Guide to the Human Genome
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Search of human proteins with 13489095

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13489095 sialoadhesin precursor [Homo sapiens]
         (1709 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13489095 sialoadhesin precursor [Homo sapiens]                    3435   0.0  
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                   205   3e-52
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                   205   3e-52
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                   205   3e-52
gi|110349719 titin isoform N2-A [Homo sapiens]                        201   5e-51
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]            185   3e-46
gi|157168355 CD22 molecule [Homo sapiens]                             178   4e-44
gi|118572606 hemicentin 1 [Homo sapiens]                              170   1e-41
gi|11225258 myelin associated glycoprotein isoform a precursor [...   143   1e-33
gi|18104957 myelin associated glycoprotein isoform b precursor [...   143   1e-33
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]        134   6e-31
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact...   119   3e-26
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac...   119   3e-26
gi|98986445 carcinoembryonic antigen-related cell adhesion molec...   109   3e-23
gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Ho...   108   6e-23
gi|31377639 sialic acid binding Ig-like lectin 10 [Homo sapiens]      108   6e-23
gi|144226847 obscurin-like 1 [Homo sapiens]                           106   2e-22
gi|193794821 sialic acid binding Ig-like lectin 6 isoform 1 prec...   100   2e-20
gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Ho...    99   3e-20
gi|193794817 sialic acid binding Ig-like lectin 6 isoform 3 prec...    99   4e-20
gi|193794819 sialic acid binding Ig-like lectin 6 isoform 2 prec...    97   2e-19
gi|23943856 sialic acid binding Ig-like lectin 9 [Homo sapiens]        96   2e-19
gi|94538343 sialic acid binding Ig-like lectin 8 [Homo sapiens]        96   2e-19
gi|16506826 sialic acid binding immunoglobulin-like lectin-like ...    96   4e-19
gi|16506828 sialic acid binding immunoglobulin-like lectin-like ...    96   4e-19
gi|157694526 Fc receptor-like 5 [Homo sapiens]                         93   3e-18
gi|15147240 brother of CDO [Homo sapiens]                              92   4e-18
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa...    92   6e-18
gi|7657570 sialic acid binding Ig-like lectin 7 isoform 1 [Homo ...    91   1e-17
gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens]               90   2e-17

>gi|13489095 sialoadhesin precursor [Homo sapiens]
          Length = 1709

 Score = 3435 bits (8906), Expect = 0.0
 Identities = 1709/1709 (100%), Positives = 1709/1709 (100%)

Query: 1    MGFLPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWY 60
            MGFLPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWY
Sbjct: 1    MGFLPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWY 60

Query: 61   YDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEIS 120
            YDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEIS
Sbjct: 61   YDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEIS 120

Query: 121  EVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDP 180
            EVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDP
Sbjct: 121  EVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDP 180

Query: 181  ARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKG 240
            ARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKG
Sbjct: 181  ARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKG 240

Query: 241  VKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSDA 300
            VKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSDA
Sbjct: 241  VKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSDA 300

Query: 301  GVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSW 360
            GVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSW
Sbjct: 301  GVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSW 360

Query: 361  YKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF 420
            YKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF
Sbjct: 361  YKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF 420

Query: 421  LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRD 480
            LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRD
Sbjct: 421  LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRD 480

Query: 481  LEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPD 540
            LEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPD
Sbjct: 481  LEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPD 540

Query: 541  ARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQ 600
            ARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQ
Sbjct: 541  ARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQ 600

Query: 601  PTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCS 660
            PTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCS
Sbjct: 601  PTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCS 660

Query: 661  PRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQ 720
            PRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQ
Sbjct: 661  PRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQ 720

Query: 721  EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEA 780
            EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEA
Sbjct: 721  EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEA 780

Query: 781  GAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSL 840
            GAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSL
Sbjct: 781  GAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSL 840

Query: 841  GPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV 900
            GPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV
Sbjct: 841  GPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV 900

Query: 901  SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHC 960
            SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHC
Sbjct: 901  SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHC 960

Query: 961  QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020
            QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG
Sbjct: 961  QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020

Query: 1021 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080
            DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA
Sbjct: 1021 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080

Query: 1081 DFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVT 1140
            DFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVT
Sbjct: 1081 DFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVT 1140

Query: 1141 VRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPP 1200
            VRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPP
Sbjct: 1141 VRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPP 1200

Query: 1201 AQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG 1260
            AQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG
Sbjct: 1201 AQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG 1260

Query: 1261 VRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRAHAG 1320
            VRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRAHAG
Sbjct: 1261 VRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRAHAG 1320

Query: 1321 AYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALS 1380
            AYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALS
Sbjct: 1321 AYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALS 1380

Query: 1381 HDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRL 1440
            HDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRL
Sbjct: 1381 HDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRL 1440

Query: 1441 QVEGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTH 1500
            QVEGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTH
Sbjct: 1441 QVEGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTH 1500

Query: 1501 VARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEP 1560
            VARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEP
Sbjct: 1501 VARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEP 1560

Query: 1561 LASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620
            LASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG
Sbjct: 1561 LASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620

Query: 1621 SASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCKQSMGENSV 1680
            SASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCKQSMGENSV
Sbjct: 1621 SASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCKQSMGENSV 1680

Query: 1681 EMAFQKETTQLIDPDAATCETSTCAPPLG 1709
            EMAFQKETTQLIDPDAATCETSTCAPPLG
Sbjct: 1681 EMAFQKETTQLIDPDAATCETSTCAPPLG 1709


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score =  205 bits (522), Expect = 3e-52
 Identities = 356/1491 (23%), Positives = 543/1491 (36%), Gaps = 255/1491 (17%)

Query: 259  TLTCQVNSSYPAVSSIKWLKDGV------RLQTKTG--VLHLPQAAWSDAGVYTCQAENG 310
            T++ Q  +    V +I WL++G+      RLQ      VL +  A  +DA  Y C AEN 
Sbjct: 1671 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ 1730

Query: 311  VGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLR------YSWYKNH 364
             GS         +F   VQV P    L+ + VT + N+    P D+        +WYK+ 
Sbjct: 1731 AGSAEK------LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDS 1784

Query: 365  VLLEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSERS-GPVSVVV----NHPP 412
              L           +HTL+L  A  +D+G Y CE  N  G ++    +SV+V       P
Sbjct: 1785 QALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAP 1844

Query: 413  LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPN 472
              P     +  + G   +L C   + P  T+     G  L           R     G  
Sbjct: 1845 RGPQDAVLV--RVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQ-------RTQALRGGQ 1895

Query: 473  SLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE---GQAVTL 529
              RLEI++ + +D G Y C  +N  G A  T            +P  E V    G  + L
Sbjct: 1896 --RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVL 1953

Query: 530  SCRSGLSPTPDARFSWY-----LNGALLH--EGPGSSLLLPAASSTDAGSYHCRARDGHS 582
            +C   +S  P    +W      +  + +H     G  L L       AG+Y C A +  +
Sbjct: 1954 TC--DVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA 2011

Query: 583  ASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRV 642
             +      V+ VL  PR  +     +        G+   L C  D  PP  +  L     
Sbjct: 2012 EA--RKDFVVAVLVAPRIRSSGVAREHHVL---EGQEVRLDCEADGQPPPDVAWLKDGSP 2066

Query: 643  VATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSA 702
            +   +         GG S  +K  +A              + G Y C A N  G  +   
Sbjct: 2067 LGQDMGPHLRFYLDGG-SLVLKGLRA-------------SDAGAYTCVAHNPAGEDARLH 2112

Query: 703  TFNGQATVLAIAPSHTLQEGTEAN---------LTCNVSREAAGSPANFSWFRNGV---- 749
            T N     + + P  T+++G + +         L   V       P + SW ++G+    
Sbjct: 2113 TVN-----VLVPP--TIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL 2165

Query: 750  ---LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLD 806
                   G   T+ +  V   DA ++ C   + AG        L V  PP    +    D
Sbjct: 2166 SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGV-ADRNFTLQVQVPPVLEPVEFQND 2224

Query: 807  --MGQGHMALFICTVDSRPLALLA-LFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
              + +G +    C     PL L++ +  GE LL+ SL  Q PS              L++
Sbjct: 2225 VVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSL-EQGPS--------------LQL 2269

Query: 864  RELGLGDSGSYRCEATNVLGSSNTSLFFQV-RGAWVQVSPSP---ELQEGQAVVLSCQVH 919
              +G GDSG+Y C A +  G +       V     ++ S  P    L  G  + L C   
Sbjct: 2270 EAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 2329

Query: 920  TGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSA-----TTSLAA 974
             G P+  +  W++DGQ L    + +     + +  AG Y C A++P  A        + A
Sbjct: 2330 -GTPQ-PNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQA 2387

Query: 975  PISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034
            P ++     PR V     +   PG+L +L C V+++P  ++   H D +V          
Sbjct: 2388 PPNIVGPRGPRFV-----VGLAPGQL-VLECSVEAEPAPKI-TWHRDGIVL--------- 2431

Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG 1094
                   H         L++      D G Y C A N  G  S        A  V++   
Sbjct: 2432 ---QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSV-------AFRVEIHTV 2481

Query: 1095 ATVREGQ-----LVNLTCLVWTTH---PAQLTYTWYQDGQ---------QRLDAHSIPLP 1137
             T+R G       VN T L+       PA L  +W +D           + L   S+ + 
Sbjct: 2482 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLV-SWRKDRVPLDPRSPRFEILPEGSLRIQ 2540

Query: 1138 NVTVRDATSYRC------GVGPPGRAPRLSRPITLDVLYAPRNLRLT------YLLESHG 1185
             V  +DA  Y C      G    GR  R+  P    +  +P NL LT         E+ G
Sbjct: 2541 PVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPA--IAPSPSNLTLTAHTPALLPCEASG 2598

Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARS 1245
                LV+   D +         A RLL S+          L L  P P+D   + C   +
Sbjct: 2599 SPKPLVVWWKDGQKLDFRLQQGAYRLLPSNA---------LLLTAPGPQDSAQFECVVSN 2649

Query: 1246 PLGQANTSLELRLEGVRVILAPEAA-------VPEGAPITVTCADPAAHAPTLYTWYHNG 1298
             +G+A+     RL  V V + P  A       V   AP+ +TC      APT+ +W   G
Sbjct: 2650 EVGEAH-----RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTV-SWSKAG 2703

Query: 1299 RWL-------QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVL 1351
              L       +  P+ +L    A   HAG Y+C A+++ G  + +   L V  +P    L
Sbjct: 2704 AQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPL 2762

Query: 1352 SSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRL 1411
             S   + A    ++ C     P   +    +G  +AT  GV +     G +++A  +   
Sbjct: 2763 PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVAT--GVSTQVLPGGQLRIAHAS--- 2817

Query: 1412 QVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAE--PGLDVPEGAALNLSCRLLG 1469
                 P     Y+C A+N  GS     RL V+   V+    P L   EG+   L C+  G
Sbjct: 2818 -----PEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARG 2872

Query: 1470 GPGPVGNSTFAWFWN---------DRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAA 1520
             P P  N T    W+         + +   +P   L   ++    AG Y C AE   G A
Sbjct: 2873 SPEP--NIT----WDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRA 2926

Query: 1521 ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQG 1580
                V L +L  P   T+        G R  L C     P   +   +  R V       
Sbjct: 2927 RRR-VHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG---- 2981

Query: 1581 APAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
                    V        +   A+   D G Y+C A N +G     ++  V+
Sbjct: 2982 --------VSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 3024



 Score =  202 bits (513), Expect = 3e-51
 Identities = 373/1573 (23%), Positives = 580/1573 (36%), Gaps = 263/1573 (16%)

Query: 194  TGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNIL 253
            + VG L  L  A   Q+      C   V N  +  ++ L+V   P+       P+  +++
Sbjct: 1023 SAVGRLLYLGQAQLAQEGTYTCECSNVVGN--SSQDLQLEVHVPPQIAGPREPPTQVSVV 1080

Query: 254  PGELVTLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTC 305
               + TL C      P   ++ W +DG        ++LQ +   LH+ +A  +  G Y+C
Sbjct: 1081 QDGVATLECNATGKPPP--TVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 1138

Query: 306  QAENGVGSLVSPPISLHIFMAEVQVSPAGPILE-----NQTVTLVCNTPNEAPSDLRYSW 360
             AEN  G        L + +    +    P+       +  +TL+C      P  +R  W
Sbjct: 1139 VAENLAGR-AERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIR--W 1195

Query: 361  YKNHVLL---EDAH----SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413
            ++    +   ED +       L++      D+G Y C   N  G  R    SV V  PP 
Sbjct: 1196 FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRN-FSVEVLVPPS 1254

Query: 414  --TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGP 471
                 L   ++   G    L C+V   P   L     G  LA   GD+ H         P
Sbjct: 1255 IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR--GDAHHI-------SP 1305

Query: 472  NSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAE-------VVEG 524
            + + L++     + +G Y C A N++G  T         A  ++  A +       V   
Sbjct: 1306 DGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVN 1365

Query: 525  QAVTLSCRSGLSPTPDARFSWYLNGALLHEG------PGS-SLLLPAASSTDAGSYHCRA 577
              ++L C +   P+P+   +W  +GA           PG+  L +  A   DAG Y C  
Sbjct: 1366 NPISLICEALAFPSPN--ITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVV 1423

Query: 578  RDGHSASGPSSPAVLTVLYPPR--QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635
             +    +  +    + VL PP   +      + +            L C   + PP  ++
Sbjct: 1424 TNELGEAVKNYH--VEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIR 1481

Query: 636  LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695
              +KD    T              S R++V     LL+++     + + G YLC A+N  
Sbjct: 1482 W-YKDGQPVTP-------------SSRLQVLGEGRLLQIQPTQ--VSDSGRYLCVATNVA 1525

Query: 696  GNASTS--------------ATFNGQATVLA--------IAPSHTLQEGTEANLTCNVSR 733
            G                     F+    +L+        +     + E   A L C+ + 
Sbjct: 1526 GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTN- 1584

Query: 734  EAAGSPANFSWFRNGVLWAQGPLETVTL------LPVARTD-AALYACRILTEAGAQLST 786
              A  P + +W+R     + G   +V        +P+ R + A  Y+C+   E G     
Sbjct: 1585 --AIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 1642

Query: 787  PVLLSVLYPP----DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGP 842
              LL VL PP    D  +L   + +         C     P+  ++        + S   
Sbjct: 1643 YELL-VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRL 1701

Query: 843  QVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSP 902
            QV   G+           L+V    + D+ SY C A N  GS+     F +R   VQV P
Sbjct: 1702 QVLEDGQV----------LQVSTAEVADAASYMCVAENQAGSAEK--LFTLR---VQVPP 1746

Query: 903  ---SPELQEGQAVV-----LSCQVHTGV-PEGTSYRWYRDGQPLQESTSA-------TLR 946
                 +L++  A++     L C VH    PE T   WY+D Q L             TL+
Sbjct: 1747 RIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT---WYKDSQALSLGEEVFLLPGTHTLQ 1803

Query: 947  FAAITLTQAGAYHCQA-QAPG--SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLL 1003
                 L+ +G Y C+A  A G       L+  +      APR      L+  G     +L
Sbjct: 1804 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDK--AVL 1861

Query: 1004 LCRVDSDP-PAQLRLLHGDRLV-ASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061
             C  D+ P P       G  LV A   Q + G +               RLEI  A + D
Sbjct: 1862 SCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ---------------RLEIQEAQVSD 1906

Query: 1062 EGVYICEASNTLGQASASADFDAQAVNVQVWPGA-TVRE--GQLVNLTCLVWTTHPAQLT 1118
            +G+Y C+ SN  G+A  +     Q       P   TV +  G  + LTC V +  PA  T
Sbjct: 1907 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAP-T 1964

Query: 1119 YTWYQDGQQRLDAHSIPLPNVTVR------------DATSYRCGVGPPGRAPRLSRPITL 1166
             TW +D   R+   S  +  V  R             A +Y C         R  +   +
Sbjct: 1965 VTWLKD---RMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR--KDFVV 2019

Query: 1167 DVLYAPRNLRLTYLLESH---GGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT 1223
             VL APR +R + +   H    GQ   + C  D +PP  +A    G  L       +   
Sbjct: 2020 AVLVAPR-IRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY 2078

Query: 1224 L---RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP---EAAVPEGAPI 1277
            L    L L+G +  D G Y+C A +P G+     + RL  V V++ P   + A   G  +
Sbjct: 2079 LDGGSLVLKGLRASDAGAYTCVAHNPAGE-----DARLHTVNVLVPPTIKQGADGSGTLV 2133

Query: 1278 T-----VTCADPAAHAPTLY-TWYHNG-------RWLQEGPAASLSFLVATRAHAGAYSC 1324
            +     VT   P   +P ++ +W  +G       R L  G   +L       A AG ++C
Sbjct: 2134 SRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC 2193

Query: 1325 QAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRA--RSMAVIQCTVDSEPPAELALSHD 1382
             A    G  + R   LQV   P    +    D      S+  + C     P   ++   D
Sbjct: 2194 VAASPAGV-ADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD 2252

Query: 1383 GKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQ 1441
            G+ L +     SL  G            LQ++ V AGD  TY C A +  G      +L 
Sbjct: 2253 GEPLLS----QSLEQGPS----------LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 2298

Query: 1442 VEGARVVAEPG----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLA 1497
            V     + + G    L +  GA + L C   G P P       W  + + L      + A
Sbjct: 2299 VMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQP----NITWHKDGQALTRLENNSRA 2354

Query: 1498 FTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYP-----PKTPTMMVFVEPEGGLRGIL 1552
               +    AG+Y CLAE P GA   +   +RV  P     P+ P  +V + P G L  +L
Sbjct: 2355 TRVLRVRDAGLYTCLAESPAGAIEKS-FRVRVQAPPNIVGPRGPRFVVGLAP-GQL--VL 2410

Query: 1553 DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612
            +C V++EP   +T H            G   +   H         + ++AL  +D G+Y 
Sbjct: 2411 ECSVEAEPAPKITWH----------RDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYS 2460

Query: 1613 CSASNVLGSASTS 1625
            C+A N  GS S +
Sbjct: 2461 CTARNAAGSTSVA 2473



 Score =  201 bits (510), Expect = 7e-51
 Identities = 379/1557 (24%), Positives = 563/1557 (36%), Gaps = 298/1557 (19%)

Query: 258  VTLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTCQAEN 309
            V+L C V++ +P    + W KD         V L   T  L L +A  SD+G+YTC+A N
Sbjct: 1764 VSLPCDVHA-HPN-PEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALN 1821

Query: 310  GVG---SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVL 366
              G    LV   + +     +    P   +L       V +   +A  +   +WYK+   
Sbjct: 1822 AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQP 1881

Query: 367  LEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPP-LTPVLT 418
            L  A           L +  A  +D G Y C+V NV G E     ++ V  PP      T
Sbjct: 1882 LVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKT 1940

Query: 419  AFLETQAGLVGILHCSVVSEPLATL--------VLSHGGHILASTSGDSDHSPRFSGTSG 470
              +   AG   +L C V   P  T+        V S   H + S  G             
Sbjct: 1941 ETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGG------------- 1987

Query: 471  PNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN---AARLLISPAAE---VVEG 524
                RL++  L+   +G Y C A N+   A    DF      A R+  S  A    V+EG
Sbjct: 1988 ----RLQLSRLQPAQAGTYTCVAENTQAEARK--DFVVAVLVAPRIRSSGVAREHHVLEG 2041

Query: 525  QAVTLSCRSGLSPTPDARFSWYLNGALLHE--GP-------GSSLLLPAASSTDAGSYHC 575
            Q V L C +   P PD   +W  +G+ L +  GP       G SL+L    ++DAG+Y C
Sbjct: 2042 QEVRLDCEADGQPPPDV--AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2099

Query: 576  RARDGHSASGPSSPA-VLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLL---CRVDSDPP 631
             A   H+ +G  +    + VL PP     T +   D +G    R G L+   C V   PP
Sbjct: 2100 VA---HNPAGEDARLHTVNVLVPP-----TIKQGADGSGTLVSRPGELVTMVCPVRGSPP 2151

Query: 632  ARLQLL------------------HKDRVVATSLPSGGGCSTCGGCSPR--------MKV 665
              +  L                  H  R+    L +  G  TC   SP         ++V
Sbjct: 2152 IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQL-ADAGIFTCVAASPAGVADRNFTLQV 2210

Query: 666  TKAPNLLRVEIHNPLLEEEGLYL---CEASN----------------------------- 693
               P L  VE  N ++   G  +   CEA                               
Sbjct: 2211 QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLE 2270

Query: 694  ALGNASTSATFN-------GQAT----VLAIAPSHTLQEG--TEANLTCNVSRE----AA 736
            A+G A  S T++       G+A     +  + P H    G  TE +LT     E    A 
Sbjct: 2271 AVG-AGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 2329

Query: 737  GSPA-NFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP 795
            G+P  N +W ++G    +    +     +   DA LY C   + AGA +     + V  P
Sbjct: 2330 GTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGA-IEKSFRVRVQAP 2388

Query: 796  PD-----RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRF 850
            P+      P+    L  GQ    +  C+V++ P   +       +L      Q P  GRF
Sbjct: 2389 PNIVGPRGPRFVVGLAPGQ---LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF 2445

Query: 851  QAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV----SPSPEL 906
                      L+++ L   DSG Y C A N  GS  TS+ F+V    V       P+  +
Sbjct: 2446 ----------LQLQALSTADSGDYSCTARNAAGS--TSVAFRVEIHTVPTIRSGPPAVNV 2493

Query: 907  QEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST-------SATLRFAAITLTQAGAYH 959
               Q  +L CQ   GVP      W +D  PL   +         +LR   +    AG Y 
Sbjct: 2494 SVNQTALLPCQAD-GVP-APLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL 2551

Query: 960  CQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDP-PAQLRL 1017
            C A  + GS        +    + AP    LT    T      LL C     P P  +  
Sbjct: 2552 CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTP----ALLPCEASGSPKPLVVWW 2607

Query: 1018 LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQAS 1077
              G +L     QG      S+  L  A  P            +D   + C  SN +G+A 
Sbjct: 2608 KDGQKLDFRLQQGAYRLLPSNALLLTAPGP------------QDSAQFECVVSNEVGEAH 2655

Query: 1078 ASADFDAQAVNVQVWPGATVREGQ----LVNLTCLVWTTHPAQL---TYTWYQDGQQRLD 1130
                     V V V P  T+ + Q    +  +  +V T H   +   T +W + G Q L 
Sbjct: 2656 R-----LYQVTVHVPP--TIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ-LG 2707

Query: 1131 AHSIPLPNVTVRDATSYRCGVGPPGRAPRLS-----------RPITLDVLYAPRNLRLTY 1179
            A         V  + +   G   P  A R +           + + L V  +P    L  
Sbjct: 2708 ARG---SGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPS 2764

Query: 1180 LLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFY 1239
            ++ +   +  L+ C     P   +     G  +A+  +  V    +L +    P D G Y
Sbjct: 2765 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNY 2824

Query: 1240 SCSARSPLGQA--NTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN 1297
             C A++  G A   T L +++  V     P+ +  EG+   + C    +  P + TW  +
Sbjct: 2825 LCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNI-TWDKD 2883

Query: 1298 GRWLQ--EG-----PAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAV 1350
            G+ +   EG     P+  L         AG Y+C A++A G R+ R   L +L  P    
Sbjct: 2884 GQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG-RARRRVHLTILVLPVFTT 2942

Query: 1351 LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR 1410
            L   R  R      ++C     P   +  + + + +          S      V+R    
Sbjct: 2943 LPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSRE--- 2999

Query: 1411 LQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV---AEPGLDVPEGAALNLSCRL 1467
                       TYVC A+N +G    +  + V+ A V+   A   L  P G ++ L C +
Sbjct: 3000 --------DSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV 3051

Query: 1468 LGGPGPVGNSTFAWFWNDRRL------HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAA 1521
             G P P       W  +   L      H     +L      R  AG Y CLAE   G A 
Sbjct: 3052 RGDPVP----DIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAK 3107

Query: 1522 SAPVMLRVLYPPKTPTMMVF-VEPE-----GGLRGILDCRVDSEPLASLT-LHLGSRLVA 1574
               +++    P       VF VEP+      G    L C+   EP  ++  L  G  L A
Sbjct: 3108 KVVILVLQSAP-------VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRA 3160

Query: 1575 SSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
            S + +  P               + +E +   D G Y C A N+LGSA+   +  VR
Sbjct: 3161 SRRLRTLPDGS------------LWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3205



 Score =  179 bits (454), Expect = 2e-44
 Identities = 398/1681 (23%), Positives = 604/1681 (35%), Gaps = 297/1681 (17%)

Query: 100  LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRV---PTIASPVELLEGTEV 156
            L ++  Q  D+GSY  R   S V   ++++  L  V   PR+   P++  PV  L  T V
Sbjct: 750  LRIEQAQLSDAGSY--RCVASNVAGSTELRYGL-RVNVPPRITLPPSLPGPV--LVNTPV 804

Query: 157  DFNCSTPYVCLQEQVRLQW--QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRI 214
               C+           L W   G   + + T   Q F     G + TL  A +  D GR 
Sbjct: 805  RLTCNATGA---PSPTLMWLKDGNPVSPAGTPGLQVFPG---GRVLTLASARA-SDSGRY 857

Query: 215  LRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSI 274
                +S      Q ++ LQV   P    IL      +++  E V L CQ ++  P V S 
Sbjct: 858  SCVAVSAVGEDRQ-DVVLQVHMPPS---ILGEELNVSVVANESVALECQSHAMPPPVLS- 912

Query: 275  KWLKDGVRLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA 326
             W KDG  L+ + GV        L + +A   DAG YTC+A N  G       S   +  
Sbjct: 913  -WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGR------SEKHYNL 965

Query: 327  EVQVSPAGPILENQTVTLVCNTPNEAPSDLR------YSWYKNHVLLE---------DAH 371
             V V+P  P+ E+ T+T+    P     + R       SW K+   L           A 
Sbjct: 966  NVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAV 1025

Query: 372  SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTP----VLTAFLETQAGL 427
               L L  A  A  G Y CE  NV G+  S  + + V+ PP         T     Q G 
Sbjct: 1026 GRLLYLGQAQLAQEGTYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDG- 1083

Query: 428  VGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
            V  L C+   +P  T+     G  + +  G    +   S         L +   +   +G
Sbjct: 1084 VATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQS---------LHVERAQAAHTG 1134

Query: 488  EYKCSATNSLGNATSTLDFHANAARLLIS---PAAEVVEG--QAVTLSCRSGLSPTPDAR 542
             Y C A N  G A    +        LI    P   +       +TL C +   P P  R
Sbjct: 1135 RYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIR 1194

Query: 543  FSWYLNGALLHEGPGSSLL-------LPAASSTDAGSYHCRARDGHSASGPSSPAVLTVL 595
              W+     +  G  + LL       +      D+G Y C A   + A        + VL
Sbjct: 1195 --WFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA--SNEAGEARRNFSVEVL 1250

Query: 596  YPPRQPTFTTRLDLDAA-GAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCS 654
             PP         DL+       G+   L+C V   P  +L      R +A          
Sbjct: 1251 VPPS----IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR--------- 1297

Query: 655  TCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIA 714
               G +  +    +P+ + +++    L   G Y C A+NA+G      T + Q +VL +A
Sbjct: 1298 ---GDAHHI----SPDGVLLQVLQANLSSAGHYSCIAANAVG----EKTKHFQLSVL-LA 1345

Query: 715  PS--HTLQEGTEANLTCNVSR------EAAGSPA-NFSWFRNGVLWAQGPLETVTLLP-- 763
            P+     ++  +  +T  V+       EA   P+ N +W ++G  +       + LLP  
Sbjct: 1346 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEAS--RNIQLLPGT 1403

Query: 764  -------VARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFI 816
                     + DA  Y C +  E G  +     + VL PP   K   L ++G   +   +
Sbjct: 1404 HGLQILNAQKEDAGQYTCVVTNELGEAVKN-YHVEVLIPPSISKDDPLGEVGVKEVKTKV 1462

Query: 817  -------CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869
                   C   + P   +  +     +  S   QV   GR           L+++   + 
Sbjct: 1463 NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL----------LQIQPTQVS 1512

Query: 870  DSGSYRCEATNVLGSSNTSL--------FFQVRG--------------AWVQVSPSPELQ 907
            DSG Y C ATNV G  +            FQ  G              A   V+   E+ 
Sbjct: 1513 DSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIV 1572

Query: 908  EGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT-------LRFAAITLTQAGAYHC 960
            E     L C  +   P   +  WYR+ QPL      +       L+   +    AG Y C
Sbjct: 1573 ENNPAYLYCDTNAIPPPDLT--WYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSC 1630

Query: 961  QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020
            +A       ++      LH  Y    +T   ++      +  +     S    Q   L  
Sbjct: 1631 KA-------SNEVGEDWLH--YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN 1681

Query: 1021 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080
                 S LQ  G P   SPRL V        L++  A + D   Y+C A N  G A    
Sbjct: 1682 PVPTISWLQN-GLPFSPSPRLQVLEDGQV--LQVSTAEVADAASYMCVAENQAGSAE--- 1735

Query: 1081 DFDAQAVNVQVWP--------GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL--- 1129
                  + VQV P          T      V+L C V   HP     TWY+D Q      
Sbjct: 1736 --KLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDV-HAHP-NPEVTWYKDSQALSLGE 1791

Query: 1130 ------DAHSIPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVL------YAPRNLR 1176
                    H++ L    + D+  Y C  +   GR  +L   + L VL       APR  +
Sbjct: 1792 EVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL---VQLSVLVPPAFRQAPRGPQ 1848

Query: 1177 LTYLLESHGGQLALVLCTVDSRPPAQLALSHAGR-LLASSTAASVPNTLRLELRGPQPRD 1235
               L+    G  A++ C  D+ P   +     G+ L+ +    ++    RLE++  Q  D
Sbjct: 1849 DAVLVRV--GDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSD 1906

Query: 1236 EGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE---GAPITVTCADPAAHAPTLY 1292
            +G YSC   +  G+A  +  L ++       P+        G+P+ +TC      APT+ 
Sbjct: 1907 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV- 1965

Query: 1293 TWYHNGRWLQEGP-------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYA 1345
            TW  +   ++             L       A AG Y+C A++ Q   + +   + VL A
Sbjct: 1966 TWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQ-AEARKDFVVAVLVA 2024

Query: 1346 PQDAVLSSFRDSRARSMAVIQ--CTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403
            P+       R+        ++  C  D +PP ++A   DG  L    G H      G   
Sbjct: 2025 PRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSL 2084

Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV-------EGA----RVVAEPG 1452
            V +    L+  D  A    Y C A N  G  + +  + V       +GA     +V+ P 
Sbjct: 2085 VLKG---LRASDAGA----YTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRP- 2136

Query: 1453 LDVPEGAALNLSCRLLGGPGPVGNSTFAWF-------WNDRRLHAEPVPTLAFTHVARAQ 1505
                 G  + + C + G P P+  S   W         + R L      TL  + V  A 
Sbjct: 2137 -----GELVTMVCPVRGSP-PIHVS---WLKDGLPLPLSQRTLLHGSGHTLRISKVQLAD 2187

Query: 1506 AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI---LDCRVDSEPLA 1562
            AG++ C+A  P G  A     L+V  PP     + F      +RG    L C     PL 
Sbjct: 2188 AGIFTCVAASPAG-VADRNFTLQVQVPPVLEP-VEFQNDVVVVRGSLVELPCEARGVPLP 2245

Query: 1563 SLT-LHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621
             ++ +  G  L++ S  QG                 + +EA+   D G Y C A +  G 
Sbjct: 2246 LVSWMKDGEPLLSQSLEQGP---------------SLQLEAVGAGDSGTYSCVAVSEAGE 2290

Query: 1622 A 1622
            A
Sbjct: 2291 A 2291



 Score =  176 bits (445), Expect = 2e-43
 Identities = 378/1579 (23%), Positives = 578/1579 (36%), Gaps = 296/1579 (18%)

Query: 200  ETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVT 259
            ++LH+  +   H     C       RA+ +  L V   P+ +  L   +         +T
Sbjct: 1121 QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLT 1180

Query: 260  LTCQVNSSYPAVSSIKWLK--------DGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGV 311
            L C+     P   +I+W +        +   L     +L + Q    D+G+Y+C A N  
Sbjct: 1181 LLCEAMGIPPP--AIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEA 1238

Query: 312  GSLVSPPISLHIFMAEVQVSPAGP---------ILENQTVTLVCNTPNEAPSDLRYSWYK 362
            G       +   F  EV V P+           +L+ QT  L+CN        L  +W+K
Sbjct: 1239 GE------ARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFK 1290

Query: 363  NHVLLEDAHSH-------TLRLHLATRADTGFYFCEVQNVHGSE-RSGPVSVVVNHPPLT 414
            +   L    +H        L++  A  +  G Y C   N  G + +   +SV+     L 
Sbjct: 1291 DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL-----LA 1345

Query: 415  PVLTAFLETQAG---LVGI-----LHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466
            P +    E  A     V +     L C  ++ P   +     G    +    S +     
Sbjct: 1346 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEA----SRNIQLLP 1401

Query: 467  GTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA-------- 518
            GT G     L+I + ++ D+G+Y C  TN LG A    ++H     +LI P+        
Sbjct: 1402 GTHG-----LQILNAQKEDAGQYTCVVTNELGEAVK--NYH---VEVLIPPSISKDDPLG 1451

Query: 519  ------AEVVEGQAVTLSCRSGLSPTPDARFSWYLNG-------ALLHEGPGSSLLLPAA 565
                   +      +TL C S   P P  R  WY +G        L   G G  L +   
Sbjct: 1452 EVGVKEVKTKVNSTLTLECESWAVPPPTIR--WYKDGQPVTPSSRLQVLGEGRLLQIQPT 1509

Query: 566  SSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP---RQPTFTTRLDL-----DAAGAGAG 617
              +D+G Y C A +           ++ V  PP   +   F+   ++     +A G    
Sbjct: 1510 QVSDSGRYLCVATNVAGEDDQDFNVLIQV--PPMFQKVGDFSAAFEILSREEEARGGVTE 1567

Query: 618  RRGL-------LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPN 670
             R +       L C  ++ PP  L    +D+     L +G   S   G     +V + P 
Sbjct: 1568 YREIVENNPAYLYCDTNAIPPPDLTWYREDQ----PLSAGDEVSVLQG----GRVLQIP- 1618

Query: 671  LLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCN 730
            L+R        E  G Y C+ASN +G              + +  +  L E    N +  
Sbjct: 1619 LVRA-------ENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASST 1671

Query: 731  VSRE--AAGSPA-NFSWFRNGVLWAQGP----LETVTLLPVAR---TDAALYACRILTEA 780
            VS +  A G+P    SW +NG+ ++  P    LE   +L V+     DAA Y C    +A
Sbjct: 1672 VSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQA 1731

Query: 781  GAQLSTPVLLSVLYPP-----DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHL 835
            G+       L V  PP     D  +++A+L+          C V + P   +  +     
Sbjct: 1732 GS-AEKLFTLRVQVPPRIAGLDLEQVTAILNSS----VSLPCDVHAHPNPEVTWYKDSQ- 1785

Query: 836  LATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN--TSLFFQV 893
             A SLG +V             +  L++    L DSG Y CEA N  G       L   V
Sbjct: 1786 -ALSLGEEV--------FLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV 1836

Query: 894  RGAWVQVSPSPE----LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP--LQESTSA---- 943
              A+ Q    P+    ++ G   VLSC+    +PE T   WY+DGQP  L + T A    
Sbjct: 1837 PPAFRQAPRGPQDAVLVRVGDKAVLSCET-DALPEPT-VTWYKDGQPLVLAQRTQALRGG 1894

Query: 944  -TLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYA-PRHVTLTTLMDTGPGRL 1000
              L      ++  G Y C+ +   G A  +    + +  ++  P+  T++ +     G  
Sbjct: 1895 QRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQV----AGSP 1950

Query: 1001 GLLLCRVDSDPPAQLRLLHGDRL--VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAM 1058
             +L C V   P   +  L  DR+   +S + GV    G              RL++    
Sbjct: 1951 LVLTCDVSGVPAPTVTWLK-DRMPVESSAVHGVVSRGG--------------RLQLSRLQ 1995

Query: 1059 LEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGAT---------VREGQLVNLTCLV 1109
                G Y C A NT  QA A  DF    V V V P            V EGQ V L C  
Sbjct: 1996 PAQAGTYTCVAENT--QAEARKDF---VVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEA 2050

Query: 1110 WTTHPAQLTYTWYQDGQQ-----------RLDAHSIPLPNVTVRDATSYRC-GVGPPGRA 1157
                P  +   W +DG              LD  S+ L  +   DA +Y C    P G  
Sbjct: 2051 DGQPPPDV--AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 2108

Query: 1158 PRLSRPITLDVLYAP---RNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLAS 1214
             RL    T++VL  P   +    +  L S  G+L  ++C V   PP  ++    G  L  
Sbjct: 2109 ARLH---TVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL 2165

Query: 1215 STAASVPNT-LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP-----E 1268
            S    +  +   L +   Q  D G ++C A SP G A+ +  L+++ V  +L P     +
Sbjct: 2166 SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ-VPPVLEPVEFQND 2224

Query: 1269 AAVPEGAPITVTCADPAAHAPTLYTWYHNG-----RWLQEGPAASLSFLVATRAHAGAYS 1323
              V  G+ + + C       P L +W  +G     + L++GP+  L  + A    +G YS
Sbjct: 2225 VVVVRGSLVELPCEARGVPLP-LVSWMKDGEPLLSQSLEQGPSLQLEAVGA--GDSGTYS 2281

Query: 1324 CQAQDAQGTRSSRPAALQVLYAP--QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSH 1381
            C A    G  + R   L V+  P  +D+   +       +   + C     P   +    
Sbjct: 2282 CVAVSEAG-EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK 2340

Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQ 1441
            DG+ L            T     +R    L+V+D       Y C A++  G+I    R+ 
Sbjct: 2341 DGQAL------------TRLENNSRATRVLRVRDA----GLYTCLAESPAGAIEKSFRV- 2383

Query: 1442 VEGARVVAEPGLDVPEG---------AALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP 1492
                RV A P +  P G           L L C +   P P       W   D  +  E 
Sbjct: 2384 ----RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAP----KITWH-RDGIVLQED 2434

Query: 1493 VPT--------LAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLY--PPKTPTMMVFV 1542
              T        L    ++ A +G Y C A     AA S  V  RV     P   +    V
Sbjct: 2435 AHTQFPERGRFLQLQALSTADSGDYSCTAR---NAAGSTSVAFRVEIHTVPTIRSGPPAV 2491

Query: 1543 EPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEA 1602
                    +L C+ D  P A L      R+         P  P   +L    +LR  I+ 
Sbjct: 2492 NVSVNQTALLPCQADGVP-APLVSWRKDRVPLD------PRSPRFEILPE-GSLR--IQP 2541

Query: 1603 LRPSDQGEYICSASNVLGS 1621
            +   D G Y+C ASN  GS
Sbjct: 2542 VLAQDAGHYLCLASNSAGS 2560



 Score =  175 bits (444), Expect = 3e-43
 Identities = 366/1579 (23%), Positives = 562/1579 (35%), Gaps = 275/1579 (17%)

Query: 201  TLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQV--KYAPKGVKILL-----SPSGRNIL 253
            TLH+     DH  +  CQ +     A +E+ + V  ++AP  +++ +          +  
Sbjct: 553  TLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSF 612

Query: 254  PGELVTLTCQVNSSYPAVSSIK-WLKDGVRLQTKTGV---------LHLPQAAWSDAGVY 303
            P        +   ++P    ++ W   G      TG+         L + +    D G+Y
Sbjct: 613  PAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIY 672

Query: 304  TCQAENGVGSLVSPPISLHIFMAEVQVSPAG-PILENQTVTLVCNTPNEAPSDLRYSWYK 362
            TC A N  G          +    ++  P    +LEN +VTL C      P D+  SW+K
Sbjct: 673  TCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDV--SWFK 730

Query: 363  NHV-------LLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPP--- 412
             H        +        LR+  A  +D G Y C   NV GS       + VN PP   
Sbjct: 731  GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL-RYGLRVNVPPRIT 789

Query: 413  LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSG-- 470
            L P L   +     +   L C+    P  TL+    G+ ++            +GT G  
Sbjct: 790  LPPSLPGPVLVNTPV--RLTCNATGAPSPTLMWLKDGNPVSP-----------AGTPGLQ 836

Query: 471  --PNSLRLEIRDLEETDSGEYKCSATNSLGNATS--TLDFHANAARLLISPAAEVVEGQA 526
              P    L +     +DSG Y C A +++G       L  H   + L       VV  ++
Sbjct: 837  VFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANES 896

Query: 527  VTLSCRSGLSPTPDARFSWYLNGALLHEGPG-------SSLLLPAASSTDAGSYHCRA-- 577
            V L C+S   P P    SW+ +G  L   PG       + L +  A   DAG Y C A  
Sbjct: 897  VALECQSHAMPPP--VLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALN 954

Query: 578  RDGHSASGPSSPAVLTVLYPPRQP-TFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQL 636
            + G S    +    +  ++P R+  T T R          G    L C     P  ++  
Sbjct: 955  QAGRSEKHYNLNVWVAPVFPLRESHTLTVR---------EGHPTSLSCECRGVPFPKISW 1005

Query: 637  LHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG 696
                R     LP  G        +    V+    LL   +    L +EG Y CE SN +G
Sbjct: 1006 ----RKDGQPLPGEG--------AGLQHVSAVGRLL--YLGQAQLAQEGTYTCECSNVVG 1051

Query: 697  NASTSATFNGQATVLAIAPSH------TLQEGTEANLTCNVSREAAGSPANFSWFRNGV- 749
            N+S               P         +Q+G  A L CN + +    P   +W R+G  
Sbjct: 1052 NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGV-ATLECNATGK---PPPTVTWERDGQP 1107

Query: 750  ------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDR-PKLS 802
                  L  Q   +++ +          Y+C +      +      LSVL PP+    L 
Sbjct: 1108 VGAELGLQLQNQGQSLHVERAQAAHTGRYSC-VAENLAGRAERKFELSVLVPPELIGDLD 1166

Query: 803  ALLDMGQG-HMAL-FICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLK 860
             L ++    H  L  +C     P   +  F GE        P  P    +     A    
Sbjct: 1167 PLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEE-------PVSPGEDTYLL---AGGWM 1216

Query: 861  LEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPE---------LQEGQA 911
            L++ +    DSG Y C A+N  G +  +   +     V V PS E         + +GQ 
Sbjct: 1217 LKMTQTQEQDSGLYSCLASNEAGEARRNFSVE-----VLVPPSIENEDLEEVIKVLDGQT 1271

Query: 912  VVLSCQVHTGVPEGTSYRWYRDGQPLQESTS-------ATLRFAAITLTQAGAYHC-QAQ 963
              L C V TG P+     W++DG+PL    +         L+     L+ AG Y C  A 
Sbjct: 1272 AHLMCNV-TGHPQ-PKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 1329

Query: 964  APGSAT-----TSLAAPISL--HVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLR 1016
            A G  T     + L AP  L      A   VT+T            L+C   + P   + 
Sbjct: 1330 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPIS------LICEALAFPSPNI- 1382

Query: 1017 LLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQA 1076
                      T    G P  +S   ++ + P T  L+I  A  ED G Y C  +N LG+A
Sbjct: 1383 ----------TWMKDGAPFEAS--RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEA 1430

Query: 1077 ------------SASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQD 1124
                        S S D     V V+       +    + L C  W   P   T  WY+D
Sbjct: 1431 VKNYHVEVLIPPSISKDDPLGEVGVK---EVKTKVNSTLTLECESWAVPPP--TIRWYKD 1485

Query: 1125 GQ-----QRL----DAHSIPLPNVTVRDATSYRC-GVGPPG----------RAPRLSRPI 1164
            GQ      RL    +   + +    V D+  Y C      G          + P + + +
Sbjct: 1486 GQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKV 1545

Query: 1165 -----TLDVLYAPRNLR--LTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTA 1217
                   ++L      R  +T   E      A + C  ++ PP  L      + L++   
Sbjct: 1546 GDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDE 1605

Query: 1218 ASVPNTLR-LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVI------LAPEAA 1270
             SV    R L++   +  + G YSC A + +G+     EL +    VI      L  E  
Sbjct: 1606 VSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVT 1665

Query: 1271 VPEGAPITVTCADPAAHAPTLYTWYHNG---------RWLQEGPAASLSFLVATRAHAGA 1321
            V   + +++ C       PT+ +W  NG         + L++G    +S   A  A A +
Sbjct: 1666 VNASSTVSLQCPALGNPVPTI-SWLQNGLPFSPSPRLQVLEDGQVLQVS--TAEVADAAS 1722

Query: 1322 YSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV-IQCTVDSEPPAELALS 1380
            Y C A++  G+ + +   L+V   P+ A L   + +   + +V + C V + P  E+   
Sbjct: 1723 YMCVAENQAGS-AEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWY 1781

Query: 1381 HDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRL 1440
             D + L+    V  L  GT  +Q+ R  L        +    Y C A N  G    + +L
Sbjct: 1782 KDSQALSLGEEVF-LLPGTHTLQLGRARL--------SDSGMYTCEALNAAGRDQKLVQL 1832

Query: 1441 QV------EGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRL----HA 1490
             V        A    +  + V  G    LSC     P P    T  W+ + + L      
Sbjct: 1833 SVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEP----TVTWYKDGQPLVLAQRT 1888

Query: 1491 EPVPTLAFTHVARAQA---GMYHCLAELPTGAAASAPVMLRVLYP----PKTPTMMVFVE 1543
            + +       +  AQ    G+Y C      G A     +   + P    PKT T    V 
Sbjct: 1889 QALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTET----VS 1944

Query: 1544 PEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEAL 1603
               G   +L C V   P  ++T       V SS          +H + S    R+ +  L
Sbjct: 1945 QVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSA---------VHGVVSRGG-RLQLSRL 1994

Query: 1604 RPSDQGEYICSASNVLGSA 1622
            +P+  G Y C A N    A
Sbjct: 1995 QPAQAGTYTCVAENTQAEA 2013



 Score =  156 bits (395), Expect = 1e-37
 Identities = 304/1275 (23%), Positives = 456/1275 (35%), Gaps = 220/1275 (17%)

Query: 476  LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE-----------G 524
            L +  +   DSG+Y+C ATN +G+        +  A+L++     + E           G
Sbjct: 59   LFLASVSPADSGDYECQATNEVGST-------SRRAKLVVYVPPSIREDGRKANVSGMAG 111

Query: 525  QAVTLSCRSGLSPTPD----------------ARFSWYLNGA------LLHEGPGSSLLL 562
            Q++TL C +   P P+                A + W L         LL E  G SL  
Sbjct: 112  QSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDE--GQSLHF 169

Query: 563  PAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLL 622
            P      +G    +A        P    +      P    F+        GAGA +  L 
Sbjct: 170  PRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLG 229

Query: 623  LCRVD-------SDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVE 675
            L   D       S  P       KDR     LP G          P ++V +   +LR  
Sbjct: 230  LAGADVELQCWTSGVPTPQVEWTKDR--QPVLPGG----------PHLQVQEDGQVLR-- 275

Query: 676  IHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREA 735
            I    + +EG Y C A +  G  +        A       + T +     +    +  EA
Sbjct: 276  ITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEA 335

Query: 736  AGSPA-NFSWFRNG--------VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLST 786
             G P  N +WF++G        V++ +G  + + L     +DA +Y C+     GA    
Sbjct: 336  RGVPTPNITWFKDGALLPTSTKVVYTRGGRQ-LQLGRAQSSDAGVYTCKASNAVGA-AEK 393

Query: 787  PVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPS 846
               L V  PP           G G     +  V  RP+AL  +  G         P +  
Sbjct: 394  ATRLDVYVPPTIE--------GAGGRPYVVKAVAGRPVALECVARGHP------SPTLSW 439

Query: 847  HGRFQAKAEANSLKLE-------VRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQ 899
            H      AE+N  +LE       +   G   SG Y C A++  G +   L + V    VQ
Sbjct: 440  HHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA--VLQYSVE---VQ 494

Query: 900  VSPSPELQE---------GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQE-------STSA 943
            V P   + E         GQ + L CQ  +G P  T  +W ++G+P +E       S   
Sbjct: 495  VPPQLLVAEGLGQVTTIVGQPLELPCQA-SGSPVPT-IQWLQNGRPAEELAGVQVASQGT 552

Query: 944  TLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLL 1003
            TL    + L  +G + CQA    + T      +S+H  +AP  V    +     G     
Sbjct: 553  TLHIDHVELDHSGLFACQA-TNEAGTAGAEVEVSVHGEWAP-GVLEVPIGQYHWGXEHHS 610

Query: 1004 LCRVDSDPPAQLRL-LHGDRLVASTLQGVGGPEGSSPRLHVAVA-PNTLRLEIHGAMLED 1061
                  DPP       H    +       G   G    + VA + P  L++E     L D
Sbjct: 611  SFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIE--KVDLRD 668

Query: 1062 EGVYICEASNTLGQASASADFDAQA-VNVQVWP-GATVREGQLVNLTCLVWTTHPAQLTY 1119
            EG+Y C A+N  G++            N++  P    V E   V L CL     P  +  
Sbjct: 669  EGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDV-- 726

Query: 1120 TWYQDGQQ---------RLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV-- 1168
            +W++  Q           +D   + +    + DA SYRC       +  L   + ++V  
Sbjct: 727  SWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPP 786

Query: 1169 -LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASV---PNTL 1224
             +  P +L    L+ +       + C     P   L     G  ++ +    +   P   
Sbjct: 787  RITLPPSLPGPVLVNTP----VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGR 842

Query: 1225 RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPE--AAVPEGAPITVTCA 1282
             L L   +  D G YSC A S +G+    + L++     IL  E   +V     + + C 
Sbjct: 843  VLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQ 902

Query: 1283 DPAAHAPTLYTWYHNGRWLQEGPAASLS----FLVATRA---HAGAYSCQAQDAQGTRSS 1335
              A   P L +W+ +GR L+  P   LS     L   RA    AG Y+C+A +  G RS 
Sbjct: 903  SHAMPPPVL-SWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAG-RSE 960

Query: 1336 RPAALQVLYAP----QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSG 1391
            +   L V  AP    +++   + R+    S++   C     P  +++   DG+ L     
Sbjct: 961  KHYNLNVWVAPVFPLRESHTLTVREGHPTSLS---CECRGVPFPKISWRKDGQPLPGE-- 1015

Query: 1392 VHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEP 1451
                 +G  HV      L L  Q   A + TY C   N++G+ S   +L+V     +A P
Sbjct: 1016 ----GAGLQHVSAVGRLLYLG-QAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGP 1070

Query: 1452 -----GLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTL----AFTHVA 1502
                  + V +     L C   G P P    T  W  + + + AE    L       HV 
Sbjct: 1071 REPPTQVSVVQDGVATLECNATGKPPP----TVTWERDGQPVGAELGLQLQNQGQSLHVE 1126

Query: 1503 RAQA---GMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSE 1559
            RAQA   G Y C+AE   G  A     L VL PP+             L G LD      
Sbjct: 1127 RAQAAHTGRYSCVAENLAG-RAERKFELSVLVPPE-------------LIGDLD------ 1166

Query: 1560 PLASLTLHLGSRLVASSQPQG------------APAEPHIHVLASPNALRVDIEALRPSD 1607
            PL ++T  L S L    +  G             P  P            + +   +  D
Sbjct: 1167 PLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQD 1226

Query: 1608 QGEYICSASNVLGSA 1622
             G Y C ASN  G A
Sbjct: 1227 SGLYSCLASNEAGEA 1241



 Score =  152 bits (385), Expect = 2e-36
 Identities = 358/1572 (22%), Positives = 539/1572 (34%), Gaps = 279/1572 (17%)

Query: 210  DHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYP 269
            D GR      S A  +A+ +  L+V +AP  +          ++   LV L C+      
Sbjct: 283  DEGRYQCVAFSPAGQQAR-DFQLRV-HAPPTIWGSNETGEVAVMEDHLVQLLCEARGV-- 338

Query: 270  AVSSIKWLKDGVRLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISL 321
               +I W KDG  L T T V        L L +A  SDAGVYTC+A N VG+       L
Sbjct: 339  PTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA-AEKATRL 397

Query: 322  HIFMAEVQVSPAG-----PILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH----- 371
             +++        G       +  + V L C         L  SW+   + + +++     
Sbjct: 398  DVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL--SWHHEGLPVAESNESRLE 455

Query: 372  --SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF--LETQAGL 427
                 LRL     A +G Y C   +  G E     SV V  PP   V      + T  G 
Sbjct: 456  TDGSVLRLESPGEASSGLYSCVASSPAG-EAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQ 514

Query: 428  VGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
               L C     P+ T+     G      +G    S    GT+      L I  +E   SG
Sbjct: 515  PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVAS---QGTT------LHIDHVELDHSG 565

Query: 488  EYKCSATNSLGNATSTLDFHAN---AARLLISPAAEVVEG----QAVTLSCRS------G 534
             + C ATN  G A + ++   +   A  +L  P  +   G     +   +C        G
Sbjct: 566  LFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWG 625

Query: 535  LSPTPDARFSWYLNGALLHEGPG--------SSLLLPAASSTDAGSYHCRARDGHSASGP 586
              P P     W   G+L  E  G          L +      D G Y C A   + A   
Sbjct: 626  AHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT--NLAGES 683

Query: 587  SSPAVLTVLYPPR-QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVAT 645
                 L VL PP  +P    +  L+ A         L C     PP  +      + V  
Sbjct: 684  KREVALKVLVPPNIEPGPVNKAVLENASV------TLECLASGVPPPDVSWFKGHQPV-- 735

Query: 646  SLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFN 705
                          S  M VT + +   + I    L + G Y C ASN  G  ST   + 
Sbjct: 736  --------------SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG--STELRYG 779

Query: 706  GQATV---LAIAPS--HTLQEGTEANLTCNVSREAAGSPA-NFSWFRNG--VLWAQGP-- 755
             +  V   + + PS    +   T   LTCN    A G+P+    W ++G  V  A  P  
Sbjct: 780  LRVNVPPRITLPPSLPGPVLVNTPVRLTCN----ATGAPSPTLMWLKDGNPVSPAGTPGL 835

Query: 756  -----LETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQG 810
                    +TL     +D+  Y+C  ++  G      V+L V  PP        + +   
Sbjct: 836  QVFPGGRVLTLASARASDSGRYSCVAVSAVGED-RQDVVLQVHMPPSILGEELNVSVVAN 894

Query: 811  HMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGD 870
                  C   + P  +L+ +              P   R      A+   L+V    + D
Sbjct: 895  ESVALECQSHAMPPPVLSWWKDGR----------PLEPRPGVHLSADKALLQVDRADVWD 944

Query: 871  SGSYRCEATNVLGSSNTSLFFQVRGAWV------QVSPSPELQEGQAVVLSCQVHTGVPE 924
            +G Y CEA N  G S       V   WV      + S +  ++EG    LSC+   GVP 
Sbjct: 945  AGHYTCEALNQAGRSEKHYNLNV---WVAPVFPLRESHTLTVREGHPTSLSCECR-GVP- 999

Query: 925  GTSYRWYRDGQPLQESTSATLRFAAI---------TLTQAGAYHCQ-AQAPGSATTSLAA 974
                 W +DGQPL    +     +A+          L Q G Y C+ +   G+++  L  
Sbjct: 1000 FPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQL 1059

Query: 975  PISLHVSYA-PRH-VTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVG 1032
             + +    A PR   T  +++  G   +  L C     PP  +           T +  G
Sbjct: 1060 EVHVPPQIAGPREPPTQVSVVQDG---VATLECNATGKPPPTV-----------TWERDG 1105

Query: 1033 GPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVW 1092
             P G+   L +     +L +E   A     G Y C A N  G+A    +     ++V V 
Sbjct: 1106 QPVGAELGLQLQNQGQSLHVE--RAQAAHTGRYSCVAENLAGRAERKFE-----LSVLVP 1158

Query: 1093 PGATVREGQLVNLTCLVWTTHPAQL----------TYTWY---------QDGQQRLDAHS 1133
            P        L N+T  + +  P  L             W+         +D         
Sbjct: 1159 PELIGDLDPLTNITAALHS--PLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM 1216

Query: 1134 IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAP--RNLRLTYLLESHGGQLALV 1191
            + +     +D+  Y C       A    R  +++VL  P   N  L  +++   GQ A +
Sbjct: 1217 LKMTQTQEQDSGLYSCLAS--NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHL 1274

Query: 1192 LCTVDSRPPAQLALSHAGRLLASSTAASV-PNTLRLELRGPQPRDEGFYSCSARSPLGQA 1250
            +C V   P  +L     GR LA   A  + P+ + L++        G YSC A + +G+ 
Sbjct: 1275 MCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEK 1334

Query: 1251 NTSLELRLEGVRVILAP------------EAAVPEGAPITVTCADPAAHAPTLYTWYHNG 1298
                +L      V+LAP            E  V    PI++ C   A  +P + TW  +G
Sbjct: 1335 TKHFQL-----SVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNI-TWMKDG 1388

Query: 1299 ------RWLQEGPAA-SLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP---QD 1348
                  R +Q  P    L  L A +  AG Y+C   +  G  + +   ++VL  P   +D
Sbjct: 1389 APFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG-EAVKNYHVEVLIPPSISKD 1447

Query: 1349 AVLSSFR----DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQV 1404
              L         ++  S   ++C   + PP  +    DG+ +  SS +  L  G      
Sbjct: 1448 DPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR----- 1502

Query: 1405 ARNALRLQVQDVPAGDD-TYVCTAQNLLGS--------------ISTIGRLQV------- 1442
                  LQ+Q     D   Y+C A N+ G                  +G           
Sbjct: 1503 -----LLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSR 1557

Query: 1443 -EGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA-------EPVP 1494
             E AR       ++ E     L C     P P       W+  D+ L A       +   
Sbjct: 1558 EEEARGGVTEYREIVENNPAYLYCDTNAIPPP----DLTWYREDQPLSAGDEVSVLQGGR 1613

Query: 1495 TLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPP----KTPTMMVFVEPEGGLRG 1550
             L    V    AG Y C A    G       +L VL PP     T  ++  V        
Sbjct: 1614 VLQIPLVRAENAGRYSCKASNEVGEDWLHYELL-VLTPPVILGDTEELVEEVTVNASSTV 1672

Query: 1551 ILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGE 1610
             L C     P+ ++          S    G P  P   +    +   + +     +D   
Sbjct: 1673 SLQCPALGNPVPTI----------SWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAAS 1722

Query: 1611 YICSASNVLGSA 1622
            Y+C A N  GSA
Sbjct: 1723 YMCVAENQAGSA 1734



 Score =  148 bits (374), Expect = 4e-35
 Identities = 309/1299 (23%), Positives = 445/1299 (34%), Gaps = 234/1299 (18%)

Query: 251  NILPGELVTLTCQVNSSYPAVSSIKWLKDG----------VRLQTKTGVLHLPQAAWSDA 300
            ++L G+ V L C+ +   P    + WLKDG          +R     G L L     SDA
Sbjct: 2037 HVLEGQEVRLDCEADGQPPP--DVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA 2094

Query: 301  GVYTCQAENGVGS---------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNE 351
            G YTC A N  G          LV P I      +   VS  G +     VT+VC     
Sbjct: 2095 GAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGEL-----VTMVCPVRGS 2149

Query: 352  APSDLRYSWYKNHVLLE-------DAHSHTLRLHLATRADTGFYFCEVQNVHG-SERSGP 403
             P  +  SW K+ + L            HTLR+     AD G + C   +  G ++R+  
Sbjct: 2150 PP--IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFT 2207

Query: 404  VSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP 463
            + V V  P L PV     E Q  +V      VV   L  L     G  L   S   D  P
Sbjct: 2208 LQVQVP-PVLEPV-----EFQNDVV------VVRGSLVELPCEARGVPLPLVSWMKDGEP 2255

Query: 464  RFSGT--SGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEV 521
              S +   GP+   L++  +   DSG Y C A +  G A             ++ P    
Sbjct: 2256 LLSQSLEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQL------TVMEPPHIE 2306

Query: 522  VEGQAVTLSCRSGL--------SPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSY 573
              GQ   LS   G           TP    +W+ +G  L     +S         DAG Y
Sbjct: 2307 DSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLY 2366

Query: 574  HCRARDGHSASGPSSPAVLTV---LYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDP 630
             C A     A   S    +     +  PR P F   L        A  + +L C V+++P
Sbjct: 2367 TCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGL--------APGQLVLECSVEAEP 2418

Query: 631  PARLQLLHKDRVVA-----TSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685
              ++   H+D +V      T  P  G                      +++      + G
Sbjct: 2419 APKITW-HRDGIVLQEDAHTQFPERGRF--------------------LQLQALSTADSG 2457

Query: 686  LYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANF-SW 744
             Y C A NA G  STS  F  +   +    S         N T  +  +A G PA   SW
Sbjct: 2458 DYSCTARNAAG--STSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSW 2515

Query: 745  FRNGV-------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPD 797
             ++ V        +   P  ++ + PV   DA  Y C     AG+      L  VL PP 
Sbjct: 2516 RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDL-RVLEPPA 2574

Query: 798  RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEAN 857
                 + L +     AL  C     P  L+  +     L   L       G ++    +N
Sbjct: 2575 IAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL-----QQGAYRL-LPSN 2628

Query: 858  SLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQA------ 911
            +L L     G  DS  + C  +N +G ++       R   V V   P + + Q       
Sbjct: 2629 ALLLTAP--GPQDSAQFECVVSNEVGEAH-------RLYQVTVHVPPTIADDQTDFTVTM 2679

Query: 912  ---VVLSCQVHTGVPEGTSYRWYRDGQPL-------QESTSATLRFAAITLTQAGAYHCQ 961
               VVL+C   TG+P  T   W + G  L       + S S  L         AG Y C 
Sbjct: 2680 MAPVVLTCH-STGIPAPT-VSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCS 2737

Query: 962  AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGD 1021
            A+            + L V  +P    L +++        LL C     P   +      
Sbjct: 2738 ARNSAGVAHK---HVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG 2794

Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081
              VA+ +     P G              +L I  A  ED G Y+C A N+ G A     
Sbjct: 2795 LNVATGVSTQVLPGG--------------QLRIAHASPEDAGNYLCIAKNSAGSAMGKTR 2840

Query: 1082 FDAQAVNV--QVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS------ 1133
               Q   V     P  +  EG    L C    +    +T  W +DGQ    A        
Sbjct: 2841 LVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNIT--WDKDGQPVSGAEGKFTIQP 2898

Query: 1134 ---IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAP--------RNLRLTYLL- 1181
               + + N+  +DA +Y C         R  R + L +L  P        R+LRL   L 
Sbjct: 2899 SGELLVKNLEGQDAGTYTCTA--ENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLW 2956

Query: 1182 ---ESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGF 1238
                + G     +  TV+ RP  +      G       A S               D G 
Sbjct: 2957 LRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVS-------------REDSGT 3003

Query: 1239 YSCSARSPLGQANTSLELRLEGVRVILAPEAAV---PEGAPITVTCADPAAHAPTLYTWY 1295
            Y C A + +G+      + ++   V+     +    P G  I + C       P ++ W 
Sbjct: 3004 YVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIH-WI 3062

Query: 1296 HNG---------RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP 1346
             +G           LQ G   SL+     R  AG Y C A++  G  + +   L +  AP
Sbjct: 3063 KDGLPLRGSHLRHQLQNG---SLTIHRTERDDAGRYQCLAENEMGV-AKKVVILVLQSAP 3118

Query: 1347 QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVAR 1406
               V       R+     ++C    EP   +     G+ L  S  + +L  G+       
Sbjct: 3119 VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGS------- 3171

Query: 1407 NALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQVEG 1444
                L +++V  GD  TY C A NLLGS +    L V G
Sbjct: 3172 ----LWLENVETGDAGTYDCVAHNLLGSATARAFLVVRG 3206



 Score =  144 bits (362), Expect = 1e-33
 Identities = 356/1523 (23%), Positives = 529/1523 (34%), Gaps = 293/1523 (19%)

Query: 250  RNILPGELVTLTCQVNSSYPAVSSIKWLK--------DGVRLQTKTGVLHLPQAAWSDAG 301
            R I+      L C  N+  P    + W +        D V +     VL +P     +AG
Sbjct: 1569 REIVENNPAYLYCDTNAIPPP--DLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAG 1626

Query: 302  VYTCQAENGVGS--------LVSPPISL---HIFMAEVQVSPAGPILENQTVTLVCNT-P 349
             Y+C+A N VG         +++PP+ L      + EV V+ +       TV+L C    
Sbjct: 1627 RYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS------TVSLQCPALG 1680

Query: 350  NEAPSDLRYSWYKNHV---------LLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSER 400
            N  P+    SW +N +         +LED     L++  A  AD   Y C  +N  GS  
Sbjct: 1681 NPVPT---ISWLQNGLPFSPSPRLQVLEDGQ--VLQVSTAEVADAASYMCVAENQAGSAE 1735

Query: 401  SGPVSVVVNHPPLTPVL-----TAFLETQAGLVGILHCSVVSEPL---ATLVLSHGGHIL 452
                ++ V  PP    L     TA L +   L   +H     E      +  LS G  + 
Sbjct: 1736 K-LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVF 1794

Query: 453  ASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR 512
                              P +  L++     +DSG Y C A N+ G     +        
Sbjct: 1795 LL----------------PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLS----- 1833

Query: 513  LLISPAAE-----------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP----- 556
            +L+ PA             V  G    LSC +   P P    +WY +G  L         
Sbjct: 1834 VLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTV--TWYKDGQPLVLAQRTQAL 1891

Query: 557  --GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGA 614
              G  L +  A  +D G Y C+    + A        LTV  PP      T      AG+
Sbjct: 1892 RGGQRLEIQEAQVSDKGLYSCKV--SNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGS 1949

Query: 615  GAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRV 674
                  +L C V   P   +  L KDR+   S    G  S  G               R+
Sbjct: 1950 PL----VLTCDVSGVPAPTVTWL-KDRMPVESSAVHGVVSRGG---------------RL 1989

Query: 675  EIHNPLLEEEGLYLCEASNALGNAS----TSATFNGQATVLAIAPSHTLQEGTEANLTCN 730
            ++      + G Y C A N    A      +     +     +A  H + EG E  L C 
Sbjct: 1990 QLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC- 2048

Query: 731  VSREAAGSPA-NFSWFRNGVLWAQ--GPL-------ETVTLLPVARTDAALYACRILTEA 780
               EA G P  + +W ++G    Q  GP         ++ L  +  +DA  Y C     A
Sbjct: 2049 ---EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPA 2105

Query: 781  G--AQLSTPVLLSVLYPPDRPKL---SALLDMGQGHMALFICTV-DSRPLALLALFHGEH 834
            G  A+L T   ++VL PP   +    S  L    G +   +C V  S P+ +  L  G  
Sbjct: 2106 GEDARLHT---VNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDG-- 2160

Query: 835  LLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894
             L   L  +   HG        +   L + ++ L D+G + C A +  G ++ +   QV 
Sbjct: 2161 -LPLPLSQRTLLHG--------SGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV- 2210

Query: 895  GAWVQVSPSPELQE---------GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST---S 942
                QV P  E  E         G  V L C+   GVP      W +DG+PL   +    
Sbjct: 2211 ----QVPPVLEPVEFQNDVVVVRGSLVELPCEAR-GVPLPL-VSWMKDGEPLLSQSLEQG 2264

Query: 943  ATLRFAAITLTQAGAYHCQA-----QAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP 997
             +L+  A+    +G Y C A     +A      ++  P  +  S  P  ++LT      P
Sbjct: 2265 PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLT------P 2318

Query: 998  GRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGA 1057
            G    LLC     P   +   H D    + L+            + + A   LR+     
Sbjct: 2319 GAPMELLCDAQGTPQPNITW-HKDGQALTRLE------------NNSRATRVLRVR---- 2361

Query: 1058 MLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGAT-----VREGQLVNLTCLVWTT 1112
               D G+Y C A +  G    S     QA    V P        +  GQLV L C V   
Sbjct: 2362 ---DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSV-EA 2416

Query: 1113 HPAQLTYTWYQDG-QQRLDAHS--------IPLPNVTVRDATSYRC----GVGPPGRAPR 1159
             PA    TW++DG   + DAH+        + L  ++  D+  Y C      G    A R
Sbjct: 2417 EPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2475

Query: 1160 LSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGR--LLASSTA 1217
            +       +   P  + ++        Q AL+ C  D   PA L      R  L   S  
Sbjct: 2476 VEIHTVPTIRSGPPAVNVSV------NQTALLPCQADG-VPAPLVSWRKDRVPLDPRSPR 2528

Query: 1218 ASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPI 1277
              +     L ++    +D G Y C A +  G      +LR      +L P A  P  + +
Sbjct: 2529 FEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR------VLEPPAIAPSPSNL 2582

Query: 1278 TVTCADPA-------AHAPTLYTWYHNGRWL----QEG-----PAASLSFLVATRAHAGA 1321
            T+T   PA            L  W+ +G+ L    Q+G     P+ +L         +  
Sbjct: 2583 TLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQ 2642

Query: 1322 YSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMA--VIQCTVDSEPPAELAL 1379
            + C   +  G         QV       +     D     MA  V+ C     P   ++ 
Sbjct: 2643 FECVVSNEVGEAHR---LYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSW 2699

Query: 1380 SHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGR 1439
            S  G  L         A G+G+      AL +  Q +P     Y C+A+N  G       
Sbjct: 2700 SKAGAQLG--------ARGSGYRVSPSGALEIG-QALPIHAGRYTCSARNSAGVAHKHVF 2750

Query: 1440 LQVEGARVVAEPGLDVPEGAA---LNLSCRLLGGPGPVGNSTFAWFWNDRRL------HA 1490
            L V+ + VV +P   V    A   + L C   G P P    T  W      +        
Sbjct: 2751 LTVQASPVV-KPLPSVVRAVAEEEVLLPCEASGIPRP----TITWQKEGLNVATGVSTQV 2805

Query: 1491 EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRG 1550
             P   L   H +   AG Y C+A+   G+A      L V  PP     +  +    G   
Sbjct: 2806 LPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGK-TRLVVQVPPVIENGLPDLSTTEGSHA 2864

Query: 1551 ILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGE 1610
             L C+    P  ++T     + V+        AE    +  S   L   ++ L   D G 
Sbjct: 2865 FLPCKARGSPEPNITWDKDGQPVSG-------AEGKFTIQPSGELL---VKNLEGQDAGT 2914

Query: 1611 YICSASNVLGSASTSTYFGVRAL 1633
            Y C+A N +G A    +  +  L
Sbjct: 2915 YTCTAENAVGRARRRVHLTILVL 2937



 Score =  124 bits (311), Expect = 8e-28
 Identities = 263/1141 (23%), Positives = 402/1141 (35%), Gaps = 168/1141 (14%)

Query: 188  SQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSP 247
            SQ+    G GH  TL ++        I  C  +     A     LQV+  P    +L   
Sbjct: 2166 SQRTLLHGSGH--TLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPP----VLEPV 2219

Query: 248  SGRN---ILPGELVTLTCQVNS-SYPAVSSIKWLKDGVRLQTKT----GVLHLPQAAWSD 299
              +N   ++ G LV L C+      P VS   W+KDG  L +++      L L      D
Sbjct: 2220 EFQNDVVVVRGSLVELPCEARGVPLPLVS---WMKDGEPLLSQSLEQGPSLQLEAVGAGD 2276

Query: 300  AGVYTCQAENGVG--------SLVSPPISLHIFMA----EVQVSPAGPILENQTVTLVCN 347
            +G Y+C A +  G        +++ PP   HI  +    E+ ++P  P+       L+C+
Sbjct: 2277 SGTYSCVAVSEAGEARRHFQLTVMEPP---HIEDSGQPTELSLTPGAPM------ELLCD 2327

Query: 348  TPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGS-ERSGPVSV 406
                   ++  +W+K+   L    +++    +    D G Y C  ++  G+ E+S  V V
Sbjct: 2328 AQGTPQPNI--TWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRV 2385

Query: 407  VVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466
                  + P    F+   A    +L CSV +EP   +     G +L   +          
Sbjct: 2386 QAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAH--------- 2436

Query: 467  GTSGPNSLR-LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLIS--PAAEVVE 523
             T  P   R L+++ L   DSG+Y C+A N+ G+ +       +    + S  PA  V  
Sbjct: 2437 -TQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSV 2495

Query: 524  GQAVTLSCRSGLSPTPDARFSWYLNGALLHEG-------PGSSLLLPAASSTDAGSYHCR 576
             Q   L C++   P P    SW  +   L          P  SL +    + DAG Y C 
Sbjct: 2496 NQTALLPCQADGVPAP--LVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCL 2553

Query: 577  ARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQL 636
            A   +SA        L VL PP      + L L A         LL C     P   +  
Sbjct: 2554 A--SNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPA-----LLPCEASGSPKPLVVW 2606

Query: 637  LHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG 696
                + +   L  G             ++  +  LL   +  P  ++   + C  SN +G
Sbjct: 2607 WKDGQKLDFRLQQGA-----------YRLLPSNALL---LTAPGPQDSAQFECVVSNEVG 2652

Query: 697  NAST--SATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNGV---- 749
             A      T +   T+       T+       LTC+    + G PA   SW + G     
Sbjct: 2653 EAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCH----STGIPAPTVSWSKAGAQLGA 2708

Query: 750  ------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSA 803
                  +   G LE    LP+    A  Y C     AG      V L+V   P    L +
Sbjct: 2709 RGSGYRVSPSGALEIGQALPI---HAGRYTCSARNSAGVA-HKHVFLTVQASPVVKPLPS 2764

Query: 804  LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
            ++        L  C     P   +        +AT +  QV   G+           L +
Sbjct: 2765 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ-----------LRI 2813

Query: 864  RELGLGDSGSYRCEATNVLGSS--NTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTG 921
                  D+G+Y C A N  GS+   T L  QV        P     EG    L C+   G
Sbjct: 2814 AHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKAR-G 2872

Query: 922  VPEGTSYRWYRDGQPLQEST-------SATLRFAAITLTQAGAYHCQAQAPGSATTSLAA 974
             PE  +  W +DGQP+  +        S  L    +    AG Y C A+   +A      
Sbjct: 2873 SPE-PNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAE---NAVGRARR 2928

Query: 975  PISLHVSYAPRHVTLTTLMDTGPGRLG---LLLCRVDSDPPAQLRLLHGDRLVASTLQGV 1031
             + L +   P     TTL      RLG    L C     P  ++     DR V    +GV
Sbjct: 2929 RVHLTILVLP---VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT---EGV 2982

Query: 1032 GGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF---DAQAVN 1088
               +G S     AV+             ED G Y+C A N +G+  A +     +A  + 
Sbjct: 2983 SEQDGGSTLQRAAVSR------------EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQ 3030

Query: 1089 VQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDG--------QQRLDAHSIPLPNVT 1140
             + +       G  + L C+V       +   W +DG        + +L   S+ +    
Sbjct: 3031 GEAFSYLVEPVGGSIQLDCVVRGDPVPDIH--WIKDGLPLRGSHLRHQLQNGSLTIHRTE 3088

Query: 1141 VRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRP 1199
              DA  Y+C      G A ++   + L +  AP        +    G    + C     P
Sbjct: 3089 RDDAGRYQCLAENEMGVAKKV---VILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEP 3145

Query: 1200 PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE 1259
               +    AG+ L +S          L L   +  D G Y C A + LG A     L + 
Sbjct: 3146 TPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3205

Query: 1260 G 1260
            G
Sbjct: 3206 G 3206



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 192/856 (22%), Positives = 301/856 (35%), Gaps = 132/856 (15%)

Query: 842  PQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGA---W- 897
            P +P     Q + +   L++    +G  D G Y+C A +  G        +V      W 
Sbjct: 257  PVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSPAGQQARDFQLRVHAPPTIWG 314

Query: 898  VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT-------LRFAAI 950
               +    + E   V L C+   GVP   +  W++DG  L  ST          L+    
Sbjct: 315  SNETGEVAVMEDHLVQLLCEAR-GVPT-PNITWFKDGALLPTSTKVVYTRGGRQLQLGRA 372

Query: 951  TLTQAGAYHCQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDS 1009
              + AG Y C+A  A G+A  +    +     Y P  +        G G    ++  V  
Sbjct: 373  QSSDAGVYTCKASNAVGAAEKATRLDV-----YVPPTIE-------GAGGRPYVVKAVAG 420

Query: 1010 DPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA 1069
             P A   +  G      +    G P   S    +    + LRLE  G      G+Y C A
Sbjct: 421  RPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEA--SSGLYSCVA 478

Query: 1070 SNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQL----------TY 1119
            S+  G+A         +V VQV P   V EG L  +T +V    P +L          T 
Sbjct: 479  SSPAGEAVLQ-----YSVEVQVPPQLLVAEG-LGQVTTIVG--QPLELPCQASGSPVPTI 530

Query: 1120 TWYQDG---------QQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLY 1170
             W Q+G         Q      ++ + +V +  +  + C              +++   +
Sbjct: 531  QWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEW 590

Query: 1171 APRNLRLT-----YLLESHGGQLALVLCTVDS------RPPAQLALSHAGRLLASSTAAS 1219
            AP  L +      +  E H    A     V        +PP        G L    T   
Sbjct: 591  APGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIP 650

Query: 1220 VPNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEA-------A 1270
            V  +L   L++     RDEG Y+C+A +  G++   + L+     V++ P         A
Sbjct: 651  VAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALK-----VLVPPNIEPGPVNKA 705

Query: 1271 VPEGAPITVTCADPAAHAPTLYTWYHNGR----WLQEGPAASLSFLV-----ATRAHAGA 1321
            V E A +T+ C       P + +W+   +    W+  G   S+   V     A  + AG+
Sbjct: 706  VLENASVTLECLASGVPPPDV-SWFKGHQPVSSWM--GVTVSVDGRVLRIEQAQLSDAGS 762

Query: 1322 YSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV-IQCTVDSEPPAELALS 1380
            Y C A +  G+   R   L+V   P+  +  S       +  V + C     P   L   
Sbjct: 763  YRCVASNVAGSTELR-YGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWL 821

Query: 1381 HDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGR 1439
             DG  ++ +        GT  +QV      L +    A D   Y C A + +G       
Sbjct: 822  KDGNPVSPA--------GTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV 873

Query: 1440 LQVEGARVVA--EPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTL- 1496
            LQV     +   E  + V    ++ L C+    P PV     +W+ + R L   P   L 
Sbjct: 874  LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV----LSWWKDGRPLEPRPGVHLS 929

Query: 1497 ---AFTHVARAQ---AGMYHCLAELPTGAAA---SAPVMLRVLYPPKTPTMMVFVEPEGG 1547
               A   V RA    AG Y C A    G +    +  V +  ++P +    +   E   G
Sbjct: 930  ADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVRE---G 986

Query: 1548 LRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSD 1607
                L C     P   ++           QP         HV A    L +    L  + 
Sbjct: 987  HPTSLSCECRGVPFPKISWR------KDGQPLPGEGAGLQHVSAVGRLLYLGQAQL--AQ 1038

Query: 1608 QGEYICSASNVLGSAS 1623
            +G Y C  SNV+G++S
Sbjct: 1039 EGTYTCECSNVVGNSS 1054



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 141/589 (23%), Positives = 199/589 (33%), Gaps = 96/589 (16%)

Query: 1100 GQLVNLTCLVWTTHPAQLTYTWYQDGQQRL----------DAHSIPLPNVTVRDATSYRC 1149
            G  V L C  WT+        W +D Q  L          D   + +    V D   Y+C
Sbjct: 232  GADVELQC--WTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQC 289

Query: 1150 GVGPPGRAPRLSRPITLDV-----LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLA 1204
                P  A + +R   L V     ++         ++E H   L  +LC     P   + 
Sbjct: 290  VAFSP--AGQQARDFQLRVHAPPTIWGSNETGEVAVMEDH---LVQLLCEARGVPTPNIT 344

Query: 1205 LSHAGRLLASSTAASVPNTLR-LELRGPQPRDEGFYSCSARSPLGQANTSLELRL----- 1258
                G LL +ST        R L+L   Q  D G Y+C A + +G A  +  L +     
Sbjct: 345  WFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT 404

Query: 1259 ---EGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVAT 1315
                G R  +    A   G P+ + C      +PTL +W+H G  + E   + L    + 
Sbjct: 405  IEGAGGRPYVVKAVA---GRPVALECVARGHPSPTL-SWHHEGLPVAESNESRLETDGSV 460

Query: 1316 -------RAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCT 1368
                    A +G YSC A    G  +    +++V   PQ  V               Q T
Sbjct: 461  LRLESPGEASSGLYSCVASSPAG-EAVLQYSVEVQVPPQLLVAEGLG----------QVT 509

Query: 1369 VDSEPPAELALSHDGKVLATSSGVHS--LASGTGHVQVARNALRLQVQDVPAGDD-TYVC 1425
                 P EL     G  + T   + +   A     VQVA     L +  V       + C
Sbjct: 510  TIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFAC 569

Query: 1426 TAQNLLGSISTIGRLQVEGARVVAEPG-LDVPEG-------------AALNLSCRLLGGP 1471
             A N  G+      + V G      PG L+VP G             AA +       G 
Sbjct: 570  QATNEAGTAGAEVEVSVHGEWA---PGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGA 626

Query: 1472 GPVGNSTFAWFWNDRRLHAEPV---------PTLAFTHVARAQAGMYHCLAELPTGAAAS 1522
             P       W  +   L  EP          P L    V     G+Y C A    G +  
Sbjct: 627  HPKPPLVEGWC-SPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGES-K 684

Query: 1523 APVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAP 1582
              V L+VL PP      V           L+C     P   ++   G + V+S       
Sbjct: 685  REVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSS------- 737

Query: 1583 AEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
                + V  S +   + IE  + SD G Y C ASNV G  ST   +G+R
Sbjct: 738  ---WMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG--STELRYGLR 781



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 82/328 (25%), Positives = 119/328 (36%), Gaps = 37/328 (11%)

Query: 100  LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159
            LL+K+L+ +D+G+Y    E +       V  T++ +   P   T+     L  G  +   
Sbjct: 2902 LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL---PVFTTLPGDRSLRLGDRLWLR 2958

Query: 160  CSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQL 219
            C+          R+ W   D  R VT      E  G   L+    A+S +D G  + C  
Sbjct: 2959 CAARG---SPTPRIGWTVND--RPVTEGVS--EQDGGSTLQ--RAAVSREDSGTYV-CWA 3008

Query: 220  SVANHRAQSEIHLQVKYAP----KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIK 275
                 R Q+   + VK AP    +    L+ P G +I       L C V      V  I 
Sbjct: 3009 ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSI------QLDCVVRGD--PVPDIH 3060

Query: 276  WLKDGVRL-------QTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEV 328
            W+KDG+ L       Q + G L + +    DAG Y C AEN +G      I +       
Sbjct: 3061 WIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVF 3120

Query: 329  QVSPAG-PILENQTVTLVCNTPNEAPSDLRYSWYKNHVL----LEDAHSHTLRLHLATRA 383
            QV P    +     V L C    E    + +      +     L      +L L      
Sbjct: 3121 QVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETG 3180

Query: 384  DTGFYFCEVQNVHGSERSGPVSVVVNHP 411
            D G Y C   N+ GS  +    VV   P
Sbjct: 3181 DAGTYDCVAHNLLGSATARAFLVVRGEP 3208


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score =  205 bits (522), Expect = 3e-52
 Identities = 356/1491 (23%), Positives = 543/1491 (36%), Gaps = 255/1491 (17%)

Query: 259  TLTCQVNSSYPAVSSIKWLKDGV------RLQTKTG--VLHLPQAAWSDAGVYTCQAENG 310
            T++ Q  +    V +I WL++G+      RLQ      VL +  A  +DA  Y C AEN 
Sbjct: 2862 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ 2921

Query: 311  VGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLR------YSWYKNH 364
             GS         +F   VQV P    L+ + VT + N+    P D+        +WYK+ 
Sbjct: 2922 AGSAEK------LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDS 2975

Query: 365  VLLEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSERS-GPVSVVV----NHPP 412
              L           +HTL+L  A  +D+G Y CE  N  G ++    +SV+V       P
Sbjct: 2976 QALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAP 3035

Query: 413  LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPN 472
              P     +  + G   +L C   + P  T+     G  L           R     G  
Sbjct: 3036 RGPQDAVLV--RVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQ-------RTQALRGGQ 3086

Query: 473  SLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE---GQAVTL 529
              RLEI++ + +D G Y C  +N  G A  T            +P  E V    G  + L
Sbjct: 3087 --RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVL 3144

Query: 530  SCRSGLSPTPDARFSWY-----LNGALLH--EGPGSSLLLPAASSTDAGSYHCRARDGHS 582
            +C   +S  P    +W      +  + +H     G  L L       AG+Y C A +  +
Sbjct: 3145 TC--DVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA 3202

Query: 583  ASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRV 642
             +      V+ VL  PR  +     +        G+   L C  D  PP  +  L     
Sbjct: 3203 EA--RKDFVVAVLVAPRIRSSGVAREHHVL---EGQEVRLDCEADGQPPPDVAWLKDGSP 3257

Query: 643  VATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSA 702
            +   +         GG S  +K  +A              + G Y C A N  G  +   
Sbjct: 3258 LGQDMGPHLRFYLDGG-SLVLKGLRA-------------SDAGAYTCVAHNPAGEDARLH 3303

Query: 703  TFNGQATVLAIAPSHTLQEGTEAN---------LTCNVSREAAGSPANFSWFRNGV---- 749
            T N     + + P  T+++G + +         L   V       P + SW ++G+    
Sbjct: 3304 TVN-----VLVPP--TIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL 3356

Query: 750  ---LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLD 806
                   G   T+ +  V   DA ++ C   + AG        L V  PP    +    D
Sbjct: 3357 SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGV-ADRNFTLQVQVPPVLEPVEFQND 3415

Query: 807  --MGQGHMALFICTVDSRPLALLA-LFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
              + +G +    C     PL L++ +  GE LL+ SL  Q PS              L++
Sbjct: 3416 VVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSL-EQGPS--------------LQL 3460

Query: 864  RELGLGDSGSYRCEATNVLGSSNTSLFFQV-RGAWVQVSPSP---ELQEGQAVVLSCQVH 919
              +G GDSG+Y C A +  G +       V     ++ S  P    L  G  + L C   
Sbjct: 3461 EAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 3520

Query: 920  TGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSA-----TTSLAA 974
             G P+  +  W++DGQ L    + +     + +  AG Y C A++P  A        + A
Sbjct: 3521 -GTPQ-PNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQA 3578

Query: 975  PISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034
            P ++     PR V     +   PG+L +L C V+++P  ++   H D +V          
Sbjct: 3579 PPNIVGPRGPRFV-----VGLAPGQL-VLECSVEAEPAPKI-TWHRDGIVL--------- 3622

Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG 1094
                   H         L++      D G Y C A N  G  S        A  V++   
Sbjct: 3623 ---QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSV-------AFRVEIHTV 3672

Query: 1095 ATVREGQ-----LVNLTCLVWTTH---PAQLTYTWYQDGQ---------QRLDAHSIPLP 1137
             T+R G       VN T L+       PA L  +W +D           + L   S+ + 
Sbjct: 3673 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLV-SWRKDRVPLDPRSPRFEILPEGSLRIQ 3731

Query: 1138 NVTVRDATSYRC------GVGPPGRAPRLSRPITLDVLYAPRNLRLT------YLLESHG 1185
             V  +DA  Y C      G    GR  R+  P    +  +P NL LT         E+ G
Sbjct: 3732 PVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPA--IAPSPSNLTLTAHTPALLPCEASG 3789

Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARS 1245
                LV+   D +         A RLL S+          L L  P P+D   + C   +
Sbjct: 3790 SPKPLVVWWKDGQKLDFRLQQGAYRLLPSNA---------LLLTAPGPQDSAQFECVVSN 3840

Query: 1246 PLGQANTSLELRLEGVRVILAPEAA-------VPEGAPITVTCADPAAHAPTLYTWYHNG 1298
             +G+A+     RL  V V + P  A       V   AP+ +TC      APT+ +W   G
Sbjct: 3841 EVGEAH-----RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTV-SWSKAG 3894

Query: 1299 RWL-------QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVL 1351
              L       +  P+ +L    A   HAG Y+C A+++ G  + +   L V  +P    L
Sbjct: 3895 AQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPL 3953

Query: 1352 SSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRL 1411
             S   + A    ++ C     P   +    +G  +AT  GV +     G +++A  +   
Sbjct: 3954 PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVAT--GVSTQVLPGGQLRIAHAS--- 4008

Query: 1412 QVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAE--PGLDVPEGAALNLSCRLLG 1469
                 P     Y+C A+N  GS     RL V+   V+    P L   EG+   L C+  G
Sbjct: 4009 -----PEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARG 4063

Query: 1470 GPGPVGNSTFAWFWN---------DRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAA 1520
             P P  N T    W+         + +   +P   L   ++    AG Y C AE   G A
Sbjct: 4064 SPEP--NIT----WDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRA 4117

Query: 1521 ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQG 1580
                V L +L  P   T+        G R  L C     P   +   +  R V       
Sbjct: 4118 RRR-VHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG---- 4172

Query: 1581 APAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
                    V        +   A+   D G Y+C A N +G     ++  V+
Sbjct: 4173 --------VSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 4215



 Score =  202 bits (513), Expect = 3e-51
 Identities = 373/1573 (23%), Positives = 580/1573 (36%), Gaps = 263/1573 (16%)

Query: 194  TGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNIL 253
            + VG L  L  A   Q+      C   V N  +  ++ L+V   P+       P+  +++
Sbjct: 2214 SAVGRLLYLGQAQLAQEGTYTCECSNVVGN--SSQDLQLEVHVPPQIAGPREPPTQVSVV 2271

Query: 254  PGELVTLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTC 305
               + TL C      P   ++ W +DG        ++LQ +   LH+ +A  +  G Y+C
Sbjct: 2272 QDGVATLECNATGKPPP--TVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 2329

Query: 306  QAENGVGSLVSPPISLHIFMAEVQVSPAGPILE-----NQTVTLVCNTPNEAPSDLRYSW 360
             AEN  G        L + +    +    P+       +  +TL+C      P  +R  W
Sbjct: 2330 VAENLAGR-AERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIR--W 2386

Query: 361  YKNHVLL---EDAH----SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413
            ++    +   ED +       L++      D+G Y C   N  G  R    SV V  PP 
Sbjct: 2387 FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRN-FSVEVLVPPS 2445

Query: 414  --TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGP 471
                 L   ++   G    L C+V   P   L     G  LA   GD+ H         P
Sbjct: 2446 IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR--GDAHHI-------SP 2496

Query: 472  NSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAE-------VVEG 524
            + + L++     + +G Y C A N++G  T         A  ++  A +       V   
Sbjct: 2497 DGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVN 2556

Query: 525  QAVTLSCRSGLSPTPDARFSWYLNGALLHEG------PGS-SLLLPAASSTDAGSYHCRA 577
              ++L C +   P+P+   +W  +GA           PG+  L +  A   DAG Y C  
Sbjct: 2557 NPISLICEALAFPSPN--ITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVV 2614

Query: 578  RDGHSASGPSSPAVLTVLYPPR--QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635
             +    +  +    + VL PP   +      + +            L C   + PP  ++
Sbjct: 2615 TNELGEAVKNYH--VEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIR 2672

Query: 636  LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695
              +KD    T              S R++V     LL+++     + + G YLC A+N  
Sbjct: 2673 W-YKDGQPVTP-------------SSRLQVLGEGRLLQIQPTQ--VSDSGRYLCVATNVA 2716

Query: 696  GNASTS--------------ATFNGQATVLA--------IAPSHTLQEGTEANLTCNVSR 733
            G                     F+    +L+        +     + E   A L C+ + 
Sbjct: 2717 GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTN- 2775

Query: 734  EAAGSPANFSWFRNGVLWAQGPLETVTL------LPVARTD-AALYACRILTEAGAQLST 786
              A  P + +W+R     + G   +V        +P+ R + A  Y+C+   E G     
Sbjct: 2776 --AIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 2833

Query: 787  PVLLSVLYPP----DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGP 842
              LL VL PP    D  +L   + +         C     P+  ++        + S   
Sbjct: 2834 YELL-VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRL 2892

Query: 843  QVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSP 902
            QV   G+           L+V    + D+ SY C A N  GS+     F +R   VQV P
Sbjct: 2893 QVLEDGQV----------LQVSTAEVADAASYMCVAENQAGSAEK--LFTLR---VQVPP 2937

Query: 903  ---SPELQEGQAVV-----LSCQVHTGV-PEGTSYRWYRDGQPLQESTSA-------TLR 946
                 +L++  A++     L C VH    PE T   WY+D Q L             TL+
Sbjct: 2938 RIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT---WYKDSQALSLGEEVFLLPGTHTLQ 2994

Query: 947  FAAITLTQAGAYHCQA-QAPG--SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLL 1003
                 L+ +G Y C+A  A G       L+  +      APR      L+  G     +L
Sbjct: 2995 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDK--AVL 3052

Query: 1004 LCRVDSDP-PAQLRLLHGDRLV-ASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061
             C  D+ P P       G  LV A   Q + G +               RLEI  A + D
Sbjct: 3053 SCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ---------------RLEIQEAQVSD 3097

Query: 1062 EGVYICEASNTLGQASASADFDAQAVNVQVWPGA-TVRE--GQLVNLTCLVWTTHPAQLT 1118
            +G+Y C+ SN  G+A  +     Q       P   TV +  G  + LTC V +  PA  T
Sbjct: 3098 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAP-T 3155

Query: 1119 YTWYQDGQQRLDAHSIPLPNVTVR------------DATSYRCGVGPPGRAPRLSRPITL 1166
             TW +D   R+   S  +  V  R             A +Y C         R  +   +
Sbjct: 3156 VTWLKD---RMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR--KDFVV 3210

Query: 1167 DVLYAPRNLRLTYLLESH---GGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT 1223
             VL APR +R + +   H    GQ   + C  D +PP  +A    G  L       +   
Sbjct: 3211 AVLVAPR-IRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY 3269

Query: 1224 L---RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP---EAAVPEGAPI 1277
            L    L L+G +  D G Y+C A +P G+     + RL  V V++ P   + A   G  +
Sbjct: 3270 LDGGSLVLKGLRASDAGAYTCVAHNPAGE-----DARLHTVNVLVPPTIKQGADGSGTLV 3324

Query: 1278 T-----VTCADPAAHAPTLY-TWYHNG-------RWLQEGPAASLSFLVATRAHAGAYSC 1324
            +     VT   P   +P ++ +W  +G       R L  G   +L       A AG ++C
Sbjct: 3325 SRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC 3384

Query: 1325 QAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRA--RSMAVIQCTVDSEPPAELALSHD 1382
             A    G  + R   LQV   P    +    D      S+  + C     P   ++   D
Sbjct: 3385 VAASPAGV-ADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD 3443

Query: 1383 GKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQ 1441
            G+ L +     SL  G            LQ++ V AGD  TY C A +  G      +L 
Sbjct: 3444 GEPLLS----QSLEQGPS----------LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 3489

Query: 1442 VEGARVVAEPG----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLA 1497
            V     + + G    L +  GA + L C   G P P       W  + + L      + A
Sbjct: 3490 VMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQP----NITWHKDGQALTRLENNSRA 3545

Query: 1498 FTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYP-----PKTPTMMVFVEPEGGLRGIL 1552
               +    AG+Y CLAE P GA   +   +RV  P     P+ P  +V + P G L  +L
Sbjct: 3546 TRVLRVRDAGLYTCLAESPAGAIEKS-FRVRVQAPPNIVGPRGPRFVVGLAP-GQL--VL 3601

Query: 1553 DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612
            +C V++EP   +T H            G   +   H         + ++AL  +D G+Y 
Sbjct: 3602 ECSVEAEPAPKITWH----------RDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYS 3651

Query: 1613 CSASNVLGSASTS 1625
            C+A N  GS S +
Sbjct: 3652 CTARNAAGSTSVA 3664



 Score =  201 bits (510), Expect = 7e-51
 Identities = 379/1557 (24%), Positives = 563/1557 (36%), Gaps = 298/1557 (19%)

Query: 258  VTLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTCQAEN 309
            V+L C V++ +P    + W KD         V L   T  L L +A  SD+G+YTC+A N
Sbjct: 2955 VSLPCDVHA-HPN-PEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALN 3012

Query: 310  GVG---SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVL 366
              G    LV   + +     +    P   +L       V +   +A  +   +WYK+   
Sbjct: 3013 AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQP 3072

Query: 367  LEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPP-LTPVLT 418
            L  A           L +  A  +D G Y C+V NV G E     ++ V  PP      T
Sbjct: 3073 LVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKT 3131

Query: 419  AFLETQAGLVGILHCSVVSEPLATL--------VLSHGGHILASTSGDSDHSPRFSGTSG 470
              +   AG   +L C V   P  T+        V S   H + S  G             
Sbjct: 3132 ETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGG------------- 3178

Query: 471  PNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN---AARLLISPAAE---VVEG 524
                RL++  L+   +G Y C A N+   A    DF      A R+  S  A    V+EG
Sbjct: 3179 ----RLQLSRLQPAQAGTYTCVAENTQAEARK--DFVVAVLVAPRIRSSGVAREHHVLEG 3232

Query: 525  QAVTLSCRSGLSPTPDARFSWYLNGALLHE--GP-------GSSLLLPAASSTDAGSYHC 575
            Q V L C +   P PD   +W  +G+ L +  GP       G SL+L    ++DAG+Y C
Sbjct: 3233 QEVRLDCEADGQPPPDV--AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 3290

Query: 576  RARDGHSASGPSSPA-VLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLL---CRVDSDPP 631
             A   H+ +G  +    + VL PP     T +   D +G    R G L+   C V   PP
Sbjct: 3291 VA---HNPAGEDARLHTVNVLVPP-----TIKQGADGSGTLVSRPGELVTMVCPVRGSPP 3342

Query: 632  ARLQLL------------------HKDRVVATSLPSGGGCSTCGGCSPR--------MKV 665
              +  L                  H  R+    L +  G  TC   SP         ++V
Sbjct: 3343 IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQL-ADAGIFTCVAASPAGVADRNFTLQV 3401

Query: 666  TKAPNLLRVEIHNPLLEEEGLYL---CEASN----------------------------- 693
               P L  VE  N ++   G  +   CEA                               
Sbjct: 3402 QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLE 3461

Query: 694  ALGNASTSATFN-------GQAT----VLAIAPSHTLQEG--TEANLTCNVSRE----AA 736
            A+G A  S T++       G+A     +  + P H    G  TE +LT     E    A 
Sbjct: 3462 AVG-AGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 3520

Query: 737  GSPA-NFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP 795
            G+P  N +W ++G    +    +     +   DA LY C   + AGA +     + V  P
Sbjct: 3521 GTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGA-IEKSFRVRVQAP 3579

Query: 796  PD-----RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRF 850
            P+      P+    L  GQ    +  C+V++ P   +       +L      Q P  GRF
Sbjct: 3580 PNIVGPRGPRFVVGLAPGQ---LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF 3636

Query: 851  QAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV----SPSPEL 906
                      L+++ L   DSG Y C A N  GS  TS+ F+V    V       P+  +
Sbjct: 3637 ----------LQLQALSTADSGDYSCTARNAAGS--TSVAFRVEIHTVPTIRSGPPAVNV 3684

Query: 907  QEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST-------SATLRFAAITLTQAGAYH 959
               Q  +L CQ   GVP      W +D  PL   +         +LR   +    AG Y 
Sbjct: 3685 SVNQTALLPCQAD-GVP-APLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL 3742

Query: 960  CQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDP-PAQLRL 1017
            C A  + GS        +    + AP    LT    T      LL C     P P  +  
Sbjct: 3743 CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTP----ALLPCEASGSPKPLVVWW 3798

Query: 1018 LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQAS 1077
              G +L     QG      S+  L  A  P            +D   + C  SN +G+A 
Sbjct: 3799 KDGQKLDFRLQQGAYRLLPSNALLLTAPGP------------QDSAQFECVVSNEVGEAH 3846

Query: 1078 ASADFDAQAVNVQVWPGATVREGQ----LVNLTCLVWTTHPAQL---TYTWYQDGQQRLD 1130
                     V V V P  T+ + Q    +  +  +V T H   +   T +W + G Q L 
Sbjct: 3847 R-----LYQVTVHVPP--TIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ-LG 3898

Query: 1131 AHSIPLPNVTVRDATSYRCGVGPPGRAPRLS-----------RPITLDVLYAPRNLRLTY 1179
            A         V  + +   G   P  A R +           + + L V  +P    L  
Sbjct: 3899 ARG---SGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPS 3955

Query: 1180 LLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFY 1239
            ++ +   +  L+ C     P   +     G  +A+  +  V    +L +    P D G Y
Sbjct: 3956 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNY 4015

Query: 1240 SCSARSPLGQA--NTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN 1297
             C A++  G A   T L +++  V     P+ +  EG+   + C    +  P + TW  +
Sbjct: 4016 LCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNI-TWDKD 4074

Query: 1298 GRWLQ--EG-----PAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAV 1350
            G+ +   EG     P+  L         AG Y+C A++A G R+ R   L +L  P    
Sbjct: 4075 GQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG-RARRRVHLTILVLPVFTT 4133

Query: 1351 LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR 1410
            L   R  R      ++C     P   +  + + + +          S      V+R    
Sbjct: 4134 LPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSRE--- 4190

Query: 1411 LQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV---AEPGLDVPEGAALNLSCRL 1467
                       TYVC A+N +G    +  + V+ A V+   A   L  P G ++ L C +
Sbjct: 4191 --------DSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV 4242

Query: 1468 LGGPGPVGNSTFAWFWNDRRL------HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAA 1521
             G P P       W  +   L      H     +L      R  AG Y CLAE   G A 
Sbjct: 4243 RGDPVP----DIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAK 4298

Query: 1522 SAPVMLRVLYPPKTPTMMVF-VEPE-----GGLRGILDCRVDSEPLASLT-LHLGSRLVA 1574
               +++    P       VF VEP+      G    L C+   EP  ++  L  G  L A
Sbjct: 4299 KVVILVLQSAP-------VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRA 4351

Query: 1575 SSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
            S + +  P               + +E +   D G Y C A N+LGSA+   +  VR
Sbjct: 4352 SRRLRTLPDGS------------LWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 4396



 Score =  199 bits (507), Expect = 1e-50
 Identities = 379/1600 (23%), Positives = 553/1600 (34%), Gaps = 312/1600 (19%)

Query: 210  DHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYP 269
            D GR  +C  S AN   ++ + L V+ AP+   + +  S ++   G  V ++C   S YP
Sbjct: 581  DGGRY-QCVASNANGVTRASVWLLVREAPQ---VSIHTSSQHFSQGVEVKVSCSA-SGYP 635

Query: 270  AVSSIKWLKDGVRLQTKT-------GVLHLPQAAWSDAGVYTCQAENGVGS-------LV 315
                I W ++   LQ  +       G L +   A  DAG Y+CQA N VG+         
Sbjct: 636  T-PHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY 694

Query: 316  SPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLL----EDAH 371
            + P S+    A V V+        +   LVC      P   R  WY+  + +    E + 
Sbjct: 695  TDPPSVSAVNAVVLVAVG------EEAVLVCEASGVPPP--RVIWYRGGLEMILAPEGSS 746

Query: 372  SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGIL 431
            S  LR+  A   D G Y C   N  G + S  + + V H P    L   +  + G   +L
Sbjct: 747  SGKLRIPAAQERDAGTYTCRAVNELG-DASAEIQLAVGHAPQLTELPRDVTVELGRSALL 805

Query: 432  HCSVVSEPLATLVLSHG-GHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYK 490
             C     P  T+    G G  L    G    + R S +  P+S  L    +   D   Y 
Sbjct: 806  ACRATGRPPPTVTWRRGDGQPLGLRLG----AGRGSRSRQPDSGVLFFESVAPEDQAPYV 861

Query: 491  CSATNSLGN----ATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWY 546
            C A N  G     A   +  HA       +P   V+EGQ V+L C   L+  P     W 
Sbjct: 862  CEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIV-LAGRPLPERHWL 920

Query: 547  LNGALLHEGP------GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPR- 599
             +G  L  G         SL L  A    AG Y C A +  +A        L V  PPR 
Sbjct: 921  KDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATN--TAGSQHRDVELVVQVPPRI 978

Query: 600  QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGC 659
             PT T  +  +   A       L C V S  PA      K+    TS             
Sbjct: 979  HPTATHHITNEGVPAS------LPC-VASGVPAPTITWTKETNALTSR------------ 1019

Query: 660  SPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLA------- 712
             P   V+K   LL   I  P  ++ G Y+C A+N +G +S     +     L+       
Sbjct: 1020 GPHYNVSKEGTLL---IAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEY 1076

Query: 713  -IAPSHTL-----QEGTEANLTCNVSREAA------------------------------ 736
             + PS +L     Q G   +  C  S  A                               
Sbjct: 1077 GLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEA 1136

Query: 737  --------GSP-ANFSWFRNG-VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLST 786
                    G+P    SW ++G VL  +GP  +V    +  +DA  Y C     AG   + 
Sbjct: 1137 LDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVD-AW 1195

Query: 787  PVLLSVLYPP--DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQV 844
             V L VL PP     + S LL+   G  A   C     P   +    G            
Sbjct: 1196 EVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGP--------SSE 1247

Query: 845  PSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSP 904
            P HG+    A      L +  +   DSG Y C+ATN +GS++       R A + V   P
Sbjct: 1248 PLHGQ-PGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTS-------RRAKLVVYVPP 1299

Query: 905  ELQE-----------GQAVVLSCQVH---------------TGVP-----EGTSYRWYRD 933
             ++E           GQ++ L C  +                GVP      G    W + 
Sbjct: 1300 SIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQV 1359

Query: 934  GQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLM 993
            G         +L F  I    +G Y C+A+          A    H+      +T  +++
Sbjct: 1360 GGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG-----TAQRDFHLLV----LTPPSVL 1410

Query: 994  DTGPGR--LGL------LLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAV 1045
              G  +  LGL      L C     P  Q+      + V       GGP       H+ V
Sbjct: 1411 GAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLP-----GGP-------HLQV 1458

Query: 1046 APNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG-----ATVREG 1100
              +   L I G+ + DEG Y C A +  GQ +        A    +W         V E 
Sbjct: 1459 QEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT-IWGSNETGEVAVMED 1517

Query: 1101 QLVNLTCLVWTTHPAQLTYTWYQDGQ---------QRLDAHSIPLPNVTVRDATSYRC-- 1149
             LV L C         +  TW++DG                 + L      DA  Y C  
Sbjct: 1518 HLVQLLCEARGVPTPNI--TWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKA 1575

Query: 1150 --GVGPPGRAPRLSRPITLDVLYAPRNLR----LTYLLESHGGQLALVLCTVDSRPPAQL 1203
               VG   +A RL        +Y P  +       Y++++  G+   + C     P   L
Sbjct: 1576 SNAVGAAEKATRLD-------VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL 1628

Query: 1204 ALSHAGRLLASSTAASVP---NTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG 1260
            +  H G  +A S  + +    + LRLE   P     G YSC A SP G+A     + ++ 
Sbjct: 1629 SWHHEGLPVAESNESRLETDGSVLRLE--SPGEASSGLYSCVASSPAGEAVLQYSVEVQV 1686

Query: 1261 VRVILAPE----AAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQE-------GPAASL 1309
               +L  E         G P+ + C    +  PT+  W  NGR  +E           +L
Sbjct: 1687 PPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTI-QWLQNGRPAEELAGVQVASQGTTL 1745

Query: 1310 SFLVATRAHAGAYSCQAQDAQGTRSSR----------PAALQVLYAPQDAVLSSFRDSRA 1359
                    H+G ++CQA +  GT  +           P  L+V                A
Sbjct: 1746 HIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPA 1805

Query: 1360 RSMAVIQ--CTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVP 1417
                 +        +PP        G +    +G+    S    +Q+ +  LR       
Sbjct: 1806 ACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLR------- 1858

Query: 1418 AGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPG---LDVPEGAALNLSCRLLGGPGPV 1474
              +  Y C A NL G       L+V     + EPG     V E A++ L C   G P P 
Sbjct: 1859 -DEGIYTCAATNLAGESKREVALKVLVPPNI-EPGPVNKAVLENASVTLECLASGVPPP- 1915

Query: 1475 GNSTFAWFWNDRRLHAEPVPTLA----FTHVARAQ---AGMYHCLA-------ELPTGAA 1520
                 +WF   + + +    T++       + +AQ   AG Y C+A       EL  G  
Sbjct: 1916 ---DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLR 1972

Query: 1521 ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQG 1580
             + P   R+  PP  P  ++   P       L C     P  +L        +    P  
Sbjct: 1973 VNVPP--RITLPPSLPGPVLVNTPVR-----LTCNATGAPSPTL------MWLKDGNPVS 2019

Query: 1581 APAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620
                P + V   P    + + + R SD G Y C A + +G
Sbjct: 2020 PAGTPGLQVF--PGGRVLTLASARASDSGRYSCVAVSAVG 2057



 Score =  191 bits (485), Expect = 5e-48
 Identities = 366/1491 (24%), Positives = 540/1491 (36%), Gaps = 263/1491 (17%)

Query: 270  AVSSIKWLKDGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQ 329
            A+S   W + G+     +G L L Q    D+G Y C A N  GS      + H ++  VQ
Sbjct: 1067 ALSKYVWEEYGL---LPSGSLRLAQVQVGDSGHYECTASNPAGS------ASHRYVLGVQ 1117

Query: 330  VSPA---GP----ILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATR 382
            V P    GP    +L  + + L C    E   + + SW K+ V+L+           A R
Sbjct: 1118 VPPQVQPGPRVLKVLVGEALDLNCVA--EGNPEPQLSWSKDGVVLQGRGPQGSVHFAAIR 1175

Query: 383  -ADTGFYFCEVQNVHGSERSGPVSVVVNHPPL--TPVLTAFLETQAGLVGILHCSVVSEP 439
             +D G Y CE  N  G + +  V + V  PP       +  LE  AG    L C     P
Sbjct: 1176 TSDAGRYRCEASNSAGVD-AWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTP 1234

Query: 440  LATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGN 499
               +    G       S +  H     G +      L +  +   DSG+Y+C ATN +G+
Sbjct: 1235 KPQVTWRKG------PSSEPLHGQ--PGVAVLEEGSLFLASVSPADSGDYECQATNEVGS 1286

Query: 500  ATSTLDFHANAARLLISPAAEVVE-----------GQAVTLSCRSGLSPTPD-------- 540
                    +  A+L++     + E           GQ++TL C +   P P+        
Sbjct: 1287 T-------SRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQ 1339

Query: 541  --------ARFSWYLNGA------LLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGP 586
                    A + W L         LL E  G SL  P     D+G Y CRA   + A   
Sbjct: 1340 LVGVPLGWAGYGWDLGWGQVGGHRLLDE--GQSLHFPRIQEGDSGLYSCRAE--NQAGTA 1395

Query: 587  SSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVD-------SDPPARLQLLHK 639
                 L VL PP              GAGA +  L L   D       S  P       K
Sbjct: 1396 QRDFHLLVLTPP-----------SVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTK 1444

Query: 640  DRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNAS 699
            DR     LP G          P ++V +   +LR  I    + +EG Y C A +  G  +
Sbjct: 1445 DR--QPVLPGG----------PHLQVQEDGQVLR--ITGSHVGDEGRYQCVAFSPAGQQA 1490

Query: 700  TSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNG--------VL 750
                    A       + T +     +    +  EA G P  N +WF++G        V+
Sbjct: 1491 RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVV 1550

Query: 751  WAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQG 810
            + +G  + + L     +DA +Y C+     GA       L V  PP           G G
Sbjct: 1551 YTRGGRQ-LQLGRAQSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIE--------GAG 1600

Query: 811  HMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLE-------V 863
                 +  V  RP+AL  +  G         P +  H      AE+N  +LE       +
Sbjct: 1601 GRPYVVKAVAGRPVALECVARGHP------SPTLSWHHEGLPVAESNESRLETDGSVLRL 1654

Query: 864  RELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE---------GQAVVL 914
               G   SG Y C A++  G +   L + V    VQV P   + E         GQ + L
Sbjct: 1655 ESPGEASSGLYSCVASSPAGEA--VLQYSVE---VQVPPQLLVAEGLGQVTTIVGQPLEL 1709

Query: 915  SCQVHTGVPEGTSYRWYRDGQPLQE-------STSATLRFAAITLTQAGAYHCQAQAPGS 967
             CQ  +G P  T  +W ++G+P +E       S   TL    + L  +G + CQA    +
Sbjct: 1710 PCQA-SGSPVPT-IQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA-TNEA 1766

Query: 968  ATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRL-LHGDRLVAS 1026
             T      +S+H  +AP  V    +     G           DPP       H    +  
Sbjct: 1767 GTAGAEVEVSVHGEWAP-GVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVE 1825

Query: 1027 TLQGVGGPEGSSPRLHVAVA-PNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQ 1085
                 G   G    + VA + P  L++E     L DEG+Y C A+N  G++         
Sbjct: 1826 GWCSPGSLWGEPTGIPVAYSLPPPLQIE--KVDLRDEGIYTCAATNLAGESKREVALKVL 1883

Query: 1086 A-VNVQVWP-GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ---------RLDAHSI 1134
               N++  P    V E   V L CL     P  +  +W++  Q           +D   +
Sbjct: 1884 VPPNIEPGPVNKAVLENASVTLECLASGVPPPDV--SWFKGHQPVSSWMGVTVSVDGRVL 1941

Query: 1135 PLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV---LYAPRNLRLTYLLESHGGQLALV 1191
             +    + DA SYRC       +  L   + ++V   +  P +L    L+ +       +
Sbjct: 1942 RIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP----VRL 1997

Query: 1192 LCTVDSRPPAQLALSHAGRLLASSTAASV---PNTLRLELRGPQPRDEGFYSCSARSPLG 1248
             C     P   L     G  ++ +    +   P    L L   +  D G YSC A S +G
Sbjct: 1998 TCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG 2057

Query: 1249 QANTSLELRLEGVRVILAPE--AAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPA 1306
            +    + L++     IL  E   +V     + + C   A   P L +W+ +GR L+  P 
Sbjct: 2058 EDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVL-SWWKDGRPLEPRPG 2116

Query: 1307 ASLS----FLVATRA---HAGAYSCQAQDAQGTRSSRPAALQVLYAP----QDAVLSSFR 1355
              LS     L   RA    AG Y+C+A +  G  S +   L V  AP    +++   + R
Sbjct: 2117 VHLSADKALLQVDRADVWDAGHYTCEALNQAG-HSEKHYNLNVWVAPVFPLRESHTLTVR 2175

Query: 1356 DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQD 1415
            +    S++   C     P  +++   DG+ L          +G  HV      L L  Q 
Sbjct: 2176 EGHPTSLS---CECRGVPFPKISWRKDGQPLPGE------GAGLQHVSAVGRLLYLG-QA 2225

Query: 1416 VPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEP-----GLDVPEGAALNLSCRLLGG 1470
              A + TY C   N++G+ S   +L+V     +A P      + V +     L C   G 
Sbjct: 2226 QLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGK 2285

Query: 1471 PGPVGNSTFAWFWNDRRLHAEPVPTL----AFTHVARAQA---GMYHCLAELPTGAAASA 1523
            P P    T  W  + + + AE    L       HV RAQA   G Y C+AE   G  A  
Sbjct: 2286 PPP----TVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG-RAER 2340

Query: 1524 PVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQG--- 1580
               L VL PP+             L G LD      PL ++T  L S L    +  G   
Sbjct: 2341 KFELSVLVPPE-------------LIGDLD------PLTNITAALHSPLTLLCEAMGIPP 2381

Query: 1581 ---------APAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
                      P  P            + +   +  D G Y C ASN  G A
Sbjct: 2382 PAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEA 2432



 Score =  179 bits (454), Expect = 2e-44
 Identities = 398/1681 (23%), Positives = 604/1681 (35%), Gaps = 297/1681 (17%)

Query: 100  LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRV---PTIASPVELLEGTEV 156
            L ++  Q  D+GSY  R   S V   ++++  L  V   PR+   P++  PV  L  T V
Sbjct: 1941 LRIEQAQLSDAGSY--RCVASNVAGSTELRYGL-RVNVPPRITLPPSLPGPV--LVNTPV 1995

Query: 157  DFNCSTPYVCLQEQVRLQW--QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRI 214
               C+           L W   G   + + T   Q F     G + TL  A +  D GR 
Sbjct: 1996 RLTCNATGA---PSPTLMWLKDGNPVSPAGTPGLQVFPG---GRVLTLASARA-SDSGRY 2048

Query: 215  LRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSI 274
                +S      Q ++ LQV   P    IL      +++  E V L CQ ++  P V S 
Sbjct: 2049 SCVAVSAVGEDRQ-DVVLQVHMPPS---ILGEELNVSVVANESVALECQSHAMPPPVLS- 2103

Query: 275  KWLKDGVRLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA 326
             W KDG  L+ + GV        L + +A   DAG YTC+A N  G       S   +  
Sbjct: 2104 -WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGH------SEKHYNL 2156

Query: 327  EVQVSPAGPILENQTVTLVCNTPNEAPSDLR------YSWYKNHVLLE---------DAH 371
             V V+P  P+ E+ T+T+    P     + R       SW K+   L           A 
Sbjct: 2157 NVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAV 2216

Query: 372  SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTP----VLTAFLETQAGL 427
               L L  A  A  G Y CE  NV G+  S  + + V+ PP         T     Q G 
Sbjct: 2217 GRLLYLGQAQLAQEGTYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDG- 2274

Query: 428  VGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
            V  L C+   +P  T+     G  + +  G    +   S         L +   +   +G
Sbjct: 2275 VATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQS---------LHVERAQAAHTG 2325

Query: 488  EYKCSATNSLGNATSTLDFHANAARLLIS---PAAEVVEG--QAVTLSCRSGLSPTPDAR 542
             Y C A N  G A    +        LI    P   +       +TL C +   P P  R
Sbjct: 2326 RYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIR 2385

Query: 543  FSWYLNGALLHEGPGSSLL-------LPAASSTDAGSYHCRARDGHSASGPSSPAVLTVL 595
              W+     +  G  + LL       +      D+G Y C A   + A        + VL
Sbjct: 2386 --WFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA--SNEAGEARRNFSVEVL 2441

Query: 596  YPPRQPTFTTRLDLDAA-GAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCS 654
             PP         DL+       G+   L+C V   P  +L      R +A          
Sbjct: 2442 VPPS----IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR--------- 2488

Query: 655  TCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIA 714
               G +  +    +P+ + +++    L   G Y C A+NA+G      T + Q +VL +A
Sbjct: 2489 ---GDAHHI----SPDGVLLQVLQANLSSAGHYSCIAANAVG----EKTKHFQLSVL-LA 2536

Query: 715  PS--HTLQEGTEANLTCNVSR------EAAGSPA-NFSWFRNGVLWAQGPLETVTLLP-- 763
            P+     ++  +  +T  V+       EA   P+ N +W ++G  +       + LLP  
Sbjct: 2537 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEAS--RNIQLLPGT 2594

Query: 764  -------VARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFI 816
                     + DA  Y C +  E G  +     + VL PP   K   L ++G   +   +
Sbjct: 2595 HGLQILNAQKEDAGQYTCVVTNELGEAVKN-YHVEVLIPPSISKDDPLGEVGVKEVKTKV 2653

Query: 817  -------CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869
                   C   + P   +  +     +  S   QV   GR           L+++   + 
Sbjct: 2654 NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL----------LQIQPTQVS 2703

Query: 870  DSGSYRCEATNVLGSSNTSL--------FFQVRG--------------AWVQVSPSPELQ 907
            DSG Y C ATNV G  +            FQ  G              A   V+   E+ 
Sbjct: 2704 DSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIV 2763

Query: 908  EGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT-------LRFAAITLTQAGAYHC 960
            E     L C  +   P   +  WYR+ QPL      +       L+   +    AG Y C
Sbjct: 2764 ENNPAYLYCDTNAIPPPDLT--WYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSC 2821

Query: 961  QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020
            +A       ++      LH  Y    +T   ++      +  +     S    Q   L  
Sbjct: 2822 KA-------SNEVGEDWLH--YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN 2872

Query: 1021 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080
                 S LQ  G P   SPRL V        L++  A + D   Y+C A N  G A    
Sbjct: 2873 PVPTISWLQN-GLPFSPSPRLQVLEDGQV--LQVSTAEVADAASYMCVAENQAGSAE--- 2926

Query: 1081 DFDAQAVNVQVWP--------GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL--- 1129
                  + VQV P          T      V+L C V   HP     TWY+D Q      
Sbjct: 2927 --KLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDV-HAHP-NPEVTWYKDSQALSLGE 2982

Query: 1130 ------DAHSIPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVL------YAPRNLR 1176
                    H++ L    + D+  Y C  +   GR  +L   + L VL       APR  +
Sbjct: 2983 EVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL---VQLSVLVPPAFRQAPRGPQ 3039

Query: 1177 LTYLLESHGGQLALVLCTVDSRPPAQLALSHAGR-LLASSTAASVPNTLRLELRGPQPRD 1235
               L+    G  A++ C  D+ P   +     G+ L+ +    ++    RLE++  Q  D
Sbjct: 3040 DAVLVRV--GDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSD 3097

Query: 1236 EGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE---GAPITVTCADPAAHAPTLY 1292
            +G YSC   +  G+A  +  L ++       P+        G+P+ +TC      APT+ 
Sbjct: 3098 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV- 3156

Query: 1293 TWYHNGRWLQEGP-------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYA 1345
            TW  +   ++             L       A AG Y+C A++ Q   + +   + VL A
Sbjct: 3157 TWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQ-AEARKDFVVAVLVA 3215

Query: 1346 PQDAVLSSFRDSRARSMAVIQ--CTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403
            P+       R+        ++  C  D +PP ++A   DG  L    G H      G   
Sbjct: 3216 PRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSL 3275

Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV-------EGA----RVVAEPG 1452
            V +    L+  D  A    Y C A N  G  + +  + V       +GA     +V+ P 
Sbjct: 3276 VLKG---LRASDAGA----YTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRP- 3327

Query: 1453 LDVPEGAALNLSCRLLGGPGPVGNSTFAWF-------WNDRRLHAEPVPTLAFTHVARAQ 1505
                 G  + + C + G P P+  S   W         + R L      TL  + V  A 
Sbjct: 3328 -----GELVTMVCPVRGSP-PIHVS---WLKDGLPLPLSQRTLLHGSGHTLRISKVQLAD 3378

Query: 1506 AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI---LDCRVDSEPLA 1562
            AG++ C+A  P G  A     L+V  PP     + F      +RG    L C     PL 
Sbjct: 3379 AGIFTCVAASPAG-VADRNFTLQVQVPPVLEP-VEFQNDVVVVRGSLVELPCEARGVPLP 3436

Query: 1563 SLT-LHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621
             ++ +  G  L++ S  QG                 + +EA+   D G Y C A +  G 
Sbjct: 3437 LVSWMKDGEPLLSQSLEQGP---------------SLQLEAVGAGDSGTYSCVAVSEAGE 3481

Query: 1622 A 1622
            A
Sbjct: 3482 A 3482



 Score =  176 bits (445), Expect = 2e-43
 Identities = 378/1579 (23%), Positives = 578/1579 (36%), Gaps = 296/1579 (18%)

Query: 200  ETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVT 259
            ++LH+  +   H     C       RA+ +  L V   P+ +  L   +         +T
Sbjct: 2312 QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLT 2371

Query: 260  LTCQVNSSYPAVSSIKWLK--------DGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGV 311
            L C+     P   +I+W +        +   L     +L + Q    D+G+Y+C A N  
Sbjct: 2372 LLCEAMGIPPP--AIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEA 2429

Query: 312  GSLVSPPISLHIFMAEVQVSPAGP---------ILENQTVTLVCNTPNEAPSDLRYSWYK 362
            G       +   F  EV V P+           +L+ QT  L+CN        L  +W+K
Sbjct: 2430 GE------ARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFK 2481

Query: 363  NHVLLEDAHSH-------TLRLHLATRADTGFYFCEVQNVHGSE-RSGPVSVVVNHPPLT 414
            +   L    +H        L++  A  +  G Y C   N  G + +   +SV+     L 
Sbjct: 2482 DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL-----LA 2536

Query: 415  PVLTAFLETQAG---LVGI-----LHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466
            P +    E  A     V +     L C  ++ P   +     G    +    S +     
Sbjct: 2537 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEA----SRNIQLLP 2592

Query: 467  GTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA-------- 518
            GT G     L+I + ++ D+G+Y C  TN LG A    ++H     +LI P+        
Sbjct: 2593 GTHG-----LQILNAQKEDAGQYTCVVTNELGEAVK--NYH---VEVLIPPSISKDDPLG 2642

Query: 519  ------AEVVEGQAVTLSCRSGLSPTPDARFSWYLNG-------ALLHEGPGSSLLLPAA 565
                   +      +TL C S   P P  R  WY +G        L   G G  L +   
Sbjct: 2643 EVGVKEVKTKVNSTLTLECESWAVPPPTIR--WYKDGQPVTPSSRLQVLGEGRLLQIQPT 2700

Query: 566  SSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP---RQPTFTTRLDL-----DAAGAGAG 617
              +D+G Y C A +           ++ V  PP   +   F+   ++     +A G    
Sbjct: 2701 QVSDSGRYLCVATNVAGEDDQDFNVLIQV--PPMFQKVGDFSAAFEILSREEEARGGVTE 2758

Query: 618  RRGL-------LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPN 670
             R +       L C  ++ PP  L    +D+     L +G   S   G     +V + P 
Sbjct: 2759 YREIVENNPAYLYCDTNAIPPPDLTWYREDQ----PLSAGDEVSVLQG----GRVLQIP- 2809

Query: 671  LLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCN 730
            L+R        E  G Y C+ASN +G              + +  +  L E    N +  
Sbjct: 2810 LVRA-------ENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASST 2862

Query: 731  VSRE--AAGSPA-NFSWFRNGVLWAQGP----LETVTLLPVAR---TDAALYACRILTEA 780
            VS +  A G+P    SW +NG+ ++  P    LE   +L V+     DAA Y C    +A
Sbjct: 2863 VSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQA 2922

Query: 781  GAQLSTPVLLSVLYPP-----DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHL 835
            G+       L V  PP     D  +++A+L+          C V + P   +  +     
Sbjct: 2923 GS-AEKLFTLRVQVPPRIAGLDLEQVTAILNSS----VSLPCDVHAHPNPEVTWYKDSQ- 2976

Query: 836  LATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN--TSLFFQV 893
             A SLG +V             +  L++    L DSG Y CEA N  G       L   V
Sbjct: 2977 -ALSLGEEV--------FLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV 3027

Query: 894  RGAWVQVSPSPE----LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP--LQESTSA---- 943
              A+ Q    P+    ++ G   VLSC+    +PE T   WY+DGQP  L + T A    
Sbjct: 3028 PPAFRQAPRGPQDAVLVRVGDKAVLSCET-DALPEPT-VTWYKDGQPLVLAQRTQALRGG 3085

Query: 944  -TLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYA-PRHVTLTTLMDTGPGRL 1000
              L      ++  G Y C+ +   G A  +    + +  ++  P+  T++ +     G  
Sbjct: 3086 QRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQV----AGSP 3141

Query: 1001 GLLLCRVDSDPPAQLRLLHGDRL--VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAM 1058
             +L C V   P   +  L  DR+   +S + GV    G              RL++    
Sbjct: 3142 LVLTCDVSGVPAPTVTWLK-DRMPVESSAVHGVVSRGG--------------RLQLSRLQ 3186

Query: 1059 LEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGAT---------VREGQLVNLTCLV 1109
                G Y C A NT  QA A  DF    V V V P            V EGQ V L C  
Sbjct: 3187 PAQAGTYTCVAENT--QAEARKDF---VVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEA 3241

Query: 1110 WTTHPAQLTYTWYQDGQQ-----------RLDAHSIPLPNVTVRDATSYRC-GVGPPGRA 1157
                P  +   W +DG              LD  S+ L  +   DA +Y C    P G  
Sbjct: 3242 DGQPPPDV--AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 3299

Query: 1158 PRLSRPITLDVLYAP---RNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLAS 1214
             RL    T++VL  P   +    +  L S  G+L  ++C V   PP  ++    G  L  
Sbjct: 3300 ARLH---TVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL 3356

Query: 1215 STAASVPNT-LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP-----E 1268
            S    +  +   L +   Q  D G ++C A SP G A+ +  L+++ V  +L P     +
Sbjct: 3357 SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ-VPPVLEPVEFQND 3415

Query: 1269 AAVPEGAPITVTCADPAAHAPTLYTWYHNG-----RWLQEGPAASLSFLVATRAHAGAYS 1323
              V  G+ + + C       P L +W  +G     + L++GP+  L  + A    +G YS
Sbjct: 3416 VVVVRGSLVELPCEARGVPLP-LVSWMKDGEPLLSQSLEQGPSLQLEAVGA--GDSGTYS 3472

Query: 1324 CQAQDAQGTRSSRPAALQVLYAP--QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSH 1381
            C A    G  + R   L V+  P  +D+   +       +   + C     P   +    
Sbjct: 3473 CVAVSEAG-EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK 3531

Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQ 1441
            DG+ L            T     +R    L+V+D       Y C A++  G+I    R+ 
Sbjct: 3532 DGQAL------------TRLENNSRATRVLRVRDA----GLYTCLAESPAGAIEKSFRV- 3574

Query: 1442 VEGARVVAEPGLDVPEG---------AALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP 1492
                RV A P +  P G           L L C +   P P       W   D  +  E 
Sbjct: 3575 ----RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAP----KITWH-RDGIVLQED 3625

Query: 1493 VPT--------LAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLY--PPKTPTMMVFV 1542
              T        L    ++ A +G Y C A     AA S  V  RV     P   +    V
Sbjct: 3626 AHTQFPERGRFLQLQALSTADSGDYSCTAR---NAAGSTSVAFRVEIHTVPTIRSGPPAV 3682

Query: 1543 EPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEA 1602
                    +L C+ D  P A L      R+         P  P   +L    +LR  I+ 
Sbjct: 3683 NVSVNQTALLPCQADGVP-APLVSWRKDRVPLD------PRSPRFEILPE-GSLR--IQP 3732

Query: 1603 LRPSDQGEYICSASNVLGS 1621
            +   D G Y+C ASN  GS
Sbjct: 3733 VLAQDAGHYLCLASNSAGS 3751



 Score =  162 bits (410), Expect = 3e-39
 Identities = 332/1384 (23%), Positives = 488/1384 (35%), Gaps = 253/1384 (18%)

Query: 252  ILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTG--------VLHLPQAAWSDAGVY 303
            + PGE   L+C+V    P   ++ W++D   L   TG         L +     +D G Y
Sbjct: 528  VSPGETAVLSCRVLGEAPY--NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRY 585

Query: 304  TCQAENGVGSL---------VSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPS 354
             C A N  G            +P +S+H        + +    +   V + C+       
Sbjct: 586  QCVASNANGVTRASVWLLVREAPQVSIH--------TSSQHFSQGVEVKVSCSASGYPTP 637

Query: 355  DLRYSWYKNHVLLEDAHSH-----TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVN 409
             + +S  ++  L ED+  H     TL +      D G Y C+  N  G+++   V++   
Sbjct: 638  HISWS-RESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQE-TVTLYYT 695

Query: 410  HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGG--HILASTSGDSDHSPRFSG 467
             PP    + A +    G   +L C     P   ++   GG   ILA              
Sbjct: 696  DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP------------- 742

Query: 468  TSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFH-ANAARLLISPAAEVVE-GQ 525
              G +S +L I   +E D+G Y C A N LG+A++ +     +A +L   P    VE G+
Sbjct: 743  -EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGR 801

Query: 526  AVTLSCRSGLSPTPDA---RFSWYLNGALLHEGPGSS--------LLLPAASSTDAGSYH 574
            +  L+CR+   P P     R      G  L  G GS         L   + +  D   Y 
Sbjct: 802  SALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYV 861

Query: 575  CRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARL 634
            C AR+        +  ++T   PP+  +              G+   L C V +  P   
Sbjct: 862  CEARNVFGKVQAEARLIVTGHAPPQIAS-----SAPTVRVLEGQPVSLPCIVLAGRPLPE 916

Query: 635  QLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNA 694
            +   KD      LP G   S     S             + +   L E  G Y C A+N 
Sbjct: 917  RHWLKD---GRPLPPGSRHSIRADGS-------------LHLDRALQEHAGRYSCVATNT 960

Query: 695  LGNASTSATFNGQA--TVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFR-NGVL 750
             G+         Q    +   A  H   EG  A+L C     A+G PA   +W +    L
Sbjct: 961  AGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPC----VASGVPAPTITWTKETNAL 1016

Query: 751  WAQGPLETV----TLL---PVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSA 803
             ++GP   V    TLL   P A+ DA  Y C      G   S  + LSV           
Sbjct: 1017 TSRGPHYNVSKEGTLLIAQPSAQ-DAGAYVCTATNTVGFS-SQEMRLSV----------- 1063

Query: 804  LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
                                LAL      E+ L  S                  SL+L  
Sbjct: 1064 ------------------NRLALSKYVWEEYGLLPS-----------------GSLRL-- 1086

Query: 864  RELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE---GQAVVLSCQVHT 920
             ++ +GDSG Y C A+N  GS++      V+    QV P P + +   G+A+ L+C V  
Sbjct: 1087 AQVQVGDSGHYECTASNPAGSASHRYVLGVQ-VPPQVQPGPRVLKVLVGEALDLNC-VAE 1144

Query: 921  GVPEGTSYRWYRDGQPLQ-ESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLH 979
            G PE     W +DG  LQ      ++ FAAI  + AG Y C+A          A  + L 
Sbjct: 1145 GNPE-PQLSWSKDGVVLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVD---AWEVELR 1200

Query: 980  VSYAPRHVTLTT--LMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGS 1037
            V   P      T  L++   G    L C     P  Q+    G    +  L G  G    
Sbjct: 1201 VLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPS--SEPLHGQPG---- 1254

Query: 1038 SPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF----------DAQAV 1087
                 VAV      L +      D G Y C+A+N +G  S  A            D +  
Sbjct: 1255 -----VAVLEEG-SLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKA 1308

Query: 1088 NVQVWPGAT-----------------VREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL- 1129
            NV    G +                 +++ QLV +  L W  +   L   W Q G  RL 
Sbjct: 1309 NVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVP-LGWAGYGWDL--GWGQVGGHRLL 1365

Query: 1130 -DAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHG--G 1186
             +  S+  P +   D+  Y C      +A    R   L VL  P  L      E  G  G
Sbjct: 1366 DEGQSLHFPRIQEGDSGLYSCRA--ENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAG 1423

Query: 1187 QLALVLCTVDSRPPAQLALSHAGR-LLASSTAASVPNTLR-LELRGPQPRDEGFYSCSAR 1244
                + C     P  Q+  +   + +L       V    + L + G    DEG Y C A 
Sbjct: 1424 ADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAF 1483

Query: 1245 SPLGQANTSLELRLEGVRVILAP----EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRW 1300
            SP GQ     +LR+     I       E AV E   + + C       P + TW+ +G  
Sbjct: 1484 SPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNI-TWFKDGAL 1542

Query: 1301 LQEGP-------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSS 1353
            L              L    A  + AG Y+C+A +A G  ++  A    +Y P     + 
Sbjct: 1543 LPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG--AAEKATRLDVYVPPTIEGAG 1600

Query: 1354 FRDSRARSMA----VIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNAL 1409
             R    +++A     ++C     P   L+  H+G  +A S+           ++   + L
Sbjct: 1601 GRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESN--------ESRLETDGSVL 1652

Query: 1410 RLQVQDVPAGDDTYVCTAQNLLGS--ISTIGRLQVEGARVVAEPGLDVPE--GAALNLSC 1465
            RL+     A    Y C A +  G   +     +QV    +VAE    V    G  L L C
Sbjct: 1653 RLE-SPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPC 1711

Query: 1466 RLLGGPGPVGNSTFAWFWNDRRLH-------AEPVPTLAFTHVARAQAGMYHCLAELPTG 1518
            +  G P P    T  W  N R          A    TL   HV    +G++ C A    G
Sbjct: 1712 QASGSPVP----TIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 1767

Query: 1519 AAAS 1522
             A +
Sbjct: 1768 TAGA 1771



 Score =  157 bits (398), Expect = 6e-38
 Identities = 385/1708 (22%), Positives = 608/1708 (35%), Gaps = 308/1708 (18%)

Query: 100  LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159
            L+++ + PED+G+Y+ +   +EV   +D +   +  T+ P V  + + V +  G E    
Sbjct: 662  LIIQGVAPEDAGNYSCQ-ATNEVG--TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 718

Query: 160  CSTPYVCLQEQVRLQWQGQDPARSVTFNS---QKFEPTGVGHLETLHMAMSWQDHGRILR 216
            C                G  P R + +         P G    +    A   +D G    
Sbjct: 719  CEA-------------SGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYT- 764

Query: 217  CQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW 276
            C+       A +EI L V +AP+  ++   P    +  G    L C+     P   ++ W
Sbjct: 765  CRAVNELGDASAEIQLAVGHAPQLTEL---PRDVTVELGRSALLACRATGRPPP--TVTW 819

Query: 277  LKD-----GVRL---------QTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLH 322
             +      G+RL         Q  +GVL     A  D   Y C+A N  G + +    + 
Sbjct: 820  RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 879

Query: 323  IFMAEVQVSPAGP---ILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLR--- 376
               A  Q++ + P   +LE Q V+L C      P   R+ W K+   L     H++R   
Sbjct: 880  TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH-WLKDGRPLPPGSRHSIRADG 938

Query: 377  -LHL--ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHC 433
             LHL  A +   G Y C   N  GS+      VV   P + P  T  + T  G+   L C
Sbjct: 939  SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHI-TNEGVPASLPC 997

Query: 434  SVVSEPLATL--------VLSHGGHILAS------------------------TSGDSDH 461
                 P  T+        + S G H   S                        T G S  
Sbjct: 998  VASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQ 1057

Query: 462  SPRFS--------------GTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFH 507
              R S              G     SLRL    ++  DSG Y+C+A+N  G+A+     H
Sbjct: 1058 EMRLSVNRLALSKYVWEEYGLLPSGSLRLA--QVQVGDSGHYECTASNPAGSAS-----H 1110

Query: 508  ANAARLLISPAAE-------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH-EGPGSS 559
                 + + P  +       V+ G+A+ L+C +  +P P  + SW  +G +L   GP  S
Sbjct: 1111 RYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEP--QLSWSKDGVVLQGRGPQGS 1168

Query: 560  LLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRR 619
            +   A  ++DAG Y C A   +SA   +    L VL PP      T   L+     AG  
Sbjct: 1169 VHFAAIRTSDAGRYRCEA--SNSAGVDAWEVELRVLEPPHWGADETSGLLERV---AGEN 1223

Query: 620  GLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNP 679
              L C     P  ++      R   +S P  G         P + V +  +L    +   
Sbjct: 1224 ASLPCPARGTPKPQVTW----RKGPSSEPLHG--------QPGVAVLEEGSLFLASVSPA 1271

Query: 680  LLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLT------CNVSR 733
               + G Y C+A+N +G+ S       +A ++   P    ++G +AN++        +  
Sbjct: 1272 ---DSGDYECQATNEVGSTSR------RAKLVVYVPPSIREDGRKANVSGMAGQSLTLEC 1322

Query: 734  EAAGSPA-NFSWFRNGVL---------------WAQ-------GPLETVTLLPVARTDAA 770
            +A G P     W ++  L               W Q          +++    +   D+ 
Sbjct: 1323 DANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSG 1382

Query: 771  LYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALF 830
            LY+CR   +AG       LL VL PP      ++L  G     L +   D       +  
Sbjct: 1383 LYSCRAENQAGTAQRDFHLL-VLTPP------SVLGAGAAQEVLGLAGADVELQCWTSGV 1435

Query: 831  HGEHLLATS-LGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSL 889
                +  T    P +P     Q + +   L++    +G  D G Y+C A +  G      
Sbjct: 1436 PTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSPAGQQARDF 1493

Query: 890  FFQVRGA---W-VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT- 944
              +V      W    +    + E   V L C+   GVP   +  W++DG  L  ST    
Sbjct: 1494 QLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEAR-GVPT-PNITWFKDGALLPTSTKVVY 1551

Query: 945  ------LRFAAITLTQAGAYHCQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP 997
                  L+      + AG Y C+A  A G+A  +    +     Y P  +        G 
Sbjct: 1552 TRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-----YVPPTIE-------GA 1599

Query: 998  GRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGA 1057
            G    ++  V   P A   +  G      +    G P   S    +    + LRLE  G 
Sbjct: 1600 GGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGE 1659

Query: 1058 MLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQL 1117
                 G+Y C AS+  G+A         +V VQV P   V EG L  +T +V    P +L
Sbjct: 1660 A--SSGLYSCVASSPAGEAVLQ-----YSVEVQVPPQLLVAEG-LGQVTTIVG--QPLEL 1709

Query: 1118 ----------TYTWYQDG---------QQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAP 1158
                      T  W Q+G         Q      ++ + +V +  +  + C         
Sbjct: 1710 PCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTA 1769

Query: 1159 RLSRPITLDVLYAPRNLRLT-----YLLESHGGQLALVLCTVDS------RPPAQLALSH 1207
                 +++   +AP  L +      +  E H    A     V        +PP       
Sbjct: 1770 GAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCS 1829

Query: 1208 AGRLLASSTAASVPNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265
             G L    T   V  +L   L++     RDEG Y+C+A +  G++   + L+     V++
Sbjct: 1830 PGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALK-----VLV 1884

Query: 1266 APEA-------AVPEGAPITVTCADPAAHAPTLYTWYHNGR----WLQEGPAASLSFLV- 1313
             P         AV E A +T+ C       P + +W+   +    W+  G   S+   V 
Sbjct: 1885 PPNIEPGPVNKAVLENASVTLECLASGVPPPDV-SWFKGHQPVSSWM--GVTVSVDGRVL 1941

Query: 1314 ----ATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV-IQCT 1368
                A  + AG+Y C A +  G+   R   L+V   P+  +  S       +  V + C 
Sbjct: 1942 RIEQAQLSDAGSYRCVASNVAGSTELR-YGLRVNVPPRITLPPSLPGPVLVNTPVRLTCN 2000

Query: 1369 VDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTA 1427
                P   L    DG  ++ +        GT  +QV      L +    A D   Y C A
Sbjct: 2001 ATGAPSPTLMWLKDGNPVSPA--------GTPGLQVFPGGRVLTLASARASDSGRYSCVA 2052

Query: 1428 QNLLGSISTIGRLQVEGARVVA--EPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWND 1485
             + +G       LQV     +   E  + V    ++ L C+    P PV     +W+ + 
Sbjct: 2053 VSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV----LSWWKDG 2108

Query: 1486 RRLHAEPVPTL----AFTHVARAQ---AGMYHCLAELPTGAAA---SAPVMLRVLYPPKT 1535
            R L   P   L    A   V RA    AG Y C A    G +    +  V +  ++P + 
Sbjct: 2109 RPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRE 2168

Query: 1536 PTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNA 1595
               +   E   G    L C     P   ++           QP         HV A    
Sbjct: 2169 SHTLTVRE---GHPTSLSCECRGVPFPKISWR------KDGQPLPGEGAGLQHVSAVGRL 2219

Query: 1596 LRVDIEALRPSDQGEYICSASNVLGSAS 1623
            L +    L  + +G Y C  SNV+G++S
Sbjct: 2220 LYLGQAQL--AQEGTYTCECSNVVGNSS 2245



 Score =  155 bits (391), Expect = 4e-37
 Identities = 382/1680 (22%), Positives = 579/1680 (34%), Gaps = 292/1680 (17%)

Query: 105  LQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELL--EGTEVDFNCST 162
            +Q  DSG Y+ R E        D    ++T    P V    +  E+L   G +V+  C T
Sbjct: 1376 IQEGDSGLYSCRAENQAGTAQRDFHLLVLT---PPSVLGAGAAQEVLGLAGADVELQCWT 1432

Query: 163  PYVCLQEQVRLQW-QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSV 221
              V   +   ++W + + P      + Q  E   V  +   H+     D GR      S 
Sbjct: 1433 SGVPTPQ---VEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG----DEGRYQCVAFSP 1485

Query: 222  ANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGV 281
            A  +A+ +  L+V +AP  +          ++   LV L C+         +I W KDG 
Sbjct: 1486 AGQQAR-DFQLRV-HAPPTIWGSNETGEVAVMEDHLVQLLCEARGV--PTPNITWFKDGA 1541

Query: 282  RLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPA 333
             L T T V        L L +A  SDAGVYTC+A N VG+       L +++        
Sbjct: 1542 LLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAG 1600

Query: 334  G-----PILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH-------SHTLRLHLAT 381
            G       +  + V L C         L  SW+   + + +++          LRL    
Sbjct: 1601 GRPYVVKAVAGRPVALECVARGHPSPTL--SWHHEGLPVAESNESRLETDGSVLRLESPG 1658

Query: 382  RADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF--LETQAGLVGILHCSVVSEP 439
             A +G Y C   +  G E     SV V  PP   V      + T  G    L C     P
Sbjct: 1659 EASSGLYSCVASSPAG-EAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP 1717

Query: 440  LATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGN 499
            + T+     G      +G    S    GT+      L I  +E   SG + C ATN  G 
Sbjct: 1718 VPTIQWLQNGRPAEELAGVQVAS---QGTT------LHIDHVELDHSGLFACQATNEAGT 1768

Query: 500  ATSTLDFHAN---AARLLISPAAEVVEG----QAVTLSCRS------GLSPTPDARFSWY 546
            A + ++   +   A  +L  P  +   G     +   +C        G  P P     W 
Sbjct: 1769 AGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWC 1828

Query: 547  LNGALLHEGPG--------SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
              G+L  E  G          L +      D G Y C A   + A        L VL PP
Sbjct: 1829 SPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT--NLAGESKREVALKVLVPP 1886

Query: 599  R-QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCG 657
              +P    +  L+ A         L C     PP  +      + V              
Sbjct: 1887 NIEPGPVNKAVLENASV------TLECLASGVPPPDVSWFKGHQPV-------------- 1926

Query: 658  GCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATV---LAIA 714
              S  M VT + +   + I    L + G Y C ASN  G  ST   +  +  V   + + 
Sbjct: 1927 --SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG--STELRYGLRVNVPPRITLP 1982

Query: 715  PS--HTLQEGTEANLTCNVSREAAGSPA-NFSWFRNG--VLWAQGP-------LETVTLL 762
            PS    +   T   LTCN    A G+P+    W ++G  V  A  P          +TL 
Sbjct: 1983 PSLPGPVLVNTPVRLTCN----ATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLA 2038

Query: 763  PVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSR 822
                +D+  Y+C  ++  G      V+L V  PP        + +         C   + 
Sbjct: 2039 SARASDSGRYSCVAVSAVGED-RQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAM 2097

Query: 823  PLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVL 882
            P  +L+ +              P   R      A+   L+V    + D+G Y CEA N  
Sbjct: 2098 PPPVLSWWKDGR----------PLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 2147

Query: 883  GSSNTSLFFQVRGAWV------QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP 936
            G S       V   WV      + S +  ++EG    LSC+   GVP      W +DGQP
Sbjct: 2148 GHSEKHYNLNV---WVAPVFPLRESHTLTVREGHPTSLSCECR-GVP-FPKISWRKDGQP 2202

Query: 937  LQESTSATLRFAAI---------TLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYA-PR 985
            L    +     +A+          L Q G Y C+ +   G+++  L   + +    A PR
Sbjct: 2203 LPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPR 2262

Query: 986  H-VTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVA 1044
               T  +++  G   +  L C     PP  +           T +  G P G+   L + 
Sbjct: 2263 EPPTQVSVVQDG---VATLECNATGKPPPTV-----------TWERDGQPVGAELGLQLQ 2308

Query: 1045 VAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVN 1104
                +L +E   A     G Y C A N  G+A    +     ++V V P        L N
Sbjct: 2309 NQGQSLHVE--RAQAAHTGRYSCVAENLAGRAERKFE-----LSVLVPPELIGDLDPLTN 2361

Query: 1105 LTCLVWTTHPAQL----------TYTWY---------QDGQQRLDAHSIPLPNVTVRDAT 1145
            +T  + +  P  L             W+         +D         + +     +D+ 
Sbjct: 2362 ITAALHS--PLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSG 2419

Query: 1146 SYRCGVGPPGRAPRLSRPITLDVLYAP--RNLRLTYLLESHGGQLALVLCTVDSRPPAQL 1203
             Y C       A    R  +++VL  P   N  L  +++   GQ A ++C V   P  +L
Sbjct: 2420 LYSCLAS--NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL 2477

Query: 1204 ALSHAGRLLASSTAASV-PNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVR 1262
                 GR LA   A  + P+ + L++        G YSC A + +G+     +L      
Sbjct: 2478 TWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQL-----S 2532

Query: 1263 VILAP------------EAAVPEGAPITVTCADPAAHAPTLYTWYHNG------RWLQEG 1304
            V+LAP            E  V    PI++ C   A  +P + TW  +G      R +Q  
Sbjct: 2533 VLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNI-TWMKDGAPFEASRNIQLL 2591

Query: 1305 PAA-SLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP---QDAVLSSFR----D 1356
            P    L  L A +  AG Y+C   +  G  + +   ++VL  P   +D  L         
Sbjct: 2592 PGTHGLQILNAQKEDAGQYTCVVTNELG-EAVKNYHVEVLIPPSISKDDPLGEVGVKEVK 2650

Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416
            ++  S   ++C   + PP  +    DG+ +  SS +  L  G            LQ+Q  
Sbjct: 2651 TKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR----------LLQIQPT 2700

Query: 1417 PAGDD-TYVCTAQNLLGS--------------ISTIGRLQV--------EGARVVAEPGL 1453
               D   Y+C A N+ G                  +G            E AR       
Sbjct: 2701 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 2760

Query: 1454 DVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA-------EPVPTLAFTHVARAQA 1506
            ++ E     L C     P P       W+  D+ L A       +    L    V    A
Sbjct: 2761 EIVENNPAYLYCDTNAIPPP----DLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENA 2816

Query: 1507 GMYHCLAELPTGAAASAPVMLRVLYPP----KTPTMMVFVEPEGGLRGILDCRVDSEPLA 1562
            G Y C A    G       +L VL PP     T  ++  V         L C     P+ 
Sbjct: 2817 GRYSCKASNEVGEDWLHYELL-VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVP 2875

Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
            ++          S    G P  P   +    +   + +     +D   Y+C A N  GSA
Sbjct: 2876 TI----------SWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA 2925



 Score =  148 bits (374), Expect = 4e-35
 Identities = 309/1299 (23%), Positives = 445/1299 (34%), Gaps = 234/1299 (18%)

Query: 251  NILPGELVTLTCQVNSSYPAVSSIKWLKDG----------VRLQTKTGVLHLPQAAWSDA 300
            ++L G+ V L C+ +   P    + WLKDG          +R     G L L     SDA
Sbjct: 3228 HVLEGQEVRLDCEADGQPPP--DVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA 3285

Query: 301  GVYTCQAENGVGS---------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNE 351
            G YTC A N  G          LV P I      +   VS  G +     VT+VC     
Sbjct: 3286 GAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGEL-----VTMVCPVRGS 3340

Query: 352  APSDLRYSWYKNHVLLE-------DAHSHTLRLHLATRADTGFYFCEVQNVHG-SERSGP 403
             P  +  SW K+ + L            HTLR+     AD G + C   +  G ++R+  
Sbjct: 3341 PP--IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFT 3398

Query: 404  VSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP 463
            + V V  P L PV     E Q  +V      VV   L  L     G  L   S   D  P
Sbjct: 3399 LQVQVP-PVLEPV-----EFQNDVV------VVRGSLVELPCEARGVPLPLVSWMKDGEP 3446

Query: 464  RFSGT--SGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEV 521
              S +   GP+   L++  +   DSG Y C A +  G A             ++ P    
Sbjct: 3447 LLSQSLEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQL------TVMEPPHIE 3497

Query: 522  VEGQAVTLSCRSGL--------SPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSY 573
              GQ   LS   G           TP    +W+ +G  L     +S         DAG Y
Sbjct: 3498 DSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLY 3557

Query: 574  HCRARDGHSASGPSSPAVLTV---LYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDP 630
             C A     A   S    +     +  PR P F   L        A  + +L C V+++P
Sbjct: 3558 TCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGL--------APGQLVLECSVEAEP 3609

Query: 631  PARLQLLHKDRVVA-----TSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685
              ++   H+D +V      T  P  G                      +++      + G
Sbjct: 3610 APKITW-HRDGIVLQEDAHTQFPERGRF--------------------LQLQALSTADSG 3648

Query: 686  LYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANF-SW 744
             Y C A NA G  STS  F  +   +    S         N T  +  +A G PA   SW
Sbjct: 3649 DYSCTARNAAG--STSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSW 3706

Query: 745  FRNGV-------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPD 797
             ++ V        +   P  ++ + PV   DA  Y C     AG+      L  VL PP 
Sbjct: 3707 RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDL-RVLEPPA 3765

Query: 798  RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEAN 857
                 + L +     AL  C     P  L+  +     L   L       G ++    +N
Sbjct: 3766 IAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL-----QQGAYRL-LPSN 3819

Query: 858  SLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQA------ 911
            +L L     G  DS  + C  +N +G ++       R   V V   P + + Q       
Sbjct: 3820 ALLLTAP--GPQDSAQFECVVSNEVGEAH-------RLYQVTVHVPPTIADDQTDFTVTM 3870

Query: 912  ---VVLSCQVHTGVPEGTSYRWYRDGQPL-------QESTSATLRFAAITLTQAGAYHCQ 961
               VVL+C   TG+P  T   W + G  L       + S S  L         AG Y C 
Sbjct: 3871 MAPVVLTCH-STGIPAPT-VSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCS 3928

Query: 962  AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGD 1021
            A+            + L V  +P    L +++        LL C     P   +      
Sbjct: 3929 ARNSAGVAHK---HVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG 3985

Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081
              VA+ +     P G              +L I  A  ED G Y+C A N+ G A     
Sbjct: 3986 LNVATGVSTQVLPGG--------------QLRIAHASPEDAGNYLCIAKNSAGSAMGKTR 4031

Query: 1082 FDAQAVNV--QVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS------ 1133
               Q   V     P  +  EG    L C    +    +T  W +DGQ    A        
Sbjct: 4032 LVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNIT--WDKDGQPVSGAEGKFTIQP 4089

Query: 1134 ---IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAP--------RNLRLTYLL- 1181
               + + N+  +DA +Y C         R  R + L +L  P        R+LRL   L 
Sbjct: 4090 SGELLVKNLEGQDAGTYTCTA--ENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLW 4147

Query: 1182 ---ESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGF 1238
                + G     +  TV+ RP  +      G       A S               D G 
Sbjct: 4148 LRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVS-------------REDSGT 4194

Query: 1239 YSCSARSPLGQANTSLELRLEGVRVILAPEAAV---PEGAPITVTCADPAAHAPTLYTWY 1295
            Y C A + +G+      + ++   V+     +    P G  I + C       P ++ W 
Sbjct: 4195 YVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIH-WI 4253

Query: 1296 HNG---------RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP 1346
             +G           LQ G   SL+     R  AG Y C A++  G  + +   L +  AP
Sbjct: 4254 KDGLPLRGSHLRHQLQNG---SLTIHRTERDDAGRYQCLAENEMGV-AKKVVILVLQSAP 4309

Query: 1347 QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVAR 1406
               V       R+     ++C    EP   +     G+ L  S  + +L  G+       
Sbjct: 4310 VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGS------- 4362

Query: 1407 NALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQVEG 1444
                L +++V  GD  TY C A NLLGS +    L V G
Sbjct: 4363 ----LWLENVETGDAGTYDCVAHNLLGSATARAFLVVRG 4397



 Score =  145 bits (365), Expect = 4e-34
 Identities = 291/1244 (23%), Positives = 437/1244 (35%), Gaps = 225/1244 (18%)

Query: 477  EIRDLEETDSGEYKCSATN--SLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSG 534
            EI    + + G Y+C+A +    G A + +       +L+ +P   V  G+   LSCR  
Sbjct: 482  EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRV- 540

Query: 535  LSPTPDARFSWYLNGALLHEGPGS-------SLLLPAASSTDAGSYHCRARDGHSASGPS 587
            L   P    +W  +  +L    G        SL +     TD G Y C A +   A+G +
Sbjct: 541  LGEAP-YNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN---ANGVT 596

Query: 588  SPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSL 647
              +V  ++    Q +  T     + G        + C     P   +    + + +    
Sbjct: 597  RASVWLLVREAPQVSIHTSSQHFSQGVEVK----VSCSASGYPTPHISWSRESQALQED- 651

Query: 648  PSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSAT--FN 705
                          R+ V     L+   I     E+ G Y C+A+N +G    + T  + 
Sbjct: 652  -------------SRIHVDAQGTLI---IQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 695

Query: 706  GQATVLAIAPSHTLQEGTEANLTCNVSREAAG-SPANFSWFRNG---VLWAQGPLETVTL 761
               +V A+     +  G EA L C    EA+G  P    W+R G   +L  +G       
Sbjct: 696  DPPSVSAVNAVVLVAVGEEAVLVC----EASGVPPPRVIWYRGGLEMILAPEGSSSGKLR 751

Query: 762  LPVART-DAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVD 820
            +P A+  DA  Y CR + E G   S  + L+V + P   +L   + +  G  AL  C   
Sbjct: 752  IPAAQERDAGTYTCRAVNELG-DASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRAT 810

Query: 821  SRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATN 880
             RP   +    G+      LG ++ + GR     + +S  L    +   D   Y CEA N
Sbjct: 811  GRPPPTVTWRRGD---GQPLGLRLGA-GRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 866

Query: 881  VLGSSNTSLFFQVRG-AWVQVS---PSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP 936
            V G         V G A  Q++   P+  + EGQ V L C V  G P    + W +DG+P
Sbjct: 867  VFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH-WLKDGRP 925

Query: 937  LQESTSATLRF-AAITLTQA-----GAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLT 990
            L   +  ++R   ++ L +A     G Y C A    +   S    + L V   PR     
Sbjct: 926  LPPGSRHSIRADGSLHLDRALQEHAGRYSCVAT---NTAGSQHRDVELVVQVPPRIHPTA 982

Query: 991  TLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTL 1050
            T   T  G    L C     P   +        + S            P  +V+     L
Sbjct: 983  THHITNEGVPASLPCVASGVPAPTITWTKETNALTSR----------GPHYNVSKEGTLL 1032

Query: 1051 RLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVW 1110
               I     +D G Y+C A+NT+G       F +Q + + V                   
Sbjct: 1033 ---IAQPSAQDAGAYVCTATNTVG-------FSSQEMRLSV------------------- 1063

Query: 1111 TTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLY 1170
                A   Y W + G   L + S+ L  V V D+  Y C    P  A   S    L V  
Sbjct: 1064 -NRLALSKYVWEEYGL--LPSGSLRLAQVQVGDSGHYECTASNP--AGSASHRYVLGVQV 1118

Query: 1171 APRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRG 1230
             P+      +L+   G+   + C  +  P  QL+ S  G +L                RG
Sbjct: 1119 PPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQG--------------RG 1164

Query: 1231 PQ---------PRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTC 1281
            PQ           D G Y C A +  G     +ELR     V+  P     E + +    
Sbjct: 1165 PQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELR-----VLEPPHWGADETSGLLERV 1219

Query: 1282 AD-------PAAHAPTLYTWYHNG------------RWLQEGPAASLSFLVATRAHAGAY 1322
            A        PA   P     +  G              L+EG   SL     + A +G Y
Sbjct: 1220 AGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEG---SLFLASVSPADSGDY 1276

Query: 1323 SCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMA----VIQCTVDSEPPAELA 1378
             CQA +  G+ S R  A  V+Y P  ++    R +    MA     ++C  +  P  E+ 
Sbjct: 1277 ECQATNEVGSTSRR--AKLVVYVPP-SIREDGRKANVSGMAGQSLTLECDANGFPVPEIV 1333

Query: 1379 LSHDGKVLATSSGVHSLASGTGHVQVARNAL-----RLQVQDVPAGDD-TYVCTAQNLLG 1432
               D +++    G        G  QV  + L      L    +  GD   Y C A+N  G
Sbjct: 1334 WLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG 1393

Query: 1433 SISTIGRL------QVEGARVVAEP-GLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWND 1485
            +      L       V GA    E  GL    GA + L C   G P P         W  
Sbjct: 1394 TAQRDFHLLVLTPPSVLGAGAAQEVLGL---AGADVELQCWTSGVPTPQVE------WTK 1444

Query: 1486 RRLHAEP------------VPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPP 1533
             R    P            V  +  +HV     G Y C+A  P G  A     LRV  PP
Sbjct: 1445 DRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSPAGQQAR-DFQLRVHAPP 1501

Query: 1534 KTPTMMVFVEPEGGLRGILD-------CRVDSEPLASLTLHLGSRLVASSQPQGAPAEPH 1586
                  ++   E G   +++       C     P  ++T      L+ +S          
Sbjct: 1502 T-----IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTK-------- 1548

Query: 1587 IHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGV 1630
              V+ +    ++ +   + SD G Y C ASN +G+A  +T   V
Sbjct: 1549 --VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 1590



 Score =  144 bits (362), Expect = 1e-33
 Identities = 356/1523 (23%), Positives = 529/1523 (34%), Gaps = 293/1523 (19%)

Query: 250  RNILPGELVTLTCQVNSSYPAVSSIKWLK--------DGVRLQTKTGVLHLPQAAWSDAG 301
            R I+      L C  N+  P    + W +        D V +     VL +P     +AG
Sbjct: 2760 REIVENNPAYLYCDTNAIPPP--DLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAG 2817

Query: 302  VYTCQAENGVGS--------LVSPPISL---HIFMAEVQVSPAGPILENQTVTLVCNT-P 349
             Y+C+A N VG         +++PP+ L      + EV V+ +       TV+L C    
Sbjct: 2818 RYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS------TVSLQCPALG 2871

Query: 350  NEAPSDLRYSWYKNHV---------LLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSER 400
            N  P+    SW +N +         +LED     L++  A  AD   Y C  +N  GS  
Sbjct: 2872 NPVPT---ISWLQNGLPFSPSPRLQVLEDGQ--VLQVSTAEVADAASYMCVAENQAGSAE 2926

Query: 401  SGPVSVVVNHPPLTPVL-----TAFLETQAGLVGILHCSVVSEPL---ATLVLSHGGHIL 452
                ++ V  PP    L     TA L +   L   +H     E      +  LS G  + 
Sbjct: 2927 K-LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVF 2985

Query: 453  ASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR 512
                              P +  L++     +DSG Y C A N+ G     +        
Sbjct: 2986 LL----------------PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLS----- 3024

Query: 513  LLISPAAE-----------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP----- 556
            +L+ PA             V  G    LSC +   P P    +WY +G  L         
Sbjct: 3025 VLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTV--TWYKDGQPLVLAQRTQAL 3082

Query: 557  --GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGA 614
              G  L +  A  +D G Y C+    + A        LTV  PP      T      AG+
Sbjct: 3083 RGGQRLEIQEAQVSDKGLYSCKV--SNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGS 3140

Query: 615  GAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRV 674
                  +L C V   P   +  L KDR+   S    G  S  G               R+
Sbjct: 3141 PL----VLTCDVSGVPAPTVTWL-KDRMPVESSAVHGVVSRGG---------------RL 3180

Query: 675  EIHNPLLEEEGLYLCEASNALGNAS----TSATFNGQATVLAIAPSHTLQEGTEANLTCN 730
            ++      + G Y C A N    A      +     +     +A  H + EG E  L C 
Sbjct: 3181 QLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC- 3239

Query: 731  VSREAAGSPA-NFSWFRNGVLWAQ--GPL-------ETVTLLPVARTDAALYACRILTEA 780
               EA G P  + +W ++G    Q  GP         ++ L  +  +DA  Y C     A
Sbjct: 3240 ---EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPA 3296

Query: 781  G--AQLSTPVLLSVLYPPDRPKL---SALLDMGQGHMALFICTV-DSRPLALLALFHGEH 834
            G  A+L T   ++VL PP   +    S  L    G +   +C V  S P+ +  L  G  
Sbjct: 3297 GEDARLHT---VNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDG-- 3351

Query: 835  LLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894
             L   L  +   HG        +   L + ++ L D+G + C A +  G ++ +   QV 
Sbjct: 3352 -LPLPLSQRTLLHG--------SGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV- 3401

Query: 895  GAWVQVSPSPELQE---------GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST---S 942
                QV P  E  E         G  V L C+   GVP      W +DG+PL   +    
Sbjct: 3402 ----QVPPVLEPVEFQNDVVVVRGSLVELPCEAR-GVPLPL-VSWMKDGEPLLSQSLEQG 3455

Query: 943  ATLRFAAITLTQAGAYHCQA-----QAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP 997
             +L+  A+    +G Y C A     +A      ++  P  +  S  P  ++LT      P
Sbjct: 3456 PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLT------P 3509

Query: 998  GRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGA 1057
            G    LLC     P   +   H D    + L+            + + A   LR+     
Sbjct: 3510 GAPMELLCDAQGTPQPNITW-HKDGQALTRLE------------NNSRATRVLRVR---- 3552

Query: 1058 MLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGAT-----VREGQLVNLTCLVWTT 1112
               D G+Y C A +  G    S     QA    V P        +  GQLV L C V   
Sbjct: 3553 ---DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSV-EA 3607

Query: 1113 HPAQLTYTWYQDG-QQRLDAHS--------IPLPNVTVRDATSYRC----GVGPPGRAPR 1159
             PA    TW++DG   + DAH+        + L  ++  D+  Y C      G    A R
Sbjct: 3608 EPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 3666

Query: 1160 LSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGR--LLASSTA 1217
            +       +   P  + ++        Q AL+ C  D   PA L      R  L   S  
Sbjct: 3667 VEIHTVPTIRSGPPAVNVSV------NQTALLPCQADG-VPAPLVSWRKDRVPLDPRSPR 3719

Query: 1218 ASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPI 1277
              +     L ++    +D G Y C A +  G      +LR      +L P A  P  + +
Sbjct: 3720 FEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR------VLEPPAIAPSPSNL 3773

Query: 1278 TVTCADPA-------AHAPTLYTWYHNGRWL----QEG-----PAASLSFLVATRAHAGA 1321
            T+T   PA            L  W+ +G+ L    Q+G     P+ +L         +  
Sbjct: 3774 TLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQ 3833

Query: 1322 YSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMA--VIQCTVDSEPPAELAL 1379
            + C   +  G         QV       +     D     MA  V+ C     P   ++ 
Sbjct: 3834 FECVVSNEVGEAHR---LYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSW 3890

Query: 1380 SHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGR 1439
            S  G  L         A G+G+      AL +  Q +P     Y C+A+N  G       
Sbjct: 3891 SKAGAQLG--------ARGSGYRVSPSGALEIG-QALPIHAGRYTCSARNSAGVAHKHVF 3941

Query: 1440 LQVEGARVVAEPGLDVPEGAA---LNLSCRLLGGPGPVGNSTFAWFWNDRRL------HA 1490
            L V+ + VV +P   V    A   + L C   G P P    T  W      +        
Sbjct: 3942 LTVQASPVV-KPLPSVVRAVAEEEVLLPCEASGIPRP----TITWQKEGLNVATGVSTQV 3996

Query: 1491 EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRG 1550
             P   L   H +   AG Y C+A+   G+A      L V  PP     +  +    G   
Sbjct: 3997 LPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGK-TRLVVQVPPVIENGLPDLSTTEGSHA 4055

Query: 1551 ILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGE 1610
             L C+    P  ++T     + V+        AE    +  S   L   ++ L   D G 
Sbjct: 4056 FLPCKARGSPEPNITWDKDGQPVSG-------AEGKFTIQPSGELL---VKNLEGQDAGT 4105

Query: 1611 YICSASNVLGSASTSTYFGVRAL 1633
            Y C+A N +G A    +  +  L
Sbjct: 4106 YTCTAENAVGRARRRVHLTILVL 4128



 Score =  140 bits (353), Expect = 1e-32
 Identities = 212/859 (24%), Positives = 310/859 (36%), Gaps = 135/859 (15%)

Query: 855  EANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPE--LQEGQAV 912
            E+ +   E+      + G+Y C A +  G+        V     Q+ P+P   +  G+  
Sbjct: 475  ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETA 534

Query: 913  VLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITL-------TQAGAYHCQAQAP 965
            VLSC+V    P   +  W RD + L  ST    + A ++L       T  G Y C A   
Sbjct: 535  VLSCRVLGEAPYNLT--WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA 592

Query: 966  GSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVA 1025
               T    A + L V  AP+    T+      G    + C     P   +      + + 
Sbjct: 593  NGVT---RASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ 649

Query: 1026 STLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF--- 1082
                          R+HV        L I G   ED G Y C+A+N +G    +      
Sbjct: 650  -----------EDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 695

Query: 1083 ---DAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL------DAHS 1133
                  AVN  V     V  G+   L C      P ++   WY+ G + +       +  
Sbjct: 696  DPPSVSAVNAVV----LVAVGEEAVLVCEASGVPPPRV--IWYRGGLEMILAPEGSSSGK 749

Query: 1134 IPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVL 1192
            + +P    RDA +Y C  V   G A   S  I L V +AP+   L   +    G+ AL+ 
Sbjct: 750  LRIPAAQERDAGTYTCRAVNELGDA---SAEIQLAVGHAPQLTELPRDVTVELGRSALLA 806

Query: 1193 CTVDSRPPAQLALSHAG------RLLASSTAAS-VPNTLRLELRGPQPRDEGFYSCSARS 1245
            C    RPP  +            RL A   + S  P++  L      P D+  Y C AR+
Sbjct: 807  CRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 866

Query: 1246 PLGQANTSLELRLEGVR----VILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWL 1301
              G+      L + G         AP   V EG P+++ C   A        W  +GR L
Sbjct: 867  VFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPL 926

Query: 1302 QEGPA------ASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR 1355
              G         SL    A + HAG YSC A +  G++  R   L V   P+    ++  
Sbjct: 927  PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQ-HRDVELVVQVPPRIHPTATHH 985

Query: 1356 DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR----- 1410
             +     A + C     P   +  + +   L TS G H   S  G + +A+ + +     
Sbjct: 986  ITNEGVPASLPCVASGVPAPTITWTKETNAL-TSRGPHYNVSKEGTLLIAQPSAQDAGAY 1044

Query: 1411 ---------------------------------------LQVQDVPAGDD-TYVCTAQNL 1430
                                                   L++  V  GD   Y CTA N 
Sbjct: 1045 VCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNP 1104

Query: 1431 LGSISTIGRLQVEGARVVAEPG---LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRR 1487
             GS S    L V+    V +PG   L V  G AL+L+C   G P P      +W  +   
Sbjct: 1105 AGSASHRYVLGVQVPPQV-QPGPRVLKVLVGEALDLNCVAEGNPEP----QLSWSKDGVV 1159

Query: 1488 LHAE-PVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPK--TPTMMVFVEP 1544
            L    P  ++ F  +  + AG Y C A    G  A   V LRVL PP          +E 
Sbjct: 1160 LQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVDA-WEVELRVLEPPHWGADETSGLLER 1218

Query: 1545 EGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALR 1604
              G    L C     P   +T   G     SS+P     +P + VL   +     + ++ 
Sbjct: 1219 VAGENASLPCPARGTPKPQVTWRKG----PSSEP--LHGQPGVAVLEEGSLF---LASVS 1269

Query: 1605 PSDQGEYICSASNVLGSAS 1623
            P+D G+Y C A+N +GS S
Sbjct: 1270 PADSGDYECQATNEVGSTS 1288



 Score =  130 bits (327), Expect = 1e-29
 Identities = 316/1405 (22%), Positives = 475/1405 (33%), Gaps = 267/1405 (19%)

Query: 380  ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEP 439
            A++A+ G Y C   +  G+ R+    +VV  PP   V    +    G   +L C V+ E 
Sbjct: 486  ASKAEEGTYECTAVSRAGTGRA-KAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA 544

Query: 440  LATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG- 498
               L       +L +++G           +    L LEI  +  TD G Y+C A+N+ G 
Sbjct: 545  PYNLTWVRDWRVLPASTG---------RVAQLADLSLEISGIIPTDGGRYQCVASNANGV 595

Query: 499  NATSTLDFHANAARLLISPAAE-VVEGQAVTLSCRSGLSPTPDARFSWYLNGALL----- 552
               S       A ++ I  +++   +G  V +SC +   PTP    SW      L     
Sbjct: 596  TRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTP--HISWSRESQALQEDSR 653

Query: 553  -HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDA 611
             H     +L++   +  DAG+Y C+A    +  G     V      P   +    + L A
Sbjct: 654  IHVDAQGTLIIQGVAPEDAGNYSCQAT---NEVGTDQETVTLYYTDPPSVSAVNAVVLVA 710

Query: 612  AGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNL 671
             G  A    +L+C     PP R+ + ++  +     P G         S ++++  A   
Sbjct: 711  VGEEA----VLVCEASGVPPPRV-IWYRGGLEMILAPEGSS-------SGKLRIPAAQE- 757

Query: 672  LRVEIHNPLLEEEGLYLCEASNALGNASTSATFN-GQATVLAIAPSH-TLQEGTEANLTC 729
                       + G Y C A N LG+AS       G A  L   P   T++ G  A L C
Sbjct: 758  ----------RDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLAC 807

Query: 730  NVSREAAGSPANFSWFR-------------NGVLWAQGPLETVTLLPVARTDAALYACRI 776
               R     P   +W R              G    Q     +    VA  D A Y C  
Sbjct: 808  ---RATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEA 864

Query: 777  LTEAG-AQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTV-DSRPLALLALFHGEH 834
                G  Q    ++++   PP     +  + + +G      C V   RPL         H
Sbjct: 865  RNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLP------ERH 918

Query: 835  LLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSS--NTSLFFQ 892
             L    G  +P   R   +A+ +   L +       +G Y C ATN  GS   +  L  Q
Sbjct: 919  WLKD--GRPLPPGSRHSIRADGS---LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ 973

Query: 893  VRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRD-------GQPLQESTSATL 945
            V       +      EG    L C V +GVP  T   W ++       G     S   TL
Sbjct: 974  VPPRIHPTATHHITNEGVPASLPC-VASGVPAPT-ITWTKETNALTSRGPHYNVSKEGTL 1031

Query: 946  RFAAITLTQAGAYHCQA--------QAPGSATTSLAAPISLHVSYA-------------- 983
              A  +   AGAY C A        Q    +   LA    +   Y               
Sbjct: 1032 LIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQV 1091

Query: 984  --PRHVTLTTLMDTGPGR----LGLLLCRVDSDPPAQLRLLHGDRL-VASTLQGVGGPEG 1036
                H   T     G       LG+ +       P  L++L G+ L +    +G   P+ 
Sbjct: 1092 GDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQL 1151

Query: 1037 SSPRLHVAVAPNTLRLEIHGAML--EDEGVYICEASNTLGQASASADFDAQAVNVQV--- 1091
            S  +  V +     +  +H A +   D G Y CEASN       SA  DA  V ++V   
Sbjct: 1152 SWSKDGVVLQGRGPQGSVHFAAIRTSDAGRYRCEASN-------SAGVDAWEVELRVLEP 1204

Query: 1092 --WPGATVREGQL-------VNLTCLVWTTHPAQLTY--------TWYQDGQQRLDAHSI 1134
              W GA    G L        +L C    T   Q+T+           Q G   L+  S+
Sbjct: 1205 PHW-GADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSL 1263

Query: 1135 PLPNVTVRDATSYRC----GVGPPGRAPRLSRPITLDVLYAPRNLR---LTYLLESHGGQ 1187
             L +V+  D+  Y C     VG   R  +L       V+Y P ++R       +    GQ
Sbjct: 1264 FLASVSPADSGDYECQATNEVGSTSRRAKL-------VVYVPPSIREDGRKANVSGMAGQ 1316

Query: 1188 LALVLCTVDSRPPAQLA-----------LSHAG-------------RLLASSTAASVPNT 1223
               + C  +  P  ++            L  AG             RLL    +   P  
Sbjct: 1317 SLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRI 1376

Query: 1224 LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVP----EGAPITV 1279
                    Q  D G YSC A +  G A     L +     +L   AA       GA + +
Sbjct: 1377 --------QEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVEL 1428

Query: 1280 TCADPAAHAPTLYTWYHNGRWLQEGPAASL----SFLVATRAHA---GAYSCQAQDAQGT 1332
             C       P +         L  GP   +      L  T +H    G Y C A    G 
Sbjct: 1429 QCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAG- 1487

Query: 1333 RSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQ-------CTVDSEPPAELALSHDGKV 1385
            + +R   L+V   P     + +  +    +AV++       C     P   +    DG +
Sbjct: 1488 QQARDFQLRVHAPP-----TIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGAL 1542

Query: 1386 LATSSGVHSLASGTGHVQVARNALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQVEG 1444
            L TS+           V   R   +LQ+    + D   Y C A N +G+     RL V  
Sbjct: 1543 LPTST----------KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV 1592

Query: 1445 ARVVAEPG-----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFW--------NDRRLHAE 1491
               +   G     +    G  + L C   G P P    T +W          N+ RL  +
Sbjct: 1593 PPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP----TLSWHHEGLPVAESNESRLETD 1648

Query: 1492 PVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI 1551
                L       A +G+Y C+A  P G A     +L+     + P  ++  E  G +  I
Sbjct: 1649 G-SVLRLESPGEASSGLYSCVASSPAGEA-----VLQYSVEVQVPPQLLVAEGLGQVTTI 1702

Query: 1552 ------LDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRP 1605
                  L C+    P+ ++               G PAE    V  +     + I+ +  
Sbjct: 1703 VGQPLELPCQASGSPVPTI----------QWLQNGRPAEELAGVQVASQGTTLHIDHVEL 1752

Query: 1606 SDQGEYICSASNVLGSASTSTYFGV 1630
               G + C A+N  G+A       V
Sbjct: 1753 DHSGLFACQATNEAGTAGAEVEVSV 1777



 Score =  124 bits (311), Expect = 8e-28
 Identities = 263/1141 (23%), Positives = 402/1141 (35%), Gaps = 168/1141 (14%)

Query: 188  SQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSP 247
            SQ+    G GH  TL ++        I  C  +     A     LQV+  P    +L   
Sbjct: 3357 SQRTLLHGSGH--TLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPP----VLEPV 3410

Query: 248  SGRN---ILPGELVTLTCQVNS-SYPAVSSIKWLKDGVRLQTKT----GVLHLPQAAWSD 299
              +N   ++ G LV L C+      P VS   W+KDG  L +++      L L      D
Sbjct: 3411 EFQNDVVVVRGSLVELPCEARGVPLPLVS---WMKDGEPLLSQSLEQGPSLQLEAVGAGD 3467

Query: 300  AGVYTCQAENGVG--------SLVSPPISLHIFMA----EVQVSPAGPILENQTVTLVCN 347
            +G Y+C A +  G        +++ PP   HI  +    E+ ++P  P+       L+C+
Sbjct: 3468 SGTYSCVAVSEAGEARRHFQLTVMEPP---HIEDSGQPTELSLTPGAPM------ELLCD 3518

Query: 348  TPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGS-ERSGPVSV 406
                   ++  +W+K+   L    +++    +    D G Y C  ++  G+ E+S  V V
Sbjct: 3519 AQGTPQPNI--TWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRV 3576

Query: 407  VVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466
                  + P    F+   A    +L CSV +EP   +     G +L   +          
Sbjct: 3577 QAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAH--------- 3627

Query: 467  GTSGPNSLR-LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLIS--PAAEVVE 523
             T  P   R L+++ L   DSG+Y C+A N+ G+ +       +    + S  PA  V  
Sbjct: 3628 -TQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSV 3686

Query: 524  GQAVTLSCRSGLSPTPDARFSWYLNGALLHEG-------PGSSLLLPAASSTDAGSYHCR 576
             Q   L C++   P P    SW  +   L          P  SL +    + DAG Y C 
Sbjct: 3687 NQTALLPCQADGVPAP--LVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCL 3744

Query: 577  ARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQL 636
            A   +SA        L VL PP      + L L A         LL C     P   +  
Sbjct: 3745 A--SNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPA-----LLPCEASGSPKPLVVW 3797

Query: 637  LHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG 696
                + +   L  G             ++  +  LL   +  P  ++   + C  SN +G
Sbjct: 3798 WKDGQKLDFRLQQGA-----------YRLLPSNALL---LTAPGPQDSAQFECVVSNEVG 3843

Query: 697  NAST--SATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNGV---- 749
             A      T +   T+       T+       LTC+    + G PA   SW + G     
Sbjct: 3844 EAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCH----STGIPAPTVSWSKAGAQLGA 3899

Query: 750  ------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSA 803
                  +   G LE    LP+    A  Y C     AG      V L+V   P    L +
Sbjct: 3900 RGSGYRVSPSGALEIGQALPI---HAGRYTCSARNSAGVA-HKHVFLTVQASPVVKPLPS 3955

Query: 804  LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
            ++        L  C     P   +        +AT +  QV   G+           L +
Sbjct: 3956 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ-----------LRI 4004

Query: 864  RELGLGDSGSYRCEATNVLGSS--NTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTG 921
                  D+G+Y C A N  GS+   T L  QV        P     EG    L C+   G
Sbjct: 4005 AHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKAR-G 4063

Query: 922  VPEGTSYRWYRDGQPLQEST-------SATLRFAAITLTQAGAYHCQAQAPGSATTSLAA 974
             PE  +  W +DGQP+  +        S  L    +    AG Y C A+   +A      
Sbjct: 4064 SPE-PNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAE---NAVGRARR 4119

Query: 975  PISLHVSYAPRHVTLTTLMDTGPGRLG---LLLCRVDSDPPAQLRLLHGDRLVASTLQGV 1031
             + L +   P     TTL      RLG    L C     P  ++     DR V    +GV
Sbjct: 4120 RVHLTILVLP---VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT---EGV 4173

Query: 1032 GGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF---DAQAVN 1088
               +G S     AV+             ED G Y+C A N +G+  A +     +A  + 
Sbjct: 4174 SEQDGGSTLQRAAVSR------------EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQ 4221

Query: 1089 VQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDG--------QQRLDAHSIPLPNVT 1140
             + +       G  + L C+V       +   W +DG        + +L   S+ +    
Sbjct: 4222 GEAFSYLVEPVGGSIQLDCVVRGDPVPDIH--WIKDGLPLRGSHLRHQLQNGSLTIHRTE 4279

Query: 1141 VRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRP 1199
              DA  Y+C      G A ++   + L +  AP        +    G    + C     P
Sbjct: 4280 RDDAGRYQCLAENEMGVAKKV---VILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEP 4336

Query: 1200 PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE 1259
               +    AG+ L +S          L L   +  D G Y C A + LG A     L + 
Sbjct: 4337 TPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 4396

Query: 1260 G 1260
            G
Sbjct: 4397 G 4397



 Score =  108 bits (271), Expect = 3e-23
 Identities = 163/663 (24%), Positives = 244/663 (36%), Gaps = 72/663 (10%)

Query: 1002 LLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061
            L+ C V S  P +L+L  G+  +                 H   + N+   EI  A   +
Sbjct: 445  LVSCSVHSALPFRLQLRRGEARLGE-------------ERHFQESGNS-SWEILRASKAE 490

Query: 1062 EGVYICEASNTLGQASASADFDAQAVNVQVWPG--ATVREGQLVNLTCLVWTTHPAQLTY 1119
            EG Y C A +  G   A A         Q+ P    TV  G+   L+C V    P  LT 
Sbjct: 491  EGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT- 549

Query: 1120 TWYQDGQ---------QRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLY 1170
             W +D +          +L   S+ +  +   D   Y+C         R S  + L V  
Sbjct: 550  -WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS--VWLLVRE 606

Query: 1171 APRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRG 1230
            AP+    T       G    V C+    P   ++ S   + L   +   V     L ++G
Sbjct: 607  APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQG 666

Query: 1231 PQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAA--VPEGAPITVTCADPAAHA 1288
              P D G YSC A + +G    ++ L       + A  A   V  G    + C + +   
Sbjct: 667  VAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC-EASGVP 725

Query: 1289 PTLYTWYHNGRWLQEGPAAS----LSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLY 1344
            P    WY  G  +   P  S    L    A    AG Y+C+A +  G  S+    L V +
Sbjct: 726  PPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE-IQLAVGH 784

Query: 1345 APQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSH-DGKVLATSSGVHSLASGTGHVQ 1403
            APQ   L           A++ C     PP  +     DG+ L        L +G G   
Sbjct: 785  APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL-----RLGAGRGSRS 839

Query: 1404 VARNALRLQVQDV-PAGDDTYVCTAQNLLGSISTIGRLQVEGAR----VVAEPGLDVPEG 1458
               ++  L  + V P     YVC A+N+ G +    RL V G        + P + V EG
Sbjct: 840  RQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEG 899

Query: 1459 AALNLSCRLLGG-PGPVGNSTFAWFWNDRRL---HAEPVPTLAFTHVARA---QAGMYHC 1511
              ++L C +L G P P  +    W  + R L       +      H+ RA    AG Y C
Sbjct: 900  QPVSLPCIVLAGRPLPERH----WLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSC 955

Query: 1512 LAELPTGAAASAPVMLRVLYPPKT-PTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGS 1570
            +A   T  +    V L V  PP+  PT    +  E G+   L C     P  ++T    +
Sbjct: 956  VA-TNTAGSQHRDVELVVQVPPRIHPTATHHITNE-GVPASLPCVASGVPAPTITWTKET 1013

Query: 1571 RLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGV 1630
              + S  P    ++    ++A P+A           D G Y+C+A+N +G +S      V
Sbjct: 1014 NALTSRGPHYNVSKEGTLLIAQPSA----------QDAGAYVCTATNTVGFSSQEMRLSV 1063

Query: 1631 RAL 1633
              L
Sbjct: 1064 NRL 1066



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 116/457 (25%), Positives = 168/457 (36%), Gaps = 52/457 (11%)

Query: 1187 QLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSA--R 1244
            Q  LV C+V S  P +L L      L              E+      +EG Y C+A  R
Sbjct: 442  QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSR 501

Query: 1245 SPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWL--Q 1302
            +  G+A   + +     +++ AP   V  G    ++C      AP   TW  + R L   
Sbjct: 502  AGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR-VLGEAPYNLTWVRDWRVLPAS 560

Query: 1303 EGPAASLSFLV-----ATRAHAGAYSCQAQDAQG-TRSSRPAALQVLYAPQDAVLSSFRD 1356
             G  A L+ L            G Y C A +A G TR+S    L V  APQ ++ +S + 
Sbjct: 561  TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS--VWLLVREAPQVSIHTSSQH 618

Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416
                    + C+    P   ++ S + + L   S +H  A GT           L +Q V
Sbjct: 619  FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT-----------LIIQGV 667

Query: 1417 -PAGDDTYVCTAQNLLGS-ISTIGRLQVEGARVVAEPGLD-VPEGAALNLSCRLLGGPGP 1473
             P     Y C A N +G+   T+     +   V A   +  V  G    L C   G P P
Sbjct: 668  APEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPP 727

Query: 1474 VGNSTFAWFWNDRRLHAEPVPT----LAFTHVARAQAGMYHCLAELPTGAAASAPVMLRV 1529
                   W+     +   P  +    L         AG Y C A    G  ASA + L V
Sbjct: 728  ----RVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELG-DASAEIQLAV 782

Query: 1530 LYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLH------LGSRLVASSQPQGAPA 1583
             + P+   +   V  E G   +L CR    P  ++T        LG RL A    +    
Sbjct: 783  GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRS--- 839

Query: 1584 EPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620
                     P++  +  E++ P DQ  Y+C A NV G
Sbjct: 840  -------RQPDSGVLFFESVAPEDQAPYVCEARNVFG 869



 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 173/795 (21%), Positives = 273/795 (34%), Gaps = 129/795 (16%)

Query: 910  QAVVLSCQVHTGVPEGTSYR----WYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAP 965
            Q +++SC VH+ +P     R       + +  QES +++      +  + G Y C A   
Sbjct: 442  QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAV-- 499

Query: 966  GSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVA 1025
             S   +  A   + V+  P  +     +   PG   +L CRV  + P  L  +   R++ 
Sbjct: 500  -SRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL- 557

Query: 1026 STLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF--- 1082
                    P  +     +A     L LEI G +  D G Y C ASN  G   AS      
Sbjct: 558  --------PASTGRVAQLA----DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR 605

Query: 1083 DAQAVNVQVWPGATVREGQLVNLTC---------LVWTTHPAQLTYTWYQDGQQRLDAH- 1132
            +A  V++         +G  V ++C         + W+     L     +D +  +DA  
Sbjct: 606  EAPQVSIHT-SSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL----QEDSRIHVDAQG 660

Query: 1133 SIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVL 1192
            ++ +  V   DA +Y C              +TL     P    +  ++    G+ A+++
Sbjct: 661  TLIIQGVAPEDAGNYSCQA--TNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 718

Query: 1193 CTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANT 1252
            C     PP ++     G  +  +   S    LR+     Q RD G Y+C A + LG A+ 
Sbjct: 719  CEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIP--AAQERDAGTYTCRAVNELGDASA 776

Query: 1253 SLELRLEGVRVI--LAPEAAVPEGAPITVTCADPAAHAPTLYTWYH-------------N 1297
             ++L +     +  L  +  V  G    + C       PT+ TW                
Sbjct: 777  EIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTV-TWRRGDGQPLGLRLGAGR 835

Query: 1298 GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLS--SFR 1355
            G   ++  +  L F          Y C+A++  G   +    +   +AP     S  + R
Sbjct: 836  GSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVR 895

Query: 1356 DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQD 1415
                + +++    +   P  E     DG+ L   S     A G+ H+  A     LQ   
Sbjct: 896  VLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRA-----LQEH- 949

Query: 1416 VPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLD--VPEGAALNLSCRLLGGPGP 1473
              AG   Y C A N  GS      L V+    +          EG   +L C   G P P
Sbjct: 950  --AG--RYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP 1005

Query: 1474 VGNSTFAWFWNDRRL-------HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVM 1526
                T  W      L       +     TL     +   AG Y C A    G ++     
Sbjct: 1006 ----TITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQE--- 1058

Query: 1527 LRVLYPPKTPTMMVFVE----PEGGLR---------GILDCRVDSEPLAS---------- 1563
            +R+       +  V+ E    P G LR         G  +C   S P  S          
Sbjct: 1059 MRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTA-SNPAGSASHRYVLGVQ 1117

Query: 1564 -----------LTLHLGSRLVASSQPQGAPAEPHIHVLASPNALR-------VDIEALRP 1605
                       L + +G  L  +   +G P EP +        L+       V   A+R 
Sbjct: 1118 VPPQVQPGPRVLKVLVGEALDLNCVAEGNP-EPQLSWSKDGVVLQGRGPQGSVHFAAIRT 1176

Query: 1606 SDQGEYICSASNVLG 1620
            SD G Y C ASN  G
Sbjct: 1177 SDAGRYRCEASNSAG 1191



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 118/490 (24%), Positives = 177/490 (36%), Gaps = 79/490 (16%)

Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT-LRLELRGPQPRDEGFYSCSAR 1244
            G+ A++ C V    P  L      R+L +ST        L LE+ G  P D G Y C A 
Sbjct: 531  GETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVAS 590

Query: 1245 SPLGQANTSLELRLEGVRVILAPEAAV-------PEGAPITVTCADPAAHAPTLYTWYHN 1297
            +  G    S+ L +       AP+ ++        +G  + V+C+      P + +W   
Sbjct: 591  NANGVTRASVWLLVRE-----APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI-SWSRE 644

Query: 1298 GRWLQEGPA------ASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVL 1351
             + LQE          +L         AG YSCQA +  GT       L     P  + +
Sbjct: 645  SQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGT-DQETVTLYYTDPPSVSAV 703

Query: 1352 SSFRDSRARSMAVIQCTVDSEPPAELALSHDG-KVLATSSGVHSLASGTGHVQVARNALR 1410
            ++         AV+ C     PP  +     G +++    G     S +G +++      
Sbjct: 704  NAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG-----SSSGKLRIPA---- 754

Query: 1411 LQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPE--GAALNLSCRLL 1468
               Q+  AG  TY C A N LG  S   +L V  A  + E   DV    G +  L+CR  
Sbjct: 755  --AQERDAG--TYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRAT 810

Query: 1469 GGPGPVGNSTFAWFWND-------------RRLHAEPVPTLAFTHVARAQAGMYHCLAEL 1515
            G P P    T  W   D              R        L F  VA      Y C A  
Sbjct: 811  GRPPP----TVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 866

Query: 1516 PTGAA-ASAPVMLRVLYPPK----TPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGS 1570
              G   A A +++    PP+     PT+ V               ++ +P++   + L  
Sbjct: 867  VFGKVQAEARLIVTGHAPPQIASSAPTVRV---------------LEGQPVSLPCIVLAG 911

Query: 1571 RLVASSQ--PQGAPAEPHI-HVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTY 1627
            R +        G P  P   H + +  +L +D  AL+    G Y C A+N  GS      
Sbjct: 912  RPLPERHWLKDGRPLPPGSRHSIRADGSLHLD-RALQ-EHAGRYSCVATNTAGSQHRDVE 969

Query: 1628 FGVRALHRLH 1637
              V+   R+H
Sbjct: 970  LVVQVPPRIH 979



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 82/328 (25%), Positives = 119/328 (36%), Gaps = 37/328 (11%)

Query: 100  LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159
            LL+K+L+ +D+G+Y    E +       V  T++ +   P   T+     L  G  +   
Sbjct: 4093 LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL---PVFTTLPGDRSLRLGDRLWLR 4149

Query: 160  CSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQL 219
            C+          R+ W   D  R VT      E  G   L+    A+S +D G  + C  
Sbjct: 4150 CAARG---SPTPRIGWTVND--RPVTEGVS--EQDGGSTLQ--RAAVSREDSGTYV-CWA 4199

Query: 220  SVANHRAQSEIHLQVKYAP----KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIK 275
                 R Q+   + VK AP    +    L+ P G +I       L C V      V  I 
Sbjct: 4200 ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSI------QLDCVVRGD--PVPDIH 4251

Query: 276  WLKDGVRL-------QTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEV 328
            W+KDG+ L       Q + G L + +    DAG Y C AEN +G      I +       
Sbjct: 4252 WIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVF 4311

Query: 329  QVSPAG-PILENQTVTLVCNTPNEAPSDLRYSWYKNHVL----LEDAHSHTLRLHLATRA 383
            QV P    +     V L C    E    + +      +     L      +L L      
Sbjct: 4312 QVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETG 4371

Query: 384  DTGFYFCEVQNVHGSERSGPVSVVVNHP 411
            D G Y C   N+ GS  +    VV   P
Sbjct: 4372 DAGTYDCVAHNLLGSATARAFLVVRGEP 4399


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score =  205 bits (522), Expect = 3e-52
 Identities = 356/1491 (23%), Positives = 543/1491 (36%), Gaps = 255/1491 (17%)

Query: 259  TLTCQVNSSYPAVSSIKWLKDGV------RLQTKTG--VLHLPQAAWSDAGVYTCQAENG 310
            T++ Q  +    V +I WL++G+      RLQ      VL +  A  +DA  Y C AEN 
Sbjct: 1580 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ 1639

Query: 311  VGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLR------YSWYKNH 364
             GS         +F   VQV P    L+ + VT + N+    P D+        +WYK+ 
Sbjct: 1640 AGSAEK------LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDS 1693

Query: 365  VLLEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSERS-GPVSVVV----NHPP 412
              L           +HTL+L  A  +D+G Y CE  N  G ++    +SV+V       P
Sbjct: 1694 QALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAP 1753

Query: 413  LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPN 472
              P     +  + G   +L C   + P  T+     G  L           R     G  
Sbjct: 1754 RGPQDAVLV--RVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQ-------RTQALRGGQ 1804

Query: 473  SLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE---GQAVTL 529
              RLEI++ + +D G Y C  +N  G A  T            +P  E V    G  + L
Sbjct: 1805 --RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVL 1862

Query: 530  SCRSGLSPTPDARFSWY-----LNGALLH--EGPGSSLLLPAASSTDAGSYHCRARDGHS 582
            +C   +S  P    +W      +  + +H     G  L L       AG+Y C A +  +
Sbjct: 1863 TC--DVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA 1920

Query: 583  ASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRV 642
             +      V+ VL  PR  +     +        G+   L C  D  PP  +  L     
Sbjct: 1921 EA--RKDFVVAVLVAPRIRSSGVAREHHVL---EGQEVRLDCEADGQPPPDVAWLKDGSP 1975

Query: 643  VATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSA 702
            +   +         GG S  +K  +A              + G Y C A N  G  +   
Sbjct: 1976 LGQDMGPHLRFYLDGG-SLVLKGLRA-------------SDAGAYTCVAHNPAGEDARLH 2021

Query: 703  TFNGQATVLAIAPSHTLQEGTEAN---------LTCNVSREAAGSPANFSWFRNGV---- 749
            T N     + + P  T+++G + +         L   V       P + SW ++G+    
Sbjct: 2022 TVN-----VLVPP--TIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL 2074

Query: 750  ---LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLD 806
                   G   T+ +  V   DA ++ C   + AG        L V  PP    +    D
Sbjct: 2075 SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGV-ADRNFTLQVQVPPVLEPVEFQND 2133

Query: 807  --MGQGHMALFICTVDSRPLALLA-LFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
              + +G +    C     PL L++ +  GE LL+ SL  Q PS              L++
Sbjct: 2134 VVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSL-EQGPS--------------LQL 2178

Query: 864  RELGLGDSGSYRCEATNVLGSSNTSLFFQV-RGAWVQVSPSP---ELQEGQAVVLSCQVH 919
              +G GDSG+Y C A +  G +       V     ++ S  P    L  G  + L C   
Sbjct: 2179 EAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 2238

Query: 920  TGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSA-----TTSLAA 974
             G P+  +  W++DGQ L    + +     + +  AG Y C A++P  A        + A
Sbjct: 2239 -GTPQ-PNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQA 2296

Query: 975  PISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034
            P ++     PR V     +   PG+L +L C V+++P  ++   H D +V          
Sbjct: 2297 PPNIVGPRGPRFV-----VGLAPGQL-VLECSVEAEPAPKI-TWHRDGIVL--------- 2340

Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG 1094
                   H         L++      D G Y C A N  G  S        A  V++   
Sbjct: 2341 ---QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSV-------AFRVEIHTV 2390

Query: 1095 ATVREGQ-----LVNLTCLVWTTH---PAQLTYTWYQDGQ---------QRLDAHSIPLP 1137
             T+R G       VN T L+       PA L  +W +D           + L   S+ + 
Sbjct: 2391 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLV-SWRKDRVPLDPRSPRFEILPEGSLRIQ 2449

Query: 1138 NVTVRDATSYRC------GVGPPGRAPRLSRPITLDVLYAPRNLRLT------YLLESHG 1185
             V  +DA  Y C      G    GR  R+  P    +  +P NL LT         E+ G
Sbjct: 2450 PVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPA--IAPSPSNLTLTAHTPALLPCEASG 2507

Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARS 1245
                LV+   D +         A RLL S+          L L  P P+D   + C   +
Sbjct: 2508 SPKPLVVWWKDGQKLDFRLQQGAYRLLPSNA---------LLLTAPGPQDSAQFECVVSN 2558

Query: 1246 PLGQANTSLELRLEGVRVILAPEAA-------VPEGAPITVTCADPAAHAPTLYTWYHNG 1298
             +G+A+     RL  V V + P  A       V   AP+ +TC      APT+ +W   G
Sbjct: 2559 EVGEAH-----RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTV-SWSKAG 2612

Query: 1299 RWL-------QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVL 1351
              L       +  P+ +L    A   HAG Y+C A+++ G  + +   L V  +P    L
Sbjct: 2613 AQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPL 2671

Query: 1352 SSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRL 1411
             S   + A    ++ C     P   +    +G  +AT  GV +     G +++A  +   
Sbjct: 2672 PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVAT--GVSTQVLPGGQLRIAHAS--- 2726

Query: 1412 QVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAE--PGLDVPEGAALNLSCRLLG 1469
                 P     Y+C A+N  GS     RL V+   V+    P L   EG+   L C+  G
Sbjct: 2727 -----PEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARG 2781

Query: 1470 GPGPVGNSTFAWFWN---------DRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAA 1520
             P P  N T    W+         + +   +P   L   ++    AG Y C AE   G A
Sbjct: 2782 SPEP--NIT----WDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRA 2835

Query: 1521 ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQG 1580
                V L +L  P   T+        G R  L C     P   +   +  R V       
Sbjct: 2836 RRR-VHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG---- 2890

Query: 1581 APAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
                    V        +   A+   D G Y+C A N +G     ++  V+
Sbjct: 2891 --------VSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 2933



 Score =  202 bits (515), Expect = 2e-51
 Identities = 373/1573 (23%), Positives = 580/1573 (36%), Gaps = 263/1573 (16%)

Query: 194  TGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNIL 253
            + VG L  L  A   Q+      C   V N  +  ++ L+V   P+       P+  +++
Sbjct: 932  SAVGRLLYLGQAQLAQEGTYTCECSNVVGN--SSQDLQLEVHVPPQIAGPREPPTQVSVV 989

Query: 254  PGELVTLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTC 305
               + TL C      P   ++ W +DG        ++LQ +   LH+ +A  +  G Y+C
Sbjct: 990  QDGVATLECNATGKPPP--TVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 1047

Query: 306  QAENGVGSLVSPPISLHIFMAEVQVSPAGPILE-----NQTVTLVCNTPNEAPSDLRYSW 360
             AEN  G        L + +    +    P+       +  +TL+C      P  +R  W
Sbjct: 1048 VAENLAGR-AERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIR--W 1104

Query: 361  YKNHVLL---EDAH----SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413
            ++    +   ED +       L++      D+G Y C   N  G  R    SV V  PP 
Sbjct: 1105 FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRN-FSVEVLVPPS 1163

Query: 414  --TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGP 471
                 L   ++   G    L C+V   P   L     G  LA   GD+ H         P
Sbjct: 1164 IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR--GDAHHI-------SP 1214

Query: 472  NSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAE-------VVEG 524
            + + L++     + +G Y C A N++G  T         A  ++  A +       V   
Sbjct: 1215 DGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVN 1274

Query: 525  QAVTLSCRSGLSPTPDARFSWYLNGALLHEG------PGS-SLLLPAASSTDAGSYHCRA 577
              ++L C +   P+P+   +W  +GA           PG+  L +  A   DAG Y C  
Sbjct: 1275 NPISLICEALAFPSPN--ITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVV 1332

Query: 578  RDGHSASGPSSPAVLTVLYPPR--QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635
             +    +  +    + VL PP   +      + +            L C   + PP  ++
Sbjct: 1333 TNELGEAVKNYH--VEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIR 1390

Query: 636  LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695
              +KD    T              S R++V     LL+++     + + G YLC A+N  
Sbjct: 1391 W-YKDGQPVTP-------------SSRLQVLGEGRLLQIQPTQ--VSDSGRYLCVATNVA 1434

Query: 696  GNASTS--------------ATFNGQATVLA--------IAPSHTLQEGTEANLTCNVSR 733
            G                     F+    +L+        +     + E   A L C+ + 
Sbjct: 1435 GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTN- 1493

Query: 734  EAAGSPANFSWFRNGVLWAQGPLETVTL------LPVARTD-AALYACRILTEAGAQLST 786
              A  P + +W+R     + G   +V        +P+ R + A  Y+C+   E G     
Sbjct: 1494 --AIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 1551

Query: 787  PVLLSVLYPP----DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGP 842
              LL VL PP    D  +L   + +         C     P+  ++        + S   
Sbjct: 1552 YELL-VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRL 1610

Query: 843  QVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSP 902
            QV   G+           L+V    + D+ SY C A N  GS+     F +R   VQV P
Sbjct: 1611 QVLEDGQV----------LQVSTAEVADAASYMCVAENQAGSAEK--LFTLR---VQVPP 1655

Query: 903  ---SPELQEGQAVV-----LSCQVHTGV-PEGTSYRWYRDGQPLQESTSA-------TLR 946
                 +L++  A++     L C VH    PE T   WY+D Q L             TL+
Sbjct: 1656 RIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT---WYKDSQALSLGEEVFLLPGTHTLQ 1712

Query: 947  FAAITLTQAGAYHCQA-QAPG--SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLL 1003
                 L+ +G Y C+A  A G       L+  +      APR      L+  G     +L
Sbjct: 1713 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDK--AVL 1770

Query: 1004 LCRVDSDP-PAQLRLLHGDRLV-ASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061
             C  D+ P P       G  LV A   Q + G +               RLEI  A + D
Sbjct: 1771 SCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ---------------RLEIQEAQVSD 1815

Query: 1062 EGVYICEASNTLGQASASADFDAQAVNVQVWPGA-TVRE--GQLVNLTCLVWTTHPAQLT 1118
            +G+Y C+ SN  G+A  +     Q       P   TV +  G  + LTC V +  PA  T
Sbjct: 1816 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAP-T 1873

Query: 1119 YTWYQDGQQRLDAHSIPLPNVTVR------------DATSYRCGVGPPGRAPRLSRPITL 1166
             TW +D   R+   S  +  V  R             A +Y C         R  +   +
Sbjct: 1874 VTWLKD---RMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR--KDFVV 1928

Query: 1167 DVLYAPRNLRLTYLLESH---GGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT 1223
             VL APR +R + +   H    GQ   + C  D +PP  +A    G  L       +   
Sbjct: 1929 AVLVAPR-IRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY 1987

Query: 1224 L---RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP---EAAVPEGAPI 1277
            L    L L+G +  D G Y+C A +P G+     + RL  V V++ P   + A   G  +
Sbjct: 1988 LDGGSLVLKGLRASDAGAYTCVAHNPAGE-----DARLHTVNVLVPPTIKQGADGSGTLV 2042

Query: 1278 T-----VTCADPAAHAPTLY-TWYHNG-------RWLQEGPAASLSFLVATRAHAGAYSC 1324
            +     VT   P   +P ++ +W  +G       R L  G   +L       A AG ++C
Sbjct: 2043 SRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC 2102

Query: 1325 QAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRA--RSMAVIQCTVDSEPPAELALSHD 1382
             A    G  + R   LQV   P    +    D      S+  + C     P   ++   D
Sbjct: 2103 VAASPAGV-ADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD 2161

Query: 1383 GKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQ 1441
            G+ L +     SL  G            LQ++ V AGD  TY C A +  G      +L 
Sbjct: 2162 GEPLLS----QSLEQGPS----------LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 2207

Query: 1442 VEGARVVAEPG----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLA 1497
            V     + + G    L +  GA + L C   G P P       W  + + L      + A
Sbjct: 2208 VMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQP----NITWHKDGQALTRLENNSRA 2263

Query: 1498 FTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYP-----PKTPTMMVFVEPEGGLRGIL 1552
               +    AG+Y CLAE P GA   +   +RV  P     P+ P  +V + P G L  +L
Sbjct: 2264 TRVLRVRDAGLYTCLAESPAGAIEKS-FRVRVQAPPNIVGPRGPRFVVGLAP-GQL--VL 2319

Query: 1553 DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612
            +C V++EP   +T H            G   +   H         + ++AL  +D G+Y 
Sbjct: 2320 ECSVEAEPAPKITWH----------RDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYS 2369

Query: 1613 CSASNVLGSASTS 1625
            C+A N  GS S +
Sbjct: 2370 CTARNAAGSTSVA 2382



 Score =  201 bits (511), Expect = 5e-51
 Identities = 379/1557 (24%), Positives = 563/1557 (36%), Gaps = 298/1557 (19%)

Query: 258  VTLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTCQAEN 309
            V+L C V++ +P    + W KD         V L   T  L L +A  SD+G+YTC+A N
Sbjct: 1673 VSLPCDVHA-HPN-PEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALN 1730

Query: 310  GVG---SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVL 366
              G    LV   + +     +    P   +L       V +   +A  +   +WYK+   
Sbjct: 1731 AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQP 1790

Query: 367  LEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPP-LTPVLT 418
            L  A           L +  A  +D G Y C+V NV G E     ++ V  PP      T
Sbjct: 1791 LVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKT 1849

Query: 419  AFLETQAGLVGILHCSVVSEPLATL--------VLSHGGHILASTSGDSDHSPRFSGTSG 470
              +   AG   +L C V   P  T+        V S   H + S  G             
Sbjct: 1850 ETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGG------------- 1896

Query: 471  PNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN---AARLLISPAAE---VVEG 524
                RL++  L+   +G Y C A N+   A    DF      A R+  S  A    V+EG
Sbjct: 1897 ----RLQLSRLQPAQAGTYTCVAENTQAEARK--DFVVAVLVAPRIRSSGVAREHHVLEG 1950

Query: 525  QAVTLSCRSGLSPTPDARFSWYLNGALLHE--GP-------GSSLLLPAASSTDAGSYHC 575
            Q V L C +   P PD   +W  +G+ L +  GP       G SL+L    ++DAG+Y C
Sbjct: 1951 QEVRLDCEADGQPPPDV--AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2008

Query: 576  RARDGHSASGPSSPA-VLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLL---CRVDSDPP 631
             A   H+ +G  +    + VL PP     T +   D +G    R G L+   C V   PP
Sbjct: 2009 VA---HNPAGEDARLHTVNVLVPP-----TIKQGADGSGTLVSRPGELVTMVCPVRGSPP 2060

Query: 632  ARLQLL------------------HKDRVVATSLPSGGGCSTCGGCSPR--------MKV 665
              +  L                  H  R+    L +  G  TC   SP         ++V
Sbjct: 2061 IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQL-ADAGIFTCVAASPAGVADRNFTLQV 2119

Query: 666  TKAPNLLRVEIHNPLLEEEGLYL---CEASN----------------------------- 693
               P L  VE  N ++   G  +   CEA                               
Sbjct: 2120 QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLE 2179

Query: 694  ALGNASTSATFN-------GQAT----VLAIAPSHTLQEG--TEANLTCNVSRE----AA 736
            A+G A  S T++       G+A     +  + P H    G  TE +LT     E    A 
Sbjct: 2180 AVG-AGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 2238

Query: 737  GSPA-NFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP 795
            G+P  N +W ++G    +    +     +   DA LY C   + AGA +     + V  P
Sbjct: 2239 GTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGA-IEKSFRVRVQAP 2297

Query: 796  PD-----RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRF 850
            P+      P+    L  GQ    +  C+V++ P   +       +L      Q P  GRF
Sbjct: 2298 PNIVGPRGPRFVVGLAPGQ---LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF 2354

Query: 851  QAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV----SPSPEL 906
                      L+++ L   DSG Y C A N  GS  TS+ F+V    V       P+  +
Sbjct: 2355 ----------LQLQALSTADSGDYSCTARNAAGS--TSVAFRVEIHTVPTIRSGPPAVNV 2402

Query: 907  QEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST-------SATLRFAAITLTQAGAYH 959
               Q  +L CQ   GVP      W +D  PL   +         +LR   +    AG Y 
Sbjct: 2403 SVNQTALLPCQAD-GVP-APLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL 2460

Query: 960  CQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDP-PAQLRL 1017
            C A  + GS        +    + AP    LT    T      LL C     P P  +  
Sbjct: 2461 CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTP----ALLPCEASGSPKPLVVWW 2516

Query: 1018 LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQAS 1077
              G +L     QG      S+  L  A  P            +D   + C  SN +G+A 
Sbjct: 2517 KDGQKLDFRLQQGAYRLLPSNALLLTAPGP------------QDSAQFECVVSNEVGEAH 2564

Query: 1078 ASADFDAQAVNVQVWPGATVREGQ----LVNLTCLVWTTHPAQL---TYTWYQDGQQRLD 1130
                     V V V P  T+ + Q    +  +  +V T H   +   T +W + G Q L 
Sbjct: 2565 R-----LYQVTVHVPP--TIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ-LG 2616

Query: 1131 AHSIPLPNVTVRDATSYRCGVGPPGRAPRLS-----------RPITLDVLYAPRNLRLTY 1179
            A         V  + +   G   P  A R +           + + L V  +P    L  
Sbjct: 2617 ARG---SGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPS 2673

Query: 1180 LLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFY 1239
            ++ +   +  L+ C     P   +     G  +A+  +  V    +L +    P D G Y
Sbjct: 2674 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNY 2733

Query: 1240 SCSARSPLGQA--NTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN 1297
             C A++  G A   T L +++  V     P+ +  EG+   + C    +  P + TW  +
Sbjct: 2734 LCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNI-TWDKD 2792

Query: 1298 GRWLQ--EG-----PAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAV 1350
            G+ +   EG     P+  L         AG Y+C A++A G R+ R   L +L  P    
Sbjct: 2793 GQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG-RARRRVHLTILVLPVFTT 2851

Query: 1351 LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR 1410
            L   R  R      ++C     P   +  + + + +          S      V+R    
Sbjct: 2852 LPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSRE--- 2908

Query: 1411 LQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV---AEPGLDVPEGAALNLSCRL 1467
                       TYVC A+N +G    +  + V+ A V+   A   L  P G ++ L C +
Sbjct: 2909 --------DSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV 2960

Query: 1468 LGGPGPVGNSTFAWFWNDRRL------HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAA 1521
             G P P       W  +   L      H     +L      R  AG Y CLAE   G A 
Sbjct: 2961 RGDPVP----DIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAK 3016

Query: 1522 SAPVMLRVLYPPKTPTMMVF-VEPE-----GGLRGILDCRVDSEPLASLT-LHLGSRLVA 1574
               +++    P       VF VEP+      G    L C+   EP  ++  L  G  L A
Sbjct: 3017 KVVILVLQSAP-------VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRA 3069

Query: 1575 SSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
            S + +  P               + +E +   D G Y C A N+LGSA+   +  VR
Sbjct: 3070 SRRLRTLPDGS------------LWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3114



 Score =  180 bits (457), Expect = 9e-45
 Identities = 398/1681 (23%), Positives = 604/1681 (35%), Gaps = 297/1681 (17%)

Query: 100  LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRV---PTIASPVELLEGTEV 156
            L ++  Q  D+GSY  R   S V   ++++  L  V   PR+   P++  PV  L  T V
Sbjct: 659  LRIEQAQLSDAGSY--RCVASNVAGSTELRYGL-RVNVPPRITLPPSLPGPV--LVNTPV 713

Query: 157  DFNCSTPYVCLQEQVRLQW--QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRI 214
               C+           L W   G   + + T   Q F     G + TL  A +  D GR 
Sbjct: 714  RLTCNATGA---PSPTLMWLKDGNPVSPAGTPGLQVFPG---GRVLTLASARA-SDSGRY 766

Query: 215  LRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSI 274
                +S      Q ++ LQV   P    IL      +++  E V L CQ ++  P V S 
Sbjct: 767  SCVAVSAVGEDRQ-DVVLQVHMPPS---ILGEELNVSVVANESVALECQSHAMPPPVLS- 821

Query: 275  KWLKDGVRLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA 326
             W KDG  L+ + GV        L + +A   DAG YTC+A N  G       S   +  
Sbjct: 822  -WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGH------SEKHYNL 874

Query: 327  EVQVSPAGPILENQTVTLVCNTPNEAPSDLR------YSWYKNHVLLE---------DAH 371
             V V+P  P+ E+ T+T+    P     + R       SW K+   L           A 
Sbjct: 875  NVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAV 934

Query: 372  SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTP----VLTAFLETQAGL 427
               L L  A  A  G Y CE  NV G+  S  + + V+ PP         T     Q G 
Sbjct: 935  GRLLYLGQAQLAQEGTYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDG- 992

Query: 428  VGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
            V  L C+   +P  T+     G  + +  G    +   S         L +   +   +G
Sbjct: 993  VATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQS---------LHVERAQAAHTG 1043

Query: 488  EYKCSATNSLGNATSTLDFHANAARLLIS---PAAEVVEG--QAVTLSCRSGLSPTPDAR 542
             Y C A N  G A    +        LI    P   +       +TL C +   P P  R
Sbjct: 1044 RYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIR 1103

Query: 543  FSWYLNGALLHEGPGSSLL-------LPAASSTDAGSYHCRARDGHSASGPSSPAVLTVL 595
              W+     +  G  + LL       +      D+G Y C A   + A        + VL
Sbjct: 1104 --WFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA--SNEAGEARRNFSVEVL 1159

Query: 596  YPPRQPTFTTRLDLDAA-GAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCS 654
             PP         DL+       G+   L+C V   P  +L      R +A          
Sbjct: 1160 VPPS----IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR--------- 1206

Query: 655  TCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIA 714
               G +  +    +P+ + +++    L   G Y C A+NA+G      T + Q +VL +A
Sbjct: 1207 ---GDAHHI----SPDGVLLQVLQANLSSAGHYSCIAANAVG----EKTKHFQLSVL-LA 1254

Query: 715  PS--HTLQEGTEANLTCNVSR------EAAGSPA-NFSWFRNGVLWAQGPLETVTLLP-- 763
            P+     ++  +  +T  V+       EA   P+ N +W ++G  +       + LLP  
Sbjct: 1255 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEAS--RNIQLLPGT 1312

Query: 764  -------VARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFI 816
                     + DA  Y C +  E G  +     + VL PP   K   L ++G   +   +
Sbjct: 1313 HGLQILNAQKEDAGQYTCVVTNELGEAVKN-YHVEVLIPPSISKDDPLAEVGVKEVKTKV 1371

Query: 817  -------CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869
                   C   + P   +  +     +  S   QV   GR           L+++   + 
Sbjct: 1372 NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL----------LQIQPTQVS 1421

Query: 870  DSGSYRCEATNVLGSSNTSL--------FFQVRG--------------AWVQVSPSPELQ 907
            DSG Y C ATNV G  +            FQ  G              A   V+   E+ 
Sbjct: 1422 DSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIV 1481

Query: 908  EGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT-------LRFAAITLTQAGAYHC 960
            E     L C  +   P   +  WYR+ QPL      +       L+   +    AG Y C
Sbjct: 1482 ENNPAYLYCDTNAIPPPDLT--WYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSC 1539

Query: 961  QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020
            +A       ++      LH  Y    +T   ++      +  +     S    Q   L  
Sbjct: 1540 KA-------SNEVGEDWLH--YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN 1590

Query: 1021 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080
                 S LQ  G P   SPRL V        L++  A + D   Y+C A N  G A    
Sbjct: 1591 PVPTISWLQN-GLPFSPSPRLQVLEDGQV--LQVSTAEVADAASYMCVAENQAGSAE--- 1644

Query: 1081 DFDAQAVNVQVWP--------GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL--- 1129
                  + VQV P          T      V+L C V   HP     TWY+D Q      
Sbjct: 1645 --KLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDV-HAHP-NPEVTWYKDSQALSLGE 1700

Query: 1130 ------DAHSIPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVL------YAPRNLR 1176
                    H++ L    + D+  Y C  +   GR  +L   + L VL       APR  +
Sbjct: 1701 EVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL---VQLSVLVPPAFRQAPRGPQ 1757

Query: 1177 LTYLLESHGGQLALVLCTVDSRPPAQLALSHAGR-LLASSTAASVPNTLRLELRGPQPRD 1235
               L+    G  A++ C  D+ P   +     G+ L+ +    ++    RLE++  Q  D
Sbjct: 1758 DAVLVRV--GDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSD 1815

Query: 1236 EGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE---GAPITVTCADPAAHAPTLY 1292
            +G YSC   +  G+A  +  L ++       P+        G+P+ +TC      APT+ 
Sbjct: 1816 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV- 1874

Query: 1293 TWYHNGRWLQEGP-------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYA 1345
            TW  +   ++             L       A AG Y+C A++ Q   + +   + VL A
Sbjct: 1875 TWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQ-AEARKDFVVAVLVA 1933

Query: 1346 PQDAVLSSFRDSRARSMAVIQ--CTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403
            P+       R+        ++  C  D +PP ++A   DG  L    G H      G   
Sbjct: 1934 PRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSL 1993

Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV-------EGA----RVVAEPG 1452
            V +    L+  D  A    Y C A N  G  + +  + V       +GA     +V+ P 
Sbjct: 1994 VLKG---LRASDAGA----YTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRP- 2045

Query: 1453 LDVPEGAALNLSCRLLGGPGPVGNSTFAWF-------WNDRRLHAEPVPTLAFTHVARAQ 1505
                 G  + + C + G P P+  S   W         + R L      TL  + V  A 
Sbjct: 2046 -----GELVTMVCPVRGSP-PIHVS---WLKDGLPLPLSQRTLLHGSGHTLRISKVQLAD 2096

Query: 1506 AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI---LDCRVDSEPLA 1562
            AG++ C+A  P G  A     L+V  PP     + F      +RG    L C     PL 
Sbjct: 2097 AGIFTCVAASPAG-VADRNFTLQVQVPPVLEP-VEFQNDVVVVRGSLVELPCEARGVPLP 2154

Query: 1563 SLT-LHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621
             ++ +  G  L++ S  QG                 + +EA+   D G Y C A +  G 
Sbjct: 2155 LVSWMKDGEPLLSQSLEQGP---------------SLQLEAVGAGDSGTYSCVAVSEAGE 2199

Query: 1622 A 1622
            A
Sbjct: 2200 A 2200



 Score =  176 bits (446), Expect = 2e-43
 Identities = 381/1579 (24%), Positives = 580/1579 (36%), Gaps = 296/1579 (18%)

Query: 200  ETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVT 259
            ++LH+  +   H     C       RA+ +  L V   P+ +  L   +         +T
Sbjct: 1030 QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLT 1089

Query: 260  LTCQVNSSYPAVSSIKWLK--------DGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGV 311
            L C+     P   +I+W +        +   L     +L + Q    D+G+Y+C A N  
Sbjct: 1090 LLCEAMGIPPP--AIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEA 1147

Query: 312  GSLVSPPISLHIFMAEVQVSPAGP---------ILENQTVTLVCNTPNEAPSDLRYSWYK 362
            G       +   F  EV V P+           +L+ QT  L+CN        L  +W+K
Sbjct: 1148 GE------ARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFK 1199

Query: 363  NHVLLEDAHSH-------TLRLHLATRADTGFYFCEVQNVHGSE-RSGPVSVVVNHPPLT 414
            +   L    +H        L++  A  +  G Y C   N  G + +   +SV+     L 
Sbjct: 1200 DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL-----LA 1254

Query: 415  PVLTAFLETQAG---LVGI-----LHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466
            P +    E  A     V +     L C  ++ P   +     G    +    S +     
Sbjct: 1255 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEA----SRNIQLLP 1310

Query: 467  GTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA-------A 519
            GT G     L+I + ++ D+G+Y C  TN LG A    ++H     +LI P+       A
Sbjct: 1311 GTHG-----LQILNAQKEDAGQYTCVVTNELGEAVK--NYH---VEVLIPPSISKDDPLA 1360

Query: 520  EV-------VEGQAVTLSCRSGLSPTPDARFSWYLNG-------ALLHEGPGSSLLLPAA 565
            EV            +TL C S   P P  R  WY +G        L   G G  L +   
Sbjct: 1361 EVGVKEVKTKVNSTLTLECESWAVPPPTIR--WYKDGQPVTPSSRLQVLGEGRLLQIQPT 1418

Query: 566  SSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP---RQPTFTTRLDL-----DAAGAGAG 617
              +D+G Y C A +           ++ V  PP   +   F+   ++     +A G    
Sbjct: 1419 QVSDSGRYLCVATNVAGEDDQDFNVLIQV--PPMFQKVGDFSAAFEILSREEEARGGVTE 1476

Query: 618  RRGL-------LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPN 670
             R +       L C  ++ PP  L    +D+     L +G   S   G     +V + P 
Sbjct: 1477 YREIVENNPAYLYCDTNAIPPPDLTWYREDQ----PLSAGDEVSVLQG----GRVLQIP- 1527

Query: 671  LLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCN 730
            L+R        E  G Y C+ASN +G              + +  +  L E    N +  
Sbjct: 1528 LVRA-------ENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASST 1580

Query: 731  VSRE--AAGSPA-NFSWFRNGVLWAQGP----LETVTLLPVAR---TDAALYACRILTEA 780
            VS +  A G+P    SW +NG+ ++  P    LE   +L V+     DAA Y C    +A
Sbjct: 1581 VSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQA 1640

Query: 781  GAQLSTPVLLSVLYPP-----DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHL 835
            G+       L V  PP     D  +++A+L+          C V + P   +  +     
Sbjct: 1641 GS-AEKLFTLRVQVPPRIAGLDLEQVTAILNSS----VSLPCDVHAHPNPEVTWYKDSQ- 1694

Query: 836  LATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN--TSLFFQV 893
             A SLG +V             +  L++    L DSG Y CEA N  G       L   V
Sbjct: 1695 -ALSLGEEV--------FLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV 1745

Query: 894  RGAWVQVSPSPE----LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP--LQESTSA---- 943
              A+ Q    P+    ++ G   VLSC+    +PE T   WY+DGQP  L + T A    
Sbjct: 1746 PPAFRQAPRGPQDAVLVRVGDKAVLSCET-DALPEPT-VTWYKDGQPLVLAQRTQALRGG 1803

Query: 944  -TLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYA-PRHVTLTTLMDTGPGRL 1000
              L      ++  G Y C+ +   G A  +    + +  ++  P+  T++ +     G  
Sbjct: 1804 QRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQV----AGSP 1859

Query: 1001 GLLLCRVDSDPPAQLRLLHGDRL--VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAM 1058
             +L C V   P   +  L  DR+   +S + GV    G              RL++    
Sbjct: 1860 LVLTCDVSGVPAPTVTWLK-DRMPVESSAVHGVVSRGG--------------RLQLSRLQ 1904

Query: 1059 LEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGAT---------VREGQLVNLTCLV 1109
                G Y C A NT  QA A  DF    V V V P            V EGQ V L C  
Sbjct: 1905 PAQAGTYTCVAENT--QAEARKDF---VVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEA 1959

Query: 1110 WTTHPAQLTYTWYQDGQQ-----------RLDAHSIPLPNVTVRDATSYRC-GVGPPGRA 1157
                P  +   W +DG              LD  S+ L  +   DA +Y C    P G  
Sbjct: 1960 DGQPPPDV--AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 2017

Query: 1158 PRLSRPITLDVLYAP---RNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLAS 1214
             RL    T++VL  P   +    +  L S  G+L  ++C V   PP  ++    G  L  
Sbjct: 2018 ARLH---TVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL 2074

Query: 1215 STAASVPNT-LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP-----E 1268
            S    +  +   L +   Q  D G ++C A SP G A+ +  L+++ V  +L P     +
Sbjct: 2075 SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ-VPPVLEPVEFQND 2133

Query: 1269 AAVPEGAPITVTCADPAAHAPTLYTWYHNG-----RWLQEGPAASLSFLVATRAHAGAYS 1323
              V  G+ + + C       P L +W  +G     + L++GP+  L  + A    +G YS
Sbjct: 2134 VVVVRGSLVELPCEARGVPLP-LVSWMKDGEPLLSQSLEQGPSLQLEAVGA--GDSGTYS 2190

Query: 1324 CQAQDAQGTRSSRPAALQVLYAP--QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSH 1381
            C A    G  + R   L V+  P  +D+   +       +   + C     P   +    
Sbjct: 2191 CVAVSEAG-EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK 2249

Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQ 1441
            DG+ L            T     +R    L+V+D       Y C A++  G+I    R+ 
Sbjct: 2250 DGQAL------------TRLENNSRATRVLRVRDA----GLYTCLAESPAGAIEKSFRV- 2292

Query: 1442 VEGARVVAEPGLDVPEG---------AALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP 1492
                RV A P +  P G           L L C +   P P       W   D  +  E 
Sbjct: 2293 ----RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAP----KITWH-RDGIVLQED 2343

Query: 1493 VPT--------LAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLY--PPKTPTMMVFV 1542
              T        L    ++ A +G Y C A     AA S  V  RV     P   +    V
Sbjct: 2344 AHTQFPERGRFLQLQALSTADSGDYSCTAR---NAAGSTSVAFRVEIHTVPTIRSGPPAV 2400

Query: 1543 EPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEA 1602
                    +L C+ D  P A L      R+         P  P   +L    +LR  I+ 
Sbjct: 2401 NVSVNQTALLPCQADGVP-APLVSWRKDRVPLD------PRSPRFEILPE-GSLR--IQP 2450

Query: 1603 LRPSDQGEYICSASNVLGS 1621
            +   D G Y+C ASN  GS
Sbjct: 2451 VLAQDAGHYLCLASNSAGS 2469



 Score =  162 bits (409), Expect = 3e-39
 Identities = 357/1546 (23%), Positives = 551/1546 (35%), Gaps = 319/1546 (20%)

Query: 253  LPGELVTLTCQVNSSYPAVSSIKWLKD-----------------------GVRLQTKTGV 289
            + G+ +TL C  N  +P V  I WLKD                       G RL  +   
Sbjct: 31   MAGQSLTLECDANG-FP-VPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQS 88

Query: 290  LHLPQAAWSDAGVYTCQAENGVGS--------LVSPPISLHIFMAEVQVSPAGPILENQT 341
            LH P+    D+G+Y+C+AEN  G+        +++PP  L    A+  +  AG  +E Q 
Sbjct: 89   LHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQC 148

Query: 342  VTLVCNTPNEAPSDLRYSWYKN---------HVLLEDAHSHTLRLHLATRADTGFYFCEV 392
             T    TP       +  W K+         H+ +++     LR+  +   D G Y C  
Sbjct: 149  WTSGVPTP-------QVEWTKDRQPVLPGGPHLQVQE-DGQVLRITGSHVGDEGRYQCVA 200

Query: 393  QNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILH-------CSVVSEPLATLVL 445
             +  G +++    + V+ PP     T +   + G V ++        C     P   +  
Sbjct: 201  FSPAG-QQARDFQLRVHAPP-----TIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW 254

Query: 446  SHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD 505
               G +L +       S +   T G    +L++   + +D+G Y C A+N++G A     
Sbjct: 255  FKDGALLPT-------STKVVYTRG--GRQLQLGRAQSSDAGVYTCKASNAVGAAEK--- 302

Query: 506  FHANAARLLISPAAE----------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEG 555
              A    + + P  E           V G+ V L C +   P+P    SW+  G  + E 
Sbjct: 303  --ATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP--TLSWHHEGLPVAES 358

Query: 556  -------PGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVL----TVLYPPRQPTFT 604
                    GS L L +     +G Y C       AS P+  AVL     V  PP+     
Sbjct: 359  NESRLETDGSVLRLESPGEASSGLYSC------VASSPAGEAVLQYSVEVQVPPQL---- 408

Query: 605  TRLDLDAAGAG-----AGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGC 659
                L A G G      G+   L C+    P   +Q L   R  A  L            
Sbjct: 409  ----LVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR-PAEELAG---------- 453

Query: 660  SPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG--NASTSATFNGQ-ATVLAIAPS 716
                 V  A     + I +  L+  GL+ C+A+N  G   A    + +G+ A  +   P 
Sbjct: 454  -----VQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPI 508

Query: 717  HTLQEGTEANLTCNVSREA---------AGSPANFSWFRNGVLWAQ--GPLETVTLLP-- 763
                 G E + +   + +             P    W   G LW +  G     +L P  
Sbjct: 509  GQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPL 568

Query: 764  ----VARTDAALYACRILTEAGAQLSTPVLLSVLYPPD---RPKLSALLDMGQGHMALFI 816
                V   D  +Y C     AG +    V L VL PP+    P   A+L+          
Sbjct: 569  QIEKVDLRDEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENAS---VTLE 624

Query: 817  CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRC 876
            C     P   ++ F G   +++ +G  V   GR           L + +  L D+GSYRC
Sbjct: 625  CLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----------LRIEQAQLSDAGSYRC 674

Query: 877  EATNVLGSSNTSLFFQVRGAWVQVSPS---PELQEGQAVV-----LSCQVHTGVPEGTSY 928
             A+NV GS  T L + +R   V V P    P    G  +V     L+C   TG P  T  
Sbjct: 675  VASNVAGS--TELRYGLR---VNVPPRITLPPSLPGPVLVNTPVRLTCNA-TGAPSPT-L 727

Query: 929  RWYRDGQPLQESTS---------ATLRFAAITLTQAGAYHCQA-QAPGSATTSLAAPISL 978
             W +DG P+  + +           L  A+   + +G Y C A  A G     +   + +
Sbjct: 728  MWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHM 787

Query: 979  HVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSS 1038
              S     + ++ + +        L C+  + PP  L      R +              
Sbjct: 788  PPSILGEELNVSVVANESVA----LECQSHAMPPPVLSWWKDGRPL-------------E 830

Query: 1039 PRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVR 1098
            PR  V ++ +   L++  A + D G Y CEA N  G +    +     +NV V P   +R
Sbjct: 831  PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYN-----LNVWVAPVFPLR 885

Query: 1099 EGQLVNLTCLVWTTHPAQLT----------YTWYQDGQ---------QRLDA--HSIPLP 1137
            E      T  V   HP +L+           +W +DGQ         Q + A    + L 
Sbjct: 886  ESH----TLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLG 941

Query: 1138 NVTVRDATSYRCGVGPPGRAPRLSRPITLDV-----LYAPRNLRLTYLLESHGGQLALVL 1192
               +    +Y C           S+ + L+V     +  PR       +   G  +A + 
Sbjct: 942  QAQLAQEGTYTCECS--NVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDG--VATLE 997

Query: 1193 CTVDSRPPAQLALSHAGRLLASSTAASVPNT-LRLELRGPQPRDEGFYSCSARSPLGQAN 1251
            C    +PP  +     G+ + +     + N    L +   Q    G YSC A +  G+A 
Sbjct: 998  CNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAE 1057

Query: 1252 TSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNG------RWLQ-EG 1304
               EL       +L P   + +  P+T   A  A H+P        G      RW + E 
Sbjct: 1058 RKFELS------VLVPPELIGDLDPLTNITA--ALHSPLTLLCEAMGIPPPAIRWFRGEE 1109

Query: 1305 PAA------------SLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP--QDAV 1350
            P +             L         +G YSC A +  G  + R  +++VL  P  ++  
Sbjct: 1110 PVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAG-EARRNFSVEVLVPPSIENED 1168

Query: 1351 LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR 1410
            L           A + C V   P  +L    DG+ LA     H    G   +QV      
Sbjct: 1169 LEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGV-LLQV------ 1221

Query: 1411 LQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV-------EGARVVAEPGLDVPEGAALNL 1463
            LQ     AG   Y C A N +G  +   +L V        GA   A+  + V     ++L
Sbjct: 1222 LQANLSSAGH--YSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISL 1279

Query: 1464 SCRLLGGPGPVGNSTF----AWFWNDRRLHAEP-VPTLAFTHVARAQAGMYHCLAELPTG 1518
             C  L  P P  N T+    A F   R +   P    L   +  +  AG Y C+     G
Sbjct: 1280 ICEALAFPSP--NITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 1337

Query: 1519 AAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASS-- 1576
             A      + VL PP        +  +  L  +    V ++  ++LTL   S  V     
Sbjct: 1338 EAVK-NYHVEVLIPPS-------ISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTI 1389

Query: 1577 --QPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620
                 G P  P   +        + I+  + SD G Y+C A+NV G
Sbjct: 1390 RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAG 1435



 Score =  155 bits (391), Expect = 4e-37
 Identities = 382/1680 (22%), Positives = 580/1680 (34%), Gaps = 292/1680 (17%)

Query: 105  LQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELL--EGTEVDFNCST 162
            +Q  DSG Y+ R E        D    ++T    P V    +  E+L   G +V+  C T
Sbjct: 94   IQEGDSGLYSCRAENQAGTAQRDFHLLVLT---PPSVLGAGAAQEVLGLAGADVELQCWT 150

Query: 163  PYVCLQEQVRLQW-QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSV 221
              V   +   ++W + + P      + Q  E   V  +   H+     D GR      S 
Sbjct: 151  SGVPTPQ---VEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG----DEGRYQCVAFSP 203

Query: 222  ANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGV 281
            A  +A+ +  L+V +AP  +          ++   LV L C+         +I W KDG 
Sbjct: 204  AGQQAR-DFQLRV-HAPPTIWGSNETGEVAVMEDHLVQLLCEARGV--PTPNITWFKDGA 259

Query: 282  RLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPA 333
             L T T V        L L +A  SDAGVYTC+A N VG+       L +++        
Sbjct: 260  LLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAG 318

Query: 334  G-----PILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH-------SHTLRLHLAT 381
            G       +  + V L C         L  SW+   + + +++          LRL    
Sbjct: 319  GRPYVVKAVAGRPVALECVARGHPSPTL--SWHHEGLPVAESNESRLETDGSVLRLESPG 376

Query: 382  RADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF--LETQAGLVGILHCSVVSEP 439
             A +G Y C   +  G E     SV V  PP   V      + T  G    L C     P
Sbjct: 377  EASSGLYSCVASSPAG-EAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP 435

Query: 440  LATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGN 499
            + T+     G      +G    S    GT+      L I  +E   SG + C ATN  G 
Sbjct: 436  VPTIQWLQNGRPAEELAGVQVAS---QGTT------LHIDHVELDHSGLFACQATNEAGT 486

Query: 500  ATSTLDFHAN---AARLLISPAAEVVEG----QAVTLSCRS------GLSPTPDARFSWY 546
            A + ++   +   A  +L  P  +   G     +   +C        G  P P     W 
Sbjct: 487  AGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWC 546

Query: 547  LNGALLHEGPG--------SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
              G+L  E  G          L +      D G Y C A   + A        L VL PP
Sbjct: 547  SPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT--NLAGESKREVALKVLVPP 604

Query: 599  R-QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCG 657
              +P    +  L+ A         L C     PP  +      + V              
Sbjct: 605  NIEPGPVNKAVLENASV------TLECLASGVPPPDVSWFKGHQPV-------------- 644

Query: 658  GCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATV---LAIA 714
              S  M VT + +   + I    L + G Y C ASN  G  ST   +  +  V   + + 
Sbjct: 645  --SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG--STELRYGLRVNVPPRITLP 700

Query: 715  PS--HTLQEGTEANLTCNVSREAAGSPA-NFSWFRNG--VLWAQGP-------LETVTLL 762
            PS    +   T   LTCN    A G+P+    W ++G  V  A  P          +TL 
Sbjct: 701  PSLPGPVLVNTPVRLTCN----ATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLA 756

Query: 763  PVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSR 822
                +D+  Y+C  ++  G      V+L V  PP        + +         C   + 
Sbjct: 757  SARASDSGRYSCVAVSAVGED-RQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAM 815

Query: 823  PLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVL 882
            P  +L+ +              P   R      A+   L+V    + D+G Y CEA N  
Sbjct: 816  PPPVLSWWKDGR----------PLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 865

Query: 883  GSSNTSLFFQVRGAWV------QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP 936
            G S       V   WV      + S +  ++EG    LSC+   GVP      W +DGQP
Sbjct: 866  GHSEKHYNLNV---WVAPVFPLRESHTLTVREGHPTRLSCECR-GVP-FPKISWRKDGQP 920

Query: 937  LQESTSATLRFAAI---------TLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYA-PR 985
            L    +     +A+          L Q G Y C+ +   G+++  L   + +    A PR
Sbjct: 921  LPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPR 980

Query: 986  H-VTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVA 1044
               T  +++  G   +  L C     PP  +           T +  G P G+   L + 
Sbjct: 981  EPPTQVSVVQDG---VATLECNATGKPPPTV-----------TWERDGQPVGAELGLQLQ 1026

Query: 1045 VAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVN 1104
                +L +E   A     G Y C A N  G+A    +     ++V V P        L N
Sbjct: 1027 NQGQSLHVE--RAQAAHTGRYSCVAENLAGRAERKFE-----LSVLVPPELIGDLDPLTN 1079

Query: 1105 LTCLVWTTHPAQL----------TYTWY---------QDGQQRLDAHSIPLPNVTVRDAT 1145
            +T  + +  P  L             W+         +D         + +     +D+ 
Sbjct: 1080 ITAALHS--PLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSG 1137

Query: 1146 SYRCGVGPPGRAPRLSRPITLDVLYAP--RNLRLTYLLESHGGQLALVLCTVDSRPPAQL 1203
             Y C       A    R  +++VL  P   N  L  +++   GQ A ++C V   P  +L
Sbjct: 1138 LYSCLAS--NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL 1195

Query: 1204 ALSHAGRLLASSTAASV-PNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVR 1262
                 GR LA   A  + P+ + L++        G YSC A + +G+     +L      
Sbjct: 1196 TWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQL-----S 1250

Query: 1263 VILAP------------EAAVPEGAPITVTCADPAAHAPTLYTWYHNG------RWLQEG 1304
            V+LAP            E  V    PI++ C   A  +P + TW  +G      R +Q  
Sbjct: 1251 VLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNI-TWMKDGAPFEASRNIQLL 1309

Query: 1305 PAA-SLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP---QDAVLSSFR----D 1356
            P    L  L A +  AG Y+C   +  G  + +   ++VL  P   +D  L+        
Sbjct: 1310 PGTHGLQILNAQKEDAGQYTCVVTNELG-EAVKNYHVEVLIPPSISKDDPLAEVGVKEVK 1368

Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416
            ++  S   ++C   + PP  +    DG+ +  SS +  L  G            LQ+Q  
Sbjct: 1369 TKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR----------LLQIQPT 1418

Query: 1417 PAGDD-TYVCTAQNLLGS--------------ISTIGRLQV--------EGARVVAEPGL 1453
               D   Y+C A N+ G                  +G            E AR       
Sbjct: 1419 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 1478

Query: 1454 DVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA-------EPVPTLAFTHVARAQA 1506
            ++ E     L C     P P       W+  D+ L A       +    L    V    A
Sbjct: 1479 EIVENNPAYLYCDTNAIPPP----DLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENA 1534

Query: 1507 GMYHCLAELPTGAAASAPVMLRVLYPP----KTPTMMVFVEPEGGLRGILDCRVDSEPLA 1562
            G Y C A    G       +L VL PP     T  ++  V         L C     P+ 
Sbjct: 1535 GRYSCKASNEVGEDWLHYELL-VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVP 1593

Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
            ++          S    G P  P   +    +   + +     +D   Y+C A N  GSA
Sbjct: 1594 TI----------SWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA 1643



 Score =  149 bits (375), Expect = 3e-35
 Identities = 309/1299 (23%), Positives = 445/1299 (34%), Gaps = 234/1299 (18%)

Query: 251  NILPGELVTLTCQVNSSYPAVSSIKWLKDG----------VRLQTKTGVLHLPQAAWSDA 300
            ++L G+ V L C+ +   P    + WLKDG          +R     G L L     SDA
Sbjct: 1946 HVLEGQEVRLDCEADGQPPP--DVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA 2003

Query: 301  GVYTCQAENGVGS---------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNE 351
            G YTC A N  G          LV P I      +   VS  G +     VT+VC     
Sbjct: 2004 GAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGEL-----VTMVCPVRGS 2058

Query: 352  APSDLRYSWYKNHVLLE-------DAHSHTLRLHLATRADTGFYFCEVQNVHG-SERSGP 403
             P  +  SW K+ + L            HTLR+     AD G + C   +  G ++R+  
Sbjct: 2059 PP--IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFT 2116

Query: 404  VSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP 463
            + V V  P L PV     E Q  +V      VV   L  L     G  L   S   D  P
Sbjct: 2117 LQVQVP-PVLEPV-----EFQNDVV------VVRGSLVELPCEARGVPLPLVSWMKDGEP 2164

Query: 464  RFSGT--SGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEV 521
              S +   GP+   L++  +   DSG Y C A +  G A             ++ P    
Sbjct: 2165 LLSQSLEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQL------TVMEPPHIE 2215

Query: 522  VEGQAVTLSCRSGL--------SPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSY 573
              GQ   LS   G           TP    +W+ +G  L     +S         DAG Y
Sbjct: 2216 DSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLY 2275

Query: 574  HCRARDGHSASGPSSPAVLTV---LYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDP 630
             C A     A   S    +     +  PR P F   L        A  + +L C V+++P
Sbjct: 2276 TCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGL--------APGQLVLECSVEAEP 2327

Query: 631  PARLQLLHKDRVVA-----TSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685
              ++   H+D +V      T  P  G                      +++      + G
Sbjct: 2328 APKITW-HRDGIVLQEDAHTQFPERGRF--------------------LQLQALSTADSG 2366

Query: 686  LYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANF-SW 744
             Y C A NA G  STS  F  +   +    S         N T  +  +A G PA   SW
Sbjct: 2367 DYSCTARNAAG--STSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSW 2424

Query: 745  FRNGV-------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPD 797
             ++ V        +   P  ++ + PV   DA  Y C     AG+      L  VL PP 
Sbjct: 2425 RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDL-RVLEPPA 2483

Query: 798  RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEAN 857
                 + L +     AL  C     P  L+  +     L   L       G ++    +N
Sbjct: 2484 IAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL-----QQGAYRL-LPSN 2537

Query: 858  SLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQA------ 911
            +L L     G  DS  + C  +N +G ++       R   V V   P + + Q       
Sbjct: 2538 ALLLTAP--GPQDSAQFECVVSNEVGEAH-------RLYQVTVHVPPTIADDQTDFTVTM 2588

Query: 912  ---VVLSCQVHTGVPEGTSYRWYRDGQPL-------QESTSATLRFAAITLTQAGAYHCQ 961
               VVL+C   TG+P  T   W + G  L       + S S  L         AG Y C 
Sbjct: 2589 MAPVVLTCH-STGIPAPT-VSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCS 2646

Query: 962  AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGD 1021
            A+            + L V  +P    L +++        LL C     P   +      
Sbjct: 2647 ARNSAGVAHK---HVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG 2703

Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081
              VA+ +     P G              +L I  A  ED G Y+C A N+ G A     
Sbjct: 2704 LNVATGVSTQVLPGG--------------QLRIAHASPEDAGNYLCIAKNSAGSAMGKTR 2749

Query: 1082 FDAQAVNV--QVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS------ 1133
               Q   V     P  +  EG    L C    +    +T  W +DGQ    A        
Sbjct: 2750 LVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNIT--WDKDGQPVSGAEGKFTIQP 2807

Query: 1134 ---IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAP--------RNLRLTYLL- 1181
               + + N+  +DA +Y C         R  R + L +L  P        R+LRL   L 
Sbjct: 2808 SGELLVKNLEGQDAGTYTCTA--ENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLW 2865

Query: 1182 ---ESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGF 1238
                + G     +  TV+ RP  +      G       A S               D G 
Sbjct: 2866 LRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVS-------------REDSGT 2912

Query: 1239 YSCSARSPLGQANTSLELRLEGVRVILAPEAAV---PEGAPITVTCADPAAHAPTLYTWY 1295
            Y C A + +G+      + ++   V+     +    P G  I + C       P ++ W 
Sbjct: 2913 YVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIH-WI 2971

Query: 1296 HNG---------RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP 1346
             +G           LQ G   SL+     R  AG Y C A++  G  + +   L +  AP
Sbjct: 2972 KDGLPLRGSHLRHQLQNG---SLTIRRTERDDAGRYQCLAENEMGV-AKKVVILVLQSAP 3027

Query: 1347 QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVAR 1406
               V       R+     ++C    EP   +     G+ L  S  + +L  G+       
Sbjct: 3028 VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGS------- 3080

Query: 1407 NALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQVEG 1444
                L +++V  GD  TY C A NLLGS +    L V G
Sbjct: 3081 ----LWLENVETGDAGTYDCVAHNLLGSATARAFLVVRG 3115



 Score =  144 bits (362), Expect = 1e-33
 Identities = 356/1523 (23%), Positives = 529/1523 (34%), Gaps = 293/1523 (19%)

Query: 250  RNILPGELVTLTCQVNSSYPAVSSIKWLK--------DGVRLQTKTGVLHLPQAAWSDAG 301
            R I+      L C  N+  P    + W +        D V +     VL +P     +AG
Sbjct: 1478 REIVENNPAYLYCDTNAIPPP--DLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAG 1535

Query: 302  VYTCQAENGVGS--------LVSPPISL---HIFMAEVQVSPAGPILENQTVTLVCNT-P 349
             Y+C+A N VG         +++PP+ L      + EV V+ +       TV+L C    
Sbjct: 1536 RYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS------TVSLQCPALG 1589

Query: 350  NEAPSDLRYSWYKNHV---------LLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSER 400
            N  P+    SW +N +         +LED     L++  A  AD   Y C  +N  GS  
Sbjct: 1590 NPVPT---ISWLQNGLPFSPSPRLQVLEDGQ--VLQVSTAEVADAASYMCVAENQAGSAE 1644

Query: 401  SGPVSVVVNHPPLTPVL-----TAFLETQAGLVGILHCSVVSEPL---ATLVLSHGGHIL 452
                ++ V  PP    L     TA L +   L   +H     E      +  LS G  + 
Sbjct: 1645 K-LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVF 1703

Query: 453  ASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR 512
                              P +  L++     +DSG Y C A N+ G     +        
Sbjct: 1704 LL----------------PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLS----- 1742

Query: 513  LLISPAAE-----------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP----- 556
            +L+ PA             V  G    LSC +   P P    +WY +G  L         
Sbjct: 1743 VLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTV--TWYKDGQPLVLAQRTQAL 1800

Query: 557  --GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGA 614
              G  L +  A  +D G Y C+    + A        LTV  PP      T      AG+
Sbjct: 1801 RGGQRLEIQEAQVSDKGLYSCKV--SNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGS 1858

Query: 615  GAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRV 674
                  +L C V   P   +  L KDR+   S    G  S  G               R+
Sbjct: 1859 PL----VLTCDVSGVPAPTVTWL-KDRMPVESSAVHGVVSRGG---------------RL 1898

Query: 675  EIHNPLLEEEGLYLCEASNALGNAS----TSATFNGQATVLAIAPSHTLQEGTEANLTCN 730
            ++      + G Y C A N    A      +     +     +A  H + EG E  L C 
Sbjct: 1899 QLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC- 1957

Query: 731  VSREAAGSPA-NFSWFRNGVLWAQ--GPL-------ETVTLLPVARTDAALYACRILTEA 780
               EA G P  + +W ++G    Q  GP         ++ L  +  +DA  Y C     A
Sbjct: 1958 ---EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPA 2014

Query: 781  G--AQLSTPVLLSVLYPPDRPKL---SALLDMGQGHMALFICTV-DSRPLALLALFHGEH 834
            G  A+L T   ++VL PP   +    S  L    G +   +C V  S P+ +  L  G  
Sbjct: 2015 GEDARLHT---VNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDG-- 2069

Query: 835  LLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894
             L   L  +   HG        +   L + ++ L D+G + C A +  G ++ +   QV 
Sbjct: 2070 -LPLPLSQRTLLHG--------SGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV- 2119

Query: 895  GAWVQVSPSPELQE---------GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST---S 942
                QV P  E  E         G  V L C+   GVP      W +DG+PL   +    
Sbjct: 2120 ----QVPPVLEPVEFQNDVVVVRGSLVELPCEAR-GVPLPL-VSWMKDGEPLLSQSLEQG 2173

Query: 943  ATLRFAAITLTQAGAYHCQA-----QAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP 997
             +L+  A+    +G Y C A     +A      ++  P  +  S  P  ++LT      P
Sbjct: 2174 PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLT------P 2227

Query: 998  GRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGA 1057
            G    LLC     P   +   H D    + L+            + + A   LR+     
Sbjct: 2228 GAPMELLCDAQGTPQPNITW-HKDGQALTRLE------------NNSRATRVLRVR---- 2270

Query: 1058 MLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGAT-----VREGQLVNLTCLVWTT 1112
               D G+Y C A +  G    S     QA    V P        +  GQLV L C V   
Sbjct: 2271 ---DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSV-EA 2325

Query: 1113 HPAQLTYTWYQDG-QQRLDAHS--------IPLPNVTVRDATSYRC----GVGPPGRAPR 1159
             PA    TW++DG   + DAH+        + L  ++  D+  Y C      G    A R
Sbjct: 2326 EPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2384

Query: 1160 LSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGR--LLASSTA 1217
            +       +   P  + ++        Q AL+ C  D   PA L      R  L   S  
Sbjct: 2385 VEIHTVPTIRSGPPAVNVSV------NQTALLPCQADG-VPAPLVSWRKDRVPLDPRSPR 2437

Query: 1218 ASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPI 1277
              +     L ++    +D G Y C A +  G      +LR      +L P A  P  + +
Sbjct: 2438 FEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR------VLEPPAIAPSPSNL 2491

Query: 1278 TVTCADPA-------AHAPTLYTWYHNGRWL----QEG-----PAASLSFLVATRAHAGA 1321
            T+T   PA            L  W+ +G+ L    Q+G     P+ +L         +  
Sbjct: 2492 TLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQ 2551

Query: 1322 YSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMA--VIQCTVDSEPPAELAL 1379
            + C   +  G         QV       +     D     MA  V+ C     P   ++ 
Sbjct: 2552 FECVVSNEVGEAHR---LYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSW 2608

Query: 1380 SHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGR 1439
            S  G  L         A G+G+      AL +  Q +P     Y C+A+N  G       
Sbjct: 2609 SKAGAQLG--------ARGSGYRVSPSGALEIG-QALPIHAGRYTCSARNSAGVAHKHVF 2659

Query: 1440 LQVEGARVVAEPGLDVPEGAA---LNLSCRLLGGPGPVGNSTFAWFWNDRRL------HA 1490
            L V+ + VV +P   V    A   + L C   G P P    T  W      +        
Sbjct: 2660 LTVQASPVV-KPLPSVVRAVAEEEVLLPCEASGIPRP----TITWQKEGLNVATGVSTQV 2714

Query: 1491 EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRG 1550
             P   L   H +   AG Y C+A+   G+A      L V  PP     +  +    G   
Sbjct: 2715 LPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGK-TRLVVQVPPVIENGLPDLSTTEGSHA 2773

Query: 1551 ILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGE 1610
             L C+    P  ++T     + V+        AE    +  S   L   ++ L   D G 
Sbjct: 2774 FLPCKARGSPEPNITWDKDGQPVSG-------AEGKFTIQPSGELL---VKNLEGQDAGT 2823

Query: 1611 YICSASNVLGSASTSTYFGVRAL 1633
            Y C+A N +G A    +  +  L
Sbjct: 2824 YTCTAENAVGRARRRVHLTILVL 2846



 Score =  124 bits (311), Expect = 8e-28
 Identities = 264/1141 (23%), Positives = 404/1141 (35%), Gaps = 168/1141 (14%)

Query: 188  SQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSP 247
            SQ+    G GH  TL ++        I  C  +     A     LQV+  P    +L   
Sbjct: 2075 SQRTLLHGSGH--TLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPP----VLEPV 2128

Query: 248  SGRN---ILPGELVTLTCQVNS-SYPAVSSIKWLKDGVRLQTKT----GVLHLPQAAWSD 299
              +N   ++ G LV L C+      P VS   W+KDG  L +++      L L      D
Sbjct: 2129 EFQNDVVVVRGSLVELPCEARGVPLPLVS---WMKDGEPLLSQSLEQGPSLQLEAVGAGD 2185

Query: 300  AGVYTCQAENGVG--------SLVSPPISLHIFMA----EVQVSPAGPILENQTVTLVCN 347
            +G Y+C A +  G        +++ PP   HI  +    E+ ++P  P+       L+C+
Sbjct: 2186 SGTYSCVAVSEAGEARRHFQLTVMEPP---HIEDSGQPTELSLTPGAPM------ELLCD 2236

Query: 348  TPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGS-ERSGPVSV 406
                   ++  +W+K+   L    +++    +    D G Y C  ++  G+ E+S  V V
Sbjct: 2237 AQGTPQPNI--TWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRV 2294

Query: 407  VVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466
                  + P    F+   A    +L CSV +EP   +     G +L   +          
Sbjct: 2295 QAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAH--------- 2345

Query: 467  GTSGPNSLR-LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLIS--PAAEVVE 523
             T  P   R L+++ L   DSG+Y C+A N+ G+ +       +    + S  PA  V  
Sbjct: 2346 -TQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSV 2404

Query: 524  GQAVTLSCRSGLSPTPDARFSWYLNGALLHEG-------PGSSLLLPAASSTDAGSYHCR 576
             Q   L C++   P P    SW  +   L          P  SL +    + DAG Y C 
Sbjct: 2405 NQTALLPCQADGVPAP--LVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCL 2462

Query: 577  ARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQL 636
            A   +SA        L VL PP      + L L A         LL C     P   +  
Sbjct: 2463 A--SNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPA-----LLPCEASGSPKPLVVW 2515

Query: 637  LHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG 696
                + +   L  G             ++  +  LL   +  P  ++   + C  SN +G
Sbjct: 2516 WKDGQKLDFRLQQGA-----------YRLLPSNALL---LTAPGPQDSAQFECVVSNEVG 2561

Query: 697  NAST--SATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNGV---- 749
             A      T +   T+       T+       LTC+    + G PA   SW + G     
Sbjct: 2562 EAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCH----STGIPAPTVSWSKAGAQLGA 2617

Query: 750  ------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSA 803
                  +   G LE    LP+    A  Y C     AG      V L+V   P    L +
Sbjct: 2618 RGSGYRVSPSGALEIGQALPI---HAGRYTCSARNSAGVA-HKHVFLTVQASPVVKPLPS 2673

Query: 804  LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
            ++        L  C     P   +        +AT +  QV   G+           L +
Sbjct: 2674 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ-----------LRI 2722

Query: 864  RELGLGDSGSYRCEATNVLGSS--NTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTG 921
                  D+G+Y C A N  GS+   T L  QV        P     EG    L C+   G
Sbjct: 2723 AHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKAR-G 2781

Query: 922  VPEGTSYRWYRDGQPLQEST-------SATLRFAAITLTQAGAYHCQAQAPGSATTSLAA 974
             PE  +  W +DGQP+  +        S  L    +    AG Y C A+   +A      
Sbjct: 2782 SPE-PNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAE---NAVGRARR 2837

Query: 975  PISLHVSYAPRHVTLTTLMDTGPGRLG---LLLCRVDSDPPAQLRLLHGDRLVASTLQGV 1031
             + L +   P     TTL      RLG    L C     P  ++     DR V    +GV
Sbjct: 2838 RVHLTILVLP---VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT---EGV 2891

Query: 1032 GGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF---DAQAVN 1088
               +G S     AV+             ED G Y+C A N +G+  A +     +A  + 
Sbjct: 2892 SEQDGGSTLQRAAVSR------------EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQ 2939

Query: 1089 VQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH---SIPLPNVTVR--- 1142
             + +       G  + L C+V       +   W +DG     +H    +   ++T+R   
Sbjct: 2940 GEAFSYLVEPVGGSIQLDCVVRGDPVPDIH--WIKDGLPLRGSHLRHQLQNGSLTIRRTE 2997

Query: 1143 --DATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRP 1199
              DA  Y+C      G A ++   + L +  AP        +    G    + C     P
Sbjct: 2998 RDDAGRYQCLAENEMGVAKKV---VILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEP 3054

Query: 1200 PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE 1259
               +    AG+ L +S          L L   +  D G Y C A + LG A     L + 
Sbjct: 3055 TPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3114

Query: 1260 G 1260
            G
Sbjct: 3115 G 3115



 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 210/931 (22%), Positives = 327/931 (35%), Gaps = 140/931 (15%)

Query: 768  DAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALL 827
            D+ LY+CR   +AG       LL VL PP      ++L  G     L +   D       
Sbjct: 98   DSGLYSCRAENQAGTAQRDFHLL-VLTPP------SVLGAGAAQEVLGLAGADVELQCWT 150

Query: 828  ALFHGEHLLATS-LGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN 886
            +      +  T    P +P     Q + +   L++    +G  D G Y+C A +  G   
Sbjct: 151  SGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSPAGQQA 208

Query: 887  TSLFFQVRGA---W-VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTS 942
                 +V      W    +    + E   V L C+   GVP   +  W++DG  L  ST 
Sbjct: 209  RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEAR-GVPT-PNITWFKDGALLPTSTK 266

Query: 943  AT-------LRFAAITLTQAGAYHCQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMD 994
                     L+      + AG Y C+A  A G+A  +    +     Y P  +       
Sbjct: 267  VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-----YVPPTIE------ 315

Query: 995  TGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEI 1054
             G G    ++  V   P A   +  G      +    G P   S    +    + LRLE 
Sbjct: 316  -GAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLES 374

Query: 1055 HGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHP 1114
             G      G+Y C AS+  G+A         +V VQV P   V EG L  +T +V    P
Sbjct: 375  PGEA--SSGLYSCVASSPAGEAVLQ-----YSVEVQVPPQLLVAEG-LGQVTTIVG--QP 424

Query: 1115 AQL----------TYTWYQDG---------QQRLDAHSIPLPNVTVRDATSYRCGVGPPG 1155
             +L          T  W Q+G         Q      ++ + +V +  +  + C      
Sbjct: 425  LELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 484

Query: 1156 RAPRLSRPITLDVLYAPRNLRLT-----YLLESHGGQLALVLCTVDS------RPPAQLA 1204
                    +++   +AP  L +      +  E H    A     V        +PP    
Sbjct: 485  GTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEG 544

Query: 1205 LSHAGRLLASSTAASVPNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVR 1262
                G L    T   V  +L   L++     RDEG Y+C+A +  G++   + L+     
Sbjct: 545  WCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALK----- 599

Query: 1263 VILAPEA-------AVPEGAPITVTCADPAAHAPTLYTWYHNGR----WLQEGPAASLSF 1311
            V++ P         AV E A +T+ C       P + +W+   +    W+  G   S+  
Sbjct: 600  VLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDV-SWFKGHQPVSSWM--GVTVSVDG 656

Query: 1312 LV-----ATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV-I 1365
             V     A  + AG+Y C A +  G+   R   L+V   P+  +  S       +  V +
Sbjct: 657  RVLRIEQAQLSDAGSYRCVASNVAGSTELR-YGLRVNVPPRITLPPSLPGPVLVNTPVRL 715

Query: 1366 QCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYV 1424
             C     P   L    DG  ++ +        GT  +QV      L +    A D   Y 
Sbjct: 716  TCNATGAPSPTLMWLKDGNPVSPA--------GTPGLQVFPGGRVLTLASARASDSGRYS 767

Query: 1425 CTAQNLLGSISTIGRLQVEGARVVA--EPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWF 1482
            C A + +G       LQV     +   E  + V    ++ L C+    P PV     +W+
Sbjct: 768  CVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV----LSWW 823

Query: 1483 WNDRRLHAEPVPTL----AFTHVARAQ---AGMYHCLAELPTGAAA---SAPVMLRVLYP 1532
             + R L   P   L    A   V RA    AG Y C A    G +    +  V +  ++P
Sbjct: 824  KDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFP 883

Query: 1533 PKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLAS 1592
             +    +   E   G    L C     P   ++           QP         HV A 
Sbjct: 884  LRESHTLTVRE---GHPTRLSCECRGVPFPKISWR------KDGQPLPGEGAGLQHVSAV 934

Query: 1593 PNALRVDIEALRPSDQGEYICSASNVLGSAS 1623
               L +    L  + +G Y C  SNV+G++S
Sbjct: 935  GRLLYLGQAQL--AQEGTYTCECSNVVGNSS 963



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 153/634 (24%), Positives = 215/634 (33%), Gaps = 104/634 (16%)

Query: 1061 DEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVRE------GQLVNLTCLVWTTHP 1114
            D G+Y C A N  G  +A  DF    +      GA   +      G  V L C  WT+  
Sbjct: 98   DSGLYSCRAENQAG--TAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQC--WTSGV 153

Query: 1115 AQLTYTWYQDGQQRL----------DAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPI 1164
                  W +D Q  L          D   + +    V D   Y+C    P  A + +R  
Sbjct: 154  PTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP--AGQQARDF 211

Query: 1165 TLDV-----LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAAS 1219
             L V     ++         ++E H   L  +LC     P   +     G LL +ST   
Sbjct: 212  QLRVHAPPTIWGSNETGEVAVMEDH---LVQLLCEARGVPTPNITWFKDGALLPTSTKVV 268

Query: 1220 VPNTLR-LELRGPQPRDEGFYSCSARSPLGQANTSLELRL--------EGVRVILAPEAA 1270
                 R L+L   Q  D G Y+C A + +G A  +  L +         G R  +    A
Sbjct: 269  YTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA 328

Query: 1271 VPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVAT-------RAHAGAYS 1323
               G P+ + C      +PTL +W+H G  + E   + L    +         A +G YS
Sbjct: 329  ---GRPVALECVARGHPSPTL-SWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYS 384

Query: 1324 CQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDG 1383
            C A    G  +    +++V   PQ  V               Q T     P EL     G
Sbjct: 385  CVASSPAG-EAVLQYSVEVQVPPQLLVAEGLG----------QVTTIVGQPLELPCQASG 433

Query: 1384 KVLATSSGVHS--LASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRL 1440
              + T   + +   A     VQVA     L +  V       + C A N  G+      +
Sbjct: 434  SPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEV 493

Query: 1441 QVEGARVVAEPG-LDVPEG-------------AALNLSCRLLGGPGPVGNSTFAWFWNDR 1486
             V G      PG L+VP G             AA +       G  P       W  +  
Sbjct: 494  SVHGEWA---PGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWC-SPG 549

Query: 1487 RLHAEPV---------PTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPT 1537
             L  EP          P L    V     G+Y C A    G +    V L+VL PP    
Sbjct: 550  SLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGES-KREVALKVLVPPNIEP 608

Query: 1538 MMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALR 1597
              V           L+C     P   ++   G + V+S           + V  S +   
Sbjct: 609  GPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSS----------WMGVTVSVDGRV 658

Query: 1598 VDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
            + IE  + SD G Y C ASNV G  ST   +G+R
Sbjct: 659  LRIEQAQLSDAGSYRCVASNVAG--STELRYGLR 690



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 98/436 (22%), Positives = 148/436 (33%), Gaps = 72/436 (16%)

Query: 1232 QPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVP----EGAPITVTCADPAAH 1287
            Q  D G YSC A +  G A     L +     +L   AA       GA + + C      
Sbjct: 95   QEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVP 154

Query: 1288 APTLYTWYHNGRWLQEGPAASLS----FLVATRAHAG---AYSCQAQDAQGTRSSRPAAL 1340
             P +         L  GP   +      L  T +H G    Y C A    G + +R   L
Sbjct: 155  TPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAG-QQARDFQL 213

Query: 1341 QVLYAPQDAVLSSFRDSRARSMAVIQ-------CTVDSEPPAELALSHDGKVLATSSGVH 1393
            +V   P     + +  +    +AV++       C     P   +    DG +L TS+ V 
Sbjct: 214  RVHAPP-----TIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVV 268

Query: 1394 SLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPG- 1452
                G   +Q+ R       Q   AG   Y C A N +G+     RL V     +   G 
Sbjct: 269  YTRGGR-QLQLGR------AQSSDAG--VYTCKASNAVGAAEKATRLDVYVPPTIEGAGG 319

Query: 1453 ----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFW--------NDRRLHAEPVPTLAFTH 1500
                +    G  + L C   G P P    T +W          N+ RL  +    L    
Sbjct: 320  RPYVVKAVAGRPVALECVARGHPSP----TLSWHHEGLPVAESNESRLETDG-SVLRLES 374

Query: 1501 VARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI------LDC 1554
               A +G+Y C+A  P G A     +L+     + P  ++  E  G +  I      L C
Sbjct: 375  PGEASSGLYSCVASSPAGEA-----VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPC 429

Query: 1555 RVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICS 1614
            +    P+ ++               G PAE    V  +     + I+ +     G + C 
Sbjct: 430  QASGSPVPTIQW----------LQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQ 479

Query: 1615 ASNVLGSASTSTYFGV 1630
            A+N  G+A       V
Sbjct: 480  ATNEAGTAGAEVEVSV 495



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 90/346 (26%), Positives = 129/346 (37%), Gaps = 54/346 (15%)

Query: 1299 RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSR 1358
            R L EG   SL F       +G YSC+A++  GT + R   L VL  P  +VL +     
Sbjct: 81   RLLDEGQ--SLHFPRIQEGDSGLYSCRAENQAGT-AQRDFHLLVLTPP--SVLGAGAAQE 135

Query: 1359 ARSMA----VIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQ 1414
               +A     +QC     P  ++  + D +          +  G  H+QV  +   L++ 
Sbjct: 136  VLGLAGADVELQCWTSGVPTPQVEWTKDRQ---------PVLPGGPHLQVQEDGQVLRIT 186

Query: 1415 DVPAGDD-TYVCTAQNLLGSISTIGRLQVEGARVV---AEPG-LDVPEGAALNLSCRLLG 1469
                GD+  Y C A +  G  +   +L+V     +    E G + V E   + L C   G
Sbjct: 187  GSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARG 246

Query: 1470 GPGPVGNSTFAWFWNDRRLHAEPVPT-LAFT------HVARAQ---AGMYHCLAELPTGA 1519
             P P       WF +   L   P  T + +T       + RAQ   AG+Y C A    GA
Sbjct: 247  VPTP----NITWFKDGALL---PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA 299

Query: 1520 AASAPVMLRVLYPPK---TPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASS 1576
            A  A   L V  PP           V+   G    L+C     P  +L+ H     VA S
Sbjct: 300  AEKA-TRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAES 358

Query: 1577 QPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
                   +  +  L SP            +  G Y C AS+  G A
Sbjct: 359  NESRLETDGSVLRLESPG----------EASSGLYSCVASSPAGEA 394



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 82/328 (25%), Positives = 119/328 (36%), Gaps = 37/328 (11%)

Query: 100  LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159
            LL+K+L+ +D+G+Y    E +       V  T++ +   P   T+     L  G  +   
Sbjct: 2811 LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL---PVFTTLPGDRSLRLGDRLWLR 2867

Query: 160  CSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQL 219
            C+          R+ W   D  R VT      E  G   L+    A+S +D G  + C  
Sbjct: 2868 CAARG---SPTPRIGWTVND--RPVTEGVS--EQDGGSTLQ--RAAVSREDSGTYV-CWA 2917

Query: 220  SVANHRAQSEIHLQVKYAP----KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIK 275
                 R Q+   + VK AP    +    L+ P G +I       L C V      V  I 
Sbjct: 2918 ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSI------QLDCVVRGD--PVPDIH 2969

Query: 276  WLKDGVRL-------QTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEV 328
            W+KDG+ L       Q + G L + +    DAG Y C AEN +G      I +       
Sbjct: 2970 WIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVF 3029

Query: 329  QVSPAG-PILENQTVTLVCNTPNEAPSDLRYSWYKNHVL----LEDAHSHTLRLHLATRA 383
            QV P    +     V L C    E    + +      +     L      +L L      
Sbjct: 3030 QVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETG 3089

Query: 384  DTGFYFCEVQNVHGSERSGPVSVVVNHP 411
            D G Y C   N+ GS  +    VV   P
Sbjct: 3090 DAGTYDCVAHNLLGSATARAFLVVRGEP 3117



 Score = 37.4 bits (85), Expect = 0.13
 Identities = 69/298 (23%), Positives = 102/298 (34%), Gaps = 59/298 (19%)

Query: 1365 IQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNAL-----RLQVQDVPAG 1419
            ++C  +  P  E+    D +++    G        G  QV  + L      L    +  G
Sbjct: 38   LECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEG 97

Query: 1420 DD-TYVCTAQNLLGSISTIGRL------QVEGARVVAEP-GLDVPEGAALNLSCRLLGGP 1471
            D   Y C A+N  G+      L       V GA    E  GL    GA + L C   G P
Sbjct: 98   DSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGL---AGADVELQCWTSGVP 154

Query: 1472 GPVGNSTFAWFWNDRRLHAEP------------VPTLAFTHVARAQAGMYHCLAELPTGA 1519
             P         W   R    P            V  +  +HV     G Y C+A  P G 
Sbjct: 155  TPQVE------WTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSPAGQ 206

Query: 1520 AASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILD-------CRVDSEPLASLTLHLGSRL 1572
             A     LRV  PP      ++   E G   +++       C     P  ++T      L
Sbjct: 207  QAR-DFQLRVHAPPT-----IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGAL 260

Query: 1573 VASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGV 1630
            + +S            V+ +    ++ +   + SD G Y C ASN +G+A  +T   V
Sbjct: 261  LPTSTK----------VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 308


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score =  201 bits (511), Expect = 5e-51
 Identities = 332/1499 (22%), Positives = 559/1499 (37%), Gaps = 228/1499 (15%)

Query: 255  GELVTLTCQVNSSYPAVSSIKWLKDGVRL--------QTKTGV--LHLPQAAWSDAGVYT 304
            GE  TL C+V+ + P +  I W K+  +L        Q K  V  L + +   SD G Y+
Sbjct: 7034 GEPATLQCKVDGT-PEIR-ISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYS 7091

Query: 305  CQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQT----------VTLVCNTPNEAPS 354
            C+A+N VG++ S  + +      ++     P    +           V   C      P 
Sbjct: 7092 CKADNSVGAVASSAVLV------IKARKLPPFFARKLKDVHETLGFPVAFECRINGSEP- 7144

Query: 355  DLRYSWYKNHVLLED--------AHS-HTLRLHLATRADTGFYFCEVQNVHGSERSGPVS 405
             L+ SWYK+ VLL+D         H+  TL++    ++  G Y C   N  G+  S    
Sbjct: 7145 -LQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKL 7203

Query: 406  VVVNH--PPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP 463
            ++  H  PP   +    ++   G  G   C V       +         A  + +     
Sbjct: 7204 ILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITW-------AKDNREIRPGG 7256

Query: 464  RFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLIS---PAAE 520
             +  T   N+  L +  + + D+G+Y C A+N  G  + +           I    P+  
Sbjct: 7257 NYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRI 7316

Query: 521  VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPG---------SSLLLPAASSTDAG 571
            V + +     C+ G SP  + +  WY +   + E            + L +   S  D+G
Sbjct: 7317 VKQDEFTRYECKIGGSP--EIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSG 7374

Query: 572  SYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPP 631
             Y C A   H+A+G +S +  T L     P F  +        GA     L C +   PP
Sbjct: 7375 DYTCEA---HNAAGSASSS--TSLKVKEPPIFRKKPHPIETLKGADVH--LECELQGTPP 7427

Query: 632  ARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEA 691
              +   +KD+     L SG           + K+     L  + I N    + G Y C+A
Sbjct: 7428 FHVSW-YKDK---RELRSG----------KKYKIMSENFLTSIHILNVDAADIGEYQCKA 7473

Query: 692  SNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFRN---- 747
            +N +G+ +   +   +A    +     +       +    + E A  P +  WF++    
Sbjct: 7474 TNDVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGA-EPISVVWFKDKGEI 7532

Query: 748  ----GVLWAQGPLETVTLLPVARTD---AALYACRILTEAGAQLSTPVLLSVLYPPDRPK 800
                  +W     E +  L  +R +   A  Y C+I  +AG Q      LSVL P    +
Sbjct: 7533 VRESDNIWISYS-ENIATLQFSRVEPANAGKYTCQIKNDAGMQ-ECFATLSVLEPATIVE 7590

Query: 801  LSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLK 860
                + +  G      CTV   P      F          G ++ S  +++         
Sbjct: 7591 KPESIKVTTGDTCTLECTVAGTPELSTKWFKD--------GKELTSDNKYKISFFNKVSG 7642

Query: 861  LEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE-----GQAVVLS 915
            L++  +   DSG Y  E  N +G  + +   QV    V  S + +L+E     G +VV+ 
Sbjct: 7643 LKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVME 7702

Query: 916  CQVHTGVPEGTSYRWYRDGQPLQES----TSATLRFAAITL-----TQAGAYHCQAQAPG 966
            C+V+   P   S  W+ +G  +       T+ T    A+T+     + +G Y C A    
Sbjct: 7703 CKVYGSPPISVS--WFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNM- 7759

Query: 967  SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVAS 1026
            + +   +AP++  V   P  V     MD   G        V   PP  +    G   +  
Sbjct: 7760 AGSDECSAPLT--VREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVP 7817

Query: 1027 TLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF--DA 1084
                         R +V++  +   LE+        G Y C  SN  G+AS +      A
Sbjct: 7818 -----------GDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKA 7866

Query: 1085 QAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDG-----QQRLDAHS------ 1133
             A  V+     ++ +G+ + L      T P  ++ TW ++G      QR +  +      
Sbjct: 7867 PAKFVKRLNDYSIEKGKPLILEGTFTGTPP--ISVTWKKNGINVTPSQRCNITTTEKSAI 7924

Query: 1134 IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLC 1193
            + +P+ TV DA  Y C +         S  I   +L  P  ++    ++   G  A + C
Sbjct: 7925 LEIPSSTVEDAGQYNCYIENASGKDSCSAQIL--ILEPPYFVKQLEPVKVSVGDSASLQC 7982

Query: 1194 TVDSRPPAQLALSHAGRLLASSTAASVP---NTLRLELRGPQPRDEGFYSCSARSPLGQA 1250
             +   P   ++       L  +T   +    N   L        D G Y C A + +G+ 
Sbjct: 7983 QLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEV 8042

Query: 1251 NTSLELRLEGVRVILAPEAAVPE-----GAPITVTCADPAAHAPTLYTWYHNGRWLQEGP 1305
            + S  L ++  ++  +    + +     G P+   CA   +  P   +WY +G+ L++ P
Sbjct: 8043 SASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSE-PISVSWYKDGKPLKDSP 8101

Query: 1306 AASLSFLVAT---------RAHAGAYSCQAQDAQGTRSS----------RPAALQVLYAP 1346
                SFL  T         R+ AG YSC A +  G+ SS           P    +  AP
Sbjct: 8102 NVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAP 8161

Query: 1347 QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVAR 1406
             DAV+    D         +C V    P +++ + D + + +         G   +    
Sbjct: 8162 VDAVVGESAD--------FECHVTGTQPIKVSWAKDSREIRSG--------GKYQISYLE 8205

Query: 1407 NALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQVEGARVVAE------PGLDVPEGA 1459
            N+  L V  V  GD   Y C A N +G  S   +L ++   +           ++  EG 
Sbjct: 8206 NSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGN 8265

Query: 1460 ALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTH------VARA---QAGMYH 1510
            +  L  R+ G   P+   T AW+ N+  +       + F +      V +A    AG+Y 
Sbjct: 8266 SFKLEGRVAGSQ-PI---TVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYT 8321

Query: 1511 CLAELPTGAA--ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVD-SEPLASLTLH 1567
            C      G+A   S+ V+     PP     +  V    G    L C V  SEP+    L 
Sbjct: 8322 CKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLK 8381

Query: 1568 LGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTST 1626
             G  +         P++      AS  A+ +++  +  +D G+Y+C ASNV GS +T +
Sbjct: 8382 AGREI--------KPSDRCSFSFASGTAV-LELRDVAKADSGDYVCKASNVAGSDTTKS 8431



 Score =  186 bits (472), Expect = 2e-46
 Identities = 357/1650 (21%), Positives = 601/1650 (36%), Gaps = 239/1650 (14%)

Query: 102  LKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCS 161
            + D++ EDSGSY+    +++V   SD   T + + E P       P +++ GT     C 
Sbjct: 3797 ITDVKVEDSGSYSCE-AVNDVG--SDSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCE 3853

Query: 162  TPYVCLQEQVRLQW-QGQDPARSVTFNSQKFEPTGVGHLETLHM-AMSWQDHGRILRCQL 219
               V       + W + +   RS    S+K+       L  L + + +  D G     + 
Sbjct: 3854 ---VSGTGPFEISWFKDKKQIRS----SKKYRLFSQKSLVCLEIFSFNSADVGEY---EC 3903

Query: 220  SVANHRAQS---EIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW 276
             VAN   +      HL +K  P  VK +        L G+ VTL   V  S P   S+ W
Sbjct: 3904 VVANEVGKCGCMATHL-LKEPPTFVKKV---DDLIALGGQTVTLQAAVRGSEPI--SVTW 3957

Query: 277  LK-------DG-VRLQTKTGV--LHLPQAAWSDAGVYTCQAENGVGS-------LVSPPI 319
            +K       DG +++    GV  L +P    S  G YTC AEN  GS       +V  P 
Sbjct: 3958 MKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPA 4017

Query: 320  SLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHT----- 374
             +      +QV+   P     TV     TP     +L+  WYK+   L  +  +      
Sbjct: 4018 KIIERAELIQVTAGDPATLEYTVA---GTP-----ELKPKWYKDGRPLVASKKYRISFKN 4069

Query: 375  ----LRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVG- 429
                L+ + A   D+G Y  E+ N  GS        V++   + P  T  L     +V  
Sbjct: 4070 NVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRD-IAPFFTKPLRNVDSVVNG 4128

Query: 430  --ILHCSVV-SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDS 486
               L C +  S P+       G  I AS   D        GT+      LEI  ++  D+
Sbjct: 4129 TCRLDCKIAGSLPMRVSWFKDGKEIAAS---DRYRIAFVEGTAS-----LEIIRVDMNDA 4180

Query: 487  GEYKCSATNSLGNATST--LDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFS 544
            G + C ATNS+G+  S+  L      + +    + +V+ G AV L  +S    +      
Sbjct: 4181 GNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCL--KSTFQGSTPLTIR 4238

Query: 545  WYLNGALLHEGPG---------SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVL 595
            W+     L  G           SSL L    ++D+G+Y C+    + A G    A L V 
Sbjct: 4239 WFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKV--SNVAGGVECSANLFVK 4296

Query: 596  YPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCST 655
             P    TF  +L+  +     G    L C+V   PP ++     DR +  S         
Sbjct: 4297 EP---ATFVEKLE-PSQLLKKGDATQLACKVTGTPPIKITWFANDREIKES--------- 4343

Query: 656  CGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATF---NGQATVLA 712
                  RM   ++  +LR  + +  +E+ G Y+CEA N  G+   S+             
Sbjct: 4344 ---SKHRMSFVESTAVLR--LTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKE 4398

Query: 713  IAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNGVL---------WAQGPLETVTLL 762
              P   L+E     L      E AG+P    +WF++  +         + Q  L ++ +L
Sbjct: 4399 FKPIEVLKEYDVMLLA-----EVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQIL 4453

Query: 763  PVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTV-DS 821
                 DA  Y CR+  E G+ + +   +++  PP   K        +G  A F  T+  S
Sbjct: 4454 KFVAADAGEYQCRVTNEVGSSICS-ARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGS 4512

Query: 822  RPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNV 881
             P+ +  L   +         ++      +   E N   L +  + +   G Y C+A N 
Sbjct: 4513 LPITVTWLKDSD---------EITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKND 4563

Query: 882  LGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQ--- 938
             G    S    V+        +  +   Q    + QV     +  + +W++DGQ L    
Sbjct: 4564 AGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGS 4623

Query: 939  ------ESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTL 992
                    T + L+  +     +G Y  + Q     ++  A    L +   P        
Sbjct: 4624 KYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKK 4683

Query: 993  MDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRL 1052
            MD+  G    L C V    P  ++    D+ ++           +S +   +   NT  L
Sbjct: 4684 MDSIKGSFIDLECIVAGSHPISIQWFKDDQEIS-----------ASEKYKFSFHDNTAFL 4732

Query: 1053 EIHGAMLEDEGVYICEASNTLG--QASASADFDAQAVNVQVWPGATVREGQLVNLTCLVW 1110
            EI      D G Y C A+N  G  Q S           V+      V     V L  LV 
Sbjct: 4733 EISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVG 4792

Query: 1111 TTHPAQLTYTWYQDGQQRLD-----------AHSIPLPNVTVRDATSYRCGVGPPGRAPR 1159
             T P  +T  W++D ++              + S+ L      D+ +Y C +        
Sbjct: 4793 GTAP--MTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLS--NDVGT 4848

Query: 1160 LSRPITLDVLYAPRNLRL-TYLLESHGGQLALVLCTVDSRPPAQLALSHAGR---LLASS 1215
             +   TL V   P+ ++  + +L    GQ     C +   P  +++    G     +   
Sbjct: 4849 ATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKH 4908

Query: 1216 TAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGA 1275
              + +      ++ G +  + G Y C AR+  G A+ S+EL+++       P   + E  
Sbjct: 4909 GISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVK------EPPTFIRELK 4962

Query: 1276 PITVTC-------ADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVAT---------RAHA 1319
            P+ V          +     P   TW  N R ++     +L+  V+           +  
Sbjct: 4963 PVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDT 5022

Query: 1320 GAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRA--RSMAVIQCTVDSEPPAEL 1377
            G Y C   +  G+ S    + +V      + +    ++    +S A  Q TV   PP  +
Sbjct: 5023 GEYQCIVSNEGGSCS---CSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISI 5079

Query: 1378 ALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAG-DDTYVCTAQNLLGSIST 1436
                D ++L     V        ++    +   LQ++ V  G    Y C A+N  G    
Sbjct: 5080 TWLKDDQILDEDDNV--------YISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERC 5131

Query: 1437 IGRLQVEGARVVAE--PGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVP 1494
               L V+    + E    +DV E   + L C + G P         W  + +++      
Sbjct: 5132 YAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTP----ELKVKWLKDGKQIVPSRYF 5187

Query: 1495 TLAFTH---------VARAQAGMYHCLAELPTGAAASAPVMLRVL---YPPKTPTMMVFV 1542
            +++F +         V +  +G Y    E   G ++S    LRVL    PP     +  +
Sbjct: 5188 SMSFENNVASFRIQSVMKQDSGQYTFKVENDFG-SSSCDAYLRVLDQNIPPSFTKKLTKM 5246

Query: 1543 EPEGGLRGILDCRVD-SEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIE 1601
            +   G    ++C+V  S P+++     G  +  S++           ++    ++ +++ 
Sbjct: 5247 DKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAK---------YRLVCHERSVSLEVN 5297

Query: 1602 ALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
             L   D   Y C  SNV G  + S    V+
Sbjct: 5298 NLELEDTANYTCKVSNVAGDDACSGILTVK 5327



 Score =  186 bits (472), Expect = 2e-46
 Identities = 370/1748 (21%), Positives = 630/1748 (36%), Gaps = 274/1748 (15%)

Query: 27   QDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEARFRGR 86
            +DV  + G+ +++ C  S  A + V       W+ D +   ++VS    PK        +
Sbjct: 6748 KDVNAILGASVVLECRVSGSAPISVG------WFQDGN---EIVS---GPKC-------Q 6788

Query: 87   TEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIAS 146
            + F  N    VC L L  L+P D+G Y     ++     SD    ++TV E P       
Sbjct: 6789 SSFSEN----VCTLNLSLLEPSDTGIYTC---VAANVAGSDECSAVLTVQEPPSFEQTPD 6841

Query: 147  PVELLEGTEVDFNCSTPYVCLQEQVRLQW----QGQDPARSVTFNSQKFEPTGVGHLETL 202
             VE+L G  + F   T  +      +++W    +   P  S   + + F    V  LE  
Sbjct: 6842 SVEVLPGMSLTF---TSVIRGTPPFKVKWFKGSRELVPGESCNISLEDF----VTELELF 6894

Query: 203  HMA-MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLT 261
             +  +   D+     C ++     A    HL VK     VK L   S   +  G  + L 
Sbjct: 6895 EVQPLESGDYS----CLVTNDAGSASCTTHLFVKEPATFVKRLADFS---VETGSPIVLE 6947

Query: 262  CQVNSSYPAVSSIKWLKD----------GVRLQTKTGVLHLPQAAWSDAGVYTCQAENGV 311
                 + P   S+ W+KD           + +  K+ +L + ++   D   Y+C  EN  
Sbjct: 6948 ATYTGTPPI--SVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEA 7005

Query: 312  G--------SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKN 363
            G        S++ PP     F+  ++   A   +  +  TL C    +   ++R SWYK 
Sbjct: 7006 GQDICEALVSVLEPPY----FIEPLEHVEA---VIGEPATLQCKV--DGTPEIRISWYKE 7056

Query: 364  HVLLEDAHSHTLR---------LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNH--PP 412
            H  L  A ++ ++         ++    +D G Y C+  N  G+  S  V V+     PP
Sbjct: 7057 HTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLPP 7116

Query: 413  LTPVLTAFLETQAGLVGILHCSVV-SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGP 471
                    +    G      C +  SEPL       G         D++    F      
Sbjct: 7117 FFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDG----VLLKDDANLQTSFVH---- 7168

Query: 472  NSLRLEIRDLEETDSGEYKCSATNSLGNATST----LDFHANAARLLISPAA-EVVEGQA 526
            N   L+I   +++  G+Y CSA+N LG A+S+    L  H       + P + ++  G++
Sbjct: 7169 NVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGES 7228

Query: 527  VTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASST---------DAGSYHCRA 577
             T  C   ++ T   + +W  +   +  G    + L   ++T         DAG Y C A
Sbjct: 7229 GTFKCH--VTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYA 7286

Query: 578  RDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLL 637
               + A   S  A L V  PPR   F  +L+               C++   P  ++ L 
Sbjct: 7287 --SNIAGKDSCSAQLGVQEPPR---FIKKLEPSRI-VKQDEFTRYECKIGGSPEIKV-LW 7339

Query: 638  HKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGN 697
            +KD                   S + +++   ++  +E+HN  +E+ G Y CEA NA G+
Sbjct: 7340 YKDETEIQE-------------SSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGS 7386

Query: 698  ASTSATFNGQATVLAIAPSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRNG------- 748
            AS+S +   +   +     H ++  +G + +L C +       P + SW+++        
Sbjct: 7387 ASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQ---GTPPFHVSWYKDKRELRSGK 7443

Query: 749  --VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLD 806
               + ++  L ++ +L V   D   Y C+   + G+      +     P    KLS +  
Sbjct: 7444 KYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDIST 7503

Query: 807  MGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVREL 866
            +    + L      + P++++             G  V            N   L+   +
Sbjct: 7504 VVGKEVQLQTTIEGAEPISVVWF--------KDKGEIVRESDNIWISYSENIATLQFSRV 7555

Query: 867  GLGDSGSYRCEATNVLGSSN--TSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPE 924
               ++G Y C+  N  G      +L        V+   S ++  G    L C V  G PE
Sbjct: 7556 EPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTV-AGTPE 7614

Query: 925  GTSYRWYRDGQPLQESTS---------ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAP 975
              S +W++DG+ L              + L+   +  + +G Y  + Q P    +  A  
Sbjct: 7615 -LSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTA-- 7671

Query: 976  ISLHVSYAPRHVTLTTLMDTGPGRLG---LLLCRVDSDPPAQLRLLHGDRLVASTLQGVG 1032
             SL VS      + T  +    G  G   ++ C+V   PP  +   H            G
Sbjct: 7672 -SLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFH-----------EG 7719

Query: 1033 GPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVN--VQ 1090
                S  +    +  NT  L ++     D G Y C A+N  G    SA    +     VQ
Sbjct: 7720 NEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQ 7779

Query: 1091 VWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL-----------DAHSIPLPNV 1139
                  V  G  V  T +V  T P   + +W++   + +               + L +V
Sbjct: 7780 KPDPMDVLTGTNVTFTSIVKGTPP--FSVSWFKGSSELVPGDRCNVSLEDSVAELELFDV 7837

Query: 1140 TVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRP 1199
                +  Y C V     A + S    L +    + ++         G+  ++  T    P
Sbjct: 7838 DTSQSGEYTCIVS--NEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTP 7895

Query: 1200 PAQLALSHAGRLLASSTAASVPNTLR---LELRGPQPRDEGFYSCSARSPLGQANTSLEL 1256
            P  +     G  +  S   ++  T +   LE+      D G Y+C   +  G+ + S ++
Sbjct: 7896 PISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQI 7955

Query: 1257 RLEGVRVILAPEAAVPEGAPITVTCADPA------AHAPTL-YTWYHNGRWLQ------- 1302
                  +IL P   V +  P+ V+  D A      A  P +  +WY     L+       
Sbjct: 7956 ------LILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKM 8009

Query: 1303 --EGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSF----RD 1356
                  A+L F       +G Y C+A+++ G  S    A   L   +  +  SF    RD
Sbjct: 8010 HFRNNVATLVFNQVDINDSGEYICKAENSVGEVS----ASTFLTVQEQKLPPSFSRQLRD 8065

Query: 1357 --SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVH-SLASGTGHVQVARNALRLQV 1413
                     V  C +    P  ++   DGK L  S  V  S    T  + + +    L  
Sbjct: 8066 VQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAG 8125

Query: 1414 QDVPAGDDTYVCTAQNLLGSISTIGRL-QVEGARV----VAEPGLDVPEGAALNLSCRLL 1468
            Q        Y CTA N +GS S+  RL   EG       +    +D   G + +  C + 
Sbjct: 8126 Q--------YSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVT 8177

Query: 1469 GGPGPVGNSTFAWFWNDRRL---------HAEPVPTLAFTHVARAQAGMYHCLAELPTG- 1518
             G  P+     +W  + R +         + E    L    V +  +G Y C A    G 
Sbjct: 8178 -GTQPI---KVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGK 8233

Query: 1519 --AAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRV-DSEPLASLTLHLGSRLVAS 1575
                A   +  R++ P  T  +   VE   G    L+ RV  S+P+          +  +
Sbjct: 8234 DSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPT 8293

Query: 1576 SQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRALHR 1635
            S         +  +    N L + +     +D G Y C  SN  GSA  ++   ++   +
Sbjct: 8294 S---------NCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKK 8344

Query: 1636 LHQFQQLL 1643
               F Q L
Sbjct: 8345 PPVFDQHL 8352



 Score =  183 bits (464), Expect = 1e-45
 Identities = 362/1735 (20%), Positives = 619/1735 (35%), Gaps = 234/1735 (13%)

Query: 26   PQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEARFRG 85
            P  V  +KGS +++ C  S     EV      +W  D   ++QV              R 
Sbjct: 6464 PSPVGALKGSDVILQCEISGTPPFEV------VWVKD---RKQV--------------RN 6500

Query: 86   RTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIA 145
              +F    +H   +L + +L+  D G Y+ +   +EV   SD     V   E PR     
Sbjct: 6501 SKKFKITSKHFDTSLHILNLEASDVGEYHCK-ATNEVG--SDTCSCSVKFKEPPRFVKKL 6557

Query: 146  SPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMA 205
            S    L G  V+             V L+ +G+     V   S+    + + ++ TL + 
Sbjct: 6558 SDTSTLIGDAVELRAIVEGFQPISVVWLKDRGE-----VIRESENTRISFIDNIATLQLG 6612

Query: 206  MSWQDHGRILRCQL-SVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQV 264
                 +     CQ+ + A  R  S +   ++ A    +I+  P    +  G    L C V
Sbjct: 6613 SPEASNSGKYICQIKNDAGMRECSAVLTVLEPA----RIIEKPEPMTVTTGNPFALECVV 6668

Query: 265  NSSYPAVSSIKWLKDGVRLQT----------KTGVLHLPQAAWSDAGVYTCQAENGVGSL 314
              + P +S+ KW KDG  L            K   L +P A  SD G+Y+ + +N VG  
Sbjct: 6669 TGT-PELSA-KWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKS 6726

Query: 315  VSPPISLHIFMAEVQVSPAGPILE-----NQTVTLVCNTPNEAPSDLRYSWYKNHVL--- 366
             +  +S+H+    V  S    + +       +V L C     AP  + +    N ++   
Sbjct: 6727 -NCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGP 6785

Query: 367  -LEDAHSH---TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLE 422
              + + S    TL L L   +DTG Y C   NV GS+    V + V  PP        +E
Sbjct: 6786 KCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAV-LTVQEPPSFEQTPDSVE 6844

Query: 423  TQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLE 482
               G+       +   P   +    G   L      +     F          LE+ +++
Sbjct: 6845 VLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFV-------TELELFEVQ 6897

Query: 483  ETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDAR 542
              +SG+Y C  TN  G+A+ T           +   A+        +   +  + TP   
Sbjct: 6898 PLESGDYSCLVTNDAGSASCTTHLFVKEPATFVKRLADFSVETGSPIVLEATYTGTPPIS 6957

Query: 543  FSWYLNGALLHEGPGSSLLLPAASST---------DAGSYHCRARDGHSASGPSSPAVLT 593
             SW  +  L+ +    S+ +   S+          D   Y C   +   A      A+++
Sbjct: 6958 VSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIEN--EAGQDICEALVS 7015

Query: 594  VLYPPR--QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGG 651
            VL PP   +P       L+   A  G    L C+VD  P  R+    +     T L S  
Sbjct: 7016 VLEPPYFIEP-------LEHVEAVIGEPATLQCKVDGTPEIRISWYKEH----TKLRS-- 7062

Query: 652  GCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVL 711
                    +P  K+    N+  + I+     + G Y C+A N++G  ++SA    +A  L
Sbjct: 7063 --------APAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKL 7114

Query: 712  AIAPSHTLQE-----GTEANLTCNVSREAAGSPANFSWFRNGVLWAQGP------LETVT 760
                +  L++     G      C ++      P   SW+++GVL           +  V 
Sbjct: 7115 PPFFARKLKDVHETLGFPVAFECRIN---GSEPLQVSWYKDGVLLKDDANLQTSFVHNVA 7171

Query: 761  LLPVARTDAA---LYACRILTEAGAQLSTPVLLSVLY--PPDRPKLSALLDMGQGHMALF 815
             L + +TD +    Y C      G   S+  L+   +  PP        +D+  G    F
Sbjct: 7172 TLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTF 7231

Query: 816  ICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYR 875
             C V       +               ++   G ++     N+  L V ++G GD+G Y 
Sbjct: 7232 KCHVTGTAPIKITWAKDNR--------EIRPGGNYKMTLVENTATLTVLKVGKGDAGQYT 7283

Query: 876  CEATNVLGSSNTSLFFQVRGA---WVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYR 932
            C A+N+ G  + S    V+       ++ PS  +++ +     C++  G PE     WY+
Sbjct: 7284 CYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIG-GSPE-IKVLWYK 7341

Query: 933  DGQPLQESTS---------ATLRFAAITLTQAGAYHCQAQ-APGSATTSLAAPISLHVSY 982
            D   +QES+          A L    +++  +G Y C+A  A GSA++S     SL V  
Sbjct: 7342 DETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSST----SLKVKE 7397

Query: 983  APRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLH 1042
             P        ++T  G    L C +   PP  +      R + S  +     E     +H
Sbjct: 7398 PPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIH 7457

Query: 1043 VAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVN--VQVWPGATVREG 1100
            +        L +  A   D G Y C+A+N +G  +       +A    V+     +   G
Sbjct: 7458 I--------LNVDAA---DIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTVVG 7506

Query: 1101 QLVNLTCLVWTTHPAQLTYTWYQDGQQRL------------DAHSIPLPNVTVRDATSYR 1148
            + V L   +    P  ++  W++D  + +            +  ++    V   +A  Y 
Sbjct: 7507 KEVQLQTTIEGAEP--ISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYT 7564

Query: 1149 CGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHA 1208
            C +     A       TL VL     +     ++   G    + CTV   P         
Sbjct: 7565 CQI--KNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKD 7622

Query: 1209 GRLLASSTAASVP---NTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265
            G+ L S     +        L++    P D G YS   ++P+G+ + +  L++    V  
Sbjct: 7623 GKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPP 7682

Query: 1266 APEAAVPE-----GAPITVTCADPAAHAPTLYTWYHNGRWLQEGP---------AASLSF 1311
            +    + E     G+ + + C    +  P   +W+H G  +  G            +L+ 
Sbjct: 7683 SFTRKLKETNGLSGSSVVMECKVYGS-PPISVSWFHEGNEISSGRKYQTTLTDNTCALTV 7741

Query: 1312 LVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDS 1371
             +   + +G Y+C A +  G+     A L V   P         D    +       V  
Sbjct: 7742 NMLEESDSGDYTCIATNMAGSDECS-APLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKG 7800

Query: 1372 EPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNL 1430
             PP  ++       L      +        V +  +   L++ DV       Y C   N 
Sbjct: 7801 TPPFSVSWFKGSSELVPGDRCN--------VSLEDSVAELELFDVDTSQSGEYTCIVSNE 7852

Query: 1431 LGSISTIGRLQVEGARVVAEPGLD--VPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRL 1488
             G  S    L ++      +   D  + +G  L L     G P P+  +     W    +
Sbjct: 7853 AGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTP-PISVT-----WKKNGI 7906

Query: 1489 HAEPVPTLAFTHVARA-----------QAGMYHCLAELPTGAAASAPVMLRVLYPPKTPT 1537
            +  P      T   ++            AG Y+C  E  +G  + +  +L +L PP    
Sbjct: 7907 NVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQIL-ILEPPYFVK 7965

Query: 1538 MMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALR 1597
             +  V+   G    L C++   P   ++ + G   +  +         ++  L      +
Sbjct: 7966 QLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFN---Q 8022

Query: 1598 VDIEALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGL 1652
            VDI     +D GEYIC A N +G  S ST+  V+       F + L  +   VGL
Sbjct: 8023 VDI-----NDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGL 8072



 Score =  174 bits (442), Expect = 5e-43
 Identities = 362/1729 (20%), Positives = 631/1729 (36%), Gaps = 258/1729 (14%)

Query: 24   SSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEARF 83
            S P  V+ +K + + + C  S     EV      +WY D   +RQ+ S S   K+    F
Sbjct: 5521 SFPPIVETLKNAEVSLECELSGTPPFEV------VWYKD---KRQLRS-SKKYKIASKNF 5570

Query: 84   RGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPT 143
                       H   ++L  ++   D G Y+ + + +EV   SD     V + E PR  +
Sbjct: 5571 -----------HTSIHIL--NVDTSDIGEYHCKAQ-NEVG--SDTCVCTVKLKEPPRFVS 5614

Query: 144  IASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLH 203
              + + ++ G   +   S       + + +QW  +     V   S+    T V ++ TL 
Sbjct: 5615 KLNSLTVVAGEPAELQASIEGA---QPIFVQWLKEK--EEVIRESENIRITFVENVATLQ 5669

Query: 204  MAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQ 263
             A +   +     CQ+       ++   L V    +   I+       +  GE  TL C+
Sbjct: 5670 FAKAEPANAGKYICQIKNDGGMRENMATLMVL---EPAVIVEKAGPMTVTVGETCTLECK 5726

Query: 264  VNSSYPAVSSIKWLKDGVRLQT----------KTGVLHLPQAAWSDAGVYTCQAENGVGS 313
            V  + P +S ++W KDG  L +          K   L +      DAG YT Q +N VG 
Sbjct: 5727 VAGT-PELS-VEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGK 5784

Query: 314  LVSPPISLHIFMAEVQVSPA--------GPILENQTVTLVCNTPNEAPSDLRYSWYKNHV 365
                 +   + +++  V P+        G +L    + L C     +P  +  +W+    
Sbjct: 5785 SSCTAV---VDVSDRAVPPSFTRRLKNTGGVLGASCI-LECKVAGSSP--ISVAWFHEKT 5838

Query: 366  LLEDAHSH---------TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPV 416
             +     +         TL+L+    +D G Y C   NV GS+    V + V  PP    
Sbjct: 5839 KIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAV-LTVQEPPSFVK 5897

Query: 417  LTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRL 476
                LE   G        +   P   +    G   L    GD  +   F  T       L
Sbjct: 5898 EPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVK--GDRCNI-YFEDTVA----EL 5950

Query: 477  EIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAE--VVEGQAVTLSCRSG 534
            E+ +++ + SGEY C  +N+ G A+ T           +   ++  V  G+++ L   S 
Sbjct: 5951 ELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILE--ST 6008

Query: 535  LSPTPDARFSWYLNGALLHEGPGSSL-------LLPAASST--DAGSYHCRARDGHSASG 585
             + T     +W  +G  +      ++       +L   +ST  DAG Y C   +   A  
Sbjct: 6009 YTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIEN--EAGR 6066

Query: 586  PSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVAT 645
                A+++ L PP   T     +L+   A  G    L C+V   P   +     D  +  
Sbjct: 6067 DVCGALVSTLEPPYFVT-----ELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRP 6121

Query: 646  SLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFN 705
            +              P  +     N+  +  +   + + G Y C+A N++G AS+   F 
Sbjct: 6122 T--------------PEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFR 6167

Query: 706  GQATVLAIAPSHTLQE-----GTEANLTCNVSREAAGSPANFSWFRNGVLWAQGP----- 755
             Q   L  + +  L++     G    LTC ++  A   P    W+R+GVL          
Sbjct: 6168 IQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSA---PIQVCWYRDGVLLRDDENLQTS 6224

Query: 756  -LETVTLLPVARTD---AALYACRILTEAGAQLSTPVLLSVLYPPDRPKLS---ALLDMG 808
             ++ V  L + +TD   +  Y+C      G   S+   L+   P   P        +D+ 
Sbjct: 6225 FVDNVATLKILQTDLSHSGQYSCSASNPLGTA-SSSARLTAREPKKSPFFDIKPVSIDVI 6283

Query: 809  QGHMALFICTVD-SRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELG 867
             G  A F C V  ++P+          +  +    ++   G +      N+  L + ++G
Sbjct: 6284 AGESADFECHVTGAQPM---------RITWSKDNKEIRPGGNYTITCVGNTPHLRILKVG 6334

Query: 868  LGDSGSYRCEATNVLGSSNTSLFFQVRGA---WVQVSPSPELQEGQAVVLSCQVHTGVPE 924
             GDSG Y C+ATN +G    S    V+       ++  S   ++G+++ L C++ +G PE
Sbjct: 6335 KGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKI-SGSPE 6393

Query: 925  GTSYRWYRDGQPLQESTSATLRF----AAITLTQA-----GAYHCQA-QAPGSATTSLAA 974
                 W+R+   L ES    + F    A +T+ +A     G Y C+A    G A+ S A 
Sbjct: 6394 -IKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTA- 6451

Query: 975  PISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034
               L V   P      + +    G   +L C +   PP ++  +   + V ++ +     
Sbjct: 6452 ---LTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITS 6508

Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQ--ASASADFDAQAVNVQVW 1092
            +     LH+      L LE       D G Y C+A+N +G    S S  F      V+  
Sbjct: 6509 KHFDTSLHI------LNLE-----ASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKL 6557

Query: 1093 PGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL------------DAHSIPLPNVT 1140
               +   G  V L  +V    P  ++  W +D  + +            +  ++ L +  
Sbjct: 6558 SDTSTLIGDAVELRAIVEGFQP--ISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPE 6615

Query: 1141 VRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPP 1200
              ++  Y C +         S  +T  VL   R +     +    G    + C V   P 
Sbjct: 6616 ASNSGKYICQIKNDAGMRECSAVLT--VLEPARIIEKPEPMTVTTGNPFALECVVTGTPE 6673

Query: 1201 AQLALSHAGRLLASST---AASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLEL- 1256
                    GR L++ +      +     L++   +  D+G YS   ++ +G++N ++ + 
Sbjct: 6674 LSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVH 6733

Query: 1257 ------------RLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEG 1304
                        +L+ V  IL        GA + + C   +  AP    W+ +G  +  G
Sbjct: 6734 VSDRIVPPSFIRKLKDVNAIL--------GASVVLECR-VSGSAPISVGWFQDGNEIVSG 6784

Query: 1305 PAASLSF---------LVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR 1355
            P    SF          +   +  G Y+C A +  G+     A L V   P         
Sbjct: 6785 PKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGS-DECSAVLTVQEPPSFEQTPDSV 6843

Query: 1356 DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVH-SLASGTGHVQVARNALRLQVQ 1414
            +            +   PP ++      + L      + SL      +++       +VQ
Sbjct: 6844 EVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFVTELEL------FEVQ 6897

Query: 1415 DVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLD--VPEGAALNLSCRLLGGPG 1472
             + +GD  Y C   N  GS S    L V+      +   D  V  G+ + L     G P 
Sbjct: 6898 PLESGD--YSCLVTNDAGSASCTTHLFVKEPATFVKRLADFSVETGSPIVLEATYTGTP- 6954

Query: 1473 PVGNSTFAWFWNDRRLHAEPVPTLAFTHVAR---------AQAGMYHCLAELPTGAAASA 1523
            P+   + +W  ++  +      ++  T  +               Y CL E   G     
Sbjct: 6955 PI---SVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDI-C 7010

Query: 1524 PVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPA 1583
              ++ VL PP     +  VE   G    L C+VD  P   ++ +     + S+       
Sbjct: 7011 EALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSA------- 7063

Query: 1584 EPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRA 1632
             P   +    N   + I  +  SD GEY C A N +G+ ++S    ++A
Sbjct: 7064 -PAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKA 7111



 Score =  168 bits (425), Expect = 5e-41
 Identities = 315/1464 (21%), Positives = 527/1464 (35%), Gaps = 241/1464 (16%)

Query: 94   EHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEG 153
            E+ V +  ++ +  +DSG Y F+ E    +   D    ++     P      + ++ + G
Sbjct: 5192 ENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLG 5251

Query: 154  TEVDFNCSTPYVCLQEQVRLQW--QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDH 211
            + +   C    V     +  QW   G++ + S  +     E +    +  L +    +D 
Sbjct: 5252 SSIHMECK---VSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLEL----EDT 5304

Query: 212  GRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAV 271
                    +VA   A S I L VK  P     L+ P  +  +P   V     +  + P  
Sbjct: 5305 ANYTCKVSNVAGDDACSGI-LTVKEPP---SFLVKPGRQQAIPDSTVEFKAILKGTPP-- 5358

Query: 272  SSIKWLKDGVR----------LQTKTGVLHLPQAAWSDAGVYTCQAENGVGS-------L 314
              IKW KD V           L+  T  L+L     S  G YTC   N VGS       L
Sbjct: 5359 FKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLL 5418

Query: 315  VSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH- 373
            V+ P     F+ +++ S    +    +  L C        ++R  W++N   L  +  + 
Sbjct: 5419 VTEPPK---FVKKLEASKI--VKAGDSSRLECKIAGS--PEIRVVWFRNEHELPASDKYR 5471

Query: 374  --------TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQA 425
                     ++++  +  D+G + CE QN  GS  S    V+V  PP+       +ET  
Sbjct: 5472 MTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGS-TSCSTKVIVKEPPVFSSFPPIVETLK 5530

Query: 426  GLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETD 485
                 L C +   P   +V       L S       S ++   S      + I +++ +D
Sbjct: 5531 NAEVSLECELSGTPPFEVVWYKDKRQLRS-------SKKYKIASKNFHTSIHILNVDTSD 5583

Query: 486  SGEYKCSATNSLGNATSTLDFHANAARLLISP--AAEVVEGQAVTLSCR-SGLSP----- 537
             GEY C A N +G+ T             +S   +  VV G+   L     G  P     
Sbjct: 5584 IGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQW 5643

Query: 538  ----------TPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPS 587
                      + + R ++  N A        +L    A   +AG Y C+ +  +      
Sbjct: 5644 LKEKEEVIRESENIRITFVENVA--------TLQFAKAEPANAGKYICQIK--NDGGMRE 5693

Query: 588  SPAVLTVLYPPRQPTFTTRLDLDAAG---AGAGRRGLLLCRVDSDPPARLQLLHKDRVVA 644
            + A L VL P         + ++ AG      G    L C+V   P   ++  +KD  + 
Sbjct: 5694 NMATLMVLEP--------AVIVEKAGPMTVTVGETCTLECKVAGTPELSVE-WYKDGKLL 5744

Query: 645  TSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATF 704
            TS             S + K +    +  + I +   ++ G Y  +  N +G +S +A  
Sbjct: 5745 TS-------------SQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVV 5791

Query: 705  NGQATVLAIAPSHTLQ---EGTEANLTCNVSREAAG-SPANFSWFRNGVLWAQGP----- 755
            +   +  A+ PS T +    G     +C +  + AG SP + +WF        G      
Sbjct: 5792 D--VSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTT 5849

Query: 756  ----LETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGH 811
                + T+ L  +  +D   Y C     AG+      +L+V  PP   K    L++  G 
Sbjct: 5850 FSDNVCTLQLNSLDSSDMGNYTCVAANVAGSD-ECRAVLTVQEPPSFVKEPEPLEVLPGK 5908

Query: 812  MALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDS 871
               F   +   P   +  F G   L            R     E    +LE+  + +  S
Sbjct: 5909 NVTFTSVIRGTPPFKVNWFRGARELVKG--------DRCNIYFEDTVAELELFNIDISQS 5960

Query: 872  GSYRCEATNVLG--SSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYR 929
            G Y C  +N  G  S  T LF +   A+++      ++ G++++L       +P   S  
Sbjct: 5961 GEYTCVVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLP--ISVT 6018

Query: 930  WYRDGQPLQES---------TSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHV 980
            W +DG  +  S          +  L     T   AG Y C+ +         A   +L  
Sbjct: 6019 WKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLE- 6077

Query: 981  SYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPR 1040
               P  VT    ++   G    L C+V   P   +    GD  +  T           P 
Sbjct: 6078 --PPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPT-----------PE 6124

Query: 1041 LHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVRE- 1099
                   N   L  +   + D G Y C+A N++G AS+   F  Q   +   P +  R+ 
Sbjct: 6125 YRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQL---PPSFARQL 6181

Query: 1100 -------GQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIP---LPNVT--------V 1141
                   G  V LTC +  + P Q+   WY+DG    D  ++    + NV         +
Sbjct: 6182 KDIEQTVGLPVTLTCRLNGSAPIQV--CWYRDGVLLRDDENLQTSFVDNVATLKILQTDL 6239

Query: 1142 RDATSYRCGVGPP-----------GRAPRLS-----RPITLDVLYAPRNLRLTYLLESHG 1185
              +  Y C    P            R P+ S     +P+++DV+                
Sbjct: 6240 SHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVI---------------A 6284

Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLL---ASSTAASVPNTLRLELRGPQPRDEGFYSCS 1242
            G+ A   C V    P ++  S   + +    + T   V NT  L +      D G Y+C 
Sbjct: 6285 GESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQ 6344

Query: 1243 ARSPLGQANTSLELRL-EGVRVILAPEAA--VPEGAPITVTCADPAAHAPTL-YTWYHNG 1298
            A + +G+   S +L + E  + +   EA+    +G  I + C    + +P +  +W+ N 
Sbjct: 6345 ATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLEC--KISGSPEIKVSWFRND 6402

Query: 1299 RWLQEGPAASLSFL---------VATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDA 1349
              L E    ++SF+          A+   +G Y C+A +  G  +S   AL V   P   
Sbjct: 6403 SELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGD-ASCSTALTVKAPPVFT 6461

Query: 1350 VLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNAL 1409
               S   +   S  ++QC +   PP E+    D K +  S         + H   + + L
Sbjct: 6462 QKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSK---KFKITSKHFDTSLHIL 6518

Query: 1410 RLQVQDVPAGDDTYVCTAQNLLGS 1433
             L+  DV      Y C A N +GS
Sbjct: 6519 NLEASDV----GEYHCKATNEVGS 6538



 Score =  164 bits (416), Expect = 5e-40
 Identities = 323/1488 (21%), Positives = 536/1488 (36%), Gaps = 223/1488 (14%)

Query: 258  VTLTCQVNSSYPAVSSIKWLKDGVRL----------QTKTGVLHLPQAAWSDAGVYTCQA 307
            +TL C V  + P +  +KWLKDG ++          +       +      D+G YT + 
Sbjct: 5158 MTLECVVAGT-PELK-VKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKV 5215

Query: 308  ENGVGSLVSPPISLHIFMAEVQVSPAGPILE-----NQTVTLVCNTPNEAPSDLRYSWYK 362
            EN  GS  S    L +    +  S    + +       ++ + C      P  +   W+K
Sbjct: 5216 ENDFGSS-SCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLP--ISAQWFK 5272

Query: 363  N---------HVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413
            +         + L+    S +L ++     DT  Y C+V NV G +    + + V  PP 
Sbjct: 5273 DGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGI-LTVKEPPS 5331

Query: 414  TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNS 473
              V       QA     +    + +      +      +   SG       F G  G  S
Sbjct: 5332 FLVKPG--RQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKC----FIGLEGSTS 5385

Query: 474  LRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISP--AAEVVE-GQAVTLS 530
              L +  ++ + +G+Y C  TN +G+ + T           +    A+++V+ G +  L 
Sbjct: 5386 F-LNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLE 5444

Query: 531  CRSGLSPTPDARFSWYLNGALLHEGPGSS------------LLLPAASSTDAGSYHCRAR 578
            C+  ++ +P+ R  W+ N    HE P S             + +   S+ D+G + C A+
Sbjct: 5445 CK--IAGSPEIRVVWFRNE---HELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQ 5499

Query: 579  DGHSASGPSSPAVLTVLYPPRQPTFTTRLD-LDAAGAGAGRRGLLLCRVDSDPPARLQLL 637
            +   ++  S+  +  V  PP   +F   ++ L  A         L C +   PP  + + 
Sbjct: 5500 NPAGSTSCSTKVI--VKEPPVFSSFPPIVETLKNAEVS------LECELSGTPPFEV-VW 5550

Query: 638  HKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGN 697
            +KD+    S             S + K+        + I N    + G Y C+A N +G+
Sbjct: 5551 YKDKRQLRS-------------SKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGS 5597

Query: 698  ASTSATFNGQATVLAIAP--SHTLQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGP 755
             +   T   +     ++   S T+  G  A L  ++       P    W +      +  
Sbjct: 5598 DTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIE---GAQPIFVQWLKEKEEVIRES 5654

Query: 756  -------LETVTLLPVARTD---AALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALL 805
                   +E V  L  A+ +   A  Y C+I  + G + +   L+ VL P    + +  +
Sbjct: 5655 ENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLM-VLEPAVIVEKAGPM 5713

Query: 806  DMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRE 865
             +  G      C V   P   +  +    LL +S   +   + +  +        L +  
Sbjct: 5714 TVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISS--------LRILS 5765

Query: 866  LGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE-----GQAVVLSCQVHT 920
            +   D+G+Y  +  N +G S+ +    V    V  S +  L+      G + +L C+V  
Sbjct: 5766 VERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAG 5825

Query: 921  GVPEGTSYRWYRD------GQPLQESTS---ATLRFAAITLTQAGAYHCQAQAPGSATTS 971
              P   S  W+ +      G   Q + S    TL+  ++  +  G Y C A     +   
Sbjct: 5826 SSP--ISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDEC 5883

Query: 972  LAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGV 1031
             A    L V   P  V     ++  PG+       +   PP ++    G R +       
Sbjct: 5884 RAV---LTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVK----- 5935

Query: 1032 GGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQ--AVNV 1089
                    R ++        LE+    +   G Y C  SN  GQAS +     +  A  +
Sbjct: 5936 ------GDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFL 5989

Query: 1090 QVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS-----------IPLPN 1138
            +     +V  G+ + L      T P  ++ TW +DG     +             + + N
Sbjct: 5990 KRLSDHSVEPGKSIILESTYTGTLP--ISVTWKKDGFNITTSEKCNIVTTEKTCILEILN 6047

Query: 1139 VTVRDATSYRCGV-GPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDS 1197
             T RDA  Y C +    GR    +   TL+  Y    L     LE+  G    + C V  
Sbjct: 6048 STKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEP---LEAAVGDSVSLQCQVAG 6104

Query: 1198 RPPAQLALSHAGRLLASSTAASV---PNTLRLELRGPQPRDEGFYSCSARSPLGQANTSL 1254
             P   ++       L  +         N   L        D G Y+C A + +G A++  
Sbjct: 6105 TPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKT 6164

Query: 1255 ELRLEG-------VRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGP-- 1305
              R++         R +   E  V  G P+T+TC    + AP    WY +G  L++    
Sbjct: 6165 VFRIQERQLPPSFARQLKDIEQTV--GLPVTLTCRLNGS-APIQVCWYRDGVLLRDDENL 6221

Query: 1306 -------AASLSFLVATRAHAGAYSCQAQDAQGTRSS--RPAALQVLYAPQDAVLSSFRD 1356
                    A+L  L    +H+G YSC A +  GT SS  R  A +   +P   +     D
Sbjct: 6222 QTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSID 6281

Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416
              A   A  +C V    P  +  S D K +           G   +    N   L++  V
Sbjct: 6282 VIAGESADFECHVTGAQPMRITWSKDNKEIRPG--------GNYTITCVGNTPHLRILKV 6333

Query: 1417 PAGDD-TYVCTAQNLLGSISTIGRLQV-EGARVVA--EPGLDVPEGAALNLSCRLLGGPG 1472
              GD   Y C A N +G      +L V E  + V   E      +G ++ L C++ G P 
Sbjct: 6334 GKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSP- 6392

Query: 1473 PVGNSTFAWFWNDRRLHAE---------PVPTLAFTHVARAQAGMYHCLAELPTGAAASA 1523
                   +WF ND  LH            V  L     +   +G Y C A    G A S 
Sbjct: 6393 ---EIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDA-SC 6448

Query: 1524 PVMLRVLYPPKTPTMMVFVE---PEGGLRG---ILDCRVDSEPLASLTLHLGSRLVASSQ 1577
               L V  PP      VF +   P G L+G   IL C +   P   +      + V +S+
Sbjct: 6449 STALTVKAPP------VFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSK 6502

Query: 1578 PQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTS 1625
                 ++   H   S + L      L  SD GEY C A+N +GS + S
Sbjct: 6503 KFKITSK---HFDTSLHILN-----LEASDVGEYHCKATNEVGSDTCS 6542



 Score =  161 bits (407), Expect = 6e-39
 Identities = 347/1631 (21%), Positives = 583/1631 (35%), Gaps = 258/1631 (15%)

Query: 135  VTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPT 194
            V E P       PVE+++ ++V+  C    V       + W   +  R +  +S+K+  T
Sbjct: 4951 VKEPPTFIRELKPVEVVKYSDVELECE---VTGTPPFEVTWLKNN--REIR-SSKKYTLT 5004

Query: 195  GVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILP 254
                +  LH+           +C +S           + +K  P  +K + + +   +L 
Sbjct: 5005 DRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTT--TVLK 5062

Query: 255  GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYT 304
                T    V  S P   SI WLKD   L     V          L +       +G YT
Sbjct: 5063 SS-ATFQSTVAGSPPI--SITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYT 5119

Query: 305  CQAENGVGS-------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVC---NTPNEAPS 354
            CQA+N  G        LV  P  +      V+ + +  + E   +TL C    TP     
Sbjct: 5120 CQAKNESGVERCYAFLLVQEPAQI------VEKAKSVDVTEKDPMTLECVVAGTP----- 5168

Query: 355  DLRYSWYKNHVLLEDAHSHTL---------RLHLATRADTGFYFCEVQNVHGSERSGPVS 405
            +L+  W K+   +  +   ++         R+    + D+G Y  +V+N  GS       
Sbjct: 5169 ELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYL 5228

Query: 406  VVVNH---PPLTPVLTAFLETQAGLVGILHCSVV-SEPLATLVLSHGGHILASTSGDSDH 461
             V++    P  T  LT  ++   G    + C V  S P++      G  I  S       
Sbjct: 5229 RVLDQNIPPSFTKKLTK-MDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSA------ 5281

Query: 462  SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGN-ATSTLDFHANAARLLISPAAE 520
              ++       S+ LE+ +LE  D+  Y C  +N  G+ A S +         L+ P  +
Sbjct: 5282 --KYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQ 5339

Query: 521  VVEGQAV---TLSCRSGLSPTPDARFSWYLNGALLHEGPG---------SSLLLPAASST 568
                QA+   T+  ++ L  TP  +  W+ +   L  GP          S L L +  ++
Sbjct: 5340 ----QAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDAS 5395

Query: 569  DAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDS 628
              G Y C     H  +   S +  T+L     P F  +L+       AG    L C++  
Sbjct: 5396 KTGQYTC-----HVTNDVGSDSCTTMLLVTEPPKFVKKLEASKI-VKAGDSSRLECKIAG 5449

Query: 629  DPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYL 688
             P  R+     +      LP+          S + ++T   ++  ++++N   E+ G ++
Sbjct: 5450 SPEIRVVWFRNEH----ELPA----------SDKYRMTFIDSVAVIQMNNLSTEDSGDFI 5495

Query: 689  CEASNALGNAS--TSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFR 746
            CEA N  G+ S  T           +  P     +  E +L C +S      P    W++
Sbjct: 5496 CEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELS---GTPPFEVVWYK 5552

Query: 747  NG---------VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPD 797
            +           + ++    ++ +L V  +D   Y C+   E G+   T V    L  P 
Sbjct: 5553 DKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSD--TCVCTVKLKEPP 5610

Query: 798  R--PKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAE 855
            R   KL++L  +      L      ++P+ +  L   E ++  S   ++           
Sbjct: 5611 RFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITF--------V 5662

Query: 856  ANSLKLEVRELGLGDSGSYRCEATNVLGS-SNTSLFFQVRGAWVQVSPSP-ELQEGQAVV 913
             N   L+  +    ++G Y C+  N  G   N +    +  A +     P  +  G+   
Sbjct: 5663 ENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCT 5722

Query: 914  LSCQVHTGVPEGTSYRWYRDGQPLQESTS---------ATLRFAAITLTQAGAYHCQAQA 964
            L C+V  G PE  S  WY+DG+ L  S           ++LR  ++    AG Y  Q Q 
Sbjct: 5723 LECKV-AGTPE-LSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQN 5780

Query: 965  PGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLG---LLLCRVDSDPPAQLRLLHGD 1021
                 +S  A + +     P   T   L +TG G LG   +L C+V    P  +   H  
Sbjct: 5781 -NVGKSSCTAVVDVSDRAVPPSFT-RRLKNTG-GVLGASCILECKVAGSSPISVAWFHEK 5837

Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081
              + S             +     + N   L+++     D G Y C A+N  G     A 
Sbjct: 5838 TKIVS-----------GAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAV 5886

Query: 1082 FDAQAVNVQVWPGATVRE--------GQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH- 1132
               Q       P + V+E        G+ V  T ++  T P ++   W++  ++ +    
Sbjct: 5887 LTVQE------PPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVN--WFRGARELVKGDR 5938

Query: 1133 ----------SIPLPNVTVRDATSYRCGVGP-PGRAPRLSRPITLDVLYAPRNLRLTYLL 1181
                       + L N+ +  +  Y C V    G+A   +R      L+          L
Sbjct: 5939 CNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTR------LFVKEPAAFLKRL 5992

Query: 1182 ESHG---GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLR---LELRGPQPRD 1235
              H    G+  ++  T     P  +     G  + +S   ++  T +   LE+     RD
Sbjct: 5993 SDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRD 6052

Query: 1236 EGFYSCSARSPLGQ-ANTSLELRLEGVRVI--LAP-EAAVPEGAPITVTCADPAAHAPTL 1291
             G YSC   +  G+    +L   LE    +  L P EAAV  G  +++ C        T+
Sbjct: 6053 AGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAV--GDSVSLQCQVAGTPEITV 6110

Query: 1292 YTWYHNGRWLQEGP---------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPA-ALQ 1341
             +WY     L+  P          A+L F       +G Y+C+A+++ GT SS+    +Q
Sbjct: 6111 -SWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQ 6169

Query: 1342 VLYAPQDAVLSSFRDSRARSMAV-IQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTG 1400
                P           +   + V + C ++   P ++    DG +L     +      T 
Sbjct: 6170 ERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQ-----TS 6224

Query: 1401 HVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARV-----VAEPGLDV 1455
             V        LQ     +G   Y C+A N LG+ S+  RL     +      +    +DV
Sbjct: 6225 FVDNVATLKILQTDLSHSGQ--YSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDV 6282

Query: 1456 PEGAALNLSCRLLGGPG-------------PVGNSTFAWFWNDRRLHAEPVPTLAFTHVA 1502
              G + +  C + G                P GN T     N         P L    V 
Sbjct: 6283 IAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGN--------TPHLRILKVG 6334

Query: 1503 RAQAGMYHCLAELPTGAAASAPVMLRVLYPPK-TPTMMVFVEPEGGLRGILDCRVDSEPL 1561
            +  +G Y C A    G    +   L V  PPK    +      + G    L+C++   P 
Sbjct: 6335 KGDSGQYTCQATNDVGKDMCS-AQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPE 6393

Query: 1562 ASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621
              ++       +  S          + +L         I      D G+YIC A N +G 
Sbjct: 6394 IKVSWFRNDSELHESWKYNMSFINSVALLT--------INEASAEDSGDYICEAHNGVGD 6445

Query: 1622 ASTSTYFGVRA 1632
            AS ST   V+A
Sbjct: 6446 ASCSTALTVKA 6456



 Score =  158 bits (400), Expect = 4e-38
 Identities = 348/1716 (20%), Positives = 599/1716 (34%), Gaps = 260/1716 (15%)

Query: 53   DGITAIWYYDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGS 112
            D + A WY D                +E  F+ +       E R+  + + + +  D+G 
Sbjct: 3173 DDVDAHWYKDG---------------IEINFQVQERHKYVVERRIHRMFISETRQSDAGE 3217

Query: 113  YNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVR 172
            Y F   ++  NR S      V   E P+V     PV +  G    F C+   +  + Q +
Sbjct: 3218 YTF---VAGRNRSSVT--LYVNAPEPPQVLQELQPVTVQSGKPARF-CAV--ISGRPQPK 3269

Query: 173  LQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQ----LSVANHRAQS 228
            + W  ++   S  F  +       G   TL +  ++ +   +  C+      VA   A  
Sbjct: 3270 ISWYKEEQLLSTGFKCKFLHD---GQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASL 3326

Query: 229  EIHLQVKYAPKGVKILLSPSGRNIL------PGELVTLTCQVNSSYPAVSSIKWLKDGVR 282
             + +    +P     +  P+    L       G+     C+V+ +   VS   W     +
Sbjct: 3327 SVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVS---WYSKDKK 3383

Query: 283  LQTK----------TGVLHLPQAAWSDAGVYTCQAENGVG--------SLVSPPISLH-I 323
            ++            T  L + +A   D G YT  A N VG        SL +P   LH  
Sbjct: 3384 IKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHER 3443

Query: 324  FMAEVQVS-PAGPILENQTVTL----------VCNTPNEAPSDLRYSWYKNHVLLEDAHS 372
               E+++   A P+++ +   L           C    ++  ++R+ W+K    + ++  
Sbjct: 3444 IEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEI--QSAPNVRFQWFKAGREIYESDK 3501

Query: 373  HTLRLH--------LATR-ADTGFYFCEVQNVHGS-ERSGPVSVVVNHPPLTPVLTAFLE 422
             ++R          L T+  D G Y C+  N +GS   +  ++V   +PP        L 
Sbjct: 3502 CSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLT 3561

Query: 423  TQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLE 482
            T  G      C+V   P+   +    G  L+        SP +  +   N   LE+ +L 
Sbjct: 3562 TFVGKAAKFICTVTGTPVIETIWQKDGAALSP-------SPNWRISDAENKHILELSNLT 3614

Query: 483  ETDSGEYKCSATNSLG--------------NATSTLDFHANAARLLISPAAEVVEGQAVT 528
              D G Y C A+N  G              +    L+   +A    +    +V E + VT
Sbjct: 3615 IQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINKKVHLECQVDEDRKVT 3674

Query: 529  LSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSS 588
            ++        P  +     +  +  E   ++L +P A   D+G+Y C A   + A   S 
Sbjct: 3675 VTWSKDGQKLPPGK-----DYKICFEDKIATLEIPLAKLKDSGTYVCTA--SNEAGSSSC 3727

Query: 589  PAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLP 648
             A +TV  P   P+F  ++D        G    L C++   P  ++     ++ ++ S  
Sbjct: 3728 SATVTVREP---PSFVKKVDPSYLML-PGESARLHCKLKGSPVIQVTWFKNNKELSES-- 3781

Query: 649  SGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG--NASTSATFNG 706
                       + RM    +  +L  +I +  +E+ G Y CEA N +G  + ST      
Sbjct: 3782 ----------NTVRMYFVNSEAIL--DITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKE 3829

Query: 707  QATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLE 757
              + +       +  GT A L C VS      P   SWF++           L++Q  L 
Sbjct: 3830 PPSFIKTLEPADIVRGTNALLQCEVS---GTGPFEISWFKDKKQIRSSKKYRLFSQKSLV 3886

Query: 758  TVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFIC 817
             + +      D   Y C +  E G        L    P    K+  L+ +G   + L   
Sbjct: 3887 CLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAA 3946

Query: 818  TVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCE 877
               S P++ +    G+ +        +   G+ +         L + ++ +   G Y C 
Sbjct: 3947 VRGSEPIS-VTWMKGQEV--------IREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCL 3997

Query: 878  ATNVLGSSNT--SLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQ 935
            A N  GS  +   L  +     ++ +   ++  G    L   V  G PE    +WY+DG+
Sbjct: 3998 AENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTV-AGTPE-LKPKWYKDGR 4055

Query: 936  PLQESTS---------ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRH 986
            PL  S           A L+F +  L  +G Y  +      +++       L    AP  
Sbjct: 4056 PLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFF 4115

Query: 987  VTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVA 1046
                  +D+       L C++    P ++      + +A           +S R  +A  
Sbjct: 4116 TKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIA-----------ASDRYRIAFV 4164

Query: 1047 PNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNL- 1105
              T  LEI    + D G + C A+N++G   +S      A+ VQ  P    + G    L 
Sbjct: 4165 EGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSG-----ALIVQEPPSFVTKPGSKDVLP 4219

Query: 1106 ---TCLVWTTH-PAQLTYTWYQDGQQRLDA-----------HSIPLPNVTVRDATSYRCG 1150
                CL  T      LT  W++  ++ +              S+ L  V   D+ +Y C 
Sbjct: 4220 GSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCK 4279

Query: 1151 VGPPGRAPRLSRPITL-DVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAG 1209
            V         S  + + +       L  + LL+   G    + C V   PP ++      
Sbjct: 4280 VSNVAGGVECSANLFVKEPATFVEKLEPSQLLKK--GDATQLACKVTGTPPIKITWFAND 4337

Query: 1210 RLLASST---AASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILA 1266
            R +  S+    + V +T  L L      D G Y C A++  G  + S       + ++  
Sbjct: 4338 REIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCS------SIVIVKE 4391

Query: 1267 PEAAVPEGAPITV-------TCADPAAHAPTLYTWYHNGRWLQEG---------PAASLS 1310
                  E  PI V         A+ A   P   TW+ +   L+ G            SL 
Sbjct: 4392 SPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQ 4451

Query: 1311 FLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR-SMAVIQCTV 1369
             L    A AG Y C+  +  G  SS  +A   L  P   +      S  R   A  Q T+
Sbjct: 4452 ILKFVAADAGEYQCRVTNEVG--SSICSARVTLREPPSFIKKIESTSSLRGGTAAFQATL 4509

Query: 1370 DSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPA-GDDTYVCTAQ 1428
                P  +    D   +     +         +    N   L +  +    D  YVC A+
Sbjct: 4510 KGSLPITVTWLKDSDEITEDDNI--------RMTFENNVASLYLSGIEVKHDGKYVCQAK 4561

Query: 1429 NLLGSISTIGRLQVEGARVVAEP--GLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDR 1486
            N  G       L V+    + E    +DV +G    L  +  G        T  WF + +
Sbjct: 4562 NDAGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSG----TKEITAKWFKDGQ 4617

Query: 1487 RLH---------AEPVPTLAFTHVARAQAGMYHCLAELPTG-AAASAPV-MLRVLYPPKT 1535
             L           + V  L      +  +G Y    +   G ++  A + +L ++ PP  
Sbjct: 4618 ELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSF 4677

Query: 1536 PTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNA 1595
               +  ++   G    L+C V      S+      + +++S+                N 
Sbjct: 4678 TKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASE--------KYKFSFHDNT 4729

Query: 1596 LRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
              ++I  L  +D G Y CSA+N  G    S +  V+
Sbjct: 4730 AFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVK 4765



 Score =  157 bits (396), Expect = 1e-37
 Identities = 328/1640 (20%), Positives = 590/1640 (35%), Gaps = 234/1640 (14%)

Query: 100  LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159
            L L D+  EDSG Y      ++    SD   ++V V E P       P+E+L+  +V   
Sbjct: 4357 LRLTDVGIEDSGEYMCE---AQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLL 4413

Query: 160  CSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQL 219
                 V       + W   +   ++  + +K++     HL +L +           +C++
Sbjct: 4414 AE---VAGTPPFEITWFKDN---TILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRV 4467

Query: 220  SVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKD 279
            +     +     + ++  P  +K + S S    L G        +  S P   ++ WLKD
Sbjct: 4468 TNEVGSSICSARVTLREPPSFIKKIESTSS---LRGGTAAFQATLKGSLPI--TVTWLKD 4522

Query: 280  G--------VRLQTKTGV--LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQ 329
                     +R+  +  V  L+L        G Y CQA+N  G        +    A + 
Sbjct: 4523 SDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAG--------IQRCSALLS 4574

Query: 330  VSPAGPILENQTVTLVCNTPNEAPSDLRYS--------WYKN----------HVLLEDAH 371
            V     I E + V++     + A   +++S        W+K+           + + D  
Sbjct: 4575 VKEPATITE-EAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTDTV 4633

Query: 372  SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGI- 430
            S  L++    + D+G Y  EVQN  G   S    + V    + P  T  L+    + G  
Sbjct: 4634 S-ILKIISTEKKDSGEYTFEVQNDVGRS-SCKARINVLDLIIPPSFTKKLKKMDSIKGSF 4691

Query: 431  --LHCSVV-SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
              L C V  S P++         I AS         ++  +   N+  LEI  LE TDSG
Sbjct: 4692 IDLECIVAGSHPISIQWFKDDQEISASE--------KYKFSFHDNTAFLEISQLEGTDSG 4743

Query: 488  EYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYL 547
             Y CSATN  G+   +           +             +  ++ +  T      W+ 
Sbjct: 4744 TYTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFK 4803

Query: 548  NGALLHEG---------PGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
            +   LH G           +SL L AA +TD+G+Y C+    +     +S A L V  PP
Sbjct: 4804 DNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQL--SNDVGTATSKATLFVKEPP 4861

Query: 599  R-----QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGC 653
            +      P    R          G+     C++   P  R+   + D    T++   G  
Sbjct: 4862 QFIKKPSPVLVLR---------NGQSTTFECQITGTPKIRVS-WYLDGNEITAIQKHG-- 4909

Query: 654  STCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAI 713
                       ++    L   +I    +E  G Y+CEA N  G AS S     +     I
Sbjct: 4910 -----------ISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFI 4958

Query: 714  APSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVT---------LL 762
                 ++  + ++  L C V+      P   +W +N          T+T         + 
Sbjct: 4959 RELKPVEVVKYSDVELECEVT---GTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHIT 5015

Query: 763  PVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSR 822
                +D   Y C I++  G   S    +++  PP   K            A F  TV   
Sbjct: 5016 KCDPSDTGEYQC-IVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGS 5074

Query: 823  PLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVL 882
            P   +     + +L                    +   L++R +  G SG Y C+A N  
Sbjct: 5075 PPISITWLKDDQIL--------DEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNES 5126

Query: 883  GSSNTSLFFQVR--GAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQ-- 938
            G      F  V+     V+ + S ++ E   + L C V  G PE    +W +DG+ +   
Sbjct: 5127 GVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVV-AGTPE-LKVKWLKDGKQIVPS 5184

Query: 939  -------ESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTT 991
                   E+  A+ R  ++    +G Y  + +    +++  A    L  +  P      T
Sbjct: 5185 RYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLT 5244

Query: 992  LMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLR 1051
             MD   G    + C+V    P   +     + ++           +S +  +     ++ 
Sbjct: 5245 KMDKVLGSSIHMECKVSGSLPISAQWFKDGKEIS-----------TSAKYRLVCHERSVS 5293

Query: 1052 LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQ-------LVN 1104
            LE++   LED   Y C+ SN  G  + S       + V+  P   V+ G+        V 
Sbjct: 5294 LEVNNLELEDTANYTCKVSNVAGDDACSG-----ILTVKEPPSFLVKPGRQQAIPDSTVE 5348

Query: 1105 LTCLVWTTHPAQLTYTWYQDGQQRLDAHS-----------IPLPNVTVRDATSYRCGV-G 1152
               ++  T P ++   W++D  + +               + L +V       Y C V  
Sbjct: 5349 FKAILKGTPPFKI--KWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTN 5406

Query: 1153 PPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLL 1212
              G     +  +  +     + L  + ++++  G  + + C +   P  ++        L
Sbjct: 5407 DVGSDSCTTMLLVTEPPKFVKKLEASKIVKA--GDSSRLECKIAGSPEIRVVWFRNEHEL 5464

Query: 1213 ASS---TAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVI--LAP 1267
             +S       + +   +++      D G + C A++P G  + S ++ ++   V     P
Sbjct: 5465 PASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPP 5524

Query: 1268 EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPA---------ASLSFLVATRAH 1318
                 + A +++ C + +   P    WY + R L+              S+  L    + 
Sbjct: 5525 IVETLKNAEVSLEC-ELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSD 5583

Query: 1319 AGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELA 1378
             G Y C+AQ+  G+  +    +++   P+     +     A   A +Q +++   P  + 
Sbjct: 5584 IGEYHCKAQNEVGS-DTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQ 5642

Query: 1379 -LSHDGKVLATSSGVHSLASGTGHVQVARNALRLQ-VQDVPAGDDTYVCTAQNLLGSIST 1436
             L    +V+  S  +         +    N   LQ  +  PA    Y+C  +N  G    
Sbjct: 5643 WLKEKEEVIRESENI--------RITFVENVATLQFAKAEPANAGKYICQIKNDGGMREN 5694

Query: 1437 IGRLQV-EGARVVAEPG-LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA---- 1490
            +  L V E A +V + G + V  G    L C++ G P      +  W+ + + L +    
Sbjct: 5695 MATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTP----ELSVEWYKDGKLLTSSQKH 5750

Query: 1491 -----EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPE 1545
                   + +L    V R  AG Y    +   G  +S   ++ V      P+    ++  
Sbjct: 5751 KFSFYNKISSLRILSVERQDAGTYTFQVQNNVG-KSSCTAVVDVSDRAVPPSFTRRLKNT 5809

Query: 1546 GGLRG---ILDCRV-DSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIE 1601
            GG+ G   IL+C+V  S P++    H  +++V+ ++ Q            S N   + + 
Sbjct: 5810 GGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQ---------TTFSDNVCTLQLN 5860

Query: 1602 ALRPSDQGEYICSASNVLGS 1621
            +L  SD G Y C A+NV GS
Sbjct: 5861 SLDSSDMGNYTCVAANVAGS 5880



 Score =  150 bits (380), Expect = 8e-36
 Identities = 314/1497 (20%), Positives = 525/1497 (35%), Gaps = 247/1497 (16%)

Query: 253  LPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTK----------TGVLHLPQAAWSDAGV 302
            + G  + L C V  S+P   SI+W KD   +             T  L + Q   +D+G 
Sbjct: 4687 IKGSFIDLECIVAGSHPI--SIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGT 4744

Query: 303  YTCQAENGVG--------SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPS 354
            YTC A N  G        ++  PP     F+ + Q     P    Q   LV  T   AP 
Sbjct: 4745 YTCSATNKAGHNQCSGHLTVKEPPY----FVEKPQSQDVNPNTRVQLKALVGGT---APM 4797

Query: 355  DLRYSWYKNHVLL---------EDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVS 405
             ++  W+K++  L         +D  S +L L  A   D+G Y C++ N  G+  S    
Sbjct: 4798 TIK--WFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATL 4855

Query: 406  VVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRF 465
             V   P      +  L  + G      C +   P   +     G+ + +           
Sbjct: 4856 FVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKH------- 4908

Query: 466  SGTSGPNSLR-LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA--AEVV 522
             G S  + L   +I      +SG Y C A N  G A+ +++         I      EVV
Sbjct: 4909 -GISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRELKPVEVV 4967

Query: 523  EGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLL---------LPAASSTDAGSY 573
            +   V L C   ++ TP    +W  N   +      +L          +     +D G Y
Sbjct: 4968 KYSDVELECE--VTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEY 5025

Query: 574  HCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPAR 633
             C   +     G  S +    L  P  P+F  +++       +         V   PP  
Sbjct: 5026 QCIVSN---EGGSCSCSTRVALKEP--PSFIKKIENTTTVLKSS--ATFQSTVAGSPPIS 5078

Query: 634  LQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASN 693
            +  L  D+++                   + ++   ++  ++I +      G Y C+A N
Sbjct: 5079 ITWLKDDQILDED--------------DNVYISFVDSVATLQIRSVDNGHSGRYTCQAKN 5124

Query: 694  ALGNASTSATFNGQ--ATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNGV- 749
              G     A    Q  A ++  A S  + E     L C V    AG+P     W ++G  
Sbjct: 5125 ESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVV----AGTPELKVKWLKDGKQ 5180

Query: 750  --------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVL---YPPDR 798
                    +  +  + +  +  V + D+  Y  ++  + G+  S    L VL    PP  
Sbjct: 5181 IVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSS-SCDAYLRVLDQNIPPSF 5239

Query: 799  PKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANS 858
             K    +D   G      C V S  L + A +  +       G ++ +  +++      S
Sbjct: 5240 TKKLTKMDKVLGSSIHMECKV-SGSLPISAQWFKD-------GKEISTSAKYRLVCHERS 5291

Query: 859  LKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEG--QAVVLSC 916
            + LEV  L L D+ +Y C+ +NV G    S    V+       PS  ++ G  QA+  S 
Sbjct: 5292 VSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVK-----EPPSFLVKPGRQQAIPDST 5346

Query: 917  QVHTGVPEGT---SYRWYRDGQPL---------QESTSATLRFAAITLTQAGAYHCQAQ- 963
                 + +GT     +W++D   L          E +++ L   ++  ++ G Y C    
Sbjct: 5347 VEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTN 5406

Query: 964  --APGSATTSLAAPISLHVSYAPRHV-TLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020
                 S TT L       V+  P+ V  L        G    L C++   P  ++     
Sbjct: 5407 DVGSDSCTTMLL------VTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRN 5460

Query: 1021 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080
            +  +            +S +  +    +   ++++    ED G +ICEA N  G  S S 
Sbjct: 5461 EHELP-----------ASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCST 5509

Query: 1081 DFDAQAVNV--QVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH------ 1132
                +   V     P     +   V+L C +  T P ++   WY+D +Q   +       
Sbjct: 5510 KVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEV--VWYKDKRQLRSSKKYKIAS 5567

Query: 1133 -----SIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQ 1187
                 SI + NV   D   Y C           +   T+ +   PR +     L    G+
Sbjct: 5568 KNFHTSIHILNVDTSDIGEYHCKA--QNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGE 5625

Query: 1188 LALVLCTVDSRPPAQLA-LSHAGRLLASS---TAASVPNTLRLELRGPQPRDEGFYSCSA 1243
             A +  +++   P  +  L     ++  S       V N   L+    +P + G Y C  
Sbjct: 5626 PAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQI 5685

Query: 1244 RSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCAD------PAAHAPTL-YTWYH 1296
            ++  G       L      ++L P   V +  P+TVT  +        A  P L   WY 
Sbjct: 5686 KNDGGMRENMATL------MVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYK 5739

Query: 1297 NGRWLQE---------GPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQ 1347
            +G+ L              +SL  L   R  AG Y+ Q Q+  G +SS  A + V     
Sbjct: 5740 DGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVG-KSSCTAVVDV---SD 5795

Query: 1348 DAVLSSFRDSRAR------SMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGH 1401
             AV  SF            +  +++C V    P  +A  H+   + + +   +  S    
Sbjct: 5796 RAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSD--- 5852

Query: 1402 VQVARNALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQV-EGARVVAEP-GLDVPEG 1458
                 N   LQ+  + + D   Y C A N+ GS      L V E    V EP  L+V  G
Sbjct: 5853 -----NVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPG 5907

Query: 1459 AALNLSCRLLGGPGPVGNSTFAWFWNDRRL---------HAEPVPTLAFTHVARAQAGMY 1509
              +  +  + G P    N    WF   R L           + V  L   ++  +Q+G Y
Sbjct: 5908 KNVTFTSVIRGTPPFKVN----WFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEY 5963

Query: 1510 HCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTL--- 1566
             C+     G A+               T +   EP   L+ + D  V  EP  S+ L   
Sbjct: 5964 TCVVSNNAGQASCT-------------TRLFVKEPAAFLKRLSDHSV--EPGKSIILEST 6008

Query: 1567 HLGSRLVASSQPQ---GAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620
            + G+  ++ +  +           +++ +     ++I      D G+Y C   N  G
Sbjct: 6009 YTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAG 6065



 Score =  140 bits (353), Expect = 1e-32
 Identities = 293/1321 (22%), Positives = 474/1321 (35%), Gaps = 211/1321 (15%)

Query: 135  VTEEPRVPTIASPVELLEGTEVDFNCSTPYVCL---QEQVRLQWQGQDPARSVTFNSQKF 191
            V E PR      P  +++  E      T Y C      ++++ W   +        S KF
Sbjct: 7301 VQEPPRFIKKLEPSRIVKQDEF-----TRYECKIGGSPEIKVLWYKDETEIQ---ESSKF 7352

Query: 192  EPTGVGHLETLHMA-MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGR 250
              + V  +  L M  +S +D G    C+   A   A S   L+VK  P   K    P   
Sbjct: 7353 RMSFVDSVAVLEMHNLSVEDSGDYT-CEAHNAAGSASSSTSLKVKEPPIFRK---KPHPI 7408

Query: 251  NILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDA 300
              L G  V L C++  + P    + W KD   L++              +H+     +D 
Sbjct: 7409 ETLKGADVHLECELQGTPPF--HVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADI 7466

Query: 301  GVYTCQAENGVGS--------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEA 352
            G Y C+A N VGS        L +PP  +       ++S    ++  +   +   T  E 
Sbjct: 7467 GEYQCKATNDVGSDTCVGSIALKAPPRFVK------KLSDISTVVGKE---VQLQTTIEG 7517

Query: 353  PSDLRYSWYK----------NHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSG 402
               +   W+K          N  +    +  TL+      A+ G Y C+++N  G +   
Sbjct: 7518 AEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECF 7577

Query: 403  PVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEP-LATLVLSHGGHILASTSGDSDH 461
              ++ V  P         ++   G    L C+V   P L+T     G  +   TS +   
Sbjct: 7578 -ATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKEL---TSDNKYK 7633

Query: 462  SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEV 521
               F+  SG     L+I ++  +DSG Y     N +G  + T     +   +  S   ++
Sbjct: 7634 ISFFNKVSG-----LKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKL 7688

Query: 522  VE-----GQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPG---------SSLLLPAASS 567
             E     G +V + C+  +  +P    SW+  G  +  G            +L +     
Sbjct: 7689 KETNGLSGSSVVMECK--VYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEE 7746

Query: 568  TDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLD-LDAAGAGAGRRGLLLCRV 626
            +D+G Y C A +   +   S+P  LTV  PP   +F  + D +D      G        V
Sbjct: 7747 SDSGDYTCIATNMAGSDECSAP--LTVREPP---SFVQKPDPMDVL---TGTNVTFTSIV 7798

Query: 627  DSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGL 686
               PP  +         ++ L  G  C+          V+   ++  +E+ +    + G 
Sbjct: 7799 KGTPPFSVSWFKG----SSELVPGDRCN----------VSLEDSVAELELFDVDTSQSGE 7844

Query: 687  YLCEASNALGNAS--TSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSW 744
            Y C  SN  G AS  T       A  +     +++++G    L    +      P + +W
Sbjct: 7845 YTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFT---GTPPISVTW 7901

Query: 745  FRNGVLWAQGPLETVT------LLPVART---DAALYACRILTEAGAQLSTPVLLSVLYP 795
             +NG+         +T      +L +  +   DA  Y C I   +G    +  +L +L P
Sbjct: 7902 KKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQIL-ILEP 7960

Query: 796  PDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAE 855
            P   K    + +  G  A   C +   P   ++ + G+    T L P       F+    
Sbjct: 7961 PYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGD----TKLRPTTTYKMHFRN--- 8013

Query: 856  ANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE-----GQ 910
             N   L   ++ + DSG Y C+A N +G  + S F  V+   +  S S +L++     G 
Sbjct: 8014 -NVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGL 8072

Query: 911  AVVLSCQVHTGVPEGTSYRWYRDGQPLQES---------TSATLRFAAITLTQAGAYHCQ 961
             VV  C +    P   S  WY+DG+PL++S          +ATL       + AG Y C 
Sbjct: 8073 PVVFDCAISGSEPISVS--WYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCT 8130

Query: 962  AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGD 1021
            A  P  + +S A  I       P        +D   G      C V    P ++      
Sbjct: 8131 ATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDS 8190

Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081
            R + S     GG      +  ++   N+  L +      D G Y C A N +G+ S +A 
Sbjct: 8191 REIRS-----GG------KYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQ 8239

Query: 1082 FDAQAVNVQVWPGATVR--------EGQLVNLTCLVWTTHPAQLTYTWYQDGQ--QRLDA 1131
             + +   +   P  T R        EG    L   V  + P  +T  WY++    Q    
Sbjct: 8240 LNIKERLIP--PSFTKRLSETVEETEGNSFKLEGRVAGSQP--ITVAWYKNNIEIQPTSN 8295

Query: 1132 HSIPLPNVTV---------RDATSYRCGVGPPGRAPRLSRPITLDVLYAPR--NLRLTYL 1180
              I   N T+          DA  Y C V     +   +  I +     P   +  LT +
Sbjct: 8296 CEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPV 8355

Query: 1181 LESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAAS---VPNTLRLELRGPQPRDEG 1237
              S G  + L  C V    P ++    AGR +  S   S      T  LELR     D G
Sbjct: 8356 TVSEGEYVQLS-CHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSG 8414

Query: 1238 FYSCSARSPLGQANTSLELRLEGVRVILAP---EAAV---------PEGAPI----TVTC 1281
             Y C A +  G   T  ++ ++  +  +AP   +AAV         P+   +    T T 
Sbjct: 8415 DYVCKASNVAGSDTTKSKVTIKD-KPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATF 8473

Query: 1282 ADPAAHAPTLYTWYHNGRWL-----------QEGPAASLSFLVATRAHAGAYSCQAQDAQ 1330
                   P     +  G+W            Q+G  A L     T+  +G Y C A +  
Sbjct: 8474 IAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEH 8533

Query: 1331 G 1331
            G
Sbjct: 8534 G 8534



 Score =  119 bits (297), Expect = 3e-26
 Identities = 188/853 (22%), Positives = 310/853 (36%), Gaps = 121/853 (14%)

Query: 95   HRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTV-TEEPRVPTIASPVELLEG 153
            ++V  L + ++ P DSG Y+F  + + V + S      V+  T  P           L G
Sbjct: 7638 NKVSGLKIINVAPSDSGVYSFEVQ-NPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSG 7696

Query: 154  TEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGR 213
            + V   C    V     + + W  +    S   + +K++ T   +   L + M  +    
Sbjct: 7697 SSVVMECK---VYGSPPISVSWFHEGNEIS---SGRKYQTTLTDNTCALTVNMLEESDSG 7750

Query: 214  ILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSS 273
               C  +      +    L V+  P  V+    P   ++L G  VT T  V  + P   S
Sbjct: 7751 DYTCIATNMAGSDECSAPLTVREPPSFVQ---KPDPMDVLTGTNVTFTSIVKGTPPF--S 7805

Query: 274  IKWLKDG----------VRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSL-------VS 316
            + W K            V L+     L L     S +G YTC   N  G         + 
Sbjct: 7806 VSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIK 7865

Query: 317  PPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH----- 371
             P      + +  +    P++   T T    TP      +  +W KN + +  +      
Sbjct: 7866 APAKFVKRLNDYSIEKGKPLILEGTFT---GTP-----PISVTWKKNGINVTPSQRCNIT 7917

Query: 372  ----SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGL 427
                S  L +  +T  D G Y C ++N  G + S    +++  PP        ++   G 
Sbjct: 7918 TTEKSAILEIPSSTVEDAGQYNCYIENASGKD-SCSAQILILEPPYFVKQLEPVKVSVGD 7976

Query: 428  VGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
               L C +   P   +    G   L  T+    H          N   L    ++  DSG
Sbjct: 7977 SASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRN-------NVATLVFNQVDINDSG 8029

Query: 488  EYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE-----GQAVTLSCRSGLSPTPDAR 542
            EY C A NS+G  +++        +L  S + ++ +     G  V   C   +S +    
Sbjct: 8030 EYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDC--AISGSEPIS 8087

Query: 543  FSWYLNGALLHEGPG--SSLLLPAAS----STD---AGSYHCRARDGHSASGPSSPAVLT 593
             SWY +G  L + P   +S L   A+     TD   AG Y C A +   ++  S+  +LT
Sbjct: 8088 VSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILT 8147

Query: 594  VLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGC 653
                P  P F  RL      A  G      C V    P ++      R +     SGG  
Sbjct: 8148 EGKNP--PFFDIRLA--PVDAVVGESADFECHVTGTQPIKVSWAKDSREIR----SGG-- 8197

Query: 654  STCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAI 713
                    + +++   N   + +      + G Y C A N +G  S +A  N +  +  I
Sbjct: 8198 --------KYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERL--I 8247

Query: 714  APSHTLQ-----EGTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLETV 759
             PS T +     E TE N      R A   P   +W++N +         +  +     +
Sbjct: 8248 PPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVL 8307

Query: 760  TLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLS----ALLDMGQGHMALF 815
             +      DA LY C++  +AG+ L T  +  V+  P +P +       + + +G     
Sbjct: 8308 QVRKAGMNDAGLYTCKVSNDAGSALCTSSI--VIKEPKKPPVFDQHLTPVTVSEGEYVQL 8365

Query: 816  ICTVD-SRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSY 874
             C V  S P+ +  L           G ++    R      + +  LE+R++   DSG Y
Sbjct: 8366 SCHVQGSEPIRIQWL---------KAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDY 8416

Query: 875  RCEATNVLGSSNT 887
             C+A+NV GS  T
Sbjct: 8417 VCKASNVAGSDTT 8429



 Score =  119 bits (297), Expect = 3e-26
 Identities = 213/928 (22%), Positives = 345/928 (37%), Gaps = 162/928 (17%)

Query: 251  NILPGELVTLTCQVNSSYPAVSSIKWLKDG----------VRLQTKTGVLHLPQAAWSDA 300
            N L G  V + C+V  S P   S+ W  +G            L   T  L +     SD+
Sbjct: 7692 NGLSGSSVVMECKVYGSPPI--SVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDS 7749

Query: 301  GVYTCQAENGVGS-LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYS 359
            G YTC A N  GS   S P+++    + VQ      +L    VT         P  +  S
Sbjct: 7750 GDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSV--S 7807

Query: 360  WYKN----------HVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVN 409
            W+K           +V LED+ +  L L     + +G Y C V N  G + S    + + 
Sbjct: 7808 WFKGSSELVPGDRCNVSLEDSVAE-LELFDVDTSQSGEYTCIVSNEAG-KASCTTHLYIK 7865

Query: 410  HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTS 469
             P            + G   IL  +    P  ++     G  +         S R + T+
Sbjct: 7866 APAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTP-------SQRCNITT 7918

Query: 470  GPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA--------AEV 521
               S  LEI      D+G+Y C   N+ G  +       +A  L++ P          +V
Sbjct: 7919 TEKSAILEIPSSTVEDAGQYNCYIENASGKDS------CSAQILILEPPYFVKQLEPVKV 7972

Query: 522  VEGQAVTLSCRSGLSPTPDARFSWYLNGALLH---------EGPGSSLLLPAASSTDAGS 572
              G + +L C+  L+ TP+   SWY     L              ++L+       D+G 
Sbjct: 7973 SVGDSASLQCQ--LAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGE 8030

Query: 573  YHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRL-DLDAAGAGAGRRGLLLCRVDSDPP 631
            Y C+A +  S    S+   LTV      P+F+ +L D+       G   +  C +    P
Sbjct: 8031 YICKAEN--SVGEVSASTFLTVQEQKLPPSFSRQLRDVQET---VGLPVVFDCAISGSEP 8085

Query: 632  ARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEA 691
              +      + +  S              P ++ +   N   + I        G Y C A
Sbjct: 8086 ISVSWYKDGKPLKDS--------------PNVQTSFLDNTATLNIFKTDRSLAGQYSCTA 8131

Query: 692  SNALGNASTSATF------NGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSW- 744
            +N +G+AS+SA        N     + +AP   +  G  A+  C+V+      P   SW 
Sbjct: 8132 TNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVV-GESADFECHVT---GTQPIKVSWA 8187

Query: 745  -----FRNGVLWAQGPLET---VTLLPVARTDAALYACRILTEAGAQLSTPVL--LSVLY 794
                  R+G  +    LE    +T+L V + D+  Y C  + E G    T  L     L 
Sbjct: 8188 KDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLI 8247

Query: 795  PPDRPK-LSALLDMGQGH-MALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQA 852
            PP   K LS  ++  +G+   L      S+P+ +    +   +  TS           + 
Sbjct: 8248 PPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTS---------NCEI 8298

Query: 853  KAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRG-----AWVQVSPSPELQ 907
              + N+L L+VR+ G+ D+G Y C+ +N  GS+  +    ++       + Q      + 
Sbjct: 8299 TFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVS 8358

Query: 908  EGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAA---------ITLTQAGAY 958
            EG+ V LSC V    P     +W + G+ ++ S   +  FA+         +    +G Y
Sbjct: 8359 EGEYVQLSCHVQGSEP--IRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDY 8416

Query: 959  HCQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRL 1017
             C+A    GS TT     I    + AP   T    +D   GRL  +        P  +R+
Sbjct: 8417 VCKASNVAGSDTTKSKVTIKDKPAVAP--ATKKAAVD---GRLFFV------SEPQSIRV 8465

Query: 1018 LHGDRLVASTLQGVGGPE--------------GSSPRLHVAVAPNTLRLEIHGAMLEDEG 1063
            +  ++  A+ +  VGG                    R+ +    +  +LEI      D G
Sbjct: 8466 V--EKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSG 8523

Query: 1064 VYICEASNTLGQASASADFDAQAVNVQV 1091
            +Y C A N  G+  ++       VN+QV
Sbjct: 8524 LYRCVAFNEHGEIESN-------VNLQV 8544



 Score =  116 bits (290), Expect = 2e-25
 Identities = 333/1668 (19%), Positives = 588/1668 (35%), Gaps = 232/1668 (13%)

Query: 106  QPEDSGSYNFRFEISEVNRWS-DVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPY 164
            + +DSG Y F  + ++V R S   +  ++ +   P        ++ ++G+ +D  C    
Sbjct: 4642 EKKDSGEYTFEVQ-NDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLEC---I 4697

Query: 165  VCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMA-MSWQDHGRILRCQLSVAN 223
            V     + +QW   D   S    S+K++ +   +   L ++ +   D G       + A 
Sbjct: 4698 VAGSHPISIQWFKDDQEISA---SEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAG 4754

Query: 224  HRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRL 283
            H  Q   HL VK  P  V+    P  +++ P   V L   V  + P   +IKW KD   L
Sbjct: 4755 HN-QCSGHLTVKEPPYFVE---KPQSQDVNPNTRVQLKALVGGTAPM--TIKWFKDNKEL 4808

Query: 284  QTKTG----------VLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEV----- 328
             +              L L  A  +D+G Y CQ  N VG+  S      +F+ E      
Sbjct: 4809 HSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKAT---LFVKEPPQFIK 4865

Query: 329  QVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH---------TLRLHL 379
            + SP   +   Q+ T  C         +R SWY +   +     H         T ++  
Sbjct: 4866 KPSPVLVLRNGQSTTFECQITGTPK--IRVSWYLDGNEITAIQKHGISFIDGLATFQISG 4923

Query: 380  ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPP-----LTPV-LTAFLETQAGLVGILHC 433
            A   ++G Y CE +N  G+  S  + + V  PP     L PV +  + + +      L C
Sbjct: 4924 ARVENSGTYVCEARNDAGTA-SCSIELKVKEPPTFIRELKPVEVVKYSDVE------LEC 4976

Query: 434  SVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSA 493
             V   P   +        + S       S +++ T   +   L I   + +D+GEY+C  
Sbjct: 4977 EVTGTPPFEVTWLKNNREIRS-------SKKYTLTDRVSVFNLHITKCDPSDTGEYQCIV 5029

Query: 494  TNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH 553
            +N  G+ + +           I            + + +S ++ +P    +W  +  +L 
Sbjct: 5030 SNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILD 5089

Query: 554  EGPG---------SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFT 604
            E            ++L + +  +  +G Y C+A++          A L V  P +     
Sbjct: 5090 EDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVE--RCYAFLLVQEPAQIVEKA 5147

Query: 605  TRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMK 664
              +D+            L C V   P  +++ L   + +  S                  
Sbjct: 5148 KSVDVTEKDPMT-----LECVVAGTPELKVKWLKDGKQIVPSR--------------YFS 5188

Query: 665  VTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQE--- 721
            ++   N+    I + + ++ G Y  +  N  G++S  A    +     I PS T +    
Sbjct: 5189 MSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYL--RVLDQNIPPSFTKKLTKM 5246

Query: 722  ----GTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLETVTLLPVARTD 768
                G+  ++ C VS      P +  WF++G          L       ++ +  +   D
Sbjct: 5247 DKVLGSSIHMECKVS---GSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELED 5303

Query: 769  AALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLA 828
             A Y C++   AG    + +L +V  PP     S L+  G+   A+   TV+ +  A+L 
Sbjct: 5304 TANYTCKVSNVAGDDACSGIL-TVKEPP-----SFLVKPGR-QQAIPDSTVEFK--AILK 5354

Query: 829  LFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN-- 886
                  +       ++ S  +     E ++  L +  +    +G Y C  TN +GS +  
Sbjct: 5355 GTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCT 5414

Query: 887  TSLFFQVRGAWVQ-VSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTS--- 942
            T L       +V+ +  S  ++ G +  L C++  G PE     W+R+   L  S     
Sbjct: 5415 TMLLVTEPPKFVKKLEASKIVKAGDSSRLECKI-AGSPE-IRVVWFRNEHELPASDKYRM 5472

Query: 943  ------ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTG 996
                  A ++   ++   +G + C+AQ P  +T+     I   V   P   +   +++T 
Sbjct: 5473 TFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVI---VKEPPVFSSFPPIVETL 5529

Query: 997  PGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHG 1056
                  L C +   PP ++      R + S           S +  +A       + I  
Sbjct: 5530 KNAEVSLECELSGTPPFEVVWYKDKRQLRS-----------SKKYKIASKNFHTSIHILN 5578

Query: 1057 AMLEDEGVYICEASNTLGQASASADFDAQAVN--VQVWPGATVREGQLVNLTCLVWTTHP 1114
                D G Y C+A N +G  +       +     V      TV  G+   L   +    P
Sbjct: 5579 VDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQP 5638

Query: 1115 AQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRN 1174
              +   W ++ ++ +   S  +    V +  + +     P  A +    I  D       
Sbjct: 5639 --IFVQWLKEKEEVI-RESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENM 5695

Query: 1175 LRLTYL-----LESHG------GQLALVLCTVDSRPPAQLALSHAGRLLASSTAA--SVP 1221
              L  L     +E  G      G+   + C V   P   +     G+LL SS     S  
Sbjct: 5696 ATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFY 5755

Query: 1222 NTLR-LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE------- 1273
            N +  L +   + +D G Y+   ++ +G+++ +         V+   + AVP        
Sbjct: 5756 NKISSLRILSVERQDAGTYTFQVQNNVGKSSCTA--------VVDVSDRAVPPSFTRRLK 5807

Query: 1274 ------GAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFL--VAT-------RAH 1318
                  GA   + C   A  +P    W+H    +  G     +F   V T        + 
Sbjct: 5808 NTGGVLGASCILECK-VAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSD 5866

Query: 1319 AGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELA 1378
             G Y+C A +  G+   R A L V   P         +            +   PP ++ 
Sbjct: 5867 MGNYTCVAANVAGSDECR-AVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVN 5925

Query: 1379 LSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIG 1438
                 + L      +     T    VA   L L   D+    + Y C   N  G  S   
Sbjct: 5926 WFRGARELVKGDRCNIYFEDT----VAE--LELFNIDISQSGE-YTCVVSNNAGQASCTT 5978

Query: 1439 RLQVEGARVVAEPGLD--VPEGAALNLSCRLLGGPGPVG--------NSTFAWFWNDRRL 1488
            RL V+      +   D  V  G ++ L     G   P+         N T +   N   +
Sbjct: 5979 RLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTL-PISVTWKKDGFNITTSEKCNI--V 6035

Query: 1489 HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGL 1548
              E    L   +  +  AG Y C  E   G       ++  L PP   T +  +E   G 
Sbjct: 6036 TTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCG-ALVSTLEPPYFVTELEPLEAAVGD 6094

Query: 1549 RGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQ 1608
               L C+V   P  +++ + G   +  +        P      + N   +    +  +D 
Sbjct: 6095 SVSLQCQVAGTPEITVSWYKGDTKLRPT--------PEYRTYFTNNVATLVFNKVNINDS 6146

Query: 1609 GEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLLL 1656
            GEY C A N +G+AS+ T F ++       F + L  +   VGL + L
Sbjct: 6147 GEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTL 6194



 Score =  113 bits (283), Expect = 1e-24
 Identities = 195/869 (22%), Positives = 321/869 (36%), Gaps = 134/869 (15%)

Query: 98   CNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVD 157
            C L +  L+  DSG Y     I+     SD     +TV E P       P+++L GT V 
Sbjct: 7737 CALTVNMLEESDSGDYTC---IATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVT 7793

Query: 158  FNCSTPYVCLQEQVRLQW-QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILR 216
            F   T  V       + W +G          +   E + V  LE   +  S         
Sbjct: 7794 F---TSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDS-VAELELFDVDTSQSGE---YT 7846

Query: 217  CQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW 276
            C +S    +A    HL +K   K VK L   +  +I  G+ + L      + P   S+ W
Sbjct: 7847 CIVSNEAGKASCTTHLYIKAPAKFVKRL---NDYSIEKGKPLILEGTFTGTPPI--SVTW 7901

Query: 277  LKDGVRLQT----------KTGVLHLPQAAWSDAGVYTCQAENGVGS--------LVSPP 318
             K+G+ +            K+ +L +P +   DAG Y C  EN  G         ++ PP
Sbjct: 7902 KKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPP 7961

Query: 319  ISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTL--R 376
              +       Q+ P   +    + +L C        ++  SWYK    L    ++ +  R
Sbjct: 7962 YFVK------QLEPV-KVSVGDSASLQCQLAGTP--EIGVSWYKGDTKLRPTTTYKMHFR 8012

Query: 377  LHLATRA-------DTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFL---ETQAG 426
             ++AT         D+G Y C+ +N  G E S    + V    L P  +  L   +   G
Sbjct: 8013 NNVATLVFNQVDINDSGEYICKAENSVG-EVSASTFLTVQEQKLPPSFSRQLRDVQETVG 8071

Query: 427  LVGILHCSVV-SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETD 485
            L  +  C++  SEP++      G  +          SP    +   N+  L I   + + 
Sbjct: 8072 LPVVFDCAISGSEPISVSWYKDGKPL--------KDSPNVQTSFLDNTATLNIFKTDRSL 8123

Query: 486  SGEYKCSATNSLGNATSTLDFHANAAR------LLISPAAEVVEGQAVTLSCRSGLSPTP 539
            +G+Y C+ATN +G+A+S+        +      + ++P   VV G++    C   ++ T 
Sbjct: 8124 AGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVV-GESADFECH--VTGTQ 8180

Query: 540  DARFSWYLNGALLHEGP---------GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPA 590
              + SW  +   +  G           + L +      D+G Y C A +       S  A
Sbjct: 8181 PIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVN--EVGKDSCTA 8238

Query: 591  VLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSG 650
             L +      P+FT RL  +      G    L  RV    P  +     +  +  +    
Sbjct: 8239 QLNIKERLIPPSFTKRLS-ETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPT---- 8293

Query: 651  GGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNA-STSATFNGQAT 709
               S C       ++T   N L +++    + + GLY C+ SN  G+A  TS+    +  
Sbjct: 8294 ---SNC-------EITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPK 8343

Query: 710  VLAIAPSH----TLQEGTEANLTCNVSREAAGSPANFSWFRNG----------VLWAQGP 755
               +   H    T+ EG    L+C+V       P    W + G            +A G 
Sbjct: 8344 KPPVFDQHLTPVTVSEGEYVQLSCHVQ---GSEPIRIQWLKAGREIKPSDRCSFSFASGT 8400

Query: 756  LETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALF 815
               + L  VA+ D+  Y C+    AG+  +     S +   D+P ++           LF
Sbjct: 8401 A-VLELRDVAKADSGDYVCKASNVAGSDTTK----SKVTIKDKPAVAPATKKAAVDGRLF 8455

Query: 816  -------ICTVDSRPLALLALFHGEHL----LATSLGPQVPSHGRFQAKAEANSLKLEVR 864
                   I  V+      +A   G+ +           Q+   GR     + +  KLE+R
Sbjct: 8456 FVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIR 8515

Query: 865  ELGLGDSGSYRCEATNVLGSSNTSLFFQV 893
            +    DSG YRC A N  G   +++  QV
Sbjct: 8516 DTTKTDSGLYRCVAFNEHGEIESNVNLQV 8544



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 94/411 (22%), Positives = 165/411 (40%), Gaps = 72/411 (17%)

Query: 146  SPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLE-TLHM 204
            +PV+ + G   DF C   +V   + +++ W     +R +  +  K++   + +LE + H+
Sbjct: 8160 APVDAVVGESADFEC---HVTGTQPIKVSWAKD--SREIR-SGGKYQ---ISYLENSAHL 8210

Query: 205  AMSWQDHGRILRCQLSVANHRAQ----SEIHLQVKYAPKGVKILLSPSGRNILPGELVTL 260
             +   D G   +      N   +    ++++++ +  P      LS +      G    L
Sbjct: 8211 TVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEET-EGNSFKL 8269

Query: 261  TCQVNSSYPAVSSIKWLKDGVRLQ----------TKTGVLHLPQAAWSDAGVYTCQAENG 310
              +V  S P   ++ W K+ + +Q            T VL + +A  +DAG+YTC+  N 
Sbjct: 8270 EGRVAGSQPI--TVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSND 8327

Query: 311  VGS-------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYK- 362
             GS       ++  P    +F  +  ++P   + E + V L C+     P  +R  W K 
Sbjct: 8328 AGSALCTSSIVIKEPKKPPVF--DQHLTPV-TVSEGEYVQLSCHVQGSEP--IRIQWLKA 8382

Query: 363  -NHVLLEDAHSHT-------LRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLT 414
               +   D  S +       L L    +AD+G Y C+  NV GS+ +     + + P + 
Sbjct: 8383 GREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVA 8442

Query: 415  PVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGP--- 471
            P        +A + G L    VSEP +  V+        +  G  D  P    T G    
Sbjct: 8443 PATK-----KAAVDGRLF--FVSEPQSIRVVEKTTATFIAKVG-GDPIPNVKWTKGKWRQ 8494

Query: 472  -------------NSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN 509
                         +  +LEIRD  +TDSG Y+C A N  G   S ++   +
Sbjct: 8495 LNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVD 8545



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 156/754 (20%), Positives = 265/754 (35%), Gaps = 114/754 (15%)

Query: 227   QSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTK 286
             +S  HL+VK  P+ + +L       +  GE  T  C++  SY  +  ++W   G +L+  
Sbjct: 12184 KSSAHLRVK--PRVIGLLRPLKDVTVTAGETATFDCEL--SYEDIP-VEWYLKGKKLEPS 12238

Query: 287   TGVLHLPQAAWSDAGVYTCQAEN-GVGSLVSPPISLH--IFMAEVQVSPAGPILENQTV- 342
               V+   +       +   + E+ G   L +     H  +F+ E  V    P LE+QTV 
Sbjct: 12239 DKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKP-LEDQTVE 12297

Query: 343   -----TLVCNTPNEAPSDLRYSWYKN---------HVLLEDAHSHTLRLHLATRADTGFY 388
                   L C    E   + +  W+KN         + ++ D     L +H  T  D   Y
Sbjct: 12298 EGATAVLECEVSRE---NAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTY 12354

Query: 389   FCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHG 448
              C+ ++    + S  ++VV  H      LT  L+ +   +    C +  E         G
Sbjct: 12355 TCDAKDF---KTSCNLNVVPPHVEFLRPLTD-LQVREKEMARFECELSRENAKVKWFKDG 12410

Query: 449   GHILASTSGDSDHSPRFSGTSGPNSLR-LEIRDLEETDSGEYKCSA-TNSLGNATSTLDF 506
               I      D              ++R L I      D  EY C   T       + L+ 
Sbjct: 12411 AEIKKGKKYD---------IISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEE 12461

Query: 507   HANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGA---------LLHEGPG 557
              A   + L +   EV E   + L C       P A   WY             +L EG  
Sbjct: 12462 EAVFTKNLAN--IEVSETDTIKLVCEVS---KPGAEVIWYKGDEEIIETGRYEILTEGRK 12516

Query: 558   SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTR-LDLDAAGAGA 616
               L++  A   DAG+Y+CR         PSS     V        F ++  +L+      
Sbjct: 12517 RILVIQNAHLEDAGNYNCRL--------PSSRTDGKVKVHELAAEFISKPQNLEIL---E 12565

Query: 617   GRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEI 676
             G +   +C + S     +Q    D+    +L SG           R+ V K         
Sbjct: 12566 GEKAEFVCSI-SKESFPVQWKRDDK----TLESGDKYDVIADGKKRVLVVK--------- 12611

Query: 677   HNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAA 736
              +  L++ G Y+     A   A+   T   +  ++       ++E  E    C V+ E A
Sbjct: 12612 -DATLQDMGTYVVMVGAA--RAAAHLTVIEKLRIVVPLKDTRVKEQQEVVFNCEVNTEGA 12668

Query: 737   GSPANFSWFRNG---------VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTP 787
              +     WFRN          ++  +  + T+ +      D A Y   +    G  + + 
Sbjct: 12669 KA----KWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSA 12724

Query: 788   VLLSVLYPPDRPKLSALLDMG--QGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVP 845
               L ++   D   +  L D+   +     F C V+   + L    +GE         +VP
Sbjct: 12725 ANL-IVEEEDLRIVEPLKDIETMEKKSVTFWCKVNRLNVTLKWTKNGE---------EVP 12774

Query: 846   SHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPE 905
                R   + +     L +++ G  D G Y   A      +   L  +    +V+      
Sbjct: 12775 FDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAEL-LIIEAPTEFVEHLEDQT 12833

Query: 906   LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQE 939
             + E    V SCQ+     E  + +WYR+G+ ++E
Sbjct: 12834 VTEFDDAVFSCQLSR---EKANVKWYRNGREIKE 12864



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 140/761 (18%), Positives = 258/761 (33%), Gaps = 147/761 (19%)

Query: 231   HLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTK---- 286
             HL V   PK  + L + + +     E+  LTC V SS      + W KDG +L+      
Sbjct: 32711 HLPVSAPPKITQFLKAEASK-----EIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQ 32765

Query: 287   -------TGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPI--------SLHIFMAEV--- 328
                    T  L +     SD G Y C+  +G G      +        S+H  ++++   
Sbjct: 32766 FHYSADGTYELKINNLTESDQGEYVCEI-SGEGGTSKTNLQFMGQAFKSIHEKVSKISET 32824

Query: 329   --------------QVSPAGPI-----------LENQTVTL--VCNTPNEAPSDLRYS-- 359
                           +  P  P            L++ TV+   V     +A  + R +  
Sbjct: 32825 KKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAI 32884

Query: 360   WYKN---------HVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNH 410
             W K+         + L ED     L +H    +D+G Y C V+N  GS  S         
Sbjct: 32885 WTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSS-------- 32936

Query: 411   PPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSG 470
                   + A  +T+A  V     S ++     +V         S         + S    
Sbjct: 32937 --CKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEE-----ISQKALRSEEIKMSEAKS 32989

Query: 471   PNSLRLEIRDLEETDSGEYKCSATNSL----------GNATSTLDFHANAARLLISPAAE 520
                L L+    +   S E K SA  SL            + ++ +   +A     S    
Sbjct: 32990 QEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMS 33049

Query: 521   VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH---------EGPGSSLLLPAASSTDAG 571
             + EGQ + L  ++ ++   D +  W LNG  L           G   +L +  AS  D G
Sbjct: 33050 INEGQRLVL--KANIAGATDVK--WVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEG 33105

Query: 572   SYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPP 631
                C ++             L+       P F ++    +     G+  L  C +  +P 
Sbjct: 33106 ILTCISKTKEGIVKCQYDLTLSKELSD-APAFISQ--PRSQNINEGQNVLFTCEISGEPS 33162

Query: 632   ARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEA 691
               ++    +  ++               S  + ++++ N+  +EI N  + + G Y  +A
Sbjct: 33163 PEIEWFKNNLPIS--------------ISSNVSISRSRNVYSLEIRNASVSDSGKYTIKA 33208

Query: 692   SNALGNASTSATFNGQATVLAIAPSHTLQEGTEANL-----TCNVSREAAGSPANFSWFR 746
              N  G  S +A+      V   +    L+   + +L     + +V   A+   A+FS F 
Sbjct: 33209 KNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFS 33268

Query: 747   NGVLWAQGPLETVTLLP----------VARTDAALYACRILTEAGAQLSTPVLLSVLYPP 796
             +    +   ++  ++            V  + ++      +T+  +  S  +   +   P
Sbjct: 33269 SSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIP 33328

Query: 797   DRPKLSAL---LDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAK 853
               PK+ AL   + + +G +    C     P   +    G   + +         GRF  +
Sbjct: 33329 --PKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQ------EQGRFHIE 33380

Query: 854   AEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894
                +   L + ++   D G Y     N  GS + ++   +R
Sbjct: 33381 NTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 33421



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 189/907 (20%), Positives = 305/907 (33%), Gaps = 173/907 (19%)

Query: 131   TLVTVTEEPRVPTIASP---VELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFN 187
             T   VT E R+  +  P   VE+  G    F         +  V  QW+ +    + + +
Sbjct: 11740 TKANVTVEARLIKVEKPLYGVEVFVGETAHFEIELS----EPDVHGQWKLKGQPLTASPD 11795

Query: 188   SQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANH------RAQSEIHLQVKYAPKGV 241
              +  E  G  H+  LH             CQL +          A+S  +L+VK  P   
Sbjct: 11796 CEIIED-GKKHILILH------------NCQLGMTGEVSFQAANAKSAANLKVKELPL-- 11840

Query: 242   KILLSP-SGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ-------TKTGVLH-- 291
              I ++P S   +   +     C+V+       + +WLK    +         K G  H  
Sbjct: 11841 -IFITPLSDVKVFEKDEAKFECEVSRE---PKTFRWLKGTQEITGDDRFELIKDGTKHSM 11896

Query: 292   -LPQAAWSDAGVYTCQAENG--VGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNT 348
              +  AA+ D   Y  +AE+    G L+   I L        ++P   +   +  + V  T
Sbjct: 11897 VIKSAAFEDEAKYMFEAEDKHTSGKLIIEGIRLKF------LTPLKDVTAKEKESAVF-T 11949

Query: 349   PNEAPSDLRYSWYKNHVLLEDAHSHTL----RLHLATRADTGFYFCEVQNVH--GSERSG 402
                +  ++R  W+KN   L    S ++    + H  T  D          V   G     
Sbjct: 11950 VELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEA 12009

Query: 403   PVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSG--DSD 460
              ++V+   P  T  L  +   +   V IL C +            G  I  S +    +D
Sbjct: 12010 KLTVLEGDPYFTGKLQDYTGVEKDEV-ILQCEISKADAPVKWFKDGKEIKPSKNAVIKAD 12068

Query: 461   HSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAE 520
                R           L ++   ++D G+Y C         +  LD      +L + P   
Sbjct: 12069 GKKRM----------LILKKALKSDIGQYTCDCGTD--KTSGKLDIEDREIKL-VRPLHS 12115

Query: 521   VVEGQAVTLSCRSGLSPTPDARFSWYLNGALL---------HEGPGSSLLLPAASSTDAG 571
             V   +  T    + +S   D   +W L G  L          EG   SL+L        G
Sbjct: 12116 VEVMETETARFETEISED-DIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTG 12174

Query: 572   SYHCRARDGHSASGPS-SPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVD-SD 629
                 +A +  S++     P V+ +L P +  T T           AG      C +   D
Sbjct: 12175 GVDFQAANVKSSAHLRVKPRVIGLLRPLKDVTVT-----------AGETATFDCELSYED 12223

Query: 630   PPARLQLLHK-----DRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEE 684
              P    L  K     D+VV  S                        +  + + +  LE+ 
Sbjct: 12224 IPVEWYLKGKKLEPSDKVVPRS---------------------EGKVHTLTLRDVKLEDA 12262

Query: 685   GLYLCEASNALGNASTSATFNGQATVLAIAP--SHTLQEGTEANLTCNVSREAAGSPANF 742
             G     A +   +A+    F  +  V    P    T++EG  A L C VSRE     A  
Sbjct: 12263 GEVQLTAKDFKTHANL---FVKEPPVEFTKPLEDQTVEEGATAVLECEVSRE----NAKV 12315

Query: 743   SWFRNGV---------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVL 793
              WF+NG          + A G +  + +      D   Y C           T   L+V+
Sbjct: 12316 KWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTC-----DAKDFKTSCNLNVV 12370

Query: 794   YPPDRPKLSALLDM--GQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQ 851
              PP    L  L D+   +  MA F C + SR  A +  F          G ++    ++ 
Sbjct: 12371 -PPHVEFLRPLTDLQVREKEMARFECEL-SRENAKVKWFKD--------GAEIKKGKKYD 12420

Query: 852   AKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQA 911
               ++     L + +  L D   Y CE      S   ++  +    + +   + E+ E   
Sbjct: 12421 IISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTV-LEEEAVFTKNLANIEVSETDT 12479

Query: 912   VVLSCQVHTGVPEGTSYRWYRDGQPLQES------TSATLRFAAIT---LTQAGAYHCQA 962
             + L C+V      G    WY+  + + E+      T    R   I    L  AG Y+C  
Sbjct: 12480 IKLVCEVS---KPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNC-- 12534

Query: 963   QAPGSAT 969
             + P S T
Sbjct: 12535 RLPSSRT 12541



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 105/501 (20%), Positives = 174/501 (34%), Gaps = 74/501 (14%)

Query: 1162  RPITLDVLYAPRNLRLTYLLESHG---GQLALVLCTVDSRPPAQLALSHAGRLLASSTAA 1218
             +P TLD  +APR   +T  + SH    GQ    +  V S+P A++   H G  L  S+  
Sbjct: 32366 QPFTLD--HAPR---ITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKI 32420

Query: 1219  SVPNT---LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGA 1275
                NT   L LE+      D G Y     +  G+A+    L + G            E  
Sbjct: 32421 HYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEV 32480

Query: 1276  PITVTCADPAAHAPTLYTWYHNGRWLQEGPAASL-SFLVATRAHAGAYSCQAQDAQGTRS 1334
             P +V        A  + ++              + S +  TR    +Y   A     + +
Sbjct: 32481 PRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAA 32540

Query: 1335  SRPAALQVLYAPQ--DAVLSSFRDSRARSMAVIQ-------CTVDSEPPAELALSHDGKV 1385
                 +L+     +     L++   ++ RSM V +       C  D EP   +     G+V
Sbjct: 32541 LEEKSLEEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQV 32600

Query: 1386  LATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQVEG 1444
             L+TS+           V   +     ++  V A D+  Y    +N  G       L ++ 
Sbjct: 32601 LSTSA--------RHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQK 32652

Query: 1445  ARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARA 1504
             ARV  +     P           +  P P   S  A     R    EP            
Sbjct: 32653 ARVTEKAVTSPPR----------VKSPEPRVKSPEAVKSPKRVKSPEP------------ 32690

Query: 1505  QAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASL 1564
                  H  A  PT    +    ++ L     P +  F++ E            S+ +A L
Sbjct: 32691 ----SHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEA-----------SKEIAKL 32735

Query: 1565  TLHLGSRLVASSQ----PQGAPAEPHIHV---LASPNALRVDIEALRPSDQGEYICSASN 1617
             T  + S ++ + +      G   + + H     ++     + I  L  SDQGEY+C  S 
Sbjct: 32736 TCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISG 32795

Query: 1618  VLGSASTSTYFGVRALHRLHQ 1638
               G++ T+  F  +A   +H+
Sbjct: 32796 EGGTSKTNLQFMGQAFKSIHE 32816



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 61/293 (20%), Positives = 99/293 (33%), Gaps = 38/293 (12%)

Query: 810   GHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869
             G    FI  V S+P A +  +H         G ++    +      +  L LE+ +    
Sbjct: 32388 GQNTRFILNVQSKPTAEVKWYHN--------GVELQESSKIHYTNTSGVLTLEILDCHTD 32439

Query: 870   DSGSYRCEATN------------VLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQ 917
             DSG+YR   TN            V G   T+   Q R   V  S  PEL   +A  +S  
Sbjct: 32440 DSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSVFPELTRTEAYAVSSF 32499

Query: 918   VHTGVPE-GTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPI 976
               T   E  +S R  +        + ++   +A    ++ A   ++    S T  +   +
Sbjct: 32500 KKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTL 32559

Query: 977   SLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEG 1036
             +  +   PR +T+        G      C  D +P   +  L   ++++           
Sbjct: 32560 AARILTKPRSMTVY------EGESARFSCDTDGEPVPTVTWLRKGQVLS----------- 32602

Query: 1037  SSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNV 1089
             +S R  V         EI      DEG Y     N+ G+  A      Q   V
Sbjct: 32603 TSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARV 32655



 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 72/349 (20%), Positives = 129/349 (36%), Gaps = 36/349 (10%)

Query: 187   NSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLS 246
             NS+++     G  +TL +  +      IL C         + +  L +          +S
Sbjct: 33079 NSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFIS 33138

Query: 247   -PSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQA 295
              P  +NI  G+ V  TC++ S  P+   I+W K+ + +   + V          L +  A
Sbjct: 33139 QPRSQNINEGQNVLFTCEI-SGEPS-PEIEWFKNNLPISISSNVSISRSRNVYSLEIRNA 33196

Query: 296   AWSDAGVYTCQAENGVGS-----------LVSPPISLHIFMAEVQVSPAGPILENQTVTL 344
             + SD+G YT +A+N  G            LV  P    +       S  G    +Q+V +
Sbjct: 33197 SVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGS-FSSQSVQM 33255

Query: 345   VCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRA---DTGFYFCEVQNVHGSERS 401
               +    + S    S   +   ++ A      +     +    +   F  + N+   E S
Sbjct: 33256 SASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESS 33315

Query: 402   GPVSV---VVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGD 458
                 +   +   PP    L + +    G V  + C+   EP   +  S GG  +      
Sbjct: 33316 TSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKI-----H 33370

Query: 459   SDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFH 507
             S    RF   +  +   L I D+++ D G Y  S  N  G+ ++T++ H
Sbjct: 33371 SQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIH 33419



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 143/705 (20%), Positives = 240/705 (34%), Gaps = 123/705 (17%)

Query: 426   GLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETD 485
             G   I  C V      T  +  G +I          SP+    +     +L I D++ +D
Sbjct: 11133 GSSAIFECLVSPSTAITTWMKDGSNIR--------ESPKHRFIADGKDRKLHIIDVQLSD 11184

Query: 486   SGEYKC--SATNSLGNATSTLDFHANAARLL--ISPAAEVVEGQAVTLSCRSGLSPTPDA 541
             +GEY C     N    +T+ L       R +  +     VV+GQ + LSC   L+   D 
Sbjct: 11185 AGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCE--LNKERDV 11242

Query: 542   RFSWYLNGALLHEGPG----------SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAV 591
                W  +G ++ E PG           +L +  A  TDAG+Y     + ++    S   V
Sbjct: 11243 --VWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKV 11300

Query: 592   LTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGG 651
             + V+   R        D      G     +  C +  D P        D + A       
Sbjct: 11301 VEVI---RDWLVKPIRDQHVKPKGT---AIFACDIAKDTPNIKWFKGYDEIPAEP----- 11349

Query: 652   GCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVL 711
                     + + ++ +  N L ++I N + E+   Y  E     G    +    G+  V 
Sbjct: 11350 --------NDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIE---GKRYPAKLTLGEREVE 11398

Query: 712   AIAPSH--TLQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDA 769
              + P    T+ E   A+    +S   A  P    W   G L    P              
Sbjct: 11399 LLKPIEDVTIYEKESASFDAEISE--ADIPG--QWKLKGELLRPSP-------------- 11440

Query: 770   ALYACRILTEAGAQLST--PVLL----SVLYPPDRPKLSALLDMGQGHMALFI----CTV 819
                 C I  E G +  T   V L     VLY       +A+L + +  +   +     TV
Sbjct: 11441 ---TCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTV 11497

Query: 820   DSRPLALL-ALFHGEHLLATSLGPQ-VPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCE 877
               R  A    +   E  +  S GP  + S  +F   A+     L + +    D G Y  E
Sbjct: 11498 PERRQARFECVLTREANVIWSKGPDIIKSSDKFDIIADGKKHILVINDSQFDDEGVYTAE 11557

Query: 878   ATNVLGSSNTSLFF--QVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQ 935
                V G   ++  F   +R  ++       ++EG+     C++     E     W+++  
Sbjct: 11558 ---VEGKKTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCELS---HEKMHVVWFKNDA 11611

Query: 936   PL---------QESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRH 986
              L          E  +  L    +TL        Q +        L++   L V  A  +
Sbjct: 11612 KLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQVK-------ELSSTAQLKVLEADPY 11664

Query: 987   VTLTTLMDTGPGRLGLLL-CRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAV 1045
              T+     T   +  + L C V  D P +     G+ +V             SP+  +  
Sbjct: 11665 FTVKLHDKTAVEKDEITLKCEVSKDVPVKW-FKDGEEIV------------PSPKYSIKA 11711

Query: 1046  APNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQ 1090
                   L+I  A L+D+G Y+C+      +  A+   +A+ + V+
Sbjct: 11712 DGLRRILKIKKADLKDKGEYVCDCGT--DKTKANVTVEARLIKVE 11754



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 47/173 (27%), Positives = 71/173 (41%), Gaps = 18/173 (10%)

Query: 475 RLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR-----LLISPAAEVVEGQAVTL 529
           +L I  + + +SG Y   ATN  G ATST +    A       +    +  V +G  V L
Sbjct: 64  KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRL 123

Query: 530 SCRSGLSPTPDARFSWYLNGA---------LLHEGPGSSLLLPAASSTDAGSYHCRARDG 580
             R    PTP  +F  Y +GA         +  EG   SLL+  A   D+G+Y   A   
Sbjct: 124 QVRVTGIPTPVVKF--YRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNAT-- 179

Query: 581 HSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPAR 633
           +S    +S A L V      P   T+  +  A     R+  +  ++++   AR
Sbjct: 180 NSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDAR 232



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 98/463 (21%), Positives = 168/463 (36%), Gaps = 59/463 (12%)

Query: 1052  LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWP---GATVREGQLVNLTC- 1107
             L I+ +  +DEGVY  E          SA      + ++        TV+EG+     C 
Sbjct: 11541 LVINDSQFDDEGVYTAEVEGK----KTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCE 11596

Query: 1108  -------LVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRL 1160
                    +VW  + A+L  +           H + +  VT+ D +  +  V        L
Sbjct: 11597 LSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQV------KEL 11650

Query: 1161  SRPITLDVLYAPRNLRLTYLLESHGGQLALVL-CTVDSRPPAQLALSHAGRLLASSTAAS 1219
             S    L VL A     +    ++   +  + L C V    P +        ++ S   + 
Sbjct: 11651 SSTAQLKVLEADPYFTVKLHDKTAVEKDEITLKCEVSKDVPVKW-FKDGEEIVPSPKYSI 11709

Query: 1220  VPNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGV-RVILAPEAAVPEGAP 1276
               + LR  L+++    +D+G Y C   +   +AN ++E RL  V + +   E  V E A 
Sbjct: 11710 KADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIKVEKPLYGVEVFVGETAH 11769

Query: 1277  ITVTCADPAAHAPTLYTWYHNGRWLQEGPAASL------SFLVATRAH---AGAYSCQAQ 1327
               +  ++P  H      W   G+ L   P   +        L+         G  S QA 
Sbjct: 11770 FEIELSEPDVHG----QWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAA 11825

Query: 1328  DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLA 1387
             +A+   + +   L +++    + +  F    A+     +C V  EP     L    ++  
Sbjct: 11826 NAKSAANLKVKELPLIFITPLSDVKVFEKDEAK----FECEVSREPKTFRWLKGTQEITG 11881

Query: 1388  TSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARV 1447
                    +  GT H  V ++A     +D    +  Y+  A++      T G+L +EG R+
Sbjct: 11882 -DDRFELIKDGTKHSMVIKSA---AFED----EAKYMFEAEDK----HTSGKLIIEGIRL 11929

Query: 1448  -VAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLH 1489
                 P  DV    A      +        N    WF ND+RLH
Sbjct: 11930 KFLTPLKDV---TAKEKESAVFTVELSHDNIRVKWFKNDQRLH 11969



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 42/167 (25%), Positives = 62/167 (37%), Gaps = 22/167 (13%)

Query: 930  WYRDGQPLQEST-----------SATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISL 978
            W+RDGQ +  ST            A L   A+T   +G Y  +A       TS A  +  
Sbjct: 39   WFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVK 98

Query: 979  HVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSS 1038
              +  P  V     M    G    L  RV   P   ++       + S+L      EG  
Sbjct: 99   AETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDL 158

Query: 1039 PRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQ 1085
              L +A A             ED G Y   A+N++G+A+++A+   Q
Sbjct: 159  YSLLIAEA-----------YPEDSGTYSVNATNSVGRATSTAELLVQ 194



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 41/190 (21%), Positives = 68/190 (35%), Gaps = 25/190 (13%)

Query: 901   SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQES---------TSATLRFAAIT 951
             S    + EGQ +VL   +       T  +W  +G  L  S         +  TL     +
Sbjct: 33045 STQMSINEGQRLVLKANI----AGATDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQAS 33100

Query: 952   LTQAGAYHCQAQAP-GSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSD 1010
                 G   C ++   G         +S  +S AP  ++     +   G+  L  C +  +
Sbjct: 33101 HRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGE 33160

Query: 1011  PPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEAS 1070
             P  ++     +            P   S  + ++ + N   LEI  A + D G Y  +A 
Sbjct: 33161 PSPEIEWFKNNL-----------PISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAK 33209

Query: 1071  NTLGQASASA 1080
             N  GQ SA+A
Sbjct: 33210 NFRGQCSATA 33219



 Score = 41.2 bits (95), Expect = 0.009
 Identities = 44/193 (22%), Positives = 77/193 (39%), Gaps = 31/193 (16%)

Query: 521 VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEG--PG---------SSLLLPAASSTD 569
           V+EG   T        P P+   SW+ +G ++     PG         + L +PA +  +
Sbjct: 17  VLEGSTATFEAHISGFPVPEV--SWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKAN 74

Query: 570 AGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSD 629
           +G Y  +A +G   +  +S A L V      P F  RL       G+  R  L  RV   
Sbjct: 75  SGRYSLKATNGSGQA--TSTAELLVKAETAPPNFVQRLQSMTVRQGSQVR--LQVRVTGI 130

Query: 630 PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLC 689
           P   ++       + +SL                ++++  +L  + I     E+ G Y  
Sbjct: 131 PTPVVKFYRDGAEIQSSLD--------------FQISQEGDLYSLLIAEAYPEDSGTYSV 176

Query: 690 EASNALGNASTSA 702
            A+N++G A+++A
Sbjct: 177 NATNSVGRATSTA 189



 Score = 41.2 bits (95), Expect = 0.009
 Identities = 30/111 (27%), Positives = 51/111 (45%), Gaps = 11/111 (9%)

Query: 398   SERSGPVSVVVNHPP----LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILA 453
             SE S PV+++  + P    L+  + + L  +AG    L  +V  +P+ T+     G +L 
Sbjct: 19278 SEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLK 19337

Query: 454   STSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTL 504
                G      R       N   LE+  +   DSG+Y  +A NS G+ ++T+
Sbjct: 19338 PAEGIKMAMQR-------NLCTLELFSVNRKDSGDYTITAENSSGSKSATI 19381



 Score = 40.4 bits (93), Expect = 0.015
 Identities = 44/189 (23%), Positives = 75/189 (39%), Gaps = 26/189 (13%)

Query: 721 EGTEANLTCNVSREAAGSPA-NFSWFRNGVLWAQGPLETV-----------TLLPVARTD 768
           EG+ A    ++S    G P    SWFR+G + +   L  V           T+  V + +
Sbjct: 19  EGSTATFEAHIS----GFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKAN 74

Query: 769 AALYACRILTEAGAQLSTPVLL--SVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLAL 826
           +  Y+ +    +G   ST  LL  +   PP+  +    + + QG        V   P  +
Sbjct: 75  SGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPV 134

Query: 827 LALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN 886
           +  +          G ++ S   FQ   E +   L + E    DSG+Y   ATN +G + 
Sbjct: 135 VKFYRD--------GAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRAT 186

Query: 887 TSLFFQVRG 895
           ++    V+G
Sbjct: 187 STAELLVQG 195



 Score = 40.0 bits (92), Expect = 0.019
 Identities = 70/336 (20%), Positives = 133/336 (39%), Gaps = 46/336 (13%)

Query: 68    QVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSD 127
             +V+ +  D +++E    GR E +     R+  L++++   ED+G+YN R   S  +    
Sbjct: 12492 EVIWYKGDEEIIET---GRYEILTEGRKRI--LVIQNAHLEDAGNYNCRLPSSRTDGKVK 12546

Query: 128   VKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFN 187
             V         +P+       +E+LEG + +F CS      +E   +QW+  D       +
Sbjct: 12547 VHELAAEFISKPQ------NLEILEGEKAEFVCSIS----KESFPVQWKRDDKTLE---S 12593

Query: 188   SQKFEPTGVGHLETLHMA-MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLS 246
               K++    G    L +   + QD G  +     V    A++  HL V    + ++I++ 
Sbjct: 12594 GDKYDVIADGKKRVLVVKDATLQDMGTYV-----VMVGAARAAAHLTV---IEKLRIVVP 12645

Query: 247   PSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDG----------VRLQTKTGVLHLPQAA 296
                  +   + V   C+VN+     +  KW ++           +  +     L +  A 
Sbjct: 12646 LKDTRVKEQQEVVFNCEVNTE---GAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAH 12702

Query: 297   WSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQ-VSPAGPI--LENQTVTLVCNTPNEAP 353
               D   Y     N  G  V    +L +   +++ V P   I  +E ++VT  C   N   
Sbjct: 12703 LDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKV-NRLN 12761

Query: 354   SDLRYSWYKNHVLLEDAHSHTL--RLHLATRADTGF 387
               L+++     V  ++  S+ +    H+ T  D GF
Sbjct: 12762 VTLKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGF 12797



 Score = 38.9 bits (89), Expect = 0.043
 Identities = 52/246 (21%), Positives = 97/246 (39%), Gaps = 59/246 (23%)

Query: 48   DVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEAR-FRGRTEFMGNPEHRVC------NL 100
            D+EVP+         YSG+ + +     P+ +E + +    E   N ++ +       NL
Sbjct: 2275 DIEVPES--------YSGELECI---VSPENIEGKWYHNDVELKSNGKYTITSRRGRQNL 2323

Query: 101  LLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNC 160
             +KD+  ED G Y+F           D K T   +  +PR      P+ +L+G      C
Sbjct: 2324 TVKDVTKEDQGEYSFVI---------DGKKTTCKLKMKPR------PIAILQGLSDQKVC 2368

Query: 161  STPYVCLQEQVRLQ-----WQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRIL 215
                V L+ +V L+     W           + Q+ +P+     + +H+ +  Q H  ++
Sbjct: 2369 EGDIVQLEVKVSLESVEGVWMK---------DGQEVQPS-----DRVHIVIDKQSHMLLI 2414

Query: 216  R--CQLSVANHR---AQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPA 270
                +    N+        +    + +   V ++      N++ G    L C+V  S P 
Sbjct: 2415 EDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLKDVNVIEGTKAVLECKV--SVPD 2472

Query: 271  VSSIKW 276
            V+S+KW
Sbjct: 2473 VTSVKW 2478



 Score = 38.9 bits (89), Expect = 0.043
 Identities = 38/165 (23%), Positives = 63/165 (38%), Gaps = 19/165 (11%)

Query: 1186  GQLALVLCTVDSRPPAQLALSHAGRLLASSTA---ASVPNTLRLELRGPQPRDEGFYSCS 1242
             G+ A + C +  RP   +     G+ L  S     +S   T  L +   +  DEG Y+C 
Sbjct: 30547 GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCI 30606

Query: 1243  ARSPLGQANTSLELRLEGVRVI-----LAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN 1297
             A + +G+  TS +L L+          L  +     G+ + +         P + TW+H 
Sbjct: 30607 ATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAM-TWFHG 30665

Query: 1298  GRWLQEGPAASLSFL----------VATRAHAGAYSCQAQDAQGT 1332
              + LQ     ++             V  + HAG Y  Q  +  GT
Sbjct: 30666 QKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGT 30710



 Score = 38.5 bits (88), Expect = 0.057
 Identities = 78/325 (24%), Positives = 111/325 (34%), Gaps = 54/325 (16%)

Query: 252  ILPGELVTLTCQVNSSYPAVSSIKWLKDGVR-----------LQTKTGVLHLPQAAWSDA 300
            IL G  VT  C++ S YP +  I W KDG R           LQ     L +P     D 
Sbjct: 1302 ILEGMGVTFHCKM-SGYP-LPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDE 1359

Query: 301  GVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSW 360
            G+YT  A N  G+         I   ++ V PA P L   T        +   S    S 
Sbjct: 1360 GIYTAFASNIKGNA--------ICSGKLYVEPAAP-LGAPTYIPTLEPVSRIRSLSPRSV 1410

Query: 361  YKNHVLLEDAHSHTLRLHLA----TRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPV 416
             ++ + +  A     R+  A     R   G    E           PV V      L PV
Sbjct: 1411 SRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQLERLYKPVFV------LKPV 1464

Query: 417  LTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP--RFSGTSGPNSL 474
                LE Q     +    VV  P+      H G  + +   D  H    +  GT      
Sbjct: 1465 SFKCLEGQTARFDL---KVVGRPMPETFWFHDGQQIVN---DYTHKVVIKEDGTQS---- 1514

Query: 475  RLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA-------AEVVEGQAV 527
             L I     +DSGE+   A N  G ++ ++     A    + P          + EG  +
Sbjct: 1515 -LIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRL 1573

Query: 528  TLSCRSGLSPTPDARFSWYLNGALL 552
             +  R+  +P PD    W  N  ++
Sbjct: 1574 EMKVRATGNPNPD--IVWLKNSDII 1596



 Score = 37.7 bits (86), Expect = 0.096
 Identities = 70/362 (19%), Positives = 130/362 (35%), Gaps = 49/362 (13%)

Query: 1299  RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQG-TRSSRPAALQVLYAPQDAVLSSFRDS 1357
             R+   G   +L+   A+    G  +C ++  +G  +      L    +   A +S  R  
Sbjct: 33084 RYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQ 33143

Query: 1358  RARS--MAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQD 1415
                     +  C +  EP  E+    +   ++ SS V         +  +RN   L++++
Sbjct: 33144 NINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVS--------ISRSRNVYSLEIRN 33195

Query: 1416  VPAGDD-TYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVP---------EGAALNLSC 1465
                 D   Y   A+N  G  S    L V    +V EP  +V          +G+  + S 
Sbjct: 33196 ASVSDSGKYTIKAKNFRGQCSATASLMV--LPLVEEPSREVVLRTSGDTSLQGSFSSQSV 33253

Query: 1466  RLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHV-ARAQAGMYHCLAELPTGA----- 1519
             ++         S+F+         A  +  + F  + A++ + M     E+ + +     
Sbjct: 33254 QMSASKQEASFSSFS------SSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGIS 33307

Query: 1520  -----AASAPVMLRVLY---PPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSR 1571
                   +S   ML+      PPK   +   +  + G    + C    EP   +T   G R
Sbjct: 33308 NMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGR 33367

Query: 1572  LVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
              +  SQ QG       H+  + +   + I  ++  D G Y  S  N  GS S +    +R
Sbjct: 33368 KI-HSQEQG-----RFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 33421

Query: 1632  AL 1633
             ++
Sbjct: 33422 SI 33423



 Score = 37.7 bits (86), Expect = 0.096
 Identities = 62/317 (19%), Positives = 121/317 (38%), Gaps = 42/317 (13%)

Query: 1226  LELRGPQPRDEGFYSCSARSPLGQANTSLELRL-----EGVRVILAPEAA-VPEGAPITV 1279
             L ++    RDEG  +C +++  G      +L L     +    I  P +  + EG  +  
Sbjct: 33094 LTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLF 33153

Query: 1280  TCADPAAHAPTLYTWYHNGRWLQEGPAASLS---------FLVATRAHAGAYSCQAQDAQ 1330
             TC      +P +  W+ N   +      S+S            A+ + +G Y+ +A++ +
Sbjct: 33154 TCEISGEPSPEI-EWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFR 33212

Query: 1331  GTRSSRPAALQVL----YAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVL 1386
             G + S  A+L VL       ++ VL +  D+  +     Q    S    E + S      
Sbjct: 33213 G-QCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSS 33271

Query: 1387  ATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGA- 1445
             A+S      AS +     + ++++    ++ +     +     L  S S + +  + G  
Sbjct: 33272 ASSMTEMKFASMSAQ---SMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIP 33328

Query: 1446  -RVVAEPG-LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA-----------EP 1492
              ++ A P  + + EG  L ++C   G P P       W    R++H+           + 
Sbjct: 33329 PKIEALPSDISIDEGKVLTVACAFTGEPTP----EVTWSCGGRKIHSQEQGRFHIENTDD 33384

Query: 1493  VPTLAFTHVARAQAGMY 1509
             + TL    V +   G+Y
Sbjct: 33385 LTTLIIMDVQKQDGGLY 33401



 Score = 37.4 bits (85), Expect = 0.13
 Identities = 62/269 (23%), Positives = 91/269 (33%), Gaps = 49/269 (18%)

Query: 1225 RLELRGPQ--PRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCA 1282
            R  LR P   P DEG Y+  A +  G A  S +L +         E A P GAP  +   
Sbjct: 1346 RASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYV---------EPAAPLGAPTYIPTL 1396

Query: 1283 DPAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTR--SSRPAAL 1340
            +P +   +L     + R +   P       ++    + A    A+ + G R   +  + L
Sbjct: 1397 EPVSRIRSL-----SPRSVSRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQL 1451

Query: 1341 QVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDG---------KVLATSSG 1391
            + LY P   +            A     V   P  E    HDG         KV+    G
Sbjct: 1452 ERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDG 1511

Query: 1392 VHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEP 1451
              SL               + V   P+    +   AQN  G  S    L VE      +P
Sbjct: 1512 TQSL---------------IIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKP 1556

Query: 1452 -------GLDVPEGAALNLSCRLLGGPGP 1473
                    +++ EG+ L +  R  G P P
Sbjct: 1557 MFVEKLKNVNIKEGSRLEMKVRATGNPNP 1585



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 30/122 (24%), Positives = 51/122 (41%), Gaps = 15/122 (12%)

Query: 849  RFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE 908
            +F+   + +   L V+   L D G+YR      + S+  ++   +  AW +      L+E
Sbjct: 8702 KFEISIDGDRHTLRVKNCQLKDQGNYRLVCGPHIASAKLTV---IEPAWERHLQDVTLKE 8758

Query: 909  GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQ---------ESTSATLRFAAITLTQAGAYH 959
            GQ   ++CQ    VP   S  W+R+G+ L+         E     L  A +     G Y 
Sbjct: 8759 GQTCTMTCQF--SVPNVKS-EWFRNGRILKPQGRHKTEVEHKVHKLTIADVRAEDQGQYT 8815

Query: 960  CQ 961
            C+
Sbjct: 8816 CK 8817



 Score = 36.2 bits (82), Expect = 0.28
 Identities = 61/294 (20%), Positives = 103/294 (35%), Gaps = 49/294 (16%)

Query: 286   KTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGP-----ILENQ 340
             K  +L +  + + D GVYT + E           S  +F+  +++    P     + E +
Sbjct: 11537 KKHILVINDSQFDDEGVYTAEVEG-------KKTSARLFVTGIRLKFMSPLEDQTVKEGE 11589

Query: 341   TVTLVCNTPNEAPSDLRYSWYKNHVLLE---------DAHSHTLRLHLATRADTGFYFCE 391
             T T VC   +E    +   W+KN   L          +  +H L +   T  D      +
Sbjct: 11590 TATFVCELSHEK---MHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQ 11646

Query: 392   VQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHI 451
             V+ +  + +   + V+   P  T  L      +   +  L C V S+ +       G  I
Sbjct: 11647 VKELSSTAQ---LKVLEADPYFTVKLHDKTAVEKDEI-TLKCEV-SKDVPVKWFKDGEEI 11701

Query: 452   LASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAA 511
             + S        P++S  +      L+I+  +  D GEY C        A  T++     A
Sbjct: 11702 VPS--------PKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVE-----A 11748

Query: 512   RLLISP----AAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLL 561
             RL+         EV  G+             PD    W L G  L   P   ++
Sbjct: 11749 RLIKVEKPLYGVEVFVGETAHFEIELS---EPDVHGQWKLKGQPLTASPDCEII 11799



 Score = 36.2 bits (82), Expect = 0.28
 Identities = 43/209 (20%), Positives = 79/209 (37%), Gaps = 32/209 (15%)

Query: 718   TLQEGTEANLTCNVSREAAGSPA-NFSWFRNGV---------LWAQGPLETVTLLPVART 767
             T + G  A L+C +     G P  +  W+R G          + + G   T+T++   + 
Sbjct: 30543 TTKLGEAAQLSCQI----VGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQE 30598

Query: 768   DAALYACRILTEAG-AQLSTPVLLSVL--YPPDRPKLSALLDMGQGHMALFICTVDSRPL 824
             D  +Y C    E G  + S+ +LL     + P  P            + L +  +  RP+
Sbjct: 30599 DEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYI-GRPV 30657

Query: 825   ALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGS 884
               +  FHG+ LL  S    + +   +      N  +          +G Y+ + +NV G+
Sbjct: 30658 PAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKT-------HAGKYKVQLSNVFGT 30710

Query: 885   SNTSLFFQVRGAWVQVSPSPELQEGQAVV 913
              +  L        V++   P+   G  V+
Sbjct: 30711 VDAILD-------VEIQDKPDKPTGPIVI 30732



 Score = 36.2 bits (82), Expect = 0.28
 Identities = 32/148 (21%), Positives = 59/148 (39%), Gaps = 12/148 (8%)

Query: 362   KNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFL 421
             + + +  D  +HTL +    + D G Y C   N  G   +    ++   P   P      
Sbjct: 30577 RKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGY-PLK 30635

Query: 422   ETQAGLVGI---LHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEI 478
             E   G VG    LH   +  P+  +   HG  +L        +S   +  +  +   L +
Sbjct: 30636 EKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLL-------QNSENITIENTEHYTHLVM 30688

Query: 479   RDLE-ETDSGEYKCSATNSLGNATSTLD 505
             ++++ +T +G+YK   +N  G   + LD
Sbjct: 30689 KNVQRKTHAGKYKVQLSNVFGTVDAILD 30716



 Score = 35.8 bits (81), Expect = 0.37
 Identities = 57/231 (24%), Positives = 81/231 (35%), Gaps = 23/231 (9%)

Query: 672  LRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNV 731
            LR+ +  P  E+EG+Y   ASN  GNA  S         L + P+  L   T       V
Sbjct: 1349 LRIPVVLP--EDEGIYTAFASNIKGNAICSGK-------LYVEPAAPLGAPTYIPTLEPV 1399

Query: 732  SREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLS 791
            SR  + SP + S  R+ +  +   +    + P   + A +   R L E          L 
Sbjct: 1400 SRIRSLSPRSVS--RSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDES-----QLE 1452

Query: 792  VLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQ 851
             LY P            +G  A F   V  RP+     FH    +      +V       
Sbjct: 1453 RLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKV------- 1505

Query: 852  AKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSP 902
               E  +  L +      DSG +   A N  G S+ S+   V     QV P
Sbjct: 1506 VIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKP 1556



 Score = 35.8 bits (81), Expect = 0.37
 Identities = 41/171 (23%), Positives = 67/171 (39%), Gaps = 34/171 (19%)

Query: 255   GELVTLTCQVNSSYPAVSSIKWLKDGVRL----------QTKTGVLHLPQAAWSDAGVYT 304
             GE   L+CQ+      +  IKW + G  L            +T  L +      D GVYT
Sbjct: 30547 GEAAQLSCQIVGR--PLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYT 30604

Query: 305   CQAENGVGSLVSPPISLHIFMAEVQVSPAGPILE------NQTVTL-VCNTPNEAPSDLR 357
             C A N VG + +   S  +  A  Q  P  P+ E        T+ L V       P+   
Sbjct: 30605 CIATNEVGEVETS--SKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPA--- 30659

Query: 358   YSWYKNHVLLEDA----------HSHTLRLHLATRADTGFYFCEVQNVHGS 398
              +W+    LL+++          ++H +  ++  +   G Y  ++ NV G+
Sbjct: 30660 MTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGT 30710



 Score = 34.7 bits (78), Expect = 0.82
 Identities = 32/128 (25%), Positives = 50/128 (39%), Gaps = 25/128 (19%)

Query: 408   VNHPPLT--PVLTAFLETQAGL-VGILHCSVVSEPLATLV---------LSHGGHILAST 455
             V H P++  P +T FL+ +A   +  L C V S  L             L   GH     
Sbjct: 32709 VQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHY 32768

Query: 456   SGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLI 515
             S D  +              L+I +L E+D GEY C  +   G + + L F   A + + 
Sbjct: 32769 SADGTYE-------------LKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIH 32815

Query: 516   SPAAEVVE 523
                +++ E
Sbjct: 32816 EKVSKISE 32823



 Score = 33.9 bits (76), Expect = 1.4
 Identities = 25/113 (22%), Positives = 48/113 (42%), Gaps = 9/113 (7%)

Query: 782  AQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLG 841
            A++  PV + V  PP        + + +G      C +   P   +  +  ++ + +S+ 
Sbjct: 930  ARVPAPVEIPVT-PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSID 988

Query: 842  PQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894
                    FQ   ++   +L +RE    DSG + C A N  G+ +TS +  V+
Sbjct: 989  --------FQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 1033



 Score = 33.9 bits (76), Expect = 1.4
 Identities = 26/90 (28%), Positives = 49/90 (54%), Gaps = 18/90 (20%)

Query: 252  ILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQT--------KTGV--LHLPQAAWSDAG 301
            ++ GE VTL C + S YP+  ++ W ++  ++++        ++G+  L + +A   D+G
Sbjct: 954  VIEGESVTLECHI-SGYPS-PTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSG 1011

Query: 302  VYTCQAENGVGSLVSPPISLHIFMAEVQVS 331
             +TC A N  G+     +S   ++A VQVS
Sbjct: 1012 RFTCSAVNEAGT-----VSTSCYLA-VQVS 1035



 Score = 33.9 bits (76), Expect = 1.4
 Identities = 22/74 (29%), Positives = 32/74 (43%), Gaps = 13/74 (17%)

Query: 273   SIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLH 322
             +I W+KDG  L+  T V          LH+ +    D G YT  A N  G+      +L 
Sbjct: 24342 NISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATE---NLS 24398

Query: 323   IFMAEVQVSPAGPI 336
             + + E    P GP+
Sbjct: 24399 VIVLEKPGPPVGPV 24412



 Score = 33.9 bits (76), Expect = 1.4
 Identities = 47/218 (21%), Positives = 74/218 (33%), Gaps = 33/218 (15%)

Query: 1070  SNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL 1129
             ++T+       +F     N   + G  VR G  +       T HP +   TWY+ GQ+  
Sbjct: 31680 TDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTI-------TVHP-EPHVTWYKSGQKIK 31731

Query: 1130  DA--------------HSIPLPNVTVRDATSY----RCGVGPPGRAPRLS---RPITLDV 1168
                             + + + +VT  D   Y    R   G      +L+    P   D 
Sbjct: 31732 PGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDS 31791

Query: 1169  LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT----L 1224
                P   RL    E   GQ       V   PP  L     G+ L+      + +      
Sbjct: 31792 TLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYY 31851

Query: 1225  RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVR 1262
              L +R   P D G+Y  +A +  G  +    L++E +R
Sbjct: 31852 ALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVERLR 31889



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 30/119 (25%), Positives = 46/119 (38%), Gaps = 9/119 (7%)

Query: 1513 AELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRL 1572
            A++   A   APV + V  PP   + +  V    G    L+C +   P  ++T +     
Sbjct: 924  AKVTETARVPAPVEIPVT-PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQ 982

Query: 1573 VASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
            + SS            +       R+ I      D G + CSA N  G+ STS Y  V+
Sbjct: 983  IESSID--------FQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 1033



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 38/171 (22%), Positives = 68/171 (39%), Gaps = 35/171 (20%)

Query: 272   SSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISL 321
             +++ W KDG  L+  T V          L + +A+  D G Y     N  GS ++ PI++
Sbjct: 25424 ATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGS-ITVPITI 25482

Query: 322   HIFMAEVQVSPAGPI----LENQTVTLVCNTPN------------EAPSDLRYSWYKNHV 365
              +     +  P GPI    +   ++T+  N P             E       +W   H+
Sbjct: 25483 IVL---DRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTW---HI 25536

Query: 366   LLEDAHSHTLRL-HLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTP 415
             + +     ++++  L T ++  F  C  +N +G       S VV   P +P
Sbjct: 25537 VSQAVARTSIKIVRLTTGSEYQFRVC-AENRYGKSSYSESSAVVAEYPFSP 25586



 Score = 32.7 bits (73), Expect = 3.1
 Identities = 43/195 (22%), Positives = 74/195 (37%), Gaps = 22/195 (11%)

Query: 767   TDAALYACRILTE----AGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSR 822
             T+ A+Y  R++ E     G  + T   +    PP  P    L D+ Q   +L     +  
Sbjct: 24180 TEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEHD 24239

Query: 823   PLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVL 882
                      G  +L   +  Q     ++   AE+      V  L  G    +R +A N  
Sbjct: 24240 G--------GSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEK 24291

Query: 883   GSSNTSLF-FQVRGAWVQVSPSPEL-------QEGQAVVLSCQVHTGVPEGTSYRWYRDG 934
             G S+  +    V    + + PS +L       Q G+ + +   V  G P   +  W +DG
Sbjct: 24292 GKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPV-IGRPR-PNISWVKDG 24349

Query: 935   QPLQESTSATLRFAA 949
             +PL+++T   +   A
Sbjct: 24350 EPLKQTTRVNVEETA 24364



 Score = 32.7 bits (73), Expect = 3.1
 Identities = 38/149 (25%), Positives = 56/149 (37%), Gaps = 16/149 (10%)

Query: 362   KNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPP-----LTPV 416
             K +    D   + L ++  T  D   Y    +N +G +       V  HPP     L P+
Sbjct: 31737 KKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPM 31796

Query: 417   ---LTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILA-STSGDSDHSPRFSGTSGPN 472
                L A  E Q G        V   P  TL     G  L+   + +  H        G +
Sbjct: 31797 FKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHE-------GLD 31849

Query: 473   SLRLEIRDLEETDSGEYKCSATNSLGNAT 501
                L IRD    D+G Y+ +ATN+ G+ +
Sbjct: 31850 YYALHIRDTLPEDTGYYRVTATNTAGSTS 31878



 Score = 32.7 bits (73), Expect = 3.1
 Identities = 27/74 (36%), Positives = 36/74 (48%), Gaps = 9/74 (12%)

Query: 434   SVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSA 493
             +V S+P A +   H G  L  +S        ++ TSG   L LEI D    DSG Y+   
Sbjct: 32396 NVQSKPTAEVKWYHNGVELQESS-----KIHYTNTSGV--LTLEILDCHTDDSGTYRAVC 32448

Query: 494   TNSLGNAT--STLD 505
             TN  G A+  +TLD
Sbjct: 32449 TNYKGEASDYATLD 32462



 Score = 32.3 bits (72), Expect = 4.1
 Identities = 23/86 (26%), Positives = 35/86 (40%), Gaps = 2/86 (2%)

Query: 472  NSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLI--SPAAEVVEGQAVTL 529
            N   L IRD+   DS      A N  G  +S       A +L+       +VV  +  T+
Sbjct: 2132 NVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTM 2191

Query: 530  SCRSGLSPTPDARFSWYLNGALLHEG 555
            +     +  P  +  WY +G  +HEG
Sbjct: 2192 ATFECETSEPFVKVKWYKDGMEVHEG 2217



 Score = 32.3 bits (72), Expect = 4.1
 Identities = 24/100 (24%), Positives = 43/100 (43%), Gaps = 13/100 (13%)

Query: 849   RFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQV-----------RGAW 897
             ++  +++    +L +  +   D   Y   A N  G  +      V           R  +
Sbjct: 31738 KYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMF 31797

Query: 898   VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL 937
              ++  + E QEGQ+V    +V +G+P  T  +W +DGQPL
Sbjct: 31798 KRLLANAECQEGQSVCFEIRV-SGIPPPT-LKWEKDGQPL 31835



 Score = 32.3 bits (72), Expect = 4.1
 Identities = 27/118 (22%), Positives = 53/118 (44%), Gaps = 12/118 (10%)

Query: 1332  TRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDS--EPPAELALSHDGKVLATS 1389
             TR + P A + + + +  +++  +D+   S +V +  V +  EP      + DGK + T 
Sbjct: 32837 TRKTEPKAPEPI-SSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAI-TQ 32894

Query: 1390  SGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQVEGAR 1446
              G + L+   G          L++      D   Y CT +N  GS+S+  +L ++  +
Sbjct: 32895 GGKYKLSEDKG-------GFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIK 32945



 Score = 32.0 bits (71), Expect = 5.3
 Identities = 32/156 (20%), Positives = 60/156 (38%), Gaps = 15/156 (9%)

Query: 48   DVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQP 107
            DV + +G T      +S          + ++++ + R +TE     EH+V  L + D++ 
Sbjct: 8753 DVTLKEGQTCTMTCQFSVPNVKSEWFRNGRILKPQGRHKTEV----EHKVHKLTIADVRA 8808

Query: 108  EDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCL 167
            ED G Y  ++E  E +    ++   +  T+  R+  I     + E     F C   +   
Sbjct: 8809 EDQGQYTCKYEDLETSAELRIEAEPIQFTK--RIQNIV----VSEHQSATFECEVSF--- 8859

Query: 168  QEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLH 203
             +   + W  + P          F   G  H  T+H
Sbjct: 8860 -DDAIVTWY-KGPTELTESQKYNFRNDGRCHYMTIH 8893



 Score = 32.0 bits (71), Expect = 5.3
 Identities = 38/158 (24%), Positives = 58/158 (36%), Gaps = 13/158 (8%)

Query: 1473  PVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVML----- 1527
             P G    AW    R+ +   V  L FT     + G Y    +    A  S P        
Sbjct: 16055 PTGTKKEAW----RQCNKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCD 16110

Query: 1528  --RVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEP 1585
               R   PP    +  F+E E G    +  ++   P  +LT          ++ +    + 
Sbjct: 16111 CQRPDMPPSID-LKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNK-EPVLYDT 16168

Query: 1586  HIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSAS 1623
             H++ L   +   + I   R SD G Y  +A N LG+AS
Sbjct: 16169 HVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTAS 16206



 Score = 32.0 bits (71), Expect = 5.3
 Identities = 17/40 (42%), Positives = 23/40 (57%), Gaps = 1/40 (2%)

Query: 1060  EDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVRE 1099
             EDEGVY C A+N +G+   S+    QA   Q  PG  ++E
Sbjct: 30598 EDEGVYTCIATNEVGEVETSSKLLLQA-TPQFHPGYPLKE 30636



 Score = 31.2 bits (69), Expect = 9.0
 Identities = 16/53 (30%), Positives = 27/53 (50%), Gaps = 10/53 (18%)

Query: 271   VSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTCQAENGVGS 313
             V ++ W KDG  ++    +          L +P++  +DAG+YT   EN +GS
Sbjct: 14415 VPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGS 14467



 Score = 31.2 bits (69), Expect = 9.0
 Identities = 21/81 (25%), Positives = 33/81 (40%), Gaps = 7/81 (8%)

Query: 423   TQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLE 482
             T+ G    L C +V  PL  +     G  L         S ++  +S   +  L +   E
Sbjct: 30544 TKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ-------SRKYKMSSDGRTHTLTVMTEE 30596

Query: 483   ETDSGEYKCSATNSLGNATST 503
             + D G Y C ATN +G   ++
Sbjct: 30597 QEDEGVYTCIATNEVGEVETS 30617


>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
          Length = 4391

 Score =  185 bits (470), Expect = 3e-46
 Identities = 415/1794 (23%), Positives = 636/1794 (35%), Gaps = 327/1794 (18%)

Query: 18   QASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSADPK 77
            Q   G      VQG  G CL  P     P  VEV    + +        R  VS S    
Sbjct: 1652 QCGPGYVGNPSVQG--GQCL--PETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHY 1707

Query: 78   LVEARFRGRTEFMGNPE-HRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVT 136
               +R  GR    G  + H+   L    +QP D+G Y         +  S  +   + VT
Sbjct: 1708 FYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAE---LLVT 1764

Query: 137  EEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQ----VRLQW----QGQDPARSVTFNS 188
            E P  P I   VE      V       ++C  +       L W     G+ P R++ FN 
Sbjct: 1765 EAPSKP-ITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFN- 1822

Query: 189  QKFEPTGVGHLETLHMAMSWQDHGRILRCQLSV-ANHRAQSEIHLQVKYAPKGVKILLSP 247
                    G L   ++ +S  D G  +    ++ A  +  + +H+Q         + + P
Sbjct: 1823 --------GILTIRNVQLS--DAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHP 1872

Query: 248  SGRNILPGELVTLTCQVNSSYPAVSSIKWL-KDGVRLQTKT----GVLHLPQAAWSDAGV 302
                + PG+L    C    S     +++W    G +L  K     G+L LP    +D   
Sbjct: 1873 PQLTVQPGQLAEFRCSATGS--PTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQ 1930

Query: 303  YTCQAENGVGSLVSPPISLHIFMA---EVQVSP-AGPILENQTVTLVCNTPNEAPSDLRY 358
            Y C+A +  G  V+  + LH+       VQVSP    +   +TV L C       + +  
Sbjct: 1931 YLCRAHSSAGQQVARAV-LHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATI-- 1987

Query: 359  SWYKNHVLL------EDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVN--- 409
            +W K    L      E     TL +   T AD GFY C   +  G+ ++    VV++   
Sbjct: 1988 TWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASD 2047

Query: 410  -HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGT 468
              PP   + ++      G    L+C V     A +     G  L          P  +  
Sbjct: 2048 ASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSL----------PPHTQV 2097

Query: 469  SGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD---FHANAARLLISP-------- 517
             G    RL +  +   DSGEY C   N  G   +++     H   +    +P        
Sbjct: 2098 HGS---RLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPI 2154

Query: 518  -----AAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALL---HEGPGSSLLLPAASSTD 569
                 ++ V EGQ + L+C   +     A+ +W+  G  L   H+  GS L L   +  D
Sbjct: 2155 RIEPSSSHVAEGQTLDLNC--VVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPAD 2212

Query: 570  AGSYHCRARDGHSASGPSSPAVLTVLYPP--RQPTFTTRLDLDAAGAGAGRRGLLLCRVD 627
            +G Y C        SGP   +VL  +       P    R++  ++    G+   L C V 
Sbjct: 2213 SGEYVCHV---VGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVA 2269

Query: 628  SDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLY 687
                A++    +                 GG  P     +     R+ I      + G Y
Sbjct: 2270 GQAHAQVTWYKR-----------------GGSLPARHQVRGS---RLYIFQASPADAGQY 2309

Query: 688  LCEASNALGNASTSATFNGQATVLA----------IAPSHT-LQEGTEANLTCNVSREAA 736
            +C ASN +  + T      Q   LA          I PS + + EG   +L C V  +  
Sbjct: 2310 VCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQ-- 2367

Query: 737  GSPANFSWFRNG---VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVL 793
             S A  +W + G    +  Q     + L   +  D+  Y CR+L  +   L   VL+++ 
Sbjct: 2368 -SHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVL-GSSVPLEASVLVTIE 2425

Query: 794  YPPDRPKL----SALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSH-- 847
                 P L    +  ++     +A      + + L L  L  G+         QV  H  
Sbjct: 2426 PAGSVPALGVTPTVRIESSSSQVA------EGQTLDLNCLVAGQ------AHAQVTWHKR 2473

Query: 848  -GRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR----GAWVQ--- 899
             G   A+ + +  +L + ++   DSG Y C      G+   S+   ++    G+  Q   
Sbjct: 2474 GGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVA 2533

Query: 900  -----VSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL---QESTSATLRFAAIT 951
                  S S  L  G  + L+C V +  P   +  WY+ G  L    +   + LR   +T
Sbjct: 2534 YPVRIESSSASLANGHTLDLNCLVASQAPH--TITWYKRGGSLPSRHQIVGSRLRIPQVT 2591

Query: 952  LTQAGAYHCQ-AQAPGSATTSLAAPI----SLHVSYAPRHVTLTTLMDT-GPGRLGLLLC 1005
               +G Y C  +   GS  TSL   I    S HV      + + +   T   G+   L C
Sbjct: 2592 PADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNC 2651

Query: 1006 RVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVY 1065
             V   P A         ++    +G     GS P  H     +   L +H   + D G Y
Sbjct: 2652 VVARQPQA---------IITWYKRG-----GSLPSRH---QTHGSHLRLHQMSVADSGEY 2694

Query: 1066 ICEASNTLGQASASADFD-AQAVNVQVWPGAT-----------VREGQLVNLTCLVWTTH 1113
            +C A+N +    AS     + +      PG++           V EG+ ++L C+V    
Sbjct: 2695 VCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQA 2754

Query: 1114 PAQLTYTWYQDGQQRLDAHS-----IPLPNVTVRDATSYRCGV----GP----------- 1153
             AQ+  TW++ G      H      + L +V+  D+  Y C V    GP           
Sbjct: 2755 HAQV--TWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEA 2812

Query: 1154 ----------PGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQL 1203
                      PG AP    PI ++    P + R+        GQ   + C V  +  AQ+
Sbjct: 2813 SGSSAVHVPAPGGAP----PIRIE----PSSSRVA------EGQTLDLKCVVPGQAHAQV 2858

Query: 1204 ALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE--GV 1261
                 G  L +      P    L L    P D G YSC      G    S+ + +E    
Sbjct: 2859 TWHKRGGNLPARHQVHGP---LLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSP 2915

Query: 1262 RVILAPEAAVP-----------EGAPITVTCADPA-AHAPTLYTWYHNGRWL---QEGPA 1306
              I AP  A P           EG  + + C  P  AHA    TWY  G  L    +   
Sbjct: 2916 GPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQV--TWYKRGGSLPARHQTHG 2973

Query: 1307 ASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR-DSRARSMAVI 1365
            + L   + + A +G Y C+A  A G    + A+  V   P +   SS+R  S   S+   
Sbjct: 2974 SQLRLHLVSPADSGEYVCRA--ASGPGPEQEASFTVTVPPSEG--SSYRLRSPVISIDPP 3029

Query: 1366 QCTVDSEPPAEL-ALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV-PAGDDTY 1423
              TV     A    L HDG    +            +V ++ N   + +    P+   TY
Sbjct: 3030 SSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTY 3089

Query: 1424 VCTAQNLLGSISTIGRLQVEG---ARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFA 1480
             C A N  G   ++  L V G     V+ E  + V  G A+ L C   G P     S+  
Sbjct: 3090 RCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEP----RSSAR 3145

Query: 1481 WFWNDRRLHAEPV-------------PTLAFTHVARAQAGMYHCLAELPTGAAASAPVML 1527
            W     R+ + P                L  +    + AG Y CLA+   G A       
Sbjct: 3146 W----TRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQK----- 3196

Query: 1528 RVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHI 1587
                      + V V+      G    + +    A LT+  G          G+PA P I
Sbjct: 3197 ---------QVEVIVDTGAMAPGAPQVQAEE---AELTVEAGHTATLRCSATGSPA-PTI 3243

Query: 1588 H--VLASP----NALRVD---IEALRPSDQGEYICSASNVLGSASTSTYFGVRA 1632
            H   L SP    + L  D   I  +   D G+YIC+A++  G A  +    V +
Sbjct: 3244 HWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVES 3297



 Score =  184 bits (466), Expect = 8e-46
 Identities = 374/1696 (22%), Positives = 593/1696 (34%), Gaps = 304/1696 (17%)

Query: 100  LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEE----PRVPTIASPVEL----- 150
            L L  + P DSG Y  R E     + + +  +++  T        VP    P+ +     
Sbjct: 2102 LRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSS 2161

Query: 151  --LEGTEVDFNCSTPYVCLQEQVRLQWQ---GQDPARSVTFNSQKFEPTGVGHLETLHMA 205
               EG  +D NC  P    Q   ++ W    G  PAR  T           G L  LH  
Sbjct: 2162 HVAEGQTLDLNCVVPG---QAHAQVTWHKRGGSLPARHQTH----------GSLLRLHQV 2208

Query: 206  MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVK-ILLSPSGRNILPGELVTLTCQV 264
                    +     +     A   + ++    P  +  + +  S   +  G+ + L+C V
Sbjct: 2209 TPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVV 2268

Query: 265  NSSYPAVSSIKWLKDG----VRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPIS 320
                 A + + W K G     R Q +   L++ QA+ +DAG Y C+A NG+ + ++  ++
Sbjct: 2269 AGQ--AHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVT 2326

Query: 321  ----LHIFMAEVQVSP------AGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLL--- 367
                 ++        P      +  + E QT+ L C  P +  S  + +W+K    L   
Sbjct: 2327 GTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQ--SHAQVTWHKRGGSLPVR 2384

Query: 368  EDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL--TPVL----TAFL 421
               H   LRL+ A+ AD+G Y C V    GS      SV+V   P    P L    T  +
Sbjct: 2385 HQTHGSLLRLYQASPADSGEYVCRVL---GSSVPLEASVLVTIEPAGSVPALGVTPTVRI 2441

Query: 422  ETQAGLVGI-----LHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRL 476
            E+ +  V       L+C V  +  A +     G  L +      H    S        RL
Sbjct: 2442 ESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPAR-----HQVHGS--------RL 2488

Query: 477  EIRDLEETDSGEYKCSATNSLGNATSTL---------DFHANAARLLI---SPAAEVVEG 524
             +  +   DSGEY C    S G   +++           H+      +   S +A +  G
Sbjct: 2489 RLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANG 2548

Query: 525  QAVTLSCRSGLSPTPDARFSWYLNGALL---HEGPGSSLLLPAASSTDAGSYHCRARDGH 581
              + L+C    S  P    +WY  G  L   H+  GS L +P  +  D+G Y C   +G 
Sbjct: 2549 HTLDLNCLVA-SQAPHT-ITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGA 2606

Query: 582  SASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGA--GRRGLLLCRVDSDPPARLQLLHK 639
             +   S    +        P+ +  + ++++      G+   L C V   P A +    +
Sbjct: 2607 GSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKR 2666

Query: 640  DRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNAS 699
                             GG  P    T   +L    +H   + + G Y+C A+N +    
Sbjct: 2667 -----------------GGSLPSRHQTHGSHL---RLHQMSVADSGEYVCRANNNIDALE 2706

Query: 700  TSATFN-----------GQATVLAIAPSHT-LQEGTEANLTCNVSREAAGSPANFSWFRN 747
             S   +           G +  + I  S + + EG   +L C V  +A    A  +W + 
Sbjct: 2707 ASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAH---AQVTWHKR 2763

Query: 748  GVLWA---QGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSAL 804
            G       Q     + L  V+  D+  Y CR++  +G     P+  SVL   +    SA+
Sbjct: 2764 GGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSG-----PLEASVLVTIEASGSSAV 2818

Query: 805  LDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSH---GRFQAKAEANSLKL 861
                 G          S  +A       + ++      QV  H   G   A+ + +   L
Sbjct: 2819 HVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLL 2878

Query: 862  EVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQ-------------E 908
             + ++   DSG Y C+ T   G+   S+   +  +     P+P L              E
Sbjct: 2879 RLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTE 2938

Query: 909  GQAVVLSC----QVHTGVPEGTSYRWYRDGQPL---QESTSATLRFAAITLTQAGAYHCQ 961
            GQ + L+C    Q H  V       WY+ G  L    ++  + LR   ++   +G Y C+
Sbjct: 2939 GQTLDLNCVVPGQAHAQVT------WYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCR 2992

Query: 962  AQA-PG---SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRL 1017
            A + PG    A+ ++  P S   SY  R   ++    +           V     A  + 
Sbjct: 2993 AASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSST---------VQQGQDASFKC 3043

Query: 1018 LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQAS 1077
            L  D     +L+     +     +H++  PN   + I G    + G Y C ASN  G A 
Sbjct: 3044 LIHDGAAPISLEWKTRNQELEDNVHIS--PNGSIITIVGTRPSNHGTYRCVASNAYGVAQ 3101

Query: 1078 ASADFDAQAV-NVQVWPGATV--REGQLVNLTCLV---------WT---THPAQLTYTWY 1122
            +  +        V V P   V  + G+ V L C+          WT   + PA+L    Y
Sbjct: 3102 SVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTY 3161

Query: 1123 QDGQQRLDAHSI-PLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYL 1180
                  +D+H++  + +    DA +Y C      G A +    I      AP   ++   
Sbjct: 3162 G----LMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV--- 3214

Query: 1181 LESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQP------- 1233
                  Q      TV++         H   L  S+T +  P     +LR P P       
Sbjct: 3215 ------QAEEAELTVEA--------GHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEG 3260

Query: 1234 ----------RDEGFYSCSARSPLGQANTSLELRLEG--VRVILAPEAAVPEGAPITVTC 1281
                      +D G Y C+A SP G A  ++ L +E       +   A+V  G  + + C
Sbjct: 3261 DTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQC 3320

Query: 1282 ADPAAHA--PTLYTWYHNGRWLQEGPAASLSFLVATRA---HAGAYSCQAQD-------- 1328
                AH   P  + W   G  L     A    L   RA    +G Y C+  +        
Sbjct: 3321 L---AHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAF 3377

Query: 1329 ----AQGTRSSRPA-ALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDG 1383
                 QG   S PA ++     P   V          +     C V S+   +L    +G
Sbjct: 3378 AQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEG 3437

Query: 1384 KVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVE 1443
              L      HS+  G          LR+Q  D      TY+C A    G      +L ++
Sbjct: 3438 GQLPPG---HSVQDGV---------LRIQNLDQSC-QGTYICQAHGPWGKAQASAQLVIQ 3484

Query: 1444 GARVVA----EPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPV-----P 1494
                V          V  G A+   C  LG P P         W+    H  P       
Sbjct: 3485 ALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVT------WSKVGGHLRPGIVQSGG 3538

Query: 1495 TLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDC 1554
             +   HV  A AG Y C A    G   S  ++L    P  +    V V    G   +  C
Sbjct: 3539 VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVP--AGSAAVFPC 3596

Query: 1555 RVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICS 1614
                 P   ++    S+L  S  P     E ++ +L S          +RP D G Y+C+
Sbjct: 3597 IASGYPTPDISW---SKLDGSLPPDSR-LENNMLMLPS----------VRPQDAGTYVCT 3642

Query: 1615 ASNVLGSASTSTYFGV 1630
            A+N  G      +  V
Sbjct: 3643 ATNRQGKVKAFAHLQV 3658



 Score =  181 bits (459), Expect = 5e-45
 Identities = 377/1594 (23%), Positives = 584/1594 (36%), Gaps = 327/1594 (20%)

Query: 226  AQSEIHLQVKYA----PKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGV 281
            AQ+ I + V  A    P  VKI    S  ++  G+ + L C V  S  A + + W + G 
Sbjct: 2034 AQARIQVVVLSASDASPPPVKI--ESSSPSVTEGQTLDLNCVVAGS--AHAQVTWYRRGG 2089

Query: 282  RLQTKTGV----LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGP-- 335
             L   T V    L LPQ + +D+G Y C+ ENG G     P    I ++ +  + +GP  
Sbjct: 2090 SLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSG-----PKEASITVSVLHGTHSGPSY 2144

Query: 336  ------------------ILENQTVTLVCNTPNEAPSDLRYSWYKNHVLL---EDAHSHT 374
                              + E QT+ L C  P +A + +  +W+K    L      H   
Sbjct: 2145 TPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQV--TWHKRGGSLPARHQTHGSL 2202

Query: 375  LRLHLATRADTGFYFCEVQNVHGS-ERSGPVSVVVNHPPLTPVLTAFLETQAGLVG---- 429
            LRLH  T AD+G Y C V    G  E S  V++  +  P  P+    +E+ +  V     
Sbjct: 2203 LRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIP-GPIPPVRIESSSSTVAEGQT 2261

Query: 430  -ILHCSVVSEPLATLV-LSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
              L C V  +  A +     GG + A       H  R S        RL I      D+G
Sbjct: 2262 LDLSCVVAGQAHAQVTWYKRGGSLPAR------HQVRGS--------RLYIFQASPADAG 2307

Query: 488  EYKCSATNSL---------GNATSTLDFHANAAR-LLISP-AAEVVEGQAVTLSCRSGLS 536
            +Y C A+N +         G   + L + A + + + I P +++V EGQ + L+C   + 
Sbjct: 2308 QYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNC--VVP 2365

Query: 537  PTPDARFSWYLNGALL---HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLT 593
                A+ +W+  G  L   H+  GS L L  AS  D+G Y CR      +S P   +VL 
Sbjct: 2366 GQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVL---GSSVPLEASVLV 2422

Query: 594  VLYPPRQ-----PTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLP 648
             + P         T T R++  ++    G+   L C V     A++   HK         
Sbjct: 2423 TIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQV-TWHKR-------- 2473

Query: 649  SGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQA 708
                    GG  P         L  +++      + G Y+C    + G    S     Q 
Sbjct: 2474 --------GGSLPARHQVHGSRLRLLQV---TPADSGEYVCRVVGSSGTQEASVLVTIQQ 2522

Query: 709  ------------TVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWF-RNGVLWAQGP 755
                         V   + S +L  G   +L C V+ +A   P   +W+ R G L ++  
Sbjct: 2523 RLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQA---PHTITWYKRGGSLPSRHQ 2579

Query: 756  L--ETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSV----------LYPPDRPKLSA 803
            +    + +  V   D+  Y C +   AG++  T +++++          + PP R + S+
Sbjct: 2580 IVGSRLRIPQVTPADSGEYVCHVSNGAGSR-ETSLIVTIQGSGSSHVPSVSPPIRIE-SS 2637

Query: 804  LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
               + +G      C V  +P A++  +          G  +PS      + + +   L +
Sbjct: 2638 SPTVVEGQTLDLNCVVARQPQAIITWY--------KRGGSLPS------RHQTHGSHLRL 2683

Query: 864  RELGLGDSGSYRCEATNVLGSSNTSLFFQVR---------GAWVQV---SPSPELQEGQA 911
             ++ + DSG Y C A N + +   S+   V          G+ + +   S S  + EG+ 
Sbjct: 2684 HQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGET 2743

Query: 912  VVLSC----QVHTGVPEGTSYRWYRDGQPL---QESTSATLRFAAITLTQAGAYHCQAQ- 963
            + L+C    Q H  V       W++ G  L    ++  + LR   ++   +G Y C+   
Sbjct: 2744 LDLNCVVPGQAHAQV------TWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMG 2797

Query: 964  APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRL 1023
            + G    S+   I    S A  HV         P   G    R++   P+  R+  G  L
Sbjct: 2798 SSGPLEASVLVTIEASGSSAV-HV---------PAPGGAPPIRIE---PSSSRVAEGQTL 2844

Query: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLE-------DEGVYICEASNTLGQA 1076
                +  V G   +    H        R ++HG +L        D G Y C+ + + G  
Sbjct: 2845 DLKCV--VPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTL 2902

Query: 1077 SAS--------------ADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWY 1122
             AS              A   AQ + ++    + V EGQ ++L C+V     AQ+  TWY
Sbjct: 2903 EASVLVTIEPSSPGPIPAPGLAQPIYIEA-SSSHVTEGQTLDLNCVVPGQAHAQV--TWY 2959

Query: 1123 QDG-----QQRLDAHSIPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLR 1176
            + G     + +     + L  V+  D+  Y C     PG     S  +T+     P +  
Sbjct: 2960 KRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTV-----PPSEG 3014

Query: 1177 LTYLLES------------HGGQLALVLCTV-DSRPPAQLALSHAGRLLASSTAASVPNT 1223
             +Y L S              GQ A   C + D   P  L      + L  +   S PN 
Sbjct: 3015 SSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHIS-PNG 3073

Query: 1224 LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG---VRVILAPEAAVPEGAPITVT 1280
              + + G +P + G Y C A +  G A + + L + G   V V+      V  G  +T+ 
Sbjct: 3074 SIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLE 3133

Query: 1281 CADPAAHAPTLYTWYHNGRW--LQEGPA-------------ASLSFLVATRAHAGAYSCQ 1325
            C   +A  P       + RW  +   PA             A L    A  + AG Y C 
Sbjct: 3134 CV--SAGEPR-----SSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCL 3186

Query: 1326 AQDAQGTRSSRPAAL-----QVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALS 1380
            AQ+A GT   +   +         APQ     +     A   A ++C+    P   +   
Sbjct: 3187 AQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTI--- 3243

Query: 1381 HDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRL 1440
            H  K+ +     H L   T  +       R+  QD       Y+C A +  G       L
Sbjct: 3244 HWSKLRSPLPWQHRLEGDTLIIP------RVAQQD----SGQYICNATSPAGHAEATIIL 3293

Query: 1441 QVEG---ARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLA 1497
             VE    A  V E    V  G  + L C   G P P+   TF W      L         
Sbjct: 3294 HVESPPYATTVPEHA-SVQAGETVQLQCLAHGTP-PL---TFQWSRVGSSLPGRATARNE 3348

Query: 1498 FTHVARA---QAGMYHCLAELPTGAAASAPVMLRVLYPP-----------KTPTMMVFVE 1543
              H  RA    +G Y C      G +A A   L V  PP            TPT+ V  +
Sbjct: 3349 LLHFERAAPEDSGRYRCRVTNKVG-SAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQ 3407

Query: 1544 PEG---GLRGILDCRVDSEPLASLT-LHLGSRLVASSQPQGAPAEPHIHVLASPNALRVD 1599
             E    G      C V S+    L     G +L     P G   +  +          + 
Sbjct: 3408 LETKSIGASVEFHCAVPSDRGTQLRWFKEGGQL-----PPGHSVQDGV----------LR 3452

Query: 1600 IEALRPSDQGEYICSASNVLGSASTSTYFGVRAL 1633
            I+ L  S QG YIC A    G A  S    ++AL
Sbjct: 3453 IQNLDQSCQGTYICQAHGPWGKAQASAQLVIQAL 3486



 Score =  156 bits (394), Expect = 2e-37
 Identities = 347/1569 (22%), Positives = 559/1569 (35%), Gaps = 307/1569 (19%)

Query: 243  ILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDG----VRLQTKTGVLHLPQAAWS 298
            I + PS  ++  G+ + L C V     A + + W K G     R QT   +L L Q   +
Sbjct: 2154 IRIEPSSSHVAEGQTLDLNCVVPGQ--AHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPA 2211

Query: 299  DAGVYTCQAENGVGSL-VSPPISLHIFMAEVQVSP------AGPILENQTVTLVCNTPNE 351
            D+G Y C      G L  S  +++   +    + P      +  + E QT+ L C    +
Sbjct: 2212 DSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQ 2271

Query: 352  APSDLRYSWYKNHVLLEDAHS---HTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVV 408
            A + +  +WYK    L   H      L +  A+ AD G Y C   N  G E S  V+V  
Sbjct: 2272 AHAQV--TWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASN--GMEASITVTV-- 2325

Query: 409  NHPPLTPVLTAFLETQAGLVGILHCSVVSEPLA-------TLVLSHGGHILASTSGDSDH 461
                 T    A L   AG    +     S  +A         V+    H   +       
Sbjct: 2326 -----TGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGS 2380

Query: 462  SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSL----GNATSTLDFHANAARLLISP 517
             P    T G     L +      DSGEY C    S      +   T++   +   L ++P
Sbjct: 2381 LPVRHQTHGS---LLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTP 2437

Query: 518  -------AAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALL---HEGPGSSLLLPAASS 567
                   +++V EGQ + L+C   ++    A+ +W+  G  L   H+  GS L L   + 
Sbjct: 2438 TVRIESSSSQVAEGQTLDLNCL--VAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTP 2495

Query: 568  TDAGSYHCRARDGHSASGPSSPAVLTVLYP------PRQPTFTTRLDLDAAGAGAGRRGL 621
             D+G Y CR      +SG    +VL  +         +   +  R++  +A    G    
Sbjct: 2496 ADSGEYVCRVV---GSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLD 2552

Query: 622  LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLL 681
            L C V S  P  +    +      SLPS            R ++  +    R+ I     
Sbjct: 2553 LNCLVASQAPHTITWYKR----GGSLPS------------RHQIVGS----RLRIPQVTP 2592

Query: 682  EEEGLYLCEASNALGNASTSATF----NGQATVLAIAP-------SHTLQEGTEANLTCN 730
             + G Y+C  SN  G+  TS       +G + V +++P       S T+ EG   +L C 
Sbjct: 2593 ADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCV 2652

Query: 731  VSREAAGSPANFSWFRNGVLWAQGPLET--------VTLLPVARTDAALYACRILTEAGA 782
            V+R+     A  +W++ G     G L +        + L  ++  D+  Y CR      A
Sbjct: 2653 VARQPQ---AIITWYKRG-----GSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDA 2704

Query: 783  QLSTPVLLSVLYPPDRPK-----LSALLDMGQGHMALFICTVDSRPLALLALFHGE-HLL 836
             L   +++SV      P      +   ++    H+A      +   L L  +  G+ H  
Sbjct: 2705 -LEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVA------EGETLDLNCVVPGQAHAQ 2757

Query: 837  AT--SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894
             T    G  +PSH + +        +L +  +   DSG Y C      G    S+   + 
Sbjct: 2758 VTWHKRGGSLPSHHQTRGS------RLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIE 2811

Query: 895  GAW--------------VQVSPSPE-LQEGQAVVLSC----QVHTGVPEGTSYRWYRDGQ 935
             +               +++ PS   + EGQ + L C    Q H  V       W++ G 
Sbjct: 2812 ASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVT------WHKRGG 2865

Query: 936  PL---QESTSATLRFAAITLTQAGAYHCQA-----------------QAPGSATT-SLAA 974
             L    +     LR   ++   +G Y CQ                   +PG      LA 
Sbjct: 2866 NLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQ 2925

Query: 975  PISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034
            PI +  S +  HVT    +D        L C V     AQ+        + +  Q     
Sbjct: 2926 PIYIEASSS--HVTEGQTLD--------LNCVVPGQAHAQVTWYKRGGSLPARHQ----T 2971

Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQA-----------SASADFD 1083
             GS  RLH+ V+P             D G Y+C A++  G             S  + + 
Sbjct: 2972 HGSQLRLHL-VSP------------ADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYR 3018

Query: 1084 AQAVNVQVWP-GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLD-AHSIPLPNVTV 1141
             ++  + + P  +TV++GQ  +  CL+     A ++  W    Q+  D  H  P  ++  
Sbjct: 3019 LRSPVISIDPPSSTVQQGQDASFKCLIHDG-AAPISLEWKTRNQELEDNVHISPNGSIIT 3077

Query: 1142 RDAT------SYRC------GVGPPGRAPRLSRPITLDVL-----YAPRNLRLTYLLESH 1184
               T      +YRC      GV        +  P T+ VL     +      +T    S 
Sbjct: 3078 IVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSA 3137

Query: 1185 GGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSAR 1244
            G   +    T  S  PA+L     G  L  S A        L++   +P D G Y C A+
Sbjct: 3138 GEPRSSARWTRISSTPAKLEQRTYG--LMDSHAV-------LQISSAKPSDAGTYVCLAQ 3188

Query: 1245 SPLGQANTSLELRLE------GVRVILAPEA--AVPEGAPITVTCADPAAHAPTLYTWYH 1296
            + LG A   +E+ ++      G   + A EA   V  G   T+ C+   + APT++ W  
Sbjct: 3189 NALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIH-WSK 3247

Query: 1297 NGR---WLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSS 1353
                  W       +L      +  +G Y C A    G  +     L V   P    +  
Sbjct: 3248 LRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAG-HAEATIILHVESPPYATTVPE 3306

Query: 1354 FRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQV 1413
                +A     +QC     PP     S  G  L   +              ARN L    
Sbjct: 3307 HASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRA-------------TARNELLHFE 3353

Query: 1414 QDVPAGDDTYVCTAQNLLGSISTIGRLQVEGA---------------RVVAEPGLDVPE- 1457
            +  P     Y C   N +GS     +L V+G                 V   P L+    
Sbjct: 3354 RAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSI 3413

Query: 1458 GAALNLSCRLLGGPGPVGNSTFAWFWNDRRL---HAEPVPTLAFTHVARAQAGMYHCLAE 1514
            GA++   C +    G    +   WF    +L   H+     L   ++ ++  G Y C A 
Sbjct: 3414 GASVEFHCAVPSDRG----TQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAH 3469

Query: 1515 LPTGAA-ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLV 1573
             P G A ASA ++++ L     P++++       +R  +   V    +    L LG    
Sbjct: 3470 GPWGKAQASAQLVIQAL-----PSVLI------NIRTSVQTVVVGHAVEFECLALGD--- 3515

Query: 1574 ASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRAL 1633
               Q   +    H+      +   V I  +  +D G+Y C+A+N  G+  +     V+AL
Sbjct: 3516 PKPQVTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQAL 3575

Query: 1634 HRLHQFQQL 1642
             ++   Q++
Sbjct: 3576 PQISMPQEV 3584



 Score =  117 bits (292), Expect = 1e-25
 Identities = 221/958 (23%), Positives = 352/958 (36%), Gaps = 170/958 (17%)

Query: 93   PEH---RVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTL-------VTVTEEPRVP 142
            P H   R   L L  + P DSG Y  R   S     + V  T+       V V      P
Sbjct: 2768 PSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAP 2827

Query: 143  TIA---SPVELLEGTEVDFNCSTPYVCLQEQVRLQWQ---GQDPARSVTFNSQKFEPTGV 196
             I    S   + EG  +D  C  P    Q   ++ W    G  PAR              
Sbjct: 2828 PIRIEPSSSRVAEGQTLDLKCVVPG---QAHAQVTWHKRGGNLPARHQVH---------- 2874

Query: 197  GHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGV--------KILLSPS 248
            G L  L+  +S  D G    CQ++ ++   ++ + + ++ +  G          I +  S
Sbjct: 2875 GPLLRLNQ-VSPADSGEY-SCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEAS 2932

Query: 249  GRNILPGELVTLTCQVNSSYPAVSSIKWLKDG----VRLQTKTGVLHLPQAAWSDAGVYT 304
              ++  G+ + L C V     A + + W K G     R QT    L L   + +D+G Y 
Sbjct: 2933 SSHVTEGQTLDLNCVVPGQ--AHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYV 2990

Query: 305  CQAENGVG-------SLVSPPISLHIFMAEVQV----SPAGPILENQTVTLVCNTPNEAP 353
            C+A +G G       ++  PP     +     V     P+  + + Q  +  C   ++  
Sbjct: 2991 CRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLI-HDGA 3049

Query: 354  SDLRYSWYKNHVLLED----AHSHTLRLHLATR-ADTGFYFCEVQNVHGSERSGPVSVVV 408
            + +   W   +  LED    + + ++   + TR ++ G Y C   N +G  +S  V++ V
Sbjct: 3050 APISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQS-VVNLSV 3108

Query: 409  NHPPLTPVLTAF-LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSG 467
            + PP   VL    +  + G    L C    EP ++   +     ++ST    +   R  G
Sbjct: 3109 HGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTR----ISSTPAKLEQ--RTYG 3162

Query: 468  TSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE---- 523
                +++ L+I   + +D+G Y C A N+LG A   ++   +   +  +P A  V+    
Sbjct: 3163 LMDSHAV-LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAM--APGAPQVQAEEA 3219

Query: 524  ------GQAVTLSCRSGLSPTPDARFSWYLNGAL--LHEGPGSSLLLPAASSTDAGSYHC 575
                  G   TL C +  SP P   +S  L   L   H   G +L++P  +  D+G Y C
Sbjct: 3220 ELTVEAGHTATLRCSATGSPAPTIHWS-KLRSPLPWQHRLEGDTLIIPRVAQQDSGQYIC 3278

Query: 576  RARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635
                  +A+ P+  A  T++     P + T +  + A   AG    L C     PP   Q
Sbjct: 3279 ------NATSPAGHAEATIILHVESPPYATTVP-EHASVQAGETVQLQCLAHGTPPLTFQ 3331

Query: 636  LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695
                   V +SLP               + T    LL  E   P  E+ G Y C  +N +
Sbjct: 3332 WSR----VGSSLPG--------------RATARNELLHFERAAP--EDSGRYRCRVTNKV 3371

Query: 696  GNA----------------STSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSP 739
            G+A                +TS       TV       T   G      C V  +     
Sbjct: 3372 GSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRG--- 3428

Query: 740  ANFSWFRNGVLWAQGPLETVTLLPVARTDAAL---YACRI-----LTEAGAQLSTPVLLS 791
                WF+ G     G      +L +   D +    Y C+        +A AQL    L S
Sbjct: 3429 TQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPS 3488

Query: 792  VLYPPDRPKLSALLDMGQGHMALFICTV--DSRPLALLALFHGEHLLATSLGPQVPSHGR 849
            VL        + ++    GH   F C    D +P    +   G       L P +   G 
Sbjct: 3489 VLINIRTSVQTVVV----GHAVEFECLALGDPKPQVTWSKVGGH------LRPGIVQSGG 3538

Query: 850  FQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQ-- 907
                       + +  + L D+G YRC ATN  G++ + +   V+ A  Q+S   E++  
Sbjct: 3539 V----------VRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQ-ALPQISMPQEVRVP 3587

Query: 908  EGQAVVLSCQVHTGVPEGTSYRWYR-DGQ--PLQESTSATLRFAAITLTQAGAYHCQA 962
             G A V  C + +G P      W + DG   P     +  L   ++    AG Y C A
Sbjct: 3588 AGSAAVFPC-IASGYPT-PDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTA 3643



 Score = 33.5 bits (75), Expect = 1.8
 Identities = 15/40 (37%), Positives = 21/40 (52%)

Query: 844 VPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLG 883
           +PSH R    +E     L +R++   D G+Y CEA N  G
Sbjct: 447 IPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486



 Score = 32.3 bits (72), Expect = 4.1
 Identities = 16/36 (44%), Positives = 21/36 (58%)

Query: 463 PRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG 498
           PR + TS      L IRD++E+D G Y C A N+ G
Sbjct: 451 PRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486


>gi|157168355 CD22 molecule [Homo sapiens]
          Length = 847

 Score =  178 bits (452), Expect = 4e-44
 Identities = 174/659 (26%), Positives = 286/659 (43%), Gaps = 73/659 (11%)

Query: 5   PKLLLLASFFPA--GQASWGVSSPQDVQGVKGSCLLIPCIF-SFPADVEVPDGITAIWYY 61
           P LLLL   + A    + W    P+ +   +G+C+ IPC + +   D+E     + I ++
Sbjct: 6   PWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLE-----SFILFH 60

Query: 62  DYSGQRQVVSHSADPKLVEARFRG-------RTEFMGNPEHRVCNLLLKDLQPEDSGSYN 114
           +    +   S     +L E+   G       R +F+G+ +++ C L +  +   DSG   
Sbjct: 61  NPEYNKNT-SKFDGTRLYESTKDGKVPSEQKRVQFLGD-KNKNCTLSIHPVHLNDSGQLG 118

Query: 115 FRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQ 174
            R E S+  +W  ++   + V+E P  P I  P E+ E  EV   C   + C    ++LQ
Sbjct: 119 LRME-SKTEKW--MERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQ 175

Query: 175 WQGQD-PARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHR--AQSEIH 231
           W  +  P R     S       V     L  +  W  HG+I+ CQL  A+ +  +   + 
Sbjct: 176 WLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQ 235

Query: 232 LQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTK-TGVL 290
           L VK+ PK ++I ++PS   +  G+ VT+TC+V+SS P  +++ WLKDG  L+ + T  L
Sbjct: 236 LNVKHTPK-LEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTL 294

Query: 291 HLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPA--------GPILENQTV 342
           +L +     +G Y CQ  N VG    P  S  +F+ +VQ +P          P +E   V
Sbjct: 295 NLREVTKDQSGKYCCQVSNDVG----PGRSEEVFL-QVQYAPEPSTVQILHSPAVEGSQV 349

Query: 343 TLVC-NTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERS 401
             +C +  N  P++  Y+WY N   ++      + +        G Y C  +N+ G+ + 
Sbjct: 350 EFLCMSLANPLPTN--YTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQR 407

Query: 402 GP-VSVVVNHPP--LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGD 458
           GP   + V +PP  +T V+   +  + G    L C+  S   +        H        
Sbjct: 408 GPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPH-------- 459

Query: 459 SDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR-----L 513
                       P+   L+I+++   D+    C+A NS  +  S +  +   A       
Sbjct: 460 -------GAWEEPSLGVLKIQNV-GWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVR 511

Query: 514 LISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSY 573
            I P +E+  G +V+L C    S   + +F W  NG LL  G  S L   + S  DAGSY
Sbjct: 512 KIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLL--GKESQLNFDSISPEDAGSY 569

Query: 574 HCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAG-AGAGRRGLLLCRVDSDPP 631
            C   +    +  S    L VLY PR+     R+ +        G+   L C  D++PP
Sbjct: 570 SCWVNNSIGQTA-SKAWTLEVLYAPRR----LRVSMSPGDQVMEGKSATLTCESDANPP 623



 Score =  102 bits (254), Expect = 3e-21
 Identities = 128/516 (24%), Positives = 204/516 (39%), Gaps = 90/516 (17%)

Query: 711  LAIAPSHTL-QEGTEANLTCNVSREAAGSP--ANFSWFRNGVLWAQGPLETVTLLPVART 767
            + + PS  + +EG    +TC VS   + +P     SW ++G    +    T+ L  V + 
Sbjct: 246  IKVTPSDAIVREGDSVTMTCEVS---SSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKD 302

Query: 768  DAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMG-QGHMALFICTVDSRPLAL 826
             +  Y C++  + G   S  V L V Y P+   +  L     +G    F+C   + PL  
Sbjct: 303  QSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPT 362

Query: 827  LALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN 886
               ++              +    Q + E    K+ + ++    +G+Y C A N+LG+  
Sbjct: 363  NYTWY-------------HNGKEMQGRTEE---KVHIPKILPWHAGTYSCVAENILGTGQ 406

Query: 887  TSLFFQVRGAWVQVSPSPE-----------LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQ 935
                    GA + V   P+           ++EG  V LSC  ++  P  T Y W   G 
Sbjct: 407  RG-----PGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHG- 460

Query: 936  PLQESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHV---TLTTL 992
              +E +   L+   +           A A  ++  S A+P++L+V YAPR V    +  L
Sbjct: 461  AWEEPSLGVLKIQNVGWDNTTI----ACAACNSWCSWASPVALNVQYAPRDVRVRKIKPL 516

Query: 993  MDTGPGRLGLLLCRVDSDPPAQLRLL--HGDRLVASTLQGVGGPEGSSPRLHVAVAPNTL 1050
             +   G    L C   S  P +++       RL+    Q                     
Sbjct: 517  SEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ--------------------- 555

Query: 1051 RLEIHGAMLEDEGVYICEASNTLGQASASA-----DFDAQAVNVQVWPGATVREGQLVNL 1105
             L       ED G Y C  +N++GQ ++ A      +  + + V + PG  V EG+   L
Sbjct: 556  -LNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATL 614

Query: 1106 TCLVWTTHPAQLTYTWYQDGQQRLDAHS--IPLPNVTVRDATSYRC----GVGPPGRAPR 1159
            TC     +P    YTW+    Q L  HS  + L  V V+ + +Y C     VG  GR+P 
Sbjct: 615  TC-ESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVG-KGRSP- 671

Query: 1160 LSRPITLDVLYAPRNL--RLTYLLESHGGQLALVLC 1193
            LS   TL V Y+P  +  R+   L S    L L +C
Sbjct: 672  LS---TLTVYYSPETIGRRVAVGLGSCLAILILAIC 704



 Score = 95.9 bits (237), Expect = 3e-19
 Identities = 123/480 (25%), Positives = 198/480 (41%), Gaps = 71/480 (14%)

Query: 1087 VNVQVWPG-ATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQ--QRLDAHSIPLPNVTVRD 1143
            + ++V P  A VREG  V +TC V +++P   T +W +DG   ++ +  ++ L  VT   
Sbjct: 244  LEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQ 303

Query: 1144 ATSYRCGVG---PPGRAPRLSRPITLDVLYAPR--NLRLTYLLESHGGQLALVLCTVDSR 1198
            +  Y C V     PGR    S  + L V YAP    +++ +     G Q+  +  ++ + 
Sbjct: 304  SGKYCCQVSNDVGPGR----SEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANP 359

Query: 1199 PPAQLALSHAGRLLASSTAASV--PNTLRLELRGPQPRDEGFYSCSARSPL--GQANTSL 1254
             P      H G+ +   T   V  P  L        P   G YSC A + L  GQ     
Sbjct: 360  LPTNYTWYHNGKEMQGRTEEKVHIPKIL--------PWHAGTYSCVAENILGTGQRGPGA 411

Query: 1255 ELRLE----GVRVILAPEAAVPEGAPITVTCADPAAH-APTLYTWYHNGRWLQEGPAASL 1309
            EL ++     V  ++     + EG  +T++C   +++ + T Y W  +G W  E P+  +
Sbjct: 412  ELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAW--EEPSLGV 469

Query: 1310 SFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR---DSRARSMAVIQ 1366
              +          +C A ++  + +S P AL V YAP+D  +   +   +  + +   +Q
Sbjct: 470  LKIQNVGWDNTTIACAACNSWCSWAS-PVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQ 528

Query: 1367 CTVDSEPPAELAL--SHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV-PAGDDTY 1423
            C   S  P E+      +G++L   S                   +L    + P    +Y
Sbjct: 529  CDFSSSHPKEVQFFWEKNGRLLGKES-------------------QLNFDSISPEDAGSY 569

Query: 1424 VCTAQNLLG-SISTIGRLQVEGA----RVVAEPGLDVPEGAALNLSCRLLGGPGPVGNST 1478
             C   N +G + S    L+V  A    RV   PG  V EG +  L+C     P PV  S 
Sbjct: 570  SCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANP-PV--SH 626

Query: 1479 FAWF-WNDRRL--HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKT 1535
            + WF WN++ L  H++    L    V    +G Y C      G   S    L V Y P+T
Sbjct: 627  YTWFDWNNQSLPYHSQ---KLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPET 683



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 114/420 (27%), Positives = 180/420 (42%), Gaps = 53/420 (12%)

Query: 201 TLHMAMSWQDHGRILRCQLS--VANHRAQSEIHLQVKYAPKG--VKILLSPSGRNILPGE 256
           TL++    +D      CQ+S  V   R++ E+ LQV+YAP+   V+IL SP+    + G 
Sbjct: 293 TLNLREVTKDQSGKYCCQVSNDVGPGRSE-EVFLQVQYAPEPSTVQILHSPA----VEGS 347

Query: 257 LVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV-LHLPQAAWSDAGVYTCQAENGVGS-L 314
            V   C ++ + P  ++  W  +G  +Q +T   +H+P+     AG Y+C AEN +G+  
Sbjct: 348 QVEFLC-MSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQ 406

Query: 315 VSPPISLHIFMAEVQVSPA----GPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDA 370
             P   L +     +V+       PI E  TVTL CN  +  PS  RY W K H   E+ 
Sbjct: 407 RGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEW-KPHGAWEEP 465

Query: 371 HSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL---TPVLTAFLETQAGL 427
               L++      +T    C   N   S  S PV++ V + P       +    E  +G 
Sbjct: 466 SLGVLKIQNVGWDNTTIA-CAACNSWCSWAS-PVALNVQYAPRDVRVRKIKPLSEIHSGN 523

Query: 428 VGILHCSVVSEPLATLVL--SHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETD 485
              L C   S     +       G +L   S                  +L    +   D
Sbjct: 524 SVSLQCDFSSSHPKEVQFFWEKNGRLLGKES------------------QLNFDSISPED 565

Query: 486 SGEYKCSATNSLGNATS---TLD--FHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPD 540
           +G Y C   NS+G   S   TL+  +     R+ +SP  +V+EG++ TL+C S  +P P 
Sbjct: 566 AGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANP-PV 624

Query: 541 ARFSWY--LNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
           + ++W+   N +L +      L L       +G+Y C+  +     G S  + LTV Y P
Sbjct: 625 SHYTWFDWNNQSLPYH--SQKLRLEPVKVQHSGAYWCQGTNS-VGKGRSPLSTLTVYYSP 681



 Score = 84.3 bits (207), Expect = 9e-16
 Identities = 136/593 (22%), Positives = 234/593 (39%), Gaps = 88/593 (14%)

Query: 830  FHGEHLLATSLGPQVPSHG-RFQAKAEAN-SLKLEVRELGLGDSGSY--RCEATNVLGSS 885
            F G  L  ++   +VPS   R Q   + N +  L +  + L DSG    R E+       
Sbjct: 71   FDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWME 130

Query: 886  NTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVH---TGVPEGTSYRWYRDGQPLQE--- 939
               L    R     +   PE+QE Q V L+C ++    G P     +W  +G P+++   
Sbjct: 131  RIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYP--IQLQWLLEGVPMRQAAV 188

Query: 940  -STSATLRF----AAITLTQAGAYH-----CQAQ-APGSATTSLAAPISLHVSYAPRHVT 988
             STS T++     + +  +   ++H     CQ Q A G   ++    + L+V + P+   
Sbjct: 189  TSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSN--DTVQLNVKHTPKLEI 246

Query: 989  LTTLMD--TGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVA 1046
              T  D     G    + C V S  P        +    S L+     +G+S +      
Sbjct: 247  KVTPSDAIVREGDSVTMTCEVSSSNP--------EYTTVSWLK-----DGTSLK-----K 288

Query: 1047 PNTLRLEIHGAMLEDEGVYICEASNTLG-----QASASADFDAQAVNVQVWPGATVREGQ 1101
             NT  L +     +  G Y C+ SN +G     +      +  +   VQ+     V EG 
Sbjct: 289  QNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAV-EGS 347

Query: 1102 LVNLTCLVWTTHPAQLTYTWYQDGQ--QRLDAHSIPLPNVTVRDATSYRC------GVGP 1153
             V   C+    +P    YTWY +G+  Q      + +P +    A +Y C      G G 
Sbjct: 348  QVEFLCMS-LANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQ 406

Query: 1154 PGRAPRLSRPITLDVLYAPRNLRLTYLLES----HGGQLALVLCTVDSRPPAQLALSHAG 1209
             G          LDV Y P+  ++T ++++      G    + C  +S  P+        
Sbjct: 407  RGPGAE------LDVQYPPK--KVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKP 458

Query: 1210 RLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE----GVRV-I 1264
                   +  V   L+++  G    D    +C+A +      + + L ++     VRV  
Sbjct: 459  HGAWEEPSLGV---LKIQNVG---WDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRK 512

Query: 1265 LAPEAAVPEGAPITVTCADPAAHAPTL-YTWYHNGRWLQEGPAASLSFLVATRAHAGAYS 1323
            + P + +  G  +++ C   ++H   + + W  NGR L  G  + L+F   +   AG+YS
Sbjct: 513  IKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLL--GKESQLNFDSISPEDAGSYS 570

Query: 1324 CQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPP 1374
            C   ++ G  +S+   L+VLYAP+   +S     +      A + C  D+ PP
Sbjct: 571  CWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPP 623



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 57/191 (29%), Positives = 87/191 (45%), Gaps = 6/191 (3%)

Query: 228 SEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKT 287
           S + L V+YAP+ V++        I  G  V+L C  +SS+P      W K+G RL  K 
Sbjct: 495 SPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNG-RLLGKE 553

Query: 288 GVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA----EVQVSPAGPILENQTVT 343
             L+    +  DAG Y+C   N +G   S   +L +  A     V +SP   ++E ++ T
Sbjct: 554 SQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSAT 613

Query: 344 LVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGP 403
           L C +    P    Y+W+  +      HS  LRL       +G Y+C+  N  G  RS  
Sbjct: 614 LTCESDANPPVS-HYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPL 672

Query: 404 VSVVVNHPPLT 414
            ++ V + P T
Sbjct: 673 STLTVYYSPET 683



 Score = 68.6 bits (166), Expect = 5e-11
 Identities = 115/526 (21%), Positives = 192/526 (36%), Gaps = 85/526 (16%)

Query: 520  EVVEGQAVTLSCRSGLSPTP-DARFSWYLNGALLHEGPGSSLLLPAASS--------TDA 570
            E+ E Q VTL+C    S      +  W L G  + +   +S  L   S         +  
Sbjct: 150  EIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQ 209

Query: 571  GSYH-----CRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCR 625
             S+H     C+ +D       +    L V + P+     T  D   A    G    + C 
Sbjct: 210  WSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSD---AIVREGDSVTMTCE 266

Query: 626  VDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685
            V S  P        +    + L  G                K  N   + +     ++ G
Sbjct: 267  VSSSNP--------EYTTVSWLKDGTSL-------------KKQNTFTLNLREVTKDQSG 305

Query: 686  LYLCEASNALGNASTSATF-----NGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740
             Y C+ SN +G   +   F       + + + I  S  + EG++    C     A   P 
Sbjct: 306  KYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAV-EGSQVEFLC--MSLANPLPT 362

Query: 741  NFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAG-AQLSTPVLLSVLYPPDRP 799
            N++W+ NG        E V +  +    A  Y+C      G  Q      L V YPP + 
Sbjct: 363  NYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKK- 421

Query: 800  KLSALLDMGQGHMALFICTVDSRPLALLALFHGEHL-LATSLGPQVPSHGRFQAK----- 853
                            + TV   P+ +     G+ + L+ +     PS  R++ K     
Sbjct: 422  ----------------VTTVIQNPMPIR---EGDTVTLSCNYNSSNPSVTRYEWKPHGAW 462

Query: 854  AEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGA-----WVQVSPSPELQE 908
             E +   L+++ +G  D+ +  C A N   S  + +   V+ A       ++ P  E+  
Sbjct: 463  EEPSLGVLKIQNVG-WDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHS 521

Query: 909  GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSA 968
            G +V L C   +  P+   + W ++G+ L + +   L F +I+   AG+Y C        
Sbjct: 522  GNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ--LNFDSISPEDAGSYSCWVNNSIGQ 579

Query: 969  TTSLAAPISLHVSYAPR--HVTLTTLMDTGPGRLGLLLCRVDSDPP 1012
            T S A   +L V YAPR   V+++       G+   L C  D++PP
Sbjct: 580  TASKA--WTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPP 623



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 82/383 (21%), Positives = 144/383 (37%), Gaps = 72/383 (18%)

Query: 1268 EAAVPEGAPITVTCADPAAHAP-TLYTWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQA 1326
            +A V EG  +T+TC   +++   T  +W  +G  L++    +L+    T+  +G Y CQ 
Sbjct: 252  DAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQV 311

Query: 1327 QDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR-SMAVIQCTVDSEP-PAELALSHDGK 1384
             +  G   S    LQV YAP+ + +          S     C   + P P      H+GK
Sbjct: 312  SNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGK 371

Query: 1385 VL--ATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV 1442
             +   T   VH                    + +P    TY C A+N+LG+       ++
Sbjct: 372  EMQGRTEEKVHI------------------PKILPWHAGTYSCVAENILGTGQRGPGAEL 413

Query: 1443 E------GARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAW----FWNDRRLHAEP 1492
            +          V +  + + EG  + LSC        V  + + W     W +  L    
Sbjct: 414  DVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSV--TRYEWKPHGAWEEPSLGVLK 471

Query: 1493 VPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGIL 1552
            +  + + +   A        A   +  + ++PV L V Y P+                  
Sbjct: 472  IQNVGWDNTTIA-------CAACNSWCSWASPVALNVQYAPR------------------ 506

Query: 1553 DCRVDS-EPLASLTLHLGSRL-----VASSQPQGAPA--EPHIHVLASPNALRVDIEALR 1604
            D RV   +PL+   +H G+ +      +SS P+      E +  +L   + L  D  ++ 
Sbjct: 507  DVRVRKIKPLSE--IHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFD--SIS 562

Query: 1605 PSDQGEYICSASNVLGSASTSTY 1627
            P D G Y C  +N +G  ++  +
Sbjct: 563  PEDAGSYSCWVNNSIGQTASKAW 585


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  170 bits (431), Expect = 1e-41
 Identities = 378/1698 (22%), Positives = 598/1698 (35%), Gaps = 312/1698 (18%)

Query: 84   RGRTEFMGNPEHRVCN----LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEP 139
            +G +  + + EH V N    L +    P D+G Y     ++     +D     + V E P
Sbjct: 1206 KGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTC---VATNIAGTDETEITLHVQEPP 1262

Query: 140  RVPTIASPV-----ELLEGTEVDFNC---STPYVCLQEQVRLQWQGQDPARSVTFNSQKF 191
             V  +  P      E +    ++F C    TP      +  ++W      R +T      
Sbjct: 1263 TVEDLEPPYNTTFQERVANQRIEFPCPAKGTP------KPTIKWLHN--GRELTGREPGI 1314

Query: 192  EPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRN 251
                 G L  +     + D+G  +   ++ A    + + +L+V + P  +K     +  +
Sbjct: 1315 SILEDGTLLVIASVTPY-DNGEYICVAVNEAG-TTERKYNLKV-HVPPVIKDKEQVTNVS 1371

Query: 252  ILPGELVTLTCQVNSSYPAVSSIKWLKDGVR------LQTKTG--VLHLPQAAWSDAGVY 303
            +L  +L  L C+V  +   +  I W KD V+      +QT     +L L +A   DAG Y
Sbjct: 1372 VLLNQLTNLFCEVEGTPSPI--IMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRY 1429

Query: 304  TCQAENGVGS---------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPS 354
            +C+A N  G+         LV P I    F  EV V      + N+ V L C        
Sbjct: 1430 SCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSV------VLNRDVALECQVKGTPFP 1483

Query: 355  DLRYSWYKNH--VLLEDAHSHTLR----LHL--ATRADTGFYFCEVQNVHGSERSGPVSV 406
            D+   W+K+   + L D +   L     LHL  A R D G Y C V N  G +    + +
Sbjct: 1484 DIH--WFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKD-IKL 1540

Query: 407  VVNHPPLTPV--LTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTS-------G 457
             +  PP      +T  +      +  L C     P+  +     G  + S+S       G
Sbjct: 1541 TIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKG 1600

Query: 458  DSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANA------- 510
               H PR                 + +DS  Y C   N  G A  +  FH +        
Sbjct: 1601 QYLHIPR----------------AQVSDSATYTCHVANVAGTAEKS--FHVDVYVPPMIE 1642

Query: 511  ARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH-------EGPGSSLLLP 563
              L      +VV   ++TL C++  +P+P    +W  +G  +        E  G  L + 
Sbjct: 1643 GNLATPLNKQVVIAHSLTLECKAAGNPSPI--LTWLKDGVPVKANDNIRIEAGGKKLEIM 1700

Query: 564  AASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQP----------TFTTRLDLDAAG 613
            +A   D G Y C A     A        + VL PP                  L+LD   
Sbjct: 1701 SAQEIDRGQYICVATS--VAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELD--- 1755

Query: 614  AGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLR 673
                      C V   PP  +  L   +++                  R       N  +
Sbjct: 1756 ----------CHVTGSPPPTIMWLKDGQLI----------------DERDGFKILLNGRK 1789

Query: 674  VEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSR 733
            + I    +   GLY C A+N  G+         +  V    P      G    +      
Sbjct: 1790 LVIAQAQVSNTGLYRCMAANTAGDHKK------EFEVTVHVPPTIKSSGLSERVVVKYKP 1843

Query: 734  EAAGSPAN------FSWFRNG--VLWAQGPLETVT---LLPVART---DAALYACRILTE 779
             A    AN       +W ++   V  AQG L+  +   +L +A+T   DA  Y C + T 
Sbjct: 1844 VALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTC-VATN 1902

Query: 780  AGAQLSTPVLLSVLYPPDRPKLSALLD--MGQGHMALFICTVDSRPLALLALFHGEHLLA 837
            A  +    + L V  PP       +L+  +   +     C     P+ ++  +    LL+
Sbjct: 1903 AAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLS 1962

Query: 838  TSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAW 897
             S      + G+           +++    + D+G Y+C A N  G+  T LF+ ++   
Sbjct: 1963 GSTSMTFLNRGQI----------IDIESAQISDAGIYKCVAINSAGA--TELFYSLQ--- 2007

Query: 898  VQVSPSPELQEGQAVV-------LSCQVHTGVPEGTSYRWYRDGQPLQE--------STS 942
            V V+PS         V       L C+   G+P   S  W +DG P+          S  
Sbjct: 2008 VHVAPSISGSNNMVAVVVNNPVRLECEAR-GIP-APSLTWLKDGSPVSSFSNGLQVLSGG 2065

Query: 943  ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL 1002
              L   +  ++  G Y C A    +A       I L V   P  +     +     +   
Sbjct: 2066 RILALTSAQISDTGRYTCVAV---NAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVE 2122

Query: 1003 LLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDE 1062
            LLC+ D+ PP  L  L             G P    P L  +++ N   L+I  A ++D 
Sbjct: 2123 LLCQSDAIPPPTLTWLKD-----------GHPLLKKPGL--SISENRSVLKIEDAQVQDT 2169

Query: 1063 GVYICEASNTLGQASASADFDAQAVNVQVWPGA---------TVREGQLVNLTCLVWTTH 1113
            G Y CEA+N  G+   + +     VN+ V P           TV EG L++L C      
Sbjct: 2170 GRYTCEATNVAGKTEKNYN-----VNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIP 2224

Query: 1114 PAQLTYTWYQDGQQRLD-----------AHSIPLPNVTVRDATSYRCGVGPPGRAPRLSR 1162
            P  L   W + G   L               + +      DA  Y C       A    +
Sbjct: 2225 PPNLI--WKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVAS--NVAGTAKK 2280

Query: 1163 PITLDVLYAPR----NLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAA 1218
               L V   P         T ++ + G  ++L  C V   PP  +     G  L  +   
Sbjct: 2281 EYNLQVYIRPTITNSGSHPTEIIVTRGKSISLE-CEVQGIPPPTVTWMKDGHPLIKAKGV 2339

Query: 1219 SVPNTLR-LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL----APE-AAVP 1272
             + +    L+L+     D G Y C A +  G  +   +L +     I+    +PE  +V 
Sbjct: 2340 EILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVV 2399

Query: 1273 EGAPITVTCADPAAHAPTLYTWYHNG---------RWLQEGPAASLSFLVATRAHAGAYS 1323
            E   +++TC       P++ TW+ +G         R L  G    L  +  T   AG Y+
Sbjct: 2400 EKNSVSLTCEASGIPLPSI-TWFKDGWPVSLSNSVRILSGG--RMLRLMQTTMEDAGQYT 2456

Query: 1324 CQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSM--AVIQCTVDSEPPAELALSH 1381
            C  ++A G    +   L VL  P     ++  D + +      + C V   P  E+    
Sbjct: 2457 CVVRNAAG-EERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHK 2515

Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQ 1441
            DG+ L      H + SG   +Q+        VQ    G   Y C A +  G  S    L 
Sbjct: 2516 DGQPLQEDEA-HHIISGGRFLQITN------VQVPHTG--RYTCLASSPAGHKSRSFSLN 2566

Query: 1442 VEGARVVAEPGLDV-PEGAA--LNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP----VP 1494
            V  +  +A  G D  PE     LN    L+        +T  WF +   L +      +P
Sbjct: 2567 VFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILP 2626

Query: 1495 ---TLAFTHVARAQAGMYHCLAELPTGAAAS--------APVMLRV-LYPPKTPTMMVFV 1542
               TL   +     AG Y C+A    G             P++ +  L+ P      V +
Sbjct: 2627 GGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKI 2686

Query: 1543 EPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEA 1602
            +    L   L+C   + P ASL+ +            G P +   HV  + N   + I+ 
Sbjct: 2687 KVNNTLT--LECEAYAIPSASLSWY----------KDGQPLKSDDHVNIAANGHTLQIKE 2734

Query: 1603 LRPSDQGEYICSASNVLG 1620
             + SD G Y C ASN+ G
Sbjct: 2735 AQISDTGRYTCVASNIAG 2752



 Score =  170 bits (431), Expect = 1e-41
 Identities = 355/1578 (22%), Positives = 568/1578 (35%), Gaps = 297/1578 (18%)

Query: 214  ILRCQLS--VANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAV 271
            + RC  +    +H+ + E+ + V    K   +    S R ++  + V L C  N      
Sbjct: 1802 LYRCMAANTAGDHKKEFEVTVHVPPTIKSSGL----SERVVVKYKPVALQCIANGI--PN 1855

Query: 272  SSIKWLKD---------GVRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLH 322
             SI WLKD          +++Q+   VL + +    DAG YTC A N  G      I LH
Sbjct: 1856 PSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGE-TQQHIQLH 1914

Query: 323  IFMAEVQVSPAGPILENQTVTLVCN--------TPNEAPSDLRYSWYKNHVLLEDAHSHT 374
            +      +  AG +L N+TV LV N          N  P     +WYK++ LL  + S T
Sbjct: 1915 VH-EPPSLEDAGKML-NETV-LVSNPVQLECKAAGNPVPV---ITWYKDNRLLSGSTSMT 1968

Query: 375  -------LRLHLATRADTGFYFCEVQNVHG----------------SERSGPVSVVVNHP 411
                   + +  A  +D G Y C   N  G                S  +  V+VVVN+P
Sbjct: 1969 FLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNP 2028

Query: 412  PLTPVLTAFLETQA------GLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRF 465
                     LE +A       L  +   S VS     L +  GG ILA TS         
Sbjct: 2029 -------VRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSA-------- 2073

Query: 466  SGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA--AEVVE 523
                            + +D+G Y C A N+ G     +D        ++       V+ 
Sbjct: 2074 ----------------QISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLI 2117

Query: 524  GQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPG-------SSLLLPAASSTDAGSYHCR 576
             QAV L C+S   P P    +W  +G  L + PG       S L +  A   D G Y C 
Sbjct: 2118 SQAVELLCQSDAIPPP--TLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCE 2175

Query: 577  ARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQL 636
            A    + +G +       ++ P  P      +L       G    LLC     PP  L  
Sbjct: 2176 AT---NVAGKTEKNYNVNIWVP--PNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIW 2230

Query: 637  LHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG 696
              K   V T                R+++      L++ I      +  LY C ASN  G
Sbjct: 2231 KKKGSPVLTD------------SMGRVRILSGGRQLQISIAEK--SDAALYSCVASNVAG 2276

Query: 697  NASTSATFNGQATV---LAIAPSHTLQ----EGTEANLTCNVSREAAGSPANFSWFRNG- 748
             A     +N Q  +   +  + SH  +     G   +L C V       P   +W ++G 
Sbjct: 2277 TAKKE--YNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQ---GIPPPTVTWMKDGH 2331

Query: 749  -VLWAQG-----PLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPD---RP 799
             ++ A+G         + L  +  +D   Y C  +  AG        LSV  PP      
Sbjct: 2332 PLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAG-MTDKKYDLSVHAPPSIIGNH 2390

Query: 800  KLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSL 859
            +    + + + +     C     PL  +  F     ++ S   ++ S GR          
Sbjct: 2391 RSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRM--------- 2441

Query: 860  KLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSP---------SPELQEGQ 910
             L + +  + D+G Y C   N  G        ++ G  V V P           +++E Q
Sbjct: 2442 -LRLMQTTMEDAGQYTCVVRNAAGEER-----KIFGLSVLVPPHIVGENTLEDVKVKEKQ 2495

Query: 911  AVVLSCQVHTG--VPEGTSYRWYRDGQPLQESTSATL----RFAAITLTQ---AGAYHCQ 961
            +V L+C+V TG  VPE T   W++DGQPLQE  +  +    RF  IT  Q    G Y C 
Sbjct: 2496 SVTLTCEV-TGNPVPEIT---WHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCL 2551

Query: 962  AQAP-GSATTSLAAPISLHVSYA-------PRHVTLTTLMDTGPGRLGLLLCRVDSDPPA 1013
            A +P G  + S +  + +  + A       P  VT+     T       L+C   S PPA
Sbjct: 2552 ASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTS------LVCEAYSYPPA 2605

Query: 1014 QLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTL 1073
             +           T    G P  S+   ++ + P    L+I  A  ++ G Y C A+N  
Sbjct: 2606 TI-----------TWFKDGTPLESN--RNIRILPGGRTLQILNAQEDNAGRYSCVATNEA 2652

Query: 1074 GQASASADFDAQAVNV----QVW-PGATVREGQL-----VNLTCLVWTTHPAQLTYTWYQ 1123
            G+     +       +     +W PG + +E ++     + L C  +    A L  +WY+
Sbjct: 2653 GEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASL--SWYK 2710

Query: 1124 DGQQ---------RLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRN 1174
            DGQ            + H++ +    + D   Y C          L   + + V  + + 
Sbjct: 2711 DGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQK 2770

Query: 1175 L-RLTYLLES-HGGQLALVL--------CTVDSRPPAQLALSHAGRLLASSTAASV-PNT 1223
            L  +  +L++   G+   V+        C  ++ PP  L     G  L SS    + P  
Sbjct: 2771 LWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGG 2830

Query: 1224 LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVT--- 1280
              L++   +  D G Y+C A +  G+ +   ++R+    +I    + +PE   + V    
Sbjct: 2831 RVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSA 2890

Query: 1281 ---CADPAAHAPTLYTWYHNGRWLQE-------GPAASLSFLVATRAHAGAYSCQAQDAQ 1330
               C    + AP   +W  +G+ L E            L  L       G Y C A++  
Sbjct: 2891 LIECLSSGSPAPR-NSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTA 2949

Query: 1331 GTRSSRPAALQVLYAPQDAV--LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLAT 1388
            G  S++      ++ P   +   S        +   + C V   PP +L+   + + +  
Sbjct: 2950 G--SAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKL 3007

Query: 1389 SSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV 1448
            ++    +  G          +R +V D       Y C A N  G       L V     +
Sbjct: 3008 NTNTLIVPGGR-----TLQIIRAKVSD----GGEYTCIAINQAGESKKKFSLTVYVPPSI 3058

Query: 1449 AEPG------LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRL----HAEPVPTLAF 1498
             +        ++V EG +++L C     P PV      W+ N R +    H E +     
Sbjct: 3059 KDHDSESLSVVNVREGTSVSLECESNAVPPPV----ITWYKNGRMITESTHVEILADGQM 3114

Query: 1499 THVARAQ---AGMYHCLAELPTGAAASAPVMLRVLYPP--KTPTMMVFVEPEGGLRGILD 1553
             H+ +A+    G Y C A +           L V  PP  + P   V VE        L 
Sbjct: 3115 LHIKKAEVSDTGQYVCRA-INVAGRDDKNFHLNVYVPPSIEGPEREVIVETISN-PVTLT 3172

Query: 1554 CRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYIC 1613
            C     P  ++      + + +S          + V       ++ I   + SD G Y C
Sbjct: 3173 CDATGIPPPTIAWLKNHKRIENSD--------SLEVRILSGGSKLQIARSQHSDSGNYTC 3224

Query: 1614 SASNVLGSASTSTYFGVR 1631
             ASN+ G A    +  ++
Sbjct: 3225 IASNMEGKAQKYYFLSIQ 3242



 Score =  168 bits (425), Expect = 5e-41
 Identities = 361/1530 (23%), Positives = 537/1530 (35%), Gaps = 288/1530 (18%)

Query: 250  RNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVL--------HLPQAAWSDAG 301
            ++++    ++L C+ N++ P   ++ W KDG  L +   VL         +P+A   DAG
Sbjct: 2787 KDVIINNPISLYCETNAAPPP--TLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAG 2844

Query: 302  VYTCQAENGVGS--------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVC-NTPNEA 352
             YTC A N  G         ++ PPI   I  A   +     +L N++  + C ++ + A
Sbjct: 2845 RYTCVAVNEAGEDSLQYDVRVLVPPI---IKGANSDLPEEVTVLVNKSALIECLSSGSPA 2901

Query: 353  PSDLRYSWYKN-HVLLEDAH------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVS 405
            P   R SW K+   LLED H         L++      D G Y C  +N  GS +    +
Sbjct: 2902 P---RNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKY-FN 2957

Query: 406  VVVNHPP---------LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTS 456
            + V+ PP         LT V+  F+         L C V   P   L            S
Sbjct: 2958 LNVHVPPSVIGPKSENLTVVVNNFIS--------LTCEVSGFPPPDL------------S 2997

Query: 457  GDSDHSPRFSGTSG---PNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARL 513
               +  P    T+    P    L+I   + +D GEY C A N  G +             
Sbjct: 2998 WLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS 3057

Query: 514  LISPAAE------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP-------GSSL 560
            +    +E      V EG +V+L C S   P P    +WY NG ++ E         G  L
Sbjct: 3058 IKDHDSESLSVVNVREGTSVSLECESNAVPPPV--ITWYKNGRMITESTHVEILADGQML 3115

Query: 561  LLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRG 620
             +  A  +D G Y CRA +   A        L V  PP        + ++          
Sbjct: 3116 HIKKAEVSDTGQYVCRAIN--VAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPV---- 3169

Query: 621  LLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPL 680
             L C     PP  +  L   + +  S                ++V       +++I    
Sbjct: 3170 TLTCDATGIPPPTIAWLKNHKRIENS--------------DSLEVRILSGGSKLQIARSQ 3215

Query: 681  LEEEGLYLCEASNALGNASTSATFNGQ---ATVLAIAPSH-TLQEGTEANLTCNVSREAA 736
              + G Y C ASN  G A      + Q   +   A  PS  ++  G    L CN    A 
Sbjct: 3216 HSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCN----AN 3271

Query: 737  GSPANF-SWFRNGVLWAQGPLE---------TVTLLPVARTDAALYACRILTEAGAQLST 786
            G P     W ++G   A G  E         T+ +     +D   Y C     AG +   
Sbjct: 3272 GIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEE-DR 3330

Query: 787  PVLLSVLYPP-------DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATS 839
               L+V   P       +  KL  L+D          C     P   +      + L   
Sbjct: 3331 IFNLNVYVTPTIRGNKDEAEKLMTLVDTSIN----IECRATGTPPPQI------NWLKNG 3380

Query: 840  LGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQ 899
            L   + SH R  A  +     + +    + D   Y C A+N  G  N     QV  A   
Sbjct: 3381 LPLPLSSHIRLLAAGQV----IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVF-APPN 3435

Query: 900  VSPSPELQE-----GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLT- 953
            +  S   +E     G +  ++C +  G P   S  W RDGQPL      T+    + L  
Sbjct: 3436 MDNSMGTEEITVLKGSSTSMAC-ITDGTP-APSMAWLRDGQPLGLDAHLTVSTHGMVLQL 3493

Query: 954  ------QAGAYHCQAQAPGSATTS---LAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLL 1004
                   +G Y C A       +    L      H++ +  H  ++ +++        L 
Sbjct: 3494 LKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLE----LT 3549

Query: 1005 CRVDSDPPAQLRLLHGDRLVAST--LQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDE 1062
            C     P  ++  +   R +  T  +Q +GG E                L I  A +ED 
Sbjct: 3550 CIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEV---------------LRISTAQVEDT 3594

Query: 1063 GVYICEASNTLGQASASADFDAQAVNVQVWPGA---------TVREGQLVNLTCLVWTTH 1113
            G Y C AS+  G      D     V V V P           TV   + V L C      
Sbjct: 3595 GRYTCLASSPAGD-----DDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVP 3649

Query: 1114 PAQLTYTWYQDGQQRLDA----------HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRP 1163
            P  +T  W ++G+ RL A            + + N  + D  +Y C       A + +R 
Sbjct: 3650 PPVIT--WLRNGE-RLQATPRVRILSGGRYLQINNADLGDTANYTCVAS--NIAGKTTRE 3704

Query: 1164 ITLDVLYAPRNLRLTYLLESHGGQLALVL---------CTVDSRPPAQLALSHAGRLLAS 1214
              L V   P N++        GG  +LV+         C  +  P  ++     G +LA 
Sbjct: 3705 FILTV-NVPPNIK--------GGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAG 3755

Query: 1215 STAA-SVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP---EAA 1270
            + A  S+     L ++     D G Y C A +  G     ++L++  V   +AP      
Sbjct: 3756 NHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVH-VPPSIAPGPTNMT 3814

Query: 1271 VPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGP---------AASLSFLVATRAHAGA 1321
            V      T+ C       P++  W  NG  L             + SL  +  +      
Sbjct: 3815 VIVNVQTTLACEATGIPKPSI-NWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTAT 3873

Query: 1322 YSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSH 1381
            Y C   +  G    R   L V   P  A   +       + AVI CT    P   +  + 
Sbjct: 3874 YECTVTNGAGD-DKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTK 3932

Query: 1382 DG-KVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRL 1440
            +G ++L    G   L+SG   +        L  Q   AG   Y C A+N  GS      L
Sbjct: 3933 NGIRLLPRGDGYRILSSGAIEI--------LATQLNHAG--RYTCVARNAAGSAHRHVTL 3982

Query: 1441 QVEGARVVA-EPG-LDVPEGAALNLSCRLLGGPGPVGNSTFAW------FWNDRRLHAE- 1491
             V    V+  +P  L V     + L C   G P P       W           R HA  
Sbjct: 3983 HVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPF----ITWQKEGINVNTSGRNHAVL 4038

Query: 1492 PVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPK-TPTMMVFV----EPEG 1546
            P   L  +   R  AG Y C+A+ P G A    + L V  PP  +P +  +V    +P  
Sbjct: 4039 PSGGLQISRAVREDAGTYMCVAQNPAGTALGK-IKLNVQVPPVISPHLKEYVIAVDKPI- 4096

Query: 1547 GLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPS 1606
                 L C  D  P   +T H   R +  S  Q         VL+S +   + I  ++P 
Sbjct: 4097 ----TLSCEADGLPPPDITWHKDGRAIVESIRQ--------RVLSSGS---LQIAFVQPG 4141

Query: 1607 DQGEYICSASNVLGSASTSTYFGVRALHRL 1636
            D G Y C A+NV GS+STST   V    R+
Sbjct: 4142 DAGHYTCMAANVAGSSSTSTKLTVHVPPRI 4171



 Score =  164 bits (416), Expect = 5e-40
 Identities = 330/1485 (22%), Positives = 537/1485 (36%), Gaps = 233/1485 (15%)

Query: 251  NILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV--------LHLPQAAWSDAGV 302
            N+  G  V+L C+ N+  P V  I W K+G  +   T V        LH+ +A  SD G 
Sbjct: 3070 NVREGTSVSLECESNAVPPPV--ITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQ 3127

Query: 303  YTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILE---NQTVTLVCNTPNEAPSDLRYS 359
            Y C+A N  G        L++++      P   ++    +  VTL C+     P  +  +
Sbjct: 3128 YVCRAINVAGR-DDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTI--A 3184

Query: 360  WYKNHVLLEDAHS---------HTLRLHLATRADTGFYFCEVQNVHG-SERSGPVSVVVN 409
            W KNH  +E++ S           L++  +  +D+G Y C   N+ G +++   +S+ V 
Sbjct: 3185 WLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVP 3244

Query: 410  HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTS 469
                   + + +    G    L C+    P   +     G  +AS  G+++   R S   
Sbjct: 3245 PSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIAS--GETERI-RVSA-- 3299

Query: 470  GPNSLRLEIRDLEETDSGEYKCSATNSLGN----------ATSTLDFHANAARLLISPAA 519
              N   L I     +D+G+Y C ATN  G            T T+  + + A  L++   
Sbjct: 3300 --NGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMT--- 3354

Query: 520  EVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP-------GSSLLLPAASSTDAGS 572
              +   ++ + CR+  + TP  + +W  NG  L           G  + +  A  +D   
Sbjct: 3355 --LVDTSINIECRA--TGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAV 3410

Query: 573  YHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPA 632
            Y C A   + A   +    L V  PP         ++       G    + C  D  P  
Sbjct: 3411 YTCVA--SNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVL---KGSSTSMACITDGTPAP 3465

Query: 633  RLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEAS 692
             +  L   + +   L +    ST G             LL+ E      E+ G Y C AS
Sbjct: 3466 SMAWLRDGQPLG--LDAHLTVSTHG---------MVLQLLKAET-----EDSGKYTCIAS 3509

Query: 693  NALGNASTSATFNGQATVLAIAPSHT--LQEGTEANLTCNVSRE----AAGSPA-NFSWF 745
            N  G  S             + P H    +E  E ++  N   E    A+G PA   +W 
Sbjct: 3510 NEAGEVSKHFILK------VLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWM 3563

Query: 746  RNGVLWAQ-------GPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPP-- 796
            ++G    Q       G  E + +      D   Y C   + AG       L+ V  PP  
Sbjct: 3564 KDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDD-DKEYLVRVHVPPNI 3622

Query: 797  ---DRPKLSALLDMGQGHMALFICTVDSRPLALLA-LFHGEHLLATSLGPQVPSHGRFQA 852
               D P+   +L   +       C  D+ P  ++  L +GE L AT    ++ S GR+  
Sbjct: 3623 AGTDEPRDITVL---RNRQVTLECKSDAVPPPVITWLRNGERLQATPR-VRILSGGRY-- 3676

Query: 853  KAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPE---LQEG 909
                    L++    LGD+ +Y C A+N+ G +       V      +   P+   +   
Sbjct: 3677 --------LQINNADLGDTANYTCVASNIAGKTTREFILTVNVP-PNIKGGPQSLVILLN 3727

Query: 910  QAVVLSCQVHTGVPEGTSYRWYRDGQPLQES-------TSATLRFAAITLTQAGAYHCQA 962
            ++ VL C +  GVP      W +DG  L  +        +  L   +  +T  G Y C A
Sbjct: 3728 KSTVLEC-IAEGVPT-PRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMA 3785

Query: 963  -QAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGD 1021
              A G+    +   + +  S AP    +T +++        L C     P   +      
Sbjct: 3786 TNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQT----TLACEATGIPKPSINWRKNG 3841

Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAML------EDEGVYICEASNTLGQ 1075
             L                 L+V    N+ RL   G+++      +D   Y C  +N  G 
Sbjct: 3842 HL-----------------LNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGD 3884

Query: 1076 ASASADFDAQA-----------VNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQD 1124
               + D   Q            +  +  P         V    + WT +  +L      D
Sbjct: 3885 DKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRG--D 3942

Query: 1125 GQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV----LYAPRNLRLTYL 1180
            G + L + +I +    +  A  Y C       A    R +TL V    +  P+   L  +
Sbjct: 3943 GYRILSSGAIEILATQLNHAGRYTCVAR--NAAGSAHRHVTLHVHEPPVIQPQPSELHVI 4000

Query: 1181 LESHGGQLALVLCTVDSRPPAQLALSHAG-RLLASSTAASVPNTLRLELRGPQPRDEGFY 1239
            L +      L+ C     P   +     G  +  S    +V  +  L++      D G Y
Sbjct: 4001 LNNP----ILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTY 4056

Query: 1240 SCSARSPLGQANTSLELRLEGVRVILAP---EAAVPEGAPITVTCADPAAHAPTLYTWYH 1296
             C A++P G A   ++L ++ V  +++P   E  +    PIT++C       P + TW+ 
Sbjct: 4057 MCVAQNPAGTALGKIKLNVQ-VPPVISPHLKEYVIAVDKPITLSCEADGLPPPDI-TWHK 4114

Query: 1297 NGRWLQEG------PAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAV 1350
            +GR + E        + SL         AG Y+C A +  G+ SS    L V   P+   
Sbjct: 4115 DGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGS-SSTSTKLTVHVPPRIRS 4173

Query: 1351 LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR 1410
                      S A++ C  D  P   +    D  +LA   G ++          A     
Sbjct: 4174 TEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYT----------AEPYGE 4223

Query: 1411 LQVQDVPAGDDT-YVCTAQNLLGSISTIGRLQVEGARVVAE-PG-LDVPEGAALNLSCRL 1467
            L +++V   D   Y C A N  G  +    L V       E PG + + +G  L LSC+ 
Sbjct: 4224 LILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKA 4283

Query: 1468 LGGPGPVGNSTFAWFWNDRRL--HAEPV---PTLAFTHVARAQAGMYHCLAELPTGAAAS 1522
             G P P       W +N+  +  H + V     L    V++  +G Y C AE   G    
Sbjct: 4284 TGIPLP----KLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFV-K 4338

Query: 1523 APVMLRVLYPP--KTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQG 1580
            A   + V  PP  K      ++EP GG   IL+C V  +P  ++  +     +  S    
Sbjct: 4339 AIGFVYVKEPPVFKGDYPSNWIEPLGG-NAILNCEVKGDPTPTIQWNRKGVDIEISHRIR 4397

Query: 1581 APAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTS 1625
                  + +  + N            D G+Y C A+N  G    S
Sbjct: 4398 QLGNGSLAIYGTVN-----------EDAGDYTCVATNEAGVVERS 4431



 Score =  162 bits (411), Expect = 2e-39
 Identities = 366/1673 (21%), Positives = 582/1673 (34%), Gaps = 308/1673 (18%)

Query: 99   NLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDF 158
            +L LK ++  D+G Y+     SE    S      +TV E P+V  +        G+EV  
Sbjct: 575  SLELKSVKFNDAGEYHCMVS-SEGG--SSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSI 631

Query: 159  NCS-TPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRC 217
             CS T Y     + ++ W   D        S ++  T  G   TL +  +      I  C
Sbjct: 632  MCSATGY----PKPKIAWTVND---MFIVGSHRYRMTSDG---TLFIKNAAPKDAGIYGC 681

Query: 218  QLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWL 277
              S +    +    L+   AP   K+++  S   +  G++  + C+ +   P    +KW 
Sbjct: 682  LASNSAGTDKQNSTLRYIEAP---KLMVVQSELLVALGDITVMECKTSGIPP--PQVKWF 736

Query: 278  KDGVRLQTKT--------GVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQ 329
            K  + L+  T        G+L + +    DAG YTC A N  G   +  I+L +    V 
Sbjct: 737  KGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGR-ATGKITLDVGSPPVF 795

Query: 330  V-SPAGPILE-NQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRA---- 383
            +  PA   +E    VTL C         +++    N  +     S +    L T A    
Sbjct: 796  IQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFIL 855

Query: 384  -----DTGFYFCEVQNVHGSERS-GPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVS 437
                 D G Y CE +N  G  +S   V+V     PL  +  +      G    L C++++
Sbjct: 856  NLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLA 915

Query: 438  -EPLA-------TLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEY 489
              P+        + +L    +I   + G                  L I  ++  D GEY
Sbjct: 916  GNPIPERRWIKNSAMLLQNPYITVRSDGS-----------------LHIERVQLQDGGEY 958

Query: 490  KCSATNSLG--NATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYL 547
             C A+N  G  N T+++  H              +EG  VTL C++  +P P     W  
Sbjct: 959  TCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSV--IWSK 1016

Query: 548  NGALL-------HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQ 600
             G L+         G   SL + +    ++G Y C A   ++A        LTV   PR 
Sbjct: 1017 KGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTAT--NTAGYAKRKVQLTVYVRPRV 1074

Query: 601  PTFTTRLDLD---AAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVA------TSLPSGG 651
                  L  D        AG    L C V S PP  +    + ++++      T LPSG 
Sbjct: 1075 FGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGS 1134

Query: 652  GCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQA-TV 710
                       MK+T+               + G+YLC A+N  GN + +   N      
Sbjct: 1135 -----------MKITETRT-----------SDSGMYLCVATNIAGNVTQAVKLNVHVPPK 1172

Query: 711  LAIAPSH-TLQEGTEANLTCNVSREAAGSPAN-FSWFRNGVLW-------AQGPLETVTL 761
            +   P H  +Q G   ++ CN    A G+P    +W + G             P  T+++
Sbjct: 1173 IQRGPKHLKVQVGQRVDIPCN----AQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSI 1228

Query: 762  LPVARTDAALYACRILTEAGAQLSTPVLLSVLYPP-----DRPKLSALLDMGQGHMALFI 816
                 +DA +Y C     AG    T + L V  PP     + P  +   +        F 
Sbjct: 1229 DQATPSDAGIYTCVATNIAGTD-ETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFP 1287

Query: 817  CTVDSRPLALLALFH-GEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYR 875
            C     P   +   H G  L     G  +   G            L +  +   D+G Y 
Sbjct: 1288 CPAKGTPKPTIKWLHNGRELTGREPGISILEDGTL----------LVIASVTPYDNGEYI 1337

Query: 876  CEATNVLGSSNTSLFFQVRGAWV----QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWY 931
            C A N  G++      +V    V    +   +  +   Q   L C+V  G P      WY
Sbjct: 1338 CVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVE-GTP-SPIIMWY 1395

Query: 932  RDGQPLQESTS-------ATLRFAAITLTQAGAYHCQA-QAPGSA----TTSLAAPISLH 979
            +D   + ES++         L+    T   AG Y C+A    G++       +  P ++ 
Sbjct: 1396 KDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTII 1455

Query: 980  VSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSP 1039
             +  P  V++    D        L C+V   P   +      + +      +G P     
Sbjct: 1456 GTNFPNEVSVVLNRDVA------LECQVKGTPFPDIHWFKDGKPLF-----LGDP----- 1499

Query: 1040 RLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVRE 1099
              +V +      L +  A   D+G Y C  SN  G+        A+ + + ++   +++ 
Sbjct: 1500 --NVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGK-------QAKDIKLTIYIPPSIKG 1550

Query: 1100 G-----------QLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS---------IPLPNV 1139
            G            L+ L C   T        TWY+DGQ  + +           + +P  
Sbjct: 1551 GNVTTDISVLINSLIKLEC--ETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRA 1608

Query: 1140 TVRDATSYRCGVG----------------PPGRAPRLSRPITLDVLYAPRNLRLTYLLES 1183
             V D+ +Y C V                 PP     L+ P+   V+ A     LT   ++
Sbjct: 1609 QVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAH---SLTLECKA 1665

Query: 1184 HGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSA 1243
             G    ++    D  P           + A+          +LE+   Q  D G Y C A
Sbjct: 1666 AGNPSPILTWLKDGVP-----------VKANDNIRIEAGGKKLEIMSAQEIDRGQYICVA 1714

Query: 1244 RSPLGQANTSLELRLEGVRVILAPEAAVPEGAPIT------------VTCADPAAHAPTL 1291
             S  G+     E+       +L P A   EG   T            + C    +  PT+
Sbjct: 1715 TSVAGEKEIKYEVD------VLVPPAI--EGGDETSYFIVMVNNLLELDCHVTGSPPPTI 1766

Query: 1292 YTWYHNGRWLQEGP-------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLY 1344
              W  +G+ + E            L    A  ++ G Y C A +  G         +V  
Sbjct: 1767 -MWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKE---FEVTV 1822

Query: 1345 APQDAVLSSFRDSRA---RSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGH 1401
                 + SS    R         +QC  +  P   +    D + + T+ G   + S    
Sbjct: 1823 HVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRV 1882

Query: 1402 VQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAAL 1461
            +Q+A+  L        AG   Y C A N  G      +L V     + + G  + E   +
Sbjct: 1883 LQIAKTLLE------DAG--RYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLV 1934

Query: 1462 N----LSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTL----AFTHVARAQ---AGMYH 1510
            +    L C+  G P PV      W+ ++R L      T         +  AQ   AG+Y 
Sbjct: 1935 SNPVQLECKAAGNPVPV----ITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYK 1990

Query: 1511 CLAELPTGAAASAPVMLRVLYPPKT--PTMMVFVEPEGGLRGILDCRVDSEPLASLT-LH 1567
            C+A + +  A      L+V   P       MV V     +R  L+C     P  SLT L 
Sbjct: 1991 CVA-INSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVR--LECEARGIPAPSLTWLK 2047

Query: 1568 LGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620
             GS + + S          + VL+    L   + + + SD G Y C A N  G
Sbjct: 2048 DGSPVSSFSN--------GLQVLSGGRILA--LTSAQISDTGRYTCVAVNAAG 2090



 Score =  152 bits (385), Expect = 2e-36
 Identities = 356/1584 (22%), Positives = 556/1584 (35%), Gaps = 303/1584 (19%)

Query: 199  LETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELV 258
            L+ +H++    D GR +   ++VA      +  L V   P  +    SP   +++    V
Sbjct: 2350 LKNIHVS----DTGRYVCVAVNVAG-MTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSV 2404

Query: 259  TLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTCQAENG 310
            +LTC+  S  P + SI W KDG        VR+ +   +L L Q    DAG YTC   N 
Sbjct: 2405 SLTCEA-SGIP-LPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNA 2462

Query: 311  VGS---------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCN-TPNEAPSDLRYSW 360
             G          LV P I     + +V+V       E Q+VTL C  T N  P     +W
Sbjct: 2463 AGEERKIFGLSVLVPPHIVGENTLEDVKVK------EKQSVTLTCEVTGNPVP---EITW 2513

Query: 361  YKNHVLLEDAHSH-------TLRLHLATRADTGFYFCEVQNVHG-SERSGPVSVVVNHPP 412
            +K+   L++  +H        L++       TG Y C   +  G   RS  ++V V+ P 
Sbjct: 2514 HKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVS-PT 2572

Query: 413  LTPV--------LTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPR 464
            +  V        +T  L +   LV    C   S P AT+     G     T  +S+ + R
Sbjct: 2573 IAGVGSDGNPEDVTVILNSPTSLV----CEAYSYPPATITWFKDG-----TPLESNRNIR 2623

Query: 465  FSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLL---------I 515
                  P    L+I + +E ++G Y C ATN  G      +       ++         +
Sbjct: 2624 IL----PGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGL 2679

Query: 516  SP-AAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHE-------GPGSSLLLPAASS 567
            SP   ++     +TL C +     P A  SWY +G  L           G +L +  A  
Sbjct: 2680 SPKEVKIKVNNTLTLECEA--YAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQI 2737

Query: 568  TDAGSYHCRARDGHSASGPSSPAVLTVLYPPR-QPTFTTRLDLDAAGAGAGRRGL----- 621
            +D G Y C A   + A        + +  PP  Q  +     LD    G  +  +     
Sbjct: 2738 SDTGRYTCVA--SNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795

Query: 622  -LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPL 680
             L C  ++ PP  L   +KD    TS                 KV   P    ++I    
Sbjct: 2796 SLYCETNAAPPPTL-TWYKDGHPLTSSD---------------KVLILPGGRVLQIPRAK 2839

Query: 681  LEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTE--ANLTCNVSREAAGS 738
            +E+ G Y C A N  G  S           +    +  L E      N +  +   ++GS
Sbjct: 2840 VEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGS 2899

Query: 739  PA-NFSWFRNGVLWAQGPLE-----------TVTLLPVARTDAALYACRILTEAGAQLST 786
            PA   SW ++G    Q  LE            + +L    TD   Y C     AG+    
Sbjct: 2900 PAPRNSWQKDG----QPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGS-AKK 2954

Query: 787  PVLLSVLYPPD--RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQV 844
               L+V  PP    PK   L  +    ++L  C V   P   L+    E  +  +    +
Sbjct: 2955 YFNLNVHVPPSVIGPKSENLTVVVNNFISL-TCEVSGFPPPDLSWLKNEQPIKLNTNTLI 3013

Query: 845  PSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPS- 903
               GR           L++    + D G Y C A N  G S            V V PS 
Sbjct: 3014 VPGGR----------TLQIIRAKVSDGGEYTCIAINQAGESKKKF-----SLTVYVPPSI 3058

Query: 904  ----------PELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST-------SATLR 946
                        ++EG +V L C+ +   P   +  WY++G+ + EST          L 
Sbjct: 3059 KDHDSESLSVVNVREGTSVSLECESNAVPPPVIT--WYKNGRMITESTHVEILADGQMLH 3116

Query: 947  FAAITLTQAGAYHCQA---QAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLL 1003
                 ++  G Y C+A            L   +   +    R V + T+ +        L
Sbjct: 3117 IKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNP-----VTL 3171

Query: 1004 LCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEG 1063
             C     PP  +  L   + +            +S  L V +     +L+I  +   D G
Sbjct: 3172 TCDATGIPPPTIAWLKNHKRIE-----------NSDSLEVRILSGGSKLQIARSQHSDSG 3220

Query: 1064 VYICEASNTLGQAS----ASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTY 1119
             Y C ASN  G+A      S          ++    +V  G+ V L C      P  L  
Sbjct: 3221 NYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNA-NGIPTPL-I 3278

Query: 1120 TWYQDGQQ---------RLDAH--SIPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLD 1167
             W +DG+          R+ A+  ++ +      D   Y C    P G   R+     L+
Sbjct: 3279 QWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRI---FNLN 3335

Query: 1168 VLYAPR---NLRLTYLLESHGGQLALVLCTVDSRPPAQ---------LALSHAGRLLASS 1215
            V   P    N      L +       + C     PP Q         L LS   RLLA+ 
Sbjct: 3336 VYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAG 3395

Query: 1216 TAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP-------- 1267
                +           Q  D   Y+C A +  G  N    L+      + AP        
Sbjct: 3396 QVIRIVRA--------QVSDVAVYTCVASNRAGVDNKHYNLQ------VFAPPNMDNSMG 3441

Query: 1268 --EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLS-------FLVATRAH 1318
              E  V +G+  ++ C      AP++  W  +G+ L      ++S        L A    
Sbjct: 3442 TEEITVLKGSSTSMACITDGTPAPSM-AWLRDGQPLGLDAHLTVSTHGMVLQLLKAETED 3500

Query: 1319 AGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV-----IQCTVDSEP 1373
            +G Y+C A +  G   S+   L+VL  P    ++   +    S+ V     + C     P
Sbjct: 3501 SGKYTCIASNEAG-EVSKHFILKVLEPPH---INGSEEHEEISVIVNNPLELTCIASGIP 3556

Query: 1374 PAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDT--YVCTAQNLL 1431
              ++    DG+ L  +  V +L  G          LR+    V   +DT  Y C A +  
Sbjct: 3557 APKMTWMKDGRPLPQTDQVQTLGGG--------EVLRISTAQV---EDTGRYTCLASSPA 3605

Query: 1432 GSISTIGRLQVEGARVVA---EP-GLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRR 1487
            G       ++V     +A   EP  + V     + L C+    P PV      W  N  R
Sbjct: 3606 GDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV----ITWLRNGER 3661

Query: 1488 LHAEPVPTL----AFTHVARAQAG---MYHCLAELPTGAAASAPVMLRVLYPPKT---PT 1537
            L A P   +     +  +  A  G    Y C+A    G   +   +L V  PP     P 
Sbjct: 3662 LQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAG-KTTREFILTVNVPPNIKGGPQ 3720

Query: 1538 MMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALR 1597
             +V +  +     +L+C  +  P   +T      ++A +  + +  E             
Sbjct: 3721 SLVILLNKS---TVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGF---------- 3767

Query: 1598 VDIEALRPSDQGEYICSASNVLGS 1621
            + I++   +D G Y+C A+N  G+
Sbjct: 3768 LHIQSAHVTDTGRYLCMATNAAGT 3791



 Score =  145 bits (366), Expect = 3e-34
 Identities = 352/1654 (21%), Positives = 589/1654 (35%), Gaps = 263/1654 (15%)

Query: 100  LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159
            L +++ Q  D+G Y     I+E  R     G +      P V  I  P ++    E+  N
Sbjct: 757  LKIQETQDLDAGDYTC-VAINEAGR---ATGKITLDVGSPPV-FIQEPADV--SMEIGSN 809

Query: 160  CSTP-YVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLET--LHMAMSWQDHGRILR 216
             + P YV    +  ++W+  D   ++   S+ F  + +  L T  L +   W        
Sbjct: 810  VTLPCYVQGYPEPTIKWRRLD---NMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYI 866

Query: 217  CQLSVANHRAQSEIHLQVK--YAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSI 274
            C+      + QSE  + V    AP    I +SPS  N++ G+ +TL C + +  P +   
Sbjct: 867  CEAENQFGKIQSETTVTVTGLVAPL---IGISPSVANVIEGQQLTLPCTLLAGNP-IPER 922

Query: 275  KWLKDGVRLQTKT-------GVLHLPQAAWSDAGVYTCQAENGVGSL-VSPPISLHIFMA 326
            +W+K+   L           G LH+ +    D G YTC A N  G+   +  + +H+   
Sbjct: 923  RWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPT 982

Query: 327  EVQVSPAGPILENQTVTLVCNTP-NEAPSDLRYSWYKNHVLLEDAHSH-------TLRLH 378
                      +E   VTL C    N  PS +   W K   L+  + +        +L + 
Sbjct: 983  IQHGQQILSTIEGIPVTLPCKASGNPKPSVI---WSKKGELISTSSAKFSAGADGSLYVV 1039

Query: 379  LATRADTGFYFCEVQNVHG-SERSGPVSVVV------NHPPLTPVLTAFLETQAGLVGIL 431
                 ++G Y C   N  G ++R   ++V V      +   L+      +   AG    L
Sbjct: 1040 SPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTL 1099

Query: 432  HCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKC 491
             C V S P   +  +    ++      S  SPR +     +   ++I +   +DSG Y C
Sbjct: 1100 PCEVKSLPPPIITWAKETQLI------SPFSPRHTFLPSGS---MKITETRTSDSGMYLC 1150

Query: 492  SATNSLGNATSTLDFHANA-ARLLISPA-AEVVEGQAVTLSCRSGLSPTPDARFSWYLNG 549
             ATN  GN T  +  + +   ++   P   +V  GQ V + C +  +P P    +W   G
Sbjct: 1151 VATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLP--VITWSKGG 1208

Query: 550  A-LLHEG------PGSSLLLPAASSTDAGSYHCRAR------DGHSASGPSSPAVLTVLY 596
            + +L +G      P  +L +  A+ +DAG Y C A       +         P  +  L 
Sbjct: 1209 STMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLE 1268

Query: 597  PPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTC 656
            PP   TF  R+        A +R    C     P   ++ LH  R +             
Sbjct: 1269 PPYNTTFQERV--------ANQRIEFPCPAKGTPKPTIKWLHNGRELT------------ 1308

Query: 657  GGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPS 716
             G  P + + +   LL +    P   + G Y+C A N  G              +     
Sbjct: 1309 -GREPGISILEDGTLLVIASVTPY--DNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKE 1365

Query: 717  HTLQEGTEANLTCNVSREAAGSPAN-FSWFRNGV-LWAQGPLETVT------LLPVARTD 768
                     N   N+  E  G+P+    W+++ V +     ++TV       L      D
Sbjct: 1366 QVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPED 1425

Query: 769  AALYACRILTEAGAQ--------LSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVD 820
            A  Y+C+ +  AG          L  P ++   +P +   +S +L+          C V 
Sbjct: 1426 AGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNE---VSVVLNRD----VALECQVK 1478

Query: 821  SRPLALLALF-HGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEAT 879
              P   +  F  G+ L       ++   G+           L ++     D G Y+C  +
Sbjct: 1479 GTPFPDIHWFKDGKPLFLGDPNVELLDRGQV----------LHLKNARRNDKGRYQCTVS 1528

Query: 880  NVLGSSNTSLFF------QVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRD 933
            N  G     +         ++G    V+    +     + L C+   G+P   +  WY+D
Sbjct: 1529 NAAGKQAKDIKLTIYIPPSIKGG--NVTTDISVLINSLIKLECETR-GLPM-PAITWYKD 1584

Query: 934  GQPLQESTSA----------------------TLRFAAITLTQAGAYHCQAQAPGSATTS 971
            GQP+  S+ A                      T   A +  T   ++H     P     +
Sbjct: 1585 GQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGN 1644

Query: 972  LAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGV 1031
            LA P++  V  A    +LT            L C+   +P   L  L             
Sbjct: 1645 LATPLNKQVVIAH---SLT------------LECKAAGNPSPILTWLKD----------- 1678

Query: 1032 GGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQV 1091
            G P  ++  + +       +LEI  A   D G YIC A++  G+     + D        
Sbjct: 1679 GVPVKANDNIRIEAGGK--KLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIE 1736

Query: 1092 WPGAT----VREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ---------RLDAHSIPLPN 1138
                T    V    L+ L C V  + P   T  W +DGQ           L+   + +  
Sbjct: 1737 GGDETSYFIVMVNNLLELDCHVTGSPPP--TIMWLKDGQLIDERDGFKILLNGRKLVIAQ 1794

Query: 1139 VTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSR 1198
              V +   YRC         +    +T+ V    ++  L+  +      +AL  C  +  
Sbjct: 1795 AQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVAL-QCIANGI 1853

Query: 1199 P-PAQLALSHAGRLLASSTAASVPNTLR-LELRGPQPRDEGFYSCSARSPLGQANTSLEL 1256
            P P+   L     +  +     + ++ R L++      D G Y+C A +  G+    ++L
Sbjct: 1854 PNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQL 1913

Query: 1257 R------LEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLS 1310
                   LE    +L     V    P+ + C       P + TWY + R L    + S++
Sbjct: 1914 HVHEPPSLEDAGKMLNETVLVSN--PVQLECKAAGNPVPVI-TWYKDNRLL--SGSTSMT 1968

Query: 1311 FL---------VATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARS 1361
            FL          A  + AG Y C A ++ G  +    +LQV  AP  +  ++       +
Sbjct: 1969 FLNRGQIIDIESAQISDAGIYKCVAINSAGA-TELFYSLQVHVAPSISGSNNMVAVVVNN 2027

Query: 1362 MAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD 1421
               ++C     P   L    DG  +++ S    + SG G +    +A   Q+ D      
Sbjct: 2028 PVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSG-GRILALTSA---QISDT----G 2079

Query: 1422 TYVCTAQNLLG--SISTIGRLQVEGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTF 1479
             Y C A N  G        R+ V    +  E  + V    A+ L C+    P P    T 
Sbjct: 2080 RYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPP----TL 2135

Query: 1480 AWFWNDRRLHAEPVPTL----AFTHVARAQ---AGMYHCLAELPTGAAASAPVMLRVLYP 1532
             W  +   L  +P  ++    +   +  AQ    G Y C A    G        + +  P
Sbjct: 2136 TWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAG-KTEKNYNVNIWVP 2194

Query: 1533 PK---TPTMMVFVEPEGGLRGILDCRVDSEPLASLT-LHLGSRLVASSQPQGAPAEPHIH 1588
            P    +  +      EG L  +L C     P  +L     GS ++  S  +       + 
Sbjct: 2195 PNIGGSDELTQLTVIEGNLISLL-CESSGIPPPNLIWKKKGSPVLTDSMGR-------VR 2246

Query: 1589 VLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
            +L+    L++ I     SD   Y C ASNV G+A
Sbjct: 2247 ILSGGRQLQISI--AEKSDAALYSCVASNVAGTA 2278



 Score =  141 bits (356), Expect = 5e-33
 Identities = 361/1677 (21%), Positives = 590/1677 (35%), Gaps = 290/1677 (17%)

Query: 100  LLLKDLQPEDSGSYNFRFEISEVNRWSDVKG-TLVTVTE--EPRVPTIASPVELLEGTEV 156
            L + +L   D G+Y    E    N++  ++  T VTVT    P +    S   ++EG ++
Sbjct: 852  LFILNLWASDKGTYICEAE----NQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQL 907

Query: 157  DFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKF--------EPTGVGHLETLHMAMSW 208
               C+           L      P R    NS              G  H+E + +    
Sbjct: 908  TLPCT-----------LLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQL---- 952

Query: 209  QDHGRILRCQLSVA--NHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNS 266
            QD G       +VA  N++  S +   +     G +IL      + + G  VTL C+ + 
Sbjct: 953  QDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQIL------STIEGIPVTLPCKASG 1006

Query: 267  SYPAVSSIKWLKDGVRLQTKT--------GVLHLPQAAWSDAGVYTCQAENGVGSL---- 314
            +     S+ W K G  + T +        G L++      ++G Y C A N  G      
Sbjct: 1007 N--PKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKV 1064

Query: 315  -VSPPISLHIFMAEVQVSPAGPI----LENQTVTLVCNTPNEAPSDLRYSWYKNHVLLED 369
             ++  +   +F  +  +S   P+    L  + VTL C   +  P  +  +W K   L+  
Sbjct: 1065 QLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPII--TWAKETQLISP 1122

Query: 370  AH-------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLE 422
                     S ++++     +D+G Y C   N+ G+     V + V+ PP        L+
Sbjct: 1123 FSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQA-VKLNVHVPPKIQRGPKHLK 1181

Query: 423  TQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLE 482
             Q G    + C+    PL  +  S GG  +     D +H       S P+   L I    
Sbjct: 1182 VQVGQRVDIPCNAQGTPLPVITWSKGGSTMLV---DGEHH-----VSNPDGT-LSIDQAT 1232

Query: 483  ETDSGEYKCSATNSLGNATSTLDFHANAARLL--ISPA-----AEVVEGQAVTLSCRSGL 535
             +D+G Y C ATN  G   + +  H      +  + P       E V  Q +   C +  
Sbjct: 1233 PSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKG 1292

Query: 536  SPTPDARFSWYLNGA-LLHEGPGSSLL-----LPAASST--DAGSYHCRARDGHSASGPS 587
            +P P  +  W  NG  L    PG S+L     L  AS T  D G Y C A +    +G +
Sbjct: 1293 TPKPTIK--WLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVN---EAGTT 1347

Query: 588  SPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSL 647
                   ++ P  P    +  +        +   L C V+  P + + + +KD V  T  
Sbjct: 1348 ERKYNLKVHVP--PVIKDKEQVTNVSVLLNQLTNLFCEVEGTP-SPIIMWYKDNVQVTE- 1403

Query: 648  PSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQ 707
                        S  ++      +L++    P  E+ G Y C+A N  G +      +  
Sbjct: 1404 ------------SSTIQTVNNGKILKLFRATP--EDAGRYSCKAINIAGTSQKYFNIDVL 1449

Query: 708  ATVLAIAPSHTLQEGTEANLTCNVSREAAGSP-ANFSWFRNGV-LWAQGPL-------ET 758
                 I  +   +     N    +  +  G+P  +  WF++G  L+   P        + 
Sbjct: 1450 VPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV 1509

Query: 759  VTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICT 818
            + L    R D   Y C +   AG Q +  + L++  PP     +   D+     +L    
Sbjct: 1510 LHLKNARRNDKGRYQCTVSNAAGKQ-AKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLE 1568

Query: 819  VDSRPLALLALF---HGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYR 875
             ++R L + A+     G+ ++++S           QA        L +    + DS +Y 
Sbjct: 1569 CETRGLPMPAITWYKDGQPIMSSS-----------QALYIDKGQYLHIPRAQVSDSATYT 1617

Query: 876  CEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQV---HTGVPEGTS----- 927
            C   NV G++  S         V V   P ++   A  L+ QV   H+   E  +     
Sbjct: 1618 CHVANVAGTAEKSFH-------VDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPS 1670

Query: 928  --YRWYRDGQPLQ-------ESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISL 978
                W +DG P++       E+    L   +      G Y C A +  +    +   + +
Sbjct: 1671 PILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSV-AGEKEIKYEVDV 1729

Query: 979  HVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSS 1038
             V  A      T+        L  L C V   PP  +  L   +L+              
Sbjct: 1730 LVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLI-------------D 1776

Query: 1039 PRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVR 1098
             R    +  N  +L I  A + + G+Y C A+NT G      +     V V V P  T++
Sbjct: 1777 ERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFE-----VTVHVPP--TIK 1829

Query: 1099 EGQLVNLTCLVWTTHPAQL--------TYTWYQDGQQRLDAHS----------IPLPNVT 1140
               L     + +     Q         + TW +D Q    A            + +    
Sbjct: 1830 SSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTL 1889

Query: 1141 VRDATSYRCGVGPPGRAPRLSRPITLDVLYAP------RNLRLTYLLESHGGQLALVLCT 1194
            + DA  Y C       A    + I L V   P      + L  T L+ S+  QL    C 
Sbjct: 1890 LEDAGRYTCVA--TNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLV-SNPVQLE---CK 1943

Query: 1195 VDSRPPAQLALSHAGRLLASSTAASVPNTLRL-ELRGPQPRDEGFYSCSARSPLGQANTS 1253
                P   +      RLL+ ST+ +  N  ++ ++   Q  D G Y C A +  G     
Sbjct: 1944 AAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELF 2003

Query: 1254 LELRLEGVRVILAPE--AAVPEGAPITVTCADPAAHAPTLYTW---------YHNGRWLQ 1302
              L++     I       AV    P+ + C      AP+L TW         + NG  + 
Sbjct: 2004 YSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSL-TWLKDGSPVSSFSNGLQVL 2062

Query: 1303 EGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSM 1362
             G    L+   A  +  G Y+C A +A G +  R   L+V Y P + +      S   S 
Sbjct: 2063 SG-GRILALTSAQISDTGRYTCVAVNAAGEKQ-RDIDLRV-YVPPNIMGEEQNVSVLISQ 2119

Query: 1363 AV-IQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD 1421
            AV + C  D+ PP  L    DG  L    G+           ++ N   L+++D    D 
Sbjct: 2120 AVELLCQSDAIPPPTLTWLKDGHPLLKKPGL----------SISENRSVLKIEDAQVQDT 2169

Query: 1422 -TYVCTAQNLLGSISTIGRLQV------EGARVVAEPGLDVPEGAALNLSCRLLGGPGPV 1474
              Y C A N+ G       + +       G+  + +  L V EG  ++L C   G P P 
Sbjct: 2170 GRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQ--LTVIEGNLISLLCESSGIPPP- 2226

Query: 1475 GNSTFAWFWNDRRLHAEPVPT--------------LAFTHVARAQAGMYHCLAELPTGAA 1520
                  W     +    PV T              L  +   ++ A +Y C+A    G A
Sbjct: 2227 ---NLIW-----KKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTA 2278

Query: 1521 ASAPVMLRVLYPPKT-----PTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVAS 1575
                 +   + P  T     PT ++      G    L+C V   P  ++T       +  
Sbjct: 2279 KKEYNLQVYIRPTITNSGSHPTEIIVTR---GKSISLECEVQGIPPPTVTWMKDGHPLIK 2335

Query: 1576 SQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRA 1632
            ++      E HI          + ++ +  SD G Y+C A NV G         V A
Sbjct: 2336 AKGVEILDEGHI----------LQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHA 2382



 Score =  138 bits (347), Expect = 5e-32
 Identities = 344/1597 (21%), Positives = 547/1597 (34%), Gaps = 267/1597 (16%)

Query: 146  SPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETL--- 202
            S V + EGT V   C +  V              P   +T+       T   H+E L   
Sbjct: 3067 SVVNVREGTSVSLECESNAV--------------PPPVITWYKNGRMITESTHVEILADG 3112

Query: 203  ---HMAMSW-QDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILP--GE 256
               H+  +   D G+ +   ++VA  R     HL V Y P  ++    P    I+     
Sbjct: 3113 QMLHIKKAEVSDTGQYVCRAINVAG-RDDKNFHLNV-YVPPSIE---GPEREVIVETISN 3167

Query: 257  LVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTCQ 306
             VTLTC      P   +I WLK+  R++    +          L + ++  SD+G YTC 
Sbjct: 3168 PVTLTCDATGIPPP--TIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCI 3225

Query: 307  AENGVG--------SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRY 358
            A N  G        S+  PP      +A  ++     +L  + V LVCN  N  P+ L  
Sbjct: 3226 ASNMEGKAQKYYFLSIQVPPS-----VAGAEIPSDVSVLLGENVELVCNA-NGIPTPL-I 3278

Query: 359  SWYKN---------HVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSE-RSGPVSVVV 408
             W K+           +   A+  TL ++ A  +DTG Y C   N  G E R   ++V V
Sbjct: 3279 QWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYV 3338

Query: 409  NHPPLTPVLTAFLETQAGLVGILHCSVVSEPLAT-------------LVLSHGGHILAST 455
                 TP +    +    L+ ++  S+  E  AT             L L    HI    
Sbjct: 3339 -----TPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLA 3393

Query: 456  SGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG--NATSTLDFHA--NAA 511
            +G                  + I   + +D   Y C A+N  G  N    L   A  N  
Sbjct: 3394 AGQV----------------IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMD 3437

Query: 512  RLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGA-------LLHEGPGSSLLLPA 564
              + +    V++G + +++C +  +P P    +W  +G        L     G  L L  
Sbjct: 3438 NSMGTEEITVLKGSSTSMACITDGTPAPS--MAWLRDGQPLGLDAHLTVSTHGMVLQLLK 3495

Query: 565  ASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLC 624
            A + D+G Y C A   + A   S   +L VL PP         ++           L L 
Sbjct: 3496 AETEDSGKYTCIA--SNEAGEVSKHFILKVLEPPHINGSEEHEEISVIV----NNPLELT 3549

Query: 625  RVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEE 684
             + S  PA      KD      LP      T GG            +LR+      +E+ 
Sbjct: 3550 CIASGIPAPKMTWMKD---GRPLPQTDQVQTLGG----------GEVLRISTAQ--VEDT 3594

Query: 685  GLYLCEASNALGNASTSATFNGQATVLAIAPSH----TLQEGTEANLTCNVSREAAGSPA 740
            G Y C AS+  G+                        T+    +  L C   +  A  P 
Sbjct: 3595 GRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLEC---KSDAVPPP 3651

Query: 741  NFSWFRNGVLWAQGPLETVTLLPVART---------DAALYACRILTEAGAQLSTPVLLS 791
              +W RNG      P   V +L   R          D A Y C + +    + +   +L+
Sbjct: 3652 VITWLRNGERLQATP--RVRILSGGRYLQINNADLGDTANYTC-VASNIAGKTTREFILT 3708

Query: 792  VLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQ 851
            V  PP+       L +      +  C  +  P   +       +LA +       H R+ 
Sbjct: 3709 VNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGN-------HARYS 3761

Query: 852  AKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE--- 908
                     L ++   + D+G Y C ATN  G+    +  QV      ++P P       
Sbjct: 3762 ILENGF---LHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVP-PSIAPGPTNMTVIV 3817

Query: 909  GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQES---------TSATLRFAAITLTQAGAYH 959
                 L+C+  TG+P+  S  W ++G  L            +S +L   + ++     Y 
Sbjct: 3818 NVQTTLACEA-TGIPK-PSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYE 3875

Query: 960  C---QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDP-PAQL 1015
            C           T  L   +   ++  P    +T           ++ C     P P+  
Sbjct: 3876 CTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPA------VITCTASGVPFPSIH 3929

Query: 1016 RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQ 1075
               +G RL+         P G   R+  + A     +EI    L   G Y C A N  G 
Sbjct: 3930 WTKNGIRLL---------PRGDGYRILSSGA-----IEILATQLNHAGRYTCVARNAAGS 3975

Query: 1076 ASASADFDAQAVNVQVWPGATVREGQLVNLTCLVW-TTHPAQLTYTWYQDG--------- 1125
            A            V + P  +     L N   L    T       TW ++G         
Sbjct: 3976 AHRHVTLHVHEPPV-IQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRN 4034

Query: 1126 QQRLDAHSIPLPNVTVRDATSYRC-GVGPPGRA-PRLSRPITLDVLYAPRNLRLTYLLES 1183
               L +  + +      DA +Y C    P G A  ++   + +  + +P        ++ 
Sbjct: 4035 HAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDK 4094

Query: 1184 HGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSA 1243
                   + C  D  PP  +     GR +  S    V ++  L++   QP D G Y+C A
Sbjct: 4095 P----ITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMA 4150

Query: 1244 RSPLGQANTSLELRLEGVRVILAPEA--AVPEGAPITVTCADPAAHAPTLYTWYHN---- 1297
             +  G ++TS +L +     I + E    V E +   + C       P +  W  +    
Sbjct: 4151 ANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAI-NWKKDNVLL 4209

Query: 1298 ----GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSS 1353
                G++  E P   L         +G Y+C A +A G   +   +L V   P    L  
Sbjct: 4210 ANLLGKYTAE-PYGELILENVVLEDSGFYTCVANNAAG-EDTHTVSLTVHVLPTFTELPG 4267

Query: 1354 FRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQV 1413
                       + C     P  +L  + +  ++          S  GH ++     R+  
Sbjct: 4268 DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPA-----HFDSVNGHSELVIE--RVSK 4320

Query: 1414 QDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVA---EPGLDVPEGAALNLSCRLLGG 1470
            +D      TYVCTA+N +G +  IG + V+   V           P G    L+C + G 
Sbjct: 4321 ED----SGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGD 4376

Query: 1471 PGPVGNSTFAW------FWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAP 1524
            P P    T  W           R+      +LA        AG Y C+A    G    + 
Sbjct: 4377 PTP----TIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERS- 4431

Query: 1525 VMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAE 1584
            + L +  PP      V      G + IL+C+   EP  ++T         S Q      +
Sbjct: 4432 MSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITW--------SRQGHSISWD 4483

Query: 1585 PHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621
              ++VL++ +    D +     D  E+ C A N++GS
Sbjct: 4484 DRVNVLSNNSLYIADAQ---KEDTSEFECVARNLMGS 4517



 Score =  134 bits (337), Expect = 8e-31
 Identities = 337/1500 (22%), Positives = 518/1500 (34%), Gaps = 233/1500 (15%)

Query: 245  LSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV--------LHLPQAA 296
            LSP    I     +TL C+  +   A  S+ W KDG  L++   V        L + +A 
Sbjct: 2679 LSPKEVKIKVNNTLTLECEAYAIPSA--SLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQ 2736

Query: 297  WSDAGVYTCQAENGVG--------SLVSPPISLHIF-----MAEVQVSPAGPILENQTVT 343
             SD G YTC A N  G        ++  PP    ++     +   +   A  ++ N  ++
Sbjct: 2737 ISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPIS 2796

Query: 344  LVCNTPNEAPSDLRYSWYKNHVLLEDAHS-------HTLRLHLATRADTGFYFCEVQNVH 396
            L C T    P  L  +WYK+   L  +           L++  A   D G Y C   N  
Sbjct: 2797 LYCETNAAPPPTL--TWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEA 2854

Query: 397  GSERSGPVSVVVNHPPLTPVLTAFLETQAGLV----GILHCSVVSEPLATLVLSHGGHIL 452
            G E S    V V  PP+     + L  +  ++     ++ C     P         G  L
Sbjct: 2855 G-EDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPL 2913

Query: 453  ASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR 512
                 + DH    S     N   L+I + + TD G Y C A N+ G+A    + + +   
Sbjct: 2914 L----EDDHHKFLS-----NGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPP 2964

Query: 513  LLISPAAE---VVEGQAVTLSCRSGLSPTPDARFSWY-------LNGALLHEGPGSSLLL 562
             +I P +E   VV    ++L+C     P PD   SW        LN   L    G +L +
Sbjct: 2965 SVIGPKSENLTVVVNNFISLTCEVSGFPPPD--LSWLKNEQPIKLNTNTLIVPGGRTLQI 3022

Query: 563  PAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLL 622
              A  +D G Y C A   + A        LTV  PP      +   L       G    L
Sbjct: 3023 IRAKVSDGGEYTCIAI--NQAGESKKKFSLTVYVPPSIKDHDSE-SLSVVNVREGTSVSL 3079

Query: 623  LCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLE 682
             C  ++ PP  +      R++                S  +++     +L ++     + 
Sbjct: 3080 ECESNAVPPPVITWYKNGRMITE--------------STHVEILADGQMLHIK--KAEVS 3123

Query: 683  EEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEAN---LTCNVSREAAG-S 738
            + G Y+C A N  G    +   N         P   +   T +N   LTC    +A G  
Sbjct: 3124 DTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTC----DATGIP 3179

Query: 739  PANFSWFRNGV-LWAQGPLETVTL-----LPVAR---TDAALYACRILTEAGAQLSTPVL 789
            P   +W +N   +     LE   L     L +AR   +D+  Y C I +    +      
Sbjct: 3180 PPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTC-IASNMEGKAQKYYF 3238

Query: 790  LSVLYPPD--RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSH 847
            LS+  PP     ++ + + +  G     +C  +  P  L+             G  + S 
Sbjct: 3239 LSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKD--------GKPIASG 3290

Query: 848  GRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQ 907
               + +  AN   L +      D+G Y C ATN  G  +     ++    V V+P+    
Sbjct: 3291 ETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEED-----RIFNLNVYVTPTIRGN 3345

Query: 908  EGQAVVLSCQVHTGV-----PEGT---SYRWYRDGQPLQEST-------SATLRFAAITL 952
            + +A  L   V T +       GT      W ++G PL  S+          +R     +
Sbjct: 3346 KDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQV 3405

Query: 953  TQAGAYHCQAQAPGSA-----TTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRV 1007
            +    Y C A              + AP ++  S     +T+     T       + C  
Sbjct: 3406 SDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTS------MACIT 3459

Query: 1008 DSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYIC 1067
            D  P   +  L             G P G     H+ V+ + + L++  A  ED G Y C
Sbjct: 3460 DGTPAPSMAWLRD-----------GQPLGLD--AHLTVSTHGMVLQLLKAETEDSGKYTC 3506

Query: 1068 EASNTLGQASASADFDAQAVNVQVWPGATVRE--GQLVN----LTCLVWTTHPAQLTYTW 1121
             ASN  G+   S  F  + +      G+   E    +VN    LTC+  +  PA    TW
Sbjct: 3507 IASNEAGE--VSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIA-SGIPAP-KMTW 3562

Query: 1122 YQDGQ--------QRLDAHSI-PLPNVTVRDATSYRCGVGPPG------RAPRLSRPITL 1166
             +DG+        Q L    +  +    V D   Y C    P          R+  P  +
Sbjct: 3563 MKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNI 3622

Query: 1167 DVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLA-LSHAGRLLASSTAASVPNTLR 1225
                 PR++ +         Q+ L  C  D+ PP  +  L +  RL A+     +     
Sbjct: 3623 AGTDEPRDITVL-----RNRQVTLE-CKSDAVPPPVITWLRNGERLQATPRVRILSGGRY 3676

Query: 1226 LELRGPQPRDEGFYSCSARSPLGQANTSLELRLE-GVRVILAPEAAVPEGAPITV-TCAD 1283
            L++      D   Y+C A +  G+      L +     +   P++ V      TV  C  
Sbjct: 3677 LQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIA 3736

Query: 1284 PAAHAPTLYTWYHNGRWLQEGPA----ASLSFLVATRAH---AGAYSCQAQDAQGTRSSR 1336
                 P + TW  +G  L    A        FL    AH    G Y C A +A GT   R
Sbjct: 3737 EGVPTPRI-TWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGT-DRR 3794

Query: 1337 PAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHS-- 1394
               LQV   P  A   +           + C     P   +    +G +L      +S  
Sbjct: 3795 RIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYR 3854

Query: 1395 -LASGTGHVQVARNALRLQVQDVPAGDD--TYVCTAQNLLGSISTIGRLQVEGARVVAEP 1451
             L+SG+             V   P+ DD  TY CT  N  G       L V+    +A+ 
Sbjct: 3855 LLSSGS------------LVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADE 3902

Query: 1452 GLD--VPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRL----HAEPVPTLAFTHVARAQ 1505
              D  V + A   ++C   G P P    +  W  N  RL        + +     +   Q
Sbjct: 3903 PTDFLVTKHAPAVITCTASGVPFP----SIHWTKNGIRLLPRGDGYRILSSGAIEILATQ 3958

Query: 1506 ---AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLA 1562
               AG Y C+A    G +A   V L V  PP        +        +L C     P  
Sbjct: 3959 LNHAGRYTCVARNAAG-SAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSP 4017

Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
             +T       V +S           H +     L++   A+R  D G Y+C A N  G+A
Sbjct: 4018 FITWQKEGINVNTSGRN--------HAVLPSGGLQIS-RAVR-EDAGTYMCVAQNPAGTA 4067



 Score =  133 bits (335), Expect = 1e-30
 Identities = 317/1508 (21%), Positives = 545/1508 (36%), Gaps = 254/1508 (16%)

Query: 243  ILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW--------LKDGVRLQTKTGV-LHLP 293
            ++  P+   + PGE   LTC + S+     ++ W        L +  R++T   + L L 
Sbjct: 522  VIQVPNNVTVTPGERAVLTCLIISAVDY--NLTWQRNDRDVRLAEPARIRTLANLSLELK 579

Query: 294  QAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPIL-ENQT------VTLVC 346
               ++DAG Y C   +  GS  +      +F+  VQ  P   ++ +NQ+      V+++C
Sbjct: 580  SVKFNDAGEYHCMVSSEGGSSAAS-----VFLT-VQEPPKVTVMPKNQSFTGGSEVSIMC 633

Query: 347  NTPNEAPSDLRYSWYKNHVLLEDAHSH------TLRLHLATRADTGFYFCEVQNVHGSER 400
            +        +  +W  N + +  +H +      TL +  A   D G Y C   N  G+++
Sbjct: 634  SATGYPKPKI--AWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDK 691

Query: 401  SGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSD 460
                   +  P L  V +  L    G + ++ C     P   +             GD +
Sbjct: 692  QNSTLRYIEAPKLMVVQSELL-VALGDITVMECKTSGIPPPQVKWF---------KGDLE 741

Query: 461  HSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAE 520
              P       P    L+I++ ++ D+G+Y C A N  G AT  +     +  + I   A+
Sbjct: 742  LRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPAD 801

Query: 521  VVE--GQAVTLSCRSGLSPTPDAR---------FSWYLNGALLHEGPGSSLLLPAASSTD 569
            V    G  VTL C     P P  +         FS   + + + +    +L +    ++D
Sbjct: 802  VSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASD 861

Query: 570  AGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSD 629
             G+Y C A +        +   +T L  P        +    A    G++  L C + + 
Sbjct: 862  KGTYICEAENQFGKIQSETTVTVTGLVAP-----LIGISPSVANVIEGQQLTLPCTLLAG 916

Query: 630  PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLC 689
             P   +   K+  +                +P + V    +L    I    L++ G Y C
Sbjct: 917  NPIPERRWIKNSAMLLQ-------------NPYITVRSDGSL---HIERVQLQDGGEYTC 960

Query: 690  EASNALG--NASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSP-ANFSWFR 746
             ASN  G  N +TS   +   T+       +  EG    L C    +A+G+P  +  W +
Sbjct: 961  VASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPC----KASGNPKPSVIWSK 1016

Query: 747  NGVL-------WAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPP--- 796
             G L       ++ G   ++ ++     ++  Y C     AG      V L+V   P   
Sbjct: 1017 KGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAG-YAKRKVQLTVYVRPRVF 1075

Query: 797  --------DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHG 848
                    D+P   ++L    G      C V S P  ++       L++    P  P H 
Sbjct: 1076 GDQRGLSQDKPVEISVL---AGEEVTLPCEVKSLPPPIITWAKETQLIS----PFSPRH- 1127

Query: 849  RFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR-GAWVQVSPSP-EL 906
                     S  +++ E    DSG Y C ATN+ G+   ++   V     +Q  P   ++
Sbjct: 1128 -----TFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKV 1182

Query: 907  QEGQAVVLSCQVH-TGVPEGTSYRWYR-------DGQPLQESTSATLRFAAITLTQAGAY 958
            Q GQ V + C    T +P  T   W +       DG+    +   TL     T + AG Y
Sbjct: 1183 QVGQRVDIPCNAQGTPLPVIT---WSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIY 1239

Query: 959  HCQA-QAPGSATTSLAAPISLHVSYAPRHVTL-----TTLMDTGPGRLGLLLCRVDSDPP 1012
             C A    G+  T     I+LHV   P    L     TT  +    +     C     P 
Sbjct: 1240 TCVATNIAGTDETE----ITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPK 1295

Query: 1013 AQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNT 1072
              ++ LH  R +     G+   E  +  +  +V P             D G YIC A N 
Sbjct: 1296 PTIKWLHNGRELTGREPGISILEDGTLLVIASVTP------------YDNGEYICVAVNE 1343

Query: 1073 LGQASASADFDAQAVNV----QVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQR 1128
             G      +       V    +     +V   QL NL C V  T P+ +   WY+D  Q 
Sbjct: 1344 AGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGT-PSPI-IMWYKDNVQV 1401

Query: 1129 LDAHSIPLPN---------VTVRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLT 1178
             ++ +I   N          T  DA  Y C  +   G + +      +DVL  P     T
Sbjct: 1402 TESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKY---FNIDVLVPP-----T 1453

Query: 1179 YLLESHGGQLALVL-------CTVDSRPPAQLALSHAGR--LLASSTAASVPNTLRLELR 1229
             +  +   ++++VL       C V   P   +     G+   L       +     L L+
Sbjct: 1454 IIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLK 1513

Query: 1230 GPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVI----LAPEAAVPEGAPITVTCADPA 1285
              +  D+G Y C+  +  G+    ++L +     I    +  + +V   + I + C    
Sbjct: 1514 NARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRG 1573

Query: 1286 AHAPTLYTWYHNGRWLQEGPAASL----SFLVATRAH---AGAYSCQAQDAQGTRSSRPA 1338
               P + TWY +G+ +     A       +L   RA    +  Y+C   +  GT + +  
Sbjct: 1574 LPMPAI-TWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGT-AEKSF 1631

Query: 1339 ALQVLYAPQ-DAVLSSFRDSR---ARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHS 1394
             + V   P  +  L++  + +   A S+  ++C     P   L    DG  +  +  +  
Sbjct: 1632 HVDVYVPPMIEGNLATPLNKQVVIAHSL-TLECKAAGNPSPILTWLKDGVPVKANDNIRI 1690

Query: 1395 LASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLD 1454
             A G       +    +  Q++  G   Y+C A ++ G      + +V+   V+  P ++
Sbjct: 1691 EAGG-------KKLEIMSAQEIDRGQ--YICVATSVAGEKEI--KYEVD---VLVPPAIE 1736

Query: 1455 ---------VPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTH----V 1501
                     V     L L C + G P P    T  W  + + +       +        +
Sbjct: 1737 GGDETSYFIVMVNNLLELDCHVTGSPPP----TIMWLKDGQLIDERDGFKILLNGRKLVI 1792

Query: 1502 ARAQ---AGMYHCLAELPTGAAASAPVMLRVLYPPK------TPTMMVFVEPEGGLRGIL 1552
            A+AQ    G+Y C+A   T         + V  PP       +  ++V  +P       L
Sbjct: 1793 AQAQVSNTGLYRCMA-ANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVA-----L 1846

Query: 1553 DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612
             C  +  P  S+T       +   QP    A+ ++ + +S   L++    L   D G Y 
Sbjct: 1847 QCIANGIPNPSIT------WLKDDQPVNT-AQGNLKIQSSGRVLQIAKTLL--EDAGRYT 1897

Query: 1613 CSASNVLG 1620
            C A+N  G
Sbjct: 1898 CVATNAAG 1905



 Score =  133 bits (334), Expect = 2e-30
 Identities = 283/1247 (22%), Positives = 453/1247 (36%), Gaps = 234/1247 (18%)

Query: 213  RILRCQLS-------VANHRA---QSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTC 262
            RI+R Q+S       VA++RA       +LQV +AP  +   +      +L G   ++ C
Sbjct: 3399 RIVRAQVSDVAVYTCVASNRAGVDNKHYNLQV-FAPPNMDNSMGTEEITVLKGSSTSMAC 3457

Query: 263  QVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSL 314
             +    PA  S+ WL+DG        + + T   VL L +A   D+G YTC A N  G  
Sbjct: 3458 -ITDGTPA-PSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGE- 3514

Query: 315  VSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNE---------APSDLRYSWYKNHV 365
                +S H  +  ++        E++ ++++ N P E         AP   + +W K+  
Sbjct: 3515 ----VSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAP---KMTWMKDGR 3567

Query: 366  LLEDAHS-------HTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPV-- 416
             L              LR+  A   DTG Y C   +  G +    +  V   P +     
Sbjct: 3568 PLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDE 3627

Query: 417  ---LTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNS 473
               +T     Q      L C   + P   +     G  L +T       PR    SG   
Sbjct: 3628 PRDITVLRNRQV----TLECKSDAVPPPVITWLRNGERLQAT-------PRVRILSGGRY 3676

Query: 474  LRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAA-RLLISPAAEVVE-GQAVTLSC 531
            L++   DL +T    Y C A+N  G  T       N    +   P + V+   ++  L C
Sbjct: 3677 LQINNADLGDT--ANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLEC 3734

Query: 532  RSGLSPTPDARFSWYLNGALLHEG-------PGSSLLLPAASSTDAGSYHCRARDGHSAS 584
             +   PTP  R +W  +GA+L              L + +A  TD G Y C A +     
Sbjct: 3735 IAEGVPTP--RITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATN----- 3787

Query: 585  GPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVA 644
                                      AAG    R  L +    S  P    +      V 
Sbjct: 3788 --------------------------AAGTDRRRIDLQVHVPPSIAPGPTNM-----TVI 3816

Query: 645  TSLPSGGGCSTCGGCSPRMKVTKAPNLLRVE---------------IHNPLLEEEGLYLC 689
             ++ +   C   G   P +   K  +LL V+               I +P +++   Y C
Sbjct: 3817 VNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYEC 3876

Query: 690  EASNALGNASTSATFNGQATV-LAIAPSHTL-QEGTEANLTCNVSREAAGSP-ANFSWFR 746
              +N  G+   +     Q    +A  P+  L  +   A +TC     A+G P  +  W +
Sbjct: 3877 TVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCT----ASGVPFPSIHWTK 3932

Query: 747  NGV----------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPP 796
            NG+          + + G +E   +L      A  Y C +   A       V L V  PP
Sbjct: 3933 NGIRLLPRGDGYRILSSGAIE---ILATQLNHAGRYTC-VARNAAGSAHRHVTLHVHEPP 3988

Query: 797  DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEA 856
                  + L +   +  L  C     P   +             G  V + GR  A   +
Sbjct: 3989 VIQPQPSELHVILNNPILLPCEATGTPSPFITW--------QKEGINVNTSGRNHAVLPS 4040

Query: 857  NSLKLE--VRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSP--SPELQE---- 908
              L++   VRE    D+G+Y C A N  G++   +   V     QV P  SP L+E    
Sbjct: 4041 GGLQISRAVRE----DAGTYMCVAQNPAGTALGKIKLNV-----QVPPVISPHLKEYVIA 4091

Query: 909  -GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQES------TSATLRFAAITLTQAGAYHCQ 961
              + + LSC+   G+P      W++DG+ + ES      +S +L+ A +    AG Y C 
Sbjct: 4092 VDKPITLSCEAD-GLPP-PDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCM 4149

Query: 962  A-QAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020
            A    GS++TS    +++HV   PR  +             +L C  D  P   +     
Sbjct: 4150 AANVAGSSSTS--TKLTVHVP--PRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKD 4205

Query: 1021 DRLVASTL-QGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASAS 1079
            + L+A+ L +    P G               L +   +LED G Y C A+N  G+    
Sbjct: 4206 NVLLANLLGKYTAEPYGE--------------LILENVVLEDSGFYTCVANNAAGE---- 4247

Query: 1080 ADFDAQAVNVQVWPGAT-------VREGQLVNLTCLVWTTHPAQLTYTWYQD----GQQR 1128
             D    ++ V V P  T       + +G+ + L+C        +LT+T+  +        
Sbjct: 4248 -DTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDS 4306

Query: 1129 LDAHS-IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY---LLESH 1184
            ++ HS + +  V+  D+ +Y C       +    + I    +  P   +  Y    +E  
Sbjct: 4307 VNGHSELVIERVSKEDSGTYVC---TAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPL 4363

Query: 1185 GGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSAR 1244
            GG  A++ C V   P   +  +  G  +  S          L + G    D G Y+C A 
Sbjct: 4364 GGN-AILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVAT 4422

Query: 1245 SPLGQANTSLELRLEGVRVI-LAP-EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQ 1302
            +  G    S+ L L+   +I L P E  +  G  I + C       PT+ TW   G  + 
Sbjct: 4423 NEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTI-TWSRQGHSIS 4481

Query: 1303 EGPAA------SLSFLVATRAHAGAYSCQAQDAQGTRSSR-PAALQV 1342
                       SL    A +     + C A++  G+   R P  +QV
Sbjct: 4482 WDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQV 4528



 Score =  124 bits (310), Expect = 1e-27
 Identities = 233/1018 (22%), Positives = 361/1018 (35%), Gaps = 170/1018 (16%)

Query: 236  YAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV------ 289
            + P  +     P    +L    VTL C+ ++  P V  I WL++G RLQ    V      
Sbjct: 3617 HVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV--ITWLRNGERLQATPRVRILSGG 3674

Query: 290  --LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSP---AGP----ILENQ 340
              L +  A   D   YTC A N  G           F+  V V P    GP    IL N+
Sbjct: 3675 RYLQINNADLGDTANYTCVASNIAGKTTRE------FILTVNVPPNIKGGPQSLVILLNK 3728

Query: 341  TVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHT-------LRLHLATRADTGFYFCEVQ 393
            +  L C    E     R +W K+  +L   H+         L +  A   DTG Y C   
Sbjct: 3729 STVLECIA--EGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMAT 3786

Query: 394  NVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILA 453
            N  G++R   + + V+ PP        +     +   L C     P  ++     GH+L 
Sbjct: 3787 NAAGTDRRR-IDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLN 3845

Query: 454  STSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARL 513
                 + +    SG+       L I      D+  Y+C+ TN  G+   T+D        
Sbjct: 3846 VDQNQNSYRLLSSGS-------LVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPS 3898

Query: 514  LISPAAE--VVEGQAVTLSCRSGLSPTPDARFSWYLNGA-LLHEGPGSSLL------LPA 564
            +     +  V +     ++C +   P P     W  NG  LL  G G  +L      + A
Sbjct: 3899 IADEPTDFLVTKHAPAVITCTASGVPFPSIH--WTKNGIRLLPRGDGYRILSSGAIEILA 3956

Query: 565  ASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLC 624
                 AG Y C AR+  +A        L V  PP      + L +           LL C
Sbjct: 3957 TQLNHAGRYTCVARN--AAGSAHRHVTLHVHEPPVIQPQPSELHVIL-----NNPILLPC 4009

Query: 625  RVDSDPPARLQLLHKDRVVATS------LPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHN 678
                 P   +    +   V TS      LPSGG                      ++I  
Sbjct: 4010 EATGTPSPFITWQKEGINVNTSGRNHAVLPSGG----------------------LQISR 4047

Query: 679  PLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAG- 737
             + E+ G Y+C A N  G A      N Q  V  +   H  +     +    +S EA G 
Sbjct: 4048 AVREDAGTYMCVAQNPAGTALGKIKLNVQ--VPPVISPHLKEYVIAVDKPITLSCEADGL 4105

Query: 738  SPANFSWFRNGV---------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPV 788
             P + +W ++G          + + G L+   + P    DA  Y C     AG+  ST  
Sbjct: 4106 PPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQP---GDAGHYTCMAANVAGSS-STST 4161

Query: 789  LLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHG 848
             L+V  PP          + +   A+  C  D  P   +       LLA  LG       
Sbjct: 4162 KLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLG------- 4214

Query: 849  RFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN--TSLFFQVRGAWVQVSPSPEL 906
            ++ A+      +L +  + L DSG Y C A N  G      SL   V   + ++     L
Sbjct: 4215 KYTAEPYG---ELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSL 4271

Query: 907  QEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT-----LRFAAITLTQAGAYHCQ 961
             +G+ + LSC+  TG+P      W  +   +     +      L    ++   +G Y C 
Sbjct: 4272 NKGEQLRLSCKA-TGIPL-PKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCT 4329

Query: 962  AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP-GRLGLLLCRVDSDPPAQLRLLHG 1020
            A+   ++   + A   ++V   P            P G   +L C V  DP   ++    
Sbjct: 4330 AE---NSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRK 4386

Query: 1021 --DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASA 1078
              D  ++  ++ +G   GS              L I+G + ED G Y C A+N  G    
Sbjct: 4387 GVDIEISHRIRQLGN--GS--------------LAIYGTVNEDAGDYTCVATNEAGVVER 4430

Query: 1079 SADFDAQAVN-VQVWPGATV-REGQLVNLTCLVWTTHPAQLTYTWYQDGQ--------QR 1128
            S     Q+   + + P  TV   G  + L C    T   Q T TW + G           
Sbjct: 4431 SMSLTLQSPPIITLEPVETVINAGGKIILNC--QATGEPQPTITWSRQGHSISWDDRVNV 4488

Query: 1129 LDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGG 1186
            L  +S+ + +    D + + C          ++R +   VL     +R+  +++ HGG
Sbjct: 4489 LSNNSLYIADAQKEDTSEFEC----------VARNLMGSVL-----VRVPVIVQVHGG 4531



 Score =  119 bits (299), Expect = 2e-26
 Identities = 186/822 (22%), Positives = 304/822 (36%), Gaps = 99/822 (12%)

Query: 855  EANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR--GAWVQVSPSPELQEGQAV 912
            E+ S+ L++ ++ L D G Y C A +  G+     FF V      +QV  +  +  G+  
Sbjct: 478  ESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERA 537

Query: 913  VLSCQVHTGVPEGTSY----RWYRDGQPLQESTSA--TLRFAAITLTQAGAYHCQAQAPG 966
            VL+C + + V    ++    R  R  +P +  T A  +L   ++    AG YHC   + G
Sbjct: 538  VLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEG 597

Query: 967  SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVAS 1026
                S AA + L V   P+   +        G    ++C     P  ++     D  +  
Sbjct: 598  G---SSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVG 654

Query: 1027 TLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLG---QASASADFD 1083
            + +     +G+              L I  A  +D G+Y C ASN+ G   Q S     +
Sbjct: 655  SHRYRMTSDGT--------------LFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIE 700

Query: 1084 AQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQ-DGQQRLDAHSIPLPNVTV- 1141
            A  + V V     V  G +  + C      P Q+   W++ D + R     I  P + + 
Sbjct: 701  APKLMV-VQSELLVALGDITVMECKTSGIPPPQV--KWFKGDLELRPSTFLIIDPLLGLL 757

Query: 1142 -------RDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLC 1193
                    DA  Y C  +   GRA   +  ITLDV   P  ++    +    G    + C
Sbjct: 758  KIQETQDLDAGDYTCVAINEAGRA---TGKITLDVGSPPVFIQEPADVSMEIGSNVTLPC 814

Query: 1194 TVDSRPPAQLALSHAGRLLASSTAASVPNTLRLE-----LRGPQPRDEGFYSCSARSPLG 1248
             V   P   +       +   S   SV +  +L      +      D+G Y C A +  G
Sbjct: 815  YVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFG 874

Query: 1249 QANTSLELRLEGV---RVILAPEAA-VPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEG 1304
            +  +   + + G+    + ++P  A V EG  +T+ C   A +      W  N   L + 
Sbjct: 875  KIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQN 934

Query: 1305 P------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSR 1358
            P        SL          G Y+C A +  GT +++  ++ V   P          + 
Sbjct: 935  PYITVRSDGSLHIERVQLQDGGEYTCVASNVAGT-NNKTTSVVVHVLPTIQHGQQILSTI 993

Query: 1359 ARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPA 1418
                  + C     P   +  S  G++++TSS   S A   G + V            P 
Sbjct: 994  EGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFS-AGADGSLYVVS----------PG 1042

Query: 1419 GDDT--YVCTAQNLLGSISTIGRLQV----------EGARVVAEPGLDVPEGAALNLSCR 1466
            G+++  YVCTA N  G      +L V           G        + V  G  + L C 
Sbjct: 1043 GEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCE 1102

Query: 1467 LLGGPGPV---GNSTFAWFWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASA 1523
            +   P P+      T        R    P  ++  T    + +GMY C+A    G    A
Sbjct: 1103 VKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQA 1162

Query: 1524 PVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHL-GSRLVASSQPQGAP 1582
             V L V  PPK       ++ + G R  + C     PL  +T    GS ++   +     
Sbjct: 1163 -VKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGE----- 1216

Query: 1583 AEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSAST 1624
                 H +++P+   + I+   PSD G Y C A+N+ G+  T
Sbjct: 1217 -----HHVSNPDG-TLSIDQATPSDAGIYTCVATNIAGTDET 1252



 Score =  113 bits (283), Expect = 1e-24
 Identities = 284/1363 (20%), Positives = 495/1363 (36%), Gaps = 228/1363 (16%)

Query: 367  LEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAG 426
            L+++ S  L +   T +D GFY C   +  G+ R+     V   PP+  V      T  G
Sbjct: 476  LKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVT-PG 534

Query: 427  LVGILHCSVVSEPLATLVLSHGGHILASTSGDSD---HSPRFSGTSGPNSLRLEIRDLEE 483
               +L C         L++S   + L     D D     P    T    +L LE++ ++ 
Sbjct: 535  ERAVLTC---------LIISAVDYNLTWQRNDRDVRLAEPARIRTLA--NLSLELKSVKF 583

Query: 484  TDSGEYKCSATNSLGNATSTLDFHA-NAARLLISPAAE-VVEGQAVTLSCRSGLSPTPDA 541
             D+GEY C  ++  G++ +++        ++ + P  +    G  V++ C +   P P  
Sbjct: 584  NDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKP-- 641

Query: 542  RFSWYLNGALL------HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVL 595
            + +W +N   +            +L +  A+  DAG Y C A   +SA      + L  +
Sbjct: 642  KIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLA--SNSAGTDKQNSTLRYI 699

Query: 596  YPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCST 655
              P+     + L +       G   ++ C+    PP +++    D  +            
Sbjct: 700  EAPKLMVVQSELLV-----ALGDITVMECKTSGIPPPQVKWFKGDLELRP---------- 744

Query: 656  CGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFN-GQATVLAIA 714
                S  + +     LL+++    L  + G Y C A N  G A+   T + G   V    
Sbjct: 745  ----STFLIIDPLLGLLKIQETQDL--DAGDYTCVAINEAGRATGKITLDVGSPPVFIQE 798

Query: 715  PSHTLQE-GTEANLTCNVS---------REAAGSP--------ANFSWFRNGVLWAQGPL 756
            P+    E G+   L C V          R     P        ++ S  R G L+     
Sbjct: 799  PADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALF----- 853

Query: 757  ETVTLLPVARTDAALYACRILTEAG-AQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALF 815
                +L +  +D   Y C    + G  Q  T V ++ L  P      ++ ++ +G     
Sbjct: 854  ----ILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTL 909

Query: 816  ICT-VDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSY 874
             CT +   P+          +L  +    V S G            L +  + L D G Y
Sbjct: 910  PCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDG-----------SLHIERVQLQDGGEY 958

Query: 875  RCEATNVLGSSN--TSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYR 932
             C A+NV G++N  TS+   V              EG  V L C+  +G P+  S  W +
Sbjct: 959  TCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKA-SGNPK-PSVIWSK 1016

Query: 933  DGQPLQESTS-------ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPR 985
             G+ +  S++        +L   +    ++G Y C A       T+ A        YA R
Sbjct: 1017 KGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTA-------TNTA-------GYAKR 1062

Query: 986  HVTLTTLMDT---GPGRLGLLLCRVDSDPPAQLRLLHGDRL-VASTLQGVGGPEGSSPRL 1041
             V LT  +     G  R       +  D P ++ +L G+ + +   ++ +  P  +  + 
Sbjct: 1063 KVQLTVYVRPRVFGDQR------GLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKE 1116

Query: 1042 HVAVAPNTLR--------LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWP 1093
               ++P + R        ++I      D G+Y+C A+N  G  +      A  +NV V P
Sbjct: 1117 TQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVT-----QAVKLNVHVPP 1171

Query: 1094 -------GATVREGQLVNLTCLVWTTHPAQLTY-----TWYQDGQQRLD--AHSIPLPNV 1139
                      V+ GQ V++ C    T    +T+     T   DG+  +     ++ +   
Sbjct: 1172 KIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQA 1231

Query: 1140 TVRDATSYRC------GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLC 1193
            T  DA  Y C      G         +  P T++ L  P N   T   E    Q     C
Sbjct: 1232 TPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYN---TTFQERVANQRIEFPC 1288

Query: 1194 TVDSRPPAQLALSHAGRLLASST--AASVPNTLRLELRGPQPRDEGFYSCSARSPLGQAN 1251
                 P   +   H GR L       + + +   L +    P D G Y C A +  G   
Sbjct: 1289 PAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTE 1348

Query: 1252 TSLELRLEGVRVILAPE----AAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAA 1307
                L++    VI   E     +V       + C      +P +  WY +   + E    
Sbjct: 1349 RKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSP-IIMWYKDNVQVTESSTI 1407

Query: 1308 S-------LSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR 1360
                    L    AT   AG YSC+A +  GT S +   + VL  P   + ++F +  + 
Sbjct: 1408 QTVNNGKILKLFRATPEDAGRYSCKAINIAGT-SQKYFNIDVL-VPPTIIGTNFPNEVSV 1465

Query: 1361 SM---AVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVP 1417
             +     ++C V   P  ++    DGK          L  G  +V++      L +++  
Sbjct: 1466 VLNRDVALECQVKGTPFPDIHWFKDGK---------PLFLGDPNVELLDRGQVLHLKNAR 1516

Query: 1418 AGD-DTYVCTAQNLLGSISTIGRL------QVEGARVVAEPGLDVPEGAALNLSCRLLGG 1470
              D   Y CT  N  G  +   +L       ++G  V  +  + V   + + L C   G 
Sbjct: 1517 RNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTD--ISVLINSLIKLECETRGL 1574

Query: 1471 PGPVGNSTFAWFWNDRRL----HAEPVPTLAFTHVARAQ---AGMYHCLAELPTGAAASA 1523
            P P       W+ + + +     A  +    + H+ RAQ   +  Y C      G A   
Sbjct: 1575 PMP----AITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTA--- 1627

Query: 1524 PVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQP----- 1578
                      K+  + V+V P   + G L   ++ + + + +L L  +   +  P     
Sbjct: 1628 ---------EKSFHVDVYVPPM--IEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWL 1676

Query: 1579 -QGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620
              G P + + ++       +++I + +  D+G+YIC A++V G
Sbjct: 1677 KDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAG 1719



 Score =  109 bits (272), Expect = 3e-23
 Identities = 213/974 (21%), Positives = 351/974 (36%), Gaps = 134/974 (13%)

Query: 715  PSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGVLWA------QGPLETVTLLPVARTD 768
            P + LQ G    + C+V       P   S+ RNGV         +     + +  V  +D
Sbjct: 440  PGYYLQPG---QIPCSVDSLL---PFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSD 493

Query: 769  AALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLA 828
               Y C  ++ AG   +      V  PP   ++   + +  G  A+  C + S      A
Sbjct: 494  EGFYECIAVSSAGTGRAQ-TFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIIS------A 546

Query: 829  LFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTS 888
            + +           ++    R +  A   +L LE++ +   D+G Y C  ++  GSS  S
Sbjct: 547  VDYNLTWQRNDRDVRLAEPARIRTLA---NLSLELKSVKFNDAGEYHCMVSSEGGSSAAS 603

Query: 889  LFFQVRGAWVQVSPSPELQE---GQAVVLSCQVHTGVPEGTSYRWYRD-----GQPLQES 940
            +F  V+    +V+  P+ Q    G  V + C   TG P+        D         + +
Sbjct: 604  VFLTVQEP-PKVTVMPKNQSFTGGSEVSIMCSA-TGYPKPKIAWTVNDMFIVGSHRYRMT 661

Query: 941  TSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRL 1000
            +  TL         AG Y C A    SA T        ++  AP+ + + + +    G +
Sbjct: 662  SDGTLFIKNAAPKDAGIYGCLAS--NSAGTDKQNSTLRYIE-APKLMVVQSELLVALGDI 718

Query: 1001 GLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLE 1060
             ++ C+    PP Q++   GD  +              P   + + P    L+I      
Sbjct: 719  TVMECKTSGIPPPQVKWFKGDLELR-------------PSTFLIIDPLLGLLKIQETQDL 765

Query: 1061 DEGVYICEASNTLGQASASADFDAQA--VNVQVWPGATVREGQLVNLTCLVWTTHPAQLT 1118
            D G Y C A N  G+A+     D  +  V +Q     ++  G  V L C V   +P + T
Sbjct: 766  DAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYV-QGYP-EPT 823

Query: 1119 YTWYQ-------------DGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPIT 1165
              W +                 +L   ++ + N+   D  +Y C         +    +T
Sbjct: 824  IKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVT 883

Query: 1166 LDVLYAPR-NLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTL 1224
            +  L AP   +  +      G QL L    +   P  +        +L  +   +V +  
Sbjct: 884  VTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDG 943

Query: 1225 RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVP--EGAPITVTCA 1282
             L +   Q +D G Y+C A +  G  N +  + +  +  I   +  +   EG P+T+ C 
Sbjct: 944  SLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCK 1003

Query: 1283 DPAAHAPTLYTWYHNGRWLQEGPA-------ASLSFLVATRAHAGAYSCQAQDAQGTRSS 1335
                  P++  W   G  +    A        SL  +      +G Y C A +  G  + 
Sbjct: 1004 ASGNPKPSVI-WSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGY-AK 1061

Query: 1336 RPAALQVLYAPQDAVLSSFRDSRARSM-------------AVIQCTVDSEPPAELALSHD 1382
            R   L V   P+      F D R  S                + C V S PP  +  + +
Sbjct: 1062 RKVQLTVYVRPR-----VFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKE 1116

Query: 1383 GKVLATSSGVHS-LASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQ 1441
             ++++  S  H+ L SG+  +   R +              Y+C A N+ G+++   +L 
Sbjct: 1117 TQLISPFSPRHTFLPSGSMKITETRTS----------DSGMYLCVATNIAGNVTQAVKLN 1166

Query: 1442 VEGARVVAE--PGLDVPEGAALNLSCRLLGGPGPV-----GNSTFAWFWNDRRLH-AEPV 1493
            V     +      L V  G  +++ C   G P PV     G ST      D   H + P 
Sbjct: 1167 VHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLV---DGEHHVSNPD 1223

Query: 1494 PTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPP-----KTPTMMVFVEPEGGL 1548
             TL+      + AG+Y C+A    G   +  + L V  PP     + P    F E     
Sbjct: 1224 GTLSIDQATPSDAGIYTCVATNIAGTDETE-ITLHVQEPPTVEDLEPPYNTTFQERVANQ 1282

Query: 1549 RGILDCRVDSEPLASLT-LHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSD 1607
            R    C     P  ++  LH G  L           EP I +L     L   I ++ P D
Sbjct: 1283 RIEFPCPAKGTPKPTIKWLHNGRELTGR--------EPGISILEDGTLLV--IASVTPYD 1332

Query: 1608 QGEYICSASNVLGS 1621
             GEYIC A N  G+
Sbjct: 1333 NGEYICVAVNEAGT 1346



 Score =  103 bits (258), Expect = 1e-21
 Identities = 194/875 (22%), Positives = 315/875 (36%), Gaps = 132/875 (15%)

Query: 118  EISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTE---VDFNCSTPYVCLQEQV--- 171
            ++ +   ++ V   +   T    + T+  P  +  G +   +  N ST   C+ E V   
Sbjct: 3683 DLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTP 3742

Query: 172  RLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIH 231
            R+ W+      +           G  H+++ H+     D GR L C  + A    +  I 
Sbjct: 3743 RITWRKDGAVLAGNHARYSILENGFLHIQSAHVT----DTGRYL-CMATNAAGTDRRRID 3797

Query: 232  LQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQT------ 285
            LQV   P    I   P+   ++     TL C+         SI W K+G  L        
Sbjct: 3798 LQVHVPPS---IAPGPTNMTVIVNVQTTLACEATGI--PKPSINWRKNGHLLNVDQNQNS 3852

Query: 286  ----KTGVLHLPQAAWSDAGVYTCQAENGVGS---LVSPPISLHIFMAEVQVSPAGPILE 338
                 +G L +   +  D   Y C   NG G     V   + +   +A+    P   ++ 
Sbjct: 3853 YRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIAD---EPTDFLVT 3909

Query: 339  NQTVTLVCNTPNEAPSDLRYSWYKNHV-LLEDAHSHTLRLH-----LATRAD-TGFYFCE 391
                 ++  T +  P    + W KN + LL     + +        LAT+ +  G Y C 
Sbjct: 3910 KHAPAVITCTASGVPFPSIH-WTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCV 3968

Query: 392  VQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHI 451
             +N  GS     V++ V+ PP+     + L        +L C     P   +     G I
Sbjct: 3969 ARNAAGSAHRH-VTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEG-I 4026

Query: 452  LASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAA 511
              +TSG  +H+   SG        L+I      D+G Y C A N  G A   +  +    
Sbjct: 4027 NVNTSG-RNHAVLPSGG-------LQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVP 4078

Query: 512  RLLISPAAEVVEG--QAVTLSCRSGLSPTPDARFSWYLNGALLHEG------PGSSLLLP 563
             ++     E V    + +TLSC +   P PD   +W+ +G  + E          SL + 
Sbjct: 4079 PVISPHLKEYVIAVDKPITLSCEADGLPPPD--ITWHKDGRAIVESIRQRVLSSGSLQIA 4136

Query: 564  AASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLL 623
                 DAG Y C A   + A   S+   LTV  PPR  +      ++        + +L 
Sbjct: 4137 FVQPGDAGHYTCMA--ANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNE-----NSQAILP 4189

Query: 624  CRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEE 683
            C  D  P   +    KD V+  +L                K T  P    + + N +LE+
Sbjct: 4190 CVADGIPTPAINW-KKDNVLLANLLG--------------KYTAEP-YGELILENVVLED 4233

Query: 684  EGLYLCEASNALG--NASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSP-A 740
             G Y C A+NA G    + S T +   T   +    +L +G +  L+C    +A G P  
Sbjct: 4234 SGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSC----KATGIPLP 4289

Query: 741  NFSW-FRNGVLWA-----QGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLY 794
              +W F N ++ A      G  E V +  V++ D+  Y C      G   +   +     
Sbjct: 4290 KLTWTFNNNIIPAHFDSVNGHSELV-IERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEP 4348

Query: 795  PPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKA 854
            P  +    +      G  A+  C V   P   +                     ++  K 
Sbjct: 4349 PVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTI---------------------QWNRKG 4387

Query: 855  EANSLKLEVRELGLG----------DSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSP 904
                +   +R+LG G          D+G Y C ATN  G    S+   ++   +      
Sbjct: 4388 VDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPV 4447

Query: 905  E--LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL 937
            E  +  G  ++L+CQ  TG P+ T   W R G  +
Sbjct: 4448 ETVINAGGKIILNCQA-TGEPQPT-ITWSRQGHSI 4480



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 178/793 (22%), Positives = 286/793 (36%), Gaps = 127/793 (16%)

Query: 901  SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDG------QPLQESTSATLRFAAITLTQ 954
            +P   LQ GQ   + C V + +P   S+   R+G      Q L+ES S  L  A +TL+ 
Sbjct: 439  TPGYYLQPGQ---IPCSVDSLLPFTLSF--VRNGVTLGVDQYLKESASVNLDIAKVTLSD 493

Query: 955  AGAYHC---QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDP 1011
             G Y C    +   G A T         V   P +VT+T      PG   +L C + S  
Sbjct: 494  EGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVT------PGERAVLTCLIISAV 547

Query: 1012 PAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASN 1071
               L     DR V               R+        L LE+      D G Y C  S+
Sbjct: 548  DYNLTWQRNDRDVRL---------AEPARIRTLA---NLSLELKSVKFNDAGEYHCMVSS 595

Query: 1072 TLGQASASADFDAQ-AVNVQVWP-GATVREGQLVNLTC---------LVWTTHPAQLT-- 1118
              G ++AS     Q    V V P   +   G  V++ C         + WT +   +   
Sbjct: 596  EGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGS 655

Query: 1119 --YTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLR 1176
              Y    DG       ++ + N   +DA  Y C         + +   TL  + AP+ + 
Sbjct: 656  HRYRMTSDG-------TLFIKNAAPKDAGIYGCLASNSAGTDKQNS--TLRYIEAPKLMV 706

Query: 1177 LTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTL-RLELRGPQPRD 1235
            +   L    G + ++ C     PP Q+        L  ST   +   L  L+++  Q  D
Sbjct: 707  VQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLD 766

Query: 1236 EGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE--GAPITVTCADPAAHAPTLYT 1293
             G Y+C A +  G+A   + L +    V +   A V    G+ +T+ C       PT+  
Sbjct: 767  AGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTI-K 825

Query: 1294 WYHNGRWLQEGPAASLSFLVAT---------------RAHAGAYSCQAQDAQG-TRSSRP 1337
            W    R L   P  S  F V++                +  G Y C+A++  G  +S   
Sbjct: 826  W----RRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETT 881

Query: 1338 AALQVLYAPQDAVLSSFRDSRARSMAVIQCT-VDSEPPAELALSHDGKVLATSSGVHSLA 1396
              +  L AP   +  S  +        + CT +   P  E     +  +L  +  +   +
Sbjct: 882  VTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRS 941

Query: 1397 SGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV--AEPGLD 1454
             G+ H++      R+Q+QD       Y C A N+ G+ +    + V     +   +  L 
Sbjct: 942  DGSLHIE------RVQLQD----GGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILS 991

Query: 1455 VPEGAALNLSCRLLGGPGPVGNSTFAWFWNDR---------RLHAEPVPTLAFTHVARAQ 1505
              EG  + L C+  G P P      +  W+ +         +  A    +L        +
Sbjct: 992  TIEGIPVTLPCKASGNPKP------SVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEE 1045

Query: 1506 AGMYHCLAELPTGAAASAPVMLRVLYPPK--------TPTMMVFVEPEGGLRGILDCRVD 1557
            +G Y C A   T   A   V L V   P+        +    V +    G    L C V 
Sbjct: 1046 SGEYVCTA-TNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVK 1104

Query: 1558 SEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASN 1617
            S P   +T    ++L++   P+        H      +++  I   R SD G Y+C A+N
Sbjct: 1105 SLPPPIITWAKETQLISPFSPR--------HTFLPSGSMK--ITETRTSDSGMYLCVATN 1154

Query: 1618 VLGSASTSTYFGV 1630
            + G+ + +    V
Sbjct: 1155 IAGNVTQAVKLNV 1167



 Score = 71.6 bits (174), Expect = 6e-12
 Identities = 113/461 (24%), Positives = 163/461 (35%), Gaps = 44/461 (9%)

Query: 1193 CTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSP--LGQA 1250
            C+VDS  P  L+    G  L          ++ L++      DEGFY C A S    G+A
Sbjct: 451  CSVDSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRA 510

Query: 1251 NTSLELRLEGVRVILAP-EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAA-- 1307
             T  ++  E   VI  P    V  G    +TC   +A    L TW  N R ++    A  
Sbjct: 511  QTFFDVS-EPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNL-TWQRNDRDVRLAEPARI 568

Query: 1308 ------SLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARS 1361
                  SL         AG Y C    ++G  S+    L V   P+  V+   +     S
Sbjct: 569  RTLANLSLELKSVKFNDAGEYHCMV-SSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGS 627

Query: 1362 MAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD 1421
               I C+    P  ++A + +   +  S      + GT  ++ A           P    
Sbjct: 628  EVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNA----------APKDAG 677

Query: 1422 TYVCTAQNLLGSISTIGRLQ-VEGAR-VVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTF 1479
             Y C A N  G+      L+ +E  + +V +  L V  G    + C+  G P P      
Sbjct: 678  IYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPP----QV 733

Query: 1480 AWFWNDRRLHAEPV----PTLAFTHVARAQ---AGMYHCLAELPTGAAASAPVMLRVLYP 1532
             WF  D  L         P L    +   Q   AG Y C+A +     A+  + L V  P
Sbjct: 734  KWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVA-INEAGRATGKITLDVGSP 792

Query: 1533 PKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLAS 1592
            P        V  E G    L C V   P  ++       +   S+P    +   +   A 
Sbjct: 793  PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGA- 851

Query: 1593 PNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRAL 1633
                 + I  L  SD+G YIC A N  G   + T   V  L
Sbjct: 852  -----LFILNLWASDKGTYICEAENQFGKIQSETTVTVTGL 887



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 130/552 (23%), Positives = 212/552 (38%), Gaps = 85/552 (15%)

Query: 1133 SIPLPNVTVRDATSYRC------GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGG 1186
            ++ +  VT+ D   Y C      G G       +S P    V+  P N+ +T       G
Sbjct: 483  NLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPP--VIQVPNNVTVT------PG 534

Query: 1187 QLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPN--TLRLELRGPQPRDEGFYSCSAR 1244
            + A++ C + S     L      R +  +  A +     L LEL+  +  D G Y C   
Sbjct: 535  ERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVS 594

Query: 1245 SPLGQANTSLELRL-EGVRVILAPE-AAVPEGAPITVTCADPAAHAPTLYTWY------- 1295
            S  G +  S+ L + E  +V + P+  +   G+ +++ C+      P +  W        
Sbjct: 595  SEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKI-AWTVNDMFIV 653

Query: 1296 --HNGRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSS 1353
              H  R   +G   +L    A    AG Y C A ++ GT   + + L+ + AP+  V+ S
Sbjct: 654  GSHRYRMTSDG---TLFIKNAAPKDAGIYGCLASNSAGT-DKQNSTLRYIEAPKLMVVQS 709

Query: 1354 FRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQ- 1412
                    + V++C     PP ++        L  S+ +         +      L++Q 
Sbjct: 710  ELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLI--------IDPLLGLLKIQE 761

Query: 1413 VQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPE--GAALNLSCRLLGG 1470
             QD+ AGD  Y C A N  G  +    L V    V  +   DV    G+ + L C + G 
Sbjct: 762  TQDLDAGD--YTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGY 819

Query: 1471 PGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQA---------------GMYHCLAEL 1515
            P P    T  W    RRL   P+ +  F+  + +Q                G Y C AE 
Sbjct: 820  PEP----TIKW----RRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAEN 871

Query: 1516 PTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLA-SLTLHLGSRLVA 1574
              G   S            T T+   V P  G+   +   ++ + L    TL  G+ +  
Sbjct: 872  QFGKIQSET----------TVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPE 921

Query: 1575 SSQPQGAPA---EPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
                + +      P+I V +  +   + IE ++  D GEY C ASNV G+ + +T   V 
Sbjct: 922  RRWIKNSAMLLQNPYITVRSDGS---LHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVH 978

Query: 1632 ALHRLHQFQQLL 1643
             L  +   QQ+L
Sbjct: 979  VLPTIQHGQQIL 990



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 98/425 (23%), Positives = 165/425 (38%), Gaps = 63/425 (14%)

Query: 99   NLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDF 158
            +L +  +QP D+G Y     ++     S    T +TV   PR+ +      + E ++   
Sbjct: 4132 SLQIAFVQPGDAGHYTC---MAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAIL 4188

Query: 159  NCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQ 218
             C    +       + W+  +   +        EP G   LE + +    +D G    C 
Sbjct: 4189 PCVADGI---PTPAINWKKDNVLLANLLGKYTAEPYGELILENVVL----EDSG-FYTC- 4239

Query: 219  LSVANHRAQSEIH---LQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIK 275
              VAN+ A  + H   L V   P   ++   P   ++  GE + L+C+       +  + 
Sbjct: 4240 --VANNAAGEDTHTVSLTVHVLPTFTEL---PGDVSLNKGEQLRLSCKATGI--PLPKLT 4292

Query: 276  WLKDG----VRLQTKTG--VLHLPQAAWSDAGVYTCQAENGVGSLVS--------PPISL 321
            W  +         +  G   L + + +  D+G Y C AEN VG + +        PP+  
Sbjct: 4293 WTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPV-- 4350

Query: 322  HIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH------SHTL 375
              F  +   +   P+  N    L C    +    ++  W +  V +E +H      + +L
Sbjct: 4351 --FKGDYPSNWIEPLGGN--AILNCEVKGDPTPTIQ--WNRKGVDIEISHRIRQLGNGSL 4404

Query: 376  RLHLATRADTGFYFCEVQNVHGS-ERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCS 434
             ++     D G Y C   N  G  ERS  +S+ +  PP+  +        AG   IL+C 
Sbjct: 4405 AIYGTVNEDAGDYTCVATNEAGVVERS--MSLTLQSPPIITLEPVETVINAGGKIILNCQ 4462

Query: 435  VVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSAT 494
               EP  T+  S  GH   S S D D     S  S      L I D ++ D+ E++C A 
Sbjct: 4463 ATGEPQPTITWSRQGH---SISWD-DRVNVLSNNS------LYIADAQKEDTSEFECVAR 4512

Query: 495  NSLGN 499
            N +G+
Sbjct: 4513 NLMGS 4517


>gi|11225258 myelin associated glycoprotein isoform a precursor
           [Homo sapiens]
          Length = 626

 Score =  143 bits (361), Expect = 1e-33
 Identities = 111/422 (26%), Positives = 200/422 (47%), Gaps = 26/422 (6%)

Query: 4   LPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYD- 62
           LP   ++ S    G   WG   P  +   +G+C+ IPC F FP ++  P  +  +WY++ 
Sbjct: 7   LPLFWIMISASRGGH--WGAWMPSSISAFEGTCVSIPCRFDFPDELR-PAVVHGVWYFNS 63

Query: 63  -YSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISE 121
            Y      V   +  ++V   F+GR+  +G+   R C LLL ++ PE  G Y FR ++  
Sbjct: 64  PYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGG 123

Query: 122 VNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPA 181
            N+++  + +++ +      P I  P E++ GTEV+ +C  P  C + +  L W G +  
Sbjct: 124 YNQYTFSEHSVLDIV---NTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180

Query: 182 RSVTFNSQKFEPTGVG-HLETLHMAMSWQDHGRILRCQLSVANHRAQSE--IHLQVKYAP 238
                  +  E  G    +  LH   + + +G  L CQ S  N   Q E    + VKY P
Sbjct: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240

Query: 239 KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ---TKTGVLHLPQA 295
             V++    S    + G  V+L C  +S+ P +  + W++DG  L+    ++ +L L + 
Sbjct: 241 VIVEM---NSSVEAIEGSHVSLLCGADSNPPPL--LTWMRDGTVLREAVAESLLLELEEV 295

Query: 296 AWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPI--LENQTVTLVCNTPNEAP 353
             ++ GVY C AEN  G   +  + L +  A  + +  G +  +E +TV+++C+T +  P
Sbjct: 296 TPAEDGVYACLAENAYGQ-DNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSN-P 353

Query: 354 SDLRYSWYKNHVLLEDAHSHTLRLHL--ATRADTGFYFCEVQNVHGSERSGPVSVVVNHP 411
             +   + +  +L    +   L+L L   +  D G Y+C  +N +G +R+   ++ V   
Sbjct: 354 DPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYG-QRATAFNLSVEFA 412

Query: 412 PL 413
           P+
Sbjct: 413 PV 414



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 51/218 (23%), Positives = 89/218 (40%), Gaps = 18/218 (8%)

Query: 328 VQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHL--ATRADT 385
           V+++ +   +E   V+L+C   +  P  L  +W ++  +L +A + +L L L   T A+ 
Sbjct: 243 VEMNSSVEAIEGSHVSLLCGADSNPPPLL--TWMRDGTVLREAVAESLLLELEEVTPAED 300

Query: 386 GFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVL 445
           G Y C  +N +G +    V + V + P  P +   +    G    + CS  S P   L +
Sbjct: 301 GVYACLAENAYGQDNR-TVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTI 359

Query: 446 SHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD 505
                IL++   +S+             L+LE+  +   D GEY C A N  G   +  +
Sbjct: 360 FKEKQILSTVIYESE-------------LQLELPAVSPEDDGEYWCVAENQYGQRATAFN 406

Query: 506 FHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARF 543
                A +L+  +        V   C    +P P   F
Sbjct: 407 LSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 64/237 (27%), Positives = 99/237 (41%), Gaps = 34/237 (14%)

Query: 1056 GAMLEDEGVYI-------------------CEAS--NTLGQASASADFDAQAVNVQVWPG 1094
            G + EDEG ++                   C+AS  NT  Q    A  D +   V V   
Sbjct: 187  GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN 246

Query: 1095 ATVR--EGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS----IPLPNVTVRDATSYR 1148
            ++V   EG  V+L C   +  P  LT  W +DG    +A +    + L  VT  +   Y 
Sbjct: 247  SSVEAIEGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGVYA 304

Query: 1149 CGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHA 1208
            C         + +R + L V+YAP    +   + +  G+   +LC+  S P   L +   
Sbjct: 305  CLA--ENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKE 362

Query: 1209 GRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265
             ++L++    S    L+LEL    P D+G Y C A +  GQ  T+  L +E   V+L
Sbjct: 363  KQILSTVIYES---ELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 95/388 (24%), Positives = 150/388 (38%), Gaps = 59/388 (15%)

Query: 1298 GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRP-AALQVLYAPQDAVLSSFRD 1356
            G W+Q    + L F+    A+     CQA     T      A++ V Y P    ++S  +
Sbjct: 194  GTWVQ---VSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250

Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416
            +   S   + C  DS PP  L    DG VL                +    +L L++++V
Sbjct: 251  AIEGSHVSLLCGADSNPPPLLTWMRDGTVLR---------------EAVAESLLLELEEV 295

Query: 1417 -PAGDDTYVCTAQNLLGSISTIGRLQVEGA--RVVAEPGLDVPEGAALNLSCRLLGGPGP 1473
             PA D  Y C A+N  G  +    L V  A  +      +   EG  +++ C     P P
Sbjct: 296  TPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDP 355

Query: 1474 VGNSTFAWFWNDRRLHA----EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRV 1529
            +        + ++++ +    E    L    V+    G Y C+AE   G  A+A   L V
Sbjct: 356  I-----LTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATA-FNLSV 409

Query: 1530 LYPPKTPTMMVFVEPEGGLRGILDCR--VDSEPLASLTLHLGSR--LVASSQPQGAPAEP 1585
             + P    +++        R  + C   V S P  S+   L SR   V  S+ +   +E 
Sbjct: 410  EFAP----VLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSER 465

Query: 1586 HIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWV 1645
               VL S   LR   +A         IC+A N+ G+ S    F  +  HR      L+W 
Sbjct: 466  SGLVLTSILTLRGQAQA-----PPRVICTARNLYGAKSLELPF--QGAHR------LMWA 512

Query: 1646 ----LGLLVGLLLLLLGLGACYTWRRRR 1669
                +G +V   +L+  +  CY  + RR
Sbjct: 513  KIGPVGAVVAFAILIAIV--CYITQTRR 538



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 58/249 (23%), Positives = 98/249 (39%), Gaps = 22/249 (8%)

Query: 721 EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLL--PVARTDAALYACRILT 778
           EG+  +L C      +  P   +W R+G +  +   E++ L    V   +  +YAC +  
Sbjct: 253 EGSHVSLLCGAD---SNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYAC-LAE 308

Query: 779 EAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLAT 838
            A  Q +  V LSV+Y P +P ++  +   +G     +C+  S P  +L +F  + +L+T
Sbjct: 309 NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILST 368

Query: 839 SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV 898
            +                + L+LE+  +   D G Y C A N  G   T+    V  A V
Sbjct: 369 VI--------------YESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414

Query: 899 QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATL--RFAAITLTQAG 956
            +  S        V   C V +      ++        + ES    +    + + LT   
Sbjct: 415 LLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSIL 474

Query: 957 AYHCQAQAP 965
               QAQAP
Sbjct: 475 TLRGQAQAP 483



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 58/249 (23%), Positives = 95/249 (38%), Gaps = 37/249 (14%)

Query: 898  VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST--SATLRFAAITLTQA 955
            V+++ S E  EG  V L C   +  P   +  W RDG  L+E+   S  L    +T  + 
Sbjct: 243  VEMNSSVEAIEGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAED 300

Query: 956  GAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQL 1015
            G Y C A+   +A       + L V YAP   T+   M    G    +LC   S+P   L
Sbjct: 301  GVYACLAE---NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPIL 357

Query: 1016 RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQ 1075
             +    +++++ +                   + L+LE+     ED+G Y C A N  GQ
Sbjct: 358  TIFKEKQILSTVIY-----------------ESELQLELPAVSPEDDGEYWCVAENQYGQ 400

Query: 1076 ASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIP 1135
             + + +   +   V +           V   C+V             +   +   A  +P
Sbjct: 401  RATAFNLSVEFAPVLLLESHCAAARDTVQCLCVV-------------KSNPEPSVAFELP 447

Query: 1136 LPNVTVRDA 1144
              NVTV ++
Sbjct: 448  SRNVTVNES 456



 Score = 55.1 bits (131), Expect = 6e-07
 Identities = 52/228 (22%), Positives = 90/228 (39%), Gaps = 31/228 (13%)

Query: 515 ISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDA--GS 572
           ++ + E +EG  V+L C +  +P P    +W  +G +L E    SLLL     T A  G 
Sbjct: 245 MNSSVEAIEGSHVSLLCGADSNPPP--LLTWMRDGTVLREAVAESLLLELEEVTPAEDGV 302

Query: 573 YHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPA 632
           Y C A + +     +    L+V+Y P +PT    +      A  G    +LC   S+P  
Sbjct: 303 YACLAENAYGQD--NRTVGLSVMYAPWKPTVNGTM-----VAVEGETVSILCSTQSNPDP 355

Query: 633 RLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEAS 692
            L +  + ++++T +                      + L++E+     E++G Y C A 
Sbjct: 356 ILTIFKEKQILSTVI--------------------YESELQLELPAVSPEDDGEYWCVAE 395

Query: 693 NALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740
           N  G  +T+   + +   + +  SH           C V      S A
Sbjct: 396 NQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVA 443



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 95/398 (23%), Positives = 144/398 (36%), Gaps = 70/398 (17%)

Query: 904  PELQEGQAVVLSCQVHTGVPE-GTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYH--- 959
            PE+  G  V +SC V    PE      W       + +    LR    T  Q    H   
Sbjct: 147  PEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVP 206

Query: 960  ----------CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDS 1009
                      CQA  P + T       S+ V Y P  V + + ++   G    LLC  DS
Sbjct: 207  TREANGHRLGCQASFPNT-TLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADS 265

Query: 1010 DPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA 1069
            +PP  L  +                +G+  R  VA    +L LE+      ++GVY C A
Sbjct: 266  NPPPLLTWMR---------------DGTVLREAVA---ESLLLELEEVTPAEDGVYACLA 307

Query: 1070 SNTLGQASASADFDAQAVNVQVWPGATV--REGQLVNLTC--------LVWTTHPAQLTY 1119
             N  GQ + +          +     T+   EG+ V++ C        ++      Q+  
Sbjct: 308  ENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILS 367

Query: 1120 TWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY 1179
            T   + + +L+     LP V+  D   Y C      +  + +    L V +AP       
Sbjct: 368  TVIYESELQLE-----LPAVSPEDDGEYWCVA--ENQYGQRATAFNLSVEFAP-----VL 415

Query: 1180 LLESH---GGQLALVLCTVDSRPPAQLA---------LSHAGRLLASSTAASVPNTLRLE 1227
            LLESH          LC V S P   +A         ++ + R    S  + +  T  L 
Sbjct: 416  LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILT 475

Query: 1228 LRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265
            LRG Q +      C+AR+  G    SLEL  +G   ++
Sbjct: 476  LRG-QAQAPPRVICTARNLYGA--KSLELPFQGAHRLM 510



 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 44/182 (24%), Positives = 71/182 (39%), Gaps = 19/182 (10%)

Query: 402 GPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDH 461
           G  S+ V +PP+   + + +E   G    L C   S P   L     G +L     +   
Sbjct: 230 GYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAE--- 286

Query: 462 SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAA--RLLISPAA 519
                      SL LE+ ++   + G Y C A N+ G    T+      A  +  ++   
Sbjct: 287 -----------SLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTM 335

Query: 520 EVVEGQAVTLSCRSGLSPTPDARF--SWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRA 577
             VEG+ V++ C +  +P P         +   +++E     L LPA S  D G Y C A
Sbjct: 336 VAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE-LQLELPAVSPEDDGEYWCVA 394

Query: 578 RD 579
            +
Sbjct: 395 EN 396



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 63/282 (22%), Positives = 100/282 (35%), Gaps = 39/282 (13%)

Query: 722 GTEANLTCNV--------------SREAAGSPANFSWFRNGV-LWAQGPLETVTLLPVAR 766
           GTE  ++C V                E  G PA     R     W Q  L  +  +P   
Sbjct: 152 GTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSL--LHFVPTRE 209

Query: 767 TDAALYACRI-LTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLA 825
            +     C+        Q      + V YPP   ++++ ++  +G     +C  DS P  
Sbjct: 210 ANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPP 269

Query: 826 LLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSS 885
           LL                    G    +A A SL LE+ E+   + G Y C A N  G  
Sbjct: 270 LLTWMR---------------DGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD 314

Query: 886 NTSLFFQVRGA-W-VQVSPSPELQEGQAVVLSCQVHTGV-PEGTSYRWYRDGQPLQESTS 942
           N ++   V  A W   V+ +    EG+ V + C   +   P  T ++  +    +   + 
Sbjct: 315 NRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE 374

Query: 943 ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAP 984
             L   A++    G Y C A+   +     A   +L V +AP
Sbjct: 375 LQLELPAVSPEDDGEYWCVAE---NQYGQRATAFNLSVEFAP 413


>gi|18104957 myelin associated glycoprotein isoform b precursor
           [Homo sapiens]
          Length = 582

 Score =  143 bits (361), Expect = 1e-33
 Identities = 111/422 (26%), Positives = 200/422 (47%), Gaps = 26/422 (6%)

Query: 4   LPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYD- 62
           LP   ++ S    G   WG   P  +   +G+C+ IPC F FP ++  P  +  +WY++ 
Sbjct: 7   LPLFWIMISASRGGH--WGAWMPSSISAFEGTCVSIPCRFDFPDELR-PAVVHGVWYFNS 63

Query: 63  -YSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISE 121
            Y      V   +  ++V   F+GR+  +G+   R C LLL ++ PE  G Y FR ++  
Sbjct: 64  PYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGG 123

Query: 122 VNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPA 181
            N+++  + +++ +      P I  P E++ GTEV+ +C  P  C + +  L W G +  
Sbjct: 124 YNQYTFSEHSVLDIV---NTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180

Query: 182 RSVTFNSQKFEPTGVG-HLETLHMAMSWQDHGRILRCQLSVANHRAQSE--IHLQVKYAP 238
                  +  E  G    +  LH   + + +G  L CQ S  N   Q E    + VKY P
Sbjct: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240

Query: 239 KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ---TKTGVLHLPQA 295
             V++    S    + G  V+L C  +S+ P +  + W++DG  L+    ++ +L L + 
Sbjct: 241 VIVEM---NSSVEAIEGSHVSLLCGADSNPPPL--LTWMRDGTVLREAVAESLLLELEEV 295

Query: 296 AWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPI--LENQTVTLVCNTPNEAP 353
             ++ GVY C AEN  G   +  + L +  A  + +  G +  +E +TV+++C+T +  P
Sbjct: 296 TPAEDGVYACLAENAYGQ-DNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSN-P 353

Query: 354 SDLRYSWYKNHVLLEDAHSHTLRLHL--ATRADTGFYFCEVQNVHGSERSGPVSVVVNHP 411
             +   + +  +L    +   L+L L   +  D G Y+C  +N +G +R+   ++ V   
Sbjct: 354 DPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYG-QRATAFNLSVEFA 412

Query: 412 PL 413
           P+
Sbjct: 413 PV 414



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 51/218 (23%), Positives = 89/218 (40%), Gaps = 18/218 (8%)

Query: 328 VQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHL--ATRADT 385
           V+++ +   +E   V+L+C   +  P  L  +W ++  +L +A + +L L L   T A+ 
Sbjct: 243 VEMNSSVEAIEGSHVSLLCGADSNPPPLL--TWMRDGTVLREAVAESLLLELEEVTPAED 300

Query: 386 GFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVL 445
           G Y C  +N +G +    V + V + P  P +   +    G    + CS  S P   L +
Sbjct: 301 GVYACLAENAYGQDNR-TVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTI 359

Query: 446 SHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD 505
                IL++   +S+             L+LE+  +   D GEY C A N  G   +  +
Sbjct: 360 FKEKQILSTVIYESE-------------LQLELPAVSPEDDGEYWCVAENQYGQRATAFN 406

Query: 506 FHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARF 543
                A +L+  +        V   C    +P P   F
Sbjct: 407 LSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 64/237 (27%), Positives = 99/237 (41%), Gaps = 34/237 (14%)

Query: 1056 GAMLEDEGVYI-------------------CEAS--NTLGQASASADFDAQAVNVQVWPG 1094
            G + EDEG ++                   C+AS  NT  Q    A  D +   V V   
Sbjct: 187  GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN 246

Query: 1095 ATVR--EGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS----IPLPNVTVRDATSYR 1148
            ++V   EG  V+L C   +  P  LT  W +DG    +A +    + L  VT  +   Y 
Sbjct: 247  SSVEAIEGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGVYA 304

Query: 1149 CGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHA 1208
            C         + +R + L V+YAP    +   + +  G+   +LC+  S P   L +   
Sbjct: 305  CLA--ENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKE 362

Query: 1209 GRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265
             ++L++    S    L+LEL    P D+G Y C A +  GQ  T+  L +E   V+L
Sbjct: 363  KQILSTVIYES---ELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 95/388 (24%), Positives = 150/388 (38%), Gaps = 59/388 (15%)

Query: 1298 GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRP-AALQVLYAPQDAVLSSFRD 1356
            G W+Q    + L F+    A+     CQA     T      A++ V Y P    ++S  +
Sbjct: 194  GTWVQ---VSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250

Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416
            +   S   + C  DS PP  L    DG VL                +    +L L++++V
Sbjct: 251  AIEGSHVSLLCGADSNPPPLLTWMRDGTVLR---------------EAVAESLLLELEEV 295

Query: 1417 -PAGDDTYVCTAQNLLGSISTIGRLQVEGA--RVVAEPGLDVPEGAALNLSCRLLGGPGP 1473
             PA D  Y C A+N  G  +    L V  A  +      +   EG  +++ C     P P
Sbjct: 296  TPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDP 355

Query: 1474 VGNSTFAWFWNDRRLHA----EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRV 1529
            +        + ++++ +    E    L    V+    G Y C+AE   G  A+A   L V
Sbjct: 356  I-----LTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATA-FNLSV 409

Query: 1530 LYPPKTPTMMVFVEPEGGLRGILDCR--VDSEPLASLTLHLGSR--LVASSQPQGAPAEP 1585
             + P    +++        R  + C   V S P  S+   L SR   V  S+ +   +E 
Sbjct: 410  EFAP----VLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSER 465

Query: 1586 HIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWV 1645
               VL S   LR   +A         IC+A N+ G+ S    F  +  HR      L+W 
Sbjct: 466  SGLVLTSILTLRGQAQA-----PPRVICTARNLYGAKSLELPF--QGAHR------LMWA 512

Query: 1646 ----LGLLVGLLLLLLGLGACYTWRRRR 1669
                +G +V   +L+  +  CY  + RR
Sbjct: 513  KIGPVGAVVAFAILIAIV--CYITQTRR 538



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 58/249 (23%), Positives = 98/249 (39%), Gaps = 22/249 (8%)

Query: 721 EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLL--PVARTDAALYACRILT 778
           EG+  +L C      +  P   +W R+G +  +   E++ L    V   +  +YAC +  
Sbjct: 253 EGSHVSLLCGAD---SNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYAC-LAE 308

Query: 779 EAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLAT 838
            A  Q +  V LSV+Y P +P ++  +   +G     +C+  S P  +L +F  + +L+T
Sbjct: 309 NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILST 368

Query: 839 SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV 898
            +                + L+LE+  +   D G Y C A N  G   T+    V  A V
Sbjct: 369 VI--------------YESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414

Query: 899 QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATL--RFAAITLTQAG 956
            +  S        V   C V +      ++        + ES    +    + + LT   
Sbjct: 415 LLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSIL 474

Query: 957 AYHCQAQAP 965
               QAQAP
Sbjct: 475 TLRGQAQAP 483



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 58/249 (23%), Positives = 95/249 (38%), Gaps = 37/249 (14%)

Query: 898  VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST--SATLRFAAITLTQA 955
            V+++ S E  EG  V L C   +  P   +  W RDG  L+E+   S  L    +T  + 
Sbjct: 243  VEMNSSVEAIEGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAED 300

Query: 956  GAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQL 1015
            G Y C A+   +A       + L V YAP   T+   M    G    +LC   S+P   L
Sbjct: 301  GVYACLAE---NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPIL 357

Query: 1016 RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQ 1075
             +    +++++ +                   + L+LE+     ED+G Y C A N  GQ
Sbjct: 358  TIFKEKQILSTVIY-----------------ESELQLELPAVSPEDDGEYWCVAENQYGQ 400

Query: 1076 ASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIP 1135
             + + +   +   V +           V   C+V             +   +   A  +P
Sbjct: 401  RATAFNLSVEFAPVLLLESHCAAARDTVQCLCVV-------------KSNPEPSVAFELP 447

Query: 1136 LPNVTVRDA 1144
              NVTV ++
Sbjct: 448  SRNVTVNES 456



 Score = 55.1 bits (131), Expect = 6e-07
 Identities = 52/228 (22%), Positives = 90/228 (39%), Gaps = 31/228 (13%)

Query: 515 ISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDA--GS 572
           ++ + E +EG  V+L C +  +P P    +W  +G +L E    SLLL     T A  G 
Sbjct: 245 MNSSVEAIEGSHVSLLCGADSNPPP--LLTWMRDGTVLREAVAESLLLELEEVTPAEDGV 302

Query: 573 YHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPA 632
           Y C A + +     +    L+V+Y P +PT    +      A  G    +LC   S+P  
Sbjct: 303 YACLAENAYGQD--NRTVGLSVMYAPWKPTVNGTM-----VAVEGETVSILCSTQSNPDP 355

Query: 633 RLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEAS 692
            L +  + ++++T +                      + L++E+     E++G Y C A 
Sbjct: 356 ILTIFKEKQILSTVI--------------------YESELQLELPAVSPEDDGEYWCVAE 395

Query: 693 NALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740
           N  G  +T+   + +   + +  SH           C V      S A
Sbjct: 396 NQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVA 443



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 95/398 (23%), Positives = 144/398 (36%), Gaps = 70/398 (17%)

Query: 904  PELQEGQAVVLSCQVHTGVPE-GTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYH--- 959
            PE+  G  V +SC V    PE      W       + +    LR    T  Q    H   
Sbjct: 147  PEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVP 206

Query: 960  ----------CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDS 1009
                      CQA  P + T       S+ V Y P  V + + ++   G    LLC  DS
Sbjct: 207  TREANGHRLGCQASFPNT-TLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADS 265

Query: 1010 DPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA 1069
            +PP  L  +                +G+  R  VA    +L LE+      ++GVY C A
Sbjct: 266  NPPPLLTWMR---------------DGTVLREAVA---ESLLLELEEVTPAEDGVYACLA 307

Query: 1070 SNTLGQASASADFDAQAVNVQVWPGATV--REGQLVNLTC--------LVWTTHPAQLTY 1119
             N  GQ + +          +     T+   EG+ V++ C        ++      Q+  
Sbjct: 308  ENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILS 367

Query: 1120 TWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY 1179
            T   + + +L+     LP V+  D   Y C      +  + +    L V +AP       
Sbjct: 368  TVIYESELQLE-----LPAVSPEDDGEYWCVA--ENQYGQRATAFNLSVEFAP-----VL 415

Query: 1180 LLESH---GGQLALVLCTVDSRPPAQLA---------LSHAGRLLASSTAASVPNTLRLE 1227
            LLESH          LC V S P   +A         ++ + R    S  + +  T  L 
Sbjct: 416  LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILT 475

Query: 1228 LRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265
            LRG Q +      C+AR+  G    SLEL  +G   ++
Sbjct: 476  LRG-QAQAPPRVICTARNLYGA--KSLELPFQGAHRLM 510



 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 44/182 (24%), Positives = 71/182 (39%), Gaps = 19/182 (10%)

Query: 402 GPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDH 461
           G  S+ V +PP+   + + +E   G    L C   S P   L     G +L     +   
Sbjct: 230 GYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAE--- 286

Query: 462 SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAA--RLLISPAA 519
                      SL LE+ ++   + G Y C A N+ G    T+      A  +  ++   
Sbjct: 287 -----------SLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTM 335

Query: 520 EVVEGQAVTLSCRSGLSPTPDARF--SWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRA 577
             VEG+ V++ C +  +P P         +   +++E     L LPA S  D G Y C A
Sbjct: 336 VAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE-LQLELPAVSPEDDGEYWCVA 394

Query: 578 RD 579
            +
Sbjct: 395 EN 396



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 63/282 (22%), Positives = 100/282 (35%), Gaps = 39/282 (13%)

Query: 722 GTEANLTCNV--------------SREAAGSPANFSWFRNGV-LWAQGPLETVTLLPVAR 766
           GTE  ++C V                E  G PA     R     W Q  L  +  +P   
Sbjct: 152 GTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSL--LHFVPTRE 209

Query: 767 TDAALYACRI-LTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLA 825
            +     C+        Q      + V YPP   ++++ ++  +G     +C  DS P  
Sbjct: 210 ANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPP 269

Query: 826 LLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSS 885
           LL                    G    +A A SL LE+ E+   + G Y C A N  G  
Sbjct: 270 LLTWMR---------------DGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD 314

Query: 886 NTSLFFQVRGA-W-VQVSPSPELQEGQAVVLSCQVHTGV-PEGTSYRWYRDGQPLQESTS 942
           N ++   V  A W   V+ +    EG+ V + C   +   P  T ++  +    +   + 
Sbjct: 315 NRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE 374

Query: 943 ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAP 984
             L   A++    G Y C A+   +     A   +L V +AP
Sbjct: 375 LQLELPAVSPEDDGEYWCVAE---NQYGQRATAFNLSVEFAP 413


>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
          Length = 1215

 Score =  134 bits (338), Expect = 6e-31
 Identities = 180/727 (24%), Positives = 267/727 (36%), Gaps = 97/727 (13%)

Query: 855  EANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPE--LQEGQAV 912
            E+ +   E+      + G+Y C A +  G+        V     Q+ P+P   +  G+  
Sbjct: 358  ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETA 417

Query: 913  VLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITL-------TQAGAYHCQAQAP 965
            VLSC+V    P   +  W RD + L  ST    + A ++L       T  G Y C A   
Sbjct: 418  VLSCRVLGEAPYNLT--WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA 475

Query: 966  GSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVA 1025
               T    A + L V  AP+    T+      G    + C     P   +      + + 
Sbjct: 476  NGVT---RASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ 532

Query: 1026 STLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF--- 1082
                          R+HV        L I G   ED G Y C+A+N +G    +      
Sbjct: 533  -----------EDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 578

Query: 1083 ---DAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL------DAHS 1133
                  AVN  V     V  G+   L C      P ++   WY+ G + +       +  
Sbjct: 579  DPPSVSAVNAVV----LVAVGEEAVLVCEASGVPPPRV--IWYRGGLEMILAPEGSSSGK 632

Query: 1134 IPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVL 1192
            + +P    RDA +Y C  V   G A   S  I L V +AP+   L   +    G+ AL+ 
Sbjct: 633  LRIPAAQERDAGTYTCRAVNELGDA---SAEIQLAVGHAPQLTELPRDVTVELGRSALLA 689

Query: 1193 CTVDSRPPAQLALSHAG------RLLASSTAAS-VPNTLRLELRGPQPRDEGFYSCSARS 1245
            C    RPP  +            RL A   + S  P++  L      P D+  Y C AR+
Sbjct: 690  CRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 749

Query: 1246 PLGQANTSLELRLEGVR----VILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWL 1301
              G+      L + G         AP   V EG P+++ C   A        W  +GR L
Sbjct: 750  VFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPL 809

Query: 1302 QEGPA------ASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR 1355
              G         SL    A + HAG YSC A +  G++  R   L V   P+    ++  
Sbjct: 810  PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQ-HRDVELVVQVPPRIHPTATHH 868

Query: 1356 DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQD 1415
             +     A + C     P   +  + +   L TS G H   S  G + +A+ +     QD
Sbjct: 869  ITNEGVPASLPCVASGVPAPTITWTKETNAL-TSRGPHYNVSKEGTLLIAQPS----AQD 923

Query: 1416 VPAGDDTYVCTAQNLLG--------SISTIGRLQVEGARVVAEP-GLDVPEGAALNLSCR 1466
              A    YVCTA N +G        S++T  R+ + G+R    P  +    G  + L C 
Sbjct: 924  AGA----YVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCE 979

Query: 1467 LLGGPGPVGNSTFAWFWNDR-------RLHAEPVPTLAFTHVARAQAGMYHCLAELPTGA 1519
              G P P+      W  + R       R    P  +L    V    +G Y C A  P G+
Sbjct: 980  AKGSPPPL----VTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGS 1035

Query: 1520 AASAPVM 1526
            A+   V+
Sbjct: 1036 ASHRYVL 1042



 Score =  127 bits (319), Expect = 9e-29
 Identities = 173/702 (24%), Positives = 253/702 (36%), Gaps = 83/702 (11%)

Query: 683  EEGLYLCEASN--ALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740
            EEG Y C A +    G A            L  AP+ T+  G  A L+C V  EA   P 
Sbjct: 373  EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA---PY 429

Query: 741  NFSWFRNGVLWAQGPLETVTLLPVAR----------TDAALYACRILTEAGAQLSTPVLL 790
            N +W R+   W   P  T  +  +A           TD   Y C + + A       V L
Sbjct: 430  NLTWVRD---WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQC-VASNANGVTRASVWL 485

Query: 791  SVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRF 850
             V   P     ++     QG      C+    P          H+  +     +    R 
Sbjct: 486  LVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTP--------HISWSRESQALQEDSRI 537

Query: 851  QAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN--TSLFFQVRGAWVQVSPSPELQE 908
               A+     L ++ +   D+G+Y C+ATN +G+     +L++    +   V+    +  
Sbjct: 538  HVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAV 594

Query: 909  GQAVVLSCQVHTGVPEGTSYRWYRDGQPL----QESTSATLRFAAITLTQAGAYHCQAQA 964
            G+  VL C+  +GVP      WYR G  +    + S+S  LR  A     AG Y C+A  
Sbjct: 595  GEEAVLVCEA-SGVPPPRVI-WYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAV- 651

Query: 965  PGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLV 1024
              +     +A I L V +AP+   L   +    GR  LL CR    PP  +    GD   
Sbjct: 652  --NELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQP 709

Query: 1025 ASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF-- 1082
                 G G   GS  R      P++  L       ED+  Y+CEA N  G+  A A    
Sbjct: 710  LGLRLGAG--RGSRSR-----QPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762

Query: 1083 --DAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ---------RLDA 1131
               A        P   V EGQ V+L C+V    P    + W +DG+          R D 
Sbjct: 763  TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH-WLKDGRPLPPGSRHSIRADG 821

Query: 1132 HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPR-NLRLTYLLESHGGQLAL 1190
             S+ L       A  Y C       A    R + L V   PR +   T+ + + G   +L
Sbjct: 822  -SLHLDRALQEHAGRYSCVA--TNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASL 878

Query: 1191 VLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLG-- 1248
                     P          L +     +V     L +  P  +D G Y C+A + +G  
Sbjct: 879  PCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFS 938

Query: 1249 ------QANTSLELRLEGVRVILAP-EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWL 1301
                    NT   + + G R    P +     G  +T+ C +     P L TW  + R +
Sbjct: 939  SQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDC-EAKGSPPPLVTWTKDSRPV 997

Query: 1302 QE-------GPAASLSFLVATRAHAGAYSCQAQDAQGTRSSR 1336
                      P+ SL         +G Y C A +  G+ S R
Sbjct: 998  PPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHR 1039



 Score =  112 bits (279), Expect = 4e-24
 Identities = 164/667 (24%), Positives = 246/667 (36%), Gaps = 72/667 (10%)

Query: 1002 LLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061
            L+ C V S  P +L+L  G+  +                 H   + N+   EI  A   +
Sbjct: 328  LVSCSVHSALPFRLQLRRGEARLGE-------------ERHFQESGNS-SWEILRASKAE 373

Query: 1062 EGVYICEASNTLGQASASADFDAQAVNVQVWPG--ATVREGQLVNLTCLVWTTHPAQLTY 1119
            EG Y C A +  G   A A         Q+ P    TV  G+   L+C V    P  LT 
Sbjct: 374  EGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT- 432

Query: 1120 TWYQDGQ---------QRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLY 1170
             W +D +          +L   S+ +  +   D   Y+C         R S  + L V  
Sbjct: 433  -WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS--VWLLVRE 489

Query: 1171 APRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRG 1230
            AP+    T       G    V C+    P   ++ S   + L   +   V     L ++G
Sbjct: 490  APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQG 549

Query: 1231 PQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAA--VPEGAPITVTCADPAAHA 1288
              P D G YSC A + +G    ++ L       + A  A   V  G    + C + +   
Sbjct: 550  VAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC-EASGVP 608

Query: 1289 PTLYTWYHNGRWLQEGPAAS----LSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLY 1344
            P    WY  G  +   P  S    L    A    AG Y+C+A +  G  S+    L V +
Sbjct: 609  PPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE-IQLAVGH 667

Query: 1345 APQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSH-DGKVLATSSGVHSLASGTGHVQ 1403
            APQ   L           A++ C     PP  +     DG+ L        L +G G   
Sbjct: 668  APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL-----RLGAGRGSRS 722

Query: 1404 VARNALRLQVQDV-PAGDDTYVCTAQNLLGSISTIGRLQVEGAR----VVAEPGLDVPEG 1458
               ++  L  + V P     YVC A+N+ G +    RL V G        + P + V EG
Sbjct: 723  RQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEG 782

Query: 1459 AALNLSCRLLGG-PGPVGNSTFAWFWNDRRL---HAEPVPTLAFTHVARA---QAGMYHC 1511
              ++L C +L G P P  +    W  + R L       +      H+ RA    AG Y C
Sbjct: 783  QPVSLPCIVLAGRPLPERH----WLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSC 838

Query: 1512 LAELPTGAAASAPVMLRVLYPPKT-PTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGS 1570
            +A   T  +    V L V  PP+  PT    +  E G+   L C     P  ++T    +
Sbjct: 839  VA-TNTAGSQHRDVELVVQVPPRIHPTATHHITNE-GVPASLPCVASGVPAPTITWTKET 896

Query: 1571 RLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGV 1630
              + S  P    ++    ++A P+A           D G Y+C+A+N +G +S      V
Sbjct: 897  NALTSRGPHYNVSKEGTLLIAQPSA----------QDAGAYVCTATNTVGFSSQEMRLSV 946

Query: 1631 RALHRLH 1637
                R+H
Sbjct: 947  NTKPRIH 953



 Score =  107 bits (267), Expect = 1e-22
 Identities = 166/625 (26%), Positives = 229/625 (36%), Gaps = 105/625 (16%)

Query: 210  DHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYP 269
            D GR  +C  S AN   ++ + L V+ AP+   + +  S ++   G  V ++C   S YP
Sbjct: 464  DGGRY-QCVASNANGVTRASVWLLVREAPQ---VSIHTSSQHFSQGVEVKVSCSA-SGYP 518

Query: 270  AVSSIKWLKDGVRLQTKT-------GVLHLPQAAWSDAGVYTCQAENGVGS-------LV 315
                I W ++   LQ  +       G L +   A  DAG Y+CQA N VG+         
Sbjct: 519  T-PHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY 577

Query: 316  SPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLL----EDAH 371
            + P S+    A V V+        +   LVC      P   R  WY+  + +    E + 
Sbjct: 578  TDPPSVSAVNAVVLVAVG------EEAVLVCEASGVPPP--RVIWYRGGLEMILAPEGSS 629

Query: 372  SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGIL 431
            S  LR+  A   D G Y C   N  G + S  + + V H P    L   +  + G   +L
Sbjct: 630  SGKLRIPAAQERDAGTYTCRAVNELG-DASAEIQLAVGHAPQLTELPRDVTVELGRSALL 688

Query: 432  HCSVVSEPLATLVLSHG-GHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYK 490
             C     P  T+    G G  L    G    + R S +  P+S  L    +   D   Y 
Sbjct: 689  ACRATGRPPPTVTWRRGDGQPLGLRLG----AGRGSRSRQPDSGVLFFESVAPEDQAPYV 744

Query: 491  CSATNSLGN----ATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWY 546
            C A N  G     A   +  HA       +P   V+EGQ V+L C   L+  P     W 
Sbjct: 745  CEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIV-LAGRPLPERHWL 803

Query: 547  LNGALLHEGP------GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPR- 599
             +G  L  G         SL L  A    AG Y C A +  +A        L V  PPR 
Sbjct: 804  KDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATN--TAGSQHRDVELVVQVPPRI 861

Query: 600  QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGC 659
             PT T  +  +   A       L C V S  PA      K+    TS             
Sbjct: 862  HPTATHHITNEGVPAS------LPC-VASGVPAPTITWTKETNALTSR------------ 902

Query: 660  SPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG----------NASTSATFNGQAT 709
             P   V+K   LL   I  P  ++ G Y+C A+N +G          N       NG   
Sbjct: 903  GPHYNVSKEGTLL---IAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRN 959

Query: 710  VLAIAPSHTLQEGTEANLTCNVSREAAGSPANF-SWF-----------RNGVLWAQGPLE 757
               +    T + G E  L C    EA GSP    +W            R G+L    P  
Sbjct: 960  A-NVPLQVTAKAGEEVTLDC----EAKGSPPPLVTWTKDSRPVPPITNRYGLL----PSG 1010

Query: 758  TVTLLPVARTDAALYACRILTEAGA 782
            ++ L  V   D+  Y C     AG+
Sbjct: 1011 SLRLAQVQVGDSGHYECTASNPAGS 1035



 Score =  105 bits (263), Expect = 3e-22
 Identities = 182/747 (24%), Positives = 279/747 (37%), Gaps = 97/747 (12%)

Query: 761  LLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVD 820
            +L  ++ +   Y C  ++ AG   +   ++ V  PP +   +  + +  G  A+  C V 
Sbjct: 366  ILRASKAEEGTYECTAVSRAGTGRAKAQIV-VTDPPPQLVPAPNVTVSPGETAVLSCRVL 424

Query: 821  SRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATN 880
                  L       +L  S G            A+   L LE+  +   D G Y+C A+N
Sbjct: 425  GEAPYNLTWVRDWRVLPASTG----------RVAQLADLSLEISGIIPTDGGRYQCVASN 474

Query: 881  VLGSSNTSLFFQVRGAWVQVS---PSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL 937
              G +  S++  VR A  QVS    S    +G  V +SC   +G P      W R+ Q L
Sbjct: 475  ANGVTRASVWLLVREA-PQVSIHTSSQHFSQGVEVKVSCSA-SGYPT-PHISWSRESQAL 531

Query: 938  QEST------SATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTT 991
            QE +        TL    +    AG Y CQA    +   +    ++L+ +  P    +  
Sbjct: 532  QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQAT---NEVGTDQETVTLYYTDPPSVSAVNA 588

Query: 992  LMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLR 1051
            ++    G   +L+C     PP ++    G       L+ +  PEGSS            +
Sbjct: 589  VVLVAVGEEAVLVCEASGVPPPRVIWYRGG------LEMILAPEGSSSG----------K 632

Query: 1052 LEIHGAMLEDEGVYICEASNTLGQASASADFDA-QAVNVQVWP-GATVREGQLVNLTCLV 1109
            L I  A   D G Y C A N LG ASA        A  +   P   TV  G+   L C  
Sbjct: 633  LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRA 692

Query: 1110 WTTHPAQLTYTWYQ-DGQ--------------QRLDAHSIPLPNVTVRDATSYRCGVGPP 1154
                P   T TW + DGQ              ++ D+  +   +V   D   Y C     
Sbjct: 693  TGRPPP--TVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNV 750

Query: 1155 -GRAPRLSRPITLDVLYAPRNLRLTY----LLESHGGQLALVLCTVDSRPPAQLALSHAG 1209
             G+    +R I     +AP  +  +     +LE  G  ++L    +  RP  +      G
Sbjct: 751  FGKVQAEARLIVTG--HAPPQIASSAPTVRVLE--GQPVSLPCIVLAGRPLPERHWLKDG 806

Query: 1210 RLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEA 1269
            R L   +  S+     L L        G YSC A +  G  +  +EL ++ V   + P A
Sbjct: 807  RPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ-VPPRIHPTA 865

Query: 1270 A---VPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLS----FLVA--TRAHAG 1320
                  EG P ++ C      APT+            GP  ++S     L+A  +   AG
Sbjct: 866  THHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAG 925

Query: 1321 AYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR-------DSRARSMAVIQCTVDSEP 1373
            AY C A +  G  SS+   L V   P+  +  S          ++A     + C     P
Sbjct: 926  AYVCTATNTVGF-SSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSP 984

Query: 1374 PAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGS 1433
            P  +  + D + +   +  + L   +G +++A      QVQ   +G   Y CTA N  GS
Sbjct: 985  PPLVTWTKDSRPVPPITNRYGLLP-SGSLRLA------QVQVGDSGH--YECTASNPAGS 1035

Query: 1434 ISTIGRLQVEGARVVAEPGLDVPEGAA 1460
             S    L V+G        L VP   A
Sbjct: 1036 ASHRYVLGVQGRTSWQPQSLPVPHHPA 1062



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 173/738 (23%), Positives = 260/738 (35%), Gaps = 109/738 (14%)

Query: 380  ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEP 439
            A++A+ G Y C   +  G+ R+    +VV  PP   V    +    G   +L C V+ E 
Sbjct: 369  ASKAEEGTYECTAVSRAGTGRA-KAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA 427

Query: 440  LATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG- 498
               L       +L +++G           +    L LEI  +  TD G Y+C A+N+ G 
Sbjct: 428  PYNLTWVRDWRVLPASTG---------RVAQLADLSLEISGIIPTDGGRYQCVASNANGV 478

Query: 499  NATSTLDFHANAARLLISPAAE-VVEGQAVTLSCRSGLSPTPDARFSWYLNGALL----- 552
               S       A ++ I  +++   +G  V +SC +   PTP    SW      L     
Sbjct: 479  TRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTP--HISWSRESQALQEDSR 536

Query: 553  -HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDA 611
             H     +L++   +  DAG+Y C+A    +  G     V      P   +    + L A
Sbjct: 537  IHVDAQGTLIIQGVAPEDAGNYSCQAT---NEVGTDQETVTLYYTDPPSVSAVNAVVLVA 593

Query: 612  AGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNL 671
             G  A    +L+C     PP R+ + ++  +     P G         S ++++  A   
Sbjct: 594  VGEEA----VLVCEASGVPPPRV-IWYRGGLEMILAPEGSS-------SGKLRIPAAQE- 640

Query: 672  LRVEIHNPLLEEEGLYLCEASNALGNASTSATFN-GQATVLAIAPSH-TLQEGTEANLTC 729
                       + G Y C A N LG+AS       G A  L   P   T++ G  A L C
Sbjct: 641  ----------RDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLAC 690

Query: 730  NVSREAAGSPANFSWFR-------------NGVLWAQGPLETVTLLPVARTDAALYACRI 776
               R     P   +W R              G    Q     +    VA  D A Y C  
Sbjct: 691  ---RATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEA 747

Query: 777  LTEAG-AQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTV-DSRPLALLALFHGEH 834
                G  Q    ++++   PP     +  + + +G      C V   RPL         H
Sbjct: 748  RNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLP------ERH 801

Query: 835  LLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSS--NTSLFFQ 892
             L    G  +P   R   +A+ +   L +       +G Y C ATN  GS   +  L  Q
Sbjct: 802  WLKD--GRPLPPGSRHSIRADGS---LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ 856

Query: 893  VRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRD-------GQPLQESTSATL 945
            V       +      EG    L C V +GVP  T   W ++       G     S   TL
Sbjct: 857  VPPRIHPTATHHITNEGVPASLPC-VASGVPAPT-ITWTKETNALTSRGPHYNVSKEGTL 914

Query: 946  RFAAITLTQAGAYHCQA-QAPGSATTSLAAPIS----LHVSYAPRHVTLTTLMDTGPGRL 1000
              A  +   AGAY C A    G ++  +   ++    +H++   R+  +   +    G  
Sbjct: 915  LIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMN-GSRNANVPLQVTAKAGEE 973

Query: 1001 GLLLCRVDSDPPAQLRLLHGDRLVASTLQGVG-GPEGSSPRLHVAVAPNTLRLEIHGAML 1059
              L C     PP  +      R V       G  P GS              L +    +
Sbjct: 974  VTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGS--------------LRLAQVQV 1019

Query: 1060 EDEGVYICEASNTLGQAS 1077
             D G Y C ASN  G AS
Sbjct: 1020 GDSGHYECTASNPAGSAS 1037



 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 185/796 (23%), Positives = 281/796 (35%), Gaps = 150/796 (18%)

Query: 252  ILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTG--------VLHLPQAAWSDAGVY 303
            + PGE   L+C+V    P   ++ W++D   L   TG         L +     +D G Y
Sbjct: 411  VSPGETAVLSCRVLGEAPY--NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRY 468

Query: 304  TCQAENGVGSL---------VSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPS 354
             C A N  G            +P +S+H        + +    +   V + C+       
Sbjct: 469  QCVASNANGVTRASVWLLVREAPQVSIH--------TSSQHFSQGVEVKVSCSASGYPTP 520

Query: 355  DLRYSWYKNHVLLEDAHSH-----TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVN 409
             + +S  ++  L ED+  H     TL +      D G Y C+  N  G+++   V++   
Sbjct: 521  HISWS-RESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQE-TVTLYYT 578

Query: 410  HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGG--HILASTSGDSDHSPRFSG 467
             PP    + A +    G   +L C     P   ++   GG   ILA              
Sbjct: 579  DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP------------- 625

Query: 468  TSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFH-ANAARLLISPAAEVVE-GQ 525
              G +S +L I   +E D+G Y C A N LG+A++ +     +A +L   P    VE G+
Sbjct: 626  -EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGR 684

Query: 526  AVTLSCRSGLSPTPDA---RFSWYLNGALLHEGPGSS--------LLLPAASSTDAGSYH 574
            +  L+CR+   P P     R      G  L  G GS         L   + +  D   Y 
Sbjct: 685  SALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYV 744

Query: 575  CRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARL 634
            C AR+        +  ++T   PP+  +              G+   L C V +  P   
Sbjct: 745  CEARNVFGKVQAEARLIVTGHAPPQIAS-----SAPTVRVLEGQPVSLPCIVLAGRPLPE 799

Query: 635  QLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNA 694
            +   KD      LP G   S     S             + +   L E  G Y C A+N 
Sbjct: 800  RHWLKD---GRPLPPGSRHSIRADGS-------------LHLDRALQEHAGRYSCVATNT 843

Query: 695  LGNASTSATFNGQA--TVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFR-NGVL 750
             G+         Q    +   A  H   EG  A+L C     A+G PA   +W +    L
Sbjct: 844  AGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPC----VASGVPAPTITWTKETNAL 899

Query: 751  WAQGPLETV----TLL---PVARTDAALYACRILTEAGAQLSTPVLLSVLYPP------- 796
             ++GP   V    TLL   P A+ DA  Y C      G   S  + LSV   P       
Sbjct: 900  TSRGPHYNVSKEGTLLIAQPSAQ-DAGAYVCTATNTVGFS-SQEMRLSVNTKPRIHMNGS 957

Query: 797  DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEA 856
                +   +    G      C     P  L+              P  P   R+      
Sbjct: 958  RNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSR-------PVPPITNRYGLLPSG 1010

Query: 857  NSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRG--AWVQVSPSPELQEGQAVVL 914
            +   L + ++ +GDSG Y C A+N  GS++      V+G  +W            Q   L
Sbjct: 1011 S---LRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSW------------QPQSL 1055

Query: 915  SCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQ------AGAYHCQAQAPGSA 968
                H     G S        PL + T  ++R   ++L        A    C +QA  S+
Sbjct: 1056 PVPHHPACLSGLSV-------PLLQPTPRSVRLCHLSLRAPLPPPFATPTSCLSQACLSS 1108

Query: 969  TTSLAAPISLHVSYAP 984
            +T     +SLH+S  P
Sbjct: 1109 ST-----LSLHLSPYP 1119



 Score = 89.4 bits (220), Expect = 3e-17
 Identities = 171/772 (22%), Positives = 273/772 (35%), Gaps = 101/772 (13%)

Query: 910  QAVVLSCQVHTGVPEGTSYRWYR----DGQPLQESTSATLRFAAITLTQAGAYHCQAQAP 965
            Q +++SC VH+ +P     R       + +  QES +++      +  + G Y C A + 
Sbjct: 325  QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSR 384

Query: 966  GSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVA 1025
                 + A  +   V+  P  +     +   PG   +L CRV  + P  L  +   R++ 
Sbjct: 385  AGTGRAKAQIV---VTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL- 440

Query: 1026 STLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF--- 1082
                    P  +     +A     L LEI G +  D G Y C ASN  G   AS      
Sbjct: 441  --------PASTGRVAQLA----DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR 488

Query: 1083 DAQAVNVQVWPGATVREGQLVNLTC---------LVWTTHPAQLTYTWYQDGQQRLDAH- 1132
            +A  V++         +G  V ++C         + W+     L     +D +  +DA  
Sbjct: 489  EAPQVSIHT-SSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ----EDSRIHVDAQG 543

Query: 1133 SIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVL 1192
            ++ +  V   DA +Y C              +TL     P    +  ++    G+ A+++
Sbjct: 544  TLIIQGVAPEDAGNYSCQA--TNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 601

Query: 1193 CTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANT 1252
            C     PP ++     G  +  +   S    LR+     Q RD G Y+C A + LG A+ 
Sbjct: 602  CEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIP--AAQERDAGTYTCRAVNELGDASA 659

Query: 1253 SLELRLEGVRVI--LAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN------------- 1297
             ++L +     +  L  +  V  G    + C       PT+ TW                
Sbjct: 660  EIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTV-TWRRGDGQPLGLRLGAGR 718

Query: 1298 GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSS--FR 1355
            G   ++  +  L F          Y C+A++  G   +    +   +AP     S+   R
Sbjct: 719  GSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVR 778

Query: 1356 DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQD 1415
                + +++    +   P  E     DG+ L   S     A G+ H+  A     LQ   
Sbjct: 779  VLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRA-----LQEH- 832

Query: 1416 VPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLD--VPEGAALNLSCRLLGGPGP 1473
              AG   Y C A N  GS      L V+    +          EG   +L C   G P P
Sbjct: 833  --AG--RYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP 888

Query: 1474 VGNSTFAWFWNDRRL-------HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVM 1526
                T  W      L       +     TL     +   AG Y C A    G + S  + 
Sbjct: 889  ----TITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFS-SQEMR 943

Query: 1527 LRVLYPPK-------TPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQ 1579
            L V   P+          + + V  + G    LDC     P   +T    SR V      
Sbjct: 944  LSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPV------ 997

Query: 1580 GAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
              P   + + L    +LR  +  ++  D G Y C+ASN  GSAS     GV+
Sbjct: 998  --PPITNRYGLLPSGSLR--LAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045



 Score = 85.1 bits (209), Expect = 5e-16
 Identities = 128/523 (24%), Positives = 198/523 (37%), Gaps = 83/523 (15%)

Query: 100  LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159
            L+++ + PED+G+Y+ +   +EV   +D +   +  T+ P V  + + V +  G E    
Sbjct: 545  LIIQGVAPEDAGNYSCQ-ATNEVG--TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 601

Query: 160  CSTPYVCLQEQVRLQWQGQDPARSVTFNS---QKFEPTGVGHLETLHMAMSWQDHGRILR 216
            C                G  P R + +         P G    +    A   +D G    
Sbjct: 602  CEA-------------SGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYT- 647

Query: 217  CQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW 276
            C+       A +EI L V +AP+  ++   P    +  G    L C+     P   ++ W
Sbjct: 648  CRAVNELGDASAEIQLAVGHAPQLTEL---PRDVTVELGRSALLACRATGRPPP--TVTW 702

Query: 277  LKD-----GVRL---------QTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLH 322
             +      G+RL         Q  +GVL     A  D   Y C+A N  G + +    + 
Sbjct: 703  RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762

Query: 323  IFMAEVQVSPAGP---ILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLR--- 376
               A  Q++ + P   +LE Q V+L C      P   R+ W K+   L     H++R   
Sbjct: 763  TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH-WLKDGRPLPPGSRHSIRADG 821

Query: 377  -LHL--ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHC 433
             LHL  A +   G Y C   N  GS+      VV   P + P  T  + T  G+   L C
Sbjct: 822  SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHI-TNEGVPASLPC 880

Query: 434  SVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSA 493
                 P  T+  +   + L  TS    ++    GT       L I      D+G Y C+A
Sbjct: 881  VASGVPAPTITWTKETNAL--TSRGPHYNVSKEGT-------LLIAQPSAQDAGAYVCTA 931

Query: 494  TNSLGNATSTL--------DFHANAARLLISPAAEVVE-GQAVTLSCRSGLSPTPDARFS 544
            TN++G ++  +          H N +R    P     + G+ VTL C +  SP P    +
Sbjct: 932  TNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPP--LVT 989

Query: 545  WYLNG----------ALLHEGPGSSLLLPAASSTDAGSYHCRA 577
            W  +            LL   P  SL L      D+G Y C A
Sbjct: 990  WTKDSRPVPPITNRYGLL---PSGSLRLAQVQVGDSGHYECTA 1029



 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 78/315 (24%), Positives = 118/315 (37%), Gaps = 52/315 (16%)

Query: 217  CQLSVANHRAQSEIHLQVK-YAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIK 275
            C+      + Q+E  L V  +AP   +I  S     +L G+ V+L C V +  P +    
Sbjct: 745  CEARNVFGKVQAEARLIVTGHAPP--QIASSAPTVRVLEGQPVSLPCIVLAGRP-LPERH 801

Query: 276  WLKDGVRLQTKT-------GVLHLPQAAWSDAGVYTCQAENGVGS-------LVSPPISL 321
            WLKDG  L   +       G LHL +A    AG Y+C A N  GS       +V  P  +
Sbjct: 802  WLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI 861

Query: 322  HIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH-----TLR 376
            H        +   P       +L C         + ++   N +     H +     TL 
Sbjct: 862  HPTATHHITNEGVP------ASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLL 915

Query: 377  LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPV-------LTAFLETQAGLVG 429
            +   +  D G Y C   N  G   S  + + VN  P   +       +   +  +AG   
Sbjct: 916  IAQPSAQDAGAYVCTATNTVGFS-SQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEV 974

Query: 430  ILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSG---PNSLRLEIRDLEETDS 486
             L C     P            L + + DS   P  +   G     SLRL    ++  DS
Sbjct: 975  TLDCEAKGSPPP----------LVTWTKDSRPVPPITNRYGLLPSGSLRL--AQVQVGDS 1022

Query: 487  GEYKCSATNSLGNAT 501
            G Y+C+A+N  G+A+
Sbjct: 1023 GHYECTASNPAGSAS 1037



 Score = 40.4 bits (93), Expect = 0.015
 Identities = 87/393 (22%), Positives = 136/393 (34%), Gaps = 60/393 (15%)

Query: 40   PCIFSFPADVEVPDGITAIWYYDYSGQRQ--VVSHSADPKLVEARF-RGRTEFMGNPEHR 96
            P +   P DV V  G +A+     +G+    V     D + +  R   GR      P+  
Sbjct: 669  PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG 728

Query: 97   VCNLLLKDLQPEDSGSYNFRFEISEV-NRWSDVKGT---LVTVTEEPRVPTIASPVELLE 152
            V  L  + + PED   Y     + E  N +  V+     +VT    P++ + A  V +LE
Sbjct: 729  V--LFFESVAPEDQAPY-----VCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLE 781

Query: 153  GTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHL----ETLHMAMSW 208
            G  V   C            +   G+           +  P G  H      +LH+  + 
Sbjct: 782  GQPVSLPC------------IVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRAL 829

Query: 209  QDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSY 268
            Q+H     C  +        ++ L V+  P+     + P+  + +  E V  +    +S 
Sbjct: 830  QEHAGRYSCVATNTAGSQHRDVELVVQVPPR-----IHPTATHHITNEGVPASLPCVASG 884

Query: 269  PAVSSIKWLKDGVRLQT--------KTGVLHLPQAAWSDAGVYTCQAENGVG-------- 312
                +I W K+   L +        K G L + Q +  DAG Y C A N VG        
Sbjct: 885  VPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRL 944

Query: 313  SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLED--- 369
            S+ + P           V         + VTL C      P     +W K+   +     
Sbjct: 945  SVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPP--LVTWTKDSRPVPPITN 1002

Query: 370  ----AHSHTLRLHLATRADTGFYFCEVQNVHGS 398
                  S +LRL      D+G Y C   N  GS
Sbjct: 1003 RYGLLPSGSLRLAQVQVGDSGHYECTASNPAGS 1035


>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
            RhoGEF isoform a [Homo sapiens]
          Length = 6620

 Score =  119 bits (297), Expect = 3e-26
 Identities = 374/1644 (22%), Positives = 572/1644 (34%), Gaps = 315/1644 (19%)

Query: 100  LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159
            L++ D+ PED+G Y       E      V    V +T+  +       +E+LEG    F 
Sbjct: 2703 LVVHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKT------MEVLEGESCSFE 2756

Query: 160  CSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHM-AMSWQDHGRILRCQ 218
            C   +    +       G+        +S +F+ T  G    L +   +  D G ++   
Sbjct: 2757 CVLSHESASDPAMWTVGGK-----TVGSSSRFQATRQGRKYILVVREAAPSDAGEVV--- 2808

Query: 219  LSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLK 278
             SV      S+  L V+  P    I+     + + PGE V L C+++    A + + WLK
Sbjct: 2809 FSVRG--LTSKASLIVRERP--AAIIKPLEDQWVAPGEDVELRCELSR---AGTPVHWLK 2861

Query: 279  D--GVRLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHI----- 323
            D   +R   K  V        L +  A+  DAG YTC+ E    +      SLH+     
Sbjct: 2862 DRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKST-----ASLHVEEKAN 2916

Query: 324  ----FMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH------ 373
                 +  +QV   G      T    C T + A +    +W K  + L  +  H      
Sbjct: 2917 CFTEELTNLQVEEKG------TAVFTCKTEHPAAT---VTWRKGLLELRASGKHQPSQEG 2967

Query: 374  -TLRLHLAT--RADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGI 430
             TLRL ++   +AD+  Y C++    G  +S    +V             ++ Q G    
Sbjct: 2968 LTLRLTISALEKADSDTYTCDI----GQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSAT 3023

Query: 431  LHCSVVS---EPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
              C +     EP+   +     H  A+   + D  P      G + L L  R L   DSG
Sbjct: 3024 FRCRISPANYEPVHWFLDKTPLH--ANELNEIDAQP-----GGYHVLTL--RQLALKDSG 3074

Query: 488  EYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYL 547
                 A +   +A   +    +     ++ A  + EG+ +TL C +    T D    W  
Sbjct: 3075 TIYFEAGDQRASAALRVTEKPSVFSRELTDAT-ITEGEDLTLVCETS---TCDIPVCWTK 3130

Query: 548  NGALL---------HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
            +G  L         HEG  + LL+  A+  D+G Y C       A G  S +++ V    
Sbjct: 3131 DGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKC------EAGGACSSSIVRV--HA 3182

Query: 599  RQPTFTTRL-DLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCG 657
            R   F   L DL+    GA     L C V S   A ++  + + V+              
Sbjct: 3183 RPVRFQEALKDLEVLEGGA---ATLRC-VLSSVAAPVKWCYGNNVLRP------------ 3226

Query: 658  GCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNG---QATVLAIA 714
                +  + +   +L + + N   ++ G Y C    + G+ +TSAT       A  +   
Sbjct: 3227 --GDKYSLRQEGAMLELVVRNLRPQDSGRYSC----SFGDQTTSATLTVTALPAQFIGKL 3280

Query: 715  PSHTLQEGTEANLTCNVSREAAGSPANFS-WFRNG---VLWAQGPLETVTLLPVARTDAA 770
             +    EG  A L C +S+ A       S   R+G    L   G +  + +  +A  DAA
Sbjct: 3281 RNKEATEGATATLRCELSKAAPVEWRKGSETLRDGDRYCLRQDGAMCELQIRGLAMVDAA 3340

Query: 771  LYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALF 830
             Y+C      G + ++  L     P          +  +G  A   C +     A +   
Sbjct: 3341 EYSC----VCGEERTSASLTIRPMPAHFIGRLRHQESIEGATATLRCELSK--AAPVEWR 3394

Query: 831  HGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLF 890
             G   L            R   + +    +L++  L + D+G Y C    V G   TS  
Sbjct: 3395 KGRESLRDG--------DRHSLRQDGAVCELQICGLAVADAGEYSC----VCGEERTSAT 3442

Query: 891  FQVR---GAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRW------YRDGQPL---Q 938
              V+     + +   + E  EG   +L C++    P      W       RDG      Q
Sbjct: 3443 LTVKALPAKFTEGLRNEEAVEGATAMLWCELSKVAP----VEWRKGPENLRDGDRYILRQ 3498

Query: 939  ESTSATLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP 997
            E T   L+   + +  AG Y C   Q   SAT ++ A          R +      +   
Sbjct: 3499 EGTRCELQICGLAMADAGEYLCVCGQERTSATLTIRA-------LPARFIEDVKNQEARE 3551

Query: 998  GRLGLLLCRVDSDPPAQLR-----LLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRL 1052
            G   +L C ++S  P + R     L  GDR    +L+  G                   L
Sbjct: 3552 GATAVLQCELNSAAPVEWRKGSETLRDGDRY---SLRQDG---------------TKCEL 3593

Query: 1053 EIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG---ATVREGQLVNLTCLV 1109
            +I G  + D G Y C      GQ   SA    +A+ ++   G       EG    L C +
Sbjct: 3594 QIRGLAMADTGEYSC----VCGQERTSAMLTVRALPIKFTEGLRNEEATEGATAVLRCEL 3649

Query: 1110 WTTHPAQLTYTWYQDGQQRL---DAHS---------IPLPNVTVRDATSYRCGVGPPGRA 1157
                P +    W++ G + L   D HS         + +  +   DA  Y C  G    +
Sbjct: 3650 SKMAPVE----WWK-GHETLRDGDRHSLRQDGARCELQIRGLVAEDAGEYLCMCGKERTS 3704

Query: 1158 PRLS-RPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASST 1216
              L+ R +    +   RN       E+  G  A + C +    P +    H    L    
Sbjct: 3705 AMLTVRAMPSKFIEGLRN------EEATEGDTATLWCELSKAAPVEWRKGH--ETLRDGD 3756

Query: 1217 AASV---PNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEA---A 1270
              S+    +   L++RG    D G YSC      GQ  TS  L +  +      +     
Sbjct: 3757 RHSLRQDGSRCELQIRGLAVVDAGEYSCVC----GQERTSATLTVRALPARFIEDVKNQE 3812

Query: 1271 VPEGAPITVTC----ADPAAHAPTLYTWYHNGRW--LQEGPAASLSFLVATRAHAGAYSC 1324
              EGA   + C    A P        T     R+   Q+G    L     + A  G YSC
Sbjct: 3813 AREGATAVLQCELSKAAPVEWRKGSETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSC 3872

Query: 1325 QAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHD 1382
                       R +A   + APQ       +  +A   S A +QC + SEP A       
Sbjct: 3873 VC------GQERTSATLTVRAPQPVFREPLQSLQAEEGSTATLQCEL-SEPTA------- 3918

Query: 1383 GKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQ 1441
              V+ +  G+   A+G    ++      L +QD+   D   Y CT     GS +T   L 
Sbjct: 3919 -TVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTC----GSQATSATLT 3973

Query: 1442 VEGARVVAEPGL---DVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP------ 1492
            V  A V     L   +V EG   +L C L      V        W    L   P      
Sbjct: 3974 VTAAPVRFLRELQHQEVDEGGTAHLCCELSRAGASVE-------WRKGSLQLFPCAKYQM 4026

Query: 1493 -----VPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGG 1547
                    L    V +  AG Y C     TG   S   +   +  PK  T +  +E E G
Sbjct: 4027 VQDGAAAELLVRGVEQEDAGDYTC----DTGHTQSMASLSVRVPRPKFKTRLQSLEQETG 4082

Query: 1548 LRGILDCRV-DSEPLA-------SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVD 1599
                L C++ D+E  A        + LH G +    S  QGA  E  IH           
Sbjct: 4083 DIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRS--QGATRELLIH----------- 4129

Query: 1600 IEALRPSDQGEYICSASNVLGSAS 1623
               L   D GEY C       +AS
Sbjct: 4130 --QLEAKDTGEYACVTGGQKTAAS 4151



 Score =  108 bits (269), Expect = 6e-23
 Identities = 242/1165 (20%), Positives = 397/1165 (34%), Gaps = 237/1165 (20%)

Query: 255  GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYT 304
            G    L+C+V     A + + W KDG +L + + V          L LPQA  +DAG Y+
Sbjct: 1089 GASAMLSCEVAQ---AQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYS 1145

Query: 305  CQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTV---------TLVCNTPNEAPSD 355
            C+A           +S H+ + E    P G   + Q+V         T    +   A   
Sbjct: 1146 CEAG-------GQRVSFHLHITE----PKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQ 1194

Query: 356  LRYSWYKNHVLLEDAHSHTLRLHLATR---------ADTGFYFCEVQNVHGSER---SGP 403
               +WYK+   L  +    + +   TR         AD G Y CE      S +   + P
Sbjct: 1195 TEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEP 1254

Query: 404  VSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP 463
             +V         ++   + T+AG    L C V            G  + +S+        
Sbjct: 1255 KAVFAKE----QLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSS-------- 1302

Query: 464  RFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN--------AARLLI 515
            +    +     +L ++   + D+GEY C A          L FH +        A   L 
Sbjct: 1303 KVRIEAAGCMRQLVVQQAGQADAGEYTCEA------GGQRLSFHLDVSEPKAVFAKEQLA 1356

Query: 516  SPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHE---------GPGSSLLLPAAS 566
                +   G   TLSC    + T     +WY +G  L           G    L++  A 
Sbjct: 1357 HRKVQAEAGAIATLSCEVAQAQT---EVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQAC 1413

Query: 567  STDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRV 626
              D G Y C A  G   S     A   V++   QP            A AG    L C V
Sbjct: 1414 QADTGEYSCEA-GGQRLSFSLDVAEPKVVFAKEQPVHR------EVQAQAGASTTLSCEV 1466

Query: 627  DSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGL 686
                 A+ +++        S  S        GC+ R+ V +A   +            G 
Sbjct: 1467 ---AQAQTEVMWYKDGKKLSFSSKVRMEAV-GCTRRLVVQQAGQAV-----------AGE 1511

Query: 687  YLCEASNA-----LGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPAN 741
            Y CEA +      L  A   A F   A     +     + GT A L+C    E A +   
Sbjct: 1512 YSCEAGSQRLSFHLHVAEPKAVF---AKEQPASREVQAEAGTSATLSC----EVAQAQTE 1564

Query: 742  FSWFRNGV---------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQ-------LS 785
             +W+++G          + A G    + +    + DA  Y+C+    AG Q       ++
Sbjct: 1565 VTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCK----AGDQRLSFHLHVA 1620

Query: 786  TPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVP 845
             P ++     P   ++ A      G  A   C V      +     G+ L ++S      
Sbjct: 1621 EPKVVFAKEQPAHREVQA----EAGASATLSCEVAQAQTEVTWYKDGKKLSSSS------ 1670

Query: 846  SHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSP- 904
               + + +A   + +L V++ G  D+G Y CEA    G    S    V     Q+S  P 
Sbjct: 1671 ---KVRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQRLSFRLHVAELEPQISERPC 1723

Query: 905  -----ELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQES---------TSATLRFAAI 950
                  ++E + ++L+  + T  P   +  W +DG  ++ S          + TL     
Sbjct: 1724 RREPLVVKEHEDIILTATLAT--PSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGA 1781

Query: 951  TLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSD 1010
             +  +  Y C+  A G             V           L++   G LG  +      
Sbjct: 1782 QVLDSAIYSCRVGAEGQ---------DFPVQVEEVAAKFCRLLEPVCGELGGTVTLACEL 1832

Query: 1011 PPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLR-LEIHGAMLEDEGVYICEA 1069
             PA           A  +   G  +    +    VA   +R L + G   ED G Y+CE+
Sbjct: 1833 SPA----------CAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCES 1882

Query: 1070 SNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDG---- 1125
             +    A  +         +         EG      C+V    P+ +   W++DG    
Sbjct: 1883 RDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVV---SPSDVAVVWFRDGALLQ 1939

Query: 1126 -------QQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLT 1178
                    Q   +HS+ + ++ + DA            A   S    L V  AP   +  
Sbjct: 1940 PSEKFAISQSGASHSLTISDLVLEDAGQITV------EAEGASSSAALRVREAPVLFKKK 1993

Query: 1179 YLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPR---- 1234
               ++   + ++ L    +RP  +L      R   ++TA +    + +   G + R    
Sbjct: 1994 LEPQTVEERSSVTLEVELTRPWPEL------RWTRNATALAPGKNVEIHAEGARHRLVLH 2047

Query: 1235 -----DEGFYSCSARSPLGQANTSLELR----LEGVRVILAPEAAVPEGAPITVTCADPA 1285
                 D GF+ C       QA  ++E+R    + G++ + A E         T T     
Sbjct: 2048 NVGFADRGFFGCETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQG-------TATMEVQL 2100

Query: 1286 AHAPTLYTWYHNGRWLQEGPAASLS 1310
            +HA    +W  +G   Q+GP   L+
Sbjct: 2101 SHADVDGSWTRDGLRFQQGPTCHLA 2125



 Score =  107 bits (268), Expect = 8e-23
 Identities = 282/1306 (21%), Positives = 449/1306 (34%), Gaps = 223/1306 (17%)

Query: 441  ATLVLSHGGHILASTSGDSDHSP-----RFSGTSGPNSLRLEIRDLEETDSGEYKCSATN 495
            ATL     G+     S + D  P     RF      +  RL I DL   DSG+Y C A N
Sbjct: 27   ATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARN 86

Query: 496  SLGNATSTLDFHANAAR---------LLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWY 546
            ++G A + +    +A           LL   +  V EG   T  CR G SP P    SW 
Sbjct: 87   AIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRP--AVSWS 144

Query: 547  LNGALLHE-----------GPGSSLLLPAASSTDAGSYHCRAR--------------DGH 581
             +G  L E           G  S+L + AA   D G+Y  RA               D  
Sbjct: 145  KDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSD 204

Query: 582  SASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDR 641
            +A   S P   T             +  + A A     G   C V     ARL       
Sbjct: 205  AADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGE 264

Query: 642  VVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTS 701
                ++    G     G    +      N + ++I      + GLY C ASN +G   +S
Sbjct: 265  PKPETVWKKDGQLVTEGRRHVVYEDAQENFV-LKILFCKQSDRGLYTCTASNLVGQTYSS 323

Query: 702  ATFNGQATVLAI---APSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV-LWA----- 752
                 +   +          ++E   A   C V + +  +    +WF+    LWA     
Sbjct: 324  VLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPSTEA----AWFKEETRLWASAKYG 379

Query: 753  ---QGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQ 809
               +G    +T+  V+  D A+Y C   T  G++    + +        P+ +A   +  
Sbjct: 380  IEEEGTERRLTVRNVSADDDAVYICE--TPEGSRTVAELAVQGNLLRKLPRKTA---VRV 434

Query: 810  GHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869
            G  A+F C   + P+  +     +         +V + GR    AE     L + +  L 
Sbjct: 435  GDTAMF-CVELAVPVGPVHWLRNQE--------EVVAGGRVAISAEGTRHTLTISQCCLE 485

Query: 870  DSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGV------- 922
            D G    +   + G   TS  F      V     P LQ     V+  ++ + V       
Sbjct: 486  DVG----QVAFMAGDCQTSTQF-----CVSAPRKPPLQPPVDPVVKARMESSVILSWSPP 536

Query: 923  PEGT----------------SYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPG 966
            P G                 +Y W R     +    AT       + + G +  +  A  
Sbjct: 537  PHGERPVTIDGYLVEKKKLGTYTWIRCH---EAEWVATPELTVADVAEEGNFQFRVSALN 593

Query: 967  SATTS--LAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVD-SDPPAQLRLLHGDRL 1023
            S   S  L  P ++H+  AP+    T L        G +   VD +   A    L G  L
Sbjct: 594  SFGQSPYLEFPGTVHL--APKLAVRTPLKAVQAVEGGEVTFSVDLTVASAGEWFLDGQAL 651

Query: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFD 1083
             AS++      E    R    +    +   +HGA L+    ++     +  +    A   
Sbjct: 652  KASSVY-----EIHCDRTRHTLTIREVPASLHGAQLK----FVANGIESSIRMEVRA--- 699

Query: 1084 AQAVNVQVWPGATVRE--GQLVNLTCLVWTTHPAQLTYTWYQDG-----------QQRLD 1130
            A  +     P A  RE   +L     L+          TW +DG           Q    
Sbjct: 700  APGLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAG 759

Query: 1131 AHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVL--YAPRNLRLTYLLESHGGQL 1188
               + + +V   DA  Y C      R  R++  +++  L  +  +++  + +    GG  
Sbjct: 760  RRVLLVRDVARDDAGLYEC----VSRGGRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPA 815

Query: 1189 ALVLCTVDSRPPAQ-----LALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSA 1243
                 T ++          + L H+G          V    RL       +DEG YSC  
Sbjct: 816  QFECETSEAHVHVHWYKDGMELGHSGERFLQE---DVGTRHRLVAATVTRQDEGTYSCR- 871

Query: 1244 RSPLGQANTSLELRLEGVRVILAPE------AAVPEGAPITVTCADPAAHAPTLYTWYHN 1297
               +G+ +    LR+   +V+ A E           GA  T++C    A A T  TWY +
Sbjct: 872  ---VGEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSC--EVAQAQTEVTWYKD 926

Query: 1298 GRWLQEGPAASLSFLVATR---------AHAGAYSCQAQDAQGTRSSRPAALQVLYAPQD 1348
            G+ L       +     TR         A AG YSC+A   + +        +V++A +D
Sbjct: 927  GKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFA-KD 985

Query: 1349 AVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNA 1408
             V  S   + A + A + C V ++   E+    DGK L++S  VH  A G       R  
Sbjct: 986  QVAHSEVQAEAGASATLSCEV-AQAQTEVMWYKDGKKLSSSLKVHVEAKG-----CRRRL 1039

Query: 1409 LRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV------AEPGLDVPEGAALN 1462
            +  Q     AGD  Y C A+    S     RL +   +++          +    GA+  
Sbjct: 1040 VVQQAGKTDAGD--YSCEARGQRVSF----RLHITEPKMMFAKEQSVHNEVQAEAGASAM 1093

Query: 1463 LSCRLLGGPGPVGNSTFAWFWNDRRLHAEP---------VPTLAFTHVARAQAGMYHCLA 1513
            LSC +      V      W+ + ++L +              L      +A AG Y C A
Sbjct: 1094 LSCEVAQAQTEV-----TWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEA 1148

Query: 1514 ELPTGAAASAPVMLRVLYP----PKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLG 1569
                         L +  P     K  ++   V+ E G   +L C V ++P   +T +  
Sbjct: 1149 -----GGQRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEV-AQPQTEVTWYKD 1202

Query: 1570 SRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSA 1615
             + ++SS          + +       R+ ++ +  +D GEY C A
Sbjct: 1203 GKKLSSSS--------KVRMEVKGCTRRLVVQQVGKADAGEYSCEA 1240



 Score =  106 bits (264), Expect = 2e-22
 Identities = 312/1484 (21%), Positives = 520/1484 (35%), Gaps = 255/1484 (17%)

Query: 256  ELVTLTCQVNSSYPAVSSIKWLKDGVRL--QTKTGV--------LHLPQAAWSDAGVYTC 305
            E  T  C+V    P+  +  W K+  RL    K G+        L +   +  D  VY C
Sbjct: 348  ESATFLCEVPQ--PSTEAA-WFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYIC 404

Query: 306  QAENGVGSLVSPPISLHI-----------------FMAEVQVSPAGPI--LENQTVTLVC 346
            +   G  ++    +  ++                 F  E+ V P GP+  L NQ   +  
Sbjct: 405  ETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAV-PVGPVHWLRNQEEVVAG 463

Query: 347  NTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSV 406
                 +    R++   +   LED         +A    T   FC       + R  P+  
Sbjct: 464  GRVAISAEGTRHTLTISQCCLEDVGQVAF---MAGDCQTSTQFCV-----SAPRKPPLQ- 514

Query: 407  VVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466
                PP+ PV+ A +E+   L      S    P     ++  G+++      +    R  
Sbjct: 515  ----PPVDPVVKARMESSVIL------SWSPPPHGERPVTIDGYLVEKKKLGTYTWIRCH 564

Query: 467  GTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN---AARLLISP---AAE 520
                  +  L + D+ E  + +++ SA NS G +   L+F      A +L +     A +
Sbjct: 565  EAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPY-LEFPGTVHLAPKLAVRTPLKAVQ 623

Query: 521  VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDG 580
             VEG  VT S    +  T  +   W+L+G  L              ++     HC  R  
Sbjct: 624  AVEGGEVTFS----VDLTVASAGEWFLDGQAL-------------KASSVYEIHCD-RTR 665

Query: 581  HSASGPSSPAVL---TVLYPPRQPTFTTRLDLDAAG--------AGAGRRGLLLCRVDSD 629
            H+ +    PA L    + +       + R+++ AA         A A R   +L R+  +
Sbjct: 666  HTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAARE--VLARLHEE 723

Query: 630  PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLC 689
                 +L   D+  A +    G   + G   P+ +V  +     + + +   ++ GLY C
Sbjct: 724  AQLLAEL--SDQAAAVTWLKDGRTLSPG---PKYEVQASAGRRVLLVRDVARDDAGLYEC 778

Query: 690  EASNALGNASTSATFNGQATVLAIAPSHTLQE---GTEANLTCNVSREAAGSPANFSWFR 746
             +    G  +   +  G A  L    + +  +   G  A   C  S     +  +  W++
Sbjct: 779  VSRG--GRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPAQFECETSE----AHVHVHWYK 832

Query: 747  NGVLWAQ----------GPLETVTLLPVARTDAALYACRILTEA---GAQLSTPVLLSVL 793
            +G+              G    +    V R D   Y+CR+  ++     ++S P ++   
Sbjct: 833  DGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKVVFAK 892

Query: 794  YPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAK 853
                R KL A      G  A   C V      +     G+ L ++S         +   +
Sbjct: 893  EQLARRKLQA----EAGASATLSCEVAQAQTEVTWYKDGKKLSSSS---------KVCME 939

Query: 854  AEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV-----QVSPSP-ELQ 907
            A   + +L V++ G  D+G Y CEA    G    S    V+   V     QV+ S  + +
Sbjct: 940  ATGCTRRLVVQQAGQADAGEYSCEA----GGQRLSFHLDVKEPKVVFAKDQVAHSEVQAE 995

Query: 908  EGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSA---------TLRFAAITLTQAGAY 958
             G +  LSC+V       T   WY+DG+ L  S             L       T AG Y
Sbjct: 996  AGASATLSCEV---AQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDY 1052

Query: 959  HCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLL 1018
             C+A+       S    I+       +  ++   +    G   +L C V           
Sbjct: 1053 SCEAR---GQRVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQTEVTWYK 1109

Query: 1019 HGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA-----SNTL 1073
             G +L             SS ++ + V   T RL +  A   D G Y CEA     S  L
Sbjct: 1110 DGKKL------------SSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSFHL 1157

Query: 1074 GQASASADF-DAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH 1132
                    F   Q+V+ +V   A    G    L+C V      Q   TWY+DG++   + 
Sbjct: 1158 HITEPKGVFAKEQSVHNEVQAEA----GTTAMLSCEV---AQPQTEVTWYKDGKKLSSSS 1210

Query: 1133 SIPL-----------PNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLL 1181
             + +             V   DA  Y C  G  G+       IT       +   +   +
Sbjct: 1211 KVRMEVKGCTRRLVVQQVGKADAGEYSCEAG--GQRVSFQLHITEPKAVFAKEQLVHNEV 1268

Query: 1182 ESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT---LRLELRGPQPRDEGF 1238
             +  G  A + C V ++   ++     G+ L+SS+   +       +L ++     D G 
Sbjct: 1269 RTEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGE 1327

Query: 1239 YSCSARSPLGQANTSLELRLEGVRVILAPE------AAVPEGAPITVTCADPAAHAPTLY 1292
            Y+C A    G    S  L +   + + A E           GA  T++C    A A T  
Sbjct: 1328 YTCEA----GGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSC--EVAQAQTEV 1381

Query: 1293 TWYHNGRWLQEGPAASLSFLVATR---------AHAGAYSCQAQDAQGTRSSRPAALQVL 1343
            TWY +G+ L       +  +  TR         A  G YSC+A   + + S   A  +V+
Sbjct: 1382 TWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVV 1441

Query: 1344 YAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403
            +A +  V    + ++A +   + C V ++   E+    DGK L+ SS V   A G     
Sbjct: 1442 FAKEQPVHREVQ-AQAGASTTLSCEV-AQAQTEVMWYKDGKKLSFSSKVRMEAVG----- 1494

Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNL 1463
              R  +  Q     AG+ +    +Q L   +       V      A   +    G +  L
Sbjct: 1495 CTRRLVVQQAGQAVAGEYSCEAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATL 1554

Query: 1464 SCRLLGGPGPVGNSTFAWFWNDRRLHAEP---------VPTLAFTHVARAQAGMYHCLA- 1513
            SC +      V      W+ + ++L +              L      +A AG Y C A 
Sbjct: 1555 SCEVAQAQTEV-----TWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAG 1609

Query: 1514 --ELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSR 1571
               L      + P   +V++  + P     V+ E G    L C V            G +
Sbjct: 1610 DQRLSFHLHVAEP---KVVFAKEQPAHRE-VQAEAGASATLSCEVAQAQTEVTWYKDGKK 1665

Query: 1572 LVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSA 1615
            L +SS+         + V A     R+ ++    +D GEY C A
Sbjct: 1666 LSSSSK---------VRVEAVGCTRRLVVQQAGQADAGEYSCEA 1700



 Score =  104 bits (260), Expect = 6e-22
 Identities = 291/1322 (22%), Positives = 444/1322 (33%), Gaps = 219/1322 (16%)

Query: 94   EHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEG 153
            E  +  L+++    +D+G Y    E S+      V+      TEE            L  
Sbjct: 2877 EGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEE------------LTN 2924

Query: 154  TEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFN--------SQKFEPTGVGHLETLHMA 205
             +V+   +  + C  E          PA +VT+         S K +P+  G    L ++
Sbjct: 2925 LQVEEKGTAVFTCKTEH---------PAATVTWRKGLLELRASGKHQPSQEGLTLRLTIS 2975

Query: 206  MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVN 265
               +       C +  A  RAQ  +        + V I+      ++  G   T  C+++
Sbjct: 2976 ALEKADSDTYTCDIGQAQSRAQLLVQ------GRRVHIIEDLEDVDVQEGSSATFRCRIS 3029

Query: 266  SSYPAVSSIKWLKDGVRLQTKT-----------GVLHLPQAAWSDAG-VYTCQAENGVGS 313
             +      + W  D   L                VL L Q A  D+G +Y    +    +
Sbjct: 3030 PAN--YEPVHWFLDKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEAGDQRASA 3087

Query: 314  LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLE----- 368
             +       +F  E+  +    I E + +TLVC T   +  D+   W K+   L      
Sbjct: 3088 ALRVTEKPSVFSRELTDAT---ITEGEDLTLVCET---STCDIPVCWTKDGKTLRGSARC 3141

Query: 369  ----DAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQ 424
                + H   L +  AT  D+G Y CE     G   S  +  V   P         LE  
Sbjct: 3142 QLSHEGHRAQLLITGATLQDSGRYKCEA----GGACSSSIVRVHARPVRFQEALKDLEVL 3197

Query: 425  AGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEET 484
             G    L C V+S   A +   +G ++L    GD  +S R  G      L L +R+L   
Sbjct: 3198 EGGAATLRC-VLSSVAAPVKWCYGNNVLRP--GDK-YSLRQEGAM----LELVVRNLRPQ 3249

Query: 485  DSGEYKCSATNSLGNATSTLDFHANAARLLIS-PAAEVVEGQAVTLSCR-SGLSPTPDAR 542
            DSG Y CS  +   +AT T+   A  A+ +      E  EG   TL C  S  +P    +
Sbjct: 3250 DSGRYSCSFGDQTTSATLTVT--ALPAQFIGKLRNKEATEGATATLRCELSKAAPVEWRK 3307

Query: 543  FSWYLNG----ALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
             S  L       L  +G    L +   +  DA  Y C   +  ++      A LT+   P
Sbjct: 3308 GSETLRDGDRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTS------ASLTI--RP 3359

Query: 599  RQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGG 658
                F  RL    +  GA     L C +    P         R    SL  G        
Sbjct: 3360 MPAHFIGRLRHQESIEGA--TATLRCELSKAAPVEW------RKGRESLRDG-------- 3403

Query: 659  CSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAP--- 715
               R  + +   +  ++I    + + G Y C      G   TSAT   +A          
Sbjct: 3404 --DRHSLRQDGAVCELQICGLAVADAGEYSC----VCGEERTSATLTVKALPAKFTEGLR 3457

Query: 716  SHTLQEGTEANLTCNVSR----EAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAAL 771
            +    EG  A L C +S+    E    P N       +L  +G    + +  +A  DA  
Sbjct: 3458 NEEAVEGATAMLWCELSKVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGE 3517

Query: 772  YACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFH 831
            Y C    E  +   T   L   +  D     A     +G  A+  C ++S   A +    
Sbjct: 3518 YLCVCGQERTSATLTIRALPARFIEDVKNQEA----REGATAVLQCELNS--AAPVEWRK 3571

Query: 832  GEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFF 891
            G   L            R+  + +    +L++R L + D+G Y C    V G   TS   
Sbjct: 3572 GSETLRDG--------DRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAML 3619

Query: 892  QVRGAWVQVSP---SPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL---------QE 939
             VR   ++ +    + E  EG   VL C++    P      W++  + L         Q+
Sbjct: 3620 TVRALPIKFTEGLRNEEATEGATAVLRCELSKMAP----VEWWKGHETLRDGDRHSLRQD 3675

Query: 940  STSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGR 999
                 L+   +    AG Y C     G   TS    +    S   + +      +   G 
Sbjct: 3676 GARCELQIRGLVAEDAGEYLCMC---GKERTSAMLTVRAMPS---KFIEGLRNEEATEGD 3729

Query: 1000 LGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAML 1059
               L C +    P + R  H       TL+          R  +    +   L+I G  +
Sbjct: 3730 TATLWCELSKAAPVEWRKGH------ETLR-------DGDRHSLRQDGSRCELQIRGLAV 3776

Query: 1060 EDEGVYIC-----EASNTLGQASASADFDAQAVNVQVWPGAT-VREGQLVNLTCLVWTTH 1113
             D G Y C       S TL   +  A F     N +   GAT V + +L     + W   
Sbjct: 3777 VDAGEYSCVCGQERTSATLTVRALPARFIEDVKNQEAREGATAVLQCELSKAAPVEWRKG 3836

Query: 1114 PAQL----TYTWYQDGQQ-RLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV 1168
               L     Y+  QDG +  L  H +     +V D   Y C  G    +  L+      V
Sbjct: 3837 SETLRGGDRYSLRQDGTRCELQIHGL-----SVADTGEYSCVCGQERTSATLTVRAPQPV 3891

Query: 1169 LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPN----TL 1224
               P        L++  G  A + C + S P A +  S  G L   +     P     T 
Sbjct: 3892 FREP-----LQSLQAEEGSTATLQCEL-SEPTATVVWSKGG-LQLQANGRREPRLQGCTA 3944

Query: 1225 RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPE---AAVPEGAPITVTC 1281
             L L+  Q  D G Y+C+     G   TS  L +    V    E     V EG    + C
Sbjct: 3945 ELVLQDLQREDTGEYTCTC----GSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLCC 4000

Query: 1282 ADPAAHAPTLYTWYHNG---------RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGT 1332
                + A     W             + +Q+G AA L      +  AG Y+C     Q  
Sbjct: 4001 --ELSRAGASVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSM 4058

Query: 1333 RS 1334
             S
Sbjct: 4059 AS 4060



 Score =  103 bits (257), Expect = 1e-21
 Identities = 274/1256 (21%), Positives = 423/1256 (33%), Gaps = 235/1256 (18%)

Query: 274  IKWLKDGVRL--------QTKTGVLHLPQAAW---SDAGVYTCQA-ENGVGSLVSPPISL 321
            + W KDG+ L        Q   G  H   AA     D G Y+C+  E+ V   +      
Sbjct: 828  VHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPK 887

Query: 322  HIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH---------S 372
             +F  E             + TL C     A +    +WYK+   L  +          +
Sbjct: 888  VVFAKEQLARRKLQAEAGASATLSCEV---AQAQTEVTWYKDGKKLSSSSKVCMEATGCT 944

Query: 373  HTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLT----PVLTAFLETQAGLV 428
              L +  A +AD G Y CE     G +R     + V  P +      V  + ++ +AG  
Sbjct: 945  RRLVVQQAGQADAGEYSCEA----GGQRLS-FHLDVKEPKVVFAKDQVAHSEVQAEAGAS 999

Query: 429  GILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGE 488
              L C V       +    G  + +S     +        +     RL ++   +TD+G+
Sbjct: 1000 ATLSCEVAQAQTEVMWYKDGKKLSSSLKVHVE--------AKGCRRRLVVQQAGKTDAGD 1051

Query: 489  YKCSATNSLGNATSTLDFHANAARLLISPAAEVVE------GQAVTLSCRSGLSPTPDAR 542
            Y C A         +   H    +++ +    V        G +  LSC    + T    
Sbjct: 1052 YSCEARGQ----RVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQT---E 1104

Query: 543  FSWYLNGALLH---------EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLT 593
             +WY +G  L          +G    L+LP A   DAG Y C A       G    +   
Sbjct: 1105 VTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEA-------GGQRVSFHL 1157

Query: 594  VLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGC 653
             +  P+      +   +   A AG   +L C V    P      +KD    +S  S    
Sbjct: 1158 HITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQ--PQTEVTWYKDGKKLSS--SSKVR 1213

Query: 654  STCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAI 713
                GC+ R+ V +               + G Y CEA       S          V A 
Sbjct: 1214 MEVKGCTRRLVVQQVGKA-----------DAGEYSCEAGGQ--RVSFQLHITEPKAVFAK 1260

Query: 714  APSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLETVTLLPV 764
                  +  TEA  +  +S E A +    +W+++G          + A G +  + +   
Sbjct: 1261 EQLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQA 1320

Query: 765  ARTDAALYACRILTEAGAQ-------LSTPVLLSVLYPPDRPKLSALLDMGQGHMALFIC 817
             + DA  Y C    EAG Q       +S P  +         K+ A      G +A   C
Sbjct: 1321 GQADAGEYTC----EAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQA----EAGAIATLSC 1372

Query: 818  TVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCE 877
             V      +     G+ L ++S         + + +A   + +L V++    D+G Y CE
Sbjct: 1373 EVAQAQTEVTWYKDGKKLSSSS---------KVRMEAVGCTRRLVVQQACQADTGEYSCE 1423

Query: 878  ATNVLGSSNTSLFFQVRGAWV------QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWY 931
            A    G    S    V    V       V    + Q G +  LSC+V       T   WY
Sbjct: 1424 A----GGQRLSFSLDVAEPKVVFAKEQPVHREVQAQAGASTTLSCEV---AQAQTEVMWY 1476

Query: 932  RDGQPLQESTSATLRFAAITLTQ-----------AGAYHCQAQAPGSATTSLAAPISLHV 980
            +DG+ L  S S+ +R  A+  T+           AG Y C+A   GS   S    ++   
Sbjct: 1477 KDGKKL--SFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCEA---GSQRLSFHLHVAEPK 1531

Query: 981  SYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPR 1040
            +   +    +  +    G    L C V            G +L             SS +
Sbjct: 1532 AVFAKEQPASREVQAEAGTSATLSCEVAQAQTEVTWYKDGKKL------------SSSSK 1579

Query: 1041 LHVAVAPNTLRLEIHGAMLEDEGVYICEASNT-----LGQASASADFDAQAV---NVQVW 1092
            + +     T RL +  A   D G Y C+A +      L  A     F  +      VQ  
Sbjct: 1580 VRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAE 1639

Query: 1093 PGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVR---------- 1142
             GA+        L+C V     AQ   TWY+DG++   +  + +  V             
Sbjct: 1640 AGASA------TLSCEV---AQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQ 1690

Query: 1143 -DATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALV--LCTVDSRP 1199
             DA  Y C  G    + RL     L+   + R  R   L+      + L   L T  +  
Sbjct: 1691 ADAGEYSCEAGGQRLSFRL-HVAELEPQISERPCRREPLVVKEHEDIILTATLATPSAAT 1749

Query: 1200 PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE 1259
               L      R       AS  +T  L + G Q  D   YSC     +G       +++E
Sbjct: 1750 VTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCR----VGAEGQDFPVQVE 1805

Query: 1260 GVRV----ILAPEAAVPEGAPITVTCADPAAHAPTLY----TWYHNGRWLQ---EGPAAS 1308
             V      +L P      G  +T+ C    A A  ++    T    G+  Q   EGP  S
Sbjct: 1806 EVAAKFCRLLEPVCG-ELGGTVTLACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRS 1864

Query: 1309 LSFLVATRAHAGAYSCQAQD----AQGTRS------------------SRPAALQVLYAP 1346
            L+ L      AG Y C+++D    AQ T S                     A  Q + +P
Sbjct: 1865 LTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVVSP 1924

Query: 1347 QDAVLSSFRDSR----ARSMAVIQCTVD-SEPPAELALSHDGKVLATSSGVHSLAS 1397
             D  +  FRD      +   A+ Q     S   ++L L   G++   + G  S A+
Sbjct: 1925 SDVAVVWFRDGALLQPSEKFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAA 1980



 Score =  102 bits (255), Expect = 2e-21
 Identities = 283/1294 (21%), Positives = 450/1294 (34%), Gaps = 235/1294 (18%)

Query: 59   WYYDYSGQRQVVSHSADPKLVEARFRG--------RTEFMGNPEHRVCNLLLKDLQPEDS 110
            W     G+R V   + D  LVE +  G          E++  PE     L + D+  E  
Sbjct: 533  WSPPPHGERPV---TIDGYLVEKKKLGTYTWIRCHEAEWVATPE-----LTVADVAEEG- 583

Query: 111  GSYNFRFEISEVNRWS-----DVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYV 165
               NF+F +S +N +      +  GT V +  +  V T    V+ +EG EV F+      
Sbjct: 584  ---NFQFRVSALNSFGQSPYLEFPGT-VHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVA 639

Query: 166  CLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLE---TLHMAMSWQDHGRILRCQLSVA 222
               E     W           + Q  + + V  +    T H     +    +   QL   
Sbjct: 640  SAGE-----W---------FLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFV 685

Query: 223  NHRAQSEIHLQVKYAPKGVKILLSPSG--RNILPG--ELVTLTCQVNSSYPAVSSIKWLK 278
             +  +S I ++V+ AP G+     P+   R +L    E   L  +++    AV+   WLK
Sbjct: 686  ANGIESSIRMEVRAAP-GLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVT---WLK 741

Query: 279  DGVRL--------QTKTG--VLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEV 328
            DG  L        Q   G  VL +   A  DAG+Y C +  G  +       L  F+ + 
Sbjct: 742  DGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKD 801

Query: 329  QVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHV---------LLEDAHS-HTLRLH 378
                    +        C T   + + +   WYK+ +         L ED  + H L   
Sbjct: 802  MAGSCVDAVAGGPAQFECET---SEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAA 858

Query: 379  LATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLT----PVLTAFLETQAGLVGILHCS 434
              TR D G Y C V      E S    + V+ P +      +    L+ +AG    L C 
Sbjct: 859  TVTRQDEGTYSCRV-----GEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSCE 913

Query: 435  VVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSAT 494
            V            G  + +S+        +    +   + RL ++   + D+GEY C A 
Sbjct: 914  VAQAQTEVTWYKDGKKLSSSS--------KVCMEATGCTRRLVVQQAGQADAGEYSCEAG 965

Query: 495  NSLGNATSTLDFHANAARLLISPAAEVVE--------GQAVTLSCRSGLSPTPDARFSWY 546
                     L FH +     +  A + V         G + TLSC    + T      WY
Sbjct: 966  GQ------RLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSCEVAQAQT---EVMWY 1016

Query: 547  LNGALLH---------EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYP 597
             +G  L          +G    L++  A  TDAG Y C AR G   S         +++ 
Sbjct: 1017 KDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEAR-GQRVSFRLHITEPKMMFA 1075

Query: 598  PRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLL-HKDRVVATSLPSGGGCSTC 656
              Q         +   A AG   +L C V     A+ ++  +KD    +S    G     
Sbjct: 1076 KEQSVH------NEVQAEAGASAMLSCEV---AQAQTEVTWYKDGKKLSSSSKVG--MEV 1124

Query: 657  GGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPS 716
             GC+ R+ + +A              + G Y CEA       S          V A   S
Sbjct: 1125 KGCTRRLVLPQAGK-----------ADAGEYSCEAGGQ--RVSFHLHITEPKGVFAKEQS 1171

Query: 717  HTLQEGTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLETVTLLPVART 767
               +   EA  T  +S E A      +W+++G          +  +G    + +  V + 
Sbjct: 1172 VHNEVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKA 1231

Query: 768  DAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLD----MGQGHMALFICTVDSRP 823
            DA  Y+C    EAG Q      L +  P        L+        G  A   C V    
Sbjct: 1232 DAGEYSC----EAGGQ-RVSFQLHITEPKAVFAKEQLVHNEVRTEAGASATLSCEVAQAQ 1286

Query: 824  LALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLG 883
              +     G+ L ++S         + + +A     +L V++ G  D+G Y CEA    G
Sbjct: 1287 TEVTWYKDGKKLSSSS---------KVRIEAAGCMRQLVVQQAGQADAGEYTCEA----G 1333

Query: 884  SSNTSLFFQVRGAWVQVSPSP------ELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL 937
                S    V       +         + + G    LSC+V     E T   WY+DG+ L
Sbjct: 1334 GQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQTEVT---WYKDGKKL 1390

Query: 938  QESTSATLRFAAITLTQ-----------AGAYHCQAQAPG-SATTSLAAPISLHVSYAPR 985
              S+S+ +R  A+  T+            G Y C+A     S +  +A P  +     P 
Sbjct: 1391 --SSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVFAKEQPV 1448

Query: 986  HVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAV 1045
            H      +    G    L C V       +    G +L              S ++ +  
Sbjct: 1449 H----REVQAQAGASTTLSCEVAQAQTEVMWYKDGKKL------------SFSSKVRMEA 1492

Query: 1046 APNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNL 1105
               T RL +  A     G Y CEA +           + +AV  +  P +   + +    
Sbjct: 1493 VGCTRRLVVQQAGQAVAGEYSCEAGSQRLSFHLHV-AEPKAVFAKEQPASREVQAEAGTS 1551

Query: 1106 TCLVWTTHPAQLTYTWYQDGQQ-------RLDA----HSIPLPNVTVRDATSYRCGVGPP 1154
              L      AQ   TWY+DG++       R++A      + +      DA  Y C  G  
Sbjct: 1552 ATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQ 1611

Query: 1155 GRAPRL--SRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLL 1212
              +  L  + P  +     P +      +++  G  A + C V ++   ++     G+ L
Sbjct: 1612 RLSFHLHVAEPKVVFAKEQPAHRE----VQAEAGASATLSCEV-AQAQTEVTWYKDGKKL 1666

Query: 1213 ASST---AASVPNTLRLELRGPQPRDEGFYSCSA 1243
            +SS+     +V  T RL ++     D G YSC A
Sbjct: 1667 SSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA 1700



 Score = 94.7 bits (234), Expect = 7e-19
 Identities = 329/1543 (21%), Positives = 511/1543 (33%), Gaps = 276/1543 (17%)

Query: 229  EIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSS-YPAVSSIKWLKDGVRLQTKT 287
            ++  +   A +    LL P+   +  G   T  C+V  S  PAVS   W KDG RL    
Sbjct: 98   QVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVS---WSKDGRRLGEPD 154

Query: 288  G------------VLHLPQAAWSDAGVYTCQAENGVGSLVS----------------PPI 319
            G             L +  A   D G Y  +AEN +G+  +                P  
Sbjct: 155  GPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGT 214

Query: 320  SLHIFMAEVQV---------SPAGP---------ILENQTVTLVCNTPNEAPSDLRYSWY 361
            S    +A +Q          +PA P         + E +   L C    E   +    W 
Sbjct: 215  STAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPET--VWK 272

Query: 362  KN---------HVLLEDAHSH-TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHP 411
            K+         HV+ EDA  +  L++    ++D G Y C   N+ G   S  + VV    
Sbjct: 273  KDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVV--RE 330

Query: 412  PLTPVLTAF--LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTS 469
            P  P       LE +        C V               + AS     +      GT 
Sbjct: 331  PAVPFKKRLQDLEVREKESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEE----GTE 386

Query: 470  GPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTL 529
                 RL +R++   D   Y C          + L    N  R L  P    V      +
Sbjct: 387  R----RLTVRNVSADDDAVYICETPEG-SRTVAELAVQGNLLRKL--PRKTAVRVGDTAM 439

Query: 530  SCRSGLSPTPDARFSWYLNG---------ALLHEGPGSSLLLPAASSTDAGSY-----HC 575
             C     P       W  N          A+  EG   +L +      D G        C
Sbjct: 440  FCVELAVPVGPVH--WLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDC 497

Query: 576  RARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635
            +       S P  P     L PP  P    R++     +             S PP   +
Sbjct: 498  QTSTQFCVSAPRKPP----LQPPVDPVVKARMESSVILSW------------SPPPHGER 541

Query: 636  LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695
             +  D  +      G    T   C     V   P L   ++      EEG +    S AL
Sbjct: 542  PVTIDGYLVEKKKLG--TYTWIRCHEAEWVA-TPELTVADV-----AEEGNFQFRVS-AL 592

Query: 696  GNASTSATFNGQATV-----LAI-APSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRN 747
             +   S       TV     LA+  P   +Q  EG E   + +++  +AG      WF +
Sbjct: 593  NSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVASAGE-----WFLD 647

Query: 748  G-VLWAQGPLE-----TVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPP----D 797
            G  L A    E     T   L +    A+L+  ++   A   + + + + V   P    +
Sbjct: 648  GQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANG-IESSIRMEVRAAPGLTAN 706

Query: 798  RPKLSALLD-MGQGHM-ALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAE 855
            +P  +A  + + + H  A  +  +  +  A+  L  G  L   S GP      +++ +A 
Sbjct: 707  KPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTL---SPGP------KYEVQAS 757

Query: 856  ANSLKLEVRELGLGDSGSYRCEA--------TNVLGSSNTSLFFQVRGAWVQ-VSPSPEL 906
            A    L VR++   D+G Y C +         +V G +   L   + G+ V  V+  P  
Sbjct: 758  AGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLAR-FLHKDMAGSCVDAVAGGPAQ 816

Query: 907  QEGQAVVLSCQVHTGVPEGTSYRWYRDGQP--------LQESTSATLRFAAITLTQ--AG 956
             E +       VH          WY+DG          LQE      R  A T+T+   G
Sbjct: 817  FECETSEAHVHVH----------WYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEG 866

Query: 957  AYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLR 1016
             Y C+    G  +      +S       +       +    G    L C V         
Sbjct: 867  TYSCRV---GEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVTW 923

Query: 1017 LLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQA 1076
               G +L             SS ++ +     T RL +  A   D G Y CEA    G  
Sbjct: 924  YKDGKKL------------SSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEA----GGQ 967

Query: 1077 SASADFDAQAVNV-----QVWPGATVRE-GQLVNLTCLVWTTHPAQLTYTWYQDGQQ--- 1127
              S   D +   V     QV       E G    L+C V     AQ    WY+DG++   
Sbjct: 968  RLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSCEV---AQAQTEVMWYKDGKKLSS 1024

Query: 1128 RLDAH--------SIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY 1179
             L  H         + +      DA  Y C     G+       IT   +   +   +  
Sbjct: 1025 SLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEA--RGQRVSFRLHITEPKMMFAKEQSVHN 1082

Query: 1180 LLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVP---NTLRLELRGPQPRDE 1236
             +++  G  A++ C V ++   ++     G+ L+SS+   +     T RL L      D 
Sbjct: 1083 EVQAEAGASAMLSCEV-AQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADA 1141

Query: 1237 GFYSCSARSPLGQANTSLELRLEGVRVILAPEAA----VPEGAPITVTCADPAAHAPTLY 1292
            G YSC A    G    S  L +   + + A E +    V   A  T   +   A   T  
Sbjct: 1142 GEYSCEA----GGQRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEV 1197

Query: 1293 TWYHNGRWLQEGPAASLSFLVATR---------AHAGAYSCQAQDAQGTRSSRPAALQVL 1343
            TWY +G+ L       +     TR         A AG YSC+A   + +        + +
Sbjct: 1198 TWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEPKAV 1257

Query: 1344 YAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403
            +A +  V +  R + A + A + C V ++   E+    DGK L++SS V   A+G     
Sbjct: 1258 FAKEQLVHNEVR-TEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRIEAAG----- 1310

Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNL 1463
              R  +  Q     AG+ T     Q L   +       V     +A   +    GA   L
Sbjct: 1311 CMRQLVVQQAGQADAGEYTCEAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATL 1370

Query: 1464 SCRLLGGPGPVGNSTFAWFWNDRRLHAEP---------VPTLAFTHVARAQAGMYHCLAE 1514
            SC +      V      W+ + ++L +              L      +A  G Y C A 
Sbjct: 1371 SCEVAQAQTEV-----TWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAG 1425

Query: 1515 LPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVA 1574
                + +      +V++  + P     V+ + G    L C V       +    G +L  
Sbjct: 1426 GQRLSFSLDVAEPKVVFAKEQPVHRE-VQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSF 1484

Query: 1575 SSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASN 1617
            SS+         + + A     R+ ++    +  GEY C A +
Sbjct: 1485 SSK---------VRMEAVGCTRRLVVQQAGQAVAGEYSCEAGS 1518



 Score = 94.7 bits (234), Expect = 7e-19
 Identities = 362/1685 (21%), Positives = 573/1685 (34%), Gaps = 282/1685 (16%)

Query: 78   LVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTE 137
            L+E R  G+ +   + E     L +  L+  DS +Y      ++      V+G  V + E
Sbjct: 2952 LLELRASGKHQ--PSQEGLTLRLTISALEKADSDTYTCDIGQAQSRAQLLVQGRRVHIIE 3009

Query: 138  EPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQW-QGQDPARSVTFNSQKFEPTGV 196
            +         V++ EG+   F C    +       + W   + P  +   N    +P G 
Sbjct: 3010 D------LEDVDVQEGSSATFRCR---ISPANYEPVHWFLDKTPLHANELNEIDAQPGGY 3060

Query: 197  GHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGE 256
             H+ TL   ++ +D G I        + RA + + +  K +    ++    +   I  GE
Sbjct: 3061 -HVLTLRQ-LALKDSGTIY---FEAGDQRASAALRVTEKPSVFSREL----TDATITEGE 3111

Query: 257  LVTLTCQVNSSYPAVSSIKWLKDGVRLQTKT----------GVLHLPQAAWSDAGVYTCQ 306
             +TL C+ ++    V    W KDG  L+               L +  A   D+G Y C+
Sbjct: 3112 DLTLVCETSTCDIPVC---WTKDGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKCE 3168

Query: 307  AENGVGSLV----SPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYK 362
            A     S +    + P+     + +++V      LE    TL C   + A       W  
Sbjct: 3169 AGGACSSSIVRVHARPVRFQEALKDLEV------LEGGAATLRCVLSSVAAP---VKWCY 3219

Query: 363  NHVLLEDAHSHTLR-----LHLATR----ADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413
             + +L     ++LR     L L  R     D+G Y C      G + +     V   P  
Sbjct: 3220 GNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSF----GDQTTSATLTVTALPAQ 3275

Query: 414  TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNS 473
                    E   G    L C +     A +    G   L    GD     R+        
Sbjct: 3276 FIGKLRNKEATEGATATLRCEL--SKAAPVEWRKGSETLRD--GD-----RYCLRQDGAM 3326

Query: 474  LRLEIRDLEETDSGEYKCSATNSLGNATSTL-DFHANAARLLISPAAEVVEGQAVTLSCR 532
              L+IR L   D+ EY C       +A+ T+    A+    L     E +EG   TL C 
Sbjct: 3327 CELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFIGRL--RHQESIEGATATLRCE 3384

Query: 533  SGLSPTPDARFSWYLNGALLHEGPGSSLLLPAA---------SSTDAGSYHCRARDGHSA 583
               +    A   W      L +G   SL    A         +  DAG Y C   +  ++
Sbjct: 3385 LSKA----APVEWRKGRESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSCVCGEERTS 3440

Query: 584  SGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVV 643
                  A LTV   P +  FT  L  + A  GA    +L C +    P         R  
Sbjct: 3441 ------ATLTVKALPAK--FTEGLRNEEAVEGA--TAMLWCELSKVAPVEW------RKG 3484

Query: 644  ATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSAT 703
              +L  G           R  + +      ++I    + + G YLC      G   TSAT
Sbjct: 3485 PENLRDG----------DRYILRQEGTRCELQICGLAMADAGEYLC----VCGQERTSAT 3530

Query: 704  FNGQ---ATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSW------FRNG---VLW 751
               +   A  +    +   +EG  A L C ++     S A   W       R+G    L 
Sbjct: 3531 LTIRALPARFIEDVKNQEAREGATAVLQCELN-----SAAPVEWRKGSETLRDGDRYSLR 3585

Query: 752  AQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGH 811
              G    + +  +A  D   Y+C    E  + + T   L + +        A     +G 
Sbjct: 3586 QDGTKCELQIRGLAMADTGEYSCVCGQERTSAMLTVRALPIKFTEGLRNEEAT----EGA 3641

Query: 812  MALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDS 871
             A+  C +    +A +  + G   L            R   + +    +L++R L   D+
Sbjct: 3642 TAVLRCELSK--MAPVEWWKGHETLRDG--------DRHSLRQDGARCELQIRGLVAEDA 3691

Query: 872  GSYRCEATNVLGSSNTSLFFQVR---GAWVQVSPSPELQEGQAVVLSCQVHTGVPE--GT 926
            G Y C    + G   TS    VR     +++   + E  EG    L C++    P     
Sbjct: 3692 GEYLC----MCGKERTSAMLTVRAMPSKFIEGLRNEEATEGDTATLWCELSKAAPVEWRK 3747

Query: 927  SYRWYRDGQP---LQESTSATLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSY 982
             +   RDG      Q+ +   L+   + +  AG Y C   Q   SAT ++ A        
Sbjct: 3748 GHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTSATLTVRA-------L 3800

Query: 983  APRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLH 1042
              R +      +   G   +L C +    P +       R  + TL+G         R  
Sbjct: 3801 PARFIEDVKNQEAREGATAVLQCELSKAAPVEW------RKGSETLRG-------GDRYS 3847

Query: 1043 VAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQA---VNVQVWPGATVRE 1099
            +        L+IHG  + D G Y C      GQ   SA    +A   V  +        E
Sbjct: 3848 LRQDGTRCELQIHGLSVADTGEYSC----VCGQERTSATLTVRAPQPVFREPLQSLQAEE 3903

Query: 1100 GQLVNLTC--------LVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGV 1151
            G    L C        +VW+    QL     ++ + +     + L ++   D   Y C  
Sbjct: 3904 GSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTC 3963

Query: 1152 GPPGRAPRLSRPITLDVLYAP-RNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAG- 1209
            G    +       TL V  AP R LR     E   G  A + C + SR  A +       
Sbjct: 3964 GSQATS------ATLTVTAAPVRFLRELQHQEVDEGGTAHLCCEL-SRAGASVEWRKGSL 4016

Query: 1210 RLLASSTAASVPNTLRLEL--RGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP 1267
            +L   +    V +    EL  RG +  D G Y+C       Q+  SL +R+   +     
Sbjct: 4017 QLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHT--QSMASLSVRVPRPKFKTRL 4074

Query: 1268 EAAVPEGAPITVTCADPA-AHAPTLYTWYHNGRWLQEGPAASLSFLVATR---------A 1317
            ++   E   I   C   + A +  +  W   G  L  GP   +    ATR          
Sbjct: 4075 QSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEAK 4134

Query: 1318 HAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQ--CTVDSEPPA 1375
              G Y+C       T   + AA   +  P+  ++    D+   +   ++  C V      
Sbjct: 4135 DTGEYACV------TGGQKTAASLRVTEPEVTIVRGLVDAEVTADEDVEFSCEVSRAGAT 4188

Query: 1376 ELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQ-VQDVPAGDDTYVCTAQNLLGSI 1434
             +     G  L  S+ V  +A   G +    + LRL+ V    AG      T    LG+ 
Sbjct: 4189 GVQWCLQGLPL-QSNEVTEVAVRDGRI----HTLRLKGVTPEDAG------TVSFHLGNH 4237

Query: 1435 STIGRLQVEGARV-VAEPGLDV--PEGAALNLSCRLLGGPGPV------GNSTFAWFWND 1485
            ++  +L V    V + EP  DV   EG   +  CRL    G        G    A   ND
Sbjct: 4238 ASSAQLTVRAPEVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMND 4297

Query: 1486 RRLHAEPVPTLAFTHVARAQAG--MYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVE 1543
              +    +  L    V    AG   +H           S+   L+V         +  VE
Sbjct: 4298 ITVEQGTLHLLTLHKVTLEDAGTVSFHV-------GTCSSEAQLKVTAKNTVVRGLENVE 4350

Query: 1544 PEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALR--VDIE 1601
               G   + +C++    +A+ T  L    V +S+        +  V+   N LR  + ++
Sbjct: 4351 ALEGGEALFECQLSQPEVAAHTWLLDDEPVHTSE--------NAEVVFFENGLRHLLLLK 4402

Query: 1602 ALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGL--LLLLLGL 1659
             LRP D     C  + + G   TS +  VR            W L +L  L    +  G 
Sbjct: 4403 NLRPQDS----CRVTFLAGDMVTSAFLTVRG-----------WRLEILEPLKNAAVRAGA 4447

Query: 1660 GACYT 1664
             AC+T
Sbjct: 4448 QACFT 4452



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 282/1247 (22%), Positives = 418/1247 (33%), Gaps = 244/1247 (19%)

Query: 508  ANAARLLISPAAEVVE-GQAVTLSCRSGLSPTPDARFSWYLN------GA---LLHEGPG 557
            + A R L  P A VV  G+  TLSC+   +PTP    SW  +      GA   L  +G  
Sbjct: 7    SGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQV--SWEKDQQPVAAGARFRLAQDGDL 64

Query: 558  SSLLLPAASSTDAGSYHCRARD--GHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAG 615
              L +   +  D+G Y CRAR+  G + +              + P F  R    +    
Sbjct: 65   YRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPT--SIRVR 122

Query: 616  AGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVE 675
             G      CRV   P   +      R +    P G          PR++V +      + 
Sbjct: 123  EGSEATFRCRVGGSPRPAVSWSKDGRRLGE--PDG----------PRVRVEELGEASALR 170

Query: 676  IHNPLLEEEGLYLCEASNALGNASTSA----------TFNGQATVLAIAPSH-------- 717
            I      + G Y   A N LG AS +A          T +   T  A   +H        
Sbjct: 171  IRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAM 230

Query: 718  -----------------TLQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETV- 759
                             T+ EG  A L+C V+ E         W ++G L  +G    V 
Sbjct: 231  RAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETV---WKKDGQLVTEGRRHVVY 287

Query: 760  ---------TLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP--PDRPKLSALLDMG 808
                      +L   ++D  LY C      G Q  + VL+ V  P  P + +L   L++ 
Sbjct: 288  EDAQENFVLKILFCKQSDRGLYTCTASNLVG-QTYSSVLVVVREPAVPFKKRLQD-LEVR 345

Query: 809  QGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGL 868
            +   A F+C V  +P    A F  E  L  S         ++  + E    +L VR +  
Sbjct: 346  EKESATFLCEV-PQPSTEAAWFKEETRLWAS--------AKYGIEEEGTERRLTVRNVSA 396

Query: 869  GDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSY 928
             D   Y CE       S T     V+G  ++  P           + C V   VP G  +
Sbjct: 397  DDDAVYICETPE---GSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFC-VELAVPVGPVH 452

Query: 929  RWYRDGQPL---------QESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLH 979
             W R+ + +          E T  TL  +   L   G     A   G   TS    +S  
Sbjct: 453  -WLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMA---GDCQTSTQFCVS-- 506

Query: 980  VSYAPRHVTLTTLMD-TGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSS 1038
               APR   L   +D     R+   +    S PP      HG+R V  T+ G    +   
Sbjct: 507  ---APRKPPLQPPVDPVVKARMESSVILSWSPPP------HGERPV--TIDGYLVEKKKL 555

Query: 1039 P-----RLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWP 1093
                  R H A    T  L +     E    +   A N+ GQ S   +F      V + P
Sbjct: 556  GTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQ-SPYLEFPG---TVHLAP 611

Query: 1094 GATVR---------EGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSI-------PLP 1137
               VR         EG  V  +  +      +    W+ DG Q L A S+          
Sbjct: 612  KLAVRTPLKAVQAVEGGEVTFSVDLTVASAGE----WFLDG-QALKASSVYEIHCDRTRH 666

Query: 1138 NVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAP-----------------RNLRLTYL 1180
             +T+R+  +   G      A  +   I ++V  AP                 R      L
Sbjct: 667  TLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQL 726

Query: 1181 LESHGGQLALVLCTVDSRP----PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDE 1236
            L     Q A V    D R     P     + AGR +             L +R     D 
Sbjct: 727  LAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRV-------------LLVRDVARDDA 773

Query: 1237 GFYSCSARSPLGQANTSLELRLEGVRVILAPEAA-----VPEGAPITVTCADPAAHAPTL 1291
            G Y C +R        + +L ++G+   L  + A        G P    C    AH    
Sbjct: 774  GLYECVSRG----GRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPAQFECETSEAHVHV- 828

Query: 1292 YTWYHNG--------RWLQE--GPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQ 1341
              WY +G        R+LQE  G    L     TR   G YSC+  +       R +  +
Sbjct: 829  -HWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPK 887

Query: 1342 VLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGH 1401
            V++A +       + + A + A + C V ++   E+    DGK L++SS V   A+G   
Sbjct: 888  VVFAKEQLARRKLQ-AEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVCMEATG--- 942

Query: 1402 VQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAAL 1461
                R  +  Q     AG+ +     Q L   +       V     VA   +    GA+ 
Sbjct: 943  --CTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASA 1000

Query: 1462 NLSCRLLGGPGPVGNSTFAWFWNDRRL------HAEPV---PTLAFTHVARAQAGMYHCL 1512
             LSC +      V      W+ + ++L      H E       L      +  AG Y C 
Sbjct: 1001 TLSCEVAQAQTEV-----MWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCE 1055

Query: 1513 AELPTGAAASAPVMLRVLYP----PKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHL 1568
            A             L +  P     K  ++   V+ E G   +L C V ++    +T + 
Sbjct: 1056 AR-----GQRVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEV-AQAQTEVTWYK 1109

Query: 1569 GSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSA 1615
              + ++SS   G   +     L  P A +        +D GEY C A
Sbjct: 1110 DGKKLSSSSKVGMEVKGCTRRLVLPQAGK--------ADAGEYSCEA 1148



 Score = 81.6 bits (200), Expect = 6e-15
 Identities = 277/1174 (23%), Positives = 409/1174 (34%), Gaps = 187/1174 (15%)

Query: 255  GELVTLTCQVNSSYPAVSSIKW------LKDG----VRLQTKTGVLHLPQAAWSDAGVYT 304
            G    L C+++     V+ ++W      L+DG    +R +     L +   A +DAG Y 
Sbjct: 3464 GATAMLWCELSK----VAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYL 3519

Query: 305  CQA--ENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYK 362
            C    E    +L    +    F+ +V+   A    E  T  L C   + AP +    W K
Sbjct: 3520 CVCGQERTSATLTIRALPAR-FIEDVKNQEAR---EGATAVLQCELNSAAPVE----WRK 3571

Query: 363  NHVLLEDAHSHTLR---------LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413
                L D   ++LR         +     ADTG Y C    V G ER+  +  V   P  
Sbjct: 3572 GSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAMLTVRALPIK 3627

Query: 414  TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSD-HSPRFSGTSGPN 472
                    E   G   +L C +           H       T  D D HS R  G     
Sbjct: 3628 FTEGLRNEEATEGATAVLRCELSKMAPVEWWKGH------ETLRDGDRHSLRQDGAR--- 3678

Query: 473  SLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA-AEVVEGQAVTLSC 531
               L+IR L   D+GEY C       +A  T+   A  ++ +      E  EG   TL C
Sbjct: 3679 -CELQIRGLVAEDAGEYLCMCGKERTSAMLTV--RAMPSKFIEGLRNEEATEGDTATLWC 3735

Query: 532  R-SGLSPTPDARFSWYLNG----ALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGP 586
              S  +P    +    L      +L  +G    L +   +  DAG Y C      ++   
Sbjct: 3736 ELSKAAPVEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTS--- 3792

Query: 587  SSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATS 646
               A LTV   P +  F    D+    A  G   +L C +    P   +           
Sbjct: 3793 ---ATLTVRALPAR--FIE--DVKNQEAREGATAVLQCELSKAAPVEWRK---------- 3835

Query: 647  LPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNG 706
                 G  T  G   R  + +      ++IH   + + G Y C      G   TSAT   
Sbjct: 3836 -----GSETLRG-GDRYSLRQDGTRCELQIHGLSVADTGEYSC----VCGQERTSATLTV 3885

Query: 707  QATVLAIA-PSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRNGV-LWAQGPLET---- 758
            +A       P  +LQ  EG+ A L C +S   A       W + G+ L A G  E     
Sbjct: 3886 RAPQPVFREPLQSLQAEEGSTATLQCELSEPTA----TVVWSKGGLQLQANGRREPRLQG 3941

Query: 759  ----VTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMAL 814
                + L  + R D   Y C      G+Q ++  L     P    +     ++ +G  A 
Sbjct: 3942 CTAELVLQDLQREDTGEYTCT----CGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAH 3997

Query: 815  FICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSY 874
              C + SR  A +    G   L            ++Q   +  + +L VR +   D+G Y
Sbjct: 3998 LCCEL-SRAGASVEWRKGSLQLFPC--------AKYQMVQDGAAAELLVRGVEQEDAGDY 4048

Query: 875  RCEATNVLGSSNTSLFFQV-RGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRD 933
             C+  +    S  SL  +V R  +     S E + G    L CQ+ +    G   +W ++
Sbjct: 4049 TCDTGHT--QSMASLSVRVPRPKFKTRLQSLEQETGDIARLCCQL-SDAESGAVVQWLKE 4105

Query: 934  GQPLQESTSATLRFAAITLTQAGAYHCQAQAPGS---ATTSLAAPISLHVSYAPRHVTLT 990
            G  L       +R    T  +   +  +A+  G     T       SL V+     VT+ 
Sbjct: 4106 GVELHAGPKYEMRSQGAT-RELLIHQLEAKDTGEYACVTGGQKTAASLRVTEP--EVTIV 4162

Query: 991  TLMDTGPGRLGLLLCRVDSDPPAQLRL---LHGDRLVASTLQGVGGPEGSSPRLHVAVAP 1047
                      GL+   V +D   +        G   V   LQG+  P  S+    VAV  
Sbjct: 4163 R---------GLVDAEVTADEDVEFSCEVSRAGATGVQWCLQGL--PLQSNEVTEVAVRD 4211

Query: 1048 NTLR-LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWP---GATVREGQLV 1103
              +  L + G   ED G      S  LG  ++SA    +A  V +        + EGQ  
Sbjct: 4212 GRIHTLRLKGVTPEDAGT----VSFHLGNHASSAQLTVRAPEVTILEPLQDVQLSEGQDA 4267

Query: 1104 NLTCLV---------WTTHPAQLTYTWYQD-GQQRLDAHSIPLPNVTVRDATSYRCGVGP 1153
            +  C +         W      L      D   ++   H + L  VT+ DA +    VG 
Sbjct: 4268 SFQCRLSRASGQEARWALGGVPLQANEMNDITVEQGTLHLLTLHKVTLEDAGTVSFHVGT 4327

Query: 1154 PGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLA 1213
                 +L       V+    N+      E+  G  AL  C +     A          + 
Sbjct: 4328 CSSEAQLKVTAKNTVVRGLENV------EALEGGEALFECQLSQPEVAAHTWLLDDEPVH 4381

Query: 1214 SSTAASV---PNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRV-ILAP 1267
            +S  A V    N LR  L L+  +P+D    SC      G   TS  L + G R+ IL P
Sbjct: 4382 TSENAEVVFFENGLRHLLLLKNLRPQD----SCRVTFLAGDMVTSAFLTVRGWRLEILEP 4437

Query: 1268 --EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQ----------EGPAASLSFLVAT 1315
               AAV  GA    TC    A      +WY NG  +Q          +G   +L    A 
Sbjct: 4438 LKNAAVRAGAQACFTCTLSEAVPVGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSAQ 4497

Query: 1316 RAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDA 1349
              HAG  +   +DA    S+R   L +   P+DA
Sbjct: 4498 PHHAGEVTFACRDA--VASARLTVLGLPDPPEDA 4529



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 299/1338 (22%), Positives = 457/1338 (34%), Gaps = 238/1338 (17%)

Query: 225  RAQSEIHLQVKYAPKGVKILLSP-SGRNILPGELVTLTCQVNSSYPAVSSIKWLKDG--- 280
            +++S   L V   P  +   L P +GR +   + V L+C      PA  +++W KD    
Sbjct: 2455 KSRSSARLVVSDIPVVLTRPLEPKTGREL---QSVVLSCDFR---PAPKAVQWYKDDTPL 2508

Query: 281  -------VRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPA 333
                   + L+ +   L + +   +DAGVY CQA    GS  S   S  + +   +V+  
Sbjct: 2509 SPSEKFKMSLEGQMAELRILRLMPADAGVYRCQA----GSAHS---STEVTVEAREVTVT 2561

Query: 334  GPI-----LENQTVTLVCNTPNEAPSDLRYSWYKN---------HVLLEDAHSHTLRLHL 379
            GP+      E    +  C   +E   D    W  N         H +      HTL L  
Sbjct: 2562 GPLQDAEATEEGWASFSCELSHE---DEEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKS 2618

Query: 380  ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEP 439
              RAD G        V  S R   + V V        L      + G +  L C  VS+P
Sbjct: 2619 IQRADAGIVRASSLKVSTSAR---LEVRVKPVVFLKALDDLSAEERGTLA-LQCE-VSDP 2673

Query: 440  LATLVLSHGGHILA-STSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG 498
             A +V    G  L  S   D  H+   +GT G     L + D+   D+G Y C   +   
Sbjct: 2674 EAHVVWRKDGVQLGPSDKYDFLHT---AGTRG-----LVVHDVSPEDAGLYTCHVGSEET 2725

Query: 499  NATSTL-DFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALL----- 552
             A   + D H    + L     EV+EG++ +  C        D    W + G  +     
Sbjct: 2726 RARVRVHDLHVGITKRL--KTMEVLEGESCSFECVLSHESASDPAM-WTVGGKTVGSSSR 2782

Query: 553  ----HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLD 608
                 +G    L++  A+ +DAG          S  G +S A L V    R+        
Sbjct: 2783 FQATRQGRKYILVVREAAPSDAGEV------VFSVRGLTSKASLIV----RERPAAIIKP 2832

Query: 609  LDAAGAGAGRRGLLLCRVD-SDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTK 667
            L+      G    L C +  +  P       KDR                  S +  V  
Sbjct: 2833 LEDQWVAPGEDVELRCELSRAGTPVHWL---KDRKAIRK-------------SQKYDVVC 2876

Query: 668  APNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANL 727
               +  + I    L++ G Y CE   +   AS             +      ++GT A  
Sbjct: 2877 EGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEELTNLQVEEKGT-AVF 2935

Query: 728  TCNVSREAAGSPANFSWFRNGVL----------WAQGPLETVTLLPVARTDAALYACRIL 777
            TC     A    A  +W R G+L            +G    +T+  + + D+  Y C I 
Sbjct: 2936 TCKTEHPA----ATVTW-RKGLLELRASGKHQPSQEGLTLRLTISALEKADSDTYTCDI- 2989

Query: 778  TEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLA 837
                AQ    +L+          L   +D+ +G  A F C +        A +   H   
Sbjct: 2990 --GQAQSRAQLLVQGRRVHIIEDLED-VDVQEGSSATFRCRISP------ANYEPVHWFL 3040

Query: 838  TSLGPQVPSHGRFQAKAEANS---LKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894
                 + P H     + +A       L +R+L L DSG+   EA    G    S   +V 
Sbjct: 3041 ----DKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEA----GDQRASAALRVT 3092

Query: 895  ---GAWVQVSPSPELQEGQAVVLSCQVHT-GVPEGTSYRWYRDGQPLQ---------EST 941
                 + +      + EG+ + L C+  T  +P      W +DG+ L+         E  
Sbjct: 3093 EKPSVFSRELTDATITEGEDLTLVCETSTCDIP----VCWTKDGKTLRGSARCQLSHEGH 3148

Query: 942  SATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLG 1001
             A L     TL  +G Y C  +A G+ ++S+    +  V +      L  L     G   
Sbjct: 3149 RAQLLITGATLQDSGRYKC--EAGGACSSSIVRVHARPVRFQEALKDLEVL----EGGAA 3202

Query: 1002 LLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061
             L C V S   A ++  +G+ ++    +     EG+            L L +     +D
Sbjct: 3203 TLRC-VLSSVAAPVKWCYGNNVLRPGDKYSLRQEGA-----------MLELVVRNLRPQD 3250

Query: 1062 EGVYICE-----ASNTLGQASASADFDAQAVNVQVWPGATVR-EGQLVNLTCLVWTTHPA 1115
             G Y C       S TL   +  A F  +  N +   GAT     +L     + W     
Sbjct: 3251 SGRYSCSFGDQTTSATLTVTALPAQFIGKLRNKEATEGATATLRCELSKAAPVEWRKGSE 3310

Query: 1116 QL----TYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYA 1171
             L     Y   QDG        + +  + + DA  Y C  G      R S  +T+  + A
Sbjct: 3311 TLRDGDRYCLRQDGAM----CELQIRGLAMVDAAEYSCVCG----EERTSASLTIRPMPA 3362

Query: 1172 PRNLRLTYLLESHGGQLALVLCTVDSRPPAQL-----ALSHAGRLLASSTAASVPNTLRL 1226
                RL +  ES  G  A + C +    P +      +L    R       A       L
Sbjct: 3363 HFIGRLRH-QESIEGATATLRCELSKAAPVEWRKGRESLRDGDRHSLRQDGA----VCEL 3417

Query: 1227 ELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVI----LAPEAAVPEGAPITVTC- 1281
            ++ G    D G YSC      G+  TS  L ++ +       L  E AV EGA   + C 
Sbjct: 3418 QICGLAVADAGEYSCVC----GEERTSATLTVKALPAKFTEGLRNEEAV-EGATAMLWCE 3472

Query: 1282 ---ADPAAHAPTLYTWYHNGRWL--QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSR 1336
                 P              R++  QEG    L       A AG Y C           R
Sbjct: 3473 LSKVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYLCVC------GQER 3526

Query: 1337 PAALQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHDGKVLATSSGVHS 1394
             +A   + A     +   ++  AR  + AV+QC ++S  P E              G  +
Sbjct: 3527 TSATLTIRALPARFIEDVKNQEAREGATAVLQCELNSAAPVE-----------WRKGSET 3575

Query: 1395 LASGTGH-VQVARNALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQVEGARVVAEPG 1452
            L  G  + ++       LQ++ +   D   Y C    + G   T   L V    +    G
Sbjct: 3576 LRDGDRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAMLTVRALPIKFTEG 3631

Query: 1453 L---DVPEGAALNLSCRL 1467
            L   +  EGA   L C L
Sbjct: 3632 LRNEEATEGATAVLRCEL 3649



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 313/1506 (20%), Positives = 499/1506 (33%), Gaps = 280/1506 (18%)

Query: 255  GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYT 304
            G   TL+C+V     A + + W KDG +L   + V          L + QA  + AG Y+
Sbjct: 1457 GASTTLSCEVAQ---AQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYS 1513

Query: 305  CQAENGVGSLVSPPISLHIFMAEVQV-----SPAGPILENQTVTLVCNTPNEAPSDLRYS 359
            C+A        S  +S H+ +AE +       PA   ++ +  T    +   A +    +
Sbjct: 1514 CEAG-------SQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATLSCEVAQAQTEVT 1566

Query: 360  WYKNHVLLEDAH---------SHTLRLHLATRADTGFYFCEVQN------VHGSERSGPV 404
            WYK+   L  +          +  L +  A +AD G Y C+  +      +H +E   P 
Sbjct: 1567 WYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHVAE---PK 1623

Query: 405  SVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPR 464
             V     P    + A    +AG    L C V            G  + +S+        +
Sbjct: 1624 VVFAKEQPAHREVQA----EAGASATLSCEVAQAQTEVTWYKDGKKLSSSS--------K 1671

Query: 465  FSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAA----- 519
                +   + RL ++   + D+GEY C A    G    +   H       IS        
Sbjct: 1672 VRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQRLSFRLHVAELEPQISERPCRREP 1727

Query: 520  -EVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH---------EGPGSSLLLPAASSTD 569
              V E + + L+    L+    A  +W  +G  +          +G   +L +  A   D
Sbjct: 1728 LVVKEHEDIILTAT--LATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLD 1785

Query: 570  AGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSD 629
            +  Y CR      A G   P  +  +          RL L+      G    L C +   
Sbjct: 1786 SAIYSCRV----GAEGQDFPVQVEEVAAK-----FCRL-LEPVCGELGGTVTLACELS-- 1833

Query: 630  PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLC 689
             PA  +++   R   T L  G           R ++     +  + +     E+ G Y+C
Sbjct: 1834 -PACAEVVW--RCGNTQLRVG----------KRFQMVAEGPVRSLTVLGLRAEDAGEYVC 1880

Query: 690  EASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV 749
            E+ +   +A  + +       ++   +   +EG EA   C VS     S     WFR+G 
Sbjct: 1881 ESRDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVVSP----SDVAVVWFRDGA 1936

Query: 750  LWAQGPLETVTLLPVARTDAALYACRILTEAGA------QLSTPVLLSVLYPPDRPKLSA 803
            L    P E   +     + +   +  +L +AG         S+   L V   P   K   
Sbjct: 1937 LLQ--PSEKFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKL 1994

Query: 804  LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
                 +   ++ +    +RP   L        LA   G  V  H      AE    +L +
Sbjct: 1995 EPQTVEERSSVTLEVELTRPWPELRWTRNATALAP--GKNVEIH------AEGARHRLVL 2046

Query: 864  RELGLGDSGSYRCEATNVLGSSNTSLFFQVRGA-WVQVSPSPELQEGQAVVLSCQVHTGV 922
              +G  D G + CE  +    +   L  ++R    V+   + E +E     +  Q+    
Sbjct: 2047 HNVGFADRGFFGCETPD--DKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQLSHAD 2104

Query: 923  PEGTSYRWYRDGQPLQESTSATL--RFAAITLTQAGAYHCQA-----QAPGSATTSLAAP 975
             +G+   W RDG   Q+  +  L  R    TLT +G     +     +A G  T++    
Sbjct: 2105 VDGS---WTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKAEGVHTSARLVV 2161

Query: 976  ISLHVSYA-PRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034
              L VS++ P    +TT  +        L C + S P   +R L           GV   
Sbjct: 2162 TELPVSFSRPLQDVVTTEKEKVT-----LECEL-SRPNVDVRWLK---------DGVELR 2206

Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASA---------------- 1078
             G +  + +A       L I+     D+GVY+C+A +    AS                 
Sbjct: 2207 AGKT--MAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLA 2264

Query: 1079 -----------SADFDAQAVNVQVWPGATVR--------EGQLVNLTCLVWTTHPAQLTY 1119
                       +A+  AQ + V+  P   VR        E     L C V     A    
Sbjct: 2265 EDAGEIQFVAENAESRAQ-LRVKELPVTLVRPLRDKIAMEKHRGVLECQV---SRASAQV 2320

Query: 1120 TWYQDGQQRLDA-----------HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV 1168
             W++  Q+                 + + +V   D  +Y C  G    + +    +    
Sbjct: 2321 RWFKGSQELQPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDAGDVKTSAQFF--VEEQS 2378

Query: 1169 LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLEL 1228
            +   R L+   ++E               RPP         + L   T       + LE 
Sbjct: 2379 ITIVRGLQDVTVMEPAPAWFECETSIPSVRPP---------KWLLGKTVLQAGGNVGLEQ 2429

Query: 1229 RGPQPRDEGFYSCSARS-----PLGQANTSLELRLEGVRVILAPEAAVPEGAPI-TVTCA 1282
             G   R     +CS  +      +G++ +S  L +  + V+L        G  + +V  +
Sbjct: 2430 EGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPLEPKTGRELQSVVLS 2489

Query: 1283 DPAAHAPTLYTWYHNGRWLQ---------EGPAASLSFLVATRAHAGAYSCQAQDAQGTR 1333
                 AP    WY +   L          EG  A L  L    A AG Y CQA  A  + 
Sbjct: 2490 CDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHSST 2549

Query: 1334 SSRPAALQVLYAPQDAVLSSFRDSRA--RSMAVIQCTVDSEPPAELALSHDGKVLATSSG 1391
                 A +V       V    +D+ A     A   C +  E   E+  S +G  L   S 
Sbjct: 2550 EVTVEAREV------TVTGPLQDAEATEEGWASFSCELSHE-DEEVEWSLNGMPLYNDSF 2602

Query: 1392 VHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEP 1451
                  G  H  V ++  R          D  +  A +L   +ST  RL+V    VV   
Sbjct: 2603 HEISHKGRRHTLVLKSIQRA---------DAGIVRASSL--KVSTSARLEVRVKPVVFLK 2651

Query: 1452 GLD---VPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQ--- 1505
             LD     E   L L C +      V        W    +   P     F H A  +   
Sbjct: 2652 ALDDLSAEERGTLALQCEVSDPEAHV-------VWRKDGVQLGPSDKYDFLHTAGTRGLV 2704

Query: 1506 --------AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVD 1557
                    AG+Y C        A      L V    +  TM V          +L     
Sbjct: 2705 VHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHESA 2764

Query: 1558 SEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASN 1617
            S+P A  T  +G + V SS    A  +   ++L         +    PSD GE + S   
Sbjct: 2765 SDP-AMWT--VGGKTVGSSSRFQATRQGRKYILV--------VREAAPSDAGEVVFSVRG 2813

Query: 1618 VLGSAS 1623
            +   AS
Sbjct: 2814 LTSKAS 2819



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 266/1211 (21%), Positives = 410/1211 (33%), Gaps = 218/1211 (18%)

Query: 509  NAARLLISPAAEVV----------EGQAVTLSCRSGLSPTPDARFSWYLNGALLH----- 553
            ++ARL++S    V+          E Q+V LSC     P P A   WY +   L      
Sbjct: 2458 SSARLVVSDIPVVLTRPLEPKTGRELQSVVLSC--DFRPAPKA-VQWYKDDTPLSPSEKF 2514

Query: 554  ----EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDL 609
                EG  + L +      DAG Y C+A   HS++         V    R+ T T  L  
Sbjct: 2515 KMSLEGQMAELRILRLMPADAGVYRCQAGSAHSST--------EVTVEAREVTVTGPLQ- 2565

Query: 610  DAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAP 669
            DA     G                 +L H+D  V  SL    G          +      
Sbjct: 2566 DAEATEEGWASF-----------SCELSHEDEEVEWSL---NGMPLYNDSFHEISHKGRR 2611

Query: 670  NLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTC 729
            + L ++  +    + G+    +     +A           + A+      + GT A L C
Sbjct: 2612 HTLVLK--SIQRADAGIVRASSLKVSTSARLEVRVKPVVFLKALDDLSAEERGTLA-LQC 2668

Query: 730  NVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVART-----------DAALYACRILT 778
             VS       A+  W ++GV    GP +    L  A T           DA LY C + +
Sbjct: 2669 EVS----DPEAHVVWRKDGV--QLGPSDKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGS 2722

Query: 779  EAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLAT 838
            E   +    V +  L+     +L  + ++ +G    F C +     +  A++       T
Sbjct: 2723 E---ETRARVRVHDLHVGITKRLKTM-EVLEGESCSFECVLSHESASDPAMW-------T 2771

Query: 839  SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV 898
              G  V S  RFQA  +     L VRE    D+G        +  +S  SL  + R A +
Sbjct: 2772 VGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGEVVFSVRGL--TSKASLIVRERPAAI 2829

Query: 899  QVSPSPE--LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQ---------ESTSATLRF 947
             + P  +  +  G+ V L C++      GT   W +D + ++         E T A L  
Sbjct: 2830 -IKPLEDQWVAPGEDVELRCELSRA---GTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVI 2885

Query: 948  AAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVT--LTTLMDTGPGRLGLLLC 1005
               +L  AG Y C+ +A  S         SLHV       T  LT L     G   +  C
Sbjct: 2886 RGASLKDAGEYTCEVEASKSTA-------SLHVEEKANCFTEELTNLQVEEKG-TAVFTC 2937

Query: 1006 RVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVY 1065
            + +  P A +    G       L+  G  + S   L       TLRL I      D   Y
Sbjct: 2938 KTE-HPAATVTWRKG----LLELRASGKHQPSQEGL-------TLRLTISALEKADSDTY 2985

Query: 1066 ICEASNTLGQASASADFDAQAVNVQV---WPGATVREGQLVNLTCLVWTTHPAQL-TYTW 1121
             C+    +GQA + A    Q   V +        V+EG      C +    PA      W
Sbjct: 2986 TCD----IGQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSATFRCRI---SPANYEPVHW 3038

Query: 1122 YQDGQ-------QRLDA-----HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVL 1169
            + D           +DA     H + L  + ++D+ +     G      R S  + +   
Sbjct: 3039 FLDKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEAGD----QRASAALRVTEK 3094

Query: 1170 YAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVP---NTLRL 1226
             +  +  LT    + G  L LV  T     P  +  +  G+ L  S    +    +  +L
Sbjct: 3095 PSVFSRELTDATITEGEDLTLVCETSTCDIP--VCWTKDGKTLRGSARCQLSHEGHRAQL 3152

Query: 1227 ELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAA 1286
             + G   +D G Y C A      +   +  R    +  L  +  V EG   T+ C   + 
Sbjct: 3153 LITGATLQDSGRYKCEAGGACSSSIVRVHARPVRFQEAL-KDLEVLEGGAATLRCVLSSV 3211

Query: 1287 HAPTLYTWYHN-------GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAA 1339
             AP  + + +N           QEG    L         +G YSC   D      +  A 
Sbjct: 3212 AAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSFGD-----QTTSAT 3266

Query: 1340 LQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLAS 1397
            L V   P    +   R+  A   + A ++C +    P E              G  +L  
Sbjct: 3267 LTVTALPAQ-FIGKLRNKEATEGATATLRCELSKAAPVE-----------WRKGSETLRD 3314

Query: 1398 GTGHVQVARNAL-RLQVQD---VPAGDDTYVCTAQNLLGSIST-------IGRLQVEGAR 1446
            G  +      A+  LQ++    V A + + VC  +    S++        IGRL+ +   
Sbjct: 3315 GDRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFIGRLRHQ--- 3371

Query: 1447 VVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA----EPVPTLAFTHVA 1502
                   +  EGA   L C  L    PV          D   H+      V  L    +A
Sbjct: 3372 -------ESIEGATATLRCE-LSKAAPVEWRKGRESLRDGDRHSLRQDGAVCELQICGLA 3423

Query: 1503 RAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLA 1562
             A AG Y C+     G   ++  +     P K    +   E   G   +L C +    +A
Sbjct: 3424 VADAGEYSCVC----GEERTSATLTVKALPAKFTEGLRNEEAVEGATAMLWCELSK--VA 3477

Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
             +    G        P+         +        + I  L  +D GEY+C    V G  
Sbjct: 3478 PVEWRKG--------PENLRDGDRYILRQEGTRCELQICGLAMADAGEYLC----VCGQE 3525

Query: 1623 STSTYFGVRAL 1633
             TS    +RAL
Sbjct: 3526 RTSATLTIRAL 3536



 Score = 67.8 bits (164), Expect = 9e-11
 Identities = 122/500 (24%), Positives = 189/500 (37%), Gaps = 80/500 (16%)

Query: 138  EPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVG 197
            EP+V   A    +    +     ST   C   Q + +       + ++F+S K     VG
Sbjct: 1437 EPKV-VFAKEQPVHREVQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSFSS-KVRMEAVG 1494

Query: 198  HLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILP--G 255
                L +    Q  G+ +  + S      +   HL V   PK V     P+ R +    G
Sbjct: 1495 CTRRLVV----QQAGQAVAGEYSCEAGSQRLSFHLHVA-EPKAVFAKEQPASREVQAEAG 1549

Query: 256  ELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTC 305
               TL+C+V     A + + W KDG +L + + V          L + +A  +DAG Y+C
Sbjct: 1550 TSATLSCEVAQ---AQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSC 1606

Query: 306  QAENGVGSLVSPPISLHIFMAEVQV-----SPAGPILENQ---TVTLVCNTPNEAPSDLR 357
            +A +         +S H+ +AE +V      PA   ++ +   + TL C     A +   
Sbjct: 1607 KAGD-------QRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEV---AQAQTE 1656

Query: 358  YSWYKNHVLLEDAH---------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVV 408
             +WYK+   L  +          +  L +  A +AD G Y CE     G +R   +S  +
Sbjct: 1657 VTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQR---LSFRL 1709

Query: 409  NHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSG-DSDHSPRFSG 467
            +   L P ++     +  LV   H  ++    ATL       +     G +   S R   
Sbjct: 1710 HVAELEPQISERPCRREPLVVKEHEDIILT--ATLATPSAATVTWLKDGVEIRRSKRHET 1767

Query: 468  TSGPNSLRLEIRDLEETDSGEYKCSA-TNSLGNATSTLDFHANAARLLISPAAEVVEGQA 526
             S  ++  L +   +  DS  Y C              +  A   RLL     E+  G  
Sbjct: 1768 ASQGDTHTLTVHGAQVLDSAIYSCRVGAEGQDFPVQVEEVAAKFCRLLEPVCGEL--GGT 1825

Query: 527  VTLSCRSGLSPTPDARFSWYLNGALLH---------EGPGSSLLLPAASSTDAGSYHCRA 577
            VTL+C   LSP   A   W      L          EGP  SL +    + DAG Y C +
Sbjct: 1826 VTLACE--LSPAC-AEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCES 1882

Query: 578  RDGHSASGPSSPAVLTVLYP 597
            RD H++      A LTV  P
Sbjct: 1883 RDDHTS------AQLTVSVP 1896



 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 219/971 (22%), Positives = 342/971 (35%), Gaps = 172/971 (17%)

Query: 172  RLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIH 231
            R Q   + P RS+T    + E  G       ++  S  DH      QL+V+         
Sbjct: 1853 RFQMVAEGPVRSLTVLGLRAEDAGE------YVCESRDDH---TSAQLTVS--------- 1894

Query: 232  LQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ------- 284
                  P+ VK +   S      G   T  C V+   P+  ++ W +DG  LQ       
Sbjct: 1895 -----VPRVVKFMSGLSTVVAEEGGEATFQCVVS---PSDVAVVWFRDGALLQPSEKFAI 1946

Query: 285  TKTGVLH---LPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQT 341
            +++G  H   +      DAG  T +AE G  S  +  +     + + ++ P   + E  +
Sbjct: 1947 SQSGASHSLTISDLVLEDAGQITVEAE-GASSSAALRVREAPVLFKKKLEPQ-TVEERSS 2004

Query: 342  VTLVCNTPNEAPSDLRYSWY-------KNHVLLEDAHSHTLRLHLATRADTGFYFCEVQN 394
            VTL        P +LR++         KN  +  +   H L LH    AD GF+ CE  +
Sbjct: 2005 VTLEVELTRPWP-ELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCETPD 2063

Query: 395  VHGSERSGPVSVVVNHPPLTPVLTAFLETQAGL----VGILHCSVVSEPLATLVLSHGGH 450
                +    ++V +    L   L A    + G     V + H  V          +  G 
Sbjct: 2064 ---DKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQLSHADVDGS------WTRDG- 2113

Query: 451  ILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG--EYKCSATNSLGNATSTLDFHA 508
             L    G + H        GP    L +  L   DSG   +K    ++      T +   
Sbjct: 2114 -LRFQQGPTCHL----AVRGPMHT-LTLSGLRPEDSGLMVFKAEGVHTSARLVVT-ELPV 2166

Query: 509  NAARLLISPAAEVV--EGQAVTLSCRSGLSPTPDARFSWYLNG---------ALLHEGPG 557
            + +R    P  +VV  E + VTL C     P  D R  W  +G         A+  +G  
Sbjct: 2167 SFSR----PLQDVVTTEKEKVTLECELS-RPNVDVR--WLKDGVELRAGKTMAIAAQGAC 2219

Query: 558  SSLLLPAASSTDAGSYHCRARDGHS-ASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGA 616
             SL +      D G Y C A D  S AS        T++Y  R+       ++      A
Sbjct: 2220 RSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIY--RRVLAEDAGEIQFVAENA 2277

Query: 617  GRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCS--------------PR 662
              R  L  RV   P   ++ L +D++          C      +              P+
Sbjct: 2278 ESRAQL--RVKELPVTLVRPL-RDKIAMEKHRGVLECQVSRASAQVRWFKGSQELQPGPK 2334

Query: 663  MKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATF---NGQATVLAIAPSHTL 719
             ++       ++ I +   E+E  Y C+A    G+  TSA F       T++      T+
Sbjct: 2335 YELVSDGLYRKLIISDVHAEDEDTYTCDA----GDVKTSAQFFVEEQSITIVRGLQDVTV 2390

Query: 720  QEGTEANLTCNVSREAAGSPANFSWFRNG-VLWAQGPLE-----TVTLLPVARTDAALYA 773
             E   A   C  S  +   P    W     VL A G +      TV  L + RT + +  
Sbjct: 2391 MEPAPAWFECETSIPSVRPP---KWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTG 2447

Query: 774  CRILTEAGAQLSTPVLLS----VLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLAL 829
                T   ++ S  +++S    VL  P  PK    L          + + D RP      
Sbjct: 2448 PVHFTVGKSRSSARLVVSDIPVVLTRPLEPKTGRELQS-------VVLSCDFRPAPKAVQ 2500

Query: 830  FHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSL 889
            ++ +        P  PS  +F+   E    +L +  L   D+G YRC+A    GS+++S 
Sbjct: 2501 WYKDDT------PLSPSE-KFKMSLEGQMAELRILRLMPADAGVYRCQA----GSAHSST 2549

Query: 890  FFQVRGAWVQVSPSPELQEGQA-----VVLSCQVHTGVPEGTSYRWYRDGQPLQEST--S 942
               V     +V+ +  LQ+ +A        SC++     E     W  +G PL   +   
Sbjct: 2550 EVTVEAR--EVTVTGPLQDAEATEEGWASFSCELS---HEDEEVEWSLNGMPLYNDSFHE 2604

Query: 943  ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL 1002
             + +    TL         A    +++  ++    L V   P  V L  L D      G 
Sbjct: 2605 ISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKP-VVFLKALDDLSAEERGT 2663

Query: 1003 LLCRVD-SDPPAQLRLLHGDRLVASTLQGVG-GPEGSSPRLHVAVAPNTLRLEIHGAMLE 1060
            L  + + SDP A          V     GV  GP      LH A    T  L +H    E
Sbjct: 2664 LALQCEVSDPEAH---------VVWRKDGVQLGPSDKYDFLHTA---GTRGLVVHDVSPE 2711

Query: 1061 DEGVYICEASN 1071
            D G+Y C   +
Sbjct: 2712 DAGLYTCHVGS 2722



 Score = 57.8 bits (138), Expect = 9e-08
 Identities = 79/348 (22%), Positives = 119/348 (34%), Gaps = 82/348 (23%)

Query: 1339 ALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASG 1398
            A + L  P+  V+S  +D      A + C +   P  +++   D + +A  +       G
Sbjct: 9    APRFLTRPKAFVVSVGKD------ATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDG 62

Query: 1399 TGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQVEGARVVAEPG----- 1452
                    +  RL + D+  GD   YVC A+N +G       LQV+     AE       
Sbjct: 63   --------DLYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLL 114

Query: 1453 ----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQA-- 1506
                + V EG+     CR+ G P P      +W  + RRL     P +    +  A A  
Sbjct: 115  RPTSIRVREGSEATFRCRVGGSPRPA----VSWSKDGRRLGEPDGPRVRVEELGEASALR 170

Query: 1507 ---------GMYHCLAELPTGAAASAPVML------------------------------ 1527
                     G Y   AE P GAA++A  ++                              
Sbjct: 171  IRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAM 230

Query: 1528 ----RVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPA 1583
                    PP T T    V    G    L C V  EP          +LV   +      
Sbjct: 231  RAEGAPASPPSTGTRTCTVTE--GKHARLSCYVTGEPKPETVWKKDGQLVTEGR------ 282

Query: 1584 EPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
              H+    +     + I   + SD+G Y C+ASN++G   +S    VR
Sbjct: 283  -RHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVR 329



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 54/192 (28%), Positives = 78/192 (40%), Gaps = 24/192 (12%)

Query: 909  GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST----------SATLRFAAITLTQAGAY 958
            G+ V L+C+V TG P+     WY+DG+ +Q             S  L   ++T   +G Y
Sbjct: 6028 GETVKLACRV-TGTPKPV-ISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQY 6085

Query: 959  HCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLL 1018
             C A +     ++L     + V   PR V          G      C ++  P  Q+R  
Sbjct: 6086 MCFAASAAGNCSTLG---KILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWY 6142

Query: 1019 HGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASA 1078
                L+ +   G      S PR  + V      L I  A  ED G+Y CE  N LG A A
Sbjct: 6143 KDGALLTT---GNKFQTLSEPRSGLLV------LVIRAASKEDLGLYECELVNRLGSARA 6193

Query: 1079 SADFDAQAVNVQ 1090
            SA+   Q+  +Q
Sbjct: 6194 SAELRIQSPMLQ 6205



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 55/222 (24%), Positives = 83/222 (37%), Gaps = 26/222 (11%)

Query: 718  TLQEGTEANLTCNVSREAAGSPAN-FSWFRNGVLWAQGPLETVTLLP----------VAR 766
            T + G    L C V+    G+P    SW+++G      P   +   P          +  
Sbjct: 6024 TAELGETVKLACRVT----GTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTG 6079

Query: 767  TDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLAL 826
             D+  Y C   + AG   ST   + V  PP            +G  A F CT++  P   
Sbjct: 6080 VDSGQYMCFAASAAG-NCSTLGKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQ 6138

Query: 827  LALFHGEHLLATSLGPQVPSHGRFQAKAEANS--LKLEVRELGLGDSGSYRCEATNVLGS 884
            +  +    LL T          +FQ  +E  S  L L +R     D G Y CE  N LGS
Sbjct: 6139 IRWYKDGALLTTG--------NKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGS 6190

Query: 885  SNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGT 926
            +  S   +++   +Q       ++  A V   +  T VP+ T
Sbjct: 6191 ARASAELRIQSPMLQAQEQCHREQLVAAVEVTEQETKVPKKT 6232



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 57/198 (28%), Positives = 86/198 (43%), Gaps = 31/198 (15%)

Query: 524  GQAVTLSCRSGLSPTPDARFSWYLNGA--------LLHEGPGSS--LLLPAASSTDAGSY 573
            G+ V L+CR  ++ TP    SWY +G         +L E P  S  L+L + +  D+G Y
Sbjct: 6028 GETVKLACR--VTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQY 6085

Query: 574  HCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPAR 633
             C A    +A   S+   + V  PPR   F  ++   A+    G      C ++  P  +
Sbjct: 6086 MCFAAS--AAGNCSTLGKILVQVPPR---FVNKVR--ASPFVEGEDAQFTCTIEGAPYPQ 6138

Query: 634  LQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASN 693
            ++  +KD  + T+   G    T     PR        LL + I     E+ GLY CE  N
Sbjct: 6139 IRW-YKDGALLTT---GNKFQTLS--EPRS------GLLVLVIRAASKEDLGLYECELVN 6186

Query: 694  ALGNASTSATFNGQATVL 711
             LG+A  SA    Q+ +L
Sbjct: 6187 RLGSARASAELRIQSPML 6204



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 49/182 (26%), Positives = 72/182 (39%), Gaps = 23/182 (12%)

Query: 1096 TVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ-RLDAHSIP-----------LPNVTVRD 1143
            T   G+ V L C V  T   +   +WY+DG+  ++D H I            L ++T  D
Sbjct: 6024 TAELGETVKLACRV--TGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVD 6081

Query: 1144 ATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQ 1202
            +  Y C      G    L + +   V   PR +          G+ A   CT++  P  Q
Sbjct: 6082 SGQYMCFAASAAGNCSTLGKIL---VQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQ 6138

Query: 1203 LALSHAGRLLASST---AASVPNT--LRLELRGPQPRDEGFYSCSARSPLGQANTSLELR 1257
            +     G LL +       S P +  L L +R     D G Y C   + LG A  S ELR
Sbjct: 6139 IRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELR 6198

Query: 1258 LE 1259
            ++
Sbjct: 6199 IQ 6200



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 49/186 (26%), Positives = 73/186 (39%), Gaps = 22/186 (11%)

Query: 340  QTVTLVCNTPNEAPSDLRYSWYKN---------HVLLEDAH-SHTLRLHLATRADTGFYF 389
            +TV L C         +  SWYK+         H+L+ED   S  L L   T  D+G Y 
Sbjct: 6029 ETVKLACRVTGTPKPVI--SWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYM 6086

Query: 390  CEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGG 449
            C   +  G+  S    ++V  PP             G      C++   P   +     G
Sbjct: 6087 CFAASAAGN-CSTLGKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDG 6145

Query: 450  HILASTSGDSDHSPRFSGTSGPNS--LRLEIRDLEETDSGEYKCSATNSLGNATSTLDFH 507
             +L  T+G+     +F   S P S  L L IR   + D G Y+C   N LG+A ++ +  
Sbjct: 6146 ALL--TTGN-----KFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELR 6198

Query: 508  ANAARL 513
              +  L
Sbjct: 6199 IQSPML 6204



 Score = 40.0 bits (92), Expect = 0.019
 Identities = 88/430 (20%), Positives = 139/430 (32%), Gaps = 101/430 (23%)

Query: 639  KDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEE-------------- 684
            +++ V    P    C   G   P ++  K   LL  + H  + E++              
Sbjct: 5133 QNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPA 5192

Query: 685  --GLYLCEASNALGNASTSATFNGQAT-----VLAIAP------------SHTLQEGTEA 725
              G+Y C A N++G +ST A      T       A A             S   QEGTE+
Sbjct: 5193 DMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTES 5252

Query: 726  NLT----------------------CNVSREAAGSPA-NFSWFRNGV---------LWAQ 753
                                          +  G PA    WF++G          +  +
Sbjct: 5253 TTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDK 5312

Query: 754  GPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQ---- 809
              L T+ ++ V R D+  YA  I    GA  S+  LL  +  PD P+     D+ +    
Sbjct: 5313 KILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLL--VRGPDEPEEKPASDVHEQLVP 5370

Query: 810  --------------GHMALFICTVDSRPLALLALFHGEHLLATS-LGPQVPSHGRFQAKA 854
                          G    F   V+ RP+  +     E       +GP  P    +   +
Sbjct: 5371 PRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPG---YTVAS 5427

Query: 855  EANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVL 914
             A    L + ++G    G+Y C A+N  G +  S    V G      P  E QE     L
Sbjct: 5428 SAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGL-----PKVEEQEKVKEAL 5482

Query: 915  SCQVHTGVPEGTSYRWYR-------DGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGS 967
                  G  +  S +           GQ  +E  +A      ++L + G      +    
Sbjct: 5483 ISTFLQGTTQAISAQGLETASFADLGGQRKEEPLAAKEALGHLSLAEVGTEEFLQKLTSQ 5542

Query: 968  ATTSLAAPIS 977
             T  ++A I+
Sbjct: 5543 ITEMVSAKIT 5552



 Score = 40.0 bits (92), Expect = 0.019
 Identities = 42/188 (22%), Positives = 70/188 (37%), Gaps = 27/188 (14%)

Query: 1458 GAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVP----------TLAFTHVARAQAG 1507
            G  + L+CR+ G P PV     +W+ + + +  +P             L    +    +G
Sbjct: 6028 GETVKLACRVTGTPKPV----ISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSG 6083

Query: 1508 MYHCLAELPTGAAASAPVMLRVLYPPKTPTMM---VFVEPEGGLRGILDCRVDSEPLASL 1564
             Y C A    G  ++   +L V  PP+    +    FVE E        C ++  P   +
Sbjct: 6084 QYMCFAASAAGNCSTLGKIL-VQVPPRFVNKVRASPFVEGEDAQ---FTCTIEGAPYPQI 6139

Query: 1565 TLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSAST 1624
              +    L+ +       +EP   +L       + I A    D G Y C   N LGSA  
Sbjct: 6140 RWYKDGALLTTGNKFQTLSEPRSGLLV------LVIRAASKEDLGLYECELVNRLGSARA 6193

Query: 1625 STYFGVRA 1632
            S    +++
Sbjct: 6194 SAELRIQS 6201



 Score = 36.2 bits (82), Expect = 0.28
 Identities = 42/191 (21%), Positives = 75/191 (39%), Gaps = 25/191 (13%)

Query: 1274 GAPITVTCADPAAHAPTLYTWYHNGRWLQ--------EGPAASLSFLV--ATRAHAGAYS 1323
            G  + + C       P + +WY +G+ +Q        E P  S + ++   T   +G Y 
Sbjct: 6028 GETVKLACRVTGTPKPVI-SWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYM 6086

Query: 1324 CQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSR--ARSMAVIQCTVDSEPPAELALSH 1381
            C A  A G  S+     ++L       ++  R S       A   CT++  P  ++    
Sbjct: 6087 CFAASAAGNCSTLG---KILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYK 6143

Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD--TYVCTAQNLLGSISTIGR 1439
            DG +L T +   +L+         R+ L + V    + +D   Y C   N LGS      
Sbjct: 6144 DGALLTTGNKFQTLSE-------PRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAE 6196

Query: 1440 LQVEGARVVAE 1450
            L+++   + A+
Sbjct: 6197 LRIQSPMLQAQ 6207



 Score = 34.3 bits (77), Expect = 1.1
 Identities = 74/336 (22%), Positives = 111/336 (33%), Gaps = 73/336 (21%)

Query: 520  EVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP----------GSSLLLPAASSTD 569
            EV +G  V+  C     P P  R  W+ +G LL E            G  L++ A    D
Sbjct: 5136 EVQDGYPVSFDCVVTGQPMPSVR--WFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPAD 5193

Query: 570  AGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRV--- 626
             G Y C A +    S  S+ A L V        + T  D   + +    +G L  R    
Sbjct: 5194 MGVYRCLAENSMGVS--STKAELRV--DLTSTDYDTAADATESSSYFSAQGYLSSREQEG 5249

Query: 627  ------DSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRM---------------KV 665
                  +   P  ++ L   +V   +  +       G  +PR+               ++
Sbjct: 5250 TESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRM 5309

Query: 666  TKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATF-----------NGQATVLAIA 714
            T    L  +EI +   E+ G Y    SNA+G A +SA                     + 
Sbjct: 5310 TDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLV 5369

Query: 715  PSHTLQEGTE------ANLTCNVSREAAGSPANFSWFR----NGVLW-----------AQ 753
            P   L+  T       +++T +V  E    P    W R     GVLW           + 
Sbjct: 5370 PPRMLERFTPKKVKKGSSITFSVKVEGRPVP-TVHWLREEAERGVLWIGPDTPGYTVASS 5428

Query: 754  GPLETVTLLPVARTDAALYACRILTEAGAQLSTPVL 789
                ++ LL V R     Y C     AG  L +  L
Sbjct: 5429 AQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASL 5464



 Score = 33.5 bits (75), Expect = 1.8
 Identities = 74/337 (21%), Positives = 114/337 (33%), Gaps = 79/337 (23%)

Query: 255  GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAA------------WSDAGV 302
            G+ + L C V S   A    +WLKDGV L T     H+ Q               +DAG 
Sbjct: 4912 GDALRLECVVASK--ADVRARWLKDGVEL-TDGRHHHIDQLGDGTCSLLITGLDRADAGC 4968

Query: 303  YTCQAENGVGSLV-SPPISLHIFMAEVQVSPAG-----------------------PILE 338
            YTCQ  N  G +  S  + +    +E + S  G                        + +
Sbjct: 4969 YTCQVSNKFGQVTHSACVVVSGSESEAESSSGGELDDAFRRAARRLHRLFRTKSPAEVSD 5028

Query: 339  NQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRA-----------DTGF 387
             +        P E      +  Y+     ED H   +R    T A            T  
Sbjct: 5029 EELFLSADEGPAEPEEPADWQTYR-----EDEHFICIRFEALTEARQAVTRFQEMFATLG 5083

Query: 388  YFCEVQNVHGSERSGPVSV-------VVNHPPLTPVLTA-----FL------ETQAGLVG 429
               E++ V    R   + +       VV   PL  +LT+     FL      E Q G   
Sbjct: 5084 IGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPV 5143

Query: 430  ILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEY 489
               C V  +P+ ++     G +L     + DH        G +  +L I  +   D G Y
Sbjct: 5144 SFDCVVTGQPMPSVRWFKDGKLLE----EDDHYMINEDQQGGH--QLIITAVVPADMGVY 5197

Query: 490  KCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQA 526
            +C A NS+G +++  +   +        AA+  E  +
Sbjct: 5198 RCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSS 5234



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 30/94 (31%), Positives = 44/94 (46%), Gaps = 21/94 (22%)

Query: 234  VKYAPKGV-KILLSPSGRNILPGELVTLTCQVNSS-YPAVSSIKWLKDGVRLQT------ 285
            V+  P+ V K+  SP     + GE    TC +  + YP    I+W KDG  L T      
Sbjct: 6104 VQVPPRFVNKVRASP----FVEGEDAQFTCTIEGAPYP---QIRWYKDGALLTTGNKFQT 6156

Query: 286  ----KTG--VLHLPQAAWSDAGVYTCQAENGVGS 313
                ++G  VL +  A+  D G+Y C+  N +GS
Sbjct: 6157 LSEPRSGLLVLVIRAASKEDLGLYECELVNRLGS 6190


>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
            RhoGEF isoform b [Homo sapiens]
          Length = 7968

 Score =  119 bits (297), Expect = 3e-26
 Identities = 374/1644 (22%), Positives = 572/1644 (34%), Gaps = 315/1644 (19%)

Query: 100  LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159
            L++ D+ PED+G Y       E      V    V +T+  +       +E+LEG    F 
Sbjct: 2703 LVVHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKT------MEVLEGESCSFE 2756

Query: 160  CSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHM-AMSWQDHGRILRCQ 218
            C   +    +       G+        +S +F+ T  G    L +   +  D G ++   
Sbjct: 2757 CVLSHESASDPAMWTVGGK-----TVGSSSRFQATRQGRKYILVVREAAPSDAGEVV--- 2808

Query: 219  LSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLK 278
             SV      S+  L V+  P    I+     + + PGE V L C+++    A + + WLK
Sbjct: 2809 FSVRG--LTSKASLIVRERP--AAIIKPLEDQWVAPGEDVELRCELSR---AGTPVHWLK 2861

Query: 279  D--GVRLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHI----- 323
            D   +R   K  V        L +  A+  DAG YTC+ E    +      SLH+     
Sbjct: 2862 DRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKST-----ASLHVEEKAN 2916

Query: 324  ----FMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH------ 373
                 +  +QV   G      T    C T + A +    +W K  + L  +  H      
Sbjct: 2917 CFTEELTNLQVEEKG------TAVFTCKTEHPAAT---VTWRKGLLELRASGKHQPSQEG 2967

Query: 374  -TLRLHLAT--RADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGI 430
             TLRL ++   +AD+  Y C++    G  +S    +V             ++ Q G    
Sbjct: 2968 LTLRLTISALEKADSDTYTCDI----GQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSAT 3023

Query: 431  LHCSVVS---EPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
              C +     EP+   +     H  A+   + D  P      G + L L  R L   DSG
Sbjct: 3024 FRCRISPANYEPVHWFLDKTPLH--ANELNEIDAQP-----GGYHVLTL--RQLALKDSG 3074

Query: 488  EYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYL 547
                 A +   +A   +    +     ++ A  + EG+ +TL C +    T D    W  
Sbjct: 3075 TIYFEAGDQRASAALRVTEKPSVFSRELTDAT-ITEGEDLTLVCETS---TCDIPVCWTK 3130

Query: 548  NGALL---------HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
            +G  L         HEG  + LL+  A+  D+G Y C       A G  S +++ V    
Sbjct: 3131 DGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKC------EAGGACSSSIVRV--HA 3182

Query: 599  RQPTFTTRL-DLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCG 657
            R   F   L DL+    GA     L C V S   A ++  + + V+              
Sbjct: 3183 RPVRFQEALKDLEVLEGGA---ATLRC-VLSSVAAPVKWCYGNNVLRP------------ 3226

Query: 658  GCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNG---QATVLAIA 714
                +  + +   +L + + N   ++ G Y C    + G+ +TSAT       A  +   
Sbjct: 3227 --GDKYSLRQEGAMLELVVRNLRPQDSGRYSC----SFGDQTTSATLTVTALPAQFIGKL 3280

Query: 715  PSHTLQEGTEANLTCNVSREAAGSPANFS-WFRNG---VLWAQGPLETVTLLPVARTDAA 770
             +    EG  A L C +S+ A       S   R+G    L   G +  + +  +A  DAA
Sbjct: 3281 RNKEATEGATATLRCELSKAAPVEWRKGSETLRDGDRYCLRQDGAMCELQIRGLAMVDAA 3340

Query: 771  LYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALF 830
             Y+C      G + ++  L     P          +  +G  A   C +     A +   
Sbjct: 3341 EYSC----VCGEERTSASLTIRPMPAHFIGRLRHQESIEGATATLRCELSK--AAPVEWR 3394

Query: 831  HGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLF 890
             G   L            R   + +    +L++  L + D+G Y C    V G   TS  
Sbjct: 3395 KGRESLRDG--------DRHSLRQDGAVCELQICGLAVADAGEYSC----VCGEERTSAT 3442

Query: 891  FQVR---GAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRW------YRDGQPL---Q 938
              V+     + +   + E  EG   +L C++    P      W       RDG      Q
Sbjct: 3443 LTVKALPAKFTEGLRNEEAVEGATAMLWCELSKVAP----VEWRKGPENLRDGDRYILRQ 3498

Query: 939  ESTSATLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP 997
            E T   L+   + +  AG Y C   Q   SAT ++ A          R +      +   
Sbjct: 3499 EGTRCELQICGLAMADAGEYLCVCGQERTSATLTIRA-------LPARFIEDVKNQEARE 3551

Query: 998  GRLGLLLCRVDSDPPAQLR-----LLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRL 1052
            G   +L C ++S  P + R     L  GDR    +L+  G                   L
Sbjct: 3552 GATAVLQCELNSAAPVEWRKGSETLRDGDRY---SLRQDG---------------TKCEL 3593

Query: 1053 EIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG---ATVREGQLVNLTCLV 1109
            +I G  + D G Y C      GQ   SA    +A+ ++   G       EG    L C +
Sbjct: 3594 QIRGLAMADTGEYSC----VCGQERTSAMLTVRALPIKFTEGLRNEEATEGATAVLRCEL 3649

Query: 1110 WTTHPAQLTYTWYQDGQQRL---DAHS---------IPLPNVTVRDATSYRCGVGPPGRA 1157
                P +    W++ G + L   D HS         + +  +   DA  Y C  G    +
Sbjct: 3650 SKMAPVE----WWK-GHETLRDGDRHSLRQDGARCELQIRGLVAEDAGEYLCMCGKERTS 3704

Query: 1158 PRLS-RPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASST 1216
              L+ R +    +   RN       E+  G  A + C +    P +    H    L    
Sbjct: 3705 AMLTVRAMPSKFIEGLRN------EEATEGDTATLWCELSKAAPVEWRKGH--ETLRDGD 3756

Query: 1217 AASV---PNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEA---A 1270
              S+    +   L++RG    D G YSC      GQ  TS  L +  +      +     
Sbjct: 3757 RHSLRQDGSRCELQIRGLAVVDAGEYSCVC----GQERTSATLTVRALPARFIEDVKNQE 3812

Query: 1271 VPEGAPITVTC----ADPAAHAPTLYTWYHNGRW--LQEGPAASLSFLVATRAHAGAYSC 1324
              EGA   + C    A P        T     R+   Q+G    L     + A  G YSC
Sbjct: 3813 AREGATAVLQCELSKAAPVEWRKGSETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSC 3872

Query: 1325 QAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHD 1382
                       R +A   + APQ       +  +A   S A +QC + SEP A       
Sbjct: 3873 VC------GQERTSATLTVRAPQPVFREPLQSLQAEEGSTATLQCEL-SEPTA------- 3918

Query: 1383 GKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQ 1441
              V+ +  G+   A+G    ++      L +QD+   D   Y CT     GS +T   L 
Sbjct: 3919 -TVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTC----GSQATSATLT 3973

Query: 1442 VEGARVVAEPGL---DVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP------ 1492
            V  A V     L   +V EG   +L C L      V        W    L   P      
Sbjct: 3974 VTAAPVRFLRELQHQEVDEGGTAHLCCELSRAGASVE-------WRKGSLQLFPCAKYQM 4026

Query: 1493 -----VPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGG 1547
                    L    V +  AG Y C     TG   S   +   +  PK  T +  +E E G
Sbjct: 4027 VQDGAAAELLVRGVEQEDAGDYTC----DTGHTQSMASLSVRVPRPKFKTRLQSLEQETG 4082

Query: 1548 LRGILDCRV-DSEPLA-------SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVD 1599
                L C++ D+E  A        + LH G +    S  QGA  E  IH           
Sbjct: 4083 DIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRS--QGATRELLIH----------- 4129

Query: 1600 IEALRPSDQGEYICSASNVLGSAS 1623
               L   D GEY C       +AS
Sbjct: 4130 --QLEAKDTGEYACVTGGQKTAAS 4151



 Score =  108 bits (269), Expect = 6e-23
 Identities = 242/1165 (20%), Positives = 397/1165 (34%), Gaps = 237/1165 (20%)

Query: 255  GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYT 304
            G    L+C+V     A + + W KDG +L + + V          L LPQA  +DAG Y+
Sbjct: 1089 GASAMLSCEVAQ---AQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYS 1145

Query: 305  CQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTV---------TLVCNTPNEAPSD 355
            C+A           +S H+ + E    P G   + Q+V         T    +   A   
Sbjct: 1146 CEAG-------GQRVSFHLHITE----PKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQ 1194

Query: 356  LRYSWYKNHVLLEDAHSHTLRLHLATR---------ADTGFYFCEVQNVHGSER---SGP 403
               +WYK+   L  +    + +   TR         AD G Y CE      S +   + P
Sbjct: 1195 TEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEP 1254

Query: 404  VSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP 463
             +V         ++   + T+AG    L C V            G  + +S+        
Sbjct: 1255 KAVFAKE----QLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSS-------- 1302

Query: 464  RFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN--------AARLLI 515
            +    +     +L ++   + D+GEY C A          L FH +        A   L 
Sbjct: 1303 KVRIEAAGCMRQLVVQQAGQADAGEYTCEA------GGQRLSFHLDVSEPKAVFAKEQLA 1356

Query: 516  SPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHE---------GPGSSLLLPAAS 566
                +   G   TLSC    + T     +WY +G  L           G    L++  A 
Sbjct: 1357 HRKVQAEAGAIATLSCEVAQAQT---EVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQAC 1413

Query: 567  STDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRV 626
              D G Y C A  G   S     A   V++   QP            A AG    L C V
Sbjct: 1414 QADTGEYSCEA-GGQRLSFSLDVAEPKVVFAKEQPVHR------EVQAQAGASTTLSCEV 1466

Query: 627  DSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGL 686
                 A+ +++        S  S        GC+ R+ V +A   +            G 
Sbjct: 1467 ---AQAQTEVMWYKDGKKLSFSSKVRMEAV-GCTRRLVVQQAGQAV-----------AGE 1511

Query: 687  YLCEASNA-----LGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPAN 741
            Y CEA +      L  A   A F   A     +     + GT A L+C    E A +   
Sbjct: 1512 YSCEAGSQRLSFHLHVAEPKAVF---AKEQPASREVQAEAGTSATLSC----EVAQAQTE 1564

Query: 742  FSWFRNGV---------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQ-------LS 785
             +W+++G          + A G    + +    + DA  Y+C+    AG Q       ++
Sbjct: 1565 VTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCK----AGDQRLSFHLHVA 1620

Query: 786  TPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVP 845
             P ++     P   ++ A      G  A   C V      +     G+ L ++S      
Sbjct: 1621 EPKVVFAKEQPAHREVQA----EAGASATLSCEVAQAQTEVTWYKDGKKLSSSS------ 1670

Query: 846  SHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSP- 904
               + + +A   + +L V++ G  D+G Y CEA    G    S    V     Q+S  P 
Sbjct: 1671 ---KVRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQRLSFRLHVAELEPQISERPC 1723

Query: 905  -----ELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQES---------TSATLRFAAI 950
                  ++E + ++L+  + T  P   +  W +DG  ++ S          + TL     
Sbjct: 1724 RREPLVVKEHEDIILTATLAT--PSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGA 1781

Query: 951  TLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSD 1010
             +  +  Y C+  A G             V           L++   G LG  +      
Sbjct: 1782 QVLDSAIYSCRVGAEGQ---------DFPVQVEEVAAKFCRLLEPVCGELGGTVTLACEL 1832

Query: 1011 PPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLR-LEIHGAMLEDEGVYICEA 1069
             PA           A  +   G  +    +    VA   +R L + G   ED G Y+CE+
Sbjct: 1833 SPA----------CAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCES 1882

Query: 1070 SNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDG---- 1125
             +    A  +         +         EG      C+V    P+ +   W++DG    
Sbjct: 1883 RDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVV---SPSDVAVVWFRDGALLQ 1939

Query: 1126 -------QQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLT 1178
                    Q   +HS+ + ++ + DA            A   S    L V  AP   +  
Sbjct: 1940 PSEKFAISQSGASHSLTISDLVLEDAGQITV------EAEGASSSAALRVREAPVLFKKK 1993

Query: 1179 YLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPR---- 1234
               ++   + ++ L    +RP  +L      R   ++TA +    + +   G + R    
Sbjct: 1994 LEPQTVEERSSVTLEVELTRPWPEL------RWTRNATALAPGKNVEIHAEGARHRLVLH 2047

Query: 1235 -----DEGFYSCSARSPLGQANTSLELR----LEGVRVILAPEAAVPEGAPITVTCADPA 1285
                 D GF+ C       QA  ++E+R    + G++ + A E         T T     
Sbjct: 2048 NVGFADRGFFGCETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQG-------TATMEVQL 2100

Query: 1286 AHAPTLYTWYHNGRWLQEGPAASLS 1310
            +HA    +W  +G   Q+GP   L+
Sbjct: 2101 SHADVDGSWTRDGLRFQQGPTCHLA 2125



 Score =  107 bits (268), Expect = 8e-23
 Identities = 282/1306 (21%), Positives = 449/1306 (34%), Gaps = 223/1306 (17%)

Query: 441  ATLVLSHGGHILASTSGDSDHSP-----RFSGTSGPNSLRLEIRDLEETDSGEYKCSATN 495
            ATL     G+     S + D  P     RF      +  RL I DL   DSG+Y C A N
Sbjct: 27   ATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARN 86

Query: 496  SLGNATSTLDFHANAAR---------LLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWY 546
            ++G A + +    +A           LL   +  V EG   T  CR G SP P    SW 
Sbjct: 87   AIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRP--AVSWS 144

Query: 547  LNGALLHE-----------GPGSSLLLPAASSTDAGSYHCRAR--------------DGH 581
             +G  L E           G  S+L + AA   D G+Y  RA               D  
Sbjct: 145  KDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSD 204

Query: 582  SASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDR 641
            +A   S P   T             +  + A A     G   C V     ARL       
Sbjct: 205  AADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGE 264

Query: 642  VVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTS 701
                ++    G     G    +      N + ++I      + GLY C ASN +G   +S
Sbjct: 265  PKPETVWKKDGQLVTEGRRHVVYEDAQENFV-LKILFCKQSDRGLYTCTASNLVGQTYSS 323

Query: 702  ATFNGQATVLAI---APSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV-LWA----- 752
                 +   +          ++E   A   C V + +  +    +WF+    LWA     
Sbjct: 324  VLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPSTEA----AWFKEETRLWASAKYG 379

Query: 753  ---QGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQ 809
               +G    +T+  V+  D A+Y C   T  G++    + +        P+ +A   +  
Sbjct: 380  IEEEGTERRLTVRNVSADDDAVYICE--TPEGSRTVAELAVQGNLLRKLPRKTA---VRV 434

Query: 810  GHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869
            G  A+F C   + P+  +     +         +V + GR    AE     L + +  L 
Sbjct: 435  GDTAMF-CVELAVPVGPVHWLRNQE--------EVVAGGRVAISAEGTRHTLTISQCCLE 485

Query: 870  DSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGV------- 922
            D G    +   + G   TS  F      V     P LQ     V+  ++ + V       
Sbjct: 486  DVG----QVAFMAGDCQTSTQF-----CVSAPRKPPLQPPVDPVVKARMESSVILSWSPP 536

Query: 923  PEGT----------------SYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPG 966
            P G                 +Y W R     +    AT       + + G +  +  A  
Sbjct: 537  PHGERPVTIDGYLVEKKKLGTYTWIRCH---EAEWVATPELTVADVAEEGNFQFRVSALN 593

Query: 967  SATTS--LAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVD-SDPPAQLRLLHGDRL 1023
            S   S  L  P ++H+  AP+    T L        G +   VD +   A    L G  L
Sbjct: 594  SFGQSPYLEFPGTVHL--APKLAVRTPLKAVQAVEGGEVTFSVDLTVASAGEWFLDGQAL 651

Query: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFD 1083
             AS++      E    R    +    +   +HGA L+    ++     +  +    A   
Sbjct: 652  KASSVY-----EIHCDRTRHTLTIREVPASLHGAQLK----FVANGIESSIRMEVRA--- 699

Query: 1084 AQAVNVQVWPGATVRE--GQLVNLTCLVWTTHPAQLTYTWYQDG-----------QQRLD 1130
            A  +     P A  RE   +L     L+          TW +DG           Q    
Sbjct: 700  APGLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAG 759

Query: 1131 AHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVL--YAPRNLRLTYLLESHGGQL 1188
               + + +V   DA  Y C      R  R++  +++  L  +  +++  + +    GG  
Sbjct: 760  RRVLLVRDVARDDAGLYEC----VSRGGRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPA 815

Query: 1189 ALVLCTVDSRPPAQ-----LALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSA 1243
                 T ++          + L H+G          V    RL       +DEG YSC  
Sbjct: 816  QFECETSEAHVHVHWYKDGMELGHSGERFLQE---DVGTRHRLVAATVTRQDEGTYSCR- 871

Query: 1244 RSPLGQANTSLELRLEGVRVILAPE------AAVPEGAPITVTCADPAAHAPTLYTWYHN 1297
               +G+ +    LR+   +V+ A E           GA  T++C    A A T  TWY +
Sbjct: 872  ---VGEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSC--EVAQAQTEVTWYKD 926

Query: 1298 GRWLQEGPAASLSFLVATR---------AHAGAYSCQAQDAQGTRSSRPAALQVLYAPQD 1348
            G+ L       +     TR         A AG YSC+A   + +        +V++A +D
Sbjct: 927  GKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFA-KD 985

Query: 1349 AVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNA 1408
             V  S   + A + A + C V ++   E+    DGK L++S  VH  A G       R  
Sbjct: 986  QVAHSEVQAEAGASATLSCEV-AQAQTEVMWYKDGKKLSSSLKVHVEAKG-----CRRRL 1039

Query: 1409 LRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV------AEPGLDVPEGAALN 1462
            +  Q     AGD  Y C A+    S     RL +   +++          +    GA+  
Sbjct: 1040 VVQQAGKTDAGD--YSCEARGQRVSF----RLHITEPKMMFAKEQSVHNEVQAEAGASAM 1093

Query: 1463 LSCRLLGGPGPVGNSTFAWFWNDRRLHAEP---------VPTLAFTHVARAQAGMYHCLA 1513
            LSC +      V      W+ + ++L +              L      +A AG Y C A
Sbjct: 1094 LSCEVAQAQTEV-----TWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEA 1148

Query: 1514 ELPTGAAASAPVMLRVLYP----PKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLG 1569
                         L +  P     K  ++   V+ E G   +L C V ++P   +T +  
Sbjct: 1149 -----GGQRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEV-AQPQTEVTWYKD 1202

Query: 1570 SRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSA 1615
             + ++SS          + +       R+ ++ +  +D GEY C A
Sbjct: 1203 GKKLSSSS--------KVRMEVKGCTRRLVVQQVGKADAGEYSCEA 1240



 Score =  106 bits (264), Expect = 2e-22
 Identities = 312/1484 (21%), Positives = 520/1484 (35%), Gaps = 255/1484 (17%)

Query: 256  ELVTLTCQVNSSYPAVSSIKWLKDGVRL--QTKTGV--------LHLPQAAWSDAGVYTC 305
            E  T  C+V    P+  +  W K+  RL    K G+        L +   +  D  VY C
Sbjct: 348  ESATFLCEVPQ--PSTEAA-WFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYIC 404

Query: 306  QAENGVGSLVSPPISLHI-----------------FMAEVQVSPAGPI--LENQTVTLVC 346
            +   G  ++    +  ++                 F  E+ V P GP+  L NQ   +  
Sbjct: 405  ETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAV-PVGPVHWLRNQEEVVAG 463

Query: 347  NTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSV 406
                 +    R++   +   LED         +A    T   FC       + R  P+  
Sbjct: 464  GRVAISAEGTRHTLTISQCCLEDVGQVAF---MAGDCQTSTQFCV-----SAPRKPPLQ- 514

Query: 407  VVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466
                PP+ PV+ A +E+   L      S    P     ++  G+++      +    R  
Sbjct: 515  ----PPVDPVVKARMESSVIL------SWSPPPHGERPVTIDGYLVEKKKLGTYTWIRCH 564

Query: 467  GTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN---AARLLISP---AAE 520
                  +  L + D+ E  + +++ SA NS G +   L+F      A +L +     A +
Sbjct: 565  EAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPY-LEFPGTVHLAPKLAVRTPLKAVQ 623

Query: 521  VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDG 580
             VEG  VT S    +  T  +   W+L+G  L              ++     HC  R  
Sbjct: 624  AVEGGEVTFS----VDLTVASAGEWFLDGQAL-------------KASSVYEIHCD-RTR 665

Query: 581  HSASGPSSPAVL---TVLYPPRQPTFTTRLDLDAAG--------AGAGRRGLLLCRVDSD 629
            H+ +    PA L    + +       + R+++ AA         A A R   +L R+  +
Sbjct: 666  HTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAARE--VLARLHEE 723

Query: 630  PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLC 689
                 +L   D+  A +    G   + G   P+ +V  +     + + +   ++ GLY C
Sbjct: 724  AQLLAEL--SDQAAAVTWLKDGRTLSPG---PKYEVQASAGRRVLLVRDVARDDAGLYEC 778

Query: 690  EASNALGNASTSATFNGQATVLAIAPSHTLQE---GTEANLTCNVSREAAGSPANFSWFR 746
             +    G  +   +  G A  L    + +  +   G  A   C  S     +  +  W++
Sbjct: 779  VSRG--GRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPAQFECETSE----AHVHVHWYK 832

Query: 747  NGVLWAQ----------GPLETVTLLPVARTDAALYACRILTEA---GAQLSTPVLLSVL 793
            +G+              G    +    V R D   Y+CR+  ++     ++S P ++   
Sbjct: 833  DGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKVVFAK 892

Query: 794  YPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAK 853
                R KL A      G  A   C V      +     G+ L ++S         +   +
Sbjct: 893  EQLARRKLQA----EAGASATLSCEVAQAQTEVTWYKDGKKLSSSS---------KVCME 939

Query: 854  AEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV-----QVSPSP-ELQ 907
            A   + +L V++ G  D+G Y CEA    G    S    V+   V     QV+ S  + +
Sbjct: 940  ATGCTRRLVVQQAGQADAGEYSCEA----GGQRLSFHLDVKEPKVVFAKDQVAHSEVQAE 995

Query: 908  EGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSA---------TLRFAAITLTQAGAY 958
             G +  LSC+V       T   WY+DG+ L  S             L       T AG Y
Sbjct: 996  AGASATLSCEV---AQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDY 1052

Query: 959  HCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLL 1018
             C+A+       S    I+       +  ++   +    G   +L C V           
Sbjct: 1053 SCEAR---GQRVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQTEVTWYK 1109

Query: 1019 HGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA-----SNTL 1073
             G +L             SS ++ + V   T RL +  A   D G Y CEA     S  L
Sbjct: 1110 DGKKL------------SSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSFHL 1157

Query: 1074 GQASASADF-DAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH 1132
                    F   Q+V+ +V   A    G    L+C V      Q   TWY+DG++   + 
Sbjct: 1158 HITEPKGVFAKEQSVHNEVQAEA----GTTAMLSCEV---AQPQTEVTWYKDGKKLSSSS 1210

Query: 1133 SIPL-----------PNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLL 1181
             + +             V   DA  Y C  G  G+       IT       +   +   +
Sbjct: 1211 KVRMEVKGCTRRLVVQQVGKADAGEYSCEAG--GQRVSFQLHITEPKAVFAKEQLVHNEV 1268

Query: 1182 ESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT---LRLELRGPQPRDEGF 1238
             +  G  A + C V ++   ++     G+ L+SS+   +       +L ++     D G 
Sbjct: 1269 RTEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGE 1327

Query: 1239 YSCSARSPLGQANTSLELRLEGVRVILAPE------AAVPEGAPITVTCADPAAHAPTLY 1292
            Y+C A    G    S  L +   + + A E           GA  T++C    A A T  
Sbjct: 1328 YTCEA----GGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSC--EVAQAQTEV 1381

Query: 1293 TWYHNGRWLQEGPAASLSFLVATR---------AHAGAYSCQAQDAQGTRSSRPAALQVL 1343
            TWY +G+ L       +  +  TR         A  G YSC+A   + + S   A  +V+
Sbjct: 1382 TWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVV 1441

Query: 1344 YAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403
            +A +  V    + ++A +   + C V ++   E+    DGK L+ SS V   A G     
Sbjct: 1442 FAKEQPVHREVQ-AQAGASTTLSCEV-AQAQTEVMWYKDGKKLSFSSKVRMEAVG----- 1494

Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNL 1463
              R  +  Q     AG+ +    +Q L   +       V      A   +    G +  L
Sbjct: 1495 CTRRLVVQQAGQAVAGEYSCEAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATL 1554

Query: 1464 SCRLLGGPGPVGNSTFAWFWNDRRLHAEP---------VPTLAFTHVARAQAGMYHCLA- 1513
            SC +      V      W+ + ++L +              L      +A AG Y C A 
Sbjct: 1555 SCEVAQAQTEV-----TWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAG 1609

Query: 1514 --ELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSR 1571
               L      + P   +V++  + P     V+ E G    L C V            G +
Sbjct: 1610 DQRLSFHLHVAEP---KVVFAKEQPAHRE-VQAEAGASATLSCEVAQAQTEVTWYKDGKK 1665

Query: 1572 LVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSA 1615
            L +SS+         + V A     R+ ++    +D GEY C A
Sbjct: 1666 LSSSSK---------VRVEAVGCTRRLVVQQAGQADAGEYSCEA 1700



 Score =  104 bits (260), Expect = 6e-22
 Identities = 291/1322 (22%), Positives = 444/1322 (33%), Gaps = 219/1322 (16%)

Query: 94   EHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEG 153
            E  +  L+++    +D+G Y    E S+      V+      TEE            L  
Sbjct: 2877 EGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEE------------LTN 2924

Query: 154  TEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFN--------SQKFEPTGVGHLETLHMA 205
             +V+   +  + C  E          PA +VT+         S K +P+  G    L ++
Sbjct: 2925 LQVEEKGTAVFTCKTEH---------PAATVTWRKGLLELRASGKHQPSQEGLTLRLTIS 2975

Query: 206  MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVN 265
               +       C +  A  RAQ  +        + V I+      ++  G   T  C+++
Sbjct: 2976 ALEKADSDTYTCDIGQAQSRAQLLVQ------GRRVHIIEDLEDVDVQEGSSATFRCRIS 3029

Query: 266  SSYPAVSSIKWLKDGVRLQTKT-----------GVLHLPQAAWSDAG-VYTCQAENGVGS 313
             +      + W  D   L                VL L Q A  D+G +Y    +    +
Sbjct: 3030 PAN--YEPVHWFLDKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEAGDQRASA 3087

Query: 314  LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLE----- 368
             +       +F  E+  +    I E + +TLVC T   +  D+   W K+   L      
Sbjct: 3088 ALRVTEKPSVFSRELTDAT---ITEGEDLTLVCET---STCDIPVCWTKDGKTLRGSARC 3141

Query: 369  ----DAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQ 424
                + H   L +  AT  D+G Y CE     G   S  +  V   P         LE  
Sbjct: 3142 QLSHEGHRAQLLITGATLQDSGRYKCEA----GGACSSSIVRVHARPVRFQEALKDLEVL 3197

Query: 425  AGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEET 484
             G    L C V+S   A +   +G ++L    GD  +S R  G      L L +R+L   
Sbjct: 3198 EGGAATLRC-VLSSVAAPVKWCYGNNVLRP--GDK-YSLRQEGAM----LELVVRNLRPQ 3249

Query: 485  DSGEYKCSATNSLGNATSTLDFHANAARLLIS-PAAEVVEGQAVTLSCR-SGLSPTPDAR 542
            DSG Y CS  +   +AT T+   A  A+ +      E  EG   TL C  S  +P    +
Sbjct: 3250 DSGRYSCSFGDQTTSATLTVT--ALPAQFIGKLRNKEATEGATATLRCELSKAAPVEWRK 3307

Query: 543  FSWYLNG----ALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
             S  L       L  +G    L +   +  DA  Y C   +  ++      A LT+   P
Sbjct: 3308 GSETLRDGDRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTS------ASLTI--RP 3359

Query: 599  RQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGG 658
                F  RL    +  GA     L C +    P         R    SL  G        
Sbjct: 3360 MPAHFIGRLRHQESIEGA--TATLRCELSKAAPVEW------RKGRESLRDG-------- 3403

Query: 659  CSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAP--- 715
               R  + +   +  ++I    + + G Y C      G   TSAT   +A          
Sbjct: 3404 --DRHSLRQDGAVCELQICGLAVADAGEYSC----VCGEERTSATLTVKALPAKFTEGLR 3457

Query: 716  SHTLQEGTEANLTCNVSR----EAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAAL 771
            +    EG  A L C +S+    E    P N       +L  +G    + +  +A  DA  
Sbjct: 3458 NEEAVEGATAMLWCELSKVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGE 3517

Query: 772  YACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFH 831
            Y C    E  +   T   L   +  D     A     +G  A+  C ++S   A +    
Sbjct: 3518 YLCVCGQERTSATLTIRALPARFIEDVKNQEA----REGATAVLQCELNS--AAPVEWRK 3571

Query: 832  GEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFF 891
            G   L            R+  + +    +L++R L + D+G Y C    V G   TS   
Sbjct: 3572 GSETLRDG--------DRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAML 3619

Query: 892  QVRGAWVQVSP---SPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL---------QE 939
             VR   ++ +    + E  EG   VL C++    P      W++  + L         Q+
Sbjct: 3620 TVRALPIKFTEGLRNEEATEGATAVLRCELSKMAP----VEWWKGHETLRDGDRHSLRQD 3675

Query: 940  STSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGR 999
                 L+   +    AG Y C     G   TS    +    S   + +      +   G 
Sbjct: 3676 GARCELQIRGLVAEDAGEYLCMC---GKERTSAMLTVRAMPS---KFIEGLRNEEATEGD 3729

Query: 1000 LGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAML 1059
               L C +    P + R  H       TL+          R  +    +   L+I G  +
Sbjct: 3730 TATLWCELSKAAPVEWRKGH------ETLR-------DGDRHSLRQDGSRCELQIRGLAV 3776

Query: 1060 EDEGVYIC-----EASNTLGQASASADFDAQAVNVQVWPGAT-VREGQLVNLTCLVWTTH 1113
             D G Y C       S TL   +  A F     N +   GAT V + +L     + W   
Sbjct: 3777 VDAGEYSCVCGQERTSATLTVRALPARFIEDVKNQEAREGATAVLQCELSKAAPVEWRKG 3836

Query: 1114 PAQL----TYTWYQDGQQ-RLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV 1168
               L     Y+  QDG +  L  H +     +V D   Y C  G    +  L+      V
Sbjct: 3837 SETLRGGDRYSLRQDGTRCELQIHGL-----SVADTGEYSCVCGQERTSATLTVRAPQPV 3891

Query: 1169 LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPN----TL 1224
               P        L++  G  A + C + S P A +  S  G L   +     P     T 
Sbjct: 3892 FREP-----LQSLQAEEGSTATLQCEL-SEPTATVVWSKGG-LQLQANGRREPRLQGCTA 3944

Query: 1225 RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPE---AAVPEGAPITVTC 1281
             L L+  Q  D G Y+C+     G   TS  L +    V    E     V EG    + C
Sbjct: 3945 ELVLQDLQREDTGEYTCTC----GSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLCC 4000

Query: 1282 ADPAAHAPTLYTWYHNG---------RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGT 1332
                + A     W             + +Q+G AA L      +  AG Y+C     Q  
Sbjct: 4001 --ELSRAGASVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSM 4058

Query: 1333 RS 1334
             S
Sbjct: 4059 AS 4060



 Score =  103 bits (257), Expect = 1e-21
 Identities = 274/1256 (21%), Positives = 423/1256 (33%), Gaps = 235/1256 (18%)

Query: 274  IKWLKDGVRL--------QTKTGVLHLPQAAW---SDAGVYTCQA-ENGVGSLVSPPISL 321
            + W KDG+ L        Q   G  H   AA     D G Y+C+  E+ V   +      
Sbjct: 828  VHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPK 887

Query: 322  HIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH---------S 372
             +F  E             + TL C     A +    +WYK+   L  +          +
Sbjct: 888  VVFAKEQLARRKLQAEAGASATLSCEV---AQAQTEVTWYKDGKKLSSSSKVCMEATGCT 944

Query: 373  HTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLT----PVLTAFLETQAGLV 428
              L +  A +AD G Y CE     G +R     + V  P +      V  + ++ +AG  
Sbjct: 945  RRLVVQQAGQADAGEYSCEA----GGQRLS-FHLDVKEPKVVFAKDQVAHSEVQAEAGAS 999

Query: 429  GILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGE 488
              L C V       +    G  + +S     +        +     RL ++   +TD+G+
Sbjct: 1000 ATLSCEVAQAQTEVMWYKDGKKLSSSLKVHVE--------AKGCRRRLVVQQAGKTDAGD 1051

Query: 489  YKCSATNSLGNATSTLDFHANAARLLISPAAEVVE------GQAVTLSCRSGLSPTPDAR 542
            Y C A         +   H    +++ +    V        G +  LSC    + T    
Sbjct: 1052 YSCEARGQ----RVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQT---E 1104

Query: 543  FSWYLNGALLH---------EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLT 593
             +WY +G  L          +G    L+LP A   DAG Y C A       G    +   
Sbjct: 1105 VTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEA-------GGQRVSFHL 1157

Query: 594  VLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGC 653
             +  P+      +   +   A AG   +L C V    P      +KD    +S  S    
Sbjct: 1158 HITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQ--PQTEVTWYKDGKKLSS--SSKVR 1213

Query: 654  STCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAI 713
                GC+ R+ V +               + G Y CEA       S          V A 
Sbjct: 1214 MEVKGCTRRLVVQQVGKA-----------DAGEYSCEAGGQ--RVSFQLHITEPKAVFAK 1260

Query: 714  APSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLETVTLLPV 764
                  +  TEA  +  +S E A +    +W+++G          + A G +  + +   
Sbjct: 1261 EQLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQA 1320

Query: 765  ARTDAALYACRILTEAGAQ-------LSTPVLLSVLYPPDRPKLSALLDMGQGHMALFIC 817
             + DA  Y C    EAG Q       +S P  +         K+ A      G +A   C
Sbjct: 1321 GQADAGEYTC----EAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQA----EAGAIATLSC 1372

Query: 818  TVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCE 877
             V      +     G+ L ++S         + + +A   + +L V++    D+G Y CE
Sbjct: 1373 EVAQAQTEVTWYKDGKKLSSSS---------KVRMEAVGCTRRLVVQQACQADTGEYSCE 1423

Query: 878  ATNVLGSSNTSLFFQVRGAWV------QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWY 931
            A    G    S    V    V       V    + Q G +  LSC+V       T   WY
Sbjct: 1424 A----GGQRLSFSLDVAEPKVVFAKEQPVHREVQAQAGASTTLSCEV---AQAQTEVMWY 1476

Query: 932  RDGQPLQESTSATLRFAAITLTQ-----------AGAYHCQAQAPGSATTSLAAPISLHV 980
            +DG+ L  S S+ +R  A+  T+           AG Y C+A   GS   S    ++   
Sbjct: 1477 KDGKKL--SFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCEA---GSQRLSFHLHVAEPK 1531

Query: 981  SYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPR 1040
            +   +    +  +    G    L C V            G +L             SS +
Sbjct: 1532 AVFAKEQPASREVQAEAGTSATLSCEVAQAQTEVTWYKDGKKL------------SSSSK 1579

Query: 1041 LHVAVAPNTLRLEIHGAMLEDEGVYICEASNT-----LGQASASADFDAQAV---NVQVW 1092
            + +     T RL +  A   D G Y C+A +      L  A     F  +      VQ  
Sbjct: 1580 VRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAE 1639

Query: 1093 PGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVR---------- 1142
             GA+        L+C V     AQ   TWY+DG++   +  + +  V             
Sbjct: 1640 AGASA------TLSCEV---AQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQ 1690

Query: 1143 -DATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALV--LCTVDSRP 1199
             DA  Y C  G    + RL     L+   + R  R   L+      + L   L T  +  
Sbjct: 1691 ADAGEYSCEAGGQRLSFRL-HVAELEPQISERPCRREPLVVKEHEDIILTATLATPSAAT 1749

Query: 1200 PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE 1259
               L      R       AS  +T  L + G Q  D   YSC     +G       +++E
Sbjct: 1750 VTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCR----VGAEGQDFPVQVE 1805

Query: 1260 GVRV----ILAPEAAVPEGAPITVTCADPAAHAPTLY----TWYHNGRWLQ---EGPAAS 1308
             V      +L P      G  +T+ C    A A  ++    T    G+  Q   EGP  S
Sbjct: 1806 EVAAKFCRLLEPVCG-ELGGTVTLACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRS 1864

Query: 1309 LSFLVATRAHAGAYSCQAQD----AQGTRS------------------SRPAALQVLYAP 1346
            L+ L      AG Y C+++D    AQ T S                     A  Q + +P
Sbjct: 1865 LTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVVSP 1924

Query: 1347 QDAVLSSFRDSR----ARSMAVIQCTVD-SEPPAELALSHDGKVLATSSGVHSLAS 1397
             D  +  FRD      +   A+ Q     S   ++L L   G++   + G  S A+
Sbjct: 1925 SDVAVVWFRDGALLQPSEKFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAA 1980



 Score =  102 bits (255), Expect = 2e-21
 Identities = 283/1294 (21%), Positives = 450/1294 (34%), Gaps = 235/1294 (18%)

Query: 59   WYYDYSGQRQVVSHSADPKLVEARFRG--------RTEFMGNPEHRVCNLLLKDLQPEDS 110
            W     G+R V   + D  LVE +  G          E++  PE     L + D+  E  
Sbjct: 533  WSPPPHGERPV---TIDGYLVEKKKLGTYTWIRCHEAEWVATPE-----LTVADVAEEG- 583

Query: 111  GSYNFRFEISEVNRWS-----DVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYV 165
               NF+F +S +N +      +  GT V +  +  V T    V+ +EG EV F+      
Sbjct: 584  ---NFQFRVSALNSFGQSPYLEFPGT-VHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVA 639

Query: 166  CLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLE---TLHMAMSWQDHGRILRCQLSVA 222
               E     W           + Q  + + V  +    T H     +    +   QL   
Sbjct: 640  SAGE-----W---------FLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFV 685

Query: 223  NHRAQSEIHLQVKYAPKGVKILLSPSG--RNILPG--ELVTLTCQVNSSYPAVSSIKWLK 278
             +  +S I ++V+ AP G+     P+   R +L    E   L  +++    AV+   WLK
Sbjct: 686  ANGIESSIRMEVRAAP-GLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVT---WLK 741

Query: 279  DGVRL--------QTKTG--VLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEV 328
            DG  L        Q   G  VL +   A  DAG+Y C +  G  +       L  F+ + 
Sbjct: 742  DGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKD 801

Query: 329  QVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHV---------LLEDAHS-HTLRLH 378
                    +        C T   + + +   WYK+ +         L ED  + H L   
Sbjct: 802  MAGSCVDAVAGGPAQFECET---SEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAA 858

Query: 379  LATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLT----PVLTAFLETQAGLVGILHCS 434
              TR D G Y C V      E S    + V+ P +      +    L+ +AG    L C 
Sbjct: 859  TVTRQDEGTYSCRV-----GEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSCE 913

Query: 435  VVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSAT 494
            V            G  + +S+        +    +   + RL ++   + D+GEY C A 
Sbjct: 914  VAQAQTEVTWYKDGKKLSSSS--------KVCMEATGCTRRLVVQQAGQADAGEYSCEAG 965

Query: 495  NSLGNATSTLDFHANAARLLISPAAEVVE--------GQAVTLSCRSGLSPTPDARFSWY 546
                     L FH +     +  A + V         G + TLSC    + T      WY
Sbjct: 966  GQ------RLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSCEVAQAQT---EVMWY 1016

Query: 547  LNGALLH---------EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYP 597
             +G  L          +G    L++  A  TDAG Y C AR G   S         +++ 
Sbjct: 1017 KDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEAR-GQRVSFRLHITEPKMMFA 1075

Query: 598  PRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLL-HKDRVVATSLPSGGGCSTC 656
              Q         +   A AG   +L C V     A+ ++  +KD    +S    G     
Sbjct: 1076 KEQSVH------NEVQAEAGASAMLSCEV---AQAQTEVTWYKDGKKLSSSSKVG--MEV 1124

Query: 657  GGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPS 716
             GC+ R+ + +A              + G Y CEA       S          V A   S
Sbjct: 1125 KGCTRRLVLPQAGK-----------ADAGEYSCEAGGQ--RVSFHLHITEPKGVFAKEQS 1171

Query: 717  HTLQEGTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLETVTLLPVART 767
               +   EA  T  +S E A      +W+++G          +  +G    + +  V + 
Sbjct: 1172 VHNEVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKA 1231

Query: 768  DAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLD----MGQGHMALFICTVDSRP 823
            DA  Y+C    EAG Q      L +  P        L+        G  A   C V    
Sbjct: 1232 DAGEYSC----EAGGQ-RVSFQLHITEPKAVFAKEQLVHNEVRTEAGASATLSCEVAQAQ 1286

Query: 824  LALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLG 883
              +     G+ L ++S         + + +A     +L V++ G  D+G Y CEA    G
Sbjct: 1287 TEVTWYKDGKKLSSSS---------KVRIEAAGCMRQLVVQQAGQADAGEYTCEA----G 1333

Query: 884  SSNTSLFFQVRGAWVQVSPSP------ELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL 937
                S    V       +         + + G    LSC+V     E T   WY+DG+ L
Sbjct: 1334 GQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQTEVT---WYKDGKKL 1390

Query: 938  QESTSATLRFAAITLTQ-----------AGAYHCQAQAPG-SATTSLAAPISLHVSYAPR 985
              S+S+ +R  A+  T+            G Y C+A     S +  +A P  +     P 
Sbjct: 1391 --SSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVFAKEQPV 1448

Query: 986  HVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAV 1045
            H      +    G    L C V       +    G +L              S ++ +  
Sbjct: 1449 H----REVQAQAGASTTLSCEVAQAQTEVMWYKDGKKL------------SFSSKVRMEA 1492

Query: 1046 APNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNL 1105
               T RL +  A     G Y CEA +           + +AV  +  P +   + +    
Sbjct: 1493 VGCTRRLVVQQAGQAVAGEYSCEAGSQRLSFHLHV-AEPKAVFAKEQPASREVQAEAGTS 1551

Query: 1106 TCLVWTTHPAQLTYTWYQDGQQ-------RLDA----HSIPLPNVTVRDATSYRCGVGPP 1154
              L      AQ   TWY+DG++       R++A      + +      DA  Y C  G  
Sbjct: 1552 ATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQ 1611

Query: 1155 GRAPRL--SRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLL 1212
              +  L  + P  +     P +      +++  G  A + C V ++   ++     G+ L
Sbjct: 1612 RLSFHLHVAEPKVVFAKEQPAHRE----VQAEAGASATLSCEV-AQAQTEVTWYKDGKKL 1666

Query: 1213 ASST---AASVPNTLRLELRGPQPRDEGFYSCSA 1243
            +SS+     +V  T RL ++     D G YSC A
Sbjct: 1667 SSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA 1700



 Score = 94.7 bits (234), Expect = 7e-19
 Identities = 329/1543 (21%), Positives = 511/1543 (33%), Gaps = 276/1543 (17%)

Query: 229  EIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSS-YPAVSSIKWLKDGVRLQTKT 287
            ++  +   A +    LL P+   +  G   T  C+V  S  PAVS   W KDG RL    
Sbjct: 98   QVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVS---WSKDGRRLGEPD 154

Query: 288  G------------VLHLPQAAWSDAGVYTCQAENGVGSLVS----------------PPI 319
            G             L +  A   D G Y  +AEN +G+  +                P  
Sbjct: 155  GPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGT 214

Query: 320  SLHIFMAEVQV---------SPAGP---------ILENQTVTLVCNTPNEAPSDLRYSWY 361
            S    +A +Q          +PA P         + E +   L C    E   +    W 
Sbjct: 215  STAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPET--VWK 272

Query: 362  KN---------HVLLEDAHSH-TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHP 411
            K+         HV+ EDA  +  L++    ++D G Y C   N+ G   S  + VV    
Sbjct: 273  KDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVV--RE 330

Query: 412  PLTPVLTAF--LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTS 469
            P  P       LE +        C V               + AS     +      GT 
Sbjct: 331  PAVPFKKRLQDLEVREKESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEE----GTE 386

Query: 470  GPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTL 529
                 RL +R++   D   Y C          + L    N  R L  P    V      +
Sbjct: 387  R----RLTVRNVSADDDAVYICETPEG-SRTVAELAVQGNLLRKL--PRKTAVRVGDTAM 439

Query: 530  SCRSGLSPTPDARFSWYLNG---------ALLHEGPGSSLLLPAASSTDAGSY-----HC 575
             C     P       W  N          A+  EG   +L +      D G        C
Sbjct: 440  FCVELAVPVGPVH--WLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDC 497

Query: 576  RARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635
            +       S P  P     L PP  P    R++     +             S PP   +
Sbjct: 498  QTSTQFCVSAPRKPP----LQPPVDPVVKARMESSVILSW------------SPPPHGER 541

Query: 636  LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695
             +  D  +      G    T   C     V   P L   ++      EEG +    S AL
Sbjct: 542  PVTIDGYLVEKKKLG--TYTWIRCHEAEWVA-TPELTVADV-----AEEGNFQFRVS-AL 592

Query: 696  GNASTSATFNGQATV-----LAI-APSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRN 747
             +   S       TV     LA+  P   +Q  EG E   + +++  +AG      WF +
Sbjct: 593  NSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVASAGE-----WFLD 647

Query: 748  G-VLWAQGPLE-----TVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPP----D 797
            G  L A    E     T   L +    A+L+  ++   A   + + + + V   P    +
Sbjct: 648  GQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANG-IESSIRMEVRAAPGLTAN 706

Query: 798  RPKLSALLD-MGQGHM-ALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAE 855
            +P  +A  + + + H  A  +  +  +  A+  L  G  L   S GP      +++ +A 
Sbjct: 707  KPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTL---SPGP------KYEVQAS 757

Query: 856  ANSLKLEVRELGLGDSGSYRCEA--------TNVLGSSNTSLFFQVRGAWVQ-VSPSPEL 906
            A    L VR++   D+G Y C +         +V G +   L   + G+ V  V+  P  
Sbjct: 758  AGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLAR-FLHKDMAGSCVDAVAGGPAQ 816

Query: 907  QEGQAVVLSCQVHTGVPEGTSYRWYRDGQP--------LQESTSATLRFAAITLTQ--AG 956
             E +       VH          WY+DG          LQE      R  A T+T+   G
Sbjct: 817  FECETSEAHVHVH----------WYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEG 866

Query: 957  AYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLR 1016
             Y C+    G  +      +S       +       +    G    L C V         
Sbjct: 867  TYSCRV---GEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVTW 923

Query: 1017 LLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQA 1076
               G +L             SS ++ +     T RL +  A   D G Y CEA    G  
Sbjct: 924  YKDGKKL------------SSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEA----GGQ 967

Query: 1077 SASADFDAQAVNV-----QVWPGATVRE-GQLVNLTCLVWTTHPAQLTYTWYQDGQQ--- 1127
              S   D +   V     QV       E G    L+C V     AQ    WY+DG++   
Sbjct: 968  RLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSCEV---AQAQTEVMWYKDGKKLSS 1024

Query: 1128 RLDAH--------SIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY 1179
             L  H         + +      DA  Y C     G+       IT   +   +   +  
Sbjct: 1025 SLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEA--RGQRVSFRLHITEPKMMFAKEQSVHN 1082

Query: 1180 LLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVP---NTLRLELRGPQPRDE 1236
             +++  G  A++ C V ++   ++     G+ L+SS+   +     T RL L      D 
Sbjct: 1083 EVQAEAGASAMLSCEV-AQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADA 1141

Query: 1237 GFYSCSARSPLGQANTSLELRLEGVRVILAPEAA----VPEGAPITVTCADPAAHAPTLY 1292
            G YSC A    G    S  L +   + + A E +    V   A  T   +   A   T  
Sbjct: 1142 GEYSCEA----GGQRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEV 1197

Query: 1293 TWYHNGRWLQEGPAASLSFLVATR---------AHAGAYSCQAQDAQGTRSSRPAALQVL 1343
            TWY +G+ L       +     TR         A AG YSC+A   + +        + +
Sbjct: 1198 TWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEPKAV 1257

Query: 1344 YAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403
            +A +  V +  R + A + A + C V ++   E+    DGK L++SS V   A+G     
Sbjct: 1258 FAKEQLVHNEVR-TEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRIEAAG----- 1310

Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNL 1463
              R  +  Q     AG+ T     Q L   +       V     +A   +    GA   L
Sbjct: 1311 CMRQLVVQQAGQADAGEYTCEAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATL 1370

Query: 1464 SCRLLGGPGPVGNSTFAWFWNDRRLHAEP---------VPTLAFTHVARAQAGMYHCLAE 1514
            SC +      V      W+ + ++L +              L      +A  G Y C A 
Sbjct: 1371 SCEVAQAQTEV-----TWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAG 1425

Query: 1515 LPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVA 1574
                + +      +V++  + P     V+ + G    L C V       +    G +L  
Sbjct: 1426 GQRLSFSLDVAEPKVVFAKEQPVHRE-VQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSF 1484

Query: 1575 SSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASN 1617
            SS+         + + A     R+ ++    +  GEY C A +
Sbjct: 1485 SSK---------VRMEAVGCTRRLVVQQAGQAVAGEYSCEAGS 1518



 Score = 94.7 bits (234), Expect = 7e-19
 Identities = 362/1685 (21%), Positives = 573/1685 (34%), Gaps = 282/1685 (16%)

Query: 78   LVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTE 137
            L+E R  G+ +   + E     L +  L+  DS +Y      ++      V+G  V + E
Sbjct: 2952 LLELRASGKHQ--PSQEGLTLRLTISALEKADSDTYTCDIGQAQSRAQLLVQGRRVHIIE 3009

Query: 138  EPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQW-QGQDPARSVTFNSQKFEPTGV 196
            +         V++ EG+   F C    +       + W   + P  +   N    +P G 
Sbjct: 3010 D------LEDVDVQEGSSATFRCR---ISPANYEPVHWFLDKTPLHANELNEIDAQPGGY 3060

Query: 197  GHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGE 256
             H+ TL   ++ +D G I        + RA + + +  K +    ++    +   I  GE
Sbjct: 3061 -HVLTLRQ-LALKDSGTIY---FEAGDQRASAALRVTEKPSVFSREL----TDATITEGE 3111

Query: 257  LVTLTCQVNSSYPAVSSIKWLKDGVRLQTKT----------GVLHLPQAAWSDAGVYTCQ 306
             +TL C+ ++    V    W KDG  L+               L +  A   D+G Y C+
Sbjct: 3112 DLTLVCETSTCDIPVC---WTKDGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKCE 3168

Query: 307  AENGVGSLV----SPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYK 362
            A     S +    + P+     + +++V      LE    TL C   + A       W  
Sbjct: 3169 AGGACSSSIVRVHARPVRFQEALKDLEV------LEGGAATLRCVLSSVAAP---VKWCY 3219

Query: 363  NHVLLEDAHSHTLR-----LHLATR----ADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413
             + +L     ++LR     L L  R     D+G Y C      G + +     V   P  
Sbjct: 3220 GNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSF----GDQTTSATLTVTALPAQ 3275

Query: 414  TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNS 473
                    E   G    L C +     A +    G   L    GD     R+        
Sbjct: 3276 FIGKLRNKEATEGATATLRCEL--SKAAPVEWRKGSETLRD--GD-----RYCLRQDGAM 3326

Query: 474  LRLEIRDLEETDSGEYKCSATNSLGNATSTL-DFHANAARLLISPAAEVVEGQAVTLSCR 532
              L+IR L   D+ EY C       +A+ T+    A+    L     E +EG   TL C 
Sbjct: 3327 CELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFIGRL--RHQESIEGATATLRCE 3384

Query: 533  SGLSPTPDARFSWYLNGALLHEGPGSSLLLPAA---------SSTDAGSYHCRARDGHSA 583
               +    A   W      L +G   SL    A         +  DAG Y C   +  ++
Sbjct: 3385 LSKA----APVEWRKGRESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSCVCGEERTS 3440

Query: 584  SGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVV 643
                  A LTV   P +  FT  L  + A  GA    +L C +    P         R  
Sbjct: 3441 ------ATLTVKALPAK--FTEGLRNEEAVEGA--TAMLWCELSKVAPVEW------RKG 3484

Query: 644  ATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSAT 703
              +L  G           R  + +      ++I    + + G YLC      G   TSAT
Sbjct: 3485 PENLRDG----------DRYILRQEGTRCELQICGLAMADAGEYLC----VCGQERTSAT 3530

Query: 704  FNGQ---ATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSW------FRNG---VLW 751
               +   A  +    +   +EG  A L C ++     S A   W       R+G    L 
Sbjct: 3531 LTIRALPARFIEDVKNQEAREGATAVLQCELN-----SAAPVEWRKGSETLRDGDRYSLR 3585

Query: 752  AQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGH 811
              G    + +  +A  D   Y+C    E  + + T   L + +        A     +G 
Sbjct: 3586 QDGTKCELQIRGLAMADTGEYSCVCGQERTSAMLTVRALPIKFTEGLRNEEAT----EGA 3641

Query: 812  MALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDS 871
             A+  C +    +A +  + G   L            R   + +    +L++R L   D+
Sbjct: 3642 TAVLRCELSK--MAPVEWWKGHETLRDG--------DRHSLRQDGARCELQIRGLVAEDA 3691

Query: 872  GSYRCEATNVLGSSNTSLFFQVR---GAWVQVSPSPELQEGQAVVLSCQVHTGVPE--GT 926
            G Y C    + G   TS    VR     +++   + E  EG    L C++    P     
Sbjct: 3692 GEYLC----MCGKERTSAMLTVRAMPSKFIEGLRNEEATEGDTATLWCELSKAAPVEWRK 3747

Query: 927  SYRWYRDGQP---LQESTSATLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSY 982
             +   RDG      Q+ +   L+   + +  AG Y C   Q   SAT ++ A        
Sbjct: 3748 GHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTSATLTVRA-------L 3800

Query: 983  APRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLH 1042
              R +      +   G   +L C +    P +       R  + TL+G         R  
Sbjct: 3801 PARFIEDVKNQEAREGATAVLQCELSKAAPVEW------RKGSETLRG-------GDRYS 3847

Query: 1043 VAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQA---VNVQVWPGATVRE 1099
            +        L+IHG  + D G Y C      GQ   SA    +A   V  +        E
Sbjct: 3848 LRQDGTRCELQIHGLSVADTGEYSC----VCGQERTSATLTVRAPQPVFREPLQSLQAEE 3903

Query: 1100 GQLVNLTC--------LVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGV 1151
            G    L C        +VW+    QL     ++ + +     + L ++   D   Y C  
Sbjct: 3904 GSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTC 3963

Query: 1152 GPPGRAPRLSRPITLDVLYAP-RNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAG- 1209
            G    +       TL V  AP R LR     E   G  A + C + SR  A +       
Sbjct: 3964 GSQATS------ATLTVTAAPVRFLRELQHQEVDEGGTAHLCCEL-SRAGASVEWRKGSL 4016

Query: 1210 RLLASSTAASVPNTLRLEL--RGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP 1267
            +L   +    V +    EL  RG +  D G Y+C       Q+  SL +R+   +     
Sbjct: 4017 QLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHT--QSMASLSVRVPRPKFKTRL 4074

Query: 1268 EAAVPEGAPITVTCADPA-AHAPTLYTWYHNGRWLQEGPAASLSFLVATR---------A 1317
            ++   E   I   C   + A +  +  W   G  L  GP   +    ATR          
Sbjct: 4075 QSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEAK 4134

Query: 1318 HAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQ--CTVDSEPPA 1375
              G Y+C       T   + AA   +  P+  ++    D+   +   ++  C V      
Sbjct: 4135 DTGEYACV------TGGQKTAASLRVTEPEVTIVRGLVDAEVTADEDVEFSCEVSRAGAT 4188

Query: 1376 ELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQ-VQDVPAGDDTYVCTAQNLLGSI 1434
             +     G  L  S+ V  +A   G +    + LRL+ V    AG      T    LG+ 
Sbjct: 4189 GVQWCLQGLPL-QSNEVTEVAVRDGRI----HTLRLKGVTPEDAG------TVSFHLGNH 4237

Query: 1435 STIGRLQVEGARV-VAEPGLDV--PEGAALNLSCRLLGGPGPV------GNSTFAWFWND 1485
            ++  +L V    V + EP  DV   EG   +  CRL    G        G    A   ND
Sbjct: 4238 ASSAQLTVRAPEVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMND 4297

Query: 1486 RRLHAEPVPTLAFTHVARAQAG--MYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVE 1543
              +    +  L    V    AG   +H           S+   L+V         +  VE
Sbjct: 4298 ITVEQGTLHLLTLHKVTLEDAGTVSFHV-------GTCSSEAQLKVTAKNTVVRGLENVE 4350

Query: 1544 PEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALR--VDIE 1601
               G   + +C++    +A+ T  L    V +S+        +  V+   N LR  + ++
Sbjct: 4351 ALEGGEALFECQLSQPEVAAHTWLLDDEPVHTSE--------NAEVVFFENGLRHLLLLK 4402

Query: 1602 ALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGL--LLLLLGL 1659
             LRP D     C  + + G   TS +  VR            W L +L  L    +  G 
Sbjct: 4403 NLRPQDS----CRVTFLAGDMVTSAFLTVRG-----------WRLEILEPLKNAAVRAGA 4447

Query: 1660 GACYT 1664
             AC+T
Sbjct: 4448 QACFT 4452



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 282/1247 (22%), Positives = 418/1247 (33%), Gaps = 244/1247 (19%)

Query: 508  ANAARLLISPAAEVVE-GQAVTLSCRSGLSPTPDARFSWYLN------GA---LLHEGPG 557
            + A R L  P A VV  G+  TLSC+   +PTP    SW  +      GA   L  +G  
Sbjct: 7    SGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQV--SWEKDQQPVAAGARFRLAQDGDL 64

Query: 558  SSLLLPAASSTDAGSYHCRARD--GHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAG 615
              L +   +  D+G Y CRAR+  G + +              + P F  R    +    
Sbjct: 65   YRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPT--SIRVR 122

Query: 616  AGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVE 675
             G      CRV   P   +      R +    P G          PR++V +      + 
Sbjct: 123  EGSEATFRCRVGGSPRPAVSWSKDGRRLGE--PDG----------PRVRVEELGEASALR 170

Query: 676  IHNPLLEEEGLYLCEASNALGNASTSA----------TFNGQATVLAIAPSH-------- 717
            I      + G Y   A N LG AS +A          T +   T  A   +H        
Sbjct: 171  IRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAM 230

Query: 718  -----------------TLQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETV- 759
                             T+ EG  A L+C V+ E         W ++G L  +G    V 
Sbjct: 231  RAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETV---WKKDGQLVTEGRRHVVY 287

Query: 760  ---------TLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP--PDRPKLSALLDMG 808
                      +L   ++D  LY C      G Q  + VL+ V  P  P + +L   L++ 
Sbjct: 288  EDAQENFVLKILFCKQSDRGLYTCTASNLVG-QTYSSVLVVVREPAVPFKKRLQD-LEVR 345

Query: 809  QGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGL 868
            +   A F+C V  +P    A F  E  L  S         ++  + E    +L VR +  
Sbjct: 346  EKESATFLCEV-PQPSTEAAWFKEETRLWAS--------AKYGIEEEGTERRLTVRNVSA 396

Query: 869  GDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSY 928
             D   Y CE       S T     V+G  ++  P           + C V   VP G  +
Sbjct: 397  DDDAVYICETPE---GSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFC-VELAVPVGPVH 452

Query: 929  RWYRDGQPL---------QESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLH 979
             W R+ + +          E T  TL  +   L   G     A   G   TS    +S  
Sbjct: 453  -WLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMA---GDCQTSTQFCVS-- 506

Query: 980  VSYAPRHVTLTTLMD-TGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSS 1038
               APR   L   +D     R+   +    S PP      HG+R V  T+ G    +   
Sbjct: 507  ---APRKPPLQPPVDPVVKARMESSVILSWSPPP------HGERPV--TIDGYLVEKKKL 555

Query: 1039 P-----RLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWP 1093
                  R H A    T  L +     E    +   A N+ GQ S   +F      V + P
Sbjct: 556  GTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQ-SPYLEFPG---TVHLAP 611

Query: 1094 GATVR---------EGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSI-------PLP 1137
               VR         EG  V  +  +      +    W+ DG Q L A S+          
Sbjct: 612  KLAVRTPLKAVQAVEGGEVTFSVDLTVASAGE----WFLDG-QALKASSVYEIHCDRTRH 666

Query: 1138 NVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAP-----------------RNLRLTYL 1180
             +T+R+  +   G      A  +   I ++V  AP                 R      L
Sbjct: 667  TLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQL 726

Query: 1181 LESHGGQLALVLCTVDSRP----PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDE 1236
            L     Q A V    D R     P     + AGR +             L +R     D 
Sbjct: 727  LAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRV-------------LLVRDVARDDA 773

Query: 1237 GFYSCSARSPLGQANTSLELRLEGVRVILAPEAA-----VPEGAPITVTCADPAAHAPTL 1291
            G Y C +R        + +L ++G+   L  + A        G P    C    AH    
Sbjct: 774  GLYECVSRG----GRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPAQFECETSEAHVHV- 828

Query: 1292 YTWYHNG--------RWLQE--GPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQ 1341
              WY +G        R+LQE  G    L     TR   G YSC+  +       R +  +
Sbjct: 829  -HWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPK 887

Query: 1342 VLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGH 1401
            V++A +       + + A + A + C V ++   E+    DGK L++SS V   A+G   
Sbjct: 888  VVFAKEQLARRKLQ-AEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVCMEATG--- 942

Query: 1402 VQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAAL 1461
                R  +  Q     AG+ +     Q L   +       V     VA   +    GA+ 
Sbjct: 943  --CTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASA 1000

Query: 1462 NLSCRLLGGPGPVGNSTFAWFWNDRRL------HAEPV---PTLAFTHVARAQAGMYHCL 1512
             LSC +      V      W+ + ++L      H E       L      +  AG Y C 
Sbjct: 1001 TLSCEVAQAQTEV-----MWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCE 1055

Query: 1513 AELPTGAAASAPVMLRVLYP----PKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHL 1568
            A             L +  P     K  ++   V+ E G   +L C V ++    +T + 
Sbjct: 1056 AR-----GQRVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEV-AQAQTEVTWYK 1109

Query: 1569 GSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSA 1615
              + ++SS   G   +     L  P A +        +D GEY C A
Sbjct: 1110 DGKKLSSSSKVGMEVKGCTRRLVLPQAGK--------ADAGEYSCEA 1148



 Score = 81.6 bits (200), Expect = 6e-15
 Identities = 277/1174 (23%), Positives = 409/1174 (34%), Gaps = 187/1174 (15%)

Query: 255  GELVTLTCQVNSSYPAVSSIKW------LKDG----VRLQTKTGVLHLPQAAWSDAGVYT 304
            G    L C+++     V+ ++W      L+DG    +R +     L +   A +DAG Y 
Sbjct: 3464 GATAMLWCELSK----VAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYL 3519

Query: 305  CQA--ENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYK 362
            C    E    +L    +    F+ +V+   A    E  T  L C   + AP +    W K
Sbjct: 3520 CVCGQERTSATLTIRALPAR-FIEDVKNQEAR---EGATAVLQCELNSAAPVE----WRK 3571

Query: 363  NHVLLEDAHSHTLR---------LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413
                L D   ++LR         +     ADTG Y C    V G ER+  +  V   P  
Sbjct: 3572 GSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAMLTVRALPIK 3627

Query: 414  TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSD-HSPRFSGTSGPN 472
                    E   G   +L C +           H       T  D D HS R  G     
Sbjct: 3628 FTEGLRNEEATEGATAVLRCELSKMAPVEWWKGH------ETLRDGDRHSLRQDGAR--- 3678

Query: 473  SLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA-AEVVEGQAVTLSC 531
               L+IR L   D+GEY C       +A  T+   A  ++ +      E  EG   TL C
Sbjct: 3679 -CELQIRGLVAEDAGEYLCMCGKERTSAMLTV--RAMPSKFIEGLRNEEATEGDTATLWC 3735

Query: 532  R-SGLSPTPDARFSWYLNG----ALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGP 586
              S  +P    +    L      +L  +G    L +   +  DAG Y C      ++   
Sbjct: 3736 ELSKAAPVEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTS--- 3792

Query: 587  SSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATS 646
               A LTV   P +  F    D+    A  G   +L C +    P   +           
Sbjct: 3793 ---ATLTVRALPAR--FIE--DVKNQEAREGATAVLQCELSKAAPVEWRK---------- 3835

Query: 647  LPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNG 706
                 G  T  G   R  + +      ++IH   + + G Y C      G   TSAT   
Sbjct: 3836 -----GSETLRG-GDRYSLRQDGTRCELQIHGLSVADTGEYSC----VCGQERTSATLTV 3885

Query: 707  QATVLAIA-PSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRNGV-LWAQGPLET---- 758
            +A       P  +LQ  EG+ A L C +S   A       W + G+ L A G  E     
Sbjct: 3886 RAPQPVFREPLQSLQAEEGSTATLQCELSEPTA----TVVWSKGGLQLQANGRREPRLQG 3941

Query: 759  ----VTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMAL 814
                + L  + R D   Y C      G+Q ++  L     P    +     ++ +G  A 
Sbjct: 3942 CTAELVLQDLQREDTGEYTCT----CGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAH 3997

Query: 815  FICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSY 874
              C + SR  A +    G   L            ++Q   +  + +L VR +   D+G Y
Sbjct: 3998 LCCEL-SRAGASVEWRKGSLQLFPC--------AKYQMVQDGAAAELLVRGVEQEDAGDY 4048

Query: 875  RCEATNVLGSSNTSLFFQV-RGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRD 933
             C+  +    S  SL  +V R  +     S E + G    L CQ+ +    G   +W ++
Sbjct: 4049 TCDTGHT--QSMASLSVRVPRPKFKTRLQSLEQETGDIARLCCQL-SDAESGAVVQWLKE 4105

Query: 934  GQPLQESTSATLRFAAITLTQAGAYHCQAQAPGS---ATTSLAAPISLHVSYAPRHVTLT 990
            G  L       +R    T  +   +  +A+  G     T       SL V+     VT+ 
Sbjct: 4106 GVELHAGPKYEMRSQGAT-RELLIHQLEAKDTGEYACVTGGQKTAASLRVTEP--EVTIV 4162

Query: 991  TLMDTGPGRLGLLLCRVDSDPPAQLRL---LHGDRLVASTLQGVGGPEGSSPRLHVAVAP 1047
                      GL+   V +D   +        G   V   LQG+  P  S+    VAV  
Sbjct: 4163 R---------GLVDAEVTADEDVEFSCEVSRAGATGVQWCLQGL--PLQSNEVTEVAVRD 4211

Query: 1048 NTLR-LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWP---GATVREGQLV 1103
              +  L + G   ED G      S  LG  ++SA    +A  V +        + EGQ  
Sbjct: 4212 GRIHTLRLKGVTPEDAGT----VSFHLGNHASSAQLTVRAPEVTILEPLQDVQLSEGQDA 4267

Query: 1104 NLTCLV---------WTTHPAQLTYTWYQD-GQQRLDAHSIPLPNVTVRDATSYRCGVGP 1153
            +  C +         W      L      D   ++   H + L  VT+ DA +    VG 
Sbjct: 4268 SFQCRLSRASGQEARWALGGVPLQANEMNDITVEQGTLHLLTLHKVTLEDAGTVSFHVGT 4327

Query: 1154 PGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLA 1213
                 +L       V+    N+      E+  G  AL  C +     A          + 
Sbjct: 4328 CSSEAQLKVTAKNTVVRGLENV------EALEGGEALFECQLSQPEVAAHTWLLDDEPVH 4381

Query: 1214 SSTAASV---PNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRV-ILAP 1267
            +S  A V    N LR  L L+  +P+D    SC      G   TS  L + G R+ IL P
Sbjct: 4382 TSENAEVVFFENGLRHLLLLKNLRPQD----SCRVTFLAGDMVTSAFLTVRGWRLEILEP 4437

Query: 1268 --EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQ----------EGPAASLSFLVAT 1315
               AAV  GA    TC    A      +WY NG  +Q          +G   +L    A 
Sbjct: 4438 LKNAAVRAGAQACFTCTLSEAVPVGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSAQ 4497

Query: 1316 RAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDA 1349
              HAG  +   +DA    S+R   L +   P+DA
Sbjct: 4498 PHHAGEVTFACRDA--VASARLTVLGLPDPPEDA 4529



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 299/1338 (22%), Positives = 457/1338 (34%), Gaps = 238/1338 (17%)

Query: 225  RAQSEIHLQVKYAPKGVKILLSP-SGRNILPGELVTLTCQVNSSYPAVSSIKWLKDG--- 280
            +++S   L V   P  +   L P +GR +   + V L+C      PA  +++W KD    
Sbjct: 2455 KSRSSARLVVSDIPVVLTRPLEPKTGREL---QSVVLSCDFR---PAPKAVQWYKDDTPL 2508

Query: 281  -------VRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPA 333
                   + L+ +   L + +   +DAGVY CQA    GS  S   S  + +   +V+  
Sbjct: 2509 SPSEKFKMSLEGQMAELRILRLMPADAGVYRCQA----GSAHS---STEVTVEAREVTVT 2561

Query: 334  GPI-----LENQTVTLVCNTPNEAPSDLRYSWYKN---------HVLLEDAHSHTLRLHL 379
            GP+      E    +  C   +E   D    W  N         H +      HTL L  
Sbjct: 2562 GPLQDAEATEEGWASFSCELSHE---DEEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKS 2618

Query: 380  ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEP 439
              RAD G        V  S R   + V V        L      + G +  L C  VS+P
Sbjct: 2619 IQRADAGIVRASSLKVSTSAR---LEVRVKPVVFLKALDDLSAEERGTLA-LQCE-VSDP 2673

Query: 440  LATLVLSHGGHILA-STSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG 498
             A +V    G  L  S   D  H+   +GT G     L + D+   D+G Y C   +   
Sbjct: 2674 EAHVVWRKDGVQLGPSDKYDFLHT---AGTRG-----LVVHDVSPEDAGLYTCHVGSEET 2725

Query: 499  NATSTL-DFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALL----- 552
             A   + D H    + L     EV+EG++ +  C        D    W + G  +     
Sbjct: 2726 RARVRVHDLHVGITKRL--KTMEVLEGESCSFECVLSHESASDPAM-WTVGGKTVGSSSR 2782

Query: 553  ----HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLD 608
                 +G    L++  A+ +DAG          S  G +S A L V    R+        
Sbjct: 2783 FQATRQGRKYILVVREAAPSDAGEV------VFSVRGLTSKASLIV----RERPAAIIKP 2832

Query: 609  LDAAGAGAGRRGLLLCRVD-SDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTK 667
            L+      G    L C +  +  P       KDR                  S +  V  
Sbjct: 2833 LEDQWVAPGEDVELRCELSRAGTPVHWL---KDRKAIRK-------------SQKYDVVC 2876

Query: 668  APNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANL 727
               +  + I    L++ G Y CE   +   AS             +      ++GT A  
Sbjct: 2877 EGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEELTNLQVEEKGT-AVF 2935

Query: 728  TCNVSREAAGSPANFSWFRNGVL----------WAQGPLETVTLLPVARTDAALYACRIL 777
            TC     A    A  +W R G+L            +G    +T+  + + D+  Y C I 
Sbjct: 2936 TCKTEHPA----ATVTW-RKGLLELRASGKHQPSQEGLTLRLTISALEKADSDTYTCDI- 2989

Query: 778  TEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLA 837
                AQ    +L+          L   +D+ +G  A F C +        A +   H   
Sbjct: 2990 --GQAQSRAQLLVQGRRVHIIEDLED-VDVQEGSSATFRCRISP------ANYEPVHWFL 3040

Query: 838  TSLGPQVPSHGRFQAKAEANS---LKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894
                 + P H     + +A       L +R+L L DSG+   EA    G    S   +V 
Sbjct: 3041 ----DKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEA----GDQRASAALRVT 3092

Query: 895  ---GAWVQVSPSPELQEGQAVVLSCQVHT-GVPEGTSYRWYRDGQPLQ---------EST 941
                 + +      + EG+ + L C+  T  +P      W +DG+ L+         E  
Sbjct: 3093 EKPSVFSRELTDATITEGEDLTLVCETSTCDIP----VCWTKDGKTLRGSARCQLSHEGH 3148

Query: 942  SATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLG 1001
             A L     TL  +G Y C  +A G+ ++S+    +  V +      L  L     G   
Sbjct: 3149 RAQLLITGATLQDSGRYKC--EAGGACSSSIVRVHARPVRFQEALKDLEVL----EGGAA 3202

Query: 1002 LLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061
             L C V S   A ++  +G+ ++    +     EG+            L L +     +D
Sbjct: 3203 TLRC-VLSSVAAPVKWCYGNNVLRPGDKYSLRQEGA-----------MLELVVRNLRPQD 3250

Query: 1062 EGVYICE-----ASNTLGQASASADFDAQAVNVQVWPGATVR-EGQLVNLTCLVWTTHPA 1115
             G Y C       S TL   +  A F  +  N +   GAT     +L     + W     
Sbjct: 3251 SGRYSCSFGDQTTSATLTVTALPAQFIGKLRNKEATEGATATLRCELSKAAPVEWRKGSE 3310

Query: 1116 QL----TYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYA 1171
             L     Y   QDG        + +  + + DA  Y C  G      R S  +T+  + A
Sbjct: 3311 TLRDGDRYCLRQDGAM----CELQIRGLAMVDAAEYSCVCG----EERTSASLTIRPMPA 3362

Query: 1172 PRNLRLTYLLESHGGQLALVLCTVDSRPPAQL-----ALSHAGRLLASSTAASVPNTLRL 1226
                RL +  ES  G  A + C +    P +      +L    R       A       L
Sbjct: 3363 HFIGRLRH-QESIEGATATLRCELSKAAPVEWRKGRESLRDGDRHSLRQDGA----VCEL 3417

Query: 1227 ELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVI----LAPEAAVPEGAPITVTC- 1281
            ++ G    D G YSC      G+  TS  L ++ +       L  E AV EGA   + C 
Sbjct: 3418 QICGLAVADAGEYSCVC----GEERTSATLTVKALPAKFTEGLRNEEAV-EGATAMLWCE 3472

Query: 1282 ---ADPAAHAPTLYTWYHNGRWL--QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSR 1336
                 P              R++  QEG    L       A AG Y C           R
Sbjct: 3473 LSKVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYLCVC------GQER 3526

Query: 1337 PAALQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHDGKVLATSSGVHS 1394
             +A   + A     +   ++  AR  + AV+QC ++S  P E              G  +
Sbjct: 3527 TSATLTIRALPARFIEDVKNQEAREGATAVLQCELNSAAPVE-----------WRKGSET 3575

Query: 1395 LASGTGH-VQVARNALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQVEGARVVAEPG 1452
            L  G  + ++       LQ++ +   D   Y C    + G   T   L V    +    G
Sbjct: 3576 LRDGDRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAMLTVRALPIKFTEG 3631

Query: 1453 L---DVPEGAALNLSCRL 1467
            L   +  EGA   L C L
Sbjct: 3632 LRNEEATEGATAVLRCEL 3649



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 313/1506 (20%), Positives = 499/1506 (33%), Gaps = 280/1506 (18%)

Query: 255  GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYT 304
            G   TL+C+V     A + + W KDG +L   + V          L + QA  + AG Y+
Sbjct: 1457 GASTTLSCEVAQ---AQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYS 1513

Query: 305  CQAENGVGSLVSPPISLHIFMAEVQV-----SPAGPILENQTVTLVCNTPNEAPSDLRYS 359
            C+A        S  +S H+ +AE +       PA   ++ +  T    +   A +    +
Sbjct: 1514 CEAG-------SQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATLSCEVAQAQTEVT 1566

Query: 360  WYKNHVLLEDAH---------SHTLRLHLATRADTGFYFCEVQN------VHGSERSGPV 404
            WYK+   L  +          +  L +  A +AD G Y C+  +      +H +E   P 
Sbjct: 1567 WYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHVAE---PK 1623

Query: 405  SVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPR 464
             V     P    + A    +AG    L C V            G  + +S+        +
Sbjct: 1624 VVFAKEQPAHREVQA----EAGASATLSCEVAQAQTEVTWYKDGKKLSSSS--------K 1671

Query: 465  FSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAA----- 519
                +   + RL ++   + D+GEY C A    G    +   H       IS        
Sbjct: 1672 VRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQRLSFRLHVAELEPQISERPCRREP 1727

Query: 520  -EVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH---------EGPGSSLLLPAASSTD 569
              V E + + L+    L+    A  +W  +G  +          +G   +L +  A   D
Sbjct: 1728 LVVKEHEDIILTAT--LATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLD 1785

Query: 570  AGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSD 629
            +  Y CR      A G   P  +  +          RL L+      G    L C +   
Sbjct: 1786 SAIYSCRV----GAEGQDFPVQVEEVAAK-----FCRL-LEPVCGELGGTVTLACELS-- 1833

Query: 630  PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLC 689
             PA  +++   R   T L  G           R ++     +  + +     E+ G Y+C
Sbjct: 1834 -PACAEVVW--RCGNTQLRVG----------KRFQMVAEGPVRSLTVLGLRAEDAGEYVC 1880

Query: 690  EASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV 749
            E+ +   +A  + +       ++   +   +EG EA   C VS     S     WFR+G 
Sbjct: 1881 ESRDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVVSP----SDVAVVWFRDGA 1936

Query: 750  LWAQGPLETVTLLPVARTDAALYACRILTEAGA------QLSTPVLLSVLYPPDRPKLSA 803
            L    P E   +     + +   +  +L +AG         S+   L V   P   K   
Sbjct: 1937 LLQ--PSEKFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKL 1994

Query: 804  LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
                 +   ++ +    +RP   L        LA   G  V  H      AE    +L +
Sbjct: 1995 EPQTVEERSSVTLEVELTRPWPELRWTRNATALAP--GKNVEIH------AEGARHRLVL 2046

Query: 864  RELGLGDSGSYRCEATNVLGSSNTSLFFQVRGA-WVQVSPSPELQEGQAVVLSCQVHTGV 922
              +G  D G + CE  +    +   L  ++R    V+   + E +E     +  Q+    
Sbjct: 2047 HNVGFADRGFFGCETPD--DKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQLSHAD 2104

Query: 923  PEGTSYRWYRDGQPLQESTSATL--RFAAITLTQAGAYHCQA-----QAPGSATTSLAAP 975
             +G+   W RDG   Q+  +  L  R    TLT +G     +     +A G  T++    
Sbjct: 2105 VDGS---WTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKAEGVHTSARLVV 2161

Query: 976  ISLHVSYA-PRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034
              L VS++ P    +TT  +        L C + S P   +R L           GV   
Sbjct: 2162 TELPVSFSRPLQDVVTTEKEKVT-----LECEL-SRPNVDVRWLK---------DGVELR 2206

Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASA---------------- 1078
             G +  + +A       L I+     D+GVY+C+A +    AS                 
Sbjct: 2207 AGKT--MAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLA 2264

Query: 1079 -----------SADFDAQAVNVQVWPGATVR--------EGQLVNLTCLVWTTHPAQLTY 1119
                       +A+  AQ + V+  P   VR        E     L C V     A    
Sbjct: 2265 EDAGEIQFVAENAESRAQ-LRVKELPVTLVRPLRDKIAMEKHRGVLECQV---SRASAQV 2320

Query: 1120 TWYQDGQQRLDA-----------HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV 1168
             W++  Q+                 + + +V   D  +Y C  G    + +    +    
Sbjct: 2321 RWFKGSQELQPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDAGDVKTSAQFF--VEEQS 2378

Query: 1169 LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLEL 1228
            +   R L+   ++E               RPP         + L   T       + LE 
Sbjct: 2379 ITIVRGLQDVTVMEPAPAWFECETSIPSVRPP---------KWLLGKTVLQAGGNVGLEQ 2429

Query: 1229 RGPQPRDEGFYSCSARS-----PLGQANTSLELRLEGVRVILAPEAAVPEGAPI-TVTCA 1282
             G   R     +CS  +      +G++ +S  L +  + V+L        G  + +V  +
Sbjct: 2430 EGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPLEPKTGRELQSVVLS 2489

Query: 1283 DPAAHAPTLYTWYHNGRWLQ---------EGPAASLSFLVATRAHAGAYSCQAQDAQGTR 1333
                 AP    WY +   L          EG  A L  L    A AG Y CQA  A  + 
Sbjct: 2490 CDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHSST 2549

Query: 1334 SSRPAALQVLYAPQDAVLSSFRDSRA--RSMAVIQCTVDSEPPAELALSHDGKVLATSSG 1391
                 A +V       V    +D+ A     A   C +  E   E+  S +G  L   S 
Sbjct: 2550 EVTVEAREV------TVTGPLQDAEATEEGWASFSCELSHE-DEEVEWSLNGMPLYNDSF 2602

Query: 1392 VHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEP 1451
                  G  H  V ++  R          D  +  A +L   +ST  RL+V    VV   
Sbjct: 2603 HEISHKGRRHTLVLKSIQRA---------DAGIVRASSL--KVSTSARLEVRVKPVVFLK 2651

Query: 1452 GLD---VPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQ--- 1505
             LD     E   L L C +      V        W    +   P     F H A  +   
Sbjct: 2652 ALDDLSAEERGTLALQCEVSDPEAHV-------VWRKDGVQLGPSDKYDFLHTAGTRGLV 2704

Query: 1506 --------AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVD 1557
                    AG+Y C        A      L V    +  TM V          +L     
Sbjct: 2705 VHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHESA 2764

Query: 1558 SEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASN 1617
            S+P A  T  +G + V SS    A  +   ++L         +    PSD GE + S   
Sbjct: 2765 SDP-AMWT--VGGKTVGSSSRFQATRQGRKYILV--------VREAAPSDAGEVVFSVRG 2813

Query: 1618 VLGSAS 1623
            +   AS
Sbjct: 2814 LTSKAS 2819



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 266/1211 (21%), Positives = 410/1211 (33%), Gaps = 218/1211 (18%)

Query: 509  NAARLLISPAAEVV----------EGQAVTLSCRSGLSPTPDARFSWYLNGALLH----- 553
            ++ARL++S    V+          E Q+V LSC     P P A   WY +   L      
Sbjct: 2458 SSARLVVSDIPVVLTRPLEPKTGRELQSVVLSC--DFRPAPKA-VQWYKDDTPLSPSEKF 2514

Query: 554  ----EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDL 609
                EG  + L +      DAG Y C+A   HS++         V    R+ T T  L  
Sbjct: 2515 KMSLEGQMAELRILRLMPADAGVYRCQAGSAHSST--------EVTVEAREVTVTGPLQ- 2565

Query: 610  DAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAP 669
            DA     G                 +L H+D  V  SL    G          +      
Sbjct: 2566 DAEATEEGWASF-----------SCELSHEDEEVEWSL---NGMPLYNDSFHEISHKGRR 2611

Query: 670  NLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTC 729
            + L ++  +    + G+    +     +A           + A+      + GT A L C
Sbjct: 2612 HTLVLK--SIQRADAGIVRASSLKVSTSARLEVRVKPVVFLKALDDLSAEERGTLA-LQC 2668

Query: 730  NVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVART-----------DAALYACRILT 778
             VS       A+  W ++GV    GP +    L  A T           DA LY C + +
Sbjct: 2669 EVS----DPEAHVVWRKDGV--QLGPSDKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGS 2722

Query: 779  EAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLAT 838
            E   +    V +  L+     +L  + ++ +G    F C +     +  A++       T
Sbjct: 2723 E---ETRARVRVHDLHVGITKRLKTM-EVLEGESCSFECVLSHESASDPAMW-------T 2771

Query: 839  SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV 898
              G  V S  RFQA  +     L VRE    D+G        +  +S  SL  + R A +
Sbjct: 2772 VGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGEVVFSVRGL--TSKASLIVRERPAAI 2829

Query: 899  QVSPSPE--LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQ---------ESTSATLRF 947
             + P  +  +  G+ V L C++      GT   W +D + ++         E T A L  
Sbjct: 2830 -IKPLEDQWVAPGEDVELRCELSRA---GTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVI 2885

Query: 948  AAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVT--LTTLMDTGPGRLGLLLC 1005
               +L  AG Y C+ +A  S         SLHV       T  LT L     G   +  C
Sbjct: 2886 RGASLKDAGEYTCEVEASKSTA-------SLHVEEKANCFTEELTNLQVEEKG-TAVFTC 2937

Query: 1006 RVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVY 1065
            + +  P A +    G       L+  G  + S   L       TLRL I      D   Y
Sbjct: 2938 KTE-HPAATVTWRKG----LLELRASGKHQPSQEGL-------TLRLTISALEKADSDTY 2985

Query: 1066 ICEASNTLGQASASADFDAQAVNVQV---WPGATVREGQLVNLTCLVWTTHPAQL-TYTW 1121
             C+    +GQA + A    Q   V +        V+EG      C +    PA      W
Sbjct: 2986 TCD----IGQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSATFRCRI---SPANYEPVHW 3038

Query: 1122 YQDGQ-------QRLDA-----HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVL 1169
            + D           +DA     H + L  + ++D+ +     G      R S  + +   
Sbjct: 3039 FLDKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEAGD----QRASAALRVTEK 3094

Query: 1170 YAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVP---NTLRL 1226
             +  +  LT    + G  L LV  T     P  +  +  G+ L  S    +    +  +L
Sbjct: 3095 PSVFSRELTDATITEGEDLTLVCETSTCDIP--VCWTKDGKTLRGSARCQLSHEGHRAQL 3152

Query: 1227 ELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAA 1286
             + G   +D G Y C A      +   +  R    +  L  +  V EG   T+ C   + 
Sbjct: 3153 LITGATLQDSGRYKCEAGGACSSSIVRVHARPVRFQEAL-KDLEVLEGGAATLRCVLSSV 3211

Query: 1287 HAPTLYTWYHN-------GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAA 1339
             AP  + + +N           QEG    L         +G YSC   D      +  A 
Sbjct: 3212 AAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSFGD-----QTTSAT 3266

Query: 1340 LQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLAS 1397
            L V   P    +   R+  A   + A ++C +    P E              G  +L  
Sbjct: 3267 LTVTALPAQ-FIGKLRNKEATEGATATLRCELSKAAPVE-----------WRKGSETLRD 3314

Query: 1398 GTGHVQVARNAL-RLQVQD---VPAGDDTYVCTAQNLLGSIST-------IGRLQVEGAR 1446
            G  +      A+  LQ++    V A + + VC  +    S++        IGRL+ +   
Sbjct: 3315 GDRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFIGRLRHQ--- 3371

Query: 1447 VVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA----EPVPTLAFTHVA 1502
                   +  EGA   L C  L    PV          D   H+      V  L    +A
Sbjct: 3372 -------ESIEGATATLRCE-LSKAAPVEWRKGRESLRDGDRHSLRQDGAVCELQICGLA 3423

Query: 1503 RAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLA 1562
             A AG Y C+     G   ++  +     P K    +   E   G   +L C +    +A
Sbjct: 3424 VADAGEYSCVC----GEERTSATLTVKALPAKFTEGLRNEEAVEGATAMLWCELSK--VA 3477

Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
             +    G        P+         +        + I  L  +D GEY+C    V G  
Sbjct: 3478 PVEWRKG--------PENLRDGDRYILRQEGTRCELQICGLAMADAGEYLC----VCGQE 3525

Query: 1623 STSTYFGVRAL 1633
             TS    +RAL
Sbjct: 3526 RTSATLTIRAL 3536



 Score = 67.8 bits (164), Expect = 9e-11
 Identities = 122/500 (24%), Positives = 189/500 (37%), Gaps = 80/500 (16%)

Query: 138  EPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVG 197
            EP+V   A    +    +     ST   C   Q + +       + ++F+S K     VG
Sbjct: 1437 EPKV-VFAKEQPVHREVQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSFSS-KVRMEAVG 1494

Query: 198  HLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILP--G 255
                L +    Q  G+ +  + S      +   HL V   PK V     P+ R +    G
Sbjct: 1495 CTRRLVV----QQAGQAVAGEYSCEAGSQRLSFHLHVA-EPKAVFAKEQPASREVQAEAG 1549

Query: 256  ELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTC 305
               TL+C+V     A + + W KDG +L + + V          L + +A  +DAG Y+C
Sbjct: 1550 TSATLSCEVAQ---AQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSC 1606

Query: 306  QAENGVGSLVSPPISLHIFMAEVQV-----SPAGPILENQ---TVTLVCNTPNEAPSDLR 357
            +A +         +S H+ +AE +V      PA   ++ +   + TL C     A +   
Sbjct: 1607 KAGD-------QRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEV---AQAQTE 1656

Query: 358  YSWYKNHVLLEDAH---------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVV 408
             +WYK+   L  +          +  L +  A +AD G Y CE     G +R   +S  +
Sbjct: 1657 VTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQR---LSFRL 1709

Query: 409  NHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSG-DSDHSPRFSG 467
            +   L P ++     +  LV   H  ++    ATL       +     G +   S R   
Sbjct: 1710 HVAELEPQISERPCRREPLVVKEHEDIILT--ATLATPSAATVTWLKDGVEIRRSKRHET 1767

Query: 468  TSGPNSLRLEIRDLEETDSGEYKCSA-TNSLGNATSTLDFHANAARLLISPAAEVVEGQA 526
             S  ++  L +   +  DS  Y C              +  A   RLL     E+  G  
Sbjct: 1768 ASQGDTHTLTVHGAQVLDSAIYSCRVGAEGQDFPVQVEEVAAKFCRLLEPVCGEL--GGT 1825

Query: 527  VTLSCRSGLSPTPDARFSWYLNGALLH---------EGPGSSLLLPAASSTDAGSYHCRA 577
            VTL+C   LSP   A   W      L          EGP  SL +    + DAG Y C +
Sbjct: 1826 VTLACE--LSPAC-AEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCES 1882

Query: 578  RDGHSASGPSSPAVLTVLYP 597
            RD H++      A LTV  P
Sbjct: 1883 RDDHTS------AQLTVSVP 1896



 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 219/971 (22%), Positives = 342/971 (35%), Gaps = 172/971 (17%)

Query: 172  RLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIH 231
            R Q   + P RS+T    + E  G       ++  S  DH      QL+V+         
Sbjct: 1853 RFQMVAEGPVRSLTVLGLRAEDAGE------YVCESRDDH---TSAQLTVS--------- 1894

Query: 232  LQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ------- 284
                  P+ VK +   S      G   T  C V+   P+  ++ W +DG  LQ       
Sbjct: 1895 -----VPRVVKFMSGLSTVVAEEGGEATFQCVVS---PSDVAVVWFRDGALLQPSEKFAI 1946

Query: 285  TKTGVLH---LPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQT 341
            +++G  H   +      DAG  T +AE G  S  +  +     + + ++ P   + E  +
Sbjct: 1947 SQSGASHSLTISDLVLEDAGQITVEAE-GASSSAALRVREAPVLFKKKLEPQ-TVEERSS 2004

Query: 342  VTLVCNTPNEAPSDLRYSWY-------KNHVLLEDAHSHTLRLHLATRADTGFYFCEVQN 394
            VTL        P +LR++         KN  +  +   H L LH    AD GF+ CE  +
Sbjct: 2005 VTLEVELTRPWP-ELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCETPD 2063

Query: 395  VHGSERSGPVSVVVNHPPLTPVLTAFLETQAGL----VGILHCSVVSEPLATLVLSHGGH 450
                +    ++V +    L   L A    + G     V + H  V          +  G 
Sbjct: 2064 ---DKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQLSHADVDGS------WTRDG- 2113

Query: 451  ILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG--EYKCSATNSLGNATSTLDFHA 508
             L    G + H        GP    L +  L   DSG   +K    ++      T +   
Sbjct: 2114 -LRFQQGPTCHL----AVRGPMHT-LTLSGLRPEDSGLMVFKAEGVHTSARLVVT-ELPV 2166

Query: 509  NAARLLISPAAEVV--EGQAVTLSCRSGLSPTPDARFSWYLNG---------ALLHEGPG 557
            + +R    P  +VV  E + VTL C     P  D R  W  +G         A+  +G  
Sbjct: 2167 SFSR----PLQDVVTTEKEKVTLECELS-RPNVDVR--WLKDGVELRAGKTMAIAAQGAC 2219

Query: 558  SSLLLPAASSTDAGSYHCRARDGHS-ASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGA 616
             SL +      D G Y C A D  S AS        T++Y  R+       ++      A
Sbjct: 2220 RSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIY--RRVLAEDAGEIQFVAENA 2277

Query: 617  GRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCS--------------PR 662
              R  L  RV   P   ++ L +D++          C      +              P+
Sbjct: 2278 ESRAQL--RVKELPVTLVRPL-RDKIAMEKHRGVLECQVSRASAQVRWFKGSQELQPGPK 2334

Query: 663  MKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATF---NGQATVLAIAPSHTL 719
             ++       ++ I +   E+E  Y C+A    G+  TSA F       T++      T+
Sbjct: 2335 YELVSDGLYRKLIISDVHAEDEDTYTCDA----GDVKTSAQFFVEEQSITIVRGLQDVTV 2390

Query: 720  QEGTEANLTCNVSREAAGSPANFSWFRNG-VLWAQGPLE-----TVTLLPVARTDAALYA 773
             E   A   C  S  +   P    W     VL A G +      TV  L + RT + +  
Sbjct: 2391 MEPAPAWFECETSIPSVRPP---KWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTG 2447

Query: 774  CRILTEAGAQLSTPVLLS----VLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLAL 829
                T   ++ S  +++S    VL  P  PK    L          + + D RP      
Sbjct: 2448 PVHFTVGKSRSSARLVVSDIPVVLTRPLEPKTGRELQS-------VVLSCDFRPAPKAVQ 2500

Query: 830  FHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSL 889
            ++ +        P  PS  +F+   E    +L +  L   D+G YRC+A    GS+++S 
Sbjct: 2501 WYKDDT------PLSPSE-KFKMSLEGQMAELRILRLMPADAGVYRCQA----GSAHSST 2549

Query: 890  FFQVRGAWVQVSPSPELQEGQA-----VVLSCQVHTGVPEGTSYRWYRDGQPLQEST--S 942
               V     +V+ +  LQ+ +A        SC++     E     W  +G PL   +   
Sbjct: 2550 EVTVEAR--EVTVTGPLQDAEATEEGWASFSCELS---HEDEEVEWSLNGMPLYNDSFHE 2604

Query: 943  ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL 1002
             + +    TL         A    +++  ++    L V   P  V L  L D      G 
Sbjct: 2605 ISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKP-VVFLKALDDLSAEERGT 2663

Query: 1003 LLCRVD-SDPPAQLRLLHGDRLVASTLQGVG-GPEGSSPRLHVAVAPNTLRLEIHGAMLE 1060
            L  + + SDP A          V     GV  GP      LH A    T  L +H    E
Sbjct: 2664 LALQCEVSDPEAH---------VVWRKDGVQLGPSDKYDFLHTA---GTRGLVVHDVSPE 2711

Query: 1061 DEGVYICEASN 1071
            D G+Y C   +
Sbjct: 2712 DAGLYTCHVGS 2722



 Score = 57.8 bits (138), Expect = 9e-08
 Identities = 79/348 (22%), Positives = 119/348 (34%), Gaps = 82/348 (23%)

Query: 1339 ALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASG 1398
            A + L  P+  V+S  +D      A + C +   P  +++   D + +A  +       G
Sbjct: 9    APRFLTRPKAFVVSVGKD------ATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDG 62

Query: 1399 TGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQVEGARVVAEPG----- 1452
                    +  RL + D+  GD   YVC A+N +G       LQV+     AE       
Sbjct: 63   --------DLYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLL 114

Query: 1453 ----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQA-- 1506
                + V EG+     CR+ G P P      +W  + RRL     P +    +  A A  
Sbjct: 115  RPTSIRVREGSEATFRCRVGGSPRPA----VSWSKDGRRLGEPDGPRVRVEELGEASALR 170

Query: 1507 ---------GMYHCLAELPTGAAASAPVML------------------------------ 1527
                     G Y   AE P GAA++A  ++                              
Sbjct: 171  IRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAM 230

Query: 1528 ----RVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPA 1583
                    PP T T    V    G    L C V  EP          +LV   +      
Sbjct: 231  RAEGAPASPPSTGTRTCTVTE--GKHARLSCYVTGEPKPETVWKKDGQLVTEGR------ 282

Query: 1584 EPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
              H+    +     + I   + SD+G Y C+ASN++G   +S    VR
Sbjct: 283  -RHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVR 329



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 54/192 (28%), Positives = 78/192 (40%), Gaps = 24/192 (12%)

Query: 909  GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST----------SATLRFAAITLTQAGAY 958
            G+ V L+C+V TG P+     WY+DG+ +Q             S  L   ++T   +G Y
Sbjct: 6028 GETVKLACRV-TGTPKPV-ISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQY 6085

Query: 959  HCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLL 1018
             C A +     ++L     + V   PR V          G      C ++  P  Q+R  
Sbjct: 6086 MCFAASAAGNCSTLG---KILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWY 6142

Query: 1019 HGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASA 1078
                L+ +   G      S PR  + V      L I  A  ED G+Y CE  N LG A A
Sbjct: 6143 KDGALLTT---GNKFQTLSEPRSGLLV------LVIRAASKEDLGLYECELVNRLGSARA 6193

Query: 1079 SADFDAQAVNVQ 1090
            SA+   Q+  +Q
Sbjct: 6194 SAELRIQSPMLQ 6205



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 57/198 (28%), Positives = 86/198 (43%), Gaps = 31/198 (15%)

Query: 524  GQAVTLSCRSGLSPTPDARFSWYLNGA--------LLHEGPGSS--LLLPAASSTDAGSY 573
            G+ V L+CR  ++ TP    SWY +G         +L E P  S  L+L + +  D+G Y
Sbjct: 6028 GETVKLACR--VTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQY 6085

Query: 574  HCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPAR 633
             C A    +A   S+   + V  PPR   F  ++   A+    G      C ++  P  +
Sbjct: 6086 MCFAAS--AAGNCSTLGKILVQVPPR---FVNKVR--ASPFVEGEDAQFTCTIEGAPYPQ 6138

Query: 634  LQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASN 693
            ++  +KD  + T+   G    T     PR        LL + I     E+ GLY CE  N
Sbjct: 6139 IRW-YKDGALLTT---GNKFQTLS--EPRS------GLLVLVIRAASKEDLGLYECELVN 6186

Query: 694  ALGNASTSATFNGQATVL 711
             LG+A  SA    Q+ +L
Sbjct: 6187 RLGSARASAELRIQSPML 6204



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 96/460 (20%), Positives = 154/460 (33%), Gaps = 82/460 (17%)

Query: 718  TLQEGTEANLTCNVSREAAGSPAN-FSWFRNGVLWAQGPLETVTLLP----------VAR 766
            T + G    L C V+    G+P    SW+++G      P   +   P          +  
Sbjct: 6024 TAELGETVKLACRVT----GTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTG 6079

Query: 767  TDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLAL 826
             D+  Y C   + AG   ST   + V  PP            +G  A F CT++  P   
Sbjct: 6080 VDSGQYMCFAASAAG-NCSTLGKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQ 6138

Query: 827  LALFHGEHLLATSLGPQVPSHGRFQAKAEANS--LKLEVRELGLGDSGSYRCEATNVLGS 884
            +  +    LL T          +FQ  +E  S  L L +R     D G Y CE  N LGS
Sbjct: 6139 IRWYKDGALLTTG--------NKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGS 6190

Query: 885  SNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT 944
            +  S   +++   +Q       ++  A V    +     E TS      G      ++  
Sbjct: 6191 ARASAELRIQSPMLQAQEQCHREQLVAAVEDTTLERADQEVTSVLKRLLGPKAPGPSTGD 6250

Query: 945  LRFAAITLTQAGAYHCQAQAPGSATTSLAAPI--SLHVSYAPRHVTLTTLMDTGPGRLGL 1002
            L          G   C   AP    T    P+  +      P  V    L+  GP     
Sbjct: 6251 L---------TGPGPCPRGAPALQETGSQPPVTGTSEAPAVPPRVP-QPLLHEGP----- 6295

Query: 1003 LLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED- 1061
                 + +P A  R    +  V   ++G   P               L  ++H  ++ + 
Sbjct: 6296 -----EQEPEAIARA--QEWTVPIRMEGAAWP---------GAGTGELLWDVHSHVVRET 6339

Query: 1062 -EGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYT 1120
             +  Y  +A +T    +          +VQ   G T +   ++            Q + T
Sbjct: 6340 TQRTYTYQAIDT--HTARPPSMQVTIEDVQAQTGGTAQFEAIIE--------GDPQPSVT 6389

Query: 1121 WYQDGQQRLDA-----------HSIPLPNVTVRDATSYRC 1149
            WY+D  Q +D+           +S+ L +V  +DA  Y C
Sbjct: 6390 WYKDSVQLVDSTRLSQQQEGTTYSLVLRHVASKDAGVYTC 6429



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 49/182 (26%), Positives = 72/182 (39%), Gaps = 23/182 (12%)

Query: 1096 TVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ-RLDAHSIP-----------LPNVTVRD 1143
            T   G+ V L C V  T   +   +WY+DG+  ++D H I            L ++T  D
Sbjct: 6024 TAELGETVKLACRV--TGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVD 6081

Query: 1144 ATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQ 1202
            +  Y C      G    L + +   V   PR +          G+ A   CT++  P  Q
Sbjct: 6082 SGQYMCFAASAAGNCSTLGKIL---VQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQ 6138

Query: 1203 LALSHAGRLLASST---AASVPNT--LRLELRGPQPRDEGFYSCSARSPLGQANTSLELR 1257
            +     G LL +       S P +  L L +R     D G Y C   + LG A  S ELR
Sbjct: 6139 IRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELR 6198

Query: 1258 LE 1259
            ++
Sbjct: 6199 IQ 6200



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 49/186 (26%), Positives = 73/186 (39%), Gaps = 22/186 (11%)

Query: 340  QTVTLVCNTPNEAPSDLRYSWYKN---------HVLLEDAH-SHTLRLHLATRADTGFYF 389
            +TV L C         +  SWYK+         H+L+ED   S  L L   T  D+G Y 
Sbjct: 6029 ETVKLACRVTGTPKPVI--SWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYM 6086

Query: 390  CEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGG 449
            C   +  G+  S    ++V  PP             G      C++   P   +     G
Sbjct: 6087 CFAASAAGN-CSTLGKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDG 6145

Query: 450  HILASTSGDSDHSPRFSGTSGPNS--LRLEIRDLEETDSGEYKCSATNSLGNATSTLDFH 507
             +L  T+G+     +F   S P S  L L IR   + D G Y+C   N LG+A ++ +  
Sbjct: 6146 ALL--TTGN-----KFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELR 6198

Query: 508  ANAARL 513
              +  L
Sbjct: 6199 IQSPML 6204



 Score = 40.0 bits (92), Expect = 0.019
 Identities = 88/430 (20%), Positives = 139/430 (32%), Gaps = 101/430 (23%)

Query: 639  KDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEE-------------- 684
            +++ V    P    C   G   P ++  K   LL  + H  + E++              
Sbjct: 5133 QNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPA 5192

Query: 685  --GLYLCEASNALGNASTSATFNGQAT-----VLAIAP------------SHTLQEGTEA 725
              G+Y C A N++G +ST A      T       A A             S   QEGTE+
Sbjct: 5193 DMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTES 5252

Query: 726  NLT----------------------CNVSREAAGSPA-NFSWFRNGV---------LWAQ 753
                                          +  G PA    WF++G          +  +
Sbjct: 5253 TTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDK 5312

Query: 754  GPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQ---- 809
              L T+ ++ V R D+  YA  I    GA  S+  LL  +  PD P+     D+ +    
Sbjct: 5313 KILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLL--VRGPDEPEEKPASDVHEQLVP 5370

Query: 810  --------------GHMALFICTVDSRPLALLALFHGEHLLATS-LGPQVPSHGRFQAKA 854
                          G    F   V+ RP+  +     E       +GP  P    +   +
Sbjct: 5371 PRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPG---YTVAS 5427

Query: 855  EANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVL 914
             A    L + ++G    G+Y C A+N  G +  S    V G      P  E QE     L
Sbjct: 5428 SAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGL-----PKVEEQEKVKEAL 5482

Query: 915  SCQVHTGVPEGTSYRWYR-------DGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGS 967
                  G  +  S +           GQ  +E  +A      ++L + G      +    
Sbjct: 5483 ISTFLQGTTQAISAQGLETASFADLGGQRKEEPLAAKEALGHLSLAEVGTEEFLQKLTSQ 5542

Query: 968  ATTSLAAPIS 977
             T  ++A I+
Sbjct: 5543 ITEMVSAKIT 5552



 Score = 40.0 bits (92), Expect = 0.019
 Identities = 42/188 (22%), Positives = 70/188 (37%), Gaps = 27/188 (14%)

Query: 1458 GAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVP----------TLAFTHVARAQAG 1507
            G  + L+CR+ G P PV     +W+ + + +  +P             L    +    +G
Sbjct: 6028 GETVKLACRVTGTPKPV----ISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSG 6083

Query: 1508 MYHCLAELPTGAAASAPVMLRVLYPPKTPTMM---VFVEPEGGLRGILDCRVDSEPLASL 1564
             Y C A    G  ++   +L V  PP+    +    FVE E        C ++  P   +
Sbjct: 6084 QYMCFAASAAGNCSTLGKIL-VQVPPRFVNKVRASPFVEGEDAQ---FTCTIEGAPYPQI 6139

Query: 1565 TLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSAST 1624
              +    L+ +       +EP   +L       + I A    D G Y C   N LGSA  
Sbjct: 6140 RWYKDGALLTTGNKFQTLSEPRSGLLV------LVIRAASKEDLGLYECELVNRLGSARA 6193

Query: 1625 STYFGVRA 1632
            S    +++
Sbjct: 6194 SAELRIQS 6201



 Score = 40.0 bits (92), Expect = 0.019
 Identities = 26/80 (32%), Positives = 39/80 (48%), Gaps = 13/80 (16%)

Query: 248  SGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVL-----------HLPQAA 296
            S   ++ G+ VTL CQV S+ PA  +  W KDG  L++ + VL            +    
Sbjct: 7470 SDETVVLGQSVTLACQV-SAQPAAQAT-WSKDGAPLESSSRVLISATLKNFQLLTILVVV 7527

Query: 297  WSDAGVYTCQAENGVGSLVS 316
              D GVYTC   N +G++ +
Sbjct: 7528 AEDLGVYTCSVSNALGTVTT 7547



 Score = 37.4 bits (85), Expect = 0.13
 Identities = 31/94 (32%), Positives = 46/94 (48%), Gaps = 9/94 (9%)

Query: 1365 IQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGD-DTY 1423
            + C V ++P A+   S DG  L +SS V  L S T      +N   L +  V A D   Y
Sbjct: 7482 LACQVSAQPAAQATWSKDGAPLESSSRV--LISAT-----LKNFQLLTILVVVAEDLGVY 7534

Query: 1424 VCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPE 1457
             C+  N LG+++T G L+ +  R  + P  D+ E
Sbjct: 7535 TCSVSNALGTVTTTGVLR-KAERPSSSPCPDIGE 7567



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 25/76 (32%), Positives = 35/76 (46%), Gaps = 4/76 (5%)

Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLR----LELRGPQPRDEGFYSC 1241
            GQ   + C V ++P AQ   S  G  L SS+   +  TL+    L +      D G Y+C
Sbjct: 7477 GQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLTILVVVAEDLGVYTC 7536

Query: 1242 SARSPLGQANTSLELR 1257
            S  + LG   T+  LR
Sbjct: 7537 SVSNALGTVTTTGVLR 7552



 Score = 36.2 bits (82), Expect = 0.28
 Identities = 42/191 (21%), Positives = 75/191 (39%), Gaps = 25/191 (13%)

Query: 1274 GAPITVTCADPAAHAPTLYTWYHNGRWLQ--------EGPAASLSFLV--ATRAHAGAYS 1323
            G  + + C       P + +WY +G+ +Q        E P  S + ++   T   +G Y 
Sbjct: 6028 GETVKLACRVTGTPKPVI-SWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYM 6086

Query: 1324 CQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSR--ARSMAVIQCTVDSEPPAELALSH 1381
            C A  A G  S+     ++L       ++  R S       A   CT++  P  ++    
Sbjct: 6087 CFAASAAGNCSTLG---KILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYK 6143

Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD--TYVCTAQNLLGSISTIGR 1439
            DG +L T +   +L+         R+ L + V    + +D   Y C   N LGS      
Sbjct: 6144 DGALLTTGNKFQTLSE-------PRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAE 6196

Query: 1440 LQVEGARVVAE 1450
            L+++   + A+
Sbjct: 6197 LRIQSPMLQAQ 6207



 Score = 34.3 bits (77), Expect = 1.1
 Identities = 74/336 (22%), Positives = 111/336 (33%), Gaps = 73/336 (21%)

Query: 520  EVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP----------GSSLLLPAASSTD 569
            EV +G  V+  C     P P  R  W+ +G LL E            G  L++ A    D
Sbjct: 5136 EVQDGYPVSFDCVVTGQPMPSVR--WFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPAD 5193

Query: 570  AGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRV--- 626
             G Y C A +    S  S+ A L V        + T  D   + +    +G L  R    
Sbjct: 5194 MGVYRCLAENSMGVS--STKAELRV--DLTSTDYDTAADATESSSYFSAQGYLSSREQEG 5249

Query: 627  ------DSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRM---------------KV 665
                  +   P  ++ L   +V   +  +       G  +PR+               ++
Sbjct: 5250 TESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRM 5309

Query: 666  TKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATF-----------NGQATVLAIA 714
            T    L  +EI +   E+ G Y    SNA+G A +SA                     + 
Sbjct: 5310 TDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLV 5369

Query: 715  PSHTLQEGTE------ANLTCNVSREAAGSPANFSWFR----NGVLW-----------AQ 753
            P   L+  T       +++T +V  E    P    W R     GVLW           + 
Sbjct: 5370 PPRMLERFTPKKVKKGSSITFSVKVEGRPVP-TVHWLREEAERGVLWIGPDTPGYTVASS 5428

Query: 754  GPLETVTLLPVARTDAALYACRILTEAGAQLSTPVL 789
                ++ LL V R     Y C     AG  L +  L
Sbjct: 5429 AQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASL 5464



 Score = 33.5 bits (75), Expect = 1.8
 Identities = 74/337 (21%), Positives = 114/337 (33%), Gaps = 79/337 (23%)

Query: 255  GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAA------------WSDAGV 302
            G+ + L C V S   A    +WLKDGV L T     H+ Q               +DAG 
Sbjct: 4912 GDALRLECVVASK--ADVRARWLKDGVEL-TDGRHHHIDQLGDGTCSLLITGLDRADAGC 4968

Query: 303  YTCQAENGVGSLV-SPPISLHIFMAEVQVSPAG-----------------------PILE 338
            YTCQ  N  G +  S  + +    +E + S  G                        + +
Sbjct: 4969 YTCQVSNKFGQVTHSACVVVSGSESEAESSSGGELDDAFRRAARRLHRLFRTKSPAEVSD 5028

Query: 339  NQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRA-----------DTGF 387
             +        P E      +  Y+     ED H   +R    T A            T  
Sbjct: 5029 EELFLSADEGPAEPEEPADWQTYR-----EDEHFICIRFEALTEARQAVTRFQEMFATLG 5083

Query: 388  YFCEVQNVHGSERSGPVSV-------VVNHPPLTPVLTA-----FL------ETQAGLVG 429
               E++ V    R   + +       VV   PL  +LT+     FL      E Q G   
Sbjct: 5084 IGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPV 5143

Query: 430  ILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEY 489
               C V  +P+ ++     G +L     + DH        G +  +L I  +   D G Y
Sbjct: 5144 SFDCVVTGQPMPSVRWFKDGKLLE----EDDHYMINEDQQGGH--QLIITAVVPADMGVY 5197

Query: 490  KCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQA 526
            +C A NS+G +++  +   +        AA+  E  +
Sbjct: 5198 RCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSS 5234



 Score = 33.5 bits (75), Expect = 1.8
 Identities = 25/77 (32%), Positives = 33/77 (42%), Gaps = 13/77 (16%)

Query: 1552 LDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASP---NALRVDIEALRPSDQ 1608
            L C+V ++P A  T              GAP E    VL S    N   + I  +   D 
Sbjct: 7482 LACQVSAQPAAQATW----------SKDGAPLESSSRVLISATLKNFQLLTILVVVAEDL 7531

Query: 1609 GEYICSASNVLGSASTS 1625
            G Y CS SN LG+ +T+
Sbjct: 7532 GVYTCSVSNALGTVTTT 7548



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 30/94 (31%), Positives = 44/94 (46%), Gaps = 21/94 (22%)

Query: 234  VKYAPKGV-KILLSPSGRNILPGELVTLTCQVNSS-YPAVSSIKWLKDGVRLQT------ 285
            V+  P+ V K+  SP     + GE    TC +  + YP    I+W KDG  L T      
Sbjct: 6104 VQVPPRFVNKVRASP----FVEGEDAQFTCTIEGAPYP---QIRWYKDGALLTTGNKFQT 6156

Query: 286  ----KTG--VLHLPQAAWSDAGVYTCQAENGVGS 313
                ++G  VL +  A+  D G+Y C+  N +GS
Sbjct: 6157 LSEPRSGLLVLVIRAASKEDLGLYECELVNRLGS 6190



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 20/53 (37%), Positives = 26/53 (49%), Gaps = 10/53 (18%)

Query: 273  SIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTCQAENGVGSLV 315
            S+ W KD V+L   T +          L L   A  DAGVYTC A+N  G ++
Sbjct: 6387 SVTWYKDSVQLVDSTRLSQQQEGTTYSLVLRHVASKDAGVYTCLAQNTGGQVL 6439



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 36/144 (25%), Positives = 55/144 (38%), Gaps = 27/144 (18%)

Query: 681  LEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740
            LE+EG    +   A    S   +++   T L      T+  G    L C VS + A   A
Sbjct: 7436 LEKEGPPRKKPGLASFRLSGLKSWDRAPTFLRELSDETVVLGQSVTLACQVSAQPA---A 7492

Query: 741  NFSWFRNGVLWAQGPLET---------------VTLLPVARTDAALYACRILTEAGAQLS 785
              +W ++G      PLE+               +T+L V   D  +Y C +    G   +
Sbjct: 7493 QATWSKDGA-----PLESSSRVLISATLKNFQLLTILVVVAEDLGVYTCSVSNALGTVTT 7547

Query: 786  TPVLLSVLYPPDRPKLSALLDMGQ 809
            T     VL   +RP  S   D+G+
Sbjct: 7548 T----GVLRKAERPSSSPCPDIGE 7567


>gi|98986445 carcinoembryonic antigen-related cell adhesion molecule
           5 preproprotein [Homo sapiens]
          Length = 702

 Score =  109 bits (272), Expect = 3e-23
 Identities = 150/623 (24%), Positives = 231/623 (37%), Gaps = 114/623 (18%)

Query: 335 PILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH-------SHTLRLHLATRADTGF 387
           P+ +   V   C    +   D  Y W+ N+  L  +        + TL L   TR DT  
Sbjct: 156 PVEDKDAVAFTCEPETQ---DATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTAS 212

Query: 388 YFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF-LETQAGLVGILHCSVVSEPLATLVLS 446
           Y CE QN   + RS  V + V + P  P ++      ++G    L C   S P A     
Sbjct: 213 YKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPA----- 267

Query: 447 HGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNS---LGNAT-S 502
                         +S   +GT   ++  L I ++   +SG Y C A NS   L   T +
Sbjct: 268 -------------QYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVT 314

Query: 503 TLDFHANAARLLISP--AAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP---- 556
           T+  +A   +  I+   +  V +  AV L+C   +  T    + W++N   L   P    
Sbjct: 315 TITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNT---TYLWWVNNQSLPVSPRLQL 371

Query: 557 ---GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAG 613
                +L L + +  D G Y C  ++  S    S P +L VLY P  PT +        G
Sbjct: 372 SNDNRTLTLLSVTRNDVGPYECGIQNKLSVD-HSDPVILNVLYGPDDPTISPSYTYYRPG 430

Query: 614 AGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLR 673
                   L C   S+PPA+   L    +                           +   
Sbjct: 431 VNLS----LSCHAASNPPAQYSWLIDGNI-------------------------QQHTQE 461

Query: 674 VEIHNPLLEEEGLYLCEASN-ALGNASTSA---TFNGQATVLAIAPSHT--LQEGTEANL 727
           + I N   +  GLY C+A+N A G++ T+    T + +    +I+ +++  +++      
Sbjct: 462 LFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAF 521

Query: 728 TCNVSREAAGSPANFSWFRNGVLWAQGPL-------ETVTLLPVARTDAALYACRILTEA 780
           TC    E       + W+ NG      P         T+TL  V R DA  Y C I    
Sbjct: 522 TC----EPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSV 577

Query: 781 GAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSL 840
            A  S PV L VLY PD P                I   DS  L+   L    H   ++ 
Sbjct: 578 SANRSDPVTLDVLYGPDTP---------------IISPPDSSYLSGANLNLSCH---SAS 619

Query: 841 GPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV 900
            P      R     + ++  L + ++   ++G+Y C  +N+    N S+   V+   V  
Sbjct: 620 NPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSI---VKSITVSA 676

Query: 901 S-PSPELQEGQAVVLSCQVHTGV 922
           S  SP L  G  V +   V  GV
Sbjct: 677 SGTSPGLSAGATVGIMIGVLVGV 699



 Score =  105 bits (263), Expect = 3e-22
 Identities = 117/448 (26%), Positives = 182/448 (40%), Gaps = 86/448 (19%)

Query: 758  TVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSAL-LDMGQGHMALFI 816
            T+TL  V R D A Y C       A+ S  V+L+VLY PD P +S L      G      
Sbjct: 199  TLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLS 258

Query: 817  CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRC 876
            C   S P A  + F                +G FQ   +    +L +  + + +SGSY C
Sbjct: 259  CHAASNPPAQYSWF---------------VNGTFQQSTQ----ELFIPNITVNNSGSYTC 299

Query: 877  EATNV-LGSSNT-----SLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRW 930
            +A N   G + T     +++ +    ++  + S  +++  AV L+C+      + T+Y W
Sbjct: 300  QAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEI---QNTTYLW 356

Query: 931  YRDGQPLQES-------TSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYA 983
            + + Q L  S        + TL   ++T    G Y C  Q     +   + P+ L+V Y 
Sbjct: 357  WVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQ--NKLSVDHSDPVILNVLYG 414

Query: 984  PRHVTLT-TLMDTGPGRLGLLLCRVDSDPPAQLR-LLHGDRLVASTLQGVGGPEGSSPRL 1041
            P   T++ +     PG    L C   S+PPAQ   L+ G+                    
Sbjct: 415  PDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGN-------------------- 454

Query: 1042 HVAVAPNTLRLEIHGAMLEDEGVYICEASN--------TLGQASASADFDAQAVNVQVWP 1093
               +  +T  L I     ++ G+Y C+A+N        T+   + SA+    +++     
Sbjct: 455  ---IQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSN--N 509

Query: 1094 GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ-----RLDA----HSIPLPNVTVRDA 1144
               V +   V  TC          TY W+ +GQ      RL       ++ L NVT  DA
Sbjct: 510  SKPVEDKDAVAFTC---EPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDA 566

Query: 1145 TSYRCGVGPPGRAPRLSRPITLDVLYAP 1172
             +Y CG+     A R S P+TLDVLY P
Sbjct: 567  RAYVCGIQNSVSANR-SDPVTLDVLYGP 593



 Score =  103 bits (258), Expect = 1e-21
 Identities = 162/653 (24%), Positives = 234/653 (35%), Gaps = 119/653 (18%)

Query: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA-SNTLGQASASADF 1082
            V  T Q   GP  S   +   + PN   L I   +  D G Y      + L    A+  F
Sbjct: 83   VIGTQQATPGPAYSGREI---IYPNASLL-IQNIIQNDTGFYTLHVIKSDLVNEEATGQF 138

Query: 1083 ----DAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ-----RLDA-- 1131
                +    ++       V +   V  TC   T      TY W+ + Q      RL    
Sbjct: 139  RVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQ---DATYLWWVNNQSLPVSPRLQLSN 195

Query: 1132 --HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESH-GGQL 1188
               ++ L NVT  D  SY+C    P  A R S  + L+VLY P    ++ L  S+  G+ 
Sbjct: 196  GNRTLTLFNVTRNDTASYKCETQNPVSARR-SDSVILNVLYGPDAPTISPLNTSYRSGEN 254

Query: 1189 ALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLG 1248
              + C   S PPAQ +    G    S+    +PN            + G Y+C A +   
Sbjct: 255  LNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNIT--------VNNSGSYTCQAHNSDT 306

Query: 1249 QAN----TSLELRLEGVRVILAPEAAVP--EGAPITVTCADPAAHAPTLYTWYHNGRWLQ 1302
              N    T++ +  E  +  +    + P  +   + +TC     +  T Y W+ N + L 
Sbjct: 307  GLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQN--TTYLWWVNNQSLP 364

Query: 1303 EGPAASLS-------FLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLS-SF 1354
              P   LS        L  TR   G Y C  Q+      S P  L VLY P D  +S S+
Sbjct: 365  VSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSY 424

Query: 1355 RDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQ 1414
               R      + C   S PPA+ +   DG +       H+      ++    + L     
Sbjct: 425  TYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQ-----HTQELFISNITEKNSGL----- 474

Query: 1415 DVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAE---PGLD------VPEGAALNLSC 1465
                    Y C A N   S S   R  V+   V AE   P +       V +  A+  +C
Sbjct: 475  --------YTCQANN---SASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTC 523

Query: 1466 RLLGGPGPVGNSTFAWFWNDRRLHAEP-------VPTLAFTHVARAQAGMYHCLAELPTG 1518
                      N+T+ W+ N + L   P         TL   +V R  A  Y C  +    
Sbjct: 524  E-----PEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVS 578

Query: 1519 AAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQP 1578
            A  S PV L VLY P TP     + P            DS  L+   L+L     ++  P
Sbjct: 579  ANRSDPVTLDVLYGPDTP----IISPP-----------DSSYLSGANLNLSCHSASNPSP 623

Query: 1579 Q------GAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTS 1625
            Q      G P + H  VL         I  + P++ G Y C  SN+    + S
Sbjct: 624  QYSWRINGIP-QQHTQVLF--------IAKITPNNNGTYACFVSNLATGRNNS 667



 Score = 94.7 bits (234), Expect = 7e-19
 Identities = 113/432 (26%), Positives = 173/432 (40%), Gaps = 60/432 (13%)

Query: 225 RAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ 284
           R    + L V Y P    I  SP   +   GE + L+C   S+ PA  S  W  +G   Q
Sbjct: 224 RRSDSVILNVLYGPDAPTI--SPLNTSYRSGENLNLSCHAASNPPAQYS--WFVNGT-FQ 278

Query: 285 TKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAE-----VQVSPAGPILEN 339
             T  L +P    +++G YTCQA N    L    ++     AE     +  + + P+ + 
Sbjct: 279 QSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDE 338

Query: 340 QTVTLVCNTPNEAPSDLRYSWYKNHVLLE-------DAHSHTLRLHLATRADTGFYFCEV 392
             V L C    +   +  Y W+ N+  L           + TL L   TR D G Y C +
Sbjct: 339 DAVALTCEPEIQ---NTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGI 395

Query: 393 QNVHGSERSGPVSVVVNHPPLTPVLT-AFLETQAGLVGILHCSVVSEPLATLVLSHGGHI 451
           QN    + S PV + V + P  P ++ ++   + G+   L C   S P A          
Sbjct: 396 QNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPA---------- 445

Query: 452 LASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSL-GNATSTLDFHANA 510
                    +S    G    ++  L I ++ E +SG Y C A NS  G++ +T+     +
Sbjct: 446 --------QYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVS 497

Query: 511 ARL----LISPAAEVVEGQ-AVTLSCRSGLSPTPDARFSWYLNGALLHEGP-------GS 558
           A L    + S  ++ VE + AV  +C      T    + W++NG  L   P         
Sbjct: 498 AELPKPSISSNNSKPVEDKDAVAFTCEPEAQNT---TYLWWVNGQSLPVSPRLQLSNGNR 554

Query: 559 SLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGR 618
           +L L   +  DA +Y C  ++  SA+  S P  L VLY P  P  +       +GA    
Sbjct: 555 TLTLFNVTRNDARAYVCGIQNSVSAN-RSDPVTLDVLYGPDTPIISPPDSSYLSGANLN- 612

Query: 619 RGLLLCRVDSDP 630
              L C   S+P
Sbjct: 613 ---LSCHSASNP 621



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 102/419 (24%), Positives = 168/419 (40%), Gaps = 66/419 (15%)

Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIAS----PVELLEGTE 155
           L + ++   +SGSY  +   S+    +    T +TV  EP  P I S    PVE  +   
Sbjct: 284 LFIPNITVNNSGSYTCQAHNSDTGL-NRTTVTTITVYAEPPKPFITSNNSNPVE--DEDA 340

Query: 156 VDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRI- 214
           V   C      +Q    L W            S + + +      TL ++++  D G   
Sbjct: 341 VALTCEPE---IQNTTYLWWVNNQSLPV----SPRLQLSNDNRTLTL-LSVTRNDVGPYE 392

Query: 215 --LRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVS 272
             ++ +LSV +      + L V Y P    I  SPS     PG  ++L+C   S+ PA  
Sbjct: 393 CGIQNKLSVDH---SDPVILNVLYGPDDPTI--SPSYTYYRPGVNLSLSCHAASNPPAQY 447

Query: 273 SIKWLKDGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGVG-----SLVSPPISLHIFMAE 327
           S  WL DG  +Q  T  L +      ++G+YTCQA N        ++ +  +S  +    
Sbjct: 448 S--WLIDG-NIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPS 504

Query: 328 VQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH-------SHTLRLHLA 380
           +  + + P+ +   V   C    +   +  Y W+ N   L  +        + TL L   
Sbjct: 505 ISSNNSKPVEDKDAVAFTCEPEAQ---NTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNV 561

Query: 381 TRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPL 440
           TR D   Y C +QN   + RS PV++ V + P TP+++                    P 
Sbjct: 562 TRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--------------------PP 601

Query: 441 ATLVLSHGGHILASTSGDSDHSPRFS----GTSGPNSLRLEIRDLEETDSGEYKCSATN 495
            +  LS G ++  S    S+ SP++S    G    ++  L I  +   ++G Y C  +N
Sbjct: 602 DSSYLS-GANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSN 659



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 113/538 (21%), Positives = 194/538 (36%), Gaps = 82/538 (15%)

Query: 660  SPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG-NASTSATFNGQ--ATVLAIAPS 716
            SPR++++     L   + N    +   Y CE  N +    S S   N         I+P 
Sbjct: 188  SPRLQLSNGNRTLT--LFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPL 245

Query: 717  HT-LQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACR 775
            +T  + G   NL+C+    A+  PA +SWF NG    Q   + + +  +   ++  Y C+
Sbjct: 246  NTSYRSGENLNLSCHA---ASNPPAQYSWFVNGTF--QQSTQELFIPNITVNNSGSYTCQ 300

Query: 776  I-LTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEH 834
               ++ G   +T   ++V   P +P               FI + +S P+        E 
Sbjct: 301  AHNSDTGLNRTTVTTITVYAEPPKP---------------FITSNNSNPV------EDED 339

Query: 835  LLATSLGPQV--------------PSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATN 880
             +A +  P++              P   R Q   +  +L L    +   D G Y C   N
Sbjct: 340  AVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTL--LSVTRNDVGPYECGIQN 397

Query: 881  VLGSSNTS-LFFQVRGAWVQVSPSPE---LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP 936
             L   ++  +   V       + SP     + G  + LSC   +  P    Y W  DG  
Sbjct: 398  KLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPP--AQYSWLIDGN- 454

Query: 937  LQESTSATLRFAAITLTQAGAYHCQA--QAPGSATTSLAAPISLHVSYAPRHVTLTTLMD 994
            +Q+ T   L  + IT   +G Y CQA   A G + T++   I++        ++      
Sbjct: 455  IQQHTQ-ELFISNITEKNSGLYTCQANNSASGHSRTTVKT-ITVSAELPKPSISSNNSKP 512

Query: 995  TGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEI 1054
                      C  ++     L  ++G  L              SPRL ++    TL L  
Sbjct: 513  VEDKDAVAFTCEPEAQNTTYLWWVNGQSLPV------------SPRLQLSNGNRTLTL-- 558

Query: 1055 HGAMLEDEGVYICEASNTL-GQASASADFD---AQAVNVQVWPGATVREGQLVNLTCLVW 1110
                  D   Y+C   N++    S     D        +   P ++   G  +NL+C   
Sbjct: 559  FNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSA 618

Query: 1111 TTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVG--PPGRAPRLSRPITL 1166
            +    Q  Y+W  +G  +     + +  +T  +  +Y C V     GR   + + IT+
Sbjct: 619  SNPSPQ--YSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITV 674


>gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Homo
           sapiens]
          Length = 698

 Score =  108 bits (269), Expect = 6e-23
 Identities = 135/531 (25%), Positives = 217/531 (40%), Gaps = 80/531 (15%)

Query: 5   PKLLLLASFFPAGQA-------SWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITA 57
           P++LLL    P   A       S+ +   + V   +G C+++ C  S+P D    D  TA
Sbjct: 11  PEMLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDGW--DESTA 68

Query: 58  IWYYDYSGQRQV-----VSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGS 112
            + Y + G+        V+ +   + VE   R R +  G+P    C+L+++D Q ED   
Sbjct: 69  AYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAW 128

Query: 113 YNFRFEISEVNRWSDVKGT-LVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQV 171
           Y FR E     R S +     + VT   + P +  P  L  G  V   C           
Sbjct: 129 YFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTVICV---------- 178

Query: 172 RLQWQGQD-PARSVTFNSQKFEP----TGVGHLETLHMAMSWQDHGRILRCQLSVANH-- 224
              W  +  PA S ++      P        H   L    S QDH   L C +  +    
Sbjct: 179 -FNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGV 237

Query: 225 RAQSEIHLQVKYAPKGVKILLSPSGRNIL------------PGELVTLTCQVNSSYPAVS 272
            AQ  + L+V YAPK + I +S    + L             G+ + L C  +S  PA  
Sbjct: 238 SAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPA-- 295

Query: 273 SIKW-LKDGVRLQT-----KTGVLHLPQAAWSDAGVYTCQAENGVG--------SLVSPP 318
           ++ W L+D V   +     +T  L L      D+G YTC+AEN +G        S+  PP
Sbjct: 296 TLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPP 355

Query: 319 ISLHIFMAEVQVS--------PAGPILENQTVTLVCNTPNEAPSDLRYS-WYKNHVLLED 369
            +L + +++   +         + P+LE Q++ LVC T +  P+ L ++ W +     + 
Sbjct: 356 ENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQP 415

Query: 370 AHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVG 429
           +    L L        G + C  Q+  GS+    +S+ V++PP     +   E +     
Sbjct: 416 SDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVS-LSLSVHYPPQLLGPSCSWEAEG---- 470

Query: 430 ILHCSVVSE--PLATLVLSHGGHILA--STSGDSDHSPRFSGTSGPNSLRL 476
            LHCS  S+  P  +L    G  +L   S+ G  + +P  +G    +SL L
Sbjct: 471 -LHCSCSSQASPAPSLRWWLGEELLEGNSSQGSFEVTPSSAGPWANSSLSL 520



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 66/238 (27%), Positives = 99/238 (41%), Gaps = 38/238 (15%)

Query: 1145 TSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY---------------LLESHGGQLA 1189
            T   C V    +     R + L V YAP++L ++                 LE   GQ  
Sbjct: 224  TDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFL 283

Query: 1190 LVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQ 1249
             +LC  DS+PPA L+     R+L+SS     P TL LELRG +  D G Y+C A + LG 
Sbjct: 284  RLLCAADSQPPATLSWVLQDRVLSSSHPWG-PRTLGLELRGVRAGDSGRYTCRAENRLGS 342

Query: 1250 ANTSLELRL----EGVRVILA-------------PEAAVPEGAPITVTCADPAAHAPTLY 1292
               +L+L +    E +RV+++                 V EG  + + C   ++  P   
Sbjct: 343  QQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSS-PPARL 401

Query: 1293 TWYHNGRWL---QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQ 1347
            +W   G+ +   Q      L        H G ++C AQ   G++     +L V Y PQ
Sbjct: 402  SWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHV-SLSLSVHYPPQ 458



 Score = 68.6 bits (166), Expect = 5e-11
 Identities = 111/480 (23%), Positives = 181/480 (37%), Gaps = 81/480 (16%)

Query: 843  QVPSHGRFQAKAEAN--SLKLEVRELGLGDSGSY--RCEATNVLGSSNTSLFFQVRGAWV 898
            ++ +  RFQ   +    S  L +R+    D   Y  R E  + +  S  S  F ++   +
Sbjct: 96   EMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTAL 155

Query: 899  QVSPS---PE-LQEGQAVVLSCQVHTGVPE--GTSYRWYRDGQPLQESTSATLRFAAITL 952
               P    PE L+ GQ V + C  +    +    S+ W       + +  +T  F+ ++ 
Sbjct: 156  TKKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSF 215

Query: 953  TQAGAYH-----CQAQAPGSATTSLAAPISLHVSYAPRHVTLTT---------------L 992
            T +   H     C          S    + L V+YAP+ + ++                 
Sbjct: 216  TPSPQDHDTDLTCHVDFSRKGV-SAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIY 274

Query: 993  MDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRL 1052
            ++   G+   LLC  DS PPA L  +  DR+++S+      P G          P TL L
Sbjct: 275  LEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSS-----HPWG----------PRTLGL 319

Query: 1053 EIHGAMLEDEGVYICEASNTLGQASASADFDAQ-----------------AVNVQVWPGA 1095
            E+ G    D G Y C A N LG    + D   Q                   N+      
Sbjct: 320  ELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSL 379

Query: 1096 TVREGQLVNLTCLVWTTHPAQLTYT-WYQ--DGQQRLDAHSIPLPNVTVRDATSYRCGVG 1152
             V EGQ + L C+  ++ PA+L++T W Q     Q  D   + LP + +     + C   
Sbjct: 380  PVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQ 439

Query: 1153 PPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLL 1212
             P  +  +S  ++L V Y P+ L  +   E+ G   +   C+  + P   L       LL
Sbjct: 440  HPLGSQHVS--LSLSVHYPPQLLGPSCSWEAEGLHCS---CSSQASPAPSLRWWLGEELL 494

Query: 1213 -ASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAV 1271
              +S+  S   T         P   G ++ S+ S  G  ++ L LR +   V  A   +V
Sbjct: 495  EGNSSQGSFEVT---------PSSAGPWANSSLSLHGGLSSGLRLRCKAWNVHGAQSGSV 545



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 106/409 (25%), Positives = 153/409 (37%), Gaps = 75/409 (18%)

Query: 1226 LELRGPQPRDEG--FYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE----GAPITV 1279
            L +R  Q  DE   F+     S +  +  S    L+   +   P+  +PE    G P+TV
Sbjct: 116  LVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTV 175

Query: 1280 TC----ADPAAHAPTLYTWYHNGRWL---QEGPAAS----LSFLVATRAHAGAYSCQAQ- 1327
             C    A     AP+ ++W   G  L   +  P+ S    LSF  + + H    +C    
Sbjct: 176  ICVFNWAFKKCPAPS-FSW--TGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDF 232

Query: 1328 DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR---------------SMAVIQCTVDSE 1372
              +G  + R   L+V YAP+D ++S   D+ +                    + C  DS+
Sbjct: 233  SRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQ 292

Query: 1373 PPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLL 1431
            PPA L+     +VL++S   H     T         L L+++ V AGD   Y C A+N L
Sbjct: 293  PPATLSWVLQDRVLSSS---HPWGPRT---------LGLELRGVRAGDSGRYTCRAENRL 340

Query: 1432 GSISTIGRLQV----EGARVVAE-------------PGLDVPEGAALNLSCRLLGGPGPV 1474
            GS      L V    E  RV+                 L V EG +L L C     P P 
Sbjct: 341  GSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSP-PA 399

Query: 1475 GNSTFAWFWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPK 1534
              S   W              L    +     G + C A+ P G +    + L V YPP+
Sbjct: 400  RLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLG-SQHVSLSLSVHYPPQ 458

Query: 1535 TPTMMVFVEPEGGLRGILDCRVDSE--PLASLTLHLGSRLVASSQPQGA 1581
                    E EG     L C   S+  P  SL   LG  L+  +  QG+
Sbjct: 459  LLGPSCSWEAEG-----LHCSCSSQASPAPSLRWWLGEELLEGNSSQGS 502



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 126/517 (24%), Positives = 181/517 (35%), Gaps = 109/517 (21%)

Query: 464 RFSGTSGPNSLRLEIRDLEETDSGEY--KCSATNSLGNATSTLDFHANAARLLISPAAEV 521
           + +G  G  S  L IRD +  D   Y  +    + + ++  +  F      L   P   +
Sbjct: 104 QLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYI 163

Query: 522 VE----GQAVTLSC--RSGLSPTPDARFSWYLNGALL----------HEGPGSSLLLPAA 565
            E    GQ VT+ C         P   FSW   GA L          H    S    P  
Sbjct: 164 PETLEPGQPVTVICVFNWAFKKCPAPSFSW--TGAALSPRRTRPSTSHFSVLSFTPSPQD 221

Query: 566 SSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAA----------GAG 615
             TD   +   +R G SA        L V Y P+    +   D  +A             
Sbjct: 222 HDTDLTCHVDFSRKGVSAQ---RTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQ 278

Query: 616 AGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVE 675
            G+   LLC  DS PPA L  + +DRV+++S P G                  P  L +E
Sbjct: 279 KGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWG------------------PRTLGLE 320

Query: 676 IHNPLLEEEGLYLCEASNALGNASTSATFNGQ--------------ATVLAIAPSHT--- 718
           +      + G Y C A N LG+   +   + Q               TVL    + T   
Sbjct: 321 LRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLP 380

Query: 719 LQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQ--GPLE-----TVTLLPVARTDAAL 771
           + EG    L C      +  PA  SW R    W Q  GP +      + L P+       
Sbjct: 381 VLEGQSLRLVCVTH---SSPPARLSWTR----WGQTVGPSQPSDPGVLELPPIQMEHEGE 433

Query: 772 YACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFH 831
           + C      G+Q    + LSV YPP     S   +    H +   C+  + P   L  + 
Sbjct: 434 FTCHAQHPLGSQ-HVSLSLSVHYPPQLLGPSCSWEAEGLHCS---CSSQASPAPSLRWWL 489

Query: 832 GEHLLATSLGPQVPSHGRFQAKAEA------NSLKLEVRELGLGDSGSYRCEATNVLGSS 885
           GE LL  +      S G F+    +      +SL L     GL      RC+A NV G+ 
Sbjct: 490 GEELLEGN-----SSQGSFEVTPSSAGPWANSSLSLHG---GLSSGLRLRCKAWNVHGAQ 541

Query: 886 NTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGV 922
           + S+F  + G         +L+ G  + L   +  GV
Sbjct: 542 SGSVFQLLPG---------KLEHGGGLGLGAALGAGV 569



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 60/200 (30%), Positives = 82/200 (41%), Gaps = 35/200 (17%)

Query: 420 FLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIR 479
           +LE Q G    L C+  S+P ATL       +L+S           S   GP +L LE+R
Sbjct: 274 YLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSS-----------SHPWGPRTLGLELR 322

Query: 480 DLEETDSGEYKCSATNSLGNATSTLD----FHANAARLLISPA-------------AEVV 522
            +   DSG Y C A N LG+    LD    +     R+++S A               V+
Sbjct: 323 GVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVL 382

Query: 523 EGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSS---LLLPAASSTDAGSYHCRARD 579
           EGQ++ L C +  S  P AR SW   G  +     S    L LP       G + C A+ 
Sbjct: 383 EGQSLRLVCVTHSS--PPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQ- 439

Query: 580 GHSASGPSSPAVLTVLYPPR 599
            H          L+V YPP+
Sbjct: 440 -HPLGSQHVSLSLSVHYPPQ 458



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 36/119 (30%), Positives = 53/119 (44%), Gaps = 27/119 (22%)

Query: 1518 GAAASAPVMLRVLYPPKTPTM---------------MVFVEPEGGLRGILDCRVDSEPLA 1562
            G +A   V LRV Y PK   +               ++++E + G    L C  DS+P A
Sbjct: 236  GVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPA 295

Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621
            +L+  L  R+++SS P G            P  L +++  +R  D G Y C A N LGS
Sbjct: 296  TLSWVLQDRVLSSSHPWG------------PRTLGLELRGVRAGDSGRYTCRAENRLGS 342



 Score = 38.1 bits (87), Expect = 0.074
 Identities = 50/198 (25%), Positives = 71/198 (35%), Gaps = 39/198 (19%)

Query: 1453 LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP-----VPTLAFTHVARAQAG 1507
            L+V +G  L L C     P     +T +W   DR L +          L    V    +G
Sbjct: 275  LEVQKGQFLRLLCAADSQPP----ATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSG 330

Query: 1508 MYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI---------------L 1552
             Y C AE   G+   A + L V YPP+   +MV       L  +               L
Sbjct: 331  RYTCRAENRLGSQQQA-LDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRL 389

Query: 1553 DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612
             C   S P A L+     + V  SQP            + P  L  ++  ++   +GE+ 
Sbjct: 390  VCVTHSSPPARLSWTRWGQTVGPSQP------------SDPGVL--ELPPIQMEHEGEFT 435

Query: 1613 CSASNVLGSASTSTYFGV 1630
            C A + LGS   S    V
Sbjct: 436  CHAQHPLGSQHVSLSLSV 453


>gi|31377639 sialic acid binding Ig-like lectin 10 [Homo sapiens]
          Length = 697

 Score =  108 bits (269), Expect = 6e-23
 Identities = 131/524 (25%), Positives = 215/524 (41%), Gaps = 74/524 (14%)

Query: 8   LLLASFFPAGQASWG---VSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYS 64
           LLL+S     QA  G   +   + V   +G C+ +PC FS+P       G T  + Y + 
Sbjct: 5   LLLSSLLGGSQAMDGRFWIRVQESVMVPEGLCISVPCSFSYPRQDWT--GSTPAYGYWFK 62

Query: 65  GQRQV-----VSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEI 119
              +      V+ +   + VE   RGR +  G+P    C+L+++D Q +D   Y FR E 
Sbjct: 63  AVTETTKGAPVATNHQSREVEMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFRVER 122

Query: 120 SEVNRWSDVK-GTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQ-EQVRLQWQG 177
               R++ +  G  + VT   + P +  P  L  G  V   C   +   +       W G
Sbjct: 123 GSYVRYNFMNDGFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSWTG 182

Query: 178 QDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANH--RAQSEIHLQVK 235
                    +SQ  +PT   H   L      QDH   L C +  +     AQ  + L+V 
Sbjct: 183 ------AALSSQGTKPT-TSHFSVLSFTPRPQDHNTDLTCHVDFSRKGVSAQRTVRLRVA 235

Query: 236 YAPKGVKILLS--------PSGRNILP------GELVTLTCQVNSSYPAVSSIKWLKDGV 281
           YAP+ + I +S        P  +  +P      G+ + L C  +S  PA  ++ W+    
Sbjct: 236 YAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQPPA--TLSWVLQNR 293

Query: 282 RLQT------KTGVLHLPQAAWSDAGVYTCQAENGVG--------SLVSPPISLHIFMAE 327
            L +      +   L LP     D+G YTC+AEN +G        S+  PP +L + +++
Sbjct: 294 VLSSSHPWGPRPLGLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQ 353

Query: 328 VQVS--------PAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLL---EDAHSHTLR 376
              +         + P+LE Q++ LVC T +  P+  R SW +   +L   + +    L 
Sbjct: 354 ANRTVLENLGNGTSLPVLEGQSLCLVCVTHSSPPA--RLSWTQRGQVLSPSQPSDPGVLE 411

Query: 377 LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVV 436
           L        G + C  ++  GS+    +S+ V++ P     +   E +      LHCS  
Sbjct: 412 LPRVQVEHEGEFTCHARHPLGSQHVS-LSLSVHYSPKLLGPSCSWEAEG-----LHCSCS 465

Query: 437 SE--PLATLVLSHGGHILASTSGDS--DHSPRFSGTSGPNSLRL 476
           S+  P  +L    G  +L   S     + +P  +G    +SL L
Sbjct: 466 SQASPAPSLRWWLGEELLEGNSSQDSFEVTPSSAGPWANSSLSL 509



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 77/265 (29%), Positives = 116/265 (43%), Gaps = 33/265 (12%)

Query: 1093 PGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH-------SIPLPNVTVRDAT 1145
            P    ++GQ + L C   +  PA  T +W    +    +H        + LP V   D+ 
Sbjct: 262  PYLEAQKGQFLRLLCAADSQPPA--TLSWVLQNRVLSSSHPWGPRPLGLELPGVKAGDSG 319

Query: 1146 SYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY------LLESHG---------GQLAL 1190
             Y C      R     R + L V Y P NLR+        +LE+ G         GQ   
Sbjct: 320  RYTCRA--ENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLC 377

Query: 1191 VLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQA 1250
            ++C   S PPA+L+ +  G++L+ S  +  P  L  EL   Q   EG ++C AR PLG  
Sbjct: 378  LVCVTHSSPPARLSWTQRGQVLSPSQPSD-PGVL--ELPRVQVEHEGEFTCHARHPLGSQ 434

Query: 1251 NTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLS 1310
            + SL L +     +L P  +  E   +  +C+  A+ AP+L  W   G  L EG ++  S
Sbjct: 435  HVSLSLSVHYSPKLLGPSCSW-EAEGLHCSCSSQASPAPSLRWWL--GEELLEGNSSQDS 491

Query: 1311 FLVATRAHAGAYSCQAQDAQGTRSS 1335
            F V T + AG ++  +    G  SS
Sbjct: 492  FEV-TPSSAGPWANSSLSLHGGLSS 515



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 111/475 (23%), Positives = 176/475 (37%), Gaps = 85/475 (17%)

Query: 843  QVPSHGRFQAKAEA--NSLKLEVRELGLGDSGSY--RCEATNVLGSSNTSLFFQVRGAWV 898
            ++ + GRFQ   +    +  L +R+  + D   Y  R E  + +  +  +  F ++   +
Sbjct: 83   EMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFRVERGSYVRYNFMNDGFFLKVTAL 142

Query: 899  QVSPS---PE-LQEGQAVVLSCQVHTGVPE--GTSYRWYRDGQPLQESTSATLRFAAITL 952
               P    PE L+ GQ V + C  +    E    S+ W       Q +   T  F+ ++ 
Sbjct: 143  TQKPDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSWTGAALSSQGTKPTTSHFSVLSF 202

Query: 953  TQAGAYH-----CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP---------- 997
            T     H     C          S    + L V+YAPR + ++   D  P          
Sbjct: 203  TPRPQDHNTDLTCHVDFSRKGV-SAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNV 261

Query: 998  -------GRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTL 1050
                   G+   LLC  DS PPA L  +  +R+++S+      P G          P  L
Sbjct: 262  PYLEAQKGQFLRLLCAADSQPPATLSWVLQNRVLSSS-----HPWG----------PRPL 306

Query: 1051 RLEIHGAMLEDEGVYICEASNTLGQASASADFDAQ-----------------AVNVQVWP 1093
             LE+ G    D G Y C A N LG    + D   Q                   N+    
Sbjct: 307  GLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGT 366

Query: 1094 GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQ-----QRLDAHSIPLPNVTVRDATSYR 1148
               V EGQ + L C+  ++ PA+L  +W Q GQ     Q  D   + LP V V     + 
Sbjct: 367  SLPVLEGQSLCLVCVTHSSPPARL--SWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFT 424

Query: 1149 CGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHA 1208
            C    P  +  +S  ++L V Y+P+ L  +   E+ G   +   C+  + P   L     
Sbjct: 425  CHARHPLGSQHVS--LSLSVHYSPKLLGPSCSWEAEGLHCS---CSSQASPAPSLRWWLG 479

Query: 1209 GRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRV 1263
              LL  +++               P   G ++ S+ S  G  ++ L LR E   V
Sbjct: 480  EELLEGNSSQDSFEV--------TPSSAGPWANSSLSLHGGLSSGLRLRCEAWNV 526



 Score = 68.6 bits (166), Expect = 5e-11
 Identities = 64/240 (26%), Positives = 100/240 (41%), Gaps = 40/240 (16%)

Query: 1145 TSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY-----------------LLESHGGQ 1187
            T   C V    +     R + L V YAPR+L ++                   LE+  GQ
Sbjct: 211  TDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQ 270

Query: 1188 LALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPL 1247
               +LC  DS+PPA L+     R+L+SS     P  L LEL G +  D G Y+C A + L
Sbjct: 271  FLRLLCAADSQPPATLSWVLQNRVLSSSHPWG-PRPLGLELPGVKAGDSGRYTCRAENRL 329

Query: 1248 GQANTSLELRL----EGVRVILA-------------PEAAVPEGAPITVTCADPAAHAPT 1290
            G    +L+L +    E +RV+++                 V EG  + + C   ++  P 
Sbjct: 330  GSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLCLVCVTHSS-PPA 388

Query: 1291 LYTWYHNGRWLQEGPAASLSFLVATRA---HAGAYSCQAQDAQGTRSSRPAALQVLYAPQ 1347
              +W   G+ L     +    L   R    H G ++C A+   G++     +L V Y+P+
Sbjct: 389  RLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCHARHPLGSQHV-SLSLSVHYSPK 447



 Score = 61.2 bits (147), Expect = 8e-09
 Identities = 60/200 (30%), Positives = 81/200 (40%), Gaps = 35/200 (17%)

Query: 420 FLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIR 479
           +LE Q G    L C+  S+P ATL       +L+S           S   GP  L LE+ 
Sbjct: 263 YLEAQKGQFLRLLCAADSQPPATLSWVLQNRVLSS-----------SHPWGPRPLGLELP 311

Query: 480 DLEETDSGEYKCSATNSLGNATSTLD----FHANAARLLISPA-------------AEVV 522
            ++  DSG Y C A N LG+    LD    +     R+++S A               V+
Sbjct: 312 GVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVL 371

Query: 523 EGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSS---LLLPAASSTDAGSYHCRARD 579
           EGQ++ L C +  S  P AR SW   G +L     S    L LP       G + C AR 
Sbjct: 372 EGQSLCLVCVTHSS--PPARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCHAR- 428

Query: 580 GHSASGPSSPAVLTVLYPPR 599
            H          L+V Y P+
Sbjct: 429 -HPLGSQHVSLSLSVHYSPK 447



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 96/366 (26%), Positives = 131/366 (35%), Gaps = 75/366 (20%)

Query: 1267 PEAAVPE----GAPITVTCADPAAHA---PTLYTWYHNGRWLQ-EGPAAS----LSFLVA 1314
            P+  +PE    G P+TV C    A     P  ++W       Q   P  S    LSF   
Sbjct: 146  PDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSWTGAALSSQGTKPTTSHFSVLSFTPR 205

Query: 1315 TRAHAGAYSCQAQ-DAQGTRSSRPAALQVLYAPQDAVLSSFRD----------------- 1356
             + H    +C      +G  + R   L+V YAP+D V+S  RD                 
Sbjct: 206  PQDHNTDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLE 265

Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416
            ++      + C  DS+PPA L+     +VL++S           H    R  L L++  V
Sbjct: 266  AQKGQFLRLLCAADSQPPATLSWVLQNRVLSSS-----------HPWGPR-PLGLELPGV 313

Query: 1417 PAGDD-TYVCTAQNLLGSISTIGRLQV----EGARVVAE-------------PGLDVPEG 1458
             AGD   Y C A+N LGS      L V    E  RV+                 L V EG
Sbjct: 314  KAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEG 373

Query: 1459 AALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQA---GMYHCLAEL 1515
             +L L C     P     +  +W    + L            + R Q    G + C A  
Sbjct: 374  QSLCLVCVTHSSP----PARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCHARH 429

Query: 1516 PTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSE--PLASLTLHLGSRLV 1573
            P G +    + L V Y PK        E EG     L C   S+  P  SL   LG  L+
Sbjct: 430  PLG-SQHVSLSLSVHYSPKLLGPSCSWEAEG-----LHCSCSSQASPAPSLRWWLGEELL 483

Query: 1574 ASSQPQ 1579
              +  Q
Sbjct: 484  EGNSSQ 489



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 117/475 (24%), Positives = 163/475 (34%), Gaps = 80/475 (16%)

Query: 464 RFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD--FHANAARLLISPAAEV 521
           + +G     +  L IRD +  D  +Y            + ++  F      L   P   +
Sbjct: 91  QLTGDPAKGNCSLVIRDAQMQDESQYFFRVERGSYVRYNFMNDGFFLKVTALTQKPDVYI 150

Query: 522 VE----GQAVTLSC--RSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHC 575
            E    GQ VT+ C         P   FSW   GA L     S    P  S     S+  
Sbjct: 151 PETLEPGQPVTVICVFNWAFEECPPPSFSW--TGAAL----SSQGTKPTTSHFSVLSFTP 204

Query: 576 RARDGH---------SASGPSSPAV--LTVLYPPRQPTFTTRLDLDAA------------ 612
           R +D +         S  G S+     L V Y PR    +   D   A            
Sbjct: 205 RPQDHNTDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYL 264

Query: 613 GAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLL 672
            A  G+   LLC  DS PPA L  + ++RV+++S P G                  P  L
Sbjct: 265 EAQKGQFLRLLCAADSQPPATLSWVLQNRVLSSSHPWG------------------PRPL 306

Query: 673 RVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQ--------------ATVLAIAPSHT 718
            +E+      + G Y C A N LG+   +   + Q               TVL    + T
Sbjct: 307 GLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGT 366

Query: 719 LQEGTEANLTCNVSREAAGSPANFSWFRNG-VLWAQGPLETVTL-LPVARTD-AALYACR 775
                E    C V    +  PA  SW + G VL    P +   L LP  + +    + C 
Sbjct: 367 SLPVLEGQSLCLVCVTHSSPPARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCH 426

Query: 776 ILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHL 835
                G+Q    + LSV Y P     S   +    H +   C+  + P   L  + GE L
Sbjct: 427 ARHPLGSQ-HVSLSLSVHYSPKLLGPSCSWEAEGLHCS---CSSQASPAPSLRWWLGEEL 482

Query: 836 LATSLGPQVPSHGRFQAKAEAN-SLKLEVRELGLGDSGSYRCEATNVLGSSNTSL 889
           L  +            A   AN SL L     GL      RCEA NV G+ + S+
Sbjct: 483 LEGNSSQDSFEVTPSSAGPWANSSLSLHG---GLSSGLRLRCEAWNVHGAQSGSI 534



 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 36/121 (29%), Positives = 55/121 (45%), Gaps = 29/121 (23%)

Query: 1518 GAAASAPVMLRVLYPPK----------TPTM-------MVFVEPEGGLRGILDCRVDSEP 1560
            G +A   V LRV Y P+          TP +       + ++E + G    L C  DS+P
Sbjct: 223  GVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQP 282

Query: 1561 LASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620
             A+L+  L +R+++SS P G            P  L +++  ++  D G Y C A N LG
Sbjct: 283  PATLSWVLQNRVLSSSHPWG------------PRPLGLELPGVKAGDSGRYTCRAENRLG 330

Query: 1621 S 1621
            S
Sbjct: 331  S 331



 Score = 37.7 bits (86), Expect = 0.096
 Identities = 53/200 (26%), Positives = 77/200 (38%), Gaps = 39/200 (19%)

Query: 1451 PGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAE----PVPT-LAFTHVARAQ 1505
            P L+  +G  L L C     P     +T +W   +R L +     P P  L    V    
Sbjct: 262  PYLEAQKGQFLRLLCAADSQPP----ATLSWVLQNRVLSSSHPWGPRPLGLELPGVKAGD 317

Query: 1506 AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI-------------- 1551
            +G Y C AE   G+   A + L V YPP+   +MV       L  +              
Sbjct: 318  SGRYTCRAENRLGSQQRA-LDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSL 376

Query: 1552 -LDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGE 1610
             L C   S P A L+     ++++ SQP    ++P +  L      RV +E      +GE
Sbjct: 377  CLVCVTHSSPPARLSWTQRGQVLSPSQP----SDPGVLELP-----RVQVE-----HEGE 422

Query: 1611 YICSASNVLGSASTSTYFGV 1630
            + C A + LGS   S    V
Sbjct: 423  FTCHARHPLGSQHVSLSLSV 442


>gi|144226847 obscurin-like 1 [Homo sapiens]
          Length = 1896

 Score =  106 bits (265), Expect = 2e-22
 Identities = 323/1368 (23%), Positives = 470/1368 (34%), Gaps = 256/1368 (18%)

Query: 190  KFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSG 249
            + E  G+ H   LH A+  QD G ++      +    Q    L ++ +P  +   LSP  
Sbjct: 671  RIEQKGLQHRLILH-AVKHQDSGALV----GFSCPGVQDSAALTIQESPVHI---LSPQD 722

Query: 250  RNILP---GELVTLTCQVNS-SYPAVSSIKWLKDG----------VRLQTKTGVLHLPQA 295
            R  L     E V LTC+++   +PA     W KDG          V++  +   L LP+A
Sbjct: 723  RVSLTFTTSERVVLTCELSRVDFPAT----WYKDGQKVEESELLVVKMDGRKHRLILPEA 778

Query: 296  AWSDAGVYTCQAEN-----GVGSLVSPPISL-----HIFMAEVQVSPAGPILENQTVTLV 345
               D+G + C+ E      GV ++  PP+ +     H+F+  +          ++ V L 
Sbjct: 779  KVQDSGEFECRTEGVSAFFGV-TVQDPPVHIVDPREHVFVHAI---------TSECVMLA 828

Query: 346  CNTPNEAPSDLRYSWYK--------NHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHG 397
            C    E   D    WYK        + V+LE+   H   +  AT+   G    E Q V G
Sbjct: 829  CEVDRE---DAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDG---GEFQCVAG 882

Query: 398  SERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSG 457
             E +     + +       +++++   +G V +    +    L   +      +  +  G
Sbjct: 883  DECAYFTVTITD-------VSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDG 935

Query: 458  DS-DHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLIS 516
            +    SP           RL +  ++  DSGEY C   +   + T T+         +I 
Sbjct: 936  EEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTV---TEPPVRIIY 992

Query: 517  PAAEVVEGQAVTLSCRSGLS--PTPDARFSWYLNG---------ALLHEGPGSSLLLPAA 565
            P  EV    AVTL C   +      DA   WY +G          L  +GP   L+LPAA
Sbjct: 993  PRDEVTL-IAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAA 1051

Query: 566  SSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCR 625
               D G + C A D       S+   +TV  PP +        LD      GR  L   R
Sbjct: 1052 QPEDGGEFVCDAGD------DSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVEL---R 1102

Query: 626  VDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685
             +  P       +KD +              G   P   +T         + +   E+ G
Sbjct: 1103 CEVAPAGSQVRWYKDGLEV----EASDALQLGAEGPTRTLT---------LPHAQPEDAG 1149

Query: 686  LYLCEASNALGNASTSATFN-------GQATVLAIAPSH-TLQEGTEANLTCNVSREAAG 737
             Y+CE  +       + TFN        Q   L   PS   +  G    L+C +SR  AG
Sbjct: 1150 EYVCETRH------EAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSR--AG 1201

Query: 738  SPANFSWFRNG---------VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPV 788
            +P    W  NG          L A+GP   + +       A LY C    ++GA    P 
Sbjct: 1202 APV--VWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTC----QSGAAPGAPS 1255

Query: 789  LLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALF-----HGEHLLATSLGPQ 843
            L   +   + P      +  Q         V S P   L L       G  +     G +
Sbjct: 1256 LSFTVQVAEPPVRVVAPEAAQ-------TRVRSTPGGDLELVVHLSGPGGPVRWYKDGER 1308

Query: 844  VPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPS 903
            + S GR Q +       L V+    GD+G Y C+A         S+   +    V     
Sbjct: 1309 LASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTP 1368

Query: 904  PELQEGQAVVLSCQVHTGVPEGTSYRWYRDG---------QPLQESTSATLRFAAITLTQ 954
              + EG      C+V    P      W R+G         +  Q  +S  L      L  
Sbjct: 1369 LTVHEGDDATFRCEVS---PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGD 1425

Query: 955  AGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQ 1014
            AG    +A   GS  TS      LHV      + L  L D           R +      
Sbjct: 1426 AGTVTLRA---GSTATS----ARLHVR-ETELLFLRRLQDV----------RAEEGQDVC 1467

Query: 1015 LRLLHGDRLVASTLQGV--GGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA--S 1070
            L +  G    A  ++ V  G P     RL +A   +  RL IHG +L D+G Y CE+   
Sbjct: 1468 LEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHD 1527

Query: 1071 NTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLD 1130
             TL + S       Q   ++     T+ EG                +T  W + G Q   
Sbjct: 1528 RTLARLSVR---PRQLRVLRPLEDVTISEGGSATFQL---ELSQEGVTGEWARGGVQLYP 1581

Query: 1131 A-----------HSIPLPNVTVRD-------ATSYRCGVGPPGRAPRLSRPITLDVLYAP 1172
                        H + L  + + D       A S RC       A  + R + + ++  P
Sbjct: 1582 GPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCA------ARLIVREVPVTIVRGP 1635

Query: 1173 RNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVP--NTLR-LELR 1229
             +L +T       G  A   C + S+  A +     G  L  S    +    T R L+LR
Sbjct: 1636 HDLEVT------EGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLR 1688

Query: 1230 GPQPRDEGFYSCS-ARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHA 1288
               P D G YSC+   +  G    ++  R   V   L   +A  EG   T  C    +  
Sbjct: 1689 RCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSA-REGDGATFECT--VSEV 1745

Query: 1289 PTLYTWYHNGRWL---------QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAA 1339
             T   W   GR L         QEG    L         AG    QA  AQ       A 
Sbjct: 1746 ETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSL-----AL 1800

Query: 1340 LQVLYAPQDAVLSSFRDSR--ARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLAS 1397
            L+V   P        R+        AV++ TV S     +    +G  L         + 
Sbjct: 1801 LEVEALPLQMCRHPPREKTVLVGRRAVLEVTV-SRSGGHVCWLREGAELCPGDKYEMRSH 1859

Query: 1398 GTGHVQVARNALRLQVQDV-PAGDDTYVCTAQNLLGSISTIGRLQVEG 1444
            G  H         L + DV P    TY C A    G  ST  RL VEG
Sbjct: 1860 GPTH--------SLVIHDVRPEDQGTYCCQA----GQDSTHTRLLVEG 1895



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 290/1335 (21%), Positives = 442/1335 (33%), Gaps = 273/1335 (20%)

Query: 244  LLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRL--------------QTKTG- 288
            L  P  + +L G  V LTC+         ++ W KDG+ L              + + G 
Sbjct: 131  LTGPRSQWVLRGAEVVLTCRAGGL--PEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP 188

Query: 289  ----VLHLPQAAWSDAGVYTCQAENGVG--------SLVSPPISLHIFMAEVQVSPAGPI 336
                 L +  A   D+GVY C A N  G         +  PP S      E       P+
Sbjct: 189  GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248

Query: 337  L---------ENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH---------SHTLRLH 378
                      E +     C    +   ++ + W +   LL D              L++ 
Sbjct: 249  KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHW-EGRPLLPDRRRLMYRDRDGGFVLKVL 307

Query: 379  LATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGL---VGILHCSV 435
                 D G Y C  +N  G   S  V + V  P L    T  L+   G    + +L C V
Sbjct: 308  YCQAKDRGLYVCAARNSAGQTLSA-VQLHVKEPRLR--FTRPLQDVEGREHGIAVLECKV 364

Query: 436  VSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSA-- 493
             +  + T        +L           ++         RL I  L+  D G Y C    
Sbjct: 365  PNSRIPTAWFREDQRLLPCR--------KYEQIEEGTVRRLIIHRLKADDDGIYLCEMRG 416

Query: 494  -TNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALL 552
               ++ N T          R L     +V+EG+   L   + L    + R  W  +G  L
Sbjct: 417  RVRTVANVTVKGPILKRLPRKL-----DVLEGENAVLLVET-LEAGVEGR--WSRDGEEL 468

Query: 553  ------HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTR 606
                    G   +L+LP  +  DAG        G+S +            PP  P     
Sbjct: 469  PVICQSSSGHMHALVLPGVTREDAGEVTFSL--GNSRTTTLLRVKCVKHSPPGPPILAEM 526

Query: 607  LDLDAAGAGAGRRGLLLCRVDSDPPA----------RLQLLHKDRVVATSLPSGGGCSTC 656
                      G +  +L       PA          R ++  +D +   S+   G     
Sbjct: 527  FK--------GHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVP 578

Query: 657  GGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNA-STSATFNGQA----TVL 711
            G C P                      EG Y        G+  S    F+G A    T  
Sbjct: 579  GDCVP---------------------SEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTAR 617

Query: 712  AIAPSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRNGV-------------------L 750
             +A    +Q  +G +A  + ++S    G+     WF NG                    +
Sbjct: 618  LVAGLEDVQVYDGEDAVFSLDLSTIIQGT-----WFLNGEELKSNEPEGQVEPGALRYRI 672

Query: 751  WAQGPLETVTLLPVARTDAAL---YACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDM 807
              +G    + L  V   D+     ++C  + ++ A       + +L P DR  L+     
Sbjct: 673  EQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTS- 731

Query: 808  GQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELG 867
                    + T +   +   A ++ +       G +V        K +    +L + E  
Sbjct: 732  -----ERVVLTCELSRVDFPATWYKD-------GQKVEESELLVVKMDGRKHRLILPEAK 779

Query: 868  LGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE----------GQAVVLSCQ 917
            + DSG + C    V      S FF   G  VQ  P   +             + V+L+C+
Sbjct: 780  VQDSGEFECRTEGV------SAFF---GVTVQDPPVHIVDPREHVFVHAITSECVMLACE 830

Query: 918  VHTGVPEGTSYRWYRDGQPLQESTSATL------RFAAITLTQ---AGAYHCQAQAPGSA 968
            V     E    RWY+DGQ ++ES    L      R   +  TQ    G + C A    + 
Sbjct: 831  VDR---EDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAY 887

Query: 969  TTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLH-GDRLVAST 1027
             T     +S  + Y P        +      L   LCR    P A++R    G+ +V   
Sbjct: 888  FTVTITDVSSWIVY-PSGKVYVAAVRLERVVLTCELCR----PWAEVRWTKDGEEVV--- 939

Query: 1028 LQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAV 1087
                      SP L +       RL +    LED G Y+CE  +    AS +       V
Sbjct: 940  ---------ESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDE--SASFTVTVTEPPV 988

Query: 1088 NVQVWPGATVREGQLVNLTCLVWTTHPAQ--LTYTWYQDGQQRLDAHSIPL--------- 1136
             + ++P   V     V L C+V     ++      WY+DG +  ++ ++ L         
Sbjct: 989  RI-IYPRDEVTL-IAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRL 1046

Query: 1137 --PNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNL--RLTYLLESHGGQLALVL 1192
              P     D   + C  G        S   T+ V   P  +       L+ H G    V 
Sbjct: 1047 VLPAAQPEDGGEFVCDAGDD------SAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVE 1100

Query: 1193 CTVDSRPP-AQLALSHAGRLLASSTAASVPN---TLRLELRGPQPRDEGFYSCSARSPLG 1248
               +  P  +Q+     G  + +S A  +     T  L L   QP D G Y C  R    
Sbjct: 1101 LRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAI 1160

Query: 1249 QANTSLE---LRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEG- 1304
              N  L    ++   +    +P    P G P+ ++C    A AP +  W HNGR +QEG 
Sbjct: 1161 TFNVILAEPPVQFLALETTPSPLCVAP-GEPVVLSCELSRAGAPVV--WSHNGRPVQEGE 1217

Query: 1305 --------PAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRD 1356
                    P   L    A  AHAG Y+CQ+  A G   S    +QV   P   V      
Sbjct: 1218 GLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGA-PSLSFTVQVAEPPVRVVAPEAAQ 1276

Query: 1357 SRARSM--AVIQCTVD-SEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQV 1413
            +R RS     ++  V  S P   +    DG+ LA+   V    +G   V        L+V
Sbjct: 1277 TRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQV--------LRV 1328

Query: 1414 QDVPAGD-DTYVCTA 1427
            Q   +GD   Y+C A
Sbjct: 1329 QGARSGDAGEYLCDA 1343



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 267/1242 (21%), Positives = 418/1242 (33%), Gaps = 214/1242 (17%)

Query: 475  RLEIRDLEETDSGEYKC---SATNSLGNATSTLDFHANAARLLISPAAEV----VEGQAV 527
            RL + + +  DSGE++C     +   G        H      ++ P   V    +  + V
Sbjct: 772  RLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVH------IVDPREHVFVHAITSECV 825

Query: 528  TLSCRSGLSPTPDARFSWYLNG---------ALLHEGPGSSLLLPAASSTDAGSYHCRAR 578
             L+C        DA   WY +G          L +EGP   L+LPA   +D G + C A 
Sbjct: 826  MLACEVDRE---DAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAG 882

Query: 579  DGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLH 638
            D  +    +   V + +  P    +   + L+        R +L C +   P A ++   
Sbjct: 883  DECAYFTVTITDVSSWIVYPSGKVYVAAVRLE--------RVVLTCEL-CRPWAEVRWTK 933

Query: 639  KDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNA 698
                V  S              P + + K   + R+ +    LE+ G YLCE  +   + 
Sbjct: 934  DGEEVVES--------------PALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASF 979

Query: 699  STSATF--------NGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFRNG-- 748
            + + T           + T++A+     +       L C +SRE     A   W+++G  
Sbjct: 980  TVTVTEPPVRIIYPRDEVTLIAVTLECVV-------LMCELSRE----DAPVRWYKDGLE 1028

Query: 749  -------VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDR--P 799
                   VL   GP   + L      D   + C    +AG   S    ++V  PP+R   
Sbjct: 1029 VEESEALVLERDGPRCRLVLPAAQPEDGGEFVC----DAGDD-SAFFTVTVTAPPERIVH 1083

Query: 800  KLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSL 859
              +  LD+  G         +  P      ++ +       G +V +    Q  AE  + 
Sbjct: 1084 PAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKD-------GLEVEASDALQLGAEGPTR 1136

Query: 860  KLEVRELGLGDSGSYRCEATNVLGSSNTSLFF-QVRGAWVQVSPSPE-LQEGQAVVLSCQ 917
             L +      D+G Y CE  +   + N  L    V+   ++ +PSP  +  G+ VVLSC+
Sbjct: 1137 TLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCE 1196

Query: 918  VHTGVPEGTSYRWYRDGQPLQESTSATLR---------FAAITLTQAGAYHCQA-QAPGS 967
            +      G    W  +G+P+QE     L            A     AG Y CQ+  APG+
Sbjct: 1197 LSRA---GAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGA 1253

Query: 968  ATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVAST 1027
             + S     ++ V+  P  V       T          RV S P   L L+         
Sbjct: 1254 PSLS----FTVQVAEPPVRVVAPEAAQT----------RVRSTPGGDLELV-------VH 1292

Query: 1028 LQGVGGPE---------GSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASA 1078
            L G GGP           S  R+ +  A     L + GA   D G Y+C+A         
Sbjct: 1293 LSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLV 1352

Query: 1079 SADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPL-P 1137
            S +       V      TV EG      C V    P     TW ++G        + +  
Sbjct: 1353 SVEEPLLVKLVSELTPLTVHEGDDATFRCEV---SPPDADVTWLRNGAVVTPGPQVEMAQ 1409

Query: 1138 NVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLE------SHGGQLALV 1191
            N + R  T   C +G  G     +           R   L +L          G  + L 
Sbjct: 1410 NGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLE 1469

Query: 1192 LCTVDSRPPAQLALSHAGRLLASSTAASVP---NTLRLELRGPQPRDEGFYSCSARSPLG 1248
            + T        +     G+ L   +  S+    +  RL + G    D+G Y C +     
Sbjct: 1470 VETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRT 1529

Query: 1249 QANTSLELRLEGVRVILAPE-AAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAA 1307
             A   L +R   +RV+   E   + EG   T       +       W   G  L  GP  
Sbjct: 1530 LAR--LSVRPRQLRVLRPLEDVTISEGGSATFQL--ELSQEGVTGEWARGGVQLYPGPKC 1585

Query: 1308 SLSF------LVATRAHAGAYSCQAQDAQGTRSS-----RPAALQVLYAPQDAVLSSFRD 1356
             +        LV          C +  A   R +     R   + ++  P D  ++    
Sbjct: 1586 HIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTE--- 1642

Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416
                  A  +C + S+  A++    DG  L  S  +   A GT      R  L+L+ +  
Sbjct: 1643 ---GDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGT------RRLLQLR-RCG 1691

Query: 1417 PAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNLSCRL--------- 1467
            P+   TY C           +   +   A +     +   EG      C +         
Sbjct: 1692 PSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRW 1751

Query: 1468 -LGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHV--ARAQAGMYHCLAELPTGAAASAP 1524
             LGG  P+          + + H   +  L        R QAG    LA L   A    P
Sbjct: 1752 ELGG-RPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEA---LP 1807

Query: 1525 VMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAE 1584
            + +   +PP+  T++V      G R +L+  V         L  G+ L    + +     
Sbjct: 1808 LQM-CRHPPREKTVLV------GRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHG 1860

Query: 1585 PHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTST 1626
            P  H L         I  +RP DQG Y C A    G  ST T
Sbjct: 1861 P-THSLV--------IHDVRPEDQGTYCCQA----GQDSTHT 1889



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 96/410 (23%), Positives = 138/410 (33%), Gaps = 90/410 (21%)

Query: 247 PSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAA 296
           P    ++ G    L C V    P V  + W K G +L     +          L L  A 
Sbjct: 18  PRPVRVVSGAEAELKCVVLGEPPPV--VVWEKGGQQLAASERLSFPADGAEHGLLLTAAL 75

Query: 297 WSDAGVYTCQAENGVG--------SLVSPPISLHIFMAEVQVSPA------------GP- 335
            +DAGVY C+A N  G        +++ PP S        +  P+            GP 
Sbjct: 76  PTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPR 135

Query: 336 ---ILENQTVTLVCNTPNEAPSDLRYS---------WYKNHVLLEDAHSH-------TLR 376
              +L    V L C         L +          W  +H  L+   +         LR
Sbjct: 136 SQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALR 195

Query: 377 LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVV 436
           +  A   D+G Y C  +N HG  ++G + + V+ PP +P      E  A +V  L C+  
Sbjct: 196 ILAARLPDSGVYVCHARNAHGHAQAGAL-LQVHQPPESPPADPD-EAPAPVVEPLKCAP- 252

Query: 437 SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSG-----PNSLRLEIRD----------- 480
                T  ++ G H            P            P+  RL  RD           
Sbjct: 253 ----KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLY 308

Query: 481 LEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQ---AVTLSCRSGLSP 537
            +  D G Y C+A NS G   S +  H    RL  +   + VEG+      L C+   S 
Sbjct: 309 CQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSR 368

Query: 538 TPDARFSWYLNGALL---------HEGPGSSLLLPAASSTDAGSYHCRAR 578
            P A   W+     L          EG    L++    + D G Y C  R
Sbjct: 369 IPTA---WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMR 415



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 92/368 (25%), Positives = 129/368 (35%), Gaps = 78/368 (21%)

Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLR---LELRGPQPRDEGFYSCS 1242
            G  A + C V   PP  +     G+ LA+S   S P       L L    P D G Y C 
Sbjct: 26   GAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCR 85

Query: 1243 ARSPLGQANTSLELRL-----------------------EGVRVILAPEAA--VPEGAPI 1277
            AR+  G+A  +  + +                       EG  V L    +  V  GA +
Sbjct: 86   ARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEV 145

Query: 1278 TVTCADPAAHAPTLYTWYHNGRWLQE----------------GPAASLS--FLVATRAHA 1319
             +TC       PTLY W  +G  L E                GP ASL+   L A    +
Sbjct: 146  VLTCRAGGLPEPTLY-WEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDS 204

Query: 1320 GAYSCQAQDAQGTRSSRPAALQVLYAPQD----------AVLSSFRDS------RARSMA 1363
            G Y C A++A G  +   A LQV   P+            V+   + +           A
Sbjct: 205  GVYVCHARNAHG-HAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHA 263

Query: 1364 VIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTY 1423
              +C V  +P  E+    +G+ L             G   +    L  Q +D       Y
Sbjct: 264  KFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVL--KVLYCQAKD----RGLY 317

Query: 1424 VCTAQNLLGSISTIGRLQVEGARV-VAEPGLDVP--EGAALNLSCRLLGGPGPVGNSTFA 1480
            VC A+N  G   +  +L V+  R+    P  DV   E     L C++     P      A
Sbjct: 318  VCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKV-----PNSRIPTA 372

Query: 1481 WFWNDRRL 1488
            WF  D+RL
Sbjct: 373  WFREDQRL 380



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 108/442 (24%), Positives = 153/442 (34%), Gaps = 94/442 (21%)

Query: 554 EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPR-----QPTFTTRLD 608
           +G    LLL AA  TDAG Y CRAR  ++A    + A +TVL PP      QP     L 
Sbjct: 63  DGAEHGLLLTAALPTDAGVYVCRAR--NAAGEAYAAAAVTVLEPPASDPELQPA-ERPLP 119

Query: 609 LDAAGAGA--------------GRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCS 654
              +G GA              G   +L CR    P   L    KD +    +      +
Sbjct: 120 SPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTL-YWEKDGMALDEVWDSSHFA 178

Query: 655 TCGGCSPRMKVTKAPNL-LRVEIHNPLLEEEGLYLCEASNALGNASTSATFN-------- 705
              G     +    P   L + I    L + G+Y+C A NA G+A   A           
Sbjct: 179 LQPG-----RAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP 233

Query: 706 ----GQATVLAIAP------SHTLQEGTEANLTCNVSREAAGSP-ANFSWFRNGVLWAQG 754
                +A    + P      +  + EG  A   C V     G P     W      W   
Sbjct: 234 PADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYV----MGKPEPEIEWH-----WEGR 284

Query: 755 PL---------------ETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRP 799
           PL                 + +L     D  LY C     AG  LS  V L V  P  R 
Sbjct: 285 PLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSA-VQLHVKEP--RL 341

Query: 800 KLSALLDMGQGH---MALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEA 856
           + +  L   +G    +A+  C V +  +        + LL            +++   E 
Sbjct: 342 RFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCR---------KYEQIEEG 392

Query: 857 NSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSP-ELQEGQAVVLS 915
              +L +  L   D G Y CE   + G   T     V+G  ++  P   ++ EG+  VL 
Sbjct: 393 TVRRLIIHRLKADDDGIYLCE---MRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLL 449

Query: 916 CQVHTGVPEGTSYRWYRDGQPL 937
            +    +  G   RW RDG+ L
Sbjct: 450 VET---LEAGVEGRWSRDGEEL 468



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 146/666 (21%), Positives = 232/666 (34%), Gaps = 127/666 (19%)

Query: 898  VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYR---------------WYRDGQPLQESTS 942
            VQ S +  +QE    +LS Q    +   TS R               WY+DGQ ++ES  
Sbjct: 702  VQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESEL 761

Query: 943  ATLR---------FAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLM 993
              ++              +  +G + C+ +   +          +H+     HV +  + 
Sbjct: 762  LVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAI- 820

Query: 994  DTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLE 1053
                    +L C VD +  A +R     + V  +   V   EG   RL   V P T    
Sbjct: 821  ---TSECVMLACEVDRE-DAPVRWYKDGQEVEESDFVVLENEGPHRRL---VLPAT---- 869

Query: 1054 IHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVW---PG-----ATVREGQLVNL 1105
                   D G + C A +        A F     +V  W   P      A VR  ++V L
Sbjct: 870  ----QPSDGGEFQCVAGD------ECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVV-L 918

Query: 1106 TCLV---WTTHPAQLTYTWYQDGQQRLDA-----------HSIPLPNVTVRDATSYRCGV 1151
            TC +   W          W +DG++ +++             + LP V + D+  Y C +
Sbjct: 919  TCELCRPWA------EVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEI 972

Query: 1152 GPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVD--------SRPPAQL 1203
                     S   T+ V   P  +R+ Y  +    ++ L+  T++        SR  A +
Sbjct: 973  DDE------SASFTVTVTEPP--VRIIYPRD----EVTLIAVTLECVVLMCELSREDAPV 1020

Query: 1204 ALSHAGRLLASSTAASVPN---TLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG 1260
                 G  +  S A  +       RL L   QP D G + C A         ++    E 
Sbjct: 1021 RWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPER 1080

Query: 1261 VRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQ---------EGPAASLSF 1311
            +    A    +  GAP  V      A A +   WY +G  ++         EGP  +L+ 
Sbjct: 1081 IVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTL 1140

Query: 1312 LVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDS 1371
              A    AG Y C+ +    T +   A   V +   +   S    +    + V+ C + S
Sbjct: 1141 PHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPV-VLSCEL-S 1198

Query: 1372 EPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLL 1431
               A +  SH+G+ +    G+        H +  R  L +Q    PA    Y C +    
Sbjct: 1199 RAGAPVVWSHNGRPVQEGEGLEL------HAEGPRRVLCIQAAG-PAHAGLYTCQSGAAP 1251

Query: 1432 GSISTIGRLQV--EGARVVAEPGLDV----PEGAALNLSCRLLGGPGPVGNSTFAWFWND 1485
            G+ S    +QV     RVVA            G  L L   L G  GPV      W+ + 
Sbjct: 1252 GAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPV-----RWYKDG 1306

Query: 1486 RRLHAE 1491
             RL ++
Sbjct: 1307 ERLASQ 1312



 Score = 37.0 bits (84), Expect = 0.16
 Identities = 75/352 (21%), Positives = 116/352 (32%), Gaps = 89/352 (25%)

Query: 683 EEGLYLCEASNALGNASTSATFN-------------------------GQATVLAIAPSH 717
           + G+Y+C A NA G A  +A                            G    L    S 
Sbjct: 78  DAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQ 137

Query: 718 TLQEGTEANLTCNVSREAAGSPA-NFSWFRNGV----LW------------AQGPLETVT 760
            +  G E  LTC     A G P     W ++G+    +W              GP  ++ 
Sbjct: 138 WVLRGAEVVLTCR----AGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLA 193

Query: 761 L--LPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSA--------------- 803
           L  L     D+ +Y C      G       LL V  PP+ P                   
Sbjct: 194 LRILAARLPDSGVYVCHARNAHG-HAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAP 252

Query: 804 -LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLE 862
               + +G  A F C V  +P   +  +H E        P +P   R   +       L+
Sbjct: 253 KTFWVNEGKHAKFRCYVMGKPEPEIE-WHWEGR------PLLPDRRRLMYRDRDGGFVLK 305

Query: 863 VRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQ---AVVLSCQV- 918
           V      D G Y C A N  G + +++   V+   ++ +   +  EG+     VL C+V 
Sbjct: 306 VLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVP 365

Query: 919 HTGVPEGTSYRWYRDGQPL---------QESTSATLRFAAITLTQAGAYHCQ 961
           ++ +P      W+R+ Q L         +E T   L    +     G Y C+
Sbjct: 366 NSRIPTA----WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCE 413



 Score = 35.0 bits (79), Expect = 0.63
 Identities = 31/106 (29%), Positives = 40/106 (37%), Gaps = 17/106 (16%)

Query: 1517 TGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASS 1576
            +G   S P  LR   P         V    G    L C V  EP   +    G + +A+S
Sbjct: 5    SGDQGSPPCFLRFPRP---------VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAAS 55

Query: 1577 QPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
            +    PA+   H L    AL        P+D G Y+C A N  G A
Sbjct: 56   ERLSFPADGAEHGLLLTAAL--------PTDAGVYVCRARNAAGEA 93



 Score = 31.6 bits (70), Expect = 6.9
 Identities = 69/292 (23%), Positives = 101/292 (34%), Gaps = 62/292 (21%)

Query: 100  LLLKDLQPEDSGSY--NFRFEISEVNRWSDVKGTLVTVTEEP----RVPTIASPVELLEG 153
            L L   QPED+G Y    R E    N         V + E P     + T  SP+ +  G
Sbjct: 1138 LTLPHAQPEDAGEYVCETRHEAITFN---------VILAEPPVQFLALETTPSPLCVAPG 1188

Query: 154  TEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGR 213
              V  +C       +    + W      R V    +  E    G    L +  +   H  
Sbjct: 1189 EPVVLSCELS----RAGAPVVWSHN--GRPVQ-EGEGLELHAEGPRRVLCIQAAGPAHAG 1241

Query: 214  ILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNIL---PGELVTLTCQVNSSYPA 270
            +  CQ   A         +QV   P  V+++   + +  +   PG  + L   V+ S P 
Sbjct: 1242 LYTCQSGAAPGAPSLSFTVQVAEPP--VRVVAPEAAQTRVRSTPGGDLELV--VHLSGPG 1297

Query: 271  VSSIKWLKDGVRLQTK----------TGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPIS 320
               ++W KDG RL ++            VL +  A   DAG Y C A          P  
Sbjct: 1298 -GPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDA----------PQD 1346

Query: 321  LHIFMAEVQ-------VSPAGPIL--ENQTVTLVCNTPNEAPSDLRYSWYKN 363
              IF+  V+       VS   P+   E    T  C     +P D   +W +N
Sbjct: 1347 SRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEV---SPPDADVTWLRN 1395


>gi|193794821 sialic acid binding Ig-like lectin 6 isoform 1
           precursor [Homo sapiens]
          Length = 453

 Score =  100 bits (248), Expect = 2e-20
 Identities = 96/357 (26%), Positives = 152/357 (42%), Gaps = 44/357 (12%)

Query: 4   LPKLL-LLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYD 62
           LP LL LL +   A +  + +  P+ +   +G C+L+PC         +P       Y+ 
Sbjct: 13  LPLLLPLLWAGALAQERRFQLEGPESLTVQEGLCVLVPCRLP----TTLPASYYGYGYWF 68

Query: 63  YSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEV 122
             G    V+ +   + V+   RGR   + +P  + C+L ++D +  D+ +Y FR +   +
Sbjct: 69  LEGADVPVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWM 128

Query: 123 NRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPAR 182
                     V V      P I+ P  L  G   +  CS P+VC Q        G  P  
Sbjct: 129 KYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQ--------GTPPI- 179

Query: 183 SVTFNSQKFEPTGVGHLETLHMAMSW----QDHGRILRCQLSV--ANHRAQSEIHLQVKY 236
              F+     PT +G   T    ++     QDH   L CQ++   A    +  I L V Y
Sbjct: 180 ---FSWMSAAPTSLGPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSY 236

Query: 237 APKGV------------KILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ 284
           AP+ V            KIL + S   +L G+ + L C  + + PA   + W +    L 
Sbjct: 237 APQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPA--HLSWFQGFPALN 294

Query: 285 ----TKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPIL 337
               + TGVL LPQ   ++ G +TC+A++ +GSL    ISL +F+       AG +L
Sbjct: 295 ATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSL---QISLSLFVHWKPEGRAGGVL 348



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 53/186 (28%), Positives = 73/186 (39%), Gaps = 26/186 (13%)

Query: 1093 PGATVREGQLVNLTCLV-WTTHPAQLT-YTWYQDGQQRLDAHSIPLPNVTVRD-----AT 1145
            PG T+  G   NLTC V W         ++W       L   +     +T+       +T
Sbjct: 153  PG-TLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSLGPRTTQSSVLTITPRPQDHST 211

Query: 1146 SYRCGVGPPGRAPRLSRPITLDVLYAPRNLRL---------------TYLLESHGGQLAL 1190
            +  C V  PG    + R I L+V YAP+ + +               T  L    GQ   
Sbjct: 212  NLTCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALR 271

Query: 1191 VLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQA 1250
            +LC  D  PPA L+       L    A  + NT  LEL      +EG ++C A+ PLG  
Sbjct: 272  LLCDADGNPPAHLSWFQGFPAL---NATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSL 328

Query: 1251 NTSLEL 1256
              SL L
Sbjct: 329  QISLSL 334



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 49/193 (25%), Positives = 78/193 (40%), Gaps = 36/193 (18%)

Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPLET----VTLLPVARTDAALY 772
           TL+ G  +NLTC+V      G+P  FSW  +    + GP  T    +T+ P  +  +   
Sbjct: 155 TLESGHPSNLTCSVPWVCEQGTPPIFSWM-SAAPTSLGPRTTQSSVLTITPRPQDHSTNL 213

Query: 773 ACRI-LTEAGAQLSTPVLLSVLYPPDRPKLSAL---------------LDMGQGHMALFI 816
            C++    AG  +   + L+V Y P +  +S                 L + +G     +
Sbjct: 214 TCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLL 273

Query: 817 CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRC 876
           C  D  P A L+ F G   L               A   +N+  LE+ ++G  + G + C
Sbjct: 274 CDADGNPPAHLSWFQGFPAL--------------NATPISNTGVLELPQVGSAEEGDFTC 319

Query: 877 EATNVLGSSNTSL 889
            A + LGS   SL
Sbjct: 320 RAQHPLGSLQISL 332



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 55/236 (23%), Positives = 84/236 (35%), Gaps = 62/236 (26%)

Query: 886  NTSLFFQVRGAWVQ--------------------VSPSPELQEGQAVVLSCQVHTGVPEG 925
            N + FF+++  W++                    +S    L+ G    L+C V     +G
Sbjct: 116  NAAYFFRLKSKWMKYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQG 175

Query: 926  TS--YRWYRDGQPLQESTSATLRFAAITLTQAGAYH-----CQAQAPGSATTSLAAPISL 978
            T   + W     P       T + + +T+T     H     CQ   PG+  T +   I L
Sbjct: 176  TPPIFSWM-SAAPTSLGPRTT-QSSVLTITPRPQDHSTNLTCQVTFPGAGVT-MERTIQL 232

Query: 979  HVSYAPRHVTL---------------TTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRL 1023
            +VSYAP+ V +               T+ +    G+   LLC  D +PPA L    G   
Sbjct: 233  NVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQG--- 289

Query: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASAS 1079
                           P L+     NT  LE+      +EG + C A + LG    S
Sbjct: 290  --------------FPALNATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQIS 331



 Score = 31.2 bits (69), Expect = 9.0
 Identities = 19/67 (28%), Positives = 32/67 (47%), Gaps = 5/67 (7%)

Query: 335 PILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLED---AHSHTLRLHLATRADTGFYFCE 391
           P+LE Q + L+C+     P+ L  SW++    L     +++  L L     A+ G + C 
Sbjct: 263 PVLEGQALRLLCDADGNPPAHL--SWFQGFPALNATPISNTGVLELPQVGSAEEGDFTCR 320

Query: 392 VQNVHGS 398
            Q+  GS
Sbjct: 321 AQHPLGS 327


>gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Homo
           sapiens]
          Length = 602

 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 114/450 (25%), Positives = 182/450 (40%), Gaps = 70/450 (15%)

Query: 5   PKLLLLASFFPAGQA-------SWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITA 57
           P++LLL    P   A       S+ +   + V   +G C+++ C  S+P D    D  TA
Sbjct: 11  PEMLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDGW--DESTA 68

Query: 58  IWYYDYSGQRQV-----VSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGS 112
            + Y + G+        V+ +   + VE   R R +  G+P    C+L+++D Q ED   
Sbjct: 69  AYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAW 128

Query: 113 YNFRFEISEVNRWSDVKGT-LVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQV 171
           Y FR E     R S +     + VT   + P +  P  L  G  V   C           
Sbjct: 129 YFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTVICV---------- 178

Query: 172 RLQWQGQD-PARSVTFNSQKFEP----TGVGHLETLHMAMSWQDHGRILRCQLSVANH-- 224
              W  +  PA S ++      P        H   L    S QDH   L C +  +    
Sbjct: 179 -FNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGV 237

Query: 225 RAQSEIHLQVKYAPKGVKILLSPSGRNIL------------PGELVTLTCQVNSSYPAVS 272
            AQ  + L+V YAPK + I +S    + L             G+ + L C  +S  PA  
Sbjct: 238 SAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPA-- 295

Query: 273 SIKW-LKDGVRLQT-----KTGVLHLPQAAWSDAGVYTCQAENGVG--------SLVSPP 318
           ++ W L+D V   +     +T  L L      D+G YTC+AEN +G        S+  PP
Sbjct: 296 TLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPP 355

Query: 319 ISLHIFMAEVQVS--------PAGPILENQTVTLVCNTPNEAPSDLRYS-WYKNHVLLED 369
            +L + +++   +         + P+LE Q++ LVC T +  P+ L ++ W +     + 
Sbjct: 356 ENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQP 415

Query: 370 AHSHTLRLHLATRADTGFYFCEVQNVHGSE 399
           +    L L        G + C  Q+  GS+
Sbjct: 416 SDPGVLELPPIQMEHEGEFTCHAQHPLGSQ 445



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 61/224 (27%), Positives = 93/224 (41%), Gaps = 37/224 (16%)

Query: 1145 TSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY---------------LLESHGGQLA 1189
            T   C V    +     R + L V YAP++L ++                 LE   GQ  
Sbjct: 224  TDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFL 283

Query: 1190 LVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQ 1249
             +LC  DS+PPA L+     R+L+SS     P TL LELRG +  D G Y+C A + LG 
Sbjct: 284  RLLCAADSQPPATLSWVLQDRVLSSSHPWG-PRTLGLELRGVRAGDSGRYTCRAENRLGS 342

Query: 1250 ANTSLELRL----EGVRVILA-------------PEAAVPEGAPITVTCADPAAHAPTLY 1292
               +L+L +    E +RV+++                 V EG  + + C   ++  P   
Sbjct: 343  QQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSS-PPARL 401

Query: 1293 TWYHNGRWL---QEGPAASLSFLVATRAHAGAYSCQAQDAQGTR 1333
            +W   G+ +   Q      L        H G ++C AQ   G++
Sbjct: 402  SWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQ 445



 Score = 65.1 bits (157), Expect = 6e-10
 Identities = 100/399 (25%), Positives = 148/399 (37%), Gaps = 92/399 (23%)

Query: 634 LQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYL--CEA 691
           +++  +DR   T  P  G CS                   + I +   E+E  Y    E 
Sbjct: 95  VEMSTRDRFQLTGDPGKGSCS-------------------LVIRDAQREDEAWYFFRVER 135

Query: 692 SNALGNASTSATFNGQATVLAIAPS----HTLQEGTEANLTCNVSREAAGSPA-NFSWFR 746
            + + ++  S  F  + T L   P      TL+ G    + C  +      PA +FSW  
Sbjct: 136 GSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSW-- 193

Query: 747 NGVLWAQGPLET---------VTLLPVARTDAALYACRI-LTEAGAQLSTPVLLSVLYPP 796
            G   A  P  T         ++  P  +       C +  +  G      V L V Y P
Sbjct: 194 TGA--ALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAP 251

Query: 797 -------DRPKLSAL--------LDMGQGHMALFICTVDSRPLALLALFHGEHLLATS-- 839
                       SAL        L++ +G     +C  DS+P A L+    + +L++S  
Sbjct: 252 KDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHP 311

Query: 840 LGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR----G 895
            GP+              +L LE+R +  GDSG Y C A N LGS   +L   V+     
Sbjct: 312 WGPR--------------TLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPEN 357

Query: 896 AWVQVS-------------PSPELQEGQAVVLSCQVHTGVPEGTSY-RWYRDGQPLQEST 941
             V VS              S  + EGQ++ L C  H+  P   S+ RW +   P Q S 
Sbjct: 358 LRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSD 417

Query: 942 SATLRFAAITLTQAGAYHCQAQAP-GSATTSLAAPISLH 979
              L    I +   G + C AQ P GS   SL+  +S+H
Sbjct: 418 PGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLS--LSVH 454



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 93/398 (23%), Positives = 148/398 (37%), Gaps = 78/398 (19%)

Query: 843  QVPSHGRFQAKAEAN--SLKLEVRELGLGDSGSY--RCEATNVLGSSNTSLFFQVRGAWV 898
            ++ +  RFQ   +    S  L +R+    D   Y  R E  + +  S  S  F ++   +
Sbjct: 96   EMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTAL 155

Query: 899  QVSPS---PE-LQEGQAVVLSCQVHTGVPE--GTSYRWYRDGQPLQESTSATLRFAAITL 952
               P    PE L+ GQ V + C  +    +    S+ W       + +  +T  F+ ++ 
Sbjct: 156  TKKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSF 215

Query: 953  TQAGAYH-----CQAQAPGSATTSLAAPISLHVSYAPRHVTLTT---------------L 992
            T +   H     C          S    + L V+YAP+ + ++                 
Sbjct: 216  TPSPQDHDTDLTCHVDFSRKGV-SAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIY 274

Query: 993  MDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRL 1052
            ++   G+   LLC  DS PPA L  +  DR+++S+      P G          P TL L
Sbjct: 275  LEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSS-----HPWG----------PRTLGL 319

Query: 1053 EIHGAMLEDEGVYICEASNTLGQASASADFDAQ-----------------AVNVQVWPGA 1095
            E+ G    D G Y C A N LG    + D   Q                   N+      
Sbjct: 320  ELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSL 379

Query: 1096 TVREGQLVNLTCLVWTTHPAQLTYT-WYQ--DGQQRLDAHSIPLPNVTVRDATSYRCGVG 1152
             V EGQ + L C+  ++ PA+L++T W Q     Q  D   + LP + +     + C   
Sbjct: 380  PVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQ 439

Query: 1153 PPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLAL 1190
             P           L   +   +L + + LE HGG L L
Sbjct: 440  HP-----------LGSQHVSLSLSVHWKLE-HGGGLGL 465



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 54/179 (30%), Positives = 74/179 (41%), Gaps = 33/179 (18%)

Query: 420 FLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIR 479
           +LE Q G    L C+  S+P ATL       +L+S           S   GP +L LE+R
Sbjct: 274 YLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSS-----------SHPWGPRTLGLELR 322

Query: 480 DLEETDSGEYKCSATNSLGNATSTLD----FHANAARLLISPA-------------AEVV 522
            +   DSG Y C A N LG+    LD    +     R+++S A               V+
Sbjct: 323 GVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVL 382

Query: 523 EGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSS---LLLPAASSTDAGSYHCRAR 578
           EGQ++ L C +  S  P AR SW   G  +     S    L LP       G + C A+
Sbjct: 383 EGQSLRLVCVTHSS--PPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQ 439



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 87/345 (25%), Positives = 128/345 (37%), Gaps = 67/345 (19%)

Query: 1226 LELRGPQPRDEG--FYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE----GAPITV 1279
            L +R  Q  DE   F+     S +  +  S    L+   +   P+  +PE    G P+TV
Sbjct: 116  LVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTV 175

Query: 1280 TC----ADPAAHAPTLYTWYHNGRWL---QEGPAAS----LSFLVATRAHAGAYSCQAQ- 1327
             C    A     AP+ ++W   G  L   +  P+ S    LSF  + + H    +C    
Sbjct: 176  ICVFNWAFKKCPAPS-FSW--TGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDF 232

Query: 1328 DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR---------------SMAVIQCTVDSE 1372
              +G  + R   L+V YAP+D ++S   D+ +                    + C  DS+
Sbjct: 233  SRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQ 292

Query: 1373 PPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLL 1431
            PPA L+     +VL++S   H     T         L L+++ V AGD   Y C A+N L
Sbjct: 293  PPATLSWVLQDRVLSSS---HPWGPRT---------LGLELRGVRAGDSGRYTCRAENRL 340

Query: 1432 GSISTIGRLQV----EGARVVAE-------------PGLDVPEGAALNLSCRLLGGPGPV 1474
            GS      L V    E  RV+                 L V EG +L L C     P P 
Sbjct: 341  GSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSP-PA 399

Query: 1475 GNSTFAWFWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGA 1519
              S   W              L    +     G + C A+ P G+
Sbjct: 400  RLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGS 444



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 51/182 (28%), Positives = 77/182 (42%), Gaps = 29/182 (15%)

Query: 1097 VREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH-------SIPLPNVTVRDATSYRC 1149
            V++GQ + L C   +  PA  T +W    +    +H        + L  V   D+  Y C
Sbjct: 277  VQKGQFLRLLCAADSQPPA--TLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTC 334

Query: 1150 GVGPPGRAPRLSRPITLDVLYAPRNLRLTY------LLESHG---------GQLALVLCT 1194
                  R     + + L V Y P NLR+        +LE+ G         GQ   ++C 
Sbjct: 335  RA--ENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCV 392

Query: 1195 VDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSL 1254
              S PPA+L+ +  G+ +  S  +  P  L  EL   Q   EG ++C A+ PLG  + SL
Sbjct: 393  THSSPPARLSWTRWGQTVGPSQPSD-PGVL--ELPPIQMEHEGEFTCHAQHPLGSQHVSL 449

Query: 1255 EL 1256
             L
Sbjct: 450  SL 451



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 36/119 (30%), Positives = 53/119 (44%), Gaps = 27/119 (22%)

Query: 1518 GAAASAPVMLRVLYPPKTPTM---------------MVFVEPEGGLRGILDCRVDSEPLA 1562
            G +A   V LRV Y PK   +               ++++E + G    L C  DS+P A
Sbjct: 236  GVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPA 295

Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621
            +L+  L  R+++SS P G            P  L +++  +R  D G Y C A N LGS
Sbjct: 296  TLSWVLQDRVLSSSHPWG------------PRTLGLELRGVRAGDSGRYTCRAENRLGS 342



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 89/372 (23%), Positives = 125/372 (33%), Gaps = 82/372 (22%)

Query: 464 RFSGTSGPNSLRLEIRDLEETDSGEY--KCSATNSLGNATSTLDFHANAARLLISPAAEV 521
           + +G  G  S  L IRD +  D   Y  +    + + ++  +  F      L   P   +
Sbjct: 104 QLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYI 163

Query: 522 VE----GQAVTLSC--RSGLSPTPDARFSWYLNGALL----------HEGPGSSLLLPAA 565
            E    GQ VT+ C         P   FSW   GA L          H    S    P  
Sbjct: 164 PETLEPGQPVTVICVFNWAFKKCPAPSFSW--TGAALSPRRTRPSTSHFSVLSFTPSPQD 221

Query: 566 SSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAA----------GAG 615
             TD   +   +R G SA        L V Y P+    +   D  +A             
Sbjct: 222 HDTDLTCHVDFSRKGVSAQ---RTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQ 278

Query: 616 AGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVE 675
            G+   LLC  DS PPA L  + +DRV+++S P G                  P  L +E
Sbjct: 279 KGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWG------------------PRTLGLE 320

Query: 676 IHNPLLEEEGLYLCEASNALGNASTSATFNGQ--------------ATVLAIAPSHT--- 718
           +      + G Y C A N LG+   +   + Q               TVL    + T   
Sbjct: 321 LRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLP 380

Query: 719 LQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQ--GPLE-----TVTLLPVARTDAAL 771
           + EG    L C      +  PA  SW R    W Q  GP +      + L P+       
Sbjct: 381 VLEGQSLRLVCVTH---SSPPARLSWTR----WGQTVGPSQPSDPGVLELPPIQMEHEGE 433

Query: 772 YACRILTEAGAQ 783
           + C      G+Q
Sbjct: 434 FTCHAQHPLGSQ 445



 Score = 38.1 bits (87), Expect = 0.074
 Identities = 50/198 (25%), Positives = 71/198 (35%), Gaps = 39/198 (19%)

Query: 1453 LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP-----VPTLAFTHVARAQAG 1507
            L+V +G  L L C     P     +T +W   DR L +          L    V    +G
Sbjct: 275  LEVQKGQFLRLLCAADSQPP----ATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSG 330

Query: 1508 MYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI---------------L 1552
             Y C AE   G+   A + L V YPP+   +MV       L  +               L
Sbjct: 331  RYTCRAENRLGSQQQA-LDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRL 389

Query: 1553 DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612
             C   S P A L+     + V  SQP            + P  L  ++  ++   +GE+ 
Sbjct: 390  VCVTHSSPPARLSWTRWGQTVGPSQP------------SDPGVL--ELPPIQMEHEGEFT 435

Query: 1613 CSASNVLGSASTSTYFGV 1630
            C A + LGS   S    V
Sbjct: 436  CHAQHPLGSQHVSLSLSV 453



 Score = 32.3 bits (72), Expect = 4.1
 Identities = 45/184 (24%), Positives = 71/184 (38%), Gaps = 36/184 (19%)

Query: 336 ILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHS---HTLRLHL--ATRADTGFYFC 390
           + + Q + L+C   ++ P+ L  SW     +L  +H     TL L L      D+G Y C
Sbjct: 277 VQKGQFLRLLCAADSQPPATL--SWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTC 334

Query: 391 EVQNVHGSERSGPVSVVVNHPP------LTPVLTAFLETQAGLVGI---------LHCSV 435
             +N  GS++   + + V +PP      ++      LE       +         L C  
Sbjct: 335 RAENRLGSQQQA-LDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVT 393

Query: 436 VSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATN 495
            S P A L  +  G     T G S   P   G        LE+  ++    GE+ C A +
Sbjct: 394 HSSPPARLSWTRWG----QTVGPS--QPSDPGV-------LELPPIQMEHEGEFTCHAQH 440

Query: 496 SLGN 499
            LG+
Sbjct: 441 PLGS 444


>gi|193794817 sialic acid binding Ig-like lectin 6 isoform 3
           precursor [Homo sapiens]
          Length = 353

 Score = 99.0 bits (245), Expect = 4e-20
 Identities = 93/345 (26%), Positives = 148/345 (42%), Gaps = 44/345 (12%)

Query: 4   LPKLL-LLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYD 62
           LP LL LL +   A +  + +  P+ +   +G C+L+PC         +P       Y+ 
Sbjct: 13  LPLLLPLLWAGALAQERRFQLEGPESLTVQEGLCVLVPCRLP----TTLPASYYGYGYWF 68

Query: 63  YSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEV 122
             G    V+ +   + V+   RGR   + +P  + C+L ++D +  D+ +Y FR +   +
Sbjct: 69  LEGADVPVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWM 128

Query: 123 NRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPAR 182
                     V V      P I+ P  L  G   +  CS P+VC Q        G  P  
Sbjct: 129 KYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQ--------GTPPI- 179

Query: 183 SVTFNSQKFEPTGVGHLETLHMAMSW----QDHGRILRCQLSV--ANHRAQSEIHLQVKY 236
              F+     PT +G   T    ++     QDH   L CQ++   A    +  I L V Y
Sbjct: 180 ---FSWMSAAPTSLGPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSY 236

Query: 237 APKGV------------KILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ 284
           AP+ V            KIL + S   +L G+ + L C  + + PA   + W +    L 
Sbjct: 237 APQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPA--HLSWFQGFPALN 294

Query: 285 ----TKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFM 325
               + TGVL LPQ   ++ G +TC+A++ +GSL    ISL +F+
Sbjct: 295 ATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSL---QISLSLFV 336



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 53/186 (28%), Positives = 73/186 (39%), Gaps = 26/186 (13%)

Query: 1093 PGATVREGQLVNLTCLV-WTTHPAQLT-YTWYQDGQQRLDAHSIPLPNVTVRD-----AT 1145
            PG T+  G   NLTC V W         ++W       L   +     +T+       +T
Sbjct: 153  PG-TLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSLGPRTTQSSVLTITPRPQDHST 211

Query: 1146 SYRCGVGPPGRAPRLSRPITLDVLYAPRNLRL---------------TYLLESHGGQLAL 1190
            +  C V  PG    + R I L+V YAP+ + +               T  L    GQ   
Sbjct: 212  NLTCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALR 271

Query: 1191 VLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQA 1250
            +LC  D  PPA L+       L    A  + NT  LEL      +EG ++C A+ PLG  
Sbjct: 272  LLCDADGNPPAHLSWFQGFPAL---NATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSL 328

Query: 1251 NTSLEL 1256
              SL L
Sbjct: 329  QISLSL 334



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 49/193 (25%), Positives = 78/193 (40%), Gaps = 36/193 (18%)

Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPLET----VTLLPVARTDAALY 772
           TL+ G  +NLTC+V      G+P  FSW  +    + GP  T    +T+ P  +  +   
Sbjct: 155 TLESGHPSNLTCSVPWVCEQGTPPIFSWM-SAAPTSLGPRTTQSSVLTITPRPQDHSTNL 213

Query: 773 ACRI-LTEAGAQLSTPVLLSVLYPPDRPKLSAL---------------LDMGQGHMALFI 816
            C++    AG  +   + L+V Y P +  +S                 L + +G     +
Sbjct: 214 TCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLL 273

Query: 817 CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRC 876
           C  D  P A L+ F G   L               A   +N+  LE+ ++G  + G + C
Sbjct: 274 CDADGNPPAHLSWFQGFPAL--------------NATPISNTGVLELPQVGSAEEGDFTC 319

Query: 877 EATNVLGSSNTSL 889
            A + LGS   SL
Sbjct: 320 RAQHPLGSLQISL 332



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 55/236 (23%), Positives = 84/236 (35%), Gaps = 62/236 (26%)

Query: 886  NTSLFFQVRGAWVQ--------------------VSPSPELQEGQAVVLSCQVHTGVPEG 925
            N + FF+++  W++                    +S    L+ G    L+C V     +G
Sbjct: 116  NAAYFFRLKSKWMKYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQG 175

Query: 926  TS--YRWYRDGQPLQESTSATLRFAAITLTQAGAYH-----CQAQAPGSATTSLAAPISL 978
            T   + W     P       T + + +T+T     H     CQ   PG+  T +   I L
Sbjct: 176  TPPIFSWM-SAAPTSLGPRTT-QSSVLTITPRPQDHSTNLTCQVTFPGAGVT-MERTIQL 232

Query: 979  HVSYAPRHVTL---------------TTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRL 1023
            +VSYAP+ V +               T+ +    G+   LLC  D +PPA L    G   
Sbjct: 233  NVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQG--- 289

Query: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASAS 1079
                           P L+     NT  LE+      +EG + C A + LG    S
Sbjct: 290  --------------FPALNATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQIS 331



 Score = 31.2 bits (69), Expect = 9.0
 Identities = 19/67 (28%), Positives = 32/67 (47%), Gaps = 5/67 (7%)

Query: 335 PILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLED---AHSHTLRLHLATRADTGFYFCE 391
           P+LE Q + L+C+     P+ L  SW++    L     +++  L L     A+ G + C 
Sbjct: 263 PVLEGQALRLLCDADGNPPAHL--SWFQGFPALNATPISNTGVLELPQVGSAEEGDFTCR 320

Query: 392 VQNVHGS 398
            Q+  GS
Sbjct: 321 AQHPLGS 327


>gi|193794819 sialic acid binding Ig-like lectin 6 isoform 2
           precursor [Homo sapiens]
          Length = 437

 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 90/343 (26%), Positives = 147/343 (42%), Gaps = 32/343 (9%)

Query: 4   LPKLL-LLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYD 62
           LP LL LL +   A +  + +  P+ +   +G C+L+PC         +P       Y+ 
Sbjct: 13  LPLLLPLLWAGALAQERRFQLEGPESLTVQEGLCVLVPCRLP----TTLPASYYGYGYWF 68

Query: 63  YSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEV 122
             G    V+ +   + V+   RGR   + +P  + C+L ++D +  D+ +Y FR +   +
Sbjct: 69  LEGADVPVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWM 128

Query: 123 NRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPAR 182
                     V V      P I+ P  L  G   +  CS P+VC Q        G  P  
Sbjct: 129 KYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQ--------GTPPI- 179

Query: 183 SVTFNSQKFEPTGVGHLETLHMAMSW----QDHGRILRCQLSVANHRAQSEIHLQVKYAP 238
              F+     PT +G   T    ++     QDH   L CQ++        E  +Q+  + 
Sbjct: 180 ---FSWMSAAPTSLGPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVS- 235

Query: 239 KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ----TKTGVLHLPQ 294
              KIL + S   +L G+ + L C  + + PA   + W +    L     + TGVL LPQ
Sbjct: 236 -SFKILQNTSSLPVLEGQALRLLCDADGNPPA--HLSWFQGFPALNATPISNTGVLELPQ 292

Query: 295 AAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPIL 337
              ++ G +TC+A++ +GSL    ISL +F+       AG +L
Sbjct: 293 VGSAEEGDFTCRAQHPLGSL---QISLSLFVHWKPEGRAGGVL 332



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 51/171 (29%), Positives = 71/171 (41%), Gaps = 12/171 (7%)

Query: 1093 PGATVREGQLVNLTCLV-WTTHPAQLT-YTWYQDGQQRLDAHSIPLPNVTVRD-----AT 1145
            PG T+  G   NLTC V W         ++W       L   +     +T+       +T
Sbjct: 153  PG-TLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSLGPRTTQSSVLTITPRPQDHST 211

Query: 1146 SYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLAL 1205
            +  C V  PG    + R I L+V  + + L+ T  L    GQ   +LC  D  PPA L+ 
Sbjct: 212  NLTCQVTFPGAGVTMERTIQLNVS-SFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSW 270

Query: 1206 SHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLEL 1256
                  L    A  + NT  LEL      +EG ++C A+ PLG    SL L
Sbjct: 271  FQGFPAL---NATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQISLSL 318



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 47/178 (26%), Positives = 75/178 (42%), Gaps = 22/178 (12%)

Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPLET----VTLLPVARTDAALY 772
           TL+ G  +NLTC+V      G+P  FSW  +    + GP  T    +T+ P  +  +   
Sbjct: 155 TLESGHPSNLTCSVPWVCEQGTPPIFSWM-SAAPTSLGPRTTQSSVLTITPRPQDHSTNL 213

Query: 773 ACRI-LTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFH 831
            C++    AG  +   + L+V         S+L  + +G     +C  D  P A L+ F 
Sbjct: 214 TCQVTFPGAGVTMERTIQLNVSSFKILQNTSSLPVL-EGQALRLLCDADGNPPAHLSWFQ 272

Query: 832 GEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSL 889
           G   L               A   +N+  LE+ ++G  + G + C A + LGS   SL
Sbjct: 273 GFPAL--------------NATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQISL 316



 Score = 38.9 bits (89), Expect = 0.043
 Identities = 51/221 (23%), Positives = 81/221 (36%), Gaps = 48/221 (21%)

Query: 886  NTSLFFQVRGAWVQ--------------------VSPSPELQEGQAVVLSCQVHTGVPEG 925
            N + FF+++  W++                    +S    L+ G    L+C V     +G
Sbjct: 116  NAAYFFRLKSKWMKYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQG 175

Query: 926  TS--YRWYRDGQPLQESTSATLRFAAITLTQAGAYH-----CQAQAPGSATTSLAAPISL 978
            T   + W     P       T + + +T+T     H     CQ   PG+  T +   I L
Sbjct: 176  TPPIFSWM-SAAPTSLGPRTT-QSSVLTITPRPQDHSTNLTCQVTFPGAGVT-MERTIQL 232

Query: 979  HVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSS 1038
            +VS + + +  T+ +    G+   LLC  D +PPA L    G                  
Sbjct: 233  NVS-SFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQG-----------------F 274

Query: 1039 PRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASAS 1079
            P L+     NT  LE+      +EG + C A + LG    S
Sbjct: 275  PALNATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQIS 315



 Score = 35.8 bits (81), Expect = 0.37
 Identities = 30/119 (25%), Positives = 54/119 (45%), Gaps = 7/119 (5%)

Query: 285 TKTGVLHLPQAAWSDAGVYTCQAE-NGVGSLVSPPISLHIFMAEV-QVSPAGPILENQTV 342
           T++ VL +       +   TCQ    G G  +   I L++   ++ Q + + P+LE Q +
Sbjct: 195 TQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSSFKILQNTSSLPVLEGQAL 254

Query: 343 TLVCNTPNEAPSDLRYSWYKNHVLLED---AHSHTLRLHLATRADTGFYFCEVQNVHGS 398
            L+C+     P+ L  SW++    L     +++  L L     A+ G + C  Q+  GS
Sbjct: 255 RLLCDADGNPPAHL--SWFQGFPALNATPISNTGVLELPQVGSAEEGDFTCRAQHPLGS 311


>gi|23943856 sialic acid binding Ig-like lectin 9 [Homo sapiens]
          Length = 463

 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 89/323 (27%), Positives = 135/323 (41%), Gaps = 37/323 (11%)

Query: 17  GQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSG----QRQVVSH 72
           GQ S  ++    V   +G C+ +PC FS+P+   +  G     Y+   G    Q   V+ 
Sbjct: 17  GQTSKLLTMQSSVTVQEGLCVHVPCSFSYPSHGWIYPGPVVHGYWFREGANTDQDAPVAT 76

Query: 73  SADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTL 132
           +   + V    R R   +G+P  + C L ++D +  D+G Y FR E   + +W+     L
Sbjct: 77  NNPARAVWEETRDRFHLLGDPHTKNCTLSIRDARRSDAGRYFFRMEKGSI-KWNYKHHRL 135

Query: 133 -VTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKF 191
            V VT     P I  P  L  G   +  CS P+ C         QG  P  S    S   
Sbjct: 136 SVNVTALTHRPNILIPGTLESGCPQNLTCSVPWAC--------EQGTPPMISWIGTSVSP 187

Query: 192 EPTGVGHLETLHMAMSWQDHGRILRCQLSV--ANHRAQSEIHLQVKYAPKGV-------- 241
                     L +    QDHG  L CQ++   A+      +HL V Y P+ +        
Sbjct: 188 LDPSTTRSSVLTLIPQPQDHGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGD 247

Query: 242 ----KILLSPSGRNILPGELVTLTC---QVNSSYPAVSSIKWLKDGVRL----QTKTGVL 290
                +L + S  ++  G+ + L C    V+S+ PA  S+ W   G+ L     +  GVL
Sbjct: 248 GTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSLSW--RGLTLCPSQPSNPGVL 305

Query: 291 HLPQAAWSDAGVYTCQAENGVGS 313
            LP     DA  +TC+A+N +GS
Sbjct: 306 ELPWVHLRDAAEFTCRAQNPLGS 328



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 72/263 (27%), Positives = 98/263 (37%), Gaps = 47/263 (17%)

Query: 1035 EGSSPRLHVAVAPNTLR--LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVW 1092
            E +  R H+   P+T    L I  A   D G Y        G    +      +VNV   
Sbjct: 85   EETRDRFHLLGDPHTKNCTLSIRDARRSDAGRYFFRMEK--GSIKWNYKHHRLSVNVTAL 142

Query: 1093 --------PGATVREGQLVNLTCLV-WTTHPAQLTY-TWYQDGQQRLDAHS--------I 1134
                    PG T+  G   NLTC V W          +W       LD  +        I
Sbjct: 143  THRPNILIPG-TLESGCPQNLTCSVPWACEQGTPPMISWIGTSVSPLDPSTTRSSVLTLI 201

Query: 1135 PLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY--------------- 1179
            P P       TS  C V  PG +   ++ + L+V Y P+NL +T                
Sbjct: 202  PQPQ---DHGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGS 258

Query: 1180 ---LLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDE 1236
               L E    +L   +  VDS PPA+L+LS  G  L  S  +   N   LEL     RD 
Sbjct: 259  SLSLPEGQSLRLVCAVDAVDSNPPARLSLSWRGLTLCPSQPS---NPGVLELPWVHLRDA 315

Query: 1237 GFYSCSARSPLGQANTSLELRLE 1259
              ++C A++PLG     L + L+
Sbjct: 316  AEFTCRAQNPLGSQQVYLNVSLQ 338



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 55/200 (27%), Positives = 78/200 (39%), Gaps = 47/200 (23%)

Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPLE-------TVTLLPVARTDA 769
           TL+ G   NLTC+V      G+P   SW    V     PL+        +TL+P  +   
Sbjct: 153 TLESGCPQNLTCSVPWACEQGTPPMISWIGTSV----SPLDPSTTRSSVLTLIPQPQDHG 208

Query: 770 ALYACRILTEAGAQLST--PVLLSVLYPPDRPKLSAL---------------LDMGQGHM 812
               C++ T  GA ++T   V L+V YPP    ++                 L + +G  
Sbjct: 209 TSLTCQV-TFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQS 267

Query: 813 ALFICTVD---SRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869
              +C VD   S P A L+L         +L P  PS          N   LE+  + L 
Sbjct: 268 LRLVCAVDAVDSNPPARLSL----SWRGLTLCPSQPS----------NPGVLELPWVHLR 313

Query: 870 DSGSYRCEATNVLGSSNTSL 889
           D+  + C A N LGS    L
Sbjct: 314 DAAEFTCRAQNPLGSQQVYL 333



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 52/205 (25%), Positives = 79/205 (38%), Gaps = 43/205 (20%)

Query: 906  LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYH-----C 960
            L+ G    L+C V     +GT       G  +     +T R + +TL      H     C
Sbjct: 154  LESGCPQNLTCSVPWACEQGTPPMISWIGTSVSPLDPSTTRSSVLTLIPQPQDHGTSLTC 213

Query: 961  QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTG---------------PGRLGLLLC 1005
            Q   PG++ T+    + L+VSY P+++T+T     G                G+   L+C
Sbjct: 214  QVTFPGASVTTNKT-VHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVC 272

Query: 1006 ---RVDSDPPAQLRL-LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061
                VDS+PPA+L L   G  L  S        + S+P +          LE+    L D
Sbjct: 273  AVDAVDSNPPARLSLSWRGLTLCPS--------QPSNPGV----------LELPWVHLRD 314

Query: 1062 EGVYICEASNTLGQASASADFDAQA 1086
               + C A N LG      +   Q+
Sbjct: 315  AAEFTCRAQNPLGSQQVYLNVSLQS 339



 Score = 33.5 bits (75), Expect = 1.8
 Identities = 48/195 (24%), Positives = 73/195 (37%), Gaps = 39/195 (20%)

Query: 1264 ILAPEAAVPEGAPITVTCADPAA---HAPTLYTWYHNG-RWLQEGPAAS--LSFLVATRA 1317
            IL P   +  G P  +TC+ P A     P + +W       L      S  L+ +   + 
Sbjct: 148  ILIP-GTLESGCPQNLTCSVPWACEQGTPPMISWIGTSVSPLDPSTTRSSVLTLIPQPQD 206

Query: 1318 HAGAYSCQAQ-DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV------------ 1364
            H  + +CQ         +++   L V Y PQ+  ++ F+     S  +            
Sbjct: 207  HGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQ 266

Query: 1365 ---IQCTVD---SEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPA 1418
               + C VD   S PPA L+LS  G  L  S       S  G +++    LR   +    
Sbjct: 267  SLRLVCAVDAVDSNPPARLSLSWRGLTLCPSQ-----PSNPGVLELPWVHLRDAAE---- 317

Query: 1419 GDDTYVCTAQNLLGS 1433
                + C AQN LGS
Sbjct: 318  ----FTCRAQNPLGS 328



 Score = 32.0 bits (71), Expect = 5.3
 Identities = 37/115 (32%), Positives = 45/115 (39%), Gaps = 32/115 (27%)

Query: 1525 VMLRVLYPPKTPTMMVFVE----------------PEG-GLRGILDC-RVDSEPLASLTL 1566
            V L V YPP+  TM VF                  PEG  LR +     VDS P A L+L
Sbjct: 228  VHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSL 287

Query: 1567 HLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621
                  +  SQP            ++P  L +    LR  D  E+ C A N LGS
Sbjct: 288  SWRGLTLCPSQP------------SNPGVLELPWVHLR--DAAEFTCRAQNPLGS 328


>gi|94538343 sialic acid binding Ig-like lectin 8 [Homo sapiens]
          Length = 499

 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 103/401 (25%), Positives = 163/401 (40%), Gaps = 48/401 (11%)

Query: 33  KGSCLLIPCIFSFPADVEVP-DGITAIWYY--DYSGQRQVVSHSADPKLVEARFRGRTEF 89
           +G C+ +PC FS+P D     D +   W+   D   Q   V+ +   + V+A  +GR + 
Sbjct: 39  EGLCVHVPCSFSYPQDGWTDSDPVHGYWFRAGDRPYQDAPVATNNPDREVQAETQGRFQL 98

Query: 90  MGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWS-------DVKGTLVTVTEEPRVP 142
           +G+     C+L ++D +  D GSY FR E   + +WS         K   V VT     P
Sbjct: 99  LGDIWSNDCSLSIRDARKRDKGSYFFRLERGSM-KWSYKSQLNYKTKQLSVFVTALTHRP 157

Query: 143 TIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETL 202
            I     L  G   +  CS P+ C         QG  P  S    S             L
Sbjct: 158 DILILGTLESGHSRNLTCSVPWACK--------QGTPPMISWIGASVSSPGPTTARSSVL 209

Query: 203 HMAMSWQDHGRILRCQLSV--ANHRAQSEIHLQVKYAPKGVKI------------LLSPS 248
            +    QDHG  L CQ+++        S + L V Y P  + +            L + S
Sbjct: 210 TLTPKPQDHGTSLTCQVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGS 269

Query: 249 GRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRL----QTKTGVLHLPQAAWSDAGVYT 304
             ++L G+ + L C VNS+ PA   + W +  + L     +  G+L LP+    D G +T
Sbjct: 270 SLSVLEGQSLRLVCAVNSNPPA--RLSWTRGSLTLCPSRSSNPGLLELPRVHVRDEGEFT 327

Query: 305 CQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNH 364
           C+A+N  G   S  ISL + +       + P+ +   VTL       A +    S+    
Sbjct: 328 CRAQNAQG---SQHISLSLSLQNEGTGTSRPVSQ---VTLAAVGGAGATALAFLSFCIIF 381

Query: 365 VLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVS 405
           +++      + R   A   DTG    + + + GS   GP++
Sbjct: 382 IIVRSCRKKSAR-PAAGVGDTGME--DAKAIRGSASQGPLT 419



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 68/276 (24%), Positives = 104/276 (37%), Gaps = 51/276 (18%)

Query: 843  QVPSHGRFQAKAE--ANSLKLEVRELGLGDSGSY--RCEATNVLGSSNTSLFFQVRGAWV 898
            Q  + GRFQ   +  +N   L +R+    D GSY  R E  ++  S  + L ++ +   V
Sbjct: 89   QAETQGRFQLLGDIWSNDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTKQLSV 148

Query: 899  QVSPSPE---------LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAA 949
             V+             L+ G +  L+C V     +GT       G  +      T R + 
Sbjct: 149  FVTALTHRPDILILGTLESGHSRNLTCSVPWACKQGTPPMISWIGASVSSPGPTTARSSV 208

Query: 950  ITLTQAGAYH-----CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL-- 1002
            +TLT     H     CQ   PG+  T+ +  + L VSY P ++T+T           L  
Sbjct: 209  LTLTPKPQDHGTSLTCQVTLPGTGVTTTST-VRLDVSYPPWNLTMTVFQGDATASTALGN 267

Query: 1003 -------------LLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNT 1049
                         L+C V+S+PPA+L    G   +  +         S+P L        
Sbjct: 268  GSSLSVLEGQSLRLVCAVNSNPPARLSWTRGSLTLCPS-------RSSNPGL-------- 312

Query: 1050 LRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQ 1085
              LE+    + DEG + C A N  G    S     Q
Sbjct: 313  --LELPRVHVRDEGEFTCRAQNAQGSQHISLSLSLQ 346



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 62/245 (25%), Positives = 93/245 (37%), Gaps = 36/245 (14%)

Query: 1048 NTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGA-----------T 1096
            N   L I  A   D+G Y         + S  +  + +   + V+  A           T
Sbjct: 105  NDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGT 164

Query: 1097 VREGQLVNLTCLV-WTTH---PAQLTY---TWYQDGQQRLDAHSIPLPNVTVRDATSYRC 1149
            +  G   NLTC V W      P  +++   +    G     +  + L        TS  C
Sbjct: 165  LESGHSRNLTCSVPWACKQGTPPMISWIGASVSSPGPTTARSSVLTLTPKPQDHGTSLTC 224

Query: 1150 GVGPPGRAPRLSRPITLDVLYAPRNLRLTYL---------------LESHGGQLALVLCT 1194
             V  PG     +  + LDV Y P NL +T                 L    GQ   ++C 
Sbjct: 225  QVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVCA 284

Query: 1195 VDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSL 1254
            V+S PPA+L+ +     L  S ++   N   LEL     RDEG ++C A++  G  + SL
Sbjct: 285  VNSNPPARLSWTRGSLTLCPSRSS---NPGLLELPRVHVRDEGEFTCRAQNAQGSQHISL 341

Query: 1255 ELRLE 1259
             L L+
Sbjct: 342  SLSLQ 346



 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 53/193 (27%), Positives = 75/193 (38%), Gaps = 36/193 (18%)

Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPL----ETVTLLPVARTDAALY 772
           TL+ G   NLTC+V      G+P   SW    V  + GP       +TL P  +      
Sbjct: 164 TLESGHSRNLTCSVPWACKQGTPPMISWIGASVS-SPGPTTARSSVLTLTPKPQDHGTSL 222

Query: 773 ACRI-LTEAGAQLSTPVLLSVLYPP----------DRPKLSAL-----LDMGQGHMALFI 816
            C++ L   G   ++ V L V YPP          D    +AL     L + +G     +
Sbjct: 223 TCQVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLV 282

Query: 817 CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRC 876
           C V+S P A L+   G   L  S                +N   LE+  + + D G + C
Sbjct: 283 CAVNSNPPARLSWTRGSLTLCPS--------------RSSNPGLLELPRVHVRDEGEFTC 328

Query: 877 EATNVLGSSNTSL 889
            A N  GS + SL
Sbjct: 329 RAQNAQGSQHISL 341



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 67/268 (25%), Positives = 94/268 (35%), Gaps = 58/268 (21%)

Query: 472 NSLRLEIRDLEETDSGEY---------KCSATNSLGNATSTLDFHANAAR----LLISPA 518
           N   L IRD  + D G Y         K S  + L   T  L     A      +LI   
Sbjct: 105 NDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGT 164

Query: 519 AEVVEGQAVTLS----CRSGLSPTPDARFSWYLNGALLHEGPG---SSLLLPAASSTDAG 571
            E    + +T S    C+ G  P      SW +  ++   GP    SS+L       D G
Sbjct: 165 LESGHSRNLTCSVPWACKQGTPPM----ISW-IGASVSSPGPTTARSSVLTLTPKPQDHG 219

Query: 572 -SYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGA-----------GRR 619
            S  C+     +    +S   L V YPP   T T     DA  + A           G+ 
Sbjct: 220 TSLTCQVTLPGTGVTTTSTVRLDVSYPPWNLTMTV-FQGDATASTALGNGSSLSVLEGQS 278

Query: 620 GLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNP 679
             L+C V+S+PPARL        +  S  S  G                     +E+   
Sbjct: 279 LRLVCAVNSNPPARLSWTRGSLTLCPSRSSNPGL--------------------LELPRV 318

Query: 680 LLEEEGLYLCEASNALGNASTSATFNGQ 707
            + +EG + C A NA G+   S + + Q
Sbjct: 319 HVRDEGEFTCRAQNAQGSQHISLSLSLQ 346



 Score = 38.5 bits (88), Expect = 0.057
 Identities = 37/131 (28%), Positives = 51/131 (38%), Gaps = 30/131 (22%)

Query: 1511 CLAELP-TGAAASAPVMLRVLYPPKTPTMMVF--------VEPEGGLRGILD-------C 1554
            C   LP TG   ++ V L V YPP   TM VF            G    +L+       C
Sbjct: 224  CQVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVC 283

Query: 1555 RVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICS 1614
             V+S P A L+   GS  +  S+              S N   +++  +   D+GE+ C 
Sbjct: 284  AVNSNPPARLSWTRGSLTLCPSR--------------SSNPGLLELPRVHVRDEGEFTCR 329

Query: 1615 ASNVLGSASTS 1625
            A N  GS   S
Sbjct: 330  AQNAQGSQHIS 340



 Score = 37.4 bits (85), Expect = 0.13
 Identities = 64/277 (23%), Positives = 105/277 (37%), Gaps = 53/277 (19%)

Query: 1222 NTLRLELRGPQPRDEGFY---------SCSARSPLGQANTSLELRLEGV--RVILAPEAA 1270
            N   L +R  + RD+G Y           S +S L      L + +  +  R  +     
Sbjct: 105  NDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGT 164

Query: 1271 VPEGAPITVTCADPAA---HAPTLYTWYHNGRWLQEGPAASLSFLVAT----RAHAGAYS 1323
            +  G    +TC+ P A     P + +W         GP  + S ++      + H  + +
Sbjct: 165  LESGHSRNLTCSVPWACKQGTPPMISWI-GASVSSPGPTTARSSVLTLTPKPQDHGTSLT 223

Query: 1324 CQAQ-DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV---------------IQC 1367
            CQ      G  ++    L V Y P +  ++ F+     S A+               + C
Sbjct: 224  CQVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVC 283

Query: 1368 TVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTA 1427
             V+S PPA L+ +     L  S      +S  G +++     R+ V+D    +  + C A
Sbjct: 284  AVNSNPPARLSWTRGSLTLCPSR-----SSNPGLLELP----RVHVRD----EGEFTCRA 330

Query: 1428 QNLLGS--ISTIGRLQVEG---ARVVAEPGLDVPEGA 1459
            QN  GS  IS    LQ EG   +R V++  L    GA
Sbjct: 331  QNAQGSQHISLSLSLQNEGTGTSRPVSQVTLAAVGGA 367


>gi|16506826 sialic acid binding immunoglobulin-like lectin-like
           protein 1 isoform b precursor [Homo sapiens]
          Length = 477

 Score = 95.5 bits (236), Expect = 4e-19
 Identities = 82/310 (26%), Positives = 135/310 (43%), Gaps = 33/310 (10%)

Query: 26  PQDVQGVKGSCLLIPCIFSFPA-DVEVPDGITAIWYY---DYSGQRQVVSHSADPKLVEA 81
           P+ V   +G C+ +PC   +P  +      +   W+    D      V +++   K+ E 
Sbjct: 38  PESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQED 97

Query: 82  RFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTL-VTVTEEPR 140
              GR   +G+P+   C+L ++D +  DSG Y F+ E     +W+ +   L V VT    
Sbjct: 98  T-HGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGS-RKWNYIYDKLSVHVTALTH 155

Query: 141 VPTIASPVELLEGTEVDFNCSTPYVCLQ-EQVRLQWQGQDPARSVTFNSQKFEPTGVGHL 199
           +PT + P  L  G   +  CS P+ C Q     + W G         +    +PT +   
Sbjct: 156 MPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGA--------SVSSLDPT-ITRS 206

Query: 200 ETLHMAMSWQDHGRILRCQLSV--ANHRAQSEIHLQVKYAPKGVKI------------LL 245
             L +    QDHG  L CQ+++  A       + L + Y P+ + +            L 
Sbjct: 207 SMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLR 266

Query: 246 SPSGRNILPGELVTLTCQVNSSYPAVSSIKW--LKDGVRLQTKTGVLHLPQAAWSDAGVY 303
           + S  ++L G+ + L C V+S+ PA  S  W  L       +  GVL LP+    D G +
Sbjct: 267 NGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEF 326

Query: 304 TCQAENGVGS 313
           TC+A+N +GS
Sbjct: 327 TCRAQNPLGS 336



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 71/245 (28%), Positives = 99/245 (40%), Gaps = 42/245 (17%)

Query: 1048 NTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVW--------PGATVRE 1099
            N   L I  A   D G Y  +     G    +  +D  +V+V           PG T+  
Sbjct: 111  NNCSLSIRDARKGDSGKYYFQVER--GSRKWNYIYDKLSVHVTALTHMPTFSIPG-TLES 167

Query: 1100 GQLVNLTCLV-WTTHPAQL-TYTWYQDGQQRLDA--------HSIPLPNVTVRDATSYRC 1149
            G   NLTC V W        T TW       LD           IP P       TS  C
Sbjct: 168  GHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQ---DHGTSLTC 224

Query: 1150 GVGPPGRAPRLSRPITLDVLYAPRNLRLTYL---------------LESHGGQLALVLCT 1194
             V  PG    ++R + L++ Y P+NL +T                 L    GQ   ++C 
Sbjct: 225  QVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCA 284

Query: 1195 VDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSL 1254
            VDS PPA+L+ +     L+ S ++   N   LEL     +DEG ++C A++PLG  + SL
Sbjct: 285  VDSNPPARLSWTWGSLTLSPSQSS---NLGVLELPRVHVKDEGEFTCRAQNPLGSQHISL 341

Query: 1255 ELRLE 1259
             L L+
Sbjct: 342  SLSLQ 346



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 69/272 (25%), Positives = 98/272 (36%), Gaps = 49/272 (18%)

Query: 843  QVPSHGRFQ--AKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV 900
            Q  +HGRF      + N+  L +R+   GDSG Y  +     GS   +  +      V  
Sbjct: 95   QEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVER--GSRKWNYIYDKLSVHVTA 152

Query: 901  -------SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLT 953
                   S    L+ G    L+C V     +GT       G  +        R + ++L 
Sbjct: 153  LTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLI 212

Query: 954  QAGAYH-----CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL------ 1002
                 H     CQ   PG+  T   A + L++SY P+++T+T     G     L      
Sbjct: 213  PQPQDHGTSLTCQVTLPGAGVTMTRA-VRLNISYPPQNLTMTVFQGDGTASTTLRNGSAL 271

Query: 1003 ---------LLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLE 1053
                     L+C VDS+PPA+L    G  L  S  Q         PR+HV          
Sbjct: 272  SVLEGQSLHLVCAVDSNPPARLSWTWGS-LTLSPSQSSNLGVLELPRVHV---------- 320

Query: 1054 IHGAMLEDEGVYICEASNTLGQASASADFDAQ 1085
                  +DEG + C A N LG    S     Q
Sbjct: 321  ------KDEGEFTCRAQNPLGSQHISLSLSLQ 346



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 48/200 (24%), Positives = 79/200 (39%), Gaps = 34/200 (17%)

Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPL---ETVTLLPVARTDAALYA 773
           TL+ G   NLTC+V      G+P   +W    V      +     ++L+P  +       
Sbjct: 164 TLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLT 223

Query: 774 CRI-LTEAGAQLSTPVLLSVLYPPDRPKLSAL---------------LDMGQGHMALFIC 817
           C++ L  AG  ++  V L++ YPP    ++                 L + +G     +C
Sbjct: 224 CQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVC 283

Query: 818 TVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCE 877
            VDS P A L+   G   L+ S                +N   LE+  + + D G + C 
Sbjct: 284 AVDSNPPARLSWTWGSLTLSPS--------------QSSNLGVLELPRVHVKDEGEFTCR 329

Query: 878 ATNVLGSSNTSLFFQVRGAW 897
           A N LGS + SL   ++  +
Sbjct: 330 AQNPLGSQHISLSLSLQNEY 349



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 40/133 (30%), Positives = 51/133 (38%), Gaps = 34/133 (25%)

Query: 1511 CLAELP-TGAAASAPVMLRVLYPPKTPTMMVFVEP--------EGGLRGILD-------C 1554
            C   LP  G   +  V L + YPP+  TM VF            G    +L+       C
Sbjct: 224  CQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVC 283

Query: 1555 RVDSEPLASLTLHLGSRLVASSQPQ--GAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612
             VDS P A L+   GS  ++ SQ    G    P +HV                 D+GE+ 
Sbjct: 284  AVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHV----------------KDEGEFT 327

Query: 1613 CSASNVLGSASTS 1625
            C A N LGS   S
Sbjct: 328  CRAQNPLGSQHIS 340



 Score = 41.2 bits (95), Expect = 0.009
 Identities = 54/239 (22%), Positives = 90/239 (37%), Gaps = 40/239 (16%)

Query: 1222 NTLRLELRGPQPRDEGFYSCSARSPLGQANTSLE-LRLEGVRVILAPEAAVP----EGAP 1276
            N   L +R  +  D G Y         + N   + L +    +   P  ++P     G P
Sbjct: 111  NNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHP 170

Query: 1277 ITVTCADPAA---HAPTLYTWYHNGRWLQEGP---AASLSFLVATRAHAGAYSCQAQ-DA 1329
              +TC+ P A     P   TW        +     ++ LS +   + H  + +CQ     
Sbjct: 171  RNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPG 230

Query: 1330 QGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV---------------IQCTVDSEPP 1374
             G   +R   L + Y PQ+  ++ F+     S  +               + C VDS PP
Sbjct: 231  AGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPP 290

Query: 1375 AELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGS 1433
            A L+ +     L+ S      +S  G +++     R+ V+D    +  + C AQN LGS
Sbjct: 291  ARLSWTWGSLTLSPSQ-----SSNLGVLELP----RVHVKD----EGEFTCRAQNPLGS 336



 Score = 37.4 bits (85), Expect = 0.13
 Identities = 63/266 (23%), Positives = 98/266 (36%), Gaps = 50/266 (18%)

Query: 467 GTSGPNSLRLEIRDLEETDSGEYKCSA---TNSLGNATSTLDFHANAARLL--ISPAAEV 521
           G    N+  L IRD  + DSG+Y       +         L  H  A   +   S    +
Sbjct: 106 GDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTL 165

Query: 522 VEGQ------AVTLSCRSGLSPTPDARFSWYLNGALLHEGPG---SSLLLPAASSTDAG- 571
             G       +V  +C  G  PT     +W +  ++    P    SS+L       D G 
Sbjct: 166 ESGHPRNLTCSVPWACEQGTPPT----ITW-MGASVSSLDPTITRSSMLSLIPQPQDHGT 220

Query: 572 SYHCRARDGHSASGPSSPAVLTVLYPPRQPTFT----------TRLDLDAAGAGAGRRGL 621
           S  C+     +    +    L + YPP+  T T          T  +  A     G+   
Sbjct: 221 SLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLH 280

Query: 622 LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLL 681
           L+C VDS+PPARL                    T G  S  +  +++ NL  +E+    +
Sbjct: 281 LVCAVDSNPPARLSW------------------TWG--SLTLSPSQSSNLGVLELPRVHV 320

Query: 682 EEEGLYLCEASNALGNASTSATFNGQ 707
           ++EG + C A N LG+   S + + Q
Sbjct: 321 KDEGEFTCRAQNPLGSQHISLSLSLQ 346


>gi|16506828 sialic acid binding immunoglobulin-like lectin-like
           protein 1 isoform a precursor [Homo sapiens]
          Length = 595

 Score = 95.5 bits (236), Expect = 4e-19
 Identities = 82/310 (26%), Positives = 135/310 (43%), Gaps = 33/310 (10%)

Query: 26  PQDVQGVKGSCLLIPCIFSFPA-DVEVPDGITAIWYY---DYSGQRQVVSHSADPKLVEA 81
           P+ V   +G C+ +PC   +P  +      +   W+    D      V +++   K+ E 
Sbjct: 156 PESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQED 215

Query: 82  RFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTL-VTVTEEPR 140
              GR   +G+P+   C+L ++D +  DSG Y F+ E     +W+ +   L V VT    
Sbjct: 216 T-HGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGS-RKWNYIYDKLSVHVTALTH 273

Query: 141 VPTIASPVELLEGTEVDFNCSTPYVCLQ-EQVRLQWQGQDPARSVTFNSQKFEPTGVGHL 199
           +PT + P  L  G   +  CS P+ C Q     + W G         +    +PT +   
Sbjct: 274 MPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGA--------SVSSLDPT-ITRS 324

Query: 200 ETLHMAMSWQDHGRILRCQLSV--ANHRAQSEIHLQVKYAPKGVKI------------LL 245
             L +    QDHG  L CQ+++  A       + L + Y P+ + +            L 
Sbjct: 325 SMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLR 384

Query: 246 SPSGRNILPGELVTLTCQVNSSYPAVSSIKW--LKDGVRLQTKTGVLHLPQAAWSDAGVY 303
           + S  ++L G+ + L C V+S+ PA  S  W  L       +  GVL LP+    D G +
Sbjct: 385 NGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEF 444

Query: 304 TCQAENGVGS 313
           TC+A+N +GS
Sbjct: 445 TCRAQNPLGS 454



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 71/245 (28%), Positives = 99/245 (40%), Gaps = 42/245 (17%)

Query: 1048 NTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVW--------PGATVRE 1099
            N   L I  A   D G Y  +     G    +  +D  +V+V           PG T+  
Sbjct: 229  NNCSLSIRDARKGDSGKYYFQVER--GSRKWNYIYDKLSVHVTALTHMPTFSIPG-TLES 285

Query: 1100 GQLVNLTCLV-WTTHPAQL-TYTWYQDGQQRLDA--------HSIPLPNVTVRDATSYRC 1149
            G   NLTC V W        T TW       LD           IP P       TS  C
Sbjct: 286  GHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQ---DHGTSLTC 342

Query: 1150 GVGPPGRAPRLSRPITLDVLYAPRNLRLTYL---------------LESHGGQLALVLCT 1194
             V  PG    ++R + L++ Y P+NL +T                 L    GQ   ++C 
Sbjct: 343  QVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCA 402

Query: 1195 VDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSL 1254
            VDS PPA+L+ +     L+ S ++   N   LEL     +DEG ++C A++PLG  + SL
Sbjct: 403  VDSNPPARLSWTWGSLTLSPSQSS---NLGVLELPRVHVKDEGEFTCRAQNPLGSQHISL 459

Query: 1255 ELRLE 1259
             L L+
Sbjct: 460  SLSLQ 464



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 69/272 (25%), Positives = 98/272 (36%), Gaps = 49/272 (18%)

Query: 843  QVPSHGRFQ--AKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV 900
            Q  +HGRF      + N+  L +R+   GDSG Y  +     GS   +  +      V  
Sbjct: 213  QEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVER--GSRKWNYIYDKLSVHVTA 270

Query: 901  -------SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLT 953
                   S    L+ G    L+C V     +GT       G  +        R + ++L 
Sbjct: 271  LTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLI 330

Query: 954  QAGAYH-----CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL------ 1002
                 H     CQ   PG+  T   A + L++SY P+++T+T     G     L      
Sbjct: 331  PQPQDHGTSLTCQVTLPGAGVTMTRA-VRLNISYPPQNLTMTVFQGDGTASTTLRNGSAL 389

Query: 1003 ---------LLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLE 1053
                     L+C VDS+PPA+L    G  L  S  Q         PR+HV          
Sbjct: 390  SVLEGQSLHLVCAVDSNPPARLSWTWGS-LTLSPSQSSNLGVLELPRVHV---------- 438

Query: 1054 IHGAMLEDEGVYICEASNTLGQASASADFDAQ 1085
                  +DEG + C A N LG    S     Q
Sbjct: 439  ------KDEGEFTCRAQNPLGSQHISLSLSLQ 464



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 95/447 (21%), Positives = 168/447 (37%), Gaps = 77/447 (17%)

Query: 18  QASWGVSSPQDVQGVKGSCLLIPCIFSFPADV-EVPDGITAIWYY--DYSGQRQVVSHSA 74
           Q  + ++  + V   +G C+ + C FS+P +     D +   W+   D+  +   V+ + 
Sbjct: 21  QKDYLLTMQKSVTVQEGLCVSVLCSFSYPQNGWTASDPVHGYWFRAGDHVSRNIPVATNN 80

Query: 75  DPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWS---DVKGT 131
             + V+   R R   +G+P+++ C L ++D +  D+G+Y F  E   + +W+   D    
Sbjct: 81  PARAVQEETRDRFHLLGDPQNKDCTLSIRDTRESDAGTYVFCVERGNM-KWNYKYDQLSV 139

Query: 132 LVTVTEEPRVP---TIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNS 188
            VT +++        +   V + EG  V   CS  Y          W    P     F  
Sbjct: 140 NVTASQDLLSRYRLEVPESVTVQEGLCVSVPCSVLY------PHYNWTASSPVYGSWFKE 193

Query: 189 QKFEPTGVGHLETLHMAMSWQD-HGRIL--------RCQLSVANHRA--QSEIHLQVKYA 237
               P  +            +D HGR L         C LS+ + R     + + QV+  
Sbjct: 194 GADIPWDIPVATNTPSGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERG 253

Query: 238 PKGVKILLSPSGRNI----------LPGELVT-----LTCQV--NSSYPAVSSIKWLKDG 280
            +    +      ++          +PG L +     LTC V          +I W+   
Sbjct: 254 SRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGAS 313

Query: 281 VR----LQTKTGVLHLPQAAWSDAGVYTCQAE-NGVG---------SLVSPP--ISLHIF 324
           V       T++ +L L           TCQ    G G         ++  PP  +++ +F
Sbjct: 314 VSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVF 373

Query: 325 MAEVQVS------PAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTL--- 375
             +   S       A  +LE Q++ LVC   +  P+ L ++W    + L  + S  L   
Sbjct: 374 QGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTW--GSLTLSPSQSSNLGVL 431

Query: 376 ---RLHLATRADTGFYFCEVQNVHGSE 399
              R+H+    D G + C  QN  GS+
Sbjct: 432 ELPRVHV---KDEGEFTCRAQNPLGSQ 455



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 48/200 (24%), Positives = 79/200 (39%), Gaps = 34/200 (17%)

Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPL---ETVTLLPVARTDAALYA 773
           TL+ G   NLTC+V      G+P   +W    V      +     ++L+P  +       
Sbjct: 282 TLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLT 341

Query: 774 CRI-LTEAGAQLSTPVLLSVLYPPDRPKLSAL---------------LDMGQGHMALFIC 817
           C++ L  AG  ++  V L++ YPP    ++                 L + +G     +C
Sbjct: 342 CQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVC 401

Query: 818 TVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCE 877
            VDS P A L+   G   L+ S                +N   LE+  + + D G + C 
Sbjct: 402 AVDSNPPARLSWTWGSLTLSPS--------------QSSNLGVLELPRVHVKDEGEFTCR 447

Query: 878 ATNVLGSSNTSLFFQVRGAW 897
           A N LGS + SL   ++  +
Sbjct: 448 AQNPLGSQHISLSLSLQNEY 467



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 40/133 (30%), Positives = 51/133 (38%), Gaps = 34/133 (25%)

Query: 1511 CLAELP-TGAAASAPVMLRVLYPPKTPTMMVFVEP--------EGGLRGILD-------C 1554
            C   LP  G   +  V L + YPP+  TM VF            G    +L+       C
Sbjct: 342  CQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVC 401

Query: 1555 RVDSEPLASLTLHLGSRLVASSQPQ--GAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612
             VDS P A L+   GS  ++ SQ    G    P +HV                 D+GE+ 
Sbjct: 402  AVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHV----------------KDEGEFT 445

Query: 1613 CSASNVLGSASTS 1625
            C A N LGS   S
Sbjct: 446  CRAQNPLGSQHIS 458



 Score = 41.2 bits (95), Expect = 0.009
 Identities = 54/239 (22%), Positives = 90/239 (37%), Gaps = 40/239 (16%)

Query: 1222 NTLRLELRGPQPRDEGFYSCSARSPLGQANTSLE-LRLEGVRVILAPEAAVP----EGAP 1276
            N   L +R  +  D G Y         + N   + L +    +   P  ++P     G P
Sbjct: 229  NNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHP 288

Query: 1277 ITVTCADPAA---HAPTLYTWYHNGRWLQEGP---AASLSFLVATRAHAGAYSCQAQ-DA 1329
              +TC+ P A     P   TW        +     ++ LS +   + H  + +CQ     
Sbjct: 289  RNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPG 348

Query: 1330 QGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV---------------IQCTVDSEPP 1374
             G   +R   L + Y PQ+  ++ F+     S  +               + C VDS PP
Sbjct: 349  AGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPP 408

Query: 1375 AELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGS 1433
            A L+ +     L+ S      +S  G +++     R+ V+D    +  + C AQN LGS
Sbjct: 409  ARLSWTWGSLTLSPSQ-----SSNLGVLELP----RVHVKD----EGEFTCRAQNPLGS 454



 Score = 37.4 bits (85), Expect = 0.13
 Identities = 63/266 (23%), Positives = 98/266 (36%), Gaps = 50/266 (18%)

Query: 467 GTSGPNSLRLEIRDLEETDSGEYKCSA---TNSLGNATSTLDFHANAARLL--ISPAAEV 521
           G    N+  L IRD  + DSG+Y       +         L  H  A   +   S    +
Sbjct: 224 GDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTL 283

Query: 522 VEGQ------AVTLSCRSGLSPTPDARFSWYLNGALLHEGPG---SSLLLPAASSTDAG- 571
             G       +V  +C  G  PT     +W +  ++    P    SS+L       D G 
Sbjct: 284 ESGHPRNLTCSVPWACEQGTPPT----ITW-MGASVSSLDPTITRSSMLSLIPQPQDHGT 338

Query: 572 SYHCRARDGHSASGPSSPAVLTVLYPPRQPTFT----------TRLDLDAAGAGAGRRGL 621
           S  C+     +    +    L + YPP+  T T          T  +  A     G+   
Sbjct: 339 SLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLH 398

Query: 622 LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLL 681
           L+C VDS+PPARL                    T G  S  +  +++ NL  +E+    +
Sbjct: 399 LVCAVDSNPPARLSW------------------TWG--SLTLSPSQSSNLGVLELPRVHV 438

Query: 682 EEEGLYLCEASNALGNASTSATFNGQ 707
           ++EG + C A N LG+   S + + Q
Sbjct: 439 KDEGEFTCRAQNPLGSQHISLSLSLQ 464


>gi|157694526 Fc receptor-like 5 [Homo sapiens]
          Length = 977

 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 199/821 (24%), Positives = 288/821 (35%), Gaps = 126/821 (15%)

Query: 200 ETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVT 259
           ET    +  Q+ G   RCQ         S +HL    A      L+  +  ++  G+ V 
Sbjct: 69  ETPDNILEVQESGEY-RCQAQ--GSPLSSPVHLDFSSAS-----LILQAPLSVFEGDSVV 120

Query: 260 LTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPI 319
           L C+  +     ++I    + +    K    H+P A   D G Y C            P+
Sbjct: 121 LRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKE----SCCPV 176

Query: 320 SLHIFMAEVQVSPAGPIL--------ENQTVTLVCNTP---NEAPSDLRYSWYKNHVLLE 368
           S +    +VQ     P+L            VTL C T      +   LR+ ++++   L 
Sbjct: 177 SSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLG 236

Query: 369 DAHSHTLRLHLAT--RADTGFYFCEVQNVHGSERS-GPVS-VVVNHPPLTPVLTAFLETQ 424
              S +    +      D+GFY+C+   +  S  S  P S + V  P   PVLT   E  
Sbjct: 237 LGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKA 296

Query: 425 AGLVG---ILHCSVVSEPLATLV-LSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRD 480
               G    LHC    + L TL    H G  L   S   +      G S   SL  E   
Sbjct: 297 LNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCER-----GASISFSLTTE--- 348

Query: 481 LEETDSGEYKCSATNSLGNATS---TLDFHANAARLLI---SPAAEVVEGQAVTLSCRSG 534
               +SG Y C+A N LG   S   +L      +  ++   SP   + EG  VTL C + 
Sbjct: 349 ----NSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQ 404

Query: 535 LSPTPDARFSWYLNGALLH----EGPGSSLLLPAASSTDAGSYHCRARDGHSASGP--SS 588
               P   + ++  GA L        G   +  + ++  +G+Y+C A +G    GP  S 
Sbjct: 405 RGSLP-ILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGF---GPQRSK 460

Query: 589 PAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARL-QLLHKDRVVATSL 647
              L+V  P   P  T  L    A    G    L C V    P  L Q  H+D  + +S 
Sbjct: 461 AVSLSVTVPVSHPVLT--LSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSS- 517

Query: 648 PSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLE-EEGLYLCEASNALGNASTSATFNG 706
                                P++ RV     L E   G Y C A N  G    S   + 
Sbjct: 518 -------------------STPSVGRVSFSFSLTEGHSGNYYCTADNGFG-PQRSEVVSL 557

Query: 707 QATVLAIAPSHTLQ-------EGTEANLTCNVSREAAGSPANFSWFRN-----GVLWAQG 754
             TV    P  TL+        G    L C   R   GSP    WF +     G   A  
Sbjct: 558 FVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPR---GSPPILYWFYHEDVTLGSSSAPS 614

Query: 755 PLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQ---GH 811
             E    L +    +  Y+C       AQ S  + LSV+ P  RP L+      Q   G 
Sbjct: 615 GGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGD 674

Query: 812 MALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDS 871
           +    C        +L  F+ E +    +    PS G       + +L L         S
Sbjct: 675 LLELHCEALRGSSPILYWFYHEDVTLGKI--SAPSGG-----GASFNLSLTTEH-----S 722

Query: 872 GSYRCEATNVLGSSNTSLFF------QVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEG 925
           G Y CEA N L +  + +          R      +P      G  + L C+   G P  
Sbjct: 723 GIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPL- 781

Query: 926 TSYRWYRD----GQPLQESTSATLRFAAITLTQAGAYHCQA 962
             YR++ +    G     S  A+L   ++T   +G Y C+A
Sbjct: 782 ILYRFFHEDVTLGNRSSPSGGASLNL-SLTAEHSGNYSCEA 821



 Score = 92.0 bits (227), Expect = 4e-18
 Identities = 162/685 (23%), Positives = 251/685 (36%), Gaps = 95/685 (13%)

Query: 99  NLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIA-SPVELL--EGTE 155
           N  +  +  +DSG Y  +      +  SD   + + V      P +  SP + L  EGT+
Sbjct: 244 NFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTK 303

Query: 156 VDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRIL 215
           V  +C T    L+   R   +G  P R  +   ++          ++  +++ ++ G   
Sbjct: 304 VTLHCETQEDSLRTLYRFYHEGV-PLRHKSVRCERGA--------SISFSLTTENSGNYY 354

Query: 216 RCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVN-SSYPAVSSI 274
               +    +    + L V        + LS     I  G  VTL C+    S P +   
Sbjct: 355 CTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPIL--Y 412

Query: 275 KWLKDGVRLQTKT-----GVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQ 329
           ++  +G  L+ ++     GV          +G Y C A+NG G   S  +SL      V 
Sbjct: 413 QFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSL-----SVT 467

Query: 330 VSPAGPIL----------ENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHL 379
           V  + P+L          E  TVTL C     +P  L   ++++  L   +     R+  
Sbjct: 468 VPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSF 527

Query: 380 A---TRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVG---ILHC 433
           +   T   +G Y+C   N  G +RS  VS+ V  P   P+LT  +     +VG    LHC
Sbjct: 528 SFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHC 587

Query: 434 SVV-SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCS 492
                 P       H    L S+S  S     F+              L    SG Y C 
Sbjct: 588 EAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFN------------LSLTAEHSGNYSCE 635

Query: 493 ATNSL---GNATSTLDFHANAARLLI---SPAAEVVEGQAVTLSCRSGLSPTPDARFSWY 546
           A N L    + T +L      +R ++   +P A+ V G  + L C +    +P   + ++
Sbjct: 636 ANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYH 695

Query: 547 ----LNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPT 602
               L       G G+S  L + ++  +G Y C A +G  A   S    L V  P  +P 
Sbjct: 696 EDVTLGKISAPSGGGASFNL-SLTTEHSGIYSCEADNGLEAQ-RSEMVTLKVAVPVSRPV 753

Query: 603 FTTRLDLDAAGAGAGRRGLLLCRVDS---DPPARLQLLHKDRVVATSLPSGGGCSTCGGC 659
            T R    A G  A    LL    ++    P    +  H+D      +  G   S  GG 
Sbjct: 754 LTLR----APGTHAAVGDLLELHCEALRGSPLILYRFFHED------VTLGNRSSPSGGA 803

Query: 660 SPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTL 719
           S  + +T               E  G Y CEA N LG A  S T     T L    S   
Sbjct: 804 SLNLSLT--------------AEHSGNYSCEADNGLG-AQRSETVTLYITGLTANRSGPF 848

Query: 720 QEGTEANLTCNVSREAAGSPANFSW 744
             G    L  +++  AAG+   + W
Sbjct: 849 ATGVAGGL-LSIAGLAAGALLLYCW 872



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 216/888 (24%), Positives = 310/888 (34%), Gaps = 142/888 (15%)

Query: 243  ILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW----LKDGVRLQTKTGVLHLPQAAWS 298
            I L P    +  GE VTLTC+    Y +    KW    L   +  +T   +L +      
Sbjct: 25   IFLQPPWTTVFQGERVTLTCKGFRFY-SPQKTKWYHRYLGKEILRETPDNILEV-----Q 78

Query: 299  DAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRY 358
            ++G Y CQA+   GS +S P+ L    A + +     + E  +V L C    +A   L  
Sbjct: 79   ESGEYRCQAQ---GSPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRA--KAEVTLNN 133

Query: 359  SWYKNHVLLEDAHSHT-LRLHLATRADTGFYFCE-VQNVHGSERSGPVSVVVNHPPLTPV 416
            + YKN  +L   +  T   +  A   D G Y C   +       S  V + V  P   PV
Sbjct: 134  TIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPV 193

Query: 417  LTA-FLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLR 475
            L A   +  +G    L C         L L      L       D +     +  PN   
Sbjct: 194  LRASSFQPISGNPVTLTCE------TQLSLERSDVPLRFRFFRDDQTLGLGWSLSPN--- 244

Query: 476  LEIRDLEETDSGEYKCSATNSLGNATS-------TLDFHANAARLLISPAAEV-VEGQAV 527
             +I  +   DSG Y C A     +  S        +   A+   L +SP   +  EG  V
Sbjct: 245  FQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKV 304

Query: 528  TLSCRSGLSPTPDARFSWYLNGA-LLHEG----PGSSLLLPAASSTDAGSYHCRARDGHS 582
            TL C +    +    + +Y  G  L H+      G+S+   + ++ ++G+Y+C A +G  
Sbjct: 305  TLHCET-QEDSLRTLYRFYHEGVPLRHKSVRCERGASISF-SLTTENSGNYYCTADNGLG 362

Query: 583  ASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVD-SDPPARLQLLHKDR 641
            A  PS    L+V  P   P        D    GA  +  L C       P   Q  H+  
Sbjct: 363  AK-PSKAVSLSVTVPVSHPVLNLSSPEDLIFEGA--KVTLHCEAQRGSLPILYQFHHEGA 419

Query: 642  VVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG----- 696
             +          ++ GG +    +T               E  G Y C A N  G     
Sbjct: 420  ALERR-----SANSAGGVAISFSLT--------------AEHSGNYYCTADNGFGPQRSK 460

Query: 697  NASTSATFNGQATVLAIAPSHTLQ-EGTEANLTCNVSREAAGSPANFSWF--RNGVLWAQ 753
              S S T      VL ++ +  L  EG    L C V R   GSP     F   +  LW+ 
Sbjct: 461  AVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQR---GSPQILYQFYHEDMPLWSS 517

Query: 754  GPLETVTL---LPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQ- 809
                   +     +    +  Y C      G Q S  V L V  P  RP L+  +   Q 
Sbjct: 518  STPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQA 577

Query: 810  --GHMALFICTVD-SRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEAN-SLKLEVRE 865
              G +    C      P  L   +H +  L +S     PS G    +A  N SL  E   
Sbjct: 578  VVGDLLELHCEAPRGSPPILYWFYHEDVTLGSS---SAPSGG----EASFNLSLTAE--- 627

Query: 866  LGLGDSGSYRCEATNVL---GSSNTSLFFQV---RGAWVQVSPSPELQEGQAVVLSCQVH 919
                 SG+Y CEA N L    S   SL   V   R      +P  +   G  + L C+  
Sbjct: 628  ----HSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEAL 683

Query: 920  TGVPEGTSYRWYRD---GQPLQESTSATLRFAAITLTQAGAYHC------QAQAPGSATT 970
             G      + ++ D   G+    S        ++T   +G Y C      +AQ     T 
Sbjct: 684  RGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTL 743

Query: 971  SLAAPIS---LHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQL-RLLHGDRLVAS 1026
             +A P+S   L +     H  +  L++        L C      P  L R  H D     
Sbjct: 744  KVAVPVSRPVLTLRAPGTHAAVGDLLE--------LHCEALRGSPLILYRFFHED----V 791

Query: 1027 TLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLG 1074
            TL     P G +          +L L +     E  G Y CEA N LG
Sbjct: 792  TLGNRSSPSGGA----------SLNLSL---TAEHSGNYSCEADNGLG 826



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 178/698 (25%), Positives = 246/698 (35%), Gaps = 114/698 (16%)

Query: 244 LLSPSGRNILPGELVTLTCQVNSSYPAVS---SIKWLKDGVRLQTKTGVLHLPQ--AAWS 298
           +L  S    + G  VTLTC+   S          ++ +D   L     +    Q  A WS
Sbjct: 193 VLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWS 252

Query: 299 -DAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPIL----------ENQTVTLVCN 347
            D+G Y C+A     S++S      I   +VQ+  + P+L          E   VTL C 
Sbjct: 253 KDSGFYWCKAATMPYSVISDSPRSWI---QVQIPASHPVLTLSPEKALNFEGTKVTLHCE 309

Query: 348 TPNEAPSDLRYSWYKNHVLLEDAHSHTLR----LHLATRADTGFYFCEVQNVHGSERSGP 403
           T  ++   L Y +Y   V L        R        T  ++G Y+C   N  G++ S  
Sbjct: 310 TQEDSLRTL-YRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKA 368

Query: 404 VSVVVNHPPLTPVLTAFLETQAGLVGI---LHCSVVSEPLATLV-LSHGGHILASTSGDS 459
           VS+ V  P   PVL           G    LHC      L  L    H G  L   S +S
Sbjct: 369 VSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANS 428

Query: 460 DHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATS-----TLDFHANAARLL 514
                  G +   SL  E        SG Y C+A N  G   S     ++    +   L 
Sbjct: 429 A-----GGVAISFSLTAE-------HSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLT 476

Query: 515 ISPA-AEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEG--PGSSLLLPAASSTD-- 569
           +S A A   EG  VTL C      +P   + +Y     L     P    +  + S T+  
Sbjct: 477 LSSAEALTFEGATVTLHCEVQRG-SPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGH 535

Query: 570 AGSYHCRARDGHSASGPSSPAVLT--VLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVD 627
           +G+Y+C A +G    GP    V++  V  P  +P  T R+    A A  G    L C   
Sbjct: 536 SGNYYCTADNGF---GPQRSEVVSLFVTVPVSRPILTLRVP--RAQAVVGDLLELHCEAP 590

Query: 628 -SDPPARLQLLHKDRVV-ATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685
              PP      H+D  + ++S PSGG  S        + +T               E  G
Sbjct: 591 RGSPPILYWFYHEDVTLGSSSAPSGGEASF------NLSLTA--------------EHSG 630

Query: 686 LYLCEASNALGNASTSATFNGQATVLAIAPSHTLQE-------GTEANLTCNVSREAAGS 738
            Y CEA+N L  A  S T +    V    P  T +        G    L C   R   GS
Sbjct: 631 NYSCEANNGLV-AQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALR---GS 686

Query: 739 PANFSWFRN-----GVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVL 793
                WF +     G + A         L +    + +Y+C       AQ S  V L V 
Sbjct: 687 SPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVA 746

Query: 794 YPPDRPKLSALLD---MGQGHMALFIC-TVDSRPLALLALFHGEHLLATSLGPQVPSHGR 849
            P  RP L+          G +    C  +   PL L   FH +  L     P   +   
Sbjct: 747 VPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPSGGASLN 806

Query: 850 FQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNT 887
               AE               SG+Y CEA N LG+  +
Sbjct: 807 LSLTAE--------------HSGNYSCEADNGLGAQRS 830



 Score = 74.7 bits (182), Expect = 7e-13
 Identities = 206/884 (23%), Positives = 314/884 (35%), Gaps = 162/884 (18%)

Query: 866  LGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEG 925
            L + +SG YRC+A     SS   L F      +Q   S  + EG +VVL C+    V   
Sbjct: 75   LEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLS--VFEGDSVVLRCRAKAEVTLN 132

Query: 926  TSYRWYRDGQPLQESTSAT-LRFAAITLTQAGAYHC----QAQAPGSATT-------SLA 973
             +   Y++   L      T        L   GAY C    ++  P S+ T          
Sbjct: 133  NTI--YKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFT 190

Query: 974  APISLHVSYAP---RHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQG 1030
             P+    S+ P     VTLT        R         SD P + R    D+ +     G
Sbjct: 191  RPVLRASSFQPISGNPVTLTCETQLSLER---------SDVPLRFRFFRDDQTL-----G 236

Query: 1031 VGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQ 1090
            +G           +++PN    +I     +D G Y C+A+      S  +D     + VQ
Sbjct: 237  LGW----------SLSPN---FQITAMWSKDSGFYWCKAATM--PYSVISDSPRSWIQVQ 281

Query: 1091 V---WPGATVREGQLVNLTCLVWTTH------PAQLTYTWYQDG------QQRLDAHSIP 1135
            +    P  T+   + +N      T H        +  Y +Y +G        R +  +  
Sbjct: 282  IPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASI 341

Query: 1136 LPNVTVRDATSYRC----GVGP-PGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLAL 1190
              ++T  ++ +Y C    G+G  P +A  LS  +T+ V +   NL     L   G ++ L
Sbjct: 342  SFSLTTENSGNYYCTADNGLGAKPSKAVSLS--VTVPVSHPVLNLSSPEDLIFEGAKVTL 399

Query: 1191 VLCTVDSRPPAQLALSHAGRLLASSTAASVPNT-LRLELRGPQPRDEGFYSCSARSPLG- 1248
                     P      H G  L   +A S     +   L        G Y C+A +  G 
Sbjct: 400  HCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEH---SGNYYCTADNGFGP 456

Query: 1249 QANTSLELRL-----EGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGR--WL 1301
            Q + ++ L +       V  + + EA   EGA +T+ C         LY +YH     W 
Sbjct: 457  QRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWS 516

Query: 1302 QEGPAA---SLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSR 1358
               P+    S SF + T  H+G Y C A +  G + S   +L V   P    + + R  R
Sbjct: 517  SSTPSVGRVSFSFSL-TEGHSGNYYCTADNGFGPQRSEVVSLFVT-VPVSRPILTLRVPR 574

Query: 1359 ARSMA----VIQCTVD-SEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQV 1413
            A+++      + C      PP      H+   L +SS      SG         +  L +
Sbjct: 575  AQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSA----PSG------GEASFNLSL 624

Query: 1414 QDVPAGDDTYVCTAQN-LLGSISTIGRLQV-----EGARVVAEPGLDVPEGAALNLSCRL 1467
                +G+  Y C A N L+   S    L V             P      G  L L C  
Sbjct: 625  TAEHSGN--YSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEA 682

Query: 1468 LGGPGPVGNSTFAWFWNDR----RLHAEPVPTLAFT-HVARAQAGMYHCLAELPTGAAAS 1522
            L G  P+      WF+++     ++ A      +F   +    +G+Y C A+    A  S
Sbjct: 683  LRGSSPI----LYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRS 738

Query: 1523 APVMLRVLYPPKTPTMMVFVEPEGGLRG-ILDCRVDSEPLASLTLH--------LGSRLV 1573
              V L+V  P   P + +         G +L+   ++   + L L+        LG+R  
Sbjct: 739  EMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNR-- 796

Query: 1574 ASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTST---YFGV 1630
              S P G          AS N       +L     G Y C A N LG+  + T   Y   
Sbjct: 797  --SSPSGG---------ASLNL------SLTAEHSGNYSCEADNGLGAQRSETVTLYITG 839

Query: 1631 RALHRLHQFQQ-----LLWVLGLLVGLLLLLLGLGACYTWRRRR 1669
               +R   F       LL + GL  G LLL       Y W  R+
Sbjct: 840  LTANRSGPFATGVAGGLLSIAGLAAGALLL-------YCWLSRK 876



 Score = 32.7 bits (73), Expect = 3.1
 Identities = 29/121 (23%), Positives = 48/121 (39%), Gaps = 7/121 (5%)

Query: 1267 PEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQA 1326
            P   V +G  +T+TC     ++P    WYH  R+L +         +     +G Y CQ 
Sbjct: 30   PWTTVFQGERVTLTCKGFRFYSPQKTKWYH--RYLGKEILRETPDNILEVQESGEYRCQ- 86

Query: 1327 QDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVL 1386
              AQG+  S P  L   ++    +L +          V++C   +E      +  +  VL
Sbjct: 87   --AQGSPLSSPVHLD--FSSASLILQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVL 142

Query: 1387 A 1387
            A
Sbjct: 143  A 143


>gi|15147240 brother of CDO [Homo sapiens]
          Length = 1114

 Score = 92.0 bits (227), Expect = 4e-18
 Identities = 109/395 (27%), Positives = 166/395 (42%), Gaps = 60/395 (15%)

Query: 898  VQVSPSPELQE-GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQES--------TSATLRFA 948
            V V P+  +Q+ G  V+L C V    P   +  W  +G+ L  S        T  TL   
Sbjct: 38   VTVQPASTVQKPGGTVILGCVVE---PPRMNVTWRLNGKELNGSDDALGVLITHGTLVIT 94

Query: 949  AITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRV- 1007
            A+     G Y C A+ P  A  S+ A ++L  +     + +  +++   G   ++ C + 
Sbjct: 95   ALNNHTVGRYQCVARMPAGAVASVPATVTL-ANLQDFKLDVQHVIEVDEGNTAVIACHLP 153

Query: 1008 DSDPPAQLRL-LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYI 1066
            +S P AQ+R  +  + L AS    +  P G+              L+I  A  EDEG+Y 
Sbjct: 154  ESHPKAQVRYSVKQEWLEASRGNYLIMPSGN--------------LQIVNASQEDEGMYK 199

Query: 1067 CEASNTLGQ---ASASAD------FDAQAVNVQVWPGAT---VREGQLVNLTCLVWTTHP 1114
            C A N + Q    S S+D        A+A  +   P A    V +GQ + L C+     P
Sbjct: 200  CAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPP 259

Query: 1115 AQLTYTWYQDGQQ-------RLDAHSIPLPNVTVRDATSYRC----GVGPPGRAPRLSRP 1163
             ++T  W +DG         R    ++ +   +  D+ +YRC    GVG PG A  L   
Sbjct: 260  PRVT--WAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVIL--- 314

Query: 1164 ITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQ-LALSHAGRLLASSTAASVPN 1222
              + V   P        L    GQ A + C V   PP   L L +A  L++S        
Sbjct: 315  YNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRR 374

Query: 1223 TLRLELRGPQPRDEGFYSCSARSPLGQANTSLELR 1257
             LR+   GP+  DEG Y C A + +G A+  ++LR
Sbjct: 375  ALRVLSMGPE--DEGVYQCMAENEVGSAHAVVQLR 407



 Score = 68.6 bits (166), Expect = 5e-11
 Identities = 121/507 (23%), Positives = 201/507 (39%), Gaps = 69/507 (13%)

Query: 1073 LGQASASADFDAQAVNVQVWPGATVRE-GQLVNLTCLVWTTHPAQLTYTWYQDGQQRL-- 1129
            L  A   AD + +   V V P +TV++ G  V L C+V    P ++  TW  +G++    
Sbjct: 23   LATAGCFADLN-EVPQVTVQPASTVQKPGGTVILGCVV---EPPRMNVTWRLNGKELNGS 78

Query: 1130 -DAHSIPLPNVTV-------RDATSYRCGVG-PPGRAPRLSRPITLDVLYAPRNLRLTYL 1180
             DA  + + + T+            Y+C    P G    +   +TL  L   + L + ++
Sbjct: 79   DDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFK-LDVQHV 137

Query: 1181 LESHGGQLALVLCTV-DSRPPAQLALSHAGRLLASSTAAS-VPNTLRLELRGPQPRDEGF 1238
            +E   G  A++ C + +S P AQ+  S     L +S     +  +  L++      DEG 
Sbjct: 138  IEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGM 197

Query: 1239 YSCSARSPLGQ----ANTSLELRL-----EGVRVILAPEAA---VPEGAPITVTCADPAA 1286
            Y C+A +P+ Q    + +S  LR+     E  R+I  PEA    V +G  + + C     
Sbjct: 198  YKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGI 257

Query: 1287 HAPTLYTW---------YHNGRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRP 1337
              P + TW         Y+  R+L     ++L     +   +G Y C A +  G    +P
Sbjct: 258  PPPRV-TWAKDGSSVTGYNKTRFL----LSNLLIDTTSEEDSGTYRCMADNGVG----QP 308

Query: 1338 AALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLAS 1397
             A  +LY  Q  V      +   S  VI     ++   E+  +    VL   + V  ++S
Sbjct: 309  GAAVILYNVQ--VFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISS 366

Query: 1398 GTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPE 1457
                ++++R ALR+     P  +  Y C A+N +GS   + +L+     +      D   
Sbjct: 367  Q--RLRLSRRALRVLSMG-PEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQD--- 420

Query: 1458 GAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPT 1517
                     L  G  PV  S       ++ L  +P      T V  A      C  E   
Sbjct: 421  -------AELATGTPPVSPSKLG--NPEQMLRGQPALPRPPTSVGPASP---QCPGEKGQ 468

Query: 1518 GAAASAPVMLRVLYPPKTPTMMVFVEP 1544
            GA A AP++L      KT +  +   P
Sbjct: 469  GAPAEAPIILSSPRTSKTDSYELVWRP 495



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 98/400 (24%), Positives = 157/400 (39%), Gaps = 64/400 (16%)

Query: 327 EVQVSPAGPILE-NQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH--------TLRL 377
           +V V PA  + +   TV L C      P  +  +W  N   L  +           TL +
Sbjct: 37  QVTVQPASTVQKPGGTVILGCVVE---PPRMNVTWRLNGKELNGSDDALGVLITHGTLVI 93

Query: 378 HLATRADTGFYFCEVQNVHGSERSGPVSVVV-NHPPLTPVLTAFLETQAGLVGILHCSVV 436
                   G Y C  +   G+  S P +V + N       +   +E   G   ++ C + 
Sbjct: 94  TALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLP 153

Query: 437 -SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATN 495
            S P A +  S     L ++ G+    P         S  L+I +  + D G YKC+A N
Sbjct: 154 ESHPKAQVRYSVKQEWLEASRGNYLIMP---------SGNLQIVNASQEDEGMYKCAAYN 204

Query: 496 SLGNATSTLDFH---------ANAARLLISPAAE---VVEGQAVTLSCRSGLSPTPDARF 543
            +     T             A AAR++  P A+   V +GQ++ L C +   P P  R 
Sbjct: 205 PVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPP--RV 262

Query: 544 SWYLNGALLHEGPG-----SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
           +W  +G+ +          S+LL+   S  D+G+Y C A +G    G +       ++ P
Sbjct: 263 TWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEP 322

Query: 599 RQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGG 658
            + T    ++L       G+   L C V  +PP  +  L      A  L S         
Sbjct: 323 PEVT----MELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRN----AVPLIS--------- 365

Query: 659 CSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNA 698
            S R+++++    LRV    P  E+EG+Y C A N +G+A
Sbjct: 366 -SQRLRLSR--RALRVLSMGP--EDEGVYQCMAENEVGSA 400



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 94/366 (25%), Positives = 145/366 (39%), Gaps = 68/366 (18%)

Query: 1293 TWYHNGRWLQEGPAASLSFLV--------ATRAHA-GAYSCQAQDAQGTRSSRPAALQVL 1343
            TW  NG+ L  G   +L  L+        A   H  G Y C A+   G  +S PA + + 
Sbjct: 67   TWRLNGKELN-GSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTL- 124

Query: 1344 YAPQDAVLSSFR-------DSRARSMAVIQCTV-DSEPPAELALSHDGKVLATSSGVHSL 1395
                 A L  F+       +    + AVI C + +S P A++  S   + L  S G + L
Sbjct: 125  -----ANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNY-L 178

Query: 1396 ASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQN-LLGSISTIG---RLQV-----EGAR 1446
               +G++Q+        V      +  Y C A N +   + T G   RL+V     E AR
Sbjct: 179  IMPSGNLQI--------VNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAAR 230

Query: 1447 VVAEPGLD---VPEGAALNLSCRLLGGPGP-----VGNSTFAWFWNDRRLHAEPVPTLAF 1498
            ++  P      V +G +L L C   G P P        S+   +   R L    +  L  
Sbjct: 231  IIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFL----LSNLLI 286

Query: 1499 THVARAQAGMYHCLAELPTGAAASAPVM--LRVLYPPKTPTMMVFVEPEGGLRGILDCRV 1556
               +   +G Y C+A+   G   +A ++  ++V  PP+    +  +    G    L C V
Sbjct: 287  DTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEV 346

Query: 1557 DSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSAS 1616
               P  S+     +  + SSQ           +  S  ALRV   ++ P D+G Y C A 
Sbjct: 347  RGNPPPSVLWLRNAVPLISSQ----------RLRLSRRALRV--LSMGPEDEGVYQCMAE 394

Query: 1617 NVLGSA 1622
            N +GSA
Sbjct: 395  NEVGSA 400



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 76/324 (23%), Positives = 127/324 (39%), Gaps = 42/324 (12%)

Query: 49  VEVPDGITAI--WYYDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQ 106
           +EV +G TA+   +   S  +  V +S   + +EA  RG    M +   ++ N   +D  
Sbjct: 138 IEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEAS-RGNYLIMPSGNLQIVNASQEDEG 196

Query: 107 PEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRV--PTIASPVELLEGTEVDFNCSTPY 164
                +YN   +  + +  SD      +  E  R+  P  A  + + +G  +   C    
Sbjct: 197 MYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASG 256

Query: 165 VCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLS--VA 222
           +      R+ W  +D +    +N  +F       L  L +  + ++     RC     V 
Sbjct: 257 I---PPPRVTW-AKDGSSVTGYNKTRFL------LSNLLIDTTSEEDSGTYRCMADNGVG 306

Query: 223 NHRAQSEIHLQVKYAPKGVKILLSPSGRNILP-GELVTLTCQVNSSYPAVSSIKWLKDGV 281
              A   ++    + P  V + LS   + ++P G+   LTC+V  + P   S+ WL++ V
Sbjct: 307 QPGAAVILYNVQVFEPPEVTMELS---QLVIPWGQSAKLTCEVRGNPPP--SVLWLRNAV 361

Query: 282 ------RLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGP 335
                 RL+     L +      D GVY C AEN VGS            A VQ+  + P
Sbjct: 362 PLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSA----------HAVVQLRTSRP 411

Query: 336 ILEN---QTVTLVCNTPNEAPSDL 356
            +     Q   L   TP  +PS L
Sbjct: 412 SITPRLWQDAELATGTPPVSPSKL 435



 Score = 39.3 bits (90), Expect = 0.033
 Identities = 91/417 (21%), Positives = 148/417 (35%), Gaps = 63/417 (15%)

Query: 255 GELVTLTCQVNSSYPAVS---SIK--WLKD--GVRLQTKTGVLHLPQAAWSDAGVYTCQA 307
           G    + C +  S+P      S+K  WL+   G  L   +G L +  A+  D G+Y C A
Sbjct: 143 GNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAA 202

Query: 308 ENGVGSLVSPPISLHIFMAEVQVSPAGPIL-----------ENQTVTLVCNTPNEAPSDL 356
            N V   V    S          + A  I+           + Q++ L C      P   
Sbjct: 203 YNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPP-- 260

Query: 357 RYSWYKNHVLLEDAHS-----HTLRLHLATRADTGFYFCEVQNVHGSERSGPV--SVVVN 409
           R +W K+   +   +        L +   +  D+G Y C   N  G   +  +  +V V 
Sbjct: 261 RVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVF 320

Query: 410 HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTS 469
            PP   +  + L    G    L C V   P  +++       L S+        R S  +
Sbjct: 321 EPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQ-----RLRLSRRA 375

Query: 470 GPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA----AEVVEGQ 525
                 L +  +   D G Y+C A N +G+A + +      +R  I+P     AE+  G 
Sbjct: 376 ------LRVLSMGPEDEGVYQCMAENEVGSAHAVVQL--RTSRPSITPRLWQDAELATGT 427

Query: 526 AVTLSCRSGLSPTPDARFSWYLNGALLHEGPGS---------------SLLLPAASSTDA 570
                 + G +P    R    L       GP S                ++L +  ++  
Sbjct: 428 PPVSPSKLG-NPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKT 486

Query: 571 GSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVD 627
            SY    R  H  SG +   +L  +   R+ T ++  D   +G  A +  L L R+D
Sbjct: 487 DSYELVWRPRHEGSGRA--PILYYVVKHRKVTNSSD-DWTISGIPANQHRLTLTRLD 540



 Score = 38.1 bits (87), Expect = 0.074
 Identities = 92/429 (21%), Positives = 159/429 (37%), Gaps = 88/429 (20%)

Query: 512 RLLISPAAEVVE-GQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGS--------SLLL 562
           ++ + PA+ V + G  V L C   +   P    +W LNG  L+    +        +L++
Sbjct: 37  QVTVQPASTVQKPGGTVILGC---VVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVI 93

Query: 563 PAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLD-AAGAGAGRRGL 621
            A ++   G Y C AR    A   S PA +T+           +LD+        G   +
Sbjct: 94  TALNNHTVGRYQCVARMPAGAVA-SVPATVTLANLQ-----DFKLDVQHVIEVDEGNTAV 147

Query: 622 LLCRV-DSDPPARLQLLHKDRVVATS------LPSGGGCSTCGGCSPRMKVTKAPNLLRV 674
           + C + +S P A+++   K   +  S      +PSG                       +
Sbjct: 148 IACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGN----------------------L 185

Query: 675 EIHNPLLEEEGLYLCEASNAL-------GNASTSATFNGQATVLAI-----APSHTLQEG 722
           +I N   E+EG+Y C A N +       G++         A    I     A +  + +G
Sbjct: 186 QIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKG 245

Query: 723 TEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLP------VARTDAALYACRI 776
               L C  S      P   +W ++G     G  +T  LL        +  D+  Y C  
Sbjct: 246 QSLILECVAS---GIPPPRVTWAKDGSS-VTGYNKTRFLLSNLLIDTTSEEDSGTYRCMA 301

Query: 777 LTEAGAQLSTPVL--LSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPL-ALLALFHGE 833
               G   +  +L  + V  PP+     + L +  G  A   C V   P  ++L L +  
Sbjct: 302 DNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAV 361

Query: 834 HLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQV 893
            L+++              +   +   L V  +G  D G Y+C A N +GS++  +  Q+
Sbjct: 362 PLISSQ-------------RLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVV--QL 406

Query: 894 RGAWVQVSP 902
           R +   ++P
Sbjct: 407 RTSRPSITP 415


>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
            sapiens]
          Length = 2113

 Score = 91.7 bits (226), Expect = 6e-18
 Identities = 150/617 (24%), Positives = 234/617 (37%), Gaps = 86/617 (13%)

Query: 903  SPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQ-----AGA 957
            S E+  G  V L C   +G P   + RW +DG+PL   +  T R   +T++      +G 
Sbjct: 294  SQEVWAGHTVELPCTA-SGYPI-PAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSGT 351

Query: 958  YHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTL-MDTGPGRLGLLLCRVDSDPPAQLR 1016
            Y C+     + T   A    + +   P HVTLT   + TG G   +L C +   P   +R
Sbjct: 352  YICEV----TNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIR 407

Query: 1017 LLHGDRLV----ASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNT 1072
                  LV    A +++G+                    L I  A     G Y C A+  
Sbjct: 408  WYRNTELVLPDEAISIRGLSNET----------------LLITSAQKSHSGAYQCFATR- 450

Query: 1073 LGQASASADFDAQAVN------VQVWPGATVREGQLVNLTCLVWTTHPAQLTYTW----- 1121
              +A  + DF   A+       V  +    V  G+  +L C      P  +T+       
Sbjct: 451  --KAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI 508

Query: 1122 YQDGQQRL------DAHSIPLPNVT---VRDATSYRCG----VGPPGRAPRLSRPITLDV 1168
             +DG  R       D  +I   NVT   +RD   YRC     VG      R++       
Sbjct: 509  VRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARIN------- 561

Query: 1169 LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLEL 1228
            +  P ++R    + +  G+  L+ C V   P   +       LL  +    V     L+L
Sbjct: 562  VRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKL 621

Query: 1229 RGPQP-RDEGFYSCSAR-SPLGQANTSLELRLEGVRVILAPEAAVPE--GAPITVTCADP 1284
               Q   DEG Y CS    P    + S+ + ++ V  ++ P    P   G  + + C   
Sbjct: 622  TDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVK-VPPLIQPFEFPPASIGQLLYIPCVVS 680

Query: 1285 AAHAPTLYTWYHNGRWLQEGPA---------ASLSFLVATRAHAGAYSCQAQDAQGTRSS 1335
            +   P   TW  +G+ +  G           +SL     +  H G Y+C A +A  T  S
Sbjct: 681  SGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAAT-VS 739

Query: 1336 RPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSL 1395
            R   L V   P+  V  + +D       V+ C+VD  PP ++   H  K        H +
Sbjct: 740  RERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKH-AKGSGNPQQYHPV 798

Query: 1396 ASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGS-ISTIGRLQVE-GARVVAEPGL 1453
               TG +Q+  N+  L    +      Y+C A N +G+ IS    L V+  A + + P  
Sbjct: 799  PL-TGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNT 857

Query: 1454 DVP-EGAALNLSCRLLG 1469
             +  +G A  L+C   G
Sbjct: 858  TIAIKGHAKELNCTARG 874



 Score = 85.1 bits (209), Expect = 5e-16
 Identities = 164/778 (21%), Positives = 283/778 (36%), Gaps = 105/778 (13%)

Query: 303  YTCQAENGVGSLVSPPISLHIFMAE---VQVSPAGPILENQTVTLVCNTPNEAPSDLRY- 358
            Y C AEN  G + SP I +     E   V+V     +  N  V   C  P+     +   
Sbjct: 161  YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAV-FKCLIPSSVQEYVSVV 219

Query: 359  SWYKNHVLLEDAHSHTLRLH-------LATRADTGFYFCEVQNVHGSE--RSGPVSVVVN 409
            SW K+ V +   H   +  H       +        Y C  ++ +  E  +S    + V 
Sbjct: 220  SWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVT 279

Query: 410  HPP--LTPVLTAF--LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRF 465
             P   +  +L  F   E  AG    L C+    P+  +     G  L +   DS  + R 
Sbjct: 280  DPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPA---DSRWTKRI 336

Query: 466  SGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATST-LDFHANAARLLISP-AAEVVE 523
            +G        L I DL   DSG Y C  TN+ G+A +T +    +   + ++P   +   
Sbjct: 337  TG--------LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGI 388

Query: 524  GQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSS--------LLLPAASSTDAGSYHC 575
            G  V LSC   L+ +P+    WY N  L+      S        LL+ +A  + +G+Y C
Sbjct: 389  GSTVILSC--ALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQC 446

Query: 576  RARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635
             A      +   +   L    P    +F+ ++         G +  L+C     PP  + 
Sbjct: 447  FATRKAQTAQDFAIIALEDGTPRIVSSFSEKV------VNPGEQFSLMCAAKGAPPPTVT 500

Query: 636  LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695
                D  +       G   T      +  ++    +  + +  P + + G+Y C A N +
Sbjct: 501  WALDDEPIVRD----GSHRT-----NQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLV 551

Query: 696  GNASTSATFN--GQATVLAIAPSHTLQEGTEANLTCNVSREAAGSP-ANFSWFRNGVLWA 752
            G+A   A  N  G  ++ A+  + T   G +  + C V     G P  +  W+++ +L  
Sbjct: 552  GSAEYQARINVRGPPSIRAMR-NITAVAGRDTLINCRV----IGYPYYSIKWYKDALLLP 606

Query: 753  QGPLE------TVTLLPVAR-TDAALYACRILTEAGAQLSTPVLLSVLYPP-----DRPK 800
                +      T+ L  V +  D   Y C +L +    +S  V ++V  PP     + P 
Sbjct: 607  DNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPP 666

Query: 801  LSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLK 860
             S       G +    C V S  + +   +  +       G  + S      +++     
Sbjct: 667  ASI------GQLLYIPCVVSSGDMPIRITWRKD-------GQVIISGSGVTIESKEFMSS 713

Query: 861  LEVRELGLGDSGSYRCEATNVLG--SSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQV 918
            L++  + L  +G+Y C A+N     S    L  +V   +V    + +   G+A VL+C V
Sbjct: 714  LQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSV 773

Query: 919  HTGVPEGTSYRWYR-DGQP-----------LQESTSATLRFAAITLTQAGAYHCQAQAPG 966
                P    ++  +  G P           +Q   +++L    +     G Y CQA    
Sbjct: 774  DGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQAS--N 831

Query: 967  SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLV 1024
               T ++  + L V       +         G    L C    + P  +R   GD ++
Sbjct: 832  GVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVI 889



 Score = 68.6 bits (166), Expect = 5e-11
 Identities = 128/550 (23%), Positives = 208/550 (37%), Gaps = 84/550 (15%)

Query: 96  RVCNLLLKDLQPEDSGSYNFRFEISEV-NRWSDVKGTLVTVTEEPRVPTIASPVELLE-- 152
           R+  L + DL+ EDSG+Y     I EV N +   + T + +  +P   T+ +P +L    
Sbjct: 335 RITGLTISDLRTEDSGTY-----ICEVTNTFGSAEATGILMVIDPLHVTL-TPKKLKTGI 388

Query: 153 GTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHG 212
           G+ V  +C+   +    +  ++W        +    +     G+ + ETL +  + + H 
Sbjct: 389 GSTVILSCA---LTGSPEFTIRWYRN---TELVLPDEAISIRGLSN-ETLLITSAQKSHS 441

Query: 213 RILRCQLSVANHRAQSEIHLQVKYAPKGV-KILLSPSGRNILPGELVTLTCQVNSSYP-- 269
              +C    A  +AQ+     +     G  +I+ S S + + PGE  +L C    + P  
Sbjct: 442 GAYQC---FATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPT 498

Query: 270 ---AVSSIKWLKDG------VRLQTKTGVLHL----PQAAWSDAGVYTCQAENGVGSLVS 316
              A+     ++DG        +   T + H+    PQ    D GVY C A N VGS   
Sbjct: 499 VTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQI--RDGGVYRCTARNLVGSAE- 555

Query: 317 PPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDL------RYSWYKNHVLLEDA 370
                  + A + V     I   + +T V          +         WYK+ +LL D 
Sbjct: 556 -------YQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDN 608

Query: 371 H------SHTLRL-HLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLET 423
           H      + TL+L  +    D G Y C V        S  V V V  PPL      F   
Sbjct: 609 HRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPF-EFPPA 667

Query: 424 QAGLVGILHCSVVSEPL-ATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLE 482
             G +  + C V S  +   +     G ++ S SG +  S  F  +       L+I  + 
Sbjct: 668 SIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSS-------LQISSVS 720

Query: 483 ETDSGEYKCSATNSLGNATSTLDFHANA-ARLLISP-AAEVVEGQAVTLSCRSGLSPTPD 540
              +G Y C A+N+    +           R ++ P   + + G+A  L+C     P P 
Sbjct: 721 LKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPK 780

Query: 541 ARFSWYLNGA-------------LLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPS 587
             +  +  G+              +   P SSLL+      D G Y C+A +G   +  S
Sbjct: 781 VMWK-HAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNG-VGTDIS 838

Query: 588 SPAVLTVLYP 597
               LTV  P
Sbjct: 839 KSMFLTVKIP 848



 Score = 68.2 bits (165), Expect = 7e-11
 Identities = 139/683 (20%), Positives = 239/683 (34%), Gaps = 92/683 (13%)

Query: 250 RNILPGELVTLTCQVNSSYPAVSSIKWLKDG------VRLQTKTGVLHLPQAAWSDAGVY 303
           + +  G  V L C   S YP + +I+WLKDG       R   +   L +      D+G Y
Sbjct: 295 QEVWAGHTVELPCTA-SGYP-IPAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSGTY 352

Query: 304 TCQAENGVGSLVSPPISLHIFMAEVQVSPAG-PILENQTVTLVCNTPNEAPSDLRYSWYK 362
            C+  N  GS  +  I + I    V ++P         TV L C         +R  WY+
Sbjct: 353 ICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIR--WYR 410

Query: 363 NH--VLLEDAHS------HTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLT 414
           N   VL ++A S       TL +  A ++ +G Y C       ++ +   +++       
Sbjct: 411 NTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFA--TRKAQTAQDFAIIALEDGTP 468

Query: 415 PVLTAFLE--TQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPN 472
            ++++F E     G    L C+    P  T+  +     +      S  + +++ + G  
Sbjct: 469 RIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDG--SHRTNQYTMSDGTT 526

Query: 473 SLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANA-ARLLISPAAEVVEGQAVTLSC 531
              + +   +  D G Y+C+A N +G+A      +      +        V G+   ++C
Sbjct: 527 ISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINC 586

Query: 532 RSGLSPTPDARFSWYLNGALLHEG-------PGSSLLLPAASSTDAGSYHCRARDGHSAS 584
           R  +   P     WY +  LL +         G+  L       D G Y C        S
Sbjct: 587 R--VIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLS 644

Query: 585 GPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDS-DPPARLQLLHKDRVV 643
              S  V   + P  QP        +   A  G+   + C V S D P R+      +V+
Sbjct: 645 ISQSVHVAVKVPPLIQP-------FEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVI 697

Query: 644 ATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSAT 703
                SG G          + +     +  ++I +  L+  G Y C ASNA    S    
Sbjct: 698 I----SGSG----------VTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRE-- 741

Query: 704 FNGQATVLAIAPSHTLQE-------GTEANLTCNVS-----------REAAGSPANFSWF 745
              +  ++ + P   +Q        G    L C+V             + +G+P  +   
Sbjct: 742 ---RQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPV 798

Query: 746 RNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP---PDRPKLS 802
                    P  ++ +  V   D   Y C+     G  +S  + L+V  P      P  +
Sbjct: 799 PLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTT 858

Query: 803 ALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSL--K 860
             +   +GH     CT       ++    G+    T + P          K   + +   
Sbjct: 859 IAI---KGHAKELNCTARGERPIIIRWEKGD----TVIDPDRVMRYAIATKDNGDEVVST 911

Query: 861 LEVRELGLGDSGSYRCEATNVLG 883
           L+++    GDS  + C A N  G
Sbjct: 912 LKLKPADRGDSVFFSCHAINSYG 934



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 137/621 (22%), Positives = 232/621 (37%), Gaps = 88/621 (14%)

Query: 1065 YICEASNTLGQASASADFDAQAV-----NVQVWPGATVREGQLVNLTCLVWTTHPAQLTY 1119
            Y C A N  G+   S +   +AV      V+V    ++R G +    CL+ ++    ++ 
Sbjct: 161  YFCTAENAAGKIR-SPNIRVKAVFREPYTVRVEDQRSMR-GNVAVFKCLIPSSVQEYVSV 218

Query: 1120 -TWYQDGQQRLDAH--------SIPLPNVTVRDATS-YRC-------GVGPPGRAPRLSR 1162
             +W +D    +  H         + + +V   DA S YRC       G        RLS 
Sbjct: 219  VSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS- 277

Query: 1163 PITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPN 1222
             +T      P  L   +  E   G    + CT    P   +     GR L + +  +   
Sbjct: 278  -VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRI 336

Query: 1223 TLRLELRGPQPRDEGFYSCSARSPLGQAN-TSLELRLEGVRVILAPEAAVPE-GAPITVT 1280
            T  L +   +  D G Y C   +  G A  T + + ++ + V L P+      G+ + ++
Sbjct: 337  T-GLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILS 395

Query: 1281 CADPAAHAPTLYTWYHNGRWLQEGPAASLSFLV--------ATRAHAGAYSCQAQDAQGT 1332
            CA   +   T+  WY N   +    A S+  L         A ++H+GAY C A     T
Sbjct: 396  CALTGSPEFTI-RWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFA-----T 449

Query: 1333 RSSRPAALQVLYAPQDA---VLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHDGKVLA 1387
            R ++ A    + A +D    ++SSF +          + C     PP  +  + D + + 
Sbjct: 450  RKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIV 509

Query: 1388 TS----SGVHSLASGT--GHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQ 1441
                  +  ++++ GT   H+ V    +R            Y CTA+NL+GS     R+ 
Sbjct: 510  RDGSHRTNQYTMSDGTTISHMNVTGPQIR--------DGGVYRCTARNLVGSAEYQARIN 561

Query: 1442 VEGARVV-AEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRL---HAEPV---P 1494
            V G   + A   +    G    ++CR++G P      +  W+ +   L   H + V    
Sbjct: 562  VRGPPSIRAMRNITAVAGRDTLINCRVIGYP----YYSIKWYKDALLLPDNHRQVVFENG 617

Query: 1495 TLAFTHVARAQ-AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGIL- 1552
            TL  T V +    G Y C   +    + S  V + V  PP    +  F  P   +  +L 
Sbjct: 618  TLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPP---LIQPFEFPPASIGQLLY 674

Query: 1553 -DCRVDSEPLA-SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGE 1610
              C V S  +   +T     +++ S       ++  +  L         I ++     G 
Sbjct: 675  IPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSL--------QISSVSLKHNGN 726

Query: 1611 YICSASNVLGSASTSTYFGVR 1631
            Y C ASN   + S      VR
Sbjct: 727  YTCIASNAAATVSRERQLIVR 747



 Score = 61.2 bits (147), Expect = 8e-09
 Identities = 117/524 (22%), Positives = 182/524 (34%), Gaps = 57/524 (10%)

Query: 1052 LEIHGAMLEDEGVYICEASNTLGQASASADFDA-QAVNVQVWPGATVRE-GQLVNLTCLV 1109
            L I     ED G YICE +NT G A A+        ++V + P       G  V L+C +
Sbjct: 339  LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCAL 398

Query: 1110 WTTHPAQLTYTWYQDGQQRLDAHSIP---LPNVTVRDATSYRCGVGP----PGRAPRLSR 1162
              T   + T  WY++ +  L   +I    L N T+   ++ +   G       R  + ++
Sbjct: 399  --TGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQ 456

Query: 1163 PITLDVLY--APRNLRLTYLLESHGGQLALVLCTVDSRPPAQLAL-----------SHAG 1209
               +  L    PR +        + G+   ++C     PP  +             SH  
Sbjct: 457  DFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRT 516

Query: 1210 RLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEA 1269
                 S   ++ +   + + GPQ RD G Y C+AR+ +G A     + + G   I A   
Sbjct: 517  NQYTMSDGTTISH---MNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRN 573

Query: 1270 AVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPA------ASLSFL-VATRAHAGAY 1322
                    T+       +      WY +   L +          +L    V      G Y
Sbjct: 574  ITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEY 633

Query: 1323 SCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDS-EPPAELALSH 1381
             C          S+   + V   P       F  +    +  I C V S + P  +    
Sbjct: 634  LCSVLIQPQLSISQSVHVAVKVPPLIQPFE-FPPASIGQLLYIPCVVSSGDMPIRITWRK 692

Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRL 1440
            DG+V+ + SGV         ++       LQ+  V    +  Y C A N   ++S   +L
Sbjct: 693  DGQVIISGSGVT--------IESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQL 744

Query: 1441 QVE-GARVVAEPG-LDVPEGAALNLSCRLLGGPGPVGNSTFA-WFWNDRRLHAEPVP--- 1494
             V    R V +P   D   G A  L+C + G P P      A    N ++ H  P+    
Sbjct: 745  IVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRI 804

Query: 1495 ------TLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYP 1532
                  +L   HV     G Y C A    G   S  + L V  P
Sbjct: 805  QILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIP 848



 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 69/281 (24%), Positives = 108/281 (38%), Gaps = 47/281 (16%)

Query: 171 VRLQWQGQDPA----RSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRA 226
           +R+ W+           VT  S++F       + +L ++     H     C  S A    
Sbjct: 686 IRITWRKDGQVIISGSGVTIESKEF-------MSSLQISSVSLKHNGNYTCIASNAAATV 738

Query: 227 QSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTK 286
             E  L V+  P+ V   + P+ ++ + G+   L C V+   P     K  K     Q  
Sbjct: 739 SRERQLIVRVPPRFV---VQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQY 795

Query: 287 -----TGVLH-LPQAAW-------SDAGVYTCQAENGVGSLVSPPISLHI-FMAEVQVSP 332
                TG +  LP ++         D G Y CQA NGVG+ +S  + L +   A +   P
Sbjct: 796 HPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHP 855

Query: 333 AGPI-LENQTVTLVCNTPNEAPSDLRYSWYKNHVLLE---------------DAHSHTLR 376
              I ++     L C    E P  +R  W K   +++               D    TL+
Sbjct: 856 NTTIAIKGHAKELNCTARGERPIIIR--WEKGDTVIDPDRVMRYAIATKDNGDEVVSTLK 913

Query: 377 LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVL 417
           L  A R D+ F+ C   N +G +R G + + V  PP  P L
Sbjct: 914 LKPADRGDSVFFSCHAINSYGEDR-GLIQLTVQEPPDPPEL 953



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 71/331 (21%), Positives = 109/331 (32%), Gaps = 34/331 (10%)

Query: 1332 TRSSRPAALQVLYAPQD--AVLSSFRDSR--ARSMAVIQCTVDSEPPAELALSHDGKVLA 1387
            TR S  A L V    +    +L  F      A     + CT    P   +    DG+ L 
Sbjct: 268  TRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLP 327

Query: 1388 TSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQV-EGA 1445
              S      +G            L + D+   D  TY+C   N  GS    G L V +  
Sbjct: 328  ADSRWTKRITG------------LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPL 375

Query: 1446 RVVAEPG-LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPV--------PTL 1496
             V   P  L    G+ + LSC L G P      T  W+ N   +  +           TL
Sbjct: 376  HVTLTPKKLKTGIGSTVILSCALTGSP----EFTIRWYRNTELVLPDEAISIRGLSNETL 431

Query: 1497 AFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRV 1556
              T   ++ +G Y C A      A    ++      P+  +         G +  L C  
Sbjct: 432  LITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAA 491

Query: 1557 DSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSAS 1616
               P  ++T  L    +      G+       +        +++   +  D G Y C+A 
Sbjct: 492  KGAPPPTVTWALDDEPIVRD---GSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTAR 548

Query: 1617 NVLGSASTSTYFGVRALHRLHQFQQLLWVLG 1647
            N++GSA       VR    +   + +  V G
Sbjct: 549  NLVGSAEYQARINVRGPPSIRAMRNITAVAG 579



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 123/573 (21%), Positives = 201/573 (35%), Gaps = 80/573 (13%)

Query: 1109 VWTTHPAQLTYT----------WYQDGQQRLDAHS--------IPLPNVTVRDATSYRCG 1150
            VW  H  +L  T          W +DG+  L A S        + + ++   D+ +Y C 
Sbjct: 297  VWAGHTVELPCTASGYPIPAIRWLKDGRP-LPADSRWTKRITGLTISDLRTEDSGTYICE 355

Query: 1151 VGPP-GRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAG 1209
            V    G A      + +D L+     +    L++  G   ++ C +   P   +      
Sbjct: 356  VTNTFGSAEATGILMVIDPLHVTLTPKK---LKTGIGSTVILSCALTGSPEFTIRWYRNT 412

Query: 1210 RLLASSTAASVPNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG--VRVIL 1265
             L+    A S+       L +   Q    G Y C A      A     + LE    R++ 
Sbjct: 413  ELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVS 472

Query: 1266 A-PEAAVPEGAPITVTCADPAAHAPTLYTWY-----------HNGRWLQEGPAASLSFLV 1313
            +  E  V  G   ++ CA   A  PT+ TW            H           ++S + 
Sbjct: 473  SFSEKVVNPGEQFSLMCAAKGAPPPTV-TWALDDEPIVRDGSHRTNQYTMSDGTTISHMN 531

Query: 1314 ATRAH---AGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVD 1370
             T       G Y C A++  G+   + A + V   P    + +      R   +I C V 
Sbjct: 532  VTGPQIRDGGVYRCTARNLVGSAEYQ-ARINVRGPPSIRAMRNITAVAGRD-TLINCRVI 589

Query: 1371 SEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDT--YVCTA- 1427
              P   +    D  +L  +           H QV      L++ DV  G D   Y+C+  
Sbjct: 590  GYPYYSIKWYKDALLLPDN-----------HRQVVFENGTLKLTDVQKGMDEGEYLCSVL 638

Query: 1428 -QNLLGSISTIGRLQVEGARVVAEPGLDVPE--GAALNLSCRLLGGPGPVGNSTFAWFWN 1484
             Q  L SIS    + V+   ++ +P    P   G  L + C +  G  P+      W  +
Sbjct: 639  IQPQL-SISQSVHVAVKVPPLI-QPFEFPPASIGQLLYIPCVVSSGDMPI---RITWRKD 693

Query: 1485 DRRLHA---------EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKT 1535
             + + +         E + +L  + V+    G Y C+A     A  S    L V  PP+ 
Sbjct: 694  GQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIAS-NAAATVSRERQLIVRVPPRF 752

Query: 1536 PTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNA 1595
                   +   G  G+L+C VD  P   +            Q    P    I +L + + 
Sbjct: 753  VVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSL 812

Query: 1596 LRVDIEALRPSDQGEYICSASNVLGSASTSTYF 1628
            L   I  +   D G Y+C ASN +G+  + + F
Sbjct: 813  L---IRHVLEEDIGYYLCQASNGVGTDISKSMF 842


>gi|7657570 sialic acid binding Ig-like lectin 7 isoform 1 [Homo
           sapiens]
          Length = 467

 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 86/344 (25%), Positives = 143/344 (41%), Gaps = 39/344 (11%)

Query: 16  AGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVP-DGITAIWYY---DYSGQRQVVS 71
           + +  + ++    V   +G C+ + C FS+P D +   D +   W+    D S +  V +
Sbjct: 21  SNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDPVHGYWFRAGNDISWKAPVAT 80

Query: 72  HSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGT 131
           ++     V+   R R   +G+P+ + C L ++D +  D+G Y FR E   + +W+     
Sbjct: 81  NNP-AWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGRYFFRMEKGNI-KWNYKYDQ 138

Query: 132 L-VTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQ-EQVRLQWQGQ--DPARSVTFN 187
           L V VT     P I  P  L  G   +  CS P+ C Q     + W G    P    T  
Sbjct: 139 LSVNVTALTHRPNILIPGTLESGCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTR 198

Query: 188 SQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSV--ANHRAQSEIHLQVKYAPKGVKI-- 243
           S             L +    Q HG  L CQ+++  A       I L V Y P+ + +  
Sbjct: 199 S-----------SVLTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTV 247

Query: 244 ----------LLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLP 293
                     L + S  ++L G+ + L C V+S+ PA  S  W    +     +  L L 
Sbjct: 248 FQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQPSNPLVLE 307

Query: 294 -QAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPI 336
            Q    D G +TC+A+N +G   S  +SL++ + +       P+
Sbjct: 308 LQVHLGDEGEFTCRAQNSLG---SQHVSLNLSLQQEYTGKMRPV 348



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 75/260 (28%), Positives = 101/260 (38%), Gaps = 45/260 (17%)

Query: 1035 EGSSPRLHVAVAPNTLR--LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVW 1092
            E +  R H+   P T    L I  A + D G Y        G    +  +D  +VNV   
Sbjct: 89   EETRDRFHLLGDPQTKNCTLSIRDARMSDAGRYFFRMEK--GNIKWNYKYDQLSVNVTAL 146

Query: 1093 --------PGATVREGQLVNLTCLV-WTTHPAQLTY-TWYQDGQQRLDAHS--------I 1134
                    PG T+  G   NLTC V W          +W       L   +        I
Sbjct: 147  THRPNILIPG-TLESGCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTRSSVLTLI 205

Query: 1135 PLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYL-------------- 1180
            P P       TS  C V  PG     +R I L+V Y P+NL +T                
Sbjct: 206  PQPQ---HHGTSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNSS 262

Query: 1181 -LESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFY 1239
             L    GQ   ++C VDS PPA+L+ +     L  S  +   N L LEL+     DEG +
Sbjct: 263  SLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQPS---NPLVLELQ-VHLGDEGEF 318

Query: 1240 SCSARSPLGQANTSLELRLE 1259
            +C A++ LG  + SL L L+
Sbjct: 319  TCRAQNSLGSQHVSLNLSLQ 338



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 57/196 (29%), Positives = 81/196 (41%), Gaps = 43/196 (21%)

Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPLE-------TVTLLPVARTDA 769
           TL+ G   NLTC+V      G+P   SW    V     PL         +TL+P  +   
Sbjct: 157 TLESGCFQNLTCSVPWACEQGTPPMISWMGTSV----SPLHPSTTRSSVLTLIPQPQHHG 212

Query: 770 ALYACRI-LTEAGAQLSTPVLLSVLYPPDRPKL---------------SALLDMGQGHMA 813
               C++ L  AG   +  + L+V YPP    +               S+ L + +G   
Sbjct: 213 TSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSL 272

Query: 814 LFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGS 873
             +C VDS P A L+        + +L P  PS          N L LE+ ++ LGD G 
Sbjct: 273 RLVCAVDSNPPARLSWTWR----SLTLYPSQPS----------NPLVLEL-QVHLGDEGE 317

Query: 874 YRCEATNVLGSSNTSL 889
           + C A N LGS + SL
Sbjct: 318 FTCRAQNSLGSQHVSL 333



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 64/259 (24%), Positives = 100/259 (38%), Gaps = 50/259 (19%)

Query: 855  EANSLKLEVRELGLGDSGSY--RCEATNVLGSSNTSLFFQVRGAWVQVSPSPE------L 906
            +  +  L +R+  + D+G Y  R E  N+  +     + Q+      ++  P       L
Sbjct: 102  QTKNCTLSIRDARMSDAGRYFFRMEKGNIKWNYK---YDQLSVNVTALTHRPNILIPGTL 158

Query: 907  QEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYH-----CQ 961
            + G    L+C V     +GT       G  +     +T R + +TL     +H     CQ
Sbjct: 159  ESGCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQ 218

Query: 962  AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL---------------LLCR 1006
               PG+  T+    I L+VSY P+++T+T     G     L               L+C 
Sbjct: 219  VTLPGAGVTTNRT-IQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCA 277

Query: 1007 VDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYI 1066
            VDS+PPA+L                      S  L+ +   N L LE+    L DEG + 
Sbjct: 278  VDSNPPARLSW-----------------TWRSLTLYPSQPSNPLVLELQ-VHLGDEGEFT 319

Query: 1067 CEASNTLGQASASADFDAQ 1085
            C A N+LG    S +   Q
Sbjct: 320  CRAQNSLGSQHVSLNLSLQ 338



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 35/126 (27%), Positives = 49/126 (38%), Gaps = 31/126 (24%)

Query: 592 LTVLYPPRQPTFTTRLDLDAAGAGAGRRGLL----------LCRVDSDPPARLQLLHKDR 641
           L V YPP+  T T       A    G    L          +C VDS+PPARL    +  
Sbjct: 234 LNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSL 293

Query: 642 VVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTS 701
            +  S PS                   P +L +++H   L +EG + C A N+LG+   S
Sbjct: 294 TLYPSQPSN------------------PLVLELQVH---LGDEGEFTCRAQNSLGSQHVS 332

Query: 702 ATFNGQ 707
              + Q
Sbjct: 333 LNLSLQ 338



 Score = 40.0 bits (92), Expect = 0.019
 Identities = 39/132 (29%), Positives = 52/132 (39%), Gaps = 33/132 (25%)

Query: 1511 CLAELP-TGAAASAPVMLRVLYPPKTPTMMVFVEPEG----------------GLRGILD 1553
            C   LP  G   +  + L V YPP+  T+ VF + EG                G    L 
Sbjct: 217  CQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVF-QGEGTASTALGNSSSLSVLEGQSLRLV 275

Query: 1554 CRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYIC 1613
            C VDS P A L+    S  +  SQP            ++P  L + +      D+GE+ C
Sbjct: 276  CAVDSNPPARLSWTWRSLTLYPSQP------------SNPLVLELQVHL---GDEGEFTC 320

Query: 1614 SASNVLGSASTS 1625
             A N LGS   S
Sbjct: 321  RAQNSLGSQHVS 332



 Score = 38.9 bits (89), Expect = 0.043
 Identities = 35/141 (24%), Positives = 54/141 (38%), Gaps = 30/141 (21%)

Query: 1309 LSFLVATRAHAGAYSCQAQ-DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV--- 1364
            L+ +   + H  + +CQ      G  ++R   L V Y PQ+  ++ F+     S A+   
Sbjct: 202  LTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNS 261

Query: 1365 ------------IQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQ 1412
                        + C VDS PPA L+ +     L  S                 N L L+
Sbjct: 262  SSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQ--------------PSNPLVLE 307

Query: 1413 VQDVPAGDDTYVCTAQNLLGS 1433
            +Q     +  + C AQN LGS
Sbjct: 308  LQVHLGDEGEFTCRAQNSLGS 328



 Score = 31.6 bits (70), Expect = 6.9
 Identities = 29/103 (28%), Positives = 43/103 (41%), Gaps = 4/103 (3%)

Query: 516 SPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEG-PGSSLLLP-AASSTDAGSY 573
           S +  V+EGQ++ L C   +   P AR SW      L+   P + L+L       D G +
Sbjct: 261 SSSLSVLEGQSLRLVC--AVDSNPPARLSWTWRSLTLYPSQPSNPLVLELQVHLGDEGEF 318

Query: 574 HCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGA 616
            CRA++   +   S    L   Y  +    +  L     GAGA
Sbjct: 319 TCRAQNSLGSQHVSLNLSLQQEYTGKMRPVSGVLLGAVGGAGA 361


>gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens]
          Length = 708

 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 119/437 (27%), Positives = 177/437 (40%), Gaps = 70/437 (16%)

Query: 681  LEEEGLYLCEASNALGNASTSATFN----GQATVLAIAPSHTLQEGTEANLTCNVSREAA 736
            LE+E  Y C+A+ A G  S  A  +     +A  +   PS +L  G  ANLTC    +A 
Sbjct: 95   LEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDAR 153

Query: 737  GSPANFSWFRNGVLW-------------AQGPLE-TVTLLPVARTDAALYACRILTEA-G 781
             +P    WFR+GVL                G +E T+TL P +  D A + CR  ++A  
Sbjct: 154  PTP-ELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALP 212

Query: 782  AQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLG 841
                T + LS+ YPP+    ++   + +G   +F+C   ++P          +  A    
Sbjct: 213  TGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT------GYRWAKGGS 266

Query: 842  PQVPSHG-RFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR-GAWVQ 899
            P + + G R +  A+A+ L   V            CE +N +GS+N S    V  G  +Q
Sbjct: 267  PVLGARGPRLEVVADASFLTEPVS-----------CEVSNAVGSANRSTALDVLFGPILQ 315

Query: 900  VSPSP-ELQEGQAVVLSCQVHTG-VPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGA 957
              P P  +  G+    SC      +P  T   W R G      + ATLR  ++    AG 
Sbjct: 316  AKPEPVSVDVGEDASFSCAWRGNPLPRVT---WTRRGGAQVLGSGATLRLPSVGPEDAGD 372

Query: 958  YHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRL---GLLLCRVDSDPPAQ 1014
            Y C+A+A  S     AA   L V+  P    + T + + P  L     L C V + P   
Sbjct: 373  YVCRAEAGLSGLRGGAAEARLTVNAPP----VVTALHSAPAFLRGPARLQCLVFASPAP- 427

Query: 1015 LRLLHGDRLVASTLQGV--GGPEG-------SSPRLHVAVAPNTLR-LEIHGAMLED-EG 1063
                  D +V S  +G    G +G        +P     + P  +  L I G    D   
Sbjct: 428  ------DAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSR 481

Query: 1064 VYICEASNTLGQASASA 1080
             + C A N LG+  A A
Sbjct: 482  SFNCSARNRLGEGGAQA 498



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 96/400 (24%), Positives = 150/400 (37%), Gaps = 72/400 (18%)

Query: 244 LLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV-------------- 289
           L  P    +L GE   L C + + +  V   +W K G+ L  +  +              
Sbjct: 27  LQQPEDLVVLLGEEARLPCALGAYWGLV---QWTKSGLALGGQRDLPGWSRYWISGNAAN 83

Query: 290 ----LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA----EVQVSPAGPILENQT 341
               LH+      D   Y CQA      L S P  LH+ +     +V   P+  ++    
Sbjct: 84  GQHDLHIRPVELEDEASYECQATQA--GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVP 141

Query: 342 VTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH--------------TLRLHLATRADTGF 387
             L C +  +A       W+++ VLL+ A  H              TL L   +  D   
Sbjct: 142 ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGAT 201

Query: 388 YFCEVQN-VHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLS 446
           + C  ++    + R   +++ + +PP   +  +    Q G   I  C   ++P  T    
Sbjct: 202 FVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT---- 257

Query: 447 HGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDF 506
             G+  A        SP   G  GP   RLE+       +    C  +N++G+A      
Sbjct: 258 --GYRWAKGG-----SPVL-GARGP---RLEVVADASFLTEPVSCEVSNAVGSAN----- 301

Query: 507 HANAARLLISPAAE-------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSS 559
            + A  +L  P  +       V  G+  + SC    +P P  R +W   G     G G++
Sbjct: 302 RSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLP--RVTWTRRGGAQVLGSGAT 359

Query: 560 LLLPAASSTDAGSYHCRARDGHSA-SGPSSPAVLTVLYPP 598
           L LP+    DAG Y CRA  G S   G ++ A LTV  PP
Sbjct: 360 LRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPP 399



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 115/477 (24%), Positives = 165/477 (34%), Gaps = 67/477 (14%)

Query: 861  LEVRELGLGDSGSYRCEATNV-LGSSNTSLFFQVRGAWVQV--SPSPELQEGQAVVLSCQ 917
            L +R + L D  SY C+AT   L S    L   V     QV   PS  L  G    L+C+
Sbjct: 88   LHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCR 147

Query: 918  VHTGVPEGTSYRWYRDGQPLQEST--------------SATLRFAAITLTQAGAYHCQAQ 963
                        W+RDG  L  +T               +TL     +      + C+A+
Sbjct: 148  SRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRAR 207

Query: 964  APGSATTSLAAPISLHVSYAPRHVTLTTLMDT-GPGRLGLLLCRVDSDPPAQ-LRLLHGD 1021
            +  +  T     I+L + Y P  VTL+    T   G   + LC+  + PP    R   G 
Sbjct: 208  SQ-ALPTGRDTAITLSLQYPP-EVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKG- 264

Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081
                S + G  G     PRL V    + L   +            CE SN +G A+ S  
Sbjct: 265  ---GSPVLGARG-----PRLEVVADASFLTEPVS-----------CEVSNAVGSANRSTA 305

Query: 1082 FDAQ-AVNVQVWP-GATVREGQLVNLTCLVWTTHP-AQLTYTWYQDGQQRLDAHSIPLPN 1138
             D      +Q  P   +V  G+  + +C  W  +P  ++T+T     Q      ++ LP+
Sbjct: 306  LDVLFGPILQAKPEPVSVDVGEDASFSC-AWRGNPLPRVTWTRRGGAQVLGSGATLRLPS 364

Query: 1139 VTVRDATSYRC----------GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQL 1188
            V   DA  Y C          G     R    + P+   +  AP  LR    L+      
Sbjct: 365  VGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFAS 424

Query: 1189 ALVLCTVDSRPPAQLALSHAGRLLASSTAASV------PNTLR-LELRGPQPRD-EGFYS 1240
                  V S     L     GR L  +  A        P  +  L + G Q  D    ++
Sbjct: 425  PAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFN 484

Query: 1241 CSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN 1297
            CSAR+ LG+      L     R  L P   +  G     T          L  W H+
Sbjct: 485  CSARNRLGEGGAQASLG----RRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHS 537



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 111/483 (22%), Positives = 164/483 (33%), Gaps = 71/483 (14%)

Query: 1226 LELRGPQPRDEGFYSCSARSPLGQANTSLELRL----EGVRVILAPEAAVPEGAPITVTC 1281
            L +R  +  DE  Y C A +  G  +   +L +    E  +V+  P  ++  G P  +TC
Sbjct: 88   LHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 146

Query: 1282 ADPAAHAPT-LYTWYHNG----------RWLQEGPAAS----LSFLVATRAHAGAYSCQA 1326
                   PT    W+ +G            L+EG   S    L+    +      + C+A
Sbjct: 147  RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 206

Query: 1327 Q-DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKV 1385
            +  A  T       L + Y P+  + +S    +     +  C   ++PP           
Sbjct: 207  RSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT--------- 257

Query: 1386 LATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV-EG 1444
                   +  A G   V  AR      V D     +   C   N +GS +    L V  G
Sbjct: 258  ------GYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFG 311

Query: 1445 ARVVAEP-GLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPV---PTLAFTH 1500
              + A+P  + V  G   + SC   G P P       W    RR  A+ +    TL    
Sbjct: 312  PILQAKPEPVSVDVGEDASFSCAWRGNPLP----RVTW---TRRGGAQVLGSGATLRLPS 364

Query: 1501 VARAQAGMYHCLAELP----TGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRG--ILDC 1554
            V    AG Y C AE       G AA A + +        P +         LRG   L C
Sbjct: 365  VGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNA-----PPVVTALHSAPAFLRGPARLQC 419

Query: 1555 RVDSEPLASLTLHLGSRLVASSQPQGA------PAEPHIHVLASPNALRV-DIEALRPSD 1607
             V + P     +         +  QG       PA P       P  + V  I   + SD
Sbjct: 420  LVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPA-PESRGGLGPGLISVLHISGTQESD 478

Query: 1608 -QGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWR 1666
                + CSA N LG        G R L  L   + +  V      LL+++ G+  C  WR
Sbjct: 479  FSRSFNCSARNRLGEGGAQASLGRRDL--LPTVRIVAGVAAATTTLLMVITGVALC-CWR 535

Query: 1667 RRR 1669
              +
Sbjct: 536  HSK 538


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,691,363
Number of Sequences: 37866
Number of extensions: 3649134
Number of successful extensions: 21491
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 214
Number of HSP's successfully gapped in prelim test: 280
Number of HSP's that attempted gapping in prelim test: 10018
Number of HSP's gapped (non-prelim): 6409
length of query: 1709
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1593
effective length of database: 13,855,062
effective search space: 22071113766
effective search space used: 22071113766
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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