BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|13540600 nudE nuclear distribution gene E homolog (A. nidulans)-like 1 isoform B [Homo sapiens] (345 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|13540600 nudE nuclear distribution gene E homolog (A. nidulan... 673 0.0 gi|71284108 nudE nuclear distribution gene E homolog (A. nidulan... 611 e-175 gi|221316642 nuclear distribution gene E homolog 1 [Homo sapiens] 339 2e-93 gi|8923110 nuclear distribution gene E homolog 1 [Homo sapiens] 339 2e-93 gi|50658069 phosphodiesterase 4D interacting protein isoform 2 [... 60 4e-09 gi|50658071 phosphodiesterase 4D interacting protein isoform 5 [... 60 4e-09 gi|157311604 phosphodiesterase 4D interacting protein isoform 1 ... 60 4e-09 gi|224451082 cytospin A [Homo sapiens] 58 1e-08 gi|224451080 cytospin A [Homo sapiens] 58 1e-08 gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 57 3e-08 gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 57 3e-08 gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 57 3e-08 gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 57 3e-08 gi|16262452 cingulin [Homo sapiens] 55 9e-08 gi|157743265 caspase recruitment domain family, member 11 [Homo ... 55 9e-08 gi|22208850 Golgi coiled-coil protein 1 [Homo sapiens] 54 2e-07 gi|169217489 PREDICTED: similar to phosphodiesterase 4D interact... 53 3e-07 gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 53 3e-07 gi|32698688 citron [Homo sapiens] 52 6e-07 gi|148746195 trichohyalin [Homo sapiens] 52 8e-07 gi|119120918 coiled-coil domain containing 64 [Homo sapiens] 52 1e-06 gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 51 1e-06 gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 51 1e-06 gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 51 2e-06 gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 51 2e-06 gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 51 2e-06 gi|149363685 hypothetical protein LOC23379 [Homo sapiens] 50 2e-06 gi|109255239 centrosomal protein 63 isoform b [Homo sapiens] 50 2e-06 gi|22095367 centrosomal protein 63 isoform a [Homo sapiens] 50 2e-06 gi|34577114 cytomatrix protein p110 [Homo sapiens] 50 2e-06 >gi|13540600 nudE nuclear distribution gene E homolog (A. nidulans)-like 1 isoform B [Homo sapiens] Length = 345 Score = 673 bits (1736), Expect = 0.0 Identities = 345/345 (100%), Positives = 345/345 (100%) Query: 1 MDGEDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQ 60 MDGEDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQ Sbjct: 1 MDGEDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQ 60 Query: 61 RNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQ 120 RNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQ Sbjct: 61 RNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQ 120 Query: 121 ANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQE 180 ANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQE Sbjct: 121 ANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQE 180 Query: 181 LAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENTFPSPKAIPNGFG 240 LAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENTFPSPKAIPNGFG Sbjct: 181 LAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENTFPSPKAIPNGFG 240 Query: 241 TSPLTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKSYISGNVNCGVLNGNG 300 TSPLTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKSYISGNVNCGVLNGNG Sbjct: 241 TSPLTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKSYISGNVNCGVLNGNG 300 Query: 301 TKFSRSGHTSFFDKGAVNGFDPAPPPPGLGSSRPSSAPGMLPLSV 345 TKFSRSGHTSFFDKGAVNGFDPAPPPPGLGSSRPSSAPGMLPLSV Sbjct: 301 TKFSRSGHTSFFDKGAVNGFDPAPPPPGLGSSRPSSAPGMLPLSV 345 >gi|71284108 nudE nuclear distribution gene E homolog (A. nidulans)-like 1 isoform A [Homo sapiens] Length = 328 Score = 611 bits (1576), Expect = e-175 Identities = 315/315 (100%), Positives = 315/315 (100%) Query: 1 MDGEDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQ 60 MDGEDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQ Sbjct: 1 MDGEDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQ 60 Query: 61 RNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQ 120 RNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQ Sbjct: 61 RNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQ 120 Query: 121 ANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQE 180 ANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQE Sbjct: 121 ANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQE 180 Query: 181 LAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENTFPSPKAIPNGFG 240 LAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENTFPSPKAIPNGFG Sbjct: 181 LAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENTFPSPKAIPNGFG 240 Query: 241 TSPLTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKSYISGNVNCGVLNGNG 300 TSPLTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKSYISGNVNCGVLNGNG Sbjct: 241 TSPLTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKSYISGNVNCGVLNGNG 300 Query: 301 TKFSRSGHTSFFDKG 315 TKFSRSGHTSFFDKG Sbjct: 301 TKFSRSGHTSFFDKG 315 >gi|221316642 nuclear distribution gene E homolog 1 [Homo sapiens] Length = 335 Score = 339 bits (870), Expect = 2e-93 Identities = 181/282 (64%), Positives = 226/282 (80%), Gaps = 8/282 (2%) Query: 9 FSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQAD 68 FSS +EE YWK+L++ YKQ + ++EL EFQEGSRE EAELE QL Q E RNRDL ++ Sbjct: 8 FSSEEEEANYWKDLAMTYKQRAENTQEELREFQEGSREYEAELETQLQQIETRNRDLLSE 67 Query: 69 NQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERA 128 N RL+ E+E +KEK E Q+++ Y+Q+S LEDDL+QT+AIK+QL KY+RELEQANDDLERA Sbjct: 68 NNRLRMELETIKEKFEVQHSEGYRQISALEDDLAQTKAIKDQLQKYIRELEQANDDLERA 127 Query: 129 KRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQ 188 KRATI+SLEDFEQRLNQAIERNAFLESELDEKE+LL SVQRLKDEARDLRQELAV+++ Q Sbjct: 128 KRATIMSLEDFEQRLNQAIERNAFLESELDEKENLLESVQRLKDEARDLRQELAVQQK-Q 186 Query: 189 EVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVG-KGTENTFPSPKAIPNGF----GTSP 243 E R PSS ++ E+ D+AVQA+ S+P+TP+ +G ++ +P + G G +P Sbjct: 187 EKPRTPMPSS--VEAERTDTAVQATGSVPSTPIAHRGPSSSLNTPGSFRRGLDDSTGGTP 244 Query: 244 LTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKS 285 LTP+ARISALNIVGDLLRKVGALESKLA+CRN DQ+ ++ Sbjct: 245 LTPAARISALNIVGDLLRKVGALESKLASCRNLVYDQSPNRT 286 >gi|8923110 nuclear distribution gene E homolog 1 [Homo sapiens] Length = 335 Score = 339 bits (870), Expect = 2e-93 Identities = 181/282 (64%), Positives = 226/282 (80%), Gaps = 8/282 (2%) Query: 9 FSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQAD 68 FSS +EE YWK+L++ YKQ + ++EL EFQEGSRE EAELE QL Q E RNRDL ++ Sbjct: 8 FSSEEEEANYWKDLAMTYKQRAENTQEELREFQEGSREYEAELETQLQQIETRNRDLLSE 67 Query: 69 NQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERA 128 N RL+ E+E +KEK E Q+++ Y+Q+S LEDDL+QT+AIK+QL KY+RELEQANDDLERA Sbjct: 68 NNRLRMELETIKEKFEVQHSEGYRQISALEDDLAQTKAIKDQLQKYIRELEQANDDLERA 127 Query: 129 KRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQ 188 KRATI+SLEDFEQRLNQAIERNAFLESELDEKE+LL SVQRLKDEARDLRQELAV+++ Q Sbjct: 128 KRATIMSLEDFEQRLNQAIERNAFLESELDEKENLLESVQRLKDEARDLRQELAVQQK-Q 186 Query: 189 EVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVG-KGTENTFPSPKAIPNGF----GTSP 243 E R PSS ++ E+ D+AVQA+ S+P+TP+ +G ++ +P + G G +P Sbjct: 187 EKPRTPMPSS--VEAERTDTAVQATGSVPSTPIAHRGPSSSLNTPGSFRRGLDDSTGGTP 244 Query: 244 LTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKS 285 LTP+ARISALNIVGDLLRKVGALESKLA+CRN DQ+ ++ Sbjct: 245 LTPAARISALNIVGDLLRKVGALESKLASCRNLVYDQSPNRT 286 >gi|50658069 phosphodiesterase 4D interacting protein isoform 2 [Homo sapiens] Length = 969 Score = 59.7 bits (143), Expect = 4e-09 Identities = 52/182 (28%), Positives = 95/182 (52%), Gaps = 17/182 (9%) Query: 36 ELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVS 95 + V+F E + E E Q + + N++L+ Q+L+ E++ ++L A+ Y ++ Sbjct: 374 QCVQFVEAAAH---ESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIR 430 Query: 96 VLEDD---LSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAF 152 E + L+ + + KEQL + REL Q D+ ++ A + LE QR++ ++ Sbjct: 431 TQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIH---DKAVA 487 Query: 153 LESELDEKESLLVSVQRLKDEARDLRQ-ELAVRERQQEVTR-KSAPSSPTLDCEKMDSAV 210 LE +DEK S L+++ ++LRQ LAVRER ++ R + SS + M+S + Sbjct: 488 LERAIDEKFS------ALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLL 541 Query: 211 QA 212 +A Sbjct: 542 RA 543 Score = 31.2 bits (69), Expect = 1.4 Identities = 39/186 (20%), Positives = 74/186 (39%), Gaps = 20/186 (10%) Query: 27 KQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYE----------- 75 KQ + + + Q S AEL+ ++ Q E N+ LQ + YE Sbjct: 220 KQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQ 279 Query: 76 ---VEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRAT 132 ++ LKE L+ + ++ + V+E ++E LH+ +L Q + + Sbjct: 280 DGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQ--SQLGQLHSSEGTSPAQQ 337 Query: 133 IVSLEDFEQRLNQAIERNAFLESELDEKESLLVS----VQRLKDEARDLRQELAVRERQQ 188 V+L D + L + L+ + +KE L VQ ++ A + Q+ + Sbjct: 338 QVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHN 397 Query: 189 EVTRKS 194 + RK+ Sbjct: 398 QELRKA 403 >gi|50658071 phosphodiesterase 4D interacting protein isoform 5 [Homo sapiens] Length = 1132 Score = 59.7 bits (143), Expect = 4e-09 Identities = 52/182 (28%), Positives = 95/182 (52%), Gaps = 17/182 (9%) Query: 36 ELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVS 95 + V+F E + E E Q + + N++L+ Q+L+ E++ ++L A+ Y ++ Sbjct: 537 QCVQFVEAAAH---ESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIR 593 Query: 96 VLEDD---LSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAF 152 E + L+ + + KEQL + REL Q D+ ++ A + LE QR++ ++ Sbjct: 594 TQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIH---DKAVA 650 Query: 153 LESELDEKESLLVSVQRLKDEARDLRQ-ELAVRERQQEVTR-KSAPSSPTLDCEKMDSAV 210 LE +DEK S L+++ ++LRQ LAVRER ++ R + SS + M+S + Sbjct: 651 LERAIDEKFS------ALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLL 704 Query: 211 QA 212 +A Sbjct: 705 RA 706 Score = 31.2 bits (69), Expect = 1.4 Identities = 39/186 (20%), Positives = 74/186 (39%), Gaps = 20/186 (10%) Query: 27 KQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYE----------- 75 KQ + + + Q S AEL+ ++ Q E N+ LQ + YE Sbjct: 383 KQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQ 442 Query: 76 ---VEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRAT 132 ++ LKE L+ + ++ + V+E ++E LH+ +L Q + + Sbjct: 443 DGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQ--SQLGQLHSSEGTSPAQQ 500 Query: 133 IVSLEDFEQRLNQAIERNAFLESELDEKESLLVS----VQRLKDEARDLRQELAVRERQQ 188 V+L D + L + L+ + +KE L VQ ++ A + Q+ + Sbjct: 501 QVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHN 560 Query: 189 EVTRKS 194 + RK+ Sbjct: 561 QELRKA 566 >gi|157311604 phosphodiesterase 4D interacting protein isoform 1 [Homo sapiens] Length = 2346 Score = 59.7 bits (143), Expect = 4e-09 Identities = 52/182 (28%), Positives = 95/182 (52%), Gaps = 17/182 (9%) Query: 36 ELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVS 95 + V+F E + E E Q + + N++L+ Q+L+ E++ ++L A+ Y ++ Sbjct: 374 QCVQFVEAAAH---ESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIR 430 Query: 96 VLEDD---LSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAF 152 E + L+ + + KEQL + REL Q D+ ++ A + LE QR++ ++ Sbjct: 431 TQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIH---DKAVA 487 Query: 153 LESELDEKESLLVSVQRLKDEARDLRQ-ELAVRERQQEVTR-KSAPSSPTLDCEKMDSAV 210 LE +DEK S L+++ ++LRQ LAVRER ++ R + SS + M+S + Sbjct: 488 LERAIDEKFS------ALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLL 541 Query: 211 QA 212 +A Sbjct: 542 RA 543 Score = 33.9 bits (76), Expect = 0.22 Identities = 27/107 (25%), Positives = 47/107 (43%), Gaps = 7/107 (6%) Query: 62 NRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQA 121 NR LQA + E E L S + LE +L + ++QL + +RE +Q Sbjct: 1911 NRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQE 1970 Query: 122 NDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQ 168 + +SL++ + RL + L+ + +EK+ L S+Q Sbjct: 1971 VLHFREER----LSLQENDSRLQHKL---VLLQQQCEEKQQLFESLQ 2010 Score = 32.7 bits (73), Expect = 0.49 Identities = 26/115 (22%), Positives = 52/115 (45%), Gaps = 1/115 (0%) Query: 17 AYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEV 76 A +S ++ Q + R+ L+ + +ELE ELE Q V+ +Q DL+ Q + + Sbjct: 1916 AQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFR 1975 Query: 77 EALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRA 131 E E+ +K V +L+ + + + E L ++ E + ++ +A Sbjct: 1976 EERLSLQENDSRLQHKLV-LLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKA 2029 Score = 31.2 bits (69), Expect = 1.4 Identities = 39/186 (20%), Positives = 74/186 (39%), Gaps = 20/186 (10%) Query: 27 KQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYE----------- 75 KQ + + + Q S AEL+ ++ Q E N+ LQ + YE Sbjct: 220 KQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQ 279 Query: 76 ---VEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRAT 132 ++ LKE L+ + ++ + V+E ++E LH+ +L Q + + Sbjct: 280 DGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQ--SQLGQLHSSEGTSPAQQ 337 Query: 133 IVSLEDFEQRLNQAIERNAFLESELDEKESLLVS----VQRLKDEARDLRQELAVRERQQ 188 V+L D + L + L+ + +KE L VQ ++ A + Q+ + Sbjct: 338 QVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHN 397 Query: 189 EVTRKS 194 + RK+ Sbjct: 398 QELRKA 403 >gi|224451082 cytospin A [Homo sapiens] Length = 1117 Score = 57.8 bits (138), Expect = 1e-08 Identities = 60/267 (22%), Positives = 119/267 (44%), Gaps = 39/267 (14%) Query: 10 SSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADN 69 SSL+E+ A+ + + + + + + DE FQE +++ +L L + + + + Sbjct: 624 SSLQEDLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETER 683 Query: 70 QRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELE---------- 119 +K + L++++E A ++ D + + +++Q H RE++ Sbjct: 684 SDMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKTLHRRLREES 743 Query: 120 ----QANDDLERA-------KRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQ 168 Q DL+ A K + D ++RL++A E+N L EL+E +S + Sbjct: 744 AEWRQFQADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELEEIKSRKQEEE 803 Query: 169 --RLKDEARDLRQELAVRERQQEVTRKSAPSS---PTLD--CEKMDSAVQ----ASLSLP 217 R+ + + ++LA + ++R+S+ SS PT+ + DSA Q A+ ++P Sbjct: 804 RGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIP 863 Query: 218 ATPVGKGTENTFPSPKAIPNGFGTSPL 244 TP+ PSP P SP+ Sbjct: 864 RTPLS-------PSPMKTPPAAAVSPM 883 Score = 34.7 bits (78), Expect = 0.13 Identities = 47/179 (26%), Positives = 80/179 (44%), Gaps = 28/179 (15%) Query: 27 KQSFQEARDELVEFQEGSRELE----------AELEAQLVQAEQRNRDLQADNQRLKYEV 76 +Q +EA++ + +E S +E A L A L + + Q + RLK ++ Sbjct: 524 EQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQL 583 Query: 77 EALKEKLEHQYA-QSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQ----ANDDLERAKRA 131 E K+K+ Y+ + S ++D L R KE+ L++ +D R + A Sbjct: 584 ENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDLAHTRNDANRLQDA 643 Query: 132 TIVSLED----FEQRLNQAIE-RNAFLE---SELDEKES----LLVSVQRLKDEARDLR 178 I +ED F++ + IE N LE S+LDEKE+ + ++ L+DE R Sbjct: 644 -IAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERSDMKETIFELEDEVEQHR 701 >gi|224451080 cytospin A [Homo sapiens] Length = 1117 Score = 57.8 bits (138), Expect = 1e-08 Identities = 60/267 (22%), Positives = 119/267 (44%), Gaps = 39/267 (14%) Query: 10 SSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADN 69 SSL+E+ A+ + + + + + + DE FQE +++ +L L + + + + Sbjct: 624 SSLQEDLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETER 683 Query: 70 QRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELE---------- 119 +K + L++++E A ++ D + + +++Q H RE++ Sbjct: 684 SDMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKTLHRRLREES 743 Query: 120 ----QANDDLERA-------KRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQ 168 Q DL+ A K + D ++RL++A E+N L EL+E +S + Sbjct: 744 AEWRQFQADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELEEIKSRKQEEE 803 Query: 169 --RLKDEARDLRQELAVRERQQEVTRKSAPSS---PTLD--CEKMDSAVQ----ASLSLP 217 R+ + + ++LA + ++R+S+ SS PT+ + DSA Q A+ ++P Sbjct: 804 RGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIP 863 Query: 218 ATPVGKGTENTFPSPKAIPNGFGTSPL 244 TP+ PSP P SP+ Sbjct: 864 RTPLS-------PSPMKTPPAAAVSPM 883 Score = 34.7 bits (78), Expect = 0.13 Identities = 47/179 (26%), Positives = 80/179 (44%), Gaps = 28/179 (15%) Query: 27 KQSFQEARDELVEFQEGSRELE----------AELEAQLVQAEQRNRDLQADNQRLKYEV 76 +Q +EA++ + +E S +E A L A L + + Q + RLK ++ Sbjct: 524 EQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQL 583 Query: 77 EALKEKLEHQYA-QSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQ----ANDDLERAKRA 131 E K+K+ Y+ + S ++D L R KE+ L++ +D R + A Sbjct: 584 ENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDLAHTRNDANRLQDA 643 Query: 132 TIVSLED----FEQRLNQAIE-RNAFLE---SELDEKES----LLVSVQRLKDEARDLR 178 I +ED F++ + IE N LE S+LDEKE+ + ++ L+DE R Sbjct: 644 -IAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERSDMKETIFELEDEVEQHR 701 >gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo sapiens] Length = 1972 Score = 56.6 bits (135), Expect = 3e-08 Identities = 51/202 (25%), Positives = 92/202 (45%), Gaps = 11/202 (5%) Query: 11 SLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQ 70 +L EET + + +Q +A +EL E E + +A L+ E+ N DL + + Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1241 Query: 71 RL---KYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRA-IKEQLHKYVRELEQANDDLE 126 L K EVE K+KLE Q + + S D + RA + +++HK E+E L Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCS----DGERARAELNDKVHKLQNEVESVTGMLN 1297 Query: 127 RAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRER 186 A+ I +D +Q + L+ E +K ++ +++L++E L+ +L + Sbjct: 1298 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL---DE 1354 Query: 187 QQEVTRKSAPSSPTLDCEKMDS 208 + E + TL+ + DS Sbjct: 1355 EMEAKQNLERHISTLNIQLSDS 1376 Score = 51.6 bits (122), Expect = 1e-06 Identities = 47/184 (25%), Positives = 88/184 (47%), Gaps = 9/184 (4%) Query: 10 SSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEA---ELEAQLVQAEQRNRDLQ 66 S L EE +E + + EA + V +ELE E+EA+L + E R + LQ Sbjct: 883 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 942 Query: 67 ADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLE 126 A+ +++ ++ L+E+LE + A K L+ + A ++L + ++ N+ L Sbjct: 943 AERKKMAQQMLDLEEQLEEEEAARQK----LQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998 Query: 127 RAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQ-RLKDEARDLRQELAVRE 185 + ++ + D L + E+ L ++ ES++ ++ RLK E + RQEL + Sbjct: 999 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS-RQELEKLK 1057 Query: 186 RQQE 189 R+ E Sbjct: 1058 RKLE 1061 Score = 47.0 bits (110), Expect = 3e-05 Identities = 55/225 (24%), Positives = 92/225 (40%), Gaps = 51/225 (22%) Query: 20 KELSLKYK----QSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLK-- 73 K +S KY ++ EAR++ + +R LE LEA+ + E+ N+ L+A+ + L Sbjct: 1461 KNISSKYADERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLVSS 1519 Query: 74 --------YEVEALKEKLEHQYAQSYKQVSVLEDDLSQT--------------------- 104 +E+E K LE Q + Q+ LED+L T Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1579 Query: 105 ------------RAIKEQLHKYVRELEQANDD---LERAKRATIVSLEDFEQRLNQAIER 149 R ++ QLH+Y ELE AK+ L+D E + + AI+ Sbjct: 1580 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639 Query: 150 NAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKS 194 +L + ++ + QR ++AR R E+ ++ E KS Sbjct: 1640 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684 Score = 42.4 bits (98), Expect = 6e-04 Identities = 49/202 (24%), Positives = 90/202 (44%), Gaps = 11/202 (5%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 LK+E +EL ++ +A D F E +L+A++ +Q ++ +LQA R Sbjct: 1043 LKKEEKSRQELEKLKRKLEGDASD----FHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRA 131 L E+ A K + + +S L++DL RA + + K R+L + + L+ Sbjct: 1099 LDDEI-AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157 Query: 132 TIVSLEDFEQRLNQAIERNAFLESELDEK-ESLLVSVQRLKDEARDLRQELAVRERQQEV 190 T+ S ++ + + L+ LDE+ S VQ ++ + +EL E+ ++ Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT--EQLEQF 1215 Query: 191 TRKSA---PSSPTLDCEKMDSA 209 R A + TL+ E D A Sbjct: 1216 KRAKANLDKNKQTLEKENADLA 1237 Score = 40.4 bits (93), Expect = 0.002 Identities = 41/176 (23%), Positives = 72/176 (40%), Gaps = 5/176 (2%) Query: 14 EETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLK 73 + TA +EL K +Q + L E E+ + QA + + +R K Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219 Query: 74 YEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATI 133 ++ K+ LE + A ++ VL + K++L V+EL+ D ERA+ Sbjct: 1220 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR---- 1275 Query: 134 VSLEDFEQRLNQAIERNAFLESELDEKE-SLLVSVQRLKDEARDLRQELAVRERQQ 188 L D +L +E + +E + K L V L + +D ++ L RQ+ Sbjct: 1276 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331 Score = 40.4 bits (93), Expect = 0.002 Identities = 43/181 (23%), Positives = 83/181 (45%), Gaps = 23/181 (12%) Query: 33 ARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYK 92 +RDE+ + + + LEA L+Q ++ DL A +R + + + KE+L + A S Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQE---DLAA-AERARKQADLEKEELAEELASSLS 1722 Query: 93 QVSVLEDDLSQTRA----IKEQLHKYVRELEQANDDLERAKR---------ATIVSLEDF 139 + L+D+ + A ++E+L + +E +D + +A + AT S Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782 Query: 140 EQRLNQAIER-NAFLESELDEKESLLVS-----VQRLKDEARDLRQELAVRERQQEVTRK 193 + Q +ER N L S+L E E + S + L+ + L +++ R+++ K Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842 Query: 194 S 194 S Sbjct: 1843 S 1843 Score = 38.1 bits (87), Expect = 0.012 Identities = 49/214 (22%), Positives = 95/214 (44%), Gaps = 44/214 (20%) Query: 4 EDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQL-----VQA 58 ++I + + EE A + K K Q+ D+LV + R+L + LE + + A Sbjct: 1399 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1458 Query: 59 EQRNRDLQADNQRLKYEVEAL-KEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRE 117 E++N + ++R + E EA KE A++ ++ +++L +T + L + + Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN---KMLKAEMED 1515 Query: 118 LEQANDD-------LERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKES-------- 162 L + DD LE++KRA +E+ ++++L+E E Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEE--------------MKTQLEELEDELQATEDA 1561 Query: 163 ---LLVSVQRLKDEARDLRQELAVRERQQEVTRK 193 L V++Q LK + ++L R+ Q E R+ Sbjct: 1562 KLRLEVNMQALKGQ---FERDLQARDEQNEEKRR 1592 Score = 37.7 bits (86), Expect = 0.015 Identities = 45/185 (24%), Positives = 83/185 (44%), Gaps = 32/185 (17%) Query: 13 KEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEA---ELEAQLVQAEQRNRDLQADN 69 +E+ +L K++ E L + ++ +ELE +LE ++ DLQA Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078 Query: 70 QRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLER-- 127 LK ++ +E+L+ A+ L+D+++Q K K +RELE DL+ Sbjct: 1079 AELKMQLAKKEEELQAALAR-------LDDEIAQ----KNNALKKIRELEGHISDLQEDL 1127 Query: 128 -AKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRER 186 ++RA E ++ L + +E L++EL++ + Q L+ +R Sbjct: 1128 DSERAARNKAEKQKRDLGEELEA---LKTELEDTLDSTATQQELR------------AKR 1172 Query: 187 QQEVT 191 +QEVT Sbjct: 1173 EQEVT 1177 Score = 37.4 bits (85), Expect = 0.020 Identities = 45/196 (22%), Positives = 85/196 (43%), Gaps = 19/196 (9%) Query: 8 DFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAE---LEAQLVQAE----- 59 D L+E+ A + + +E +EL G L+ E LEA++ Q E Sbjct: 1688 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747 Query: 60 -QRNRDLQADNQR-LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRE 117 Q N + +D R + E L +L + + + K S + Q + ++ +LH E Sbjct: 1748 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH----E 1803 Query: 118 LEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDL 177 +E A ++ ++TI +LE +L + +E+ A + +SL ++LK+ + Sbjct: 1804 MEGA---VKSKFKSTIAALEAKIAQLEEQVEQEA--REKQAATKSLKQKDKKLKEILLQV 1858 Query: 178 RQELAVRERQQEVTRK 193 E + E+ +E K Sbjct: 1859 EDERKMAEQYKEQAEK 1874 Score = 37.0 bits (84), Expect = 0.026 Identities = 42/178 (23%), Positives = 78/178 (43%), Gaps = 19/178 (10%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 L+EET +S K +Q +E R+ L + +L+ E+EA+ ++L+ Sbjct: 1324 LQEETRQKLNVSTKLRQ-LEEERNSLQD------QLDEEMEAK--------QNLERHIST 1368 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRA 131 L ++ K+KL+ +A + V LE+ + + E L + E A D LE+ K Sbjct: 1369 LNIQLSDSKKKLQ-DFAST---VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424 Query: 132 TIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQE 189 L+D L+ + + LE + + + LL + + + D R R++E Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482 Score = 36.6 bits (83), Expect = 0.034 Identities = 22/102 (21%), Positives = 47/102 (46%) Query: 86 QYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQ 145 Q + +++ ED+L +T+ +++ ++ELEQ + L K L+ + + Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905 Query: 146 AIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQ 187 A E L ++ E E +L ++ +E D Q+L ++ Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 947 Score = 36.6 bits (83), Expect = 0.034 Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 33/173 (19%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELE-----------AELEAQLV---- 56 L E A + + K + + Q+ + E + E+E A LEA++ Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828 Query: 57 QAEQRNRDLQADNQRLKYEVEALKEKL-----EHQYAQSYKQVSVLEDDLSQTRAIKEQL 111 Q EQ R+ QA + LK + + LKE L E + A+ YK+ + E ++ + +K QL Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA--EKGNARVKQLKRQL 1886 Query: 112 HKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLL 164 + E ++ N + + +R L++A E N + E++ +S L Sbjct: 1887 EEAEEESQRINANRRKLQR-----------ELDEATESNEAMGREVNALKSKL 1928 Score = 36.2 bits (82), Expect = 0.044 Identities = 45/178 (25%), Positives = 86/178 (48%), Gaps = 34/178 (19%) Query: 28 QSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQY 87 + +E + + QE +L++E A+ +AE++ RDL E+EALK +LE Sbjct: 1111 KKIRELEGHISDLQE---DLDSERAARN-KAEKQKRDLGE-------ELEALKTELEDTL 1159 Query: 88 ----------AQSYKQVSVL-----EDDLSQTRAIKEQLHKYVRELEQANDDLERAKRAT 132 A+ ++V+VL E+ S ++E K+ + +E+ + LE+ KRA Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219 Query: 133 IVSLEDFEQRLNQAIERNAFLESEL----DEKESLLVSVQRLKDEARDLRQELAVRER 186 +L+ +Q L + NA L EL K+ + ++L+ + ++L+ + + ER Sbjct: 1220 -ANLDKNKQTLE---KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1273 Score = 33.5 bits (75), Expect = 0.29 Identities = 45/181 (24%), Positives = 75/181 (41%), Gaps = 22/181 (12%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 LK W L K K Q R E E Q EL+ E Q +AE ++L+ + + Sbjct: 827 LKLRNWQWWRLFTKVKPLLQVTRQE-EEMQAKEDELQKTKERQQ-KAENELKELEQKHSQ 884 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRA 131 L E L+E+L+ + + Y + + L+ A K++L + + E+E Sbjct: 885 LTEEKNLLQEQLQAE-TELYAEAEEMRVRLA---AKKQELEEILHEME------------ 928 Query: 132 TIVSLEDFEQRLNQ-AIERNAFLESELDEKESL-LVSVQRLKDEARDLRQELAVRERQQE 189 LE+ E R Q ER + LD +E L R K + + E +++ + E Sbjct: 929 --ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE 986 Query: 190 V 190 + Sbjct: 987 I 987 Score = 33.5 bits (75), Expect = 0.29 Identities = 28/117 (23%), Positives = 58/117 (49%), Gaps = 9/117 (7%) Query: 68 DNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELE-QANDDLE 126 D Q L E K + + Q ++ + L+D L + K+ L +++ L Q +D + Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378 Query: 127 RAK--RATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQEL 181 + + +T+ +LE+ ++R + IE L + +EK + +++ K+ L+QEL Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIEN---LTQQYEEKAAAYDKLEKTKNR---LQQEL 1429 >gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo sapiens] Length = 1979 Score = 56.6 bits (135), Expect = 3e-08 Identities = 51/202 (25%), Positives = 92/202 (45%), Gaps = 11/202 (5%) Query: 11 SLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQ 70 +L EET + + +Q +A +EL E E + +A L+ E+ N DL + + Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1248 Query: 71 RL---KYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRA-IKEQLHKYVRELEQANDDLE 126 L K EVE K+KLE Q + + S D + RA + +++HK E+E L Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCS----DGERARAELNDKVHKLQNEVESVTGMLN 1304 Query: 127 RAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRER 186 A+ I +D +Q + L+ E +K ++ +++L++E L+ +L + Sbjct: 1305 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL---DE 1361 Query: 187 QQEVTRKSAPSSPTLDCEKMDS 208 + E + TL+ + DS Sbjct: 1362 EMEAKQNLERHISTLNIQLSDS 1383 Score = 51.6 bits (122), Expect = 1e-06 Identities = 47/184 (25%), Positives = 88/184 (47%), Gaps = 9/184 (4%) Query: 10 SSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEA---ELEAQLVQAEQRNRDLQ 66 S L EE +E + + EA + V +ELE E+EA+L + E R + LQ Sbjct: 890 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 949 Query: 67 ADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLE 126 A+ +++ ++ L+E+LE + A K L+ + A ++L + ++ N+ L Sbjct: 950 AERKKMAQQMLDLEEQLEEEEAARQK----LQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005 Query: 127 RAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQ-RLKDEARDLRQELAVRE 185 + ++ + D L + E+ L ++ ES++ ++ RLK E + RQEL + Sbjct: 1006 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS-RQELEKLK 1064 Query: 186 RQQE 189 R+ E Sbjct: 1065 RKLE 1068 Score = 47.0 bits (110), Expect = 3e-05 Identities = 55/225 (24%), Positives = 92/225 (40%), Gaps = 51/225 (22%) Query: 20 KELSLKYK----QSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLK-- 73 K +S KY ++ EAR++ + +R LE LEA+ + E+ N+ L+A+ + L Sbjct: 1468 KNISSKYADERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLVSS 1526 Query: 74 --------YEVEALKEKLEHQYAQSYKQVSVLEDDLSQT--------------------- 104 +E+E K LE Q + Q+ LED+L T Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1586 Query: 105 ------------RAIKEQLHKYVRELEQANDD---LERAKRATIVSLEDFEQRLNQAIER 149 R ++ QLH+Y ELE AK+ L+D E + + AI+ Sbjct: 1587 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646 Query: 150 NAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKS 194 +L + ++ + QR ++AR R E+ ++ E KS Sbjct: 1647 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691 Score = 42.4 bits (98), Expect = 6e-04 Identities = 49/202 (24%), Positives = 90/202 (44%), Gaps = 11/202 (5%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 LK+E +EL ++ +A D F E +L+A++ +Q ++ +LQA R Sbjct: 1050 LKKEEKSRQELEKLKRKLEGDASD----FHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRA 131 L E+ A K + + +S L++DL RA + + K R+L + + L+ Sbjct: 1106 LDDEI-AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164 Query: 132 TIVSLEDFEQRLNQAIERNAFLESELDEK-ESLLVSVQRLKDEARDLRQELAVRERQQEV 190 T+ S ++ + + L+ LDE+ S VQ ++ + +EL E+ ++ Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT--EQLEQF 1222 Query: 191 TRKSA---PSSPTLDCEKMDSA 209 R A + TL+ E D A Sbjct: 1223 KRAKANLDKNKQTLEKENADLA 1244 Score = 40.4 bits (93), Expect = 0.002 Identities = 41/176 (23%), Positives = 72/176 (40%), Gaps = 5/176 (2%) Query: 14 EETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLK 73 + TA +EL K +Q + L E E+ + QA + + +R K Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226 Query: 74 YEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATI 133 ++ K+ LE + A ++ VL + K++L V+EL+ D ERA+ Sbjct: 1227 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR---- 1282 Query: 134 VSLEDFEQRLNQAIERNAFLESELDEKE-SLLVSVQRLKDEARDLRQELAVRERQQ 188 L D +L +E + +E + K L V L + +D ++ L RQ+ Sbjct: 1283 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338 Score = 40.4 bits (93), Expect = 0.002 Identities = 43/181 (23%), Positives = 83/181 (45%), Gaps = 23/181 (12%) Query: 33 ARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYK 92 +RDE+ + + + LEA L+Q ++ DL A +R + + + KE+L + A S Sbjct: 1674 SRDEIFATAKENEKKAKSLEADLMQLQE---DLAA-AERARKQADLEKEELAEELASSLS 1729 Query: 93 QVSVLEDDLSQTRA----IKEQLHKYVRELEQANDDLERAKR---------ATIVSLEDF 139 + L+D+ + A ++E+L + +E +D + +A + AT S Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789 Query: 140 EQRLNQAIER-NAFLESELDEKESLLVS-----VQRLKDEARDLRQELAVRERQQEVTRK 193 + Q +ER N L S+L E E + S + L+ + L +++ R+++ K Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849 Query: 194 S 194 S Sbjct: 1850 S 1850 Score = 38.1 bits (87), Expect = 0.012 Identities = 49/214 (22%), Positives = 95/214 (44%), Gaps = 44/214 (20%) Query: 4 EDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQL-----VQA 58 ++I + + EE A + K K Q+ D+LV + R+L + LE + + A Sbjct: 1406 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1465 Query: 59 EQRNRDLQADNQRLKYEVEAL-KEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRE 117 E++N + ++R + E EA KE A++ ++ +++L +T + L + + Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN---KMLKAEMED 1522 Query: 118 LEQANDD-------LERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKES-------- 162 L + DD LE++KRA +E+ ++++L+E E Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEE--------------MKTQLEELEDELQATEDA 1568 Query: 163 ---LLVSVQRLKDEARDLRQELAVRERQQEVTRK 193 L V++Q LK + ++L R+ Q E R+ Sbjct: 1569 KLRLEVNMQALKGQ---FERDLQARDEQNEEKRR 1599 Score = 37.7 bits (86), Expect = 0.015 Identities = 45/185 (24%), Positives = 83/185 (44%), Gaps = 32/185 (17%) Query: 13 KEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEA---ELEAQLVQAEQRNRDLQADN 69 +E+ +L K++ E L + ++ +ELE +LE ++ DLQA Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085 Query: 70 QRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLER-- 127 LK ++ +E+L+ A+ L+D+++Q K K +RELE DL+ Sbjct: 1086 AELKMQLAKKEEELQAALAR-------LDDEIAQ----KNNALKKIRELEGHISDLQEDL 1134 Query: 128 -AKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRER 186 ++RA E ++ L + +E L++EL++ + Q L+ +R Sbjct: 1135 DSERAARNKAEKQKRDLGEELEA---LKTELEDTLDSTATQQELR------------AKR 1179 Query: 187 QQEVT 191 +QEVT Sbjct: 1180 EQEVT 1184 Score = 37.4 bits (85), Expect = 0.020 Identities = 45/196 (22%), Positives = 85/196 (43%), Gaps = 19/196 (9%) Query: 8 DFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAE---LEAQLVQAE----- 59 D L+E+ A + + +E +EL G L+ E LEA++ Q E Sbjct: 1695 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754 Query: 60 -QRNRDLQADNQR-LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRE 117 Q N + +D R + E L +L + + + K S + Q + ++ +LH E Sbjct: 1755 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH----E 1810 Query: 118 LEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDL 177 +E A ++ ++TI +LE +L + +E+ A + +SL ++LK+ + Sbjct: 1811 MEGA---VKSKFKSTIAALEAKIAQLEEQVEQEA--REKQAATKSLKQKDKKLKEILLQV 1865 Query: 178 RQELAVRERQQEVTRK 193 E + E+ +E K Sbjct: 1866 EDERKMAEQYKEQAEK 1881 Score = 37.0 bits (84), Expect = 0.026 Identities = 42/178 (23%), Positives = 78/178 (43%), Gaps = 19/178 (10%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 L+EET +S K +Q +E R+ L + +L+ E+EA+ ++L+ Sbjct: 1331 LQEETRQKLNVSTKLRQ-LEEERNSLQD------QLDEEMEAK--------QNLERHIST 1375 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRA 131 L ++ K+KL+ +A + V LE+ + + E L + E A D LE+ K Sbjct: 1376 LNIQLSDSKKKLQ-DFAST---VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431 Query: 132 TIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQE 189 L+D L+ + + LE + + + LL + + + D R R++E Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489 Score = 36.6 bits (83), Expect = 0.034 Identities = 22/102 (21%), Positives = 47/102 (46%) Query: 86 QYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQ 145 Q + +++ ED+L +T+ +++ ++ELEQ + L K L+ + + Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912 Query: 146 AIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQ 187 A E L ++ E E +L ++ +E D Q+L ++ Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 954 Score = 36.6 bits (83), Expect = 0.034 Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 33/173 (19%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELE-----------AELEAQLV---- 56 L E A + + K + + Q+ + E + E+E A LEA++ Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835 Query: 57 QAEQRNRDLQADNQRLKYEVEALKEKL-----EHQYAQSYKQVSVLEDDLSQTRAIKEQL 111 Q EQ R+ QA + LK + + LKE L E + A+ YK+ + E ++ + +K QL Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA--EKGNARVKQLKRQL 1893 Query: 112 HKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLL 164 + E ++ N + + +R L++A E N + E++ +S L Sbjct: 1894 EEAEEESQRINANRRKLQR-----------ELDEATESNEAMGREVNALKSKL 1935 Score = 36.2 bits (82), Expect = 0.044 Identities = 45/178 (25%), Positives = 86/178 (48%), Gaps = 34/178 (19%) Query: 28 QSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQY 87 + +E + + QE +L++E A+ +AE++ RDL E+EALK +LE Sbjct: 1118 KKIRELEGHISDLQE---DLDSERAARN-KAEKQKRDLGE-------ELEALKTELEDTL 1166 Query: 88 ----------AQSYKQVSVL-----EDDLSQTRAIKEQLHKYVRELEQANDDLERAKRAT 132 A+ ++V+VL E+ S ++E K+ + +E+ + LE+ KRA Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226 Query: 133 IVSLEDFEQRLNQAIERNAFLESEL----DEKESLLVSVQRLKDEARDLRQELAVRER 186 +L+ +Q L + NA L EL K+ + ++L+ + ++L+ + + ER Sbjct: 1227 -ANLDKNKQTLE---KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1280 Score = 33.5 bits (75), Expect = 0.29 Identities = 45/181 (24%), Positives = 75/181 (41%), Gaps = 22/181 (12%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 LK W L K K Q R E E Q EL+ E Q +AE ++L+ + + Sbjct: 834 LKLRNWQWWRLFTKVKPLLQVTRQE-EEMQAKEDELQKTKERQQ-KAENELKELEQKHSQ 891 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRA 131 L E L+E+L+ + + Y + + L+ A K++L + + E+E Sbjct: 892 LTEEKNLLQEQLQAE-TELYAEAEEMRVRLA---AKKQELEEILHEME------------ 935 Query: 132 TIVSLEDFEQRLNQ-AIERNAFLESELDEKESL-LVSVQRLKDEARDLRQELAVRERQQE 189 LE+ E R Q ER + LD +E L R K + + E +++ + E Sbjct: 936 --ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE 993 Query: 190 V 190 + Sbjct: 994 I 994 Score = 33.5 bits (75), Expect = 0.29 Identities = 28/117 (23%), Positives = 58/117 (49%), Gaps = 9/117 (7%) Query: 68 DNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELE-QANDDLE 126 D Q L E K + + Q ++ + L+D L + K+ L +++ L Q +D + Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385 Query: 127 RAK--RATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQEL 181 + + +T+ +LE+ ++R + IE L + +EK + +++ K+ L+QEL Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIEN---LTQQYEEKAAAYDKLEKTKNR---LQQEL 1436 >gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo sapiens] Length = 1945 Score = 56.6 bits (135), Expect = 3e-08 Identities = 51/202 (25%), Positives = 92/202 (45%), Gaps = 11/202 (5%) Query: 11 SLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQ 70 +L EET + + +Q +A +EL E E + +A L+ E+ N DL + + Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1248 Query: 71 RL---KYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRA-IKEQLHKYVRELEQANDDLE 126 L K EVE K+KLE Q + + S D + RA + +++HK E+E L Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCS----DGERARAELNDKVHKLQNEVESVTGMLN 1304 Query: 127 RAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRER 186 A+ I +D +Q + L+ E +K ++ +++L++E L+ +L + Sbjct: 1305 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL---DE 1361 Query: 187 QQEVTRKSAPSSPTLDCEKMDS 208 + E + TL+ + DS Sbjct: 1362 EMEAKQNLERHISTLNIQLSDS 1383 Score = 51.6 bits (122), Expect = 1e-06 Identities = 47/184 (25%), Positives = 88/184 (47%), Gaps = 9/184 (4%) Query: 10 SSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEA---ELEAQLVQAEQRNRDLQ 66 S L EE +E + + EA + V +ELE E+EA+L + E R + LQ Sbjct: 890 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 949 Query: 67 ADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLE 126 A+ +++ ++ L+E+LE + A K L+ + A ++L + ++ N+ L Sbjct: 950 AERKKMAQQMLDLEEQLEEEEAARQK----LQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005 Query: 127 RAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQ-RLKDEARDLRQELAVRE 185 + ++ + D L + E+ L ++ ES++ ++ RLK E + RQEL + Sbjct: 1006 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS-RQELEKLK 1064 Query: 186 RQQE 189 R+ E Sbjct: 1065 RKLE 1068 Score = 47.0 bits (110), Expect = 3e-05 Identities = 55/225 (24%), Positives = 92/225 (40%), Gaps = 51/225 (22%) Query: 20 KELSLKYK----QSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLK-- 73 K +S KY ++ EAR++ + +R LE LEA+ + E+ N+ L+A+ + L Sbjct: 1468 KNISSKYADERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLVSS 1526 Query: 74 --------YEVEALKEKLEHQYAQSYKQVSVLEDDLSQT--------------------- 104 +E+E K LE Q + Q+ LED+L T Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1586 Query: 105 ------------RAIKEQLHKYVRELEQANDD---LERAKRATIVSLEDFEQRLNQAIER 149 R ++ QLH+Y ELE AK+ L+D E + + AI+ Sbjct: 1587 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646 Query: 150 NAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKS 194 +L + ++ + QR ++AR R E+ ++ E KS Sbjct: 1647 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691 Score = 42.4 bits (98), Expect = 6e-04 Identities = 49/202 (24%), Positives = 90/202 (44%), Gaps = 11/202 (5%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 LK+E +EL ++ +A D F E +L+A++ +Q ++ +LQA R Sbjct: 1050 LKKEEKSRQELEKLKRKLEGDASD----FHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRA 131 L E+ A K + + +S L++DL RA + + K R+L + + L+ Sbjct: 1106 LDDEI-AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164 Query: 132 TIVSLEDFEQRLNQAIERNAFLESELDEK-ESLLVSVQRLKDEARDLRQELAVRERQQEV 190 T+ S ++ + + L+ LDE+ S VQ ++ + +EL E+ ++ Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT--EQLEQF 1222 Query: 191 TRKSA---PSSPTLDCEKMDSA 209 R A + TL+ E D A Sbjct: 1223 KRAKANLDKNKQTLEKENADLA 1244 Score = 40.4 bits (93), Expect = 0.002 Identities = 41/176 (23%), Positives = 72/176 (40%), Gaps = 5/176 (2%) Query: 14 EETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLK 73 + TA +EL K +Q + L E E+ + QA + + +R K Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226 Query: 74 YEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATI 133 ++ K+ LE + A ++ VL + K++L V+EL+ D ERA+ Sbjct: 1227 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR---- 1282 Query: 134 VSLEDFEQRLNQAIERNAFLESELDEKE-SLLVSVQRLKDEARDLRQELAVRERQQ 188 L D +L +E + +E + K L V L + +D ++ L RQ+ Sbjct: 1283 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338 Score = 40.4 bits (93), Expect = 0.002 Identities = 43/181 (23%), Positives = 83/181 (45%), Gaps = 23/181 (12%) Query: 33 ARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYK 92 +RDE+ + + + LEA L+Q ++ DL A +R + + + KE+L + A S Sbjct: 1674 SRDEIFATAKENEKKAKSLEADLMQLQE---DLAA-AERARKQADLEKEELAEELASSLS 1729 Query: 93 QVSVLEDDLSQTRA----IKEQLHKYVRELEQANDDLERAKR---------ATIVSLEDF 139 + L+D+ + A ++E+L + +E +D + +A + AT S Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789 Query: 140 EQRLNQAIER-NAFLESELDEKESLLVS-----VQRLKDEARDLRQELAVRERQQEVTRK 193 + Q +ER N L S+L E E + S + L+ + L +++ R+++ K Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849 Query: 194 S 194 S Sbjct: 1850 S 1850 Score = 38.1 bits (87), Expect = 0.012 Identities = 49/214 (22%), Positives = 95/214 (44%), Gaps = 44/214 (20%) Query: 4 EDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQL-----VQA 58 ++I + + EE A + K K Q+ D+LV + R+L + LE + + A Sbjct: 1406 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1465 Query: 59 EQRNRDLQADNQRLKYEVEAL-KEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRE 117 E++N + ++R + E EA KE A++ ++ +++L +T + L + + Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN---KMLKAEMED 1522 Query: 118 LEQANDD-------LERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKES-------- 162 L + DD LE++KRA +E+ ++++L+E E Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEE--------------MKTQLEELEDELQATEDA 1568 Query: 163 ---LLVSVQRLKDEARDLRQELAVRERQQEVTRK 193 L V++Q LK + ++L R+ Q E R+ Sbjct: 1569 KLRLEVNMQALKGQ---FERDLQARDEQNEEKRR 1599 Score = 37.7 bits (86), Expect = 0.015 Identities = 45/185 (24%), Positives = 83/185 (44%), Gaps = 32/185 (17%) Query: 13 KEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEA---ELEAQLVQAEQRNRDLQADN 69 +E+ +L K++ E L + ++ +ELE +LE ++ DLQA Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085 Query: 70 QRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLER-- 127 LK ++ +E+L+ A+ L+D+++Q K K +RELE DL+ Sbjct: 1086 AELKMQLAKKEEELQAALAR-------LDDEIAQ----KNNALKKIRELEGHISDLQEDL 1134 Query: 128 -AKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRER 186 ++RA E ++ L + +E L++EL++ + Q L+ +R Sbjct: 1135 DSERAARNKAEKQKRDLGEELEA---LKTELEDTLDSTATQQELR------------AKR 1179 Query: 187 QQEVT 191 +QEVT Sbjct: 1180 EQEVT 1184 Score = 37.4 bits (85), Expect = 0.020 Identities = 45/196 (22%), Positives = 85/196 (43%), Gaps = 19/196 (9%) Query: 8 DFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAE---LEAQLVQAE----- 59 D L+E+ A + + +E +EL G L+ E LEA++ Q E Sbjct: 1695 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754 Query: 60 -QRNRDLQADNQR-LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRE 117 Q N + +D R + E L +L + + + K S + Q + ++ +LH E Sbjct: 1755 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH----E 1810 Query: 118 LEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDL 177 +E A ++ ++TI +LE +L + +E+ A + +SL ++LK+ + Sbjct: 1811 MEGA---VKSKFKSTIAALEAKIAQLEEQVEQEA--REKQAATKSLKQKDKKLKEILLQV 1865 Query: 178 RQELAVRERQQEVTRK 193 E + E+ +E K Sbjct: 1866 EDERKMAEQYKEQAEK 1881 Score = 37.0 bits (84), Expect = 0.026 Identities = 42/178 (23%), Positives = 78/178 (43%), Gaps = 19/178 (10%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 L+EET +S K +Q +E R+ L + +L+ E+EA+ ++L+ Sbjct: 1331 LQEETRQKLNVSTKLRQ-LEEERNSLQD------QLDEEMEAK--------QNLERHIST 1375 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRA 131 L ++ K+KL+ +A + V LE+ + + E L + E A D LE+ K Sbjct: 1376 LNIQLSDSKKKLQ-DFAST---VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431 Query: 132 TIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQE 189 L+D L+ + + LE + + + LL + + + D R R++E Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489 Score = 36.6 bits (83), Expect = 0.034 Identities = 22/102 (21%), Positives = 47/102 (46%) Query: 86 QYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQ 145 Q + +++ ED+L +T+ +++ ++ELEQ + L K L+ + + Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912 Query: 146 AIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQ 187 A E L ++ E E +L ++ +E D Q+L ++ Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 954 Score = 36.6 bits (83), Expect = 0.034 Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 33/173 (19%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELE-----------AELEAQLV---- 56 L E A + + K + + Q+ + E + E+E A LEA++ Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835 Query: 57 QAEQRNRDLQADNQRLKYEVEALKEKL-----EHQYAQSYKQVSVLEDDLSQTRAIKEQL 111 Q EQ R+ QA + LK + + LKE L E + A+ YK+ + E ++ + +K QL Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA--EKGNARVKQLKRQL 1893 Query: 112 HKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLL 164 + E ++ N + + +R L++A E N + E++ +S L Sbjct: 1894 EEAEEESQRINANRRKLQR-----------ELDEATESNEAMGREVNALKSKL 1935 Score = 36.2 bits (82), Expect = 0.044 Identities = 45/178 (25%), Positives = 86/178 (48%), Gaps = 34/178 (19%) Query: 28 QSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQY 87 + +E + + QE +L++E A+ +AE++ RDL E+EALK +LE Sbjct: 1118 KKIRELEGHISDLQE---DLDSERAARN-KAEKQKRDLGE-------ELEALKTELEDTL 1166 Query: 88 ----------AQSYKQVSVL-----EDDLSQTRAIKEQLHKYVRELEQANDDLERAKRAT 132 A+ ++V+VL E+ S ++E K+ + +E+ + LE+ KRA Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226 Query: 133 IVSLEDFEQRLNQAIERNAFLESEL----DEKESLLVSVQRLKDEARDLRQELAVRER 186 +L+ +Q L + NA L EL K+ + ++L+ + ++L+ + + ER Sbjct: 1227 -ANLDKNKQTLE---KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1280 Score = 33.5 bits (75), Expect = 0.29 Identities = 45/181 (24%), Positives = 75/181 (41%), Gaps = 22/181 (12%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 LK W L K K Q R E E Q EL+ E Q +AE ++L+ + + Sbjct: 834 LKLRNWQWWRLFTKVKPLLQVTRQE-EEMQAKEDELQKTKERQQ-KAENELKELEQKHSQ 891 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRA 131 L E L+E+L+ + + Y + + L+ A K++L + + E+E Sbjct: 892 LTEEKNLLQEQLQAE-TELYAEAEEMRVRLA---AKKQELEEILHEME------------ 935 Query: 132 TIVSLEDFEQRLNQ-AIERNAFLESELDEKESL-LVSVQRLKDEARDLRQELAVRERQQE 189 LE+ E R Q ER + LD +E L R K + + E +++ + E Sbjct: 936 --ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE 993 Query: 190 V 190 + Sbjct: 994 I 994 Score = 33.5 bits (75), Expect = 0.29 Identities = 28/117 (23%), Positives = 58/117 (49%), Gaps = 9/117 (7%) Query: 68 DNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELE-QANDDLE 126 D Q L E K + + Q ++ + L+D L + K+ L +++ L Q +D + Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385 Query: 127 RAK--RATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQEL 181 + + +T+ +LE+ ++R + IE L + +EK + +++ K+ L+QEL Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIEN---LTQQYEEKAAAYDKLEKTKNR---LQQEL 1436 >gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo sapiens] Length = 1938 Score = 56.6 bits (135), Expect = 3e-08 Identities = 51/202 (25%), Positives = 92/202 (45%), Gaps = 11/202 (5%) Query: 11 SLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQ 70 +L EET + + +Q +A +EL E E + +A L+ E+ N DL + + Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1241 Query: 71 RL---KYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRA-IKEQLHKYVRELEQANDDLE 126 L K EVE K+KLE Q + + S D + RA + +++HK E+E L Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCS----DGERARAELNDKVHKLQNEVESVTGMLN 1297 Query: 127 RAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRER 186 A+ I +D +Q + L+ E +K ++ +++L++E L+ +L + Sbjct: 1298 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL---DE 1354 Query: 187 QQEVTRKSAPSSPTLDCEKMDS 208 + E + TL+ + DS Sbjct: 1355 EMEAKQNLERHISTLNIQLSDS 1376 Score = 51.6 bits (122), Expect = 1e-06 Identities = 47/184 (25%), Positives = 88/184 (47%), Gaps = 9/184 (4%) Query: 10 SSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEA---ELEAQLVQAEQRNRDLQ 66 S L EE +E + + EA + V +ELE E+EA+L + E R + LQ Sbjct: 883 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 942 Query: 67 ADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLE 126 A+ +++ ++ L+E+LE + A K L+ + A ++L + ++ N+ L Sbjct: 943 AERKKMAQQMLDLEEQLEEEEAARQK----LQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998 Query: 127 RAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQ-RLKDEARDLRQELAVRE 185 + ++ + D L + E+ L ++ ES++ ++ RLK E + RQEL + Sbjct: 999 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS-RQELEKLK 1057 Query: 186 RQQE 189 R+ E Sbjct: 1058 RKLE 1061 Score = 47.0 bits (110), Expect = 3e-05 Identities = 55/225 (24%), Positives = 92/225 (40%), Gaps = 51/225 (22%) Query: 20 KELSLKYK----QSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLK-- 73 K +S KY ++ EAR++ + +R LE LEA+ + E+ N+ L+A+ + L Sbjct: 1461 KNISSKYADERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLVSS 1519 Query: 74 --------YEVEALKEKLEHQYAQSYKQVSVLEDDLSQT--------------------- 104 +E+E K LE Q + Q+ LED+L T Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1579 Query: 105 ------------RAIKEQLHKYVRELEQANDD---LERAKRATIVSLEDFEQRLNQAIER 149 R ++ QLH+Y ELE AK+ L+D E + + AI+ Sbjct: 1580 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639 Query: 150 NAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKS 194 +L + ++ + QR ++AR R E+ ++ E KS Sbjct: 1640 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684 Score = 42.4 bits (98), Expect = 6e-04 Identities = 49/202 (24%), Positives = 90/202 (44%), Gaps = 11/202 (5%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 LK+E +EL ++ +A D F E +L+A++ +Q ++ +LQA R Sbjct: 1043 LKKEEKSRQELEKLKRKLEGDASD----FHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRA 131 L E+ A K + + +S L++DL RA + + K R+L + + L+ Sbjct: 1099 LDDEI-AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157 Query: 132 TIVSLEDFEQRLNQAIERNAFLESELDEK-ESLLVSVQRLKDEARDLRQELAVRERQQEV 190 T+ S ++ + + L+ LDE+ S VQ ++ + +EL E+ ++ Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT--EQLEQF 1215 Query: 191 TRKSA---PSSPTLDCEKMDSA 209 R A + TL+ E D A Sbjct: 1216 KRAKANLDKNKQTLEKENADLA 1237 Score = 40.4 bits (93), Expect = 0.002 Identities = 41/176 (23%), Positives = 72/176 (40%), Gaps = 5/176 (2%) Query: 14 EETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLK 73 + TA +EL K +Q + L E E+ + QA + + +R K Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219 Query: 74 YEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATI 133 ++ K+ LE + A ++ VL + K++L V+EL+ D ERA+ Sbjct: 1220 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR---- 1275 Query: 134 VSLEDFEQRLNQAIERNAFLESELDEKE-SLLVSVQRLKDEARDLRQELAVRERQQ 188 L D +L +E + +E + K L V L + +D ++ L RQ+ Sbjct: 1276 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331 Score = 40.4 bits (93), Expect = 0.002 Identities = 43/181 (23%), Positives = 83/181 (45%), Gaps = 23/181 (12%) Query: 33 ARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYK 92 +RDE+ + + + LEA L+Q ++ DL A +R + + + KE+L + A S Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQE---DLAA-AERARKQADLEKEELAEELASSLS 1722 Query: 93 QVSVLEDDLSQTRA----IKEQLHKYVRELEQANDDLERAKR---------ATIVSLEDF 139 + L+D+ + A ++E+L + +E +D + +A + AT S Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782 Query: 140 EQRLNQAIER-NAFLESELDEKESLLVS-----VQRLKDEARDLRQELAVRERQQEVTRK 193 + Q +ER N L S+L E E + S + L+ + L +++ R+++ K Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842 Query: 194 S 194 S Sbjct: 1843 S 1843 Score = 38.1 bits (87), Expect = 0.012 Identities = 49/214 (22%), Positives = 95/214 (44%), Gaps = 44/214 (20%) Query: 4 EDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQL-----VQA 58 ++I + + EE A + K K Q+ D+LV + R+L + LE + + A Sbjct: 1399 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1458 Query: 59 EQRNRDLQADNQRLKYEVEAL-KEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRE 117 E++N + ++R + E EA KE A++ ++ +++L +T + L + + Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN---KMLKAEMED 1515 Query: 118 LEQANDD-------LERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKES-------- 162 L + DD LE++KRA +E+ ++++L+E E Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEE--------------MKTQLEELEDELQATEDA 1561 Query: 163 ---LLVSVQRLKDEARDLRQELAVRERQQEVTRK 193 L V++Q LK + ++L R+ Q E R+ Sbjct: 1562 KLRLEVNMQALKGQ---FERDLQARDEQNEEKRR 1592 Score = 37.7 bits (86), Expect = 0.015 Identities = 45/185 (24%), Positives = 83/185 (44%), Gaps = 32/185 (17%) Query: 13 KEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEA---ELEAQLVQAEQRNRDLQADN 69 +E+ +L K++ E L + ++ +ELE +LE ++ DLQA Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078 Query: 70 QRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLER-- 127 LK ++ +E+L+ A+ L+D+++Q K K +RELE DL+ Sbjct: 1079 AELKMQLAKKEEELQAALAR-------LDDEIAQ----KNNALKKIRELEGHISDLQEDL 1127 Query: 128 -AKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRER 186 ++RA E ++ L + +E L++EL++ + Q L+ +R Sbjct: 1128 DSERAARNKAEKQKRDLGEELEA---LKTELEDTLDSTATQQELR------------AKR 1172 Query: 187 QQEVT 191 +QEVT Sbjct: 1173 EQEVT 1177 Score = 37.4 bits (85), Expect = 0.020 Identities = 45/196 (22%), Positives = 85/196 (43%), Gaps = 19/196 (9%) Query: 8 DFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAE---LEAQLVQAE----- 59 D L+E+ A + + +E +EL G L+ E LEA++ Q E Sbjct: 1688 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747 Query: 60 -QRNRDLQADNQR-LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRE 117 Q N + +D R + E L +L + + + K S + Q + ++ +LH E Sbjct: 1748 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH----E 1803 Query: 118 LEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDL 177 +E A ++ ++TI +LE +L + +E+ A + +SL ++LK+ + Sbjct: 1804 MEGA---VKSKFKSTIAALEAKIAQLEEQVEQEA--REKQAATKSLKQKDKKLKEILLQV 1858 Query: 178 RQELAVRERQQEVTRK 193 E + E+ +E K Sbjct: 1859 EDERKMAEQYKEQAEK 1874 Score = 37.0 bits (84), Expect = 0.026 Identities = 42/178 (23%), Positives = 78/178 (43%), Gaps = 19/178 (10%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 L+EET +S K +Q +E R+ L + +L+ E+EA+ ++L+ Sbjct: 1324 LQEETRQKLNVSTKLRQ-LEEERNSLQD------QLDEEMEAK--------QNLERHIST 1368 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRA 131 L ++ K+KL+ +A + V LE+ + + E L + E A D LE+ K Sbjct: 1369 LNIQLSDSKKKLQ-DFAST---VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424 Query: 132 TIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQE 189 L+D L+ + + LE + + + LL + + + D R R++E Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482 Score = 36.6 bits (83), Expect = 0.034 Identities = 22/102 (21%), Positives = 47/102 (46%) Query: 86 QYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQ 145 Q + +++ ED+L +T+ +++ ++ELEQ + L K L+ + + Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905 Query: 146 AIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQ 187 A E L ++ E E +L ++ +E D Q+L ++ Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 947 Score = 36.6 bits (83), Expect = 0.034 Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 33/173 (19%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELE-----------AELEAQLV---- 56 L E A + + K + + Q+ + E + E+E A LEA++ Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828 Query: 57 QAEQRNRDLQADNQRLKYEVEALKEKL-----EHQYAQSYKQVSVLEDDLSQTRAIKEQL 111 Q EQ R+ QA + LK + + LKE L E + A+ YK+ + E ++ + +K QL Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA--EKGNARVKQLKRQL 1886 Query: 112 HKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLL 164 + E ++ N + + +R L++A E N + E++ +S L Sbjct: 1887 EEAEEESQRINANRRKLQR-----------ELDEATESNEAMGREVNALKSKL 1928 Score = 36.2 bits (82), Expect = 0.044 Identities = 45/178 (25%), Positives = 86/178 (48%), Gaps = 34/178 (19%) Query: 28 QSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQY 87 + +E + + QE +L++E A+ +AE++ RDL E+EALK +LE Sbjct: 1111 KKIRELEGHISDLQE---DLDSERAARN-KAEKQKRDLGE-------ELEALKTELEDTL 1159 Query: 88 ----------AQSYKQVSVL-----EDDLSQTRAIKEQLHKYVRELEQANDDLERAKRAT 132 A+ ++V+VL E+ S ++E K+ + +E+ + LE+ KRA Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219 Query: 133 IVSLEDFEQRLNQAIERNAFLESEL----DEKESLLVSVQRLKDEARDLRQELAVRER 186 +L+ +Q L + NA L EL K+ + ++L+ + ++L+ + + ER Sbjct: 1220 -ANLDKNKQTLE---KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1273 Score = 33.5 bits (75), Expect = 0.29 Identities = 45/181 (24%), Positives = 75/181 (41%), Gaps = 22/181 (12%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 LK W L K K Q R E E Q EL+ E Q +AE ++L+ + + Sbjct: 827 LKLRNWQWWRLFTKVKPLLQVTRQE-EEMQAKEDELQKTKERQQ-KAENELKELEQKHSQ 884 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRA 131 L E L+E+L+ + + Y + + L+ A K++L + + E+E Sbjct: 885 LTEEKNLLQEQLQAE-TELYAEAEEMRVRLA---AKKQELEEILHEME------------ 928 Query: 132 TIVSLEDFEQRLNQ-AIERNAFLESELDEKESL-LVSVQRLKDEARDLRQELAVRERQQE 189 LE+ E R Q ER + LD +E L R K + + E +++ + E Sbjct: 929 --ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE 986 Query: 190 V 190 + Sbjct: 987 I 987 Score = 33.5 bits (75), Expect = 0.29 Identities = 28/117 (23%), Positives = 58/117 (49%), Gaps = 9/117 (7%) Query: 68 DNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELE-QANDDLE 126 D Q L E K + + Q ++ + L+D L + K+ L +++ L Q +D + Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378 Query: 127 RAK--RATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQEL 181 + + +T+ +LE+ ++R + IE L + +EK + +++ K+ L+QEL Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIEN---LTQQYEEKAAAYDKLEKTKNR---LQQEL 1429 >gi|16262452 cingulin [Homo sapiens] Length = 1203 Score = 55.1 bits (131), Expect = 9e-08 Identities = 49/222 (22%), Positives = 94/222 (42%), Gaps = 43/222 (19%) Query: 8 DFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAEL--EAQLVQAEQRNRDL 65 + EET +W+ + K K+ + + EL++ + E+E EL + +++Q E Sbjct: 560 ELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARA 619 Query: 66 QADNQRLKYEVEALKEKL---------------------EHQYAQSYKQVSVLEDDLSQT 104 A + R +VE LK++L H+ + KQ++VL + + Sbjct: 620 SAGDTR---QVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRG 676 Query: 105 RAIKEQLHKYVRELEQANDDLERAKRATIV-----------------SLEDFEQRLNQAI 147 R ++EQ + + L+Q D E A +A +V +L + ++ ++ Sbjct: 677 RELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFR 736 Query: 148 ERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQE 189 R LE +L E L+ + ++ RD Q L ++Q E Sbjct: 737 RRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLE 778 Score = 48.9 bits (115), Expect = 7e-06 Identities = 39/166 (23%), Positives = 71/166 (42%), Gaps = 1/166 (0%) Query: 28 QSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQY 87 Q + + +L E S+E E L A E R + Q RL E + L LE + Sbjct: 768 QRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEG 827 Query: 88 AQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAI 147 Q + Q R + + + +ELE+ +D ++A + LED++++ + + Sbjct: 828 KQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREV 887 Query: 148 -ERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTR 192 + + E E + RL+DE + LRQ L + +++ R Sbjct: 888 ADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTAR 933 Score = 44.3 bits (103), Expect = 2e-04 Identities = 47/184 (25%), Positives = 87/184 (47%), Gaps = 32/184 (17%) Query: 27 KQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQ 86 KQ+ Q+ + +L +++E +R A+ + Q RL+ E++ L++ L Sbjct: 866 KQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQAL--- 922 Query: 87 YAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQA 146 Q S E D + R KE L + ++ LEQ ++ +R++ L+ E+++++ Sbjct: 923 ------QASQAERDTA--RLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSR- 973 Query: 147 IERNAFLESELDEK----ESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSAPSSPTLD 202 LE+ELDE+ E L V R +D+ LR EL ++ER + L+ Sbjct: 974 ------LETELDEEKNTVELLTDRVNRGRDQVDQLRTEL-MQERS---------ARQDLE 1017 Query: 203 CEKM 206 C+K+ Sbjct: 1018 CDKI 1021 Score = 42.7 bits (99), Expect = 5e-04 Identities = 47/188 (25%), Positives = 85/188 (45%), Gaps = 26/188 (13%) Query: 11 SLKEETAYWKELSLKYKQSFQEARDELVEF--QEGSRELEAELEAQLVQAEQRNRDLQAD 68 +LKEE A +RD+ VE Q+ R+ E +L + A Q + L+A+ Sbjct: 503 ALKEEVA---------------SRDQEVEHVRQQYQRDTE-QLRRSMQDATQDHAVLEAE 546 Query: 69 NQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERA 128 Q++ V L+ +LE ++ S+ + + RA K++L + E E+ ++L Sbjct: 547 RQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGE- 605 Query: 129 KRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKD-EARDLRQELAVRERQ 187 +E ++ L QA K+ LL + + LK+ +A QE+A R R Sbjct: 606 ------KIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRD 659 Query: 188 QEVTRKSA 195 +E+ ++ A Sbjct: 660 RELEKQLA 667 Score = 42.7 bits (99), Expect = 5e-04 Identities = 50/204 (24%), Positives = 89/204 (43%), Gaps = 28/204 (13%) Query: 20 KELSLKYKQSFQEARDELVEFQEGSRELEAE---LEAQLVQAEQRNRDLQADNQRLKYEV 76 +E +L+ +++ Q+ R + E + EAE L + E R+ Q +N + + Sbjct: 680 EEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRI 739 Query: 77 EALKEKLEHQYAQSYKQVSV---LEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATI 133 L+++L+ +V L D L + A K+QL + + ++ L AKRA Sbjct: 740 LGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALE 799 Query: 134 VSLEDF----------EQRLNQAIERNAFL-------ESELDEKESLL-VSVQRLKDE-- 173 LE+ +Q LN+A+E ++EL+E++ LL +V RL E Sbjct: 800 ARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELE 859 Query: 174 --ARDLRQELAVRERQQEVTRKSA 195 D +Q L + Q E ++ A Sbjct: 860 KIGEDSKQALQQLQAQLEDYKEKA 883 Score = 37.4 bits (85), Expect = 0.020 Identities = 38/179 (21%), Positives = 82/179 (45%), Gaps = 29/179 (16%) Query: 14 EETAYWKELSLKYKQSFQEARDELVEFQ---EGSRELEAELEAQLVQAEQRNRDLQA--- 67 EE + +EL + K Q++ EL + + +L LE Q+++ + + + +Q Sbjct: 401 EECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEP 460 Query: 68 ----------DNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRE 117 + + L EV K+++E Q ++++ L+ L + A ++Q ++VR+ Sbjct: 461 AKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQ 520 Query: 118 LEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARD 176 Q D E+ +R+ + A + +A LE+E + +L+ +QR +E + Sbjct: 521 --QYQRDTEQLRRS-----------MQDATQDHAVLEAERQKMSALVRGLQRELEETSE 566 Score = 37.0 bits (84), Expect = 0.026 Identities = 51/206 (24%), Positives = 92/206 (44%), Gaps = 41/206 (19%) Query: 33 ARDELVEF--QEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEH----- 85 +RD+ VE Q+ R+ E +L + A Q + L+A+ Q++ V L+ +LE Sbjct: 510 SRDQEVEHVRQQYQRDTE-QLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEET 568 Query: 86 -----QYAQSYKQVSVLEDDLSQTRAIKEQLHKYV--------RELEQANDDLERAKRAT 132 + ++ + + + +L Q R KE++ + + RELEQA RA Sbjct: 569 GHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQA-----RASAGD 623 Query: 133 IVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAV----RERQQ 188 +E ++ L + E L++E +E R +D R+L ++LAV +R + Sbjct: 624 TRQVEVLKKELLRTQEELKELQAERQSQE----VAGRHRD--RELEKQLAVLRVEADRGR 677 Query: 189 EVTRKSAPSSPTL-----DCEKMDSA 209 E+ ++ TL DCE+ A Sbjct: 678 ELEEQNLQLQKTLQQLRQDCEEASKA 703 Score = 37.0 bits (84), Expect = 0.026 Identities = 46/188 (24%), Positives = 86/188 (45%), Gaps = 16/188 (8%) Query: 41 QEGSRELEAELEAQLVQ-----AEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVS 95 + + L+ EL AQ +Q AE + R Q D R +E +LE + + V Sbjct: 928 ERDTARLDKELLAQRLQGLEQEAENKKRS-QDDRARQLKGLEEKVSRLETELDEEKNTVE 986 Query: 96 VLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRL--NQAIERNAFL 153 +L D +++ R +QL + + A DLE K + +D + RL ++ ++ + Sbjct: 987 LLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSAS 1046 Query: 154 ESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSAPSSPTLDCEKM---DSAV 210 S+L+ + LL +RL+ E R++ ++ +++ RK S ++ E+ D Sbjct: 1047 LSQLESQNQLL--QERLQAEE---REKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKD 1101 Query: 211 QASLSLPA 218 Q SL + A Sbjct: 1102 QLSLRVKA 1109 Score = 33.1 bits (74), Expect = 0.37 Identities = 46/180 (25%), Positives = 77/180 (42%), Gaps = 39/180 (21%) Query: 41 QEGSRELEAELEAQ----------LVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQS 90 +EGS E E + + LV + A L +VE L+ KL+ + + Sbjct: 323 REGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKR 382 Query: 91 YK----QVSV---LEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRL 143 K QV + LE+ + ++E L + E +Q+N +L+ KR L Sbjct: 383 QKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRL-----------L 431 Query: 144 NQAIERNAFLESELDEKESLLVSVQ--------RLKD--EARDLRQE-LAVRERQQEVTR 192 +Q + LE+++ E ++ L VQ LKD E R+L +E L ++R +E R Sbjct: 432 DQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLR 491 >gi|157743265 caspase recruitment domain family, member 11 [Homo sapiens] Length = 1154 Score = 55.1 bits (131), Expect = 9e-08 Identities = 51/196 (26%), Positives = 101/196 (51%), Gaps = 14/196 (7%) Query: 15 ETAYWKELSLKYKQSFQEARDELVEFQEGSRELE---AELEAQLVQAEQRNRDLQADNQR 71 E ++E K K+ DELV+ ++ + L A+L + A R+RDLQ + + Sbjct: 172 ELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQ 231 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRE---LEQANDDLERA 128 LK+ + ++E+ + + QS K L++D+ + R KEQ+ + RE L+ N +L+ Sbjct: 232 LKHRLNKMEEECKLERNQSLK----LKNDI-ENRPKKEQVLELERENEMLKTKNQELQSI 286 Query: 129 KRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQ 188 +A SL D ++ + +E + + L++++ L+ + L++EAR +EL + ++ Sbjct: 287 IQAGKRSLPDSDKAILDILEHDR--KEALEDRQELVNRIYNLQEEARQ-AEELRDKYLEE 343 Query: 189 EVTRKSAPSSPTLDCE 204 + + S+ DCE Sbjct: 344 KEDLELKCSTLGKDCE 359 Score = 38.5 bits (88), Expect = 0.009 Identities = 33/124 (26%), Positives = 61/124 (49%), Gaps = 9/124 (7%) Query: 31 QEARDELVEFQEGSRELEAELEAQLVQAEQ---RNRDLQADNQRLKYEVEALK---EKLE 84 QE + + QE +R+ E + L + E + L D + K+ + + E++E Sbjct: 317 QELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVE 376 Query: 85 HQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDD--LERAKR-ATIVSLEDFEQ 141 + Q++ + SQ K++ K +RELE+ ND+ +E +R A IV+LE + Sbjct: 377 RERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLR 436 Query: 142 RLNQ 145 RL++ Sbjct: 437 RLSK 440 Score = 35.4 bits (80), Expect = 0.075 Identities = 42/194 (21%), Positives = 81/194 (41%), Gaps = 23/194 (11%) Query: 10 SSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADN 69 + ++EE + SLK K + + E ELE E E + ++ +QA Sbjct: 237 NKMEEECKLERNQSLKLKNDIENRPKK-----EQVLELERENEMLKTKNQELQSIIQAGK 291 Query: 70 QRLKYEVEALKEKLEHQYAQSYKQVSVLEDDL----SQTRAIKEQLHKYVRELEQ----- 120 + L +A+ + LEH ++ + L + + + R +E KY+ E E Sbjct: 292 RSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKC 351 Query: 121 --ANDDLERAK---RATIVSLEDFEQRLNQAIERNAFLESE----LDEKESLLVSVQRLK 171 D E K ++ LE+ E+ +QA +++ L EK+ ++ L+ Sbjct: 352 STLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELE 411 Query: 172 DEARDLRQELAVRE 185 ++ ++R E+ RE Sbjct: 412 EKNDEMRIEMVRRE 425 >gi|22208850 Golgi coiled-coil protein 1 [Homo sapiens] Length = 775 Score = 54.3 bits (129), Expect = 2e-07 Identities = 57/226 (25%), Positives = 107/226 (47%), Gaps = 36/226 (15%) Query: 12 LKEETAYWKELSLKYKQSFQE------ARDELVEFQEGSRELEAELEA-----QLVQAEQ 60 L+EE ++L L+ +++ + A +++ F+ +++L E+E Q ++ E+ Sbjct: 254 LQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEK 313 Query: 61 RNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQ----LHKYVR 116 D + Q L+ E LK + Q Q ++ ++ ED L Q ++EQ L + Sbjct: 314 NQPDPRL--QELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQIS 371 Query: 117 ELEQANDDLERAKRATIVSLEDFEQRL------NQAIERNAFLESELD---EKESLLVSV 167 E+ + E+AK+ ++++ ++R+ N+ + A S LD E+ SL V+V Sbjct: 372 EVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNV 431 Query: 168 QRLKDEARDLRQELAVRERQQEVT--------RKSAPSSPTLDCEK 205 LKD+ L++ L V R+ +VT + PSS D EK Sbjct: 432 --LKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEK 475 >gi|169217489 PREDICTED: similar to phosphodiesterase 4D interacting protein [Homo sapiens] Length = 211 Score = 53.1 bits (126), Expect = 3e-07 Identities = 45/154 (29%), Positives = 81/154 (52%), Gaps = 14/154 (9%) Query: 64 DLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDD---LSQTRAIKEQLHKYVRELEQ 120 +L+ Q+L+ E++ ++L A+ Y ++ E + L+ + + KEQL + REL Q Sbjct: 3 ELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 62 Query: 121 ANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQ- 179 D+ ++ A + LE QR+ ++ LE +DEK S L+++ ++LRQ Sbjct: 63 YRDNSDKTLEANEMLLEKLRQRIR---DKAVALERAIDEKFS------ALEEKEKELRQL 113 Query: 180 ELAVRERQQEVTR-KSAPSSPTLDCEKMDSAVQA 212 LAVRER ++ R + SS + M+S ++A Sbjct: 114 RLAVRERDHDLERLRDVLSSNEATMQTMESLLRA 147 >gi|34878904 synaptonemal complex protein 1 [Homo sapiens] Length = 976 Score = 53.1 bits (126), Expect = 3e-07 Identities = 52/192 (27%), Positives = 93/192 (48%), Gaps = 25/192 (13%) Query: 14 EETAYWKELSLKYKQSFQEARD---ELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQ 70 E T++ +LSL+ K+ QE D EL QE + + E L Q E +LQ Sbjct: 515 ELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIE----NLQETET 570 Query: 71 RLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKR 130 +L+ E+E ++E+L+ + + ++ E++ + R E +KY+ EL+Q N L++ Sbjct: 571 QLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGT 630 Query: 131 ATIVSLEDFEQRLNQAI-----------ERNAFLESELDEK----ESLLVSVQRLK---D 172 A L +E ++N+ E + E+++K E+LL V++ K D Sbjct: 631 AESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIAD 690 Query: 173 EARDLRQELAVR 184 EA L++E+ R Sbjct: 691 EAVKLQKEIDKR 702 Score = 45.8 bits (107), Expect = 6e-05 Identities = 41/172 (23%), Positives = 78/172 (45%), Gaps = 10/172 (5%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 LKE A E + KY+ +E R ++ ++ E VQAE ++ + Sbjct: 186 LKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKE 245 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRA 131 +++ L+++ + + KQVS+L L Q + ++ LE++ D + + + Sbjct: 246 DYEKIQHLEQEYKKEINDKEKQVSLL---LIQITEKENKMKDLTFLLEESRDKVNQLEEK 302 Query: 132 TIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAV 183 T + E+ L Q+IE+ L EL E + VS+QR + L ++L + Sbjct: 303 TKLQSEN----LKQSIEKQHHLTKEL---EDIKVSLQRSVSTQKALEEDLQI 347 Score = 42.0 bits (97), Expect = 8e-04 Identities = 47/233 (20%), Positives = 101/233 (43%), Gaps = 27/233 (11%) Query: 2 DGEDIPDFSSLKEETAYWKELSLKYKQSFQEA-RDELVEFQEGSRELEAELEAQLVQAEQ 60 + E I + E KE L+ + EA R + E Q G+ ++ +LE + Q Sbjct: 112 EAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGI----Q 167 Query: 61 RNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQ 120 N+DL +N ++ LKE A+S ++ E + +TR + L+ + ++ Sbjct: 168 ENKDLIKENNATRHLCNLLKETC----ARSAEKTKKYEYEREETRQVYMDLNNNIEKMIT 223 Query: 121 ANDDLERAKRATIVSL---------------EDFEQRLNQAIERNAFLESELDEKESLLV 165 A ++L + + + +++++ +N ++ + L ++ EKE+ + Sbjct: 224 AFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMK 283 Query: 166 SVQRLKDEARDLRQELAVRERQQEVTRKSAPSSP---TLDCEKMDSAVQASLS 215 + L +E+RD +L + + Q K + T + E + ++Q S+S Sbjct: 284 DLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVS 336 Score = 36.2 bits (82), Expect = 0.044 Identities = 43/207 (20%), Positives = 90/207 (43%), Gaps = 42/207 (20%) Query: 21 ELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQA---EQRNRDL-----------Q 66 E+ K K+ +++ + E+++ + E ++ L+Q E + +DL Sbjct: 238 EMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVN 297 Query: 67 ADNQRLKYEVEALKEKLE--HQYAQSYKQVSV-LEDDLSQTRAIKEQLHKYVREL----E 119 ++ K + E LK+ +E H + + + V L+ +S +A++E L + + E Sbjct: 298 QLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTE 357 Query: 120 QANDDLERAKRA-------------TIVSLEDFEQRLNQAIERN----AFLESELDEKES 162 + +E + +A T+ SLE+ + Q +E+N L EL +K S Sbjct: 358 EKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSS 417 Query: 163 LLVSVQRLKD----EARDLRQELAVRE 185 L + +L + E +L++ L +E Sbjct: 418 ELEEMTKLTNNKEVELEELKKVLGEKE 444 >gi|32698688 citron [Homo sapiens] Length = 2027 Score = 52.4 bits (124), Expect = 6e-07 Identities = 45/167 (26%), Positives = 81/167 (48%), Gaps = 23/167 (13%) Query: 34 RDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEAL---KEKLEHQYAQS 90 ++ L+E + RE+ E E Q ++ +++ +LQ Q + ++ AL + LE Q Q+ Sbjct: 848 KNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQA 907 Query: 91 YKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLER---AKRATIVSLEDFEQRLNQAI 147 + +L +T A E+ ++ L D+++R A R + + D E++LNQ Sbjct: 908 -------KTELEETTAEAEE---EIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLT 957 Query: 148 ERNA-------FLESELDEKESLLVSVQRLKDEARDLRQELAVRERQ 187 E NA +L +LDE + +L+ E LR+E+ RE Q Sbjct: 958 EDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQ 1004 Score = 31.2 bits (69), Expect = 1.4 Identities = 34/127 (26%), Positives = 57/127 (44%), Gaps = 13/127 (10%) Query: 75 EVEALKEKLEHQYAQSYKQVSVLEDDL----SQTRAIKEQLHKYVRELEQANDD----LE 126 EVEA+ + E + S Q S+LE DL ++ ++K L + E+ Q +D L Sbjct: 481 EVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLH 540 Query: 127 RAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKD--EARDLRQELAVR 184 + + E EQ +E + ++L+E LVS +R D E+ LA Sbjct: 541 DIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEED---LVSARRRSDLYESELRESRLAAE 597 Query: 185 ERQQEVT 191 E +++ T Sbjct: 598 EFKRKAT 604 >gi|148746195 trichohyalin [Homo sapiens] Length = 1943 Score = 52.0 bits (123), Expect = 8e-07 Identities = 46/193 (23%), Positives = 90/193 (46%), Gaps = 7/193 (3%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 L+ E +E LK ++ + + L Q+ RE E E L + E++ + + QR Sbjct: 507 LRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQR 566 Query: 72 LKYEVEALKEKL-EHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYV----RELEQANDDLE 126 LK E E +++L + + + +++ +++ + R +E++ + RE ++ E Sbjct: 567 LKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPE 626 Query: 127 RAKRATIVSLEDFEQRLNQAI--ERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVR 184 +R ++ E+ E+R Q + E+ E L +E QRLK E + R+E + Sbjct: 627 EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELA 686 Query: 185 ERQQEVTRKSAPS 197 E +QE R+ S Sbjct: 687 EEEQEQARERIKS 699 Score = 47.4 bits (111), Expect = 2e-05 Identities = 51/192 (26%), Positives = 83/192 (43%), Gaps = 21/192 (10%) Query: 4 EDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVE--FQEGSRELEAELEAQLVQAEQR 61 E+ PD L+ EL K ++ Q+ R E + FQE + + E L + E++ Sbjct: 202 EEFPDEEQLRRRELL--ELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK 259 Query: 62 NRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQA 121 ++ + QR E E KLE Q + +Q E++ Q R +EQ + +E E+ Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQ----EEEQQQQRLRREQQLRRKQEEERR 315 Query: 122 NDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQEL 181 ER E E+R Q R L E +E+ Q+L+ E + R+E Sbjct: 316 EQQEERR--------EQQERREQQEERREQQLRREQEERRE-----QQLRREQEEERREQ 362 Query: 182 AVRERQQEVTRK 193 +R Q+E R+ Sbjct: 363 QLRREQEEERRE 374 Score = 47.0 bits (110), Expect = 3e-05 Identities = 50/178 (28%), Positives = 81/178 (45%), Gaps = 9/178 (5%) Query: 13 KEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEA-ELEAQLVQAEQRNRDLQADNQR 71 K ET KE ++ Q R EL E +E R+LE EL + + EQ+ + L+ + Q Sbjct: 248 KRETVLRKEEEKLQEEEPQRQR-ELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL 306 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRA 131 + + E +E+ E + Q ++ E Q R +E+ R +Q + E +R Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQEE-----RREQQLRREQEEERRE 361 Query: 132 TIVSLEDFEQRLNQAIERNAFLESELD-EKESLLVSVQRLKDEARDLRQELAVRERQQ 188 + E E+R Q + R L E +E L Q+L+ E + LR+E +R QQ Sbjct: 362 QQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE-QQLRREQQLRREQQ 418 Score = 46.2 bits (108), Expect = 4e-05 Identities = 42/177 (23%), Positives = 78/177 (44%), Gaps = 16/177 (9%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 L+ E +E L+ +Q + + +L Q+ RE + E QL + +Q R+ + + Sbjct: 377 LRREQQLRREQQLRREQQLRREQ-QLRREQQLRREQQLRREQQLRREQQLRREQEEERHE 435 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRA 131 K+E E +++L+ + + + R + + H+ R +Q D E +R Sbjct: 436 QKHEQERREQRLKREQEERRDWLK---------REEETERHEQERRKQQLKRDQEEERRE 486 Query: 132 TIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQ 188 + LE+ E+R Q R L E +E+ QRLK + + R + +R QQ Sbjct: 487 RWLKLEE-EERREQQERREQQLRREQEERRE-----QRLKRQEEEERLQQRLRSEQQ 537 Score = 45.1 bits (105), Expect = 1e-04 Identities = 42/185 (22%), Positives = 89/185 (48%), Gaps = 18/185 (9%) Query: 20 KELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNR----DLQADNQRLK-- 73 KEL ++ + R+ + QE L+ + E + Q ++R++ L+ + +R + Sbjct: 829 KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHT 888 Query: 74 -YEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRAT 132 Y AL+E+L + ++ L+ + + R +EQ +Y RE EQ + E+ R Sbjct: 889 LYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY-REEEQLQQEEEQLLR-- 945 Query: 133 IVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQ----RLKDEARDLRQELAVRERQQ 188 E+ E+R Q ER + +L +KE L+ + R ++ + R+E +++ ++ Sbjct: 946 ----EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001 Query: 189 EVTRK 193 ++ R+ Sbjct: 1002 QLLRE 1006 Score = 42.4 bits (98), Expect = 6e-04 Identities = 48/205 (23%), Positives = 92/205 (44%), Gaps = 34/205 (16%) Query: 13 KEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQA----- 67 +EE +E L ++ + R E EL+ E E QL++ E+ R LQ Sbjct: 992 EEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE-EEQLLREEREKRRLQERERQY 1050 Query: 68 -DNQRLKYEVEAL---------KEKLEHQYA-----QSYKQVSVLEDDLSQTRAIKEQLH 112 + + L+ E E L +++LE QY Q ++ + E+ + R +E+ Sbjct: 1051 REEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQC 1110 Query: 113 KYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLV----SVQ 168 + EL+Q + L R +R E+R Q +ER E E+ ++E L+ + Sbjct: 1111 REEEELQQEEEQLLREER---------EKRRRQELERQYREEEEVQQEEEQLLREEPEKR 1161 Query: 169 RLKDEARDLRQELAVRERQQEVTRK 193 R ++ R R+E +++ ++++ R+ Sbjct: 1162 RRQELERQYREEEELQQEEEQLLRE 1186 Score = 40.4 bits (93), Expect = 0.002 Identities = 45/186 (24%), Positives = 86/186 (46%), Gaps = 14/186 (7%) Query: 13 KEETAYWKELSLKYK---QSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADN 69 +E+ +EL K++ Q QE E + QE R++ LE + ++ E+ + L+ Sbjct: 1712 EEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKI---LEEEQLRPEREEQQLRRQE 1768 Query: 70 QRLKY-EVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERA 128 + K+ E E L+++ E Q +S + ++ Q R +E+ ++L D + Sbjct: 1769 RDRKFREEEQLRQEREEQQLRSQESDRKFREE-EQLRQEREE-----QQLRPQQRDGKYR 1822 Query: 129 KRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRL-KDEARDLRQELAVRERQ 187 + LE+ EQRL Q +R E + +E Q L ++E + RQE + R+ Sbjct: 1823 WEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLRE 1882 Query: 188 QEVTRK 193 + + R+ Sbjct: 1883 EHIRRQ 1888 Score = 37.4 bits (85), Expect = 0.020 Identities = 35/180 (19%), Positives = 75/180 (41%), Gaps = 7/180 (3%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 L+ E +E L+ +Q + +L QE R E QL + +Q R+ Q ++ Sbjct: 339 LRREQEERREQQLRREQEEERREQQLRREQEEERR-----EQQLRREQQLRREQQLRREQ 393 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAK-- 129 + L+ + + + Q ++ L + R +E+ H+ E E+ L+R + Sbjct: 394 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE 453 Query: 130 RATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQE 189 R + E+ +R Q + + +E+ + ++ + + R+E +R Q+E Sbjct: 454 RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE 513 Score = 37.0 bits (84), Expect = 0.026 Identities = 55/200 (27%), Positives = 91/200 (45%), Gaps = 24/200 (12%) Query: 4 EDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAE-LEAQLVQAEQRN 62 E+ D+ +EET E + ++ Q RD+ E +E +LE E Q + EQ+ Sbjct: 452 EERRDWLKREEET----ERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL 507 Query: 63 RDLQAD--NQRLK--YEVEALKEKLEHQY----AQSYKQVSVLEDDLSQTRAIKEQLHKY 114 R Q + QRLK E E L+++L + Q ++ +L+ + + + + + Sbjct: 508 RREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRL 567 Query: 115 VRELEQANDDL---ERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLK 171 RE E+ D L E +R + E E+RL Q ++R E +E+ QRLK Sbjct: 568 KREQEERRDQLLKREEERRQQRLKREQ-EERLEQRLKREEVERLEQEERRE-----QRLK 621 Query: 172 DE--ARDLRQELAVRERQQE 189 E + RQ+L E Q+E Sbjct: 622 REEPEEERRQQLLKSEEQEE 641 Score = 36.6 bits (83), Expect = 0.034 Identities = 49/203 (24%), Positives = 90/203 (44%), Gaps = 15/203 (7%) Query: 13 KEETAYWKELSLKYK---QSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADN 69 +EE +E K++ Q QE ++ + QE R+ E +L EQ + L+ + Sbjct: 1325 REEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREE---ELRHQEQGRKFLEEEQ 1381 Query: 70 QRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAK 129 + + E E K E Q ++ + +D + R ++QL + R+ + ++ + + Sbjct: 1382 RLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441 Query: 130 RATIVSLEDFEQRLNQAIERNAFLESE--LDEKESLLVSVQR-----LKDEARDLRQELA 182 + + EQ+L Q R F E E L E+E + Q L++E + RQE Sbjct: 1442 QERERKFLEEEQQLRQERHRK-FREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERD 1500 Query: 183 VRERQQEVTRKSAPSSPTLDCEK 205 + R+QE+ R P L+ E+ Sbjct: 1501 RKFREQEL-RSQEPERKFLEEEQ 1522 Score = 36.2 bits (82), Expect = 0.044 Identities = 43/193 (22%), Positives = 82/193 (42%), Gaps = 31/193 (16%) Query: 27 KQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEV---------- 76 +Q QE ++ + QE R+ LE Q V+ +++ R D Q+L+ + Sbjct: 1561 EQLRQEREEQQLSRQERDRKFR--LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD 1618 Query: 77 -------EALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVR--------ELEQA 121 + L+E+ E Q + + LE++ R +EQ ++ R +L Q Sbjct: 1619 RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678 Query: 122 NDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQEL 181 ++ + ++ + EQ+L + FL+ +E++ ++R E LRQE Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQ---EEQQLRRQELERKFREEEQLRQET 1735 Query: 182 AVRE-RQQEVTRK 193 + R+QE RK Sbjct: 1736 EQEQLRRQERYRK 1748 Score = 35.4 bits (80), Expect = 0.075 Identities = 48/195 (24%), Positives = 79/195 (40%), Gaps = 35/195 (17%) Query: 28 QSFQEARDELVEFQEGSRELEAELEA----QLVQAEQRNR-----------DLQADNQRL 72 Q QE D L E QE R E + QL + +R R L+ + Q L Sbjct: 847 QQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL 906 Query: 73 KYEVEAL------KEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLE 126 + E E L K + + Q Q ++ + +++ R +E+ + RE + D Sbjct: 907 QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL 966 Query: 127 RAKRATIVSLEDFEQRLNQAIERNAFLESELD-EKESLLVSVQ------------RLKDE 173 + K ++ E+ E+R Q E+ E EL E+E LL + R KDE Sbjct: 967 QQKEEQLLG-EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDE 1025 Query: 174 ARDLRQELAVRERQQ 188 + ++L ER++ Sbjct: 1026 LQQEEEQLLREEREK 1040 Score = 35.4 bits (80), Expect = 0.075 Identities = 45/209 (21%), Positives = 85/209 (40%), Gaps = 41/209 (19%) Query: 13 KEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNR--------- 63 +EE +E L ++ + R EL EL+ E E QL++ EQ R Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE-EEQLLREEQEKRRQERERQYR 1200 Query: 64 ---DLQADNQRLKYEVEALKEKLEHQY----------------AQSYKQVSVLEDDLSQT 104 +LQ ++ +Y E + L+ Q+ + +Q LED + Sbjct: 1201 EEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRD 1260 Query: 105 RAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLL 164 R ++ L + E ++ + + ER + ++QR E + E +E++ Sbjct: 1261 RQSQQDLQHLLGEQQERDREQERRR---------WQQRDRHFPEEE---QLEREEQKEAK 1308 Query: 165 VSVQRLKDEARDLRQELAVRERQQEVTRK 193 ++ ++E + LR+E + R+QE RK Sbjct: 1309 RRDRKSQEEKQLLREEREEKRRRQETDRK 1337 Score = 35.0 bits (79), Expect = 0.098 Identities = 40/169 (23%), Positives = 81/169 (47%), Gaps = 14/169 (8%) Query: 27 KQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQ 86 +Q ++ RD +F+E + L+ E QL + E+ + L+ + Q + E E ++L H Sbjct: 1610 QQQLRQERDR--KFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQERE---QQLRHD 1664 Query: 87 YAQSYKQVSVLEDDLSQTRAIKEQLHKYVRE--LEQANDDLERAKRATIVSLEDFEQRLN 144 + +++ E+ L Q ++QL + R+ + L R +R L++ +Q Sbjct: 1665 RDRKFRE----EEQLLQ-EGEEQQLRRQERDRKFREEEQQLRRQERER-KFLQEEQQLRR 1718 Query: 145 QAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRK 193 Q +ER F E E +E+ ++R + + L +E ER+++ R+ Sbjct: 1719 QELERK-FREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRR 1766 Score = 34.7 bits (78), Expect = 0.13 Identities = 41/177 (23%), Positives = 81/177 (45%), Gaps = 14/177 (7%) Query: 27 KQSFQEARDELVEFQEGSREL-EAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEH 85 +Q ++ RD +F+E ++L E E + +Q EQ+ R + + ++ + E + +E + Sbjct: 1682 QQLRRQERDR--KFREEEQQLRRQERERKFLQEEQQLRRQELE-RKFREEEQLRQETEQE 1738 Query: 86 QYAQSYKQVSVLEDDLSQTRAIKEQLHKY-----VRELEQANDDLERAKRATIVSLEDF- 139 Q + + +LE++ + ++QL + RE EQ + E + + S F Sbjct: 1739 QLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFR 1798 Query: 140 -EQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSA 195 E++L Q E + D K +L+++ + LRQE R+RQ + A Sbjct: 1799 EEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQE---RDRQYRAEEQFA 1852 Score = 34.3 bits (77), Expect = 0.17 Identities = 38/191 (19%), Positives = 86/191 (45%), Gaps = 20/191 (10%) Query: 20 KELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVE-- 77 +EL + +Q +E +++ + +E E EL+ Q + R+ D ++D LK++ E Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSD---LKWQWEPE 1230 Query: 78 ---ALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAK----- 129 A+++ + + +Q LED + R ++ L + E ++ + + ER + Sbjct: 1231 KENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRD 1290 Query: 130 -------RATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELA 182 + ++ ++R ++ E L E +EK + ++ ++E + L++ Sbjct: 1291 RHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE 1350 Query: 183 VRERQQEVTRK 193 R+QE RK Sbjct: 1351 QPLRRQERDRK 1361 Score = 30.8 bits (68), Expect = 1.9 Identities = 45/189 (23%), Positives = 83/189 (43%), Gaps = 18/189 (9%) Query: 13 KEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRL 72 KEE +E L ++ + R E EL+ E E QL++ E+ R Q ++ Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQE-EEQLLREEREKRRRQELERQY 1140 Query: 73 KYEVEA-------LKEKLEHQYAQSYKQVSVLEDDLSQ--TRAIKEQLHKYVRELE---Q 120 + E E L+E+ E + Q ++ E++L Q + ++E+ K +E E + Sbjct: 1141 REEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYR 1200 Query: 121 ANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQE 180 ++L+R KR ED L E E E +++ + R ++ R L ++ Sbjct: 1201 EEEELQRQKRKQRYRDEDQRSDLKWQWEP----EKENAVRDNKVYCKGRENEQFRQL-ED 1255 Query: 181 LAVRERQQE 189 +R+RQ + Sbjct: 1256 SQLRDRQSQ 1264 >gi|119120918 coiled-coil domain containing 64 [Homo sapiens] Length = 573 Score = 51.6 bits (122), Expect = 1e-06 Identities = 43/174 (24%), Positives = 84/174 (48%), Gaps = 23/174 (13%) Query: 20 KELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEAL 79 +++S +Y+Q +E D+L ++ EL E + + E R +L++D V+ L Sbjct: 125 QDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESD-------VKQL 177 Query: 80 KEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQAN--DDLERAKRATIVSL- 136 +++LE Q Q+ + E D ++RA++E + R L+Q + ++ER + +L Sbjct: 178 QDELERQ------QIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALR 231 Query: 137 EDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEV 190 EDF E+N+ + ESL ++ L D R+L L+ + ++ Sbjct: 232 EDFR-------EKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDL 278 Score = 38.1 bits (87), Expect = 0.012 Identities = 45/208 (21%), Positives = 90/208 (43%), Gaps = 20/208 (9%) Query: 21 ELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRD-------LQADNQRLK 73 EL +++ E + E + ++L+ ELE Q + + +R+ L NQRL Sbjct: 151 ELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLL 210 Query: 74 YEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQ-------LHKYVRELEQANDDLE 126 ++ E +E Q + QV L +D + + Q L ++ L +LE Sbjct: 211 DQLSRASE-VERQLSM---QVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELE 266 Query: 127 RAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEAR-DLRQ-ELAVR 184 AT+ + + + + +R LE + +K+ L Q E R RQ ++ V Sbjct: 267 HRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVE 326 Query: 185 ERQQEVTRKSAPSSPTLDCEKMDSAVQA 212 E +E + +S+ ++ T +++ +++A Sbjct: 327 ELTEERSLQSSAATSTSLLSEIEQSMEA 354 >gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] Length = 1960 Score = 51.2 bits (121), Expect = 1e-06 Identities = 40/160 (25%), Positives = 85/160 (53%), Gaps = 6/160 (3%) Query: 31 QEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQS 90 +E R L ++ E+ +LEA++ + E+R + LQA+ ++++ ++ L+E+LE + +S Sbjct: 900 EELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE--ES 957 Query: 91 YKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERN 150 +Q LE ++ + K + + + LE N L + K+ + +F L + E++ Sbjct: 958 ARQKLQLEKVTTEAKLKKLEEEQII--LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKS 1015 Query: 151 AFLESELDEKESLLVSV-QRLKDEARDLRQELAVRERQQE 189 L ++ E+++ + +RL+ E + RQEL R+ E Sbjct: 1016 KSLAKLKNKHEAMITDLEERLRREEKQ-RQELEKTRRKLE 1054 Score = 46.6 bits (109), Expect = 3e-05 Identities = 43/170 (25%), Positives = 79/170 (46%), Gaps = 14/170 (8%) Query: 27 KQSFQEARDELVEFQEGSRELEAELEAQLVQAEQ--RNRDLQADNQR--LKYEVEALKEK 82 K +E DEL ++ LE L+A Q E+ + RD Q++ ++ L +V ++ + Sbjct: 1538 KTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAE 1597 Query: 83 LEHQYAQSYKQVSV---LEDDLSQTRAI-------KEQLHKYVRELEQANDDLERAKRAT 132 LE + Q V+ LE DL A +++ K +R+L+ D R T Sbjct: 1598 LEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDT 1657 Query: 133 IVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELA 182 S E+ + + ++ +E+E+ + + L + +R K +A+ R ELA Sbjct: 1658 RASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELA 1707 Score = 44.3 bits (103), Expect = 2e-04 Identities = 47/206 (22%), Positives = 94/206 (45%), Gaps = 11/206 (5%) Query: 25 KYKQSFQEARDEL----VEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALK 80 K +Q ++ R +L + + EL+A++ +Q ++ +LQA R++ E A K Sbjct: 1041 KQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEA-AQK 1099 Query: 81 EKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVS-LEDF 139 + + Q+S L++DL RA + + K R+L + + L+ T+ S Sbjct: 1100 NMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQ 1159 Query: 140 EQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVR-ERQQEVTRKSAPSS 198 E R + E N ++ +E ++ +Q ++ + +ELA + E+ + V + Sbjct: 1160 ELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAK 1219 Query: 199 PTLDCEKMDSAVQASLSLPATPVGKG 224 TL+ E+ + A + + L GKG Sbjct: 1220 QTLENERGELANEVKVLLQ----GKG 1241 Score = 43.9 bits (102), Expect = 2e-04 Identities = 44/204 (21%), Positives = 90/204 (44%), Gaps = 17/204 (8%) Query: 11 SLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQ 70 +L+EE + + +Q +A +EL E E ++ ++A LE + + L+ + Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLE-------KAKQTLENERG 1227 Query: 71 RLKYEVEAL---KEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDD--- 124 L EV+ L K EH+ + Q+ L+ ++ ++ +L V +L+ D+ Sbjct: 1228 ELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTG 1287 Query: 125 -LERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAV 183 L ++ + +DF +Q + L+ E +K SL +++++DE R++L Sbjct: 1288 LLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQL-- 1345 Query: 184 RERQQEVTRKSAPSSPTLDCEKMD 207 E ++E TL + D Sbjct: 1346 -EEEEEAKHNLEKQIATLHAQVAD 1368 Score = 41.2 bits (95), Expect = 0.001 Identities = 40/164 (24%), Positives = 73/164 (44%), Gaps = 15/164 (9%) Query: 49 AELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIK 108 AE L + E++++ L +LK + EA+ LE + + KQ LE + Sbjct: 1002 AEFTTNLTEEEEKSKSLA----KLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057 Query: 109 EQLHKYVRELEQANDDL-------ERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKE 161 L + EL+ +L E +A + +E+ + N A+++ LES++ E + Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ 1117 Query: 162 SLLVSVQRLKDEA----RDLRQELAVRERQQEVTRKSAPSSPTL 201 L S + +++A RDL +EL + + E T S + L Sbjct: 1118 EDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQEL 1161 Score = 40.4 bits (93), Expect = 0.002 Identities = 48/181 (26%), Positives = 86/181 (47%), Gaps = 27/181 (14%) Query: 27 KQSFQEARDELVEFQEGSRELEAE---LEAQLVQAEQRNRDLQADNQRLKYEVE------ 77 + S +E + E ++ + +EAE L+ +L AE+ R Q + L E+ Sbjct: 1658 RASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKG 1717 Query: 78 --ALKEK--LEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATI 133 AL+EK LE + AQ ++ LE++ T I ++L K +++Q N DL +R+ Sbjct: 1718 ALALEEKRRLEARIAQLEEE---LEEEQGNTELINDRLKKANLQIDQINTDL-NLERSHA 1773 Query: 134 VSLEDFEQRLNQAIERNAFLESELDEKESLL-----VSVQRLKDEARDLRQEL--AVRER 186 E+ Q+L + +N L+ +L E E + S+ L+ + L ++L +ER Sbjct: 1774 QKNENARQQLER---QNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKER 1830 Query: 187 Q 187 Q Sbjct: 1831 Q 1831 Score = 37.4 bits (85), Expect = 0.020 Identities = 53/233 (22%), Positives = 97/233 (41%), Gaps = 31/233 (13%) Query: 4 EDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQ-----A 58 +D+ S EE + K K Q+ D+L+ + R+ LE + + A Sbjct: 1392 KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLA 1451 Query: 59 EQRNRDLQADNQRLKYEVEALKEK-----LEHQYAQSYKQVSVLE-------DDLSQTRA 106 E++ + +R + E EA +++ L ++ +Q + LE ++ + Sbjct: 1452 EEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMS 1511 Query: 107 IKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVS 166 K+ + K V ELE++ LE+ LE+ E L QA E D K L V+ Sbjct: 1512 SKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL-QATE---------DAKLRLEVN 1561 Query: 167 VQRLKDEARDLRQELAVRERQQEVTRKS-APSSPTLDCEKMDSAVQASLSLPA 218 +Q +K + ++L R+ Q E +K ++ E D Q S+++ A Sbjct: 1562 LQAMKAQ---FERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAA 1611 Score = 37.0 bits (84), Expect = 0.026 Identities = 46/183 (25%), Positives = 86/183 (46%), Gaps = 23/183 (12%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 LK W L K K Q +R E E+ A+ E +LV+ R + L A+N+ Sbjct: 820 LKLRNWQWWRLFTKVKPLLQVSRQE--------EEMMAK-EEELVKV--REKQLAAENRL 868 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLE---RA 128 E+E L+ +L + Q +Q+ + ++ ++ +L +ELE+ DLE Sbjct: 869 T--EMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEE 926 Query: 129 KRATIVSLEDFEQRLNQAIERNAFLESELDEKESL--LVSVQRLKDEA--RDLRQELAVR 184 + L+ ++++ Q I+ LE +L+E+ES + ++++ EA + L +E + Sbjct: 927 EEERCQHLQAEKKKMQQNIQE---LEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIIL 983 Query: 185 ERQ 187 E Q Sbjct: 984 EDQ 986 Score = 33.9 bits (76), Expect = 0.22 Identities = 38/183 (20%), Positives = 82/183 (44%), Gaps = 22/183 (12%) Query: 13 KEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELE---AQLVQAEQRNRDLQADN 69 K+ A +EL +K+ + + R EL + +L+ EL+ L Q++ ++ L D Sbjct: 1248 KKVEAQLQELQVKFNEG-ERVRTELAD---KVTKLQVELDNVTGLLSQSDSKSSKLTKDF 1303 Query: 70 QRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAK 129 L+ +++ +E L+ + Q + L+ + + +EQL E E+A +LE+ Sbjct: 1304 SALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLE----EEEEAKHNLEKQI 1359 Query: 130 RATIVSLEDFEQRLNQAI-------ERNAFLESELD----EKESLLVSVQRLKDEARDLR 178 + D ++++ ++ E L+ +L+ E + + +L+ L+ Sbjct: 1360 ATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQ 1419 Query: 179 QEL 181 QEL Sbjct: 1420 QEL 1422 Score = 29.6 bits (65), Expect = 4.1 Identities = 33/150 (22%), Positives = 67/150 (44%), Gaps = 21/150 (14%) Query: 20 KELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEAL 79 KEL +K ++ + + ++ LEA++ Q + ++ QA ++++ + L Sbjct: 1788 KELKVKLQEMEGTVKSK---YKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKL 1844 Query: 80 KEKL-----EHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIV 134 K+ L E + A+ YK + D + TR L + R+LE+A ++ +RA Sbjct: 1845 KDVLLQVDDERRNAEQYKD----QADKASTR-----LKQLKRQLEEAEEEAQRAN----A 1891 Query: 135 SLEDFEQRLNQAIERNAFLESELDEKESLL 164 S ++ L A E + E+ ++ L Sbjct: 1892 SRRKLQRELEDATETADAMNREVSSLKNKL 1921 >gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] Length = 1417 Score = 51.2 bits (121), Expect = 1e-06 Identities = 41/189 (21%), Positives = 94/189 (49%), Gaps = 10/189 (5%) Query: 20 KELSLKYKQSFQEARDE-------LVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRL 72 +++ ++ +QS QE+++E L+E + + E + L AE+ ++ Q +++ Sbjct: 318 QKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKV 377 Query: 73 KYEVE---ALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAK 129 ++E A +E LE K+ L++ ++ E L + +R+L++ N++ + Sbjct: 378 AEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKL 437 Query: 130 RATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQE 189 R V + +L ++ + LESEL+ K+ +L L +E R+L+ +A + + + Sbjct: 438 RIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLD 497 Query: 190 VTRKSAPSS 198 + ++ SS Sbjct: 498 LCQQEIESS 506 Score = 43.9 bits (102), Expect = 2e-04 Identities = 46/189 (24%), Positives = 89/189 (47%), Gaps = 25/189 (13%) Query: 15 ETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNR---DLQADNQR 71 +T K++S K +Q Q+ R+ E R++E + E+ +A+ + + +L ++ Sbjct: 932 QTKLEKQVS-KLEQELQKQRESSAE---KLRKMEEKCESAAHEADLKRQKVIELTGTARQ 987 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDD-------LSQTRAIKEQLHKYVRELEQANDD 124 +K E++ KE+L ++ K++ L+ D LSQ I +Q + + A + Sbjct: 988 VKIEMDQYKEEL----SKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKE 1043 Query: 125 LERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVR 184 LE+ + +T E L +A+++ LE+EL L S R E RD+ Q+ + Sbjct: 1044 LEKLQHST-------ETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLS 1096 Query: 185 ERQQEVTRK 193 ++ T K Sbjct: 1097 LEEKYTTIK 1105 Score = 40.8 bits (94), Expect = 0.002 Identities = 45/175 (25%), Positives = 78/175 (44%), Gaps = 17/175 (9%) Query: 14 EETAYWKELSLKY-KQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRL 72 E T EL LK + + D+L +E RE E + + Q ++++ QR+ Sbjct: 1168 EGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRM 1227 Query: 73 KYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTR--------AIKEQLHKYV---RELEQA 121 K E+E++ ++ E A YK+ L +L TR + E H+ V RE+E+ Sbjct: 1228 K-EMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERL 1286 Query: 122 NDDLERAKRAT---IVSLEDFEQRLNQAIERNAFLESELD-EKESLLVSVQRLKD 172 + +LE K+ + + L + R A LE+ + E + L V+ LK+ Sbjct: 1287 SSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKE 1341 Score = 38.1 bits (87), Expect = 0.012 Identities = 30/142 (21%), Positives = 64/142 (45%), Gaps = 7/142 (4%) Query: 45 RELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVL---EDDL 101 RE E+E ++++ E + + + ++E+L +KL++ Q ++ ++ E ++ Sbjct: 1154 REHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEI 1213 Query: 102 SQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKE 161 SQ + E+ + ++E+E + E+ D Q L E+ +EL E Sbjct: 1214 SQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEAR 1273 Query: 162 SLLV----SVQRLKDEARDLRQ 179 V ++RL E D++Q Sbjct: 1274 HQQVQAQREIERLSSELEDMKQ 1295 Score = 37.4 bits (85), Expect = 0.020 Identities = 49/202 (24%), Positives = 90/202 (44%), Gaps = 33/202 (16%) Query: 31 QEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEK-------- 82 Q+A+ L E ++L AEL ++ E + ++L +Q LK LK++ Sbjct: 1091 QKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLD 1150 Query: 83 --LEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAK----RATIVSL 136 + + +++ LE L ++ +L + +++E ND L+ AK + L Sbjct: 1151 MTIREHRGEMEQKIIKLEGTLEKSEL---ELKECNKQIESLNDKLQNAKEQLREKEFIML 1207 Query: 137 EDFEQ--RLNQAIERN----AFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEV 190 ++ ++ +L + IER +ES + E+E + + + EA DL QEL + Sbjct: 1208 QNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYK---EAIDLGQEL-------RL 1257 Query: 191 TRKSAPSSPTLDCEKMDSAVQA 212 TR+ +S T E VQA Sbjct: 1258 TREQVQNSHTELAEARHQQVQA 1279 Score = 36.2 bits (82), Expect = 0.044 Identities = 30/152 (19%), Positives = 70/152 (46%), Gaps = 8/152 (5%) Query: 50 ELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKE 109 EL +L+Q E N DL+ + + + ++E+L + + S K S + SQ +++ Sbjct: 645 ELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEK 704 Query: 110 QLHKYV---RELEQANDDLERAKRATIVSLEDFEQRLNQAIER--NAFLESE---LDEKE 161 QL + + + N +LE+ + E +N E+ AF +++ L++ + Sbjct: 705 QLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHK 764 Query: 162 SLLVSVQRLKDEARDLRQELAVRERQQEVTRK 193 + ++RL+ + Q+ +E+ + ++ Sbjct: 765 EMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQ 796 Score = 32.7 bits (73), Expect = 0.49 Identities = 42/177 (23%), Positives = 78/177 (44%), Gaps = 10/177 (5%) Query: 27 KQSFQEARDELVEFQEGSRELEAELEA-QLVQAEQRNRDLQADNQRLKYEVEALKEKLEH 85 K E R +L + ++L A L A QL Q+ D Q ++ E E +K H Sbjct: 556 KLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLG-GH 614 Query: 86 QYAQSYKQVSV------LEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDF 139 Q A+S K + E + + E+L + ++E N DL+ + Sbjct: 615 QVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLI 674 Query: 140 EQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVR--ERQQEVTRKS 194 ++ L + ++ LESE+ +K S L+++++ +E +A + E +QE+ K+ Sbjct: 675 QEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKN 731 Score = 32.7 bits (73), Expect = 0.49 Identities = 38/189 (20%), Positives = 82/189 (43%), Gaps = 15/189 (7%) Query: 10 SSLKEETAYWKELSLKYKQSF---QEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQ 66 S +KE+ Y ++ +YK++ QE R + Q EL AE Q VQA Q Sbjct: 1232 SVMKEQEQY---IATQYKEAIDLGQELRLTREQVQNSHTEL-AEARHQQVQA-------Q 1280 Query: 67 ADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLE 126 + +RL E+E +K+ + + A L + ++ ++ +++L + L+ Sbjct: 1281 REIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLK 1340 Query: 127 RAKRATIVSLEDFEQRLNQAIERNAFLESELDEK-ESLLVSVQRLKDEARDLRQELAVRE 185 A ++S ++ + + + +L+E+ E + ++ +D +L Q++ R Sbjct: 1341 EAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRN 1400 Query: 186 RQQEVTRKS 194 E ++ Sbjct: 1401 EVIEAANEA 1409 Score = 30.8 bits (68), Expect = 1.9 Identities = 35/188 (18%), Positives = 76/188 (40%), Gaps = 20/188 (10%) Query: 13 KEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELE-------AQLVQAEQRNRDL 65 KE+ + + L+ +Q + + E+ Q+ +E+E+ ++ Q +A ++L Sbjct: 1196 KEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQEL 1255 Query: 66 QADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQ----- 120 + ++++ L E HQ Q+ +++ L +L + + ++ + L + Sbjct: 1256 RLTREQVQNSHTELAE-ARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGAS 1314 Query: 121 --ANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEK-----ESLLVSVQRLKDE 173 LE +A I L + L +A E K +S SVQ+L ++ Sbjct: 1315 KVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQ 1374 Query: 174 ARDLRQEL 181 + EL Sbjct: 1375 LEKAKLEL 1382 Score = 30.4 bits (67), Expect = 2.4 Identities = 29/162 (17%), Positives = 67/162 (41%), Gaps = 8/162 (4%) Query: 32 EARDELVEFQEGSRELEA---ELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYA 88 + + EL + +ELE E +L +A Q+ L+ + Q E+++ +L+ Sbjct: 1029 QTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRD 1088 Query: 89 QSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIE 148 K LE+ + + + +L + E+E +L +A + +QR Q Sbjct: 1089 VLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTH 1148 Query: 149 RNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEV 190 + + E E ++ ++ + + EL ++E +++ Sbjct: 1149 LDMTIREHRGEMEQKIIKLEGTLE-----KSELELKECNKQI 1185 Score = 28.9 bits (63), Expect = 7.0 Identities = 31/149 (20%), Positives = 66/149 (44%), Gaps = 11/149 (7%) Query: 49 AELEAQLVQAEQRNRDLQA----DNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQT 104 AELE +L++ ++ R L+ +++++ E K+ Q+ + KQ+ LE L + Sbjct: 721 AELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKK 780 Query: 105 RAIKEQLHKYVRELEQ----ANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEK 160 ++ K + L+Q LE R S + ++ + E L++++ E+ Sbjct: 781 DQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEE 840 Query: 161 ESLLVSVQRLKDEARDLRQELAVRERQQE 189 + V++L ++EL + Q E Sbjct: 841 ---TIKVRQLDSALEICKEELVLHLNQLE 866 >gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] Length = 1411 Score = 50.8 bits (120), Expect = 2e-06 Identities = 60/285 (21%), Positives = 109/285 (38%), Gaps = 27/285 (9%) Query: 13 KEETAYWKELSLK-YKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 K+E E LK YK+ + + E + ++LEA+ EQ +DLQ Q Sbjct: 700 KQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQ- 758 Query: 72 LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQ----TRAIKEQLHKYVRELEQANDDLER 127 L ++E +L Q + VS DL + +IK++L K E + D E Sbjct: 759 LNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFET 818 Query: 128 AKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQ 187 + T + E+ R+ + L+ EKE+L+ + +KD+ + L + + Sbjct: 819 LSQETKIQHEELNNRIQTTVTE---LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSE 875 Query: 188 QEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENTFPSPKAIPNGFGTSPLTPS 247 E + ++ LD EK ++ L + ENT K + Sbjct: 876 FEKENQKGKAA-ILDLEKTCKELKHQLQVQ-------MENTLKEQKELKKSLEKEK---- 923 Query: 248 ARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKSYISGNVN 292 L ++ +++ +L +N K + + GN+N Sbjct: 924 ------EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNIN 962 Score = 47.8 bits (112), Expect = 1e-05 Identities = 50/224 (22%), Positives = 94/224 (41%), Gaps = 32/224 (14%) Query: 8 DFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQA 67 + + L EE K S+K + ++A+ L++ + EL+ + ++ EQ R+ Q Sbjct: 1139 EITKLNEELKSHKLESIKEITNLKDAKQLLIQQK---LELQGKADSLKAAVEQEKRNQQI 1195 Query: 68 DNQRLKYEVEALKE---------------------KLEHQYAQSYKQVSVLEDDLSQTRA 106 ++K E E LK+ K E A+ Q++ L ++L + Sbjct: 1196 LKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKK 1255 Query: 107 IKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVS 166 + + V ELE+ DDL ++++ + +ER E E+++ ++ ++ Sbjct: 1256 EWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLE 1315 Query: 167 VQRLKDEARDLRQELAVRERQ-------QEVTRKSAPSSPTLDC 203 +QR D QEL RE Q Q + RK A + +C Sbjct: 1316 LQRKLDNTTAAVQELG-RENQSLQIKHTQALNRKWAEDNEVQNC 1358 Score = 47.4 bits (111), Expect = 2e-05 Identities = 54/218 (24%), Positives = 103/218 (47%), Gaps = 38/218 (17%) Query: 12 LKEETAYWKELSL---KYKQSFQEAR----DELVEFQEGSRELEAELEAQLVQAEQRNRD 64 LKE+ EL K KQ QE + + +E +LE L Q+ +Q+ ++ Sbjct: 469 LKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR-QIGDKDQKIQN 527 Query: 65 LQADNQRLKYEVEALKEKLEHQYA-------------QSYKQVSVLEDDLSQ-TRAIKEQ 110 L+A Q+ K + L+++ E YA Q ++ L++ ++Q T +K Q Sbjct: 528 LEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQ 587 Query: 111 LHKYVRELEQANDDLE------RAKRATIVSLE----DFEQRLNQAIERNAFLESELDEK 160 + + E +D ++ RA + ++SLE + +LN++ E+ + L+ ++ K Sbjct: 588 SESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAK 647 Query: 161 ESLLVSVQRLKDEAR-DLRQEL-----AVRERQQEVTR 192 LL+S + K R DL+ L A++++QQE+ + Sbjct: 648 TELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNK 685 Score = 47.0 bits (110), Expect = 3e-05 Identities = 52/184 (28%), Positives = 89/184 (48%), Gaps = 18/184 (9%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEA---QLVQAEQRNRDLQAD 68 LK + E +LK ++ E + L + +E S +L+ EL + QL+QA+ + + + Sbjct: 897 LKHQLQVQMENTLKEQK---ELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953 Query: 69 NQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQL-HKYVRELEQANDDLER 127 Q+L+ + LK+ E Q KQ+ L+ +L K +L +K ++L QA +L Sbjct: 954 EQQLQGNINELKQSSE----QKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAA 1009 Query: 128 AKRATIVSLEDFEQRLNQAIERNAFLESELDEKES-LLVSVQRLK--DEARDLRQELAVR 184 K V ++E ++ E L+S+ +ES LL + Q LK +E L QE + Sbjct: 1010 EKEKISVLQNNYE----KSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLIS 1065 Query: 185 ERQQ 188 R Q Sbjct: 1066 NRNQ 1069 Score = 44.3 bits (103), Expect = 2e-04 Identities = 41/181 (22%), Positives = 87/181 (48%), Gaps = 24/181 (13%) Query: 41 QEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEK---LEHQYAQSYKQVSVL 97 Q+ +EL ++ QL Q + +D Q +L+ ++ KEK LE + + Q+ L Sbjct: 677 QDKQQELN-KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL 735 Query: 98 EDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESEL 157 E D + +A KEQ + +++ Q N DLE RAT +S + LE E Sbjct: 736 EADSLEVKASKEQALQDLQQQRQLNTDLE--LRATELSKQ---------------LEMEK 778 Query: 158 DEKESLLVSVQRLKDEARDLRQELAVRERQQEVTR---KSAPSSPTLDCEKMDSAVQASL 214 + S + +Q+ + ++Q+L +E ++++ + ++ + E++++ +Q ++ Sbjct: 779 EIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTV 838 Query: 215 S 215 + Sbjct: 839 T 839 Score = 38.9 bits (89), Expect = 0.007 Identities = 45/208 (21%), Positives = 87/208 (41%), Gaps = 26/208 (12%) Query: 10 SSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADN 69 + L ++ E LK +Q + + ++ E + ++A L + + +Q L A Sbjct: 298 NELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASE 357 Query: 70 -----------------QRLKYEVEALKEKLEH---QYAQSYKQVSVLEDDLSQTRAIKE 109 Q+LK E+ ++ K +H ++ Q +Q E Q ++ Sbjct: 358 TSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEIN 417 Query: 110 QLHKYV----RELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLV 165 QLH + R+L +A+ L+ ++ + L D EQ++ + + LE +L EK + Sbjct: 418 QLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNST 477 Query: 166 SVQRLKDEARDLRQELAVRERQQEVTRK 193 +Q D+ + QE + QQ T K Sbjct: 478 ELQHQLDKTKQQHQE--QQALQQSTTAK 503 Score = 37.7 bits (86), Expect = 0.015 Identities = 38/183 (20%), Positives = 81/183 (44%), Gaps = 34/183 (18%) Query: 31 QEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQS 90 Q+ + EL+ Q E A L+ +LVQ + ++ + +R +++ +KL+ QYA S Sbjct: 208 QDLKTELL--QRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASS 265 Query: 91 YKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERN 150 +S L +L++ +++ YV+EL++ + +N+ ++N Sbjct: 266 EATISQLRSELAKG---PQEVAVYVQELQK------------------LKSSVNELTQKN 304 Query: 151 AFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSAPSSPTLDCEKMDSAV 210 L L +KE ++ +E ++ + Q++ LDC+++ S + Sbjct: 305 QTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKD-----------LDCQQLQSRL 353 Query: 211 QAS 213 AS Sbjct: 354 SAS 356 Score = 36.6 bits (83), Expect = 0.034 Identities = 39/145 (26%), Positives = 70/145 (48%), Gaps = 25/145 (17%) Query: 60 QRNRDLQADNQRLKYEVEALKEKLEHQYA---QSYKQVSVLEDDLSQTRAIKEQLHKYVR 116 Q +DLQA + K+ E LK++LE Q K ++ D ++ +++++QL Sbjct: 90 QEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLE---- 145 Query: 117 ELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVS----VQRLKD 172 E + N ++++ K + FEQ+ Q A ++S+ DE+ SL + V RL + Sbjct: 146 EAQTENFNIKQMK-------DLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTE 198 Query: 173 E-------ARDLRQELAVRERQQEV 190 E +DL+ EL R ++V Sbjct: 199 ELNKEATVIQDLKTELLQRPGIEDV 223 Score = 33.9 bits (76), Expect = 0.22 Identities = 35/193 (18%), Positives = 86/193 (44%), Gaps = 29/193 (15%) Query: 34 RDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEA-----------LKEK 82 +D+L + + + ++E E + + + DL+ + LK++++ LK+ Sbjct: 859 KDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 918 Query: 83 LEHQYAQSY----------KQVSVLEDDLSQTRAIKEQLHKYVRELEQANDD-------L 125 LE + S+ +Q+ ++ L Q ++QL + EL+Q+++ L Sbjct: 919 LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 978 Query: 126 ERAKRATIVSLEDFEQRLNQAIERNA-FLESELDEKESLLVSVQRLKDEARDLRQELAVR 184 + + ++ + E +L Q + + A L +E ++ L + ++ ++ + L+ + R Sbjct: 979 QGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGR 1038 Query: 185 ERQQEVTRKSAPS 197 E + TR+ S Sbjct: 1039 ESELLATRQDLKS 1051 Score = 32.3 bits (72), Expect = 0.64 Identities = 40/183 (21%), Positives = 78/183 (42%), Gaps = 20/183 (10%) Query: 23 SLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQA---DNQRLKYEVEAL 79 S+K K + QE ++++ ++ E + +Q E+ N +Q + Q++K E EAL Sbjct: 797 SIKQKLTKQEEEKQILK-----QDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEAL 851 Query: 80 -------KEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRAT 132 K+KL S E + + +A L K +EL+ L+ T Sbjct: 852 MTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH---QLQVQMENT 908 Query: 133 IVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELA--VRERQQEV 190 + ++ ++ L + E + L+ EL+ + L+ Q + Q+L + E +Q Sbjct: 909 LKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSS 968 Query: 191 TRK 193 +K Sbjct: 969 EQK 971 >gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] Length = 2115 Score = 50.8 bits (120), Expect = 2e-06 Identities = 46/204 (22%), Positives = 91/204 (44%), Gaps = 19/204 (9%) Query: 29 SFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYA 88 + Q+ EL ++ ++E +A+L L Q EQ ++ L+ ++L +LK+K + Sbjct: 513 TIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLS---SSLKQKEQQLKE 569 Query: 89 QSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRL----- 143 + KQ + +D Q E+ +RE + A LE ++ LE +Q+L Sbjct: 570 VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANE 629 Query: 144 ---------NQAIERNAFLESELDEKESLLVSVQRLKDEARD--LRQELAVRERQQEVTR 192 QA A L +++E ++ + + ++ + EA+ EL +R QQ+ T Sbjct: 630 ARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATE 689 Query: 193 KSAPSSPTLDCEKMDSAVQASLSL 216 K + ++ A++ SL + Sbjct: 690 KERVAQEKDQLQEQLQALKESLKV 713 Score = 43.9 bits (102), Expect = 2e-04 Identities = 43/188 (22%), Positives = 80/188 (42%), Gaps = 9/188 (4%) Query: 13 KEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRL 72 +EE L + S E ++ S+ A L AQ+ L A Q+ Sbjct: 458 EEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQ 517 Query: 73 KYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRAT 132 E+ LK++ + + AQ + + E R EQL +++ EQ ++ + AT Sbjct: 518 DQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEAT 577 Query: 133 IVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTR 192 +D Q+L A E E+ L E+++ L ++ L+ E +L + ++Q +V Sbjct: 578 ---RQDHAQQLATAAEER---EASLRERDAALKQLEALEKEK---AAKLEILQQQLQVAN 628 Query: 193 KSAPSSPT 200 ++ S+ T Sbjct: 629 EARDSAQT 636 Score = 42.4 bits (98), Expect = 6e-04 Identities = 43/175 (24%), Positives = 81/175 (46%), Gaps = 11/175 (6%) Query: 20 KELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEAL 79 ++LS KQ Q+ + E+ E QE +R+ A+ A AE+R L+ + LK ++EAL Sbjct: 554 EQLSSSLKQKEQQLK-EVAEKQEATRQDHAQQLA--TAAEEREASLRERDAALK-QLEAL 609 Query: 80 -KEK------LEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRAT 132 KEK L+ Q + + + ++Q + K +L + V EL+ + + + Sbjct: 610 EKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEA 669 Query: 133 IVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQ 187 + + E +L ++ E EK+ L +Q LK+ + + L +R+ Sbjct: 670 QAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRR 724 Score = 41.6 bits (96), Expect = 0.001 Identities = 57/220 (25%), Positives = 93/220 (42%), Gaps = 23/220 (10%) Query: 6 IPDFSSLKEETAYWKELSLKYKQSFQEARDELV--------EFQEGSRELEAELEAQLVQ 57 + +L++E A E+ + Q EARD E E SR++E EL+A + Sbjct: 603 LKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVE-ELQACVET 661 Query: 58 AEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDL-SQTRAIKEQLHKYVR 116 A Q + QA L+ ++ + E Q A ++V+ +D L Q +A+KE L Sbjct: 662 ARQEQHEAQAQVAELELQLRS-----EQQKATEKERVAQEKDQLQEQLQALKESLKVTKG 716 Query: 117 ELEQ----ANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKD 172 LE+ A D LE +R + + Q LE E ++ L +Q+L Sbjct: 717 SLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQL-G 775 Query: 173 EARDLRQELAVRERQQEVTRKSAPSSPTLDCEKMDSAVQA 212 EA E+ RE + + + S +CE++ V A Sbjct: 776 EAHQAETEVLRRELAEAMAAQHTAES---ECEQLVKEVAA 812 Score = 41.2 bits (95), Expect = 0.001 Identities = 57/245 (23%), Positives = 98/245 (40%), Gaps = 44/245 (17%) Query: 12 LKEETAYWKELSLKYKQSFQE----ARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQA 67 L+E+ KE K S +E A D L E Q EL+AE + + Q ++ ++L+ Sbjct: 700 LQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEE 759 Query: 68 DNQRLK--------------YEVEALKEKLEHQYAQSYKQVSVLE-------------DD 100 + K E E L+ +L A + S E +D Sbjct: 760 ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYED 819 Query: 101 LSQTRA-----IKEQLHKYVRELEQANDDLERAKR--ATIVSLEDFE--QRLNQAIERNA 151 Q A +EQL E E+A +L+ AK A I S + + ++ N+ E +A Sbjct: 820 SQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHA 879 Query: 152 FLESELDEKESLLVSVQRLKDEARDLRQELAVRERQ----QEVTRKSAPSSPTLDCEKMD 207 L L + + V Q+L D+ L++++A ++ + + RK+ T E + Sbjct: 880 NLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVK 939 Query: 208 SAVQA 212 +A Sbjct: 940 EPARA 944 Score = 40.4 bits (93), Expect = 0.002 Identities = 54/197 (27%), Positives = 92/197 (46%), Gaps = 24/197 (12%) Query: 13 KEETAYWKELSLKYKQSFQEARDELVEFQEGSRELE--------AELEAQLVQAEQRNRD 64 +E+ KE K +Q QEA++++ + S EL+ AEL A L +A Q+ ++ Sbjct: 832 QEQLMTLKEECEKARQELQEAKEKVAGIESHS-ELQISRQQNELAELHANLARALQQVQE 890 Query: 65 LQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDL-----SQTRAIKEQLHKYVRELE 119 + Q+L ++ L+EK+ A + K+V+ LE + Q A +E + + R + Sbjct: 891 KEVRAQKLADDLSTLQEKM----AATSKEVARLETLVRKAGEQQETASRELVKEPARAGD 946 Query: 120 QANDDLERAKRATIVSLEDFEQRLNQAIERNA-FLESELDEKESLLVSVQRLKDEARDLR 178 + + LE + S Q QA+ER A + +EL+ + L+ Q + E R + Sbjct: 947 RQPEWLEEQQGRQFCS----TQAALQAMEREAEQMGNELERLRAALMESQGQQQEERG-Q 1001 Query: 179 QELAVRERQQEVTRKSA 195 QE V QE R A Sbjct: 1002 QEREVARLTQERGRAQA 1018 Score = 39.7 bits (91), Expect = 0.004 Identities = 34/137 (24%), Positives = 62/137 (45%), Gaps = 10/137 (7%) Query: 34 RDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKY------EVEALKEKLEHQY 87 RDEL +R+L E +AQ+ +QR L N++ E+E L++K E Sbjct: 230 RDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLT 289 Query: 88 AQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAI 147 + ++ + +D + K Q+ + + +L + N DL R L+ + LN+ Sbjct: 290 MRLHETLKQCQD----LKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELT 345 Query: 148 ERNAFLESELDEKESLL 164 E ++ E EK++ L Sbjct: 346 EEHSKATQEWLEKQAQL 362 Score = 39.7 bits (91), Expect = 0.004 Identities = 51/191 (26%), Positives = 89/191 (46%), Gaps = 28/191 (14%) Query: 21 ELSLKYKQ---SFQEARDELVEFQEGSRELEAELEAQLVQAEQRNR------DLQADNQR 71 ELS K ++ + AR E E Q ELE +L ++ +A ++ R LQ Q Sbjct: 647 ELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQA 706 Query: 72 LKYEVEALKEKLEHQYAQSY----KQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLER 127 LK ++ K LE + ++ +Q + + ++TR++ EQ + +ELE+ ER Sbjct: 707 LKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEE-----ER 761 Query: 128 AKRATIVSLEDFEQRLNQAIERNAFLESELDEKE--SLLVSVQRLKDEARDLRQELAV-R 184 A R + E RL Q E + E+E+ +E + + + E L +E+A R Sbjct: 762 AGR------KGLEARLQQLGEAHQ-AETEVLRRELAEAMAAQHTAESECEQLVKEVAAWR 814 Query: 185 ERQQEVTRKSA 195 ER ++ ++ A Sbjct: 815 ERYEDSQQEEA 825 Score = 39.7 bits (91), Expect = 0.004 Identities = 70/317 (22%), Positives = 138/317 (43%), Gaps = 37/317 (11%) Query: 13 KEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRL 72 +E+T +ELS K S Q ++ + ++L+A ++AQ +++Q + LQA L Sbjct: 1545 REQTKQVEELSKKLADSDQASKVQ-------QQKLKA-VQAQGGESQQEAQRLQAQLNEL 1596 Query: 73 KYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRAT 132 + ++ ++ EH Q K + + Q + ++EQL + + +L++ N +L RA+ Sbjct: 1597 QAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL-RSLEQLQKENKEL-RAE--- 1651 Query: 133 IVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTR 192 +RL +++ E ++ + + L + R L ++A ++Q Sbjct: 1652 -------AERLGHELQQAGLKTKEAEQ------TCRHLTAQVRSLEAQVAHADQQLRDLG 1698 Query: 193 KSAPSSPTLDCEKMDSAVQASLSLPATPVG--KGTENTFPS--PKAIPNGFGTSPLTPSA 248 K ++ L + + Q LS+ + + +GT + S P+ P+G P P++ Sbjct: 1699 KFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSV-PGEPAS 1757 Query: 249 RISALNIVGDLLRKVGALESKLAACRNFAKDQASRKSYISGNVNCGVLNGNGTKFSRSGH 308 IS L KV +LES L A+ QA +S + + + +G T+ +R Sbjct: 1758 PISQ-----RLPPKVESLES-LYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSARRRT 1811 Query: 309 TSFFDKGAVNGFDPAPP 325 T + D P Sbjct: 1812 TQIINITMTKKLDVEEP 1828 Score = 37.4 bits (85), Expect = 0.020 Identities = 32/152 (21%), Positives = 67/152 (44%), Gaps = 10/152 (6%) Query: 38 VEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVL 97 VE + + EL A AE R ++Q + Q E+E + K E + ++ Sbjct: 1467 VELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRF 1526 Query: 98 EDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESEL 157 +++ + A EQL + RE + ++L + L D +Q ++ ++++ Sbjct: 1527 QEERQKLTAQVEQLEVFQREQTKQVEELSK-------KLADSDQASKVQQQKLKAVQAQG 1579 Query: 158 DEKESLLVSVQRLKDEARDLRQELAVRERQQE 189 E + QRL+ + +L+ +L+ +E+ E Sbjct: 1580 GESQQ---EAQRLQAQLNELQAQLSQKEQAAE 1608 Score = 37.0 bits (84), Expect = 0.026 Identities = 50/207 (24%), Positives = 89/207 (42%), Gaps = 21/207 (10%) Query: 10 SSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADN 69 SSL+EE + L+ + +E + ++ E S++LE L +L+QAE + +A Sbjct: 1228 SSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERL--RLLQAETASNSARAAE 1285 Query: 70 QR--LKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVREL---EQANDD 124 + L+ EV++L+E+ E Q S L + + ++L + + EQA Sbjct: 1286 RSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALST 1345 Query: 125 LE---RAKRATIVSLEDFEQRLNQAIERNAFLE----SELDEKESL-------LVSVQRL 170 L+ + +A + L + Q A E EL++ + L+ QR Sbjct: 1346 LQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRE 1405 Query: 171 KDEARDLRQELAVRERQQEVTRKSAPS 197 E LRQ++A +ER + R S Sbjct: 1406 LGELIPLRQKVAEQERTAQQLRAEKAS 1432 Score = 32.0 bits (71), Expect = 0.83 Identities = 39/165 (23%), Positives = 74/165 (44%), Gaps = 28/165 (16%) Query: 39 EFQEGSRELE---AELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVS 95 E Q +RELE A+ E V+ + + Q + Q+L +VE L E + + + +++S Sbjct: 1497 EAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQL-EVFQREQTKQVEELS 1555 Query: 96 VLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLES 155 D Q +++Q K V+ Q + + A+R + +LN+ L++ Sbjct: 1556 KKLADSDQASKVQQQKLKAVQA--QGGESQQEAQR--------LQAQLNE-------LQA 1598 Query: 156 ELDEKESLL----VSVQRLK---DEARDLRQELAVRERQQEVTRK 193 +L +KE + +++ K D + QEL + R E +K Sbjct: 1599 QLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQK 1643 >gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1 [Homo sapiens] Length = 3259 Score = 50.8 bits (120), Expect = 2e-06 Identities = 50/189 (26%), Positives = 96/189 (50%), Gaps = 22/189 (11%) Query: 24 LKYKQSFQEARDELV-EFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEK 82 +K S Q RD +V ++Q+ LE + +++ +Q ++ A+N +LK E+ L+ Sbjct: 2463 VKSMSSLQNDRDRIVGDYQQ----LEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSH 2518 Query: 83 LEHQYAQSYK---QVSVLEDDLSQTRAIKEQLHKYVRELE-QANDDLERAKRATIVSLED 138 ++ +++ K ++ +DL+Q IK+ K + E++ Q N +LE L++ Sbjct: 2519 MDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKE 2578 Query: 139 FEQRLNQAIER--NAFLESELD---EKESLLVSVQRLKDEARDLRQE-------LAVRER 186 E+ N+ + R NA E + D E ESL VS+ +L + L++E ++ + Sbjct: 2579 SEE-ANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVK 2637 Query: 187 QQEVTRKSA 195 ++EV R SA Sbjct: 2638 EEEVHRLSA 2646 Score = 47.0 bits (110), Expect = 3e-05 Identities = 64/282 (22%), Positives = 119/282 (42%), Gaps = 46/282 (16%) Query: 10 SSLKEETAYW----KELSLKYK---QSFQEARDELVEFQ---EGSRELEAELEAQLVQAE 59 SS E+ W KEL +Y+ QS++ +E Q E R+ + EL +L E Sbjct: 1595 SSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTE 1654 Query: 60 QRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELE 119 ++ + Q + E+E +KEK+ ++A+S KQ +LE ++E+ + E+ Sbjct: 1655 ANKKETEKQLQEAEQEMEEMKEKM-RKFAKS-KQQKILE--------LEEENDRLRAEVH 1704 Query: 120 QANDDLERAKRATIVSLEDFEQRLNQAIERNAFL----ESELDEKESLLVSVQRLKDEAR 175 A D + + S ++ L + L +S + EK+SL VQ LK + Sbjct: 1705 PAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIE 1764 Query: 176 DLRQELA------VRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENTF 229 + A + Q VT + S P ++ Q SLS+ P Sbjct: 1765 GNVSKQANLEATEKHDNQTNVTEEGTQSIPG------ETEEQDSLSMSTRPT-------- 1810 Query: 230 PSPKAIPNGFGTSPLTPSARISALNIVGDLLRKVGALESKLA 271 +++P+ +P S S+ + + + L+++ L+ ++A Sbjct: 1811 -CSESVPSAKSANPAV-SKDFSSHDEINNYLQQIDQLKERIA 1850 Score = 43.5 bits (101), Expect = 3e-04 Identities = 54/262 (20%), Positives = 120/262 (45%), Gaps = 35/262 (13%) Query: 21 ELSLKYKQSFQEARDELVEFQE---GSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVE 77 ++ + +Q + + +L E +E G ++ L+ +L AEQRN+ L Q+++ E Sbjct: 245 DVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHN 304 Query: 78 ALKEKLEHQYAQSYKQVSVLEDDLSQTRA----IKEQLHKYVRELEQANDDLERAKRATI 133 L+ +E + +S + +E ++++ + ++E++H + + EQA Sbjct: 305 TLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQ---------- 354 Query: 134 VSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLK-------DEARDLRQELAVRER 186 + + E R + +++ ++E++EK S ++S+Q+ D +D +L + Sbjct: 355 -AQAELESRYSALEQKH---KAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKN 410 Query: 187 QQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENTFPSPKAIPNGF--GTSPL 244 +Q V +SA + L+ + + + S L P+ ++ S + P+ + GT + Sbjct: 411 EQAV--QSAQTIQQLEDQLQQKSKEISQFLNRLPL---QQHETASQTSFPDVYNEGTQAV 465 Query: 245 TPSARISALNIVGDLLRKVGAL 266 T S V +L + GAL Sbjct: 466 TEENIASLQKRVVELENEKGAL 487 Score = 40.0 bits (92), Expect = 0.003 Identities = 47/186 (25%), Positives = 84/186 (45%), Gaps = 35/186 (18%) Query: 29 SFQEARDELVEFQEGSRELEAELEAQLVQAEQRNR-----------DLQADNQRLKYEVE 77 + QE L+E E + + +AELE++ EQ+++ LQ Q L+ + Sbjct: 337 NLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACD 396 Query: 78 ALKEK-------LEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKR 130 ALK++ Q QS + + LED L Q +++ +++ L L++ + Sbjct: 397 ALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQK---SKEISQFLNRL-----PLQQHET 448 Query: 131 ATIVSLEDFEQRLNQAI--ERNAFLESEL----DEKESLLVS---VQRLKDEARDLRQEL 181 A+ S D QA+ E A L+ + +EK +LL+S ++ LK E L ++ Sbjct: 449 ASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQI 508 Query: 182 AVRERQ 187 + E Q Sbjct: 509 TLLEAQ 514 Score = 40.0 bits (92), Expect = 0.003 Identities = 43/183 (23%), Positives = 92/183 (50%), Gaps = 10/183 (5%) Query: 20 KELSLKYKQSFQEARDELVEFQEGSRELEAELEA-QLVQAEQRNRDLQADNQRLKYEVEA 78 +EL + +Q ++ + + + +QE LE ++A + VQ E + +DL+ + L VE Sbjct: 2011 QELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQ-KDLEITKENLAQAVEH 2069 Query: 79 LKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLED 138 ++K + + A S+K +L+D S+ + K +EL+ + E K ED Sbjct: 2070 -RKKAQAELA-SFK--VLLDDTQSEAARVLADNLKLKKELQ---SNKESVKSQMKQKDED 2122 Query: 139 FEQRLNQAIERNAFLESELDEK-ESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSAPS 197 E+RL QA E++ + + EK ++L L++ +++ L ++++ + +++ S Sbjct: 2123 LERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDS 2182 Query: 198 SPT 200 + T Sbjct: 2183 TVT 2185 Score = 38.1 bits (87), Expect = 0.012 Identities = 40/166 (24%), Positives = 76/166 (45%), Gaps = 30/166 (18%) Query: 36 ELVEFQ-EGSRELE---AELEAQLVQAEQRNRDL-------QADNQRLKYEVEALKEKLE 84 +L+E Q + ++ELE A+LE +L ++E+ N DL Q + Q L E+E+LK + Sbjct: 2553 QLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSIS 2612 Query: 85 HQYAQS------------YKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRAT 132 Q + Q+ V E+++ + A+ K + ELE+ +++ Sbjct: 2613 QLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKK 2672 Query: 133 IVSLED-FEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDL 177 + +ED ++ L + +E + E +R+ + ARDL Sbjct: 2673 VGEIEDKLKKELKHLHHDAGIMRNETETAE------ERVAELARDL 2712 Score = 37.7 bits (86), Expect = 0.015 Identities = 47/201 (23%), Positives = 93/201 (46%), Gaps = 18/201 (8%) Query: 4 EDIPDFSSLKE-ETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRN 62 E++ S KE E +L L+ K+ + + + E + E+ + ++VQ + Sbjct: 862 EELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEK 921 Query: 63 RDLQADNQRLKYEV-------EALKEKLE--HQYAQSYKQVSVLEDDLSQTRAI-KEQLH 112 L + + LK ++ EA KE++E ++ + KQ D++S I KE+L Sbjct: 922 FSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNY---DEMSPAGQISKEELQ 978 Query: 113 KYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQR--- 169 L++ N+ +R +A +++ ++ QR+++ E A L+ E +KE L +R Sbjct: 979 HEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDE-SKKEIPLSETERGEV 1037 Query: 170 LKDEARDLRQELAVRERQQEV 190 +D+ E V + QE+ Sbjct: 1038 EEDKENKEYSEKCVTSKCQEI 1058 Score = 37.4 bits (85), Expect = 0.020 Identities = 38/182 (20%), Positives = 76/182 (41%), Gaps = 6/182 (3%) Query: 8 DFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQA 67 + + L+ E K+ S ++ +++ + R+ EA+++ EQ DLQA Sbjct: 2306 ELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQA 2365 Query: 68 DNQ---RLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQ--TRAIKEQLHKYVRELEQAN 122 + RL E+ ++K+ + + + V +L Q + IKE L + + E+ N Sbjct: 2366 SRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKE-LENLLSQEEEEN 2424 Query: 123 DDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELA 182 LE + + + L + N +++LD + S+Q +D Q+L Sbjct: 2425 IVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLE 2484 Query: 183 VR 184 R Sbjct: 2485 ER 2486 Score = 35.8 bits (81), Expect = 0.058 Identities = 41/187 (21%), Positives = 81/187 (43%), Gaps = 16/187 (8%) Query: 42 EGSRELEAELEAQLVQAEQR-------NRDLQADNQRLKYEVEALKEKLEHQYAQSYKQV 94 E + E AEL LV+ EQ+ N+ L A Q + +L+ +H + + Sbjct: 2699 ETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELK 2758 Query: 95 SVLEDDLSQTRAIKEQ-LHKYVRE--LEQANDDLERAKRATIVSLEDFEQRL----NQAI 147 + L + +KEQ L R+ L + + + ++ LE Q+L Q + Sbjct: 2759 RKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLL 2818 Query: 148 ERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSA--PSSPTLDCEK 205 ++ LE ++ +S ++ L++E L EL + +E ++SA PS+ + + Sbjct: 2819 HLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQS 2878 Query: 206 MDSAVQA 212 + A+ + Sbjct: 2879 LKKAMSS 2885 Score = 33.5 bits (75), Expect = 0.29 Identities = 56/247 (22%), Positives = 99/247 (40%), Gaps = 42/247 (17%) Query: 11 SLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQ------------LVQA 58 +LKE + +ELSL AR + + ++E+++ AQ L+Q Sbjct: 1495 ALKENKSLQEELSL--------ARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQE 1546 Query: 59 EQRNRDLQAD-----NQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHK 113 E+ + D NQ L E+LK LE K V +E S A + + Sbjct: 1547 ERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQE 1606 Query: 114 YVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDE 173 +EL++ + L L+ +E N+A +E+ EK+ L ++ + Sbjct: 1607 KHKELQKEYEIL----------LQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEAN 1656 Query: 174 ARDLRQELAVRERQ----QEVTRKSAPS--SPTLDCEKMDSAVQASLSLPATPVGKGTEN 227 ++ ++L E++ +E RK A S L+ E+ + ++A + PA K Sbjct: 1657 KKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVH-PAGDTAKECME 1715 Query: 228 TFPSPKA 234 T S A Sbjct: 1716 TLLSSNA 1722 Score = 32.3 bits (72), Expect = 0.64 Identities = 45/236 (19%), Positives = 98/236 (41%), Gaps = 39/236 (16%) Query: 10 SSLKEETAYWKELSLKYKQSFQEA---RDELVEFQEGS--------RELEAELEAQLVQA 58 SSL+++ + + K+++ F +A ++E + +E + R++ +E + Sbjct: 2195 SSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINI 2254 Query: 59 EQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVREL 118 + D Q + + EV+ ++ + ++ + +S LE+ + + +L K EL Sbjct: 2255 SRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESEL 2314 Query: 119 EQANDDLE--------------------RAKRATI----VSLEDFEQRLNQAIERNAFLE 154 + D L R + A I S E E L + E + L Sbjct: 2315 KSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLH 2374 Query: 155 SELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSAPSSPTLDCEKMDSAV 210 E++ KE ++S+ K+EA ++A+ E +Q+ ++ L E+ ++ V Sbjct: 2375 EEINMKEQKIISLLSGKEEA----IQVAIAELRQQHDKEIKELENLLSQEEEENIV 2426 Score = 32.0 bits (71), Expect = 0.83 Identities = 39/179 (21%), Positives = 69/179 (38%), Gaps = 18/179 (10%) Query: 27 KQSFQEARDELVEFQEGSRELEAE---LEAQLVQAEQRNRDLQADNQRLKYEVEALKEKL 83 K QE +D+ FQ EL E + +L Q + +R+K + Sbjct: 2918 KAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDK 2977 Query: 84 EHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDD--------LERAKRATIVS 135 + Q + + L SQT+ +K Q + A+ D E + S Sbjct: 2978 DQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDS 3037 Query: 136 LEDFEQRLNQAIERNAFLESELDEKESLLVSV----QRLKDEAR---DLRQELAVRERQ 187 L++ Q+ + + N+ L+EK +L + + Q L++ + DL AV E+Q Sbjct: 3038 LKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQ 3096 Score = 31.2 bits (69), Expect = 1.4 Identities = 40/168 (23%), Positives = 74/168 (44%), Gaps = 36/168 (21%) Query: 32 EARDELVEFQEGSRELEAELEAQLVQAEQRNRDL-----QADNQRLKYEVEALKEKLEHQ 86 EA L + + +EL++ E+ Q +Q++ DL QA+ + LK E + ++EKL+ Sbjct: 2090 EAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLK-EKKNMQEKLDAL 2148 Query: 87 YAQSY-----------------KQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAK 129 + K+V L+++L T QL + + + DD +R Sbjct: 2149 RREKVHLEETIGEIQVTLNKKDKEVQQLQENLDST---VTQLAAFTKSMSSLQDDRDR-- 2203 Query: 130 RATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDL 177 I + +E++ + AI+ E E+ KE + LKD+ R + Sbjct: 2204 --VIDEAKKWERKFSDAIQSK---EEEIRLKED---NCSVLKDQLRQM 2243 Score = 28.9 bits (63), Expect = 7.0 Identities = 21/72 (29%), Positives = 38/72 (52%), Gaps = 13/72 (18%) Query: 38 VEFQEGSRELEAELEAQLVQAEQRNRDLQAD------------NQRLKYEVEALKEKLEH 85 +E +E E E +L +Q+ E +NR +AD N+R E+ ++ LE+ Sbjct: 492 IELEELKAENE-KLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLEN 550 Query: 86 QYAQSYKQVSVL 97 ++Q +K++SVL Sbjct: 551 TFSQKHKELSVL 562 >gi|149363685 hypothetical protein LOC23379 [Homo sapiens] Length = 2266 Score = 50.4 bits (119), Expect = 2e-06 Identities = 84/371 (22%), Positives = 148/371 (39%), Gaps = 74/371 (19%) Query: 10 SSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELE------AELEAQLVQAEQRNR 63 +SL++ + E + KQ + L E+Q+ EL+ + L Q+ + Q+ Sbjct: 24 ASLQQNLNEYVEALITLKQKIINTDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKIS 83 Query: 64 DLQADNQRL---KYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQ 120 LQ + L K E+E K L+ Y ++++ + ++++ ++ A K++L V++L++ Sbjct: 84 PLQKCQEELGSLKAELEEKKSSLK-LYQDTHQEYARVKEECLKSDAQKKKLEAKVKKLQE 142 Query: 121 ANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQE 180 A + +DF+Q N+ LE E + + L + K+E Sbjct: 143 A----------AVKQTQDFKQLRNE----KKILEKEFKKTQERLDEFSKQKNE------- 181 Query: 181 LAVRERQQEVTRKSAPSSPTLDCEKMDS-------AVQASLSLPATPVGKGTENTFPSP- 232 +E + T+ S+ S ++D K+ V + LP G+G+ P Sbjct: 182 ---KELRHIGTQISSDSYGSIDKRKVKLLLKELWLCVNTTHRLP----GEGSRCVPEKPA 234 Query: 233 -----KAIPNGFGTSPLTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKSYI 287 +P GT P T + + N V L K+ + C+N K +S + Sbjct: 235 KAITSSRVPGEDGTLPPTQGSPLRTSN-VQTCLTKLSMEIKEDFLCQNVEKQSSSGTNCS 293 Query: 288 SGNV-----NCGVL-----NGNGTKFSRSGHTSFFDKGAVNGFD----------PAPPPP 327 S +V N VL +G T+F H FFD+ D P P PP Sbjct: 294 SDHVFNENGNLEVLVQSHRDGGSTEFV--DHDHFFDEDLQAAIDFFKLPPPLLSPVPSPP 351 Query: 328 GLGSSRPSSAP 338 + S P S P Sbjct: 352 PMSSPHPGSLP 362 >gi|109255239 centrosomal protein 63 isoform b [Homo sapiens] Length = 541 Score = 50.4 bits (119), Expect = 2e-06 Identities = 63/294 (21%), Positives = 127/294 (43%), Gaps = 31/294 (10%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 ++E +E++++YKQ ++ +EL + +L+ + + + +R+ +++ +R Sbjct: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141 Query: 72 LKYEVEALKEK---LEHQYAQSYKQVSVLEDD----LSQTRAIKEQLHKYVRELEQA--- 121 L ++E ++K E Q +QVS LE Q+ I+ QL ++LE Sbjct: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELS 201 Query: 122 --------NDDLERAKR---ATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRL 170 + LERA A + +E R+N + + + E +KE L ++L Sbjct: 202 SQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKL 261 Query: 171 KDEARDLRQELAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENTFP 230 + ++ ++EL + QE A + EK+ V+A+ + A + E + Sbjct: 262 LEALQEEKRELKAALQSQENLIHEA----RIQKEKLQEKVKATNTQHAVEAIRPREESLA 317 Query: 231 SPKAIPNGFGTSPLTPSARISALNIVGDLLRK-----VGALESKLAACRNFAKD 279 K G G S +++ + DLL+ G+LES A C+ +++ Sbjct: 318 EKKYTSQGQGDLDSVLS-QLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQE 370 >gi|22095367 centrosomal protein 63 isoform a [Homo sapiens] Length = 703 Score = 50.4 bits (119), Expect = 2e-06 Identities = 63/294 (21%), Positives = 127/294 (43%), Gaps = 31/294 (10%) Query: 12 LKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQR 71 ++E +E++++YKQ ++ +EL + +L+ + + + +R+ +++ +R Sbjct: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141 Query: 72 LKYEVEALKEK---LEHQYAQSYKQVSVLEDD----LSQTRAIKEQLHKYVRELEQA--- 121 L ++E ++K E Q +QVS LE Q+ I+ QL ++LE Sbjct: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELS 201 Query: 122 --------NDDLERAKR---ATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRL 170 + LERA A + +E R+N + + + E +KE L ++L Sbjct: 202 SQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKL 261 Query: 171 KDEARDLRQELAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENTFP 230 + ++ ++EL + QE A + EK+ V+A+ + A + E + Sbjct: 262 LEALQEEKRELKAALQSQENLIHEA----RIQKEKLQEKVKATNTQHAVEAIRPREESLA 317 Query: 231 SPKAIPNGFGTSPLTPSARISALNIVGDLLRK-----VGALESKLAACRNFAKD 279 K G G S +++ + DLL+ G+LES A C+ +++ Sbjct: 318 EKKYTSQGQGDLDSVLS-QLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQE 370 Score = 34.3 bits (77), Expect = 0.17 Identities = 40/186 (21%), Positives = 77/186 (41%), Gaps = 27/186 (14%) Query: 11 SLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQ 70 SL+ +A K+LS Q E +EL + + E +AE++ Q Q + + + Sbjct: 356 SLESVSATCKQLS----QELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALE 411 Query: 71 RLKYEVEALKEKLEHQ--------------YAQSYKQVSVLEDDLSQTRAIKEQLHKYVR 116 +K E+ L ++L + + ++ ED + + I +QL Sbjct: 412 GMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKL 471 Query: 117 ELEQAND-------DLERAKRATIVSL-EDFEQRLNQAIERNAFLESEL-DEKESLLVSV 167 E ++ L AK ++ L E++ + LN+ + N L+ +L + K L +S Sbjct: 472 ENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEIST 531 Query: 168 QRLKDE 173 Q K + Sbjct: 532 QMCKKQ 537 >gi|34577114 cytomatrix protein p110 [Homo sapiens] Length = 957 Score = 50.4 bits (119), Expect = 2e-06 Identities = 44/188 (23%), Positives = 87/188 (46%), Gaps = 15/188 (7%) Query: 22 LSLKYKQSFQEARD-ELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALK 80 L L+ K+SF + +L + E L E+ E + R + ++++ E L+ Sbjct: 497 LRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLR 556 Query: 81 EKLEHQYAQSYKQVSVLEDDLSQT----RAIKEQLHKYVRELEQANDDLERAKRATIVSL 136 +K + Q +V L+ D S T ++E L + R +E+ + ER R + + Sbjct: 557 DK-DKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEI 615 Query: 137 EDFEQRLNQAIERNAFLESELDEKESLLVSVQR---------LKDEARDLRQELAVRERQ 187 E F + E+ L++EL EKES L+ ++ LK +++ E+A+ +++ Sbjct: 616 ESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKK 675 Query: 188 QEVTRKSA 195 +E ++ A Sbjct: 676 EECSKLEA 683 Score = 39.7 bits (91), Expect = 0.004 Identities = 45/201 (22%), Positives = 90/201 (44%), Gaps = 23/201 (11%) Query: 4 EDIPDFSSLKEETAYWKELSLKYKQSFQEARD-ELVEFQEGSRELEAELEAQ----LVQA 58 E++ S L+ E A K L Q+ E +D ++ + R+LE E++ ++ Sbjct: 358 EELHRRSQLQPEPAKTKAL-----QTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNT 412 Query: 59 EQRNRDLQ------ADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLH 112 E R +++ + ++ +K +++ LK++L + ++ + LE +Q K+ + Sbjct: 413 EDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIE 472 Query: 113 KYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKD 172 L + +RA I+ E RL E+ +FL + + + L L Sbjct: 473 VLKESLTA------KEQRAAILQTEVDALRLRLE-EKESFLNKKTKQLQDLTEEKGTLAG 525 Query: 173 EARDLRQELAVRERQQEVTRK 193 E RD++ L V+ER+ V +K Sbjct: 526 EIRDMKDMLEVKERKINVLQK 546 Score = 34.3 bits (77), Expect = 0.17 Identities = 39/142 (27%), Positives = 61/142 (42%), Gaps = 15/142 (10%) Query: 44 SRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQ 103 +++LE + AQL++ +R D ADN + ++E L LE + E D ++ Sbjct: 771 NQQLEKKKNAQLLEEVRRREDSMADNSQ-HLQIEELMNALEK---------TRQELDATK 820 Query: 104 TRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERN----AFLESELDE 159 R Q +E AN +ER K+ + LE ++ L AI A LE + Sbjct: 821 ARLASTQQSLAEKEAHLANLRIERRKQLEEI-LEMKQEALLAAISEKDANIALLELSASK 879 Query: 160 KESLLVSVQRLKDEARDLRQEL 181 K+ V LK E L +L Sbjct: 880 KKKTQEEVMALKREKDRLVHQL 901 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.310 0.128 0.347 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,347,018 Number of Sequences: 37866 Number of extensions: 659798 Number of successful extensions: 8517 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 362 Number of HSP's successfully gapped in prelim test: 765 Number of HSP's that attempted gapping in prelim test: 4542 Number of HSP's gapped (non-prelim): 3398 length of query: 345 length of database: 18,247,518 effective HSP length: 103 effective length of query: 242 effective length of database: 14,347,320 effective search space: 3472051440 effective search space used: 3472051440 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.8 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.