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Search of human proteins with 62865639
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62865639 aurora kinase C isoform 1 [Homo sapiens]
(309 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62865639 aurora kinase C isoform 1 [Homo sapiens] 625 e-179
gi|62865641 aurora kinase C isoform 2 [Homo sapiens] 588 e-168
gi|62865643 aurora kinase C isoform 3 [Homo sapiens] 561 e-160
gi|83776600 aurora kinase B [Homo sapiens] 477 e-135
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens] 398 e-111
gi|38327570 serine/threonine protein kinase 6 [Homo sapiens] 398 e-111
gi|38327568 serine/threonine protein kinase 6 [Homo sapiens] 398 e-111
gi|38327566 serine/threonine protein kinase 6 [Homo sapiens] 398 e-111
gi|38327564 serine/threonine protein kinase 6 [Homo sapiens] 398 e-111
gi|38327562 serine/threonine protein kinase 6 [Homo sapiens] 398 e-111
gi|121114283 polo-like kinase 4 [Homo sapiens] 182 3e-46
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 178 6e-45
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 174 1e-43
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 174 1e-43
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 174 1e-43
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 174 1e-43
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 173 2e-43
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 171 6e-43
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 171 8e-43
gi|116256471 SNF1-like kinase [Homo sapiens] 171 8e-43
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 171 1e-42
gi|28557781 protein kinase C, eta [Homo sapiens] 169 4e-42
gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent ... 169 4e-42
gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform... 167 8e-42
gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo ... 167 8e-42
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 165 4e-41
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 165 4e-41
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 165 4e-41
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 165 4e-41
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 165 4e-41
>gi|62865639 aurora kinase C isoform 1 [Homo sapiens]
Length = 309
Score = 625 bits (1612), Expect = e-179
Identities = 309/309 (100%), Positives = 309/309 (100%)
Query: 1 MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA 60
MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
Sbjct: 1 MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA 60
Query: 61 RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL 120
RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
Sbjct: 61 RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL 120
Query: 121 EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV 180
EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
Sbjct: 121 EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV 180
Query: 181 KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE 240
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
Sbjct: 181 KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE 240
Query: 241 SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV 300
SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
Sbjct: 241 SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV 300
Query: 301 LPPCAQMAS 309
LPPCAQMAS
Sbjct: 301 LPPCAQMAS 309
>gi|62865641 aurora kinase C isoform 2 [Homo sapiens]
Length = 290
Score = 588 bits (1517), Expect = e-168
Identities = 289/290 (99%), Positives = 290/290 (100%)
Query: 20 LATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQI 79
+ATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQI
Sbjct: 1 MATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQI 60
Query: 80 EKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLD 139
EKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLD
Sbjct: 61 EKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLD 120
Query: 140 EQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTM 199
EQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTM
Sbjct: 121 EQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTM 180
Query: 200 CGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFP 259
CGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFP
Sbjct: 181 CGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFP 240
Query: 260 LSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS 309
LSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
Sbjct: 241 LSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS 290
>gi|62865643 aurora kinase C isoform 3 [Homo sapiens]
Length = 275
Score = 561 bits (1446), Expect = e-160
Identities = 275/275 (100%), Positives = 275/275 (100%)
Query: 35 MRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEI 94
MRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEI
Sbjct: 1 MRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEI 60
Query: 95 QAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADAL 154
QAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADAL
Sbjct: 61 QAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADAL 120
Query: 155 TYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGR 214
TYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGR
Sbjct: 121 TYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGR 180
Query: 215 TYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLL 274
TYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLL
Sbjct: 181 TYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLL 240
Query: 275 RYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS 309
RYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
Sbjct: 241 RYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS 275
>gi|83776600 aurora kinase B [Homo sapiens]
Length = 344
Score = 477 bits (1227), Expect = e-135
Identities = 233/305 (76%), Positives = 262/305 (85%), Gaps = 2/305 (0%)
Query: 3 SPRAVVQLGKA--QPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA 60
+P A+V + ++ QP + + R T+DDFEIGRPLGKGKFGNVYLA
Sbjct: 35 TPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLA 94
Query: 61 RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL 120
R K+SHFIVALKVLFKSQIEKEG+EHQLRREIEIQAHL HPNILRLYNYF+D RR+YLIL
Sbjct: 95 REKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLIL 154
Query: 121 EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV 180
EYAPRGELYKELQKS DEQRTATI+EELADAL YCH KKVIHRDIKPENLLLG +GE+
Sbjct: 155 EYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGEL 214
Query: 181 KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE 240
KIADFGWSVH PSLRRKTMCGTLDYLPPEMIEGR ++EKVDLWCIGVLCYELLVG PPFE
Sbjct: 215 KIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFE 274
Query: 241 SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV 300
SASH+ETYRRI+KVD++FP S+P+GA+DLIS+LLR+ P ERLPLAQ+ HPWV+A+SRRV
Sbjct: 275 SASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRV 334
Query: 301 LPPCA 305
LPP A
Sbjct: 335 LPPSA 339
>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 398 bits (1022), Expect = e-111
Identities = 192/282 (68%), Positives = 231/282 (81%), Gaps = 4/282 (1%)
Query: 18 EELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKS 77
EELA+ + + R+ ++DFEIGRPLGKGKFGNVYLAR K+S FI+ALKVLFK+
Sbjct: 112 EELASKQKNEESKK----RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA 167
Query: 78 QIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEK 137
Q+EK G+EHQLRRE+EIQ+HL+HPNILRLY YFHDA RVYLILEYAP G +Y+ELQK K
Sbjct: 168 QLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK 227
Query: 138 LDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRK 197
DEQRTAT I ELA+AL+YCH K+VIHRDIKPENLLLG GE+KIADFGWSVH PS RR
Sbjct: 228 FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRT 287
Query: 198 TMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVR 257
T+CGTLDYLPPEMIEGR +DEKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+
Sbjct: 288 TLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFT 347
Query: 258 FPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 299
FP + GARDLISRLL++ P +R L ++L+HPW+ A+S +
Sbjct: 348 FPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSK 389
>gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 398 bits (1022), Expect = e-111
Identities = 192/282 (68%), Positives = 231/282 (81%), Gaps = 4/282 (1%)
Query: 18 EELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKS 77
EELA+ + + R+ ++DFEIGRPLGKGKFGNVYLAR K+S FI+ALKVLFK+
Sbjct: 112 EELASKQKNEESKK----RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA 167
Query: 78 QIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEK 137
Q+EK G+EHQLRRE+EIQ+HL+HPNILRLY YFHDA RVYLILEYAP G +Y+ELQK K
Sbjct: 168 QLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK 227
Query: 138 LDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRK 197
DEQRTAT I ELA+AL+YCH K+VIHRDIKPENLLLG GE+KIADFGWSVH PS RR
Sbjct: 228 FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRT 287
Query: 198 TMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVR 257
T+CGTLDYLPPEMIEGR +DEKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+
Sbjct: 288 TLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFT 347
Query: 258 FPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 299
FP + GARDLISRLL++ P +R L ++L+HPW+ A+S +
Sbjct: 348 FPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSK 389
>gi|38327568 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 398 bits (1022), Expect = e-111
Identities = 192/282 (68%), Positives = 231/282 (81%), Gaps = 4/282 (1%)
Query: 18 EELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKS 77
EELA+ + + R+ ++DFEIGRPLGKGKFGNVYLAR K+S FI+ALKVLFK+
Sbjct: 112 EELASKQKNEESKK----RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA 167
Query: 78 QIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEK 137
Q+EK G+EHQLRRE+EIQ+HL+HPNILRLY YFHDA RVYLILEYAP G +Y+ELQK K
Sbjct: 168 QLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK 227
Query: 138 LDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRK 197
DEQRTAT I ELA+AL+YCH K+VIHRDIKPENLLLG GE+KIADFGWSVH PS RR
Sbjct: 228 FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRT 287
Query: 198 TMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVR 257
T+CGTLDYLPPEMIEGR +DEKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+
Sbjct: 288 TLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFT 347
Query: 258 FPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 299
FP + GARDLISRLL++ P +R L ++L+HPW+ A+S +
Sbjct: 348 FPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSK 389
>gi|38327566 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 398 bits (1022), Expect = e-111
Identities = 192/282 (68%), Positives = 231/282 (81%), Gaps = 4/282 (1%)
Query: 18 EELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKS 77
EELA+ + + R+ ++DFEIGRPLGKGKFGNVYLAR K+S FI+ALKVLFK+
Sbjct: 112 EELASKQKNEESKK----RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA 167
Query: 78 QIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEK 137
Q+EK G+EHQLRRE+EIQ+HL+HPNILRLY YFHDA RVYLILEYAP G +Y+ELQK K
Sbjct: 168 QLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK 227
Query: 138 LDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRK 197
DEQRTAT I ELA+AL+YCH K+VIHRDIKPENLLLG GE+KIADFGWSVH PS RR
Sbjct: 228 FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRT 287
Query: 198 TMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVR 257
T+CGTLDYLPPEMIEGR +DEKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+
Sbjct: 288 TLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFT 347
Query: 258 FPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 299
FP + GARDLISRLL++ P +R L ++L+HPW+ A+S +
Sbjct: 348 FPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSK 389
>gi|38327564 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 398 bits (1022), Expect = e-111
Identities = 192/282 (68%), Positives = 231/282 (81%), Gaps = 4/282 (1%)
Query: 18 EELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKS 77
EELA+ + + R+ ++DFEIGRPLGKGKFGNVYLAR K+S FI+ALKVLFK+
Sbjct: 112 EELASKQKNEESKK----RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA 167
Query: 78 QIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEK 137
Q+EK G+EHQLRRE+EIQ+HL+HPNILRLY YFHDA RVYLILEYAP G +Y+ELQK K
Sbjct: 168 QLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK 227
Query: 138 LDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRK 197
DEQRTAT I ELA+AL+YCH K+VIHRDIKPENLLLG GE+KIADFGWSVH PS RR
Sbjct: 228 FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRT 287
Query: 198 TMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVR 257
T+CGTLDYLPPEMIEGR +DEKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+
Sbjct: 288 TLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFT 347
Query: 258 FPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 299
FP + GARDLISRLL++ P +R L ++L+HPW+ A+S +
Sbjct: 348 FPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSK 389
>gi|38327562 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 398 bits (1022), Expect = e-111
Identities = 192/282 (68%), Positives = 231/282 (81%), Gaps = 4/282 (1%)
Query: 18 EELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKS 77
EELA+ + + R+ ++DFEIGRPLGKGKFGNVYLAR K+S FI+ALKVLFK+
Sbjct: 112 EELASKQKNEESKK----RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA 167
Query: 78 QIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEK 137
Q+EK G+EHQLRRE+EIQ+HL+HPNILRLY YFHDA RVYLILEYAP G +Y+ELQK K
Sbjct: 168 QLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK 227
Query: 138 LDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRK 197
DEQRTAT I ELA+AL+YCH K+VIHRDIKPENLLLG GE+KIADFGWSVH PS RR
Sbjct: 228 FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRT 287
Query: 198 TMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVR 257
T+CGTLDYLPPEMIEGR +DEKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+
Sbjct: 288 TLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFT 347
Query: 258 FPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 299
FP + GARDLISRLL++ P +R L ++L+HPW+ A+S +
Sbjct: 348 FPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSK 389
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 182 bits (462), Expect = 3e-46
Identities = 91/261 (34%), Positives = 150/261 (57%), Gaps = 3/261 (1%)
Query: 40 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 99
++DF++G LGKG F VY A + VA+K++ K + K G+ +++ E++I L+
Sbjct: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
Query: 100 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEK-LDEQRTATIIEELADALTYCH 158
HP+IL LYNYF D+ VYL+LE GE+ + L+ K E + ++ + Y H
Sbjct: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
Query: 159 DKKVIHRDIKPENLLLGFRGEVKIADFGWS--VHTPSLRRKTMCGTLDYLPPEMIEGRTY 216
++HRD+ NLLL +KIADFG + + P + T+CGT +Y+ PE+ +
Sbjct: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
Query: 217 DEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRY 276
+ D+W +G + Y LL+G PPF++ + T +++ D P + + A+DLI +LLR
Sbjct: 189 GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRR 248
Query: 277 QPLERLPLAQILKHPWVQAHS 297
P +RL L+ +L HP++ +S
Sbjct: 249 NPADRLSLSSVLDHPFMSRNS 269
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 178 bits (451), Expect = 6e-45
Identities = 98/272 (36%), Positives = 154/272 (56%), Gaps = 8/272 (2%)
Query: 43 FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPN 102
+EI R +GKG F V A + VA+K++ K+Q+++E L+ ++ RE++I L HP+
Sbjct: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPH 66
Query: 103 ILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKV 162
I+RLY R +YL+ EYA GE++ L ++ E+ +++ A+ +CH + +
Sbjct: 67 IIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNI 126
Query: 163 IHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD-EKV 220
+HRD+K ENLLL +KIADFG+S + TP KT CG+ Y PE+ EG+ YD KV
Sbjct: 127 VHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKV 186
Query: 221 DLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLE 280
D+W +GV+ Y L+ G PF+ ++ R+L R P M LI +L P +
Sbjct: 187 DIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNK 246
Query: 281 RLPLAQILKHPWVQ-----AHSRRVLPPCAQM 307
RL + QI KH W++ + R++ C Q+
Sbjct: 247 RLSMEQICKHKWMKLGDADPNFDRLIAECQQL 278
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 174 bits (440), Expect = 1e-43
Identities = 95/267 (35%), Positives = 151/267 (56%), Gaps = 4/267 (1%)
Query: 40 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 99
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KLFREVRIMKILN 111
Query: 100 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 159
HPNI++L+ + +YLI+EYA GE++ L ++ E+ + ++ A+ YCH
Sbjct: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 171
Query: 160 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 217
K+++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 172 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 218 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 277
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ R L
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
Query: 278 PLERLPLAQILKHPWVQA-HSRRVLPP 303
P++R L QI+K W+ A H L P
Sbjct: 292 PIKRGTLEQIMKDRWINAGHEEDELKP 318
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 174 bits (440), Expect = 1e-43
Identities = 95/267 (35%), Positives = 151/267 (56%), Gaps = 4/267 (1%)
Query: 40 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 99
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KLFREVRIMKILN 111
Query: 100 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 159
HPNI++L+ + +YLI+EYA GE++ L ++ E+ + ++ A+ YCH
Sbjct: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 171
Query: 160 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 217
K+++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 172 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 218 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 277
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ R L
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
Query: 278 PLERLPLAQILKHPWVQA-HSRRVLPP 303
P++R L QI+K W+ A H L P
Sbjct: 292 PIKRGTLEQIMKDRWINAGHEEDELKP 318
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 174 bits (440), Expect = 1e-43
Identities = 95/267 (35%), Positives = 151/267 (56%), Gaps = 4/267 (1%)
Query: 40 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 99
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KLFREVRIMKILN 111
Query: 100 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 159
HPNI++L+ + +YLI+EYA GE++ L ++ E+ + ++ A+ YCH
Sbjct: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 171
Query: 160 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 217
K+++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 172 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 218 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 277
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ R L
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
Query: 278 PLERLPLAQILKHPWVQA-HSRRVLPP 303
P++R L QI+K W+ A H L P
Sbjct: 292 PIKRGTLEQIMKDRWINAGHEEDELKP 318
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 174 bits (440), Expect = 1e-43
Identities = 95/267 (35%), Positives = 151/267 (56%), Gaps = 4/267 (1%)
Query: 40 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 99
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KLFREVRIMKILN 111
Query: 100 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 159
HPNI++L+ + +YLI+EYA GE++ L ++ E+ + ++ A+ YCH
Sbjct: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 171
Query: 160 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 217
K+++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 172 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 218 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 277
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ R L
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
Query: 278 PLERLPLAQILKHPWVQA-HSRRVLPP 303
P++R L QI+K W+ A H L P
Sbjct: 292 PIKRGTLEQIMKDRWINAGHEEDELKP 318
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 173 bits (439), Expect = 2e-43
Identities = 91/256 (35%), Positives = 143/256 (55%), Gaps = 3/256 (1%)
Query: 40 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 99
V ++ + R +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 56 VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQ-KLFREVRIMKGLN 114
Query: 100 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 159
HPNI++L+ + +YL++EYA GE++ L ++ E+ ++ A+ YCH
Sbjct: 115 HPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQ 174
Query: 160 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 217
K ++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 175 KNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDG 234
Query: 218 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 277
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M ++ R L
Sbjct: 235 PEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLN 294
Query: 278 PLERLPLAQILKHPWV 293
P +R L QI+K W+
Sbjct: 295 PAKRCTLEQIMKDKWI 310
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 171 bits (434), Expect = 6e-43
Identities = 95/266 (35%), Positives = 153/266 (57%), Gaps = 4/266 (1%)
Query: 40 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 99
++ + + +G+G FG VY R K S +VALK + K ++ L + L+REIEI L+
Sbjct: 1 MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRN-LQREIEIMRGLR 59
Query: 100 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 159
HPNI+ + + F + V ++ +YA GEL++ L+ KL E + I +L AL Y H
Sbjct: 60 HPNIVHMLDSFETDKEVVVVTDYA-EGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHS 118
Query: 160 KKVIHRDIKPENLLLGFRGEVKIADFGWS--VHTPSLRRKTMCGTLDYLPPEMIEGRTYD 217
+++HRD+KP+N+LL G +K+ DFG++ + T ++ ++ GT Y+ PE++E R YD
Sbjct: 119 HRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYD 178
Query: 218 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 277
DLW +G + YEL VG PPF + S + ILK VR+P ++ ++ + LL
Sbjct: 179 HTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTKD 238
Query: 278 PLERLPLAQILKHPWVQAHSRRVLPP 303
P +RL +L HP++ H + P
Sbjct: 239 PRQRLSWPDLLYHPFIAGHVTIITEP 264
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 171 bits (433), Expect = 8e-43
Identities = 93/267 (34%), Positives = 149/267 (55%), Gaps = 4/267 (1%)
Query: 40 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 99
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 57 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQ-KLFREVRIMKILN 115
Query: 100 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 159
HPNI++L+ + +YL++EYA GE++ L ++ E+ ++ A+ YCH
Sbjct: 116 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 175
Query: 160 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 217
K ++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 176 KYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDG 235
Query: 218 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 277
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ +LL
Sbjct: 236 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLN 295
Query: 278 PLERLPLAQILKHPWVQ-AHSRRVLPP 303
P++R L QI+K W+ H L P
Sbjct: 296 PIKRGSLEQIMKDRWMNVGHEEEELKP 322
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 171 bits (433), Expect = 8e-43
Identities = 98/294 (33%), Positives = 159/294 (54%), Gaps = 15/294 (5%)
Query: 13 AQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALK 72
A PAG+ Q Q+P L V ++I R LGKG F V LAR + + VA+K
Sbjct: 9 ADPAGQ-----GQGQQKP-------LRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIK 56
Query: 73 VLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKEL 132
++ K++++ LE ++ RE+++ L HP+I++LY +Y++ E+A GE++ L
Sbjct: 57 IIDKTRLDSSNLE-KIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYL 115
Query: 133 QKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGW-SVHT 191
+ L E ++ A+ YCHD ++HRD+K ENLLL ++K+ADFG+ + +
Sbjct: 116 TSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYK 175
Query: 192 PSLRRKTMCGTLDYLPPEMIEGRTYD-EKVDLWCIGVLCYELLVGYPPFESASHSETYRR 250
T CG+ Y PE+ EG+ Y+ ++D+W +GV+ Y L+ G PF+ + +R
Sbjct: 176 SGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQR 235
Query: 251 ILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPC 304
+L+ R P M LI R+L P R+ +AQI +H W++A P C
Sbjct: 236 VLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPAC 289
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 171 bits (432), Expect = 1e-42
Identities = 95/253 (37%), Positives = 141/253 (55%), Gaps = 3/253 (1%)
Query: 43 FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPN 102
+E+ LGKG +G V A + S +VA+K + K +I+ E +RREIEI + L HP+
Sbjct: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Query: 103 ILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKV 162
I+ +Y F + ++ +I+EYA +GELY + + +L E+ T ++ A+ YCH V
Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
Query: 163 IHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTY-DEKV 220
+HRD+K EN+LL +KIADFG S ++ +T CG+ Y PE++ GR Y +V
Sbjct: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
Query: 221 DLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLE 280
D W +GVL Y L+ G PF+ H R+I + R P + P AR LI +L P
Sbjct: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP-TQPSDARGLIRWMLMVNPDR 293
Query: 281 RLPLAQILKHPWV 293
R + I H WV
Sbjct: 294 RATIEDIANHWWV 306
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 169 bits (427), Expect = 4e-42
Identities = 99/282 (35%), Positives = 152/282 (53%), Gaps = 15/282 (5%)
Query: 37 RLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQI-EKEGLEHQLRREIEIQ 95
RL +D+FE R LGKG FG V LAR+KE+ + A+KVL K I + + +E + + +
Sbjct: 349 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILS 408
Query: 96 AHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALT 155
HP + +L+ F R++ ++E+ G+L +QKS + DE R E+ AL
Sbjct: 409 LARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALM 468
Query: 156 YCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVH--TPSLRRKTMCGTLDYLPPEMIEG 213
+ HDK +I+RD+K +N+LL G K+ADFG + T CGT DY+ PE+++
Sbjct: 469 FLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE 528
Query: 214 RTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRL 273
Y VD W +GVL YE+L G+ PFE+ + + + IL +V +P + A ++
Sbjct: 529 MLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSF 588
Query: 274 LRYQPLERL-PLAQ-----ILKHP------WVQAHSRRVLPP 303
+ P RL L Q IL+HP W Q + R++ PP
Sbjct: 589 MTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPP 630
>gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent
protein kinase-1 [Homo sapiens]
Length = 471
Score = 169 bits (427), Expect = 4e-42
Identities = 97/276 (35%), Positives = 148/276 (53%), Gaps = 6/276 (2%)
Query: 25 QTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGL 84
Q AQ P P +R +DF+ G+ LG+G F V LAR + A+K+L K I KE
Sbjct: 85 QHAQPPPQPRKKR--PEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENK 142
Query: 85 EHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTA 144
+ RE ++ + L HP ++LY F RR+Y L YA GEL K ++K DE T
Sbjct: 143 VPYVTRERDVMSRLDHPFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTR 202
Query: 145 TIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFG----WSVHTPSLRRKTMC 200
E+ AL Y H K +IHRD+KPEN+LL ++I DFG S + R +
Sbjct: 203 FYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFV 262
Query: 201 GTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPL 260
GT Y+ PE++ ++ + DLW +G + Y+L+ G PPF + + +++I+K++ FP
Sbjct: 263 GTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPE 322
Query: 261 SMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAH 296
ARDL+ +LL +RL ++ + ++AH
Sbjct: 323 KFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAH 358
>gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform 1
[Homo sapiens]
Length = 556
Score = 167 bits (424), Expect = 8e-42
Identities = 96/276 (34%), Positives = 148/276 (53%), Gaps = 6/276 (2%)
Query: 25 QTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGL 84
Q AQ P P +R +DF+ G+ LG+G F V LAR + A+K+L K I KE
Sbjct: 66 QHAQPPPQPRKKR--PEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENK 123
Query: 85 EHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTA 144
+ RE ++ + L HP ++LY F D ++Y L YA GEL K ++K DE T
Sbjct: 124 VPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTR 183
Query: 145 TIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFG----WSVHTPSLRRKTMC 200
E+ AL Y H K +IHRD+KPEN+LL ++I DFG S + R +
Sbjct: 184 FYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFV 243
Query: 201 GTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPL 260
GT Y+ PE++ ++ + DLW +G + Y+L+ G PPF + + +++I+K++ FP
Sbjct: 244 GTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPE 303
Query: 261 SMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAH 296
ARDL+ +LL +RL ++ + ++AH
Sbjct: 304 KFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAH 339
>gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo
sapiens]
Length = 396
Score = 167 bits (424), Expect = 8e-42
Identities = 96/276 (34%), Positives = 148/276 (53%), Gaps = 6/276 (2%)
Query: 25 QTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGL 84
Q AQ P P +R +DF+ G+ LG+G F V LAR + A+K+L K I KE
Sbjct: 39 QHAQPPPQPRKKR--PEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENK 96
Query: 85 EHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTA 144
+ RE ++ + L HP ++LY F D ++Y L YA GEL K ++K DE T
Sbjct: 97 VPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTR 156
Query: 145 TIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFG----WSVHTPSLRRKTMC 200
E+ AL Y H K +IHRD+KPEN+LL ++I DFG S + R +
Sbjct: 157 FYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFV 216
Query: 201 GTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPL 260
GT Y+ PE++ ++ + DLW +G + Y+L+ G PPF + + +++I+K++ FP
Sbjct: 217 GTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPE 276
Query: 261 SMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAH 296
ARDL+ +LL +RL ++ + ++AH
Sbjct: 277 KFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAH 312
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 165 bits (418), Expect = 4e-41
Identities = 89/256 (34%), Positives = 144/256 (56%), Gaps = 3/256 (1%)
Query: 40 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 99
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLN 108
Query: 100 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 159
HPNI++L+ + +YL++EYA GE++ L ++ E+ ++ A+ YCH
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168
Query: 160 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 217
K ++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 218 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 277
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ + L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
Query: 278 PLERLPLAQILKHPWV 293
P +R L QI+K W+
Sbjct: 289 PSKRGTLEQIMKDRWM 304
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 165 bits (418), Expect = 4e-41
Identities = 89/256 (34%), Positives = 144/256 (56%), Gaps = 3/256 (1%)
Query: 40 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 99
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLN 108
Query: 100 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 159
HPNI++L+ + +YL++EYA GE++ L ++ E+ ++ A+ YCH
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168
Query: 160 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 217
K ++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 218 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 277
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ + L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
Query: 278 PLERLPLAQILKHPWV 293
P +R L QI+K W+
Sbjct: 289 PSKRGTLEQIMKDRWM 304
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 165 bits (418), Expect = 4e-41
Identities = 89/256 (34%), Positives = 144/256 (56%), Gaps = 3/256 (1%)
Query: 40 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 99
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLN 108
Query: 100 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 159
HPNI++L+ + +YL++EYA GE++ L ++ E+ ++ A+ YCH
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168
Query: 160 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 217
K ++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 218 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 277
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ + L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
Query: 278 PLERLPLAQILKHPWV 293
P +R L QI+K W+
Sbjct: 289 PSKRGTLEQIMKDRWM 304
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 165 bits (418), Expect = 4e-41
Identities = 89/256 (34%), Positives = 144/256 (56%), Gaps = 3/256 (1%)
Query: 40 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 99
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLN 108
Query: 100 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 159
HPNI++L+ + +YL++EYA GE++ L ++ E+ ++ A+ YCH
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168
Query: 160 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 217
K ++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 218 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 277
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ + L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
Query: 278 PLERLPLAQILKHPWV 293
P +R L QI+K W+
Sbjct: 289 PSKRGTLEQIMKDRWM 304
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 165 bits (418), Expect = 4e-41
Identities = 89/256 (34%), Positives = 144/256 (56%), Gaps = 3/256 (1%)
Query: 40 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 99
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 17 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLN 75
Query: 100 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 159
HPNI++L+ + +YL++EYA GE++ L ++ E+ ++ A+ YCH
Sbjct: 76 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 135
Query: 160 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 217
K ++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 136 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 195
Query: 218 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 277
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ + L
Sbjct: 196 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 255
Query: 278 PLERLPLAQILKHPWV 293
P +R L QI+K W+
Sbjct: 256 PSKRGTLEQIMKDRWM 271
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,268,116
Number of Sequences: 37866
Number of extensions: 553469
Number of successful extensions: 3801
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 743
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 1191
Number of HSP's gapped (non-prelim): 1010
length of query: 309
length of database: 18,247,518
effective HSP length: 102
effective length of query: 207
effective length of database: 14,385,186
effective search space: 2977733502
effective search space used: 2977733502
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.