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Search of human proteins with 62243658
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]
(3661 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens] 7235 0.0
gi|239745503 PREDICTED: hypothetical protein XP_002343506 [Homo ... 981 0.0
gi|4826730 FK506 binding protein 12-rapamycin associated protein... 225 5e-58
gi|157266317 ataxia telangiectasia and Rad3 related protein [Hom... 186 4e-46
gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad... 186 4e-46
gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens] 173 2e-42
gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens] 173 2e-42
gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, pa... 173 2e-42
gi|13654237 protein kinase, DNA-activated, catalytic polypeptide... 122 8e-27
gi|126032350 protein kinase, DNA-activated, catalytic polypeptid... 95 1e-18
gi|113430845 PREDICTED: similar to protein kinase, DNA-activated... 95 1e-18
gi|4507691 transformation/transcription domain-associated protei... 59 1e-07
gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo sa... 58 2e-07
gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapi... 53 5e-06
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 45 0.001
gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypept... 45 0.002
gi|156104908 myosin heavy chain 6 [Homo sapiens] 45 0.002
gi|169218238 PREDICTED: similar to ataxia telangiectasia and Rad... 43 0.005
gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo... 42 0.011
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 42 0.011
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 42 0.015
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 41 0.019
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 41 0.019
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 41 0.025
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid... 40 0.033
gi|51093830 bicaudal D homolog 1 isoform 2 [Homo sapiens] 40 0.033
gi|51039802 bicaudal D homolog 1 isoform 1 [Homo sapiens] 40 0.033
gi|198442834 coiled-coil domain containing 152 [Homo sapiens] 40 0.033
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide... 40 0.042
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 40 0.042
>gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]
Length = 3661
Score = 7235 bits (18773), Expect = 0.0
Identities = 3661/3661 (100%), Positives = 3661/3661 (100%)
Query: 1 MSRRAPGSRLSSGGGGGGTKYPRSWNDWQPRTDSASADPDNLKYSSSRDRGGSSSYGLQP 60
MSRRAPGSRLSSGGGGGGTKYPRSWNDWQPRTDSASADPDNLKYSSSRDRGGSSSYGLQP
Sbjct: 1 MSRRAPGSRLSSGGGGGGTKYPRSWNDWQPRTDSASADPDNLKYSSSRDRGGSSSYGLQP 60
Query: 61 SNSAVVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRVNNVTSPEFTS 120
SNSAVVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRVNNVTSPEFTS
Sbjct: 61 SNSAVVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRVNNVTSPEFTS 120
Query: 121 VQHGSRALATKDMRKSQERSMSYSDESRLSNLLRRITREDDRDRRLATVKQLKEFIQQPE 180
VQHGSRALATKDMRKSQERSMSYSDESRLSNLLRRITREDDRDRRLATVKQLKEFIQQPE
Sbjct: 121 VQHGSRALATKDMRKSQERSMSYSDESRLSNLLRRITREDDRDRRLATVKQLKEFIQQPE 180
Query: 181 NKLVLVKQLDNILAAVHDVLNESSKLLQELRQEGACCLGLLCASLSYEAEKIFKWIFSKF 240
NKLVLVKQLDNILAAVHDVLNESSKLLQELRQEGACCLGLLCASLSYEAEKIFKWIFSKF
Sbjct: 181 NKLVLVKQLDNILAAVHDVLNESSKLLQELRQEGACCLGLLCASLSYEAEKIFKWIFSKF 240
Query: 241 SSSAKDEVKLLYLCATYKALETVGEKKAFSSVMQLVMTSLQSILENVDTPELLCKCVKCI 300
SSSAKDEVKLLYLCATYKALETVGEKKAFSSVMQLVMTSLQSILENVDTPELLCKCVKCI
Sbjct: 241 SSSAKDEVKLLYLCATYKALETVGEKKAFSSVMQLVMTSLQSILENVDTPELLCKCVKCI 300
Query: 301 LLVARCYPHIFSTNFRDTVDILVGWHIDHTQKPSLTQQVSGWLQSLEPFWVADLAFSTTL 360
LLVARCYPHIFSTNFRDTVDILVGWHIDHTQKPSLTQQVSGWLQSLEPFWVADLAFSTTL
Sbjct: 301 LLVARCYPHIFSTNFRDTVDILVGWHIDHTQKPSLTQQVSGWLQSLEPFWVADLAFSTTL 360
Query: 361 LGQFLEDMEAYAEDLSHVASGESVDEDVPPPSVSLPKLAALLRVFSTVVRSIGERFSPIR 420
LGQFLEDMEAYAEDLSHVASGESVDEDVPPPSVSLPKLAALLRVFSTVVRSIGERFSPIR
Sbjct: 361 LGQFLEDMEAYAEDLSHVASGESVDEDVPPPSVSLPKLAALLRVFSTVVRSIGERFSPIR 420
Query: 421 GPPITEAYVTDVLYRVMRCVTAANQVFFSEAVLTAANECVGVLLGSLDPSMTIHCDMVIT 480
GPPITEAYVTDVLYRVMRCVTAANQVFFSEAVLTAANECVGVLLGSLDPSMTIHCDMVIT
Sbjct: 421 GPPITEAYVTDVLYRVMRCVTAANQVFFSEAVLTAANECVGVLLGSLDPSMTIHCDMVIT 480
Query: 481 YGLDQLENCQTCGTDYIISVLNLLTLIVEQINTKLPSSFVEKLFIPSSKLLFLRYHKEKE 540
YGLDQLENCQTCGTDYIISVLNLLTLIVEQINTKLPSSFVEKLFIPSSKLLFLRYHKEKE
Sbjct: 481 YGLDQLENCQTCGTDYIISVLNLLTLIVEQINTKLPSSFVEKLFIPSSKLLFLRYHKEKE 540
Query: 541 VVAVAHAVYQAVLSLKNIPVLETAYKLILGEMTCALNNLLHSLQLPEACSEIKHEAFKNH 600
VVAVAHAVYQAVLSLKNIPVLETAYKLILGEMTCALNNLLHSLQLPEACSEIKHEAFKNH
Sbjct: 541 VVAVAHAVYQAVLSLKNIPVLETAYKLILGEMTCALNNLLHSLQLPEACSEIKHEAFKNH 600
Query: 601 VFNVDNAKFVVIFDLSALTTIGNAKNSLIGMWALSPTVFALLSKNLMIVHSDLAVHFPAI 660
VFNVDNAKFVVIFDLSALTTIGNAKNSLIGMWALSPTVFALLSKNLMIVHSDLAVHFPAI
Sbjct: 601 VFNVDNAKFVVIFDLSALTTIGNAKNSLIGMWALSPTVFALLSKNLMIVHSDLAVHFPAI 660
Query: 661 QYAVLYTLYSHCTRHDHFISSSLSSSSPSLFDGAVISTVTTATKKHFSIILNLLGILLKK 720
QYAVLYTLYSHCTRHDHFISSSLSSSSPSLFDGAVISTVTTATKKHFSIILNLLGILLKK
Sbjct: 661 QYAVLYTLYSHCTRHDHFISSSLSSSSPSLFDGAVISTVTTATKKHFSIILNLLGILLKK 720
Query: 721 DNLNQDTRKLLMTWALEAAVLMKKSETYAPLFSLPSFHKFCKGLLANTLVEDVNICLQAC 780
DNLNQDTRKLLMTWALEAAVLMKKSETYAPLFSLPSFHKFCKGLLANTLVEDVNICLQAC
Sbjct: 721 DNLNQDTRKLLMTWALEAAVLMKKSETYAPLFSLPSFHKFCKGLLANTLVEDVNICLQAC 780
Query: 781 SSLHALSSSLPDDLLQRCVDVCRVQLVHSGTRIRQAFGKLLKSIPLDVVLSNNNHTEIQE 840
SSLHALSSSLPDDLLQRCVDVCRVQLVHSGTRIRQAFGKLLKSIPLDVVLSNNNHTEIQE
Sbjct: 781 SSLHALSSSLPDDLLQRCVDVCRVQLVHSGTRIRQAFGKLLKSIPLDVVLSNNNHTEIQE 840
Query: 841 ISLALRSHMSKAPSNTFHPQDFSDVISFILYGNSHRTGKDNWLERLFYSCQRLDKRDQST 900
ISLALRSHMSKAPSNTFHPQDFSDVISFILYGNSHRTGKDNWLERLFYSCQRLDKRDQST
Sbjct: 841 ISLALRSHMSKAPSNTFHPQDFSDVISFILYGNSHRTGKDNWLERLFYSCQRLDKRDQST 900
Query: 901 IPRNLLKTDAVLWQWAIWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHTLNPDQD 960
IPRNLLKTDAVLWQWAIWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHTLNPDQD
Sbjct: 901 IPRNLLKTDAVLWQWAIWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHTLNPDQD 960
Query: 961 VSQWTTADNDEGHGNNQLRLVLLLQYLENLEKLMYNAYEGCANALTSPPKVIRTFFYTNR 1020
VSQWTTADNDEGHGNNQLRLVLLLQYLENLEKLMYNAYEGCANALTSPPKVIRTFFYTNR
Sbjct: 961 VSQWTTADNDEGHGNNQLRLVLLLQYLENLEKLMYNAYEGCANALTSPPKVIRTFFYTNR 1020
Query: 1021 QTCQDWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLTEMKTTSLSQGNELEVTIMMVVEAL 1080
QTCQDWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLTEMKTTSLSQGNELEVTIMMVVEAL
Sbjct: 1021 QTCQDWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLTEMKTTSLSQGNELEVTIMMVVEAL 1080
Query: 1081 CELHCPEAIQGIAVWSSSIVGKNLLWINSVAQQAEGRFEKASVEYQEHLCAMTGVDCCIS 1140
CELHCPEAIQGIAVWSSSIVGKNLLWINSVAQQAEGRFEKASVEYQEHLCAMTGVDCCIS
Sbjct: 1081 CELHCPEAIQGIAVWSSSIVGKNLLWINSVAQQAEGRFEKASVEYQEHLCAMTGVDCCIS 1140
Query: 1141 SFDKSVLTLANAGRNSASPKHSLNGESRKTVLSKPTDSSPEVINYLGNKACECYISIADW 1200
SFDKSVLTLANAGRNSASPKHSLNGESRKTVLSKPTDSSPEVINYLGNKACECYISIADW
Sbjct: 1141 SFDKSVLTLANAGRNSASPKHSLNGESRKTVLSKPTDSSPEVINYLGNKACECYISIADW 1200
Query: 1201 AAVQEWQNAIHDLKKSTSSTSLNLKADFNYIKSLSSFESGKFVECTEQLELLPGENINLL 1260
AAVQEWQNAIHDLKKSTSSTSLNLKADFNYIKSLSSFESGKFVECTEQLELLPGENINLL
Sbjct: 1201 AAVQEWQNAIHDLKKSTSSTSLNLKADFNYIKSLSSFESGKFVECTEQLELLPGENINLL 1260
Query: 1261 AGGSKEKIDMKKLLPNMLSPDPRELQKSIEVQLLRSSVCLATALNPIEQDQKWQSITENV 1320
AGGSKEKIDMKKLLPNMLSPDPRELQKSIEVQLLRSSVCLATALNPIEQDQKWQSITENV
Sbjct: 1261 AGGSKEKIDMKKLLPNMLSPDPRELQKSIEVQLLRSSVCLATALNPIEQDQKWQSITENV 1320
Query: 1321 VKYLKQTSRIAIGPLRLSTLTVSQSLPVLSTLQLYCSSALENTVSNRLSTEDCLIPLFSE 1380
VKYLKQTSRIAIGPLRLSTLTVSQSLPVLSTLQLYCSSALENTVSNRLSTEDCLIPLFSE
Sbjct: 1321 VKYLKQTSRIAIGPLRLSTLTVSQSLPVLSTLQLYCSSALENTVSNRLSTEDCLIPLFSE 1380
Query: 1381 ALRSCKQHDVRPWMQALRYTMYQNQLLEKIKEQTVPIRSHLMELGLTAAKFARKRGNVSL 1440
ALRSCKQHDVRPWMQALRYTMYQNQLLEKIKEQTVPIRSHLMELGLTAAKFARKRGNVSL
Sbjct: 1381 ALRSCKQHDVRPWMQALRYTMYQNQLLEKIKEQTVPIRSHLMELGLTAAKFARKRGNVSL 1440
Query: 1441 ATRLLAQCSEVQLGKTTTAQDLVQHFKKLSTQGQVDEKWGPELDIEKTKLLYTAGQSTHA 1500
ATRLLAQCSEVQLGKTTTAQDLVQHFKKLSTQGQVDEKWGPELDIEKTKLLYTAGQSTHA
Sbjct: 1441 ATRLLAQCSEVQLGKTTTAQDLVQHFKKLSTQGQVDEKWGPELDIEKTKLLYTAGQSTHA 1500
Query: 1501 MEMLSSCAISFCKSVKAEYAVAKSILTLAKWIQAEWKEISGQLKQVYRAQHQQNFTGLST 1560
MEMLSSCAISFCKSVKAEYAVAKSILTLAKWIQAEWKEISGQLKQVYRAQHQQNFTGLST
Sbjct: 1501 MEMLSSCAISFCKSVKAEYAVAKSILTLAKWIQAEWKEISGQLKQVYRAQHQQNFTGLST 1560
Query: 1561 LSKNILTLIELPSVNTMEEEYPRIESESTVHIGVGEPDFILGQLYHLSSVQAPEVAKSWA 1620
LSKNILTLIELPSVNTMEEEYPRIESESTVHIGVGEPDFILGQLYHLSSVQAPEVAKSWA
Sbjct: 1561 LSKNILTLIELPSVNTMEEEYPRIESESTVHIGVGEPDFILGQLYHLSSVQAPEVAKSWA 1620
Query: 1621 ALASWAYRWGRKVVDNASQGEGVRLLPREKSEVQNLLPDTITEEEKERIYGILGQAVCRP 1680
ALASWAYRWGRKVVDNASQGEGVRLLPREKSEVQNLLPDTITEEEKERIYGILGQAVCRP
Sbjct: 1621 ALASWAYRWGRKVVDNASQGEGVRLLPREKSEVQNLLPDTITEEEKERIYGILGQAVCRP 1680
Query: 1681 AGIQDEDITLQITESEDNEEDDMVDVIWRQLISSCPWLSELDESATEGVIKVWRKVVDRI 1740
AGIQDEDITLQITESEDNEEDDMVDVIWRQLISSCPWLSELDESATEGVIKVWRKVVDRI
Sbjct: 1681 AGIQDEDITLQITESEDNEEDDMVDVIWRQLISSCPWLSELDESATEGVIKVWRKVVDRI 1740
Query: 1741 FSLYKLSCSAYFTFLKLNAGQIPLDEDDPRLHLSHRVEQSTDDMIVMATLRLLRLLVKHA 1800
FSLYKLSCSAYFTFLKLNAGQIPLDEDDPRLHLSHRVEQSTDDMIVMATLRLLRLLVKHA
Sbjct: 1741 FSLYKLSCSAYFTFLKLNAGQIPLDEDDPRLHLSHRVEQSTDDMIVMATLRLLRLLVKHA 1800
Query: 1801 GELRQYLEHGLETTPTAPWRGIIPQLFSRLNHPEVYVRQSICNLLCRVAQDSPHLILYPA 1860
GELRQYLEHGLETTPTAPWRGIIPQLFSRLNHPEVYVRQSICNLLCRVAQDSPHLILYPA
Sbjct: 1801 GELRQYLEHGLETTPTAPWRGIIPQLFSRLNHPEVYVRQSICNLLCRVAQDSPHLILYPA 1860
Query: 1861 IVGTISLSSESQASGNKFSTAIPTLLGNIQGEELLVSECEGGSPPASQDSNKDEPKSGLN 1920
IVGTISLSSESQASGNKFSTAIPTLLGNIQGEELLVSECEGGSPPASQDSNKDEPKSGLN
Sbjct: 1861 IVGTISLSSESQASGNKFSTAIPTLLGNIQGEELLVSECEGGSPPASQDSNKDEPKSGLN 1920
Query: 1921 EDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVAELRRVTVLWDELWLGVLLQQHMYVLRR 1980
EDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVAELRRVTVLWDELWLGVLLQQHMYVLRR
Sbjct: 1921 EDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVAELRRVTVLWDELWLGVLLQQHMYVLRR 1980
Query: 1981 IQQLEDEVKRVQNNNTLRKEEKIAIMREKHTALMKPIVFALEHVRSITAAPAETPHEKWF 2040
IQQLEDEVKRVQNNNTLRKEEKIAIMREKHTALMKPIVFALEHVRSITAAPAETPHEKWF
Sbjct: 1981 IQQLEDEVKRVQNNNTLRKEEKIAIMREKHTALMKPIVFALEHVRSITAAPAETPHEKWF 2040
Query: 2041 QDNYGDAIENALEKLKTPLNPAKPGSSWIPFKEIMLSLQQRAQKRASYILRLEEISPWLA 2100
QDNYGDAIENALEKLKTPLNPAKPGSSWIPFKEIMLSLQQRAQKRASYILRLEEISPWLA
Sbjct: 2041 QDNYGDAIENALEKLKTPLNPAKPGSSWIPFKEIMLSLQQRAQKRASYILRLEEISPWLA 2100
Query: 2101 AMTNTEIALPGEVSARDTVTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDL 2160
AMTNTEIALPGEVSARDTVTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDL
Sbjct: 2101 AMTNTEIALPGEVSARDTVTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDL 2160
Query: 2161 HLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKR 2220
HLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKR
Sbjct: 2161 HLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKR 2220
Query: 2221 WQQREAALQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVM 2280
WQQREAALQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVM
Sbjct: 2221 WQQREAALQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVM 2280
Query: 2281 KAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDN 2340
KAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDN
Sbjct: 2281 KAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDN 2340
Query: 2341 VLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVL 2400
VLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVL
Sbjct: 2341 VLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVL 2400
Query: 2401 HIMRRGRETLLTLLEAFVYDPLVDWTAGGEAGFAGAVYGGGGQQAESKQSKREMEREITR 2460
HIMRRGRETLLTLLEAFVYDPLVDWTAGGEAGFAGAVYGGGGQQAESKQSKREMEREITR
Sbjct: 2401 HIMRRGRETLLTLLEAFVYDPLVDWTAGGEAGFAGAVYGGGGQQAESKQSKREMEREITR 2460
Query: 2461 SLFSSRVAEIKVNWFKNRDEMLVVLPKLDGSLDEYLSLQEQLTDVEKLQGKLLEEIEFLE 2520
SLFSSRVAEIKVNWFKNRDEMLVVLPKLDGSLDEYLSLQEQLTDVEKLQGKLLEEIEFLE
Sbjct: 2461 SLFSSRVAEIKVNWFKNRDEMLVVLPKLDGSLDEYLSLQEQLTDVEKLQGKLLEEIEFLE 2520
Query: 2521 GAEGVDHPSHTLQHRYSEHTQLQTQQRAVQEAIQVKLNEFEQWITHYQAAFNNLEATQLA 2580
GAEGVDHPSHTLQHRYSEHTQLQTQQRAVQEAIQVKLNEFEQWITHYQAAFNNLEATQLA
Sbjct: 2521 GAEGVDHPSHTLQHRYSEHTQLQTQQRAVQEAIQVKLNEFEQWITHYQAAFNNLEATQLA 2580
Query: 2581 SLLQEISTQMDLGPPSYVPATAFLQNAGQAHLISQCEQLEGEVGALLQQRRSVLRGCLEQ 2640
SLLQEISTQMDLGPPSYVPATAFLQNAGQAHLISQCEQLEGEVGALLQQRRSVLRGCLEQ
Sbjct: 2581 SLLQEISTQMDLGPPSYVPATAFLQNAGQAHLISQCEQLEGEVGALLQQRRSVLRGCLEQ 2640
Query: 2641 LHHYATVALQYPKAIFQKHRIEQWKTWMEELICNTTVERCQELYRKYEMQYAPQPPPTVC 2700
LHHYATVALQYPKAIFQKHRIEQWKTWMEELICNTTVERCQELYRKYEMQYAPQPPPTVC
Sbjct: 2641 LHHYATVALQYPKAIFQKHRIEQWKTWMEELICNTTVERCQELYRKYEMQYAPQPPPTVC 2700
Query: 2701 QFITATEMTLQRYAADINSRLIRQVERLKQEAVTVPVCEDQLKEIERCIKVFLHENGEEG 2760
QFITATEMTLQRYAADINSRLIRQVERLKQEAVTVPVCEDQLKEIERCIKVFLHENGEEG
Sbjct: 2701 QFITATEMTLQRYAADINSRLIRQVERLKQEAVTVPVCEDQLKEIERCIKVFLHENGEEG 2760
Query: 2761 SLSLASVIISALCTLTRRNLMMEGAASSAGEQLVDLTSRDGAWFLEELCSMSGNVTCLVQ 2820
SLSLASVIISALCTLTRRNLMMEGAASSAGEQLVDLTSRDGAWFLEELCSMSGNVTCLVQ
Sbjct: 2761 SLSLASVIISALCTLTRRNLMMEGAASSAGEQLVDLTSRDGAWFLEELCSMSGNVTCLVQ 2820
Query: 2821 LLKQCHLVPQDLDIPNPMEASETVHLANGVYTSLQELNSNFRQIIFPEALRCLMKGEYTL 2880
LLKQCHLVPQDLDIPNPMEASETVHLANGVYTSLQELNSNFRQIIFPEALRCLMKGEYTL
Sbjct: 2821 LLKQCHLVPQDLDIPNPMEASETVHLANGVYTSLQELNSNFRQIIFPEALRCLMKGEYTL 2880
Query: 2881 ESMLHELDGLIEQTTDGVPLQTLVESLQAYLRNAAMGLEEETHAHYIDVARLLHAQYGEL 2940
ESMLHELDGLIEQTTDGVPLQTLVESLQAYLRNAAMGLEEETHAHYIDVARLLHAQYGEL
Sbjct: 2881 ESMLHELDGLIEQTTDGVPLQTLVESLQAYLRNAAMGLEEETHAHYIDVARLLHAQYGEL 2940
Query: 2941 IQPRNGSVDETPKMSAGQMLLVAFDGMFAQVETAFSLLVEKLNKMEIPIAWRKIDIIREA 3000
IQPRNGSVDETPKMSAGQMLLVAFDGMFAQVETAFSLLVEKLNKMEIPIAWRKIDIIREA
Sbjct: 2941 IQPRNGSVDETPKMSAGQMLLVAFDGMFAQVETAFSLLVEKLNKMEIPIAWRKIDIIREA 3000
Query: 3001 RSTQVNFFDDDNHRQVLEEIFFLKRLQTIKEFFRLCGTFSKTLSGSSSLEDQNTVNGPVQ 3060
RSTQVNFFDDDNHRQVLEEIFFLKRLQTIKEFFRLCGTFSKTLSGSSSLEDQNTVNGPVQ
Sbjct: 3001 RSTQVNFFDDDNHRQVLEEIFFLKRLQTIKEFFRLCGTFSKTLSGSSSLEDQNTVNGPVQ 3060
Query: 3061 IVNVKTLFRNSCFSEDQMAKPIKAFTADFVRQLLIGLPNQALGLTLCSFISALGVDIIAQ 3120
IVNVKTLFRNSCFSEDQMAKPIKAFTADFVRQLLIGLPNQALGLTLCSFISALGVDIIAQ
Sbjct: 3061 IVNVKTLFRNSCFSEDQMAKPIKAFTADFVRQLLIGLPNQALGLTLCSFISALGVDIIAQ 3120
Query: 3121 VEAKDFGAESKVSVDDLCKKAVEHNIQIGKFSQLVMNRATVLASSYDTAWKKHDLVRRLE 3180
VEAKDFGAESKVSVDDLCKKAVEHNIQIGKFSQLVMNRATVLASSYDTAWKKHDLVRRLE
Sbjct: 3121 VEAKDFGAESKVSVDDLCKKAVEHNIQIGKFSQLVMNRATVLASSYDTAWKKHDLVRRLE 3180
Query: 3181 TSISSCKTSLQRVQLHIAMFQWQHEDLLINRPQAMSVTPPPRSAILTSMKKKLHTLSQIE 3240
TSISSCKTSLQRVQLHIAMFQWQHEDLLINRPQAMSVTPPPRSAILTSMKKKLHTLSQIE
Sbjct: 3181 TSISSCKTSLQRVQLHIAMFQWQHEDLLINRPQAMSVTPPPRSAILTSMKKKLHTLSQIE 3240
Query: 3241 TSIATVQEKLAALESSIEQRLKWAGGANPALAPVLQDFEATIAERRNLVLKESQRASQVT 3300
TSIATVQEKLAALESSIEQRLKWAGGANPALAPVLQDFEATIAERRNLVLKESQRASQVT
Sbjct: 3241 TSIATVQEKLAALESSIEQRLKWAGGANPALAPVLQDFEATIAERRNLVLKESQRASQVT 3300
Query: 3301 FLCSNIIHFESLRTRTAEALNLDAALFELIKRCQQMCSFASQFNSSVSELELRLLQRVDT 3360
FLCSNIIHFESLRTRTAEALNLDAALFELIKRCQQMCSFASQFNSSVSELELRLLQRVDT
Sbjct: 3301 FLCSNIIHFESLRTRTAEALNLDAALFELIKRCQQMCSFASQFNSSVSELELRLLQRVDT 3360
Query: 3361 GLEHPIGSSEWLLSAHKQLTQDMSTQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNR 3420
GLEHPIGSSEWLLSAHKQLTQDMSTQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNR
Sbjct: 3361 GLEHPIGSSEWLLSAHKQLTQDMSTQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNR 3420
Query: 3421 QLGDVKHLLKAMAKDEEAALADGEDVPYENSVRQFLGEYKSWQDNIQTVLFTLVQAMGQV 3480
QLGDVKHLLKAMAKDEEAALADGEDVPYENSVRQFLGEYKSWQDNIQTVLFTLVQAMGQV
Sbjct: 3421 QLGDVKHLLKAMAKDEEAALADGEDVPYENSVRQFLGEYKSWQDNIQTVLFTLVQAMGQV 3480
Query: 3481 RSQEHVEMLQEITPTLKELKTQSQSIYNNLVSFASPLVTDATNECSSPTSSATYQPSFAA 3540
RSQEHVEMLQEITPTLKELKTQSQSIYNNLVSFASPLVTDATNECSSPTSSATYQPSFAA
Sbjct: 3481 RSQEHVEMLQEITPTLKELKTQSQSIYNNLVSFASPLVTDATNECSSPTSSATYQPSFAA 3540
Query: 3541 AVRSNTGQKTQPDVMSQNARKLIQKNLATSADTPPSTVPGTGKSVACSPKKAVRDPKTGK 3600
AVRSNTGQKTQPDVMSQNARKLIQKNLATSADTPPSTVPGTGKSVACSPKKAVRDPKTGK
Sbjct: 3541 AVRSNTGQKTQPDVMSQNARKLIQKNLATSADTPPSTVPGTGKSVACSPKKAVRDPKTGK 3600
Query: 3601 AVQERNSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLAQLYEGWTAW 3660
AVQERNSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLAQLYEGWTAW
Sbjct: 3601 AVQERNSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLAQLYEGWTAW 3660
Query: 3661 V 3661
V
Sbjct: 3661 V 3661
>gi|239745503 PREDICTED: hypothetical protein XP_002343506 [Homo
sapiens]
Length = 501
Score = 981 bits (2537), Expect = 0.0
Identities = 487/501 (97%), Positives = 490/501 (97%)
Query: 732 MTWALEAAVLMKKSETYAPLFSLPSFHKFCKGLLANTLVEDVNICLQACSSLHALSSSLP 791
MTWALE AVLMKKSETYAPLF LPSFHKFCKGLLANTLVEDVNICLQACSSL ALSSSLP
Sbjct: 1 MTWALEVAVLMKKSETYAPLFCLPSFHKFCKGLLANTLVEDVNICLQACSSLPALSSSLP 60
Query: 792 DDLLQRCVDVCRVQLVHSGTRIRQAFGKLLKSIPLDVVLSNNNHTEIQEISLALRSHMSK 851
DDLLQRCVDVCRVQLVH GTRIRQAFGKLLKSIPLDV+LSNNNHTEIQEISLALRSHMSK
Sbjct: 61 DDLLQRCVDVCRVQLVHCGTRIRQAFGKLLKSIPLDVILSNNNHTEIQEISLALRSHMSK 120
Query: 852 APSNTFHPQDFSDVISFILYGNSHRTGKDNWLERLFYSCQRLDKRDQSTIPRNLLKTDAV 911
APSNTFHPQDFSDVISFILYGNSHRTGKDNWLERLFYSCQRLDK DQSTIPRNLLKTDA+
Sbjct: 121 APSNTFHPQDFSDVISFILYGNSHRTGKDNWLERLFYSCQRLDKHDQSTIPRNLLKTDAI 180
Query: 912 LWQWAIWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHTLNPDQDVSQWTTADNDE 971
LWQWAIWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHTLNPDQDVSQWTTAD+DE
Sbjct: 181 LWQWAIWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHTLNPDQDVSQWTTADSDE 240
Query: 972 GHGNNQLRLVLLLQYLENLEKLMYNAYEGCANALTSPPKVIRTFFYTNRQTCQDWLTRIR 1031
GHGNNQLRLVLLLQYLE LEKLMYNAYEGCANALTSPPKVIRTFFYTN QTCQDWLTRIR
Sbjct: 241 GHGNNQLRLVLLLQYLEYLEKLMYNAYEGCANALTSPPKVIRTFFYTNHQTCQDWLTRIR 300
Query: 1032 LSIMRVGLLAGQPAVTVRHGFDLLTEMKTTSLSQGNELEVTIMMVVEALCELHCPEAIQG 1091
LSIMRVGLLAGQPAVTVRHGFDLLTEMKTTSLSQGNELEVTIMMVVEALCELHCPEAIQG
Sbjct: 301 LSIMRVGLLAGQPAVTVRHGFDLLTEMKTTSLSQGNELEVTIMMVVEALCELHCPEAIQG 360
Query: 1092 IAVWSSSIVGKNLLWINSVAQQAEGRFEKASVEYQEHLCAMTGVDCCISSFDKSVLTLAN 1151
IAVWSSSIVGKNLLWINSVAQQAEGRFEKASVEYQEHLCAM GV CCISSFDKSVLTLAN
Sbjct: 361 IAVWSSSIVGKNLLWINSVAQQAEGRFEKASVEYQEHLCAMIGVHCCISSFDKSVLTLAN 420
Query: 1152 AGRNSASPKHSLNGESRKTVLSKPTDSSPEVINYLGNKACECYISIADWAAVQEWQNAIH 1211
AG NSASPKH LNGESRKTVLSKPTDSSPEVINYLGNKACECYISIADWAAVQEWQNAIH
Sbjct: 421 AGCNSASPKHCLNGESRKTVLSKPTDSSPEVINYLGNKACECYISIADWAAVQEWQNAIH 480
Query: 1212 DLKKSTSSTSLNLKADFNYIK 1232
DLKKSTSSTSLNLKADFNYIK
Sbjct: 481 DLKKSTSSTSLNLKADFNYIK 501
>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
[Homo sapiens]
Length = 2549
Score = 225 bits (574), Expect = 5e-58
Identities = 169/644 (26%), Positives = 285/644 (44%), Gaps = 124/644 (19%)
Query: 1789 TLRLLRLLVK--HAGELRQYLEHGLETTPTAPWRGIIPQLFSRLNHPEVYVRQSICNLLC 1846
TLR+L L H ++ + L G++ W +IPQL +R++ P V + I LL
Sbjct: 1903 TLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLT 1962
Query: 1847 RVAQDSPHLILYPAIVGTISLSSESQASGNKFSTAIPTLLGNIQGEELLVSECEGGSPPA 1906
+ + P ++YP ++++S+S +
Sbjct: 1963 DIGRYHPQALIYP-----LTVASKSTTTAR------------------------------ 1987
Query: 1907 SQDSNKDEPKSGLNEDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVAELRRVTVLWDELW 1966
+ +KI+ + + T+V Q M+ EL RV +LW E+W
Sbjct: 1988 --------------------HNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMW 2027
Query: 1967 LGVLLQQHMYVLRRIQQLEDEVKRVQNNNTLRKEEKIAIMREKHTALMKPIVFALEHVRS 2026
L +E R+ E + M E LE + +
Sbjct: 2028 HEGL---------------EEASRLYFG-----ERNVKGMFE-----------VLEPLHA 2056
Query: 2027 ITAAPAETPHEKWFQDNYGDAIENALE---KLKTPLNPAKPGSSWIPFKEIMLSLQQRAQ 2083
+ +T E F YG + A E K N +W + + + ++
Sbjct: 2057 MMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLP 2116
Query: 2084 KRASYILRLEEISPWLAAMTNTEIALPGEVSARDTVT-IHSVGGTITILPTKTKPKKLLF 2142
+ S L L+ +SP L + E+A+PG + I S+ ++ ++ +K +P+KL
Sbjct: 2117 QLTS--LELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTL 2174
Query: 2143 LGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRS 2202
+GS+G + +L KG EDL DER+MQ +VNT+ A + Y+V PL T S
Sbjct: 2175 MGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNS 2234
Query: 2203 GLIQWVDGATPLFGLYKRWQQREAALQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALK 2262
GLI WV L L + +++++ I+ ++ P
Sbjct: 2235 GLIGWVPHCDTLHALIRDYREKKK------------------ILLNIEHRIMLRMAPDYD 2276
Query: 2263 TVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTA 2322
+ L V V E + T + LAK LW + + W+ +Y RS A
Sbjct: 2277 HLTLMQKVE-----------VFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLA 2325
Query: 2323 VMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSL-RVPEKVPFRMTQNIET 2381
VMSMVGYI+GLGDRH N+++D +G+++HID+ CFE + + PEK+PFR+T+ +
Sbjct: 2326 VMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTN 2385
Query: 2382 ALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDW 2425
A+ VTG++G +R++C V+ ++R +++++ +LEAFVYDPL++W
Sbjct: 2386 AMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNW 2429
Score = 47.0 bits (110), Expect = 3e-04
Identities = 22/52 (42%), Positives = 32/52 (61%)
Query: 3606 NSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLAQLYEGW 3657
N A+ + RV+ KL GRD + + V QV+ +IK+AT+ +NL Q Y GW
Sbjct: 2494 NKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGW 2545
>gi|157266317 ataxia telangiectasia and Rad3 related protein [Homo
sapiens]
Length = 2644
Score = 186 bits (472), Expect = 4e-46
Identities = 105/301 (34%), Positives = 152/301 (50%), Gaps = 36/301 (11%)
Query: 2128 ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPR 2187
+ IL + KPKK+ GSDGK Y + K +DL D R+M+F S++N
Sbjct: 2300 VEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRE 2359
Query: 2188 FHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAQDSYQTPQNPGIVP 2247
H R Y+V PL G+I+WV+ L + + + + K P++ +
Sbjct: 2360 LHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSE 2419
Query: 2248 RPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTP 2307
+ +K E L+ PP W T P
Sbjct: 2420 K-------------------------------LKVFREFLLPRHPPIF---HEWFLRTFP 2445
Query: 2308 D--EWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSL 2365
D W+ +Y RSTAVMSMVGYI+GLGDRH +N+L D TGE VH+D+N F KG++
Sbjct: 2446 DPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETF 2505
Query: 2366 RVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDW 2425
VPE VPFR+T N+ +G G EG+FR +CE + +MR RE L+++L+ F++DPLV+W
Sbjct: 2506 EVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEW 2565
Query: 2426 T 2426
+
Sbjct: 2566 S 2566
Score = 38.9 bits (89), Expect = 0.095
Identities = 19/66 (28%), Positives = 41/66 (62%), Gaps = 1/66 (1%)
Query: 3597 KTGKAVQER-NSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLAQLYE 3655
+TG+ V E+ ++ + + +R++ ++ R+ +S+ V Y+I+EAT+ + L Q+Y
Sbjct: 2579 ETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYL 2638
Query: 3656 GWTAWV 3661
GWT ++
Sbjct: 2639 GWTPYM 2644
>gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad3
related protein, partial [Homo sapiens]
Length = 386
Score = 186 bits (472), Expect = 4e-46
Identities = 105/301 (34%), Positives = 152/301 (50%), Gaps = 36/301 (11%)
Query: 2128 ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPR 2187
+ IL + KPKK+ GSDGK Y + K +DL D R+M+F S++N
Sbjct: 42 VEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRE 101
Query: 2188 FHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAQDSYQTPQNPGIVP 2247
H R Y+V PL G+I+WV+ L + + + + K P++ +
Sbjct: 102 LHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSE 161
Query: 2248 RPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTP 2307
+ +K E L+ PP W T P
Sbjct: 162 K-------------------------------LKVFREFLLPRHPPIF---HEWFLRTFP 187
Query: 2308 D--EWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSL 2365
D W+ +Y RSTAVMSMVGYI+GLGDRH +N+L D TGE VH+D+N F KG++
Sbjct: 188 DPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETF 247
Query: 2366 RVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDW 2425
VPE VPFR+T N+ +G G EG+FR +CE + +MR RE L+++L+ F++DPLV+W
Sbjct: 248 EVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEW 307
Query: 2426 T 2426
+
Sbjct: 308 S 308
Score = 38.9 bits (89), Expect = 0.095
Identities = 19/66 (28%), Positives = 41/66 (62%), Gaps = 1/66 (1%)
Query: 3597 KTGKAVQER-NSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLAQLYE 3655
+TG+ V E+ ++ + + +R++ ++ R+ +S+ V Y+I+EAT+ + L Q+Y
Sbjct: 321 ETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYL 380
Query: 3656 GWTAWV 3661
GWT ++
Sbjct: 381 GWTPYM 386
>gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens]
Length = 1708
Score = 173 bits (439), Expect = 2e-42
Identities = 109/317 (34%), Positives = 157/317 (49%), Gaps = 45/317 (14%)
Query: 2119 VTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFA 2178
VTI S + PK + +GSDGK L KG +DL D + Q + NT+
Sbjct: 1333 VTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQ 1392
Query: 2179 TINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLF--------GLYKRWQQRE-AALQ 2229
+ Y V PL RSG+++W G P+ G +KR++ + +A Q
Sbjct: 1393 RNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQ 1452
Query: 2230 AQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELME 2289
QK Q + E Y + +DV + P+ +E+ ++
Sbjct: 1453 CQKKMMEVQK--------KSFEEKYE----------VFMDVCQNFQPVF-RYFCMEKFLD 1493
Query: 2290 ATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGE 2349
P W+ +Y RS A S+VGYI+GLGDRH+ N+LI+ + E
Sbjct: 1494 -----------------PAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAE 1536
Query: 2350 VVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRET 2409
+VHID V FE+GK L PE VPFR+T++I +G+TGVEGVFR CE+ + +MR +ET
Sbjct: 1537 LVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQET 1596
Query: 2410 LLTLLEAFVYDPLVDWT 2426
LLT++E +YDPL DWT
Sbjct: 1597 LLTIVEVLLYDPLFDWT 1613
Score = 42.0 bits (97), Expect = 0.011
Identities = 23/59 (38%), Positives = 36/59 (61%), Gaps = 2/59 (3%)
Query: 3603 QERNSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLAQLYEGWTAWV 3661
Q N A V R++ KL+G V+ +SV QV+ +I++A + NL++L+ GW AWV
Sbjct: 1652 QSFNKVAERVLMRLQEKLKG--VEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 1708
>gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens]
Length = 3056
Score = 173 bits (439), Expect = 2e-42
Identities = 109/317 (34%), Positives = 157/317 (49%), Gaps = 45/317 (14%)
Query: 2119 VTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFA 2178
VTI S + PK + +GSDGK L KG +DL D + Q + NT+
Sbjct: 2681 VTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQ 2740
Query: 2179 TINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLF--------GLYKRWQQRE-AALQ 2229
+ Y V PL RSG+++W G P+ G +KR++ + +A Q
Sbjct: 2741 RNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQ 2800
Query: 2230 AQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELME 2289
QK Q + E Y + +DV + P+ +E+ ++
Sbjct: 2801 CQKKMMEVQK--------KSFEEKYE----------VFMDVCQNFQPVF-RYFCMEKFLD 2841
Query: 2290 ATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGE 2349
P W+ +Y RS A S+VGYI+GLGDRH+ N+LI+ + E
Sbjct: 2842 -----------------PAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAE 2884
Query: 2350 VVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRET 2409
+VHID V FE+GK L PE VPFR+T++I +G+TGVEGVFR CE+ + +MR +ET
Sbjct: 2885 LVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQET 2944
Query: 2410 LLTLLEAFVYDPLVDWT 2426
LLT++E +YDPL DWT
Sbjct: 2945 LLTIVEVLLYDPLFDWT 2961
Score = 42.0 bits (97), Expect = 0.011
Identities = 23/59 (38%), Positives = 36/59 (61%), Gaps = 2/59 (3%)
Query: 3603 QERNSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLAQLYEGWTAWV 3661
Q N A V R++ KL+G V+ +SV QV+ +I++A + NL++L+ GW AWV
Sbjct: 3000 QSFNKVAERVLMRLQEKLKG--VEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 3056
>gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, partial
[Homo sapiens]
Length = 2934
Score = 173 bits (439), Expect = 2e-42
Identities = 109/317 (34%), Positives = 157/317 (49%), Gaps = 45/317 (14%)
Query: 2119 VTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFA 2178
VTI S + PK + +GSDGK L KG +DL D + Q + NT+
Sbjct: 2559 VTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQ 2618
Query: 2179 TINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLF--------GLYKRWQQRE-AALQ 2229
+ Y V PL RSG+++W G P+ G +KR++ + +A Q
Sbjct: 2619 RNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQ 2678
Query: 2230 AQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELME 2289
QK Q + E Y + +DV + P+ +E+ ++
Sbjct: 2679 CQKKMMEVQK--------KSFEEKYE----------VFMDVCQNFQPVF-RYFCMEKFLD 2719
Query: 2290 ATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGE 2349
P W+ +Y RS A S+VGYI+GLGDRH+ N+LI+ + E
Sbjct: 2720 -----------------PAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAE 2762
Query: 2350 VVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRET 2409
+VHID V FE+GK L PE VPFR+T++I +G+TGVEGVFR CE+ + +MR +ET
Sbjct: 2763 LVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQET 2822
Query: 2410 LLTLLEAFVYDPLVDWT 2426
LLT++E +YDPL DWT
Sbjct: 2823 LLTIVEVLLYDPLFDWT 2839
Score = 40.0 bits (92), Expect = 0.042
Identities = 22/59 (37%), Positives = 36/59 (61%), Gaps = 2/59 (3%)
Query: 3603 QERNSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLAQLYEGWTAWV 3661
Q + A V R++ KL+G V+ +SV QV+ +I++A + NL++L+ GW AWV
Sbjct: 2878 QSFDKVAERVLMRLQEKLKG--VEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 2934
>gi|13654237 protein kinase, DNA-activated, catalytic polypeptide
isoform 1 [Homo sapiens]
Length = 4128
Score = 122 bits (305), Expect = 8e-27
Identities = 89/366 (24%), Positives = 162/366 (44%), Gaps = 22/366 (6%)
Query: 2071 FKEIMLSLQQRAQKRASYILRLEEISPWLA----AMTNTEIALPGEVSARDT------VT 2120
F +I L + K + L+E SPW++ E+ +PG+ R V
Sbjct: 3659 FNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVR 3718
Query: 2121 IHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATI 2180
I +T++ + +PK+++ G D + +P+L KG EDL D+R+ Q ++N + A
Sbjct: 3719 IAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQD 3778
Query: 2181 NRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAQDSYQTP 2240
+ R YSV P+ +R GLI+W++ L ++ L ++
Sbjct: 3779 SACSQRALQLRTYSVVPMTSRLGLIEWLENTVTL---------KDLLLNTMSQEEKAAYL 3829
Query: 2241 QNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKEL 2300
+P P + + +K+ VG + + + + + + P +LL +
Sbjct: 3830 SDPRAPPCEYKDWLTKMS-GKHDVGAYMLMYKGANRTETVTS-FRKRESKVPADLLKRAF 3887
Query: 2301 WSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFE 2360
T+P+ + + +A S A++ + +I+G+GDRHL+N ++ M TG V+ ID+ F
Sbjct: 3888 VRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFG 3947
Query: 2361 KG-KSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVY 2419
+ L VPE +PFR+T+ + G+ L R L ++ FV
Sbjct: 3948 SATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVK 4007
Query: 2420 DPLVDW 2425
+P DW
Sbjct: 4008 EPSFDW 4013
>gi|126032350 protein kinase, DNA-activated, catalytic polypeptide
isoform 2 [Homo sapiens]
Length = 4097
Score = 95.1 bits (235), Expect = 1e-18
Identities = 88/378 (23%), Positives = 150/378 (39%), Gaps = 77/378 (20%)
Query: 2071 FKEIMLSLQQRAQKRASYILRLEEISPWLA----AMTNTEIALPGEVSARDT------VT 2120
F +I L + K + L+E SPW++ E+ +PG+ R V
Sbjct: 3659 FNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVR 3718
Query: 2121 IHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATI 2180
I +T++ + +PK+++ G D + +P+L KG EDL D+R+ Q ++N + A
Sbjct: 3719 IAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQD 3778
Query: 2181 NRQETPRFHARHYSVTPLGT---RSGLIQWVDGATPLFG---------LYKRWQQREAAL 2228
+ R YSV P+ + R+ ++ D T + G +YK + E
Sbjct: 3779 SACSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVT 3838
Query: 2229 QAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELM 2288
+K + SK+ P ++K M
Sbjct: 3839 SFRKRE--------------------SKV------------------PADLLKRAFVR-M 3859
Query: 2289 EATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTG 2348
+P LA + +A S A++ + +I+G+GDRHL+N ++ M TG
Sbjct: 3860 STSPEAFLA---------------LRSHFASSHALICISHWILGIGDRHLNNFMVAMETG 3904
Query: 2349 EVVHIDYNVCFEKG-KSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGR 2407
V+ ID+ F + L VPE +PFR+T+ + G+ L R
Sbjct: 3905 GVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDP 3964
Query: 2408 ETLLTLLEAFVYDPLVDW 2425
L ++ FV +P DW
Sbjct: 3965 GLLTNTMDVFVKEPSFDW 3982
>gi|113430845 PREDICTED: similar to protein kinase, DNA-activated,
catalytic polypeptide [Homo sapiens]
Length = 4096
Score = 95.1 bits (235), Expect = 1e-18
Identities = 88/378 (23%), Positives = 150/378 (39%), Gaps = 77/378 (20%)
Query: 2071 FKEIMLSLQQRAQKRASYILRLEEISPWLA----AMTNTEIALPGEVSARDT------VT 2120
F +I L + K + L+E SPW++ E+ +PG+ R V
Sbjct: 3658 FNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVR 3717
Query: 2121 IHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATI 2180
I +T++ + +PK+++ G D + +P+L KG EDL D+R+ Q ++N + A
Sbjct: 3718 IAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQD 3777
Query: 2181 NRQETPRFHARHYSVTPLGT---RSGLIQWVDGATPLFG---------LYKRWQQREAAL 2228
+ R YSV P+ + R+ ++ D T + G +YK + E
Sbjct: 3778 SACSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVT 3837
Query: 2229 QAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELM 2288
+K + SK+ P ++K M
Sbjct: 3838 SFRKRE--------------------SKV------------------PADLLKRAFVR-M 3858
Query: 2289 EATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTG 2348
+P LA + +A S A++ + +I+G+GDRHL+N ++ M TG
Sbjct: 3859 STSPEAFLA---------------LRSHFASSHALICISHWILGIGDRHLNNFMVAMETG 3903
Query: 2349 EVVHIDYNVCFEKG-KSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGR 2407
V+ ID+ F + L VPE +PFR+T+ + G+ L R
Sbjct: 3904 GVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDP 3963
Query: 2408 ETLLTLLEAFVYDPLVDW 2425
L ++ FV +P DW
Sbjct: 3964 GLLTNTMDVFVKEPSFDW 3981
>gi|4507691 transformation/transcription domain-associated protein
[Homo sapiens]
Length = 3830
Score = 58.5 bits (140), Expect = 1e-07
Identities = 107/526 (20%), Positives = 213/526 (40%), Gaps = 76/526 (14%)
Query: 1931 SKIVDKLSSANPTMVLQVQMLVAELRRVTVLWDELWLGVLLQQHMYVLRRIQQLEDEVKR 1990
S+I+ +PT++ ++ +V ++ V + E W H VLR++QQ
Sbjct: 3272 SRIMHMQRELHPTLLSSLEGIVDQM----VWFRENW-------HEEVLRQLQQ------G 3314
Query: 1991 VQNNNTLRKEEKIAIMREKHTA--------LMKPIVFALEHVRSITAAPAETPHEKWFQD 2042
+ ++ E+ A+ K T L+ LE+V +++ + E +
Sbjct: 3315 LAKCYSVAFEKSGAVSDAKITPHTLNFVKKLVSTFGVGLENVSNVSTMFSSAASESLARR 3374
Query: 2043 NYGDAIENALEKLK----TPLNPAKPGSSWI-----PFKEIMLSLQQRAQKRASYILRLE 2093
A + +KLK T + + PGS + K+ + L+ + ++ + L +E
Sbjct: 3375 AQATAQDPVFQKLKGQFTTDFDFSVPGSMKLHNLISKLKKWIKILEAKTKQLPKFFL-IE 3433
Query: 2094 EISPWLAAMT--NTEIALPGE-VSARDT---VTIHSVGGTITILPT-KTKPKKLLFLGSD 2146
E +L+ + E+ +PGE + + T + I + I+ T ++L G +
Sbjct: 3434 EKCRFLSNFSAQTAEVEIPGEFLMPKPTHYYIKIARFMPRVEIVQKHNTAARRLYIRGHN 3493
Query: 2147 GKSYPYLFKG---LEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSG 2203
GK YPYL L + +ER++Q L ++N R+ET + H ++V + S
Sbjct: 3494 GKIYPYLVMNDACLTESRREERVLQLLRLLNPCLE--KRKETTKRHL-FFTVPRVVAVSP 3550
Query: 2204 LIQWVDGATPLFGLYKRWQQREAALQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKT 2263
++ V+ L + ++QR A + P YY ++
Sbjct: 3551 QMRLVEDNPSSLSLVEIYKQRCAKKGIEH--------------DNPISRYYDRLA----- 3591
Query: 2264 VGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPD--EWWRVTQSYARST 2321
++ V++ +L+E+ P + KE W+ T P+ ++W + +
Sbjct: 3592 ---TVQARGTQASHQVLRDILKEVQSNMVPRSMLKE-WALHTFPNATDYWTFRKMFTIQL 3647
Query: 2322 AVMSMVGYIIGLGDRHLDNVLIDMTTGE--VVHIDYNVCFEKGKSLRVPEKVPFRMTQNI 2379
A++ +++ L + + + I TG+ V + +++ G L VPFR+T NI
Sbjct: 3648 ALIGFAEFVLHLNRLNPEMLQIAQDTGKLNVAYFRFDINDATG-DLDANRPVPFRLTPNI 3706
Query: 2380 ETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDW 2425
L GV G S V + + +L+ + D ++ W
Sbjct: 3707 SEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILKTVLRDEIIAW 3752
>gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo
sapiens]
Length = 1070
Score = 58.2 bits (139), Expect = 2e-07
Identities = 48/175 (27%), Positives = 79/175 (45%), Gaps = 15/175 (8%)
Query: 2308 DEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFE--KGKSL 2365
D+ R + + S A + Y++G+GDRH DN+++ TG++ HID+ K K
Sbjct: 892 DDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMV-KKTGQLFHIDFGHILGNFKSKFG 950
Query: 2366 RVPEKVPFRMTQNI-----ETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYD 2420
E+VPF +T + + G T G FR CE I+RR +TL +
Sbjct: 951 IKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTA 1010
Query: 2421 PLVDWTAGGEAGFAGAVYGGGGQQAES-KQSKREMEREITRSLFSSRVAEIKVNW 2474
L + T+ + + G + E+ KQ K++ + + S + KVNW
Sbjct: 1011 GLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTT------KVNW 1059
>gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapiens]
Length = 887
Score = 53.1 bits (126), Expect = 5e-06
Identities = 36/110 (32%), Positives = 53/110 (48%), Gaps = 10/110 (9%)
Query: 2313 VTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVP 2372
V +Y +S A ++ YI+G+GDRHLDN+L+ TG++ HID+ R P+ +P
Sbjct: 721 VMDTYVKSCAGYCVITYILGVGDRHLDNLLL-TKTGKLFHIDFGYILG-----RDPKPLP 774
Query: 2373 FRMTQNIETALGVTGVEG----VFRLSCEQVLHIMRRGRETLLTLLEAFV 2418
M N E G+ G + FR C +RR +L L V
Sbjct: 775 PPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMV 824
Score = 45.1 bits (105), Expect = 0.001
Identities = 24/82 (29%), Positives = 41/82 (50%), Gaps = 4/82 (4%)
Query: 2127 TITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETP 2186
T T+ + P +L F DG YP +FK +DL D+ I+Q +S+++ + R+E
Sbjct: 608 TATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLL----RKENL 663
Query: 2187 RFHARHYSVTPLGTRSGLIQWV 2208
Y V T+ G +Q++
Sbjct: 664 DLKLTPYKVLATSTKHGFMQFI 685
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 45.1 bits (105), Expect = 0.001
Identities = 80/354 (22%), Positives = 132/354 (37%), Gaps = 52/354 (14%)
Query: 3116 DIIAQVEAKDFGAESKVSVDDLCKKAVEHNIQIGKFSQLVMNRA-TVLASSYDTAWKKHD 3174
++ Q+E K ES VS K+A + K N+A LA + ++ D
Sbjct: 1287 ELSRQLEEK----ESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD 1342
Query: 3175 LVRRLETSISSCKTSLQRV----QLHIAMFQWQHEDLLINRPQAMSVTPPPRSAILTSMK 3230
L+R K LQR +A ++ ++E I R + + + K
Sbjct: 1343 LLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELE----------EAKK 1392
Query: 3231 KKLHTLSQIETSIATVQEKLAALESSIEQRLKW-----------AGGANPALAPVLQDFE 3279
K L E + V K A+LE + +QRL+ A AL ++F+
Sbjct: 1393 KLAQRLQDSEEQVEAVNAKCASLEKT-KQRLQGEVEDLMVDVERANSLAAALDKKQRNFD 1451
Query: 3280 ATIAERRNLV----------LKESQRASQVTFLCSNIIH--FESLRTRTAEALNLDAALF 3327
+AE + LKES+ S F N + L T E NL+ +
Sbjct: 1452 KVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIA 1511
Query: 3328 ELIKRCQQMCSFASQFNSSVSELELR------LLQRVDTGLEHPIGSSEWLLSAHKQLTQ 3381
+L ++ + + S ++EL L+ + LEH +L +LTQ
Sbjct: 1512 DLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAK---ILRIQLELTQ 1568
Query: 3382 DMSTQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNRQLGDVKHLLKAMAKD 3435
S EK+++IE + Q V+ +++ L R + L K M D
Sbjct: 1569 VKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGD 1622
Score = 32.3 bits (72), Expect = 8.9
Identities = 34/157 (21%), Positives = 70/157 (44%), Gaps = 14/157 (8%)
Query: 2445 AESKQSKREMEREITRSLFSSRVAEIKVNWFKNRDEMLVVLPKLDGSLDEYLSLQEQLTD 2504
AE K E + E+ SL SR + FK ++ L +L+ E +L++++ D
Sbjct: 1455 AEWKTKCEESQAELEASLKESR--SLSTELFKLKNAYEEALDQLETVKRENKNLEQEIAD 1512
Query: 2505 VEKL---QGKLLEEIEF------LEGAE---GVDHPSHTLQHRYSEHTQLQTQQRAVQEA 2552
+ + GK + E+E LE A+ ++ L+H ++ ++Q + V+
Sbjct: 1513 LTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSE 1572
Query: 2553 IQVKLNEFEQWITHYQAAFNNLEATQLASLLQEISTQ 2589
I K+ E ++ I + + T ++L E+ ++
Sbjct: 1573 IDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSR 1609
>gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypeptide
[Homo sapiens]
Length = 1102
Score = 44.7 bits (104), Expect = 0.002
Identities = 25/84 (29%), Positives = 44/84 (52%), Gaps = 3/84 (3%)
Query: 2306 TPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSL 2365
T +++ + + S A + +++G+GDRH DN++I TG + HID+ KS
Sbjct: 917 TEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMI-TETGNLFHIDFGHILGNYKSF 975
Query: 2366 R--VPEKVPFRMTQNIETALGVTG 2387
E+VPF +T + +G +G
Sbjct: 976 LGINKERVPFVLTPDFLFVMGTSG 999
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 44.7 bits (104), Expect = 0.002
Identities = 68/306 (22%), Positives = 118/306 (38%), Gaps = 45/306 (14%)
Query: 3162 LASSYDTAWKKHDLVRRLETSISSCKTSLQRV----QLHIAMFQWQHEDLLINRPQAMSV 3217
LA + +A DL+R + K LQRV +A ++ ++E I R + +
Sbjct: 1331 LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELE- 1389
Query: 3218 TPPPRSAILTSMKKKLHTLSQIETSIATVQEKLAALESS-------IEQRLKWAGGANPA 3270
+ KK L E ++ V K ++LE + IE + +N A
Sbjct: 1390 ---------EAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1440
Query: 3271 LAPV---LQDFEATIAERRNLV----------LKESQRASQVTFLCSNIIH--FESLRTR 3315
A + ++F+ +AE + KE++ S F N E L T
Sbjct: 1441 AAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETF 1500
Query: 3316 TAEALNLDAALFELIKRCQQMCSFASQFNS-----SVSELELR-LLQRVDTGLEHPIGSS 3369
E NL + +L ++ + + V +LEL+ L+ + LEH G
Sbjct: 1501 KRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGK- 1559
Query: 3370 EWLLSAHKQLTQDMSTQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNRQLGDVKHLL 3429
+L A + Q + EK++++E Q +VD+++T L R +V +
Sbjct: 1560 --ILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVK 1617
Query: 3430 KAMAKD 3435
K M D
Sbjct: 1618 KKMEGD 1623
Score = 34.3 bits (77), Expect = 2.3
Identities = 38/147 (25%), Positives = 74/147 (50%), Gaps = 16/147 (10%)
Query: 2443 QQAESKQSKREMEREITRSLFSSRVAEIKVNWFKNRDEMLVVLPKLDGSLDEYLS-LQEQ 2501
Q+ E QS+ E ++ RSL S+ + ++K N ++ E L + + +L E +S L EQ
Sbjct: 1460 QKYEESQSELESSQKEARSL-STELFKLK-NAYEESLEHLETFKRENKNLQEEISDLTEQ 1517
Query: 2502 LTD-------VEKLQGKLLEEIEFLEGAEGVDHPSHTLQHRYSEHTQLQTQQRAVQEAIQ 2554
L + +EK++ +L E+E LE ++ +L+H + + Q + ++ I+
Sbjct: 1518 LGEGGKNVHELEKVRKQL--EVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE 1575
Query: 2555 VKL----NEFEQWITHYQAAFNNLEAT 2577
KL E EQ ++Q ++L+ +
Sbjct: 1576 RKLAEKDEEMEQAKRNHQRVVDSLQTS 1602
>gi|169218238 PREDICTED: similar to ataxia telangiectasia and Rad3
related protein, partial [Homo sapiens]
Length = 2105
Score = 43.1 bits (100), Expect = 0.005
Identities = 21/47 (44%), Positives = 30/47 (63%)
Query: 2128 ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVN 2174
+ IL + KPKK+ GSDGK Y + K +DL D R+M+F S++N
Sbjct: 2058 VEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLIN 2104
>gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo
sapiens]
Length = 1044
Score = 42.0 bits (97), Expect = 0.011
Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 9/113 (7%)
Query: 2301 WSSCTTPDEWW-RVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCF 2359
W P E R + + S A + Y++G+GDRH DN++I +G++ HID+
Sbjct: 858 WLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMI-RESGQLFHIDFGHFL 916
Query: 2360 E--KGKSLRVPEKVPFRMTQNIETAL--GVTGVEGV---FRLSCEQVLHIMRR 2405
K K E+VPF +T + + G T FR CE+ I+RR
Sbjct: 917 GNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRR 969
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 42.0 bits (97), Expect = 0.011
Identities = 77/391 (19%), Positives = 148/391 (37%), Gaps = 45/391 (11%)
Query: 3171 KKHDLVRRLETSISSCKTSLQRVQLHIAMFQWQHEDLLINRPQAMSVTPPPRSAILTS-- 3228
+K D++ RLE + LQ ++ Q + +LL + +AM P L
Sbjct: 1940 EKTDIIDRLEQELLCASNRLQELEAEQQQIQ-EERELLSRQKEAMKAEAGPVEQQLLQET 1998
Query: 3229 ---MKKKLHTLSQIETSIATVQEKLAALESSIEQR--------------LKWAGGANPAL 3271
MK+KL Q E +Q+++ ALE +E++ L N AL
Sbjct: 1999 EKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQAL 2058
Query: 3272 APVLQDFEATIAER-------RNLVLKESQRASQVTFLCSNIIHFESLRTRTAEALNLDA 3324
L+ + E+ R++ +E Q+ Q + +TR E L
Sbjct: 2059 EKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVE--QLAN 2116
Query: 3325 ALFELIKRCQQMCSFASQFNSSVSEL--ELRLLQRVDTGLEHPIGSSEWLLSAHK-QLTQ 3381
L E +C ++ Q + E E+ L+ LE + L+SA Q +
Sbjct: 2117 HLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL-----LVSADTFQKVE 2171
Query: 3382 DMSTQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNRQLGDVKHLLKAMAKDEEAALA 3441
D A++ + E +E + ++ +D + +T QL + L+ ++ +
Sbjct: 2172 DRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHM 2231
Query: 3442 DGEDVPYENSVR--QFLGEYKSWQDNIQTVLFTLVQAMGQVRSQEHV------EMLQEIT 3493
E E++ R + E K ++D+++ + + ++ +HV +++QE
Sbjct: 2232 QLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKE 2291
Query: 3494 PTLKELKTQSQSIYNNLVSFASPLVTDATNE 3524
+ +L Q + L V + NE
Sbjct: 2292 VEIDQLNEQVTKLQQQLKITTDNKVIEEKNE 2322
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 41.6 bits (96), Expect = 0.015
Identities = 88/493 (17%), Positives = 200/493 (40%), Gaps = 56/493 (11%)
Query: 3177 RRLETSISSCKTSLQRVQLHIAMFQWQHEDLLINRPQAMSVTPPPRSAILTSMKKKLHTL 3236
+RL+ ++ + +Q+++ + + +++ L N L +K L
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKN---------------LEELKISSKRL 810
Query: 3237 SQIETSIATVQEKLAALESSIEQRLKWAGGANPALAPVLQDFEATIAERRNLVLKESQRA 3296
Q+E +++++ + LE +Q K N L + + T+ E N+ + ++
Sbjct: 811 EQLEKENKSLEQETSQLEKDKKQLEK----ENKRLRQQAEIKDTTL-EENNVKIGNLEKE 865
Query: 3297 SQVTFLCSNIIHFESLRTRTAEALNLDAALFELIKRCQQMCSFASQFNSSVSELELRLLQ 3356
++ I +R + E N EL+KR + +L+ Q
Sbjct: 866 NKTLSKEIGIYKESCVRLKELEKENK-----ELVKRATIDIKTLVTLREDLVSEKLKT-Q 919
Query: 3357 RVDTGLE------HPIGSSEWLLSAHKQLTQDMSTQRAIQTEKEQQIETVCETIQNLVDN 3410
+++ LE IG ++ L +Q T D S + ++++ E ++ E + +
Sbjct: 920 QMNNDLEKLTHELEKIGLNKERLLHDEQSTDD-SRYKLLESKLESTLKKSLEIKEEKIAA 978
Query: 3411 IKTVL---TGHNRQLGDVKHLLKAMAKDEEAALADGEDVPYENSVRQFLGEYKSWQDNIQ 3467
++ L T +N+QL + LK + K+ EA ++ S GE W+ Q
Sbjct: 979 LEARLEESTNYNQQL---RQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQ 1035
Query: 3468 TVLFTLVQAMGQVRSQEHVEML-----QEITPTLKELKTQSQSIYNNLVSFASPLVTDAT 3522
L++ ++ E Q + LK+L+TQ+ ++ +++ V+
Sbjct: 1036 ETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQE 1095
Query: 3523 NECSSPTSSATYQPSFAAAVRSNTGQKTQPDVMSQNARKLIQKNLATSADTPPSTVPGTG 3582
+ T +A Q V ++T +M+QNA+ LIQ+ +S + +V
Sbjct: 1096 QNTTLQTQNAKLQ------VENSTLNSQSTSLMNQNAQLLIQQ---SSLENENESVIKER 1146
Query: 3583 KSVACSPKKAVRDPKTGKAVQER--NSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYV 3640
+ + ++D + + + ER + Y + K K ++++ R + ++ + +
Sbjct: 1147 EDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR-DLEDRYNQL 1205
Query: 3641 IKEATNLDNLAQL 3653
+K+ L++L ++
Sbjct: 1206 LKQKGQLEDLEKM 1218
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 41.2 bits (95), Expect = 0.019
Identities = 66/307 (21%), Positives = 115/307 (37%), Gaps = 47/307 (15%)
Query: 3162 LASSYDTAWKKHDLVRRLETSISSCKTSLQRV----QLHIAMFQWQHEDLLINRPQAMSV 3217
LA + +A DL+R + K LQRV +A ++ ++E I R + +
Sbjct: 1329 LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELE- 1387
Query: 3218 TPPPRSAILTSMKKKLHTLSQIETSIATVQEKLAALESS-------IEQRLKWAGGANPA 3270
+ KK L + E ++ V K ++LE + IE + +N A
Sbjct: 1388 ---------EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1438
Query: 3271 LAPV---LQDFEATIAERRNLV----------LKESQRASQVTFLCSNIIH--FESLRTR 3315
A + ++F+ +AE + KE++ S F N E L T
Sbjct: 1439 AAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETF 1498
Query: 3316 TAEALNLDAALFELI-------KRCQQMCSFASQFNSSVSELELRLLQRVDTGLEHPIGS 3368
E NL + +L K ++ Q + EL+ L+ + LEH G
Sbjct: 1499 KRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQ-SALEEAEASLEHEEGK 1557
Query: 3369 SEWLLSAHKQLTQDMSTQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNRQLGDVKHL 3428
+L A + Q + EK++++E +VD+++T L R + +
Sbjct: 1558 ---ILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 1614
Query: 3429 LKAMAKD 3435
K M D
Sbjct: 1615 KKKMEGD 1621
Score = 33.5 bits (75), Expect = 4.0
Identities = 52/283 (18%), Positives = 113/283 (39%), Gaps = 11/283 (3%)
Query: 3224 AILTSMKKKLHTLSQIETSIATVQEKLAALESSIEQRLKWAGGANPALAPVLQDFEATIA 3283
A + ++++L + ++ L+ I +RL+ AGGA + + EA
Sbjct: 1113 ARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ 1172
Query: 3284 ERRNLVLKESQRASQVTFLCSNIIHFESLRTRTAEALNLDAALFELIKRCQQMCSFASQF 3343
+ R L+E+ + T H +S+ + NL +L K + F +
Sbjct: 1173 KMRR-DLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEK---EKSEFKLEL 1228
Query: 3344 NSSVSELELRL-----LQRVDTGLEHPIGSSEWLLSAHKQLTQDMSTQRAIQTEKEQQIE 3398
+ S +E + L+++ LE + ++ D+++QRA + ++
Sbjct: 1229 DDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELS 1288
Query: 3399 TVCETIQNLVDNIKTVLTGHNRQLGDVKHLLKAMAKDEEAALADGEDVPYE-NSVRQFLG 3457
+ + L+ + + +QL D+K L+ K + A + ++ + +R+
Sbjct: 1289 RQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYE 1348
Query: 3458 EYKSWQDNIQTVLFTLVQAMGQVRSQEHVEMLQEITPTLKELK 3500
E + +Q VL + Q R++ + +Q T L+E K
Sbjct: 1349 EETEAKAELQRVLSKANSEVAQWRTKYETDAIQR-TEELEEAK 1390
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 41.2 bits (95), Expect = 0.019
Identities = 74/388 (19%), Positives = 144/388 (37%), Gaps = 47/388 (12%)
Query: 3171 KKHDLVRRLETSISSCKTSLQRVQLHIAMFQWQHEDLLINRPQAMSVTPPPRSAILTS-- 3228
+K D++ RLE + LQ ++ Q + +LL + +AM P L
Sbjct: 1940 EKTDIIDRLEQELLCASNRLQELEAEQQQIQ-EERELLSRQKEAMKAEAGPVEQQLLQET 1998
Query: 3229 ---MKKKLHTLSQIETSIATVQEKLAALESSIEQR--------------LKWAGGANPAL 3271
MK+KL Q E +Q+++ ALE +E++ L N AL
Sbjct: 1999 EKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQAL 2058
Query: 3272 APVLQDFEATIAER-------RNLVLKESQRASQVTFLCSNIIHFESLRTRTAEALNLDA 3324
L+ + E+ R++ +E Q+ Q + +TR E L
Sbjct: 2059 EKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVE--QLAN 2116
Query: 3325 ALFELIKRCQQMCSFASQFNSSVSELELRLLQRVDTGLEHPIGSSEWLLSAHKQLTQDMS 3384
L E +C ++ Q + E + + LE + E L L +D
Sbjct: 2117 HLKEKTDKCSELLLSKEQLQRDIQERNEEIEK-----LEFRVRELEQAL-----LVEDRK 2166
Query: 3385 TQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNRQLGDVKHLLKAMAKDEEAALADGE 3444
A++ + E +E + ++ +D + +T QL + L+ ++ + E
Sbjct: 2167 HFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLE 2226
Query: 3445 DVPYENSVR--QFLGEYKSWQDNIQTVLFTLVQAMGQVRSQEHV------EMLQEITPTL 3496
E++ R + E K ++D+++ + + ++ +HV +++QE +
Sbjct: 2227 IQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEI 2286
Query: 3497 KELKTQSQSIYNNLVSFASPLVTDATNE 3524
+L Q + L V + NE
Sbjct: 2287 DQLNEQVTKLQQQLKITTDNKVIEEKNE 2314
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 40.8 bits (94), Expect = 0.025
Identities = 51/236 (21%), Positives = 96/236 (40%), Gaps = 27/236 (11%)
Query: 3236 LSQIETSIATVQEKLAALESSI-EQRLKWAGGANPALAPVLQDFEATIAERRNLVLKESQ 3294
L + IAT+++ L+ +E + Q + G P+ + D + + + V +
Sbjct: 894 LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKE 953
Query: 3295 RASQVTFLCSNIIHFESLRTRTAEALNLDAALFELIK-----RCQQMCSFASQFNSSVSE 3349
R T SN+ ++++ T E+LN + + E ++ R ++ F +Q + E
Sbjct: 954 RLKTST---SNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLME 1010
Query: 3350 LELRLLQRVDTGLEHPIGSSEWLLSAHKQLTQDMSTQRAIQTEKEQQIETVCETIQN--- 3406
+E + Q + I S E +QL++ T ++Q E ++ ++ + N
Sbjct: 1011 VE-KEKQELQDDKRRAIESME------QQLSELKKTLSSVQNEVQEALQRASTALSNEQQ 1063
Query: 3407 ----LVDNIKTVLTGHNRQLGDVKHLLKAMAKDEEAALADGEDVPYENSVRQFLGE 3458
+ K + N+ + L A D EA A E V SVRQ L E
Sbjct: 1064 ARRDCQEQAKIAVEAQNK----YERELMLHAADVEALQAAKEQVSKMASVRQHLEE 1115
Score = 35.8 bits (81), Expect = 0.80
Identities = 83/387 (21%), Positives = 154/387 (39%), Gaps = 73/387 (18%)
Query: 3172 KHDLVRRLETSISSCKTSLQRVQLHIAMFQWQHEDLLINRPQAMSVTPPPRSAILTSMKK 3231
K + V RLE ++ KTS + +Q H+ EDLL +A SM++
Sbjct: 229 KKEEVSRLEEQMNGLKTSNEHLQKHV-------EDLLTKLKEAKEQQ--------ASMEE 273
Query: 3232 KLHT-------LSQIETSIATVQE----KLAALESSIEQRLKWAGGANPALAPVLQDFEA 3280
K H LS + S A E +L + + LK AG AN A+ L + E
Sbjct: 274 KFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQ 333
Query: 3281 T-------IAERRNLVLKESQRASQV---TFLCSNIIHFESLRTRTAEALNLDAALFELI 3330
+ + E+ + KE + A+ + T I+ E L + A AA+ +++
Sbjct: 334 SKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTA----AAVAKIV 389
Query: 3331 KRCQQMCSFASQFNSSVSELELRLLQ--RVDTGLEHPIGSSEWLLSAHKQLTQDMSTQRA 3388
K ++ + + + +L L L+ R++ L+ + E K+ ++ +
Sbjct: 390 KPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQK 449
Query: 3389 IQTEKEQQIETVCETIQNLVDNI------KTVLTGHNR----QLGDVKHLLKAM------ 3432
++E + IQ L ++ +VL NR Q+ D+ ++ +
Sbjct: 450 AVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEE 509
Query: 3433 ------AKDEEAALADGEDVPYENSVRQFLGEYKSWQDNIQ--TVLFTLVQAMGQVRSQE 3484
+DEE + AD + Q L Y++ ++ Q L ++ +G+ R +E
Sbjct: 510 ARGNHVIRDEEVSSADISS--SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRERE 567
Query: 3485 HVEMLQEITPT-LKELKTQSQSIYNNL 3510
QE T + + EL+ + +S L
Sbjct: 568 E----QETTSSKITELQLKLESALTEL 590
>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
[Homo sapiens]
Length = 1686
Score = 40.4 bits (93), Expect = 0.033
Identities = 33/140 (23%), Positives = 67/140 (47%), Gaps = 11/140 (7%)
Query: 2296 LAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY 2355
LA+ L + +E+ + ++++ S A + Y++G+ DRH DN+++ +TG + HID+
Sbjct: 1211 LAEWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIML-RSTGHMFHIDF 1269
Query: 2356 NVCFEKGKSLR--VPEKVPFRMTQNIETALGVTGVE------GVFRLSCEQVLHIMRRGR 2407
+ ++ PF +T ++ A + G E +F C Q +++R+
Sbjct: 1270 GKFLGHAQMFGSFKRDRAPFVLTSDM--AYVINGGEKPTIRFQLFVDLCCQAYNLIRKQT 1327
Query: 2408 ETLLTLLEAFVYDPLVDWTA 2427
L LL + L + T+
Sbjct: 1328 NLFLNLLSLMIPSGLPELTS 1347
>gi|51093830 bicaudal D homolog 1 isoform 2 [Homo sapiens]
Length = 835
Score = 40.4 bits (93), Expect = 0.033
Identities = 35/139 (25%), Positives = 69/139 (49%), Gaps = 11/139 (7%)
Query: 3383 MSTQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNRQLGDVKHLLKAMAKDEEAALAD 3442
+S QRA E I+ E + + +K++L+ Q+ ++ +LKA + E ALA+
Sbjct: 649 LSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALAN 708
Query: 3443 GEDVPYEN-------SVRQFLGEYKSWQDNIQTVLFTLVQAMGQVRSQEHVEMLQEITPT 3495
++ YEN ++ + E K+ +++ T F+ ++AM R E+V L E+
Sbjct: 709 LKN-KYENEKAMVTETMTKLRNELKALKEDAAT--FSSLRAMFATRCDEYVTQLDEMQRQ 765
Query: 3496 LKELKTQSQSIYNNLVSFA 3514
L + + +++ N L+ A
Sbjct: 766 LAAAEDEKKTL-NTLLRMA 783
>gi|51039802 bicaudal D homolog 1 isoform 1 [Homo sapiens]
Length = 975
Score = 40.4 bits (93), Expect = 0.033
Identities = 35/139 (25%), Positives = 69/139 (49%), Gaps = 11/139 (7%)
Query: 3383 MSTQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNRQLGDVKHLLKAMAKDEEAALAD 3442
+S QRA E I+ E + + +K++L+ Q+ ++ +LKA + E ALA+
Sbjct: 649 LSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALAN 708
Query: 3443 GEDVPYEN-------SVRQFLGEYKSWQDNIQTVLFTLVQAMGQVRSQEHVEMLQEITPT 3495
++ YEN ++ + E K+ +++ T F+ ++AM R E+V L E+
Sbjct: 709 LKN-KYENEKAMVTETMTKLRNELKALKEDAAT--FSSLRAMFATRCDEYVTQLDEMQRQ 765
Query: 3496 LKELKTQSQSIYNNLVSFA 3514
L + + +++ N L+ A
Sbjct: 766 LAAAEDEKKTL-NTLLRMA 783
>gi|198442834 coiled-coil domain containing 152 [Homo sapiens]
Length = 254
Score = 40.4 bits (93), Expect = 0.033
Identities = 39/202 (19%), Positives = 85/202 (42%), Gaps = 25/202 (12%)
Query: 3389 IQTEKEQQIETVCETIQNLVDNIKTV------LTGHNRQLGDVKHLLKAMAKDEEAALAD 3442
+ KE I+ C T+ N++ ++ L G N QL L+K K E
Sbjct: 54 VMQAKEVSIKEECATLHNIIKGLQQTIEYQQNLKGENEQLKISADLIKEKLKSHEQ---- 109
Query: 3443 GEDVPYENSVRQFLGEYKSWQDNIQTVLFTLVQAMG---QVRSQEHVEMLQ----EITPT 3495
Y+N++ + + E K ++ + + L Q M ++ ++H E+++ EI+
Sbjct: 110 ----EYKNNIAKLVSEMKIKEEGYKKEISKLYQDMQRKVELNEEKHKELIEKKEMEISEL 165
Query: 3496 LKELKTQSQSIYNNLV----SFASPLVTDATNECSSPTSSATYQPSFAAAVRSNTGQKTQ 3551
+L++Q + N ++ F + L T S S+ Q + ++ +K +
Sbjct: 166 NAKLRSQEKEKQNEIIKLQLEFDAKLARVQTKSKSYQDSTVLPQSIYRRKLQHFQEEKNK 225
Query: 3552 PDVMSQNARKLIQKNLATSADT 3573
+ +N + +++ L+ D+
Sbjct: 226 EIAILRNTIRDLEQRLSVGKDS 247
>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
[Homo sapiens]
Length = 1634
Score = 40.0 bits (92), Expect = 0.042
Identities = 17/48 (35%), Positives = 31/48 (64%), Gaps = 1/48 (2%)
Query: 2308 DEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY 2355
DE+ + +++ S A + Y++G+ DRH DN+++ TTG + HID+
Sbjct: 1168 DEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIML-KTTGHMFHIDF 1214
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 40.0 bits (92), Expect = 0.042
Identities = 74/399 (18%), Positives = 166/399 (41%), Gaps = 40/399 (10%)
Query: 3114 GVDIIAQVEAKDFGAESKVSVDDLCKKAVEHNIQIGKFSQLVMNRATVLASSYDTAWKKH 3173
G ++ +V ++ S VS++ + E +Q+ K + + L+ A K+
Sbjct: 376 GQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEK 435
Query: 3174 DLVRRLETSISSCKTSLQRVQLHIAMFQWQHEDLLINRPQAMSVTPPPRSAILTSMKKKL 3233
L+ +++ T LQ Q+ + Q +D L S+ + ++K+
Sbjct: 436 ---AELQAQLAALSTKLQ-AQVECSHSSQQRQDSL--------------SSEVDTLKQSC 477
Query: 3234 HTLSQIETSIATVQEKLAALESSIEQRLKWAGGANPALAPVLQDFEATIAERRNLVLKES 3293
L + T + + E A +S L+ A L ++D + ++ + N V
Sbjct: 478 WDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLR 537
Query: 3294 QRASQVTFLCSNIIHFESLRTRTAEALNLDAALFELIKRCQQMCSFASQFNSSVSELELR 3353
Q Q+T L S + + RT L A ++ +Q + Q + E +R
Sbjct: 538 Q---QMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQ---WYQQQLALAQEARVR 591
Query: 3354 L---LQRVDTGLEHPIGSSEWLLSAHKQLTQDMSTQRAIQTEKEQQIETVCETIQ-NLVD 3409
L + + G G E L + L+Q ++ + +++ +I + I+ +++D
Sbjct: 592 LQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLD 651
Query: 3410 NIKTVLTGHNRQLGDVKHLLKAMAKDEEAALADGEDVPYENSVRQFLGEYKSWQDNIQTV 3469
+ Q+ + K +++ +D + L + E +++ S + ++ V
Sbjct: 652 QEAAFM-----QIQEAKTMVE---EDLQRRLEEFEGE--RERLQRMADSAASLEQQLEQV 701
Query: 3470 LFTLVQAMGQVRS--QEHVEMLQEITPTLKELKTQSQSI 3506
TL+Q Q+ + QEH+++++++T T + L+++ QS+
Sbjct: 702 KLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSL 740
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.131 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 132,417,241
Number of Sequences: 37866
Number of extensions: 5707521
Number of successful extensions: 19039
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 133
Number of HSP's that attempted gapping in prelim test: 18495
Number of HSP's gapped (non-prelim): 745
length of query: 3661
length of database: 18,247,518
effective HSP length: 122
effective length of query: 3539
effective length of database: 13,627,866
effective search space: 48229017774
effective search space used: 48229017774
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 72 (32.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.