BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|13489095 sialoadhesin precursor [Homo sapiens] (1709 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|13489095 sialoadhesin precursor [Homo sapiens] 3435 0.0 gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 205 3e-52 gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 205 3e-52 gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 205 3e-52 gi|110349719 titin isoform N2-A [Homo sapiens] 201 5e-51 gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 185 3e-46 gi|157168355 CD22 molecule [Homo sapiens] 178 4e-44 gi|118572606 hemicentin 1 [Homo sapiens] 170 1e-41 gi|11225258 myelin associated glycoprotein isoform a precursor [... 143 1e-33 gi|18104957 myelin associated glycoprotein isoform b precursor [... 143 1e-33 gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 134 6e-31 gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact... 119 3e-26 gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 119 3e-26 gi|98986445 carcinoembryonic antigen-related cell adhesion molec... 109 3e-23 gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Ho... 108 6e-23 gi|31377639 sialic acid binding Ig-like lectin 10 [Homo sapiens] 108 6e-23 gi|144226847 obscurin-like 1 [Homo sapiens] 106 2e-22 gi|193794821 sialic acid binding Ig-like lectin 6 isoform 1 prec... 100 2e-20 gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Ho... 99 3e-20 gi|193794817 sialic acid binding Ig-like lectin 6 isoform 3 prec... 99 4e-20 gi|193794819 sialic acid binding Ig-like lectin 6 isoform 2 prec... 97 2e-19 gi|23943856 sialic acid binding Ig-like lectin 9 [Homo sapiens] 96 2e-19 gi|94538343 sialic acid binding Ig-like lectin 8 [Homo sapiens] 96 2e-19 gi|16506826 sialic acid binding immunoglobulin-like lectin-like ... 96 4e-19 gi|16506828 sialic acid binding immunoglobulin-like lectin-like ... 96 4e-19 gi|157694526 Fc receptor-like 5 [Homo sapiens] 93 3e-18 gi|15147240 brother of CDO [Homo sapiens] 92 4e-18 gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 92 6e-18 gi|7657570 sialic acid binding Ig-like lectin 7 isoform 1 [Homo ... 91 1e-17 gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens] 90 2e-17 >gi|13489095 sialoadhesin precursor [Homo sapiens] Length = 1709 Score = 3435 bits (8906), Expect = 0.0 Identities = 1709/1709 (100%), Positives = 1709/1709 (100%) Query: 1 MGFLPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWY 60 MGFLPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWY Sbjct: 1 MGFLPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWY 60 Query: 61 YDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEIS 120 YDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEIS Sbjct: 61 YDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEIS 120 Query: 121 EVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDP 180 EVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDP Sbjct: 121 EVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDP 180 Query: 181 ARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKG 240 ARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKG Sbjct: 181 ARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKG 240 Query: 241 VKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSDA 300 VKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSDA Sbjct: 241 VKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSDA 300 Query: 301 GVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSW 360 GVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSW Sbjct: 301 GVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSW 360 Query: 361 YKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF 420 YKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF Sbjct: 361 YKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF 420 Query: 421 LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRD 480 LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRD Sbjct: 421 LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRD 480 Query: 481 LEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPD 540 LEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPD Sbjct: 481 LEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPD 540 Query: 541 ARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQ 600 ARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQ Sbjct: 541 ARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQ 600 Query: 601 PTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCS 660 PTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCS Sbjct: 601 PTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCS 660 Query: 661 PRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQ 720 PRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQ Sbjct: 661 PRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQ 720 Query: 721 EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEA 780 EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEA Sbjct: 721 EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEA 780 Query: 781 GAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSL 840 GAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSL Sbjct: 781 GAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSL 840 Query: 841 GPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV 900 GPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV Sbjct: 841 GPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV 900 Query: 901 SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHC 960 SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHC Sbjct: 901 SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHC 960 Query: 961 QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020 QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG Sbjct: 961 QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020 Query: 1021 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA Sbjct: 1021 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080 Query: 1081 DFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVT 1140 DFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVT Sbjct: 1081 DFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVT 1140 Query: 1141 VRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPP 1200 VRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPP Sbjct: 1141 VRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPP 1200 Query: 1201 AQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG 1260 AQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG Sbjct: 1201 AQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG 1260 Query: 1261 VRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRAHAG 1320 VRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRAHAG Sbjct: 1261 VRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRAHAG 1320 Query: 1321 AYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALS 1380 AYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALS Sbjct: 1321 AYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALS 1380 Query: 1381 HDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRL 1440 HDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRL Sbjct: 1381 HDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRL 1440 Query: 1441 QVEGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTH 1500 QVEGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTH Sbjct: 1441 QVEGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTH 1500 Query: 1501 VARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEP 1560 VARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEP Sbjct: 1501 VARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEP 1560 Query: 1561 LASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620 LASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG Sbjct: 1561 LASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620 Query: 1621 SASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCKQSMGENSV 1680 SASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCKQSMGENSV Sbjct: 1621 SASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCKQSMGENSV 1680 Query: 1681 EMAFQKETTQLIDPDAATCETSTCAPPLG 1709 EMAFQKETTQLIDPDAATCETSTCAPPLG Sbjct: 1681 EMAFQKETTQLIDPDAATCETSTCAPPLG 1709 >gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] Length = 3874 Score = 205 bits (522), Expect = 3e-52 Identities = 356/1491 (23%), Positives = 543/1491 (36%), Gaps = 255/1491 (17%) Query: 259 TLTCQVNSSYPAVSSIKWLKDGV------RLQTKTG--VLHLPQAAWSDAGVYTCQAENG 310 T++ Q + V +I WL++G+ RLQ VL + A +DA Y C AEN Sbjct: 1671 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ 1730 Query: 311 VGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLR------YSWYKNH 364 GS +F VQV P L+ + VT + N+ P D+ +WYK+ Sbjct: 1731 AGSAEK------LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDS 1784 Query: 365 VLLEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSERS-GPVSVVV----NHPP 412 L +HTL+L A +D+G Y CE N G ++ +SV+V P Sbjct: 1785 QALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAP 1844 Query: 413 LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPN 472 P + + G +L C + P T+ G L R G Sbjct: 1845 RGPQDAVLV--RVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQ-------RTQALRGGQ 1895 Query: 473 SLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE---GQAVTL 529 RLEI++ + +D G Y C +N G A T +P E V G + L Sbjct: 1896 --RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVL 1953 Query: 530 SCRSGLSPTPDARFSWY-----LNGALLH--EGPGSSLLLPAASSTDAGSYHCRARDGHS 582 +C +S P +W + + +H G L L AG+Y C A + + Sbjct: 1954 TC--DVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA 2011 Query: 583 ASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRV 642 + V+ VL PR + + G+ L C D PP + L Sbjct: 2012 EA--RKDFVVAVLVAPRIRSSGVAREHHVL---EGQEVRLDCEADGQPPPDVAWLKDGSP 2066 Query: 643 VATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSA 702 + + GG S +K +A + G Y C A N G + Sbjct: 2067 LGQDMGPHLRFYLDGG-SLVLKGLRA-------------SDAGAYTCVAHNPAGEDARLH 2112 Query: 703 TFNGQATVLAIAPSHTLQEGTEAN---------LTCNVSREAAGSPANFSWFRNGV---- 749 T N + + P T+++G + + L V P + SW ++G+ Sbjct: 2113 TVN-----VLVPP--TIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL 2165 Query: 750 ---LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLD 806 G T+ + V DA ++ C + AG L V PP + D Sbjct: 2166 SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGV-ADRNFTLQVQVPPVLEPVEFQND 2224 Query: 807 --MGQGHMALFICTVDSRPLALLA-LFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863 + +G + C PL L++ + GE LL+ SL Q PS L++ Sbjct: 2225 VVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSL-EQGPS--------------LQL 2269 Query: 864 RELGLGDSGSYRCEATNVLGSSNTSLFFQV-RGAWVQVSPSP---ELQEGQAVVLSCQVH 919 +G GDSG+Y C A + G + V ++ S P L G + L C Sbjct: 2270 EAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 2329 Query: 920 TGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSA-----TTSLAA 974 G P+ + W++DGQ L + + + + AG Y C A++P A + A Sbjct: 2330 -GTPQ-PNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQA 2387 Query: 975 PISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034 P ++ PR V + PG+L +L C V+++P ++ H D +V Sbjct: 2388 PPNIVGPRGPRFV-----VGLAPGQL-VLECSVEAEPAPKI-TWHRDGIVL--------- 2431 Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG 1094 H L++ D G Y C A N G S A V++ Sbjct: 2432 ---QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSV-------AFRVEIHTV 2481 Query: 1095 ATVREGQ-----LVNLTCLVWTTH---PAQLTYTWYQDGQ---------QRLDAHSIPLP 1137 T+R G VN T L+ PA L +W +D + L S+ + Sbjct: 2482 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLV-SWRKDRVPLDPRSPRFEILPEGSLRIQ 2540 Query: 1138 NVTVRDATSYRC------GVGPPGRAPRLSRPITLDVLYAPRNLRLT------YLLESHG 1185 V +DA Y C G GR R+ P + +P NL LT E+ G Sbjct: 2541 PVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPA--IAPSPSNLTLTAHTPALLPCEASG 2598 Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARS 1245 LV+ D + A RLL S+ L L P P+D + C + Sbjct: 2599 SPKPLVVWWKDGQKLDFRLQQGAYRLLPSNA---------LLLTAPGPQDSAQFECVVSN 2649 Query: 1246 PLGQANTSLELRLEGVRVILAPEAA-------VPEGAPITVTCADPAAHAPTLYTWYHNG 1298 +G+A+ RL V V + P A V AP+ +TC APT+ +W G Sbjct: 2650 EVGEAH-----RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTV-SWSKAG 2703 Query: 1299 RWL-------QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVL 1351 L + P+ +L A HAG Y+C A+++ G + + L V +P L Sbjct: 2704 AQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPL 2762 Query: 1352 SSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRL 1411 S + A ++ C P + +G +AT GV + G +++A + Sbjct: 2763 PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVAT--GVSTQVLPGGQLRIAHAS--- 2817 Query: 1412 QVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAE--PGLDVPEGAALNLSCRLLG 1469 P Y+C A+N GS RL V+ V+ P L EG+ L C+ G Sbjct: 2818 -----PEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARG 2872 Query: 1470 GPGPVGNSTFAWFWN---------DRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAA 1520 P P N T W+ + + +P L ++ AG Y C AE G A Sbjct: 2873 SPEP--NIT----WDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRA 2926 Query: 1521 ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQG 1580 V L +L P T+ G R L C P + + R V Sbjct: 2927 RRR-VHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG---- 2981 Query: 1581 APAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631 V + A+ D G Y+C A N +G ++ V+ Sbjct: 2982 --------VSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 3024 Score = 202 bits (513), Expect = 3e-51 Identities = 373/1573 (23%), Positives = 580/1573 (36%), Gaps = 263/1573 (16%) Query: 194 TGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNIL 253 + VG L L A Q+ C V N + ++ L+V P+ P+ +++ Sbjct: 1023 SAVGRLLYLGQAQLAQEGTYTCECSNVVGN--SSQDLQLEVHVPPQIAGPREPPTQVSVV 1080 Query: 254 PGELVTLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTC 305 + TL C P ++ W +DG ++LQ + LH+ +A + G Y+C Sbjct: 1081 QDGVATLECNATGKPPP--TVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 1138 Query: 306 QAENGVGSLVSPPISLHIFMAEVQVSPAGPILE-----NQTVTLVCNTPNEAPSDLRYSW 360 AEN G L + + + P+ + +TL+C P +R W Sbjct: 1139 VAENLAGR-AERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIR--W 1195 Query: 361 YKNHVLL---EDAH----SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413 ++ + ED + L++ D+G Y C N G R SV V PP Sbjct: 1196 FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRN-FSVEVLVPPS 1254 Query: 414 --TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGP 471 L ++ G L C+V P L G LA GD+ H P Sbjct: 1255 IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR--GDAHHI-------SP 1305 Query: 472 NSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAE-------VVEG 524 + + L++ + +G Y C A N++G T A ++ A + V Sbjct: 1306 DGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVN 1365 Query: 525 QAVTLSCRSGLSPTPDARFSWYLNGALLHEG------PGS-SLLLPAASSTDAGSYHCRA 577 ++L C + P+P+ +W +GA PG+ L + A DAG Y C Sbjct: 1366 NPISLICEALAFPSPN--ITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVV 1423 Query: 578 RDGHSASGPSSPAVLTVLYPPR--QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635 + + + + VL PP + + + L C + PP ++ Sbjct: 1424 TNELGEAVKNYH--VEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIR 1481 Query: 636 LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695 +KD T S R++V LL+++ + + G YLC A+N Sbjct: 1482 W-YKDGQPVTP-------------SSRLQVLGEGRLLQIQPTQ--VSDSGRYLCVATNVA 1525 Query: 696 GNASTS--------------ATFNGQATVLA--------IAPSHTLQEGTEANLTCNVSR 733 G F+ +L+ + + E A L C+ + Sbjct: 1526 GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTN- 1584 Query: 734 EAAGSPANFSWFRNGVLWAQGPLETVTL------LPVARTD-AALYACRILTEAGAQLST 786 A P + +W+R + G +V +P+ R + A Y+C+ E G Sbjct: 1585 --AIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 1642 Query: 787 PVLLSVLYPP----DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGP 842 LL VL PP D +L + + C P+ ++ + S Sbjct: 1643 YELL-VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRL 1701 Query: 843 QVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSP 902 QV G+ L+V + D+ SY C A N GS+ F +R VQV P Sbjct: 1702 QVLEDGQV----------LQVSTAEVADAASYMCVAENQAGSAEK--LFTLR---VQVPP 1746 Query: 903 ---SPELQEGQAVV-----LSCQVHTGV-PEGTSYRWYRDGQPLQESTSA-------TLR 946 +L++ A++ L C VH PE T WY+D Q L TL+ Sbjct: 1747 RIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT---WYKDSQALSLGEEVFLLPGTHTLQ 1803 Query: 947 FAAITLTQAGAYHCQA-QAPG--SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLL 1003 L+ +G Y C+A A G L+ + APR L+ G +L Sbjct: 1804 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDK--AVL 1861 Query: 1004 LCRVDSDP-PAQLRLLHGDRLV-ASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061 C D+ P P G LV A Q + G + RLEI A + D Sbjct: 1862 SCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ---------------RLEIQEAQVSD 1906 Query: 1062 EGVYICEASNTLGQASASADFDAQAVNVQVWPGA-TVRE--GQLVNLTCLVWTTHPAQLT 1118 +G+Y C+ SN G+A + Q P TV + G + LTC V + PA T Sbjct: 1907 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAP-T 1964 Query: 1119 YTWYQDGQQRLDAHSIPLPNVTVR------------DATSYRCGVGPPGRAPRLSRPITL 1166 TW +D R+ S + V R A +Y C R + + Sbjct: 1965 VTWLKD---RMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR--KDFVV 2019 Query: 1167 DVLYAPRNLRLTYLLESH---GGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT 1223 VL APR +R + + H GQ + C D +PP +A G L + Sbjct: 2020 AVLVAPR-IRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY 2078 Query: 1224 L---RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP---EAAVPEGAPI 1277 L L L+G + D G Y+C A +P G+ + RL V V++ P + A G + Sbjct: 2079 LDGGSLVLKGLRASDAGAYTCVAHNPAGE-----DARLHTVNVLVPPTIKQGADGSGTLV 2133 Query: 1278 T-----VTCADPAAHAPTLY-TWYHNG-------RWLQEGPAASLSFLVATRAHAGAYSC 1324 + VT P +P ++ +W +G R L G +L A AG ++C Sbjct: 2134 SRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC 2193 Query: 1325 QAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRA--RSMAVIQCTVDSEPPAELALSHD 1382 A G + R LQV P + D S+ + C P ++ D Sbjct: 2194 VAASPAGV-ADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD 2252 Query: 1383 GKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQ 1441 G+ L + SL G LQ++ V AGD TY C A + G +L Sbjct: 2253 GEPLLS----QSLEQGPS----------LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 2298 Query: 1442 VEGARVVAEPG----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLA 1497 V + + G L + GA + L C G P P W + + L + A Sbjct: 2299 VMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQP----NITWHKDGQALTRLENNSRA 2354 Query: 1498 FTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYP-----PKTPTMMVFVEPEGGLRGIL 1552 + AG+Y CLAE P GA + +RV P P+ P +V + P G L +L Sbjct: 2355 TRVLRVRDAGLYTCLAESPAGAIEKS-FRVRVQAPPNIVGPRGPRFVVGLAP-GQL--VL 2410 Query: 1553 DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612 +C V++EP +T H G + H + ++AL +D G+Y Sbjct: 2411 ECSVEAEPAPKITWH----------RDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYS 2460 Query: 1613 CSASNVLGSASTS 1625 C+A N GS S + Sbjct: 2461 CTARNAAGSTSVA 2473 Score = 201 bits (510), Expect = 7e-51 Identities = 379/1557 (24%), Positives = 563/1557 (36%), Gaps = 298/1557 (19%) Query: 258 VTLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTCQAEN 309 V+L C V++ +P + W KD V L T L L +A SD+G+YTC+A N Sbjct: 1764 VSLPCDVHA-HPN-PEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALN 1821 Query: 310 GVG---SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVL 366 G LV + + + P +L V + +A + +WYK+ Sbjct: 1822 AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQP 1881 Query: 367 LEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPP-LTPVLT 418 L A L + A +D G Y C+V NV G E ++ V PP T Sbjct: 1882 LVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKT 1940 Query: 419 AFLETQAGLVGILHCSVVSEPLATL--------VLSHGGHILASTSGDSDHSPRFSGTSG 470 + AG +L C V P T+ V S H + S G Sbjct: 1941 ETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGG------------- 1987 Query: 471 PNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN---AARLLISPAAE---VVEG 524 RL++ L+ +G Y C A N+ A DF A R+ S A V+EG Sbjct: 1988 ----RLQLSRLQPAQAGTYTCVAENTQAEARK--DFVVAVLVAPRIRSSGVAREHHVLEG 2041 Query: 525 QAVTLSCRSGLSPTPDARFSWYLNGALLHE--GP-------GSSLLLPAASSTDAGSYHC 575 Q V L C + P PD +W +G+ L + GP G SL+L ++DAG+Y C Sbjct: 2042 QEVRLDCEADGQPPPDV--AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2099 Query: 576 RARDGHSASGPSSPA-VLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLL---CRVDSDPP 631 A H+ +G + + VL PP T + D +G R G L+ C V PP Sbjct: 2100 VA---HNPAGEDARLHTVNVLVPP-----TIKQGADGSGTLVSRPGELVTMVCPVRGSPP 2151 Query: 632 ARLQLL------------------HKDRVVATSLPSGGGCSTCGGCSPR--------MKV 665 + L H R+ L + G TC SP ++V Sbjct: 2152 IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQL-ADAGIFTCVAASPAGVADRNFTLQV 2210 Query: 666 TKAPNLLRVEIHNPLLEEEGLYL---CEASN----------------------------- 693 P L VE N ++ G + CEA Sbjct: 2211 QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLE 2270 Query: 694 ALGNASTSATFN-------GQAT----VLAIAPSHTLQEG--TEANLTCNVSRE----AA 736 A+G A S T++ G+A + + P H G TE +LT E A Sbjct: 2271 AVG-AGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 2329 Query: 737 GSPA-NFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP 795 G+P N +W ++G + + + DA LY C + AGA + + V P Sbjct: 2330 GTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGA-IEKSFRVRVQAP 2388 Query: 796 PD-----RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRF 850 P+ P+ L GQ + C+V++ P + +L Q P GRF Sbjct: 2389 PNIVGPRGPRFVVGLAPGQ---LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF 2445 Query: 851 QAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV----SPSPEL 906 L+++ L DSG Y C A N GS TS+ F+V V P+ + Sbjct: 2446 ----------LQLQALSTADSGDYSCTARNAAGS--TSVAFRVEIHTVPTIRSGPPAVNV 2493 Query: 907 QEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST-------SATLRFAAITLTQAGAYH 959 Q +L CQ GVP W +D PL + +LR + AG Y Sbjct: 2494 SVNQTALLPCQAD-GVP-APLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL 2551 Query: 960 CQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDP-PAQLRL 1017 C A + GS + + AP LT T LL C P P + Sbjct: 2552 CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTP----ALLPCEASGSPKPLVVWW 2607 Query: 1018 LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQAS 1077 G +L QG S+ L A P +D + C SN +G+A Sbjct: 2608 KDGQKLDFRLQQGAYRLLPSNALLLTAPGP------------QDSAQFECVVSNEVGEAH 2655 Query: 1078 ASADFDAQAVNVQVWPGATVREGQ----LVNLTCLVWTTHPAQL---TYTWYQDGQQRLD 1130 V V V P T+ + Q + + +V T H + T +W + G Q L Sbjct: 2656 R-----LYQVTVHVPP--TIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ-LG 2707 Query: 1131 AHSIPLPNVTVRDATSYRCGVGPPGRAPRLS-----------RPITLDVLYAPRNLRLTY 1179 A V + + G P A R + + + L V +P L Sbjct: 2708 ARG---SGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPS 2764 Query: 1180 LLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFY 1239 ++ + + L+ C P + G +A+ + V +L + P D G Y Sbjct: 2765 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNY 2824 Query: 1240 SCSARSPLGQA--NTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN 1297 C A++ G A T L +++ V P+ + EG+ + C + P + TW + Sbjct: 2825 LCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNI-TWDKD 2883 Query: 1298 GRWLQ--EG-----PAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAV 1350 G+ + EG P+ L AG Y+C A++A G R+ R L +L P Sbjct: 2884 GQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG-RARRRVHLTILVLPVFTT 2942 Query: 1351 LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR 1410 L R R ++C P + + + + + S V+R Sbjct: 2943 LPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSRE--- 2999 Query: 1411 LQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV---AEPGLDVPEGAALNLSCRL 1467 TYVC A+N +G + + V+ A V+ A L P G ++ L C + Sbjct: 3000 --------DSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV 3051 Query: 1468 LGGPGPVGNSTFAWFWNDRRL------HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAA 1521 G P P W + L H +L R AG Y CLAE G A Sbjct: 3052 RGDPVP----DIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAK 3107 Query: 1522 SAPVMLRVLYPPKTPTMMVF-VEPE-----GGLRGILDCRVDSEPLASLT-LHLGSRLVA 1574 +++ P VF VEP+ G L C+ EP ++ L G L A Sbjct: 3108 KVVILVLQSAP-------VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRA 3160 Query: 1575 SSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631 S + + P + +E + D G Y C A N+LGSA+ + VR Sbjct: 3161 SRRLRTLPDGS------------LWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3205 Score = 179 bits (454), Expect = 2e-44 Identities = 398/1681 (23%), Positives = 604/1681 (35%), Gaps = 297/1681 (17%) Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRV---PTIASPVELLEGTEV 156 L ++ Q D+GSY R S V ++++ L V PR+ P++ PV L T V Sbjct: 750 LRIEQAQLSDAGSY--RCVASNVAGSTELRYGL-RVNVPPRITLPPSLPGPV--LVNTPV 804 Query: 157 DFNCSTPYVCLQEQVRLQW--QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRI 214 C+ L W G + + T Q F G + TL A + D GR Sbjct: 805 RLTCNATGA---PSPTLMWLKDGNPVSPAGTPGLQVFPG---GRVLTLASARA-SDSGRY 857 Query: 215 LRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSI 274 +S Q ++ LQV P IL +++ E V L CQ ++ P V S Sbjct: 858 SCVAVSAVGEDRQ-DVVLQVHMPPS---ILGEELNVSVVANESVALECQSHAMPPPVLS- 912 Query: 275 KWLKDGVRLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA 326 W KDG L+ + GV L + +A DAG YTC+A N G S + Sbjct: 913 -WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGR------SEKHYNL 965 Query: 327 EVQVSPAGPILENQTVTLVCNTPNEAPSDLR------YSWYKNHVLLE---------DAH 371 V V+P P+ E+ T+T+ P + R SW K+ L A Sbjct: 966 NVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAV 1025 Query: 372 SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTP----VLTAFLETQAGL 427 L L A A G Y CE NV G+ S + + V+ PP T Q G Sbjct: 1026 GRLLYLGQAQLAQEGTYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDG- 1083 Query: 428 VGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487 V L C+ +P T+ G + + G + S L + + +G Sbjct: 1084 VATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQS---------LHVERAQAAHTG 1134 Query: 488 EYKCSATNSLGNATSTLDFHANAARLLIS---PAAEVVEG--QAVTLSCRSGLSPTPDAR 542 Y C A N G A + LI P + +TL C + P P R Sbjct: 1135 RYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIR 1194 Query: 543 FSWYLNGALLHEGPGSSLL-------LPAASSTDAGSYHCRARDGHSASGPSSPAVLTVL 595 W+ + G + LL + D+G Y C A + A + VL Sbjct: 1195 --WFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA--SNEAGEARRNFSVEVL 1250 Query: 596 YPPRQPTFTTRLDLDAA-GAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCS 654 PP DL+ G+ L+C V P +L R +A Sbjct: 1251 VPPS----IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR--------- 1297 Query: 655 TCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIA 714 G + + +P+ + +++ L G Y C A+NA+G T + Q +VL +A Sbjct: 1298 ---GDAHHI----SPDGVLLQVLQANLSSAGHYSCIAANAVG----EKTKHFQLSVL-LA 1345 Query: 715 PS--HTLQEGTEANLTCNVSR------EAAGSPA-NFSWFRNGVLWAQGPLETVTLLP-- 763 P+ ++ + +T V+ EA P+ N +W ++G + + LLP Sbjct: 1346 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEAS--RNIQLLPGT 1403 Query: 764 -------VARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFI 816 + DA Y C + E G + + VL PP K L ++G + + Sbjct: 1404 HGLQILNAQKEDAGQYTCVVTNELGEAVKN-YHVEVLIPPSISKDDPLGEVGVKEVKTKV 1462 Query: 817 -------CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869 C + P + + + S QV GR L+++ + Sbjct: 1463 NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL----------LQIQPTQVS 1512 Query: 870 DSGSYRCEATNVLGSSNTSL--------FFQVRG--------------AWVQVSPSPELQ 907 DSG Y C ATNV G + FQ G A V+ E+ Sbjct: 1513 DSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIV 1572 Query: 908 EGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT-------LRFAAITLTQAGAYHC 960 E L C + P + WYR+ QPL + L+ + AG Y C Sbjct: 1573 ENNPAYLYCDTNAIPPPDLT--WYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSC 1630 Query: 961 QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020 +A ++ LH Y +T ++ + + S Q L Sbjct: 1631 KA-------SNEVGEDWLH--YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN 1681 Query: 1021 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080 S LQ G P SPRL V L++ A + D Y+C A N G A Sbjct: 1682 PVPTISWLQN-GLPFSPSPRLQVLEDGQV--LQVSTAEVADAASYMCVAENQAGSAE--- 1735 Query: 1081 DFDAQAVNVQVWP--------GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL--- 1129 + VQV P T V+L C V HP TWY+D Q Sbjct: 1736 --KLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDV-HAHP-NPEVTWYKDSQALSLGE 1791 Query: 1130 ------DAHSIPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVL------YAPRNLR 1176 H++ L + D+ Y C + GR +L + L VL APR + Sbjct: 1792 EVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL---VQLSVLVPPAFRQAPRGPQ 1848 Query: 1177 LTYLLESHGGQLALVLCTVDSRPPAQLALSHAGR-LLASSTAASVPNTLRLELRGPQPRD 1235 L+ G A++ C D+ P + G+ L+ + ++ RLE++ Q D Sbjct: 1849 DAVLVRV--GDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSD 1906 Query: 1236 EGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE---GAPITVTCADPAAHAPTLY 1292 +G YSC + G+A + L ++ P+ G+P+ +TC APT+ Sbjct: 1907 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV- 1965 Query: 1293 TWYHNGRWLQEGP-------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYA 1345 TW + ++ L A AG Y+C A++ Q + + + VL A Sbjct: 1966 TWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQ-AEARKDFVVAVLVA 2024 Query: 1346 PQDAVLSSFRDSRARSMAVIQ--CTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403 P+ R+ ++ C D +PP ++A DG L G H G Sbjct: 2025 PRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSL 2084 Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV-------EGA----RVVAEPG 1452 V + L+ D A Y C A N G + + + V +GA +V+ P Sbjct: 2085 VLKG---LRASDAGA----YTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRP- 2136 Query: 1453 LDVPEGAALNLSCRLLGGPGPVGNSTFAWF-------WNDRRLHAEPVPTLAFTHVARAQ 1505 G + + C + G P P+ S W + R L TL + V A Sbjct: 2137 -----GELVTMVCPVRGSP-PIHVS---WLKDGLPLPLSQRTLLHGSGHTLRISKVQLAD 2187 Query: 1506 AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI---LDCRVDSEPLA 1562 AG++ C+A P G A L+V PP + F +RG L C PL Sbjct: 2188 AGIFTCVAASPAG-VADRNFTLQVQVPPVLEP-VEFQNDVVVVRGSLVELPCEARGVPLP 2245 Query: 1563 SLT-LHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621 ++ + G L++ S QG + +EA+ D G Y C A + G Sbjct: 2246 LVSWMKDGEPLLSQSLEQGP---------------SLQLEAVGAGDSGTYSCVAVSEAGE 2290 Query: 1622 A 1622 A Sbjct: 2291 A 2291 Score = 176 bits (445), Expect = 2e-43 Identities = 378/1579 (23%), Positives = 578/1579 (36%), Gaps = 296/1579 (18%) Query: 200 ETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVT 259 ++LH+ + H C RA+ + L V P+ + L + +T Sbjct: 1121 QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLT 1180 Query: 260 LTCQVNSSYPAVSSIKWLK--------DGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGV 311 L C+ P +I+W + + L +L + Q D+G+Y+C A N Sbjct: 1181 LLCEAMGIPPP--AIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEA 1238 Query: 312 GSLVSPPISLHIFMAEVQVSPAGP---------ILENQTVTLVCNTPNEAPSDLRYSWYK 362 G + F EV V P+ +L+ QT L+CN L +W+K Sbjct: 1239 GE------ARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFK 1290 Query: 363 NHVLLEDAHSH-------TLRLHLATRADTGFYFCEVQNVHGSE-RSGPVSVVVNHPPLT 414 + L +H L++ A + G Y C N G + + +SV+ L Sbjct: 1291 DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL-----LA 1345 Query: 415 PVLTAFLETQAG---LVGI-----LHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466 P + E A V + L C ++ P + G + S + Sbjct: 1346 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEA----SRNIQLLP 1401 Query: 467 GTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA-------- 518 GT G L+I + ++ D+G+Y C TN LG A ++H +LI P+ Sbjct: 1402 GTHG-----LQILNAQKEDAGQYTCVVTNELGEAVK--NYH---VEVLIPPSISKDDPLG 1451 Query: 519 ------AEVVEGQAVTLSCRSGLSPTPDARFSWYLNG-------ALLHEGPGSSLLLPAA 565 + +TL C S P P R WY +G L G G L + Sbjct: 1452 EVGVKEVKTKVNSTLTLECESWAVPPPTIR--WYKDGQPVTPSSRLQVLGEGRLLQIQPT 1509 Query: 566 SSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP---RQPTFTTRLDL-----DAAGAGAG 617 +D+G Y C A + ++ V PP + F+ ++ +A G Sbjct: 1510 QVSDSGRYLCVATNVAGEDDQDFNVLIQV--PPMFQKVGDFSAAFEILSREEEARGGVTE 1567 Query: 618 RRGL-------LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPN 670 R + L C ++ PP L +D+ L +G S G +V + P Sbjct: 1568 YREIVENNPAYLYCDTNAIPPPDLTWYREDQ----PLSAGDEVSVLQG----GRVLQIP- 1618 Query: 671 LLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCN 730 L+R E G Y C+ASN +G + + + L E N + Sbjct: 1619 LVRA-------ENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASST 1671 Query: 731 VSRE--AAGSPA-NFSWFRNGVLWAQGP----LETVTLLPVAR---TDAALYACRILTEA 780 VS + A G+P SW +NG+ ++ P LE +L V+ DAA Y C +A Sbjct: 1672 VSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQA 1731 Query: 781 GAQLSTPVLLSVLYPP-----DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHL 835 G+ L V PP D +++A+L+ C V + P + + Sbjct: 1732 GS-AEKLFTLRVQVPPRIAGLDLEQVTAILNSS----VSLPCDVHAHPNPEVTWYKDSQ- 1785 Query: 836 LATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN--TSLFFQV 893 A SLG +V + L++ L DSG Y CEA N G L V Sbjct: 1786 -ALSLGEEV--------FLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV 1836 Query: 894 RGAWVQVSPSPE----LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP--LQESTSA---- 943 A+ Q P+ ++ G VLSC+ +PE T WY+DGQP L + T A Sbjct: 1837 PPAFRQAPRGPQDAVLVRVGDKAVLSCET-DALPEPT-VTWYKDGQPLVLAQRTQALRGG 1894 Query: 944 -TLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYA-PRHVTLTTLMDTGPGRL 1000 L ++ G Y C+ + G A + + + ++ P+ T++ + G Sbjct: 1895 QRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQV----AGSP 1950 Query: 1001 GLLLCRVDSDPPAQLRLLHGDRL--VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAM 1058 +L C V P + L DR+ +S + GV G RL++ Sbjct: 1951 LVLTCDVSGVPAPTVTWLK-DRMPVESSAVHGVVSRGG--------------RLQLSRLQ 1995 Query: 1059 LEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGAT---------VREGQLVNLTCLV 1109 G Y C A NT QA A DF V V V P V EGQ V L C Sbjct: 1996 PAQAGTYTCVAENT--QAEARKDF---VVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEA 2050 Query: 1110 WTTHPAQLTYTWYQDGQQ-----------RLDAHSIPLPNVTVRDATSYRC-GVGPPGRA 1157 P + W +DG LD S+ L + DA +Y C P G Sbjct: 2051 DGQPPPDV--AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 2108 Query: 1158 PRLSRPITLDVLYAP---RNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLAS 1214 RL T++VL P + + L S G+L ++C V PP ++ G L Sbjct: 2109 ARLH---TVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL 2165 Query: 1215 STAASVPNT-LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP-----E 1268 S + + L + Q D G ++C A SP G A+ + L+++ V +L P + Sbjct: 2166 SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ-VPPVLEPVEFQND 2224 Query: 1269 AAVPEGAPITVTCADPAAHAPTLYTWYHNG-----RWLQEGPAASLSFLVATRAHAGAYS 1323 V G+ + + C P L +W +G + L++GP+ L + A +G YS Sbjct: 2225 VVVVRGSLVELPCEARGVPLP-LVSWMKDGEPLLSQSLEQGPSLQLEAVGA--GDSGTYS 2281 Query: 1324 CQAQDAQGTRSSRPAALQVLYAP--QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSH 1381 C A G + R L V+ P +D+ + + + C P + Sbjct: 2282 CVAVSEAG-EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK 2340 Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQ 1441 DG+ L T +R L+V+D Y C A++ G+I R+ Sbjct: 2341 DGQAL------------TRLENNSRATRVLRVRDA----GLYTCLAESPAGAIEKSFRV- 2383 Query: 1442 VEGARVVAEPGLDVPEG---------AALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP 1492 RV A P + P G L L C + P P W D + E Sbjct: 2384 ----RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAP----KITWH-RDGIVLQED 2434 Query: 1493 VPT--------LAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLY--PPKTPTMMVFV 1542 T L ++ A +G Y C A AA S V RV P + V Sbjct: 2435 AHTQFPERGRFLQLQALSTADSGDYSCTAR---NAAGSTSVAFRVEIHTVPTIRSGPPAV 2491 Query: 1543 EPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEA 1602 +L C+ D P A L R+ P P +L +LR I+ Sbjct: 2492 NVSVNQTALLPCQADGVP-APLVSWRKDRVPLD------PRSPRFEILPE-GSLR--IQP 2541 Query: 1603 LRPSDQGEYICSASNVLGS 1621 + D G Y+C ASN GS Sbjct: 2542 VLAQDAGHYLCLASNSAGS 2560 Score = 175 bits (444), Expect = 3e-43 Identities = 366/1579 (23%), Positives = 562/1579 (35%), Gaps = 275/1579 (17%) Query: 201 TLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQV--KYAPKGVKILL-----SPSGRNIL 253 TLH+ DH + CQ + A +E+ + V ++AP +++ + + Sbjct: 553 TLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSF 612 Query: 254 PGELVTLTCQVNSSYPAVSSIK-WLKDGVRLQTKTGV---------LHLPQAAWSDAGVY 303 P + ++P ++ W G TG+ L + + D G+Y Sbjct: 613 PAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIY 672 Query: 304 TCQAENGVGSLVSPPISLHIFMAEVQVSPAG-PILENQTVTLVCNTPNEAPSDLRYSWYK 362 TC A N G + ++ P +LEN +VTL C P D+ SW+K Sbjct: 673 TCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDV--SWFK 730 Query: 363 NHV-------LLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPP--- 412 H + LR+ A +D G Y C NV GS + VN PP Sbjct: 731 GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL-RYGLRVNVPPRIT 789 Query: 413 LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSG-- 470 L P L + + L C+ P TL+ G+ ++ +GT G Sbjct: 790 LPPSLPGPVLVNTPV--RLTCNATGAPSPTLMWLKDGNPVSP-----------AGTPGLQ 836 Query: 471 --PNSLRLEIRDLEETDSGEYKCSATNSLGNATS--TLDFHANAARLLISPAAEVVEGQA 526 P L + +DSG Y C A +++G L H + L VV ++ Sbjct: 837 VFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANES 896 Query: 527 VTLSCRSGLSPTPDARFSWYLNGALLHEGPG-------SSLLLPAASSTDAGSYHCRA-- 577 V L C+S P P SW+ +G L PG + L + A DAG Y C A Sbjct: 897 VALECQSHAMPPP--VLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALN 954 Query: 578 RDGHSASGPSSPAVLTVLYPPRQP-TFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQL 636 + G S + + ++P R+ T T R G L C P ++ Sbjct: 955 QAGRSEKHYNLNVWVAPVFPLRESHTLTVR---------EGHPTSLSCECRGVPFPKISW 1005 Query: 637 LHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG 696 R LP G + V+ LL + L +EG Y CE SN +G Sbjct: 1006 ----RKDGQPLPGEG--------AGLQHVSAVGRLL--YLGQAQLAQEGTYTCECSNVVG 1051 Query: 697 NASTSATFNGQATVLAIAPSH------TLQEGTEANLTCNVSREAAGSPANFSWFRNGV- 749 N+S P +Q+G A L CN + + P +W R+G Sbjct: 1052 NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGV-ATLECNATGK---PPPTVTWERDGQP 1107 Query: 750 ------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDR-PKLS 802 L Q +++ + Y+C + + LSVL PP+ L Sbjct: 1108 VGAELGLQLQNQGQSLHVERAQAAHTGRYSC-VAENLAGRAERKFELSVLVPPELIGDLD 1166 Query: 803 ALLDMGQG-HMAL-FICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLK 860 L ++ H L +C P + F GE P P + A Sbjct: 1167 PLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEE-------PVSPGEDTYLL---AGGWM 1216 Query: 861 LEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPE---------LQEGQA 911 L++ + DSG Y C A+N G + + + V V PS E + +GQ Sbjct: 1217 LKMTQTQEQDSGLYSCLASNEAGEARRNFSVE-----VLVPPSIENEDLEEVIKVLDGQT 1271 Query: 912 VVLSCQVHTGVPEGTSYRWYRDGQPLQESTS-------ATLRFAAITLTQAGAYHC-QAQ 963 L C V TG P+ W++DG+PL + L+ L+ AG Y C A Sbjct: 1272 AHLMCNV-TGHPQ-PKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 1329 Query: 964 APGSAT-----TSLAAPISL--HVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLR 1016 A G T + L AP L A VT+T L+C + P + Sbjct: 1330 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPIS------LICEALAFPSPNI- 1382 Query: 1017 LLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQA 1076 T G P +S ++ + P T L+I A ED G Y C +N LG+A Sbjct: 1383 ----------TWMKDGAPFEAS--RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEA 1430 Query: 1077 ------------SASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQD 1124 S S D V V+ + + L C W P T WY+D Sbjct: 1431 VKNYHVEVLIPPSISKDDPLGEVGVK---EVKTKVNSTLTLECESWAVPPP--TIRWYKD 1485 Query: 1125 GQ-----QRL----DAHSIPLPNVTVRDATSYRC-GVGPPG----------RAPRLSRPI 1164 GQ RL + + + V D+ Y C G + P + + + Sbjct: 1486 GQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKV 1545 Query: 1165 -----TLDVLYAPRNLR--LTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTA 1217 ++L R +T E A + C ++ PP L + L++ Sbjct: 1546 GDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDE 1605 Query: 1218 ASVPNTLR-LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVI------LAPEAA 1270 SV R L++ + + G YSC A + +G+ EL + VI L E Sbjct: 1606 VSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVT 1665 Query: 1271 VPEGAPITVTCADPAAHAPTLYTWYHNG---------RWLQEGPAASLSFLVATRAHAGA 1321 V + +++ C PT+ +W NG + L++G +S A A A + Sbjct: 1666 VNASSTVSLQCPALGNPVPTI-SWLQNGLPFSPSPRLQVLEDGQVLQVS--TAEVADAAS 1722 Query: 1322 YSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV-IQCTVDSEPPAELALS 1380 Y C A++ G+ + + L+V P+ A L + + + +V + C V + P E+ Sbjct: 1723 YMCVAENQAGS-AEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWY 1781 Query: 1381 HDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRL 1440 D + L+ V L GT +Q+ R L + Y C A N G + +L Sbjct: 1782 KDSQALSLGEEVF-LLPGTHTLQLGRARL--------SDSGMYTCEALNAAGRDQKLVQL 1832 Query: 1441 QV------EGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRL----HA 1490 V A + + V G LSC P P T W+ + + L Sbjct: 1833 SVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEP----TVTWYKDGQPLVLAQRT 1888 Query: 1491 EPVPTLAFTHVARAQA---GMYHCLAELPTGAAASAPVMLRVLYP----PKTPTMMVFVE 1543 + + + AQ G+Y C G A + + P PKT T V Sbjct: 1889 QALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTET----VS 1944 Query: 1544 PEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEAL 1603 G +L C V P ++T V SS +H + S R+ + L Sbjct: 1945 QVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSA---------VHGVVSRGG-RLQLSRL 1994 Query: 1604 RPSDQGEYICSASNVLGSA 1622 +P+ G Y C A N A Sbjct: 1995 QPAQAGTYTCVAENTQAEA 2013 Score = 156 bits (395), Expect = 1e-37 Identities = 304/1275 (23%), Positives = 456/1275 (35%), Gaps = 220/1275 (17%) Query: 476 LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE-----------G 524 L + + DSG+Y+C ATN +G+ + A+L++ + E G Sbjct: 59 LFLASVSPADSGDYECQATNEVGST-------SRRAKLVVYVPPSIREDGRKANVSGMAG 111 Query: 525 QAVTLSCRSGLSPTPD----------------ARFSWYLNGA------LLHEGPGSSLLL 562 Q++TL C + P P+ A + W L LL E G SL Sbjct: 112 QSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDE--GQSLHF 169 Query: 563 PAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLL 622 P +G +A P + P F+ GAGA + L Sbjct: 170 PRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLG 229 Query: 623 LCRVD-------SDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVE 675 L D S P KDR LP G P ++V + +LR Sbjct: 230 LAGADVELQCWTSGVPTPQVEWTKDR--QPVLPGG----------PHLQVQEDGQVLR-- 275 Query: 676 IHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREA 735 I + +EG Y C A + G + A + T + + + EA Sbjct: 276 ITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEA 335 Query: 736 AGSPA-NFSWFRNG--------VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLST 786 G P N +WF++G V++ +G + + L +DA +Y C+ GA Sbjct: 336 RGVPTPNITWFKDGALLPTSTKVVYTRGGRQ-LQLGRAQSSDAGVYTCKASNAVGA-AEK 393 Query: 787 PVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPS 846 L V PP G G + V RP+AL + G P + Sbjct: 394 ATRLDVYVPPTIE--------GAGGRPYVVKAVAGRPVALECVARGHP------SPTLSW 439 Query: 847 HGRFQAKAEANSLKLE-------VRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQ 899 H AE+N +LE + G SG Y C A++ G + L + V VQ Sbjct: 440 HHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA--VLQYSVE---VQ 494 Query: 900 VSPSPELQE---------GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQE-------STSA 943 V P + E GQ + L CQ +G P T +W ++G+P +E S Sbjct: 495 VPPQLLVAEGLGQVTTIVGQPLELPCQA-SGSPVPT-IQWLQNGRPAEELAGVQVASQGT 552 Query: 944 TLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLL 1003 TL + L +G + CQA + T +S+H +AP V + G Sbjct: 553 TLHIDHVELDHSGLFACQA-TNEAGTAGAEVEVSVHGEWAP-GVLEVPIGQYHWGXEHHS 610 Query: 1004 LCRVDSDPPAQLRL-LHGDRLVASTLQGVGGPEGSSPRLHVAVA-PNTLRLEIHGAMLED 1061 DPP H + G G + VA + P L++E L D Sbjct: 611 SFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIE--KVDLRD 668 Query: 1062 EGVYICEASNTLGQASASADFDAQA-VNVQVWP-GATVREGQLVNLTCLVWTTHPAQLTY 1119 EG+Y C A+N G++ N++ P V E V L CL P + Sbjct: 669 EGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDV-- 726 Query: 1120 TWYQDGQQ---------RLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV-- 1168 +W++ Q +D + + + DA SYRC + L + ++V Sbjct: 727 SWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPP 786 Query: 1169 -LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASV---PNTL 1224 + P +L L+ + + C P L G ++ + + P Sbjct: 787 RITLPPSLPGPVLVNTP----VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGR 842 Query: 1225 RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPE--AAVPEGAPITVTCA 1282 L L + D G YSC A S +G+ + L++ IL E +V + + C Sbjct: 843 VLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQ 902 Query: 1283 DPAAHAPTLYTWYHNGRWLQEGPAASLS----FLVATRA---HAGAYSCQAQDAQGTRSS 1335 A P L +W+ +GR L+ P LS L RA AG Y+C+A + G RS Sbjct: 903 SHAMPPPVL-SWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAG-RSE 960 Query: 1336 RPAALQVLYAP----QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSG 1391 + L V AP +++ + R+ S++ C P +++ DG+ L Sbjct: 961 KHYNLNVWVAPVFPLRESHTLTVREGHPTSLS---CECRGVPFPKISWRKDGQPLPGE-- 1015 Query: 1392 VHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEP 1451 +G HV L L Q A + TY C N++G+ S +L+V +A P Sbjct: 1016 ----GAGLQHVSAVGRLLYLG-QAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGP 1070 Query: 1452 -----GLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTL----AFTHVA 1502 + V + L C G P P T W + + + AE L HV Sbjct: 1071 REPPTQVSVVQDGVATLECNATGKPPP----TVTWERDGQPVGAELGLQLQNQGQSLHVE 1126 Query: 1503 RAQA---GMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSE 1559 RAQA G Y C+AE G A L VL PP+ L G LD Sbjct: 1127 RAQAAHTGRYSCVAENLAG-RAERKFELSVLVPPE-------------LIGDLD------ 1166 Query: 1560 PLASLTLHLGSRLVASSQPQG------------APAEPHIHVLASPNALRVDIEALRPSD 1607 PL ++T L S L + G P P + + + D Sbjct: 1167 PLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQD 1226 Query: 1608 QGEYICSASNVLGSA 1622 G Y C ASN G A Sbjct: 1227 SGLYSCLASNEAGEA 1241 Score = 152 bits (385), Expect = 2e-36 Identities = 358/1572 (22%), Positives = 539/1572 (34%), Gaps = 279/1572 (17%) Query: 210 DHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYP 269 D GR S A +A+ + L+V +AP + ++ LV L C+ Sbjct: 283 DEGRYQCVAFSPAGQQAR-DFQLRV-HAPPTIWGSNETGEVAVMEDHLVQLLCEARGV-- 338 Query: 270 AVSSIKWLKDGVRLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISL 321 +I W KDG L T T V L L +A SDAGVYTC+A N VG+ L Sbjct: 339 PTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA-AEKATRL 397 Query: 322 HIFMAEVQVSPAG-----PILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH----- 371 +++ G + + V L C L SW+ + + +++ Sbjct: 398 DVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL--SWHHEGLPVAESNESRLE 455 Query: 372 --SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF--LETQAGL 427 LRL A +G Y C + G E SV V PP V + T G Sbjct: 456 TDGSVLRLESPGEASSGLYSCVASSPAG-EAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQ 514 Query: 428 VGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487 L C P+ T+ G +G S GT+ L I +E SG Sbjct: 515 PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVAS---QGTT------LHIDHVELDHSG 565 Query: 488 EYKCSATNSLGNATSTLDFHAN---AARLLISPAAEVVEG----QAVTLSCRS------G 534 + C ATN G A + ++ + A +L P + G + +C G Sbjct: 566 LFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWG 625 Query: 535 LSPTPDARFSWYLNGALLHEGPG--------SSLLLPAASSTDAGSYHCRARDGHSASGP 586 P P W G+L E G L + D G Y C A + A Sbjct: 626 AHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT--NLAGES 683 Query: 587 SSPAVLTVLYPPR-QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVAT 645 L VL PP +P + L+ A L C PP + + V Sbjct: 684 KREVALKVLVPPNIEPGPVNKAVLENASV------TLECLASGVPPPDVSWFKGHQPV-- 735 Query: 646 SLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFN 705 S M VT + + + I L + G Y C ASN G ST + Sbjct: 736 --------------SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG--STELRYG 779 Query: 706 GQATV---LAIAPS--HTLQEGTEANLTCNVSREAAGSPA-NFSWFRNG--VLWAQGP-- 755 + V + + PS + T LTCN A G+P+ W ++G V A P Sbjct: 780 LRVNVPPRITLPPSLPGPVLVNTPVRLTCN----ATGAPSPTLMWLKDGNPVSPAGTPGL 835 Query: 756 -----LETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQG 810 +TL +D+ Y+C ++ G V+L V PP + + Sbjct: 836 QVFPGGRVLTLASARASDSGRYSCVAVSAVGED-RQDVVLQVHMPPSILGEELNVSVVAN 894 Query: 811 HMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGD 870 C + P +L+ + P R A+ L+V + D Sbjct: 895 ESVALECQSHAMPPPVLSWWKDGR----------PLEPRPGVHLSADKALLQVDRADVWD 944 Query: 871 SGSYRCEATNVLGSSNTSLFFQVRGAWV------QVSPSPELQEGQAVVLSCQVHTGVPE 924 +G Y CEA N G S V WV + S + ++EG LSC+ GVP Sbjct: 945 AGHYTCEALNQAGRSEKHYNLNV---WVAPVFPLRESHTLTVREGHPTSLSCECR-GVP- 999 Query: 925 GTSYRWYRDGQPLQESTSATLRFAAI---------TLTQAGAYHCQ-AQAPGSATTSLAA 974 W +DGQPL + +A+ L Q G Y C+ + G+++ L Sbjct: 1000 FPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQL 1059 Query: 975 PISLHVSYA-PRH-VTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVG 1032 + + A PR T +++ G + L C PP + T + G Sbjct: 1060 EVHVPPQIAGPREPPTQVSVVQDG---VATLECNATGKPPPTV-----------TWERDG 1105 Query: 1033 GPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVW 1092 P G+ L + +L +E A G Y C A N G+A + ++V V Sbjct: 1106 QPVGAELGLQLQNQGQSLHVE--RAQAAHTGRYSCVAENLAGRAERKFE-----LSVLVP 1158 Query: 1093 PGATVREGQLVNLTCLVWTTHPAQL----------TYTWY---------QDGQQRLDAHS 1133 P L N+T + + P L W+ +D Sbjct: 1159 PELIGDLDPLTNITAALHS--PLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM 1216 Query: 1134 IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAP--RNLRLTYLLESHGGQLALV 1191 + + +D+ Y C A R +++VL P N L +++ GQ A + Sbjct: 1217 LKMTQTQEQDSGLYSCLAS--NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHL 1274 Query: 1192 LCTVDSRPPAQLALSHAGRLLASSTAASV-PNTLRLELRGPQPRDEGFYSCSARSPLGQA 1250 +C V P +L GR LA A + P+ + L++ G YSC A + +G+ Sbjct: 1275 MCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEK 1334 Query: 1251 NTSLELRLEGVRVILAP------------EAAVPEGAPITVTCADPAAHAPTLYTWYHNG 1298 +L V+LAP E V PI++ C A +P + TW +G Sbjct: 1335 TKHFQL-----SVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNI-TWMKDG 1388 Query: 1299 ------RWLQEGPAA-SLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP---QD 1348 R +Q P L L A + AG Y+C + G + + ++VL P +D Sbjct: 1389 APFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG-EAVKNYHVEVLIPPSISKD 1447 Query: 1349 AVLSSFR----DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQV 1404 L ++ S ++C + PP + DG+ + SS + L G Sbjct: 1448 DPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR----- 1502 Query: 1405 ARNALRLQVQDVPAGDD-TYVCTAQNLLGS--------------ISTIGRLQV------- 1442 LQ+Q D Y+C A N+ G +G Sbjct: 1503 -----LLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSR 1557 Query: 1443 -EGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA-------EPVP 1494 E AR ++ E L C P P W+ D+ L A + Sbjct: 1558 EEEARGGVTEYREIVENNPAYLYCDTNAIPPP----DLTWYREDQPLSAGDEVSVLQGGR 1613 Query: 1495 TLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPP----KTPTMMVFVEPEGGLRG 1550 L V AG Y C A G +L VL PP T ++ V Sbjct: 1614 VLQIPLVRAENAGRYSCKASNEVGEDWLHYELL-VLTPPVILGDTEELVEEVTVNASSTV 1672 Query: 1551 ILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGE 1610 L C P+ ++ S G P P + + + + +D Sbjct: 1673 SLQCPALGNPVPTI----------SWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAAS 1722 Query: 1611 YICSASNVLGSA 1622 Y+C A N GSA Sbjct: 1723 YMCVAENQAGSA 1734 Score = 148 bits (374), Expect = 4e-35 Identities = 309/1299 (23%), Positives = 445/1299 (34%), Gaps = 234/1299 (18%) Query: 251 NILPGELVTLTCQVNSSYPAVSSIKWLKDG----------VRLQTKTGVLHLPQAAWSDA 300 ++L G+ V L C+ + P + WLKDG +R G L L SDA Sbjct: 2037 HVLEGQEVRLDCEADGQPPP--DVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA 2094 Query: 301 GVYTCQAENGVGS---------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNE 351 G YTC A N G LV P I + VS G + VT+VC Sbjct: 2095 GAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGEL-----VTMVCPVRGS 2149 Query: 352 APSDLRYSWYKNHVLLE-------DAHSHTLRLHLATRADTGFYFCEVQNVHG-SERSGP 403 P + SW K+ + L HTLR+ AD G + C + G ++R+ Sbjct: 2150 PP--IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFT 2207 Query: 404 VSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP 463 + V V P L PV E Q +V VV L L G L S D P Sbjct: 2208 LQVQVP-PVLEPV-----EFQNDVV------VVRGSLVELPCEARGVPLPLVSWMKDGEP 2255 Query: 464 RFSGT--SGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEV 521 S + GP+ L++ + DSG Y C A + G A ++ P Sbjct: 2256 LLSQSLEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQL------TVMEPPHIE 2306 Query: 522 VEGQAVTLSCRSGL--------SPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSY 573 GQ LS G TP +W+ +G L +S DAG Y Sbjct: 2307 DSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLY 2366 Query: 574 HCRARDGHSASGPSSPAVLTV---LYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDP 630 C A A S + + PR P F L A + +L C V+++P Sbjct: 2367 TCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGL--------APGQLVLECSVEAEP 2418 Query: 631 PARLQLLHKDRVVA-----TSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685 ++ H+D +V T P G +++ + G Sbjct: 2419 APKITW-HRDGIVLQEDAHTQFPERGRF--------------------LQLQALSTADSG 2457 Query: 686 LYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANF-SW 744 Y C A NA G STS F + + S N T + +A G PA SW Sbjct: 2458 DYSCTARNAAG--STSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSW 2515 Query: 745 FRNGV-------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPD 797 ++ V + P ++ + PV DA Y C AG+ L VL PP Sbjct: 2516 RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDL-RVLEPPA 2574 Query: 798 RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEAN 857 + L + AL C P L+ + L L G ++ +N Sbjct: 2575 IAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL-----QQGAYRL-LPSN 2628 Query: 858 SLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQA------ 911 +L L G DS + C +N +G ++ R V V P + + Q Sbjct: 2629 ALLLTAP--GPQDSAQFECVVSNEVGEAH-------RLYQVTVHVPPTIADDQTDFTVTM 2679 Query: 912 ---VVLSCQVHTGVPEGTSYRWYRDGQPL-------QESTSATLRFAAITLTQAGAYHCQ 961 VVL+C TG+P T W + G L + S S L AG Y C Sbjct: 2680 MAPVVLTCH-STGIPAPT-VSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCS 2737 Query: 962 AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGD 1021 A+ + L V +P L +++ LL C P + Sbjct: 2738 ARNSAGVAHK---HVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG 2794 Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081 VA+ + P G +L I A ED G Y+C A N+ G A Sbjct: 2795 LNVATGVSTQVLPGG--------------QLRIAHASPEDAGNYLCIAKNSAGSAMGKTR 2840 Query: 1082 FDAQAVNV--QVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS------ 1133 Q V P + EG L C + +T W +DGQ A Sbjct: 2841 LVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNIT--WDKDGQPVSGAEGKFTIQP 2898 Query: 1134 ---IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAP--------RNLRLTYLL- 1181 + + N+ +DA +Y C R R + L +L P R+LRL L Sbjct: 2899 SGELLVKNLEGQDAGTYTCTA--ENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLW 2956 Query: 1182 ---ESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGF 1238 + G + TV+ RP + G A S D G Sbjct: 2957 LRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVS-------------REDSGT 3003 Query: 1239 YSCSARSPLGQANTSLELRLEGVRVILAPEAAV---PEGAPITVTCADPAAHAPTLYTWY 1295 Y C A + +G+ + ++ V+ + P G I + C P ++ W Sbjct: 3004 YVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIH-WI 3062 Query: 1296 HNG---------RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP 1346 +G LQ G SL+ R AG Y C A++ G + + L + AP Sbjct: 3063 KDGLPLRGSHLRHQLQNG---SLTIHRTERDDAGRYQCLAENEMGV-AKKVVILVLQSAP 3118 Query: 1347 QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVAR 1406 V R+ ++C EP + G+ L S + +L G+ Sbjct: 3119 VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGS------- 3171 Query: 1407 NALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQVEG 1444 L +++V GD TY C A NLLGS + L V G Sbjct: 3172 ----LWLENVETGDAGTYDCVAHNLLGSATARAFLVVRG 3206 Score = 144 bits (362), Expect = 1e-33 Identities = 356/1523 (23%), Positives = 529/1523 (34%), Gaps = 293/1523 (19%) Query: 250 RNILPGELVTLTCQVNSSYPAVSSIKWLK--------DGVRLQTKTGVLHLPQAAWSDAG 301 R I+ L C N+ P + W + D V + VL +P +AG Sbjct: 1569 REIVENNPAYLYCDTNAIPPP--DLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAG 1626 Query: 302 VYTCQAENGVGS--------LVSPPISL---HIFMAEVQVSPAGPILENQTVTLVCNT-P 349 Y+C+A N VG +++PP+ L + EV V+ + TV+L C Sbjct: 1627 RYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS------TVSLQCPALG 1680 Query: 350 NEAPSDLRYSWYKNHV---------LLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSER 400 N P+ SW +N + +LED L++ A AD Y C +N GS Sbjct: 1681 NPVPT---ISWLQNGLPFSPSPRLQVLEDGQ--VLQVSTAEVADAASYMCVAENQAGSAE 1735 Query: 401 SGPVSVVVNHPPLTPVL-----TAFLETQAGLVGILHCSVVSEPL---ATLVLSHGGHIL 452 ++ V PP L TA L + L +H E + LS G + Sbjct: 1736 K-LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVF 1794 Query: 453 ASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR 512 P + L++ +DSG Y C A N+ G + Sbjct: 1795 LL----------------PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLS----- 1833 Query: 513 LLISPAAE-----------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP----- 556 +L+ PA V G LSC + P P +WY +G L Sbjct: 1834 VLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTV--TWYKDGQPLVLAQRTQAL 1891 Query: 557 --GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGA 614 G L + A +D G Y C+ + A LTV PP T AG+ Sbjct: 1892 RGGQRLEIQEAQVSDKGLYSCKV--SNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGS 1949 Query: 615 GAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRV 674 +L C V P + L KDR+ S G S G R+ Sbjct: 1950 PL----VLTCDVSGVPAPTVTWL-KDRMPVESSAVHGVVSRGG---------------RL 1989 Query: 675 EIHNPLLEEEGLYLCEASNALGNAS----TSATFNGQATVLAIAPSHTLQEGTEANLTCN 730 ++ + G Y C A N A + + +A H + EG E L C Sbjct: 1990 QLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC- 2048 Query: 731 VSREAAGSPA-NFSWFRNGVLWAQ--GPL-------ETVTLLPVARTDAALYACRILTEA 780 EA G P + +W ++G Q GP ++ L + +DA Y C A Sbjct: 2049 ---EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPA 2105 Query: 781 G--AQLSTPVLLSVLYPPDRPKL---SALLDMGQGHMALFICTV-DSRPLALLALFHGEH 834 G A+L T ++VL PP + S L G + +C V S P+ + L G Sbjct: 2106 GEDARLHT---VNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDG-- 2160 Query: 835 LLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894 L L + HG + L + ++ L D+G + C A + G ++ + QV Sbjct: 2161 -LPLPLSQRTLLHG--------SGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV- 2210 Query: 895 GAWVQVSPSPELQE---------GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST---S 942 QV P E E G V L C+ GVP W +DG+PL + Sbjct: 2211 ----QVPPVLEPVEFQNDVVVVRGSLVELPCEAR-GVPLPL-VSWMKDGEPLLSQSLEQG 2264 Query: 943 ATLRFAAITLTQAGAYHCQA-----QAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP 997 +L+ A+ +G Y C A +A ++ P + S P ++LT P Sbjct: 2265 PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLT------P 2318 Query: 998 GRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGA 1057 G LLC P + H D + L+ + + A LR+ Sbjct: 2319 GAPMELLCDAQGTPQPNITW-HKDGQALTRLE------------NNSRATRVLRVR---- 2361 Query: 1058 MLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGAT-----VREGQLVNLTCLVWTT 1112 D G+Y C A + G S QA V P + GQLV L C V Sbjct: 2362 ---DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSV-EA 2416 Query: 1113 HPAQLTYTWYQDG-QQRLDAHS--------IPLPNVTVRDATSYRC----GVGPPGRAPR 1159 PA TW++DG + DAH+ + L ++ D+ Y C G A R Sbjct: 2417 EPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2475 Query: 1160 LSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGR--LLASSTA 1217 + + P + ++ Q AL+ C D PA L R L S Sbjct: 2476 VEIHTVPTIRSGPPAVNVSV------NQTALLPCQADG-VPAPLVSWRKDRVPLDPRSPR 2528 Query: 1218 ASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPI 1277 + L ++ +D G Y C A + G +LR +L P A P + + Sbjct: 2529 FEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR------VLEPPAIAPSPSNL 2582 Query: 1278 TVTCADPA-------AHAPTLYTWYHNGRWL----QEG-----PAASLSFLVATRAHAGA 1321 T+T PA L W+ +G+ L Q+G P+ +L + Sbjct: 2583 TLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQ 2642 Query: 1322 YSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMA--VIQCTVDSEPPAELAL 1379 + C + G QV + D MA V+ C P ++ Sbjct: 2643 FECVVSNEVGEAHR---LYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSW 2699 Query: 1380 SHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGR 1439 S G L A G+G+ AL + Q +P Y C+A+N G Sbjct: 2700 SKAGAQLG--------ARGSGYRVSPSGALEIG-QALPIHAGRYTCSARNSAGVAHKHVF 2750 Query: 1440 LQVEGARVVAEPGLDVPEGAA---LNLSCRLLGGPGPVGNSTFAWFWNDRRL------HA 1490 L V+ + VV +P V A + L C G P P T W + Sbjct: 2751 LTVQASPVV-KPLPSVVRAVAEEEVLLPCEASGIPRP----TITWQKEGLNVATGVSTQV 2805 Query: 1491 EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRG 1550 P L H + AG Y C+A+ G+A L V PP + + G Sbjct: 2806 LPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGK-TRLVVQVPPVIENGLPDLSTTEGSHA 2864 Query: 1551 ILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGE 1610 L C+ P ++T + V+ AE + S L ++ L D G Sbjct: 2865 FLPCKARGSPEPNITWDKDGQPVSG-------AEGKFTIQPSGELL---VKNLEGQDAGT 2914 Query: 1611 YICSASNVLGSASTSTYFGVRAL 1633 Y C+A N +G A + + L Sbjct: 2915 YTCTAENAVGRARRRVHLTILVL 2937 Score = 124 bits (311), Expect = 8e-28 Identities = 263/1141 (23%), Positives = 402/1141 (35%), Gaps = 168/1141 (14%) Query: 188 SQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSP 247 SQ+ G GH TL ++ I C + A LQV+ P +L Sbjct: 2166 SQRTLLHGSGH--TLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPP----VLEPV 2219 Query: 248 SGRN---ILPGELVTLTCQVNS-SYPAVSSIKWLKDGVRLQTKT----GVLHLPQAAWSD 299 +N ++ G LV L C+ P VS W+KDG L +++ L L D Sbjct: 2220 EFQNDVVVVRGSLVELPCEARGVPLPLVS---WMKDGEPLLSQSLEQGPSLQLEAVGAGD 2276 Query: 300 AGVYTCQAENGVG--------SLVSPPISLHIFMA----EVQVSPAGPILENQTVTLVCN 347 +G Y+C A + G +++ PP HI + E+ ++P P+ L+C+ Sbjct: 2277 SGTYSCVAVSEAGEARRHFQLTVMEPP---HIEDSGQPTELSLTPGAPM------ELLCD 2327 Query: 348 TPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGS-ERSGPVSV 406 ++ +W+K+ L +++ + D G Y C ++ G+ E+S V V Sbjct: 2328 AQGTPQPNI--TWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRV 2385 Query: 407 VVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466 + P F+ A +L CSV +EP + G +L + Sbjct: 2386 QAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAH--------- 2436 Query: 467 GTSGPNSLR-LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLIS--PAAEVVE 523 T P R L+++ L DSG+Y C+A N+ G+ + + + S PA V Sbjct: 2437 -TQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSV 2495 Query: 524 GQAVTLSCRSGLSPTPDARFSWYLNGALLHEG-------PGSSLLLPAASSTDAGSYHCR 576 Q L C++ P P SW + L P SL + + DAG Y C Sbjct: 2496 NQTALLPCQADGVPAP--LVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCL 2553 Query: 577 ARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQL 636 A +SA L VL PP + L L A LL C P + Sbjct: 2554 A--SNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPA-----LLPCEASGSPKPLVVW 2606 Query: 637 LHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG 696 + + L G ++ + LL + P ++ + C SN +G Sbjct: 2607 WKDGQKLDFRLQQGA-----------YRLLPSNALL---LTAPGPQDSAQFECVVSNEVG 2652 Query: 697 NAST--SATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNGV---- 749 A T + T+ T+ LTC+ + G PA SW + G Sbjct: 2653 EAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCH----STGIPAPTVSWSKAGAQLGA 2708 Query: 750 ------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSA 803 + G LE LP+ A Y C AG V L+V P L + Sbjct: 2709 RGSGYRVSPSGALEIGQALPI---HAGRYTCSARNSAGVA-HKHVFLTVQASPVVKPLPS 2764 Query: 804 LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863 ++ L C P + +AT + QV G+ L + Sbjct: 2765 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ-----------LRI 2813 Query: 864 RELGLGDSGSYRCEATNVLGSS--NTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTG 921 D+G+Y C A N GS+ T L QV P EG L C+ G Sbjct: 2814 AHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKAR-G 2872 Query: 922 VPEGTSYRWYRDGQPLQEST-------SATLRFAAITLTQAGAYHCQAQAPGSATTSLAA 974 PE + W +DGQP+ + S L + AG Y C A+ +A Sbjct: 2873 SPE-PNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAE---NAVGRARR 2928 Query: 975 PISLHVSYAPRHVTLTTLMDTGPGRLG---LLLCRVDSDPPAQLRLLHGDRLVASTLQGV 1031 + L + P TTL RLG L C P ++ DR V +GV Sbjct: 2929 RVHLTILVLP---VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT---EGV 2982 Query: 1032 GGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF---DAQAVN 1088 +G S AV+ ED G Y+C A N +G+ A + +A + Sbjct: 2983 SEQDGGSTLQRAAVSR------------EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQ 3030 Query: 1089 VQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDG--------QQRLDAHSIPLPNVT 1140 + + G + L C+V + W +DG + +L S+ + Sbjct: 3031 GEAFSYLVEPVGGSIQLDCVVRGDPVPDIH--WIKDGLPLRGSHLRHQLQNGSLTIHRTE 3088 Query: 1141 VRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRP 1199 DA Y+C G A ++ + L + AP + G + C P Sbjct: 3089 RDDAGRYQCLAENEMGVAKKV---VILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEP 3145 Query: 1200 PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE 1259 + AG+ L +S L L + D G Y C A + LG A L + Sbjct: 3146 TPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3205 Query: 1260 G 1260 G Sbjct: 3206 G 3206 Score = 73.9 bits (180), Expect = 1e-12 Identities = 192/856 (22%), Positives = 301/856 (35%), Gaps = 132/856 (15%) Query: 842 PQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGA---W- 897 P +P Q + + L++ +G D G Y+C A + G +V W Sbjct: 257 PVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSPAGQQARDFQLRVHAPPTIWG 314 Query: 898 VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT-------LRFAAI 950 + + E V L C+ GVP + W++DG L ST L+ Sbjct: 315 SNETGEVAVMEDHLVQLLCEAR-GVPT-PNITWFKDGALLPTSTKVVYTRGGRQLQLGRA 372 Query: 951 TLTQAGAYHCQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDS 1009 + AG Y C+A A G+A + + Y P + G G ++ V Sbjct: 373 QSSDAGVYTCKASNAVGAAEKATRLDV-----YVPPTIE-------GAGGRPYVVKAVAG 420 Query: 1010 DPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA 1069 P A + G + G P S + + LRLE G G+Y C A Sbjct: 421 RPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEA--SSGLYSCVA 478 Query: 1070 SNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQL----------TY 1119 S+ G+A +V VQV P V EG L +T +V P +L T Sbjct: 479 SSPAGEAVLQ-----YSVEVQVPPQLLVAEG-LGQVTTIVG--QPLELPCQASGSPVPTI 530 Query: 1120 TWYQDG---------QQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLY 1170 W Q+G Q ++ + +V + + + C +++ + Sbjct: 531 QWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEW 590 Query: 1171 APRNLRLT-----YLLESHGGQLALVLCTVDS------RPPAQLALSHAGRLLASSTAAS 1219 AP L + + E H A V +PP G L T Sbjct: 591 APGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIP 650 Query: 1220 VPNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEA-------A 1270 V +L L++ RDEG Y+C+A + G++ + L+ V++ P A Sbjct: 651 VAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALK-----VLVPPNIEPGPVNKA 705 Query: 1271 VPEGAPITVTCADPAAHAPTLYTWYHNGR----WLQEGPAASLSFLV-----ATRAHAGA 1321 V E A +T+ C P + +W+ + W+ G S+ V A + AG+ Sbjct: 706 VLENASVTLECLASGVPPPDV-SWFKGHQPVSSWM--GVTVSVDGRVLRIEQAQLSDAGS 762 Query: 1322 YSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV-IQCTVDSEPPAELALS 1380 Y C A + G+ R L+V P+ + S + V + C P L Sbjct: 763 YRCVASNVAGSTELR-YGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWL 821 Query: 1381 HDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGR 1439 DG ++ + GT +QV L + A D Y C A + +G Sbjct: 822 KDGNPVSPA--------GTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV 873 Query: 1440 LQVEGARVVA--EPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTL- 1496 LQV + E + V ++ L C+ P PV +W+ + R L P L Sbjct: 874 LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV----LSWWKDGRPLEPRPGVHLS 929 Query: 1497 ---AFTHVARAQ---AGMYHCLAELPTGAAA---SAPVMLRVLYPPKTPTMMVFVEPEGG 1547 A V RA AG Y C A G + + V + ++P + + E G Sbjct: 930 ADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVRE---G 986 Query: 1548 LRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSD 1607 L C P ++ QP HV A L + L + Sbjct: 987 HPTSLSCECRGVPFPKISWR------KDGQPLPGEGAGLQHVSAVGRLLYLGQAQL--AQ 1038 Query: 1608 QGEYICSASNVLGSAS 1623 +G Y C SNV+G++S Sbjct: 1039 EGTYTCECSNVVGNSS 1054 Score = 64.7 bits (156), Expect = 7e-10 Identities = 141/589 (23%), Positives = 199/589 (33%), Gaps = 96/589 (16%) Query: 1100 GQLVNLTCLVWTTHPAQLTYTWYQDGQQRL----------DAHSIPLPNVTVRDATSYRC 1149 G V L C WT+ W +D Q L D + + V D Y+C Sbjct: 232 GADVELQC--WTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQC 289 Query: 1150 GVGPPGRAPRLSRPITLDV-----LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLA 1204 P A + +R L V ++ ++E H L +LC P + Sbjct: 290 VAFSP--AGQQARDFQLRVHAPPTIWGSNETGEVAVMEDH---LVQLLCEARGVPTPNIT 344 Query: 1205 LSHAGRLLASSTAASVPNTLR-LELRGPQPRDEGFYSCSARSPLGQANTSLELRL----- 1258 G LL +ST R L+L Q D G Y+C A + +G A + L + Sbjct: 345 WFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT 404 Query: 1259 ---EGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVAT 1315 G R + A G P+ + C +PTL +W+H G + E + L + Sbjct: 405 IEGAGGRPYVVKAVA---GRPVALECVARGHPSPTL-SWHHEGLPVAESNESRLETDGSV 460 Query: 1316 -------RAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCT 1368 A +G YSC A G + +++V PQ V Q T Sbjct: 461 LRLESPGEASSGLYSCVASSPAG-EAVLQYSVEVQVPPQLLVAEGLG----------QVT 509 Query: 1369 VDSEPPAELALSHDGKVLATSSGVHS--LASGTGHVQVARNALRLQVQDVPAGDD-TYVC 1425 P EL G + T + + A VQVA L + V + C Sbjct: 510 TIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFAC 569 Query: 1426 TAQNLLGSISTIGRLQVEGARVVAEPG-LDVPEG-------------AALNLSCRLLGGP 1471 A N G+ + V G PG L+VP G AA + G Sbjct: 570 QATNEAGTAGAEVEVSVHGEWA---PGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGA 626 Query: 1472 GPVGNSTFAWFWNDRRLHAEPV---------PTLAFTHVARAQAGMYHCLAELPTGAAAS 1522 P W + L EP P L V G+Y C A G + Sbjct: 627 HPKPPLVEGWC-SPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGES-K 684 Query: 1523 APVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAP 1582 V L+VL PP V L+C P ++ G + V+S Sbjct: 685 REVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSS------- 737 Query: 1583 AEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631 + V S + + IE + SD G Y C ASNV G ST +G+R Sbjct: 738 ---WMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG--STELRYGLR 781 Score = 47.4 bits (111), Expect = 1e-04 Identities = 82/328 (25%), Positives = 119/328 (36%), Gaps = 37/328 (11%) Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159 LL+K+L+ +D+G+Y E + V T++ + P T+ L G + Sbjct: 2902 LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL---PVFTTLPGDRSLRLGDRLWLR 2958 Query: 160 CSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQL 219 C+ R+ W D R VT E G L+ A+S +D G + C Sbjct: 2959 CAARG---SPTPRIGWTVND--RPVTEGVS--EQDGGSTLQ--RAAVSREDSGTYV-CWA 3008 Query: 220 SVANHRAQSEIHLQVKYAP----KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIK 275 R Q+ + VK AP + L+ P G +I L C V V I Sbjct: 3009 ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSI------QLDCVVRGD--PVPDIH 3060 Query: 276 WLKDGVRL-------QTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEV 328 W+KDG+ L Q + G L + + DAG Y C AEN +G I + Sbjct: 3061 WIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVF 3120 Query: 329 QVSPAG-PILENQTVTLVCNTPNEAPSDLRYSWYKNHVL----LEDAHSHTLRLHLATRA 383 QV P + V L C E + + + L +L L Sbjct: 3121 QVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETG 3180 Query: 384 DTGFYFCEVQNVHGSERSGPVSVVVNHP 411 D G Y C N+ GS + VV P Sbjct: 3181 DAGTYDCVAHNLLGSATARAFLVVRGEP 3208 >gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] Length = 5065 Score = 205 bits (522), Expect = 3e-52 Identities = 356/1491 (23%), Positives = 543/1491 (36%), Gaps = 255/1491 (17%) Query: 259 TLTCQVNSSYPAVSSIKWLKDGV------RLQTKTG--VLHLPQAAWSDAGVYTCQAENG 310 T++ Q + V +I WL++G+ RLQ VL + A +DA Y C AEN Sbjct: 2862 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ 2921 Query: 311 VGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLR------YSWYKNH 364 GS +F VQV P L+ + VT + N+ P D+ +WYK+ Sbjct: 2922 AGSAEK------LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDS 2975 Query: 365 VLLEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSERS-GPVSVVV----NHPP 412 L +HTL+L A +D+G Y CE N G ++ +SV+V P Sbjct: 2976 QALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAP 3035 Query: 413 LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPN 472 P + + G +L C + P T+ G L R G Sbjct: 3036 RGPQDAVLV--RVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQ-------RTQALRGGQ 3086 Query: 473 SLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE---GQAVTL 529 RLEI++ + +D G Y C +N G A T +P E V G + L Sbjct: 3087 --RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVL 3144 Query: 530 SCRSGLSPTPDARFSWY-----LNGALLH--EGPGSSLLLPAASSTDAGSYHCRARDGHS 582 +C +S P +W + + +H G L L AG+Y C A + + Sbjct: 3145 TC--DVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA 3202 Query: 583 ASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRV 642 + V+ VL PR + + G+ L C D PP + L Sbjct: 3203 EA--RKDFVVAVLVAPRIRSSGVAREHHVL---EGQEVRLDCEADGQPPPDVAWLKDGSP 3257 Query: 643 VATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSA 702 + + GG S +K +A + G Y C A N G + Sbjct: 3258 LGQDMGPHLRFYLDGG-SLVLKGLRA-------------SDAGAYTCVAHNPAGEDARLH 3303 Query: 703 TFNGQATVLAIAPSHTLQEGTEAN---------LTCNVSREAAGSPANFSWFRNGV---- 749 T N + + P T+++G + + L V P + SW ++G+ Sbjct: 3304 TVN-----VLVPP--TIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL 3356 Query: 750 ---LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLD 806 G T+ + V DA ++ C + AG L V PP + D Sbjct: 3357 SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGV-ADRNFTLQVQVPPVLEPVEFQND 3415 Query: 807 --MGQGHMALFICTVDSRPLALLA-LFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863 + +G + C PL L++ + GE LL+ SL Q PS L++ Sbjct: 3416 VVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSL-EQGPS--------------LQL 3460 Query: 864 RELGLGDSGSYRCEATNVLGSSNTSLFFQV-RGAWVQVSPSP---ELQEGQAVVLSCQVH 919 +G GDSG+Y C A + G + V ++ S P L G + L C Sbjct: 3461 EAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 3520 Query: 920 TGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSA-----TTSLAA 974 G P+ + W++DGQ L + + + + AG Y C A++P A + A Sbjct: 3521 -GTPQ-PNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQA 3578 Query: 975 PISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034 P ++ PR V + PG+L +L C V+++P ++ H D +V Sbjct: 3579 PPNIVGPRGPRFV-----VGLAPGQL-VLECSVEAEPAPKI-TWHRDGIVL--------- 3622 Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG 1094 H L++ D G Y C A N G S A V++ Sbjct: 3623 ---QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSV-------AFRVEIHTV 3672 Query: 1095 ATVREGQ-----LVNLTCLVWTTH---PAQLTYTWYQDGQ---------QRLDAHSIPLP 1137 T+R G VN T L+ PA L +W +D + L S+ + Sbjct: 3673 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLV-SWRKDRVPLDPRSPRFEILPEGSLRIQ 3731 Query: 1138 NVTVRDATSYRC------GVGPPGRAPRLSRPITLDVLYAPRNLRLT------YLLESHG 1185 V +DA Y C G GR R+ P + +P NL LT E+ G Sbjct: 3732 PVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPA--IAPSPSNLTLTAHTPALLPCEASG 3789 Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARS 1245 LV+ D + A RLL S+ L L P P+D + C + Sbjct: 3790 SPKPLVVWWKDGQKLDFRLQQGAYRLLPSNA---------LLLTAPGPQDSAQFECVVSN 3840 Query: 1246 PLGQANTSLELRLEGVRVILAPEAA-------VPEGAPITVTCADPAAHAPTLYTWYHNG 1298 +G+A+ RL V V + P A V AP+ +TC APT+ +W G Sbjct: 3841 EVGEAH-----RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTV-SWSKAG 3894 Query: 1299 RWL-------QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVL 1351 L + P+ +L A HAG Y+C A+++ G + + L V +P L Sbjct: 3895 AQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPL 3953 Query: 1352 SSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRL 1411 S + A ++ C P + +G +AT GV + G +++A + Sbjct: 3954 PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVAT--GVSTQVLPGGQLRIAHAS--- 4008 Query: 1412 QVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAE--PGLDVPEGAALNLSCRLLG 1469 P Y+C A+N GS RL V+ V+ P L EG+ L C+ G Sbjct: 4009 -----PEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARG 4063 Query: 1470 GPGPVGNSTFAWFWN---------DRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAA 1520 P P N T W+ + + +P L ++ AG Y C AE G A Sbjct: 4064 SPEP--NIT----WDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRA 4117 Query: 1521 ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQG 1580 V L +L P T+ G R L C P + + R V Sbjct: 4118 RRR-VHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG---- 4172 Query: 1581 APAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631 V + A+ D G Y+C A N +G ++ V+ Sbjct: 4173 --------VSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 4215 Score = 202 bits (513), Expect = 3e-51 Identities = 373/1573 (23%), Positives = 580/1573 (36%), Gaps = 263/1573 (16%) Query: 194 TGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNIL 253 + VG L L A Q+ C V N + ++ L+V P+ P+ +++ Sbjct: 2214 SAVGRLLYLGQAQLAQEGTYTCECSNVVGN--SSQDLQLEVHVPPQIAGPREPPTQVSVV 2271 Query: 254 PGELVTLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTC 305 + TL C P ++ W +DG ++LQ + LH+ +A + G Y+C Sbjct: 2272 QDGVATLECNATGKPPP--TVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 2329 Query: 306 QAENGVGSLVSPPISLHIFMAEVQVSPAGPILE-----NQTVTLVCNTPNEAPSDLRYSW 360 AEN G L + + + P+ + +TL+C P +R W Sbjct: 2330 VAENLAGR-AERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIR--W 2386 Query: 361 YKNHVLL---EDAH----SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413 ++ + ED + L++ D+G Y C N G R SV V PP Sbjct: 2387 FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRN-FSVEVLVPPS 2445 Query: 414 --TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGP 471 L ++ G L C+V P L G LA GD+ H P Sbjct: 2446 IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR--GDAHHI-------SP 2496 Query: 472 NSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAE-------VVEG 524 + + L++ + +G Y C A N++G T A ++ A + V Sbjct: 2497 DGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVN 2556 Query: 525 QAVTLSCRSGLSPTPDARFSWYLNGALLHEG------PGS-SLLLPAASSTDAGSYHCRA 577 ++L C + P+P+ +W +GA PG+ L + A DAG Y C Sbjct: 2557 NPISLICEALAFPSPN--ITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVV 2614 Query: 578 RDGHSASGPSSPAVLTVLYPPR--QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635 + + + + VL PP + + + L C + PP ++ Sbjct: 2615 TNELGEAVKNYH--VEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIR 2672 Query: 636 LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695 +KD T S R++V LL+++ + + G YLC A+N Sbjct: 2673 W-YKDGQPVTP-------------SSRLQVLGEGRLLQIQPTQ--VSDSGRYLCVATNVA 2716 Query: 696 GNASTS--------------ATFNGQATVLA--------IAPSHTLQEGTEANLTCNVSR 733 G F+ +L+ + + E A L C+ + Sbjct: 2717 GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTN- 2775 Query: 734 EAAGSPANFSWFRNGVLWAQGPLETVTL------LPVARTD-AALYACRILTEAGAQLST 786 A P + +W+R + G +V +P+ R + A Y+C+ E G Sbjct: 2776 --AIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 2833 Query: 787 PVLLSVLYPP----DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGP 842 LL VL PP D +L + + C P+ ++ + S Sbjct: 2834 YELL-VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRL 2892 Query: 843 QVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSP 902 QV G+ L+V + D+ SY C A N GS+ F +R VQV P Sbjct: 2893 QVLEDGQV----------LQVSTAEVADAASYMCVAENQAGSAEK--LFTLR---VQVPP 2937 Query: 903 ---SPELQEGQAVV-----LSCQVHTGV-PEGTSYRWYRDGQPLQESTSA-------TLR 946 +L++ A++ L C VH PE T WY+D Q L TL+ Sbjct: 2938 RIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT---WYKDSQALSLGEEVFLLPGTHTLQ 2994 Query: 947 FAAITLTQAGAYHCQA-QAPG--SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLL 1003 L+ +G Y C+A A G L+ + APR L+ G +L Sbjct: 2995 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDK--AVL 3052 Query: 1004 LCRVDSDP-PAQLRLLHGDRLV-ASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061 C D+ P P G LV A Q + G + RLEI A + D Sbjct: 3053 SCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ---------------RLEIQEAQVSD 3097 Query: 1062 EGVYICEASNTLGQASASADFDAQAVNVQVWPGA-TVRE--GQLVNLTCLVWTTHPAQLT 1118 +G+Y C+ SN G+A + Q P TV + G + LTC V + PA T Sbjct: 3098 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAP-T 3155 Query: 1119 YTWYQDGQQRLDAHSIPLPNVTVR------------DATSYRCGVGPPGRAPRLSRPITL 1166 TW +D R+ S + V R A +Y C R + + Sbjct: 3156 VTWLKD---RMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR--KDFVV 3210 Query: 1167 DVLYAPRNLRLTYLLESH---GGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT 1223 VL APR +R + + H GQ + C D +PP +A G L + Sbjct: 3211 AVLVAPR-IRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY 3269 Query: 1224 L---RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP---EAAVPEGAPI 1277 L L L+G + D G Y+C A +P G+ + RL V V++ P + A G + Sbjct: 3270 LDGGSLVLKGLRASDAGAYTCVAHNPAGE-----DARLHTVNVLVPPTIKQGADGSGTLV 3324 Query: 1278 T-----VTCADPAAHAPTLY-TWYHNG-------RWLQEGPAASLSFLVATRAHAGAYSC 1324 + VT P +P ++ +W +G R L G +L A AG ++C Sbjct: 3325 SRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC 3384 Query: 1325 QAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRA--RSMAVIQCTVDSEPPAELALSHD 1382 A G + R LQV P + D S+ + C P ++ D Sbjct: 3385 VAASPAGV-ADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD 3443 Query: 1383 GKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQ 1441 G+ L + SL G LQ++ V AGD TY C A + G +L Sbjct: 3444 GEPLLS----QSLEQGPS----------LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 3489 Query: 1442 VEGARVVAEPG----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLA 1497 V + + G L + GA + L C G P P W + + L + A Sbjct: 3490 VMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQP----NITWHKDGQALTRLENNSRA 3545 Query: 1498 FTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYP-----PKTPTMMVFVEPEGGLRGIL 1552 + AG+Y CLAE P GA + +RV P P+ P +V + P G L +L Sbjct: 3546 TRVLRVRDAGLYTCLAESPAGAIEKS-FRVRVQAPPNIVGPRGPRFVVGLAP-GQL--VL 3601 Query: 1553 DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612 +C V++EP +T H G + H + ++AL +D G+Y Sbjct: 3602 ECSVEAEPAPKITWH----------RDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYS 3651 Query: 1613 CSASNVLGSASTS 1625 C+A N GS S + Sbjct: 3652 CTARNAAGSTSVA 3664 Score = 201 bits (510), Expect = 7e-51 Identities = 379/1557 (24%), Positives = 563/1557 (36%), Gaps = 298/1557 (19%) Query: 258 VTLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTCQAEN 309 V+L C V++ +P + W KD V L T L L +A SD+G+YTC+A N Sbjct: 2955 VSLPCDVHA-HPN-PEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALN 3012 Query: 310 GVG---SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVL 366 G LV + + + P +L V + +A + +WYK+ Sbjct: 3013 AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQP 3072 Query: 367 LEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPP-LTPVLT 418 L A L + A +D G Y C+V NV G E ++ V PP T Sbjct: 3073 LVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKT 3131 Query: 419 AFLETQAGLVGILHCSVVSEPLATL--------VLSHGGHILASTSGDSDHSPRFSGTSG 470 + AG +L C V P T+ V S H + S G Sbjct: 3132 ETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGG------------- 3178 Query: 471 PNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN---AARLLISPAAE---VVEG 524 RL++ L+ +G Y C A N+ A DF A R+ S A V+EG Sbjct: 3179 ----RLQLSRLQPAQAGTYTCVAENTQAEARK--DFVVAVLVAPRIRSSGVAREHHVLEG 3232 Query: 525 QAVTLSCRSGLSPTPDARFSWYLNGALLHE--GP-------GSSLLLPAASSTDAGSYHC 575 Q V L C + P PD +W +G+ L + GP G SL+L ++DAG+Y C Sbjct: 3233 QEVRLDCEADGQPPPDV--AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 3290 Query: 576 RARDGHSASGPSSPA-VLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLL---CRVDSDPP 631 A H+ +G + + VL PP T + D +G R G L+ C V PP Sbjct: 3291 VA---HNPAGEDARLHTVNVLVPP-----TIKQGADGSGTLVSRPGELVTMVCPVRGSPP 3342 Query: 632 ARLQLL------------------HKDRVVATSLPSGGGCSTCGGCSPR--------MKV 665 + L H R+ L + G TC SP ++V Sbjct: 3343 IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQL-ADAGIFTCVAASPAGVADRNFTLQV 3401 Query: 666 TKAPNLLRVEIHNPLLEEEGLYL---CEASN----------------------------- 693 P L VE N ++ G + CEA Sbjct: 3402 QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLE 3461 Query: 694 ALGNASTSATFN-------GQAT----VLAIAPSHTLQEG--TEANLTCNVSRE----AA 736 A+G A S T++ G+A + + P H G TE +LT E A Sbjct: 3462 AVG-AGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 3520 Query: 737 GSPA-NFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP 795 G+P N +W ++G + + + DA LY C + AGA + + V P Sbjct: 3521 GTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGA-IEKSFRVRVQAP 3579 Query: 796 PD-----RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRF 850 P+ P+ L GQ + C+V++ P + +L Q P GRF Sbjct: 3580 PNIVGPRGPRFVVGLAPGQ---LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF 3636 Query: 851 QAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV----SPSPEL 906 L+++ L DSG Y C A N GS TS+ F+V V P+ + Sbjct: 3637 ----------LQLQALSTADSGDYSCTARNAAGS--TSVAFRVEIHTVPTIRSGPPAVNV 3684 Query: 907 QEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST-------SATLRFAAITLTQAGAYH 959 Q +L CQ GVP W +D PL + +LR + AG Y Sbjct: 3685 SVNQTALLPCQAD-GVP-APLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL 3742 Query: 960 CQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDP-PAQLRL 1017 C A + GS + + AP LT T LL C P P + Sbjct: 3743 CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTP----ALLPCEASGSPKPLVVWW 3798 Query: 1018 LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQAS 1077 G +L QG S+ L A P +D + C SN +G+A Sbjct: 3799 KDGQKLDFRLQQGAYRLLPSNALLLTAPGP------------QDSAQFECVVSNEVGEAH 3846 Query: 1078 ASADFDAQAVNVQVWPGATVREGQ----LVNLTCLVWTTHPAQL---TYTWYQDGQQRLD 1130 V V V P T+ + Q + + +V T H + T +W + G Q L Sbjct: 3847 R-----LYQVTVHVPP--TIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ-LG 3898 Query: 1131 AHSIPLPNVTVRDATSYRCGVGPPGRAPRLS-----------RPITLDVLYAPRNLRLTY 1179 A V + + G P A R + + + L V +P L Sbjct: 3899 ARG---SGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPS 3955 Query: 1180 LLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFY 1239 ++ + + L+ C P + G +A+ + V +L + P D G Y Sbjct: 3956 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNY 4015 Query: 1240 SCSARSPLGQA--NTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN 1297 C A++ G A T L +++ V P+ + EG+ + C + P + TW + Sbjct: 4016 LCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNI-TWDKD 4074 Query: 1298 GRWLQ--EG-----PAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAV 1350 G+ + EG P+ L AG Y+C A++A G R+ R L +L P Sbjct: 4075 GQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG-RARRRVHLTILVLPVFTT 4133 Query: 1351 LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR 1410 L R R ++C P + + + + + S V+R Sbjct: 4134 LPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSRE--- 4190 Query: 1411 LQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV---AEPGLDVPEGAALNLSCRL 1467 TYVC A+N +G + + V+ A V+ A L P G ++ L C + Sbjct: 4191 --------DSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV 4242 Query: 1468 LGGPGPVGNSTFAWFWNDRRL------HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAA 1521 G P P W + L H +L R AG Y CLAE G A Sbjct: 4243 RGDPVP----DIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAK 4298 Query: 1522 SAPVMLRVLYPPKTPTMMVF-VEPE-----GGLRGILDCRVDSEPLASLT-LHLGSRLVA 1574 +++ P VF VEP+ G L C+ EP ++ L G L A Sbjct: 4299 KVVILVLQSAP-------VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRA 4351 Query: 1575 SSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631 S + + P + +E + D G Y C A N+LGSA+ + VR Sbjct: 4352 SRRLRTLPDGS------------LWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 4396 Score = 199 bits (507), Expect = 1e-50 Identities = 379/1600 (23%), Positives = 553/1600 (34%), Gaps = 312/1600 (19%) Query: 210 DHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYP 269 D GR +C S AN ++ + L V+ AP+ + + S ++ G V ++C S YP Sbjct: 581 DGGRY-QCVASNANGVTRASVWLLVREAPQ---VSIHTSSQHFSQGVEVKVSCSA-SGYP 635 Query: 270 AVSSIKWLKDGVRLQTKT-------GVLHLPQAAWSDAGVYTCQAENGVGS-------LV 315 I W ++ LQ + G L + A DAG Y+CQA N VG+ Sbjct: 636 T-PHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY 694 Query: 316 SPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLL----EDAH 371 + P S+ A V V+ + LVC P R WY+ + + E + Sbjct: 695 TDPPSVSAVNAVVLVAVG------EEAVLVCEASGVPPP--RVIWYRGGLEMILAPEGSS 746 Query: 372 SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGIL 431 S LR+ A D G Y C N G + S + + V H P L + + G +L Sbjct: 747 SGKLRIPAAQERDAGTYTCRAVNELG-DASAEIQLAVGHAPQLTELPRDVTVELGRSALL 805 Query: 432 HCSVVSEPLATLVLSHG-GHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYK 490 C P T+ G G L G + R S + P+S L + D Y Sbjct: 806 ACRATGRPPPTVTWRRGDGQPLGLRLG----AGRGSRSRQPDSGVLFFESVAPEDQAPYV 861 Query: 491 CSATNSLGN----ATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWY 546 C A N G A + HA +P V+EGQ V+L C L+ P W Sbjct: 862 CEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIV-LAGRPLPERHWL 920 Query: 547 LNGALLHEGP------GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPR- 599 +G L G SL L A AG Y C A + +A L V PPR Sbjct: 921 KDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATN--TAGSQHRDVELVVQVPPRI 978 Query: 600 QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGC 659 PT T + + A L C V S PA K+ TS Sbjct: 979 HPTATHHITNEGVPAS------LPC-VASGVPAPTITWTKETNALTSR------------ 1019 Query: 660 SPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLA------- 712 P V+K LL I P ++ G Y+C A+N +G +S + L+ Sbjct: 1020 GPHYNVSKEGTLL---IAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEY 1076 Query: 713 -IAPSHTL-----QEGTEANLTCNVSREAA------------------------------ 736 + PS +L Q G + C S A Sbjct: 1077 GLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEA 1136 Query: 737 --------GSP-ANFSWFRNG-VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLST 786 G+P SW ++G VL +GP +V + +DA Y C AG + Sbjct: 1137 LDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVD-AW 1195 Query: 787 PVLLSVLYPP--DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQV 844 V L VL PP + S LL+ G A C P + G Sbjct: 1196 EVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGP--------SSE 1247 Query: 845 PSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSP 904 P HG+ A L + + DSG Y C+ATN +GS++ R A + V P Sbjct: 1248 PLHGQ-PGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTS-------RRAKLVVYVPP 1299 Query: 905 ELQE-----------GQAVVLSCQVH---------------TGVP-----EGTSYRWYRD 933 ++E GQ++ L C + GVP G W + Sbjct: 1300 SIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQV 1359 Query: 934 GQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLM 993 G +L F I +G Y C+A+ A H+ +T +++ Sbjct: 1360 GGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG-----TAQRDFHLLV----LTPPSVL 1410 Query: 994 DTGPGR--LGL------LLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAV 1045 G + LGL L C P Q+ + V GGP H+ V Sbjct: 1411 GAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLP-----GGP-------HLQV 1458 Query: 1046 APNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG-----ATVREG 1100 + L I G+ + DEG Y C A + GQ + A +W V E Sbjct: 1459 QEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT-IWGSNETGEVAVMED 1517 Query: 1101 QLVNLTCLVWTTHPAQLTYTWYQDGQ---------QRLDAHSIPLPNVTVRDATSYRC-- 1149 LV L C + TW++DG + L DA Y C Sbjct: 1518 HLVQLLCEARGVPTPNI--TWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKA 1575 Query: 1150 --GVGPPGRAPRLSRPITLDVLYAPRNLR----LTYLLESHGGQLALVLCTVDSRPPAQL 1203 VG +A RL +Y P + Y++++ G+ + C P L Sbjct: 1576 SNAVGAAEKATRLD-------VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL 1628 Query: 1204 ALSHAGRLLASSTAASVP---NTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG 1260 + H G +A S + + + LRLE P G YSC A SP G+A + ++ Sbjct: 1629 SWHHEGLPVAESNESRLETDGSVLRLE--SPGEASSGLYSCVASSPAGEAVLQYSVEVQV 1686 Query: 1261 VRVILAPE----AAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQE-------GPAASL 1309 +L E G P+ + C + PT+ W NGR +E +L Sbjct: 1687 PPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTI-QWLQNGRPAEELAGVQVASQGTTL 1745 Query: 1310 SFLVATRAHAGAYSCQAQDAQGTRSSR----------PAALQVLYAPQDAVLSSFRDSRA 1359 H+G ++CQA + GT + P L+V A Sbjct: 1746 HIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPA 1805 Query: 1360 RSMAVIQ--CTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVP 1417 + +PP G + +G+ S +Q+ + LR Sbjct: 1806 ACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLR------- 1858 Query: 1418 AGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPG---LDVPEGAALNLSCRLLGGPGPV 1474 + Y C A NL G L+V + EPG V E A++ L C G P P Sbjct: 1859 -DEGIYTCAATNLAGESKREVALKVLVPPNI-EPGPVNKAVLENASVTLECLASGVPPP- 1915 Query: 1475 GNSTFAWFWNDRRLHAEPVPTLA----FTHVARAQ---AGMYHCLA-------ELPTGAA 1520 +WF + + + T++ + +AQ AG Y C+A EL G Sbjct: 1916 ---DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLR 1972 Query: 1521 ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQG 1580 + P R+ PP P ++ P L C P +L + P Sbjct: 1973 VNVPP--RITLPPSLPGPVLVNTPVR-----LTCNATGAPSPTL------MWLKDGNPVS 2019 Query: 1581 APAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620 P + V P + + + R SD G Y C A + +G Sbjct: 2020 PAGTPGLQVF--PGGRVLTLASARASDSGRYSCVAVSAVG 2057 Score = 191 bits (485), Expect = 5e-48 Identities = 366/1491 (24%), Positives = 540/1491 (36%), Gaps = 263/1491 (17%) Query: 270 AVSSIKWLKDGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQ 329 A+S W + G+ +G L L Q D+G Y C A N GS + H ++ VQ Sbjct: 1067 ALSKYVWEEYGL---LPSGSLRLAQVQVGDSGHYECTASNPAGS------ASHRYVLGVQ 1117 Query: 330 VSPA---GP----ILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATR 382 V P GP +L + + L C E + + SW K+ V+L+ A R Sbjct: 1118 VPPQVQPGPRVLKVLVGEALDLNCVA--EGNPEPQLSWSKDGVVLQGRGPQGSVHFAAIR 1175 Query: 383 -ADTGFYFCEVQNVHGSERSGPVSVVVNHPPL--TPVLTAFLETQAGLVGILHCSVVSEP 439 +D G Y CE N G + + V + V PP + LE AG L C P Sbjct: 1176 TSDAGRYRCEASNSAGVD-AWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTP 1234 Query: 440 LATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGN 499 + G S + H G + L + + DSG+Y+C ATN +G+ Sbjct: 1235 KPQVTWRKG------PSSEPLHGQ--PGVAVLEEGSLFLASVSPADSGDYECQATNEVGS 1286 Query: 500 ATSTLDFHANAARLLISPAAEVVE-----------GQAVTLSCRSGLSPTPD-------- 540 + A+L++ + E GQ++TL C + P P+ Sbjct: 1287 T-------SRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQ 1339 Query: 541 --------ARFSWYLNGA------LLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGP 586 A + W L LL E G SL P D+G Y CRA + A Sbjct: 1340 LVGVPLGWAGYGWDLGWGQVGGHRLLDE--GQSLHFPRIQEGDSGLYSCRAE--NQAGTA 1395 Query: 587 SSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVD-------SDPPARLQLLHK 639 L VL PP GAGA + L L D S P K Sbjct: 1396 QRDFHLLVLTPP-----------SVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTK 1444 Query: 640 DRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNAS 699 DR LP G P ++V + +LR I + +EG Y C A + G + Sbjct: 1445 DR--QPVLPGG----------PHLQVQEDGQVLR--ITGSHVGDEGRYQCVAFSPAGQQA 1490 Query: 700 TSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNG--------VL 750 A + T + + + EA G P N +WF++G V+ Sbjct: 1491 RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVV 1550 Query: 751 WAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQG 810 + +G + + L +DA +Y C+ GA L V PP G G Sbjct: 1551 YTRGGRQ-LQLGRAQSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIE--------GAG 1600 Query: 811 HMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLE-------V 863 + V RP+AL + G P + H AE+N +LE + Sbjct: 1601 GRPYVVKAVAGRPVALECVARGHP------SPTLSWHHEGLPVAESNESRLETDGSVLRL 1654 Query: 864 RELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE---------GQAVVL 914 G SG Y C A++ G + L + V VQV P + E GQ + L Sbjct: 1655 ESPGEASSGLYSCVASSPAGEA--VLQYSVE---VQVPPQLLVAEGLGQVTTIVGQPLEL 1709 Query: 915 SCQVHTGVPEGTSYRWYRDGQPLQE-------STSATLRFAAITLTQAGAYHCQAQAPGS 967 CQ +G P T +W ++G+P +E S TL + L +G + CQA + Sbjct: 1710 PCQA-SGSPVPT-IQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA-TNEA 1766 Query: 968 ATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRL-LHGDRLVAS 1026 T +S+H +AP V + G DPP H + Sbjct: 1767 GTAGAEVEVSVHGEWAP-GVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVE 1825 Query: 1027 TLQGVGGPEGSSPRLHVAVA-PNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQ 1085 G G + VA + P L++E L DEG+Y C A+N G++ Sbjct: 1826 GWCSPGSLWGEPTGIPVAYSLPPPLQIE--KVDLRDEGIYTCAATNLAGESKREVALKVL 1883 Query: 1086 A-VNVQVWP-GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ---------RLDAHSI 1134 N++ P V E V L CL P + +W++ Q +D + Sbjct: 1884 VPPNIEPGPVNKAVLENASVTLECLASGVPPPDV--SWFKGHQPVSSWMGVTVSVDGRVL 1941 Query: 1135 PLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV---LYAPRNLRLTYLLESHGGQLALV 1191 + + DA SYRC + L + ++V + P +L L+ + + Sbjct: 1942 RIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP----VRL 1997 Query: 1192 LCTVDSRPPAQLALSHAGRLLASSTAASV---PNTLRLELRGPQPRDEGFYSCSARSPLG 1248 C P L G ++ + + P L L + D G YSC A S +G Sbjct: 1998 TCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG 2057 Query: 1249 QANTSLELRLEGVRVILAPE--AAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPA 1306 + + L++ IL E +V + + C A P L +W+ +GR L+ P Sbjct: 2058 EDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVL-SWWKDGRPLEPRPG 2116 Query: 1307 ASLS----FLVATRA---HAGAYSCQAQDAQGTRSSRPAALQVLYAP----QDAVLSSFR 1355 LS L RA AG Y+C+A + G S + L V AP +++ + R Sbjct: 2117 VHLSADKALLQVDRADVWDAGHYTCEALNQAG-HSEKHYNLNVWVAPVFPLRESHTLTVR 2175 Query: 1356 DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQD 1415 + S++ C P +++ DG+ L +G HV L L Q Sbjct: 2176 EGHPTSLS---CECRGVPFPKISWRKDGQPLPGE------GAGLQHVSAVGRLLYLG-QA 2225 Query: 1416 VPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEP-----GLDVPEGAALNLSCRLLGG 1470 A + TY C N++G+ S +L+V +A P + V + L C G Sbjct: 2226 QLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGK 2285 Query: 1471 PGPVGNSTFAWFWNDRRLHAEPVPTL----AFTHVARAQA---GMYHCLAELPTGAAASA 1523 P P T W + + + AE L HV RAQA G Y C+AE G A Sbjct: 2286 PPP----TVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG-RAER 2340 Query: 1524 PVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQG--- 1580 L VL PP+ L G LD PL ++T L S L + G Sbjct: 2341 KFELSVLVPPE-------------LIGDLD------PLTNITAALHSPLTLLCEAMGIPP 2381 Query: 1581 ---------APAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622 P P + + + D G Y C ASN G A Sbjct: 2382 PAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEA 2432 Score = 179 bits (454), Expect = 2e-44 Identities = 398/1681 (23%), Positives = 604/1681 (35%), Gaps = 297/1681 (17%) Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRV---PTIASPVELLEGTEV 156 L ++ Q D+GSY R S V ++++ L V PR+ P++ PV L T V Sbjct: 1941 LRIEQAQLSDAGSY--RCVASNVAGSTELRYGL-RVNVPPRITLPPSLPGPV--LVNTPV 1995 Query: 157 DFNCSTPYVCLQEQVRLQW--QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRI 214 C+ L W G + + T Q F G + TL A + D GR Sbjct: 1996 RLTCNATGA---PSPTLMWLKDGNPVSPAGTPGLQVFPG---GRVLTLASARA-SDSGRY 2048 Query: 215 LRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSI 274 +S Q ++ LQV P IL +++ E V L CQ ++ P V S Sbjct: 2049 SCVAVSAVGEDRQ-DVVLQVHMPPS---ILGEELNVSVVANESVALECQSHAMPPPVLS- 2103 Query: 275 KWLKDGVRLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA 326 W KDG L+ + GV L + +A DAG YTC+A N G S + Sbjct: 2104 -WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGH------SEKHYNL 2156 Query: 327 EVQVSPAGPILENQTVTLVCNTPNEAPSDLR------YSWYKNHVLLE---------DAH 371 V V+P P+ E+ T+T+ P + R SW K+ L A Sbjct: 2157 NVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAV 2216 Query: 372 SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTP----VLTAFLETQAGL 427 L L A A G Y CE NV G+ S + + V+ PP T Q G Sbjct: 2217 GRLLYLGQAQLAQEGTYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDG- 2274 Query: 428 VGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487 V L C+ +P T+ G + + G + S L + + +G Sbjct: 2275 VATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQS---------LHVERAQAAHTG 2325 Query: 488 EYKCSATNSLGNATSTLDFHANAARLLIS---PAAEVVEG--QAVTLSCRSGLSPTPDAR 542 Y C A N G A + LI P + +TL C + P P R Sbjct: 2326 RYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIR 2385 Query: 543 FSWYLNGALLHEGPGSSLL-------LPAASSTDAGSYHCRARDGHSASGPSSPAVLTVL 595 W+ + G + LL + D+G Y C A + A + VL Sbjct: 2386 --WFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA--SNEAGEARRNFSVEVL 2441 Query: 596 YPPRQPTFTTRLDLDAA-GAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCS 654 PP DL+ G+ L+C V P +L R +A Sbjct: 2442 VPPS----IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR--------- 2488 Query: 655 TCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIA 714 G + + +P+ + +++ L G Y C A+NA+G T + Q +VL +A Sbjct: 2489 ---GDAHHI----SPDGVLLQVLQANLSSAGHYSCIAANAVG----EKTKHFQLSVL-LA 2536 Query: 715 PS--HTLQEGTEANLTCNVSR------EAAGSPA-NFSWFRNGVLWAQGPLETVTLLP-- 763 P+ ++ + +T V+ EA P+ N +W ++G + + LLP Sbjct: 2537 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEAS--RNIQLLPGT 2594 Query: 764 -------VARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFI 816 + DA Y C + E G + + VL PP K L ++G + + Sbjct: 2595 HGLQILNAQKEDAGQYTCVVTNELGEAVKN-YHVEVLIPPSISKDDPLGEVGVKEVKTKV 2653 Query: 817 -------CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869 C + P + + + S QV GR L+++ + Sbjct: 2654 NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL----------LQIQPTQVS 2703 Query: 870 DSGSYRCEATNVLGSSNTSL--------FFQVRG--------------AWVQVSPSPELQ 907 DSG Y C ATNV G + FQ G A V+ E+ Sbjct: 2704 DSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIV 2763 Query: 908 EGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT-------LRFAAITLTQAGAYHC 960 E L C + P + WYR+ QPL + L+ + AG Y C Sbjct: 2764 ENNPAYLYCDTNAIPPPDLT--WYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSC 2821 Query: 961 QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020 +A ++ LH Y +T ++ + + S Q L Sbjct: 2822 KA-------SNEVGEDWLH--YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN 2872 Query: 1021 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080 S LQ G P SPRL V L++ A + D Y+C A N G A Sbjct: 2873 PVPTISWLQN-GLPFSPSPRLQVLEDGQV--LQVSTAEVADAASYMCVAENQAGSAE--- 2926 Query: 1081 DFDAQAVNVQVWP--------GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL--- 1129 + VQV P T V+L C V HP TWY+D Q Sbjct: 2927 --KLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDV-HAHP-NPEVTWYKDSQALSLGE 2982 Query: 1130 ------DAHSIPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVL------YAPRNLR 1176 H++ L + D+ Y C + GR +L + L VL APR + Sbjct: 2983 EVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL---VQLSVLVPPAFRQAPRGPQ 3039 Query: 1177 LTYLLESHGGQLALVLCTVDSRPPAQLALSHAGR-LLASSTAASVPNTLRLELRGPQPRD 1235 L+ G A++ C D+ P + G+ L+ + ++ RLE++ Q D Sbjct: 3040 DAVLVRV--GDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSD 3097 Query: 1236 EGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE---GAPITVTCADPAAHAPTLY 1292 +G YSC + G+A + L ++ P+ G+P+ +TC APT+ Sbjct: 3098 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV- 3156 Query: 1293 TWYHNGRWLQEGP-------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYA 1345 TW + ++ L A AG Y+C A++ Q + + + VL A Sbjct: 3157 TWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQ-AEARKDFVVAVLVA 3215 Query: 1346 PQDAVLSSFRDSRARSMAVIQ--CTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403 P+ R+ ++ C D +PP ++A DG L G H G Sbjct: 3216 PRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSL 3275 Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV-------EGA----RVVAEPG 1452 V + L+ D A Y C A N G + + + V +GA +V+ P Sbjct: 3276 VLKG---LRASDAGA----YTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRP- 3327 Query: 1453 LDVPEGAALNLSCRLLGGPGPVGNSTFAWF-------WNDRRLHAEPVPTLAFTHVARAQ 1505 G + + C + G P P+ S W + R L TL + V A Sbjct: 3328 -----GELVTMVCPVRGSP-PIHVS---WLKDGLPLPLSQRTLLHGSGHTLRISKVQLAD 3378 Query: 1506 AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI---LDCRVDSEPLA 1562 AG++ C+A P G A L+V PP + F +RG L C PL Sbjct: 3379 AGIFTCVAASPAG-VADRNFTLQVQVPPVLEP-VEFQNDVVVVRGSLVELPCEARGVPLP 3436 Query: 1563 SLT-LHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621 ++ + G L++ S QG + +EA+ D G Y C A + G Sbjct: 3437 LVSWMKDGEPLLSQSLEQGP---------------SLQLEAVGAGDSGTYSCVAVSEAGE 3481 Query: 1622 A 1622 A Sbjct: 3482 A 3482 Score = 176 bits (445), Expect = 2e-43 Identities = 378/1579 (23%), Positives = 578/1579 (36%), Gaps = 296/1579 (18%) Query: 200 ETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVT 259 ++LH+ + H C RA+ + L V P+ + L + +T Sbjct: 2312 QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLT 2371 Query: 260 LTCQVNSSYPAVSSIKWLK--------DGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGV 311 L C+ P +I+W + + L +L + Q D+G+Y+C A N Sbjct: 2372 LLCEAMGIPPP--AIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEA 2429 Query: 312 GSLVSPPISLHIFMAEVQVSPAGP---------ILENQTVTLVCNTPNEAPSDLRYSWYK 362 G + F EV V P+ +L+ QT L+CN L +W+K Sbjct: 2430 GE------ARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFK 2481 Query: 363 NHVLLEDAHSH-------TLRLHLATRADTGFYFCEVQNVHGSE-RSGPVSVVVNHPPLT 414 + L +H L++ A + G Y C N G + + +SV+ L Sbjct: 2482 DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL-----LA 2536 Query: 415 PVLTAFLETQAG---LVGI-----LHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466 P + E A V + L C ++ P + G + S + Sbjct: 2537 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEA----SRNIQLLP 2592 Query: 467 GTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA-------- 518 GT G L+I + ++ D+G+Y C TN LG A ++H +LI P+ Sbjct: 2593 GTHG-----LQILNAQKEDAGQYTCVVTNELGEAVK--NYH---VEVLIPPSISKDDPLG 2642 Query: 519 ------AEVVEGQAVTLSCRSGLSPTPDARFSWYLNG-------ALLHEGPGSSLLLPAA 565 + +TL C S P P R WY +G L G G L + Sbjct: 2643 EVGVKEVKTKVNSTLTLECESWAVPPPTIR--WYKDGQPVTPSSRLQVLGEGRLLQIQPT 2700 Query: 566 SSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP---RQPTFTTRLDL-----DAAGAGAG 617 +D+G Y C A + ++ V PP + F+ ++ +A G Sbjct: 2701 QVSDSGRYLCVATNVAGEDDQDFNVLIQV--PPMFQKVGDFSAAFEILSREEEARGGVTE 2758 Query: 618 RRGL-------LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPN 670 R + L C ++ PP L +D+ L +G S G +V + P Sbjct: 2759 YREIVENNPAYLYCDTNAIPPPDLTWYREDQ----PLSAGDEVSVLQG----GRVLQIP- 2809 Query: 671 LLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCN 730 L+R E G Y C+ASN +G + + + L E N + Sbjct: 2810 LVRA-------ENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASST 2862 Query: 731 VSRE--AAGSPA-NFSWFRNGVLWAQGP----LETVTLLPVAR---TDAALYACRILTEA 780 VS + A G+P SW +NG+ ++ P LE +L V+ DAA Y C +A Sbjct: 2863 VSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQA 2922 Query: 781 GAQLSTPVLLSVLYPP-----DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHL 835 G+ L V PP D +++A+L+ C V + P + + Sbjct: 2923 GS-AEKLFTLRVQVPPRIAGLDLEQVTAILNSS----VSLPCDVHAHPNPEVTWYKDSQ- 2976 Query: 836 LATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN--TSLFFQV 893 A SLG +V + L++ L DSG Y CEA N G L V Sbjct: 2977 -ALSLGEEV--------FLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV 3027 Query: 894 RGAWVQVSPSPE----LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP--LQESTSA---- 943 A+ Q P+ ++ G VLSC+ +PE T WY+DGQP L + T A Sbjct: 3028 PPAFRQAPRGPQDAVLVRVGDKAVLSCET-DALPEPT-VTWYKDGQPLVLAQRTQALRGG 3085 Query: 944 -TLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYA-PRHVTLTTLMDTGPGRL 1000 L ++ G Y C+ + G A + + + ++ P+ T++ + G Sbjct: 3086 QRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQV----AGSP 3141 Query: 1001 GLLLCRVDSDPPAQLRLLHGDRL--VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAM 1058 +L C V P + L DR+ +S + GV G RL++ Sbjct: 3142 LVLTCDVSGVPAPTVTWLK-DRMPVESSAVHGVVSRGG--------------RLQLSRLQ 3186 Query: 1059 LEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGAT---------VREGQLVNLTCLV 1109 G Y C A NT QA A DF V V V P V EGQ V L C Sbjct: 3187 PAQAGTYTCVAENT--QAEARKDF---VVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEA 3241 Query: 1110 WTTHPAQLTYTWYQDGQQ-----------RLDAHSIPLPNVTVRDATSYRC-GVGPPGRA 1157 P + W +DG LD S+ L + DA +Y C P G Sbjct: 3242 DGQPPPDV--AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 3299 Query: 1158 PRLSRPITLDVLYAP---RNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLAS 1214 RL T++VL P + + L S G+L ++C V PP ++ G L Sbjct: 3300 ARLH---TVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL 3356 Query: 1215 STAASVPNT-LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP-----E 1268 S + + L + Q D G ++C A SP G A+ + L+++ V +L P + Sbjct: 3357 SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ-VPPVLEPVEFQND 3415 Query: 1269 AAVPEGAPITVTCADPAAHAPTLYTWYHNG-----RWLQEGPAASLSFLVATRAHAGAYS 1323 V G+ + + C P L +W +G + L++GP+ L + A +G YS Sbjct: 3416 VVVVRGSLVELPCEARGVPLP-LVSWMKDGEPLLSQSLEQGPSLQLEAVGA--GDSGTYS 3472 Query: 1324 CQAQDAQGTRSSRPAALQVLYAP--QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSH 1381 C A G + R L V+ P +D+ + + + C P + Sbjct: 3473 CVAVSEAG-EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK 3531 Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQ 1441 DG+ L T +R L+V+D Y C A++ G+I R+ Sbjct: 3532 DGQAL------------TRLENNSRATRVLRVRDA----GLYTCLAESPAGAIEKSFRV- 3574 Query: 1442 VEGARVVAEPGLDVPEG---------AALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP 1492 RV A P + P G L L C + P P W D + E Sbjct: 3575 ----RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAP----KITWH-RDGIVLQED 3625 Query: 1493 VPT--------LAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLY--PPKTPTMMVFV 1542 T L ++ A +G Y C A AA S V RV P + V Sbjct: 3626 AHTQFPERGRFLQLQALSTADSGDYSCTAR---NAAGSTSVAFRVEIHTVPTIRSGPPAV 3682 Query: 1543 EPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEA 1602 +L C+ D P A L R+ P P +L +LR I+ Sbjct: 3683 NVSVNQTALLPCQADGVP-APLVSWRKDRVPLD------PRSPRFEILPE-GSLR--IQP 3732 Query: 1603 LRPSDQGEYICSASNVLGS 1621 + D G Y+C ASN GS Sbjct: 3733 VLAQDAGHYLCLASNSAGS 3751 Score = 162 bits (410), Expect = 3e-39 Identities = 332/1384 (23%), Positives = 488/1384 (35%), Gaps = 253/1384 (18%) Query: 252 ILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTG--------VLHLPQAAWSDAGVY 303 + PGE L+C+V P ++ W++D L TG L + +D G Y Sbjct: 528 VSPGETAVLSCRVLGEAPY--NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRY 585 Query: 304 TCQAENGVGSL---------VSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPS 354 C A N G +P +S+H + + + V + C+ Sbjct: 586 QCVASNANGVTRASVWLLVREAPQVSIH--------TSSQHFSQGVEVKVSCSASGYPTP 637 Query: 355 DLRYSWYKNHVLLEDAHSH-----TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVN 409 + +S ++ L ED+ H TL + D G Y C+ N G+++ V++ Sbjct: 638 HISWS-RESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQE-TVTLYYT 695 Query: 410 HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGG--HILASTSGDSDHSPRFSG 467 PP + A + G +L C P ++ GG ILA Sbjct: 696 DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP------------- 742 Query: 468 TSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFH-ANAARLLISPAAEVVE-GQ 525 G +S +L I +E D+G Y C A N LG+A++ + +A +L P VE G+ Sbjct: 743 -EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGR 801 Query: 526 AVTLSCRSGLSPTPDA---RFSWYLNGALLHEGPGSS--------LLLPAASSTDAGSYH 574 + L+CR+ P P R G L G GS L + + D Y Sbjct: 802 SALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYV 861 Query: 575 CRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARL 634 C AR+ + ++T PP+ + G+ L C V + P Sbjct: 862 CEARNVFGKVQAEARLIVTGHAPPQIAS-----SAPTVRVLEGQPVSLPCIVLAGRPLPE 916 Query: 635 QLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNA 694 + KD LP G S S + + L E G Y C A+N Sbjct: 917 RHWLKD---GRPLPPGSRHSIRADGS-------------LHLDRALQEHAGRYSCVATNT 960 Query: 695 LGNASTSATFNGQA--TVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFR-NGVL 750 G+ Q + A H EG A+L C A+G PA +W + L Sbjct: 961 AGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPC----VASGVPAPTITWTKETNAL 1016 Query: 751 WAQGPLETV----TLL---PVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSA 803 ++GP V TLL P A+ DA Y C G S + LSV Sbjct: 1017 TSRGPHYNVSKEGTLLIAQPSAQ-DAGAYVCTATNTVGFS-SQEMRLSV----------- 1063 Query: 804 LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863 LAL E+ L S SL+L Sbjct: 1064 ------------------NRLALSKYVWEEYGLLPS-----------------GSLRL-- 1086 Query: 864 RELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE---GQAVVLSCQVHT 920 ++ +GDSG Y C A+N GS++ V+ QV P P + + G+A+ L+C V Sbjct: 1087 AQVQVGDSGHYECTASNPAGSASHRYVLGVQ-VPPQVQPGPRVLKVLVGEALDLNC-VAE 1144 Query: 921 GVPEGTSYRWYRDGQPLQ-ESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLH 979 G PE W +DG LQ ++ FAAI + AG Y C+A A + L Sbjct: 1145 GNPE-PQLSWSKDGVVLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVD---AWEVELR 1200 Query: 980 VSYAPRHVTLTT--LMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGS 1037 V P T L++ G L C P Q+ G + L G G Sbjct: 1201 VLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPS--SEPLHGQPG---- 1254 Query: 1038 SPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF----------DAQAV 1087 VAV L + D G Y C+A+N +G S A D + Sbjct: 1255 -----VAVLEEG-SLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKA 1308 Query: 1088 NVQVWPGAT-----------------VREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL- 1129 NV G + +++ QLV + L W + L W Q G RL Sbjct: 1309 NVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVP-LGWAGYGWDL--GWGQVGGHRLL 1365 Query: 1130 -DAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHG--G 1186 + S+ P + D+ Y C +A R L VL P L E G G Sbjct: 1366 DEGQSLHFPRIQEGDSGLYSCRA--ENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAG 1423 Query: 1187 QLALVLCTVDSRPPAQLALSHAGR-LLASSTAASVPNTLR-LELRGPQPRDEGFYSCSAR 1244 + C P Q+ + + +L V + L + G DEG Y C A Sbjct: 1424 ADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAF 1483 Query: 1245 SPLGQANTSLELRLEGVRVILAP----EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRW 1300 SP GQ +LR+ I E AV E + + C P + TW+ +G Sbjct: 1484 SPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNI-TWFKDGAL 1542 Query: 1301 LQEGP-------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSS 1353 L L A + AG Y+C+A +A G ++ A +Y P + Sbjct: 1543 LPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG--AAEKATRLDVYVPPTIEGAG 1600 Query: 1354 FRDSRARSMA----VIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNAL 1409 R +++A ++C P L+ H+G +A S+ ++ + L Sbjct: 1601 GRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESN--------ESRLETDGSVL 1652 Query: 1410 RLQVQDVPAGDDTYVCTAQNLLGS--ISTIGRLQVEGARVVAEPGLDVPE--GAALNLSC 1465 RL+ A Y C A + G + +QV +VAE V G L L C Sbjct: 1653 RLE-SPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPC 1711 Query: 1466 RLLGGPGPVGNSTFAWFWNDRRLH-------AEPVPTLAFTHVARAQAGMYHCLAELPTG 1518 + G P P T W N R A TL HV +G++ C A G Sbjct: 1712 QASGSPVP----TIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 1767 Query: 1519 AAAS 1522 A + Sbjct: 1768 TAGA 1771 Score = 157 bits (398), Expect = 6e-38 Identities = 385/1708 (22%), Positives = 608/1708 (35%), Gaps = 308/1708 (18%) Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159 L+++ + PED+G+Y+ + +EV +D + + T+ P V + + V + G E Sbjct: 662 LIIQGVAPEDAGNYSCQ-ATNEVG--TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 718 Query: 160 CSTPYVCLQEQVRLQWQGQDPARSVTFNS---QKFEPTGVGHLETLHMAMSWQDHGRILR 216 C G P R + + P G + A +D G Sbjct: 719 CEA-------------SGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYT- 764 Query: 217 CQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW 276 C+ A +EI L V +AP+ ++ P + G L C+ P ++ W Sbjct: 765 CRAVNELGDASAEIQLAVGHAPQLTEL---PRDVTVELGRSALLACRATGRPPP--TVTW 819 Query: 277 LKD-----GVRL---------QTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLH 322 + G+RL Q +GVL A D Y C+A N G + + + Sbjct: 820 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 879 Query: 323 IFMAEVQVSPAGP---ILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLR--- 376 A Q++ + P +LE Q V+L C P R+ W K+ L H++R Sbjct: 880 TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH-WLKDGRPLPPGSRHSIRADG 938 Query: 377 -LHL--ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHC 433 LHL A + G Y C N GS+ VV P + P T + T G+ L C Sbjct: 939 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHI-TNEGVPASLPC 997 Query: 434 SVVSEPLATL--------VLSHGGHILAS------------------------TSGDSDH 461 P T+ + S G H S T G S Sbjct: 998 VASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQ 1057 Query: 462 SPRFS--------------GTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFH 507 R S G SLRL ++ DSG Y+C+A+N G+A+ H Sbjct: 1058 EMRLSVNRLALSKYVWEEYGLLPSGSLRLA--QVQVGDSGHYECTASNPAGSAS-----H 1110 Query: 508 ANAARLLISPAAE-------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH-EGPGSS 559 + + P + V+ G+A+ L+C + +P P + SW +G +L GP S Sbjct: 1111 RYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEP--QLSWSKDGVVLQGRGPQGS 1168 Query: 560 LLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRR 619 + A ++DAG Y C A +SA + L VL PP T L+ AG Sbjct: 1169 VHFAAIRTSDAGRYRCEA--SNSAGVDAWEVELRVLEPPHWGADETSGLLERV---AGEN 1223 Query: 620 GLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNP 679 L C P ++ R +S P G P + V + +L + Sbjct: 1224 ASLPCPARGTPKPQVTW----RKGPSSEPLHG--------QPGVAVLEEGSLFLASVSPA 1271 Query: 680 LLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLT------CNVSR 733 + G Y C+A+N +G+ S +A ++ P ++G +AN++ + Sbjct: 1272 ---DSGDYECQATNEVGSTSR------RAKLVVYVPPSIREDGRKANVSGMAGQSLTLEC 1322 Query: 734 EAAGSPA-NFSWFRNGVL---------------WAQ-------GPLETVTLLPVARTDAA 770 +A G P W ++ L W Q +++ + D+ Sbjct: 1323 DANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSG 1382 Query: 771 LYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALF 830 LY+CR +AG LL VL PP ++L G L + D + Sbjct: 1383 LYSCRAENQAGTAQRDFHLL-VLTPP------SVLGAGAAQEVLGLAGADVELQCWTSGV 1435 Query: 831 HGEHLLATS-LGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSL 889 + T P +P Q + + L++ +G D G Y+C A + G Sbjct: 1436 PTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSPAGQQARDF 1493 Query: 890 FFQVRGA---W-VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT- 944 +V W + + E V L C+ GVP + W++DG L ST Sbjct: 1494 QLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEAR-GVPT-PNITWFKDGALLPTSTKVVY 1551 Query: 945 ------LRFAAITLTQAGAYHCQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP 997 L+ + AG Y C+A A G+A + + Y P + G Sbjct: 1552 TRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-----YVPPTIE-------GA 1599 Query: 998 GRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGA 1057 G ++ V P A + G + G P S + + LRLE G Sbjct: 1600 GGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGE 1659 Query: 1058 MLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQL 1117 G+Y C AS+ G+A +V VQV P V EG L +T +V P +L Sbjct: 1660 A--SSGLYSCVASSPAGEAVLQ-----YSVEVQVPPQLLVAEG-LGQVTTIVG--QPLEL 1709 Query: 1118 ----------TYTWYQDG---------QQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAP 1158 T W Q+G Q ++ + +V + + + C Sbjct: 1710 PCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTA 1769 Query: 1159 RLSRPITLDVLYAPRNLRLT-----YLLESHGGQLALVLCTVDS------RPPAQLALSH 1207 +++ +AP L + + E H A V +PP Sbjct: 1770 GAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCS 1829 Query: 1208 AGRLLASSTAASVPNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265 G L T V +L L++ RDEG Y+C+A + G++ + L+ V++ Sbjct: 1830 PGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALK-----VLV 1884 Query: 1266 APEA-------AVPEGAPITVTCADPAAHAPTLYTWYHNGR----WLQEGPAASLSFLV- 1313 P AV E A +T+ C P + +W+ + W+ G S+ V Sbjct: 1885 PPNIEPGPVNKAVLENASVTLECLASGVPPPDV-SWFKGHQPVSSWM--GVTVSVDGRVL 1941 Query: 1314 ----ATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV-IQCT 1368 A + AG+Y C A + G+ R L+V P+ + S + V + C Sbjct: 1942 RIEQAQLSDAGSYRCVASNVAGSTELR-YGLRVNVPPRITLPPSLPGPVLVNTPVRLTCN 2000 Query: 1369 VDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTA 1427 P L DG ++ + GT +QV L + A D Y C A Sbjct: 2001 ATGAPSPTLMWLKDGNPVSPA--------GTPGLQVFPGGRVLTLASARASDSGRYSCVA 2052 Query: 1428 QNLLGSISTIGRLQVEGARVVA--EPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWND 1485 + +G LQV + E + V ++ L C+ P PV +W+ + Sbjct: 2053 VSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV----LSWWKDG 2108 Query: 1486 RRLHAEPVPTL----AFTHVARAQ---AGMYHCLAELPTGAAA---SAPVMLRVLYPPKT 1535 R L P L A V RA AG Y C A G + + V + ++P + Sbjct: 2109 RPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRE 2168 Query: 1536 PTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNA 1595 + E G L C P ++ QP HV A Sbjct: 2169 SHTLTVRE---GHPTSLSCECRGVPFPKISWR------KDGQPLPGEGAGLQHVSAVGRL 2219 Query: 1596 LRVDIEALRPSDQGEYICSASNVLGSAS 1623 L + L + +G Y C SNV+G++S Sbjct: 2220 LYLGQAQL--AQEGTYTCECSNVVGNSS 2245 Score = 155 bits (391), Expect = 4e-37 Identities = 382/1680 (22%), Positives = 579/1680 (34%), Gaps = 292/1680 (17%) Query: 105 LQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELL--EGTEVDFNCST 162 +Q DSG Y+ R E D ++T P V + E+L G +V+ C T Sbjct: 1376 IQEGDSGLYSCRAENQAGTAQRDFHLLVLT---PPSVLGAGAAQEVLGLAGADVELQCWT 1432 Query: 163 PYVCLQEQVRLQW-QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSV 221 V + ++W + + P + Q E V + H+ D GR S Sbjct: 1433 SGVPTPQ---VEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG----DEGRYQCVAFSP 1485 Query: 222 ANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGV 281 A +A+ + L+V +AP + ++ LV L C+ +I W KDG Sbjct: 1486 AGQQAR-DFQLRV-HAPPTIWGSNETGEVAVMEDHLVQLLCEARGV--PTPNITWFKDGA 1541 Query: 282 RLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPA 333 L T T V L L +A SDAGVYTC+A N VG+ L +++ Sbjct: 1542 LLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAG 1600 Query: 334 G-----PILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH-------SHTLRLHLAT 381 G + + V L C L SW+ + + +++ LRL Sbjct: 1601 GRPYVVKAVAGRPVALECVARGHPSPTL--SWHHEGLPVAESNESRLETDGSVLRLESPG 1658 Query: 382 RADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF--LETQAGLVGILHCSVVSEP 439 A +G Y C + G E SV V PP V + T G L C P Sbjct: 1659 EASSGLYSCVASSPAG-EAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP 1717 Query: 440 LATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGN 499 + T+ G +G S GT+ L I +E SG + C ATN G Sbjct: 1718 VPTIQWLQNGRPAEELAGVQVAS---QGTT------LHIDHVELDHSGLFACQATNEAGT 1768 Query: 500 ATSTLDFHAN---AARLLISPAAEVVEG----QAVTLSCRS------GLSPTPDARFSWY 546 A + ++ + A +L P + G + +C G P P W Sbjct: 1769 AGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWC 1828 Query: 547 LNGALLHEGPG--------SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598 G+L E G L + D G Y C A + A L VL PP Sbjct: 1829 SPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT--NLAGESKREVALKVLVPP 1886 Query: 599 R-QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCG 657 +P + L+ A L C PP + + V Sbjct: 1887 NIEPGPVNKAVLENASV------TLECLASGVPPPDVSWFKGHQPV-------------- 1926 Query: 658 GCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATV---LAIA 714 S M VT + + + I L + G Y C ASN G ST + + V + + Sbjct: 1927 --SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG--STELRYGLRVNVPPRITLP 1982 Query: 715 PS--HTLQEGTEANLTCNVSREAAGSPA-NFSWFRNG--VLWAQGP-------LETVTLL 762 PS + T LTCN A G+P+ W ++G V A P +TL Sbjct: 1983 PSLPGPVLVNTPVRLTCN----ATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLA 2038 Query: 763 PVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSR 822 +D+ Y+C ++ G V+L V PP + + C + Sbjct: 2039 SARASDSGRYSCVAVSAVGED-RQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAM 2097 Query: 823 PLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVL 882 P +L+ + P R A+ L+V + D+G Y CEA N Sbjct: 2098 PPPVLSWWKDGR----------PLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 2147 Query: 883 GSSNTSLFFQVRGAWV------QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP 936 G S V WV + S + ++EG LSC+ GVP W +DGQP Sbjct: 2148 GHSEKHYNLNV---WVAPVFPLRESHTLTVREGHPTSLSCECR-GVP-FPKISWRKDGQP 2202 Query: 937 LQESTSATLRFAAI---------TLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYA-PR 985 L + +A+ L Q G Y C+ + G+++ L + + A PR Sbjct: 2203 LPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPR 2262 Query: 986 H-VTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVA 1044 T +++ G + L C PP + T + G P G+ L + Sbjct: 2263 EPPTQVSVVQDG---VATLECNATGKPPPTV-----------TWERDGQPVGAELGLQLQ 2308 Query: 1045 VAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVN 1104 +L +E A G Y C A N G+A + ++V V P L N Sbjct: 2309 NQGQSLHVE--RAQAAHTGRYSCVAENLAGRAERKFE-----LSVLVPPELIGDLDPLTN 2361 Query: 1105 LTCLVWTTHPAQL----------TYTWY---------QDGQQRLDAHSIPLPNVTVRDAT 1145 +T + + P L W+ +D + + +D+ Sbjct: 2362 ITAALHS--PLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSG 2419 Query: 1146 SYRCGVGPPGRAPRLSRPITLDVLYAP--RNLRLTYLLESHGGQLALVLCTVDSRPPAQL 1203 Y C A R +++VL P N L +++ GQ A ++C V P +L Sbjct: 2420 LYSCLAS--NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL 2477 Query: 1204 ALSHAGRLLASSTAASV-PNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVR 1262 GR LA A + P+ + L++ G YSC A + +G+ +L Sbjct: 2478 TWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQL-----S 2532 Query: 1263 VILAP------------EAAVPEGAPITVTCADPAAHAPTLYTWYHNG------RWLQEG 1304 V+LAP E V PI++ C A +P + TW +G R +Q Sbjct: 2533 VLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNI-TWMKDGAPFEASRNIQLL 2591 Query: 1305 PAA-SLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP---QDAVLSSFR----D 1356 P L L A + AG Y+C + G + + ++VL P +D L Sbjct: 2592 PGTHGLQILNAQKEDAGQYTCVVTNELG-EAVKNYHVEVLIPPSISKDDPLGEVGVKEVK 2650 Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416 ++ S ++C + PP + DG+ + SS + L G LQ+Q Sbjct: 2651 TKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR----------LLQIQPT 2700 Query: 1417 PAGDD-TYVCTAQNLLGS--------------ISTIGRLQV--------EGARVVAEPGL 1453 D Y+C A N+ G +G E AR Sbjct: 2701 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 2760 Query: 1454 DVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA-------EPVPTLAFTHVARAQA 1506 ++ E L C P P W+ D+ L A + L V A Sbjct: 2761 EIVENNPAYLYCDTNAIPPP----DLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENA 2816 Query: 1507 GMYHCLAELPTGAAASAPVMLRVLYPP----KTPTMMVFVEPEGGLRGILDCRVDSEPLA 1562 G Y C A G +L VL PP T ++ V L C P+ Sbjct: 2817 GRYSCKASNEVGEDWLHYELL-VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVP 2875 Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622 ++ S G P P + + + + +D Y+C A N GSA Sbjct: 2876 TI----------SWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA 2925 Score = 148 bits (374), Expect = 4e-35 Identities = 309/1299 (23%), Positives = 445/1299 (34%), Gaps = 234/1299 (18%) Query: 251 NILPGELVTLTCQVNSSYPAVSSIKWLKDG----------VRLQTKTGVLHLPQAAWSDA 300 ++L G+ V L C+ + P + WLKDG +R G L L SDA Sbjct: 3228 HVLEGQEVRLDCEADGQPPP--DVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA 3285 Query: 301 GVYTCQAENGVGS---------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNE 351 G YTC A N G LV P I + VS G + VT+VC Sbjct: 3286 GAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGEL-----VTMVCPVRGS 3340 Query: 352 APSDLRYSWYKNHVLLE-------DAHSHTLRLHLATRADTGFYFCEVQNVHG-SERSGP 403 P + SW K+ + L HTLR+ AD G + C + G ++R+ Sbjct: 3341 PP--IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFT 3398 Query: 404 VSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP 463 + V V P L PV E Q +V VV L L G L S D P Sbjct: 3399 LQVQVP-PVLEPV-----EFQNDVV------VVRGSLVELPCEARGVPLPLVSWMKDGEP 3446 Query: 464 RFSGT--SGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEV 521 S + GP+ L++ + DSG Y C A + G A ++ P Sbjct: 3447 LLSQSLEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQL------TVMEPPHIE 3497 Query: 522 VEGQAVTLSCRSGL--------SPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSY 573 GQ LS G TP +W+ +G L +S DAG Y Sbjct: 3498 DSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLY 3557 Query: 574 HCRARDGHSASGPSSPAVLTV---LYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDP 630 C A A S + + PR P F L A + +L C V+++P Sbjct: 3558 TCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGL--------APGQLVLECSVEAEP 3609 Query: 631 PARLQLLHKDRVVA-----TSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685 ++ H+D +V T P G +++ + G Sbjct: 3610 APKITW-HRDGIVLQEDAHTQFPERGRF--------------------LQLQALSTADSG 3648 Query: 686 LYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANF-SW 744 Y C A NA G STS F + + S N T + +A G PA SW Sbjct: 3649 DYSCTARNAAG--STSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSW 3706 Query: 745 FRNGV-------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPD 797 ++ V + P ++ + PV DA Y C AG+ L VL PP Sbjct: 3707 RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDL-RVLEPPA 3765 Query: 798 RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEAN 857 + L + AL C P L+ + L L G ++ +N Sbjct: 3766 IAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL-----QQGAYRL-LPSN 3819 Query: 858 SLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQA------ 911 +L L G DS + C +N +G ++ R V V P + + Q Sbjct: 3820 ALLLTAP--GPQDSAQFECVVSNEVGEAH-------RLYQVTVHVPPTIADDQTDFTVTM 3870 Query: 912 ---VVLSCQVHTGVPEGTSYRWYRDGQPL-------QESTSATLRFAAITLTQAGAYHCQ 961 VVL+C TG+P T W + G L + S S L AG Y C Sbjct: 3871 MAPVVLTCH-STGIPAPT-VSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCS 3928 Query: 962 AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGD 1021 A+ + L V +P L +++ LL C P + Sbjct: 3929 ARNSAGVAHK---HVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG 3985 Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081 VA+ + P G +L I A ED G Y+C A N+ G A Sbjct: 3986 LNVATGVSTQVLPGG--------------QLRIAHASPEDAGNYLCIAKNSAGSAMGKTR 4031 Query: 1082 FDAQAVNV--QVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS------ 1133 Q V P + EG L C + +T W +DGQ A Sbjct: 4032 LVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNIT--WDKDGQPVSGAEGKFTIQP 4089 Query: 1134 ---IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAP--------RNLRLTYLL- 1181 + + N+ +DA +Y C R R + L +L P R+LRL L Sbjct: 4090 SGELLVKNLEGQDAGTYTCTA--ENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLW 4147 Query: 1182 ---ESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGF 1238 + G + TV+ RP + G A S D G Sbjct: 4148 LRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVS-------------REDSGT 4194 Query: 1239 YSCSARSPLGQANTSLELRLEGVRVILAPEAAV---PEGAPITVTCADPAAHAPTLYTWY 1295 Y C A + +G+ + ++ V+ + P G I + C P ++ W Sbjct: 4195 YVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIH-WI 4253 Query: 1296 HNG---------RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP 1346 +G LQ G SL+ R AG Y C A++ G + + L + AP Sbjct: 4254 KDGLPLRGSHLRHQLQNG---SLTIHRTERDDAGRYQCLAENEMGV-AKKVVILVLQSAP 4309 Query: 1347 QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVAR 1406 V R+ ++C EP + G+ L S + +L G+ Sbjct: 4310 VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGS------- 4362 Query: 1407 NALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQVEG 1444 L +++V GD TY C A NLLGS + L V G Sbjct: 4363 ----LWLENVETGDAGTYDCVAHNLLGSATARAFLVVRG 4397 Score = 145 bits (365), Expect = 4e-34 Identities = 291/1244 (23%), Positives = 437/1244 (35%), Gaps = 225/1244 (18%) Query: 477 EIRDLEETDSGEYKCSATN--SLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSG 534 EI + + G Y+C+A + G A + + +L+ +P V G+ LSCR Sbjct: 482 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRV- 540 Query: 535 LSPTPDARFSWYLNGALLHEGPGS-------SLLLPAASSTDAGSYHCRARDGHSASGPS 587 L P +W + +L G SL + TD G Y C A + A+G + Sbjct: 541 LGEAP-YNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN---ANGVT 596 Query: 588 SPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSL 647 +V ++ Q + T + G + C P + + + + Sbjct: 597 RASVWLLVREAPQVSIHTSSQHFSQGVEVK----VSCSASGYPTPHISWSRESQALQED- 651 Query: 648 PSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSAT--FN 705 R+ V L+ I E+ G Y C+A+N +G + T + Sbjct: 652 -------------SRIHVDAQGTLI---IQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 695 Query: 706 GQATVLAIAPSHTLQEGTEANLTCNVSREAAG-SPANFSWFRNG---VLWAQGPLETVTL 761 +V A+ + G EA L C EA+G P W+R G +L +G Sbjct: 696 DPPSVSAVNAVVLVAVGEEAVLVC----EASGVPPPRVIWYRGGLEMILAPEGSSSGKLR 751 Query: 762 LPVART-DAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVD 820 +P A+ DA Y CR + E G S + L+V + P +L + + G AL C Sbjct: 752 IPAAQERDAGTYTCRAVNELG-DASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRAT 810 Query: 821 SRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATN 880 RP + G+ LG ++ + GR + +S L + D Y CEA N Sbjct: 811 GRPPPTVTWRRGD---GQPLGLRLGA-GRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 866 Query: 881 VLGSSNTSLFFQVRG-AWVQVS---PSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP 936 V G V G A Q++ P+ + EGQ V L C V G P + W +DG+P Sbjct: 867 VFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH-WLKDGRP 925 Query: 937 LQESTSATLRF-AAITLTQA-----GAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLT 990 L + ++R ++ L +A G Y C A + S + L V PR Sbjct: 926 LPPGSRHSIRADGSLHLDRALQEHAGRYSCVAT---NTAGSQHRDVELVVQVPPRIHPTA 982 Query: 991 TLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTL 1050 T T G L C P + + S P +V+ L Sbjct: 983 THHITNEGVPASLPCVASGVPAPTITWTKETNALTSR----------GPHYNVSKEGTLL 1032 Query: 1051 RLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVW 1110 I +D G Y+C A+NT+G F +Q + + V Sbjct: 1033 ---IAQPSAQDAGAYVCTATNTVG-------FSSQEMRLSV------------------- 1063 Query: 1111 TTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLY 1170 A Y W + G L + S+ L V V D+ Y C P A S L V Sbjct: 1064 -NRLALSKYVWEEYGL--LPSGSLRLAQVQVGDSGHYECTASNP--AGSASHRYVLGVQV 1118 Query: 1171 APRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRG 1230 P+ +L+ G+ + C + P QL+ S G +L RG Sbjct: 1119 PPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQG--------------RG 1164 Query: 1231 PQ---------PRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTC 1281 PQ D G Y C A + G +ELR V+ P E + + Sbjct: 1165 PQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELR-----VLEPPHWGADETSGLLERV 1219 Query: 1282 AD-------PAAHAPTLYTWYHNG------------RWLQEGPAASLSFLVATRAHAGAY 1322 A PA P + G L+EG SL + A +G Y Sbjct: 1220 AGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEG---SLFLASVSPADSGDY 1276 Query: 1323 SCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMA----VIQCTVDSEPPAELA 1378 CQA + G+ S R A V+Y P ++ R + MA ++C + P E+ Sbjct: 1277 ECQATNEVGSTSRR--AKLVVYVPP-SIREDGRKANVSGMAGQSLTLECDANGFPVPEIV 1333 Query: 1379 LSHDGKVLATSSGVHSLASGTGHVQVARNAL-----RLQVQDVPAGDD-TYVCTAQNLLG 1432 D +++ G G QV + L L + GD Y C A+N G Sbjct: 1334 WLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG 1393 Query: 1433 SISTIGRL------QVEGARVVAEP-GLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWND 1485 + L V GA E GL GA + L C G P P W Sbjct: 1394 TAQRDFHLLVLTPPSVLGAGAAQEVLGL---AGADVELQCWTSGVPTPQVE------WTK 1444 Query: 1486 RRLHAEP------------VPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPP 1533 R P V + +HV G Y C+A P G A LRV PP Sbjct: 1445 DRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSPAGQQAR-DFQLRVHAPP 1501 Query: 1534 KTPTMMVFVEPEGGLRGILD-------CRVDSEPLASLTLHLGSRLVASSQPQGAPAEPH 1586 ++ E G +++ C P ++T L+ +S Sbjct: 1502 T-----IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTK-------- 1548 Query: 1587 IHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGV 1630 V+ + ++ + + SD G Y C ASN +G+A +T V Sbjct: 1549 --VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 1590 Score = 144 bits (362), Expect = 1e-33 Identities = 356/1523 (23%), Positives = 529/1523 (34%), Gaps = 293/1523 (19%) Query: 250 RNILPGELVTLTCQVNSSYPAVSSIKWLK--------DGVRLQTKTGVLHLPQAAWSDAG 301 R I+ L C N+ P + W + D V + VL +P +AG Sbjct: 2760 REIVENNPAYLYCDTNAIPPP--DLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAG 2817 Query: 302 VYTCQAENGVGS--------LVSPPISL---HIFMAEVQVSPAGPILENQTVTLVCNT-P 349 Y+C+A N VG +++PP+ L + EV V+ + TV+L C Sbjct: 2818 RYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS------TVSLQCPALG 2871 Query: 350 NEAPSDLRYSWYKNHV---------LLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSER 400 N P+ SW +N + +LED L++ A AD Y C +N GS Sbjct: 2872 NPVPT---ISWLQNGLPFSPSPRLQVLEDGQ--VLQVSTAEVADAASYMCVAENQAGSAE 2926 Query: 401 SGPVSVVVNHPPLTPVL-----TAFLETQAGLVGILHCSVVSEPL---ATLVLSHGGHIL 452 ++ V PP L TA L + L +H E + LS G + Sbjct: 2927 K-LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVF 2985 Query: 453 ASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR 512 P + L++ +DSG Y C A N+ G + Sbjct: 2986 LL----------------PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLS----- 3024 Query: 513 LLISPAAE-----------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP----- 556 +L+ PA V G LSC + P P +WY +G L Sbjct: 3025 VLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTV--TWYKDGQPLVLAQRTQAL 3082 Query: 557 --GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGA 614 G L + A +D G Y C+ + A LTV PP T AG+ Sbjct: 3083 RGGQRLEIQEAQVSDKGLYSCKV--SNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGS 3140 Query: 615 GAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRV 674 +L C V P + L KDR+ S G S G R+ Sbjct: 3141 PL----VLTCDVSGVPAPTVTWL-KDRMPVESSAVHGVVSRGG---------------RL 3180 Query: 675 EIHNPLLEEEGLYLCEASNALGNAS----TSATFNGQATVLAIAPSHTLQEGTEANLTCN 730 ++ + G Y C A N A + + +A H + EG E L C Sbjct: 3181 QLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC- 3239 Query: 731 VSREAAGSPA-NFSWFRNGVLWAQ--GPL-------ETVTLLPVARTDAALYACRILTEA 780 EA G P + +W ++G Q GP ++ L + +DA Y C A Sbjct: 3240 ---EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPA 3296 Query: 781 G--AQLSTPVLLSVLYPPDRPKL---SALLDMGQGHMALFICTV-DSRPLALLALFHGEH 834 G A+L T ++VL PP + S L G + +C V S P+ + L G Sbjct: 3297 GEDARLHT---VNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDG-- 3351 Query: 835 LLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894 L L + HG + L + ++ L D+G + C A + G ++ + QV Sbjct: 3352 -LPLPLSQRTLLHG--------SGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV- 3401 Query: 895 GAWVQVSPSPELQE---------GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST---S 942 QV P E E G V L C+ GVP W +DG+PL + Sbjct: 3402 ----QVPPVLEPVEFQNDVVVVRGSLVELPCEAR-GVPLPL-VSWMKDGEPLLSQSLEQG 3455 Query: 943 ATLRFAAITLTQAGAYHCQA-----QAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP 997 +L+ A+ +G Y C A +A ++ P + S P ++LT P Sbjct: 3456 PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLT------P 3509 Query: 998 GRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGA 1057 G LLC P + H D + L+ + + A LR+ Sbjct: 3510 GAPMELLCDAQGTPQPNITW-HKDGQALTRLE------------NNSRATRVLRVR---- 3552 Query: 1058 MLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGAT-----VREGQLVNLTCLVWTT 1112 D G+Y C A + G S QA V P + GQLV L C V Sbjct: 3553 ---DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSV-EA 3607 Query: 1113 HPAQLTYTWYQDG-QQRLDAHS--------IPLPNVTVRDATSYRC----GVGPPGRAPR 1159 PA TW++DG + DAH+ + L ++ D+ Y C G A R Sbjct: 3608 EPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 3666 Query: 1160 LSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGR--LLASSTA 1217 + + P + ++ Q AL+ C D PA L R L S Sbjct: 3667 VEIHTVPTIRSGPPAVNVSV------NQTALLPCQADG-VPAPLVSWRKDRVPLDPRSPR 3719 Query: 1218 ASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPI 1277 + L ++ +D G Y C A + G +LR +L P A P + + Sbjct: 3720 FEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR------VLEPPAIAPSPSNL 3773 Query: 1278 TVTCADPA-------AHAPTLYTWYHNGRWL----QEG-----PAASLSFLVATRAHAGA 1321 T+T PA L W+ +G+ L Q+G P+ +L + Sbjct: 3774 TLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQ 3833 Query: 1322 YSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMA--VIQCTVDSEPPAELAL 1379 + C + G QV + D MA V+ C P ++ Sbjct: 3834 FECVVSNEVGEAHR---LYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSW 3890 Query: 1380 SHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGR 1439 S G L A G+G+ AL + Q +P Y C+A+N G Sbjct: 3891 SKAGAQLG--------ARGSGYRVSPSGALEIG-QALPIHAGRYTCSARNSAGVAHKHVF 3941 Query: 1440 LQVEGARVVAEPGLDVPEGAA---LNLSCRLLGGPGPVGNSTFAWFWNDRRL------HA 1490 L V+ + VV +P V A + L C G P P T W + Sbjct: 3942 LTVQASPVV-KPLPSVVRAVAEEEVLLPCEASGIPRP----TITWQKEGLNVATGVSTQV 3996 Query: 1491 EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRG 1550 P L H + AG Y C+A+ G+A L V PP + + G Sbjct: 3997 LPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGK-TRLVVQVPPVIENGLPDLSTTEGSHA 4055 Query: 1551 ILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGE 1610 L C+ P ++T + V+ AE + S L ++ L D G Sbjct: 4056 FLPCKARGSPEPNITWDKDGQPVSG-------AEGKFTIQPSGELL---VKNLEGQDAGT 4105 Query: 1611 YICSASNVLGSASTSTYFGVRAL 1633 Y C+A N +G A + + L Sbjct: 4106 YTCTAENAVGRARRRVHLTILVL 4128 Score = 140 bits (353), Expect = 1e-32 Identities = 212/859 (24%), Positives = 310/859 (36%), Gaps = 135/859 (15%) Query: 855 EANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPE--LQEGQAV 912 E+ + E+ + G+Y C A + G+ V Q+ P+P + G+ Sbjct: 475 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETA 534 Query: 913 VLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITL-------TQAGAYHCQAQAP 965 VLSC+V P + W RD + L ST + A ++L T G Y C A Sbjct: 535 VLSCRVLGEAPYNLT--WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA 592 Query: 966 GSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVA 1025 T A + L V AP+ T+ G + C P + + + Sbjct: 593 NGVT---RASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ 649 Query: 1026 STLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF--- 1082 R+HV L I G ED G Y C+A+N +G + Sbjct: 650 -----------EDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 695 Query: 1083 ---DAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL------DAHS 1133 AVN V V G+ L C P ++ WY+ G + + + Sbjct: 696 DPPSVSAVNAVV----LVAVGEEAVLVCEASGVPPPRV--IWYRGGLEMILAPEGSSSGK 749 Query: 1134 IPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVL 1192 + +P RDA +Y C V G A S I L V +AP+ L + G+ AL+ Sbjct: 750 LRIPAAQERDAGTYTCRAVNELGDA---SAEIQLAVGHAPQLTELPRDVTVELGRSALLA 806 Query: 1193 CTVDSRPPAQLALSHAG------RLLASSTAAS-VPNTLRLELRGPQPRDEGFYSCSARS 1245 C RPP + RL A + S P++ L P D+ Y C AR+ Sbjct: 807 CRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 866 Query: 1246 PLGQANTSLELRLEGVR----VILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWL 1301 G+ L + G AP V EG P+++ C A W +GR L Sbjct: 867 VFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPL 926 Query: 1302 QEGPA------ASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR 1355 G SL A + HAG YSC A + G++ R L V P+ ++ Sbjct: 927 PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQ-HRDVELVVQVPPRIHPTATHH 985 Query: 1356 DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR----- 1410 + A + C P + + + L TS G H S G + +A+ + + Sbjct: 986 ITNEGVPASLPCVASGVPAPTITWTKETNAL-TSRGPHYNVSKEGTLLIAQPSAQDAGAY 1044 Query: 1411 ---------------------------------------LQVQDVPAGDD-TYVCTAQNL 1430 L++ V GD Y CTA N Sbjct: 1045 VCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNP 1104 Query: 1431 LGSISTIGRLQVEGARVVAEPG---LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRR 1487 GS S L V+ V +PG L V G AL+L+C G P P +W + Sbjct: 1105 AGSASHRYVLGVQVPPQV-QPGPRVLKVLVGEALDLNCVAEGNPEP----QLSWSKDGVV 1159 Query: 1488 LHAE-PVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPK--TPTMMVFVEP 1544 L P ++ F + + AG Y C A G A V LRVL PP +E Sbjct: 1160 LQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVDA-WEVELRVLEPPHWGADETSGLLER 1218 Query: 1545 EGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALR 1604 G L C P +T G SS+P +P + VL + + ++ Sbjct: 1219 VAGENASLPCPARGTPKPQVTWRKG----PSSEP--LHGQPGVAVLEEGSLF---LASVS 1269 Query: 1605 PSDQGEYICSASNVLGSAS 1623 P+D G+Y C A+N +GS S Sbjct: 1270 PADSGDYECQATNEVGSTS 1288 Score = 130 bits (327), Expect = 1e-29 Identities = 316/1405 (22%), Positives = 475/1405 (33%), Gaps = 267/1405 (19%) Query: 380 ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEP 439 A++A+ G Y C + G+ R+ +VV PP V + G +L C V+ E Sbjct: 486 ASKAEEGTYECTAVSRAGTGRA-KAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA 544 Query: 440 LATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG- 498 L +L +++G + L LEI + TD G Y+C A+N+ G Sbjct: 545 PYNLTWVRDWRVLPASTG---------RVAQLADLSLEISGIIPTDGGRYQCVASNANGV 595 Query: 499 NATSTLDFHANAARLLISPAAE-VVEGQAVTLSCRSGLSPTPDARFSWYLNGALL----- 552 S A ++ I +++ +G V +SC + PTP SW L Sbjct: 596 TRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTP--HISWSRESQALQEDSR 653 Query: 553 -HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDA 611 H +L++ + DAG+Y C+A + G V P + + L A Sbjct: 654 IHVDAQGTLIIQGVAPEDAGNYSCQAT---NEVGTDQETVTLYYTDPPSVSAVNAVVLVA 710 Query: 612 AGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNL 671 G A +L+C PP R+ + ++ + P G S ++++ A Sbjct: 711 VGEEA----VLVCEASGVPPPRV-IWYRGGLEMILAPEGSS-------SGKLRIPAAQE- 757 Query: 672 LRVEIHNPLLEEEGLYLCEASNALGNASTSATFN-GQATVLAIAPSH-TLQEGTEANLTC 729 + G Y C A N LG+AS G A L P T++ G A L C Sbjct: 758 ----------RDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLAC 807 Query: 730 NVSREAAGSPANFSWFR-------------NGVLWAQGPLETVTLLPVARTDAALYACRI 776 R P +W R G Q + VA D A Y C Sbjct: 808 ---RATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEA 864 Query: 777 LTEAG-AQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTV-DSRPLALLALFHGEH 834 G Q ++++ PP + + + +G C V RPL H Sbjct: 865 RNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLP------ERH 918 Query: 835 LLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSS--NTSLFFQ 892 L G +P R +A+ + L + +G Y C ATN GS + L Q Sbjct: 919 WLKD--GRPLPPGSRHSIRADGS---LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ 973 Query: 893 VRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRD-------GQPLQESTSATL 945 V + EG L C V +GVP T W ++ G S TL Sbjct: 974 VPPRIHPTATHHITNEGVPASLPC-VASGVPAPT-ITWTKETNALTSRGPHYNVSKEGTL 1031 Query: 946 RFAAITLTQAGAYHCQA--------QAPGSATTSLAAPISLHVSYA-------------- 983 A + AGAY C A Q + LA + Y Sbjct: 1032 LIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQV 1091 Query: 984 --PRHVTLTTLMDTGPGR----LGLLLCRVDSDPPAQLRLLHGDRL-VASTLQGVGGPEG 1036 H T G LG+ + P L++L G+ L + +G P+ Sbjct: 1092 GDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQL 1151 Query: 1037 SSPRLHVAVAPNTLRLEIHGAML--EDEGVYICEASNTLGQASASADFDAQAVNVQV--- 1091 S + V + + +H A + D G Y CEASN SA DA V ++V Sbjct: 1152 SWSKDGVVLQGRGPQGSVHFAAIRTSDAGRYRCEASN-------SAGVDAWEVELRVLEP 1204 Query: 1092 --WPGATVREGQL-------VNLTCLVWTTHPAQLTY--------TWYQDGQQRLDAHSI 1134 W GA G L +L C T Q+T+ Q G L+ S+ Sbjct: 1205 PHW-GADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSL 1263 Query: 1135 PLPNVTVRDATSYRC----GVGPPGRAPRLSRPITLDVLYAPRNLR---LTYLLESHGGQ 1187 L +V+ D+ Y C VG R +L V+Y P ++R + GQ Sbjct: 1264 FLASVSPADSGDYECQATNEVGSTSRRAKL-------VVYVPPSIREDGRKANVSGMAGQ 1316 Query: 1188 LALVLCTVDSRPPAQLA-----------LSHAG-------------RLLASSTAASVPNT 1223 + C + P ++ L AG RLL + P Sbjct: 1317 SLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRI 1376 Query: 1224 LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVP----EGAPITV 1279 Q D G YSC A + G A L + +L AA GA + + Sbjct: 1377 --------QEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVEL 1428 Query: 1280 TCADPAAHAPTLYTWYHNGRWLQEGPAASL----SFLVATRAHA---GAYSCQAQDAQGT 1332 C P + L GP + L T +H G Y C A G Sbjct: 1429 QCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAG- 1487 Query: 1333 RSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQ-------CTVDSEPPAELALSHDGKV 1385 + +R L+V P + + + +AV++ C P + DG + Sbjct: 1488 QQARDFQLRVHAPP-----TIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGAL 1542 Query: 1386 LATSSGVHSLASGTGHVQVARNALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQVEG 1444 L TS+ V R +LQ+ + D Y C A N +G+ RL V Sbjct: 1543 LPTST----------KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV 1592 Query: 1445 ARVVAEPG-----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFW--------NDRRLHAE 1491 + G + G + L C G P P T +W N+ RL + Sbjct: 1593 PPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP----TLSWHHEGLPVAESNESRLETD 1648 Query: 1492 PVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI 1551 L A +G+Y C+A P G A +L+ + P ++ E G + I Sbjct: 1649 G-SVLRLESPGEASSGLYSCVASSPAGEA-----VLQYSVEVQVPPQLLVAEGLGQVTTI 1702 Query: 1552 ------LDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRP 1605 L C+ P+ ++ G PAE V + + I+ + Sbjct: 1703 VGQPLELPCQASGSPVPTI----------QWLQNGRPAEELAGVQVASQGTTLHIDHVEL 1752 Query: 1606 SDQGEYICSASNVLGSASTSTYFGV 1630 G + C A+N G+A V Sbjct: 1753 DHSGLFACQATNEAGTAGAEVEVSV 1777 Score = 124 bits (311), Expect = 8e-28 Identities = 263/1141 (23%), Positives = 402/1141 (35%), Gaps = 168/1141 (14%) Query: 188 SQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSP 247 SQ+ G GH TL ++ I C + A LQV+ P +L Sbjct: 3357 SQRTLLHGSGH--TLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPP----VLEPV 3410 Query: 248 SGRN---ILPGELVTLTCQVNS-SYPAVSSIKWLKDGVRLQTKT----GVLHLPQAAWSD 299 +N ++ G LV L C+ P VS W+KDG L +++ L L D Sbjct: 3411 EFQNDVVVVRGSLVELPCEARGVPLPLVS---WMKDGEPLLSQSLEQGPSLQLEAVGAGD 3467 Query: 300 AGVYTCQAENGVG--------SLVSPPISLHIFMA----EVQVSPAGPILENQTVTLVCN 347 +G Y+C A + G +++ PP HI + E+ ++P P+ L+C+ Sbjct: 3468 SGTYSCVAVSEAGEARRHFQLTVMEPP---HIEDSGQPTELSLTPGAPM------ELLCD 3518 Query: 348 TPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGS-ERSGPVSV 406 ++ +W+K+ L +++ + D G Y C ++ G+ E+S V V Sbjct: 3519 AQGTPQPNI--TWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRV 3576 Query: 407 VVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466 + P F+ A +L CSV +EP + G +L + Sbjct: 3577 QAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAH--------- 3627 Query: 467 GTSGPNSLR-LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLIS--PAAEVVE 523 T P R L+++ L DSG+Y C+A N+ G+ + + + S PA V Sbjct: 3628 -TQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSV 3686 Query: 524 GQAVTLSCRSGLSPTPDARFSWYLNGALLHEG-------PGSSLLLPAASSTDAGSYHCR 576 Q L C++ P P SW + L P SL + + DAG Y C Sbjct: 3687 NQTALLPCQADGVPAP--LVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCL 3744 Query: 577 ARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQL 636 A +SA L VL PP + L L A LL C P + Sbjct: 3745 A--SNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPA-----LLPCEASGSPKPLVVW 3797 Query: 637 LHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG 696 + + L G ++ + LL + P ++ + C SN +G Sbjct: 3798 WKDGQKLDFRLQQGA-----------YRLLPSNALL---LTAPGPQDSAQFECVVSNEVG 3843 Query: 697 NAST--SATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNGV---- 749 A T + T+ T+ LTC+ + G PA SW + G Sbjct: 3844 EAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCH----STGIPAPTVSWSKAGAQLGA 3899 Query: 750 ------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSA 803 + G LE LP+ A Y C AG V L+V P L + Sbjct: 3900 RGSGYRVSPSGALEIGQALPI---HAGRYTCSARNSAGVA-HKHVFLTVQASPVVKPLPS 3955 Query: 804 LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863 ++ L C P + +AT + QV G+ L + Sbjct: 3956 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ-----------LRI 4004 Query: 864 RELGLGDSGSYRCEATNVLGSS--NTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTG 921 D+G+Y C A N GS+ T L QV P EG L C+ G Sbjct: 4005 AHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKAR-G 4063 Query: 922 VPEGTSYRWYRDGQPLQEST-------SATLRFAAITLTQAGAYHCQAQAPGSATTSLAA 974 PE + W +DGQP+ + S L + AG Y C A+ +A Sbjct: 4064 SPE-PNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAE---NAVGRARR 4119 Query: 975 PISLHVSYAPRHVTLTTLMDTGPGRLG---LLLCRVDSDPPAQLRLLHGDRLVASTLQGV 1031 + L + P TTL RLG L C P ++ DR V +GV Sbjct: 4120 RVHLTILVLP---VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT---EGV 4173 Query: 1032 GGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF---DAQAVN 1088 +G S AV+ ED G Y+C A N +G+ A + +A + Sbjct: 4174 SEQDGGSTLQRAAVSR------------EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQ 4221 Query: 1089 VQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDG--------QQRLDAHSIPLPNVT 1140 + + G + L C+V + W +DG + +L S+ + Sbjct: 4222 GEAFSYLVEPVGGSIQLDCVVRGDPVPDIH--WIKDGLPLRGSHLRHQLQNGSLTIHRTE 4279 Query: 1141 VRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRP 1199 DA Y+C G A ++ + L + AP + G + C P Sbjct: 4280 RDDAGRYQCLAENEMGVAKKV---VILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEP 4336 Query: 1200 PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE 1259 + AG+ L +S L L + D G Y C A + LG A L + Sbjct: 4337 TPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 4396 Query: 1260 G 1260 G Sbjct: 4397 G 4397 Score = 108 bits (271), Expect = 3e-23 Identities = 163/663 (24%), Positives = 244/663 (36%), Gaps = 72/663 (10%) Query: 1002 LLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061 L+ C V S P +L+L G+ + H + N+ EI A + Sbjct: 445 LVSCSVHSALPFRLQLRRGEARLGE-------------ERHFQESGNS-SWEILRASKAE 490 Query: 1062 EGVYICEASNTLGQASASADFDAQAVNVQVWPG--ATVREGQLVNLTCLVWTTHPAQLTY 1119 EG Y C A + G A A Q+ P TV G+ L+C V P LT Sbjct: 491 EGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT- 549 Query: 1120 TWYQDGQ---------QRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLY 1170 W +D + +L S+ + + D Y+C R S + L V Sbjct: 550 -WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS--VWLLVRE 606 Query: 1171 APRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRG 1230 AP+ T G V C+ P ++ S + L + V L ++G Sbjct: 607 APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQG 666 Query: 1231 PQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAA--VPEGAPITVTCADPAAHA 1288 P D G YSC A + +G ++ L + A A V G + C + + Sbjct: 667 VAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC-EASGVP 725 Query: 1289 PTLYTWYHNGRWLQEGPAAS----LSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLY 1344 P WY G + P S L A AG Y+C+A + G S+ L V + Sbjct: 726 PPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE-IQLAVGH 784 Query: 1345 APQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSH-DGKVLATSSGVHSLASGTGHVQ 1403 APQ L A++ C PP + DG+ L L +G G Sbjct: 785 APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL-----RLGAGRGSRS 839 Query: 1404 VARNALRLQVQDV-PAGDDTYVCTAQNLLGSISTIGRLQVEGAR----VVAEPGLDVPEG 1458 ++ L + V P YVC A+N+ G + RL V G + P + V EG Sbjct: 840 RQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEG 899 Query: 1459 AALNLSCRLLGG-PGPVGNSTFAWFWNDRRL---HAEPVPTLAFTHVARA---QAGMYHC 1511 ++L C +L G P P + W + R L + H+ RA AG Y C Sbjct: 900 QPVSLPCIVLAGRPLPERH----WLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSC 955 Query: 1512 LAELPTGAAASAPVMLRVLYPPKT-PTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGS 1570 +A T + V L V PP+ PT + E G+ L C P ++T + Sbjct: 956 VA-TNTAGSQHRDVELVVQVPPRIHPTATHHITNE-GVPASLPCVASGVPAPTITWTKET 1013 Query: 1571 RLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGV 1630 + S P ++ ++A P+A D G Y+C+A+N +G +S V Sbjct: 1014 NALTSRGPHYNVSKEGTLLIAQPSA----------QDAGAYVCTATNTVGFSSQEMRLSV 1063 Query: 1631 RAL 1633 L Sbjct: 1064 NRL 1066 Score = 83.6 bits (205), Expect = 2e-15 Identities = 116/457 (25%), Positives = 168/457 (36%), Gaps = 52/457 (11%) Query: 1187 QLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSA--R 1244 Q LV C+V S P +L L L E+ +EG Y C+A R Sbjct: 442 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSR 501 Query: 1245 SPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWL--Q 1302 + G+A + + +++ AP V G ++C AP TW + R L Sbjct: 502 AGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR-VLGEAPYNLTWVRDWRVLPAS 560 Query: 1303 EGPAASLSFLV-----ATRAHAGAYSCQAQDAQG-TRSSRPAALQVLYAPQDAVLSSFRD 1356 G A L+ L G Y C A +A G TR+S L V APQ ++ +S + Sbjct: 561 TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS--VWLLVREAPQVSIHTSSQH 618 Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416 + C+ P ++ S + + L S +H A GT L +Q V Sbjct: 619 FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT-----------LIIQGV 667 Query: 1417 -PAGDDTYVCTAQNLLGS-ISTIGRLQVEGARVVAEPGLD-VPEGAALNLSCRLLGGPGP 1473 P Y C A N +G+ T+ + V A + V G L C G P P Sbjct: 668 APEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPP 727 Query: 1474 VGNSTFAWFWNDRRLHAEPVPT----LAFTHVARAQAGMYHCLAELPTGAAASAPVMLRV 1529 W+ + P + L AG Y C A G ASA + L V Sbjct: 728 ----RVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELG-DASAEIQLAV 782 Query: 1530 LYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLH------LGSRLVASSQPQGAPA 1583 + P+ + V E G +L CR P ++T LG RL A + Sbjct: 783 GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRS--- 839 Query: 1584 EPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620 P++ + E++ P DQ Y+C A NV G Sbjct: 840 -------RQPDSGVLFFESVAPEDQAPYVCEARNVFG 869 Score = 75.1 bits (183), Expect = 5e-13 Identities = 173/795 (21%), Positives = 273/795 (34%), Gaps = 129/795 (16%) Query: 910 QAVVLSCQVHTGVPEGTSYR----WYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAP 965 Q +++SC VH+ +P R + + QES +++ + + G Y C A Sbjct: 442 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAV-- 499 Query: 966 GSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVA 1025 S + A + V+ P + + PG +L CRV + P L + R++ Sbjct: 500 -SRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL- 557 Query: 1026 STLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF--- 1082 P + +A L LEI G + D G Y C ASN G AS Sbjct: 558 --------PASTGRVAQLA----DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR 605 Query: 1083 DAQAVNVQVWPGATVREGQLVNLTC---------LVWTTHPAQLTYTWYQDGQQRLDAH- 1132 +A V++ +G V ++C + W+ L +D + +DA Sbjct: 606 EAPQVSIHT-SSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL----QEDSRIHVDAQG 660 Query: 1133 SIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVL 1192 ++ + V DA +Y C +TL P + ++ G+ A+++ Sbjct: 661 TLIIQGVAPEDAGNYSCQA--TNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 718 Query: 1193 CTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANT 1252 C PP ++ G + + S LR+ Q RD G Y+C A + LG A+ Sbjct: 719 CEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIP--AAQERDAGTYTCRAVNELGDASA 776 Query: 1253 SLELRLEGVRVI--LAPEAAVPEGAPITVTCADPAAHAPTLYTWYH-------------N 1297 ++L + + L + V G + C PT+ TW Sbjct: 777 EIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTV-TWRRGDGQPLGLRLGAGR 835 Query: 1298 GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLS--SFR 1355 G ++ + L F Y C+A++ G + + +AP S + R Sbjct: 836 GSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVR 895 Query: 1356 DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQD 1415 + +++ + P E DG+ L S A G+ H+ A LQ Sbjct: 896 VLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRA-----LQEH- 949 Query: 1416 VPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLD--VPEGAALNLSCRLLGGPGP 1473 AG Y C A N GS L V+ + EG +L C G P P Sbjct: 950 --AG--RYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP 1005 Query: 1474 VGNSTFAWFWNDRRL-------HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVM 1526 T W L + TL + AG Y C A G ++ Sbjct: 1006 ----TITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQE--- 1058 Query: 1527 LRVLYPPKTPTMMVFVE----PEGGLR---------GILDCRVDSEPLAS---------- 1563 +R+ + V+ E P G LR G +C S P S Sbjct: 1059 MRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTA-SNPAGSASHRYVLGVQ 1117 Query: 1564 -----------LTLHLGSRLVASSQPQGAPAEPHIHVLASPNALR-------VDIEALRP 1605 L + +G L + +G P EP + L+ V A+R Sbjct: 1118 VPPQVQPGPRVLKVLVGEALDLNCVAEGNP-EPQLSWSKDGVVLQGRGPQGSVHFAAIRT 1176 Query: 1606 SDQGEYICSASNVLG 1620 SD G Y C ASN G Sbjct: 1177 SDAGRYRCEASNSAG 1191 Score = 66.2 bits (160), Expect = 3e-10 Identities = 118/490 (24%), Positives = 177/490 (36%), Gaps = 79/490 (16%) Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT-LRLELRGPQPRDEGFYSCSAR 1244 G+ A++ C V P L R+L +ST L LE+ G P D G Y C A Sbjct: 531 GETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVAS 590 Query: 1245 SPLGQANTSLELRLEGVRVILAPEAAV-------PEGAPITVTCADPAAHAPTLYTWYHN 1297 + G S+ L + AP+ ++ +G + V+C+ P + +W Sbjct: 591 NANGVTRASVWLLVRE-----APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI-SWSRE 644 Query: 1298 GRWLQEGPA------ASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVL 1351 + LQE +L AG YSCQA + GT L P + + Sbjct: 645 SQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGT-DQETVTLYYTDPPSVSAV 703 Query: 1352 SSFRDSRARSMAVIQCTVDSEPPAELALSHDG-KVLATSSGVHSLASGTGHVQVARNALR 1410 ++ AV+ C PP + G +++ G S +G +++ Sbjct: 704 NAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG-----SSSGKLRIPA---- 754 Query: 1411 LQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPE--GAALNLSCRLL 1468 Q+ AG TY C A N LG S +L V A + E DV G + L+CR Sbjct: 755 --AQERDAG--TYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRAT 810 Query: 1469 GGPGPVGNSTFAWFWND-------------RRLHAEPVPTLAFTHVARAQAGMYHCLAEL 1515 G P P T W D R L F VA Y C A Sbjct: 811 GRPPP----TVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 866 Query: 1516 PTGAA-ASAPVMLRVLYPPK----TPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGS 1570 G A A +++ PP+ PT+ V ++ +P++ + L Sbjct: 867 VFGKVQAEARLIVTGHAPPQIASSAPTVRV---------------LEGQPVSLPCIVLAG 911 Query: 1571 RLVASSQ--PQGAPAEPHI-HVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTY 1627 R + G P P H + + +L +D AL+ G Y C A+N GS Sbjct: 912 RPLPERHWLKDGRPLPPGSRHSIRADGSLHLD-RALQ-EHAGRYSCVATNTAGSQHRDVE 969 Query: 1628 FGVRALHRLH 1637 V+ R+H Sbjct: 970 LVVQVPPRIH 979 Score = 47.4 bits (111), Expect = 1e-04 Identities = 82/328 (25%), Positives = 119/328 (36%), Gaps = 37/328 (11%) Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159 LL+K+L+ +D+G+Y E + V T++ + P T+ L G + Sbjct: 4093 LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL---PVFTTLPGDRSLRLGDRLWLR 4149 Query: 160 CSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQL 219 C+ R+ W D R VT E G L+ A+S +D G + C Sbjct: 4150 CAARG---SPTPRIGWTVND--RPVTEGVS--EQDGGSTLQ--RAAVSREDSGTYV-CWA 4199 Query: 220 SVANHRAQSEIHLQVKYAP----KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIK 275 R Q+ + VK AP + L+ P G +I L C V V I Sbjct: 4200 ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSI------QLDCVVRGD--PVPDIH 4251 Query: 276 WLKDGVRL-------QTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEV 328 W+KDG+ L Q + G L + + DAG Y C AEN +G I + Sbjct: 4252 WIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVF 4311 Query: 329 QVSPAG-PILENQTVTLVCNTPNEAPSDLRYSWYKNHVL----LEDAHSHTLRLHLATRA 383 QV P + V L C E + + + L +L L Sbjct: 4312 QVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETG 4371 Query: 384 DTGFYFCEVQNVHGSERSGPVSVVVNHP 411 D G Y C N+ GS + VV P Sbjct: 4372 DAGTYDCVAHNLLGSATARAFLVVRGEP 4399 >gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] Length = 3783 Score = 205 bits (522), Expect = 3e-52 Identities = 356/1491 (23%), Positives = 543/1491 (36%), Gaps = 255/1491 (17%) Query: 259 TLTCQVNSSYPAVSSIKWLKDGV------RLQTKTG--VLHLPQAAWSDAGVYTCQAENG 310 T++ Q + V +I WL++G+ RLQ VL + A +DA Y C AEN Sbjct: 1580 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ 1639 Query: 311 VGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLR------YSWYKNH 364 GS +F VQV P L+ + VT + N+ P D+ +WYK+ Sbjct: 1640 AGSAEK------LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDS 1693 Query: 365 VLLEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSERS-GPVSVVV----NHPP 412 L +HTL+L A +D+G Y CE N G ++ +SV+V P Sbjct: 1694 QALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAP 1753 Query: 413 LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPN 472 P + + G +L C + P T+ G L R G Sbjct: 1754 RGPQDAVLV--RVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQ-------RTQALRGGQ 1804 Query: 473 SLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE---GQAVTL 529 RLEI++ + +D G Y C +N G A T +P E V G + L Sbjct: 1805 --RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVL 1862 Query: 530 SCRSGLSPTPDARFSWY-----LNGALLH--EGPGSSLLLPAASSTDAGSYHCRARDGHS 582 +C +S P +W + + +H G L L AG+Y C A + + Sbjct: 1863 TC--DVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA 1920 Query: 583 ASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRV 642 + V+ VL PR + + G+ L C D PP + L Sbjct: 1921 EA--RKDFVVAVLVAPRIRSSGVAREHHVL---EGQEVRLDCEADGQPPPDVAWLKDGSP 1975 Query: 643 VATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSA 702 + + GG S +K +A + G Y C A N G + Sbjct: 1976 LGQDMGPHLRFYLDGG-SLVLKGLRA-------------SDAGAYTCVAHNPAGEDARLH 2021 Query: 703 TFNGQATVLAIAPSHTLQEGTEAN---------LTCNVSREAAGSPANFSWFRNGV---- 749 T N + + P T+++G + + L V P + SW ++G+ Sbjct: 2022 TVN-----VLVPP--TIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL 2074 Query: 750 ---LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLD 806 G T+ + V DA ++ C + AG L V PP + D Sbjct: 2075 SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGV-ADRNFTLQVQVPPVLEPVEFQND 2133 Query: 807 --MGQGHMALFICTVDSRPLALLA-LFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863 + +G + C PL L++ + GE LL+ SL Q PS L++ Sbjct: 2134 VVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSL-EQGPS--------------LQL 2178 Query: 864 RELGLGDSGSYRCEATNVLGSSNTSLFFQV-RGAWVQVSPSP---ELQEGQAVVLSCQVH 919 +G GDSG+Y C A + G + V ++ S P L G + L C Sbjct: 2179 EAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 2238 Query: 920 TGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSA-----TTSLAA 974 G P+ + W++DGQ L + + + + AG Y C A++P A + A Sbjct: 2239 -GTPQ-PNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQA 2296 Query: 975 PISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034 P ++ PR V + PG+L +L C V+++P ++ H D +V Sbjct: 2297 PPNIVGPRGPRFV-----VGLAPGQL-VLECSVEAEPAPKI-TWHRDGIVL--------- 2340 Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG 1094 H L++ D G Y C A N G S A V++ Sbjct: 2341 ---QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSV-------AFRVEIHTV 2390 Query: 1095 ATVREGQ-----LVNLTCLVWTTH---PAQLTYTWYQDGQ---------QRLDAHSIPLP 1137 T+R G VN T L+ PA L +W +D + L S+ + Sbjct: 2391 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLV-SWRKDRVPLDPRSPRFEILPEGSLRIQ 2449 Query: 1138 NVTVRDATSYRC------GVGPPGRAPRLSRPITLDVLYAPRNLRLT------YLLESHG 1185 V +DA Y C G GR R+ P + +P NL LT E+ G Sbjct: 2450 PVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPA--IAPSPSNLTLTAHTPALLPCEASG 2507 Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARS 1245 LV+ D + A RLL S+ L L P P+D + C + Sbjct: 2508 SPKPLVVWWKDGQKLDFRLQQGAYRLLPSNA---------LLLTAPGPQDSAQFECVVSN 2558 Query: 1246 PLGQANTSLELRLEGVRVILAPEAA-------VPEGAPITVTCADPAAHAPTLYTWYHNG 1298 +G+A+ RL V V + P A V AP+ +TC APT+ +W G Sbjct: 2559 EVGEAH-----RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTV-SWSKAG 2612 Query: 1299 RWL-------QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVL 1351 L + P+ +L A HAG Y+C A+++ G + + L V +P L Sbjct: 2613 AQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPL 2671 Query: 1352 SSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRL 1411 S + A ++ C P + +G +AT GV + G +++A + Sbjct: 2672 PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVAT--GVSTQVLPGGQLRIAHAS--- 2726 Query: 1412 QVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAE--PGLDVPEGAALNLSCRLLG 1469 P Y+C A+N GS RL V+ V+ P L EG+ L C+ G Sbjct: 2727 -----PEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARG 2781 Query: 1470 GPGPVGNSTFAWFWN---------DRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAA 1520 P P N T W+ + + +P L ++ AG Y C AE G A Sbjct: 2782 SPEP--NIT----WDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRA 2835 Query: 1521 ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQG 1580 V L +L P T+ G R L C P + + R V Sbjct: 2836 RRR-VHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG---- 2890 Query: 1581 APAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631 V + A+ D G Y+C A N +G ++ V+ Sbjct: 2891 --------VSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 2933 Score = 202 bits (515), Expect = 2e-51 Identities = 373/1573 (23%), Positives = 580/1573 (36%), Gaps = 263/1573 (16%) Query: 194 TGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNIL 253 + VG L L A Q+ C V N + ++ L+V P+ P+ +++ Sbjct: 932 SAVGRLLYLGQAQLAQEGTYTCECSNVVGN--SSQDLQLEVHVPPQIAGPREPPTQVSVV 989 Query: 254 PGELVTLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTC 305 + TL C P ++ W +DG ++LQ + LH+ +A + G Y+C Sbjct: 990 QDGVATLECNATGKPPP--TVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 1047 Query: 306 QAENGVGSLVSPPISLHIFMAEVQVSPAGPILE-----NQTVTLVCNTPNEAPSDLRYSW 360 AEN G L + + + P+ + +TL+C P +R W Sbjct: 1048 VAENLAGR-AERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIR--W 1104 Query: 361 YKNHVLL---EDAH----SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413 ++ + ED + L++ D+G Y C N G R SV V PP Sbjct: 1105 FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRN-FSVEVLVPPS 1163 Query: 414 --TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGP 471 L ++ G L C+V P L G LA GD+ H P Sbjct: 1164 IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR--GDAHHI-------SP 1214 Query: 472 NSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAE-------VVEG 524 + + L++ + +G Y C A N++G T A ++ A + V Sbjct: 1215 DGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVN 1274 Query: 525 QAVTLSCRSGLSPTPDARFSWYLNGALLHEG------PGS-SLLLPAASSTDAGSYHCRA 577 ++L C + P+P+ +W +GA PG+ L + A DAG Y C Sbjct: 1275 NPISLICEALAFPSPN--ITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVV 1332 Query: 578 RDGHSASGPSSPAVLTVLYPPR--QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635 + + + + VL PP + + + L C + PP ++ Sbjct: 1333 TNELGEAVKNYH--VEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIR 1390 Query: 636 LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695 +KD T S R++V LL+++ + + G YLC A+N Sbjct: 1391 W-YKDGQPVTP-------------SSRLQVLGEGRLLQIQPTQ--VSDSGRYLCVATNVA 1434 Query: 696 GNASTS--------------ATFNGQATVLA--------IAPSHTLQEGTEANLTCNVSR 733 G F+ +L+ + + E A L C+ + Sbjct: 1435 GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTN- 1493 Query: 734 EAAGSPANFSWFRNGVLWAQGPLETVTL------LPVARTD-AALYACRILTEAGAQLST 786 A P + +W+R + G +V +P+ R + A Y+C+ E G Sbjct: 1494 --AIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 1551 Query: 787 PVLLSVLYPP----DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGP 842 LL VL PP D +L + + C P+ ++ + S Sbjct: 1552 YELL-VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRL 1610 Query: 843 QVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSP 902 QV G+ L+V + D+ SY C A N GS+ F +R VQV P Sbjct: 1611 QVLEDGQV----------LQVSTAEVADAASYMCVAENQAGSAEK--LFTLR---VQVPP 1655 Query: 903 ---SPELQEGQAVV-----LSCQVHTGV-PEGTSYRWYRDGQPLQESTSA-------TLR 946 +L++ A++ L C VH PE T WY+D Q L TL+ Sbjct: 1656 RIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT---WYKDSQALSLGEEVFLLPGTHTLQ 1712 Query: 947 FAAITLTQAGAYHCQA-QAPG--SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLL 1003 L+ +G Y C+A A G L+ + APR L+ G +L Sbjct: 1713 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDK--AVL 1770 Query: 1004 LCRVDSDP-PAQLRLLHGDRLV-ASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061 C D+ P P G LV A Q + G + RLEI A + D Sbjct: 1771 SCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ---------------RLEIQEAQVSD 1815 Query: 1062 EGVYICEASNTLGQASASADFDAQAVNVQVWPGA-TVRE--GQLVNLTCLVWTTHPAQLT 1118 +G+Y C+ SN G+A + Q P TV + G + LTC V + PA T Sbjct: 1816 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAP-T 1873 Query: 1119 YTWYQDGQQRLDAHSIPLPNVTVR------------DATSYRCGVGPPGRAPRLSRPITL 1166 TW +D R+ S + V R A +Y C R + + Sbjct: 1874 VTWLKD---RMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR--KDFVV 1928 Query: 1167 DVLYAPRNLRLTYLLESH---GGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT 1223 VL APR +R + + H GQ + C D +PP +A G L + Sbjct: 1929 AVLVAPR-IRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY 1987 Query: 1224 L---RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP---EAAVPEGAPI 1277 L L L+G + D G Y+C A +P G+ + RL V V++ P + A G + Sbjct: 1988 LDGGSLVLKGLRASDAGAYTCVAHNPAGE-----DARLHTVNVLVPPTIKQGADGSGTLV 2042 Query: 1278 T-----VTCADPAAHAPTLY-TWYHNG-------RWLQEGPAASLSFLVATRAHAGAYSC 1324 + VT P +P ++ +W +G R L G +L A AG ++C Sbjct: 2043 SRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC 2102 Query: 1325 QAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRA--RSMAVIQCTVDSEPPAELALSHD 1382 A G + R LQV P + D S+ + C P ++ D Sbjct: 2103 VAASPAGV-ADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD 2161 Query: 1383 GKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQ 1441 G+ L + SL G LQ++ V AGD TY C A + G +L Sbjct: 2162 GEPLLS----QSLEQGPS----------LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 2207 Query: 1442 VEGARVVAEPG----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLA 1497 V + + G L + GA + L C G P P W + + L + A Sbjct: 2208 VMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQP----NITWHKDGQALTRLENNSRA 2263 Query: 1498 FTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYP-----PKTPTMMVFVEPEGGLRGIL 1552 + AG+Y CLAE P GA + +RV P P+ P +V + P G L +L Sbjct: 2264 TRVLRVRDAGLYTCLAESPAGAIEKS-FRVRVQAPPNIVGPRGPRFVVGLAP-GQL--VL 2319 Query: 1553 DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612 +C V++EP +T H G + H + ++AL +D G+Y Sbjct: 2320 ECSVEAEPAPKITWH----------RDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYS 2369 Query: 1613 CSASNVLGSASTS 1625 C+A N GS S + Sbjct: 2370 CTARNAAGSTSVA 2382 Score = 201 bits (511), Expect = 5e-51 Identities = 379/1557 (24%), Positives = 563/1557 (36%), Gaps = 298/1557 (19%) Query: 258 VTLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTCQAEN 309 V+L C V++ +P + W KD V L T L L +A SD+G+YTC+A N Sbjct: 1673 VSLPCDVHA-HPN-PEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALN 1730 Query: 310 GVG---SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVL 366 G LV + + + P +L V + +A + +WYK+ Sbjct: 1731 AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQP 1790 Query: 367 LEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPP-LTPVLT 418 L A L + A +D G Y C+V NV G E ++ V PP T Sbjct: 1791 LVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKT 1849 Query: 419 AFLETQAGLVGILHCSVVSEPLATL--------VLSHGGHILASTSGDSDHSPRFSGTSG 470 + AG +L C V P T+ V S H + S G Sbjct: 1850 ETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGG------------- 1896 Query: 471 PNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN---AARLLISPAAE---VVEG 524 RL++ L+ +G Y C A N+ A DF A R+ S A V+EG Sbjct: 1897 ----RLQLSRLQPAQAGTYTCVAENTQAEARK--DFVVAVLVAPRIRSSGVAREHHVLEG 1950 Query: 525 QAVTLSCRSGLSPTPDARFSWYLNGALLHE--GP-------GSSLLLPAASSTDAGSYHC 575 Q V L C + P PD +W +G+ L + GP G SL+L ++DAG+Y C Sbjct: 1951 QEVRLDCEADGQPPPDV--AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2008 Query: 576 RARDGHSASGPSSPA-VLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLL---CRVDSDPP 631 A H+ +G + + VL PP T + D +G R G L+ C V PP Sbjct: 2009 VA---HNPAGEDARLHTVNVLVPP-----TIKQGADGSGTLVSRPGELVTMVCPVRGSPP 2060 Query: 632 ARLQLL------------------HKDRVVATSLPSGGGCSTCGGCSPR--------MKV 665 + L H R+ L + G TC SP ++V Sbjct: 2061 IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQL-ADAGIFTCVAASPAGVADRNFTLQV 2119 Query: 666 TKAPNLLRVEIHNPLLEEEGLYL---CEASN----------------------------- 693 P L VE N ++ G + CEA Sbjct: 2120 QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLE 2179 Query: 694 ALGNASTSATFN-------GQAT----VLAIAPSHTLQEG--TEANLTCNVSRE----AA 736 A+G A S T++ G+A + + P H G TE +LT E A Sbjct: 2180 AVG-AGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 2238 Query: 737 GSPA-NFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP 795 G+P N +W ++G + + + DA LY C + AGA + + V P Sbjct: 2239 GTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGA-IEKSFRVRVQAP 2297 Query: 796 PD-----RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRF 850 P+ P+ L GQ + C+V++ P + +L Q P GRF Sbjct: 2298 PNIVGPRGPRFVVGLAPGQ---LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF 2354 Query: 851 QAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV----SPSPEL 906 L+++ L DSG Y C A N GS TS+ F+V V P+ + Sbjct: 2355 ----------LQLQALSTADSGDYSCTARNAAGS--TSVAFRVEIHTVPTIRSGPPAVNV 2402 Query: 907 QEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST-------SATLRFAAITLTQAGAYH 959 Q +L CQ GVP W +D PL + +LR + AG Y Sbjct: 2403 SVNQTALLPCQAD-GVP-APLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL 2460 Query: 960 CQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDP-PAQLRL 1017 C A + GS + + AP LT T LL C P P + Sbjct: 2461 CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTP----ALLPCEASGSPKPLVVWW 2516 Query: 1018 LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQAS 1077 G +L QG S+ L A P +D + C SN +G+A Sbjct: 2517 KDGQKLDFRLQQGAYRLLPSNALLLTAPGP------------QDSAQFECVVSNEVGEAH 2564 Query: 1078 ASADFDAQAVNVQVWPGATVREGQ----LVNLTCLVWTTHPAQL---TYTWYQDGQQRLD 1130 V V V P T+ + Q + + +V T H + T +W + G Q L Sbjct: 2565 R-----LYQVTVHVPP--TIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ-LG 2616 Query: 1131 AHSIPLPNVTVRDATSYRCGVGPPGRAPRLS-----------RPITLDVLYAPRNLRLTY 1179 A V + + G P A R + + + L V +P L Sbjct: 2617 ARG---SGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPS 2673 Query: 1180 LLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFY 1239 ++ + + L+ C P + G +A+ + V +L + P D G Y Sbjct: 2674 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNY 2733 Query: 1240 SCSARSPLGQA--NTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN 1297 C A++ G A T L +++ V P+ + EG+ + C + P + TW + Sbjct: 2734 LCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNI-TWDKD 2792 Query: 1298 GRWLQ--EG-----PAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAV 1350 G+ + EG P+ L AG Y+C A++A G R+ R L +L P Sbjct: 2793 GQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG-RARRRVHLTILVLPVFTT 2851 Query: 1351 LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR 1410 L R R ++C P + + + + + S V+R Sbjct: 2852 LPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSRE--- 2908 Query: 1411 LQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV---AEPGLDVPEGAALNLSCRL 1467 TYVC A+N +G + + V+ A V+ A L P G ++ L C + Sbjct: 2909 --------DSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV 2960 Query: 1468 LGGPGPVGNSTFAWFWNDRRL------HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAA 1521 G P P W + L H +L R AG Y CLAE G A Sbjct: 2961 RGDPVP----DIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAK 3016 Query: 1522 SAPVMLRVLYPPKTPTMMVF-VEPE-----GGLRGILDCRVDSEPLASLT-LHLGSRLVA 1574 +++ P VF VEP+ G L C+ EP ++ L G L A Sbjct: 3017 KVVILVLQSAP-------VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRA 3069 Query: 1575 SSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631 S + + P + +E + D G Y C A N+LGSA+ + VR Sbjct: 3070 SRRLRTLPDGS------------LWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3114 Score = 180 bits (457), Expect = 9e-45 Identities = 398/1681 (23%), Positives = 604/1681 (35%), Gaps = 297/1681 (17%) Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRV---PTIASPVELLEGTEV 156 L ++ Q D+GSY R S V ++++ L V PR+ P++ PV L T V Sbjct: 659 LRIEQAQLSDAGSY--RCVASNVAGSTELRYGL-RVNVPPRITLPPSLPGPV--LVNTPV 713 Query: 157 DFNCSTPYVCLQEQVRLQW--QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRI 214 C+ L W G + + T Q F G + TL A + D GR Sbjct: 714 RLTCNATGA---PSPTLMWLKDGNPVSPAGTPGLQVFPG---GRVLTLASARA-SDSGRY 766 Query: 215 LRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSI 274 +S Q ++ LQV P IL +++ E V L CQ ++ P V S Sbjct: 767 SCVAVSAVGEDRQ-DVVLQVHMPPS---ILGEELNVSVVANESVALECQSHAMPPPVLS- 821 Query: 275 KWLKDGVRLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA 326 W KDG L+ + GV L + +A DAG YTC+A N G S + Sbjct: 822 -WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGH------SEKHYNL 874 Query: 327 EVQVSPAGPILENQTVTLVCNTPNEAPSDLR------YSWYKNHVLLE---------DAH 371 V V+P P+ E+ T+T+ P + R SW K+ L A Sbjct: 875 NVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAV 934 Query: 372 SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTP----VLTAFLETQAGL 427 L L A A G Y CE NV G+ S + + V+ PP T Q G Sbjct: 935 GRLLYLGQAQLAQEGTYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDG- 992 Query: 428 VGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487 V L C+ +P T+ G + + G + S L + + +G Sbjct: 993 VATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQS---------LHVERAQAAHTG 1043 Query: 488 EYKCSATNSLGNATSTLDFHANAARLLIS---PAAEVVEG--QAVTLSCRSGLSPTPDAR 542 Y C A N G A + LI P + +TL C + P P R Sbjct: 1044 RYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIR 1103 Query: 543 FSWYLNGALLHEGPGSSLL-------LPAASSTDAGSYHCRARDGHSASGPSSPAVLTVL 595 W+ + G + LL + D+G Y C A + A + VL Sbjct: 1104 --WFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA--SNEAGEARRNFSVEVL 1159 Query: 596 YPPRQPTFTTRLDLDAA-GAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCS 654 PP DL+ G+ L+C V P +L R +A Sbjct: 1160 VPPS----IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR--------- 1206 Query: 655 TCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIA 714 G + + +P+ + +++ L G Y C A+NA+G T + Q +VL +A Sbjct: 1207 ---GDAHHI----SPDGVLLQVLQANLSSAGHYSCIAANAVG----EKTKHFQLSVL-LA 1254 Query: 715 PS--HTLQEGTEANLTCNVSR------EAAGSPA-NFSWFRNGVLWAQGPLETVTLLP-- 763 P+ ++ + +T V+ EA P+ N +W ++G + + LLP Sbjct: 1255 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEAS--RNIQLLPGT 1312 Query: 764 -------VARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFI 816 + DA Y C + E G + + VL PP K L ++G + + Sbjct: 1313 HGLQILNAQKEDAGQYTCVVTNELGEAVKN-YHVEVLIPPSISKDDPLAEVGVKEVKTKV 1371 Query: 817 -------CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869 C + P + + + S QV GR L+++ + Sbjct: 1372 NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL----------LQIQPTQVS 1421 Query: 870 DSGSYRCEATNVLGSSNTSL--------FFQVRG--------------AWVQVSPSPELQ 907 DSG Y C ATNV G + FQ G A V+ E+ Sbjct: 1422 DSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIV 1481 Query: 908 EGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT-------LRFAAITLTQAGAYHC 960 E L C + P + WYR+ QPL + L+ + AG Y C Sbjct: 1482 ENNPAYLYCDTNAIPPPDLT--WYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSC 1539 Query: 961 QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020 +A ++ LH Y +T ++ + + S Q L Sbjct: 1540 KA-------SNEVGEDWLH--YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN 1590 Query: 1021 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080 S LQ G P SPRL V L++ A + D Y+C A N G A Sbjct: 1591 PVPTISWLQN-GLPFSPSPRLQVLEDGQV--LQVSTAEVADAASYMCVAENQAGSAE--- 1644 Query: 1081 DFDAQAVNVQVWP--------GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL--- 1129 + VQV P T V+L C V HP TWY+D Q Sbjct: 1645 --KLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDV-HAHP-NPEVTWYKDSQALSLGE 1700 Query: 1130 ------DAHSIPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVL------YAPRNLR 1176 H++ L + D+ Y C + GR +L + L VL APR + Sbjct: 1701 EVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL---VQLSVLVPPAFRQAPRGPQ 1757 Query: 1177 LTYLLESHGGQLALVLCTVDSRPPAQLALSHAGR-LLASSTAASVPNTLRLELRGPQPRD 1235 L+ G A++ C D+ P + G+ L+ + ++ RLE++ Q D Sbjct: 1758 DAVLVRV--GDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSD 1815 Query: 1236 EGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE---GAPITVTCADPAAHAPTLY 1292 +G YSC + G+A + L ++ P+ G+P+ +TC APT+ Sbjct: 1816 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV- 1874 Query: 1293 TWYHNGRWLQEGP-------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYA 1345 TW + ++ L A AG Y+C A++ Q + + + VL A Sbjct: 1875 TWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQ-AEARKDFVVAVLVA 1933 Query: 1346 PQDAVLSSFRDSRARSMAVIQ--CTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403 P+ R+ ++ C D +PP ++A DG L G H G Sbjct: 1934 PRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSL 1993 Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV-------EGA----RVVAEPG 1452 V + L+ D A Y C A N G + + + V +GA +V+ P Sbjct: 1994 VLKG---LRASDAGA----YTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRP- 2045 Query: 1453 LDVPEGAALNLSCRLLGGPGPVGNSTFAWF-------WNDRRLHAEPVPTLAFTHVARAQ 1505 G + + C + G P P+ S W + R L TL + V A Sbjct: 2046 -----GELVTMVCPVRGSP-PIHVS---WLKDGLPLPLSQRTLLHGSGHTLRISKVQLAD 2096 Query: 1506 AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI---LDCRVDSEPLA 1562 AG++ C+A P G A L+V PP + F +RG L C PL Sbjct: 2097 AGIFTCVAASPAG-VADRNFTLQVQVPPVLEP-VEFQNDVVVVRGSLVELPCEARGVPLP 2154 Query: 1563 SLT-LHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621 ++ + G L++ S QG + +EA+ D G Y C A + G Sbjct: 2155 LVSWMKDGEPLLSQSLEQGP---------------SLQLEAVGAGDSGTYSCVAVSEAGE 2199 Query: 1622 A 1622 A Sbjct: 2200 A 2200 Score = 176 bits (446), Expect = 2e-43 Identities = 381/1579 (24%), Positives = 580/1579 (36%), Gaps = 296/1579 (18%) Query: 200 ETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVT 259 ++LH+ + H C RA+ + L V P+ + L + +T Sbjct: 1030 QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLT 1089 Query: 260 LTCQVNSSYPAVSSIKWLK--------DGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGV 311 L C+ P +I+W + + L +L + Q D+G+Y+C A N Sbjct: 1090 LLCEAMGIPPP--AIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEA 1147 Query: 312 GSLVSPPISLHIFMAEVQVSPAGP---------ILENQTVTLVCNTPNEAPSDLRYSWYK 362 G + F EV V P+ +L+ QT L+CN L +W+K Sbjct: 1148 GE------ARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFK 1199 Query: 363 NHVLLEDAHSH-------TLRLHLATRADTGFYFCEVQNVHGSE-RSGPVSVVVNHPPLT 414 + L +H L++ A + G Y C N G + + +SV+ L Sbjct: 1200 DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL-----LA 1254 Query: 415 PVLTAFLETQAG---LVGI-----LHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466 P + E A V + L C ++ P + G + S + Sbjct: 1255 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEA----SRNIQLLP 1310 Query: 467 GTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA-------A 519 GT G L+I + ++ D+G+Y C TN LG A ++H +LI P+ A Sbjct: 1311 GTHG-----LQILNAQKEDAGQYTCVVTNELGEAVK--NYH---VEVLIPPSISKDDPLA 1360 Query: 520 EV-------VEGQAVTLSCRSGLSPTPDARFSWYLNG-------ALLHEGPGSSLLLPAA 565 EV +TL C S P P R WY +G L G G L + Sbjct: 1361 EVGVKEVKTKVNSTLTLECESWAVPPPTIR--WYKDGQPVTPSSRLQVLGEGRLLQIQPT 1418 Query: 566 SSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP---RQPTFTTRLDL-----DAAGAGAG 617 +D+G Y C A + ++ V PP + F+ ++ +A G Sbjct: 1419 QVSDSGRYLCVATNVAGEDDQDFNVLIQV--PPMFQKVGDFSAAFEILSREEEARGGVTE 1476 Query: 618 RRGL-------LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPN 670 R + L C ++ PP L +D+ L +G S G +V + P Sbjct: 1477 YREIVENNPAYLYCDTNAIPPPDLTWYREDQ----PLSAGDEVSVLQG----GRVLQIP- 1527 Query: 671 LLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCN 730 L+R E G Y C+ASN +G + + + L E N + Sbjct: 1528 LVRA-------ENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASST 1580 Query: 731 VSRE--AAGSPA-NFSWFRNGVLWAQGP----LETVTLLPVAR---TDAALYACRILTEA 780 VS + A G+P SW +NG+ ++ P LE +L V+ DAA Y C +A Sbjct: 1581 VSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQA 1640 Query: 781 GAQLSTPVLLSVLYPP-----DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHL 835 G+ L V PP D +++A+L+ C V + P + + Sbjct: 1641 GS-AEKLFTLRVQVPPRIAGLDLEQVTAILNSS----VSLPCDVHAHPNPEVTWYKDSQ- 1694 Query: 836 LATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN--TSLFFQV 893 A SLG +V + L++ L DSG Y CEA N G L V Sbjct: 1695 -ALSLGEEV--------FLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV 1745 Query: 894 RGAWVQVSPSPE----LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP--LQESTSA---- 943 A+ Q P+ ++ G VLSC+ +PE T WY+DGQP L + T A Sbjct: 1746 PPAFRQAPRGPQDAVLVRVGDKAVLSCET-DALPEPT-VTWYKDGQPLVLAQRTQALRGG 1803 Query: 944 -TLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYA-PRHVTLTTLMDTGPGRL 1000 L ++ G Y C+ + G A + + + ++ P+ T++ + G Sbjct: 1804 QRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQV----AGSP 1859 Query: 1001 GLLLCRVDSDPPAQLRLLHGDRL--VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAM 1058 +L C V P + L DR+ +S + GV G RL++ Sbjct: 1860 LVLTCDVSGVPAPTVTWLK-DRMPVESSAVHGVVSRGG--------------RLQLSRLQ 1904 Query: 1059 LEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGAT---------VREGQLVNLTCLV 1109 G Y C A NT QA A DF V V V P V EGQ V L C Sbjct: 1905 PAQAGTYTCVAENT--QAEARKDF---VVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEA 1959 Query: 1110 WTTHPAQLTYTWYQDGQQ-----------RLDAHSIPLPNVTVRDATSYRC-GVGPPGRA 1157 P + W +DG LD S+ L + DA +Y C P G Sbjct: 1960 DGQPPPDV--AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 2017 Query: 1158 PRLSRPITLDVLYAP---RNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLAS 1214 RL T++VL P + + L S G+L ++C V PP ++ G L Sbjct: 2018 ARLH---TVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL 2074 Query: 1215 STAASVPNT-LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP-----E 1268 S + + L + Q D G ++C A SP G A+ + L+++ V +L P + Sbjct: 2075 SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ-VPPVLEPVEFQND 2133 Query: 1269 AAVPEGAPITVTCADPAAHAPTLYTWYHNG-----RWLQEGPAASLSFLVATRAHAGAYS 1323 V G+ + + C P L +W +G + L++GP+ L + A +G YS Sbjct: 2134 VVVVRGSLVELPCEARGVPLP-LVSWMKDGEPLLSQSLEQGPSLQLEAVGA--GDSGTYS 2190 Query: 1324 CQAQDAQGTRSSRPAALQVLYAP--QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSH 1381 C A G + R L V+ P +D+ + + + C P + Sbjct: 2191 CVAVSEAG-EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK 2249 Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQ 1441 DG+ L T +R L+V+D Y C A++ G+I R+ Sbjct: 2250 DGQAL------------TRLENNSRATRVLRVRDA----GLYTCLAESPAGAIEKSFRV- 2292 Query: 1442 VEGARVVAEPGLDVPEG---------AALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP 1492 RV A P + P G L L C + P P W D + E Sbjct: 2293 ----RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAP----KITWH-RDGIVLQED 2343 Query: 1493 VPT--------LAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLY--PPKTPTMMVFV 1542 T L ++ A +G Y C A AA S V RV P + V Sbjct: 2344 AHTQFPERGRFLQLQALSTADSGDYSCTAR---NAAGSTSVAFRVEIHTVPTIRSGPPAV 2400 Query: 1543 EPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEA 1602 +L C+ D P A L R+ P P +L +LR I+ Sbjct: 2401 NVSVNQTALLPCQADGVP-APLVSWRKDRVPLD------PRSPRFEILPE-GSLR--IQP 2450 Query: 1603 LRPSDQGEYICSASNVLGS 1621 + D G Y+C ASN GS Sbjct: 2451 VLAQDAGHYLCLASNSAGS 2469 Score = 162 bits (409), Expect = 3e-39 Identities = 357/1546 (23%), Positives = 551/1546 (35%), Gaps = 319/1546 (20%) Query: 253 LPGELVTLTCQVNSSYPAVSSIKWLKD-----------------------GVRLQTKTGV 289 + G+ +TL C N +P V I WLKD G RL + Sbjct: 31 MAGQSLTLECDANG-FP-VPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQS 88 Query: 290 LHLPQAAWSDAGVYTCQAENGVGS--------LVSPPISLHIFMAEVQVSPAGPILENQT 341 LH P+ D+G+Y+C+AEN G+ +++PP L A+ + AG +E Q Sbjct: 89 LHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQC 148 Query: 342 VTLVCNTPNEAPSDLRYSWYKN---------HVLLEDAHSHTLRLHLATRADTGFYFCEV 392 T TP + W K+ H+ +++ LR+ + D G Y C Sbjct: 149 WTSGVPTP-------QVEWTKDRQPVLPGGPHLQVQE-DGQVLRITGSHVGDEGRYQCVA 200 Query: 393 QNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILH-------CSVVSEPLATLVL 445 + G +++ + V+ PP T + + G V ++ C P + Sbjct: 201 FSPAG-QQARDFQLRVHAPP-----TIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW 254 Query: 446 SHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD 505 G +L + S + T G +L++ + +D+G Y C A+N++G A Sbjct: 255 FKDGALLPT-------STKVVYTRG--GRQLQLGRAQSSDAGVYTCKASNAVGAAEK--- 302 Query: 506 FHANAARLLISPAAE----------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEG 555 A + + P E V G+ V L C + P+P SW+ G + E Sbjct: 303 --ATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP--TLSWHHEGLPVAES 358 Query: 556 -------PGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVL----TVLYPPRQPTFT 604 GS L L + +G Y C AS P+ AVL V PP+ Sbjct: 359 NESRLETDGSVLRLESPGEASSGLYSC------VASSPAGEAVLQYSVEVQVPPQL---- 408 Query: 605 TRLDLDAAGAG-----AGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGC 659 L A G G G+ L C+ P +Q L R A L Sbjct: 409 ----LVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR-PAEELAG---------- 453 Query: 660 SPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG--NASTSATFNGQ-ATVLAIAPS 716 V A + I + L+ GL+ C+A+N G A + +G+ A + P Sbjct: 454 -----VQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPI 508 Query: 717 HTLQEGTEANLTCNVSREA---------AGSPANFSWFRNGVLWAQ--GPLETVTLLP-- 763 G E + + + + P W G LW + G +L P Sbjct: 509 GQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPL 568 Query: 764 ----VARTDAALYACRILTEAGAQLSTPVLLSVLYPPD---RPKLSALLDMGQGHMALFI 816 V D +Y C AG + V L VL PP+ P A+L+ Sbjct: 569 QIEKVDLRDEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENAS---VTLE 624 Query: 817 CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRC 876 C P ++ F G +++ +G V GR L + + L D+GSYRC Sbjct: 625 CLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----------LRIEQAQLSDAGSYRC 674 Query: 877 EATNVLGSSNTSLFFQVRGAWVQVSPS---PELQEGQAVV-----LSCQVHTGVPEGTSY 928 A+NV GS T L + +R V V P P G +V L+C TG P T Sbjct: 675 VASNVAGS--TELRYGLR---VNVPPRITLPPSLPGPVLVNTPVRLTCNA-TGAPSPT-L 727 Query: 929 RWYRDGQPLQESTS---------ATLRFAAITLTQAGAYHCQA-QAPGSATTSLAAPISL 978 W +DG P+ + + L A+ + +G Y C A A G + + + Sbjct: 728 MWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHM 787 Query: 979 HVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSS 1038 S + ++ + + L C+ + PP L R + Sbjct: 788 PPSILGEELNVSVVANESVA----LECQSHAMPPPVLSWWKDGRPL-------------E 830 Query: 1039 PRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVR 1098 PR V ++ + L++ A + D G Y CEA N G + + +NV V P +R Sbjct: 831 PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYN-----LNVWVAPVFPLR 885 Query: 1099 EGQLVNLTCLVWTTHPAQLT----------YTWYQDGQ---------QRLDA--HSIPLP 1137 E T V HP +L+ +W +DGQ Q + A + L Sbjct: 886 ESH----TLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLG 941 Query: 1138 NVTVRDATSYRCGVGPPGRAPRLSRPITLDV-----LYAPRNLRLTYLLESHGGQLALVL 1192 + +Y C S+ + L+V + PR + G +A + Sbjct: 942 QAQLAQEGTYTCECS--NVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDG--VATLE 997 Query: 1193 CTVDSRPPAQLALSHAGRLLASSTAASVPNT-LRLELRGPQPRDEGFYSCSARSPLGQAN 1251 C +PP + G+ + + + N L + Q G YSC A + G+A Sbjct: 998 CNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAE 1057 Query: 1252 TSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNG------RWLQ-EG 1304 EL +L P + + P+T A A H+P G RW + E Sbjct: 1058 RKFELS------VLVPPELIGDLDPLTNITA--ALHSPLTLLCEAMGIPPPAIRWFRGEE 1109 Query: 1305 PAA------------SLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP--QDAV 1350 P + L +G YSC A + G + R +++VL P ++ Sbjct: 1110 PVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAG-EARRNFSVEVLVPPSIENED 1168 Query: 1351 LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR 1410 L A + C V P +L DG+ LA H G +QV Sbjct: 1169 LEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGV-LLQV------ 1221 Query: 1411 LQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV-------EGARVVAEPGLDVPEGAALNL 1463 LQ AG Y C A N +G + +L V GA A+ + V ++L Sbjct: 1222 LQANLSSAGH--YSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISL 1279 Query: 1464 SCRLLGGPGPVGNSTF----AWFWNDRRLHAEP-VPTLAFTHVARAQAGMYHCLAELPTG 1518 C L P P N T+ A F R + P L + + AG Y C+ G Sbjct: 1280 ICEALAFPSP--NITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 1337 Query: 1519 AAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASS-- 1576 A + VL PP + + L + V ++ ++LTL S V Sbjct: 1338 EAVK-NYHVEVLIPPS-------ISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTI 1389 Query: 1577 --QPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620 G P P + + I+ + SD G Y+C A+NV G Sbjct: 1390 RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAG 1435 Score = 155 bits (391), Expect = 4e-37 Identities = 382/1680 (22%), Positives = 580/1680 (34%), Gaps = 292/1680 (17%) Query: 105 LQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELL--EGTEVDFNCST 162 +Q DSG Y+ R E D ++T P V + E+L G +V+ C T Sbjct: 94 IQEGDSGLYSCRAENQAGTAQRDFHLLVLT---PPSVLGAGAAQEVLGLAGADVELQCWT 150 Query: 163 PYVCLQEQVRLQW-QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSV 221 V + ++W + + P + Q E V + H+ D GR S Sbjct: 151 SGVPTPQ---VEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG----DEGRYQCVAFSP 203 Query: 222 ANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGV 281 A +A+ + L+V +AP + ++ LV L C+ +I W KDG Sbjct: 204 AGQQAR-DFQLRV-HAPPTIWGSNETGEVAVMEDHLVQLLCEARGV--PTPNITWFKDGA 259 Query: 282 RLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPA 333 L T T V L L +A SDAGVYTC+A N VG+ L +++ Sbjct: 260 LLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAG 318 Query: 334 G-----PILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH-------SHTLRLHLAT 381 G + + V L C L SW+ + + +++ LRL Sbjct: 319 GRPYVVKAVAGRPVALECVARGHPSPTL--SWHHEGLPVAESNESRLETDGSVLRLESPG 376 Query: 382 RADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF--LETQAGLVGILHCSVVSEP 439 A +G Y C + G E SV V PP V + T G L C P Sbjct: 377 EASSGLYSCVASSPAG-EAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP 435 Query: 440 LATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGN 499 + T+ G +G S GT+ L I +E SG + C ATN G Sbjct: 436 VPTIQWLQNGRPAEELAGVQVAS---QGTT------LHIDHVELDHSGLFACQATNEAGT 486 Query: 500 ATSTLDFHAN---AARLLISPAAEVVEG----QAVTLSCRS------GLSPTPDARFSWY 546 A + ++ + A +L P + G + +C G P P W Sbjct: 487 AGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWC 546 Query: 547 LNGALLHEGPG--------SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598 G+L E G L + D G Y C A + A L VL PP Sbjct: 547 SPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT--NLAGESKREVALKVLVPP 604 Query: 599 R-QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCG 657 +P + L+ A L C PP + + V Sbjct: 605 NIEPGPVNKAVLENASV------TLECLASGVPPPDVSWFKGHQPV-------------- 644 Query: 658 GCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATV---LAIA 714 S M VT + + + I L + G Y C ASN G ST + + V + + Sbjct: 645 --SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG--STELRYGLRVNVPPRITLP 700 Query: 715 PS--HTLQEGTEANLTCNVSREAAGSPA-NFSWFRNG--VLWAQGP-------LETVTLL 762 PS + T LTCN A G+P+ W ++G V A P +TL Sbjct: 701 PSLPGPVLVNTPVRLTCN----ATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLA 756 Query: 763 PVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSR 822 +D+ Y+C ++ G V+L V PP + + C + Sbjct: 757 SARASDSGRYSCVAVSAVGED-RQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAM 815 Query: 823 PLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVL 882 P +L+ + P R A+ L+V + D+G Y CEA N Sbjct: 816 PPPVLSWWKDGR----------PLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 865 Query: 883 GSSNTSLFFQVRGAWV------QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP 936 G S V WV + S + ++EG LSC+ GVP W +DGQP Sbjct: 866 GHSEKHYNLNV---WVAPVFPLRESHTLTVREGHPTRLSCECR-GVP-FPKISWRKDGQP 920 Query: 937 LQESTSATLRFAAI---------TLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYA-PR 985 L + +A+ L Q G Y C+ + G+++ L + + A PR Sbjct: 921 LPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPR 980 Query: 986 H-VTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVA 1044 T +++ G + L C PP + T + G P G+ L + Sbjct: 981 EPPTQVSVVQDG---VATLECNATGKPPPTV-----------TWERDGQPVGAELGLQLQ 1026 Query: 1045 VAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVN 1104 +L +E A G Y C A N G+A + ++V V P L N Sbjct: 1027 NQGQSLHVE--RAQAAHTGRYSCVAENLAGRAERKFE-----LSVLVPPELIGDLDPLTN 1079 Query: 1105 LTCLVWTTHPAQL----------TYTWY---------QDGQQRLDAHSIPLPNVTVRDAT 1145 +T + + P L W+ +D + + +D+ Sbjct: 1080 ITAALHS--PLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSG 1137 Query: 1146 SYRCGVGPPGRAPRLSRPITLDVLYAP--RNLRLTYLLESHGGQLALVLCTVDSRPPAQL 1203 Y C A R +++VL P N L +++ GQ A ++C V P +L Sbjct: 1138 LYSCLAS--NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL 1195 Query: 1204 ALSHAGRLLASSTAASV-PNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVR 1262 GR LA A + P+ + L++ G YSC A + +G+ +L Sbjct: 1196 TWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQL-----S 1250 Query: 1263 VILAP------------EAAVPEGAPITVTCADPAAHAPTLYTWYHNG------RWLQEG 1304 V+LAP E V PI++ C A +P + TW +G R +Q Sbjct: 1251 VLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNI-TWMKDGAPFEASRNIQLL 1309 Query: 1305 PAA-SLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP---QDAVLSSFR----D 1356 P L L A + AG Y+C + G + + ++VL P +D L+ Sbjct: 1310 PGTHGLQILNAQKEDAGQYTCVVTNELG-EAVKNYHVEVLIPPSISKDDPLAEVGVKEVK 1368 Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416 ++ S ++C + PP + DG+ + SS + L G LQ+Q Sbjct: 1369 TKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR----------LLQIQPT 1418 Query: 1417 PAGDD-TYVCTAQNLLGS--------------ISTIGRLQV--------EGARVVAEPGL 1453 D Y+C A N+ G +G E AR Sbjct: 1419 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 1478 Query: 1454 DVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA-------EPVPTLAFTHVARAQA 1506 ++ E L C P P W+ D+ L A + L V A Sbjct: 1479 EIVENNPAYLYCDTNAIPPP----DLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENA 1534 Query: 1507 GMYHCLAELPTGAAASAPVMLRVLYPP----KTPTMMVFVEPEGGLRGILDCRVDSEPLA 1562 G Y C A G +L VL PP T ++ V L C P+ Sbjct: 1535 GRYSCKASNEVGEDWLHYELL-VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVP 1593 Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622 ++ S G P P + + + + +D Y+C A N GSA Sbjct: 1594 TI----------SWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA 1643 Score = 149 bits (375), Expect = 3e-35 Identities = 309/1299 (23%), Positives = 445/1299 (34%), Gaps = 234/1299 (18%) Query: 251 NILPGELVTLTCQVNSSYPAVSSIKWLKDG----------VRLQTKTGVLHLPQAAWSDA 300 ++L G+ V L C+ + P + WLKDG +R G L L SDA Sbjct: 1946 HVLEGQEVRLDCEADGQPPP--DVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA 2003 Query: 301 GVYTCQAENGVGS---------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNE 351 G YTC A N G LV P I + VS G + VT+VC Sbjct: 2004 GAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGEL-----VTMVCPVRGS 2058 Query: 352 APSDLRYSWYKNHVLLE-------DAHSHTLRLHLATRADTGFYFCEVQNVHG-SERSGP 403 P + SW K+ + L HTLR+ AD G + C + G ++R+ Sbjct: 2059 PP--IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFT 2116 Query: 404 VSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP 463 + V V P L PV E Q +V VV L L G L S D P Sbjct: 2117 LQVQVP-PVLEPV-----EFQNDVV------VVRGSLVELPCEARGVPLPLVSWMKDGEP 2164 Query: 464 RFSGT--SGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEV 521 S + GP+ L++ + DSG Y C A + G A ++ P Sbjct: 2165 LLSQSLEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQL------TVMEPPHIE 2215 Query: 522 VEGQAVTLSCRSGL--------SPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSY 573 GQ LS G TP +W+ +G L +S DAG Y Sbjct: 2216 DSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLY 2275 Query: 574 HCRARDGHSASGPSSPAVLTV---LYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDP 630 C A A S + + PR P F L A + +L C V+++P Sbjct: 2276 TCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGL--------APGQLVLECSVEAEP 2327 Query: 631 PARLQLLHKDRVVA-----TSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685 ++ H+D +V T P G +++ + G Sbjct: 2328 APKITW-HRDGIVLQEDAHTQFPERGRF--------------------LQLQALSTADSG 2366 Query: 686 LYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANF-SW 744 Y C A NA G STS F + + S N T + +A G PA SW Sbjct: 2367 DYSCTARNAAG--STSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSW 2424 Query: 745 FRNGV-------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPD 797 ++ V + P ++ + PV DA Y C AG+ L VL PP Sbjct: 2425 RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDL-RVLEPPA 2483 Query: 798 RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEAN 857 + L + AL C P L+ + L L G ++ +N Sbjct: 2484 IAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL-----QQGAYRL-LPSN 2537 Query: 858 SLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQA------ 911 +L L G DS + C +N +G ++ R V V P + + Q Sbjct: 2538 ALLLTAP--GPQDSAQFECVVSNEVGEAH-------RLYQVTVHVPPTIADDQTDFTVTM 2588 Query: 912 ---VVLSCQVHTGVPEGTSYRWYRDGQPL-------QESTSATLRFAAITLTQAGAYHCQ 961 VVL+C TG+P T W + G L + S S L AG Y C Sbjct: 2589 MAPVVLTCH-STGIPAPT-VSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCS 2646 Query: 962 AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGD 1021 A+ + L V +P L +++ LL C P + Sbjct: 2647 ARNSAGVAHK---HVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG 2703 Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081 VA+ + P G +L I A ED G Y+C A N+ G A Sbjct: 2704 LNVATGVSTQVLPGG--------------QLRIAHASPEDAGNYLCIAKNSAGSAMGKTR 2749 Query: 1082 FDAQAVNV--QVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS------ 1133 Q V P + EG L C + +T W +DGQ A Sbjct: 2750 LVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNIT--WDKDGQPVSGAEGKFTIQP 2807 Query: 1134 ---IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAP--------RNLRLTYLL- 1181 + + N+ +DA +Y C R R + L +L P R+LRL L Sbjct: 2808 SGELLVKNLEGQDAGTYTCTA--ENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLW 2865 Query: 1182 ---ESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGF 1238 + G + TV+ RP + G A S D G Sbjct: 2866 LRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVS-------------REDSGT 2912 Query: 1239 YSCSARSPLGQANTSLELRLEGVRVILAPEAAV---PEGAPITVTCADPAAHAPTLYTWY 1295 Y C A + +G+ + ++ V+ + P G I + C P ++ W Sbjct: 2913 YVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIH-WI 2971 Query: 1296 HNG---------RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP 1346 +G LQ G SL+ R AG Y C A++ G + + L + AP Sbjct: 2972 KDGLPLRGSHLRHQLQNG---SLTIRRTERDDAGRYQCLAENEMGV-AKKVVILVLQSAP 3027 Query: 1347 QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVAR 1406 V R+ ++C EP + G+ L S + +L G+ Sbjct: 3028 VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGS------- 3080 Query: 1407 NALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQVEG 1444 L +++V GD TY C A NLLGS + L V G Sbjct: 3081 ----LWLENVETGDAGTYDCVAHNLLGSATARAFLVVRG 3115 Score = 144 bits (362), Expect = 1e-33 Identities = 356/1523 (23%), Positives = 529/1523 (34%), Gaps = 293/1523 (19%) Query: 250 RNILPGELVTLTCQVNSSYPAVSSIKWLK--------DGVRLQTKTGVLHLPQAAWSDAG 301 R I+ L C N+ P + W + D V + VL +P +AG Sbjct: 1478 REIVENNPAYLYCDTNAIPPP--DLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAG 1535 Query: 302 VYTCQAENGVGS--------LVSPPISL---HIFMAEVQVSPAGPILENQTVTLVCNT-P 349 Y+C+A N VG +++PP+ L + EV V+ + TV+L C Sbjct: 1536 RYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS------TVSLQCPALG 1589 Query: 350 NEAPSDLRYSWYKNHV---------LLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSER 400 N P+ SW +N + +LED L++ A AD Y C +N GS Sbjct: 1590 NPVPT---ISWLQNGLPFSPSPRLQVLEDGQ--VLQVSTAEVADAASYMCVAENQAGSAE 1644 Query: 401 SGPVSVVVNHPPLTPVL-----TAFLETQAGLVGILHCSVVSEPL---ATLVLSHGGHIL 452 ++ V PP L TA L + L +H E + LS G + Sbjct: 1645 K-LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVF 1703 Query: 453 ASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR 512 P + L++ +DSG Y C A N+ G + Sbjct: 1704 LL----------------PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLS----- 1742 Query: 513 LLISPAAE-----------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP----- 556 +L+ PA V G LSC + P P +WY +G L Sbjct: 1743 VLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTV--TWYKDGQPLVLAQRTQAL 1800 Query: 557 --GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGA 614 G L + A +D G Y C+ + A LTV PP T AG+ Sbjct: 1801 RGGQRLEIQEAQVSDKGLYSCKV--SNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGS 1858 Query: 615 GAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRV 674 +L C V P + L KDR+ S G S G R+ Sbjct: 1859 PL----VLTCDVSGVPAPTVTWL-KDRMPVESSAVHGVVSRGG---------------RL 1898 Query: 675 EIHNPLLEEEGLYLCEASNALGNAS----TSATFNGQATVLAIAPSHTLQEGTEANLTCN 730 ++ + G Y C A N A + + +A H + EG E L C Sbjct: 1899 QLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC- 1957 Query: 731 VSREAAGSPA-NFSWFRNGVLWAQ--GPL-------ETVTLLPVARTDAALYACRILTEA 780 EA G P + +W ++G Q GP ++ L + +DA Y C A Sbjct: 1958 ---EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPA 2014 Query: 781 G--AQLSTPVLLSVLYPPDRPKL---SALLDMGQGHMALFICTV-DSRPLALLALFHGEH 834 G A+L T ++VL PP + S L G + +C V S P+ + L G Sbjct: 2015 GEDARLHT---VNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDG-- 2069 Query: 835 LLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894 L L + HG + L + ++ L D+G + C A + G ++ + QV Sbjct: 2070 -LPLPLSQRTLLHG--------SGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV- 2119 Query: 895 GAWVQVSPSPELQE---------GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST---S 942 QV P E E G V L C+ GVP W +DG+PL + Sbjct: 2120 ----QVPPVLEPVEFQNDVVVVRGSLVELPCEAR-GVPLPL-VSWMKDGEPLLSQSLEQG 2173 Query: 943 ATLRFAAITLTQAGAYHCQA-----QAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP 997 +L+ A+ +G Y C A +A ++ P + S P ++LT P Sbjct: 2174 PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLT------P 2227 Query: 998 GRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGA 1057 G LLC P + H D + L+ + + A LR+ Sbjct: 2228 GAPMELLCDAQGTPQPNITW-HKDGQALTRLE------------NNSRATRVLRVR---- 2270 Query: 1058 MLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGAT-----VREGQLVNLTCLVWTT 1112 D G+Y C A + G S QA V P + GQLV L C V Sbjct: 2271 ---DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSV-EA 2325 Query: 1113 HPAQLTYTWYQDG-QQRLDAHS--------IPLPNVTVRDATSYRC----GVGPPGRAPR 1159 PA TW++DG + DAH+ + L ++ D+ Y C G A R Sbjct: 2326 EPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2384 Query: 1160 LSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGR--LLASSTA 1217 + + P + ++ Q AL+ C D PA L R L S Sbjct: 2385 VEIHTVPTIRSGPPAVNVSV------NQTALLPCQADG-VPAPLVSWRKDRVPLDPRSPR 2437 Query: 1218 ASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPI 1277 + L ++ +D G Y C A + G +LR +L P A P + + Sbjct: 2438 FEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR------VLEPPAIAPSPSNL 2491 Query: 1278 TVTCADPA-------AHAPTLYTWYHNGRWL----QEG-----PAASLSFLVATRAHAGA 1321 T+T PA L W+ +G+ L Q+G P+ +L + Sbjct: 2492 TLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQ 2551 Query: 1322 YSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMA--VIQCTVDSEPPAELAL 1379 + C + G QV + D MA V+ C P ++ Sbjct: 2552 FECVVSNEVGEAHR---LYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSW 2608 Query: 1380 SHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGR 1439 S G L A G+G+ AL + Q +P Y C+A+N G Sbjct: 2609 SKAGAQLG--------ARGSGYRVSPSGALEIG-QALPIHAGRYTCSARNSAGVAHKHVF 2659 Query: 1440 LQVEGARVVAEPGLDVPEGAA---LNLSCRLLGGPGPVGNSTFAWFWNDRRL------HA 1490 L V+ + VV +P V A + L C G P P T W + Sbjct: 2660 LTVQASPVV-KPLPSVVRAVAEEEVLLPCEASGIPRP----TITWQKEGLNVATGVSTQV 2714 Query: 1491 EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRG 1550 P L H + AG Y C+A+ G+A L V PP + + G Sbjct: 2715 LPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGK-TRLVVQVPPVIENGLPDLSTTEGSHA 2773 Query: 1551 ILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGE 1610 L C+ P ++T + V+ AE + S L ++ L D G Sbjct: 2774 FLPCKARGSPEPNITWDKDGQPVSG-------AEGKFTIQPSGELL---VKNLEGQDAGT 2823 Query: 1611 YICSASNVLGSASTSTYFGVRAL 1633 Y C+A N +G A + + L Sbjct: 2824 YTCTAENAVGRARRRVHLTILVL 2846 Score = 124 bits (311), Expect = 8e-28 Identities = 264/1141 (23%), Positives = 404/1141 (35%), Gaps = 168/1141 (14%) Query: 188 SQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSP 247 SQ+ G GH TL ++ I C + A LQV+ P +L Sbjct: 2075 SQRTLLHGSGH--TLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPP----VLEPV 2128 Query: 248 SGRN---ILPGELVTLTCQVNS-SYPAVSSIKWLKDGVRLQTKT----GVLHLPQAAWSD 299 +N ++ G LV L C+ P VS W+KDG L +++ L L D Sbjct: 2129 EFQNDVVVVRGSLVELPCEARGVPLPLVS---WMKDGEPLLSQSLEQGPSLQLEAVGAGD 2185 Query: 300 AGVYTCQAENGVG--------SLVSPPISLHIFMA----EVQVSPAGPILENQTVTLVCN 347 +G Y+C A + G +++ PP HI + E+ ++P P+ L+C+ Sbjct: 2186 SGTYSCVAVSEAGEARRHFQLTVMEPP---HIEDSGQPTELSLTPGAPM------ELLCD 2236 Query: 348 TPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGS-ERSGPVSV 406 ++ +W+K+ L +++ + D G Y C ++ G+ E+S V V Sbjct: 2237 AQGTPQPNI--TWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRV 2294 Query: 407 VVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466 + P F+ A +L CSV +EP + G +L + Sbjct: 2295 QAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAH--------- 2345 Query: 467 GTSGPNSLR-LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLIS--PAAEVVE 523 T P R L+++ L DSG+Y C+A N+ G+ + + + S PA V Sbjct: 2346 -TQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSV 2404 Query: 524 GQAVTLSCRSGLSPTPDARFSWYLNGALLHEG-------PGSSLLLPAASSTDAGSYHCR 576 Q L C++ P P SW + L P SL + + DAG Y C Sbjct: 2405 NQTALLPCQADGVPAP--LVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCL 2462 Query: 577 ARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQL 636 A +SA L VL PP + L L A LL C P + Sbjct: 2463 A--SNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPA-----LLPCEASGSPKPLVVW 2515 Query: 637 LHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG 696 + + L G ++ + LL + P ++ + C SN +G Sbjct: 2516 WKDGQKLDFRLQQGA-----------YRLLPSNALL---LTAPGPQDSAQFECVVSNEVG 2561 Query: 697 NAST--SATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNGV---- 749 A T + T+ T+ LTC+ + G PA SW + G Sbjct: 2562 EAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCH----STGIPAPTVSWSKAGAQLGA 2617 Query: 750 ------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSA 803 + G LE LP+ A Y C AG V L+V P L + Sbjct: 2618 RGSGYRVSPSGALEIGQALPI---HAGRYTCSARNSAGVA-HKHVFLTVQASPVVKPLPS 2673 Query: 804 LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863 ++ L C P + +AT + QV G+ L + Sbjct: 2674 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ-----------LRI 2722 Query: 864 RELGLGDSGSYRCEATNVLGSS--NTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTG 921 D+G+Y C A N GS+ T L QV P EG L C+ G Sbjct: 2723 AHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKAR-G 2781 Query: 922 VPEGTSYRWYRDGQPLQEST-------SATLRFAAITLTQAGAYHCQAQAPGSATTSLAA 974 PE + W +DGQP+ + S L + AG Y C A+ +A Sbjct: 2782 SPE-PNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAE---NAVGRARR 2837 Query: 975 PISLHVSYAPRHVTLTTLMDTGPGRLG---LLLCRVDSDPPAQLRLLHGDRLVASTLQGV 1031 + L + P TTL RLG L C P ++ DR V +GV Sbjct: 2838 RVHLTILVLP---VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT---EGV 2891 Query: 1032 GGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF---DAQAVN 1088 +G S AV+ ED G Y+C A N +G+ A + +A + Sbjct: 2892 SEQDGGSTLQRAAVSR------------EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQ 2939 Query: 1089 VQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH---SIPLPNVTVR--- 1142 + + G + L C+V + W +DG +H + ++T+R Sbjct: 2940 GEAFSYLVEPVGGSIQLDCVVRGDPVPDIH--WIKDGLPLRGSHLRHQLQNGSLTIRRTE 2997 Query: 1143 --DATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRP 1199 DA Y+C G A ++ + L + AP + G + C P Sbjct: 2998 RDDAGRYQCLAENEMGVAKKV---VILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEP 3054 Query: 1200 PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE 1259 + AG+ L +S L L + D G Y C A + LG A L + Sbjct: 3055 TPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3114 Query: 1260 G 1260 G Sbjct: 3115 G 3115 Score = 75.9 bits (185), Expect = 3e-13 Identities = 210/931 (22%), Positives = 327/931 (35%), Gaps = 140/931 (15%) Query: 768 DAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALL 827 D+ LY+CR +AG LL VL PP ++L G L + D Sbjct: 98 DSGLYSCRAENQAGTAQRDFHLL-VLTPP------SVLGAGAAQEVLGLAGADVELQCWT 150 Query: 828 ALFHGEHLLATS-LGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN 886 + + T P +P Q + + L++ +G D G Y+C A + G Sbjct: 151 SGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSPAGQQA 208 Query: 887 TSLFFQVRGA---W-VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTS 942 +V W + + E V L C+ GVP + W++DG L ST Sbjct: 209 RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEAR-GVPT-PNITWFKDGALLPTSTK 266 Query: 943 AT-------LRFAAITLTQAGAYHCQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMD 994 L+ + AG Y C+A A G+A + + Y P + Sbjct: 267 VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-----YVPPTIE------ 315 Query: 995 TGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEI 1054 G G ++ V P A + G + G P S + + LRLE Sbjct: 316 -GAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLES 374 Query: 1055 HGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHP 1114 G G+Y C AS+ G+A +V VQV P V EG L +T +V P Sbjct: 375 PGEA--SSGLYSCVASSPAGEAVLQ-----YSVEVQVPPQLLVAEG-LGQVTTIVG--QP 424 Query: 1115 AQL----------TYTWYQDG---------QQRLDAHSIPLPNVTVRDATSYRCGVGPPG 1155 +L T W Q+G Q ++ + +V + + + C Sbjct: 425 LELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 484 Query: 1156 RAPRLSRPITLDVLYAPRNLRLT-----YLLESHGGQLALVLCTVDS------RPPAQLA 1204 +++ +AP L + + E H A V +PP Sbjct: 485 GTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEG 544 Query: 1205 LSHAGRLLASSTAASVPNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVR 1262 G L T V +L L++ RDEG Y+C+A + G++ + L+ Sbjct: 545 WCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALK----- 599 Query: 1263 VILAPEA-------AVPEGAPITVTCADPAAHAPTLYTWYHNGR----WLQEGPAASLSF 1311 V++ P AV E A +T+ C P + +W+ + W+ G S+ Sbjct: 600 VLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDV-SWFKGHQPVSSWM--GVTVSVDG 656 Query: 1312 LV-----ATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV-I 1365 V A + AG+Y C A + G+ R L+V P+ + S + V + Sbjct: 657 RVLRIEQAQLSDAGSYRCVASNVAGSTELR-YGLRVNVPPRITLPPSLPGPVLVNTPVRL 715 Query: 1366 QCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYV 1424 C P L DG ++ + GT +QV L + A D Y Sbjct: 716 TCNATGAPSPTLMWLKDGNPVSPA--------GTPGLQVFPGGRVLTLASARASDSGRYS 767 Query: 1425 CTAQNLLGSISTIGRLQVEGARVVA--EPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWF 1482 C A + +G LQV + E + V ++ L C+ P PV +W+ Sbjct: 768 CVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV----LSWW 823 Query: 1483 WNDRRLHAEPVPTL----AFTHVARAQ---AGMYHCLAELPTGAAA---SAPVMLRVLYP 1532 + R L P L A V RA AG Y C A G + + V + ++P Sbjct: 824 KDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFP 883 Query: 1533 PKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLAS 1592 + + E G L C P ++ QP HV A Sbjct: 884 LRESHTLTVRE---GHPTRLSCECRGVPFPKISWR------KDGQPLPGEGAGLQHVSAV 934 Query: 1593 PNALRVDIEALRPSDQGEYICSASNVLGSAS 1623 L + L + +G Y C SNV+G++S Sbjct: 935 GRLLYLGQAQL--AQEGTYTCECSNVVGNSS 963 Score = 73.2 bits (178), Expect = 2e-12 Identities = 153/634 (24%), Positives = 215/634 (33%), Gaps = 104/634 (16%) Query: 1061 DEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVRE------GQLVNLTCLVWTTHP 1114 D G+Y C A N G +A DF + GA + G V L C WT+ Sbjct: 98 DSGLYSCRAENQAG--TAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQC--WTSGV 153 Query: 1115 AQLTYTWYQDGQQRL----------DAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPI 1164 W +D Q L D + + V D Y+C P A + +R Sbjct: 154 PTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP--AGQQARDF 211 Query: 1165 TLDV-----LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAAS 1219 L V ++ ++E H L +LC P + G LL +ST Sbjct: 212 QLRVHAPPTIWGSNETGEVAVMEDH---LVQLLCEARGVPTPNITWFKDGALLPTSTKVV 268 Query: 1220 VPNTLR-LELRGPQPRDEGFYSCSARSPLGQANTSLELRL--------EGVRVILAPEAA 1270 R L+L Q D G Y+C A + +G A + L + G R + A Sbjct: 269 YTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA 328 Query: 1271 VPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVAT-------RAHAGAYS 1323 G P+ + C +PTL +W+H G + E + L + A +G YS Sbjct: 329 ---GRPVALECVARGHPSPTL-SWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYS 384 Query: 1324 CQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDG 1383 C A G + +++V PQ V Q T P EL G Sbjct: 385 CVASSPAG-EAVLQYSVEVQVPPQLLVAEGLG----------QVTTIVGQPLELPCQASG 433 Query: 1384 KVLATSSGVHS--LASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRL 1440 + T + + A VQVA L + V + C A N G+ + Sbjct: 434 SPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEV 493 Query: 1441 QVEGARVVAEPG-LDVPEG-------------AALNLSCRLLGGPGPVGNSTFAWFWNDR 1486 V G PG L+VP G AA + G P W + Sbjct: 494 SVHGEWA---PGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWC-SPG 549 Query: 1487 RLHAEPV---------PTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPT 1537 L EP P L V G+Y C A G + V L+VL PP Sbjct: 550 SLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGES-KREVALKVLVPPNIEP 608 Query: 1538 MMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALR 1597 V L+C P ++ G + V+S + V S + Sbjct: 609 GPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSS----------WMGVTVSVDGRV 658 Query: 1598 VDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631 + IE + SD G Y C ASNV G ST +G+R Sbjct: 659 LRIEQAQLSDAGSYRCVASNVAG--STELRYGLR 690 Score = 58.9 bits (141), Expect = 4e-08 Identities = 98/436 (22%), Positives = 148/436 (33%), Gaps = 72/436 (16%) Query: 1232 QPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVP----EGAPITVTCADPAAH 1287 Q D G YSC A + G A L + +L AA GA + + C Sbjct: 95 QEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVP 154 Query: 1288 APTLYTWYHNGRWLQEGPAASLS----FLVATRAHAG---AYSCQAQDAQGTRSSRPAAL 1340 P + L GP + L T +H G Y C A G + +R L Sbjct: 155 TPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAG-QQARDFQL 213 Query: 1341 QVLYAPQDAVLSSFRDSRARSMAVIQ-------CTVDSEPPAELALSHDGKVLATSSGVH 1393 +V P + + + +AV++ C P + DG +L TS+ V Sbjct: 214 RVHAPP-----TIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVV 268 Query: 1394 SLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPG- 1452 G +Q+ R Q AG Y C A N +G+ RL V + G Sbjct: 269 YTRGGR-QLQLGR------AQSSDAG--VYTCKASNAVGAAEKATRLDVYVPPTIEGAGG 319 Query: 1453 ----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFW--------NDRRLHAEPVPTLAFTH 1500 + G + L C G P P T +W N+ RL + L Sbjct: 320 RPYVVKAVAGRPVALECVARGHPSP----TLSWHHEGLPVAESNESRLETDG-SVLRLES 374 Query: 1501 VARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI------LDC 1554 A +G+Y C+A P G A +L+ + P ++ E G + I L C Sbjct: 375 PGEASSGLYSCVASSPAGEA-----VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPC 429 Query: 1555 RVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICS 1614 + P+ ++ G PAE V + + I+ + G + C Sbjct: 430 QASGSPVPTIQW----------LQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQ 479 Query: 1615 ASNVLGSASTSTYFGV 1630 A+N G+A V Sbjct: 480 ATNEAGTAGAEVEVSV 495 Score = 50.4 bits (119), Expect = 1e-05 Identities = 90/346 (26%), Positives = 129/346 (37%), Gaps = 54/346 (15%) Query: 1299 RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSR 1358 R L EG SL F +G YSC+A++ GT + R L VL P +VL + Sbjct: 81 RLLDEGQ--SLHFPRIQEGDSGLYSCRAENQAGT-AQRDFHLLVLTPP--SVLGAGAAQE 135 Query: 1359 ARSMA----VIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQ 1414 +A +QC P ++ + D + + G H+QV + L++ Sbjct: 136 VLGLAGADVELQCWTSGVPTPQVEWTKDRQ---------PVLPGGPHLQVQEDGQVLRIT 186 Query: 1415 DVPAGDD-TYVCTAQNLLGSISTIGRLQVEGARVV---AEPG-LDVPEGAALNLSCRLLG 1469 GD+ Y C A + G + +L+V + E G + V E + L C G Sbjct: 187 GSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARG 246 Query: 1470 GPGPVGNSTFAWFWNDRRLHAEPVPT-LAFT------HVARAQ---AGMYHCLAELPTGA 1519 P P WF + L P T + +T + RAQ AG+Y C A GA Sbjct: 247 VPTP----NITWFKDGALL---PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA 299 Query: 1520 AASAPVMLRVLYPPK---TPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASS 1576 A A L V PP V+ G L+C P +L+ H VA S Sbjct: 300 AEKA-TRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAES 358 Query: 1577 QPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622 + + L SP + G Y C AS+ G A Sbjct: 359 NESRLETDGSVLRLESPG----------EASSGLYSCVASSPAGEA 394 Score = 47.4 bits (111), Expect = 1e-04 Identities = 82/328 (25%), Positives = 119/328 (36%), Gaps = 37/328 (11%) Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159 LL+K+L+ +D+G+Y E + V T++ + P T+ L G + Sbjct: 2811 LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL---PVFTTLPGDRSLRLGDRLWLR 2867 Query: 160 CSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQL 219 C+ R+ W D R VT E G L+ A+S +D G + C Sbjct: 2868 CAARG---SPTPRIGWTVND--RPVTEGVS--EQDGGSTLQ--RAAVSREDSGTYV-CWA 2917 Query: 220 SVANHRAQSEIHLQVKYAP----KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIK 275 R Q+ + VK AP + L+ P G +I L C V V I Sbjct: 2918 ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSI------QLDCVVRGD--PVPDIH 2969 Query: 276 WLKDGVRL-------QTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEV 328 W+KDG+ L Q + G L + + DAG Y C AEN +G I + Sbjct: 2970 WIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVF 3029 Query: 329 QVSPAG-PILENQTVTLVCNTPNEAPSDLRYSWYKNHVL----LEDAHSHTLRLHLATRA 383 QV P + V L C E + + + L +L L Sbjct: 3030 QVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETG 3089 Query: 384 DTGFYFCEVQNVHGSERSGPVSVVVNHP 411 D G Y C N+ GS + VV P Sbjct: 3090 DAGTYDCVAHNLLGSATARAFLVVRGEP 3117 Score = 37.4 bits (85), Expect = 0.13 Identities = 69/298 (23%), Positives = 102/298 (34%), Gaps = 59/298 (19%) Query: 1365 IQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNAL-----RLQVQDVPAG 1419 ++C + P E+ D +++ G G QV + L L + G Sbjct: 38 LECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEG 97 Query: 1420 DD-TYVCTAQNLLGSISTIGRL------QVEGARVVAEP-GLDVPEGAALNLSCRLLGGP 1471 D Y C A+N G+ L V GA E GL GA + L C G P Sbjct: 98 DSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGL---AGADVELQCWTSGVP 154 Query: 1472 GPVGNSTFAWFWNDRRLHAEP------------VPTLAFTHVARAQAGMYHCLAELPTGA 1519 P W R P V + +HV G Y C+A P G Sbjct: 155 TPQVE------WTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSPAGQ 206 Query: 1520 AASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILD-------CRVDSEPLASLTLHLGSRL 1572 A LRV PP ++ E G +++ C P ++T L Sbjct: 207 QAR-DFQLRVHAPPT-----IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGAL 260 Query: 1573 VASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGV 1630 + +S V+ + ++ + + SD G Y C ASN +G+A +T V Sbjct: 261 LPTSTK----------VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 308 >gi|110349719 titin isoform N2-A [Homo sapiens] Length = 33423 Score = 201 bits (511), Expect = 5e-51 Identities = 332/1499 (22%), Positives = 559/1499 (37%), Gaps = 228/1499 (15%) Query: 255 GELVTLTCQVNSSYPAVSSIKWLKDGVRL--------QTKTGV--LHLPQAAWSDAGVYT 304 GE TL C+V+ + P + I W K+ +L Q K V L + + SD G Y+ Sbjct: 7034 GEPATLQCKVDGT-PEIR-ISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYS 7091 Query: 305 CQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQT----------VTLVCNTPNEAPS 354 C+A+N VG++ S + + ++ P + V C P Sbjct: 7092 CKADNSVGAVASSAVLV------IKARKLPPFFARKLKDVHETLGFPVAFECRINGSEP- 7144 Query: 355 DLRYSWYKNHVLLED--------AHS-HTLRLHLATRADTGFYFCEVQNVHGSERSGPVS 405 L+ SWYK+ VLL+D H+ TL++ ++ G Y C N G+ S Sbjct: 7145 -LQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKL 7203 Query: 406 VVVNH--PPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP 463 ++ H PP + ++ G G C V + A + + Sbjct: 7204 ILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITW-------AKDNREIRPGG 7256 Query: 464 RFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLIS---PAAE 520 + T N+ L + + + D+G+Y C A+N G + + I P+ Sbjct: 7257 NYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRI 7316 Query: 521 VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPG---------SSLLLPAASSTDAG 571 V + + C+ G SP + + WY + + E + L + S D+G Sbjct: 7317 VKQDEFTRYECKIGGSP--EIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSG 7374 Query: 572 SYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPP 631 Y C A H+A+G +S + T L P F + GA L C + PP Sbjct: 7375 DYTCEA---HNAAGSASSS--TSLKVKEPPIFRKKPHPIETLKGADVH--LECELQGTPP 7427 Query: 632 ARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEA 691 + +KD+ L SG + K+ L + I N + G Y C+A Sbjct: 7428 FHVSW-YKDK---RELRSG----------KKYKIMSENFLTSIHILNVDAADIGEYQCKA 7473 Query: 692 SNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFRN---- 747 +N +G+ + + +A + + + + E A P + WF++ Sbjct: 7474 TNDVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGA-EPISVVWFKDKGEI 7532 Query: 748 ----GVLWAQGPLETVTLLPVARTD---AALYACRILTEAGAQLSTPVLLSVLYPPDRPK 800 +W E + L +R + A Y C+I +AG Q LSVL P + Sbjct: 7533 VRESDNIWISYS-ENIATLQFSRVEPANAGKYTCQIKNDAGMQ-ECFATLSVLEPATIVE 7590 Query: 801 LSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLK 860 + + G CTV P F G ++ S +++ Sbjct: 7591 KPESIKVTTGDTCTLECTVAGTPELSTKWFKD--------GKELTSDNKYKISFFNKVSG 7642 Query: 861 LEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE-----GQAVVLS 915 L++ + DSG Y E N +G + + QV V S + +L+E G +VV+ Sbjct: 7643 LKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVME 7702 Query: 916 CQVHTGVPEGTSYRWYRDGQPLQES----TSATLRFAAITL-----TQAGAYHCQAQAPG 966 C+V+ P S W+ +G + T+ T A+T+ + +G Y C A Sbjct: 7703 CKVYGSPPISVS--WFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNM- 7759 Query: 967 SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVAS 1026 + + +AP++ V P V MD G V PP + G + Sbjct: 7760 AGSDECSAPLT--VREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVP 7817 Query: 1027 TLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF--DA 1084 R +V++ + LE+ G Y C SN G+AS + A Sbjct: 7818 -----------GDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKA 7866 Query: 1085 QAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDG-----QQRLDAHS------ 1133 A V+ ++ +G+ + L T P ++ TW ++G QR + + Sbjct: 7867 PAKFVKRLNDYSIEKGKPLILEGTFTGTPP--ISVTWKKNGINVTPSQRCNITTTEKSAI 7924 Query: 1134 IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLC 1193 + +P+ TV DA Y C + S I +L P ++ ++ G A + C Sbjct: 7925 LEIPSSTVEDAGQYNCYIENASGKDSCSAQIL--ILEPPYFVKQLEPVKVSVGDSASLQC 7982 Query: 1194 TVDSRPPAQLALSHAGRLLASSTAASVP---NTLRLELRGPQPRDEGFYSCSARSPLGQA 1250 + P ++ L +T + N L D G Y C A + +G+ Sbjct: 7983 QLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEV 8042 Query: 1251 NTSLELRLEGVRVILAPEAAVPE-----GAPITVTCADPAAHAPTLYTWYHNGRWLQEGP 1305 + S L ++ ++ + + + G P+ CA + P +WY +G+ L++ P Sbjct: 8043 SASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSE-PISVSWYKDGKPLKDSP 8101 Query: 1306 AASLSFLVAT---------RAHAGAYSCQAQDAQGTRSS----------RPAALQVLYAP 1346 SFL T R+ AG YSC A + G+ SS P + AP Sbjct: 8102 NVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAP 8161 Query: 1347 QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVAR 1406 DAV+ D +C V P +++ + D + + + G + Sbjct: 8162 VDAVVGESAD--------FECHVTGTQPIKVSWAKDSREIRSG--------GKYQISYLE 8205 Query: 1407 NALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQVEGARVVAE------PGLDVPEGA 1459 N+ L V V GD Y C A N +G S +L ++ + ++ EG Sbjct: 8206 NSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGN 8265 Query: 1460 ALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTH------VARA---QAGMYH 1510 + L R+ G P+ T AW+ N+ + + F + V +A AG+Y Sbjct: 8266 SFKLEGRVAGSQ-PI---TVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYT 8321 Query: 1511 CLAELPTGAA--ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVD-SEPLASLTLH 1567 C G+A S+ V+ PP + V G L C V SEP+ L Sbjct: 8322 CKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLK 8381 Query: 1568 LGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTST 1626 G + P++ AS A+ +++ + +D G+Y+C ASNV GS +T + Sbjct: 8382 AGREI--------KPSDRCSFSFASGTAV-LELRDVAKADSGDYVCKASNVAGSDTTKS 8431 Score = 186 bits (472), Expect = 2e-46 Identities = 357/1650 (21%), Positives = 601/1650 (36%), Gaps = 239/1650 (14%) Query: 102 LKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCS 161 + D++ EDSGSY+ +++V SD T + + E P P +++ GT C Sbjct: 3797 ITDVKVEDSGSYSCE-AVNDVG--SDSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCE 3853 Query: 162 TPYVCLQEQVRLQW-QGQDPARSVTFNSQKFEPTGVGHLETLHM-AMSWQDHGRILRCQL 219 V + W + + RS S+K+ L L + + + D G + Sbjct: 3854 ---VSGTGPFEISWFKDKKQIRS----SKKYRLFSQKSLVCLEIFSFNSADVGEY---EC 3903 Query: 220 SVANHRAQS---EIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW 276 VAN + HL +K P VK + L G+ VTL V S P S+ W Sbjct: 3904 VVANEVGKCGCMATHL-LKEPPTFVKKV---DDLIALGGQTVTLQAAVRGSEPI--SVTW 3957 Query: 277 LK-------DG-VRLQTKTGV--LHLPQAAWSDAGVYTCQAENGVGS-------LVSPPI 319 +K DG +++ GV L +P S G YTC AEN GS +V P Sbjct: 3958 MKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPA 4017 Query: 320 SLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHT----- 374 + +QV+ P TV TP +L+ WYK+ L + + Sbjct: 4018 KIIERAELIQVTAGDPATLEYTVA---GTP-----ELKPKWYKDGRPLVASKKYRISFKN 4069 Query: 375 ----LRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVG- 429 L+ + A D+G Y E+ N GS V++ + P T L +V Sbjct: 4070 NVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRD-IAPFFTKPLRNVDSVVNG 4128 Query: 430 --ILHCSVV-SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDS 486 L C + S P+ G I AS D GT+ LEI ++ D+ Sbjct: 4129 TCRLDCKIAGSLPMRVSWFKDGKEIAAS---DRYRIAFVEGTAS-----LEIIRVDMNDA 4180 Query: 487 GEYKCSATNSLGNATST--LDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFS 544 G + C ATNS+G+ S+ L + + + +V+ G AV L +S + Sbjct: 4181 GNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCL--KSTFQGSTPLTIR 4238 Query: 545 WYLNGALLHEGPG---------SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVL 595 W+ L G SSL L ++D+G+Y C+ + A G A L V Sbjct: 4239 WFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKV--SNVAGGVECSANLFVK 4296 Query: 596 YPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCST 655 P TF +L+ + G L C+V PP ++ DR + S Sbjct: 4297 EP---ATFVEKLE-PSQLLKKGDATQLACKVTGTPPIKITWFANDREIKES--------- 4343 Query: 656 CGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATF---NGQATVLA 712 RM ++ +LR + + +E+ G Y+CEA N G+ S+ Sbjct: 4344 ---SKHRMSFVESTAVLR--LTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKE 4398 Query: 713 IAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNGVL---------WAQGPLETVTLL 762 P L+E L E AG+P +WF++ + + Q L ++ +L Sbjct: 4399 FKPIEVLKEYDVMLLA-----EVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQIL 4453 Query: 763 PVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTV-DS 821 DA Y CR+ E G+ + + +++ PP K +G A F T+ S Sbjct: 4454 KFVAADAGEYQCRVTNEVGSSICS-ARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGS 4512 Query: 822 RPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNV 881 P+ + L + ++ + E N L + + + G Y C+A N Sbjct: 4513 LPITVTWLKDSD---------EITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKND 4563 Query: 882 LGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQ--- 938 G S V+ + + Q + QV + + +W++DGQ L Sbjct: 4564 AGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGS 4623 Query: 939 ------ESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTL 992 T + L+ + +G Y + Q ++ A L + P Sbjct: 4624 KYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKK 4683 Query: 993 MDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRL 1052 MD+ G L C V P ++ D+ ++ +S + + NT L Sbjct: 4684 MDSIKGSFIDLECIVAGSHPISIQWFKDDQEIS-----------ASEKYKFSFHDNTAFL 4732 Query: 1053 EIHGAMLEDEGVYICEASNTLG--QASASADFDAQAVNVQVWPGATVREGQLVNLTCLVW 1110 EI D G Y C A+N G Q S V+ V V L LV Sbjct: 4733 EISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVG 4792 Query: 1111 TTHPAQLTYTWYQDGQQRLD-----------AHSIPLPNVTVRDATSYRCGVGPPGRAPR 1159 T P +T W++D ++ + S+ L D+ +Y C + Sbjct: 4793 GTAP--MTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLS--NDVGT 4848 Query: 1160 LSRPITLDVLYAPRNLRL-TYLLESHGGQLALVLCTVDSRPPAQLALSHAGR---LLASS 1215 + TL V P+ ++ + +L GQ C + P +++ G + Sbjct: 4849 ATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKH 4908 Query: 1216 TAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGA 1275 + + ++ G + + G Y C AR+ G A+ S+EL+++ P + E Sbjct: 4909 GISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVK------EPPTFIRELK 4962 Query: 1276 PITVTC-------ADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVAT---------RAHA 1319 P+ V + P TW N R ++ +L+ V+ + Sbjct: 4963 PVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDT 5022 Query: 1320 GAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRA--RSMAVIQCTVDSEPPAEL 1377 G Y C + G+ S + +V + + ++ +S A Q TV PP + Sbjct: 5023 GEYQCIVSNEGGSCS---CSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISI 5079 Query: 1378 ALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAG-DDTYVCTAQNLLGSIST 1436 D ++L V ++ + LQ++ V G Y C A+N G Sbjct: 5080 TWLKDDQILDEDDNV--------YISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERC 5131 Query: 1437 IGRLQVEGARVVAE--PGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVP 1494 L V+ + E +DV E + L C + G P W + +++ Sbjct: 5132 YAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTP----ELKVKWLKDGKQIVPSRYF 5187 Query: 1495 TLAFTH---------VARAQAGMYHCLAELPTGAAASAPVMLRVL---YPPKTPTMMVFV 1542 +++F + V + +G Y E G ++S LRVL PP + + Sbjct: 5188 SMSFENNVASFRIQSVMKQDSGQYTFKVENDFG-SSSCDAYLRVLDQNIPPSFTKKLTKM 5246 Query: 1543 EPEGGLRGILDCRVD-SEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIE 1601 + G ++C+V S P+++ G + S++ ++ ++ +++ Sbjct: 5247 DKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAK---------YRLVCHERSVSLEVN 5297 Query: 1602 ALRPSDQGEYICSASNVLGSASTSTYFGVR 1631 L D Y C SNV G + S V+ Sbjct: 5298 NLELEDTANYTCKVSNVAGDDACSGILTVK 5327 Score = 186 bits (472), Expect = 2e-46 Identities = 370/1748 (21%), Positives = 630/1748 (36%), Gaps = 274/1748 (15%) Query: 27 QDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEARFRGR 86 +DV + G+ +++ C S A + V W+ D + ++VS PK + Sbjct: 6748 KDVNAILGASVVLECRVSGSAPISVG------WFQDGN---EIVS---GPKC-------Q 6788 Query: 87 TEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIAS 146 + F N VC L L L+P D+G Y ++ SD ++TV E P Sbjct: 6789 SSFSEN----VCTLNLSLLEPSDTGIYTC---VAANVAGSDECSAVLTVQEPPSFEQTPD 6841 Query: 147 PVELLEGTEVDFNCSTPYVCLQEQVRLQW----QGQDPARSVTFNSQKFEPTGVGHLETL 202 VE+L G + F T + +++W + P S + + F V LE Sbjct: 6842 SVEVLPGMSLTF---TSVIRGTPPFKVKWFKGSRELVPGESCNISLEDF----VTELELF 6894 Query: 203 HMA-MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLT 261 + + D+ C ++ A HL VK VK L S + G + L Sbjct: 6895 EVQPLESGDYS----CLVTNDAGSASCTTHLFVKEPATFVKRLADFS---VETGSPIVLE 6947 Query: 262 CQVNSSYPAVSSIKWLKD----------GVRLQTKTGVLHLPQAAWSDAGVYTCQAENGV 311 + P S+ W+KD + + K+ +L + ++ D Y+C EN Sbjct: 6948 ATYTGTPPI--SVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEA 7005 Query: 312 G--------SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKN 363 G S++ PP F+ ++ A + + TL C + ++R SWYK Sbjct: 7006 GQDICEALVSVLEPPY----FIEPLEHVEA---VIGEPATLQCKV--DGTPEIRISWYKE 7056 Query: 364 HVLLEDAHSHTLR---------LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNH--PP 412 H L A ++ ++ ++ +D G Y C+ N G+ S V V+ PP Sbjct: 7057 HTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLPP 7116 Query: 413 LTPVLTAFLETQAGLVGILHCSVV-SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGP 471 + G C + SEPL G D++ F Sbjct: 7117 FFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDG----VLLKDDANLQTSFVH---- 7168 Query: 472 NSLRLEIRDLEETDSGEYKCSATNSLGNATST----LDFHANAARLLISPAA-EVVEGQA 526 N L+I +++ G+Y CSA+N LG A+S+ L H + P + ++ G++ Sbjct: 7169 NVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGES 7228 Query: 527 VTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASST---------DAGSYHCRA 577 T C ++ T + +W + + G + L ++T DAG Y C A Sbjct: 7229 GTFKCH--VTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYA 7286 Query: 578 RDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLL 637 + A S A L V PPR F +L+ C++ P ++ L Sbjct: 7287 --SNIAGKDSCSAQLGVQEPPR---FIKKLEPSRI-VKQDEFTRYECKIGGSPEIKV-LW 7339 Query: 638 HKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGN 697 +KD S + +++ ++ +E+HN +E+ G Y CEA NA G+ Sbjct: 7340 YKDETEIQE-------------SSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGS 7386 Query: 698 ASTSATFNGQATVLAIAPSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRNG------- 748 AS+S + + + H ++ +G + +L C + P + SW+++ Sbjct: 7387 ASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQ---GTPPFHVSWYKDKRELRSGK 7443 Query: 749 --VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLD 806 + ++ L ++ +L V D Y C+ + G+ + P KLS + Sbjct: 7444 KYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDIST 7503 Query: 807 MGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVREL 866 + + L + P++++ G V N L+ + Sbjct: 7504 VVGKEVQLQTTIEGAEPISVVWF--------KDKGEIVRESDNIWISYSENIATLQFSRV 7555 Query: 867 GLGDSGSYRCEATNVLGSSN--TSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPE 924 ++G Y C+ N G +L V+ S ++ G L C V G PE Sbjct: 7556 EPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTV-AGTPE 7614 Query: 925 GTSYRWYRDGQPLQESTS---------ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAP 975 S +W++DG+ L + L+ + + +G Y + Q P + A Sbjct: 7615 -LSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTA-- 7671 Query: 976 ISLHVSYAPRHVTLTTLMDTGPGRLG---LLLCRVDSDPPAQLRLLHGDRLVASTLQGVG 1032 SL VS + T + G G ++ C+V PP + H G Sbjct: 7672 -SLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFH-----------EG 7719 Query: 1033 GPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVN--VQ 1090 S + + NT L ++ D G Y C A+N G SA + VQ Sbjct: 7720 NEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQ 7779 Query: 1091 VWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL-----------DAHSIPLPNV 1139 V G V T +V T P + +W++ + + + L +V Sbjct: 7780 KPDPMDVLTGTNVTFTSIVKGTPP--FSVSWFKGSSELVPGDRCNVSLEDSVAELELFDV 7837 Query: 1140 TVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRP 1199 + Y C V A + S L + + ++ G+ ++ T P Sbjct: 7838 DTSQSGEYTCIVS--NEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTP 7895 Query: 1200 PAQLALSHAGRLLASSTAASVPNTLR---LELRGPQPRDEGFYSCSARSPLGQANTSLEL 1256 P + G + S ++ T + LE+ D G Y+C + G+ + S ++ Sbjct: 7896 PISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQI 7955 Query: 1257 RLEGVRVILAPEAAVPEGAPITVTCADPA------AHAPTL-YTWYHNGRWLQ------- 1302 +IL P V + P+ V+ D A A P + +WY L+ Sbjct: 7956 ------LILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKM 8009 Query: 1303 --EGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSF----RD 1356 A+L F +G Y C+A+++ G S A L + + SF RD Sbjct: 8010 HFRNNVATLVFNQVDINDSGEYICKAENSVGEVS----ASTFLTVQEQKLPPSFSRQLRD 8065 Query: 1357 --SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVH-SLASGTGHVQVARNALRLQV 1413 V C + P ++ DGK L S V S T + + + L Sbjct: 8066 VQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAG 8125 Query: 1414 QDVPAGDDTYVCTAQNLLGSISTIGRL-QVEGARV----VAEPGLDVPEGAALNLSCRLL 1468 Q Y CTA N +GS S+ RL EG + +D G + + C + Sbjct: 8126 Q--------YSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVT 8177 Query: 1469 GGPGPVGNSTFAWFWNDRRL---------HAEPVPTLAFTHVARAQAGMYHCLAELPTG- 1518 G P+ +W + R + + E L V + +G Y C A G Sbjct: 8178 -GTQPI---KVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGK 8233 Query: 1519 --AAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRV-DSEPLASLTLHLGSRLVAS 1575 A + R++ P T + VE G L+ RV S+P+ + + Sbjct: 8234 DSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPT 8293 Query: 1576 SQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRALHR 1635 S + + N L + + +D G Y C SN GSA ++ ++ + Sbjct: 8294 S---------NCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKK 8344 Query: 1636 LHQFQQLL 1643 F Q L Sbjct: 8345 PPVFDQHL 8352 Score = 183 bits (464), Expect = 1e-45 Identities = 362/1735 (20%), Positives = 619/1735 (35%), Gaps = 234/1735 (13%) Query: 26 PQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEARFRG 85 P V +KGS +++ C S EV +W D ++QV R Sbjct: 6464 PSPVGALKGSDVILQCEISGTPPFEV------VWVKD---RKQV--------------RN 6500 Query: 86 RTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIA 145 +F +H +L + +L+ D G Y+ + +EV SD V E PR Sbjct: 6501 SKKFKITSKHFDTSLHILNLEASDVGEYHCK-ATNEVG--SDTCSCSVKFKEPPRFVKKL 6557 Query: 146 SPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMA 205 S L G V+ V L+ +G+ V S+ + + ++ TL + Sbjct: 6558 SDTSTLIGDAVELRAIVEGFQPISVVWLKDRGE-----VIRESENTRISFIDNIATLQLG 6612 Query: 206 MSWQDHGRILRCQL-SVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQV 264 + CQ+ + A R S + ++ A +I+ P + G L C V Sbjct: 6613 SPEASNSGKYICQIKNDAGMRECSAVLTVLEPA----RIIEKPEPMTVTTGNPFALECVV 6668 Query: 265 NSSYPAVSSIKWLKDGVRLQT----------KTGVLHLPQAAWSDAGVYTCQAENGVGSL 314 + P +S+ KW KDG L K L +P A SD G+Y+ + +N VG Sbjct: 6669 TGT-PELSA-KWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKS 6726 Query: 315 VSPPISLHIFMAEVQVSPAGPILE-----NQTVTLVCNTPNEAPSDLRYSWYKNHVL--- 366 + +S+H+ V S + + +V L C AP + + N ++ Sbjct: 6727 -NCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGP 6785 Query: 367 -LEDAHSH---TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLE 422 + + S TL L L +DTG Y C NV GS+ V + V PP +E Sbjct: 6786 KCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAV-LTVQEPPSFEQTPDSVE 6844 Query: 423 TQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLE 482 G+ + P + G L + F LE+ +++ Sbjct: 6845 VLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFV-------TELELFEVQ 6897 Query: 483 ETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDAR 542 +SG+Y C TN G+A+ T + A+ + + + TP Sbjct: 6898 PLESGDYSCLVTNDAGSASCTTHLFVKEPATFVKRLADFSVETGSPIVLEATYTGTPPIS 6957 Query: 543 FSWYLNGALLHEGPGSSLLLPAASST---------DAGSYHCRARDGHSASGPSSPAVLT 593 SW + L+ + S+ + S+ D Y C + A A+++ Sbjct: 6958 VSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIEN--EAGQDICEALVS 7015 Query: 594 VLYPPR--QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGG 651 VL PP +P L+ A G L C+VD P R+ + T L S Sbjct: 7016 VLEPPYFIEP-------LEHVEAVIGEPATLQCKVDGTPEIRISWYKEH----TKLRS-- 7062 Query: 652 GCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVL 711 +P K+ N+ + I+ + G Y C+A N++G ++SA +A L Sbjct: 7063 --------APAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKL 7114 Query: 712 AIAPSHTLQE-----GTEANLTCNVSREAAGSPANFSWFRNGVLWAQGP------LETVT 760 + L++ G C ++ P SW+++GVL + V Sbjct: 7115 PPFFARKLKDVHETLGFPVAFECRIN---GSEPLQVSWYKDGVLLKDDANLQTSFVHNVA 7171 Query: 761 LLPVARTDAA---LYACRILTEAGAQLSTPVLLSVLY--PPDRPKLSALLDMGQGHMALF 815 L + +TD + Y C G S+ L+ + PP +D+ G F Sbjct: 7172 TLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTF 7231 Query: 816 ICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYR 875 C V + ++ G ++ N+ L V ++G GD+G Y Sbjct: 7232 KCHVTGTAPIKITWAKDNR--------EIRPGGNYKMTLVENTATLTVLKVGKGDAGQYT 7283 Query: 876 CEATNVLGSSNTSLFFQVRGA---WVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYR 932 C A+N+ G + S V+ ++ PS +++ + C++ G PE WY+ Sbjct: 7284 CYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIG-GSPE-IKVLWYK 7341 Query: 933 DGQPLQESTS---------ATLRFAAITLTQAGAYHCQAQ-APGSATTSLAAPISLHVSY 982 D +QES+ A L +++ +G Y C+A A GSA++S SL V Sbjct: 7342 DETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSST----SLKVKE 7397 Query: 983 APRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLH 1042 P ++T G L C + PP + R + S + E +H Sbjct: 7398 PPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIH 7457 Query: 1043 VAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVN--VQVWPGATVREG 1100 + L + A D G Y C+A+N +G + +A V+ + G Sbjct: 7458 I--------LNVDAA---DIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTVVG 7506 Query: 1101 QLVNLTCLVWTTHPAQLTYTWYQDGQQRL------------DAHSIPLPNVTVRDATSYR 1148 + V L + P ++ W++D + + + ++ V +A Y Sbjct: 7507 KEVQLQTTIEGAEP--ISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYT 7564 Query: 1149 CGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHA 1208 C + A TL VL + ++ G + CTV P Sbjct: 7565 CQI--KNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKD 7622 Query: 1209 GRLLASSTAASVP---NTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265 G+ L S + L++ P D G YS ++P+G+ + + L++ V Sbjct: 7623 GKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPP 7682 Query: 1266 APEAAVPE-----GAPITVTCADPAAHAPTLYTWYHNGRWLQEGP---------AASLSF 1311 + + E G+ + + C + P +W+H G + G +L+ Sbjct: 7683 SFTRKLKETNGLSGSSVVMECKVYGS-PPISVSWFHEGNEISSGRKYQTTLTDNTCALTV 7741 Query: 1312 LVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDS 1371 + + +G Y+C A + G+ A L V P D + V Sbjct: 7742 NMLEESDSGDYTCIATNMAGSDECS-APLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKG 7800 Query: 1372 EPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNL 1430 PP ++ L + V + + L++ DV Y C N Sbjct: 7801 TPPFSVSWFKGSSELVPGDRCN--------VSLEDSVAELELFDVDTSQSGEYTCIVSNE 7852 Query: 1431 LGSISTIGRLQVEGARVVAEPGLD--VPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRL 1488 G S L ++ + D + +G L L G P P+ + W + Sbjct: 7853 AGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTP-PISVT-----WKKNGI 7906 Query: 1489 HAEPVPTLAFTHVARA-----------QAGMYHCLAELPTGAAASAPVMLRVLYPPKTPT 1537 + P T ++ AG Y+C E +G + + +L +L PP Sbjct: 7907 NVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQIL-ILEPPYFVK 7965 Query: 1538 MMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALR 1597 + V+ G L C++ P ++ + G + + ++ L + Sbjct: 7966 QLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFN---Q 8022 Query: 1598 VDIEALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGL 1652 VDI +D GEYIC A N +G S ST+ V+ F + L + VGL Sbjct: 8023 VDI-----NDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGL 8072 Score = 174 bits (442), Expect = 5e-43 Identities = 362/1729 (20%), Positives = 631/1729 (36%), Gaps = 258/1729 (14%) Query: 24 SSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEARF 83 S P V+ +K + + + C S EV +WY D +RQ+ S S K+ F Sbjct: 5521 SFPPIVETLKNAEVSLECELSGTPPFEV------VWYKD---KRQLRS-SKKYKIASKNF 5570 Query: 84 RGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPT 143 H ++L ++ D G Y+ + + +EV SD V + E PR + Sbjct: 5571 -----------HTSIHIL--NVDTSDIGEYHCKAQ-NEVG--SDTCVCTVKLKEPPRFVS 5614 Query: 144 IASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLH 203 + + ++ G + S + + +QW + V S+ T V ++ TL Sbjct: 5615 KLNSLTVVAGEPAELQASIEGA---QPIFVQWLKEK--EEVIRESENIRITFVENVATLQ 5669 Query: 204 MAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQ 263 A + + CQ+ ++ L V + I+ + GE TL C+ Sbjct: 5670 FAKAEPANAGKYICQIKNDGGMRENMATLMVL---EPAVIVEKAGPMTVTVGETCTLECK 5726 Query: 264 VNSSYPAVSSIKWLKDGVRLQT----------KTGVLHLPQAAWSDAGVYTCQAENGVGS 313 V + P +S ++W KDG L + K L + DAG YT Q +N VG Sbjct: 5727 VAGT-PELS-VEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGK 5784 Query: 314 LVSPPISLHIFMAEVQVSPA--------GPILENQTVTLVCNTPNEAPSDLRYSWYKNHV 365 + + +++ V P+ G +L + L C +P + +W+ Sbjct: 5785 SSCTAV---VDVSDRAVPPSFTRRLKNTGGVLGASCI-LECKVAGSSP--ISVAWFHEKT 5838 Query: 366 LLEDAHSH---------TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPV 416 + + TL+L+ +D G Y C NV GS+ V + V PP Sbjct: 5839 KIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAV-LTVQEPPSFVK 5897 Query: 417 LTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRL 476 LE G + P + G L GD + F T L Sbjct: 5898 EPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVK--GDRCNI-YFEDTVA----EL 5950 Query: 477 EIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAE--VVEGQAVTLSCRSG 534 E+ +++ + SGEY C +N+ G A+ T + ++ V G+++ L S Sbjct: 5951 ELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILE--ST 6008 Query: 535 LSPTPDARFSWYLNGALLHEGPGSSL-------LLPAASST--DAGSYHCRARDGHSASG 585 + T +W +G + ++ +L +ST DAG Y C + A Sbjct: 6009 YTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIEN--EAGR 6066 Query: 586 PSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVAT 645 A+++ L PP T +L+ A G L C+V P + D + Sbjct: 6067 DVCGALVSTLEPPYFVT-----ELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRP 6121 Query: 646 SLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFN 705 + P + N+ + + + + G Y C+A N++G AS+ F Sbjct: 6122 T--------------PEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFR 6167 Query: 706 GQATVLAIAPSHTLQE-----GTEANLTCNVSREAAGSPANFSWFRNGVLWAQGP----- 755 Q L + + L++ G LTC ++ A P W+R+GVL Sbjct: 6168 IQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSA---PIQVCWYRDGVLLRDDENLQTS 6224 Query: 756 -LETVTLLPVARTD---AALYACRILTEAGAQLSTPVLLSVLYPPDRPKLS---ALLDMG 808 ++ V L + +TD + Y+C G S+ L+ P P +D+ Sbjct: 6225 FVDNVATLKILQTDLSHSGQYSCSASNPLGTA-SSSARLTAREPKKSPFFDIKPVSIDVI 6283 Query: 809 QGHMALFICTVD-SRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELG 867 G A F C V ++P+ + + ++ G + N+ L + ++G Sbjct: 6284 AGESADFECHVTGAQPM---------RITWSKDNKEIRPGGNYTITCVGNTPHLRILKVG 6334 Query: 868 LGDSGSYRCEATNVLGSSNTSLFFQVRGA---WVQVSPSPELQEGQAVVLSCQVHTGVPE 924 GDSG Y C+ATN +G S V+ ++ S ++G+++ L C++ +G PE Sbjct: 6335 KGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKI-SGSPE 6393 Query: 925 GTSYRWYRDGQPLQESTSATLRF----AAITLTQA-----GAYHCQA-QAPGSATTSLAA 974 W+R+ L ES + F A +T+ +A G Y C+A G A+ S A Sbjct: 6394 -IKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTA- 6451 Query: 975 PISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034 L V P + + G +L C + PP ++ + + V ++ + Sbjct: 6452 ---LTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITS 6508 Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQ--ASASADFDAQAVNVQVW 1092 + LH+ L LE D G Y C+A+N +G S S F V+ Sbjct: 6509 KHFDTSLHI------LNLE-----ASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKL 6557 Query: 1093 PGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL------------DAHSIPLPNVT 1140 + G V L +V P ++ W +D + + + ++ L + Sbjct: 6558 SDTSTLIGDAVELRAIVEGFQP--ISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPE 6615 Query: 1141 VRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPP 1200 ++ Y C + S +T VL R + + G + C V P Sbjct: 6616 ASNSGKYICQIKNDAGMRECSAVLT--VLEPARIIEKPEPMTVTTGNPFALECVVTGTPE 6673 Query: 1201 AQLALSHAGRLLASST---AASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLEL- 1256 GR L++ + + L++ + D+G YS ++ +G++N ++ + Sbjct: 6674 LSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVH 6733 Query: 1257 ------------RLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEG 1304 +L+ V IL GA + + C + AP W+ +G + G Sbjct: 6734 VSDRIVPPSFIRKLKDVNAIL--------GASVVLECR-VSGSAPISVGWFQDGNEIVSG 6784 Query: 1305 PAASLSF---------LVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR 1355 P SF + + G Y+C A + G+ A L V P Sbjct: 6785 PKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGS-DECSAVLTVQEPPSFEQTPDSV 6843 Query: 1356 DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVH-SLASGTGHVQVARNALRLQVQ 1414 + + PP ++ + L + SL +++ +VQ Sbjct: 6844 EVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFVTELEL------FEVQ 6897 Query: 1415 DVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLD--VPEGAALNLSCRLLGGPG 1472 + +GD Y C N GS S L V+ + D V G+ + L G P Sbjct: 6898 PLESGD--YSCLVTNDAGSASCTTHLFVKEPATFVKRLADFSVETGSPIVLEATYTGTP- 6954 Query: 1473 PVGNSTFAWFWNDRRLHAEPVPTLAFTHVAR---------AQAGMYHCLAELPTGAAASA 1523 P+ + +W ++ + ++ T + Y CL E G Sbjct: 6955 PI---SVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDI-C 7010 Query: 1524 PVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPA 1583 ++ VL PP + VE G L C+VD P ++ + + S+ Sbjct: 7011 EALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSA------- 7063 Query: 1584 EPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRA 1632 P + N + I + SD GEY C A N +G+ ++S ++A Sbjct: 7064 -PAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKA 7111 Score = 168 bits (425), Expect = 5e-41 Identities = 315/1464 (21%), Positives = 527/1464 (35%), Gaps = 241/1464 (16%) Query: 94 EHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEG 153 E+ V + ++ + +DSG Y F+ E + D ++ P + ++ + G Sbjct: 5192 ENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLG 5251 Query: 154 TEVDFNCSTPYVCLQEQVRLQW--QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDH 211 + + C V + QW G++ + S + E + + L + +D Sbjct: 5252 SSIHMECK---VSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLEL----EDT 5304 Query: 212 GRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAV 271 +VA A S I L VK P L+ P + +P V + + P Sbjct: 5305 ANYTCKVSNVAGDDACSGI-LTVKEPP---SFLVKPGRQQAIPDSTVEFKAILKGTPP-- 5358 Query: 272 SSIKWLKDGVR----------LQTKTGVLHLPQAAWSDAGVYTCQAENGVGS-------L 314 IKW KD V L+ T L+L S G YTC N VGS L Sbjct: 5359 FKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLL 5418 Query: 315 VSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH- 373 V+ P F+ +++ S + + L C ++R W++N L + + Sbjct: 5419 VTEPPK---FVKKLEASKI--VKAGDSSRLECKIAGS--PEIRVVWFRNEHELPASDKYR 5471 Query: 374 --------TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQA 425 ++++ + D+G + CE QN GS S V+V PP+ +ET Sbjct: 5472 MTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGS-TSCSTKVIVKEPPVFSSFPPIVETLK 5530 Query: 426 GLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETD 485 L C + P +V L S S ++ S + I +++ +D Sbjct: 5531 NAEVSLECELSGTPPFEVVWYKDKRQLRS-------SKKYKIASKNFHTSIHILNVDTSD 5583 Query: 486 SGEYKCSATNSLGNATSTLDFHANAARLLISP--AAEVVEGQAVTLSCR-SGLSP----- 537 GEY C A N +G+ T +S + VV G+ L G P Sbjct: 5584 IGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQW 5643 Query: 538 ----------TPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPS 587 + + R ++ N A +L A +AG Y C+ + + Sbjct: 5644 LKEKEEVIRESENIRITFVENVA--------TLQFAKAEPANAGKYICQIK--NDGGMRE 5693 Query: 588 SPAVLTVLYPPRQPTFTTRLDLDAAG---AGAGRRGLLLCRVDSDPPARLQLLHKDRVVA 644 + A L VL P + ++ AG G L C+V P ++ +KD + Sbjct: 5694 NMATLMVLEP--------AVIVEKAGPMTVTVGETCTLECKVAGTPELSVE-WYKDGKLL 5744 Query: 645 TSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATF 704 TS S + K + + + I + ++ G Y + N +G +S +A Sbjct: 5745 TS-------------SQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVV 5791 Query: 705 NGQATVLAIAPSHTLQ---EGTEANLTCNVSREAAG-SPANFSWFRNGVLWAQGP----- 755 + + A+ PS T + G +C + + AG SP + +WF G Sbjct: 5792 D--VSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTT 5849 Query: 756 ----LETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGH 811 + T+ L + +D Y C AG+ +L+V PP K L++ G Sbjct: 5850 FSDNVCTLQLNSLDSSDMGNYTCVAANVAGSD-ECRAVLTVQEPPSFVKEPEPLEVLPGK 5908 Query: 812 MALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDS 871 F + P + F G L R E +LE+ + + S Sbjct: 5909 NVTFTSVIRGTPPFKVNWFRGARELVKG--------DRCNIYFEDTVAELELFNIDISQS 5960 Query: 872 GSYRCEATNVLG--SSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYR 929 G Y C +N G S T LF + A+++ ++ G++++L +P S Sbjct: 5961 GEYTCVVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLP--ISVT 6018 Query: 930 WYRDGQPLQES---------TSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHV 980 W +DG + S + L T AG Y C+ + A +L Sbjct: 6019 WKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLE- 6077 Query: 981 SYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPR 1040 P VT ++ G L C+V P + GD + T P Sbjct: 6078 --PPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPT-----------PE 6124 Query: 1041 LHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVRE- 1099 N L + + D G Y C+A N++G AS+ F Q + P + R+ Sbjct: 6125 YRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQL---PPSFARQL 6181 Query: 1100 -------GQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIP---LPNVT--------V 1141 G V LTC + + P Q+ WY+DG D ++ + NV + Sbjct: 6182 KDIEQTVGLPVTLTCRLNGSAPIQV--CWYRDGVLLRDDENLQTSFVDNVATLKILQTDL 6239 Query: 1142 RDATSYRCGVGPP-----------GRAPRLS-----RPITLDVLYAPRNLRLTYLLESHG 1185 + Y C P R P+ S +P+++DV+ Sbjct: 6240 SHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVI---------------A 6284 Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLL---ASSTAASVPNTLRLELRGPQPRDEGFYSCS 1242 G+ A C V P ++ S + + + T V NT L + D G Y+C Sbjct: 6285 GESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQ 6344 Query: 1243 ARSPLGQANTSLELRL-EGVRVILAPEAA--VPEGAPITVTCADPAAHAPTL-YTWYHNG 1298 A + +G+ S +L + E + + EA+ +G I + C + +P + +W+ N Sbjct: 6345 ATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLEC--KISGSPEIKVSWFRND 6402 Query: 1299 RWLQEGPAASLSFL---------VATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDA 1349 L E ++SF+ A+ +G Y C+A + G +S AL V P Sbjct: 6403 SELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGD-ASCSTALTVKAPPVFT 6461 Query: 1350 VLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNAL 1409 S + S ++QC + PP E+ D K + S + H + + L Sbjct: 6462 QKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSK---KFKITSKHFDTSLHIL 6518 Query: 1410 RLQVQDVPAGDDTYVCTAQNLLGS 1433 L+ DV Y C A N +GS Sbjct: 6519 NLEASDV----GEYHCKATNEVGS 6538 Score = 164 bits (416), Expect = 5e-40 Identities = 323/1488 (21%), Positives = 536/1488 (36%), Gaps = 223/1488 (14%) Query: 258 VTLTCQVNSSYPAVSSIKWLKDGVRL----------QTKTGVLHLPQAAWSDAGVYTCQA 307 +TL C V + P + +KWLKDG ++ + + D+G YT + Sbjct: 5158 MTLECVVAGT-PELK-VKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKV 5215 Query: 308 ENGVGSLVSPPISLHIFMAEVQVSPAGPILE-----NQTVTLVCNTPNEAPSDLRYSWYK 362 EN GS S L + + S + + ++ + C P + W+K Sbjct: 5216 ENDFGSS-SCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLP--ISAQWFK 5272 Query: 363 N---------HVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413 + + L+ S +L ++ DT Y C+V NV G + + + V PP Sbjct: 5273 DGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGI-LTVKEPPS 5331 Query: 414 TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNS 473 V QA + + + + + SG F G G S Sbjct: 5332 FLVKPG--RQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKC----FIGLEGSTS 5385 Query: 474 LRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISP--AAEVVE-GQAVTLS 530 L + ++ + +G+Y C TN +G+ + T + A+++V+ G + L Sbjct: 5386 F-LNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLE 5444 Query: 531 CRSGLSPTPDARFSWYLNGALLHEGPGSS------------LLLPAASSTDAGSYHCRAR 578 C+ ++ +P+ R W+ N HE P S + + S+ D+G + C A+ Sbjct: 5445 CK--IAGSPEIRVVWFRNE---HELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQ 5499 Query: 579 DGHSASGPSSPAVLTVLYPPRQPTFTTRLD-LDAAGAGAGRRGLLLCRVDSDPPARLQLL 637 + ++ S+ + V PP +F ++ L A L C + PP + + Sbjct: 5500 NPAGSTSCSTKVI--VKEPPVFSSFPPIVETLKNAEVS------LECELSGTPPFEV-VW 5550 Query: 638 HKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGN 697 +KD+ S S + K+ + I N + G Y C+A N +G+ Sbjct: 5551 YKDKRQLRS-------------SKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGS 5597 Query: 698 ASTSATFNGQATVLAIAP--SHTLQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGP 755 + T + ++ S T+ G A L ++ P W + + Sbjct: 5598 DTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIE---GAQPIFVQWLKEKEEVIRES 5654 Query: 756 -------LETVTLLPVARTD---AALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALL 805 +E V L A+ + A Y C+I + G + + L+ VL P + + + Sbjct: 5655 ENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLM-VLEPAVIVEKAGPM 5713 Query: 806 DMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRE 865 + G C V P + + LL +S + + + + L + Sbjct: 5714 TVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISS--------LRILS 5765 Query: 866 LGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE-----GQAVVLSCQVHT 920 + D+G+Y + N +G S+ + V V S + L+ G + +L C+V Sbjct: 5766 VERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAG 5825 Query: 921 GVPEGTSYRWYRD------GQPLQESTS---ATLRFAAITLTQAGAYHCQAQAPGSATTS 971 P S W+ + G Q + S TL+ ++ + G Y C A + Sbjct: 5826 SSP--ISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDEC 5883 Query: 972 LAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGV 1031 A L V P V ++ PG+ + PP ++ G R + Sbjct: 5884 RAV---LTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVK----- 5935 Query: 1032 GGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQ--AVNV 1089 R ++ LE+ + G Y C SN GQAS + + A + Sbjct: 5936 ------GDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFL 5989 Query: 1090 QVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS-----------IPLPN 1138 + +V G+ + L T P ++ TW +DG + + + N Sbjct: 5990 KRLSDHSVEPGKSIILESTYTGTLP--ISVTWKKDGFNITTSEKCNIVTTEKTCILEILN 6047 Query: 1139 VTVRDATSYRCGV-GPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDS 1197 T RDA Y C + GR + TL+ Y L LE+ G + C V Sbjct: 6048 STKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEP---LEAAVGDSVSLQCQVAG 6104 Query: 1198 RPPAQLALSHAGRLLASSTAASV---PNTLRLELRGPQPRDEGFYSCSARSPLGQANTSL 1254 P ++ L + N L D G Y+C A + +G A++ Sbjct: 6105 TPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKT 6164 Query: 1255 ELRLEG-------VRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGP-- 1305 R++ R + E V G P+T+TC + AP WY +G L++ Sbjct: 6165 VFRIQERQLPPSFARQLKDIEQTV--GLPVTLTCRLNGS-APIQVCWYRDGVLLRDDENL 6221 Query: 1306 -------AASLSFLVATRAHAGAYSCQAQDAQGTRSS--RPAALQVLYAPQDAVLSSFRD 1356 A+L L +H+G YSC A + GT SS R A + +P + D Sbjct: 6222 QTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSID 6281 Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416 A A +C V P + S D K + G + N L++ V Sbjct: 6282 VIAGESADFECHVTGAQPMRITWSKDNKEIRPG--------GNYTITCVGNTPHLRILKV 6333 Query: 1417 PAGDD-TYVCTAQNLLGSISTIGRLQV-EGARVVA--EPGLDVPEGAALNLSCRLLGGPG 1472 GD Y C A N +G +L V E + V E +G ++ L C++ G P Sbjct: 6334 GKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSP- 6392 Query: 1473 PVGNSTFAWFWNDRRLHAE---------PVPTLAFTHVARAQAGMYHCLAELPTGAAASA 1523 +WF ND LH V L + +G Y C A G A S Sbjct: 6393 ---EIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDA-SC 6448 Query: 1524 PVMLRVLYPPKTPTMMVFVE---PEGGLRG---ILDCRVDSEPLASLTLHLGSRLVASSQ 1577 L V PP VF + P G L+G IL C + P + + V +S+ Sbjct: 6449 STALTVKAPP------VFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSK 6502 Query: 1578 PQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTS 1625 ++ H S + L L SD GEY C A+N +GS + S Sbjct: 6503 KFKITSK---HFDTSLHILN-----LEASDVGEYHCKATNEVGSDTCS 6542 Score = 161 bits (407), Expect = 6e-39 Identities = 347/1631 (21%), Positives = 583/1631 (35%), Gaps = 258/1631 (15%) Query: 135 VTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPT 194 V E P PVE+++ ++V+ C V + W + R + +S+K+ T Sbjct: 4951 VKEPPTFIRELKPVEVVKYSDVELECE---VTGTPPFEVTWLKNN--REIR-SSKKYTLT 5004 Query: 195 GVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILP 254 + LH+ +C +S + +K P +K + + + +L Sbjct: 5005 DRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTT--TVLK 5062 Query: 255 GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYT 304 T V S P SI WLKD L V L + +G YT Sbjct: 5063 SS-ATFQSTVAGSPPI--SITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYT 5119 Query: 305 CQAENGVGS-------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVC---NTPNEAPS 354 CQA+N G LV P + V+ + + + E +TL C TP Sbjct: 5120 CQAKNESGVERCYAFLLVQEPAQI------VEKAKSVDVTEKDPMTLECVVAGTP----- 5168 Query: 355 DLRYSWYKNHVLLEDAHSHTL---------RLHLATRADTGFYFCEVQNVHGSERSGPVS 405 +L+ W K+ + + ++ R+ + D+G Y +V+N GS Sbjct: 5169 ELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYL 5228 Query: 406 VVVNH---PPLTPVLTAFLETQAGLVGILHCSVV-SEPLATLVLSHGGHILASTSGDSDH 461 V++ P T LT ++ G + C V S P++ G I S Sbjct: 5229 RVLDQNIPPSFTKKLTK-MDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSA------ 5281 Query: 462 SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGN-ATSTLDFHANAARLLISPAAE 520 ++ S+ LE+ +LE D+ Y C +N G+ A S + L+ P + Sbjct: 5282 --KYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQ 5339 Query: 521 VVEGQAV---TLSCRSGLSPTPDARFSWYLNGALLHEGPG---------SSLLLPAASST 568 QA+ T+ ++ L TP + W+ + L GP S L L + ++ Sbjct: 5340 ----QAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDAS 5395 Query: 569 DAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDS 628 G Y C H + S + T+L P F +L+ AG L C++ Sbjct: 5396 KTGQYTC-----HVTNDVGSDSCTTMLLVTEPPKFVKKLEASKI-VKAGDSSRLECKIAG 5449 Query: 629 DPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYL 688 P R+ + LP+ S + ++T ++ ++++N E+ G ++ Sbjct: 5450 SPEIRVVWFRNEH----ELPA----------SDKYRMTFIDSVAVIQMNNLSTEDSGDFI 5495 Query: 689 CEASNALGNAS--TSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFR 746 CEA N G+ S T + P + E +L C +S P W++ Sbjct: 5496 CEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELS---GTPPFEVVWYK 5552 Query: 747 NG---------VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPD 797 + + ++ ++ +L V +D Y C+ E G+ T V L P Sbjct: 5553 DKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSD--TCVCTVKLKEPP 5610 Query: 798 R--PKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAE 855 R KL++L + L ++P+ + L E ++ S ++ Sbjct: 5611 RFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITF--------V 5662 Query: 856 ANSLKLEVRELGLGDSGSYRCEATNVLGS-SNTSLFFQVRGAWVQVSPSP-ELQEGQAVV 913 N L+ + ++G Y C+ N G N + + A + P + G+ Sbjct: 5663 ENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCT 5722 Query: 914 LSCQVHTGVPEGTSYRWYRDGQPLQESTS---------ATLRFAAITLTQAGAYHCQAQA 964 L C+V G PE S WY+DG+ L S ++LR ++ AG Y Q Q Sbjct: 5723 LECKV-AGTPE-LSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQN 5780 Query: 965 PGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLG---LLLCRVDSDPPAQLRLLHGD 1021 +S A + + P T L +TG G LG +L C+V P + H Sbjct: 5781 -NVGKSSCTAVVDVSDRAVPPSFT-RRLKNTG-GVLGASCILECKVAGSSPISVAWFHEK 5837 Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081 + S + + N L+++ D G Y C A+N G A Sbjct: 5838 TKIVS-----------GAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAV 5886 Query: 1082 FDAQAVNVQVWPGATVRE--------GQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH- 1132 Q P + V+E G+ V T ++ T P ++ W++ ++ + Sbjct: 5887 LTVQE------PPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVN--WFRGARELVKGDR 5938 Query: 1133 ----------SIPLPNVTVRDATSYRCGVGP-PGRAPRLSRPITLDVLYAPRNLRLTYLL 1181 + L N+ + + Y C V G+A +R L+ L Sbjct: 5939 CNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTR------LFVKEPAAFLKRL 5992 Query: 1182 ESHG---GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLR---LELRGPQPRD 1235 H G+ ++ T P + G + +S ++ T + LE+ RD Sbjct: 5993 SDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRD 6052 Query: 1236 EGFYSCSARSPLGQ-ANTSLELRLEGVRVI--LAP-EAAVPEGAPITVTCADPAAHAPTL 1291 G YSC + G+ +L LE + L P EAAV G +++ C T+ Sbjct: 6053 AGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAV--GDSVSLQCQVAGTPEITV 6110 Query: 1292 YTWYHNGRWLQEGP---------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPA-ALQ 1341 +WY L+ P A+L F +G Y+C+A+++ GT SS+ +Q Sbjct: 6111 -SWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQ 6169 Query: 1342 VLYAPQDAVLSSFRDSRARSMAV-IQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTG 1400 P + + V + C ++ P ++ DG +L + T Sbjct: 6170 ERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQ-----TS 6224 Query: 1401 HVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARV-----VAEPGLDV 1455 V LQ +G Y C+A N LG+ S+ RL + + +DV Sbjct: 6225 FVDNVATLKILQTDLSHSGQ--YSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDV 6282 Query: 1456 PEGAALNLSCRLLGGPG-------------PVGNSTFAWFWNDRRLHAEPVPTLAFTHVA 1502 G + + C + G P GN T N P L V Sbjct: 6283 IAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGN--------TPHLRILKVG 6334 Query: 1503 RAQAGMYHCLAELPTGAAASAPVMLRVLYPPK-TPTMMVFVEPEGGLRGILDCRVDSEPL 1561 + +G Y C A G + L V PPK + + G L+C++ P Sbjct: 6335 KGDSGQYTCQATNDVGKDMCS-AQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPE 6393 Query: 1562 ASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621 ++ + S + +L I D G+YIC A N +G Sbjct: 6394 IKVSWFRNDSELHESWKYNMSFINSVALLT--------INEASAEDSGDYICEAHNGVGD 6445 Query: 1622 ASTSTYFGVRA 1632 AS ST V+A Sbjct: 6446 ASCSTALTVKA 6456 Score = 158 bits (400), Expect = 4e-38 Identities = 348/1716 (20%), Positives = 599/1716 (34%), Gaps = 260/1716 (15%) Query: 53 DGITAIWYYDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGS 112 D + A WY D +E F+ + E R+ + + + + D+G Sbjct: 3173 DDVDAHWYKDG---------------IEINFQVQERHKYVVERRIHRMFISETRQSDAGE 3217 Query: 113 YNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVR 172 Y F ++ NR S V E P+V PV + G F C+ + + Q + Sbjct: 3218 YTF---VAGRNRSSVT--LYVNAPEPPQVLQELQPVTVQSGKPARF-CAV--ISGRPQPK 3269 Query: 173 LQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQ----LSVANHRAQS 228 + W ++ S F + G TL + ++ + + C+ VA A Sbjct: 3270 ISWYKEEQLLSTGFKCKFLHD---GQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASL 3326 Query: 229 EIHLQVKYAPKGVKILLSPSGRNIL------PGELVTLTCQVNSSYPAVSSIKWLKDGVR 282 + + +P + P+ L G+ C+V+ + VS W + Sbjct: 3327 SVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVS---WYSKDKK 3383 Query: 283 LQTK----------TGVLHLPQAAWSDAGVYTCQAENGVG--------SLVSPPISLH-I 323 ++ T L + +A D G YT A N VG SL +P LH Sbjct: 3384 IKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHER 3443 Query: 324 FMAEVQVS-PAGPILENQTVTL----------VCNTPNEAPSDLRYSWYKNHVLLEDAHS 372 E+++ A P+++ + L C ++ ++R+ W+K + ++ Sbjct: 3444 IEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEI--QSAPNVRFQWFKAGREIYESDK 3501 Query: 373 HTLRLH--------LATR-ADTGFYFCEVQNVHGS-ERSGPVSVVVNHPPLTPVLTAFLE 422 ++R L T+ D G Y C+ N +GS + ++V +PP L Sbjct: 3502 CSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLT 3561 Query: 423 TQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLE 482 T G C+V P+ + G L+ SP + + N LE+ +L Sbjct: 3562 TFVGKAAKFICTVTGTPVIETIWQKDGAALSP-------SPNWRISDAENKHILELSNLT 3614 Query: 483 ETDSGEYKCSATNSLG--------------NATSTLDFHANAARLLISPAAEVVEGQAVT 528 D G Y C A+N G + L+ +A + +V E + VT Sbjct: 3615 IQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINKKVHLECQVDEDRKVT 3674 Query: 529 LSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSS 588 ++ P + + + E ++L +P A D+G+Y C A + A S Sbjct: 3675 VTWSKDGQKLPPGK-----DYKICFEDKIATLEIPLAKLKDSGTYVCTA--SNEAGSSSC 3727 Query: 589 PAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLP 648 A +TV P P+F ++D G L C++ P ++ ++ ++ S Sbjct: 3728 SATVTVREP---PSFVKKVDPSYLML-PGESARLHCKLKGSPVIQVTWFKNNKELSES-- 3781 Query: 649 SGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG--NASTSATFNG 706 + RM + +L +I + +E+ G Y CEA N +G + ST Sbjct: 3782 ----------NTVRMYFVNSEAIL--DITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKE 3829 Query: 707 QATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLE 757 + + + GT A L C VS P SWF++ L++Q L Sbjct: 3830 PPSFIKTLEPADIVRGTNALLQCEVS---GTGPFEISWFKDKKQIRSSKKYRLFSQKSLV 3886 Query: 758 TVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFIC 817 + + D Y C + E G L P K+ L+ +G + L Sbjct: 3887 CLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAA 3946 Query: 818 TVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCE 877 S P++ + G+ + + G+ + L + ++ + G Y C Sbjct: 3947 VRGSEPIS-VTWMKGQEV--------IREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCL 3997 Query: 878 ATNVLGSSNT--SLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQ 935 A N GS + L + ++ + ++ G L V G PE +WY+DG+ Sbjct: 3998 AENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTV-AGTPE-LKPKWYKDGR 4055 Query: 936 PLQESTS---------ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRH 986 PL S A L+F + L +G Y + +++ L AP Sbjct: 4056 PLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFF 4115 Query: 987 VTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVA 1046 +D+ L C++ P ++ + +A +S R +A Sbjct: 4116 TKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIA-----------ASDRYRIAFV 4164 Query: 1047 PNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNL- 1105 T LEI + D G + C A+N++G +S A+ VQ P + G L Sbjct: 4165 EGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSG-----ALIVQEPPSFVTKPGSKDVLP 4219 Query: 1106 ---TCLVWTTH-PAQLTYTWYQDGQQRLDA-----------HSIPLPNVTVRDATSYRCG 1150 CL T LT W++ ++ + S+ L V D+ +Y C Sbjct: 4220 GSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCK 4279 Query: 1151 VGPPGRAPRLSRPITL-DVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAG 1209 V S + + + L + LL+ G + C V PP ++ Sbjct: 4280 VSNVAGGVECSANLFVKEPATFVEKLEPSQLLKK--GDATQLACKVTGTPPIKITWFAND 4337 Query: 1210 RLLASST---AASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILA 1266 R + S+ + V +T L L D G Y C A++ G + S + ++ Sbjct: 4338 REIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCS------SIVIVKE 4391 Query: 1267 PEAAVPEGAPITV-------TCADPAAHAPTLYTWYHNGRWLQEG---------PAASLS 1310 E PI V A+ A P TW+ + L+ G SL Sbjct: 4392 SPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQ 4451 Query: 1311 FLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR-SMAVIQCTV 1369 L A AG Y C+ + G SS +A L P + S R A Q T+ Sbjct: 4452 ILKFVAADAGEYQCRVTNEVG--SSICSARVTLREPPSFIKKIESTSSLRGGTAAFQATL 4509 Query: 1370 DSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPA-GDDTYVCTAQ 1428 P + D + + + N L + + D YVC A+ Sbjct: 4510 KGSLPITVTWLKDSDEITEDDNI--------RMTFENNVASLYLSGIEVKHDGKYVCQAK 4561 Query: 1429 NLLGSISTIGRLQVEGARVVAEP--GLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDR 1486 N G L V+ + E +DV +G L + G T WF + + Sbjct: 4562 NDAGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSG----TKEITAKWFKDGQ 4617 Query: 1487 RLH---------AEPVPTLAFTHVARAQAGMYHCLAELPTG-AAASAPV-MLRVLYPPKT 1535 L + V L + +G Y + G ++ A + +L ++ PP Sbjct: 4618 ELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSF 4677 Query: 1536 PTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNA 1595 + ++ G L+C V S+ + +++S+ N Sbjct: 4678 TKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASE--------KYKFSFHDNT 4729 Query: 1596 LRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631 ++I L +D G Y CSA+N G S + V+ Sbjct: 4730 AFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVK 4765 Score = 157 bits (396), Expect = 1e-37 Identities = 328/1640 (20%), Positives = 590/1640 (35%), Gaps = 234/1640 (14%) Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159 L L D+ EDSG Y ++ SD ++V V E P P+E+L+ +V Sbjct: 4357 LRLTDVGIEDSGEYMCE---AQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLL 4413 Query: 160 CSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQL 219 V + W + ++ + +K++ HL +L + +C++ Sbjct: 4414 AE---VAGTPPFEITWFKDN---TILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRV 4467 Query: 220 SVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKD 279 + + + ++ P +K + S S L G + S P ++ WLKD Sbjct: 4468 TNEVGSSICSARVTLREPPSFIKKIESTSS---LRGGTAAFQATLKGSLPI--TVTWLKD 4522 Query: 280 G--------VRLQTKTGV--LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQ 329 +R+ + V L+L G Y CQA+N G + A + Sbjct: 4523 SDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAG--------IQRCSALLS 4574 Query: 330 VSPAGPILENQTVTLVCNTPNEAPSDLRYS--------WYKN----------HVLLEDAH 371 V I E + V++ + A +++S W+K+ + + D Sbjct: 4575 VKEPATITE-EAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTDTV 4633 Query: 372 SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGI- 430 S L++ + D+G Y EVQN G S + V + P T L+ + G Sbjct: 4634 S-ILKIISTEKKDSGEYTFEVQNDVGRS-SCKARINVLDLIIPPSFTKKLKKMDSIKGSF 4691 Query: 431 --LHCSVV-SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487 L C V S P++ I AS ++ + N+ LEI LE TDSG Sbjct: 4692 IDLECIVAGSHPISIQWFKDDQEISASE--------KYKFSFHDNTAFLEISQLEGTDSG 4743 Query: 488 EYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYL 547 Y CSATN G+ + + + ++ + T W+ Sbjct: 4744 TYTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFK 4803 Query: 548 NGALLHEG---------PGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598 + LH G +SL L AA +TD+G+Y C+ + +S A L V PP Sbjct: 4804 DNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQL--SNDVGTATSKATLFVKEPP 4861 Query: 599 R-----QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGC 653 + P R G+ C++ P R+ + D T++ G Sbjct: 4862 QFIKKPSPVLVLR---------NGQSTTFECQITGTPKIRVS-WYLDGNEITAIQKHG-- 4909 Query: 654 STCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAI 713 ++ L +I +E G Y+CEA N G AS S + I Sbjct: 4910 -----------ISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFI 4958 Query: 714 APSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVT---------LL 762 ++ + ++ L C V+ P +W +N T+T + Sbjct: 4959 RELKPVEVVKYSDVELECEVT---GTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHIT 5015 Query: 763 PVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSR 822 +D Y C I++ G S +++ PP K A F TV Sbjct: 5016 KCDPSDTGEYQC-IVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGS 5074 Query: 823 PLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVL 882 P + + +L + L++R + G SG Y C+A N Sbjct: 5075 PPISITWLKDDQIL--------DEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNES 5126 Query: 883 GSSNTSLFFQVR--GAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQ-- 938 G F V+ V+ + S ++ E + L C V G PE +W +DG+ + Sbjct: 5127 GVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVV-AGTPE-LKVKWLKDGKQIVPS 5184 Query: 939 -------ESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTT 991 E+ A+ R ++ +G Y + + +++ A L + P T Sbjct: 5185 RYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLT 5244 Query: 992 LMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLR 1051 MD G + C+V P + + ++ +S + + ++ Sbjct: 5245 KMDKVLGSSIHMECKVSGSLPISAQWFKDGKEIS-----------TSAKYRLVCHERSVS 5293 Query: 1052 LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQ-------LVN 1104 LE++ LED Y C+ SN G + S + V+ P V+ G+ V Sbjct: 5294 LEVNNLELEDTANYTCKVSNVAGDDACSG-----ILTVKEPPSFLVKPGRQQAIPDSTVE 5348 Query: 1105 LTCLVWTTHPAQLTYTWYQDGQQRLDAHS-----------IPLPNVTVRDATSYRCGV-G 1152 ++ T P ++ W++D + + + L +V Y C V Sbjct: 5349 FKAILKGTPPFKI--KWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTN 5406 Query: 1153 PPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLL 1212 G + + + + L + ++++ G + + C + P ++ L Sbjct: 5407 DVGSDSCTTMLLVTEPPKFVKKLEASKIVKA--GDSSRLECKIAGSPEIRVVWFRNEHEL 5464 Query: 1213 ASS---TAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVI--LAP 1267 +S + + +++ D G + C A++P G + S ++ ++ V P Sbjct: 5465 PASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPP 5524 Query: 1268 EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPA---------ASLSFLVATRAH 1318 + A +++ C + + P WY + R L+ S+ L + Sbjct: 5525 IVETLKNAEVSLEC-ELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSD 5583 Query: 1319 AGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELA 1378 G Y C+AQ+ G+ + +++ P+ + A A +Q +++ P + Sbjct: 5584 IGEYHCKAQNEVGS-DTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQ 5642 Query: 1379 -LSHDGKVLATSSGVHSLASGTGHVQVARNALRLQ-VQDVPAGDDTYVCTAQNLLGSIST 1436 L +V+ S + + N LQ + PA Y+C +N G Sbjct: 5643 WLKEKEEVIRESENI--------RITFVENVATLQFAKAEPANAGKYICQIKNDGGMREN 5694 Query: 1437 IGRLQV-EGARVVAEPG-LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA---- 1490 + L V E A +V + G + V G L C++ G P + W+ + + L + Sbjct: 5695 MATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTP----ELSVEWYKDGKLLTSSQKH 5750 Query: 1491 -----EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPE 1545 + +L V R AG Y + G +S ++ V P+ ++ Sbjct: 5751 KFSFYNKISSLRILSVERQDAGTYTFQVQNNVG-KSSCTAVVDVSDRAVPPSFTRRLKNT 5809 Query: 1546 GGLRG---ILDCRV-DSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIE 1601 GG+ G IL+C+V S P++ H +++V+ ++ Q S N + + Sbjct: 5810 GGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQ---------TTFSDNVCTLQLN 5860 Query: 1602 ALRPSDQGEYICSASNVLGS 1621 +L SD G Y C A+NV GS Sbjct: 5861 SLDSSDMGNYTCVAANVAGS 5880 Score = 150 bits (380), Expect = 8e-36 Identities = 314/1497 (20%), Positives = 525/1497 (35%), Gaps = 247/1497 (16%) Query: 253 LPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTK----------TGVLHLPQAAWSDAGV 302 + G + L C V S+P SI+W KD + T L + Q +D+G Sbjct: 4687 IKGSFIDLECIVAGSHPI--SIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGT 4744 Query: 303 YTCQAENGVG--------SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPS 354 YTC A N G ++ PP F+ + Q P Q LV T AP Sbjct: 4745 YTCSATNKAGHNQCSGHLTVKEPPY----FVEKPQSQDVNPNTRVQLKALVGGT---APM 4797 Query: 355 DLRYSWYKNHVLL---------EDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVS 405 ++ W+K++ L +D S +L L A D+G Y C++ N G+ S Sbjct: 4798 TIK--WFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATL 4855 Query: 406 VVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRF 465 V P + L + G C + P + G+ + + Sbjct: 4856 FVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKH------- 4908 Query: 466 SGTSGPNSLR-LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA--AEVV 522 G S + L +I +SG Y C A N G A+ +++ I EVV Sbjct: 4909 -GISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRELKPVEVV 4967 Query: 523 EGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLL---------LPAASSTDAGSY 573 + V L C ++ TP +W N + +L + +D G Y Sbjct: 4968 KYSDVELECE--VTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEY 5025 Query: 574 HCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPAR 633 C + G S + L P P+F +++ + V PP Sbjct: 5026 QCIVSN---EGGSCSCSTRVALKEP--PSFIKKIENTTTVLKSS--ATFQSTVAGSPPIS 5078 Query: 634 LQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASN 693 + L D+++ + ++ ++ ++I + G Y C+A N Sbjct: 5079 ITWLKDDQILDED--------------DNVYISFVDSVATLQIRSVDNGHSGRYTCQAKN 5124 Query: 694 ALGNASTSATFNGQ--ATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNGV- 749 G A Q A ++ A S + E L C V AG+P W ++G Sbjct: 5125 ESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVV----AGTPELKVKWLKDGKQ 5180 Query: 750 --------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVL---YPPDR 798 + + + + + V + D+ Y ++ + G+ S L VL PP Sbjct: 5181 IVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSS-SCDAYLRVLDQNIPPSF 5239 Query: 799 PKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANS 858 K +D G C V S L + A + + G ++ + +++ S Sbjct: 5240 TKKLTKMDKVLGSSIHMECKV-SGSLPISAQWFKD-------GKEISTSAKYRLVCHERS 5291 Query: 859 LKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEG--QAVVLSC 916 + LEV L L D+ +Y C+ +NV G S V+ PS ++ G QA+ S Sbjct: 5292 VSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVK-----EPPSFLVKPGRQQAIPDST 5346 Query: 917 QVHTGVPEGT---SYRWYRDGQPL---------QESTSATLRFAAITLTQAGAYHCQAQ- 963 + +GT +W++D L E +++ L ++ ++ G Y C Sbjct: 5347 VEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTN 5406 Query: 964 --APGSATTSLAAPISLHVSYAPRHV-TLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020 S TT L V+ P+ V L G L C++ P ++ Sbjct: 5407 DVGSDSCTTMLL------VTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRN 5460 Query: 1021 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080 + + +S + + + ++++ ED G +ICEA N G S S Sbjct: 5461 EHELP-----------ASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCST 5509 Query: 1081 DFDAQAVNV--QVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH------ 1132 + V P + V+L C + T P ++ WY+D +Q + Sbjct: 5510 KVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEV--VWYKDKRQLRSSKKYKIAS 5567 Query: 1133 -----SIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQ 1187 SI + NV D Y C + T+ + PR + L G+ Sbjct: 5568 KNFHTSIHILNVDTSDIGEYHCKA--QNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGE 5625 Query: 1188 LALVLCTVDSRPPAQLA-LSHAGRLLASS---TAASVPNTLRLELRGPQPRDEGFYSCSA 1243 A + +++ P + L ++ S V N L+ +P + G Y C Sbjct: 5626 PAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQI 5685 Query: 1244 RSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCAD------PAAHAPTL-YTWYH 1296 ++ G L ++L P V + P+TVT + A P L WY Sbjct: 5686 KNDGGMRENMATL------MVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYK 5739 Query: 1297 NGRWLQE---------GPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQ 1347 +G+ L +SL L R AG Y+ Q Q+ G +SS A + V Sbjct: 5740 DGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVG-KSSCTAVVDV---SD 5795 Query: 1348 DAVLSSFRDSRAR------SMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGH 1401 AV SF + +++C V P +A H+ + + + + S Sbjct: 5796 RAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSD--- 5852 Query: 1402 VQVARNALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQV-EGARVVAEP-GLDVPEG 1458 N LQ+ + + D Y C A N+ GS L V E V EP L+V G Sbjct: 5853 -----NVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPG 5907 Query: 1459 AALNLSCRLLGGPGPVGNSTFAWFWNDRRL---------HAEPVPTLAFTHVARAQAGMY 1509 + + + G P N WF R L + V L ++ +Q+G Y Sbjct: 5908 KNVTFTSVIRGTPPFKVN----WFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEY 5963 Query: 1510 HCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTL--- 1566 C+ G A+ T + EP L+ + D V EP S+ L Sbjct: 5964 TCVVSNNAGQASCT-------------TRLFVKEPAAFLKRLSDHSV--EPGKSIILEST 6008 Query: 1567 HLGSRLVASSQPQ---GAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620 + G+ ++ + + +++ + ++I D G+Y C N G Sbjct: 6009 YTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAG 6065 Score = 140 bits (353), Expect = 1e-32 Identities = 293/1321 (22%), Positives = 474/1321 (35%), Gaps = 211/1321 (15%) Query: 135 VTEEPRVPTIASPVELLEGTEVDFNCSTPYVCL---QEQVRLQWQGQDPARSVTFNSQKF 191 V E PR P +++ E T Y C ++++ W + S KF Sbjct: 7301 VQEPPRFIKKLEPSRIVKQDEF-----TRYECKIGGSPEIKVLWYKDETEIQ---ESSKF 7352 Query: 192 EPTGVGHLETLHMA-MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGR 250 + V + L M +S +D G C+ A A S L+VK P K P Sbjct: 7353 RMSFVDSVAVLEMHNLSVEDSGDYT-CEAHNAAGSASSSTSLKVKEPPIFRK---KPHPI 7408 Query: 251 NILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDA 300 L G V L C++ + P + W KD L++ +H+ +D Sbjct: 7409 ETLKGADVHLECELQGTPPF--HVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADI 7466 Query: 301 GVYTCQAENGVGS--------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEA 352 G Y C+A N VGS L +PP + ++S ++ + + T E Sbjct: 7467 GEYQCKATNDVGSDTCVGSIALKAPPRFVK------KLSDISTVVGKE---VQLQTTIEG 7517 Query: 353 PSDLRYSWYK----------NHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSG 402 + W+K N + + TL+ A+ G Y C+++N G + Sbjct: 7518 AEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECF 7577 Query: 403 PVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEP-LATLVLSHGGHILASTSGDSDH 461 ++ V P ++ G L C+V P L+T G + TS + Sbjct: 7578 -ATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKEL---TSDNKYK 7633 Query: 462 SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEV 521 F+ SG L+I ++ +DSG Y N +G + T + + S ++ Sbjct: 7634 ISFFNKVSG-----LKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKL 7688 Query: 522 VE-----GQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPG---------SSLLLPAASS 567 E G +V + C+ + +P SW+ G + G +L + Sbjct: 7689 KETNGLSGSSVVMECK--VYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEE 7746 Query: 568 TDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLD-LDAAGAGAGRRGLLLCRV 626 +D+G Y C A + + S+P LTV PP +F + D +D G V Sbjct: 7747 SDSGDYTCIATNMAGSDECSAP--LTVREPP---SFVQKPDPMDVL---TGTNVTFTSIV 7798 Query: 627 DSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGL 686 PP + ++ L G C+ V+ ++ +E+ + + G Sbjct: 7799 KGTPPFSVSWFKG----SSELVPGDRCN----------VSLEDSVAELELFDVDTSQSGE 7844 Query: 687 YLCEASNALGNAS--TSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSW 744 Y C SN G AS T A + +++++G L + P + +W Sbjct: 7845 YTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFT---GTPPISVTW 7901 Query: 745 FRNGVLWAQGPLETVT------LLPVART---DAALYACRILTEAGAQLSTPVLLSVLYP 795 +NG+ +T +L + + DA Y C I +G + +L +L P Sbjct: 7902 KKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQIL-ILEP 7960 Query: 796 PDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAE 855 P K + + G A C + P ++ + G+ T L P F+ Sbjct: 7961 PYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGD----TKLRPTTTYKMHFRN--- 8013 Query: 856 ANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE-----GQ 910 N L ++ + DSG Y C+A N +G + S F V+ + S S +L++ G Sbjct: 8014 -NVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGL 8072 Query: 911 AVVLSCQVHTGVPEGTSYRWYRDGQPLQES---------TSATLRFAAITLTQAGAYHCQ 961 VV C + P S WY+DG+PL++S +ATL + AG Y C Sbjct: 8073 PVVFDCAISGSEPISVS--WYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCT 8130 Query: 962 AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGD 1021 A P + +S A I P +D G C V P ++ Sbjct: 8131 ATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDS 8190 Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081 R + S GG + ++ N+ L + D G Y C A N +G+ S +A Sbjct: 8191 REIRS-----GG------KYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQ 8239 Query: 1082 FDAQAVNVQVWPGATVR--------EGQLVNLTCLVWTTHPAQLTYTWYQDGQ--QRLDA 1131 + + + P T R EG L V + P +T WY++ Q Sbjct: 8240 LNIKERLIP--PSFTKRLSETVEETEGNSFKLEGRVAGSQP--ITVAWYKNNIEIQPTSN 8295 Query: 1132 HSIPLPNVTV---------RDATSYRCGVGPPGRAPRLSRPITLDVLYAPR--NLRLTYL 1180 I N T+ DA Y C V + + I + P + LT + Sbjct: 8296 CEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPV 8355 Query: 1181 LESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAAS---VPNTLRLELRGPQPRDEG 1237 S G + L C V P ++ AGR + S S T LELR D G Sbjct: 8356 TVSEGEYVQLS-CHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSG 8414 Query: 1238 FYSCSARSPLGQANTSLELRLEGVRVILAP---EAAV---------PEGAPI----TVTC 1281 Y C A + G T ++ ++ + +AP +AAV P+ + T T Sbjct: 8415 DYVCKASNVAGSDTTKSKVTIKD-KPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATF 8473 Query: 1282 ADPAAHAPTLYTWYHNGRWL-----------QEGPAASLSFLVATRAHAGAYSCQAQDAQ 1330 P + G+W Q+G A L T+ +G Y C A + Sbjct: 8474 IAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEH 8533 Query: 1331 G 1331 G Sbjct: 8534 G 8534 Score = 119 bits (297), Expect = 3e-26 Identities = 188/853 (22%), Positives = 310/853 (36%), Gaps = 121/853 (14%) Query: 95 HRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTV-TEEPRVPTIASPVELLEG 153 ++V L + ++ P DSG Y+F + + V + S V+ T P L G Sbjct: 7638 NKVSGLKIINVAPSDSGVYSFEVQ-NPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSG 7696 Query: 154 TEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGR 213 + V C V + + W + S + +K++ T + L + M + Sbjct: 7697 SSVVMECK---VYGSPPISVSWFHEGNEIS---SGRKYQTTLTDNTCALTVNMLEESDSG 7750 Query: 214 ILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSS 273 C + + L V+ P V+ P ++L G VT T V + P S Sbjct: 7751 DYTCIATNMAGSDECSAPLTVREPPSFVQ---KPDPMDVLTGTNVTFTSIVKGTPPF--S 7805 Query: 274 IKWLKDG----------VRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSL-------VS 316 + W K V L+ L L S +G YTC N G + Sbjct: 7806 VSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIK 7865 Query: 317 PPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH----- 371 P + + + P++ T T TP + +W KN + + + Sbjct: 7866 APAKFVKRLNDYSIEKGKPLILEGTFT---GTP-----PISVTWKKNGINVTPSQRCNIT 7917 Query: 372 ----SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGL 427 S L + +T D G Y C ++N G + S +++ PP ++ G Sbjct: 7918 TTEKSAILEIPSSTVEDAGQYNCYIENASGKD-SCSAQILILEPPYFVKQLEPVKVSVGD 7976 Query: 428 VGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487 L C + P + G L T+ H N L ++ DSG Sbjct: 7977 SASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRN-------NVATLVFNQVDINDSG 8029 Query: 488 EYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE-----GQAVTLSCRSGLSPTPDAR 542 EY C A NS+G +++ +L S + ++ + G V C +S + Sbjct: 8030 EYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDC--AISGSEPIS 8087 Query: 543 FSWYLNGALLHEGPG--SSLLLPAAS----STD---AGSYHCRARDGHSASGPSSPAVLT 593 SWY +G L + P +S L A+ TD AG Y C A + ++ S+ +LT Sbjct: 8088 VSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILT 8147 Query: 594 VLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGC 653 P P F RL A G C V P ++ R + SGG Sbjct: 8148 EGKNP--PFFDIRLA--PVDAVVGESADFECHVTGTQPIKVSWAKDSREIR----SGG-- 8197 Query: 654 STCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAI 713 + +++ N + + + G Y C A N +G S +A N + + I Sbjct: 8198 --------KYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERL--I 8247 Query: 714 APSHTLQ-----EGTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLETV 759 PS T + E TE N R A P +W++N + + + + Sbjct: 8248 PPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVL 8307 Query: 760 TLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLS----ALLDMGQGHMALF 815 + DA LY C++ +AG+ L T + V+ P +P + + + +G Sbjct: 8308 QVRKAGMNDAGLYTCKVSNDAGSALCTSSI--VIKEPKKPPVFDQHLTPVTVSEGEYVQL 8365 Query: 816 ICTVD-SRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSY 874 C V S P+ + L G ++ R + + LE+R++ DSG Y Sbjct: 8366 SCHVQGSEPIRIQWL---------KAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDY 8416 Query: 875 RCEATNVLGSSNT 887 C+A+NV GS T Sbjct: 8417 VCKASNVAGSDTT 8429 Score = 119 bits (297), Expect = 3e-26 Identities = 213/928 (22%), Positives = 345/928 (37%), Gaps = 162/928 (17%) Query: 251 NILPGELVTLTCQVNSSYPAVSSIKWLKDG----------VRLQTKTGVLHLPQAAWSDA 300 N L G V + C+V S P S+ W +G L T L + SD+ Sbjct: 7692 NGLSGSSVVMECKVYGSPPI--SVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDS 7749 Query: 301 GVYTCQAENGVGS-LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYS 359 G YTC A N GS S P+++ + VQ +L VT P + S Sbjct: 7750 GDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSV--S 7807 Query: 360 WYKN----------HVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVN 409 W+K +V LED+ + L L + +G Y C V N G + S + + Sbjct: 7808 WFKGSSELVPGDRCNVSLEDSVAE-LELFDVDTSQSGEYTCIVSNEAG-KASCTTHLYIK 7865 Query: 410 HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTS 469 P + G IL + P ++ G + S R + T+ Sbjct: 7866 APAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTP-------SQRCNITT 7918 Query: 470 GPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA--------AEV 521 S LEI D+G+Y C N+ G + +A L++ P +V Sbjct: 7919 TEKSAILEIPSSTVEDAGQYNCYIENASGKDS------CSAQILILEPPYFVKQLEPVKV 7972 Query: 522 VEGQAVTLSCRSGLSPTPDARFSWYLNGALLH---------EGPGSSLLLPAASSTDAGS 572 G + +L C+ L+ TP+ SWY L ++L+ D+G Sbjct: 7973 SVGDSASLQCQ--LAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGE 8030 Query: 573 YHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRL-DLDAAGAGAGRRGLLLCRVDSDPP 631 Y C+A + S S+ LTV P+F+ +L D+ G + C + P Sbjct: 8031 YICKAEN--SVGEVSASTFLTVQEQKLPPSFSRQLRDVQET---VGLPVVFDCAISGSEP 8085 Query: 632 ARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEA 691 + + + S P ++ + N + I G Y C A Sbjct: 8086 ISVSWYKDGKPLKDS--------------PNVQTSFLDNTATLNIFKTDRSLAGQYSCTA 8131 Query: 692 SNALGNASTSATF------NGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSW- 744 +N +G+AS+SA N + +AP + G A+ C+V+ P SW Sbjct: 8132 TNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVV-GESADFECHVT---GTQPIKVSWA 8187 Query: 745 -----FRNGVLWAQGPLET---VTLLPVARTDAALYACRILTEAGAQLSTPVL--LSVLY 794 R+G + LE +T+L V + D+ Y C + E G T L L Sbjct: 8188 KDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLI 8247 Query: 795 PPDRPK-LSALLDMGQGH-MALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQA 852 PP K LS ++ +G+ L S+P+ + + + TS + Sbjct: 8248 PPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTS---------NCEI 8298 Query: 853 KAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRG-----AWVQVSPSPELQ 907 + N+L L+VR+ G+ D+G Y C+ +N GS+ + ++ + Q + Sbjct: 8299 TFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVS 8358 Query: 908 EGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAA---------ITLTQAGAY 958 EG+ V LSC V P +W + G+ ++ S + FA+ + +G Y Sbjct: 8359 EGEYVQLSCHVQGSEP--IRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDY 8416 Query: 959 HCQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRL 1017 C+A GS TT I + AP T +D GRL + P +R+ Sbjct: 8417 VCKASNVAGSDTTKSKVTIKDKPAVAP--ATKKAAVD---GRLFFV------SEPQSIRV 8465 Query: 1018 LHGDRLVASTLQGVGGPE--------------GSSPRLHVAVAPNTLRLEIHGAMLEDEG 1063 + ++ A+ + VGG R+ + + +LEI D G Sbjct: 8466 V--EKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSG 8523 Query: 1064 VYICEASNTLGQASASADFDAQAVNVQV 1091 +Y C A N G+ ++ VN+QV Sbjct: 8524 LYRCVAFNEHGEIESN-------VNLQV 8544 Score = 116 bits (290), Expect = 2e-25 Identities = 333/1668 (19%), Positives = 588/1668 (35%), Gaps = 232/1668 (13%) Query: 106 QPEDSGSYNFRFEISEVNRWS-DVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPY 164 + +DSG Y F + ++V R S + ++ + P ++ ++G+ +D C Sbjct: 4642 EKKDSGEYTFEVQ-NDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLEC---I 4697 Query: 165 VCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMA-MSWQDHGRILRCQLSVAN 223 V + +QW D S S+K++ + + L ++ + D G + A Sbjct: 4698 VAGSHPISIQWFKDDQEISA---SEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAG 4754 Query: 224 HRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRL 283 H Q HL VK P V+ P +++ P V L V + P +IKW KD L Sbjct: 4755 HN-QCSGHLTVKEPPYFVE---KPQSQDVNPNTRVQLKALVGGTAPM--TIKWFKDNKEL 4808 Query: 284 QTKTG----------VLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEV----- 328 + L L A +D+G Y CQ N VG+ S +F+ E Sbjct: 4809 HSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKAT---LFVKEPPQFIK 4865 Query: 329 QVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH---------TLRLHL 379 + SP + Q+ T C +R SWY + + H T ++ Sbjct: 4866 KPSPVLVLRNGQSTTFECQITGTPK--IRVSWYLDGNEITAIQKHGISFIDGLATFQISG 4923 Query: 380 ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPP-----LTPV-LTAFLETQAGLVGILHC 433 A ++G Y CE +N G+ S + + V PP L PV + + + + L C Sbjct: 4924 ARVENSGTYVCEARNDAGTA-SCSIELKVKEPPTFIRELKPVEVVKYSDVE------LEC 4976 Query: 434 SVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSA 493 V P + + S S +++ T + L I + +D+GEY+C Sbjct: 4977 EVTGTPPFEVTWLKNNREIRS-------SKKYTLTDRVSVFNLHITKCDPSDTGEYQCIV 5029 Query: 494 TNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH 553 +N G+ + + I + + +S ++ +P +W + +L Sbjct: 5030 SNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILD 5089 Query: 554 EGPG---------SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFT 604 E ++L + + + +G Y C+A++ A L V P + Sbjct: 5090 EDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVE--RCYAFLLVQEPAQIVEKA 5147 Query: 605 TRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMK 664 +D+ L C V P +++ L + + S Sbjct: 5148 KSVDVTEKDPMT-----LECVVAGTPELKVKWLKDGKQIVPSR--------------YFS 5188 Query: 665 VTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQE--- 721 ++ N+ I + + ++ G Y + N G++S A + I PS T + Sbjct: 5189 MSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYL--RVLDQNIPPSFTKKLTKM 5246 Query: 722 ----GTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLETVTLLPVARTD 768 G+ ++ C VS P + WF++G L ++ + + D Sbjct: 5247 DKVLGSSIHMECKVS---GSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELED 5303 Query: 769 AALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLA 828 A Y C++ AG + +L +V PP S L+ G+ A+ TV+ + A+L Sbjct: 5304 TANYTCKVSNVAGDDACSGIL-TVKEPP-----SFLVKPGR-QQAIPDSTVEFK--AILK 5354 Query: 829 LFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN-- 886 + ++ S + E ++ L + + +G Y C TN +GS + Sbjct: 5355 GTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCT 5414 Query: 887 TSLFFQVRGAWVQ-VSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTS--- 942 T L +V+ + S ++ G + L C++ G PE W+R+ L S Sbjct: 5415 TMLLVTEPPKFVKKLEASKIVKAGDSSRLECKI-AGSPE-IRVVWFRNEHELPASDKYRM 5472 Query: 943 ------ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTG 996 A ++ ++ +G + C+AQ P +T+ I V P + +++T Sbjct: 5473 TFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVI---VKEPPVFSSFPPIVETL 5529 Query: 997 PGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHG 1056 L C + PP ++ R + S S + +A + I Sbjct: 5530 KNAEVSLECELSGTPPFEVVWYKDKRQLRS-----------SKKYKIASKNFHTSIHILN 5578 Query: 1057 AMLEDEGVYICEASNTLGQASASADFDAQAVN--VQVWPGATVREGQLVNLTCLVWTTHP 1114 D G Y C+A N +G + + V TV G+ L + P Sbjct: 5579 VDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQP 5638 Query: 1115 AQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRN 1174 + W ++ ++ + S + V + + + P A + I D Sbjct: 5639 --IFVQWLKEKEEVI-RESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENM 5695 Query: 1175 LRLTYL-----LESHG------GQLALVLCTVDSRPPAQLALSHAGRLLASSTAA--SVP 1221 L L +E G G+ + C V P + G+LL SS S Sbjct: 5696 ATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFY 5755 Query: 1222 NTLR-LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE------- 1273 N + L + + +D G Y+ ++ +G+++ + V+ + AVP Sbjct: 5756 NKISSLRILSVERQDAGTYTFQVQNNVGKSSCTA--------VVDVSDRAVPPSFTRRLK 5807 Query: 1274 ------GAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFL--VAT-------RAH 1318 GA + C A +P W+H + G +F V T + Sbjct: 5808 NTGGVLGASCILECK-VAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSD 5866 Query: 1319 AGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELA 1378 G Y+C A + G+ R A L V P + + PP ++ Sbjct: 5867 MGNYTCVAANVAGSDECR-AVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVN 5925 Query: 1379 LSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIG 1438 + L + T VA L L D+ + Y C N G S Sbjct: 5926 WFRGARELVKGDRCNIYFEDT----VAE--LELFNIDISQSGE-YTCVVSNNAGQASCTT 5978 Query: 1439 RLQVEGARVVAEPGLD--VPEGAALNLSCRLLGGPGPVG--------NSTFAWFWNDRRL 1488 RL V+ + D V G ++ L G P+ N T + N + Sbjct: 5979 RLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTL-PISVTWKKDGFNITTSEKCNI--V 6035 Query: 1489 HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGL 1548 E L + + AG Y C E G ++ L PP T + +E G Sbjct: 6036 TTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCG-ALVSTLEPPYFVTELEPLEAAVGD 6094 Query: 1549 RGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQ 1608 L C+V P +++ + G + + P + N + + +D Sbjct: 6095 SVSLQCQVAGTPEITVSWYKGDTKLRPT--------PEYRTYFTNNVATLVFNKVNINDS 6146 Query: 1609 GEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLLL 1656 GEY C A N +G+AS+ T F ++ F + L + VGL + L Sbjct: 6147 GEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTL 6194 Score = 113 bits (283), Expect = 1e-24 Identities = 195/869 (22%), Positives = 321/869 (36%), Gaps = 134/869 (15%) Query: 98 CNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVD 157 C L + L+ DSG Y I+ SD +TV E P P+++L GT V Sbjct: 7737 CALTVNMLEESDSGDYTC---IATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVT 7793 Query: 158 FNCSTPYVCLQEQVRLQW-QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILR 216 F T V + W +G + E + V LE + S Sbjct: 7794 F---TSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDS-VAELELFDVDTSQSGE---YT 7846 Query: 217 CQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW 276 C +S +A HL +K K VK L + +I G+ + L + P S+ W Sbjct: 7847 CIVSNEAGKASCTTHLYIKAPAKFVKRL---NDYSIEKGKPLILEGTFTGTPPI--SVTW 7901 Query: 277 LKDGVRLQT----------KTGVLHLPQAAWSDAGVYTCQAENGVGS--------LVSPP 318 K+G+ + K+ +L +P + DAG Y C EN G ++ PP Sbjct: 7902 KKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPP 7961 Query: 319 ISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTL--R 376 + Q+ P + + +L C ++ SWYK L ++ + R Sbjct: 7962 YFVK------QLEPV-KVSVGDSASLQCQLAGTP--EIGVSWYKGDTKLRPTTTYKMHFR 8012 Query: 377 LHLATRA-------DTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFL---ETQAG 426 ++AT D+G Y C+ +N G E S + V L P + L + G Sbjct: 8013 NNVATLVFNQVDINDSGEYICKAENSVG-EVSASTFLTVQEQKLPPSFSRQLRDVQETVG 8071 Query: 427 LVGILHCSVV-SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETD 485 L + C++ SEP++ G + SP + N+ L I + + Sbjct: 8072 LPVVFDCAISGSEPISVSWYKDGKPL--------KDSPNVQTSFLDNTATLNIFKTDRSL 8123 Query: 486 SGEYKCSATNSLGNATSTLDFHANAAR------LLISPAAEVVEGQAVTLSCRSGLSPTP 539 +G+Y C+ATN +G+A+S+ + + ++P VV G++ C ++ T Sbjct: 8124 AGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVV-GESADFECH--VTGTQ 8180 Query: 540 DARFSWYLNGALLHEGP---------GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPA 590 + SW + + G + L + D+G Y C A + S A Sbjct: 8181 PIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVN--EVGKDSCTA 8238 Query: 591 VLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSG 650 L + P+FT RL + G L RV P + + + + Sbjct: 8239 QLNIKERLIPPSFTKRLS-ETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPT---- 8293 Query: 651 GGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNA-STSATFNGQAT 709 S C ++T N L +++ + + GLY C+ SN G+A TS+ + Sbjct: 8294 ---SNC-------EITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPK 8343 Query: 710 VLAIAPSH----TLQEGTEANLTCNVSREAAGSPANFSWFRNG----------VLWAQGP 755 + H T+ EG L+C+V P W + G +A G Sbjct: 8344 KPPVFDQHLTPVTVSEGEYVQLSCHVQ---GSEPIRIQWLKAGREIKPSDRCSFSFASGT 8400 Query: 756 LETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALF 815 + L VA+ D+ Y C+ AG+ + S + D+P ++ LF Sbjct: 8401 A-VLELRDVAKADSGDYVCKASNVAGSDTTK----SKVTIKDKPAVAPATKKAAVDGRLF 8455 Query: 816 -------ICTVDSRPLALLALFHGEHL----LATSLGPQVPSHGRFQAKAEANSLKLEVR 864 I V+ +A G+ + Q+ GR + + KLE+R Sbjct: 8456 FVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIR 8515 Query: 865 ELGLGDSGSYRCEATNVLGSSNTSLFFQV 893 + DSG YRC A N G +++ QV Sbjct: 8516 DTTKTDSGLYRCVAFNEHGEIESNVNLQV 8544 Score = 72.0 bits (175), Expect = 5e-12 Identities = 94/411 (22%), Positives = 165/411 (40%), Gaps = 72/411 (17%) Query: 146 SPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLE-TLHM 204 +PV+ + G DF C +V + +++ W +R + + K++ + +LE + H+ Sbjct: 8160 APVDAVVGESADFEC---HVTGTQPIKVSWAKD--SREIR-SGGKYQ---ISYLENSAHL 8210 Query: 205 AMSWQDHGRILRCQLSVANHRAQ----SEIHLQVKYAPKGVKILLSPSGRNILPGELVTL 260 + D G + N + ++++++ + P LS + G L Sbjct: 8211 TVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEET-EGNSFKL 8269 Query: 261 TCQVNSSYPAVSSIKWLKDGVRLQ----------TKTGVLHLPQAAWSDAGVYTCQAENG 310 +V S P ++ W K+ + +Q T VL + +A +DAG+YTC+ N Sbjct: 8270 EGRVAGSQPI--TVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSND 8327 Query: 311 VGS-------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYK- 362 GS ++ P +F + ++P + E + V L C+ P +R W K Sbjct: 8328 AGSALCTSSIVIKEPKKPPVF--DQHLTPV-TVSEGEYVQLSCHVQGSEP--IRIQWLKA 8382 Query: 363 -NHVLLEDAHSHT-------LRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLT 414 + D S + L L +AD+G Y C+ NV GS+ + + + P + Sbjct: 8383 GREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVA 8442 Query: 415 PVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGP--- 471 P +A + G L VSEP + V+ + G D P T G Sbjct: 8443 PATK-----KAAVDGRLF--FVSEPQSIRVVEKTTATFIAKVG-GDPIPNVKWTKGKWRQ 8494 Query: 472 -------------NSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN 509 + +LEIRD +TDSG Y+C A N G S ++ + Sbjct: 8495 LNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVD 8545 Score = 57.4 bits (137), Expect = 1e-07 Identities = 156/754 (20%), Positives = 265/754 (35%), Gaps = 114/754 (15%) Query: 227 QSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTK 286 +S HL+VK P+ + +L + GE T C++ SY + ++W G +L+ Sbjct: 12184 KSSAHLRVK--PRVIGLLRPLKDVTVTAGETATFDCEL--SYEDIP-VEWYLKGKKLEPS 12238 Query: 287 TGVLHLPQAAWSDAGVYTCQAEN-GVGSLVSPPISLH--IFMAEVQVSPAGPILENQTV- 342 V+ + + + E+ G L + H +F+ E V P LE+QTV Sbjct: 12239 DKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKP-LEDQTVE 12297 Query: 343 -----TLVCNTPNEAPSDLRYSWYKN---------HVLLEDAHSHTLRLHLATRADTGFY 388 L C E + + W+KN + ++ D L +H T D Y Sbjct: 12298 EGATAVLECEVSRE---NAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTY 12354 Query: 389 FCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHG 448 C+ ++ + S ++VV H LT L+ + + C + E G Sbjct: 12355 TCDAKDF---KTSCNLNVVPPHVEFLRPLTD-LQVREKEMARFECELSRENAKVKWFKDG 12410 Query: 449 GHILASTSGDSDHSPRFSGTSGPNSLR-LEIRDLEETDSGEYKCSA-TNSLGNATSTLDF 506 I D ++R L I D EY C T + L+ Sbjct: 12411 AEIKKGKKYD---------IISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEE 12461 Query: 507 HANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGA---------LLHEGPG 557 A + L + EV E + L C P A WY +L EG Sbjct: 12462 EAVFTKNLAN--IEVSETDTIKLVCEVS---KPGAEVIWYKGDEEIIETGRYEILTEGRK 12516 Query: 558 SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTR-LDLDAAGAGA 616 L++ A DAG+Y+CR PSS V F ++ +L+ Sbjct: 12517 RILVIQNAHLEDAGNYNCRL--------PSSRTDGKVKVHELAAEFISKPQNLEIL---E 12565 Query: 617 GRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEI 676 G + +C + S +Q D+ +L SG R+ V K Sbjct: 12566 GEKAEFVCSI-SKESFPVQWKRDDK----TLESGDKYDVIADGKKRVLVVK--------- 12611 Query: 677 HNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAA 736 + L++ G Y+ A A+ T + ++ ++E E C V+ E A Sbjct: 12612 -DATLQDMGTYVVMVGAA--RAAAHLTVIEKLRIVVPLKDTRVKEQQEVVFNCEVNTEGA 12668 Query: 737 GSPANFSWFRNG---------VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTP 787 + WFRN ++ + + T+ + D A Y + G + + Sbjct: 12669 KA----KWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSA 12724 Query: 788 VLLSVLYPPDRPKLSALLDMG--QGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVP 845 L ++ D + L D+ + F C V+ + L +GE +VP Sbjct: 12725 ANL-IVEEEDLRIVEPLKDIETMEKKSVTFWCKVNRLNVTLKWTKNGE---------EVP 12774 Query: 846 SHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPE 905 R + + L +++ G D G Y A + L + +V+ Sbjct: 12775 FDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAEL-LIIEAPTEFVEHLEDQT 12833 Query: 906 LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQE 939 + E V SCQ+ E + +WYR+G+ ++E Sbjct: 12834 VTEFDDAVFSCQLSR---EKANVKWYRNGREIKE 12864 Score = 51.2 bits (121), Expect = 8e-06 Identities = 140/761 (18%), Positives = 258/761 (33%), Gaps = 147/761 (19%) Query: 231 HLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTK---- 286 HL V PK + L + + + E+ LTC V SS + W KDG +L+ Sbjct: 32711 HLPVSAPPKITQFLKAEASK-----EIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQ 32765 Query: 287 -------TGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPI--------SLHIFMAEV--- 328 T L + SD G Y C+ +G G + S+H ++++ Sbjct: 32766 FHYSADGTYELKINNLTESDQGEYVCEI-SGEGGTSKTNLQFMGQAFKSIHEKVSKISET 32824 Query: 329 --------------QVSPAGPI-----------LENQTVTL--VCNTPNEAPSDLRYS-- 359 + P P L++ TV+ V +A + R + Sbjct: 32825 KKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAI 32884 Query: 360 WYKN---------HVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNH 410 W K+ + L ED L +H +D+G Y C V+N GS S Sbjct: 32885 WTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSS-------- 32936 Query: 411 PPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSG 470 + A +T+A V S ++ +V S + S Sbjct: 32937 --CKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEE-----ISQKALRSEEIKMSEAKS 32989 Query: 471 PNSLRLEIRDLEETDSGEYKCSATNSL----------GNATSTLDFHANAARLLISPAAE 520 L L+ + S E K SA SL + ++ + +A S Sbjct: 32990 QEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMS 33049 Query: 521 VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH---------EGPGSSLLLPAASSTDAG 571 + EGQ + L ++ ++ D + W LNG L G +L + AS D G Sbjct: 33050 INEGQRLVL--KANIAGATDVK--WVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEG 33105 Query: 572 SYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPP 631 C ++ L+ P F ++ + G+ L C + +P Sbjct: 33106 ILTCISKTKEGIVKCQYDLTLSKELSD-APAFISQ--PRSQNINEGQNVLFTCEISGEPS 33162 Query: 632 ARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEA 691 ++ + ++ S + ++++ N+ +EI N + + G Y +A Sbjct: 33163 PEIEWFKNNLPIS--------------ISSNVSISRSRNVYSLEIRNASVSDSGKYTIKA 33208 Query: 692 SNALGNASTSATFNGQATVLAIAPSHTLQEGTEANL-----TCNVSREAAGSPANFSWFR 746 N G S +A+ V + L+ + +L + +V A+ A+FS F Sbjct: 33209 KNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFS 33268 Query: 747 NGVLWAQGPLETVTLLP----------VARTDAALYACRILTEAGAQLSTPVLLSVLYPP 796 + + ++ ++ V + ++ +T+ + S + + P Sbjct: 33269 SSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIP 33328 Query: 797 DRPKLSAL---LDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAK 853 PK+ AL + + +G + C P + G + + GRF + Sbjct: 33329 --PKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQ------EQGRFHIE 33380 Query: 854 AEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894 + L + ++ D G Y N GS + ++ +R Sbjct: 33381 NTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 33421 Score = 47.0 bits (110), Expect = 2e-04 Identities = 189/907 (20%), Positives = 305/907 (33%), Gaps = 173/907 (19%) Query: 131 TLVTVTEEPRVPTIASP---VELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFN 187 T VT E R+ + P VE+ G F + V QW+ + + + + Sbjct: 11740 TKANVTVEARLIKVEKPLYGVEVFVGETAHFEIELS----EPDVHGQWKLKGQPLTASPD 11795 Query: 188 SQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANH------RAQSEIHLQVKYAPKGV 241 + E G H+ LH CQL + A+S +L+VK P Sbjct: 11796 CEIIED-GKKHILILH------------NCQLGMTGEVSFQAANAKSAANLKVKELPL-- 11840 Query: 242 KILLSP-SGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ-------TKTGVLH-- 291 I ++P S + + C+V+ + +WLK + K G H Sbjct: 11841 -IFITPLSDVKVFEKDEAKFECEVSRE---PKTFRWLKGTQEITGDDRFELIKDGTKHSM 11896 Query: 292 -LPQAAWSDAGVYTCQAENG--VGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNT 348 + AA+ D Y +AE+ G L+ I L ++P + + + V T Sbjct: 11897 VIKSAAFEDEAKYMFEAEDKHTSGKLIIEGIRLKF------LTPLKDVTAKEKESAVF-T 11949 Query: 349 PNEAPSDLRYSWYKNHVLLEDAHSHTL----RLHLATRADTGFYFCEVQNVH--GSERSG 402 + ++R W+KN L S ++ + H T D V G Sbjct: 11950 VELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEA 12009 Query: 403 PVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSG--DSD 460 ++V+ P T L + + V IL C + G I S + +D Sbjct: 12010 KLTVLEGDPYFTGKLQDYTGVEKDEV-ILQCEISKADAPVKWFKDGKEIKPSKNAVIKAD 12068 Query: 461 HSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAE 520 R L ++ ++D G+Y C + LD +L + P Sbjct: 12069 GKKRM----------LILKKALKSDIGQYTCDCGTD--KTSGKLDIEDREIKL-VRPLHS 12115 Query: 521 VVEGQAVTLSCRSGLSPTPDARFSWYLNGALL---------HEGPGSSLLLPAASSTDAG 571 V + T + +S D +W L G L EG SL+L G Sbjct: 12116 VEVMETETARFETEISED-DIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTG 12174 Query: 572 SYHCRARDGHSASGPS-SPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVD-SD 629 +A + S++ P V+ +L P + T T AG C + D Sbjct: 12175 GVDFQAANVKSSAHLRVKPRVIGLLRPLKDVTVT-----------AGETATFDCELSYED 12223 Query: 630 PPARLQLLHK-----DRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEE 684 P L K D+VV S + + + + LE+ Sbjct: 12224 IPVEWYLKGKKLEPSDKVVPRS---------------------EGKVHTLTLRDVKLEDA 12262 Query: 685 GLYLCEASNALGNASTSATFNGQATVLAIAP--SHTLQEGTEANLTCNVSREAAGSPANF 742 G A + +A+ F + V P T++EG A L C VSRE A Sbjct: 12263 GEVQLTAKDFKTHANL---FVKEPPVEFTKPLEDQTVEEGATAVLECEVSRE----NAKV 12315 Query: 743 SWFRNGV---------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVL 793 WF+NG + A G + + + D Y C T L+V+ Sbjct: 12316 KWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTC-----DAKDFKTSCNLNVV 12370 Query: 794 YPPDRPKLSALLDM--GQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQ 851 PP L L D+ + MA F C + SR A + F G ++ ++ Sbjct: 12371 -PPHVEFLRPLTDLQVREKEMARFECEL-SRENAKVKWFKD--------GAEIKKGKKYD 12420 Query: 852 AKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQA 911 ++ L + + L D Y CE S ++ + + + + E+ E Sbjct: 12421 IISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTV-LEEEAVFTKNLANIEVSETDT 12479 Query: 912 VVLSCQVHTGVPEGTSYRWYRDGQPLQES------TSATLRFAAIT---LTQAGAYHCQA 962 + L C+V G WY+ + + E+ T R I L AG Y+C Sbjct: 12480 IKLVCEVS---KPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNC-- 12534 Query: 963 QAPGSAT 969 + P S T Sbjct: 12535 RLPSSRT 12541 Score = 47.0 bits (110), Expect = 2e-04 Identities = 105/501 (20%), Positives = 174/501 (34%), Gaps = 74/501 (14%) Query: 1162 RPITLDVLYAPRNLRLTYLLESHG---GQLALVLCTVDSRPPAQLALSHAGRLLASSTAA 1218 +P TLD +APR +T + SH GQ + V S+P A++ H G L S+ Sbjct: 32366 QPFTLD--HAPR---ITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKI 32420 Query: 1219 SVPNT---LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGA 1275 NT L LE+ D G Y + G+A+ L + G E Sbjct: 32421 HYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEV 32480 Query: 1276 PITVTCADPAAHAPTLYTWYHNGRWLQEGPAASL-SFLVATRAHAGAYSCQAQDAQGTRS 1334 P +V A + ++ + S + TR +Y A + + Sbjct: 32481 PRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAA 32540 Query: 1335 SRPAALQVLYAPQ--DAVLSSFRDSRARSMAVIQ-------CTVDSEPPAELALSHDGKV 1385 +L+ + L++ ++ RSM V + C D EP + G+V Sbjct: 32541 LEEKSLEEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQV 32600 Query: 1386 LATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQVEG 1444 L+TS+ V + ++ V A D+ Y +N G L ++ Sbjct: 32601 LSTSA--------RHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQK 32652 Query: 1445 ARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARA 1504 ARV + P + P P S A R EP Sbjct: 32653 ARVTEKAVTSPPR----------VKSPEPRVKSPEAVKSPKRVKSPEP------------ 32690 Query: 1505 QAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASL 1564 H A PT + ++ L P + F++ E S+ +A L Sbjct: 32691 ----SHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEA-----------SKEIAKL 32735 Query: 1565 TLHLGSRLVASSQ----PQGAPAEPHIHV---LASPNALRVDIEALRPSDQGEYICSASN 1617 T + S ++ + + G + + H ++ + I L SDQGEY+C S Sbjct: 32736 TCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISG 32795 Query: 1618 VLGSASTSTYFGVRALHRLHQ 1638 G++ T+ F +A +H+ Sbjct: 32796 EGGTSKTNLQFMGQAFKSIHE 32816 Score = 45.4 bits (106), Expect = 5e-04 Identities = 61/293 (20%), Positives = 99/293 (33%), Gaps = 38/293 (12%) Query: 810 GHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869 G FI V S+P A + +H G ++ + + L LE+ + Sbjct: 32388 GQNTRFILNVQSKPTAEVKWYHN--------GVELQESSKIHYTNTSGVLTLEILDCHTD 32439 Query: 870 DSGSYRCEATN------------VLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQ 917 DSG+YR TN V G T+ Q R V S PEL +A +S Sbjct: 32440 DSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSVFPELTRTEAYAVSSF 32499 Query: 918 VHTGVPE-GTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPI 976 T E +S R + + ++ +A ++ A ++ S T + + Sbjct: 32500 KKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTL 32559 Query: 977 SLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEG 1036 + + PR +T+ G C D +P + L ++++ Sbjct: 32560 AARILTKPRSMTVY------EGESARFSCDTDGEPVPTVTWLRKGQVLS----------- 32602 Query: 1037 SSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNV 1089 +S R V EI DEG Y N+ G+ A Q V Sbjct: 32603 TSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARV 32655 Score = 44.7 bits (104), Expect = 8e-04 Identities = 72/349 (20%), Positives = 129/349 (36%), Gaps = 36/349 (10%) Query: 187 NSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLS 246 NS+++ G +TL + + IL C + + L + +S Sbjct: 33079 NSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFIS 33138 Query: 247 -PSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQA 295 P +NI G+ V TC++ S P+ I+W K+ + + + V L + A Sbjct: 33139 QPRSQNINEGQNVLFTCEI-SGEPS-PEIEWFKNNLPISISSNVSISRSRNVYSLEIRNA 33196 Query: 296 AWSDAGVYTCQAENGVGS-----------LVSPPISLHIFMAEVQVSPAGPILENQTVTL 344 + SD+G YT +A+N G LV P + S G +Q+V + Sbjct: 33197 SVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGS-FSSQSVQM 33255 Query: 345 VCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRA---DTGFYFCEVQNVHGSERS 401 + + S S + ++ A + + + F + N+ E S Sbjct: 33256 SASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESS 33315 Query: 402 GPVSV---VVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGD 458 + + PP L + + G V + C+ EP + S GG + Sbjct: 33316 TSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKI-----H 33370 Query: 459 SDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFH 507 S RF + + L I D+++ D G Y S N G+ ++T++ H Sbjct: 33371 SQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIH 33419 Score = 43.1 bits (100), Expect = 0.002 Identities = 143/705 (20%), Positives = 240/705 (34%), Gaps = 123/705 (17%) Query: 426 GLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETD 485 G I C V T + G +I SP+ + +L I D++ +D Sbjct: 11133 GSSAIFECLVSPSTAITTWMKDGSNIR--------ESPKHRFIADGKDRKLHIIDVQLSD 11184 Query: 486 SGEYKC--SATNSLGNATSTLDFHANAARLL--ISPAAEVVEGQAVTLSCRSGLSPTPDA 541 +GEY C N +T+ L R + + VV+GQ + LSC L+ D Sbjct: 11185 AGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCE--LNKERDV 11242 Query: 542 RFSWYLNGALLHEGPG----------SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAV 591 W +G ++ E PG +L + A TDAG+Y + ++ S V Sbjct: 11243 --VWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKV 11300 Query: 592 LTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGG 651 + V+ R D G + C + D P D + A Sbjct: 11301 VEVI---RDWLVKPIRDQHVKPKGT---AIFACDIAKDTPNIKWFKGYDEIPAEP----- 11349 Query: 652 GCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVL 711 + + ++ + N L ++I N + E+ Y E G + G+ V Sbjct: 11350 --------NDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIE---GKRYPAKLTLGEREVE 11398 Query: 712 AIAPSH--TLQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDA 769 + P T+ E A+ +S A P W G L P Sbjct: 11399 LLKPIEDVTIYEKESASFDAEISE--ADIPG--QWKLKGELLRPSP-------------- 11440 Query: 770 ALYACRILTEAGAQLST--PVLL----SVLYPPDRPKLSALLDMGQGHMALFI----CTV 819 C I E G + T V L VLY +A+L + + + + TV Sbjct: 11441 ---TCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTV 11497 Query: 820 DSRPLALL-ALFHGEHLLATSLGPQ-VPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCE 877 R A + E + S GP + S +F A+ L + + D G Y E Sbjct: 11498 PERRQARFECVLTREANVIWSKGPDIIKSSDKFDIIADGKKHILVINDSQFDDEGVYTAE 11557 Query: 878 ATNVLGSSNTSLFF--QVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQ 935 V G ++ F +R ++ ++EG+ C++ E W+++ Sbjct: 11558 ---VEGKKTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCELS---HEKMHVVWFKNDA 11611 Query: 936 PL---------QESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRH 986 L E + L +TL Q + L++ L V A + Sbjct: 11612 KLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQVK-------ELSSTAQLKVLEADPY 11664 Query: 987 VTLTTLMDTGPGRLGLLL-CRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAV 1045 T+ T + + L C V D P + G+ +V SP+ + Sbjct: 11665 FTVKLHDKTAVEKDEITLKCEVSKDVPVKW-FKDGEEIV------------PSPKYSIKA 11711 Query: 1046 APNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQ 1090 L+I A L+D+G Y+C+ + A+ +A+ + V+ Sbjct: 11712 DGLRRILKIKKADLKDKGEYVCDCGT--DKTKANVTVEARLIKVE 11754 Score = 42.7 bits (99), Expect = 0.003 Identities = 47/173 (27%), Positives = 71/173 (41%), Gaps = 18/173 (10%) Query: 475 RLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR-----LLISPAAEVVEGQAVTL 529 +L I + + +SG Y ATN G ATST + A + + V +G V L Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRL 123 Query: 530 SCRSGLSPTPDARFSWYLNGA---------LLHEGPGSSLLLPAASSTDAGSYHCRARDG 580 R PTP +F Y +GA + EG SLL+ A D+G+Y A Sbjct: 124 QVRVTGIPTPVVKF--YRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNAT-- 179 Query: 581 HSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPAR 633 +S +S A L V P T+ + A R+ + ++++ AR Sbjct: 180 NSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDAR 232 Score = 42.7 bits (99), Expect = 0.003 Identities = 98/463 (21%), Positives = 168/463 (36%), Gaps = 59/463 (12%) Query: 1052 LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWP---GATVREGQLVNLTC- 1107 L I+ + +DEGVY E SA + ++ TV+EG+ C Sbjct: 11541 LVINDSQFDDEGVYTAEVEGK----KTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCE 11596 Query: 1108 -------LVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRL 1160 +VW + A+L + H + + VT+ D + + V L Sbjct: 11597 LSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQV------KEL 11650 Query: 1161 SRPITLDVLYAPRNLRLTYLLESHGGQLALVL-CTVDSRPPAQLALSHAGRLLASSTAAS 1219 S L VL A + ++ + + L C V P + ++ S + Sbjct: 11651 SSTAQLKVLEADPYFTVKLHDKTAVEKDEITLKCEVSKDVPVKW-FKDGEEIVPSPKYSI 11709 Query: 1220 VPNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGV-RVILAPEAAVPEGAP 1276 + LR L+++ +D+G Y C + +AN ++E RL V + + E V E A Sbjct: 11710 KADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIKVEKPLYGVEVFVGETAH 11769 Query: 1277 ITVTCADPAAHAPTLYTWYHNGRWLQEGPAASL------SFLVATRAH---AGAYSCQAQ 1327 + ++P H W G+ L P + L+ G S QA Sbjct: 11770 FEIELSEPDVHG----QWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAA 11825 Query: 1328 DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLA 1387 +A+ + + L +++ + + F A+ +C V EP L ++ Sbjct: 11826 NAKSAANLKVKELPLIFITPLSDVKVFEKDEAK----FECEVSREPKTFRWLKGTQEITG 11881 Query: 1388 TSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARV 1447 + GT H V ++A +D + Y+ A++ T G+L +EG R+ Sbjct: 11882 -DDRFELIKDGTKHSMVIKSA---AFED----EAKYMFEAEDK----HTSGKLIIEGIRL 11929 Query: 1448 -VAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLH 1489 P DV A + N WF ND+RLH Sbjct: 11930 KFLTPLKDV---TAKEKESAVFTVELSHDNIRVKWFKNDQRLH 11969 Score = 42.4 bits (98), Expect = 0.004 Identities = 42/167 (25%), Positives = 62/167 (37%), Gaps = 22/167 (13%) Query: 930 WYRDGQPLQEST-----------SATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISL 978 W+RDGQ + ST A L A+T +G Y +A TS A + Sbjct: 39 WFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVK 98 Query: 979 HVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSS 1038 + P V M G L RV P ++ + S+L EG Sbjct: 99 AETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDL 158 Query: 1039 PRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQ 1085 L +A A ED G Y A+N++G+A+++A+ Q Sbjct: 159 YSLLIAEA-----------YPEDSGTYSVNATNSVGRATSTAELLVQ 194 Score = 42.0 bits (97), Expect = 0.005 Identities = 41/190 (21%), Positives = 68/190 (35%), Gaps = 25/190 (13%) Query: 901 SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQES---------TSATLRFAAIT 951 S + EGQ +VL + T +W +G L S + TL + Sbjct: 33045 STQMSINEGQRLVLKANI----AGATDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQAS 33100 Query: 952 LTQAGAYHCQAQAP-GSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSD 1010 G C ++ G +S +S AP ++ + G+ L C + + Sbjct: 33101 HRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGE 33160 Query: 1011 PPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEAS 1070 P ++ + P S + ++ + N LEI A + D G Y +A Sbjct: 33161 PSPEIEWFKNNL-----------PISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAK 33209 Query: 1071 NTLGQASASA 1080 N GQ SA+A Sbjct: 33210 NFRGQCSATA 33219 Score = 41.2 bits (95), Expect = 0.009 Identities = 44/193 (22%), Positives = 77/193 (39%), Gaps = 31/193 (16%) Query: 521 VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEG--PG---------SSLLLPAASSTD 569 V+EG T P P+ SW+ +G ++ PG + L +PA + + Sbjct: 17 VLEGSTATFEAHISGFPVPEV--SWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKAN 74 Query: 570 AGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSD 629 +G Y +A +G + +S A L V P F RL G+ R L RV Sbjct: 75 SGRYSLKATNGSGQA--TSTAELLVKAETAPPNFVQRLQSMTVRQGSQVR--LQVRVTGI 130 Query: 630 PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLC 689 P ++ + +SL ++++ +L + I E+ G Y Sbjct: 131 PTPVVKFYRDGAEIQSSLD--------------FQISQEGDLYSLLIAEAYPEDSGTYSV 176 Query: 690 EASNALGNASTSA 702 A+N++G A+++A Sbjct: 177 NATNSVGRATSTA 189 Score = 41.2 bits (95), Expect = 0.009 Identities = 30/111 (27%), Positives = 51/111 (45%), Gaps = 11/111 (9%) Query: 398 SERSGPVSVVVNHPP----LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILA 453 SE S PV+++ + P L+ + + L +AG L +V +P+ T+ G +L Sbjct: 19278 SEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLK 19337 Query: 454 STSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTL 504 G R N LE+ + DSG+Y +A NS G+ ++T+ Sbjct: 19338 PAEGIKMAMQR-------NLCTLELFSVNRKDSGDYTITAENSSGSKSATI 19381 Score = 40.4 bits (93), Expect = 0.015 Identities = 44/189 (23%), Positives = 75/189 (39%), Gaps = 26/189 (13%) Query: 721 EGTEANLTCNVSREAAGSPA-NFSWFRNGVLWAQGPLETV-----------TLLPVARTD 768 EG+ A ++S G P SWFR+G + + L V T+ V + + Sbjct: 19 EGSTATFEAHIS----GFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKAN 74 Query: 769 AALYACRILTEAGAQLSTPVLL--SVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLAL 826 + Y+ + +G ST LL + PP+ + + + QG V P + Sbjct: 75 SGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPV 134 Query: 827 LALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN 886 + + G ++ S FQ E + L + E DSG+Y ATN +G + Sbjct: 135 VKFYRD--------GAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRAT 186 Query: 887 TSLFFQVRG 895 ++ V+G Sbjct: 187 STAELLVQG 195 Score = 40.0 bits (92), Expect = 0.019 Identities = 70/336 (20%), Positives = 133/336 (39%), Gaps = 46/336 (13%) Query: 68 QVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSD 127 +V+ + D +++E GR E + R+ L++++ ED+G+YN R S + Sbjct: 12492 EVIWYKGDEEIIET---GRYEILTEGRKRI--LVIQNAHLEDAGNYNCRLPSSRTDGKVK 12546 Query: 128 VKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFN 187 V +P+ +E+LEG + +F CS +E +QW+ D + Sbjct: 12547 VHELAAEFISKPQ------NLEILEGEKAEFVCSIS----KESFPVQWKRDDKTLE---S 12593 Query: 188 SQKFEPTGVGHLETLHMA-MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLS 246 K++ G L + + QD G + V A++ HL V + ++I++ Sbjct: 12594 GDKYDVIADGKKRVLVVKDATLQDMGTYV-----VMVGAARAAAHLTV---IEKLRIVVP 12645 Query: 247 PSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDG----------VRLQTKTGVLHLPQAA 296 + + V C+VN+ + KW ++ + + L + A Sbjct: 12646 LKDTRVKEQQEVVFNCEVNTE---GAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAH 12702 Query: 297 WSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQ-VSPAGPI--LENQTVTLVCNTPNEAP 353 D Y N G V +L + +++ V P I +E ++VT C N Sbjct: 12703 LDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKV-NRLN 12761 Query: 354 SDLRYSWYKNHVLLEDAHSHTL--RLHLATRADTGF 387 L+++ V ++ S+ + H+ T D GF Sbjct: 12762 VTLKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGF 12797 Score = 38.9 bits (89), Expect = 0.043 Identities = 52/246 (21%), Positives = 97/246 (39%), Gaps = 59/246 (23%) Query: 48 DVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEAR-FRGRTEFMGNPEHRVC------NL 100 D+EVP+ YSG+ + + P+ +E + + E N ++ + NL Sbjct: 2275 DIEVPES--------YSGELECI---VSPENIEGKWYHNDVELKSNGKYTITSRRGRQNL 2323 Query: 101 LLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNC 160 +KD+ ED G Y+F D K T + +PR P+ +L+G C Sbjct: 2324 TVKDVTKEDQGEYSFVI---------DGKKTTCKLKMKPR------PIAILQGLSDQKVC 2368 Query: 161 STPYVCLQEQVRLQ-----WQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRIL 215 V L+ +V L+ W + Q+ +P+ + +H+ + Q H ++ Sbjct: 2369 EGDIVQLEVKVSLESVEGVWMK---------DGQEVQPS-----DRVHIVIDKQSHMLLI 2414 Query: 216 R--CQLSVANHR---AQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPA 270 + N+ + + + V ++ N++ G L C+V S P Sbjct: 2415 EDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLKDVNVIEGTKAVLECKV--SVPD 2472 Query: 271 VSSIKW 276 V+S+KW Sbjct: 2473 VTSVKW 2478 Score = 38.9 bits (89), Expect = 0.043 Identities = 38/165 (23%), Positives = 63/165 (38%), Gaps = 19/165 (11%) Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTA---ASVPNTLRLELRGPQPRDEGFYSCS 1242 G+ A + C + RP + G+ L S +S T L + + DEG Y+C Sbjct: 30547 GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCI 30606 Query: 1243 ARSPLGQANTSLELRLEGVRVI-----LAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN 1297 A + +G+ TS +L L+ L + G+ + + P + TW+H Sbjct: 30607 ATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAM-TWFHG 30665 Query: 1298 GRWLQEGPAASLSFL----------VATRAHAGAYSCQAQDAQGT 1332 + LQ ++ V + HAG Y Q + GT Sbjct: 30666 QKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGT 30710 Score = 38.5 bits (88), Expect = 0.057 Identities = 78/325 (24%), Positives = 111/325 (34%), Gaps = 54/325 (16%) Query: 252 ILPGELVTLTCQVNSSYPAVSSIKWLKDGVR-----------LQTKTGVLHLPQAAWSDA 300 IL G VT C++ S YP + I W KDG R LQ L +P D Sbjct: 1302 ILEGMGVTFHCKM-SGYP-LPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDE 1359 Query: 301 GVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSW 360 G+YT A N G+ I ++ V PA P L T + S S Sbjct: 1360 GIYTAFASNIKGNA--------ICSGKLYVEPAAP-LGAPTYIPTLEPVSRIRSLSPRSV 1410 Query: 361 YKNHVLLEDAHSHTLRLHLA----TRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPV 416 ++ + + A R+ A R G E PV V L PV Sbjct: 1411 SRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQLERLYKPVFV------LKPV 1464 Query: 417 LTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP--RFSGTSGPNSL 474 LE Q + VV P+ H G + + D H + GT Sbjct: 1465 SFKCLEGQTARFDL---KVVGRPMPETFWFHDGQQIVN---DYTHKVVIKEDGTQS---- 1514 Query: 475 RLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA-------AEVVEGQAV 527 L I +DSGE+ A N G ++ ++ A + P + EG + Sbjct: 1515 -LIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRL 1573 Query: 528 TLSCRSGLSPTPDARFSWYLNGALL 552 + R+ +P PD W N ++ Sbjct: 1574 EMKVRATGNPNPD--IVWLKNSDII 1596 Score = 37.7 bits (86), Expect = 0.096 Identities = 70/362 (19%), Positives = 130/362 (35%), Gaps = 49/362 (13%) Query: 1299 RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQG-TRSSRPAALQVLYAPQDAVLSSFRDS 1357 R+ G +L+ A+ G +C ++ +G + L + A +S R Sbjct: 33084 RYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQ 33143 Query: 1358 RARS--MAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQD 1415 + C + EP E+ + ++ SS V + +RN L++++ Sbjct: 33144 NINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVS--------ISRSRNVYSLEIRN 33195 Query: 1416 VPAGDD-TYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVP---------EGAALNLSC 1465 D Y A+N G S L V +V EP +V +G+ + S Sbjct: 33196 ASVSDSGKYTIKAKNFRGQCSATASLMV--LPLVEEPSREVVLRTSGDTSLQGSFSSQSV 33253 Query: 1466 RLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHV-ARAQAGMYHCLAELPTGA----- 1519 ++ S+F+ A + + F + A++ + M E+ + + Sbjct: 33254 QMSASKQEASFSSFS------SSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGIS 33307 Query: 1520 -----AASAPVMLRVLY---PPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSR 1571 +S ML+ PPK + + + G + C EP +T G R Sbjct: 33308 NMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGR 33367 Query: 1572 LVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631 + SQ QG H+ + + + I ++ D G Y S N GS S + +R Sbjct: 33368 KI-HSQEQG-----RFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 33421 Query: 1632 AL 1633 ++ Sbjct: 33422 SI 33423 Score = 37.7 bits (86), Expect = 0.096 Identities = 62/317 (19%), Positives = 121/317 (38%), Gaps = 42/317 (13%) Query: 1226 LELRGPQPRDEGFYSCSARSPLGQANTSLELRL-----EGVRVILAPEAA-VPEGAPITV 1279 L ++ RDEG +C +++ G +L L + I P + + EG + Sbjct: 33094 LTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLF 33153 Query: 1280 TCADPAAHAPTLYTWYHNGRWLQEGPAASLS---------FLVATRAHAGAYSCQAQDAQ 1330 TC +P + W+ N + S+S A+ + +G Y+ +A++ + Sbjct: 33154 TCEISGEPSPEI-EWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFR 33212 Query: 1331 GTRSSRPAALQVL----YAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVL 1386 G + S A+L VL ++ VL + D+ + Q S E + S Sbjct: 33213 G-QCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSS 33271 Query: 1387 ATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGA- 1445 A+S AS + + ++++ ++ + + L S S + + + G Sbjct: 33272 ASSMTEMKFASMSAQ---SMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIP 33328 Query: 1446 -RVVAEPG-LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA-----------EP 1492 ++ A P + + EG L ++C G P P W R++H+ + Sbjct: 33329 PKIEALPSDISIDEGKVLTVACAFTGEPTP----EVTWSCGGRKIHSQEQGRFHIENTDD 33384 Query: 1493 VPTLAFTHVARAQAGMY 1509 + TL V + G+Y Sbjct: 33385 LTTLIIMDVQKQDGGLY 33401 Score = 37.4 bits (85), Expect = 0.13 Identities = 62/269 (23%), Positives = 91/269 (33%), Gaps = 49/269 (18%) Query: 1225 RLELRGPQ--PRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCA 1282 R LR P P DEG Y+ A + G A S +L + E A P GAP + Sbjct: 1346 RASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYV---------EPAAPLGAPTYIPTL 1396 Query: 1283 DPAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTR--SSRPAAL 1340 +P + +L + R + P ++ + A A+ + G R + + L Sbjct: 1397 EPVSRIRSL-----SPRSVSRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQL 1451 Query: 1341 QVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDG---------KVLATSSG 1391 + LY P + A V P E HDG KV+ G Sbjct: 1452 ERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDG 1511 Query: 1392 VHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEP 1451 SL + V P+ + AQN G S L VE +P Sbjct: 1512 TQSL---------------IIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKP 1556 Query: 1452 -------GLDVPEGAALNLSCRLLGGPGP 1473 +++ EG+ L + R G P P Sbjct: 1557 MFVEKLKNVNIKEGSRLEMKVRATGNPNP 1585 Score = 36.6 bits (83), Expect = 0.21 Identities = 30/122 (24%), Positives = 51/122 (41%), Gaps = 15/122 (12%) Query: 849 RFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE 908 +F+ + + L V+ L D G+YR + S+ ++ + AW + L+E Sbjct: 8702 KFEISIDGDRHTLRVKNCQLKDQGNYRLVCGPHIASAKLTV---IEPAWERHLQDVTLKE 8758 Query: 909 GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQ---------ESTSATLRFAAITLTQAGAYH 959 GQ ++CQ VP S W+R+G+ L+ E L A + G Y Sbjct: 8759 GQTCTMTCQF--SVPNVKS-EWFRNGRILKPQGRHKTEVEHKVHKLTIADVRAEDQGQYT 8815 Query: 960 CQ 961 C+ Sbjct: 8816 CK 8817 Score = 36.2 bits (82), Expect = 0.28 Identities = 61/294 (20%), Positives = 103/294 (35%), Gaps = 49/294 (16%) Query: 286 KTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGP-----ILENQ 340 K +L + + + D GVYT + E S +F+ +++ P + E + Sbjct: 11537 KKHILVINDSQFDDEGVYTAEVEG-------KKTSARLFVTGIRLKFMSPLEDQTVKEGE 11589 Query: 341 TVTLVCNTPNEAPSDLRYSWYKNHVLLE---------DAHSHTLRLHLATRADTGFYFCE 391 T T VC +E + W+KN L + +H L + T D + Sbjct: 11590 TATFVCELSHEK---MHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQ 11646 Query: 392 VQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHI 451 V+ + + + + V+ P T L + + L C V S+ + G I Sbjct: 11647 VKELSSTAQ---LKVLEADPYFTVKLHDKTAVEKDEI-TLKCEV-SKDVPVKWFKDGEEI 11701 Query: 452 LASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAA 511 + S P++S + L+I+ + D GEY C A T++ A Sbjct: 11702 VPS--------PKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVE-----A 11748 Query: 512 RLLISP----AAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLL 561 RL+ EV G+ PD W L G L P ++ Sbjct: 11749 RLIKVEKPLYGVEVFVGETAHFEIELS---EPDVHGQWKLKGQPLTASPDCEII 11799 Score = 36.2 bits (82), Expect = 0.28 Identities = 43/209 (20%), Positives = 79/209 (37%), Gaps = 32/209 (15%) Query: 718 TLQEGTEANLTCNVSREAAGSPA-NFSWFRNGV---------LWAQGPLETVTLLPVART 767 T + G A L+C + G P + W+R G + + G T+T++ + Sbjct: 30543 TTKLGEAAQLSCQI----VGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQE 30598 Query: 768 DAALYACRILTEAG-AQLSTPVLLSVL--YPPDRPKLSALLDMGQGHMALFICTVDSRPL 824 D +Y C E G + S+ +LL + P P + L + + RP+ Sbjct: 30599 DEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYI-GRPV 30657 Query: 825 ALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGS 884 + FHG+ LL S + + + N + +G Y+ + +NV G+ Sbjct: 30658 PAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKT-------HAGKYKVQLSNVFGT 30710 Query: 885 SNTSLFFQVRGAWVQVSPSPELQEGQAVV 913 + L V++ P+ G V+ Sbjct: 30711 VDAILD-------VEIQDKPDKPTGPIVI 30732 Score = 36.2 bits (82), Expect = 0.28 Identities = 32/148 (21%), Positives = 59/148 (39%), Gaps = 12/148 (8%) Query: 362 KNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFL 421 + + + D +HTL + + D G Y C N G + ++ P P Sbjct: 30577 RKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGY-PLK 30635 Query: 422 ETQAGLVGI---LHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEI 478 E G VG LH + P+ + HG +L +S + + + L + Sbjct: 30636 EKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLL-------QNSENITIENTEHYTHLVM 30688 Query: 479 RDLE-ETDSGEYKCSATNSLGNATSTLD 505 ++++ +T +G+YK +N G + LD Sbjct: 30689 KNVQRKTHAGKYKVQLSNVFGTVDAILD 30716 Score = 35.8 bits (81), Expect = 0.37 Identities = 57/231 (24%), Positives = 81/231 (35%), Gaps = 23/231 (9%) Query: 672 LRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNV 731 LR+ + P E+EG+Y ASN GNA S L + P+ L T V Sbjct: 1349 LRIPVVLP--EDEGIYTAFASNIKGNAICSGK-------LYVEPAAPLGAPTYIPTLEPV 1399 Query: 732 SREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLS 791 SR + SP + S R+ + + + + P + A + R L E L Sbjct: 1400 SRIRSLSPRSVS--RSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDES-----QLE 1452 Query: 792 VLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQ 851 LY P +G A F V RP+ FH + +V Sbjct: 1453 RLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKV------- 1505 Query: 852 AKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSP 902 E + L + DSG + A N G S+ S+ V QV P Sbjct: 1506 VIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKP 1556 Score = 35.8 bits (81), Expect = 0.37 Identities = 41/171 (23%), Positives = 67/171 (39%), Gaps = 34/171 (19%) Query: 255 GELVTLTCQVNSSYPAVSSIKWLKDGVRL----------QTKTGVLHLPQAAWSDAGVYT 304 GE L+CQ+ + IKW + G L +T L + D GVYT Sbjct: 30547 GEAAQLSCQIVGR--PLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYT 30604 Query: 305 CQAENGVGSLVSPPISLHIFMAEVQVSPAGPILE------NQTVTL-VCNTPNEAPSDLR 357 C A N VG + + S + A Q P P+ E T+ L V P+ Sbjct: 30605 CIATNEVGEVETS--SKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPA--- 30659 Query: 358 YSWYKNHVLLEDA----------HSHTLRLHLATRADTGFYFCEVQNVHGS 398 +W+ LL+++ ++H + ++ + G Y ++ NV G+ Sbjct: 30660 MTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGT 30710 Score = 34.7 bits (78), Expect = 0.82 Identities = 32/128 (25%), Positives = 50/128 (39%), Gaps = 25/128 (19%) Query: 408 VNHPPLT--PVLTAFLETQAGL-VGILHCSVVSEPLATLV---------LSHGGHILAST 455 V H P++ P +T FL+ +A + L C V S L L GH Sbjct: 32709 VQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHY 32768 Query: 456 SGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLI 515 S D + L+I +L E+D GEY C + G + + L F A + + Sbjct: 32769 SADGTYE-------------LKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIH 32815 Query: 516 SPAAEVVE 523 +++ E Sbjct: 32816 EKVSKISE 32823 Score = 33.9 bits (76), Expect = 1.4 Identities = 25/113 (22%), Positives = 48/113 (42%), Gaps = 9/113 (7%) Query: 782 AQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLG 841 A++ PV + V PP + + +G C + P + + ++ + +S+ Sbjct: 930 ARVPAPVEIPVT-PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSID 988 Query: 842 PQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894 FQ ++ +L +RE DSG + C A N G+ +TS + V+ Sbjct: 989 --------FQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 1033 Score = 33.9 bits (76), Expect = 1.4 Identities = 26/90 (28%), Positives = 49/90 (54%), Gaps = 18/90 (20%) Query: 252 ILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQT--------KTGV--LHLPQAAWSDAG 301 ++ GE VTL C + S YP+ ++ W ++ ++++ ++G+ L + +A D+G Sbjct: 954 VIEGESVTLECHI-SGYPS-PTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSG 1011 Query: 302 VYTCQAENGVGSLVSPPISLHIFMAEVQVS 331 +TC A N G+ +S ++A VQVS Sbjct: 1012 RFTCSAVNEAGT-----VSTSCYLA-VQVS 1035 Score = 33.9 bits (76), Expect = 1.4 Identities = 22/74 (29%), Positives = 32/74 (43%), Gaps = 13/74 (17%) Query: 273 SIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLH 322 +I W+KDG L+ T V LH+ + D G YT A N G+ +L Sbjct: 24342 NISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATE---NLS 24398 Query: 323 IFMAEVQVSPAGPI 336 + + E P GP+ Sbjct: 24399 VIVLEKPGPPVGPV 24412 Score = 33.9 bits (76), Expect = 1.4 Identities = 47/218 (21%), Positives = 74/218 (33%), Gaps = 33/218 (15%) Query: 1070 SNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL 1129 ++T+ +F N + G VR G + T HP + TWY+ GQ+ Sbjct: 31680 TDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTI-------TVHP-EPHVTWYKSGQKIK 31731 Query: 1130 DA--------------HSIPLPNVTVRDATSY----RCGVGPPGRAPRLS---RPITLDV 1168 + + + +VT D Y R G +L+ P D Sbjct: 31732 PGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDS 31791 Query: 1169 LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT----L 1224 P RL E GQ V PP L G+ L+ + + Sbjct: 31792 TLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYY 31851 Query: 1225 RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVR 1262 L +R P D G+Y +A + G + L++E +R Sbjct: 31852 ALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVERLR 31889 Score = 33.1 bits (74), Expect = 2.4 Identities = 30/119 (25%), Positives = 46/119 (38%), Gaps = 9/119 (7%) Query: 1513 AELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRL 1572 A++ A APV + V PP + + V G L+C + P ++T + Sbjct: 924 AKVTETARVPAPVEIPVT-PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQ 982 Query: 1573 VASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631 + SS + R+ I D G + CSA N G+ STS Y V+ Sbjct: 983 IESSID--------FQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 1033 Score = 33.1 bits (74), Expect = 2.4 Identities = 38/171 (22%), Positives = 68/171 (39%), Gaps = 35/171 (20%) Query: 272 SSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISL 321 +++ W KDG L+ T V L + +A+ D G Y N GS ++ PI++ Sbjct: 25424 ATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGS-ITVPITI 25482 Query: 322 HIFMAEVQVSPAGPI----LENQTVTLVCNTPN------------EAPSDLRYSWYKNHV 365 + + P GPI + ++T+ N P E +W H+ Sbjct: 25483 IVL---DRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTW---HI 25536 Query: 366 LLEDAHSHTLRL-HLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTP 415 + + ++++ L T ++ F C +N +G S VV P +P Sbjct: 25537 VSQAVARTSIKIVRLTTGSEYQFRVC-AENRYGKSSYSESSAVVAEYPFSP 25586 Score = 32.7 bits (73), Expect = 3.1 Identities = 43/195 (22%), Positives = 74/195 (37%), Gaps = 22/195 (11%) Query: 767 TDAALYACRILTE----AGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSR 822 T+ A+Y R++ E G + T + PP P L D+ Q +L + Sbjct: 24180 TEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEHD 24239 Query: 823 PLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVL 882 G +L + Q ++ AE+ V L G +R +A N Sbjct: 24240 G--------GSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEK 24291 Query: 883 GSSNTSLF-FQVRGAWVQVSPSPEL-------QEGQAVVLSCQVHTGVPEGTSYRWYRDG 934 G S+ + V + + PS +L Q G+ + + V G P + W +DG Sbjct: 24292 GKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPV-IGRPR-PNISWVKDG 24349 Query: 935 QPLQESTSATLRFAA 949 +PL+++T + A Sbjct: 24350 EPLKQTTRVNVEETA 24364 Score = 32.7 bits (73), Expect = 3.1 Identities = 38/149 (25%), Positives = 56/149 (37%), Gaps = 16/149 (10%) Query: 362 KNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPP-----LTPV 416 K + D + L ++ T D Y +N +G + V HPP L P+ Sbjct: 31737 KKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPM 31796 Query: 417 ---LTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILA-STSGDSDHSPRFSGTSGPN 472 L A E Q G V P TL G L+ + + H G + Sbjct: 31797 FKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHE-------GLD 31849 Query: 473 SLRLEIRDLEETDSGEYKCSATNSLGNAT 501 L IRD D+G Y+ +ATN+ G+ + Sbjct: 31850 YYALHIRDTLPEDTGYYRVTATNTAGSTS 31878 Score = 32.7 bits (73), Expect = 3.1 Identities = 27/74 (36%), Positives = 36/74 (48%), Gaps = 9/74 (12%) Query: 434 SVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSA 493 +V S+P A + H G L +S ++ TSG L LEI D DSG Y+ Sbjct: 32396 NVQSKPTAEVKWYHNGVELQESS-----KIHYTNTSGV--LTLEILDCHTDDSGTYRAVC 32448 Query: 494 TNSLGNAT--STLD 505 TN G A+ +TLD Sbjct: 32449 TNYKGEASDYATLD 32462 Score = 32.3 bits (72), Expect = 4.1 Identities = 23/86 (26%), Positives = 35/86 (40%), Gaps = 2/86 (2%) Query: 472 NSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLI--SPAAEVVEGQAVTL 529 N L IRD+ DS A N G +S A +L+ +VV + T+ Sbjct: 2132 NVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTM 2191 Query: 530 SCRSGLSPTPDARFSWYLNGALLHEG 555 + + P + WY +G +HEG Sbjct: 2192 ATFECETSEPFVKVKWYKDGMEVHEG 2217 Score = 32.3 bits (72), Expect = 4.1 Identities = 24/100 (24%), Positives = 43/100 (43%), Gaps = 13/100 (13%) Query: 849 RFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQV-----------RGAW 897 ++ +++ +L + + D Y A N G + V R + Sbjct: 31738 KYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMF 31797 Query: 898 VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL 937 ++ + E QEGQ+V +V +G+P T +W +DGQPL Sbjct: 31798 KRLLANAECQEGQSVCFEIRV-SGIPPPT-LKWEKDGQPL 31835 Score = 32.3 bits (72), Expect = 4.1 Identities = 27/118 (22%), Positives = 53/118 (44%), Gaps = 12/118 (10%) Query: 1332 TRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDS--EPPAELALSHDGKVLATS 1389 TR + P A + + + + +++ +D+ S +V + V + EP + DGK + T Sbjct: 32837 TRKTEPKAPEPI-SSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAI-TQ 32894 Query: 1390 SGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQVEGAR 1446 G + L+ G L++ D Y CT +N GS+S+ +L ++ + Sbjct: 32895 GGKYKLSEDKG-------GFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIK 32945 Score = 32.0 bits (71), Expect = 5.3 Identities = 32/156 (20%), Positives = 60/156 (38%), Gaps = 15/156 (9%) Query: 48 DVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQP 107 DV + +G T +S + ++++ + R +TE EH+V L + D++ Sbjct: 8753 DVTLKEGQTCTMTCQFSVPNVKSEWFRNGRILKPQGRHKTEV----EHKVHKLTIADVRA 8808 Query: 108 EDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCL 167 ED G Y ++E E + ++ + T+ R+ I + E F C + Sbjct: 8809 EDQGQYTCKYEDLETSAELRIEAEPIQFTK--RIQNIV----VSEHQSATFECEVSF--- 8859 Query: 168 QEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLH 203 + + W + P F G H T+H Sbjct: 8860 -DDAIVTWY-KGPTELTESQKYNFRNDGRCHYMTIH 8893 Score = 32.0 bits (71), Expect = 5.3 Identities = 38/158 (24%), Positives = 58/158 (36%), Gaps = 13/158 (8%) Query: 1473 PVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVML----- 1527 P G AW R+ + V L FT + G Y + A S P Sbjct: 16055 PTGTKKEAW----RQCNKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCD 16110 Query: 1528 --RVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEP 1585 R PP + F+E E G + ++ P +LT ++ + + Sbjct: 16111 CQRPDMPPSID-LKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNK-EPVLYDT 16168 Query: 1586 HIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSAS 1623 H++ L + + I R SD G Y +A N LG+AS Sbjct: 16169 HVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTAS 16206 Score = 32.0 bits (71), Expect = 5.3 Identities = 17/40 (42%), Positives = 23/40 (57%), Gaps = 1/40 (2%) Query: 1060 EDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVRE 1099 EDEGVY C A+N +G+ S+ QA Q PG ++E Sbjct: 30598 EDEGVYTCIATNEVGEVETSSKLLLQA-TPQFHPGYPLKE 30636 Score = 31.2 bits (69), Expect = 9.0 Identities = 16/53 (30%), Positives = 27/53 (50%), Gaps = 10/53 (18%) Query: 271 VSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTCQAENGVGS 313 V ++ W KDG ++ + L +P++ +DAG+YT EN +GS Sbjct: 14415 VPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGS 14467 Score = 31.2 bits (69), Expect = 9.0 Identities = 21/81 (25%), Positives = 33/81 (40%), Gaps = 7/81 (8%) Query: 423 TQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLE 482 T+ G L C +V PL + G L S ++ +S + L + E Sbjct: 30544 TKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ-------SRKYKMSSDGRTHTLTVMTEE 30596 Query: 483 ETDSGEYKCSATNSLGNATST 503 + D G Y C ATN +G ++ Sbjct: 30597 QEDEGVYTCIATNEVGEVETS 30617 >gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] Length = 4391 Score = 185 bits (470), Expect = 3e-46 Identities = 415/1794 (23%), Positives = 636/1794 (35%), Gaps = 327/1794 (18%) Query: 18 QASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSADPK 77 Q G VQG G CL P P VEV + + R VS S Sbjct: 1652 QCGPGYVGNPSVQG--GQCL--PETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHY 1707 Query: 78 LVEARFRGRTEFMGNPE-HRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVT 136 +R GR G + H+ L +QP D+G Y + S + + VT Sbjct: 1708 FYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAE---LLVT 1764 Query: 137 EEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQ----VRLQW----QGQDPARSVTFNS 188 E P P I VE V ++C + L W G+ P R++ FN Sbjct: 1765 EAPSKP-ITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFN- 1822 Query: 189 QKFEPTGVGHLETLHMAMSWQDHGRILRCQLSV-ANHRAQSEIHLQVKYAPKGVKILLSP 247 G L ++ +S D G + ++ A + + +H+Q + + P Sbjct: 1823 --------GILTIRNVQLS--DAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHP 1872 Query: 248 SGRNILPGELVTLTCQVNSSYPAVSSIKWL-KDGVRLQTKT----GVLHLPQAAWSDAGV 302 + PG+L C S +++W G +L K G+L LP +D Sbjct: 1873 PQLTVQPGQLAEFRCSATGS--PTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQ 1930 Query: 303 YTCQAENGVGSLVSPPISLHIFMA---EVQVSP-AGPILENQTVTLVCNTPNEAPSDLRY 358 Y C+A + G V+ + LH+ VQVSP + +TV L C + + Sbjct: 1931 YLCRAHSSAGQQVARAV-LHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATI-- 1987 Query: 359 SWYKNHVLL------EDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVN--- 409 +W K L E TL + T AD GFY C + G+ ++ VV++ Sbjct: 1988 TWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASD 2047 Query: 410 -HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGT 468 PP + ++ G L+C V A + G L P + Sbjct: 2048 ASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSL----------PPHTQV 2097 Query: 469 SGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD---FHANAARLLISP-------- 517 G RL + + DSGEY C N G +++ H + +P Sbjct: 2098 HGS---RLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPI 2154 Query: 518 -----AAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALL---HEGPGSSLLLPAASSTD 569 ++ V EGQ + L+C + A+ +W+ G L H+ GS L L + D Sbjct: 2155 RIEPSSSHVAEGQTLDLNC--VVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPAD 2212 Query: 570 AGSYHCRARDGHSASGPSSPAVLTVLYPP--RQPTFTTRLDLDAAGAGAGRRGLLLCRVD 627 +G Y C SGP +VL + P R++ ++ G+ L C V Sbjct: 2213 SGEYVCHV---VGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVA 2269 Query: 628 SDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLY 687 A++ + GG P + R+ I + G Y Sbjct: 2270 GQAHAQVTWYKR-----------------GGSLPARHQVRGS---RLYIFQASPADAGQY 2309 Query: 688 LCEASNALGNASTSATFNGQATVLA----------IAPSHT-LQEGTEANLTCNVSREAA 736 +C ASN + + T Q LA I PS + + EG +L C V + Sbjct: 2310 VCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQ-- 2367 Query: 737 GSPANFSWFRNG---VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVL 793 S A +W + G + Q + L + D+ Y CR+L + L VL+++ Sbjct: 2368 -SHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVL-GSSVPLEASVLVTIE 2425 Query: 794 YPPDRPKL----SALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSH-- 847 P L + ++ +A + + L L L G+ QV H Sbjct: 2426 PAGSVPALGVTPTVRIESSSSQVA------EGQTLDLNCLVAGQ------AHAQVTWHKR 2473 Query: 848 -GRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR----GAWVQ--- 899 G A+ + + +L + ++ DSG Y C G+ S+ ++ G+ Q Sbjct: 2474 GGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVA 2533 Query: 900 -----VSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL---QESTSATLRFAAIT 951 S S L G + L+C V + P + WY+ G L + + LR +T Sbjct: 2534 YPVRIESSSASLANGHTLDLNCLVASQAPH--TITWYKRGGSLPSRHQIVGSRLRIPQVT 2591 Query: 952 LTQAGAYHCQ-AQAPGSATTSLAAPI----SLHVSYAPRHVTLTTLMDT-GPGRLGLLLC 1005 +G Y C + GS TSL I S HV + + + T G+ L C Sbjct: 2592 PADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNC 2651 Query: 1006 RVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVY 1065 V P A ++ +G GS P H + L +H + D G Y Sbjct: 2652 VVARQPQA---------IITWYKRG-----GSLPSRH---QTHGSHLRLHQMSVADSGEY 2694 Query: 1066 ICEASNTLGQASASADFD-AQAVNVQVWPGAT-----------VREGQLVNLTCLVWTTH 1113 +C A+N + AS + + PG++ V EG+ ++L C+V Sbjct: 2695 VCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQA 2754 Query: 1114 PAQLTYTWYQDGQQRLDAHS-----IPLPNVTVRDATSYRCGV----GP----------- 1153 AQ+ TW++ G H + L +V+ D+ Y C V GP Sbjct: 2755 HAQV--TWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEA 2812 Query: 1154 ----------PGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQL 1203 PG AP PI ++ P + R+ GQ + C V + AQ+ Sbjct: 2813 SGSSAVHVPAPGGAP----PIRIE----PSSSRVA------EGQTLDLKCVVPGQAHAQV 2858 Query: 1204 ALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE--GV 1261 G L + P L L P D G YSC G S+ + +E Sbjct: 2859 TWHKRGGNLPARHQVHGP---LLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSP 2915 Query: 1262 RVILAPEAAVP-----------EGAPITVTCADPA-AHAPTLYTWYHNGRWL---QEGPA 1306 I AP A P EG + + C P AHA TWY G L + Sbjct: 2916 GPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQV--TWYKRGGSLPARHQTHG 2973 Query: 1307 ASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR-DSRARSMAVI 1365 + L + + A +G Y C+A A G + A+ V P + SS+R S S+ Sbjct: 2974 SQLRLHLVSPADSGEYVCRA--ASGPGPEQEASFTVTVPPSEG--SSYRLRSPVISIDPP 3029 Query: 1366 QCTVDSEPPAEL-ALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV-PAGDDTY 1423 TV A L HDG + +V ++ N + + P+ TY Sbjct: 3030 SSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTY 3089 Query: 1424 VCTAQNLLGSISTIGRLQVEG---ARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFA 1480 C A N G ++ L V G V+ E + V G A+ L C G P S+ Sbjct: 3090 RCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEP----RSSAR 3145 Query: 1481 WFWNDRRLHAEPV-------------PTLAFTHVARAQAGMYHCLAELPTGAAASAPVML 1527 W R+ + P L + + AG Y CLA+ G A Sbjct: 3146 W----TRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQK----- 3196 Query: 1528 RVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHI 1587 + V V+ G + + A LT+ G G+PA P I Sbjct: 3197 ---------QVEVIVDTGAMAPGAPQVQAEE---AELTVEAGHTATLRCSATGSPA-PTI 3243 Query: 1588 H--VLASP----NALRVD---IEALRPSDQGEYICSASNVLGSASTSTYFGVRA 1632 H L SP + L D I + D G+YIC+A++ G A + V + Sbjct: 3244 HWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVES 3297 Score = 184 bits (466), Expect = 8e-46 Identities = 374/1696 (22%), Positives = 593/1696 (34%), Gaps = 304/1696 (17%) Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEE----PRVPTIASPVEL----- 150 L L + P DSG Y R E + + + +++ T VP P+ + Sbjct: 2102 LRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSS 2161 Query: 151 --LEGTEVDFNCSTPYVCLQEQVRLQWQ---GQDPARSVTFNSQKFEPTGVGHLETLHMA 205 EG +D NC P Q ++ W G PAR T G L LH Sbjct: 2162 HVAEGQTLDLNCVVPG---QAHAQVTWHKRGGSLPARHQTH----------GSLLRLHQV 2208 Query: 206 MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVK-ILLSPSGRNILPGELVTLTCQV 264 + + A + ++ P + + + S + G+ + L+C V Sbjct: 2209 TPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVV 2268 Query: 265 NSSYPAVSSIKWLKDG----VRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPIS 320 A + + W K G R Q + L++ QA+ +DAG Y C+A NG+ + ++ ++ Sbjct: 2269 AGQ--AHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVT 2326 Query: 321 ----LHIFMAEVQVSP------AGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLL--- 367 ++ P + + E QT+ L C P + S + +W+K L Sbjct: 2327 GTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQ--SHAQVTWHKRGGSLPVR 2384 Query: 368 EDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL--TPVL----TAFL 421 H LRL+ A+ AD+G Y C V GS SV+V P P L T + Sbjct: 2385 HQTHGSLLRLYQASPADSGEYVCRVL---GSSVPLEASVLVTIEPAGSVPALGVTPTVRI 2441 Query: 422 ETQAGLVGI-----LHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRL 476 E+ + V L+C V + A + G L + H S RL Sbjct: 2442 ESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPAR-----HQVHGS--------RL 2488 Query: 477 EIRDLEETDSGEYKCSATNSLGNATSTL---------DFHANAARLLI---SPAAEVVEG 524 + + DSGEY C S G +++ H+ + S +A + G Sbjct: 2489 RLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANG 2548 Query: 525 QAVTLSCRSGLSPTPDARFSWYLNGALL---HEGPGSSLLLPAASSTDAGSYHCRARDGH 581 + L+C S P +WY G L H+ GS L +P + D+G Y C +G Sbjct: 2549 HTLDLNCLVA-SQAPHT-ITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGA 2606 Query: 582 SASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGA--GRRGLLLCRVDSDPPARLQLLHK 639 + S + P+ + + ++++ G+ L C V P A + + Sbjct: 2607 GSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKR 2666 Query: 640 DRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNAS 699 GG P T +L +H + + G Y+C A+N + Sbjct: 2667 -----------------GGSLPSRHQTHGSHL---RLHQMSVADSGEYVCRANNNIDALE 2706 Query: 700 TSATFN-----------GQATVLAIAPSHT-LQEGTEANLTCNVSREAAGSPANFSWFRN 747 S + G + + I S + + EG +L C V +A A +W + Sbjct: 2707 ASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAH---AQVTWHKR 2763 Query: 748 GVLWA---QGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSAL 804 G Q + L V+ D+ Y CR++ +G P+ SVL + SA+ Sbjct: 2764 GGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSG-----PLEASVLVTIEASGSSAV 2818 Query: 805 LDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSH---GRFQAKAEANSLKL 861 G S +A + ++ QV H G A+ + + L Sbjct: 2819 HVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLL 2878 Query: 862 EVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQ-------------E 908 + ++ DSG Y C+ T G+ S+ + + P+P L E Sbjct: 2879 RLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTE 2938 Query: 909 GQAVVLSC----QVHTGVPEGTSYRWYRDGQPL---QESTSATLRFAAITLTQAGAYHCQ 961 GQ + L+C Q H V WY+ G L ++ + LR ++ +G Y C+ Sbjct: 2939 GQTLDLNCVVPGQAHAQVT------WYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCR 2992 Query: 962 AQA-PG---SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRL 1017 A + PG A+ ++ P S SY R ++ + V A + Sbjct: 2993 AASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSST---------VQQGQDASFKC 3043 Query: 1018 LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQAS 1077 L D +L+ + +H++ PN + I G + G Y C ASN G A Sbjct: 3044 LIHDGAAPISLEWKTRNQELEDNVHIS--PNGSIITIVGTRPSNHGTYRCVASNAYGVAQ 3101 Query: 1078 ASADFDAQAV-NVQVWPGATV--REGQLVNLTCLV---------WT---THPAQLTYTWY 1122 + + V V P V + G+ V L C+ WT + PA+L Y Sbjct: 3102 SVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTY 3161 Query: 1123 QDGQQRLDAHSI-PLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYL 1180 +D+H++ + + DA +Y C G A + I AP ++ Sbjct: 3162 G----LMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV--- 3214 Query: 1181 LESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQP------- 1233 Q TV++ H L S+T + P +LR P P Sbjct: 3215 ------QAEEAELTVEA--------GHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEG 3260 Query: 1234 ----------RDEGFYSCSARSPLGQANTSLELRLEG--VRVILAPEAAVPEGAPITVTC 1281 +D G Y C+A SP G A ++ L +E + A+V G + + C Sbjct: 3261 DTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQC 3320 Query: 1282 ADPAAHA--PTLYTWYHNGRWLQEGPAASLSFLVATRA---HAGAYSCQAQD-------- 1328 AH P + W G L A L RA +G Y C+ + Sbjct: 3321 L---AHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAF 3377 Query: 1329 ----AQGTRSSRPA-ALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDG 1383 QG S PA ++ P V + C V S+ +L +G Sbjct: 3378 AQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEG 3437 Query: 1384 KVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVE 1443 L HS+ G LR+Q D TY+C A G +L ++ Sbjct: 3438 GQLPPG---HSVQDGV---------LRIQNLDQSC-QGTYICQAHGPWGKAQASAQLVIQ 3484 Query: 1444 GARVVA----EPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPV-----P 1494 V V G A+ C LG P P W+ H P Sbjct: 3485 ALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVT------WSKVGGHLRPGIVQSGG 3538 Query: 1495 TLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDC 1554 + HV A AG Y C A G S ++L P + V V G + C Sbjct: 3539 VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVP--AGSAAVFPC 3596 Query: 1555 RVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICS 1614 P ++ S+L S P E ++ +L S +RP D G Y+C+ Sbjct: 3597 IASGYPTPDISW---SKLDGSLPPDSR-LENNMLMLPS----------VRPQDAGTYVCT 3642 Query: 1615 ASNVLGSASTSTYFGV 1630 A+N G + V Sbjct: 3643 ATNRQGKVKAFAHLQV 3658 Score = 181 bits (459), Expect = 5e-45 Identities = 377/1594 (23%), Positives = 584/1594 (36%), Gaps = 327/1594 (20%) Query: 226 AQSEIHLQVKYA----PKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGV 281 AQ+ I + V A P VKI S ++ G+ + L C V S A + + W + G Sbjct: 2034 AQARIQVVVLSASDASPPPVKI--ESSSPSVTEGQTLDLNCVVAGS--AHAQVTWYRRGG 2089 Query: 282 RLQTKTGV----LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGP-- 335 L T V L LPQ + +D+G Y C+ ENG G P I ++ + + +GP Sbjct: 2090 SLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSG-----PKEASITVSVLHGTHSGPSY 2144 Query: 336 ------------------ILENQTVTLVCNTPNEAPSDLRYSWYKNHVLL---EDAHSHT 374 + E QT+ L C P +A + + +W+K L H Sbjct: 2145 TPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQV--TWHKRGGSLPARHQTHGSL 2202 Query: 375 LRLHLATRADTGFYFCEVQNVHGS-ERSGPVSVVVNHPPLTPVLTAFLETQAGLVG---- 429 LRLH T AD+G Y C V G E S V++ + P P+ +E+ + V Sbjct: 2203 LRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIP-GPIPPVRIESSSSTVAEGQT 2261 Query: 430 -ILHCSVVSEPLATLV-LSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487 L C V + A + GG + A H R S RL I D+G Sbjct: 2262 LDLSCVVAGQAHAQVTWYKRGGSLPAR------HQVRGS--------RLYIFQASPADAG 2307 Query: 488 EYKCSATNSL---------GNATSTLDFHANAAR-LLISP-AAEVVEGQAVTLSCRSGLS 536 +Y C A+N + G + L + A + + + I P +++V EGQ + L+C + Sbjct: 2308 QYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNC--VVP 2365 Query: 537 PTPDARFSWYLNGALL---HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLT 593 A+ +W+ G L H+ GS L L AS D+G Y CR +S P +VL Sbjct: 2366 GQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVL---GSSVPLEASVLV 2422 Query: 594 VLYPPRQ-----PTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLP 648 + P T T R++ ++ G+ L C V A++ HK Sbjct: 2423 TIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQV-TWHKR-------- 2473 Query: 649 SGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQA 708 GG P L +++ + G Y+C + G S Q Sbjct: 2474 --------GGSLPARHQVHGSRLRLLQV---TPADSGEYVCRVVGSSGTQEASVLVTIQQ 2522 Query: 709 ------------TVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWF-RNGVLWAQGP 755 V + S +L G +L C V+ +A P +W+ R G L ++ Sbjct: 2523 RLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQA---PHTITWYKRGGSLPSRHQ 2579 Query: 756 L--ETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSV----------LYPPDRPKLSA 803 + + + V D+ Y C + AG++ T +++++ + PP R + S+ Sbjct: 2580 IVGSRLRIPQVTPADSGEYVCHVSNGAGSR-ETSLIVTIQGSGSSHVPSVSPPIRIE-SS 2637 Query: 804 LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863 + +G C V +P A++ + G +PS + + + L + Sbjct: 2638 SPTVVEGQTLDLNCVVARQPQAIITWY--------KRGGSLPS------RHQTHGSHLRL 2683 Query: 864 RELGLGDSGSYRCEATNVLGSSNTSLFFQVR---------GAWVQV---SPSPELQEGQA 911 ++ + DSG Y C A N + + S+ V G+ + + S S + EG+ Sbjct: 2684 HQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGET 2743 Query: 912 VVLSC----QVHTGVPEGTSYRWYRDGQPL---QESTSATLRFAAITLTQAGAYHCQAQ- 963 + L+C Q H V W++ G L ++ + LR ++ +G Y C+ Sbjct: 2744 LDLNCVVPGQAHAQV------TWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMG 2797 Query: 964 APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRL 1023 + G S+ I S A HV P G R++ P+ R+ G L Sbjct: 2798 SSGPLEASVLVTIEASGSSAV-HV---------PAPGGAPPIRIE---PSSSRVAEGQTL 2844 Query: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLE-------DEGVYICEASNTLGQA 1076 + V G + H R ++HG +L D G Y C+ + + G Sbjct: 2845 DLKCV--VPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTL 2902 Query: 1077 SAS--------------ADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWY 1122 AS A AQ + ++ + V EGQ ++L C+V AQ+ TWY Sbjct: 2903 EASVLVTIEPSSPGPIPAPGLAQPIYIEA-SSSHVTEGQTLDLNCVVPGQAHAQV--TWY 2959 Query: 1123 QDG-----QQRLDAHSIPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLR 1176 + G + + + L V+ D+ Y C PG S +T+ P + Sbjct: 2960 KRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTV-----PPSEG 3014 Query: 1177 LTYLLES------------HGGQLALVLCTV-DSRPPAQLALSHAGRLLASSTAASVPNT 1223 +Y L S GQ A C + D P L + L + S PN Sbjct: 3015 SSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHIS-PNG 3073 Query: 1224 LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG---VRVILAPEAAVPEGAPITVT 1280 + + G +P + G Y C A + G A + + L + G V V+ V G +T+ Sbjct: 3074 SIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLE 3133 Query: 1281 CADPAAHAPTLYTWYHNGRW--LQEGPA-------------ASLSFLVATRAHAGAYSCQ 1325 C +A P + RW + PA A L A + AG Y C Sbjct: 3134 CV--SAGEPR-----SSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCL 3186 Query: 1326 AQDAQGTRSSRPAAL-----QVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALS 1380 AQ+A GT + + APQ + A A ++C+ P + Sbjct: 3187 AQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTI--- 3243 Query: 1381 HDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRL 1440 H K+ + H L T + R+ QD Y+C A + G L Sbjct: 3244 HWSKLRSPLPWQHRLEGDTLIIP------RVAQQD----SGQYICNATSPAGHAEATIIL 3293 Query: 1441 QVEG---ARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLA 1497 VE A V E V G + L C G P P+ TF W L Sbjct: 3294 HVESPPYATTVPEHA-SVQAGETVQLQCLAHGTP-PL---TFQWSRVGSSLPGRATARNE 3348 Query: 1498 FTHVARA---QAGMYHCLAELPTGAAASAPVMLRVLYPP-----------KTPTMMVFVE 1543 H RA +G Y C G +A A L V PP TPT+ V + Sbjct: 3349 LLHFERAAPEDSGRYRCRVTNKVG-SAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQ 3407 Query: 1544 PEG---GLRGILDCRVDSEPLASLT-LHLGSRLVASSQPQGAPAEPHIHVLASPNALRVD 1599 E G C V S+ L G +L P G + + + Sbjct: 3408 LETKSIGASVEFHCAVPSDRGTQLRWFKEGGQL-----PPGHSVQDGV----------LR 3452 Query: 1600 IEALRPSDQGEYICSASNVLGSASTSTYFGVRAL 1633 I+ L S QG YIC A G A S ++AL Sbjct: 3453 IQNLDQSCQGTYICQAHGPWGKAQASAQLVIQAL 3486 Score = 156 bits (394), Expect = 2e-37 Identities = 347/1569 (22%), Positives = 559/1569 (35%), Gaps = 307/1569 (19%) Query: 243 ILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDG----VRLQTKTGVLHLPQAAWS 298 I + PS ++ G+ + L C V A + + W K G R QT +L L Q + Sbjct: 2154 IRIEPSSSHVAEGQTLDLNCVVPGQ--AHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPA 2211 Query: 299 DAGVYTCQAENGVGSL-VSPPISLHIFMAEVQVSP------AGPILENQTVTLVCNTPNE 351 D+G Y C G L S +++ + + P + + E QT+ L C + Sbjct: 2212 DSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQ 2271 Query: 352 APSDLRYSWYKNHVLLEDAHS---HTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVV 408 A + + +WYK L H L + A+ AD G Y C N G E S V+V Sbjct: 2272 AHAQV--TWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASN--GMEASITVTV-- 2325 Query: 409 NHPPLTPVLTAFLETQAGLVGILHCSVVSEPLA-------TLVLSHGGHILASTSGDSDH 461 T A L AG + S +A V+ H + Sbjct: 2326 -----TGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGS 2380 Query: 462 SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSL----GNATSTLDFHANAARLLISP 517 P T G L + DSGEY C S + T++ + L ++P Sbjct: 2381 LPVRHQTHGS---LLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTP 2437 Query: 518 -------AAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALL---HEGPGSSLLLPAASS 567 +++V EGQ + L+C ++ A+ +W+ G L H+ GS L L + Sbjct: 2438 TVRIESSSSQVAEGQTLDLNCL--VAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTP 2495 Query: 568 TDAGSYHCRARDGHSASGPSSPAVLTVLYP------PRQPTFTTRLDLDAAGAGAGRRGL 621 D+G Y CR +SG +VL + + + R++ +A G Sbjct: 2496 ADSGEYVCRVV---GSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLD 2552 Query: 622 LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLL 681 L C V S P + + SLPS R ++ + R+ I Sbjct: 2553 LNCLVASQAPHTITWYKR----GGSLPS------------RHQIVGS----RLRIPQVTP 2592 Query: 682 EEEGLYLCEASNALGNASTSATF----NGQATVLAIAP-------SHTLQEGTEANLTCN 730 + G Y+C SN G+ TS +G + V +++P S T+ EG +L C Sbjct: 2593 ADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCV 2652 Query: 731 VSREAAGSPANFSWFRNGVLWAQGPLET--------VTLLPVARTDAALYACRILTEAGA 782 V+R+ A +W++ G G L + + L ++ D+ Y CR A Sbjct: 2653 VARQPQ---AIITWYKRG-----GSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDA 2704 Query: 783 QLSTPVLLSVLYPPDRPK-----LSALLDMGQGHMALFICTVDSRPLALLALFHGE-HLL 836 L +++SV P + ++ H+A + L L + G+ H Sbjct: 2705 -LEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVA------EGETLDLNCVVPGQAHAQ 2757 Query: 837 AT--SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894 T G +PSH + + +L + + DSG Y C G S+ + Sbjct: 2758 VTWHKRGGSLPSHHQTRGS------RLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIE 2811 Query: 895 GAW--------------VQVSPSPE-LQEGQAVVLSC----QVHTGVPEGTSYRWYRDGQ 935 + +++ PS + EGQ + L C Q H V W++ G Sbjct: 2812 ASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVT------WHKRGG 2865 Query: 936 PL---QESTSATLRFAAITLTQAGAYHCQA-----------------QAPGSATT-SLAA 974 L + LR ++ +G Y CQ +PG LA Sbjct: 2866 NLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQ 2925 Query: 975 PISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034 PI + S + HVT +D L C V AQ+ + + Q Sbjct: 2926 PIYIEASSS--HVTEGQTLD--------LNCVVPGQAHAQVTWYKRGGSLPARHQ----T 2971 Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQA-----------SASADFD 1083 GS RLH+ V+P D G Y+C A++ G S + + Sbjct: 2972 HGSQLRLHL-VSP------------ADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYR 3018 Query: 1084 AQAVNVQVWP-GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLD-AHSIPLPNVTV 1141 ++ + + P +TV++GQ + CL+ A ++ W Q+ D H P ++ Sbjct: 3019 LRSPVISIDPPSSTVQQGQDASFKCLIHDG-AAPISLEWKTRNQELEDNVHISPNGSIIT 3077 Query: 1142 RDAT------SYRC------GVGPPGRAPRLSRPITLDVL-----YAPRNLRLTYLLESH 1184 T +YRC GV + P T+ VL + +T S Sbjct: 3078 IVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSA 3137 Query: 1185 GGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSAR 1244 G + T S PA+L G L S A L++ +P D G Y C A+ Sbjct: 3138 GEPRSSARWTRISSTPAKLEQRTYG--LMDSHAV-------LQISSAKPSDAGTYVCLAQ 3188 Query: 1245 SPLGQANTSLELRLE------GVRVILAPEA--AVPEGAPITVTCADPAAHAPTLYTWYH 1296 + LG A +E+ ++ G + A EA V G T+ C+ + APT++ W Sbjct: 3189 NALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIH-WSK 3247 Query: 1297 NGR---WLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSS 1353 W +L + +G Y C A G + L V P + Sbjct: 3248 LRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAG-HAEATIILHVESPPYATTVPE 3306 Query: 1354 FRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQV 1413 +A +QC PP S G L + ARN L Sbjct: 3307 HASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRA-------------TARNELLHFE 3353 Query: 1414 QDVPAGDDTYVCTAQNLLGSISTIGRLQVEGA---------------RVVAEPGLDVPE- 1457 + P Y C N +GS +L V+G V P L+ Sbjct: 3354 RAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSI 3413 Query: 1458 GAALNLSCRLLGGPGPVGNSTFAWFWNDRRL---HAEPVPTLAFTHVARAQAGMYHCLAE 1514 GA++ C + G + WF +L H+ L ++ ++ G Y C A Sbjct: 3414 GASVEFHCAVPSDRG----TQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAH 3469 Query: 1515 LPTGAA-ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLV 1573 P G A ASA ++++ L P++++ +R + V + L LG Sbjct: 3470 GPWGKAQASAQLVIQAL-----PSVLI------NIRTSVQTVVVGHAVEFECLALGD--- 3515 Query: 1574 ASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRAL 1633 Q + H+ + V I + +D G+Y C+A+N G+ + V+AL Sbjct: 3516 PKPQVTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQAL 3575 Query: 1634 HRLHQFQQL 1642 ++ Q++ Sbjct: 3576 PQISMPQEV 3584 Score = 117 bits (292), Expect = 1e-25 Identities = 221/958 (23%), Positives = 352/958 (36%), Gaps = 170/958 (17%) Query: 93 PEH---RVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTL-------VTVTEEPRVP 142 P H R L L + P DSG Y R S + V T+ V V P Sbjct: 2768 PSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAP 2827 Query: 143 TIA---SPVELLEGTEVDFNCSTPYVCLQEQVRLQWQ---GQDPARSVTFNSQKFEPTGV 196 I S + EG +D C P Q ++ W G PAR Sbjct: 2828 PIRIEPSSSRVAEGQTLDLKCVVPG---QAHAQVTWHKRGGNLPARHQVH---------- 2874 Query: 197 GHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGV--------KILLSPS 248 G L L+ +S D G CQ++ ++ ++ + + ++ + G I + S Sbjct: 2875 GPLLRLNQ-VSPADSGEY-SCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEAS 2932 Query: 249 GRNILPGELVTLTCQVNSSYPAVSSIKWLKDG----VRLQTKTGVLHLPQAAWSDAGVYT 304 ++ G+ + L C V A + + W K G R QT L L + +D+G Y Sbjct: 2933 SSHVTEGQTLDLNCVVPGQ--AHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYV 2990 Query: 305 CQAENGVG-------SLVSPPISLHIFMAEVQV----SPAGPILENQTVTLVCNTPNEAP 353 C+A +G G ++ PP + V P+ + + Q + C ++ Sbjct: 2991 CRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLI-HDGA 3049 Query: 354 SDLRYSWYKNHVLLED----AHSHTLRLHLATR-ADTGFYFCEVQNVHGSERSGPVSVVV 408 + + W + LED + + ++ + TR ++ G Y C N +G +S V++ V Sbjct: 3050 APISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQS-VVNLSV 3108 Query: 409 NHPPLTPVLTAF-LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSG 467 + PP VL + + G L C EP ++ + ++ST + R G Sbjct: 3109 HGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTR----ISSTPAKLEQ--RTYG 3162 Query: 468 TSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE---- 523 +++ L+I + +D+G Y C A N+LG A ++ + + +P A V+ Sbjct: 3163 LMDSHAV-LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAM--APGAPQVQAEEA 3219 Query: 524 ------GQAVTLSCRSGLSPTPDARFSWYLNGAL--LHEGPGSSLLLPAASSTDAGSYHC 575 G TL C + SP P +S L L H G +L++P + D+G Y C Sbjct: 3220 ELTVEAGHTATLRCSATGSPAPTIHWS-KLRSPLPWQHRLEGDTLIIPRVAQQDSGQYIC 3278 Query: 576 RARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635 +A+ P+ A T++ P + T + + A AG L C PP Q Sbjct: 3279 ------NATSPAGHAEATIILHVESPPYATTVP-EHASVQAGETVQLQCLAHGTPPLTFQ 3331 Query: 636 LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695 V +SLP + T LL E P E+ G Y C +N + Sbjct: 3332 WSR----VGSSLPG--------------RATARNELLHFERAAP--EDSGRYRCRVTNKV 3371 Query: 696 GNA----------------STSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSP 739 G+A +TS TV T G C V + Sbjct: 3372 GSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRG--- 3428 Query: 740 ANFSWFRNGVLWAQGPLETVTLLPVARTDAAL---YACRI-----LTEAGAQLSTPVLLS 791 WF+ G G +L + D + Y C+ +A AQL L S Sbjct: 3429 TQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPS 3488 Query: 792 VLYPPDRPKLSALLDMGQGHMALFICTV--DSRPLALLALFHGEHLLATSLGPQVPSHGR 849 VL + ++ GH F C D +P + G L P + G Sbjct: 3489 VLINIRTSVQTVVV----GHAVEFECLALGDPKPQVTWSKVGGH------LRPGIVQSGG 3538 Query: 850 FQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQ-- 907 + + + L D+G YRC ATN G++ + + V+ A Q+S E++ Sbjct: 3539 V----------VRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQ-ALPQISMPQEVRVP 3587 Query: 908 EGQAVVLSCQVHTGVPEGTSYRWYR-DGQ--PLQESTSATLRFAAITLTQAGAYHCQA 962 G A V C + +G P W + DG P + L ++ AG Y C A Sbjct: 3588 AGSAAVFPC-IASGYPT-PDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTA 3643 Score = 33.5 bits (75), Expect = 1.8 Identities = 15/40 (37%), Positives = 21/40 (52%) Query: 844 VPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLG 883 +PSH R +E L +R++ D G+Y CEA N G Sbjct: 447 IPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486 Score = 32.3 bits (72), Expect = 4.1 Identities = 16/36 (44%), Positives = 21/36 (58%) Query: 463 PRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG 498 PR + TS L IRD++E+D G Y C A N+ G Sbjct: 451 PRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486 >gi|157168355 CD22 molecule [Homo sapiens] Length = 847 Score = 178 bits (452), Expect = 4e-44 Identities = 174/659 (26%), Positives = 286/659 (43%), Gaps = 73/659 (11%) Query: 5 PKLLLLASFFPA--GQASWGVSSPQDVQGVKGSCLLIPCIF-SFPADVEVPDGITAIWYY 61 P LLLL + A + W P+ + +G+C+ IPC + + D+E + I ++ Sbjct: 6 PWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLE-----SFILFH 60 Query: 62 DYSGQRQVVSHSADPKLVEARFRG-------RTEFMGNPEHRVCNLLLKDLQPEDSGSYN 114 + + S +L E+ G R +F+G+ +++ C L + + DSG Sbjct: 61 NPEYNKNT-SKFDGTRLYESTKDGKVPSEQKRVQFLGD-KNKNCTLSIHPVHLNDSGQLG 118 Query: 115 FRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQ 174 R E S+ +W ++ + V+E P P I P E+ E EV C + C ++LQ Sbjct: 119 LRME-SKTEKW--MERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQ 175 Query: 175 WQGQD-PARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHR--AQSEIH 231 W + P R S V L + W HG+I+ CQL A+ + + + Sbjct: 176 WLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQ 235 Query: 232 LQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTK-TGVL 290 L VK+ PK ++I ++PS + G+ VT+TC+V+SS P +++ WLKDG L+ + T L Sbjct: 236 LNVKHTPK-LEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTL 294 Query: 291 HLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPA--------GPILENQTV 342 +L + +G Y CQ N VG P S +F+ +VQ +P P +E V Sbjct: 295 NLREVTKDQSGKYCCQVSNDVG----PGRSEEVFL-QVQYAPEPSTVQILHSPAVEGSQV 349 Query: 343 TLVC-NTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERS 401 +C + N P++ Y+WY N ++ + + G Y C +N+ G+ + Sbjct: 350 EFLCMSLANPLPTN--YTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQR 407 Query: 402 GP-VSVVVNHPP--LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGD 458 GP + V +PP +T V+ + + G L C+ S + H Sbjct: 408 GPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPH-------- 459 Query: 459 SDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR-----L 513 P+ L+I+++ D+ C+A NS + S + + A Sbjct: 460 -------GAWEEPSLGVLKIQNV-GWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVR 511 Query: 514 LISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSY 573 I P +E+ G +V+L C S + +F W NG LL G S L + S DAGSY Sbjct: 512 KIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLL--GKESQLNFDSISPEDAGSY 569 Query: 574 HCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAG-AGAGRRGLLLCRVDSDPP 631 C + + S L VLY PR+ R+ + G+ L C D++PP Sbjct: 570 SCWVNNSIGQTA-SKAWTLEVLYAPRR----LRVSMSPGDQVMEGKSATLTCESDANPP 623 Score = 102 bits (254), Expect = 3e-21 Identities = 128/516 (24%), Positives = 204/516 (39%), Gaps = 90/516 (17%) Query: 711 LAIAPSHTL-QEGTEANLTCNVSREAAGSP--ANFSWFRNGVLWAQGPLETVTLLPVART 767 + + PS + +EG +TC VS + +P SW ++G + T+ L V + Sbjct: 246 IKVTPSDAIVREGDSVTMTCEVS---SSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKD 302 Query: 768 DAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMG-QGHMALFICTVDSRPLAL 826 + Y C++ + G S V L V Y P+ + L +G F+C + PL Sbjct: 303 QSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPT 362 Query: 827 LALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN 886 ++ + Q + E K+ + ++ +G+Y C A N+LG+ Sbjct: 363 NYTWY-------------HNGKEMQGRTEE---KVHIPKILPWHAGTYSCVAENILGTGQ 406 Query: 887 TSLFFQVRGAWVQVSPSPE-----------LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQ 935 GA + V P+ ++EG V LSC ++ P T Y W G Sbjct: 407 RG-----PGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHG- 460 Query: 936 PLQESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHV---TLTTL 992 +E + L+ + A A ++ S A+P++L+V YAPR V + L Sbjct: 461 AWEEPSLGVLKIQNVGWDNTTI----ACAACNSWCSWASPVALNVQYAPRDVRVRKIKPL 516 Query: 993 MDTGPGRLGLLLCRVDSDPPAQLRLL--HGDRLVASTLQGVGGPEGSSPRLHVAVAPNTL 1050 + G L C S P +++ RL+ Q Sbjct: 517 SEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ--------------------- 555 Query: 1051 RLEIHGAMLEDEGVYICEASNTLGQASASA-----DFDAQAVNVQVWPGATVREGQLVNL 1105 L ED G Y C +N++GQ ++ A + + + V + PG V EG+ L Sbjct: 556 -LNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATL 614 Query: 1106 TCLVWTTHPAQLTYTWYQDGQQRLDAHS--IPLPNVTVRDATSYRC----GVGPPGRAPR 1159 TC +P YTW+ Q L HS + L V V+ + +Y C VG GR+P Sbjct: 615 TC-ESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVG-KGRSP- 671 Query: 1160 LSRPITLDVLYAPRNL--RLTYLLESHGGQLALVLC 1193 LS TL V Y+P + R+ L S L L +C Sbjct: 672 LS---TLTVYYSPETIGRRVAVGLGSCLAILILAIC 704 Score = 95.9 bits (237), Expect = 3e-19 Identities = 123/480 (25%), Positives = 198/480 (41%), Gaps = 71/480 (14%) Query: 1087 VNVQVWPG-ATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQ--QRLDAHSIPLPNVTVRD 1143 + ++V P A VREG V +TC V +++P T +W +DG ++ + ++ L VT Sbjct: 244 LEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQ 303 Query: 1144 ATSYRCGVG---PPGRAPRLSRPITLDVLYAPR--NLRLTYLLESHGGQLALVLCTVDSR 1198 + Y C V PGR S + L V YAP +++ + G Q+ + ++ + Sbjct: 304 SGKYCCQVSNDVGPGR----SEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANP 359 Query: 1199 PPAQLALSHAGRLLASSTAASV--PNTLRLELRGPQPRDEGFYSCSARSPL--GQANTSL 1254 P H G+ + T V P L P G YSC A + L GQ Sbjct: 360 LPTNYTWYHNGKEMQGRTEEKVHIPKIL--------PWHAGTYSCVAENILGTGQRGPGA 411 Query: 1255 ELRLE----GVRVILAPEAAVPEGAPITVTCADPAAH-APTLYTWYHNGRWLQEGPAASL 1309 EL ++ V ++ + EG +T++C +++ + T Y W +G W E P+ + Sbjct: 412 ELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAW--EEPSLGV 469 Query: 1310 SFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR---DSRARSMAVIQ 1366 + +C A ++ + +S P AL V YAP+D + + + + + +Q Sbjct: 470 LKIQNVGWDNTTIACAACNSWCSWAS-PVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQ 528 Query: 1367 CTVDSEPPAELAL--SHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV-PAGDDTY 1423 C S P E+ +G++L S +L + P +Y Sbjct: 529 CDFSSSHPKEVQFFWEKNGRLLGKES-------------------QLNFDSISPEDAGSY 569 Query: 1424 VCTAQNLLG-SISTIGRLQVEGA----RVVAEPGLDVPEGAALNLSCRLLGGPGPVGNST 1478 C N +G + S L+V A RV PG V EG + L+C P PV S Sbjct: 570 SCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANP-PV--SH 626 Query: 1479 FAWF-WNDRRL--HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKT 1535 + WF WN++ L H++ L V +G Y C G S L V Y P+T Sbjct: 627 YTWFDWNNQSLPYHSQ---KLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPET 683 Score = 93.2 bits (230), Expect = 2e-18 Identities = 114/420 (27%), Positives = 180/420 (42%), Gaps = 53/420 (12%) Query: 201 TLHMAMSWQDHGRILRCQLS--VANHRAQSEIHLQVKYAPKG--VKILLSPSGRNILPGE 256 TL++ +D CQ+S V R++ E+ LQV+YAP+ V+IL SP+ + G Sbjct: 293 TLNLREVTKDQSGKYCCQVSNDVGPGRSE-EVFLQVQYAPEPSTVQILHSPA----VEGS 347 Query: 257 LVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV-LHLPQAAWSDAGVYTCQAENGVGS-L 314 V C ++ + P ++ W +G +Q +T +H+P+ AG Y+C AEN +G+ Sbjct: 348 QVEFLC-MSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQ 406 Query: 315 VSPPISLHIFMAEVQVSPA----GPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDA 370 P L + +V+ PI E TVTL CN + PS RY W K H E+ Sbjct: 407 RGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEW-KPHGAWEEP 465 Query: 371 HSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL---TPVLTAFLETQAGL 427 L++ +T C N S S PV++ V + P + E +G Sbjct: 466 SLGVLKIQNVGWDNTTIA-CAACNSWCSWAS-PVALNVQYAPRDVRVRKIKPLSEIHSGN 523 Query: 428 VGILHCSVVSEPLATLVL--SHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETD 485 L C S + G +L S +L + D Sbjct: 524 SVSLQCDFSSSHPKEVQFFWEKNGRLLGKES------------------QLNFDSISPED 565 Query: 486 SGEYKCSATNSLGNATS---TLD--FHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPD 540 +G Y C NS+G S TL+ + R+ +SP +V+EG++ TL+C S +P P Sbjct: 566 AGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANP-PV 624 Query: 541 ARFSWY--LNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598 + ++W+ N +L + L L +G+Y C+ + G S + LTV Y P Sbjct: 625 SHYTWFDWNNQSLPYH--SQKLRLEPVKVQHSGAYWCQGTNS-VGKGRSPLSTLTVYYSP 681 Score = 84.3 bits (207), Expect = 9e-16 Identities = 136/593 (22%), Positives = 234/593 (39%), Gaps = 88/593 (14%) Query: 830 FHGEHLLATSLGPQVPSHG-RFQAKAEAN-SLKLEVRELGLGDSGSY--RCEATNVLGSS 885 F G L ++ +VPS R Q + N + L + + L DSG R E+ Sbjct: 71 FDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWME 130 Query: 886 NTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVH---TGVPEGTSYRWYRDGQPLQE--- 939 L R + PE+QE Q V L+C ++ G P +W +G P+++ Sbjct: 131 RIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYP--IQLQWLLEGVPMRQAAV 188 Query: 940 -STSATLRF----AAITLTQAGAYH-----CQAQ-APGSATTSLAAPISLHVSYAPRHVT 988 STS T++ + + + ++H CQ Q A G ++ + L+V + P+ Sbjct: 189 TSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSN--DTVQLNVKHTPKLEI 246 Query: 989 LTTLMD--TGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVA 1046 T D G + C V S P + S L+ +G+S + Sbjct: 247 KVTPSDAIVREGDSVTMTCEVSSSNP--------EYTTVSWLK-----DGTSLK-----K 288 Query: 1047 PNTLRLEIHGAMLEDEGVYICEASNTLG-----QASASADFDAQAVNVQVWPGATVREGQ 1101 NT L + + G Y C+ SN +G + + + VQ+ V EG Sbjct: 289 QNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAV-EGS 347 Query: 1102 LVNLTCLVWTTHPAQLTYTWYQDGQ--QRLDAHSIPLPNVTVRDATSYRC------GVGP 1153 V C+ +P YTWY +G+ Q + +P + A +Y C G G Sbjct: 348 QVEFLCMS-LANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQ 406 Query: 1154 PGRAPRLSRPITLDVLYAPRNLRLTYLLES----HGGQLALVLCTVDSRPPAQLALSHAG 1209 G LDV Y P+ ++T ++++ G + C +S P+ Sbjct: 407 RGPGAE------LDVQYPPK--KVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKP 458 Query: 1210 RLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE----GVRV-I 1264 + V L+++ G D +C+A + + + L ++ VRV Sbjct: 459 HGAWEEPSLGV---LKIQNVG---WDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRK 512 Query: 1265 LAPEAAVPEGAPITVTCADPAAHAPTL-YTWYHNGRWLQEGPAASLSFLVATRAHAGAYS 1323 + P + + G +++ C ++H + + W NGR L G + L+F + AG+YS Sbjct: 513 IKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLL--GKESQLNFDSISPEDAGSYS 570 Query: 1324 CQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPP 1374 C ++ G +S+ L+VLYAP+ +S + A + C D+ PP Sbjct: 571 CWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPP 623 Score = 84.0 bits (206), Expect = 1e-15 Identities = 57/191 (29%), Positives = 87/191 (45%), Gaps = 6/191 (3%) Query: 228 SEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKT 287 S + L V+YAP+ V++ I G V+L C +SS+P W K+G RL K Sbjct: 495 SPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNG-RLLGKE 553 Query: 288 GVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA----EVQVSPAGPILENQTVT 343 L+ + DAG Y+C N +G S +L + A V +SP ++E ++ T Sbjct: 554 SQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSAT 613 Query: 344 LVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGP 403 L C + P Y+W+ + HS LRL +G Y+C+ N G RS Sbjct: 614 LTCESDANPPVS-HYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPL 672 Query: 404 VSVVVNHPPLT 414 ++ V + P T Sbjct: 673 STLTVYYSPET 683 Score = 68.6 bits (166), Expect = 5e-11 Identities = 115/526 (21%), Positives = 192/526 (36%), Gaps = 85/526 (16%) Query: 520 EVVEGQAVTLSCRSGLSPTP-DARFSWYLNGALLHEGPGSSLLLPAASS--------TDA 570 E+ E Q VTL+C S + W L G + + +S L S + Sbjct: 150 EIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQ 209 Query: 571 GSYH-----CRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCR 625 S+H C+ +D + L V + P+ T D A G + C Sbjct: 210 WSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSD---AIVREGDSVTMTCE 266 Query: 626 VDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685 V S P + + L G K N + + ++ G Sbjct: 267 VSSSNP--------EYTTVSWLKDGTSL-------------KKQNTFTLNLREVTKDQSG 305 Query: 686 LYLCEASNALGNASTSATF-----NGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740 Y C+ SN +G + F + + + I S + EG++ C A P Sbjct: 306 KYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAV-EGSQVEFLC--MSLANPLPT 362 Query: 741 NFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAG-AQLSTPVLLSVLYPPDRP 799 N++W+ NG E V + + A Y+C G Q L V YPP + Sbjct: 363 NYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKK- 421 Query: 800 KLSALLDMGQGHMALFICTVDSRPLALLALFHGEHL-LATSLGPQVPSHGRFQAK----- 853 + TV P+ + G+ + L+ + PS R++ K Sbjct: 422 ----------------VTTVIQNPMPIR---EGDTVTLSCNYNSSNPSVTRYEWKPHGAW 462 Query: 854 AEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGA-----WVQVSPSPELQE 908 E + L+++ +G D+ + C A N S + + V+ A ++ P E+ Sbjct: 463 EEPSLGVLKIQNVG-WDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHS 521 Query: 909 GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSA 968 G +V L C + P+ + W ++G+ L + + L F +I+ AG+Y C Sbjct: 522 GNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ--LNFDSISPEDAGSYSCWVNNSIGQ 579 Query: 969 TTSLAAPISLHVSYAPR--HVTLTTLMDTGPGRLGLLLCRVDSDPP 1012 T S A +L V YAPR V+++ G+ L C D++PP Sbjct: 580 TASKA--WTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPP 623 Score = 57.4 bits (137), Expect = 1e-07 Identities = 82/383 (21%), Positives = 144/383 (37%), Gaps = 72/383 (18%) Query: 1268 EAAVPEGAPITVTCADPAAHAP-TLYTWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQA 1326 +A V EG +T+TC +++ T +W +G L++ +L+ T+ +G Y CQ Sbjct: 252 DAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQV 311 Query: 1327 QDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR-SMAVIQCTVDSEP-PAELALSHDGK 1384 + G S LQV YAP+ + + S C + P P H+GK Sbjct: 312 SNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGK 371 Query: 1385 VL--ATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV 1442 + T VH + +P TY C A+N+LG+ ++ Sbjct: 372 EMQGRTEEKVHI------------------PKILPWHAGTYSCVAENILGTGQRGPGAEL 413 Query: 1443 E------GARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAW----FWNDRRLHAEP 1492 + V + + + EG + LSC V + + W W + L Sbjct: 414 DVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSV--TRYEWKPHGAWEEPSLGVLK 471 Query: 1493 VPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGIL 1552 + + + + A A + + ++PV L V Y P+ Sbjct: 472 IQNVGWDNTTIA-------CAACNSWCSWASPVALNVQYAPR------------------ 506 Query: 1553 DCRVDS-EPLASLTLHLGSRL-----VASSQPQGAPA--EPHIHVLASPNALRVDIEALR 1604 D RV +PL+ +H G+ + +SS P+ E + +L + L D ++ Sbjct: 507 DVRVRKIKPLSE--IHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFD--SIS 562 Query: 1605 PSDQGEYICSASNVLGSASTSTY 1627 P D G Y C +N +G ++ + Sbjct: 563 PEDAGSYSCWVNNSIGQTASKAW 585 >gi|118572606 hemicentin 1 [Homo sapiens] Length = 5635 Score = 170 bits (431), Expect = 1e-41 Identities = 378/1698 (22%), Positives = 598/1698 (35%), Gaps = 312/1698 (18%) Query: 84 RGRTEFMGNPEHRVCN----LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEP 139 +G + + + EH V N L + P D+G Y ++ +D + V E P Sbjct: 1206 KGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTC---VATNIAGTDETEITLHVQEPP 1262 Query: 140 RVPTIASPV-----ELLEGTEVDFNC---STPYVCLQEQVRLQWQGQDPARSVTFNSQKF 191 V + P E + ++F C TP + ++W R +T Sbjct: 1263 TVEDLEPPYNTTFQERVANQRIEFPCPAKGTP------KPTIKWLHN--GRELTGREPGI 1314 Query: 192 EPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRN 251 G L + + D+G + ++ A + + +L+V + P +K + + Sbjct: 1315 SILEDGTLLVIASVTPY-DNGEYICVAVNEAG-TTERKYNLKV-HVPPVIKDKEQVTNVS 1371 Query: 252 ILPGELVTLTCQVNSSYPAVSSIKWLKDGVR------LQTKTG--VLHLPQAAWSDAGVY 303 +L +L L C+V + + I W KD V+ +QT +L L +A DAG Y Sbjct: 1372 VLLNQLTNLFCEVEGTPSPI--IMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRY 1429 Query: 304 TCQAENGVGS---------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPS 354 +C+A N G+ LV P I F EV V + N+ V L C Sbjct: 1430 SCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSV------VLNRDVALECQVKGTPFP 1483 Query: 355 DLRYSWYKNH--VLLEDAHSHTLR----LHL--ATRADTGFYFCEVQNVHGSERSGPVSV 406 D+ W+K+ + L D + L LHL A R D G Y C V N G + + + Sbjct: 1484 DIH--WFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKD-IKL 1540 Query: 407 VVNHPPLTPV--LTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTS-------G 457 + PP +T + + L C P+ + G + S+S G Sbjct: 1541 TIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKG 1600 Query: 458 DSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANA------- 510 H PR + +DS Y C N G A + FH + Sbjct: 1601 QYLHIPR----------------AQVSDSATYTCHVANVAGTAEKS--FHVDVYVPPMIE 1642 Query: 511 ARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH-------EGPGSSLLLP 563 L +VV ++TL C++ +P+P +W +G + E G L + Sbjct: 1643 GNLATPLNKQVVIAHSLTLECKAAGNPSPI--LTWLKDGVPVKANDNIRIEAGGKKLEIM 1700 Query: 564 AASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQP----------TFTTRLDLDAAG 613 +A D G Y C A A + VL PP L+LD Sbjct: 1701 SAQEIDRGQYICVATS--VAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELD--- 1755 Query: 614 AGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLR 673 C V PP + L +++ R N + Sbjct: 1756 ----------CHVTGSPPPTIMWLKDGQLI----------------DERDGFKILLNGRK 1789 Query: 674 VEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSR 733 + I + GLY C A+N G+ + V P G + Sbjct: 1790 LVIAQAQVSNTGLYRCMAANTAGDHKK------EFEVTVHVPPTIKSSGLSERVVVKYKP 1843 Query: 734 EAAGSPAN------FSWFRNG--VLWAQGPLETVT---LLPVART---DAALYACRILTE 779 A AN +W ++ V AQG L+ + +L +A+T DA Y C + T Sbjct: 1844 VALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTC-VATN 1902 Query: 780 AGAQLSTPVLLSVLYPPDRPKLSALLD--MGQGHMALFICTVDSRPLALLALFHGEHLLA 837 A + + L V PP +L+ + + C P+ ++ + LL+ Sbjct: 1903 AAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLS 1962 Query: 838 TSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAW 897 S + G+ +++ + D+G Y+C A N G+ T LF+ ++ Sbjct: 1963 GSTSMTFLNRGQI----------IDIESAQISDAGIYKCVAINSAGA--TELFYSLQ--- 2007 Query: 898 VQVSPSPELQEGQAVV-------LSCQVHTGVPEGTSYRWYRDGQPLQE--------STS 942 V V+PS V L C+ G+P S W +DG P+ S Sbjct: 2008 VHVAPSISGSNNMVAVVVNNPVRLECEAR-GIP-APSLTWLKDGSPVSSFSNGLQVLSGG 2065 Query: 943 ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL 1002 L + ++ G Y C A +A I L V P + + + Sbjct: 2066 RILALTSAQISDTGRYTCVAV---NAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVE 2122 Query: 1003 LLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDE 1062 LLC+ D+ PP L L G P P L +++ N L+I A ++D Sbjct: 2123 LLCQSDAIPPPTLTWLKD-----------GHPLLKKPGL--SISENRSVLKIEDAQVQDT 2169 Query: 1063 GVYICEASNTLGQASASADFDAQAVNVQVWPGA---------TVREGQLVNLTCLVWTTH 1113 G Y CEA+N G+ + + VN+ V P TV EG L++L C Sbjct: 2170 GRYTCEATNVAGKTEKNYN-----VNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIP 2224 Query: 1114 PAQLTYTWYQDGQQRLD-----------AHSIPLPNVTVRDATSYRCGVGPPGRAPRLSR 1162 P L W + G L + + DA Y C A + Sbjct: 2225 PPNLI--WKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVAS--NVAGTAKK 2280 Query: 1163 PITLDVLYAPR----NLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAA 1218 L V P T ++ + G ++L C V PP + G L + Sbjct: 2281 EYNLQVYIRPTITNSGSHPTEIIVTRGKSISLE-CEVQGIPPPTVTWMKDGHPLIKAKGV 2339 Query: 1219 SVPNTLR-LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL----APE-AAVP 1272 + + L+L+ D G Y C A + G + +L + I+ +PE +V Sbjct: 2340 EILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVV 2399 Query: 1273 EGAPITVTCADPAAHAPTLYTWYHNG---------RWLQEGPAASLSFLVATRAHAGAYS 1323 E +++TC P++ TW+ +G R L G L + T AG Y+ Sbjct: 2400 EKNSVSLTCEASGIPLPSI-TWFKDGWPVSLSNSVRILSGG--RMLRLMQTTMEDAGQYT 2456 Query: 1324 CQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSM--AVIQCTVDSEPPAELALSH 1381 C ++A G + L VL P ++ D + + + C V P E+ Sbjct: 2457 CVVRNAAG-EERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHK 2515 Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQ 1441 DG+ L H + SG +Q+ VQ G Y C A + G S L Sbjct: 2516 DGQPLQEDEA-HHIISGGRFLQITN------VQVPHTG--RYTCLASSPAGHKSRSFSLN 2566 Query: 1442 VEGARVVAEPGLDV-PEGAA--LNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP----VP 1494 V + +A G D PE LN L+ +T WF + L + +P Sbjct: 2567 VFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILP 2626 Query: 1495 ---TLAFTHVARAQAGMYHCLAELPTGAAAS--------APVMLRV-LYPPKTPTMMVFV 1542 TL + AG Y C+A G P++ + L+ P V + Sbjct: 2627 GGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKI 2686 Query: 1543 EPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEA 1602 + L L+C + P ASL+ + G P + HV + N + I+ Sbjct: 2687 KVNNTLT--LECEAYAIPSASLSWY----------KDGQPLKSDDHVNIAANGHTLQIKE 2734 Query: 1603 LRPSDQGEYICSASNVLG 1620 + SD G Y C ASN+ G Sbjct: 2735 AQISDTGRYTCVASNIAG 2752 Score = 170 bits (431), Expect = 1e-41 Identities = 355/1578 (22%), Positives = 568/1578 (35%), Gaps = 297/1578 (18%) Query: 214 ILRCQLS--VANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAV 271 + RC + +H+ + E+ + V K + S R ++ + V L C N Sbjct: 1802 LYRCMAANTAGDHKKEFEVTVHVPPTIKSSGL----SERVVVKYKPVALQCIANGI--PN 1855 Query: 272 SSIKWLKD---------GVRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLH 322 SI WLKD +++Q+ VL + + DAG YTC A N G I LH Sbjct: 1856 PSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGE-TQQHIQLH 1914 Query: 323 IFMAEVQVSPAGPILENQTVTLVCN--------TPNEAPSDLRYSWYKNHVLLEDAHSHT 374 + + AG +L N+TV LV N N P +WYK++ LL + S T Sbjct: 1915 VH-EPPSLEDAGKML-NETV-LVSNPVQLECKAAGNPVPV---ITWYKDNRLLSGSTSMT 1968 Query: 375 -------LRLHLATRADTGFYFCEVQNVHG----------------SERSGPVSVVVNHP 411 + + A +D G Y C N G S + V+VVVN+P Sbjct: 1969 FLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNP 2028 Query: 412 PLTPVLTAFLETQA------GLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRF 465 LE +A L + S VS L + GG ILA TS Sbjct: 2029 -------VRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSA-------- 2073 Query: 466 SGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA--AEVVE 523 + +D+G Y C A N+ G +D ++ V+ Sbjct: 2074 ----------------QISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLI 2117 Query: 524 GQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPG-------SSLLLPAASSTDAGSYHCR 576 QAV L C+S P P +W +G L + PG S L + A D G Y C Sbjct: 2118 SQAVELLCQSDAIPPP--TLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCE 2175 Query: 577 ARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQL 636 A + +G + ++ P P +L G LLC PP L Sbjct: 2176 AT---NVAGKTEKNYNVNIWVP--PNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIW 2230 Query: 637 LHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG 696 K V T R+++ L++ I + LY C ASN G Sbjct: 2231 KKKGSPVLTD------------SMGRVRILSGGRQLQISIAEK--SDAALYSCVASNVAG 2276 Query: 697 NASTSATFNGQATV---LAIAPSHTLQ----EGTEANLTCNVSREAAGSPANFSWFRNG- 748 A +N Q + + + SH + G +L C V P +W ++G Sbjct: 2277 TAKKE--YNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQ---GIPPPTVTWMKDGH 2331 Query: 749 -VLWAQG-----PLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPD---RP 799 ++ A+G + L + +D Y C + AG LSV PP Sbjct: 2332 PLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAG-MTDKKYDLSVHAPPSIIGNH 2390 Query: 800 KLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSL 859 + + + + + C PL + F ++ S ++ S GR Sbjct: 2391 RSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRM--------- 2441 Query: 860 KLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSP---------SPELQEGQ 910 L + + + D+G Y C N G ++ G V V P +++E Q Sbjct: 2442 -LRLMQTTMEDAGQYTCVVRNAAGEER-----KIFGLSVLVPPHIVGENTLEDVKVKEKQ 2495 Query: 911 AVVLSCQVHTG--VPEGTSYRWYRDGQPLQESTSATL----RFAAITLTQ---AGAYHCQ 961 +V L+C+V TG VPE T W++DGQPLQE + + RF IT Q G Y C Sbjct: 2496 SVTLTCEV-TGNPVPEIT---WHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCL 2551 Query: 962 AQAP-GSATTSLAAPISLHVSYA-------PRHVTLTTLMDTGPGRLGLLLCRVDSDPPA 1013 A +P G + S + + + + A P VT+ T L+C S PPA Sbjct: 2552 ASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTS------LVCEAYSYPPA 2605 Query: 1014 QLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTL 1073 + T G P S+ ++ + P L+I A ++ G Y C A+N Sbjct: 2606 TI-----------TWFKDGTPLESN--RNIRILPGGRTLQILNAQEDNAGRYSCVATNEA 2652 Query: 1074 GQASASADFDAQAVNV----QVW-PGATVREGQL-----VNLTCLVWTTHPAQLTYTWYQ 1123 G+ + + +W PG + +E ++ + L C + A L +WY+ Sbjct: 2653 GEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASL--SWYK 2710 Query: 1124 DGQQ---------RLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRN 1174 DGQ + H++ + + D Y C L + + V + + Sbjct: 2711 DGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQK 2770 Query: 1175 L-RLTYLLES-HGGQLALVL--------CTVDSRPPAQLALSHAGRLLASSTAASV-PNT 1223 L + +L++ G+ V+ C ++ PP L G L SS + P Sbjct: 2771 LWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGG 2830 Query: 1224 LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVT--- 1280 L++ + D G Y+C A + G+ + ++R+ +I + +PE + V Sbjct: 2831 RVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSA 2890 Query: 1281 ---CADPAAHAPTLYTWYHNGRWLQE-------GPAASLSFLVATRAHAGAYSCQAQDAQ 1330 C + AP +W +G+ L E L L G Y C A++ Sbjct: 2891 LIECLSSGSPAPR-NSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTA 2949 Query: 1331 GTRSSRPAALQVLYAPQDAV--LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLAT 1388 G S++ ++ P + S + + C V PP +L+ + + + Sbjct: 2950 G--SAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKL 3007 Query: 1389 SSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV 1448 ++ + G +R +V D Y C A N G L V + Sbjct: 3008 NTNTLIVPGGR-----TLQIIRAKVSD----GGEYTCIAINQAGESKKKFSLTVYVPPSI 3058 Query: 1449 AEPG------LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRL----HAEPVPTLAF 1498 + ++V EG +++L C P PV W+ N R + H E + Sbjct: 3059 KDHDSESLSVVNVREGTSVSLECESNAVPPPV----ITWYKNGRMITESTHVEILADGQM 3114 Query: 1499 THVARAQ---AGMYHCLAELPTGAAASAPVMLRVLYPP--KTPTMMVFVEPEGGLRGILD 1553 H+ +A+ G Y C A + L V PP + P V VE L Sbjct: 3115 LHIKKAEVSDTGQYVCRA-INVAGRDDKNFHLNVYVPPSIEGPEREVIVETISN-PVTLT 3172 Query: 1554 CRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYIC 1613 C P ++ + + +S + V ++ I + SD G Y C Sbjct: 3173 CDATGIPPPTIAWLKNHKRIENSD--------SLEVRILSGGSKLQIARSQHSDSGNYTC 3224 Query: 1614 SASNVLGSASTSTYFGVR 1631 ASN+ G A + ++ Sbjct: 3225 IASNMEGKAQKYYFLSIQ 3242 Score = 168 bits (425), Expect = 5e-41 Identities = 361/1530 (23%), Positives = 537/1530 (35%), Gaps = 288/1530 (18%) Query: 250 RNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVL--------HLPQAAWSDAG 301 ++++ ++L C+ N++ P ++ W KDG L + VL +P+A DAG Sbjct: 2787 KDVIINNPISLYCETNAAPPP--TLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAG 2844 Query: 302 VYTCQAENGVGS--------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVC-NTPNEA 352 YTC A N G ++ PPI I A + +L N++ + C ++ + A Sbjct: 2845 RYTCVAVNEAGEDSLQYDVRVLVPPI---IKGANSDLPEEVTVLVNKSALIECLSSGSPA 2901 Query: 353 PSDLRYSWYKN-HVLLEDAH------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVS 405 P R SW K+ LLED H L++ D G Y C +N GS + + Sbjct: 2902 P---RNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKY-FN 2957 Query: 406 VVVNHPP---------LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTS 456 + V+ PP LT V+ F+ L C V P L S Sbjct: 2958 LNVHVPPSVIGPKSENLTVVVNNFIS--------LTCEVSGFPPPDL------------S 2997 Query: 457 GDSDHSPRFSGTSG---PNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARL 513 + P T+ P L+I + +D GEY C A N G + Sbjct: 2998 WLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS 3057 Query: 514 LISPAAE------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP-------GSSL 560 + +E V EG +V+L C S P P +WY NG ++ E G L Sbjct: 3058 IKDHDSESLSVVNVREGTSVSLECESNAVPPPV--ITWYKNGRMITESTHVEILADGQML 3115 Query: 561 LLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRG 620 + A +D G Y CRA + A L V PP + ++ Sbjct: 3116 HIKKAEVSDTGQYVCRAIN--VAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPV---- 3169 Query: 621 LLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPL 680 L C PP + L + + S ++V +++I Sbjct: 3170 TLTCDATGIPPPTIAWLKNHKRIENS--------------DSLEVRILSGGSKLQIARSQ 3215 Query: 681 LEEEGLYLCEASNALGNASTSATFNGQ---ATVLAIAPSH-TLQEGTEANLTCNVSREAA 736 + G Y C ASN G A + Q + A PS ++ G L CN A Sbjct: 3216 HSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCN----AN 3271 Query: 737 GSPANF-SWFRNGVLWAQGPLE---------TVTLLPVARTDAALYACRILTEAGAQLST 786 G P W ++G A G E T+ + +D Y C AG + Sbjct: 3272 GIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEE-DR 3330 Query: 787 PVLLSVLYPP-------DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATS 839 L+V P + KL L+D C P + + L Sbjct: 3331 IFNLNVYVTPTIRGNKDEAEKLMTLVDTSIN----IECRATGTPPPQI------NWLKNG 3380 Query: 840 LGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQ 899 L + SH R A + + + + D Y C A+N G N QV A Sbjct: 3381 LPLPLSSHIRLLAAGQV----IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVF-APPN 3435 Query: 900 VSPSPELQE-----GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLT- 953 + S +E G + ++C + G P S W RDGQPL T+ + L Sbjct: 3436 MDNSMGTEEITVLKGSSTSMAC-ITDGTP-APSMAWLRDGQPLGLDAHLTVSTHGMVLQL 3493 Query: 954 ------QAGAYHCQAQAPGSATTS---LAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLL 1004 +G Y C A + L H++ + H ++ +++ L Sbjct: 3494 LKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLE----LT 3549 Query: 1005 CRVDSDPPAQLRLLHGDRLVAST--LQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDE 1062 C P ++ + R + T +Q +GG E L I A +ED Sbjct: 3550 CIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEV---------------LRISTAQVEDT 3594 Query: 1063 GVYICEASNTLGQASASADFDAQAVNVQVWPGA---------TVREGQLVNLTCLVWTTH 1113 G Y C AS+ G D V V V P TV + V L C Sbjct: 3595 GRYTCLASSPAGD-----DDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVP 3649 Query: 1114 PAQLTYTWYQDGQQRLDA----------HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRP 1163 P +T W ++G+ RL A + + N + D +Y C A + +R Sbjct: 3650 PPVIT--WLRNGE-RLQATPRVRILSGGRYLQINNADLGDTANYTCVAS--NIAGKTTRE 3704 Query: 1164 ITLDVLYAPRNLRLTYLLESHGGQLALVL---------CTVDSRPPAQLALSHAGRLLAS 1214 L V P N++ GG +LV+ C + P ++ G +LA Sbjct: 3705 FILTV-NVPPNIK--------GGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAG 3755 Query: 1215 STAA-SVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP---EAA 1270 + A S+ L ++ D G Y C A + G ++L++ V +AP Sbjct: 3756 NHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVH-VPPSIAPGPTNMT 3814 Query: 1271 VPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGP---------AASLSFLVATRAHAGA 1321 V T+ C P++ W NG L + SL + + Sbjct: 3815 VIVNVQTTLACEATGIPKPSI-NWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTAT 3873 Query: 1322 YSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSH 1381 Y C + G R L V P A + + AVI CT P + + Sbjct: 3874 YECTVTNGAGD-DKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTK 3932 Query: 1382 DG-KVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRL 1440 +G ++L G L+SG + L Q AG Y C A+N GS L Sbjct: 3933 NGIRLLPRGDGYRILSSGAIEI--------LATQLNHAG--RYTCVARNAAGSAHRHVTL 3982 Query: 1441 QVEGARVVA-EPG-LDVPEGAALNLSCRLLGGPGPVGNSTFAW------FWNDRRLHAE- 1491 V V+ +P L V + L C G P P W R HA Sbjct: 3983 HVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPF----ITWQKEGINVNTSGRNHAVL 4038 Query: 1492 PVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPK-TPTMMVFV----EPEG 1546 P L + R AG Y C+A+ P G A + L V PP +P + +V +P Sbjct: 4039 PSGGLQISRAVREDAGTYMCVAQNPAGTALGK-IKLNVQVPPVISPHLKEYVIAVDKPI- 4096 Query: 1547 GLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPS 1606 L C D P +T H R + S Q VL+S + + I ++P Sbjct: 4097 ----TLSCEADGLPPPDITWHKDGRAIVESIRQ--------RVLSSGS---LQIAFVQPG 4141 Query: 1607 DQGEYICSASNVLGSASTSTYFGVRALHRL 1636 D G Y C A+NV GS+STST V R+ Sbjct: 4142 DAGHYTCMAANVAGSSSTSTKLTVHVPPRI 4171 Score = 164 bits (416), Expect = 5e-40 Identities = 330/1485 (22%), Positives = 537/1485 (36%), Gaps = 233/1485 (15%) Query: 251 NILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV--------LHLPQAAWSDAGV 302 N+ G V+L C+ N+ P V I W K+G + T V LH+ +A SD G Sbjct: 3070 NVREGTSVSLECESNAVPPPV--ITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQ 3127 Query: 303 YTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILE---NQTVTLVCNTPNEAPSDLRYS 359 Y C+A N G L++++ P ++ + VTL C+ P + + Sbjct: 3128 YVCRAINVAGR-DDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTI--A 3184 Query: 360 WYKNHVLLEDAHS---------HTLRLHLATRADTGFYFCEVQNVHG-SERSGPVSVVVN 409 W KNH +E++ S L++ + +D+G Y C N+ G +++ +S+ V Sbjct: 3185 WLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVP 3244 Query: 410 HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTS 469 + + + G L C+ P + G +AS G+++ R S Sbjct: 3245 PSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIAS--GETERI-RVSA-- 3299 Query: 470 GPNSLRLEIRDLEETDSGEYKCSATNSLGN----------ATSTLDFHANAARLLISPAA 519 N L I +D+G+Y C ATN G T T+ + + A L++ Sbjct: 3300 --NGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMT--- 3354 Query: 520 EVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP-------GSSLLLPAASSTDAGS 572 + ++ + CR+ + TP + +W NG L G + + A +D Sbjct: 3355 --LVDTSINIECRA--TGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAV 3410 Query: 573 YHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPA 632 Y C A + A + L V PP ++ G + C D P Sbjct: 3411 YTCVA--SNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVL---KGSSTSMACITDGTPAP 3465 Query: 633 RLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEAS 692 + L + + L + ST G LL+ E E+ G Y C AS Sbjct: 3466 SMAWLRDGQPLG--LDAHLTVSTHG---------MVLQLLKAET-----EDSGKYTCIAS 3509 Query: 693 NALGNASTSATFNGQATVLAIAPSHT--LQEGTEANLTCNVSRE----AAGSPA-NFSWF 745 N G S + P H +E E ++ N E A+G PA +W Sbjct: 3510 NEAGEVSKHFILK------VLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWM 3563 Query: 746 RNGVLWAQ-------GPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPP-- 796 ++G Q G E + + D Y C + AG L+ V PP Sbjct: 3564 KDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDD-DKEYLVRVHVPPNI 3622 Query: 797 ---DRPKLSALLDMGQGHMALFICTVDSRPLALLA-LFHGEHLLATSLGPQVPSHGRFQA 852 D P+ +L + C D+ P ++ L +GE L AT ++ S GR+ Sbjct: 3623 AGTDEPRDITVL---RNRQVTLECKSDAVPPPVITWLRNGERLQATPR-VRILSGGRY-- 3676 Query: 853 KAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPE---LQEG 909 L++ LGD+ +Y C A+N+ G + V + P+ + Sbjct: 3677 --------LQINNADLGDTANYTCVASNIAGKTTREFILTVNVP-PNIKGGPQSLVILLN 3727 Query: 910 QAVVLSCQVHTGVPEGTSYRWYRDGQPLQES-------TSATLRFAAITLTQAGAYHCQA 962 ++ VL C + GVP W +DG L + + L + +T G Y C A Sbjct: 3728 KSTVLEC-IAEGVPT-PRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMA 3785 Query: 963 -QAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGD 1021 A G+ + + + S AP +T +++ L C P + Sbjct: 3786 TNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQT----TLACEATGIPKPSINWRKNG 3841 Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAML------EDEGVYICEASNTLGQ 1075 L L+V N+ RL G+++ +D Y C +N G Sbjct: 3842 HL-----------------LNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGD 3884 Query: 1076 ASASADFDAQA-----------VNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQD 1124 + D Q + + P V + WT + +L D Sbjct: 3885 DKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRG--D 3942 Query: 1125 GQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV----LYAPRNLRLTYL 1180 G + L + +I + + A Y C A R +TL V + P+ L + Sbjct: 3943 GYRILSSGAIEILATQLNHAGRYTCVAR--NAAGSAHRHVTLHVHEPPVIQPQPSELHVI 4000 Query: 1181 LESHGGQLALVLCTVDSRPPAQLALSHAG-RLLASSTAASVPNTLRLELRGPQPRDEGFY 1239 L + L+ C P + G + S +V + L++ D G Y Sbjct: 4001 LNNP----ILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTY 4056 Query: 1240 SCSARSPLGQANTSLELRLEGVRVILAP---EAAVPEGAPITVTCADPAAHAPTLYTWYH 1296 C A++P G A ++L ++ V +++P E + PIT++C P + TW+ Sbjct: 4057 MCVAQNPAGTALGKIKLNVQ-VPPVISPHLKEYVIAVDKPITLSCEADGLPPPDI-TWHK 4114 Query: 1297 NGRWLQEG------PAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAV 1350 +GR + E + SL AG Y+C A + G+ SS L V P+ Sbjct: 4115 DGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGS-SSTSTKLTVHVPPRIRS 4173 Query: 1351 LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR 1410 S A++ C D P + D +LA G ++ A Sbjct: 4174 TEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYT----------AEPYGE 4223 Query: 1411 LQVQDVPAGDDT-YVCTAQNLLGSISTIGRLQVEGARVVAE-PG-LDVPEGAALNLSCRL 1467 L +++V D Y C A N G + L V E PG + + +G L LSC+ Sbjct: 4224 LILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKA 4283 Query: 1468 LGGPGPVGNSTFAWFWNDRRL--HAEPV---PTLAFTHVARAQAGMYHCLAELPTGAAAS 1522 G P P W +N+ + H + V L V++ +G Y C AE G Sbjct: 4284 TGIPLP----KLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFV-K 4338 Query: 1523 APVMLRVLYPP--KTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQG 1580 A + V PP K ++EP GG IL+C V +P ++ + + S Sbjct: 4339 AIGFVYVKEPPVFKGDYPSNWIEPLGG-NAILNCEVKGDPTPTIQWNRKGVDIEISHRIR 4397 Query: 1581 APAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTS 1625 + + + N D G+Y C A+N G S Sbjct: 4398 QLGNGSLAIYGTVN-----------EDAGDYTCVATNEAGVVERS 4431 Score = 162 bits (411), Expect = 2e-39 Identities = 366/1673 (21%), Positives = 582/1673 (34%), Gaps = 308/1673 (18%) Query: 99 NLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDF 158 +L LK ++ D+G Y+ SE S +TV E P+V + G+EV Sbjct: 575 SLELKSVKFNDAGEYHCMVS-SEGG--SSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSI 631 Query: 159 NCS-TPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRC 217 CS T Y + ++ W D S ++ T G TL + + I C Sbjct: 632 MCSATGY----PKPKIAWTVND---MFIVGSHRYRMTSDG---TLFIKNAAPKDAGIYGC 681 Query: 218 QLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWL 277 S + + L+ AP K+++ S + G++ + C+ + P +KW Sbjct: 682 LASNSAGTDKQNSTLRYIEAP---KLMVVQSELLVALGDITVMECKTSGIPP--PQVKWF 736 Query: 278 KDGVRLQTKT--------GVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQ 329 K + L+ T G+L + + DAG YTC A N G + I+L + V Sbjct: 737 KGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGR-ATGKITLDVGSPPVF 795 Query: 330 V-SPAGPILE-NQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRA---- 383 + PA +E VTL C +++ N + S + L T A Sbjct: 796 IQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFIL 855 Query: 384 -----DTGFYFCEVQNVHGSERS-GPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVS 437 D G Y CE +N G +S V+V PL + + G L C++++ Sbjct: 856 NLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLA 915 Query: 438 -EPLA-------TLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEY 489 P+ + +L +I + G L I ++ D GEY Sbjct: 916 GNPIPERRWIKNSAMLLQNPYITVRSDGS-----------------LHIERVQLQDGGEY 958 Query: 490 KCSATNSLG--NATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYL 547 C A+N G N T+++ H +EG VTL C++ +P P W Sbjct: 959 TCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSV--IWSK 1016 Query: 548 NGALL-------HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQ 600 G L+ G SL + + ++G Y C A ++A LTV PR Sbjct: 1017 KGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTAT--NTAGYAKRKVQLTVYVRPRV 1074 Query: 601 PTFTTRLDLD---AAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVA------TSLPSGG 651 L D AG L C V S PP + + ++++ T LPSG Sbjct: 1075 FGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGS 1134 Query: 652 GCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQA-TV 710 MK+T+ + G+YLC A+N GN + + N Sbjct: 1135 -----------MKITETRT-----------SDSGMYLCVATNIAGNVTQAVKLNVHVPPK 1172 Query: 711 LAIAPSH-TLQEGTEANLTCNVSREAAGSPAN-FSWFRNGVLW-------AQGPLETVTL 761 + P H +Q G ++ CN A G+P +W + G P T+++ Sbjct: 1173 IQRGPKHLKVQVGQRVDIPCN----AQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSI 1228 Query: 762 LPVARTDAALYACRILTEAGAQLSTPVLLSVLYPP-----DRPKLSALLDMGQGHMALFI 816 +DA +Y C AG T + L V PP + P + + F Sbjct: 1229 DQATPSDAGIYTCVATNIAGTD-ETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFP 1287 Query: 817 CTVDSRPLALLALFH-GEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYR 875 C P + H G L G + G L + + D+G Y Sbjct: 1288 CPAKGTPKPTIKWLHNGRELTGREPGISILEDGTL----------LVIASVTPYDNGEYI 1337 Query: 876 CEATNVLGSSNTSLFFQVRGAWV----QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWY 931 C A N G++ +V V + + + Q L C+V G P WY Sbjct: 1338 CVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVE-GTP-SPIIMWY 1395 Query: 932 RDGQPLQESTS-------ATLRFAAITLTQAGAYHCQA-QAPGSA----TTSLAAPISLH 979 +D + ES++ L+ T AG Y C+A G++ + P ++ Sbjct: 1396 KDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTII 1455 Query: 980 VSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSP 1039 + P V++ D L C+V P + + + +G P Sbjct: 1456 GTNFPNEVSVVLNRDVA------LECQVKGTPFPDIHWFKDGKPLF-----LGDP----- 1499 Query: 1040 RLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVRE 1099 +V + L + A D+G Y C SN G+ A+ + + ++ +++ Sbjct: 1500 --NVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGK-------QAKDIKLTIYIPPSIKG 1550 Query: 1100 G-----------QLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS---------IPLPNV 1139 G L+ L C T TWY+DGQ + + + +P Sbjct: 1551 GNVTTDISVLINSLIKLEC--ETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRA 1608 Query: 1140 TVRDATSYRCGVG----------------PPGRAPRLSRPITLDVLYAPRNLRLTYLLES 1183 V D+ +Y C V PP L+ P+ V+ A LT ++ Sbjct: 1609 QVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAH---SLTLECKA 1665 Query: 1184 HGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSA 1243 G ++ D P + A+ +LE+ Q D G Y C A Sbjct: 1666 AGNPSPILTWLKDGVP-----------VKANDNIRIEAGGKKLEIMSAQEIDRGQYICVA 1714 Query: 1244 RSPLGQANTSLELRLEGVRVILAPEAAVPEGAPIT------------VTCADPAAHAPTL 1291 S G+ E+ +L P A EG T + C + PT+ Sbjct: 1715 TSVAGEKEIKYEVD------VLVPPAI--EGGDETSYFIVMVNNLLELDCHVTGSPPPTI 1766 Query: 1292 YTWYHNGRWLQEGP-------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLY 1344 W +G+ + E L A ++ G Y C A + G +V Sbjct: 1767 -MWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKE---FEVTV 1822 Query: 1345 APQDAVLSSFRDSRA---RSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGH 1401 + SS R +QC + P + D + + T+ G + S Sbjct: 1823 HVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRV 1882 Query: 1402 VQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAAL 1461 +Q+A+ L AG Y C A N G +L V + + G + E + Sbjct: 1883 LQIAKTLLE------DAG--RYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLV 1934 Query: 1462 N----LSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTL----AFTHVARAQ---AGMYH 1510 + L C+ G P PV W+ ++R L T + AQ AG+Y Sbjct: 1935 SNPVQLECKAAGNPVPV----ITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYK 1990 Query: 1511 CLAELPTGAAASAPVMLRVLYPPKT--PTMMVFVEPEGGLRGILDCRVDSEPLASLT-LH 1567 C+A + + A L+V P MV V +R L+C P SLT L Sbjct: 1991 CVA-INSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVR--LECEARGIPAPSLTWLK 2047 Query: 1568 LGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620 GS + + S + VL+ L + + + SD G Y C A N G Sbjct: 2048 DGSPVSSFSN--------GLQVLSGGRILA--LTSAQISDTGRYTCVAVNAAG 2090 Score = 152 bits (385), Expect = 2e-36 Identities = 356/1584 (22%), Positives = 556/1584 (35%), Gaps = 303/1584 (19%) Query: 199 LETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELV 258 L+ +H++ D GR + ++VA + L V P + SP +++ V Sbjct: 2350 LKNIHVS----DTGRYVCVAVNVAG-MTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSV 2404 Query: 259 TLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTCQAENG 310 +LTC+ S P + SI W KDG VR+ + +L L Q DAG YTC N Sbjct: 2405 SLTCEA-SGIP-LPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNA 2462 Query: 311 VGS---------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCN-TPNEAPSDLRYSW 360 G LV P I + +V+V E Q+VTL C T N P +W Sbjct: 2463 AGEERKIFGLSVLVPPHIVGENTLEDVKVK------EKQSVTLTCEVTGNPVP---EITW 2513 Query: 361 YKNHVLLEDAHSH-------TLRLHLATRADTGFYFCEVQNVHG-SERSGPVSVVVNHPP 412 +K+ L++ +H L++ TG Y C + G RS ++V V+ P Sbjct: 2514 HKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVS-PT 2572 Query: 413 LTPV--------LTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPR 464 + V +T L + LV C S P AT+ G T +S+ + R Sbjct: 2573 IAGVGSDGNPEDVTVILNSPTSLV----CEAYSYPPATITWFKDG-----TPLESNRNIR 2623 Query: 465 FSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLL---------I 515 P L+I + +E ++G Y C ATN G + ++ + Sbjct: 2624 IL----PGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGL 2679 Query: 516 SP-AAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHE-------GPGSSLLLPAASS 567 SP ++ +TL C + P A SWY +G L G +L + A Sbjct: 2680 SPKEVKIKVNNTLTLECEA--YAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQI 2737 Query: 568 TDAGSYHCRARDGHSASGPSSPAVLTVLYPPR-QPTFTTRLDLDAAGAGAGRRGL----- 621 +D G Y C A + A + + PP Q + LD G + + Sbjct: 2738 SDTGRYTCVA--SNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795 Query: 622 -LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPL 680 L C ++ PP L +KD TS KV P ++I Sbjct: 2796 SLYCETNAAPPPTL-TWYKDGHPLTSSD---------------KVLILPGGRVLQIPRAK 2839 Query: 681 LEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTE--ANLTCNVSREAAGS 738 +E+ G Y C A N G S + + L E N + + ++GS Sbjct: 2840 VEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGS 2899 Query: 739 PA-NFSWFRNGVLWAQGPLE-----------TVTLLPVARTDAALYACRILTEAGAQLST 786 PA SW ++G Q LE + +L TD Y C AG+ Sbjct: 2900 PAPRNSWQKDG----QPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGS-AKK 2954 Query: 787 PVLLSVLYPPD--RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQV 844 L+V PP PK L + ++L C V P L+ E + + + Sbjct: 2955 YFNLNVHVPPSVIGPKSENLTVVVNNFISL-TCEVSGFPPPDLSWLKNEQPIKLNTNTLI 3013 Query: 845 PSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPS- 903 GR L++ + D G Y C A N G S V V PS Sbjct: 3014 VPGGR----------TLQIIRAKVSDGGEYTCIAINQAGESKKKF-----SLTVYVPPSI 3058 Query: 904 ----------PELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST-------SATLR 946 ++EG +V L C+ + P + WY++G+ + EST L Sbjct: 3059 KDHDSESLSVVNVREGTSVSLECESNAVPPPVIT--WYKNGRMITESTHVEILADGQMLH 3116 Query: 947 FAAITLTQAGAYHCQA---QAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLL 1003 ++ G Y C+A L + + R V + T+ + L Sbjct: 3117 IKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNP-----VTL 3171 Query: 1004 LCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEG 1063 C PP + L + + +S L V + +L+I + D G Sbjct: 3172 TCDATGIPPPTIAWLKNHKRIE-----------NSDSLEVRILSGGSKLQIARSQHSDSG 3220 Query: 1064 VYICEASNTLGQAS----ASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTY 1119 Y C ASN G+A S ++ +V G+ V L C P L Sbjct: 3221 NYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNA-NGIPTPL-I 3278 Query: 1120 TWYQDGQQ---------RLDAH--SIPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLD 1167 W +DG+ R+ A+ ++ + D Y C P G R+ L+ Sbjct: 3279 QWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRI---FNLN 3335 Query: 1168 VLYAPR---NLRLTYLLESHGGQLALVLCTVDSRPPAQ---------LALSHAGRLLASS 1215 V P N L + + C PP Q L LS RLLA+ Sbjct: 3336 VYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAG 3395 Query: 1216 TAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP-------- 1267 + Q D Y+C A + G N L+ + AP Sbjct: 3396 QVIRIVRA--------QVSDVAVYTCVASNRAGVDNKHYNLQ------VFAPPNMDNSMG 3441 Query: 1268 --EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLS-------FLVATRAH 1318 E V +G+ ++ C AP++ W +G+ L ++S L A Sbjct: 3442 TEEITVLKGSSTSMACITDGTPAPSM-AWLRDGQPLGLDAHLTVSTHGMVLQLLKAETED 3500 Query: 1319 AGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV-----IQCTVDSEP 1373 +G Y+C A + G S+ L+VL P ++ + S+ V + C P Sbjct: 3501 SGKYTCIASNEAG-EVSKHFILKVLEPPH---INGSEEHEEISVIVNNPLELTCIASGIP 3556 Query: 1374 PAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDT--YVCTAQNLL 1431 ++ DG+ L + V +L G LR+ V +DT Y C A + Sbjct: 3557 APKMTWMKDGRPLPQTDQVQTLGGG--------EVLRISTAQV---EDTGRYTCLASSPA 3605 Query: 1432 GSISTIGRLQVEGARVVA---EP-GLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRR 1487 G ++V +A EP + V + L C+ P PV W N R Sbjct: 3606 GDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV----ITWLRNGER 3661 Query: 1488 LHAEPVPTL----AFTHVARAQAG---MYHCLAELPTGAAASAPVMLRVLYPPKT---PT 1537 L A P + + + A G Y C+A G + +L V PP P Sbjct: 3662 LQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAG-KTTREFILTVNVPPNIKGGPQ 3720 Query: 1538 MMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALR 1597 +V + + +L+C + P +T ++A + + + E Sbjct: 3721 SLVILLNKS---TVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGF---------- 3767 Query: 1598 VDIEALRPSDQGEYICSASNVLGS 1621 + I++ +D G Y+C A+N G+ Sbjct: 3768 LHIQSAHVTDTGRYLCMATNAAGT 3791 Score = 145 bits (366), Expect = 3e-34 Identities = 352/1654 (21%), Positives = 589/1654 (35%), Gaps = 263/1654 (15%) Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159 L +++ Q D+G Y I+E R G + P V I P ++ E+ N Sbjct: 757 LKIQETQDLDAGDYTC-VAINEAGR---ATGKITLDVGSPPV-FIQEPADV--SMEIGSN 809 Query: 160 CSTP-YVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLET--LHMAMSWQDHGRILR 216 + P YV + ++W+ D ++ S+ F + + L T L + W Sbjct: 810 VTLPCYVQGYPEPTIKWRRLD---NMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYI 866 Query: 217 CQLSVANHRAQSEIHLQVK--YAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSI 274 C+ + QSE + V AP I +SPS N++ G+ +TL C + + P + Sbjct: 867 CEAENQFGKIQSETTVTVTGLVAPL---IGISPSVANVIEGQQLTLPCTLLAGNP-IPER 922 Query: 275 KWLKDGVRLQTKT-------GVLHLPQAAWSDAGVYTCQAENGVGSL-VSPPISLHIFMA 326 +W+K+ L G LH+ + D G YTC A N G+ + + +H+ Sbjct: 923 RWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPT 982 Query: 327 EVQVSPAGPILENQTVTLVCNTP-NEAPSDLRYSWYKNHVLLEDAHSH-------TLRLH 378 +E VTL C N PS + W K L+ + + +L + Sbjct: 983 IQHGQQILSTIEGIPVTLPCKASGNPKPSVI---WSKKGELISTSSAKFSAGADGSLYVV 1039 Query: 379 LATRADTGFYFCEVQNVHG-SERSGPVSVVV------NHPPLTPVLTAFLETQAGLVGIL 431 ++G Y C N G ++R ++V V + L+ + AG L Sbjct: 1040 SPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTL 1099 Query: 432 HCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKC 491 C V S P + + ++ S SPR + + ++I + +DSG Y C Sbjct: 1100 PCEVKSLPPPIITWAKETQLI------SPFSPRHTFLPSGS---MKITETRTSDSGMYLC 1150 Query: 492 SATNSLGNATSTLDFHANA-ARLLISPA-AEVVEGQAVTLSCRSGLSPTPDARFSWYLNG 549 ATN GN T + + + ++ P +V GQ V + C + +P P +W G Sbjct: 1151 VATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLP--VITWSKGG 1208 Query: 550 A-LLHEG------PGSSLLLPAASSTDAGSYHCRAR------DGHSASGPSSPAVLTVLY 596 + +L +G P +L + A+ +DAG Y C A + P + L Sbjct: 1209 STMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLE 1268 Query: 597 PPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTC 656 PP TF R+ A +R C P ++ LH R + Sbjct: 1269 PPYNTTFQERV--------ANQRIEFPCPAKGTPKPTIKWLHNGRELT------------ 1308 Query: 657 GGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPS 716 G P + + + LL + P + G Y+C A N G + Sbjct: 1309 -GREPGISILEDGTLLVIASVTPY--DNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKE 1365 Query: 717 HTLQEGTEANLTCNVSREAAGSPAN-FSWFRNGV-LWAQGPLETVT------LLPVARTD 768 N N+ E G+P+ W+++ V + ++TV L D Sbjct: 1366 QVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPED 1425 Query: 769 AALYACRILTEAGAQ--------LSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVD 820 A Y+C+ + AG L P ++ +P + +S +L+ C V Sbjct: 1426 AGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNE---VSVVLNRD----VALECQVK 1478 Query: 821 SRPLALLALF-HGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEAT 879 P + F G+ L ++ G+ L ++ D G Y+C + Sbjct: 1479 GTPFPDIHWFKDGKPLFLGDPNVELLDRGQV----------LHLKNARRNDKGRYQCTVS 1528 Query: 880 NVLGSSNTSLFF------QVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRD 933 N G + ++G V+ + + L C+ G+P + WY+D Sbjct: 1529 NAAGKQAKDIKLTIYIPPSIKGG--NVTTDISVLINSLIKLECETR-GLPM-PAITWYKD 1584 Query: 934 GQPLQESTSA----------------------TLRFAAITLTQAGAYHCQAQAPGSATTS 971 GQP+ S+ A T A + T ++H P + Sbjct: 1585 GQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGN 1644 Query: 972 LAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGV 1031 LA P++ V A +LT L C+ +P L L Sbjct: 1645 LATPLNKQVVIAH---SLT------------LECKAAGNPSPILTWLKD----------- 1678 Query: 1032 GGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQV 1091 G P ++ + + +LEI A D G YIC A++ G+ + D Sbjct: 1679 GVPVKANDNIRIEAGGK--KLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIE 1736 Query: 1092 WPGAT----VREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ---------RLDAHSIPLPN 1138 T V L+ L C V + P T W +DGQ L+ + + Sbjct: 1737 GGDETSYFIVMVNNLLELDCHVTGSPPP--TIMWLKDGQLIDERDGFKILLNGRKLVIAQ 1794 Query: 1139 VTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSR 1198 V + YRC + +T+ V ++ L+ + +AL C + Sbjct: 1795 AQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVAL-QCIANGI 1853 Query: 1199 P-PAQLALSHAGRLLASSTAASVPNTLR-LELRGPQPRDEGFYSCSARSPLGQANTSLEL 1256 P P+ L + + + ++ R L++ D G Y+C A + G+ ++L Sbjct: 1854 PNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQL 1913 Query: 1257 R------LEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLS 1310 LE +L V P+ + C P + TWY + R L + S++ Sbjct: 1914 HVHEPPSLEDAGKMLNETVLVSN--PVQLECKAAGNPVPVI-TWYKDNRLL--SGSTSMT 1968 Query: 1311 FL---------VATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARS 1361 FL A + AG Y C A ++ G + +LQV AP + ++ + Sbjct: 1969 FLNRGQIIDIESAQISDAGIYKCVAINSAGA-TELFYSLQVHVAPSISGSNNMVAVVVNN 2027 Query: 1362 MAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD 1421 ++C P L DG +++ S + SG G + +A Q+ D Sbjct: 2028 PVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSG-GRILALTSA---QISDT----G 2079 Query: 1422 TYVCTAQNLLG--SISTIGRLQVEGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTF 1479 Y C A N G R+ V + E + V A+ L C+ P P T Sbjct: 2080 RYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPP----TL 2135 Query: 1480 AWFWNDRRLHAEPVPTL----AFTHVARAQ---AGMYHCLAELPTGAAASAPVMLRVLYP 1532 W + L +P ++ + + AQ G Y C A G + + P Sbjct: 2136 TWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAG-KTEKNYNVNIWVP 2194 Query: 1533 PK---TPTMMVFVEPEGGLRGILDCRVDSEPLASLT-LHLGSRLVASSQPQGAPAEPHIH 1588 P + + EG L +L C P +L GS ++ S + + Sbjct: 2195 PNIGGSDELTQLTVIEGNLISLL-CESSGIPPPNLIWKKKGSPVLTDSMGR-------VR 2246 Query: 1589 VLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622 +L+ L++ I SD Y C ASNV G+A Sbjct: 2247 ILSGGRQLQISI--AEKSDAALYSCVASNVAGTA 2278 Score = 141 bits (356), Expect = 5e-33 Identities = 361/1677 (21%), Positives = 590/1677 (35%), Gaps = 290/1677 (17%) Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKG-TLVTVTE--EPRVPTIASPVELLEGTEV 156 L + +L D G+Y E N++ ++ T VTVT P + S ++EG ++ Sbjct: 852 LFILNLWASDKGTYICEAE----NQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQL 907 Query: 157 DFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKF--------EPTGVGHLETLHMAMSW 208 C+ L P R NS G H+E + + Sbjct: 908 TLPCT-----------LLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQL---- 952 Query: 209 QDHGRILRCQLSVA--NHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNS 266 QD G +VA N++ S + + G +IL + + G VTL C+ + Sbjct: 953 QDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQIL------STIEGIPVTLPCKASG 1006 Query: 267 SYPAVSSIKWLKDGVRLQTKT--------GVLHLPQAAWSDAGVYTCQAENGVGSL---- 314 + S+ W K G + T + G L++ ++G Y C A N G Sbjct: 1007 N--PKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKV 1064 Query: 315 -VSPPISLHIFMAEVQVSPAGPI----LENQTVTLVCNTPNEAPSDLRYSWYKNHVLLED 369 ++ + +F + +S P+ L + VTL C + P + +W K L+ Sbjct: 1065 QLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPII--TWAKETQLISP 1122 Query: 370 AH-------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLE 422 S ++++ +D+G Y C N+ G+ V + V+ PP L+ Sbjct: 1123 FSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQA-VKLNVHVPPKIQRGPKHLK 1181 Query: 423 TQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLE 482 Q G + C+ PL + S GG + D +H S P+ L I Sbjct: 1182 VQVGQRVDIPCNAQGTPLPVITWSKGGSTMLV---DGEHH-----VSNPDGT-LSIDQAT 1232 Query: 483 ETDSGEYKCSATNSLGNATSTLDFHANAARLL--ISPA-----AEVVEGQAVTLSCRSGL 535 +D+G Y C ATN G + + H + + P E V Q + C + Sbjct: 1233 PSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKG 1292 Query: 536 SPTPDARFSWYLNGA-LLHEGPGSSLL-----LPAASST--DAGSYHCRARDGHSASGPS 587 +P P + W NG L PG S+L L AS T D G Y C A + +G + Sbjct: 1293 TPKPTIK--WLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVN---EAGTT 1347 Query: 588 SPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSL 647 ++ P P + + + L C V+ P + + + +KD V T Sbjct: 1348 ERKYNLKVHVP--PVIKDKEQVTNVSVLLNQLTNLFCEVEGTP-SPIIMWYKDNVQVTE- 1403 Query: 648 PSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQ 707 S ++ +L++ P E+ G Y C+A N G + + Sbjct: 1404 ------------SSTIQTVNNGKILKLFRATP--EDAGRYSCKAINIAGTSQKYFNIDVL 1449 Query: 708 ATVLAIAPSHTLQEGTEANLTCNVSREAAGSP-ANFSWFRNGV-LWAQGPL-------ET 758 I + + N + + G+P + WF++G L+ P + Sbjct: 1450 VPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV 1509 Query: 759 VTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICT 818 + L R D Y C + AG Q + + L++ PP + D+ +L Sbjct: 1510 LHLKNARRNDKGRYQCTVSNAAGKQ-AKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLE 1568 Query: 819 VDSRPLALLALF---HGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYR 875 ++R L + A+ G+ ++++S QA L + + DS +Y Sbjct: 1569 CETRGLPMPAITWYKDGQPIMSSS-----------QALYIDKGQYLHIPRAQVSDSATYT 1617 Query: 876 CEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQV---HTGVPEGTS----- 927 C NV G++ S V V P ++ A L+ QV H+ E + Sbjct: 1618 CHVANVAGTAEKSFH-------VDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPS 1670 Query: 928 --YRWYRDGQPLQ-------ESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISL 978 W +DG P++ E+ L + G Y C A + + + + + Sbjct: 1671 PILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSV-AGEKEIKYEVDV 1729 Query: 979 HVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSS 1038 V A T+ L L C V PP + L +L+ Sbjct: 1730 LVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLI-------------D 1776 Query: 1039 PRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVR 1098 R + N +L I A + + G+Y C A+NT G + V V V P T++ Sbjct: 1777 ERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFE-----VTVHVPP--TIK 1829 Query: 1099 EGQLVNLTCLVWTTHPAQL--------TYTWYQDGQQRLDAHS----------IPLPNVT 1140 L + + Q + TW +D Q A + + Sbjct: 1830 SSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTL 1889 Query: 1141 VRDATSYRCGVGPPGRAPRLSRPITLDVLYAP------RNLRLTYLLESHGGQLALVLCT 1194 + DA Y C A + I L V P + L T L+ S+ QL C Sbjct: 1890 LEDAGRYTCVA--TNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLV-SNPVQLE---CK 1943 Query: 1195 VDSRPPAQLALSHAGRLLASSTAASVPNTLRL-ELRGPQPRDEGFYSCSARSPLGQANTS 1253 P + RLL+ ST+ + N ++ ++ Q D G Y C A + G Sbjct: 1944 AAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELF 2003 Query: 1254 LELRLEGVRVILAPE--AAVPEGAPITVTCADPAAHAPTLYTW---------YHNGRWLQ 1302 L++ I AV P+ + C AP+L TW + NG + Sbjct: 2004 YSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSL-TWLKDGSPVSSFSNGLQVL 2062 Query: 1303 EGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSM 1362 G L+ A + G Y+C A +A G + R L+V Y P + + S S Sbjct: 2063 SG-GRILALTSAQISDTGRYTCVAVNAAGEKQ-RDIDLRV-YVPPNIMGEEQNVSVLISQ 2119 Query: 1363 AV-IQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD 1421 AV + C D+ PP L DG L G+ ++ N L+++D D Sbjct: 2120 AVELLCQSDAIPPPTLTWLKDGHPLLKKPGL----------SISENRSVLKIEDAQVQDT 2169 Query: 1422 -TYVCTAQNLLGSISTIGRLQV------EGARVVAEPGLDVPEGAALNLSCRLLGGPGPV 1474 Y C A N+ G + + G+ + + L V EG ++L C G P P Sbjct: 2170 GRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQ--LTVIEGNLISLLCESSGIPPP- 2226 Query: 1475 GNSTFAWFWNDRRLHAEPVPT--------------LAFTHVARAQAGMYHCLAELPTGAA 1520 W + PV T L + ++ A +Y C+A G A Sbjct: 2227 ---NLIW-----KKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTA 2278 Query: 1521 ASAPVMLRVLYPPKT-----PTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVAS 1575 + + P T PT ++ G L+C V P ++T + Sbjct: 2279 KKEYNLQVYIRPTITNSGSHPTEIIVTR---GKSISLECEVQGIPPPTVTWMKDGHPLIK 2335 Query: 1576 SQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRA 1632 ++ E HI + ++ + SD G Y+C A NV G V A Sbjct: 2336 AKGVEILDEGHI----------LQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHA 2382 Score = 138 bits (347), Expect = 5e-32 Identities = 344/1597 (21%), Positives = 547/1597 (34%), Gaps = 267/1597 (16%) Query: 146 SPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETL--- 202 S V + EGT V C + V P +T+ T H+E L Sbjct: 3067 SVVNVREGTSVSLECESNAV--------------PPPVITWYKNGRMITESTHVEILADG 3112 Query: 203 ---HMAMSW-QDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILP--GE 256 H+ + D G+ + ++VA R HL V Y P ++ P I+ Sbjct: 3113 QMLHIKKAEVSDTGQYVCRAINVAG-RDDKNFHLNV-YVPPSIE---GPEREVIVETISN 3167 Query: 257 LVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTCQ 306 VTLTC P +I WLK+ R++ + L + ++ SD+G YTC Sbjct: 3168 PVTLTCDATGIPPP--TIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCI 3225 Query: 307 AENGVG--------SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRY 358 A N G S+ PP +A ++ +L + V LVCN N P+ L Sbjct: 3226 ASNMEGKAQKYYFLSIQVPPS-----VAGAEIPSDVSVLLGENVELVCNA-NGIPTPL-I 3278 Query: 359 SWYKN---------HVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSE-RSGPVSVVV 408 W K+ + A+ TL ++ A +DTG Y C N G E R ++V V Sbjct: 3279 QWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYV 3338 Query: 409 NHPPLTPVLTAFLETQAGLVGILHCSVVSEPLAT-------------LVLSHGGHILAST 455 TP + + L+ ++ S+ E AT L L HI Sbjct: 3339 -----TPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLA 3393 Query: 456 SGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG--NATSTLDFHA--NAA 511 +G + I + +D Y C A+N G N L A N Sbjct: 3394 AGQV----------------IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMD 3437 Query: 512 RLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGA-------LLHEGPGSSLLLPA 564 + + V++G + +++C + +P P +W +G L G L L Sbjct: 3438 NSMGTEEITVLKGSSTSMACITDGTPAPS--MAWLRDGQPLGLDAHLTVSTHGMVLQLLK 3495 Query: 565 ASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLC 624 A + D+G Y C A + A S +L VL PP ++ L L Sbjct: 3496 AETEDSGKYTCIA--SNEAGEVSKHFILKVLEPPHINGSEEHEEISVIV----NNPLELT 3549 Query: 625 RVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEE 684 + S PA KD LP T GG +LR+ +E+ Sbjct: 3550 CIASGIPAPKMTWMKD---GRPLPQTDQVQTLGG----------GEVLRISTAQ--VEDT 3594 Query: 685 GLYLCEASNALGNASTSATFNGQATVLAIAPSH----TLQEGTEANLTCNVSREAAGSPA 740 G Y C AS+ G+ T+ + L C + A P Sbjct: 3595 GRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLEC---KSDAVPPP 3651 Query: 741 NFSWFRNGVLWAQGPLETVTLLPVART---------DAALYACRILTEAGAQLSTPVLLS 791 +W RNG P V +L R D A Y C + + + + +L+ Sbjct: 3652 VITWLRNGERLQATP--RVRILSGGRYLQINNADLGDTANYTC-VASNIAGKTTREFILT 3708 Query: 792 VLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQ 851 V PP+ L + + C + P + +LA + H R+ Sbjct: 3709 VNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGN-------HARYS 3761 Query: 852 AKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE--- 908 L ++ + D+G Y C ATN G+ + QV ++P P Sbjct: 3762 ILENGF---LHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVP-PSIAPGPTNMTVIV 3817 Query: 909 GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQES---------TSATLRFAAITLTQAGAYH 959 L+C+ TG+P+ S W ++G L +S +L + ++ Y Sbjct: 3818 NVQTTLACEA-TGIPK-PSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYE 3875 Query: 960 C---QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDP-PAQL 1015 C T L + ++ P +T ++ C P P+ Sbjct: 3876 CTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPA------VITCTASGVPFPSIH 3929 Query: 1016 RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQ 1075 +G RL+ P G R+ + A +EI L G Y C A N G Sbjct: 3930 WTKNGIRLL---------PRGDGYRILSSGA-----IEILATQLNHAGRYTCVARNAAGS 3975 Query: 1076 ASASADFDAQAVNVQVWPGATVREGQLVNLTCLVW-TTHPAQLTYTWYQDG--------- 1125 A V + P + L N L T TW ++G Sbjct: 3976 AHRHVTLHVHEPPV-IQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRN 4034 Query: 1126 QQRLDAHSIPLPNVTVRDATSYRC-GVGPPGRA-PRLSRPITLDVLYAPRNLRLTYLLES 1183 L + + + DA +Y C P G A ++ + + + +P ++ Sbjct: 4035 HAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDK 4094 Query: 1184 HGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSA 1243 + C D PP + GR + S V ++ L++ QP D G Y+C A Sbjct: 4095 P----ITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMA 4150 Query: 1244 RSPLGQANTSLELRLEGVRVILAPEA--AVPEGAPITVTCADPAAHAPTLYTWYHN---- 1297 + G ++TS +L + I + E V E + + C P + W + Sbjct: 4151 ANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAI-NWKKDNVLL 4209 Query: 1298 ----GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSS 1353 G++ E P L +G Y+C A +A G + +L V P L Sbjct: 4210 ANLLGKYTAE-PYGELILENVVLEDSGFYTCVANNAAG-EDTHTVSLTVHVLPTFTELPG 4267 Query: 1354 FRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQV 1413 + C P +L + + ++ S GH ++ R+ Sbjct: 4268 DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPA-----HFDSVNGHSELVIE--RVSK 4320 Query: 1414 QDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVA---EPGLDVPEGAALNLSCRLLGG 1470 +D TYVCTA+N +G + IG + V+ V P G L+C + G Sbjct: 4321 ED----SGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGD 4376 Query: 1471 PGPVGNSTFAW------FWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAP 1524 P P T W R+ +LA AG Y C+A G + Sbjct: 4377 PTP----TIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERS- 4431 Query: 1525 VMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAE 1584 + L + PP V G + IL+C+ EP ++T S Q + Sbjct: 4432 MSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITW--------SRQGHSISWD 4483 Query: 1585 PHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621 ++VL++ + D + D E+ C A N++GS Sbjct: 4484 DRVNVLSNNSLYIADAQ---KEDTSEFECVARNLMGS 4517 Score = 134 bits (337), Expect = 8e-31 Identities = 337/1500 (22%), Positives = 518/1500 (34%), Gaps = 233/1500 (15%) Query: 245 LSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV--------LHLPQAA 296 LSP I +TL C+ + A S+ W KDG L++ V L + +A Sbjct: 2679 LSPKEVKIKVNNTLTLECEAYAIPSA--SLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQ 2736 Query: 297 WSDAGVYTCQAENGVG--------SLVSPPISLHIF-----MAEVQVSPAGPILENQTVT 343 SD G YTC A N G ++ PP ++ + + A ++ N ++ Sbjct: 2737 ISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPIS 2796 Query: 344 LVCNTPNEAPSDLRYSWYKNHVLLEDAHS-------HTLRLHLATRADTGFYFCEVQNVH 396 L C T P L +WYK+ L + L++ A D G Y C N Sbjct: 2797 LYCETNAAPPPTL--TWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEA 2854 Query: 397 GSERSGPVSVVVNHPPLTPVLTAFLETQAGLV----GILHCSVVSEPLATLVLSHGGHIL 452 G E S V V PP+ + L + ++ ++ C P G L Sbjct: 2855 G-EDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPL 2913 Query: 453 ASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR 512 + DH S N L+I + + TD G Y C A N+ G+A + + + Sbjct: 2914 L----EDDHHKFLS-----NGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPP 2964 Query: 513 LLISPAAE---VVEGQAVTLSCRSGLSPTPDARFSWY-------LNGALLHEGPGSSLLL 562 +I P +E VV ++L+C P PD SW LN L G +L + Sbjct: 2965 SVIGPKSENLTVVVNNFISLTCEVSGFPPPD--LSWLKNEQPIKLNTNTLIVPGGRTLQI 3022 Query: 563 PAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLL 622 A +D G Y C A + A LTV PP + L G L Sbjct: 3023 IRAKVSDGGEYTCIAI--NQAGESKKKFSLTVYVPPSIKDHDSE-SLSVVNVREGTSVSL 3079 Query: 623 LCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLE 682 C ++ PP + R++ S +++ +L ++ + Sbjct: 3080 ECESNAVPPPVITWYKNGRMITE--------------STHVEILADGQMLHIK--KAEVS 3123 Query: 683 EEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEAN---LTCNVSREAAG-S 738 + G Y+C A N G + N P + T +N LTC +A G Sbjct: 3124 DTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTC----DATGIP 3179 Query: 739 PANFSWFRNGV-LWAQGPLETVTL-----LPVAR---TDAALYACRILTEAGAQLSTPVL 789 P +W +N + LE L L +AR +D+ Y C I + + Sbjct: 3180 PPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTC-IASNMEGKAQKYYF 3238 Query: 790 LSVLYPPD--RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSH 847 LS+ PP ++ + + + G +C + P L+ G + S Sbjct: 3239 LSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKD--------GKPIASG 3290 Query: 848 GRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQ 907 + + AN L + D+G Y C ATN G + ++ V V+P+ Sbjct: 3291 ETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEED-----RIFNLNVYVTPTIRGN 3345 Query: 908 EGQAVVLSCQVHTGV-----PEGT---SYRWYRDGQPLQEST-------SATLRFAAITL 952 + +A L V T + GT W ++G PL S+ +R + Sbjct: 3346 KDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQV 3405 Query: 953 TQAGAYHCQAQAPGSA-----TTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRV 1007 + Y C A + AP ++ S +T+ T + C Sbjct: 3406 SDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTS------MACIT 3459 Query: 1008 DSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYIC 1067 D P + L G P G H+ V+ + + L++ A ED G Y C Sbjct: 3460 DGTPAPSMAWLRD-----------GQPLGLD--AHLTVSTHGMVLQLLKAETEDSGKYTC 3506 Query: 1068 EASNTLGQASASADFDAQAVNVQVWPGATVRE--GQLVN----LTCLVWTTHPAQLTYTW 1121 ASN G+ S F + + G+ E +VN LTC+ + PA TW Sbjct: 3507 IASNEAGE--VSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIA-SGIPAP-KMTW 3562 Query: 1122 YQDGQ--------QRLDAHSI-PLPNVTVRDATSYRCGVGPPG------RAPRLSRPITL 1166 +DG+ Q L + + V D Y C P R+ P + Sbjct: 3563 MKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNI 3622 Query: 1167 DVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLA-LSHAGRLLASSTAASVPNTLR 1225 PR++ + Q+ L C D+ PP + L + RL A+ + Sbjct: 3623 AGTDEPRDITVL-----RNRQVTLE-CKSDAVPPPVITWLRNGERLQATPRVRILSGGRY 3676 Query: 1226 LELRGPQPRDEGFYSCSARSPLGQANTSLELRLE-GVRVILAPEAAVPEGAPITV-TCAD 1283 L++ D Y+C A + G+ L + + P++ V TV C Sbjct: 3677 LQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIA 3736 Query: 1284 PAAHAPTLYTWYHNGRWLQEGPA----ASLSFLVATRAH---AGAYSCQAQDAQGTRSSR 1336 P + TW +G L A FL AH G Y C A +A GT R Sbjct: 3737 EGVPTPRI-TWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGT-DRR 3794 Query: 1337 PAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHS-- 1394 LQV P A + + C P + +G +L +S Sbjct: 3795 RIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYR 3854 Query: 1395 -LASGTGHVQVARNALRLQVQDVPAGDD--TYVCTAQNLLGSISTIGRLQVEGARVVAEP 1451 L+SG+ V P+ DD TY CT N G L V+ +A+ Sbjct: 3855 LLSSGS------------LVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADE 3902 Query: 1452 GLD--VPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRL----HAEPVPTLAFTHVARAQ 1505 D V + A ++C G P P + W N RL + + + Q Sbjct: 3903 PTDFLVTKHAPAVITCTASGVPFP----SIHWTKNGIRLLPRGDGYRILSSGAIEILATQ 3958 Query: 1506 ---AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLA 1562 AG Y C+A G +A V L V PP + +L C P Sbjct: 3959 LNHAGRYTCVARNAAG-SAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSP 4017 Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622 +T V +S H + L++ A+R D G Y+C A N G+A Sbjct: 4018 FITWQKEGINVNTSGRN--------HAVLPSGGLQIS-RAVR-EDAGTYMCVAQNPAGTA 4067 Score = 133 bits (335), Expect = 1e-30 Identities = 317/1508 (21%), Positives = 545/1508 (36%), Gaps = 254/1508 (16%) Query: 243 ILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW--------LKDGVRLQTKTGV-LHLP 293 ++ P+ + PGE LTC + S+ ++ W L + R++T + L L Sbjct: 522 VIQVPNNVTVTPGERAVLTCLIISAVDY--NLTWQRNDRDVRLAEPARIRTLANLSLELK 579 Query: 294 QAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPIL-ENQT------VTLVC 346 ++DAG Y C + GS + +F+ VQ P ++ +NQ+ V+++C Sbjct: 580 SVKFNDAGEYHCMVSSEGGSSAAS-----VFLT-VQEPPKVTVMPKNQSFTGGSEVSIMC 633 Query: 347 NTPNEAPSDLRYSWYKNHVLLEDAHSH------TLRLHLATRADTGFYFCEVQNVHGSER 400 + + +W N + + +H + TL + A D G Y C N G+++ Sbjct: 634 SATGYPKPKI--AWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDK 691 Query: 401 SGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSD 460 + P L V + L G + ++ C P + GD + Sbjct: 692 QNSTLRYIEAPKLMVVQSELL-VALGDITVMECKTSGIPPPQVKWF---------KGDLE 741 Query: 461 HSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAE 520 P P L+I++ ++ D+G+Y C A N G AT + + + I A+ Sbjct: 742 LRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPAD 801 Query: 521 VVE--GQAVTLSCRSGLSPTPDAR---------FSWYLNGALLHEGPGSSLLLPAASSTD 569 V G VTL C P P + FS + + + + +L + ++D Sbjct: 802 VSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASD 861 Query: 570 AGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSD 629 G+Y C A + + +T L P + A G++ L C + + Sbjct: 862 KGTYICEAENQFGKIQSETTVTVTGLVAP-----LIGISPSVANVIEGQQLTLPCTLLAG 916 Query: 630 PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLC 689 P + K+ + +P + V +L I L++ G Y C Sbjct: 917 NPIPERRWIKNSAMLLQ-------------NPYITVRSDGSL---HIERVQLQDGGEYTC 960 Query: 690 EASNALG--NASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSP-ANFSWFR 746 ASN G N +TS + T+ + EG L C +A+G+P + W + Sbjct: 961 VASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPC----KASGNPKPSVIWSK 1016 Query: 747 NGVL-------WAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPP--- 796 G L ++ G ++ ++ ++ Y C AG V L+V P Sbjct: 1017 KGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAG-YAKRKVQLTVYVRPRVF 1075 Query: 797 --------DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHG 848 D+P ++L G C V S P ++ L++ P P H Sbjct: 1076 GDQRGLSQDKPVEISVL---AGEEVTLPCEVKSLPPPIITWAKETQLIS----PFSPRH- 1127 Query: 849 RFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR-GAWVQVSPSP-EL 906 S +++ E DSG Y C ATN+ G+ ++ V +Q P ++ Sbjct: 1128 -----TFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKV 1182 Query: 907 QEGQAVVLSCQVH-TGVPEGTSYRWYR-------DGQPLQESTSATLRFAAITLTQAGAY 958 Q GQ V + C T +P T W + DG+ + TL T + AG Y Sbjct: 1183 QVGQRVDIPCNAQGTPLPVIT---WSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIY 1239 Query: 959 HCQA-QAPGSATTSLAAPISLHVSYAPRHVTL-----TTLMDTGPGRLGLLLCRVDSDPP 1012 C A G+ T I+LHV P L TT + + C P Sbjct: 1240 TCVATNIAGTDETE----ITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPK 1295 Query: 1013 AQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNT 1072 ++ LH R + G+ E + + +V P D G YIC A N Sbjct: 1296 PTIKWLHNGRELTGREPGISILEDGTLLVIASVTP------------YDNGEYICVAVNE 1343 Query: 1073 LGQASASADFDAQAVNV----QVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQR 1128 G + V + +V QL NL C V T P+ + WY+D Q Sbjct: 1344 AGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGT-PSPI-IMWYKDNVQV 1401 Query: 1129 LDAHSIPLPN---------VTVRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLT 1178 ++ +I N T DA Y C + G + + +DVL P T Sbjct: 1402 TESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKY---FNIDVLVPP-----T 1453 Query: 1179 YLLESHGGQLALVL-------CTVDSRPPAQLALSHAGR--LLASSTAASVPNTLRLELR 1229 + + ++++VL C V P + G+ L + L L+ Sbjct: 1454 IIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLK 1513 Query: 1230 GPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVI----LAPEAAVPEGAPITVTCADPA 1285 + D+G Y C+ + G+ ++L + I + + +V + I + C Sbjct: 1514 NARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRG 1573 Query: 1286 AHAPTLYTWYHNGRWLQEGPAASL----SFLVATRAH---AGAYSCQAQDAQGTRSSRPA 1338 P + TWY +G+ + A +L RA + Y+C + GT + + Sbjct: 1574 LPMPAI-TWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGT-AEKSF 1631 Query: 1339 ALQVLYAPQ-DAVLSSFRDSR---ARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHS 1394 + V P + L++ + + A S+ ++C P L DG + + + Sbjct: 1632 HVDVYVPPMIEGNLATPLNKQVVIAHSL-TLECKAAGNPSPILTWLKDGVPVKANDNIRI 1690 Query: 1395 LASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLD 1454 A G + + Q++ G Y+C A ++ G + +V+ V+ P ++ Sbjct: 1691 EAGG-------KKLEIMSAQEIDRGQ--YICVATSVAGEKEI--KYEVD---VLVPPAIE 1736 Query: 1455 ---------VPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTH----V 1501 V L L C + G P P T W + + + + + Sbjct: 1737 GGDETSYFIVMVNNLLELDCHVTGSPPP----TIMWLKDGQLIDERDGFKILLNGRKLVI 1792 Query: 1502 ARAQ---AGMYHCLAELPTGAAASAPVMLRVLYPPK------TPTMMVFVEPEGGLRGIL 1552 A+AQ G+Y C+A T + V PP + ++V +P L Sbjct: 1793 AQAQVSNTGLYRCMA-ANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVA-----L 1846 Query: 1553 DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612 C + P S+T + QP A+ ++ + +S L++ L D G Y Sbjct: 1847 QCIANGIPNPSIT------WLKDDQPVNT-AQGNLKIQSSGRVLQIAKTLL--EDAGRYT 1897 Query: 1613 CSASNVLG 1620 C A+N G Sbjct: 1898 CVATNAAG 1905 Score = 133 bits (334), Expect = 2e-30 Identities = 283/1247 (22%), Positives = 453/1247 (36%), Gaps = 234/1247 (18%) Query: 213 RILRCQLS-------VANHRA---QSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTC 262 RI+R Q+S VA++RA +LQV +AP + + +L G ++ C Sbjct: 3399 RIVRAQVSDVAVYTCVASNRAGVDNKHYNLQV-FAPPNMDNSMGTEEITVLKGSSTSMAC 3457 Query: 263 QVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSL 314 + PA S+ WL+DG + + T VL L +A D+G YTC A N G Sbjct: 3458 -ITDGTPA-PSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGE- 3514 Query: 315 VSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNE---------APSDLRYSWYKNHV 365 +S H + ++ E++ ++++ N P E AP + +W K+ Sbjct: 3515 ----VSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAP---KMTWMKDGR 3567 Query: 366 LLEDAHS-------HTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPV-- 416 L LR+ A DTG Y C + G + + V P + Sbjct: 3568 PLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDE 3627 Query: 417 ---LTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNS 473 +T Q L C + P + G L +T PR SG Sbjct: 3628 PRDITVLRNRQV----TLECKSDAVPPPVITWLRNGERLQAT-------PRVRILSGGRY 3676 Query: 474 LRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAA-RLLISPAAEVVE-GQAVTLSC 531 L++ DL +T Y C A+N G T N + P + V+ ++ L C Sbjct: 3677 LQINNADLGDT--ANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLEC 3734 Query: 532 RSGLSPTPDARFSWYLNGALLHEG-------PGSSLLLPAASSTDAGSYHCRARDGHSAS 584 + PTP R +W +GA+L L + +A TD G Y C A + Sbjct: 3735 IAEGVPTP--RITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATN----- 3787 Query: 585 GPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVA 644 AAG R L + S P + V Sbjct: 3788 --------------------------AAGTDRRRIDLQVHVPPSIAPGPTNM-----TVI 3816 Query: 645 TSLPSGGGCSTCGGCSPRMKVTKAPNLLRVE---------------IHNPLLEEEGLYLC 689 ++ + C G P + K +LL V+ I +P +++ Y C Sbjct: 3817 VNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYEC 3876 Query: 690 EASNALGNASTSATFNGQATV-LAIAPSHTL-QEGTEANLTCNVSREAAGSP-ANFSWFR 746 +N G+ + Q +A P+ L + A +TC A+G P + W + Sbjct: 3877 TVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCT----ASGVPFPSIHWTK 3932 Query: 747 NGV----------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPP 796 NG+ + + G +E +L A Y C + A V L V PP Sbjct: 3933 NGIRLLPRGDGYRILSSGAIE---ILATQLNHAGRYTC-VARNAAGSAHRHVTLHVHEPP 3988 Query: 797 DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEA 856 + L + + L C P + G V + GR A + Sbjct: 3989 VIQPQPSELHVILNNPILLPCEATGTPSPFITW--------QKEGINVNTSGRNHAVLPS 4040 Query: 857 NSLKLE--VRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSP--SPELQE---- 908 L++ VRE D+G+Y C A N G++ + V QV P SP L+E Sbjct: 4041 GGLQISRAVRE----DAGTYMCVAQNPAGTALGKIKLNV-----QVPPVISPHLKEYVIA 4091 Query: 909 -GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQES------TSATLRFAAITLTQAGAYHCQ 961 + + LSC+ G+P W++DG+ + ES +S +L+ A + AG Y C Sbjct: 4092 VDKPITLSCEAD-GLPP-PDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCM 4149 Query: 962 A-QAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020 A GS++TS +++HV PR + +L C D P + Sbjct: 4150 AANVAGSSSTS--TKLTVHVP--PRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKD 4205 Query: 1021 DRLVASTL-QGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASAS 1079 + L+A+ L + P G L + +LED G Y C A+N G+ Sbjct: 4206 NVLLANLLGKYTAEPYGE--------------LILENVVLEDSGFYTCVANNAAGE---- 4247 Query: 1080 ADFDAQAVNVQVWPGAT-------VREGQLVNLTCLVWTTHPAQLTYTWYQD----GQQR 1128 D ++ V V P T + +G+ + L+C +LT+T+ + Sbjct: 4248 -DTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDS 4306 Query: 1129 LDAHS-IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY---LLESH 1184 ++ HS + + V+ D+ +Y C + + I + P + Y +E Sbjct: 4307 VNGHSELVIERVSKEDSGTYVC---TAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPL 4363 Query: 1185 GGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSAR 1244 GG A++ C V P + + G + S L + G D G Y+C A Sbjct: 4364 GGN-AILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVAT 4422 Query: 1245 SPLGQANTSLELRLEGVRVI-LAP-EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQ 1302 + G S+ L L+ +I L P E + G I + C PT+ TW G + Sbjct: 4423 NEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTI-TWSRQGHSIS 4481 Query: 1303 EGPAA------SLSFLVATRAHAGAYSCQAQDAQGTRSSR-PAALQV 1342 SL A + + C A++ G+ R P +QV Sbjct: 4482 WDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQV 4528 Score = 124 bits (310), Expect = 1e-27 Identities = 233/1018 (22%), Positives = 361/1018 (35%), Gaps = 170/1018 (16%) Query: 236 YAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV------ 289 + P + P +L VTL C+ ++ P V I WL++G RLQ V Sbjct: 3617 HVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV--ITWLRNGERLQATPRVRILSGG 3674 Query: 290 --LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSP---AGP----ILENQ 340 L + A D YTC A N G F+ V V P GP IL N+ Sbjct: 3675 RYLQINNADLGDTANYTCVASNIAGKTTRE------FILTVNVPPNIKGGPQSLVILLNK 3728 Query: 341 TVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHT-------LRLHLATRADTGFYFCEVQ 393 + L C E R +W K+ +L H+ L + A DTG Y C Sbjct: 3729 STVLECIA--EGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMAT 3786 Query: 394 NVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILA 453 N G++R + + V+ PP + + L C P ++ GH+L Sbjct: 3787 NAAGTDRRR-IDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLN 3845 Query: 454 STSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARL 513 + + SG+ L I D+ Y+C+ TN G+ T+D Sbjct: 3846 VDQNQNSYRLLSSGS-------LVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPS 3898 Query: 514 LISPAAE--VVEGQAVTLSCRSGLSPTPDARFSWYLNGA-LLHEGPGSSLL------LPA 564 + + V + ++C + P P W NG LL G G +L + A Sbjct: 3899 IADEPTDFLVTKHAPAVITCTASGVPFPSIH--WTKNGIRLLPRGDGYRILSSGAIEILA 3956 Query: 565 ASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLC 624 AG Y C AR+ +A L V PP + L + LL C Sbjct: 3957 TQLNHAGRYTCVARN--AAGSAHRHVTLHVHEPPVIQPQPSELHVIL-----NNPILLPC 4009 Query: 625 RVDSDPPARLQLLHKDRVVATS------LPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHN 678 P + + V TS LPSGG ++I Sbjct: 4010 EATGTPSPFITWQKEGINVNTSGRNHAVLPSGG----------------------LQISR 4047 Query: 679 PLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAG- 737 + E+ G Y+C A N G A N Q V + H + + +S EA G Sbjct: 4048 AVREDAGTYMCVAQNPAGTALGKIKLNVQ--VPPVISPHLKEYVIAVDKPITLSCEADGL 4105 Query: 738 SPANFSWFRNGV---------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPV 788 P + +W ++G + + G L+ + P DA Y C AG+ ST Sbjct: 4106 PPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQP---GDAGHYTCMAANVAGSS-STST 4161 Query: 789 LLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHG 848 L+V PP + + A+ C D P + LLA LG Sbjct: 4162 KLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLG------- 4214 Query: 849 RFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN--TSLFFQVRGAWVQVSPSPEL 906 ++ A+ +L + + L DSG Y C A N G SL V + ++ L Sbjct: 4215 KYTAEPYG---ELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSL 4271 Query: 907 QEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT-----LRFAAITLTQAGAYHCQ 961 +G+ + LSC+ TG+P W + + + L ++ +G Y C Sbjct: 4272 NKGEQLRLSCKA-TGIPL-PKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCT 4329 Query: 962 AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP-GRLGLLLCRVDSDPPAQLRLLHG 1020 A+ ++ + A ++V P P G +L C V DP ++ Sbjct: 4330 AE---NSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRK 4386 Query: 1021 --DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASA 1078 D ++ ++ +G GS L I+G + ED G Y C A+N G Sbjct: 4387 GVDIEISHRIRQLGN--GS--------------LAIYGTVNEDAGDYTCVATNEAGVVER 4430 Query: 1079 SADFDAQAVN-VQVWPGATV-REGQLVNLTCLVWTTHPAQLTYTWYQDGQ--------QR 1128 S Q+ + + P TV G + L C T Q T TW + G Sbjct: 4431 SMSLTLQSPPIITLEPVETVINAGGKIILNC--QATGEPQPTITWSRQGHSISWDDRVNV 4488 Query: 1129 LDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGG 1186 L +S+ + + D + + C ++R + VL +R+ +++ HGG Sbjct: 4489 LSNNSLYIADAQKEDTSEFEC----------VARNLMGSVL-----VRVPVIVQVHGG 4531 Score = 119 bits (299), Expect = 2e-26 Identities = 186/822 (22%), Positives = 304/822 (36%), Gaps = 99/822 (12%) Query: 855 EANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR--GAWVQVSPSPELQEGQAV 912 E+ S+ L++ ++ L D G Y C A + G+ FF V +QV + + G+ Sbjct: 478 ESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERA 537 Query: 913 VLSCQVHTGVPEGTSY----RWYRDGQPLQESTSA--TLRFAAITLTQAGAYHCQAQAPG 966 VL+C + + V ++ R R +P + T A +L ++ AG YHC + G Sbjct: 538 VLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEG 597 Query: 967 SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVAS 1026 S AA + L V P+ + G ++C P ++ D + Sbjct: 598 G---SSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVG 654 Query: 1027 TLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLG---QASASADFD 1083 + + +G+ L I A +D G+Y C ASN+ G Q S + Sbjct: 655 SHRYRMTSDGT--------------LFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIE 700 Query: 1084 AQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQ-DGQQRLDAHSIPLPNVTV- 1141 A + V V V G + + C P Q+ W++ D + R I P + + Sbjct: 701 APKLMV-VQSELLVALGDITVMECKTSGIPPPQV--KWFKGDLELRPSTFLIIDPLLGLL 757 Query: 1142 -------RDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLC 1193 DA Y C + GRA + ITLDV P ++ + G + C Sbjct: 758 KIQETQDLDAGDYTCVAINEAGRA---TGKITLDVGSPPVFIQEPADVSMEIGSNVTLPC 814 Query: 1194 TVDSRPPAQLALSHAGRLLASSTAASVPNTLRLE-----LRGPQPRDEGFYSCSARSPLG 1248 V P + + S SV + +L + D+G Y C A + G Sbjct: 815 YVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFG 874 Query: 1249 QANTSLELRLEGV---RVILAPEAA-VPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEG 1304 + + + + G+ + ++P A V EG +T+ C A + W N L + Sbjct: 875 KIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQN 934 Query: 1305 P------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSR 1358 P SL G Y+C A + GT +++ ++ V P + Sbjct: 935 PYITVRSDGSLHIERVQLQDGGEYTCVASNVAGT-NNKTTSVVVHVLPTIQHGQQILSTI 993 Query: 1359 ARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPA 1418 + C P + S G++++TSS S A G + V P Sbjct: 994 EGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFS-AGADGSLYVVS----------PG 1042 Query: 1419 GDDT--YVCTAQNLLGSISTIGRLQV----------EGARVVAEPGLDVPEGAALNLSCR 1466 G+++ YVCTA N G +L V G + V G + L C Sbjct: 1043 GEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCE 1102 Query: 1467 LLGGPGPV---GNSTFAWFWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASA 1523 + P P+ T R P ++ T + +GMY C+A G A Sbjct: 1103 VKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQA 1162 Query: 1524 PVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHL-GSRLVASSQPQGAP 1582 V L V PPK ++ + G R + C PL +T GS ++ + Sbjct: 1163 -VKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGE----- 1216 Query: 1583 AEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSAST 1624 H +++P+ + I+ PSD G Y C A+N+ G+ T Sbjct: 1217 -----HHVSNPDG-TLSIDQATPSDAGIYTCVATNIAGTDET 1252 Score = 113 bits (283), Expect = 1e-24 Identities = 284/1363 (20%), Positives = 495/1363 (36%), Gaps = 228/1363 (16%) Query: 367 LEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAG 426 L+++ S L + T +D GFY C + G+ R+ V PP+ V T G Sbjct: 476 LKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVT-PG 534 Query: 427 LVGILHCSVVSEPLATLVLSHGGHILASTSGDSD---HSPRFSGTSGPNSLRLEIRDLEE 483 +L C L++S + L D D P T +L LE++ ++ Sbjct: 535 ERAVLTC---------LIISAVDYNLTWQRNDRDVRLAEPARIRTLA--NLSLELKSVKF 583 Query: 484 TDSGEYKCSATNSLGNATSTLDFHA-NAARLLISPAAE-VVEGQAVTLSCRSGLSPTPDA 541 D+GEY C ++ G++ +++ ++ + P + G V++ C + P P Sbjct: 584 NDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKP-- 641 Query: 542 RFSWYLNGALL------HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVL 595 + +W +N + +L + A+ DAG Y C A +SA + L + Sbjct: 642 KIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLA--SNSAGTDKQNSTLRYI 699 Query: 596 YPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCST 655 P+ + L + G ++ C+ PP +++ D + Sbjct: 700 EAPKLMVVQSELLV-----ALGDITVMECKTSGIPPPQVKWFKGDLELRP---------- 744 Query: 656 CGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFN-GQATVLAIA 714 S + + LL+++ L + G Y C A N G A+ T + G V Sbjct: 745 ----STFLIIDPLLGLLKIQETQDL--DAGDYTCVAINEAGRATGKITLDVGSPPVFIQE 798 Query: 715 PSHTLQE-GTEANLTCNVS---------REAAGSP--------ANFSWFRNGVLWAQGPL 756 P+ E G+ L C V R P ++ S R G L+ Sbjct: 799 PADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALF----- 853 Query: 757 ETVTLLPVARTDAALYACRILTEAG-AQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALF 815 +L + +D Y C + G Q T V ++ L P ++ ++ +G Sbjct: 854 ----ILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTL 909 Query: 816 ICT-VDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSY 874 CT + P+ +L + V S G L + + L D G Y Sbjct: 910 PCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDG-----------SLHIERVQLQDGGEY 958 Query: 875 RCEATNVLGSSN--TSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYR 932 C A+NV G++N TS+ V EG V L C+ +G P+ S W + Sbjct: 959 TCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKA-SGNPK-PSVIWSK 1016 Query: 933 DGQPLQESTS-------ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPR 985 G+ + S++ +L + ++G Y C A T+ A YA R Sbjct: 1017 KGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTA-------TNTA-------GYAKR 1062 Query: 986 HVTLTTLMDT---GPGRLGLLLCRVDSDPPAQLRLLHGDRL-VASTLQGVGGPEGSSPRL 1041 V LT + G R + D P ++ +L G+ + + ++ + P + + Sbjct: 1063 KVQLTVYVRPRVFGDQR------GLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKE 1116 Query: 1042 HVAVAPNTLR--------LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWP 1093 ++P + R ++I D G+Y+C A+N G + A +NV V P Sbjct: 1117 TQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVT-----QAVKLNVHVPP 1171 Query: 1094 -------GATVREGQLVNLTCLVWTTHPAQLTY-----TWYQDGQQRLD--AHSIPLPNV 1139 V+ GQ V++ C T +T+ T DG+ + ++ + Sbjct: 1172 KIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQA 1231 Query: 1140 TVRDATSYRC------GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLC 1193 T DA Y C G + P T++ L P N T E Q C Sbjct: 1232 TPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYN---TTFQERVANQRIEFPC 1288 Query: 1194 TVDSRPPAQLALSHAGRLLASST--AASVPNTLRLELRGPQPRDEGFYSCSARSPLGQAN 1251 P + H GR L + + + L + P D G Y C A + G Sbjct: 1289 PAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTE 1348 Query: 1252 TSLELRLEGVRVILAPE----AAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAA 1307 L++ VI E +V + C +P + WY + + E Sbjct: 1349 RKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSP-IIMWYKDNVQVTESSTI 1407 Query: 1308 S-------LSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR 1360 L AT AG YSC+A + GT S + + VL P + ++F + + Sbjct: 1408 QTVNNGKILKLFRATPEDAGRYSCKAINIAGT-SQKYFNIDVL-VPPTIIGTNFPNEVSV 1465 Query: 1361 SM---AVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVP 1417 + ++C V P ++ DGK L G +V++ L +++ Sbjct: 1466 VLNRDVALECQVKGTPFPDIHWFKDGK---------PLFLGDPNVELLDRGQVLHLKNAR 1516 Query: 1418 AGD-DTYVCTAQNLLGSISTIGRL------QVEGARVVAEPGLDVPEGAALNLSCRLLGG 1470 D Y CT N G + +L ++G V + + V + + L C G Sbjct: 1517 RNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTD--ISVLINSLIKLECETRGL 1574 Query: 1471 PGPVGNSTFAWFWNDRRL----HAEPVPTLAFTHVARAQ---AGMYHCLAELPTGAAASA 1523 P P W+ + + + A + + H+ RAQ + Y C G A Sbjct: 1575 PMP----AITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTA--- 1627 Query: 1524 PVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQP----- 1578 K+ + V+V P + G L ++ + + + +L L + + P Sbjct: 1628 ---------EKSFHVDVYVPPM--IEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWL 1676 Query: 1579 -QGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620 G P + + ++ +++I + + D+G+YIC A++V G Sbjct: 1677 KDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAG 1719 Score = 109 bits (272), Expect = 3e-23 Identities = 213/974 (21%), Positives = 351/974 (36%), Gaps = 134/974 (13%) Query: 715 PSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGVLWA------QGPLETVTLLPVARTD 768 P + LQ G + C+V P S+ RNGV + + + V +D Sbjct: 440 PGYYLQPG---QIPCSVDSLL---PFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSD 493 Query: 769 AALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLA 828 Y C ++ AG + V PP ++ + + G A+ C + S A Sbjct: 494 EGFYECIAVSSAGTGRAQ-TFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIIS------A 546 Query: 829 LFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTS 888 + + ++ R + A +L LE++ + D+G Y C ++ GSS S Sbjct: 547 VDYNLTWQRNDRDVRLAEPARIRTLA---NLSLELKSVKFNDAGEYHCMVSSEGGSSAAS 603 Query: 889 LFFQVRGAWVQVSPSPELQE---GQAVVLSCQVHTGVPEGTSYRWYRD-----GQPLQES 940 +F V+ +V+ P+ Q G V + C TG P+ D + + Sbjct: 604 VFLTVQEP-PKVTVMPKNQSFTGGSEVSIMCSA-TGYPKPKIAWTVNDMFIVGSHRYRMT 661 Query: 941 TSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRL 1000 + TL AG Y C A SA T ++ AP+ + + + + G + Sbjct: 662 SDGTLFIKNAAPKDAGIYGCLAS--NSAGTDKQNSTLRYIE-APKLMVVQSELLVALGDI 718 Query: 1001 GLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLE 1060 ++ C+ PP Q++ GD + P + + P L+I Sbjct: 719 TVMECKTSGIPPPQVKWFKGDLELR-------------PSTFLIIDPLLGLLKIQETQDL 765 Query: 1061 DEGVYICEASNTLGQASASADFDAQA--VNVQVWPGATVREGQLVNLTCLVWTTHPAQLT 1118 D G Y C A N G+A+ D + V +Q ++ G V L C V +P + T Sbjct: 766 DAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYV-QGYP-EPT 823 Query: 1119 YTWYQ-------------DGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPIT 1165 W + +L ++ + N+ D +Y C + +T Sbjct: 824 IKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVT 883 Query: 1166 LDVLYAPR-NLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTL 1224 + L AP + + G QL L + P + +L + +V + Sbjct: 884 VTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDG 943 Query: 1225 RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVP--EGAPITVTCA 1282 L + Q +D G Y+C A + G N + + + + I + + EG P+T+ C Sbjct: 944 SLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCK 1003 Query: 1283 DPAAHAPTLYTWYHNGRWLQEGPA-------ASLSFLVATRAHAGAYSCQAQDAQGTRSS 1335 P++ W G + A SL + +G Y C A + G + Sbjct: 1004 ASGNPKPSVI-WSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGY-AK 1061 Query: 1336 RPAALQVLYAPQDAVLSSFRDSRARSM-------------AVIQCTVDSEPPAELALSHD 1382 R L V P+ F D R S + C V S PP + + + Sbjct: 1062 RKVQLTVYVRPR-----VFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKE 1116 Query: 1383 GKVLATSSGVHS-LASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQ 1441 ++++ S H+ L SG+ + R + Y+C A N+ G+++ +L Sbjct: 1117 TQLISPFSPRHTFLPSGSMKITETRTS----------DSGMYLCVATNIAGNVTQAVKLN 1166 Query: 1442 VEGARVVAE--PGLDVPEGAALNLSCRLLGGPGPV-----GNSTFAWFWNDRRLH-AEPV 1493 V + L V G +++ C G P PV G ST D H + P Sbjct: 1167 VHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLV---DGEHHVSNPD 1223 Query: 1494 PTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPP-----KTPTMMVFVEPEGGL 1548 TL+ + AG+Y C+A G + + L V PP + P F E Sbjct: 1224 GTLSIDQATPSDAGIYTCVATNIAGTDETE-ITLHVQEPPTVEDLEPPYNTTFQERVANQ 1282 Query: 1549 RGILDCRVDSEPLASLT-LHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSD 1607 R C P ++ LH G L EP I +L L I ++ P D Sbjct: 1283 RIEFPCPAKGTPKPTIKWLHNGRELTGR--------EPGISILEDGTLLV--IASVTPYD 1332 Query: 1608 QGEYICSASNVLGS 1621 GEYIC A N G+ Sbjct: 1333 NGEYICVAVNEAGT 1346 Score = 103 bits (258), Expect = 1e-21 Identities = 194/875 (22%), Positives = 315/875 (36%), Gaps = 132/875 (15%) Query: 118 EISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTE---VDFNCSTPYVCLQEQV--- 171 ++ + ++ V + T + T+ P + G + + N ST C+ E V Sbjct: 3683 DLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTP 3742 Query: 172 RLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIH 231 R+ W+ + G H+++ H+ D GR L C + A + I Sbjct: 3743 RITWRKDGAVLAGNHARYSILENGFLHIQSAHVT----DTGRYL-CMATNAAGTDRRRID 3797 Query: 232 LQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQT------ 285 LQV P I P+ ++ TL C+ SI W K+G L Sbjct: 3798 LQVHVPPS---IAPGPTNMTVIVNVQTTLACEATGI--PKPSINWRKNGHLLNVDQNQNS 3852 Query: 286 ----KTGVLHLPQAAWSDAGVYTCQAENGVGS---LVSPPISLHIFMAEVQVSPAGPILE 338 +G L + + D Y C NG G V + + +A+ P ++ Sbjct: 3853 YRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIAD---EPTDFLVT 3909 Query: 339 NQTVTLVCNTPNEAPSDLRYSWYKNHV-LLEDAHSHTLRLH-----LATRAD-TGFYFCE 391 ++ T + P + W KN + LL + + LAT+ + G Y C Sbjct: 3910 KHAPAVITCTASGVPFPSIH-WTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCV 3968 Query: 392 VQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHI 451 +N GS V++ V+ PP+ + L +L C P + G I Sbjct: 3969 ARNAAGSAHRH-VTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEG-I 4026 Query: 452 LASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAA 511 +TSG +H+ SG L+I D+G Y C A N G A + + Sbjct: 4027 NVNTSG-RNHAVLPSGG-------LQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVP 4078 Query: 512 RLLISPAAEVVEG--QAVTLSCRSGLSPTPDARFSWYLNGALLHEG------PGSSLLLP 563 ++ E V + +TLSC + P PD +W+ +G + E SL + Sbjct: 4079 PVISPHLKEYVIAVDKPITLSCEADGLPPPD--ITWHKDGRAIVESIRQRVLSSGSLQIA 4136 Query: 564 AASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLL 623 DAG Y C A + A S+ LTV PPR + ++ + +L Sbjct: 4137 FVQPGDAGHYTCMA--ANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNE-----NSQAILP 4189 Query: 624 CRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEE 683 C D P + KD V+ +L K T P + + N +LE+ Sbjct: 4190 CVADGIPTPAINW-KKDNVLLANLLG--------------KYTAEP-YGELILENVVLED 4233 Query: 684 EGLYLCEASNALG--NASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSP-A 740 G Y C A+NA G + S T + T + +L +G + L+C +A G P Sbjct: 4234 SGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSC----KATGIPLP 4289 Query: 741 NFSW-FRNGVLWA-----QGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLY 794 +W F N ++ A G E V + V++ D+ Y C G + + Sbjct: 4290 KLTWTFNNNIIPAHFDSVNGHSELV-IERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEP 4348 Query: 795 PPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKA 854 P + + G A+ C V P + ++ K Sbjct: 4349 PVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTI---------------------QWNRKG 4387 Query: 855 EANSLKLEVRELGLG----------DSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSP 904 + +R+LG G D+G Y C ATN G S+ ++ + Sbjct: 4388 VDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPV 4447 Query: 905 E--LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL 937 E + G ++L+CQ TG P+ T W R G + Sbjct: 4448 ETVINAGGKIILNCQA-TGEPQPT-ITWSRQGHSI 4480 Score = 97.1 bits (240), Expect = 1e-19 Identities = 178/793 (22%), Positives = 286/793 (36%), Gaps = 127/793 (16%) Query: 901 SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDG------QPLQESTSATLRFAAITLTQ 954 +P LQ GQ + C V + +P S+ R+G Q L+ES S L A +TL+ Sbjct: 439 TPGYYLQPGQ---IPCSVDSLLPFTLSF--VRNGVTLGVDQYLKESASVNLDIAKVTLSD 493 Query: 955 AGAYHC---QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDP 1011 G Y C + G A T V P +VT+T PG +L C + S Sbjct: 494 EGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVT------PGERAVLTCLIISAV 547 Query: 1012 PAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASN 1071 L DR V R+ L LE+ D G Y C S+ Sbjct: 548 DYNLTWQRNDRDVRL---------AEPARIRTLA---NLSLELKSVKFNDAGEYHCMVSS 595 Query: 1072 TLGQASASADFDAQ-AVNVQVWP-GATVREGQLVNLTC---------LVWTTHPAQLT-- 1118 G ++AS Q V V P + G V++ C + WT + + Sbjct: 596 EGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGS 655 Query: 1119 --YTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLR 1176 Y DG ++ + N +DA Y C + + TL + AP+ + Sbjct: 656 HRYRMTSDG-------TLFIKNAAPKDAGIYGCLASNSAGTDKQNS--TLRYIEAPKLMV 706 Query: 1177 LTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTL-RLELRGPQPRD 1235 + L G + ++ C PP Q+ L ST + L L+++ Q D Sbjct: 707 VQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLD 766 Query: 1236 EGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE--GAPITVTCADPAAHAPTLYT 1293 G Y+C A + G+A + L + V + A V G+ +T+ C PT+ Sbjct: 767 AGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTI-K 825 Query: 1294 WYHNGRWLQEGPAASLSFLVAT---------------RAHAGAYSCQAQDAQG-TRSSRP 1337 W R L P S F V++ + G Y C+A++ G +S Sbjct: 826 W----RRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETT 881 Query: 1338 AALQVLYAPQDAVLSSFRDSRARSMAVIQCT-VDSEPPAELALSHDGKVLATSSGVHSLA 1396 + L AP + S + + CT + P E + +L + + + Sbjct: 882 VTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRS 941 Query: 1397 SGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV--AEPGLD 1454 G+ H++ R+Q+QD Y C A N+ G+ + + V + + L Sbjct: 942 DGSLHIE------RVQLQD----GGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILS 991 Query: 1455 VPEGAALNLSCRLLGGPGPVGNSTFAWFWNDR---------RLHAEPVPTLAFTHVARAQ 1505 EG + L C+ G P P + W+ + + A +L + Sbjct: 992 TIEGIPVTLPCKASGNPKP------SVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEE 1045 Query: 1506 AGMYHCLAELPTGAAASAPVMLRVLYPPK--------TPTMMVFVEPEGGLRGILDCRVD 1557 +G Y C A T A V L V P+ + V + G L C V Sbjct: 1046 SGEYVCTA-TNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVK 1104 Query: 1558 SEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASN 1617 S P +T ++L++ P+ H +++ I R SD G Y+C A+N Sbjct: 1105 SLPPPIITWAKETQLISPFSPR--------HTFLPSGSMK--ITETRTSDSGMYLCVATN 1154 Query: 1618 VLGSASTSTYFGV 1630 + G+ + + V Sbjct: 1155 IAGNVTQAVKLNV 1167 Score = 71.6 bits (174), Expect = 6e-12 Identities = 113/461 (24%), Positives = 163/461 (35%), Gaps = 44/461 (9%) Query: 1193 CTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSP--LGQA 1250 C+VDS P L+ G L ++ L++ DEGFY C A S G+A Sbjct: 451 CSVDSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRA 510 Query: 1251 NTSLELRLEGVRVILAP-EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAA-- 1307 T ++ E VI P V G +TC +A L TW N R ++ A Sbjct: 511 QTFFDVS-EPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNL-TWQRNDRDVRLAEPARI 568 Query: 1308 ------SLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARS 1361 SL AG Y C ++G S+ L V P+ V+ + S Sbjct: 569 RTLANLSLELKSVKFNDAGEYHCMV-SSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGS 627 Query: 1362 MAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD 1421 I C+ P ++A + + + S + GT ++ A P Sbjct: 628 EVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNA----------APKDAG 677 Query: 1422 TYVCTAQNLLGSISTIGRLQ-VEGAR-VVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTF 1479 Y C A N G+ L+ +E + +V + L V G + C+ G P P Sbjct: 678 IYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPP----QV 733 Query: 1480 AWFWNDRRLHAEPV----PTLAFTHVARAQ---AGMYHCLAELPTGAAASAPVMLRVLYP 1532 WF D L P L + Q AG Y C+A + A+ + L V P Sbjct: 734 KWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVA-INEAGRATGKITLDVGSP 792 Query: 1533 PKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLAS 1592 P V E G L C V P ++ + S+P + + A Sbjct: 793 PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGA- 851 Query: 1593 PNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRAL 1633 + I L SD+G YIC A N G + T V L Sbjct: 852 -----LFILNLWASDKGTYICEAENQFGKIQSETTVTVTGL 887 Score = 70.9 bits (172), Expect = 1e-11 Identities = 130/552 (23%), Positives = 212/552 (38%), Gaps = 85/552 (15%) Query: 1133 SIPLPNVTVRDATSYRC------GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGG 1186 ++ + VT+ D Y C G G +S P V+ P N+ +T G Sbjct: 483 NLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPP--VIQVPNNVTVT------PG 534 Query: 1187 QLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPN--TLRLELRGPQPRDEGFYSCSAR 1244 + A++ C + S L R + + A + L LEL+ + D G Y C Sbjct: 535 ERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVS 594 Query: 1245 SPLGQANTSLELRL-EGVRVILAPE-AAVPEGAPITVTCADPAAHAPTLYTWY------- 1295 S G + S+ L + E +V + P+ + G+ +++ C+ P + W Sbjct: 595 SEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKI-AWTVNDMFIV 653 Query: 1296 --HNGRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSS 1353 H R +G +L A AG Y C A ++ GT + + L+ + AP+ V+ S Sbjct: 654 GSHRYRMTSDG---TLFIKNAAPKDAGIYGCLASNSAGT-DKQNSTLRYIEAPKLMVVQS 709 Query: 1354 FRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQ- 1412 + V++C PP ++ L S+ + + L++Q Sbjct: 710 ELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLI--------IDPLLGLLKIQE 761 Query: 1413 VQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPE--GAALNLSCRLLGG 1470 QD+ AGD Y C A N G + L V V + DV G+ + L C + G Sbjct: 762 TQDLDAGD--YTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGY 819 Query: 1471 PGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQA---------------GMYHCLAEL 1515 P P T W RRL P+ + F+ + +Q G Y C AE Sbjct: 820 PEP----TIKW----RRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAEN 871 Query: 1516 PTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLA-SLTLHLGSRLVA 1574 G S T T+ V P G+ + ++ + L TL G+ + Sbjct: 872 QFGKIQSET----------TVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPE 921 Query: 1575 SSQPQGAPA---EPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631 + + P+I V + + + IE ++ D GEY C ASNV G+ + +T V Sbjct: 922 RRWIKNSAMLLQNPYITVRSDGS---LHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVH 978 Query: 1632 ALHRLHQFQQLL 1643 L + QQ+L Sbjct: 979 VLPTIQHGQQIL 990 Score = 58.2 bits (139), Expect = 7e-08 Identities = 98/425 (23%), Positives = 165/425 (38%), Gaps = 63/425 (14%) Query: 99 NLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDF 158 +L + +QP D+G Y ++ S T +TV PR+ + + E ++ Sbjct: 4132 SLQIAFVQPGDAGHYTC---MAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAIL 4188 Query: 159 NCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQ 218 C + + W+ + + EP G LE + + +D G C Sbjct: 4189 PCVADGI---PTPAINWKKDNVLLANLLGKYTAEPYGELILENVVL----EDSG-FYTC- 4239 Query: 219 LSVANHRAQSEIH---LQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIK 275 VAN+ A + H L V P ++ P ++ GE + L+C+ + + Sbjct: 4240 --VANNAAGEDTHTVSLTVHVLPTFTEL---PGDVSLNKGEQLRLSCKATGI--PLPKLT 4292 Query: 276 WLKDG----VRLQTKTG--VLHLPQAAWSDAGVYTCQAENGVGSLVS--------PPISL 321 W + + G L + + + D+G Y C AEN VG + + PP+ Sbjct: 4293 WTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPV-- 4350 Query: 322 HIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH------SHTL 375 F + + P+ N L C + ++ W + V +E +H + +L Sbjct: 4351 --FKGDYPSNWIEPLGGN--AILNCEVKGDPTPTIQ--WNRKGVDIEISHRIRQLGNGSL 4404 Query: 376 RLHLATRADTGFYFCEVQNVHGS-ERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCS 434 ++ D G Y C N G ERS +S+ + PP+ + AG IL+C Sbjct: 4405 AIYGTVNEDAGDYTCVATNEAGVVERS--MSLTLQSPPIITLEPVETVINAGGKIILNCQ 4462 Query: 435 VVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSAT 494 EP T+ S GH S S D D S S L I D ++ D+ E++C A Sbjct: 4463 ATGEPQPTITWSRQGH---SISWD-DRVNVLSNNS------LYIADAQKEDTSEFECVAR 4512 Query: 495 NSLGN 499 N +G+ Sbjct: 4513 NLMGS 4517 >gi|11225258 myelin associated glycoprotein isoform a precursor [Homo sapiens] Length = 626 Score = 143 bits (361), Expect = 1e-33 Identities = 111/422 (26%), Positives = 200/422 (47%), Gaps = 26/422 (6%) Query: 4 LPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYD- 62 LP ++ S G WG P + +G+C+ IPC F FP ++ P + +WY++ Sbjct: 7 LPLFWIMISASRGGH--WGAWMPSSISAFEGTCVSIPCRFDFPDELR-PAVVHGVWYFNS 63 Query: 63 -YSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISE 121 Y V + ++V F+GR+ +G+ R C LLL ++ PE G Y FR ++ Sbjct: 64 PYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGG 123 Query: 122 VNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPA 181 N+++ + +++ + P I P E++ GTEV+ +C P C + + L W G + Sbjct: 124 YNQYTFSEHSVLDIV---NTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180 Query: 182 RSVTFNSQKFEPTGVG-HLETLHMAMSWQDHGRILRCQLSVANHRAQSE--IHLQVKYAP 238 + E G + LH + + +G L CQ S N Q E + VKY P Sbjct: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240 Query: 239 KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ---TKTGVLHLPQA 295 V++ S + G V+L C +S+ P + + W++DG L+ ++ +L L + Sbjct: 241 VIVEM---NSSVEAIEGSHVSLLCGADSNPPPL--LTWMRDGTVLREAVAESLLLELEEV 295 Query: 296 AWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPI--LENQTVTLVCNTPNEAP 353 ++ GVY C AEN G + + L + A + + G + +E +TV+++C+T + P Sbjct: 296 TPAEDGVYACLAENAYGQ-DNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSN-P 353 Query: 354 SDLRYSWYKNHVLLEDAHSHTLRLHL--ATRADTGFYFCEVQNVHGSERSGPVSVVVNHP 411 + + + +L + L+L L + D G Y+C +N +G +R+ ++ V Sbjct: 354 DPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYG-QRATAFNLSVEFA 412 Query: 412 PL 413 P+ Sbjct: 413 PV 414 Score = 61.6 bits (148), Expect = 6e-09 Identities = 51/218 (23%), Positives = 89/218 (40%), Gaps = 18/218 (8%) Query: 328 VQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHL--ATRADT 385 V+++ + +E V+L+C + P L +W ++ +L +A + +L L L T A+ Sbjct: 243 VEMNSSVEAIEGSHVSLLCGADSNPPPLL--TWMRDGTVLREAVAESLLLELEEVTPAED 300 Query: 386 GFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVL 445 G Y C +N +G + V + V + P P + + G + CS S P L + Sbjct: 301 GVYACLAENAYGQDNR-TVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTI 359 Query: 446 SHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD 505 IL++ +S+ L+LE+ + D GEY C A N G + + Sbjct: 360 FKEKQILSTVIYESE-------------LQLELPAVSPEDDGEYWCVAENQYGQRATAFN 406 Query: 506 FHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARF 543 A +L+ + V C +P P F Sbjct: 407 LSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444 Score = 59.7 bits (143), Expect = 2e-08 Identities = 64/237 (27%), Positives = 99/237 (41%), Gaps = 34/237 (14%) Query: 1056 GAMLEDEGVYI-------------------CEAS--NTLGQASASADFDAQAVNVQVWPG 1094 G + EDEG ++ C+AS NT Q A D + V V Sbjct: 187 GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN 246 Query: 1095 ATVR--EGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS----IPLPNVTVRDATSYR 1148 ++V EG V+L C + P LT W +DG +A + + L VT + Y Sbjct: 247 SSVEAIEGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGVYA 304 Query: 1149 CGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHA 1208 C + +R + L V+YAP + + + G+ +LC+ S P L + Sbjct: 305 CLA--ENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKE 362 Query: 1209 GRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265 ++L++ S L+LEL P D+G Y C A + GQ T+ L +E V+L Sbjct: 363 KQILSTVIYES---ELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416 Score = 59.3 bits (142), Expect = 3e-08 Identities = 95/388 (24%), Positives = 150/388 (38%), Gaps = 59/388 (15%) Query: 1298 GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRP-AALQVLYAPQDAVLSSFRD 1356 G W+Q + L F+ A+ CQA T A++ V Y P ++S + Sbjct: 194 GTWVQ---VSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250 Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416 + S + C DS PP L DG VL + +L L++++V Sbjct: 251 AIEGSHVSLLCGADSNPPPLLTWMRDGTVLR---------------EAVAESLLLELEEV 295 Query: 1417 -PAGDDTYVCTAQNLLGSISTIGRLQVEGA--RVVAEPGLDVPEGAALNLSCRLLGGPGP 1473 PA D Y C A+N G + L V A + + EG +++ C P P Sbjct: 296 TPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDP 355 Query: 1474 VGNSTFAWFWNDRRLHA----EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRV 1529 + + ++++ + E L V+ G Y C+AE G A+A L V Sbjct: 356 I-----LTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATA-FNLSV 409 Query: 1530 LYPPKTPTMMVFVEPEGGLRGILDCR--VDSEPLASLTLHLGSR--LVASSQPQGAPAEP 1585 + P +++ R + C V S P S+ L SR V S+ + +E Sbjct: 410 EFAP----VLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSER 465 Query: 1586 HIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWV 1645 VL S LR +A IC+A N+ G+ S F + HR L+W Sbjct: 466 SGLVLTSILTLRGQAQA-----PPRVICTARNLYGAKSLELPF--QGAHR------LMWA 512 Query: 1646 ----LGLLVGLLLLLLGLGACYTWRRRR 1669 +G +V +L+ + CY + RR Sbjct: 513 KIGPVGAVVAFAILIAIV--CYITQTRR 538 Score = 58.9 bits (141), Expect = 4e-08 Identities = 58/249 (23%), Positives = 98/249 (39%), Gaps = 22/249 (8%) Query: 721 EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLL--PVARTDAALYACRILT 778 EG+ +L C + P +W R+G + + E++ L V + +YAC + Sbjct: 253 EGSHVSLLCGAD---SNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYAC-LAE 308 Query: 779 EAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLAT 838 A Q + V LSV+Y P +P ++ + +G +C+ S P +L +F + +L+T Sbjct: 309 NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILST 368 Query: 839 SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV 898 + + L+LE+ + D G Y C A N G T+ V A V Sbjct: 369 VI--------------YESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414 Query: 899 QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATL--RFAAITLTQAG 956 + S V C V + ++ + ES + + + LT Sbjct: 415 LLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSIL 474 Query: 957 AYHCQAQAP 965 QAQAP Sbjct: 475 TLRGQAQAP 483 Score = 57.4 bits (137), Expect = 1e-07 Identities = 58/249 (23%), Positives = 95/249 (38%), Gaps = 37/249 (14%) Query: 898 VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST--SATLRFAAITLTQA 955 V+++ S E EG V L C + P + W RDG L+E+ S L +T + Sbjct: 243 VEMNSSVEAIEGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAED 300 Query: 956 GAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQL 1015 G Y C A+ +A + L V YAP T+ M G +LC S+P L Sbjct: 301 GVYACLAE---NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPIL 357 Query: 1016 RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQ 1075 + +++++ + + L+LE+ ED+G Y C A N GQ Sbjct: 358 TIFKEKQILSTVIY-----------------ESELQLELPAVSPEDDGEYWCVAENQYGQ 400 Query: 1076 ASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIP 1135 + + + + V + V C+V + + A +P Sbjct: 401 RATAFNLSVEFAPVLLLESHCAAARDTVQCLCVV-------------KSNPEPSVAFELP 447 Query: 1136 LPNVTVRDA 1144 NVTV ++ Sbjct: 448 SRNVTVNES 456 Score = 55.1 bits (131), Expect = 6e-07 Identities = 52/228 (22%), Positives = 90/228 (39%), Gaps = 31/228 (13%) Query: 515 ISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDA--GS 572 ++ + E +EG V+L C + +P P +W +G +L E SLLL T A G Sbjct: 245 MNSSVEAIEGSHVSLLCGADSNPPP--LLTWMRDGTVLREAVAESLLLELEEVTPAEDGV 302 Query: 573 YHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPA 632 Y C A + + + L+V+Y P +PT + A G +LC S+P Sbjct: 303 YACLAENAYGQD--NRTVGLSVMYAPWKPTVNGTM-----VAVEGETVSILCSTQSNPDP 355 Query: 633 RLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEAS 692 L + + ++++T + + L++E+ E++G Y C A Sbjct: 356 ILTIFKEKQILSTVI--------------------YESELQLELPAVSPEDDGEYWCVAE 395 Query: 693 NALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740 N G +T+ + + + + SH C V S A Sbjct: 396 NQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVA 443 Score = 54.3 bits (129), Expect = 1e-06 Identities = 95/398 (23%), Positives = 144/398 (36%), Gaps = 70/398 (17%) Query: 904 PELQEGQAVVLSCQVHTGVPE-GTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYH--- 959 PE+ G V +SC V PE W + + LR T Q H Sbjct: 147 PEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVP 206 Query: 960 ----------CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDS 1009 CQA P + T S+ V Y P V + + ++ G LLC DS Sbjct: 207 TREANGHRLGCQASFPNT-TLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADS 265 Query: 1010 DPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA 1069 +PP L + +G+ R VA +L LE+ ++GVY C A Sbjct: 266 NPPPLLTWMR---------------DGTVLREAVA---ESLLLELEEVTPAEDGVYACLA 307 Query: 1070 SNTLGQASASADFDAQAVNVQVWPGATV--REGQLVNLTC--------LVWTTHPAQLTY 1119 N GQ + + + T+ EG+ V++ C ++ Q+ Sbjct: 308 ENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILS 367 Query: 1120 TWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY 1179 T + + +L+ LP V+ D Y C + + + L V +AP Sbjct: 368 TVIYESELQLE-----LPAVSPEDDGEYWCVA--ENQYGQRATAFNLSVEFAP-----VL 415 Query: 1180 LLESH---GGQLALVLCTVDSRPPAQLA---------LSHAGRLLASSTAASVPNTLRLE 1227 LLESH LC V S P +A ++ + R S + + T L Sbjct: 416 LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILT 475 Query: 1228 LRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265 LRG Q + C+AR+ G SLEL +G ++ Sbjct: 476 LRG-QAQAPPRVICTARNLYGA--KSLELPFQGAHRLM 510 Score = 47.8 bits (112), Expect = 9e-05 Identities = 44/182 (24%), Positives = 71/182 (39%), Gaps = 19/182 (10%) Query: 402 GPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDH 461 G S+ V +PP+ + + +E G L C S P L G +L + Sbjct: 230 GYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAE--- 286 Query: 462 SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAA--RLLISPAA 519 SL LE+ ++ + G Y C A N+ G T+ A + ++ Sbjct: 287 -----------SLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTM 335 Query: 520 EVVEGQAVTLSCRSGLSPTPDARF--SWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRA 577 VEG+ V++ C + +P P + +++E L LPA S D G Y C A Sbjct: 336 VAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE-LQLELPAVSPEDDGEYWCVA 394 Query: 578 RD 579 + Sbjct: 395 EN 396 Score = 45.8 bits (107), Expect = 4e-04 Identities = 63/282 (22%), Positives = 100/282 (35%), Gaps = 39/282 (13%) Query: 722 GTEANLTCNV--------------SREAAGSPANFSWFRNGV-LWAQGPLETVTLLPVAR 766 GTE ++C V E G PA R W Q L + +P Sbjct: 152 GTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSL--LHFVPTRE 209 Query: 767 TDAALYACRI-LTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLA 825 + C+ Q + V YPP ++++ ++ +G +C DS P Sbjct: 210 ANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPP 269 Query: 826 LLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSS 885 LL G +A A SL LE+ E+ + G Y C A N G Sbjct: 270 LLTWMR---------------DGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD 314 Query: 886 NTSLFFQVRGA-W-VQVSPSPELQEGQAVVLSCQVHTGV-PEGTSYRWYRDGQPLQESTS 942 N ++ V A W V+ + EG+ V + C + P T ++ + + + Sbjct: 315 NRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE 374 Query: 943 ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAP 984 L A++ G Y C A+ + A +L V +AP Sbjct: 375 LQLELPAVSPEDDGEYWCVAE---NQYGQRATAFNLSVEFAP 413 >gi|18104957 myelin associated glycoprotein isoform b precursor [Homo sapiens] Length = 582 Score = 143 bits (361), Expect = 1e-33 Identities = 111/422 (26%), Positives = 200/422 (47%), Gaps = 26/422 (6%) Query: 4 LPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYD- 62 LP ++ S G WG P + +G+C+ IPC F FP ++ P + +WY++ Sbjct: 7 LPLFWIMISASRGGH--WGAWMPSSISAFEGTCVSIPCRFDFPDELR-PAVVHGVWYFNS 63 Query: 63 -YSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISE 121 Y V + ++V F+GR+ +G+ R C LLL ++ PE G Y FR ++ Sbjct: 64 PYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGG 123 Query: 122 VNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPA 181 N+++ + +++ + P I P E++ GTEV+ +C P C + + L W G + Sbjct: 124 YNQYTFSEHSVLDIV---NTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180 Query: 182 RSVTFNSQKFEPTGVG-HLETLHMAMSWQDHGRILRCQLSVANHRAQSE--IHLQVKYAP 238 + E G + LH + + +G L CQ S N Q E + VKY P Sbjct: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240 Query: 239 KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ---TKTGVLHLPQA 295 V++ S + G V+L C +S+ P + + W++DG L+ ++ +L L + Sbjct: 241 VIVEM---NSSVEAIEGSHVSLLCGADSNPPPL--LTWMRDGTVLREAVAESLLLELEEV 295 Query: 296 AWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPI--LENQTVTLVCNTPNEAP 353 ++ GVY C AEN G + + L + A + + G + +E +TV+++C+T + P Sbjct: 296 TPAEDGVYACLAENAYGQ-DNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSN-P 353 Query: 354 SDLRYSWYKNHVLLEDAHSHTLRLHL--ATRADTGFYFCEVQNVHGSERSGPVSVVVNHP 411 + + + +L + L+L L + D G Y+C +N +G +R+ ++ V Sbjct: 354 DPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYG-QRATAFNLSVEFA 412 Query: 412 PL 413 P+ Sbjct: 413 PV 414 Score = 61.6 bits (148), Expect = 6e-09 Identities = 51/218 (23%), Positives = 89/218 (40%), Gaps = 18/218 (8%) Query: 328 VQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHL--ATRADT 385 V+++ + +E V+L+C + P L +W ++ +L +A + +L L L T A+ Sbjct: 243 VEMNSSVEAIEGSHVSLLCGADSNPPPLL--TWMRDGTVLREAVAESLLLELEEVTPAED 300 Query: 386 GFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVL 445 G Y C +N +G + V + V + P P + + G + CS S P L + Sbjct: 301 GVYACLAENAYGQDNR-TVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTI 359 Query: 446 SHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD 505 IL++ +S+ L+LE+ + D GEY C A N G + + Sbjct: 360 FKEKQILSTVIYESE-------------LQLELPAVSPEDDGEYWCVAENQYGQRATAFN 406 Query: 506 FHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARF 543 A +L+ + V C +P P F Sbjct: 407 LSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444 Score = 59.7 bits (143), Expect = 2e-08 Identities = 64/237 (27%), Positives = 99/237 (41%), Gaps = 34/237 (14%) Query: 1056 GAMLEDEGVYI-------------------CEAS--NTLGQASASADFDAQAVNVQVWPG 1094 G + EDEG ++ C+AS NT Q A D + V V Sbjct: 187 GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN 246 Query: 1095 ATVR--EGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS----IPLPNVTVRDATSYR 1148 ++V EG V+L C + P LT W +DG +A + + L VT + Y Sbjct: 247 SSVEAIEGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGVYA 304 Query: 1149 CGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHA 1208 C + +R + L V+YAP + + + G+ +LC+ S P L + Sbjct: 305 CLA--ENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKE 362 Query: 1209 GRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265 ++L++ S L+LEL P D+G Y C A + GQ T+ L +E V+L Sbjct: 363 KQILSTVIYES---ELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416 Score = 59.3 bits (142), Expect = 3e-08 Identities = 95/388 (24%), Positives = 150/388 (38%), Gaps = 59/388 (15%) Query: 1298 GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRP-AALQVLYAPQDAVLSSFRD 1356 G W+Q + L F+ A+ CQA T A++ V Y P ++S + Sbjct: 194 GTWVQ---VSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250 Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416 + S + C DS PP L DG VL + +L L++++V Sbjct: 251 AIEGSHVSLLCGADSNPPPLLTWMRDGTVLR---------------EAVAESLLLELEEV 295 Query: 1417 -PAGDDTYVCTAQNLLGSISTIGRLQVEGA--RVVAEPGLDVPEGAALNLSCRLLGGPGP 1473 PA D Y C A+N G + L V A + + EG +++ C P P Sbjct: 296 TPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDP 355 Query: 1474 VGNSTFAWFWNDRRLHA----EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRV 1529 + + ++++ + E L V+ G Y C+AE G A+A L V Sbjct: 356 I-----LTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATA-FNLSV 409 Query: 1530 LYPPKTPTMMVFVEPEGGLRGILDCR--VDSEPLASLTLHLGSR--LVASSQPQGAPAEP 1585 + P +++ R + C V S P S+ L SR V S+ + +E Sbjct: 410 EFAP----VLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSER 465 Query: 1586 HIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWV 1645 VL S LR +A IC+A N+ G+ S F + HR L+W Sbjct: 466 SGLVLTSILTLRGQAQA-----PPRVICTARNLYGAKSLELPF--QGAHR------LMWA 512 Query: 1646 ----LGLLVGLLLLLLGLGACYTWRRRR 1669 +G +V +L+ + CY + RR Sbjct: 513 KIGPVGAVVAFAILIAIV--CYITQTRR 538 Score = 58.9 bits (141), Expect = 4e-08 Identities = 58/249 (23%), Positives = 98/249 (39%), Gaps = 22/249 (8%) Query: 721 EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLL--PVARTDAALYACRILT 778 EG+ +L C + P +W R+G + + E++ L V + +YAC + Sbjct: 253 EGSHVSLLCGAD---SNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYAC-LAE 308 Query: 779 EAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLAT 838 A Q + V LSV+Y P +P ++ + +G +C+ S P +L +F + +L+T Sbjct: 309 NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILST 368 Query: 839 SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV 898 + + L+LE+ + D G Y C A N G T+ V A V Sbjct: 369 VI--------------YESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414 Query: 899 QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATL--RFAAITLTQAG 956 + S V C V + ++ + ES + + + LT Sbjct: 415 LLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSIL 474 Query: 957 AYHCQAQAP 965 QAQAP Sbjct: 475 TLRGQAQAP 483 Score = 57.4 bits (137), Expect = 1e-07 Identities = 58/249 (23%), Positives = 95/249 (38%), Gaps = 37/249 (14%) Query: 898 VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST--SATLRFAAITLTQA 955 V+++ S E EG V L C + P + W RDG L+E+ S L +T + Sbjct: 243 VEMNSSVEAIEGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAED 300 Query: 956 GAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQL 1015 G Y C A+ +A + L V YAP T+ M G +LC S+P L Sbjct: 301 GVYACLAE---NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPIL 357 Query: 1016 RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQ 1075 + +++++ + + L+LE+ ED+G Y C A N GQ Sbjct: 358 TIFKEKQILSTVIY-----------------ESELQLELPAVSPEDDGEYWCVAENQYGQ 400 Query: 1076 ASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIP 1135 + + + + V + V C+V + + A +P Sbjct: 401 RATAFNLSVEFAPVLLLESHCAAARDTVQCLCVV-------------KSNPEPSVAFELP 447 Query: 1136 LPNVTVRDA 1144 NVTV ++ Sbjct: 448 SRNVTVNES 456 Score = 55.1 bits (131), Expect = 6e-07 Identities = 52/228 (22%), Positives = 90/228 (39%), Gaps = 31/228 (13%) Query: 515 ISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDA--GS 572 ++ + E +EG V+L C + +P P +W +G +L E SLLL T A G Sbjct: 245 MNSSVEAIEGSHVSLLCGADSNPPP--LLTWMRDGTVLREAVAESLLLELEEVTPAEDGV 302 Query: 573 YHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPA 632 Y C A + + + L+V+Y P +PT + A G +LC S+P Sbjct: 303 YACLAENAYGQD--NRTVGLSVMYAPWKPTVNGTM-----VAVEGETVSILCSTQSNPDP 355 Query: 633 RLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEAS 692 L + + ++++T + + L++E+ E++G Y C A Sbjct: 356 ILTIFKEKQILSTVI--------------------YESELQLELPAVSPEDDGEYWCVAE 395 Query: 693 NALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740 N G +T+ + + + + SH C V S A Sbjct: 396 NQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVA 443 Score = 54.3 bits (129), Expect = 1e-06 Identities = 95/398 (23%), Positives = 144/398 (36%), Gaps = 70/398 (17%) Query: 904 PELQEGQAVVLSCQVHTGVPE-GTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYH--- 959 PE+ G V +SC V PE W + + LR T Q H Sbjct: 147 PEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVP 206 Query: 960 ----------CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDS 1009 CQA P + T S+ V Y P V + + ++ G LLC DS Sbjct: 207 TREANGHRLGCQASFPNT-TLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADS 265 Query: 1010 DPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA 1069 +PP L + +G+ R VA +L LE+ ++GVY C A Sbjct: 266 NPPPLLTWMR---------------DGTVLREAVA---ESLLLELEEVTPAEDGVYACLA 307 Query: 1070 SNTLGQASASADFDAQAVNVQVWPGATV--REGQLVNLTC--------LVWTTHPAQLTY 1119 N GQ + + + T+ EG+ V++ C ++ Q+ Sbjct: 308 ENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILS 367 Query: 1120 TWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY 1179 T + + +L+ LP V+ D Y C + + + L V +AP Sbjct: 368 TVIYESELQLE-----LPAVSPEDDGEYWCVA--ENQYGQRATAFNLSVEFAP-----VL 415 Query: 1180 LLESH---GGQLALVLCTVDSRPPAQLA---------LSHAGRLLASSTAASVPNTLRLE 1227 LLESH LC V S P +A ++ + R S + + T L Sbjct: 416 LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILT 475 Query: 1228 LRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265 LRG Q + C+AR+ G SLEL +G ++ Sbjct: 476 LRG-QAQAPPRVICTARNLYGA--KSLELPFQGAHRLM 510 Score = 47.8 bits (112), Expect = 9e-05 Identities = 44/182 (24%), Positives = 71/182 (39%), Gaps = 19/182 (10%) Query: 402 GPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDH 461 G S+ V +PP+ + + +E G L C S P L G +L + Sbjct: 230 GYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAE--- 286 Query: 462 SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAA--RLLISPAA 519 SL LE+ ++ + G Y C A N+ G T+ A + ++ Sbjct: 287 -----------SLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTM 335 Query: 520 EVVEGQAVTLSCRSGLSPTPDARF--SWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRA 577 VEG+ V++ C + +P P + +++E L LPA S D G Y C A Sbjct: 336 VAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE-LQLELPAVSPEDDGEYWCVA 394 Query: 578 RD 579 + Sbjct: 395 EN 396 Score = 45.8 bits (107), Expect = 4e-04 Identities = 63/282 (22%), Positives = 100/282 (35%), Gaps = 39/282 (13%) Query: 722 GTEANLTCNV--------------SREAAGSPANFSWFRNGV-LWAQGPLETVTLLPVAR 766 GTE ++C V E G PA R W Q L + +P Sbjct: 152 GTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSL--LHFVPTRE 209 Query: 767 TDAALYACRI-LTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLA 825 + C+ Q + V YPP ++++ ++ +G +C DS P Sbjct: 210 ANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPP 269 Query: 826 LLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSS 885 LL G +A A SL LE+ E+ + G Y C A N G Sbjct: 270 LLTWMR---------------DGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD 314 Query: 886 NTSLFFQVRGA-W-VQVSPSPELQEGQAVVLSCQVHTGV-PEGTSYRWYRDGQPLQESTS 942 N ++ V A W V+ + EG+ V + C + P T ++ + + + Sbjct: 315 NRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE 374 Query: 943 ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAP 984 L A++ G Y C A+ + A +L V +AP Sbjct: 375 LQLELPAVSPEDDGEYWCVAE---NQYGQRATAFNLSVEFAP 413 >gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] Length = 1215 Score = 134 bits (338), Expect = 6e-31 Identities = 180/727 (24%), Positives = 267/727 (36%), Gaps = 97/727 (13%) Query: 855 EANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPE--LQEGQAV 912 E+ + E+ + G+Y C A + G+ V Q+ P+P + G+ Sbjct: 358 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETA 417 Query: 913 VLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITL-------TQAGAYHCQAQAP 965 VLSC+V P + W RD + L ST + A ++L T G Y C A Sbjct: 418 VLSCRVLGEAPYNLT--WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA 475 Query: 966 GSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVA 1025 T A + L V AP+ T+ G + C P + + + Sbjct: 476 NGVT---RASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ 532 Query: 1026 STLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF--- 1082 R+HV L I G ED G Y C+A+N +G + Sbjct: 533 -----------EDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 578 Query: 1083 ---DAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL------DAHS 1133 AVN V V G+ L C P ++ WY+ G + + + Sbjct: 579 DPPSVSAVNAVV----LVAVGEEAVLVCEASGVPPPRV--IWYRGGLEMILAPEGSSSGK 632 Query: 1134 IPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVL 1192 + +P RDA +Y C V G A S I L V +AP+ L + G+ AL+ Sbjct: 633 LRIPAAQERDAGTYTCRAVNELGDA---SAEIQLAVGHAPQLTELPRDVTVELGRSALLA 689 Query: 1193 CTVDSRPPAQLALSHAG------RLLASSTAAS-VPNTLRLELRGPQPRDEGFYSCSARS 1245 C RPP + RL A + S P++ L P D+ Y C AR+ Sbjct: 690 CRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 749 Query: 1246 PLGQANTSLELRLEGVR----VILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWL 1301 G+ L + G AP V EG P+++ C A W +GR L Sbjct: 750 VFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPL 809 Query: 1302 QEGPA------ASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR 1355 G SL A + HAG YSC A + G++ R L V P+ ++ Sbjct: 810 PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQ-HRDVELVVQVPPRIHPTATHH 868 Query: 1356 DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQD 1415 + A + C P + + + L TS G H S G + +A+ + QD Sbjct: 869 ITNEGVPASLPCVASGVPAPTITWTKETNAL-TSRGPHYNVSKEGTLLIAQPS----AQD 923 Query: 1416 VPAGDDTYVCTAQNLLG--------SISTIGRLQVEGARVVAEP-GLDVPEGAALNLSCR 1466 A YVCTA N +G S++T R+ + G+R P + G + L C Sbjct: 924 AGA----YVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCE 979 Query: 1467 LLGGPGPVGNSTFAWFWNDR-------RLHAEPVPTLAFTHVARAQAGMYHCLAELPTGA 1519 G P P+ W + R R P +L V +G Y C A P G+ Sbjct: 980 AKGSPPPL----VTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGS 1035 Query: 1520 AASAPVM 1526 A+ V+ Sbjct: 1036 ASHRYVL 1042 Score = 127 bits (319), Expect = 9e-29 Identities = 173/702 (24%), Positives = 253/702 (36%), Gaps = 83/702 (11%) Query: 683 EEGLYLCEASN--ALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740 EEG Y C A + G A L AP+ T+ G A L+C V EA P Sbjct: 373 EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA---PY 429 Query: 741 NFSWFRNGVLWAQGPLETVTLLPVAR----------TDAALYACRILTEAGAQLSTPVLL 790 N +W R+ W P T + +A TD Y C + + A V L Sbjct: 430 NLTWVRD---WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQC-VASNANGVTRASVWL 485 Query: 791 SVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRF 850 V P ++ QG C+ P H+ + + R Sbjct: 486 LVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTP--------HISWSRESQALQEDSRI 537 Query: 851 QAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN--TSLFFQVRGAWVQVSPSPELQE 908 A+ L ++ + D+G+Y C+ATN +G+ +L++ + V+ + Sbjct: 538 HVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAV 594 Query: 909 GQAVVLSCQVHTGVPEGTSYRWYRDGQPL----QESTSATLRFAAITLTQAGAYHCQAQA 964 G+ VL C+ +GVP WYR G + + S+S LR A AG Y C+A Sbjct: 595 GEEAVLVCEA-SGVPPPRVI-WYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAV- 651 Query: 965 PGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLV 1024 + +A I L V +AP+ L + GR LL CR PP + GD Sbjct: 652 --NELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQP 709 Query: 1025 ASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF-- 1082 G G GS R P++ L ED+ Y+CEA N G+ A A Sbjct: 710 LGLRLGAG--RGSRSR-----QPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762 Query: 1083 --DAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ---------RLDA 1131 A P V EGQ V+L C+V P + W +DG+ R D Sbjct: 763 TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH-WLKDGRPLPPGSRHSIRADG 821 Query: 1132 HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPR-NLRLTYLLESHGGQLAL 1190 S+ L A Y C A R + L V PR + T+ + + G +L Sbjct: 822 -SLHLDRALQEHAGRYSCVA--TNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASL 878 Query: 1191 VLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLG-- 1248 P L + +V L + P +D G Y C+A + +G Sbjct: 879 PCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFS 938 Query: 1249 ------QANTSLELRLEGVRVILAP-EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWL 1301 NT + + G R P + G +T+ C + P L TW + R + Sbjct: 939 SQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDC-EAKGSPPPLVTWTKDSRPV 997 Query: 1302 QE-------GPAASLSFLVATRAHAGAYSCQAQDAQGTRSSR 1336 P+ SL +G Y C A + G+ S R Sbjct: 998 PPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHR 1039 Score = 112 bits (279), Expect = 4e-24 Identities = 164/667 (24%), Positives = 246/667 (36%), Gaps = 72/667 (10%) Query: 1002 LLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061 L+ C V S P +L+L G+ + H + N+ EI A + Sbjct: 328 LVSCSVHSALPFRLQLRRGEARLGE-------------ERHFQESGNS-SWEILRASKAE 373 Query: 1062 EGVYICEASNTLGQASASADFDAQAVNVQVWPG--ATVREGQLVNLTCLVWTTHPAQLTY 1119 EG Y C A + G A A Q+ P TV G+ L+C V P LT Sbjct: 374 EGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT- 432 Query: 1120 TWYQDGQ---------QRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLY 1170 W +D + +L S+ + + D Y+C R S + L V Sbjct: 433 -WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS--VWLLVRE 489 Query: 1171 APRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRG 1230 AP+ T G V C+ P ++ S + L + V L ++G Sbjct: 490 APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQG 549 Query: 1231 PQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAA--VPEGAPITVTCADPAAHA 1288 P D G YSC A + +G ++ L + A A V G + C + + Sbjct: 550 VAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC-EASGVP 608 Query: 1289 PTLYTWYHNGRWLQEGPAAS----LSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLY 1344 P WY G + P S L A AG Y+C+A + G S+ L V + Sbjct: 609 PPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE-IQLAVGH 667 Query: 1345 APQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSH-DGKVLATSSGVHSLASGTGHVQ 1403 APQ L A++ C PP + DG+ L L +G G Sbjct: 668 APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL-----RLGAGRGSRS 722 Query: 1404 VARNALRLQVQDV-PAGDDTYVCTAQNLLGSISTIGRLQVEGAR----VVAEPGLDVPEG 1458 ++ L + V P YVC A+N+ G + RL V G + P + V EG Sbjct: 723 RQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEG 782 Query: 1459 AALNLSCRLLGG-PGPVGNSTFAWFWNDRRL---HAEPVPTLAFTHVARA---QAGMYHC 1511 ++L C +L G P P + W + R L + H+ RA AG Y C Sbjct: 783 QPVSLPCIVLAGRPLPERH----WLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSC 838 Query: 1512 LAELPTGAAASAPVMLRVLYPPKT-PTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGS 1570 +A T + V L V PP+ PT + E G+ L C P ++T + Sbjct: 839 VA-TNTAGSQHRDVELVVQVPPRIHPTATHHITNE-GVPASLPCVASGVPAPTITWTKET 896 Query: 1571 RLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGV 1630 + S P ++ ++A P+A D G Y+C+A+N +G +S V Sbjct: 897 NALTSRGPHYNVSKEGTLLIAQPSA----------QDAGAYVCTATNTVGFSSQEMRLSV 946 Query: 1631 RALHRLH 1637 R+H Sbjct: 947 NTKPRIH 953 Score = 107 bits (267), Expect = 1e-22 Identities = 166/625 (26%), Positives = 229/625 (36%), Gaps = 105/625 (16%) Query: 210 DHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYP 269 D GR +C S AN ++ + L V+ AP+ + + S ++ G V ++C S YP Sbjct: 464 DGGRY-QCVASNANGVTRASVWLLVREAPQ---VSIHTSSQHFSQGVEVKVSCSA-SGYP 518 Query: 270 AVSSIKWLKDGVRLQTKT-------GVLHLPQAAWSDAGVYTCQAENGVGS-------LV 315 I W ++ LQ + G L + A DAG Y+CQA N VG+ Sbjct: 519 T-PHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY 577 Query: 316 SPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLL----EDAH 371 + P S+ A V V+ + LVC P R WY+ + + E + Sbjct: 578 TDPPSVSAVNAVVLVAVG------EEAVLVCEASGVPPP--RVIWYRGGLEMILAPEGSS 629 Query: 372 SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGIL 431 S LR+ A D G Y C N G + S + + V H P L + + G +L Sbjct: 630 SGKLRIPAAQERDAGTYTCRAVNELG-DASAEIQLAVGHAPQLTELPRDVTVELGRSALL 688 Query: 432 HCSVVSEPLATLVLSHG-GHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYK 490 C P T+ G G L G + R S + P+S L + D Y Sbjct: 689 ACRATGRPPPTVTWRRGDGQPLGLRLG----AGRGSRSRQPDSGVLFFESVAPEDQAPYV 744 Query: 491 CSATNSLGN----ATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWY 546 C A N G A + HA +P V+EGQ V+L C L+ P W Sbjct: 745 CEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIV-LAGRPLPERHWL 803 Query: 547 LNGALLHEGP------GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPR- 599 +G L G SL L A AG Y C A + +A L V PPR Sbjct: 804 KDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATN--TAGSQHRDVELVVQVPPRI 861 Query: 600 QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGC 659 PT T + + A L C V S PA K+ TS Sbjct: 862 HPTATHHITNEGVPAS------LPC-VASGVPAPTITWTKETNALTSR------------ 902 Query: 660 SPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG----------NASTSATFNGQAT 709 P V+K LL I P ++ G Y+C A+N +G N NG Sbjct: 903 GPHYNVSKEGTLL---IAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRN 959 Query: 710 VLAIAPSHTLQEGTEANLTCNVSREAAGSPANF-SWF-----------RNGVLWAQGPLE 757 + T + G E L C EA GSP +W R G+L P Sbjct: 960 A-NVPLQVTAKAGEEVTLDC----EAKGSPPPLVTWTKDSRPVPPITNRYGLL----PSG 1010 Query: 758 TVTLLPVARTDAALYACRILTEAGA 782 ++ L V D+ Y C AG+ Sbjct: 1011 SLRLAQVQVGDSGHYECTASNPAGS 1035 Score = 105 bits (263), Expect = 3e-22 Identities = 182/747 (24%), Positives = 279/747 (37%), Gaps = 97/747 (12%) Query: 761 LLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVD 820 +L ++ + Y C ++ AG + ++ V PP + + + + G A+ C V Sbjct: 366 ILRASKAEEGTYECTAVSRAGTGRAKAQIV-VTDPPPQLVPAPNVTVSPGETAVLSCRVL 424 Query: 821 SRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATN 880 L +L S G A+ L LE+ + D G Y+C A+N Sbjct: 425 GEAPYNLTWVRDWRVLPASTG----------RVAQLADLSLEISGIIPTDGGRYQCVASN 474 Query: 881 VLGSSNTSLFFQVRGAWVQVS---PSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL 937 G + S++ VR A QVS S +G V +SC +G P W R+ Q L Sbjct: 475 ANGVTRASVWLLVREA-PQVSIHTSSQHFSQGVEVKVSCSA-SGYPT-PHISWSRESQAL 531 Query: 938 QEST------SATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTT 991 QE + TL + AG Y CQA + + ++L+ + P + Sbjct: 532 QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQAT---NEVGTDQETVTLYYTDPPSVSAVNA 588 Query: 992 LMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLR 1051 ++ G +L+C PP ++ G L+ + PEGSS + Sbjct: 589 VVLVAVGEEAVLVCEASGVPPPRVIWYRGG------LEMILAPEGSSSG----------K 632 Query: 1052 LEIHGAMLEDEGVYICEASNTLGQASASADFDA-QAVNVQVWP-GATVREGQLVNLTCLV 1109 L I A D G Y C A N LG ASA A + P TV G+ L C Sbjct: 633 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRA 692 Query: 1110 WTTHPAQLTYTWYQ-DGQ--------------QRLDAHSIPLPNVTVRDATSYRCGVGPP 1154 P T TW + DGQ ++ D+ + +V D Y C Sbjct: 693 TGRPPP--TVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNV 750 Query: 1155 -GRAPRLSRPITLDVLYAPRNLRLTY----LLESHGGQLALVLCTVDSRPPAQLALSHAG 1209 G+ +R I +AP + + +LE G ++L + RP + G Sbjct: 751 FGKVQAEARLIVTG--HAPPQIASSAPTVRVLE--GQPVSLPCIVLAGRPLPERHWLKDG 806 Query: 1210 RLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEA 1269 R L + S+ L L G YSC A + G + +EL ++ V + P A Sbjct: 807 RPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ-VPPRIHPTA 865 Query: 1270 A---VPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLS----FLVA--TRAHAG 1320 EG P ++ C APT+ GP ++S L+A + AG Sbjct: 866 THHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAG 925 Query: 1321 AYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR-------DSRARSMAVIQCTVDSEP 1373 AY C A + G SS+ L V P+ + S ++A + C P Sbjct: 926 AYVCTATNTVGF-SSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSP 984 Query: 1374 PAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGS 1433 P + + D + + + + L +G +++A QVQ +G Y CTA N GS Sbjct: 985 PPLVTWTKDSRPVPPITNRYGLLP-SGSLRLA------QVQVGDSGH--YECTASNPAGS 1035 Query: 1434 ISTIGRLQVEGARVVAEPGLDVPEGAA 1460 S L V+G L VP A Sbjct: 1036 ASHRYVLGVQGRTSWQPQSLPVPHHPA 1062 Score = 96.7 bits (239), Expect = 2e-19 Identities = 173/738 (23%), Positives = 260/738 (35%), Gaps = 109/738 (14%) Query: 380 ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEP 439 A++A+ G Y C + G+ R+ +VV PP V + G +L C V+ E Sbjct: 369 ASKAEEGTYECTAVSRAGTGRA-KAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA 427 Query: 440 LATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG- 498 L +L +++G + L LEI + TD G Y+C A+N+ G Sbjct: 428 PYNLTWVRDWRVLPASTG---------RVAQLADLSLEISGIIPTDGGRYQCVASNANGV 478 Query: 499 NATSTLDFHANAARLLISPAAE-VVEGQAVTLSCRSGLSPTPDARFSWYLNGALL----- 552 S A ++ I +++ +G V +SC + PTP SW L Sbjct: 479 TRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTP--HISWSRESQALQEDSR 536 Query: 553 -HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDA 611 H +L++ + DAG+Y C+A + G V P + + L A Sbjct: 537 IHVDAQGTLIIQGVAPEDAGNYSCQAT---NEVGTDQETVTLYYTDPPSVSAVNAVVLVA 593 Query: 612 AGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNL 671 G A +L+C PP R+ + ++ + P G S ++++ A Sbjct: 594 VGEEA----VLVCEASGVPPPRV-IWYRGGLEMILAPEGSS-------SGKLRIPAAQE- 640 Query: 672 LRVEIHNPLLEEEGLYLCEASNALGNASTSATFN-GQATVLAIAPSH-TLQEGTEANLTC 729 + G Y C A N LG+AS G A L P T++ G A L C Sbjct: 641 ----------RDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLAC 690 Query: 730 NVSREAAGSPANFSWFR-------------NGVLWAQGPLETVTLLPVARTDAALYACRI 776 R P +W R G Q + VA D A Y C Sbjct: 691 ---RATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEA 747 Query: 777 LTEAG-AQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTV-DSRPLALLALFHGEH 834 G Q ++++ PP + + + +G C V RPL H Sbjct: 748 RNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLP------ERH 801 Query: 835 LLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSS--NTSLFFQ 892 L G +P R +A+ + L + +G Y C ATN GS + L Q Sbjct: 802 WLKD--GRPLPPGSRHSIRADGS---LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ 856 Query: 893 VRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRD-------GQPLQESTSATL 945 V + EG L C V +GVP T W ++ G S TL Sbjct: 857 VPPRIHPTATHHITNEGVPASLPC-VASGVPAPT-ITWTKETNALTSRGPHYNVSKEGTL 914 Query: 946 RFAAITLTQAGAYHCQA-QAPGSATTSLAAPIS----LHVSYAPRHVTLTTLMDTGPGRL 1000 A + AGAY C A G ++ + ++ +H++ R+ + + G Sbjct: 915 LIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMN-GSRNANVPLQVTAKAGEE 973 Query: 1001 GLLLCRVDSDPPAQLRLLHGDRLVASTLQGVG-GPEGSSPRLHVAVAPNTLRLEIHGAML 1059 L C PP + R V G P GS L + + Sbjct: 974 VTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGS--------------LRLAQVQV 1019 Query: 1060 EDEGVYICEASNTLGQAS 1077 D G Y C ASN G AS Sbjct: 1020 GDSGHYECTASNPAGSAS 1037 Score = 90.9 bits (224), Expect = 1e-17 Identities = 185/796 (23%), Positives = 281/796 (35%), Gaps = 150/796 (18%) Query: 252 ILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTG--------VLHLPQAAWSDAGVY 303 + PGE L+C+V P ++ W++D L TG L + +D G Y Sbjct: 411 VSPGETAVLSCRVLGEAPY--NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRY 468 Query: 304 TCQAENGVGSL---------VSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPS 354 C A N G +P +S+H + + + V + C+ Sbjct: 469 QCVASNANGVTRASVWLLVREAPQVSIH--------TSSQHFSQGVEVKVSCSASGYPTP 520 Query: 355 DLRYSWYKNHVLLEDAHSH-----TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVN 409 + +S ++ L ED+ H TL + D G Y C+ N G+++ V++ Sbjct: 521 HISWS-RESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQE-TVTLYYT 578 Query: 410 HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGG--HILASTSGDSDHSPRFSG 467 PP + A + G +L C P ++ GG ILA Sbjct: 579 DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP------------- 625 Query: 468 TSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFH-ANAARLLISPAAEVVE-GQ 525 G +S +L I +E D+G Y C A N LG+A++ + +A +L P VE G+ Sbjct: 626 -EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGR 684 Query: 526 AVTLSCRSGLSPTPDA---RFSWYLNGALLHEGPGSS--------LLLPAASSTDAGSYH 574 + L+CR+ P P R G L G GS L + + D Y Sbjct: 685 SALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYV 744 Query: 575 CRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARL 634 C AR+ + ++T PP+ + G+ L C V + P Sbjct: 745 CEARNVFGKVQAEARLIVTGHAPPQIAS-----SAPTVRVLEGQPVSLPCIVLAGRPLPE 799 Query: 635 QLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNA 694 + KD LP G S S + + L E G Y C A+N Sbjct: 800 RHWLKD---GRPLPPGSRHSIRADGS-------------LHLDRALQEHAGRYSCVATNT 843 Query: 695 LGNASTSATFNGQA--TVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFR-NGVL 750 G+ Q + A H EG A+L C A+G PA +W + L Sbjct: 844 AGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPC----VASGVPAPTITWTKETNAL 899 Query: 751 WAQGPLETV----TLL---PVARTDAALYACRILTEAGAQLSTPVLLSVLYPP------- 796 ++GP V TLL P A+ DA Y C G S + LSV P Sbjct: 900 TSRGPHYNVSKEGTLLIAQPSAQ-DAGAYVCTATNTVGFS-SQEMRLSVNTKPRIHMNGS 957 Query: 797 DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEA 856 + + G C P L+ P P R+ Sbjct: 958 RNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSR-------PVPPITNRYGLLPSG 1010 Query: 857 NSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRG--AWVQVSPSPELQEGQAVVL 914 + L + ++ +GDSG Y C A+N GS++ V+G +W Q L Sbjct: 1011 S---LRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSW------------QPQSL 1055 Query: 915 SCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQ------AGAYHCQAQAPGSA 968 H G S PL + T ++R ++L A C +QA S+ Sbjct: 1056 PVPHHPACLSGLSV-------PLLQPTPRSVRLCHLSLRAPLPPPFATPTSCLSQACLSS 1108 Query: 969 TTSLAAPISLHVSYAP 984 +T +SLH+S P Sbjct: 1109 ST-----LSLHLSPYP 1119 Score = 89.4 bits (220), Expect = 3e-17 Identities = 171/772 (22%), Positives = 273/772 (35%), Gaps = 101/772 (13%) Query: 910 QAVVLSCQVHTGVPEGTSYRWYR----DGQPLQESTSATLRFAAITLTQAGAYHCQAQAP 965 Q +++SC VH+ +P R + + QES +++ + + G Y C A + Sbjct: 325 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSR 384 Query: 966 GSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVA 1025 + A + V+ P + + PG +L CRV + P L + R++ Sbjct: 385 AGTGRAKAQIV---VTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL- 440 Query: 1026 STLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF--- 1082 P + +A L LEI G + D G Y C ASN G AS Sbjct: 441 --------PASTGRVAQLA----DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR 488 Query: 1083 DAQAVNVQVWPGATVREGQLVNLTC---------LVWTTHPAQLTYTWYQDGQQRLDAH- 1132 +A V++ +G V ++C + W+ L +D + +DA Sbjct: 489 EAPQVSIHT-SSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ----EDSRIHVDAQG 543 Query: 1133 SIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVL 1192 ++ + V DA +Y C +TL P + ++ G+ A+++ Sbjct: 544 TLIIQGVAPEDAGNYSCQA--TNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 601 Query: 1193 CTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANT 1252 C PP ++ G + + S LR+ Q RD G Y+C A + LG A+ Sbjct: 602 CEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIP--AAQERDAGTYTCRAVNELGDASA 659 Query: 1253 SLELRLEGVRVI--LAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN------------- 1297 ++L + + L + V G + C PT+ TW Sbjct: 660 EIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTV-TWRRGDGQPLGLRLGAGR 718 Query: 1298 GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSS--FR 1355 G ++ + L F Y C+A++ G + + +AP S+ R Sbjct: 719 GSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVR 778 Query: 1356 DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQD 1415 + +++ + P E DG+ L S A G+ H+ A LQ Sbjct: 779 VLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRA-----LQEH- 832 Query: 1416 VPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLD--VPEGAALNLSCRLLGGPGP 1473 AG Y C A N GS L V+ + EG +L C G P P Sbjct: 833 --AG--RYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP 888 Query: 1474 VGNSTFAWFWNDRRL-------HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVM 1526 T W L + TL + AG Y C A G + S + Sbjct: 889 ----TITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFS-SQEMR 943 Query: 1527 LRVLYPPK-------TPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQ 1579 L V P+ + + V + G LDC P +T SR V Sbjct: 944 LSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPV------ 997 Query: 1580 GAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631 P + + L +LR + ++ D G Y C+ASN GSAS GV+ Sbjct: 998 --PPITNRYGLLPSGSLR--LAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045 Score = 85.1 bits (209), Expect = 5e-16 Identities = 128/523 (24%), Positives = 198/523 (37%), Gaps = 83/523 (15%) Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159 L+++ + PED+G+Y+ + +EV +D + + T+ P V + + V + G E Sbjct: 545 LIIQGVAPEDAGNYSCQ-ATNEVG--TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 601 Query: 160 CSTPYVCLQEQVRLQWQGQDPARSVTFNS---QKFEPTGVGHLETLHMAMSWQDHGRILR 216 C G P R + + P G + A +D G Sbjct: 602 CEA-------------SGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYT- 647 Query: 217 CQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW 276 C+ A +EI L V +AP+ ++ P + G L C+ P ++ W Sbjct: 648 CRAVNELGDASAEIQLAVGHAPQLTEL---PRDVTVELGRSALLACRATGRPPP--TVTW 702 Query: 277 LKD-----GVRL---------QTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLH 322 + G+RL Q +GVL A D Y C+A N G + + + Sbjct: 703 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762 Query: 323 IFMAEVQVSPAGP---ILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLR--- 376 A Q++ + P +LE Q V+L C P R+ W K+ L H++R Sbjct: 763 TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH-WLKDGRPLPPGSRHSIRADG 821 Query: 377 -LHL--ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHC 433 LHL A + G Y C N GS+ VV P + P T + T G+ L C Sbjct: 822 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHI-TNEGVPASLPC 880 Query: 434 SVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSA 493 P T+ + + L TS ++ GT L I D+G Y C+A Sbjct: 881 VASGVPAPTITWTKETNAL--TSRGPHYNVSKEGT-------LLIAQPSAQDAGAYVCTA 931 Query: 494 TNSLGNATSTL--------DFHANAARLLISPAAEVVE-GQAVTLSCRSGLSPTPDARFS 544 TN++G ++ + H N +R P + G+ VTL C + SP P + Sbjct: 932 TNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPP--LVT 989 Query: 545 WYLNG----------ALLHEGPGSSLLLPAASSTDAGSYHCRA 577 W + LL P SL L D+G Y C A Sbjct: 990 WTKDSRPVPPITNRYGLL---PSGSLRLAQVQVGDSGHYECTA 1029 Score = 47.8 bits (112), Expect = 9e-05 Identities = 78/315 (24%), Positives = 118/315 (37%), Gaps = 52/315 (16%) Query: 217 CQLSVANHRAQSEIHLQVK-YAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIK 275 C+ + Q+E L V +AP +I S +L G+ V+L C V + P + Sbjct: 745 CEARNVFGKVQAEARLIVTGHAPP--QIASSAPTVRVLEGQPVSLPCIVLAGRP-LPERH 801 Query: 276 WLKDGVRLQTKT-------GVLHLPQAAWSDAGVYTCQAENGVGS-------LVSPPISL 321 WLKDG L + G LHL +A AG Y+C A N GS +V P + Sbjct: 802 WLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI 861 Query: 322 HIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH-----TLR 376 H + P +L C + ++ N + H + TL Sbjct: 862 HPTATHHITNEGVP------ASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLL 915 Query: 377 LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPV-------LTAFLETQAGLVG 429 + + D G Y C N G S + + VN P + + + +AG Sbjct: 916 IAQPSAQDAGAYVCTATNTVGFS-SQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEV 974 Query: 430 ILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSG---PNSLRLEIRDLEETDS 486 L C P L + + DS P + G SLRL ++ DS Sbjct: 975 TLDCEAKGSPPP----------LVTWTKDSRPVPPITNRYGLLPSGSLRL--AQVQVGDS 1022 Query: 487 GEYKCSATNSLGNAT 501 G Y+C+A+N G+A+ Sbjct: 1023 GHYECTASNPAGSAS 1037 Score = 40.4 bits (93), Expect = 0.015 Identities = 87/393 (22%), Positives = 136/393 (34%), Gaps = 60/393 (15%) Query: 40 PCIFSFPADVEVPDGITAIWYYDYSGQRQ--VVSHSADPKLVEARF-RGRTEFMGNPEHR 96 P + P DV V G +A+ +G+ V D + + R GR P+ Sbjct: 669 PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG 728 Query: 97 VCNLLLKDLQPEDSGSYNFRFEISEV-NRWSDVKGT---LVTVTEEPRVPTIASPVELLE 152 V L + + PED Y + E N + V+ +VT P++ + A V +LE Sbjct: 729 V--LFFESVAPEDQAPY-----VCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLE 781 Query: 153 GTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHL----ETLHMAMSW 208 G V C + G+ + P G H +LH+ + Sbjct: 782 GQPVSLPC------------IVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRAL 829 Query: 209 QDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSY 268 Q+H C + ++ L V+ P+ + P+ + + E V + +S Sbjct: 830 QEHAGRYSCVATNTAGSQHRDVELVVQVPPR-----IHPTATHHITNEGVPASLPCVASG 884 Query: 269 PAVSSIKWLKDGVRLQT--------KTGVLHLPQAAWSDAGVYTCQAENGVG-------- 312 +I W K+ L + K G L + Q + DAG Y C A N VG Sbjct: 885 VPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRL 944 Query: 313 SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLED--- 369 S+ + P V + VTL C P +W K+ + Sbjct: 945 SVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPP--LVTWTKDSRPVPPITN 1002 Query: 370 ----AHSHTLRLHLATRADTGFYFCEVQNVHGS 398 S +LRL D+G Y C N GS Sbjct: 1003 RYGLLPSGSLRLAQVQVGDSGHYECTASNPAGS 1035 >gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF isoform a [Homo sapiens] Length = 6620 Score = 119 bits (297), Expect = 3e-26 Identities = 374/1644 (22%), Positives = 572/1644 (34%), Gaps = 315/1644 (19%) Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159 L++ D+ PED+G Y E V V +T+ + +E+LEG F Sbjct: 2703 LVVHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKT------MEVLEGESCSFE 2756 Query: 160 CSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHM-AMSWQDHGRILRCQ 218 C + + G+ +S +F+ T G L + + D G ++ Sbjct: 2757 CVLSHESASDPAMWTVGGK-----TVGSSSRFQATRQGRKYILVVREAAPSDAGEVV--- 2808 Query: 219 LSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLK 278 SV S+ L V+ P I+ + + PGE V L C+++ A + + WLK Sbjct: 2809 FSVRG--LTSKASLIVRERP--AAIIKPLEDQWVAPGEDVELRCELSR---AGTPVHWLK 2861 Query: 279 D--GVRLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHI----- 323 D +R K V L + A+ DAG YTC+ E + SLH+ Sbjct: 2862 DRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKST-----ASLHVEEKAN 2916 Query: 324 ----FMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH------ 373 + +QV G T C T + A + +W K + L + H Sbjct: 2917 CFTEELTNLQVEEKG------TAVFTCKTEHPAAT---VTWRKGLLELRASGKHQPSQEG 2967 Query: 374 -TLRLHLAT--RADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGI 430 TLRL ++ +AD+ Y C++ G +S +V ++ Q G Sbjct: 2968 LTLRLTISALEKADSDTYTCDI----GQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSAT 3023 Query: 431 LHCSVVS---EPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487 C + EP+ + H A+ + D P G + L L R L DSG Sbjct: 3024 FRCRISPANYEPVHWFLDKTPLH--ANELNEIDAQP-----GGYHVLTL--RQLALKDSG 3074 Query: 488 EYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYL 547 A + +A + + ++ A + EG+ +TL C + T D W Sbjct: 3075 TIYFEAGDQRASAALRVTEKPSVFSRELTDAT-ITEGEDLTLVCETS---TCDIPVCWTK 3130 Query: 548 NGALL---------HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598 +G L HEG + LL+ A+ D+G Y C A G S +++ V Sbjct: 3131 DGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKC------EAGGACSSSIVRV--HA 3182 Query: 599 RQPTFTTRL-DLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCG 657 R F L DL+ GA L C V S A ++ + + V+ Sbjct: 3183 RPVRFQEALKDLEVLEGGA---ATLRC-VLSSVAAPVKWCYGNNVLRP------------ 3226 Query: 658 GCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNG---QATVLAIA 714 + + + +L + + N ++ G Y C + G+ +TSAT A + Sbjct: 3227 --GDKYSLRQEGAMLELVVRNLRPQDSGRYSC----SFGDQTTSATLTVTALPAQFIGKL 3280 Query: 715 PSHTLQEGTEANLTCNVSREAAGSPANFS-WFRNG---VLWAQGPLETVTLLPVARTDAA 770 + EG A L C +S+ A S R+G L G + + + +A DAA Sbjct: 3281 RNKEATEGATATLRCELSKAAPVEWRKGSETLRDGDRYCLRQDGAMCELQIRGLAMVDAA 3340 Query: 771 LYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALF 830 Y+C G + ++ L P + +G A C + A + Sbjct: 3341 EYSC----VCGEERTSASLTIRPMPAHFIGRLRHQESIEGATATLRCELSK--AAPVEWR 3394 Query: 831 HGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLF 890 G L R + + +L++ L + D+G Y C V G TS Sbjct: 3395 KGRESLRDG--------DRHSLRQDGAVCELQICGLAVADAGEYSC----VCGEERTSAT 3442 Query: 891 FQVR---GAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRW------YRDGQPL---Q 938 V+ + + + E EG +L C++ P W RDG Q Sbjct: 3443 LTVKALPAKFTEGLRNEEAVEGATAMLWCELSKVAP----VEWRKGPENLRDGDRYILRQ 3498 Query: 939 ESTSATLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP 997 E T L+ + + AG Y C Q SAT ++ A R + + Sbjct: 3499 EGTRCELQICGLAMADAGEYLCVCGQERTSATLTIRA-------LPARFIEDVKNQEARE 3551 Query: 998 GRLGLLLCRVDSDPPAQLR-----LLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRL 1052 G +L C ++S P + R L GDR +L+ G L Sbjct: 3552 GATAVLQCELNSAAPVEWRKGSETLRDGDRY---SLRQDG---------------TKCEL 3593 Query: 1053 EIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG---ATVREGQLVNLTCLV 1109 +I G + D G Y C GQ SA +A+ ++ G EG L C + Sbjct: 3594 QIRGLAMADTGEYSC----VCGQERTSAMLTVRALPIKFTEGLRNEEATEGATAVLRCEL 3649 Query: 1110 WTTHPAQLTYTWYQDGQQRL---DAHS---------IPLPNVTVRDATSYRCGVGPPGRA 1157 P + W++ G + L D HS + + + DA Y C G + Sbjct: 3650 SKMAPVE----WWK-GHETLRDGDRHSLRQDGARCELQIRGLVAEDAGEYLCMCGKERTS 3704 Query: 1158 PRLS-RPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASST 1216 L+ R + + RN E+ G A + C + P + H L Sbjct: 3705 AMLTVRAMPSKFIEGLRN------EEATEGDTATLWCELSKAAPVEWRKGH--ETLRDGD 3756 Query: 1217 AASV---PNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEA---A 1270 S+ + L++RG D G YSC GQ TS L + + + Sbjct: 3757 RHSLRQDGSRCELQIRGLAVVDAGEYSCVC----GQERTSATLTVRALPARFIEDVKNQE 3812 Query: 1271 VPEGAPITVTC----ADPAAHAPTLYTWYHNGRW--LQEGPAASLSFLVATRAHAGAYSC 1324 EGA + C A P T R+ Q+G L + A G YSC Sbjct: 3813 AREGATAVLQCELSKAAPVEWRKGSETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSC 3872 Query: 1325 QAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHD 1382 R +A + APQ + +A S A +QC + SEP A Sbjct: 3873 VC------GQERTSATLTVRAPQPVFREPLQSLQAEEGSTATLQCEL-SEPTA------- 3918 Query: 1383 GKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQ 1441 V+ + G+ A+G ++ L +QD+ D Y CT GS +T L Sbjct: 3919 -TVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTC----GSQATSATLT 3973 Query: 1442 VEGARVVAEPGL---DVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP------ 1492 V A V L +V EG +L C L V W L P Sbjct: 3974 VTAAPVRFLRELQHQEVDEGGTAHLCCELSRAGASVE-------WRKGSLQLFPCAKYQM 4026 Query: 1493 -----VPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGG 1547 L V + AG Y C TG S + + PK T + +E E G Sbjct: 4027 VQDGAAAELLVRGVEQEDAGDYTC----DTGHTQSMASLSVRVPRPKFKTRLQSLEQETG 4082 Query: 1548 LRGILDCRV-DSEPLA-------SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVD 1599 L C++ D+E A + LH G + S QGA E IH Sbjct: 4083 DIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRS--QGATRELLIH----------- 4129 Query: 1600 IEALRPSDQGEYICSASNVLGSAS 1623 L D GEY C +AS Sbjct: 4130 --QLEAKDTGEYACVTGGQKTAAS 4151 Score = 108 bits (269), Expect = 6e-23 Identities = 242/1165 (20%), Positives = 397/1165 (34%), Gaps = 237/1165 (20%) Query: 255 GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYT 304 G L+C+V A + + W KDG +L + + V L LPQA +DAG Y+ Sbjct: 1089 GASAMLSCEVAQ---AQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYS 1145 Query: 305 CQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTV---------TLVCNTPNEAPSD 355 C+A +S H+ + E P G + Q+V T + A Sbjct: 1146 CEAG-------GQRVSFHLHITE----PKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQ 1194 Query: 356 LRYSWYKNHVLLEDAHSHTLRLHLATR---------ADTGFYFCEVQNVHGSER---SGP 403 +WYK+ L + + + TR AD G Y CE S + + P Sbjct: 1195 TEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEP 1254 Query: 404 VSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP 463 +V ++ + T+AG L C V G + +S+ Sbjct: 1255 KAVFAKE----QLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSS-------- 1302 Query: 464 RFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN--------AARLLI 515 + + +L ++ + D+GEY C A L FH + A L Sbjct: 1303 KVRIEAAGCMRQLVVQQAGQADAGEYTCEA------GGQRLSFHLDVSEPKAVFAKEQLA 1356 Query: 516 SPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHE---------GPGSSLLLPAAS 566 + G TLSC + T +WY +G L G L++ A Sbjct: 1357 HRKVQAEAGAIATLSCEVAQAQT---EVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQAC 1413 Query: 567 STDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRV 626 D G Y C A G S A V++ QP A AG L C V Sbjct: 1414 QADTGEYSCEA-GGQRLSFSLDVAEPKVVFAKEQPVHR------EVQAQAGASTTLSCEV 1466 Query: 627 DSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGL 686 A+ +++ S S GC+ R+ V +A + G Sbjct: 1467 ---AQAQTEVMWYKDGKKLSFSSKVRMEAV-GCTRRLVVQQAGQAV-----------AGE 1511 Query: 687 YLCEASNA-----LGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPAN 741 Y CEA + L A A F A + + GT A L+C E A + Sbjct: 1512 YSCEAGSQRLSFHLHVAEPKAVF---AKEQPASREVQAEAGTSATLSC----EVAQAQTE 1564 Query: 742 FSWFRNGV---------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQ-------LS 785 +W+++G + A G + + + DA Y+C+ AG Q ++ Sbjct: 1565 VTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCK----AGDQRLSFHLHVA 1620 Query: 786 TPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVP 845 P ++ P ++ A G A C V + G+ L ++S Sbjct: 1621 EPKVVFAKEQPAHREVQA----EAGASATLSCEVAQAQTEVTWYKDGKKLSSSS------ 1670 Query: 846 SHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSP- 904 + + +A + +L V++ G D+G Y CEA G S V Q+S P Sbjct: 1671 ---KVRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQRLSFRLHVAELEPQISERPC 1723 Query: 905 -----ELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQES---------TSATLRFAAI 950 ++E + ++L+ + T P + W +DG ++ S + TL Sbjct: 1724 RREPLVVKEHEDIILTATLAT--PSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGA 1781 Query: 951 TLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSD 1010 + + Y C+ A G V L++ G LG + Sbjct: 1782 QVLDSAIYSCRVGAEGQ---------DFPVQVEEVAAKFCRLLEPVCGELGGTVTLACEL 1832 Query: 1011 PPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLR-LEIHGAMLEDEGVYICEA 1069 PA A + G + + VA +R L + G ED G Y+CE+ Sbjct: 1833 SPA----------CAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCES 1882 Query: 1070 SNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDG---- 1125 + A + + EG C+V P+ + W++DG Sbjct: 1883 RDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVV---SPSDVAVVWFRDGALLQ 1939 Query: 1126 -------QQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLT 1178 Q +HS+ + ++ + DA A S L V AP + Sbjct: 1940 PSEKFAISQSGASHSLTISDLVLEDAGQITV------EAEGASSSAALRVREAPVLFKKK 1993 Query: 1179 YLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPR---- 1234 ++ + ++ L +RP +L R ++TA + + + G + R Sbjct: 1994 LEPQTVEERSSVTLEVELTRPWPEL------RWTRNATALAPGKNVEIHAEGARHRLVLH 2047 Query: 1235 -----DEGFYSCSARSPLGQANTSLELR----LEGVRVILAPEAAVPEGAPITVTCADPA 1285 D GF+ C QA ++E+R + G++ + A E T T Sbjct: 2048 NVGFADRGFFGCETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQG-------TATMEVQL 2100 Query: 1286 AHAPTLYTWYHNGRWLQEGPAASLS 1310 +HA +W +G Q+GP L+ Sbjct: 2101 SHADVDGSWTRDGLRFQQGPTCHLA 2125 Score = 107 bits (268), Expect = 8e-23 Identities = 282/1306 (21%), Positives = 449/1306 (34%), Gaps = 223/1306 (17%) Query: 441 ATLVLSHGGHILASTSGDSDHSP-----RFSGTSGPNSLRLEIRDLEETDSGEYKCSATN 495 ATL G+ S + D P RF + RL I DL DSG+Y C A N Sbjct: 27 ATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARN 86 Query: 496 SLGNATSTLDFHANAAR---------LLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWY 546 ++G A + + +A LL + V EG T CR G SP P SW Sbjct: 87 AIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRP--AVSWS 144 Query: 547 LNGALLHE-----------GPGSSLLLPAASSTDAGSYHCRAR--------------DGH 581 +G L E G S+L + AA D G+Y RA D Sbjct: 145 KDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSD 204 Query: 582 SASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDR 641 +A S P T + + A A G C V ARL Sbjct: 205 AADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGE 264 Query: 642 VVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTS 701 ++ G G + N + ++I + GLY C ASN +G +S Sbjct: 265 PKPETVWKKDGQLVTEGRRHVVYEDAQENFV-LKILFCKQSDRGLYTCTASNLVGQTYSS 323 Query: 702 ATFNGQATVLAI---APSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV-LWA----- 752 + + ++E A C V + + + +WF+ LWA Sbjct: 324 VLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPSTEA----AWFKEETRLWASAKYG 379 Query: 753 ---QGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQ 809 +G +T+ V+ D A+Y C T G++ + + P+ +A + Sbjct: 380 IEEEGTERRLTVRNVSADDDAVYICE--TPEGSRTVAELAVQGNLLRKLPRKTA---VRV 434 Query: 810 GHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869 G A+F C + P+ + + +V + GR AE L + + L Sbjct: 435 GDTAMF-CVELAVPVGPVHWLRNQE--------EVVAGGRVAISAEGTRHTLTISQCCLE 485 Query: 870 DSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGV------- 922 D G + + G TS F V P LQ V+ ++ + V Sbjct: 486 DVG----QVAFMAGDCQTSTQF-----CVSAPRKPPLQPPVDPVVKARMESSVILSWSPP 536 Query: 923 PEGT----------------SYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPG 966 P G +Y W R + AT + + G + + A Sbjct: 537 PHGERPVTIDGYLVEKKKLGTYTWIRCH---EAEWVATPELTVADVAEEGNFQFRVSALN 593 Query: 967 SATTS--LAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVD-SDPPAQLRLLHGDRL 1023 S S L P ++H+ AP+ T L G + VD + A L G L Sbjct: 594 SFGQSPYLEFPGTVHL--APKLAVRTPLKAVQAVEGGEVTFSVDLTVASAGEWFLDGQAL 651 Query: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFD 1083 AS++ E R + + +HGA L+ ++ + + A Sbjct: 652 KASSVY-----EIHCDRTRHTLTIREVPASLHGAQLK----FVANGIESSIRMEVRA--- 699 Query: 1084 AQAVNVQVWPGATVRE--GQLVNLTCLVWTTHPAQLTYTWYQDG-----------QQRLD 1130 A + P A RE +L L+ TW +DG Q Sbjct: 700 APGLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAG 759 Query: 1131 AHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVL--YAPRNLRLTYLLESHGGQL 1188 + + +V DA Y C R R++ +++ L + +++ + + GG Sbjct: 760 RRVLLVRDVARDDAGLYEC----VSRGGRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPA 815 Query: 1189 ALVLCTVDSRPPAQ-----LALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSA 1243 T ++ + L H+G V RL +DEG YSC Sbjct: 816 QFECETSEAHVHVHWYKDGMELGHSGERFLQE---DVGTRHRLVAATVTRQDEGTYSCR- 871 Query: 1244 RSPLGQANTSLELRLEGVRVILAPE------AAVPEGAPITVTCADPAAHAPTLYTWYHN 1297 +G+ + LR+ +V+ A E GA T++C A A T TWY + Sbjct: 872 ---VGEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSC--EVAQAQTEVTWYKD 926 Query: 1298 GRWLQEGPAASLSFLVATR---------AHAGAYSCQAQDAQGTRSSRPAALQVLYAPQD 1348 G+ L + TR A AG YSC+A + + +V++A +D Sbjct: 927 GKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFA-KD 985 Query: 1349 AVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNA 1408 V S + A + A + C V ++ E+ DGK L++S VH A G R Sbjct: 986 QVAHSEVQAEAGASATLSCEV-AQAQTEVMWYKDGKKLSSSLKVHVEAKG-----CRRRL 1039 Query: 1409 LRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV------AEPGLDVPEGAALN 1462 + Q AGD Y C A+ S RL + +++ + GA+ Sbjct: 1040 VVQQAGKTDAGD--YSCEARGQRVSF----RLHITEPKMMFAKEQSVHNEVQAEAGASAM 1093 Query: 1463 LSCRLLGGPGPVGNSTFAWFWNDRRLHAEP---------VPTLAFTHVARAQAGMYHCLA 1513 LSC + V W+ + ++L + L +A AG Y C A Sbjct: 1094 LSCEVAQAQTEV-----TWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEA 1148 Query: 1514 ELPTGAAASAPVMLRVLYP----PKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLG 1569 L + P K ++ V+ E G +L C V ++P +T + Sbjct: 1149 -----GGQRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEV-AQPQTEVTWYKD 1202 Query: 1570 SRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSA 1615 + ++SS + + R+ ++ + +D GEY C A Sbjct: 1203 GKKLSSSS--------KVRMEVKGCTRRLVVQQVGKADAGEYSCEA 1240 Score = 106 bits (264), Expect = 2e-22 Identities = 312/1484 (21%), Positives = 520/1484 (35%), Gaps = 255/1484 (17%) Query: 256 ELVTLTCQVNSSYPAVSSIKWLKDGVRL--QTKTGV--------LHLPQAAWSDAGVYTC 305 E T C+V P+ + W K+ RL K G+ L + + D VY C Sbjct: 348 ESATFLCEVPQ--PSTEAA-WFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYIC 404 Query: 306 QAENGVGSLVSPPISLHI-----------------FMAEVQVSPAGPI--LENQTVTLVC 346 + G ++ + ++ F E+ V P GP+ L NQ + Sbjct: 405 ETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAV-PVGPVHWLRNQEEVVAG 463 Query: 347 NTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSV 406 + R++ + LED +A T FC + R P+ Sbjct: 464 GRVAISAEGTRHTLTISQCCLEDVGQVAF---MAGDCQTSTQFCV-----SAPRKPPLQ- 514 Query: 407 VVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466 PP+ PV+ A +E+ L S P ++ G+++ + R Sbjct: 515 ----PPVDPVVKARMESSVIL------SWSPPPHGERPVTIDGYLVEKKKLGTYTWIRCH 564 Query: 467 GTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN---AARLLISP---AAE 520 + L + D+ E + +++ SA NS G + L+F A +L + A + Sbjct: 565 EAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPY-LEFPGTVHLAPKLAVRTPLKAVQ 623 Query: 521 VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDG 580 VEG VT S + T + W+L+G L ++ HC R Sbjct: 624 AVEGGEVTFS----VDLTVASAGEWFLDGQAL-------------KASSVYEIHCD-RTR 665 Query: 581 HSASGPSSPAVL---TVLYPPRQPTFTTRLDLDAAG--------AGAGRRGLLLCRVDSD 629 H+ + PA L + + + R+++ AA A A R +L R+ + Sbjct: 666 HTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAARE--VLARLHEE 723 Query: 630 PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLC 689 +L D+ A + G + G P+ +V + + + + ++ GLY C Sbjct: 724 AQLLAEL--SDQAAAVTWLKDGRTLSPG---PKYEVQASAGRRVLLVRDVARDDAGLYEC 778 Query: 690 EASNALGNASTSATFNGQATVLAIAPSHTLQE---GTEANLTCNVSREAAGSPANFSWFR 746 + G + + G A L + + + G A C S + + W++ Sbjct: 779 VSRG--GRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPAQFECETSE----AHVHVHWYK 832 Query: 747 NGVLWAQ----------GPLETVTLLPVARTDAALYACRILTEA---GAQLSTPVLLSVL 793 +G+ G + V R D Y+CR+ ++ ++S P ++ Sbjct: 833 DGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKVVFAK 892 Query: 794 YPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAK 853 R KL A G A C V + G+ L ++S + + Sbjct: 893 EQLARRKLQA----EAGASATLSCEVAQAQTEVTWYKDGKKLSSSS---------KVCME 939 Query: 854 AEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV-----QVSPSP-ELQ 907 A + +L V++ G D+G Y CEA G S V+ V QV+ S + + Sbjct: 940 ATGCTRRLVVQQAGQADAGEYSCEA----GGQRLSFHLDVKEPKVVFAKDQVAHSEVQAE 995 Query: 908 EGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSA---------TLRFAAITLTQAGAY 958 G + LSC+V T WY+DG+ L S L T AG Y Sbjct: 996 AGASATLSCEV---AQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDY 1052 Query: 959 HCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLL 1018 C+A+ S I+ + ++ + G +L C V Sbjct: 1053 SCEAR---GQRVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQTEVTWYK 1109 Query: 1019 HGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA-----SNTL 1073 G +L SS ++ + V T RL + A D G Y CEA S L Sbjct: 1110 DGKKL------------SSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSFHL 1157 Query: 1074 GQASASADF-DAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH 1132 F Q+V+ +V A G L+C V Q TWY+DG++ + Sbjct: 1158 HITEPKGVFAKEQSVHNEVQAEA----GTTAMLSCEV---AQPQTEVTWYKDGKKLSSSS 1210 Query: 1133 SIPL-----------PNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLL 1181 + + V DA Y C G G+ IT + + + Sbjct: 1211 KVRMEVKGCTRRLVVQQVGKADAGEYSCEAG--GQRVSFQLHITEPKAVFAKEQLVHNEV 1268 Query: 1182 ESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT---LRLELRGPQPRDEGF 1238 + G A + C V ++ ++ G+ L+SS+ + +L ++ D G Sbjct: 1269 RTEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGE 1327 Query: 1239 YSCSARSPLGQANTSLELRLEGVRVILAPE------AAVPEGAPITVTCADPAAHAPTLY 1292 Y+C A G S L + + + A E GA T++C A A T Sbjct: 1328 YTCEA----GGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSC--EVAQAQTEV 1381 Query: 1293 TWYHNGRWLQEGPAASLSFLVATR---------AHAGAYSCQAQDAQGTRSSRPAALQVL 1343 TWY +G+ L + + TR A G YSC+A + + S A +V+ Sbjct: 1382 TWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVV 1441 Query: 1344 YAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403 +A + V + ++A + + C V ++ E+ DGK L+ SS V A G Sbjct: 1442 FAKEQPVHREVQ-AQAGASTTLSCEV-AQAQTEVMWYKDGKKLSFSSKVRMEAVG----- 1494 Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNL 1463 R + Q AG+ + +Q L + V A + G + L Sbjct: 1495 CTRRLVVQQAGQAVAGEYSCEAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATL 1554 Query: 1464 SCRLLGGPGPVGNSTFAWFWNDRRLHAEP---------VPTLAFTHVARAQAGMYHCLA- 1513 SC + V W+ + ++L + L +A AG Y C A Sbjct: 1555 SCEVAQAQTEV-----TWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAG 1609 Query: 1514 --ELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSR 1571 L + P +V++ + P V+ E G L C V G + Sbjct: 1610 DQRLSFHLHVAEP---KVVFAKEQPAHRE-VQAEAGASATLSCEVAQAQTEVTWYKDGKK 1665 Query: 1572 LVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSA 1615 L +SS+ + V A R+ ++ +D GEY C A Sbjct: 1666 LSSSSK---------VRVEAVGCTRRLVVQQAGQADAGEYSCEA 1700 Score = 104 bits (260), Expect = 6e-22 Identities = 291/1322 (22%), Positives = 444/1322 (33%), Gaps = 219/1322 (16%) Query: 94 EHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEG 153 E + L+++ +D+G Y E S+ V+ TEE L Sbjct: 2877 EGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEE------------LTN 2924 Query: 154 TEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFN--------SQKFEPTGVGHLETLHMA 205 +V+ + + C E PA +VT+ S K +P+ G L ++ Sbjct: 2925 LQVEEKGTAVFTCKTEH---------PAATVTWRKGLLELRASGKHQPSQEGLTLRLTIS 2975 Query: 206 MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVN 265 + C + A RAQ + + V I+ ++ G T C+++ Sbjct: 2976 ALEKADSDTYTCDIGQAQSRAQLLVQ------GRRVHIIEDLEDVDVQEGSSATFRCRIS 3029 Query: 266 SSYPAVSSIKWLKDGVRLQTKT-----------GVLHLPQAAWSDAG-VYTCQAENGVGS 313 + + W D L VL L Q A D+G +Y + + Sbjct: 3030 PAN--YEPVHWFLDKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEAGDQRASA 3087 Query: 314 LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLE----- 368 + +F E+ + I E + +TLVC T + D+ W K+ L Sbjct: 3088 ALRVTEKPSVFSRELTDAT---ITEGEDLTLVCET---STCDIPVCWTKDGKTLRGSARC 3141 Query: 369 ----DAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQ 424 + H L + AT D+G Y CE G S + V P LE Sbjct: 3142 QLSHEGHRAQLLITGATLQDSGRYKCEA----GGACSSSIVRVHARPVRFQEALKDLEVL 3197 Query: 425 AGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEET 484 G L C V+S A + +G ++L GD +S R G L L +R+L Sbjct: 3198 EGGAATLRC-VLSSVAAPVKWCYGNNVLRP--GDK-YSLRQEGAM----LELVVRNLRPQ 3249 Query: 485 DSGEYKCSATNSLGNATSTLDFHANAARLLIS-PAAEVVEGQAVTLSCR-SGLSPTPDAR 542 DSG Y CS + +AT T+ A A+ + E EG TL C S +P + Sbjct: 3250 DSGRYSCSFGDQTTSATLTVT--ALPAQFIGKLRNKEATEGATATLRCELSKAAPVEWRK 3307 Query: 543 FSWYLNG----ALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598 S L L +G L + + DA Y C + ++ A LT+ P Sbjct: 3308 GSETLRDGDRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTS------ASLTI--RP 3359 Query: 599 RQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGG 658 F RL + GA L C + P R SL G Sbjct: 3360 MPAHFIGRLRHQESIEGA--TATLRCELSKAAPVEW------RKGRESLRDG-------- 3403 Query: 659 CSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAP--- 715 R + + + ++I + + G Y C G TSAT +A Sbjct: 3404 --DRHSLRQDGAVCELQICGLAVADAGEYSC----VCGEERTSATLTVKALPAKFTEGLR 3457 Query: 716 SHTLQEGTEANLTCNVSR----EAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAAL 771 + EG A L C +S+ E P N +L +G + + +A DA Sbjct: 3458 NEEAVEGATAMLWCELSKVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGE 3517 Query: 772 YACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFH 831 Y C E + T L + D A +G A+ C ++S A + Sbjct: 3518 YLCVCGQERTSATLTIRALPARFIEDVKNQEA----REGATAVLQCELNS--AAPVEWRK 3571 Query: 832 GEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFF 891 G L R+ + + +L++R L + D+G Y C V G TS Sbjct: 3572 GSETLRDG--------DRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAML 3619 Query: 892 QVRGAWVQVSP---SPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL---------QE 939 VR ++ + + E EG VL C++ P W++ + L Q+ Sbjct: 3620 TVRALPIKFTEGLRNEEATEGATAVLRCELSKMAP----VEWWKGHETLRDGDRHSLRQD 3675 Query: 940 STSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGR 999 L+ + AG Y C G TS + S + + + G Sbjct: 3676 GARCELQIRGLVAEDAGEYLCMC---GKERTSAMLTVRAMPS---KFIEGLRNEEATEGD 3729 Query: 1000 LGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAML 1059 L C + P + R H TL+ R + + L+I G + Sbjct: 3730 TATLWCELSKAAPVEWRKGH------ETLR-------DGDRHSLRQDGSRCELQIRGLAV 3776 Query: 1060 EDEGVYIC-----EASNTLGQASASADFDAQAVNVQVWPGAT-VREGQLVNLTCLVWTTH 1113 D G Y C S TL + A F N + GAT V + +L + W Sbjct: 3777 VDAGEYSCVCGQERTSATLTVRALPARFIEDVKNQEAREGATAVLQCELSKAAPVEWRKG 3836 Query: 1114 PAQL----TYTWYQDGQQ-RLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV 1168 L Y+ QDG + L H + +V D Y C G + L+ V Sbjct: 3837 SETLRGGDRYSLRQDGTRCELQIHGL-----SVADTGEYSCVCGQERTSATLTVRAPQPV 3891 Query: 1169 LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPN----TL 1224 P L++ G A + C + S P A + S G L + P T Sbjct: 3892 FREP-----LQSLQAEEGSTATLQCEL-SEPTATVVWSKGG-LQLQANGRREPRLQGCTA 3944 Query: 1225 RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPE---AAVPEGAPITVTC 1281 L L+ Q D G Y+C+ G TS L + V E V EG + C Sbjct: 3945 ELVLQDLQREDTGEYTCTC----GSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLCC 4000 Query: 1282 ADPAAHAPTLYTWYHNG---------RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGT 1332 + A W + +Q+G AA L + AG Y+C Q Sbjct: 4001 --ELSRAGASVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSM 4058 Query: 1333 RS 1334 S Sbjct: 4059 AS 4060 Score = 103 bits (257), Expect = 1e-21 Identities = 274/1256 (21%), Positives = 423/1256 (33%), Gaps = 235/1256 (18%) Query: 274 IKWLKDGVRL--------QTKTGVLHLPQAAW---SDAGVYTCQA-ENGVGSLVSPPISL 321 + W KDG+ L Q G H AA D G Y+C+ E+ V + Sbjct: 828 VHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPK 887 Query: 322 HIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH---------S 372 +F E + TL C A + +WYK+ L + + Sbjct: 888 VVFAKEQLARRKLQAEAGASATLSCEV---AQAQTEVTWYKDGKKLSSSSKVCMEATGCT 944 Query: 373 HTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLT----PVLTAFLETQAGLV 428 L + A +AD G Y CE G +R + V P + V + ++ +AG Sbjct: 945 RRLVVQQAGQADAGEYSCEA----GGQRLS-FHLDVKEPKVVFAKDQVAHSEVQAEAGAS 999 Query: 429 GILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGE 488 L C V + G + +S + + RL ++ +TD+G+ Sbjct: 1000 ATLSCEVAQAQTEVMWYKDGKKLSSSLKVHVE--------AKGCRRRLVVQQAGKTDAGD 1051 Query: 489 YKCSATNSLGNATSTLDFHANAARLLISPAAEVVE------GQAVTLSCRSGLSPTPDAR 542 Y C A + H +++ + V G + LSC + T Sbjct: 1052 YSCEARGQ----RVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQT---E 1104 Query: 543 FSWYLNGALLH---------EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLT 593 +WY +G L +G L+LP A DAG Y C A G + Sbjct: 1105 VTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEA-------GGQRVSFHL 1157 Query: 594 VLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGC 653 + P+ + + A AG +L C V P +KD +S S Sbjct: 1158 HITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQ--PQTEVTWYKDGKKLSS--SSKVR 1213 Query: 654 STCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAI 713 GC+ R+ V + + G Y CEA S V A Sbjct: 1214 MEVKGCTRRLVVQQVGKA-----------DAGEYSCEAGGQ--RVSFQLHITEPKAVFAK 1260 Query: 714 APSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLETVTLLPV 764 + TEA + +S E A + +W+++G + A G + + + Sbjct: 1261 EQLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQA 1320 Query: 765 ARTDAALYACRILTEAGAQ-------LSTPVLLSVLYPPDRPKLSALLDMGQGHMALFIC 817 + DA Y C EAG Q +S P + K+ A G +A C Sbjct: 1321 GQADAGEYTC----EAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQA----EAGAIATLSC 1372 Query: 818 TVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCE 877 V + G+ L ++S + + +A + +L V++ D+G Y CE Sbjct: 1373 EVAQAQTEVTWYKDGKKLSSSS---------KVRMEAVGCTRRLVVQQACQADTGEYSCE 1423 Query: 878 ATNVLGSSNTSLFFQVRGAWV------QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWY 931 A G S V V V + Q G + LSC+V T WY Sbjct: 1424 A----GGQRLSFSLDVAEPKVVFAKEQPVHREVQAQAGASTTLSCEV---AQAQTEVMWY 1476 Query: 932 RDGQPLQESTSATLRFAAITLTQ-----------AGAYHCQAQAPGSATTSLAAPISLHV 980 +DG+ L S S+ +R A+ T+ AG Y C+A GS S ++ Sbjct: 1477 KDGKKL--SFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCEA---GSQRLSFHLHVAEPK 1531 Query: 981 SYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPR 1040 + + + + G L C V G +L SS + Sbjct: 1532 AVFAKEQPASREVQAEAGTSATLSCEVAQAQTEVTWYKDGKKL------------SSSSK 1579 Query: 1041 LHVAVAPNTLRLEIHGAMLEDEGVYICEASNT-----LGQASASADFDAQAV---NVQVW 1092 + + T RL + A D G Y C+A + L A F + VQ Sbjct: 1580 VRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAE 1639 Query: 1093 PGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVR---------- 1142 GA+ L+C V AQ TWY+DG++ + + + V Sbjct: 1640 AGASA------TLSCEV---AQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQ 1690 Query: 1143 -DATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALV--LCTVDSRP 1199 DA Y C G + RL L+ + R R L+ + L L T + Sbjct: 1691 ADAGEYSCEAGGQRLSFRL-HVAELEPQISERPCRREPLVVKEHEDIILTATLATPSAAT 1749 Query: 1200 PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE 1259 L R AS +T L + G Q D YSC +G +++E Sbjct: 1750 VTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCR----VGAEGQDFPVQVE 1805 Query: 1260 GVRV----ILAPEAAVPEGAPITVTCADPAAHAPTLY----TWYHNGRWLQ---EGPAAS 1308 V +L P G +T+ C A A ++ T G+ Q EGP S Sbjct: 1806 EVAAKFCRLLEPVCG-ELGGTVTLACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRS 1864 Query: 1309 LSFLVATRAHAGAYSCQAQD----AQGTRS------------------SRPAALQVLYAP 1346 L+ L AG Y C+++D AQ T S A Q + +P Sbjct: 1865 LTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVVSP 1924 Query: 1347 QDAVLSSFRDSR----ARSMAVIQCTVD-SEPPAELALSHDGKVLATSSGVHSLAS 1397 D + FRD + A+ Q S ++L L G++ + G S A+ Sbjct: 1925 SDVAVVWFRDGALLQPSEKFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAA 1980 Score = 102 bits (255), Expect = 2e-21 Identities = 283/1294 (21%), Positives = 450/1294 (34%), Gaps = 235/1294 (18%) Query: 59 WYYDYSGQRQVVSHSADPKLVEARFRG--------RTEFMGNPEHRVCNLLLKDLQPEDS 110 W G+R V + D LVE + G E++ PE L + D+ E Sbjct: 533 WSPPPHGERPV---TIDGYLVEKKKLGTYTWIRCHEAEWVATPE-----LTVADVAEEG- 583 Query: 111 GSYNFRFEISEVNRWS-----DVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYV 165 NF+F +S +N + + GT V + + V T V+ +EG EV F+ Sbjct: 584 ---NFQFRVSALNSFGQSPYLEFPGT-VHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVA 639 Query: 166 CLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLE---TLHMAMSWQDHGRILRCQLSVA 222 E W + Q + + V + T H + + QL Sbjct: 640 SAGE-----W---------FLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFV 685 Query: 223 NHRAQSEIHLQVKYAPKGVKILLSPSG--RNILPG--ELVTLTCQVNSSYPAVSSIKWLK 278 + +S I ++V+ AP G+ P+ R +L E L +++ AV+ WLK Sbjct: 686 ANGIESSIRMEVRAAP-GLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVT---WLK 741 Query: 279 DGVRL--------QTKTG--VLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEV 328 DG L Q G VL + A DAG+Y C + G + L F+ + Sbjct: 742 DGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKD 801 Query: 329 QVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHV---------LLEDAHS-HTLRLH 378 + C T + + + WYK+ + L ED + H L Sbjct: 802 MAGSCVDAVAGGPAQFECET---SEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAA 858 Query: 379 LATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLT----PVLTAFLETQAGLVGILHCS 434 TR D G Y C V E S + V+ P + + L+ +AG L C Sbjct: 859 TVTRQDEGTYSCRV-----GEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSCE 913 Query: 435 VVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSAT 494 V G + +S+ + + + RL ++ + D+GEY C A Sbjct: 914 VAQAQTEVTWYKDGKKLSSSS--------KVCMEATGCTRRLVVQQAGQADAGEYSCEAG 965 Query: 495 NSLGNATSTLDFHANAARLLISPAAEVVE--------GQAVTLSCRSGLSPTPDARFSWY 546 L FH + + A + V G + TLSC + T WY Sbjct: 966 GQ------RLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSCEVAQAQT---EVMWY 1016 Query: 547 LNGALLH---------EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYP 597 +G L +G L++ A TDAG Y C AR G S +++ Sbjct: 1017 KDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEAR-GQRVSFRLHITEPKMMFA 1075 Query: 598 PRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLL-HKDRVVATSLPSGGGCSTC 656 Q + A AG +L C V A+ ++ +KD +S G Sbjct: 1076 KEQSVH------NEVQAEAGASAMLSCEV---AQAQTEVTWYKDGKKLSSSSKVG--MEV 1124 Query: 657 GGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPS 716 GC+ R+ + +A + G Y CEA S V A S Sbjct: 1125 KGCTRRLVLPQAGK-----------ADAGEYSCEAGGQ--RVSFHLHITEPKGVFAKEQS 1171 Query: 717 HTLQEGTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLETVTLLPVART 767 + EA T +S E A +W+++G + +G + + V + Sbjct: 1172 VHNEVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKA 1231 Query: 768 DAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLD----MGQGHMALFICTVDSRP 823 DA Y+C EAG Q L + P L+ G A C V Sbjct: 1232 DAGEYSC----EAGGQ-RVSFQLHITEPKAVFAKEQLVHNEVRTEAGASATLSCEVAQAQ 1286 Query: 824 LALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLG 883 + G+ L ++S + + +A +L V++ G D+G Y CEA G Sbjct: 1287 TEVTWYKDGKKLSSSS---------KVRIEAAGCMRQLVVQQAGQADAGEYTCEA----G 1333 Query: 884 SSNTSLFFQVRGAWVQVSPSP------ELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL 937 S V + + + G LSC+V E T WY+DG+ L Sbjct: 1334 GQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQTEVT---WYKDGKKL 1390 Query: 938 QESTSATLRFAAITLTQ-----------AGAYHCQAQAPG-SATTSLAAPISLHVSYAPR 985 S+S+ +R A+ T+ G Y C+A S + +A P + P Sbjct: 1391 --SSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVFAKEQPV 1448 Query: 986 HVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAV 1045 H + G L C V + G +L S ++ + Sbjct: 1449 H----REVQAQAGASTTLSCEVAQAQTEVMWYKDGKKL------------SFSSKVRMEA 1492 Query: 1046 APNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNL 1105 T RL + A G Y CEA + + +AV + P + + + Sbjct: 1493 VGCTRRLVVQQAGQAVAGEYSCEAGSQRLSFHLHV-AEPKAVFAKEQPASREVQAEAGTS 1551 Query: 1106 TCLVWTTHPAQLTYTWYQDGQQ-------RLDA----HSIPLPNVTVRDATSYRCGVGPP 1154 L AQ TWY+DG++ R++A + + DA Y C G Sbjct: 1552 ATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQ 1611 Query: 1155 GRAPRL--SRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLL 1212 + L + P + P + +++ G A + C V ++ ++ G+ L Sbjct: 1612 RLSFHLHVAEPKVVFAKEQPAHRE----VQAEAGASATLSCEV-AQAQTEVTWYKDGKKL 1666 Query: 1213 ASST---AASVPNTLRLELRGPQPRDEGFYSCSA 1243 +SS+ +V T RL ++ D G YSC A Sbjct: 1667 SSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA 1700 Score = 94.7 bits (234), Expect = 7e-19 Identities = 329/1543 (21%), Positives = 511/1543 (33%), Gaps = 276/1543 (17%) Query: 229 EIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSS-YPAVSSIKWLKDGVRLQTKT 287 ++ + A + LL P+ + G T C+V S PAVS W KDG RL Sbjct: 98 QVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVS---WSKDGRRLGEPD 154 Query: 288 G------------VLHLPQAAWSDAGVYTCQAENGVGSLVS----------------PPI 319 G L + A D G Y +AEN +G+ + P Sbjct: 155 GPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGT 214 Query: 320 SLHIFMAEVQV---------SPAGP---------ILENQTVTLVCNTPNEAPSDLRYSWY 361 S +A +Q +PA P + E + L C E + W Sbjct: 215 STAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPET--VWK 272 Query: 362 KN---------HVLLEDAHSH-TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHP 411 K+ HV+ EDA + L++ ++D G Y C N+ G S + VV Sbjct: 273 KDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVV--RE 330 Query: 412 PLTPVLTAF--LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTS 469 P P LE + C V + AS + GT Sbjct: 331 PAVPFKKRLQDLEVREKESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEE----GTE 386 Query: 470 GPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTL 529 RL +R++ D Y C + L N R L P V + Sbjct: 387 R----RLTVRNVSADDDAVYICETPEG-SRTVAELAVQGNLLRKL--PRKTAVRVGDTAM 439 Query: 530 SCRSGLSPTPDARFSWYLNG---------ALLHEGPGSSLLLPAASSTDAGSY-----HC 575 C P W N A+ EG +L + D G C Sbjct: 440 FCVELAVPVGPVH--WLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDC 497 Query: 576 RARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635 + S P P L PP P R++ + S PP + Sbjct: 498 QTSTQFCVSAPRKPP----LQPPVDPVVKARMESSVILSW------------SPPPHGER 541 Query: 636 LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695 + D + G T C V P L ++ EEG + S AL Sbjct: 542 PVTIDGYLVEKKKLG--TYTWIRCHEAEWVA-TPELTVADV-----AEEGNFQFRVS-AL 592 Query: 696 GNASTSATFNGQATV-----LAI-APSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRN 747 + S TV LA+ P +Q EG E + +++ +AG WF + Sbjct: 593 NSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVASAGE-----WFLD 647 Query: 748 G-VLWAQGPLE-----TVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPP----D 797 G L A E T L + A+L+ ++ A + + + + V P + Sbjct: 648 GQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANG-IESSIRMEVRAAPGLTAN 706 Query: 798 RPKLSALLD-MGQGHM-ALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAE 855 +P +A + + + H A + + + A+ L G L S GP +++ +A Sbjct: 707 KPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTL---SPGP------KYEVQAS 757 Query: 856 ANSLKLEVRELGLGDSGSYRCEA--------TNVLGSSNTSLFFQVRGAWVQ-VSPSPEL 906 A L VR++ D+G Y C + +V G + L + G+ V V+ P Sbjct: 758 AGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLAR-FLHKDMAGSCVDAVAGGPAQ 816 Query: 907 QEGQAVVLSCQVHTGVPEGTSYRWYRDGQP--------LQESTSATLRFAAITLTQ--AG 956 E + VH WY+DG LQE R A T+T+ G Sbjct: 817 FECETSEAHVHVH----------WYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEG 866 Query: 957 AYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLR 1016 Y C+ G + +S + + G L C V Sbjct: 867 TYSCRV---GEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVTW 923 Query: 1017 LLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQA 1076 G +L SS ++ + T RL + A D G Y CEA G Sbjct: 924 YKDGKKL------------SSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEA----GGQ 967 Query: 1077 SASADFDAQAVNV-----QVWPGATVRE-GQLVNLTCLVWTTHPAQLTYTWYQDGQQ--- 1127 S D + V QV E G L+C V AQ WY+DG++ Sbjct: 968 RLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSCEV---AQAQTEVMWYKDGKKLSS 1024 Query: 1128 RLDAH--------SIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY 1179 L H + + DA Y C G+ IT + + + Sbjct: 1025 SLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEA--RGQRVSFRLHITEPKMMFAKEQSVHN 1082 Query: 1180 LLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVP---NTLRLELRGPQPRDE 1236 +++ G A++ C V ++ ++ G+ L+SS+ + T RL L D Sbjct: 1083 EVQAEAGASAMLSCEV-AQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADA 1141 Query: 1237 GFYSCSARSPLGQANTSLELRLEGVRVILAPEAA----VPEGAPITVTCADPAAHAPTLY 1292 G YSC A G S L + + + A E + V A T + A T Sbjct: 1142 GEYSCEA----GGQRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEV 1197 Query: 1293 TWYHNGRWLQEGPAASLSFLVATR---------AHAGAYSCQAQDAQGTRSSRPAALQVL 1343 TWY +G+ L + TR A AG YSC+A + + + + Sbjct: 1198 TWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEPKAV 1257 Query: 1344 YAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403 +A + V + R + A + A + C V ++ E+ DGK L++SS V A+G Sbjct: 1258 FAKEQLVHNEVR-TEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRIEAAG----- 1310 Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNL 1463 R + Q AG+ T Q L + V +A + GA L Sbjct: 1311 CMRQLVVQQAGQADAGEYTCEAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATL 1370 Query: 1464 SCRLLGGPGPVGNSTFAWFWNDRRLHAEP---------VPTLAFTHVARAQAGMYHCLAE 1514 SC + V W+ + ++L + L +A G Y C A Sbjct: 1371 SCEVAQAQTEV-----TWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAG 1425 Query: 1515 LPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVA 1574 + + +V++ + P V+ + G L C V + G +L Sbjct: 1426 GQRLSFSLDVAEPKVVFAKEQPVHRE-VQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSF 1484 Query: 1575 SSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASN 1617 SS+ + + A R+ ++ + GEY C A + Sbjct: 1485 SSK---------VRMEAVGCTRRLVVQQAGQAVAGEYSCEAGS 1518 Score = 94.7 bits (234), Expect = 7e-19 Identities = 362/1685 (21%), Positives = 573/1685 (34%), Gaps = 282/1685 (16%) Query: 78 LVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTE 137 L+E R G+ + + E L + L+ DS +Y ++ V+G V + E Sbjct: 2952 LLELRASGKHQ--PSQEGLTLRLTISALEKADSDTYTCDIGQAQSRAQLLVQGRRVHIIE 3009 Query: 138 EPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQW-QGQDPARSVTFNSQKFEPTGV 196 + V++ EG+ F C + + W + P + N +P G Sbjct: 3010 D------LEDVDVQEGSSATFRCR---ISPANYEPVHWFLDKTPLHANELNEIDAQPGGY 3060 Query: 197 GHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGE 256 H+ TL ++ +D G I + RA + + + K + ++ + I GE Sbjct: 3061 -HVLTLRQ-LALKDSGTIY---FEAGDQRASAALRVTEKPSVFSREL----TDATITEGE 3111 Query: 257 LVTLTCQVNSSYPAVSSIKWLKDGVRLQTKT----------GVLHLPQAAWSDAGVYTCQ 306 +TL C+ ++ V W KDG L+ L + A D+G Y C+ Sbjct: 3112 DLTLVCETSTCDIPVC---WTKDGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKCE 3168 Query: 307 AENGVGSLV----SPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYK 362 A S + + P+ + +++V LE TL C + A W Sbjct: 3169 AGGACSSSIVRVHARPVRFQEALKDLEV------LEGGAATLRCVLSSVAAP---VKWCY 3219 Query: 363 NHVLLEDAHSHTLR-----LHLATR----ADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413 + +L ++LR L L R D+G Y C G + + V P Sbjct: 3220 GNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSF----GDQTTSATLTVTALPAQ 3275 Query: 414 TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNS 473 E G L C + A + G L GD R+ Sbjct: 3276 FIGKLRNKEATEGATATLRCEL--SKAAPVEWRKGSETLRD--GD-----RYCLRQDGAM 3326 Query: 474 LRLEIRDLEETDSGEYKCSATNSLGNATSTL-DFHANAARLLISPAAEVVEGQAVTLSCR 532 L+IR L D+ EY C +A+ T+ A+ L E +EG TL C Sbjct: 3327 CELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFIGRL--RHQESIEGATATLRCE 3384 Query: 533 SGLSPTPDARFSWYLNGALLHEGPGSSLLLPAA---------SSTDAGSYHCRARDGHSA 583 + A W L +G SL A + DAG Y C + ++ Sbjct: 3385 LSKA----APVEWRKGRESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSCVCGEERTS 3440 Query: 584 SGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVV 643 A LTV P + FT L + A GA +L C + P R Sbjct: 3441 ------ATLTVKALPAK--FTEGLRNEEAVEGA--TAMLWCELSKVAPVEW------RKG 3484 Query: 644 ATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSAT 703 +L G R + + ++I + + G YLC G TSAT Sbjct: 3485 PENLRDG----------DRYILRQEGTRCELQICGLAMADAGEYLC----VCGQERTSAT 3530 Query: 704 FNGQ---ATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSW------FRNG---VLW 751 + A + + +EG A L C ++ S A W R+G L Sbjct: 3531 LTIRALPARFIEDVKNQEAREGATAVLQCELN-----SAAPVEWRKGSETLRDGDRYSLR 3585 Query: 752 AQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGH 811 G + + +A D Y+C E + + T L + + A +G Sbjct: 3586 QDGTKCELQIRGLAMADTGEYSCVCGQERTSAMLTVRALPIKFTEGLRNEEAT----EGA 3641 Query: 812 MALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDS 871 A+ C + +A + + G L R + + +L++R L D+ Sbjct: 3642 TAVLRCELSK--MAPVEWWKGHETLRDG--------DRHSLRQDGARCELQIRGLVAEDA 3691 Query: 872 GSYRCEATNVLGSSNTSLFFQVR---GAWVQVSPSPELQEGQAVVLSCQVHTGVPE--GT 926 G Y C + G TS VR +++ + E EG L C++ P Sbjct: 3692 GEYLC----MCGKERTSAMLTVRAMPSKFIEGLRNEEATEGDTATLWCELSKAAPVEWRK 3747 Query: 927 SYRWYRDGQP---LQESTSATLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSY 982 + RDG Q+ + L+ + + AG Y C Q SAT ++ A Sbjct: 3748 GHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTSATLTVRA-------L 3800 Query: 983 APRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLH 1042 R + + G +L C + P + R + TL+G R Sbjct: 3801 PARFIEDVKNQEAREGATAVLQCELSKAAPVEW------RKGSETLRG-------GDRYS 3847 Query: 1043 VAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQA---VNVQVWPGATVRE 1099 + L+IHG + D G Y C GQ SA +A V + E Sbjct: 3848 LRQDGTRCELQIHGLSVADTGEYSC----VCGQERTSATLTVRAPQPVFREPLQSLQAEE 3903 Query: 1100 GQLVNLTC--------LVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGV 1151 G L C +VW+ QL ++ + + + L ++ D Y C Sbjct: 3904 GSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTC 3963 Query: 1152 GPPGRAPRLSRPITLDVLYAP-RNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAG- 1209 G + TL V AP R LR E G A + C + SR A + Sbjct: 3964 GSQATS------ATLTVTAAPVRFLRELQHQEVDEGGTAHLCCEL-SRAGASVEWRKGSL 4016 Query: 1210 RLLASSTAASVPNTLRLEL--RGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP 1267 +L + V + EL RG + D G Y+C Q+ SL +R+ + Sbjct: 4017 QLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHT--QSMASLSVRVPRPKFKTRL 4074 Query: 1268 EAAVPEGAPITVTCADPA-AHAPTLYTWYHNGRWLQEGPAASLSFLVATR---------A 1317 ++ E I C + A + + W G L GP + ATR Sbjct: 4075 QSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEAK 4134 Query: 1318 HAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQ--CTVDSEPPA 1375 G Y+C T + AA + P+ ++ D+ + ++ C V Sbjct: 4135 DTGEYACV------TGGQKTAASLRVTEPEVTIVRGLVDAEVTADEDVEFSCEVSRAGAT 4188 Query: 1376 ELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQ-VQDVPAGDDTYVCTAQNLLGSI 1434 + G L S+ V +A G + + LRL+ V AG T LG+ Sbjct: 4189 GVQWCLQGLPL-QSNEVTEVAVRDGRI----HTLRLKGVTPEDAG------TVSFHLGNH 4237 Query: 1435 STIGRLQVEGARV-VAEPGLDV--PEGAALNLSCRLLGGPGPV------GNSTFAWFWND 1485 ++ +L V V + EP DV EG + CRL G G A ND Sbjct: 4238 ASSAQLTVRAPEVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMND 4297 Query: 1486 RRLHAEPVPTLAFTHVARAQAG--MYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVE 1543 + + L V AG +H S+ L+V + VE Sbjct: 4298 ITVEQGTLHLLTLHKVTLEDAGTVSFHV-------GTCSSEAQLKVTAKNTVVRGLENVE 4350 Query: 1544 PEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALR--VDIE 1601 G + +C++ +A+ T L V +S+ + V+ N LR + ++ Sbjct: 4351 ALEGGEALFECQLSQPEVAAHTWLLDDEPVHTSE--------NAEVVFFENGLRHLLLLK 4402 Query: 1602 ALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGL--LLLLLGL 1659 LRP D C + + G TS + VR W L +L L + G Sbjct: 4403 NLRPQDS----CRVTFLAGDMVTSAFLTVRG-----------WRLEILEPLKNAAVRAGA 4447 Query: 1660 GACYT 1664 AC+T Sbjct: 4448 QACFT 4452 Score = 85.9 bits (211), Expect = 3e-16 Identities = 282/1247 (22%), Positives = 418/1247 (33%), Gaps = 244/1247 (19%) Query: 508 ANAARLLISPAAEVVE-GQAVTLSCRSGLSPTPDARFSWYLN------GA---LLHEGPG 557 + A R L P A VV G+ TLSC+ +PTP SW + GA L +G Sbjct: 7 SGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQV--SWEKDQQPVAAGARFRLAQDGDL 64 Query: 558 SSLLLPAASSTDAGSYHCRARD--GHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAG 615 L + + D+G Y CRAR+ G + + + P F R + Sbjct: 65 YRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPT--SIRVR 122 Query: 616 AGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVE 675 G CRV P + R + P G PR++V + + Sbjct: 123 EGSEATFRCRVGGSPRPAVSWSKDGRRLGE--PDG----------PRVRVEELGEASALR 170 Query: 676 IHNPLLEEEGLYLCEASNALGNASTSA----------TFNGQATVLAIAPSH-------- 717 I + G Y A N LG AS +A T + T A +H Sbjct: 171 IRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAM 230 Query: 718 -----------------TLQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETV- 759 T+ EG A L+C V+ E W ++G L +G V Sbjct: 231 RAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETV---WKKDGQLVTEGRRHVVY 287 Query: 760 ---------TLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP--PDRPKLSALLDMG 808 +L ++D LY C G Q + VL+ V P P + +L L++ Sbjct: 288 EDAQENFVLKILFCKQSDRGLYTCTASNLVG-QTYSSVLVVVREPAVPFKKRLQD-LEVR 345 Query: 809 QGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGL 868 + A F+C V +P A F E L S ++ + E +L VR + Sbjct: 346 EKESATFLCEV-PQPSTEAAWFKEETRLWAS--------AKYGIEEEGTERRLTVRNVSA 396 Query: 869 GDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSY 928 D Y CE S T V+G ++ P + C V VP G + Sbjct: 397 DDDAVYICETPE---GSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFC-VELAVPVGPVH 452 Query: 929 RWYRDGQPL---------QESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLH 979 W R+ + + E T TL + L G A G TS +S Sbjct: 453 -WLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMA---GDCQTSTQFCVS-- 506 Query: 980 VSYAPRHVTLTTLMD-TGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSS 1038 APR L +D R+ + S PP HG+R V T+ G + Sbjct: 507 ---APRKPPLQPPVDPVVKARMESSVILSWSPPP------HGERPV--TIDGYLVEKKKL 555 Query: 1039 P-----RLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWP 1093 R H A T L + E + A N+ GQ S +F V + P Sbjct: 556 GTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQ-SPYLEFPG---TVHLAP 611 Query: 1094 GATVR---------EGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSI-------PLP 1137 VR EG V + + + W+ DG Q L A S+ Sbjct: 612 KLAVRTPLKAVQAVEGGEVTFSVDLTVASAGE----WFLDG-QALKASSVYEIHCDRTRH 666 Query: 1138 NVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAP-----------------RNLRLTYL 1180 +T+R+ + G A + I ++V AP R L Sbjct: 667 TLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQL 726 Query: 1181 LESHGGQLALVLCTVDSRP----PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDE 1236 L Q A V D R P + AGR + L +R D Sbjct: 727 LAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRV-------------LLVRDVARDDA 773 Query: 1237 GFYSCSARSPLGQANTSLELRLEGVRVILAPEAA-----VPEGAPITVTCADPAAHAPTL 1291 G Y C +R + +L ++G+ L + A G P C AH Sbjct: 774 GLYECVSRG----GRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPAQFECETSEAHVHV- 828 Query: 1292 YTWYHNG--------RWLQE--GPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQ 1341 WY +G R+LQE G L TR G YSC+ + R + + Sbjct: 829 -HWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPK 887 Query: 1342 VLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGH 1401 V++A + + + A + A + C V ++ E+ DGK L++SS V A+G Sbjct: 888 VVFAKEQLARRKLQ-AEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVCMEATG--- 942 Query: 1402 VQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAAL 1461 R + Q AG+ + Q L + V VA + GA+ Sbjct: 943 --CTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASA 1000 Query: 1462 NLSCRLLGGPGPVGNSTFAWFWNDRRL------HAEPV---PTLAFTHVARAQAGMYHCL 1512 LSC + V W+ + ++L H E L + AG Y C Sbjct: 1001 TLSCEVAQAQTEV-----MWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCE 1055 Query: 1513 AELPTGAAASAPVMLRVLYP----PKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHL 1568 A L + P K ++ V+ E G +L C V ++ +T + Sbjct: 1056 AR-----GQRVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEV-AQAQTEVTWYK 1109 Query: 1569 GSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSA 1615 + ++SS G + L P A + +D GEY C A Sbjct: 1110 DGKKLSSSSKVGMEVKGCTRRLVLPQAGK--------ADAGEYSCEA 1148 Score = 81.6 bits (200), Expect = 6e-15 Identities = 277/1174 (23%), Positives = 409/1174 (34%), Gaps = 187/1174 (15%) Query: 255 GELVTLTCQVNSSYPAVSSIKW------LKDG----VRLQTKTGVLHLPQAAWSDAGVYT 304 G L C+++ V+ ++W L+DG +R + L + A +DAG Y Sbjct: 3464 GATAMLWCELSK----VAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYL 3519 Query: 305 CQA--ENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYK 362 C E +L + F+ +V+ A E T L C + AP + W K Sbjct: 3520 CVCGQERTSATLTIRALPAR-FIEDVKNQEAR---EGATAVLQCELNSAAPVE----WRK 3571 Query: 363 NHVLLEDAHSHTLR---------LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413 L D ++LR + ADTG Y C V G ER+ + V P Sbjct: 3572 GSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAMLTVRALPIK 3627 Query: 414 TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSD-HSPRFSGTSGPN 472 E G +L C + H T D D HS R G Sbjct: 3628 FTEGLRNEEATEGATAVLRCELSKMAPVEWWKGH------ETLRDGDRHSLRQDGAR--- 3678 Query: 473 SLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA-AEVVEGQAVTLSC 531 L+IR L D+GEY C +A T+ A ++ + E EG TL C Sbjct: 3679 -CELQIRGLVAEDAGEYLCMCGKERTSAMLTV--RAMPSKFIEGLRNEEATEGDTATLWC 3735 Query: 532 R-SGLSPTPDARFSWYLNG----ALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGP 586 S +P + L +L +G L + + DAG Y C ++ Sbjct: 3736 ELSKAAPVEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTS--- 3792 Query: 587 SSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATS 646 A LTV P + F D+ A G +L C + P + Sbjct: 3793 ---ATLTVRALPAR--FIE--DVKNQEAREGATAVLQCELSKAAPVEWRK---------- 3835 Query: 647 LPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNG 706 G T G R + + ++IH + + G Y C G TSAT Sbjct: 3836 -----GSETLRG-GDRYSLRQDGTRCELQIHGLSVADTGEYSC----VCGQERTSATLTV 3885 Query: 707 QATVLAIA-PSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRNGV-LWAQGPLET---- 758 +A P +LQ EG+ A L C +S A W + G+ L A G E Sbjct: 3886 RAPQPVFREPLQSLQAEEGSTATLQCELSEPTA----TVVWSKGGLQLQANGRREPRLQG 3941 Query: 759 ----VTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMAL 814 + L + R D Y C G+Q ++ L P + ++ +G A Sbjct: 3942 CTAELVLQDLQREDTGEYTCT----CGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAH 3997 Query: 815 FICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSY 874 C + SR A + G L ++Q + + +L VR + D+G Y Sbjct: 3998 LCCEL-SRAGASVEWRKGSLQLFPC--------AKYQMVQDGAAAELLVRGVEQEDAGDY 4048 Query: 875 RCEATNVLGSSNTSLFFQV-RGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRD 933 C+ + S SL +V R + S E + G L CQ+ + G +W ++ Sbjct: 4049 TCDTGHT--QSMASLSVRVPRPKFKTRLQSLEQETGDIARLCCQL-SDAESGAVVQWLKE 4105 Query: 934 GQPLQESTSATLRFAAITLTQAGAYHCQAQAPGS---ATTSLAAPISLHVSYAPRHVTLT 990 G L +R T + + +A+ G T SL V+ VT+ Sbjct: 4106 GVELHAGPKYEMRSQGAT-RELLIHQLEAKDTGEYACVTGGQKTAASLRVTEP--EVTIV 4162 Query: 991 TLMDTGPGRLGLLLCRVDSDPPAQLRL---LHGDRLVASTLQGVGGPEGSSPRLHVAVAP 1047 GL+ V +D + G V LQG+ P S+ VAV Sbjct: 4163 R---------GLVDAEVTADEDVEFSCEVSRAGATGVQWCLQGL--PLQSNEVTEVAVRD 4211 Query: 1048 NTLR-LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWP---GATVREGQLV 1103 + L + G ED G S LG ++SA +A V + + EGQ Sbjct: 4212 GRIHTLRLKGVTPEDAGT----VSFHLGNHASSAQLTVRAPEVTILEPLQDVQLSEGQDA 4267 Query: 1104 NLTCLV---------WTTHPAQLTYTWYQD-GQQRLDAHSIPLPNVTVRDATSYRCGVGP 1153 + C + W L D ++ H + L VT+ DA + VG Sbjct: 4268 SFQCRLSRASGQEARWALGGVPLQANEMNDITVEQGTLHLLTLHKVTLEDAGTVSFHVGT 4327 Query: 1154 PGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLA 1213 +L V+ N+ E+ G AL C + A + Sbjct: 4328 CSSEAQLKVTAKNTVVRGLENV------EALEGGEALFECQLSQPEVAAHTWLLDDEPVH 4381 Query: 1214 SSTAASV---PNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRV-ILAP 1267 +S A V N LR L L+ +P+D SC G TS L + G R+ IL P Sbjct: 4382 TSENAEVVFFENGLRHLLLLKNLRPQD----SCRVTFLAGDMVTSAFLTVRGWRLEILEP 4437 Query: 1268 --EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQ----------EGPAASLSFLVAT 1315 AAV GA TC A +WY NG +Q +G +L A Sbjct: 4438 LKNAAVRAGAQACFTCTLSEAVPVGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSAQ 4497 Query: 1316 RAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDA 1349 HAG + +DA S+R L + P+DA Sbjct: 4498 PHHAGEVTFACRDA--VASARLTVLGLPDPPEDA 4529 Score = 77.4 bits (189), Expect = 1e-13 Identities = 299/1338 (22%), Positives = 457/1338 (34%), Gaps = 238/1338 (17%) Query: 225 RAQSEIHLQVKYAPKGVKILLSP-SGRNILPGELVTLTCQVNSSYPAVSSIKWLKDG--- 280 +++S L V P + L P +GR + + V L+C PA +++W KD Sbjct: 2455 KSRSSARLVVSDIPVVLTRPLEPKTGREL---QSVVLSCDFR---PAPKAVQWYKDDTPL 2508 Query: 281 -------VRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPA 333 + L+ + L + + +DAGVY CQA GS S S + + +V+ Sbjct: 2509 SPSEKFKMSLEGQMAELRILRLMPADAGVYRCQA----GSAHS---STEVTVEAREVTVT 2561 Query: 334 GPI-----LENQTVTLVCNTPNEAPSDLRYSWYKN---------HVLLEDAHSHTLRLHL 379 GP+ E + C +E D W N H + HTL L Sbjct: 2562 GPLQDAEATEEGWASFSCELSHE---DEEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKS 2618 Query: 380 ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEP 439 RAD G V S R + V V L + G + L C VS+P Sbjct: 2619 IQRADAGIVRASSLKVSTSAR---LEVRVKPVVFLKALDDLSAEERGTLA-LQCE-VSDP 2673 Query: 440 LATLVLSHGGHILA-STSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG 498 A +V G L S D H+ +GT G L + D+ D+G Y C + Sbjct: 2674 EAHVVWRKDGVQLGPSDKYDFLHT---AGTRG-----LVVHDVSPEDAGLYTCHVGSEET 2725 Query: 499 NATSTL-DFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALL----- 552 A + D H + L EV+EG++ + C D W + G + Sbjct: 2726 RARVRVHDLHVGITKRL--KTMEVLEGESCSFECVLSHESASDPAM-WTVGGKTVGSSSR 2782 Query: 553 ----HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLD 608 +G L++ A+ +DAG S G +S A L V R+ Sbjct: 2783 FQATRQGRKYILVVREAAPSDAGEV------VFSVRGLTSKASLIV----RERPAAIIKP 2832 Query: 609 LDAAGAGAGRRGLLLCRVD-SDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTK 667 L+ G L C + + P KDR S + V Sbjct: 2833 LEDQWVAPGEDVELRCELSRAGTPVHWL---KDRKAIRK-------------SQKYDVVC 2876 Query: 668 APNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANL 727 + + I L++ G Y CE + AS + ++GT A Sbjct: 2877 EGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEELTNLQVEEKGT-AVF 2935 Query: 728 TCNVSREAAGSPANFSWFRNGVL----------WAQGPLETVTLLPVARTDAALYACRIL 777 TC A A +W R G+L +G +T+ + + D+ Y C I Sbjct: 2936 TCKTEHPA----ATVTW-RKGLLELRASGKHQPSQEGLTLRLTISALEKADSDTYTCDI- 2989 Query: 778 TEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLA 837 AQ +L+ L +D+ +G A F C + A + H Sbjct: 2990 --GQAQSRAQLLVQGRRVHIIEDLED-VDVQEGSSATFRCRISP------ANYEPVHWFL 3040 Query: 838 TSLGPQVPSHGRFQAKAEANS---LKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894 + P H + +A L +R+L L DSG+ EA G S +V Sbjct: 3041 ----DKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEA----GDQRASAALRVT 3092 Query: 895 ---GAWVQVSPSPELQEGQAVVLSCQVHT-GVPEGTSYRWYRDGQPLQ---------EST 941 + + + EG+ + L C+ T +P W +DG+ L+ E Sbjct: 3093 EKPSVFSRELTDATITEGEDLTLVCETSTCDIP----VCWTKDGKTLRGSARCQLSHEGH 3148 Query: 942 SATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLG 1001 A L TL +G Y C +A G+ ++S+ + V + L L G Sbjct: 3149 RAQLLITGATLQDSGRYKC--EAGGACSSSIVRVHARPVRFQEALKDLEVL----EGGAA 3202 Query: 1002 LLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061 L C V S A ++ +G+ ++ + EG+ L L + +D Sbjct: 3203 TLRC-VLSSVAAPVKWCYGNNVLRPGDKYSLRQEGA-----------MLELVVRNLRPQD 3250 Query: 1062 EGVYICE-----ASNTLGQASASADFDAQAVNVQVWPGATVR-EGQLVNLTCLVWTTHPA 1115 G Y C S TL + A F + N + GAT +L + W Sbjct: 3251 SGRYSCSFGDQTTSATLTVTALPAQFIGKLRNKEATEGATATLRCELSKAAPVEWRKGSE 3310 Query: 1116 QL----TYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYA 1171 L Y QDG + + + + DA Y C G R S +T+ + A Sbjct: 3311 TLRDGDRYCLRQDGAM----CELQIRGLAMVDAAEYSCVCG----EERTSASLTIRPMPA 3362 Query: 1172 PRNLRLTYLLESHGGQLALVLCTVDSRPPAQL-----ALSHAGRLLASSTAASVPNTLRL 1226 RL + ES G A + C + P + +L R A L Sbjct: 3363 HFIGRLRH-QESIEGATATLRCELSKAAPVEWRKGRESLRDGDRHSLRQDGA----VCEL 3417 Query: 1227 ELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVI----LAPEAAVPEGAPITVTC- 1281 ++ G D G YSC G+ TS L ++ + L E AV EGA + C Sbjct: 3418 QICGLAVADAGEYSCVC----GEERTSATLTVKALPAKFTEGLRNEEAV-EGATAMLWCE 3472 Query: 1282 ---ADPAAHAPTLYTWYHNGRWL--QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSR 1336 P R++ QEG L A AG Y C R Sbjct: 3473 LSKVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYLCVC------GQER 3526 Query: 1337 PAALQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHDGKVLATSSGVHS 1394 +A + A + ++ AR + AV+QC ++S P E G + Sbjct: 3527 TSATLTIRALPARFIEDVKNQEAREGATAVLQCELNSAAPVE-----------WRKGSET 3575 Query: 1395 LASGTGH-VQVARNALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQVEGARVVAEPG 1452 L G + ++ LQ++ + D Y C + G T L V + G Sbjct: 3576 LRDGDRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAMLTVRALPIKFTEG 3631 Query: 1453 L---DVPEGAALNLSCRL 1467 L + EGA L C L Sbjct: 3632 LRNEEATEGATAVLRCEL 3649 Score = 69.3 bits (168), Expect = 3e-11 Identities = 313/1506 (20%), Positives = 499/1506 (33%), Gaps = 280/1506 (18%) Query: 255 GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYT 304 G TL+C+V A + + W KDG +L + V L + QA + AG Y+ Sbjct: 1457 GASTTLSCEVAQ---AQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYS 1513 Query: 305 CQAENGVGSLVSPPISLHIFMAEVQV-----SPAGPILENQTVTLVCNTPNEAPSDLRYS 359 C+A S +S H+ +AE + PA ++ + T + A + + Sbjct: 1514 CEAG-------SQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATLSCEVAQAQTEVT 1566 Query: 360 WYKNHVLLEDAH---------SHTLRLHLATRADTGFYFCEVQN------VHGSERSGPV 404 WYK+ L + + L + A +AD G Y C+ + +H +E P Sbjct: 1567 WYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHVAE---PK 1623 Query: 405 SVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPR 464 V P + A +AG L C V G + +S+ + Sbjct: 1624 VVFAKEQPAHREVQA----EAGASATLSCEVAQAQTEVTWYKDGKKLSSSS--------K 1671 Query: 465 FSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAA----- 519 + + RL ++ + D+GEY C A G + H IS Sbjct: 1672 VRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQRLSFRLHVAELEPQISERPCRREP 1727 Query: 520 -EVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH---------EGPGSSLLLPAASSTD 569 V E + + L+ L+ A +W +G + +G +L + A D Sbjct: 1728 LVVKEHEDIILTAT--LATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLD 1785 Query: 570 AGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSD 629 + Y CR A G P + + RL L+ G L C + Sbjct: 1786 SAIYSCRV----GAEGQDFPVQVEEVAAK-----FCRL-LEPVCGELGGTVTLACELS-- 1833 Query: 630 PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLC 689 PA +++ R T L G R ++ + + + E+ G Y+C Sbjct: 1834 -PACAEVVW--RCGNTQLRVG----------KRFQMVAEGPVRSLTVLGLRAEDAGEYVC 1880 Query: 690 EASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV 749 E+ + +A + + ++ + +EG EA C VS S WFR+G Sbjct: 1881 ESRDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVVSP----SDVAVVWFRDGA 1936 Query: 750 LWAQGPLETVTLLPVARTDAALYACRILTEAGA------QLSTPVLLSVLYPPDRPKLSA 803 L P E + + + + +L +AG S+ L V P K Sbjct: 1937 LLQ--PSEKFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKL 1994 Query: 804 LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863 + ++ + +RP L LA G V H AE +L + Sbjct: 1995 EPQTVEERSSVTLEVELTRPWPELRWTRNATALAP--GKNVEIH------AEGARHRLVL 2046 Query: 864 RELGLGDSGSYRCEATNVLGSSNTSLFFQVRGA-WVQVSPSPELQEGQAVVLSCQVHTGV 922 +G D G + CE + + L ++R V+ + E +E + Q+ Sbjct: 2047 HNVGFADRGFFGCETPD--DKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQLSHAD 2104 Query: 923 PEGTSYRWYRDGQPLQESTSATL--RFAAITLTQAGAYHCQA-----QAPGSATTSLAAP 975 +G+ W RDG Q+ + L R TLT +G + +A G T++ Sbjct: 2105 VDGS---WTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKAEGVHTSARLVV 2161 Query: 976 ISLHVSYA-PRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034 L VS++ P +TT + L C + S P +R L GV Sbjct: 2162 TELPVSFSRPLQDVVTTEKEKVT-----LECEL-SRPNVDVRWLK---------DGVELR 2206 Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASA---------------- 1078 G + + +A L I+ D+GVY+C+A + AS Sbjct: 2207 AGKT--MAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLA 2264 Query: 1079 -----------SADFDAQAVNVQVWPGATVR--------EGQLVNLTCLVWTTHPAQLTY 1119 +A+ AQ + V+ P VR E L C V A Sbjct: 2265 EDAGEIQFVAENAESRAQ-LRVKELPVTLVRPLRDKIAMEKHRGVLECQV---SRASAQV 2320 Query: 1120 TWYQDGQQRLDA-----------HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV 1168 W++ Q+ + + +V D +Y C G + + + Sbjct: 2321 RWFKGSQELQPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDAGDVKTSAQFF--VEEQS 2378 Query: 1169 LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLEL 1228 + R L+ ++E RPP + L T + LE Sbjct: 2379 ITIVRGLQDVTVMEPAPAWFECETSIPSVRPP---------KWLLGKTVLQAGGNVGLEQ 2429 Query: 1229 RGPQPRDEGFYSCSARS-----PLGQANTSLELRLEGVRVILAPEAAVPEGAPI-TVTCA 1282 G R +CS + +G++ +S L + + V+L G + +V + Sbjct: 2430 EGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPLEPKTGRELQSVVLS 2489 Query: 1283 DPAAHAPTLYTWYHNGRWLQ---------EGPAASLSFLVATRAHAGAYSCQAQDAQGTR 1333 AP WY + L EG A L L A AG Y CQA A + Sbjct: 2490 CDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHSST 2549 Query: 1334 SSRPAALQVLYAPQDAVLSSFRDSRA--RSMAVIQCTVDSEPPAELALSHDGKVLATSSG 1391 A +V V +D+ A A C + E E+ S +G L S Sbjct: 2550 EVTVEAREV------TVTGPLQDAEATEEGWASFSCELSHE-DEEVEWSLNGMPLYNDSF 2602 Query: 1392 VHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEP 1451 G H V ++ R D + A +L +ST RL+V VV Sbjct: 2603 HEISHKGRRHTLVLKSIQRA---------DAGIVRASSL--KVSTSARLEVRVKPVVFLK 2651 Query: 1452 GLD---VPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQ--- 1505 LD E L L C + V W + P F H A + Sbjct: 2652 ALDDLSAEERGTLALQCEVSDPEAHV-------VWRKDGVQLGPSDKYDFLHTAGTRGLV 2704 Query: 1506 --------AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVD 1557 AG+Y C A L V + TM V +L Sbjct: 2705 VHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHESA 2764 Query: 1558 SEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASN 1617 S+P A T +G + V SS A + ++L + PSD GE + S Sbjct: 2765 SDP-AMWT--VGGKTVGSSSRFQATRQGRKYILV--------VREAAPSDAGEVVFSVRG 2813 Query: 1618 VLGSAS 1623 + AS Sbjct: 2814 LTSKAS 2819 Score = 68.9 bits (167), Expect = 4e-11 Identities = 266/1211 (21%), Positives = 410/1211 (33%), Gaps = 218/1211 (18%) Query: 509 NAARLLISPAAEVV----------EGQAVTLSCRSGLSPTPDARFSWYLNGALLH----- 553 ++ARL++S V+ E Q+V LSC P P A WY + L Sbjct: 2458 SSARLVVSDIPVVLTRPLEPKTGRELQSVVLSC--DFRPAPKA-VQWYKDDTPLSPSEKF 2514 Query: 554 ----EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDL 609 EG + L + DAG Y C+A HS++ V R+ T T L Sbjct: 2515 KMSLEGQMAELRILRLMPADAGVYRCQAGSAHSST--------EVTVEAREVTVTGPLQ- 2565 Query: 610 DAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAP 669 DA G +L H+D V SL G + Sbjct: 2566 DAEATEEGWASF-----------SCELSHEDEEVEWSL---NGMPLYNDSFHEISHKGRR 2611 Query: 670 NLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTC 729 + L ++ + + G+ + +A + A+ + GT A L C Sbjct: 2612 HTLVLK--SIQRADAGIVRASSLKVSTSARLEVRVKPVVFLKALDDLSAEERGTLA-LQC 2668 Query: 730 NVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVART-----------DAALYACRILT 778 VS A+ W ++GV GP + L A T DA LY C + + Sbjct: 2669 EVS----DPEAHVVWRKDGV--QLGPSDKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGS 2722 Query: 779 EAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLAT 838 E + V + L+ +L + ++ +G F C + + A++ T Sbjct: 2723 E---ETRARVRVHDLHVGITKRLKTM-EVLEGESCSFECVLSHESASDPAMW-------T 2771 Query: 839 SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV 898 G V S RFQA + L VRE D+G + +S SL + R A + Sbjct: 2772 VGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGEVVFSVRGL--TSKASLIVRERPAAI 2829 Query: 899 QVSPSPE--LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQ---------ESTSATLRF 947 + P + + G+ V L C++ GT W +D + ++ E T A L Sbjct: 2830 -IKPLEDQWVAPGEDVELRCELSRA---GTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVI 2885 Query: 948 AAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVT--LTTLMDTGPGRLGLLLC 1005 +L AG Y C+ +A S SLHV T LT L G + C Sbjct: 2886 RGASLKDAGEYTCEVEASKSTA-------SLHVEEKANCFTEELTNLQVEEKG-TAVFTC 2937 Query: 1006 RVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVY 1065 + + P A + G L+ G + S L TLRL I D Y Sbjct: 2938 KTE-HPAATVTWRKG----LLELRASGKHQPSQEGL-------TLRLTISALEKADSDTY 2985 Query: 1066 ICEASNTLGQASASADFDAQAVNVQV---WPGATVREGQLVNLTCLVWTTHPAQL-TYTW 1121 C+ +GQA + A Q V + V+EG C + PA W Sbjct: 2986 TCD----IGQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSATFRCRI---SPANYEPVHW 3038 Query: 1122 YQDGQ-------QRLDA-----HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVL 1169 + D +DA H + L + ++D+ + G R S + + Sbjct: 3039 FLDKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEAGD----QRASAALRVTEK 3094 Query: 1170 YAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVP---NTLRL 1226 + + LT + G L LV T P + + G+ L S + + +L Sbjct: 3095 PSVFSRELTDATITEGEDLTLVCETSTCDIP--VCWTKDGKTLRGSARCQLSHEGHRAQL 3152 Query: 1227 ELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAA 1286 + G +D G Y C A + + R + L + V EG T+ C + Sbjct: 3153 LITGATLQDSGRYKCEAGGACSSSIVRVHARPVRFQEAL-KDLEVLEGGAATLRCVLSSV 3211 Query: 1287 HAPTLYTWYHN-------GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAA 1339 AP + + +N QEG L +G YSC D + A Sbjct: 3212 AAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSFGD-----QTTSAT 3266 Query: 1340 LQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLAS 1397 L V P + R+ A + A ++C + P E G +L Sbjct: 3267 LTVTALPAQ-FIGKLRNKEATEGATATLRCELSKAAPVE-----------WRKGSETLRD 3314 Query: 1398 GTGHVQVARNAL-RLQVQD---VPAGDDTYVCTAQNLLGSIST-------IGRLQVEGAR 1446 G + A+ LQ++ V A + + VC + S++ IGRL+ + Sbjct: 3315 GDRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFIGRLRHQ--- 3371 Query: 1447 VVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA----EPVPTLAFTHVA 1502 + EGA L C L PV D H+ V L +A Sbjct: 3372 -------ESIEGATATLRCE-LSKAAPVEWRKGRESLRDGDRHSLRQDGAVCELQICGLA 3423 Query: 1503 RAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLA 1562 A AG Y C+ G ++ + P K + E G +L C + +A Sbjct: 3424 VADAGEYSCVC----GEERTSATLTVKALPAKFTEGLRNEEAVEGATAMLWCELSK--VA 3477 Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622 + G P+ + + I L +D GEY+C V G Sbjct: 3478 PVEWRKG--------PENLRDGDRYILRQEGTRCELQICGLAMADAGEYLC----VCGQE 3525 Query: 1623 STSTYFGVRAL 1633 TS +RAL Sbjct: 3526 RTSATLTIRAL 3536 Score = 67.8 bits (164), Expect = 9e-11 Identities = 122/500 (24%), Positives = 189/500 (37%), Gaps = 80/500 (16%) Query: 138 EPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVG 197 EP+V A + + ST C Q + + + ++F+S K VG Sbjct: 1437 EPKV-VFAKEQPVHREVQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSFSS-KVRMEAVG 1494 Query: 198 HLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILP--G 255 L + Q G+ + + S + HL V PK V P+ R + G Sbjct: 1495 CTRRLVV----QQAGQAVAGEYSCEAGSQRLSFHLHVA-EPKAVFAKEQPASREVQAEAG 1549 Query: 256 ELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTC 305 TL+C+V A + + W KDG +L + + V L + +A +DAG Y+C Sbjct: 1550 TSATLSCEVAQ---AQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSC 1606 Query: 306 QAENGVGSLVSPPISLHIFMAEVQV-----SPAGPILENQ---TVTLVCNTPNEAPSDLR 357 +A + +S H+ +AE +V PA ++ + + TL C A + Sbjct: 1607 KAGD-------QRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEV---AQAQTE 1656 Query: 358 YSWYKNHVLLEDAH---------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVV 408 +WYK+ L + + L + A +AD G Y CE G +R +S + Sbjct: 1657 VTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQR---LSFRL 1709 Query: 409 NHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSG-DSDHSPRFSG 467 + L P ++ + LV H ++ ATL + G + S R Sbjct: 1710 HVAELEPQISERPCRREPLVVKEHEDIILT--ATLATPSAATVTWLKDGVEIRRSKRHET 1767 Query: 468 TSGPNSLRLEIRDLEETDSGEYKCSA-TNSLGNATSTLDFHANAARLLISPAAEVVEGQA 526 S ++ L + + DS Y C + A RLL E+ G Sbjct: 1768 ASQGDTHTLTVHGAQVLDSAIYSCRVGAEGQDFPVQVEEVAAKFCRLLEPVCGEL--GGT 1825 Query: 527 VTLSCRSGLSPTPDARFSWYLNGALLH---------EGPGSSLLLPAASSTDAGSYHCRA 577 VTL+C LSP A W L EGP SL + + DAG Y C + Sbjct: 1826 VTLACE--LSPAC-AEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCES 1882 Query: 578 RDGHSASGPSSPAVLTVLYP 597 RD H++ A LTV P Sbjct: 1883 RDDHTS------AQLTVSVP 1896 Score = 58.5 bits (140), Expect = 5e-08 Identities = 219/971 (22%), Positives = 342/971 (35%), Gaps = 172/971 (17%) Query: 172 RLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIH 231 R Q + P RS+T + E G ++ S DH QL+V+ Sbjct: 1853 RFQMVAEGPVRSLTVLGLRAEDAGE------YVCESRDDH---TSAQLTVS--------- 1894 Query: 232 LQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ------- 284 P+ VK + S G T C V+ P+ ++ W +DG LQ Sbjct: 1895 -----VPRVVKFMSGLSTVVAEEGGEATFQCVVS---PSDVAVVWFRDGALLQPSEKFAI 1946 Query: 285 TKTGVLH---LPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQT 341 +++G H + DAG T +AE G S + + + + ++ P + E + Sbjct: 1947 SQSGASHSLTISDLVLEDAGQITVEAE-GASSSAALRVREAPVLFKKKLEPQ-TVEERSS 2004 Query: 342 VTLVCNTPNEAPSDLRYSWY-------KNHVLLEDAHSHTLRLHLATRADTGFYFCEVQN 394 VTL P +LR++ KN + + H L LH AD GF+ CE + Sbjct: 2005 VTLEVELTRPWP-ELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCETPD 2063 Query: 395 VHGSERSGPVSVVVNHPPLTPVLTAFLETQAGL----VGILHCSVVSEPLATLVLSHGGH 450 + ++V + L L A + G V + H V + G Sbjct: 2064 ---DKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQLSHADVDGS------WTRDG- 2113 Query: 451 ILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG--EYKCSATNSLGNATSTLDFHA 508 L G + H GP L + L DSG +K ++ T + Sbjct: 2114 -LRFQQGPTCHL----AVRGPMHT-LTLSGLRPEDSGLMVFKAEGVHTSARLVVT-ELPV 2166 Query: 509 NAARLLISPAAEVV--EGQAVTLSCRSGLSPTPDARFSWYLNG---------ALLHEGPG 557 + +R P +VV E + VTL C P D R W +G A+ +G Sbjct: 2167 SFSR----PLQDVVTTEKEKVTLECELS-RPNVDVR--WLKDGVELRAGKTMAIAAQGAC 2219 Query: 558 SSLLLPAASSTDAGSYHCRARDGHS-ASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGA 616 SL + D G Y C A D S AS T++Y R+ ++ A Sbjct: 2220 RSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIY--RRVLAEDAGEIQFVAENA 2277 Query: 617 GRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCS--------------PR 662 R L RV P ++ L +D++ C + P+ Sbjct: 2278 ESRAQL--RVKELPVTLVRPL-RDKIAMEKHRGVLECQVSRASAQVRWFKGSQELQPGPK 2334 Query: 663 MKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATF---NGQATVLAIAPSHTL 719 ++ ++ I + E+E Y C+A G+ TSA F T++ T+ Sbjct: 2335 YELVSDGLYRKLIISDVHAEDEDTYTCDA----GDVKTSAQFFVEEQSITIVRGLQDVTV 2390 Query: 720 QEGTEANLTCNVSREAAGSPANFSWFRNG-VLWAQGPLE-----TVTLLPVARTDAALYA 773 E A C S + P W VL A G + TV L + RT + + Sbjct: 2391 MEPAPAWFECETSIPSVRPP---KWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTG 2447 Query: 774 CRILTEAGAQLSTPVLLS----VLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLAL 829 T ++ S +++S VL P PK L + + D RP Sbjct: 2448 PVHFTVGKSRSSARLVVSDIPVVLTRPLEPKTGRELQS-------VVLSCDFRPAPKAVQ 2500 Query: 830 FHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSL 889 ++ + P PS +F+ E +L + L D+G YRC+A GS+++S Sbjct: 2501 WYKDDT------PLSPSE-KFKMSLEGQMAELRILRLMPADAGVYRCQA----GSAHSST 2549 Query: 890 FFQVRGAWVQVSPSPELQEGQA-----VVLSCQVHTGVPEGTSYRWYRDGQPLQEST--S 942 V +V+ + LQ+ +A SC++ E W +G PL + Sbjct: 2550 EVTVEAR--EVTVTGPLQDAEATEEGWASFSCELS---HEDEEVEWSLNGMPLYNDSFHE 2604 Query: 943 ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL 1002 + + TL A +++ ++ L V P V L L D G Sbjct: 2605 ISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKP-VVFLKALDDLSAEERGT 2663 Query: 1003 LLCRVD-SDPPAQLRLLHGDRLVASTLQGVG-GPEGSSPRLHVAVAPNTLRLEIHGAMLE 1060 L + + SDP A V GV GP LH A T L +H E Sbjct: 2664 LALQCEVSDPEAH---------VVWRKDGVQLGPSDKYDFLHTA---GTRGLVVHDVSPE 2711 Query: 1061 DEGVYICEASN 1071 D G+Y C + Sbjct: 2712 DAGLYTCHVGS 2722 Score = 57.8 bits (138), Expect = 9e-08 Identities = 79/348 (22%), Positives = 119/348 (34%), Gaps = 82/348 (23%) Query: 1339 ALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASG 1398 A + L P+ V+S +D A + C + P +++ D + +A + G Sbjct: 9 APRFLTRPKAFVVSVGKD------ATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDG 62 Query: 1399 TGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQVEGARVVAEPG----- 1452 + RL + D+ GD YVC A+N +G LQV+ AE Sbjct: 63 --------DLYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLL 114 Query: 1453 ----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQA-- 1506 + V EG+ CR+ G P P +W + RRL P + + A A Sbjct: 115 RPTSIRVREGSEATFRCRVGGSPRPA----VSWSKDGRRLGEPDGPRVRVEELGEASALR 170 Query: 1507 ---------GMYHCLAELPTGAAASAPVML------------------------------ 1527 G Y AE P GAA++A ++ Sbjct: 171 IRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAM 230 Query: 1528 ----RVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPA 1583 PP T T V G L C V EP +LV + Sbjct: 231 RAEGAPASPPSTGTRTCTVTE--GKHARLSCYVTGEPKPETVWKKDGQLVTEGR------ 282 Query: 1584 EPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631 H+ + + I + SD+G Y C+ASN++G +S VR Sbjct: 283 -RHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVR 329 Score = 54.3 bits (129), Expect = 1e-06 Identities = 54/192 (28%), Positives = 78/192 (40%), Gaps = 24/192 (12%) Query: 909 GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST----------SATLRFAAITLTQAGAY 958 G+ V L+C+V TG P+ WY+DG+ +Q S L ++T +G Y Sbjct: 6028 GETVKLACRV-TGTPKPV-ISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQY 6085 Query: 959 HCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLL 1018 C A + ++L + V PR V G C ++ P Q+R Sbjct: 6086 MCFAASAAGNCSTLG---KILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWY 6142 Query: 1019 HGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASA 1078 L+ + G S PR + V L I A ED G+Y CE N LG A A Sbjct: 6143 KDGALLTT---GNKFQTLSEPRSGLLV------LVIRAASKEDLGLYECELVNRLGSARA 6193 Query: 1079 SADFDAQAVNVQ 1090 SA+ Q+ +Q Sbjct: 6194 SAELRIQSPMLQ 6205 Score = 50.4 bits (119), Expect = 1e-05 Identities = 55/222 (24%), Positives = 83/222 (37%), Gaps = 26/222 (11%) Query: 718 TLQEGTEANLTCNVSREAAGSPAN-FSWFRNGVLWAQGPLETVTLLP----------VAR 766 T + G L C V+ G+P SW+++G P + P + Sbjct: 6024 TAELGETVKLACRVT----GTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTG 6079 Query: 767 TDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLAL 826 D+ Y C + AG ST + V PP +G A F CT++ P Sbjct: 6080 VDSGQYMCFAASAAG-NCSTLGKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQ 6138 Query: 827 LALFHGEHLLATSLGPQVPSHGRFQAKAEANS--LKLEVRELGLGDSGSYRCEATNVLGS 884 + + LL T +FQ +E S L L +R D G Y CE N LGS Sbjct: 6139 IRWYKDGALLTTG--------NKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGS 6190 Query: 885 SNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGT 926 + S +++ +Q ++ A V + T VP+ T Sbjct: 6191 ARASAELRIQSPMLQAQEQCHREQLVAAVEVTEQETKVPKKT 6232 Score = 49.3 bits (116), Expect = 3e-05 Identities = 57/198 (28%), Positives = 86/198 (43%), Gaps = 31/198 (15%) Query: 524 GQAVTLSCRSGLSPTPDARFSWYLNGA--------LLHEGPGSS--LLLPAASSTDAGSY 573 G+ V L+CR ++ TP SWY +G +L E P S L+L + + D+G Y Sbjct: 6028 GETVKLACR--VTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQY 6085 Query: 574 HCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPAR 633 C A +A S+ + V PPR F ++ A+ G C ++ P + Sbjct: 6086 MCFAAS--AAGNCSTLGKILVQVPPR---FVNKVR--ASPFVEGEDAQFTCTIEGAPYPQ 6138 Query: 634 LQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASN 693 ++ +KD + T+ G T PR LL + I E+ GLY CE N Sbjct: 6139 IRW-YKDGALLTT---GNKFQTLS--EPRS------GLLVLVIRAASKEDLGLYECELVN 6186 Query: 694 ALGNASTSATFNGQATVL 711 LG+A SA Q+ +L Sbjct: 6187 RLGSARASAELRIQSPML 6204 Score = 46.6 bits (109), Expect = 2e-04 Identities = 49/182 (26%), Positives = 72/182 (39%), Gaps = 23/182 (12%) Query: 1096 TVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ-RLDAHSIP-----------LPNVTVRD 1143 T G+ V L C V T + +WY+DG+ ++D H I L ++T D Sbjct: 6024 TAELGETVKLACRV--TGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVD 6081 Query: 1144 ATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQ 1202 + Y C G L + + V PR + G+ A CT++ P Q Sbjct: 6082 SGQYMCFAASAAGNCSTLGKIL---VQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQ 6138 Query: 1203 LALSHAGRLLASST---AASVPNT--LRLELRGPQPRDEGFYSCSARSPLGQANTSLELR 1257 + G LL + S P + L L +R D G Y C + LG A S ELR Sbjct: 6139 IRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELR 6198 Query: 1258 LE 1259 ++ Sbjct: 6199 IQ 6200 Score = 40.8 bits (94), Expect = 0.011 Identities = 49/186 (26%), Positives = 73/186 (39%), Gaps = 22/186 (11%) Query: 340 QTVTLVCNTPNEAPSDLRYSWYKN---------HVLLEDAH-SHTLRLHLATRADTGFYF 389 +TV L C + SWYK+ H+L+ED S L L T D+G Y Sbjct: 6029 ETVKLACRVTGTPKPVI--SWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYM 6086 Query: 390 CEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGG 449 C + G+ S ++V PP G C++ P + G Sbjct: 6087 CFAASAAGN-CSTLGKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDG 6145 Query: 450 HILASTSGDSDHSPRFSGTSGPNS--LRLEIRDLEETDSGEYKCSATNSLGNATSTLDFH 507 +L T+G+ +F S P S L L IR + D G Y+C N LG+A ++ + Sbjct: 6146 ALL--TTGN-----KFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELR 6198 Query: 508 ANAARL 513 + L Sbjct: 6199 IQSPML 6204 Score = 40.0 bits (92), Expect = 0.019 Identities = 88/430 (20%), Positives = 139/430 (32%), Gaps = 101/430 (23%) Query: 639 KDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEE-------------- 684 +++ V P C G P ++ K LL + H + E++ Sbjct: 5133 QNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPA 5192 Query: 685 --GLYLCEASNALGNASTSATFNGQAT-----VLAIAP------------SHTLQEGTEA 725 G+Y C A N++G +ST A T A A S QEGTE+ Sbjct: 5193 DMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTES 5252 Query: 726 NLT----------------------CNVSREAAGSPA-NFSWFRNGV---------LWAQ 753 + G PA WF++G + + Sbjct: 5253 TTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDK 5312 Query: 754 GPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQ---- 809 L T+ ++ V R D+ YA I GA S+ LL + PD P+ D+ + Sbjct: 5313 KILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLL--VRGPDEPEEKPASDVHEQLVP 5370 Query: 810 --------------GHMALFICTVDSRPLALLALFHGEHLLATS-LGPQVPSHGRFQAKA 854 G F V+ RP+ + E +GP P + + Sbjct: 5371 PRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPG---YTVAS 5427 Query: 855 EANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVL 914 A L + ++G G+Y C A+N G + S V G P E QE L Sbjct: 5428 SAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGL-----PKVEEQEKVKEAL 5482 Query: 915 SCQVHTGVPEGTSYRWYR-------DGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGS 967 G + S + GQ +E +A ++L + G + Sbjct: 5483 ISTFLQGTTQAISAQGLETASFADLGGQRKEEPLAAKEALGHLSLAEVGTEEFLQKLTSQ 5542 Query: 968 ATTSLAAPIS 977 T ++A I+ Sbjct: 5543 ITEMVSAKIT 5552 Score = 40.0 bits (92), Expect = 0.019 Identities = 42/188 (22%), Positives = 70/188 (37%), Gaps = 27/188 (14%) Query: 1458 GAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVP----------TLAFTHVARAQAG 1507 G + L+CR+ G P PV +W+ + + + +P L + +G Sbjct: 6028 GETVKLACRVTGTPKPV----ISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSG 6083 Query: 1508 MYHCLAELPTGAAASAPVMLRVLYPPKTPTMM---VFVEPEGGLRGILDCRVDSEPLASL 1564 Y C A G ++ +L V PP+ + FVE E C ++ P + Sbjct: 6084 QYMCFAASAAGNCSTLGKIL-VQVPPRFVNKVRASPFVEGEDAQ---FTCTIEGAPYPQI 6139 Query: 1565 TLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSAST 1624 + L+ + +EP +L + I A D G Y C N LGSA Sbjct: 6140 RWYKDGALLTTGNKFQTLSEPRSGLLV------LVIRAASKEDLGLYECELVNRLGSARA 6193 Query: 1625 STYFGVRA 1632 S +++ Sbjct: 6194 SAELRIQS 6201 Score = 36.2 bits (82), Expect = 0.28 Identities = 42/191 (21%), Positives = 75/191 (39%), Gaps = 25/191 (13%) Query: 1274 GAPITVTCADPAAHAPTLYTWYHNGRWLQ--------EGPAASLSFLV--ATRAHAGAYS 1323 G + + C P + +WY +G+ +Q E P S + ++ T +G Y Sbjct: 6028 GETVKLACRVTGTPKPVI-SWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYM 6086 Query: 1324 CQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSR--ARSMAVIQCTVDSEPPAELALSH 1381 C A A G S+ ++L ++ R S A CT++ P ++ Sbjct: 6087 CFAASAAGNCSTLG---KILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYK 6143 Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD--TYVCTAQNLLGSISTIGR 1439 DG +L T + +L+ R+ L + V + +D Y C N LGS Sbjct: 6144 DGALLTTGNKFQTLSE-------PRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAE 6196 Query: 1440 LQVEGARVVAE 1450 L+++ + A+ Sbjct: 6197 LRIQSPMLQAQ 6207 Score = 34.3 bits (77), Expect = 1.1 Identities = 74/336 (22%), Positives = 111/336 (33%), Gaps = 73/336 (21%) Query: 520 EVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP----------GSSLLLPAASSTD 569 EV +G V+ C P P R W+ +G LL E G L++ A D Sbjct: 5136 EVQDGYPVSFDCVVTGQPMPSVR--WFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPAD 5193 Query: 570 AGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRV--- 626 G Y C A + S S+ A L V + T D + + +G L R Sbjct: 5194 MGVYRCLAENSMGVS--STKAELRV--DLTSTDYDTAADATESSSYFSAQGYLSSREQEG 5249 Query: 627 ------DSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRM---------------KV 665 + P ++ L +V + + G +PR+ ++ Sbjct: 5250 TESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRM 5309 Query: 666 TKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATF-----------NGQATVLAIA 714 T L +EI + E+ G Y SNA+G A +SA + Sbjct: 5310 TDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLV 5369 Query: 715 PSHTLQEGTE------ANLTCNVSREAAGSPANFSWFR----NGVLW-----------AQ 753 P L+ T +++T +V E P W R GVLW + Sbjct: 5370 PPRMLERFTPKKVKKGSSITFSVKVEGRPVP-TVHWLREEAERGVLWIGPDTPGYTVASS 5428 Query: 754 GPLETVTLLPVARTDAALYACRILTEAGAQLSTPVL 789 ++ LL V R Y C AG L + L Sbjct: 5429 AQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASL 5464 Score = 33.5 bits (75), Expect = 1.8 Identities = 74/337 (21%), Positives = 114/337 (33%), Gaps = 79/337 (23%) Query: 255 GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAA------------WSDAGV 302 G+ + L C V S A +WLKDGV L T H+ Q +DAG Sbjct: 4912 GDALRLECVVASK--ADVRARWLKDGVEL-TDGRHHHIDQLGDGTCSLLITGLDRADAGC 4968 Query: 303 YTCQAENGVGSLV-SPPISLHIFMAEVQVSPAG-----------------------PILE 338 YTCQ N G + S + + +E + S G + + Sbjct: 4969 YTCQVSNKFGQVTHSACVVVSGSESEAESSSGGELDDAFRRAARRLHRLFRTKSPAEVSD 5028 Query: 339 NQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRA-----------DTGF 387 + P E + Y+ ED H +R T A T Sbjct: 5029 EELFLSADEGPAEPEEPADWQTYR-----EDEHFICIRFEALTEARQAVTRFQEMFATLG 5083 Query: 388 YFCEVQNVHGSERSGPVSV-------VVNHPPLTPVLTA-----FL------ETQAGLVG 429 E++ V R + + VV PL +LT+ FL E Q G Sbjct: 5084 IGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPV 5143 Query: 430 ILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEY 489 C V +P+ ++ G +L + DH G + +L I + D G Y Sbjct: 5144 SFDCVVTGQPMPSVRWFKDGKLLE----EDDHYMINEDQQGGH--QLIITAVVPADMGVY 5197 Query: 490 KCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQA 526 +C A NS+G +++ + + AA+ E + Sbjct: 5198 RCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSS 5234 Score = 33.1 bits (74), Expect = 2.4 Identities = 30/94 (31%), Positives = 44/94 (46%), Gaps = 21/94 (22%) Query: 234 VKYAPKGV-KILLSPSGRNILPGELVTLTCQVNSS-YPAVSSIKWLKDGVRLQT------ 285 V+ P+ V K+ SP + GE TC + + YP I+W KDG L T Sbjct: 6104 VQVPPRFVNKVRASP----FVEGEDAQFTCTIEGAPYP---QIRWYKDGALLTTGNKFQT 6156 Query: 286 ----KTG--VLHLPQAAWSDAGVYTCQAENGVGS 313 ++G VL + A+ D G+Y C+ N +GS Sbjct: 6157 LSEPRSGLLVLVIRAASKEDLGLYECELVNRLGS 6190 >gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF isoform b [Homo sapiens] Length = 7968 Score = 119 bits (297), Expect = 3e-26 Identities = 374/1644 (22%), Positives = 572/1644 (34%), Gaps = 315/1644 (19%) Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159 L++ D+ PED+G Y E V V +T+ + +E+LEG F Sbjct: 2703 LVVHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKT------MEVLEGESCSFE 2756 Query: 160 CSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHM-AMSWQDHGRILRCQ 218 C + + G+ +S +F+ T G L + + D G ++ Sbjct: 2757 CVLSHESASDPAMWTVGGK-----TVGSSSRFQATRQGRKYILVVREAAPSDAGEVV--- 2808 Query: 219 LSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLK 278 SV S+ L V+ P I+ + + PGE V L C+++ A + + WLK Sbjct: 2809 FSVRG--LTSKASLIVRERP--AAIIKPLEDQWVAPGEDVELRCELSR---AGTPVHWLK 2861 Query: 279 D--GVRLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHI----- 323 D +R K V L + A+ DAG YTC+ E + SLH+ Sbjct: 2862 DRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKST-----ASLHVEEKAN 2916 Query: 324 ----FMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH------ 373 + +QV G T C T + A + +W K + L + H Sbjct: 2917 CFTEELTNLQVEEKG------TAVFTCKTEHPAAT---VTWRKGLLELRASGKHQPSQEG 2967 Query: 374 -TLRLHLAT--RADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGI 430 TLRL ++ +AD+ Y C++ G +S +V ++ Q G Sbjct: 2968 LTLRLTISALEKADSDTYTCDI----GQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSAT 3023 Query: 431 LHCSVVS---EPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487 C + EP+ + H A+ + D P G + L L R L DSG Sbjct: 3024 FRCRISPANYEPVHWFLDKTPLH--ANELNEIDAQP-----GGYHVLTL--RQLALKDSG 3074 Query: 488 EYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYL 547 A + +A + + ++ A + EG+ +TL C + T D W Sbjct: 3075 TIYFEAGDQRASAALRVTEKPSVFSRELTDAT-ITEGEDLTLVCETS---TCDIPVCWTK 3130 Query: 548 NGALL---------HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598 +G L HEG + LL+ A+ D+G Y C A G S +++ V Sbjct: 3131 DGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKC------EAGGACSSSIVRV--HA 3182 Query: 599 RQPTFTTRL-DLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCG 657 R F L DL+ GA L C V S A ++ + + V+ Sbjct: 3183 RPVRFQEALKDLEVLEGGA---ATLRC-VLSSVAAPVKWCYGNNVLRP------------ 3226 Query: 658 GCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNG---QATVLAIA 714 + + + +L + + N ++ G Y C + G+ +TSAT A + Sbjct: 3227 --GDKYSLRQEGAMLELVVRNLRPQDSGRYSC----SFGDQTTSATLTVTALPAQFIGKL 3280 Query: 715 PSHTLQEGTEANLTCNVSREAAGSPANFS-WFRNG---VLWAQGPLETVTLLPVARTDAA 770 + EG A L C +S+ A S R+G L G + + + +A DAA Sbjct: 3281 RNKEATEGATATLRCELSKAAPVEWRKGSETLRDGDRYCLRQDGAMCELQIRGLAMVDAA 3340 Query: 771 LYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALF 830 Y+C G + ++ L P + +G A C + A + Sbjct: 3341 EYSC----VCGEERTSASLTIRPMPAHFIGRLRHQESIEGATATLRCELSK--AAPVEWR 3394 Query: 831 HGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLF 890 G L R + + +L++ L + D+G Y C V G TS Sbjct: 3395 KGRESLRDG--------DRHSLRQDGAVCELQICGLAVADAGEYSC----VCGEERTSAT 3442 Query: 891 FQVR---GAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRW------YRDGQPL---Q 938 V+ + + + E EG +L C++ P W RDG Q Sbjct: 3443 LTVKALPAKFTEGLRNEEAVEGATAMLWCELSKVAP----VEWRKGPENLRDGDRYILRQ 3498 Query: 939 ESTSATLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP 997 E T L+ + + AG Y C Q SAT ++ A R + + Sbjct: 3499 EGTRCELQICGLAMADAGEYLCVCGQERTSATLTIRA-------LPARFIEDVKNQEARE 3551 Query: 998 GRLGLLLCRVDSDPPAQLR-----LLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRL 1052 G +L C ++S P + R L GDR +L+ G L Sbjct: 3552 GATAVLQCELNSAAPVEWRKGSETLRDGDRY---SLRQDG---------------TKCEL 3593 Query: 1053 EIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG---ATVREGQLVNLTCLV 1109 +I G + D G Y C GQ SA +A+ ++ G EG L C + Sbjct: 3594 QIRGLAMADTGEYSC----VCGQERTSAMLTVRALPIKFTEGLRNEEATEGATAVLRCEL 3649 Query: 1110 WTTHPAQLTYTWYQDGQQRL---DAHS---------IPLPNVTVRDATSYRCGVGPPGRA 1157 P + W++ G + L D HS + + + DA Y C G + Sbjct: 3650 SKMAPVE----WWK-GHETLRDGDRHSLRQDGARCELQIRGLVAEDAGEYLCMCGKERTS 3704 Query: 1158 PRLS-RPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASST 1216 L+ R + + RN E+ G A + C + P + H L Sbjct: 3705 AMLTVRAMPSKFIEGLRN------EEATEGDTATLWCELSKAAPVEWRKGH--ETLRDGD 3756 Query: 1217 AASV---PNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEA---A 1270 S+ + L++RG D G YSC GQ TS L + + + Sbjct: 3757 RHSLRQDGSRCELQIRGLAVVDAGEYSCVC----GQERTSATLTVRALPARFIEDVKNQE 3812 Query: 1271 VPEGAPITVTC----ADPAAHAPTLYTWYHNGRW--LQEGPAASLSFLVATRAHAGAYSC 1324 EGA + C A P T R+ Q+G L + A G YSC Sbjct: 3813 AREGATAVLQCELSKAAPVEWRKGSETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSC 3872 Query: 1325 QAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHD 1382 R +A + APQ + +A S A +QC + SEP A Sbjct: 3873 VC------GQERTSATLTVRAPQPVFREPLQSLQAEEGSTATLQCEL-SEPTA------- 3918 Query: 1383 GKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQ 1441 V+ + G+ A+G ++ L +QD+ D Y CT GS +T L Sbjct: 3919 -TVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTC----GSQATSATLT 3973 Query: 1442 VEGARVVAEPGL---DVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP------ 1492 V A V L +V EG +L C L V W L P Sbjct: 3974 VTAAPVRFLRELQHQEVDEGGTAHLCCELSRAGASVE-------WRKGSLQLFPCAKYQM 4026 Query: 1493 -----VPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGG 1547 L V + AG Y C TG S + + PK T + +E E G Sbjct: 4027 VQDGAAAELLVRGVEQEDAGDYTC----DTGHTQSMASLSVRVPRPKFKTRLQSLEQETG 4082 Query: 1548 LRGILDCRV-DSEPLA-------SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVD 1599 L C++ D+E A + LH G + S QGA E IH Sbjct: 4083 DIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRS--QGATRELLIH----------- 4129 Query: 1600 IEALRPSDQGEYICSASNVLGSAS 1623 L D GEY C +AS Sbjct: 4130 --QLEAKDTGEYACVTGGQKTAAS 4151 Score = 108 bits (269), Expect = 6e-23 Identities = 242/1165 (20%), Positives = 397/1165 (34%), Gaps = 237/1165 (20%) Query: 255 GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYT 304 G L+C+V A + + W KDG +L + + V L LPQA +DAG Y+ Sbjct: 1089 GASAMLSCEVAQ---AQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYS 1145 Query: 305 CQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTV---------TLVCNTPNEAPSD 355 C+A +S H+ + E P G + Q+V T + A Sbjct: 1146 CEAG-------GQRVSFHLHITE----PKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQ 1194 Query: 356 LRYSWYKNHVLLEDAHSHTLRLHLATR---------ADTGFYFCEVQNVHGSER---SGP 403 +WYK+ L + + + TR AD G Y CE S + + P Sbjct: 1195 TEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEP 1254 Query: 404 VSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP 463 +V ++ + T+AG L C V G + +S+ Sbjct: 1255 KAVFAKE----QLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSS-------- 1302 Query: 464 RFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN--------AARLLI 515 + + +L ++ + D+GEY C A L FH + A L Sbjct: 1303 KVRIEAAGCMRQLVVQQAGQADAGEYTCEA------GGQRLSFHLDVSEPKAVFAKEQLA 1356 Query: 516 SPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHE---------GPGSSLLLPAAS 566 + G TLSC + T +WY +G L G L++ A Sbjct: 1357 HRKVQAEAGAIATLSCEVAQAQT---EVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQAC 1413 Query: 567 STDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRV 626 D G Y C A G S A V++ QP A AG L C V Sbjct: 1414 QADTGEYSCEA-GGQRLSFSLDVAEPKVVFAKEQPVHR------EVQAQAGASTTLSCEV 1466 Query: 627 DSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGL 686 A+ +++ S S GC+ R+ V +A + G Sbjct: 1467 ---AQAQTEVMWYKDGKKLSFSSKVRMEAV-GCTRRLVVQQAGQAV-----------AGE 1511 Query: 687 YLCEASNA-----LGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPAN 741 Y CEA + L A A F A + + GT A L+C E A + Sbjct: 1512 YSCEAGSQRLSFHLHVAEPKAVF---AKEQPASREVQAEAGTSATLSC----EVAQAQTE 1564 Query: 742 FSWFRNGV---------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQ-------LS 785 +W+++G + A G + + + DA Y+C+ AG Q ++ Sbjct: 1565 VTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCK----AGDQRLSFHLHVA 1620 Query: 786 TPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVP 845 P ++ P ++ A G A C V + G+ L ++S Sbjct: 1621 EPKVVFAKEQPAHREVQA----EAGASATLSCEVAQAQTEVTWYKDGKKLSSSS------ 1670 Query: 846 SHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSP- 904 + + +A + +L V++ G D+G Y CEA G S V Q+S P Sbjct: 1671 ---KVRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQRLSFRLHVAELEPQISERPC 1723 Query: 905 -----ELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQES---------TSATLRFAAI 950 ++E + ++L+ + T P + W +DG ++ S + TL Sbjct: 1724 RREPLVVKEHEDIILTATLAT--PSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGA 1781 Query: 951 TLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSD 1010 + + Y C+ A G V L++ G LG + Sbjct: 1782 QVLDSAIYSCRVGAEGQ---------DFPVQVEEVAAKFCRLLEPVCGELGGTVTLACEL 1832 Query: 1011 PPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLR-LEIHGAMLEDEGVYICEA 1069 PA A + G + + VA +R L + G ED G Y+CE+ Sbjct: 1833 SPA----------CAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCES 1882 Query: 1070 SNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDG---- 1125 + A + + EG C+V P+ + W++DG Sbjct: 1883 RDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVV---SPSDVAVVWFRDGALLQ 1939 Query: 1126 -------QQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLT 1178 Q +HS+ + ++ + DA A S L V AP + Sbjct: 1940 PSEKFAISQSGASHSLTISDLVLEDAGQITV------EAEGASSSAALRVREAPVLFKKK 1993 Query: 1179 YLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPR---- 1234 ++ + ++ L +RP +L R ++TA + + + G + R Sbjct: 1994 LEPQTVEERSSVTLEVELTRPWPEL------RWTRNATALAPGKNVEIHAEGARHRLVLH 2047 Query: 1235 -----DEGFYSCSARSPLGQANTSLELR----LEGVRVILAPEAAVPEGAPITVTCADPA 1285 D GF+ C QA ++E+R + G++ + A E T T Sbjct: 2048 NVGFADRGFFGCETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQG-------TATMEVQL 2100 Query: 1286 AHAPTLYTWYHNGRWLQEGPAASLS 1310 +HA +W +G Q+GP L+ Sbjct: 2101 SHADVDGSWTRDGLRFQQGPTCHLA 2125 Score = 107 bits (268), Expect = 8e-23 Identities = 282/1306 (21%), Positives = 449/1306 (34%), Gaps = 223/1306 (17%) Query: 441 ATLVLSHGGHILASTSGDSDHSP-----RFSGTSGPNSLRLEIRDLEETDSGEYKCSATN 495 ATL G+ S + D P RF + RL I DL DSG+Y C A N Sbjct: 27 ATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARN 86 Query: 496 SLGNATSTLDFHANAAR---------LLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWY 546 ++G A + + +A LL + V EG T CR G SP P SW Sbjct: 87 AIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRP--AVSWS 144 Query: 547 LNGALLHE-----------GPGSSLLLPAASSTDAGSYHCRAR--------------DGH 581 +G L E G S+L + AA D G+Y RA D Sbjct: 145 KDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSD 204 Query: 582 SASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDR 641 +A S P T + + A A G C V ARL Sbjct: 205 AADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGE 264 Query: 642 VVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTS 701 ++ G G + N + ++I + GLY C ASN +G +S Sbjct: 265 PKPETVWKKDGQLVTEGRRHVVYEDAQENFV-LKILFCKQSDRGLYTCTASNLVGQTYSS 323 Query: 702 ATFNGQATVLAI---APSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV-LWA----- 752 + + ++E A C V + + + +WF+ LWA Sbjct: 324 VLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPSTEA----AWFKEETRLWASAKYG 379 Query: 753 ---QGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQ 809 +G +T+ V+ D A+Y C T G++ + + P+ +A + Sbjct: 380 IEEEGTERRLTVRNVSADDDAVYICE--TPEGSRTVAELAVQGNLLRKLPRKTA---VRV 434 Query: 810 GHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869 G A+F C + P+ + + +V + GR AE L + + L Sbjct: 435 GDTAMF-CVELAVPVGPVHWLRNQE--------EVVAGGRVAISAEGTRHTLTISQCCLE 485 Query: 870 DSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGV------- 922 D G + + G TS F V P LQ V+ ++ + V Sbjct: 486 DVG----QVAFMAGDCQTSTQF-----CVSAPRKPPLQPPVDPVVKARMESSVILSWSPP 536 Query: 923 PEGT----------------SYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPG 966 P G +Y W R + AT + + G + + A Sbjct: 537 PHGERPVTIDGYLVEKKKLGTYTWIRCH---EAEWVATPELTVADVAEEGNFQFRVSALN 593 Query: 967 SATTS--LAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVD-SDPPAQLRLLHGDRL 1023 S S L P ++H+ AP+ T L G + VD + A L G L Sbjct: 594 SFGQSPYLEFPGTVHL--APKLAVRTPLKAVQAVEGGEVTFSVDLTVASAGEWFLDGQAL 651 Query: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFD 1083 AS++ E R + + +HGA L+ ++ + + A Sbjct: 652 KASSVY-----EIHCDRTRHTLTIREVPASLHGAQLK----FVANGIESSIRMEVRA--- 699 Query: 1084 AQAVNVQVWPGATVRE--GQLVNLTCLVWTTHPAQLTYTWYQDG-----------QQRLD 1130 A + P A RE +L L+ TW +DG Q Sbjct: 700 APGLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAG 759 Query: 1131 AHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVL--YAPRNLRLTYLLESHGGQL 1188 + + +V DA Y C R R++ +++ L + +++ + + GG Sbjct: 760 RRVLLVRDVARDDAGLYEC----VSRGGRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPA 815 Query: 1189 ALVLCTVDSRPPAQ-----LALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSA 1243 T ++ + L H+G V RL +DEG YSC Sbjct: 816 QFECETSEAHVHVHWYKDGMELGHSGERFLQE---DVGTRHRLVAATVTRQDEGTYSCR- 871 Query: 1244 RSPLGQANTSLELRLEGVRVILAPE------AAVPEGAPITVTCADPAAHAPTLYTWYHN 1297 +G+ + LR+ +V+ A E GA T++C A A T TWY + Sbjct: 872 ---VGEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSC--EVAQAQTEVTWYKD 926 Query: 1298 GRWLQEGPAASLSFLVATR---------AHAGAYSCQAQDAQGTRSSRPAALQVLYAPQD 1348 G+ L + TR A AG YSC+A + + +V++A +D Sbjct: 927 GKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFA-KD 985 Query: 1349 AVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNA 1408 V S + A + A + C V ++ E+ DGK L++S VH A G R Sbjct: 986 QVAHSEVQAEAGASATLSCEV-AQAQTEVMWYKDGKKLSSSLKVHVEAKG-----CRRRL 1039 Query: 1409 LRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV------AEPGLDVPEGAALN 1462 + Q AGD Y C A+ S RL + +++ + GA+ Sbjct: 1040 VVQQAGKTDAGD--YSCEARGQRVSF----RLHITEPKMMFAKEQSVHNEVQAEAGASAM 1093 Query: 1463 LSCRLLGGPGPVGNSTFAWFWNDRRLHAEP---------VPTLAFTHVARAQAGMYHCLA 1513 LSC + V W+ + ++L + L +A AG Y C A Sbjct: 1094 LSCEVAQAQTEV-----TWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEA 1148 Query: 1514 ELPTGAAASAPVMLRVLYP----PKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLG 1569 L + P K ++ V+ E G +L C V ++P +T + Sbjct: 1149 -----GGQRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEV-AQPQTEVTWYKD 1202 Query: 1570 SRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSA 1615 + ++SS + + R+ ++ + +D GEY C A Sbjct: 1203 GKKLSSSS--------KVRMEVKGCTRRLVVQQVGKADAGEYSCEA 1240 Score = 106 bits (264), Expect = 2e-22 Identities = 312/1484 (21%), Positives = 520/1484 (35%), Gaps = 255/1484 (17%) Query: 256 ELVTLTCQVNSSYPAVSSIKWLKDGVRL--QTKTGV--------LHLPQAAWSDAGVYTC 305 E T C+V P+ + W K+ RL K G+ L + + D VY C Sbjct: 348 ESATFLCEVPQ--PSTEAA-WFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYIC 404 Query: 306 QAENGVGSLVSPPISLHI-----------------FMAEVQVSPAGPI--LENQTVTLVC 346 + G ++ + ++ F E+ V P GP+ L NQ + Sbjct: 405 ETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAV-PVGPVHWLRNQEEVVAG 463 Query: 347 NTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSV 406 + R++ + LED +A T FC + R P+ Sbjct: 464 GRVAISAEGTRHTLTISQCCLEDVGQVAF---MAGDCQTSTQFCV-----SAPRKPPLQ- 514 Query: 407 VVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466 PP+ PV+ A +E+ L S P ++ G+++ + R Sbjct: 515 ----PPVDPVVKARMESSVIL------SWSPPPHGERPVTIDGYLVEKKKLGTYTWIRCH 564 Query: 467 GTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN---AARLLISP---AAE 520 + L + D+ E + +++ SA NS G + L+F A +L + A + Sbjct: 565 EAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPY-LEFPGTVHLAPKLAVRTPLKAVQ 623 Query: 521 VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDG 580 VEG VT S + T + W+L+G L ++ HC R Sbjct: 624 AVEGGEVTFS----VDLTVASAGEWFLDGQAL-------------KASSVYEIHCD-RTR 665 Query: 581 HSASGPSSPAVL---TVLYPPRQPTFTTRLDLDAAG--------AGAGRRGLLLCRVDSD 629 H+ + PA L + + + R+++ AA A A R +L R+ + Sbjct: 666 HTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAARE--VLARLHEE 723 Query: 630 PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLC 689 +L D+ A + G + G P+ +V + + + + ++ GLY C Sbjct: 724 AQLLAEL--SDQAAAVTWLKDGRTLSPG---PKYEVQASAGRRVLLVRDVARDDAGLYEC 778 Query: 690 EASNALGNASTSATFNGQATVLAIAPSHTLQE---GTEANLTCNVSREAAGSPANFSWFR 746 + G + + G A L + + + G A C S + + W++ Sbjct: 779 VSRG--GRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPAQFECETSE----AHVHVHWYK 832 Query: 747 NGVLWAQ----------GPLETVTLLPVARTDAALYACRILTEA---GAQLSTPVLLSVL 793 +G+ G + V R D Y+CR+ ++ ++S P ++ Sbjct: 833 DGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKVVFAK 892 Query: 794 YPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAK 853 R KL A G A C V + G+ L ++S + + Sbjct: 893 EQLARRKLQA----EAGASATLSCEVAQAQTEVTWYKDGKKLSSSS---------KVCME 939 Query: 854 AEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV-----QVSPSP-ELQ 907 A + +L V++ G D+G Y CEA G S V+ V QV+ S + + Sbjct: 940 ATGCTRRLVVQQAGQADAGEYSCEA----GGQRLSFHLDVKEPKVVFAKDQVAHSEVQAE 995 Query: 908 EGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSA---------TLRFAAITLTQAGAY 958 G + LSC+V T WY+DG+ L S L T AG Y Sbjct: 996 AGASATLSCEV---AQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDY 1052 Query: 959 HCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLL 1018 C+A+ S I+ + ++ + G +L C V Sbjct: 1053 SCEAR---GQRVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQTEVTWYK 1109 Query: 1019 HGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA-----SNTL 1073 G +L SS ++ + V T RL + A D G Y CEA S L Sbjct: 1110 DGKKL------------SSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSFHL 1157 Query: 1074 GQASASADF-DAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH 1132 F Q+V+ +V A G L+C V Q TWY+DG++ + Sbjct: 1158 HITEPKGVFAKEQSVHNEVQAEA----GTTAMLSCEV---AQPQTEVTWYKDGKKLSSSS 1210 Query: 1133 SIPL-----------PNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLL 1181 + + V DA Y C G G+ IT + + + Sbjct: 1211 KVRMEVKGCTRRLVVQQVGKADAGEYSCEAG--GQRVSFQLHITEPKAVFAKEQLVHNEV 1268 Query: 1182 ESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT---LRLELRGPQPRDEGF 1238 + G A + C V ++ ++ G+ L+SS+ + +L ++ D G Sbjct: 1269 RTEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGE 1327 Query: 1239 YSCSARSPLGQANTSLELRLEGVRVILAPE------AAVPEGAPITVTCADPAAHAPTLY 1292 Y+C A G S L + + + A E GA T++C A A T Sbjct: 1328 YTCEA----GGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSC--EVAQAQTEV 1381 Query: 1293 TWYHNGRWLQEGPAASLSFLVATR---------AHAGAYSCQAQDAQGTRSSRPAALQVL 1343 TWY +G+ L + + TR A G YSC+A + + S A +V+ Sbjct: 1382 TWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVV 1441 Query: 1344 YAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403 +A + V + ++A + + C V ++ E+ DGK L+ SS V A G Sbjct: 1442 FAKEQPVHREVQ-AQAGASTTLSCEV-AQAQTEVMWYKDGKKLSFSSKVRMEAVG----- 1494 Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNL 1463 R + Q AG+ + +Q L + V A + G + L Sbjct: 1495 CTRRLVVQQAGQAVAGEYSCEAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATL 1554 Query: 1464 SCRLLGGPGPVGNSTFAWFWNDRRLHAEP---------VPTLAFTHVARAQAGMYHCLA- 1513 SC + V W+ + ++L + L +A AG Y C A Sbjct: 1555 SCEVAQAQTEV-----TWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAG 1609 Query: 1514 --ELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSR 1571 L + P +V++ + P V+ E G L C V G + Sbjct: 1610 DQRLSFHLHVAEP---KVVFAKEQPAHRE-VQAEAGASATLSCEVAQAQTEVTWYKDGKK 1665 Query: 1572 LVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSA 1615 L +SS+ + V A R+ ++ +D GEY C A Sbjct: 1666 LSSSSK---------VRVEAVGCTRRLVVQQAGQADAGEYSCEA 1700 Score = 104 bits (260), Expect = 6e-22 Identities = 291/1322 (22%), Positives = 444/1322 (33%), Gaps = 219/1322 (16%) Query: 94 EHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEG 153 E + L+++ +D+G Y E S+ V+ TEE L Sbjct: 2877 EGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEE------------LTN 2924 Query: 154 TEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFN--------SQKFEPTGVGHLETLHMA 205 +V+ + + C E PA +VT+ S K +P+ G L ++ Sbjct: 2925 LQVEEKGTAVFTCKTEH---------PAATVTWRKGLLELRASGKHQPSQEGLTLRLTIS 2975 Query: 206 MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVN 265 + C + A RAQ + + V I+ ++ G T C+++ Sbjct: 2976 ALEKADSDTYTCDIGQAQSRAQLLVQ------GRRVHIIEDLEDVDVQEGSSATFRCRIS 3029 Query: 266 SSYPAVSSIKWLKDGVRLQTKT-----------GVLHLPQAAWSDAG-VYTCQAENGVGS 313 + + W D L VL L Q A D+G +Y + + Sbjct: 3030 PAN--YEPVHWFLDKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEAGDQRASA 3087 Query: 314 LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLE----- 368 + +F E+ + I E + +TLVC T + D+ W K+ L Sbjct: 3088 ALRVTEKPSVFSRELTDAT---ITEGEDLTLVCET---STCDIPVCWTKDGKTLRGSARC 3141 Query: 369 ----DAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQ 424 + H L + AT D+G Y CE G S + V P LE Sbjct: 3142 QLSHEGHRAQLLITGATLQDSGRYKCEA----GGACSSSIVRVHARPVRFQEALKDLEVL 3197 Query: 425 AGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEET 484 G L C V+S A + +G ++L GD +S R G L L +R+L Sbjct: 3198 EGGAATLRC-VLSSVAAPVKWCYGNNVLRP--GDK-YSLRQEGAM----LELVVRNLRPQ 3249 Query: 485 DSGEYKCSATNSLGNATSTLDFHANAARLLIS-PAAEVVEGQAVTLSCR-SGLSPTPDAR 542 DSG Y CS + +AT T+ A A+ + E EG TL C S +P + Sbjct: 3250 DSGRYSCSFGDQTTSATLTVT--ALPAQFIGKLRNKEATEGATATLRCELSKAAPVEWRK 3307 Query: 543 FSWYLNG----ALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598 S L L +G L + + DA Y C + ++ A LT+ P Sbjct: 3308 GSETLRDGDRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTS------ASLTI--RP 3359 Query: 599 RQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGG 658 F RL + GA L C + P R SL G Sbjct: 3360 MPAHFIGRLRHQESIEGA--TATLRCELSKAAPVEW------RKGRESLRDG-------- 3403 Query: 659 CSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAP--- 715 R + + + ++I + + G Y C G TSAT +A Sbjct: 3404 --DRHSLRQDGAVCELQICGLAVADAGEYSC----VCGEERTSATLTVKALPAKFTEGLR 3457 Query: 716 SHTLQEGTEANLTCNVSR----EAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAAL 771 + EG A L C +S+ E P N +L +G + + +A DA Sbjct: 3458 NEEAVEGATAMLWCELSKVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGE 3517 Query: 772 YACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFH 831 Y C E + T L + D A +G A+ C ++S A + Sbjct: 3518 YLCVCGQERTSATLTIRALPARFIEDVKNQEA----REGATAVLQCELNS--AAPVEWRK 3571 Query: 832 GEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFF 891 G L R+ + + +L++R L + D+G Y C V G TS Sbjct: 3572 GSETLRDG--------DRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAML 3619 Query: 892 QVRGAWVQVSP---SPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL---------QE 939 VR ++ + + E EG VL C++ P W++ + L Q+ Sbjct: 3620 TVRALPIKFTEGLRNEEATEGATAVLRCELSKMAP----VEWWKGHETLRDGDRHSLRQD 3675 Query: 940 STSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGR 999 L+ + AG Y C G TS + S + + + G Sbjct: 3676 GARCELQIRGLVAEDAGEYLCMC---GKERTSAMLTVRAMPS---KFIEGLRNEEATEGD 3729 Query: 1000 LGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAML 1059 L C + P + R H TL+ R + + L+I G + Sbjct: 3730 TATLWCELSKAAPVEWRKGH------ETLR-------DGDRHSLRQDGSRCELQIRGLAV 3776 Query: 1060 EDEGVYIC-----EASNTLGQASASADFDAQAVNVQVWPGAT-VREGQLVNLTCLVWTTH 1113 D G Y C S TL + A F N + GAT V + +L + W Sbjct: 3777 VDAGEYSCVCGQERTSATLTVRALPARFIEDVKNQEAREGATAVLQCELSKAAPVEWRKG 3836 Query: 1114 PAQL----TYTWYQDGQQ-RLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV 1168 L Y+ QDG + L H + +V D Y C G + L+ V Sbjct: 3837 SETLRGGDRYSLRQDGTRCELQIHGL-----SVADTGEYSCVCGQERTSATLTVRAPQPV 3891 Query: 1169 LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPN----TL 1224 P L++ G A + C + S P A + S G L + P T Sbjct: 3892 FREP-----LQSLQAEEGSTATLQCEL-SEPTATVVWSKGG-LQLQANGRREPRLQGCTA 3944 Query: 1225 RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPE---AAVPEGAPITVTC 1281 L L+ Q D G Y+C+ G TS L + V E V EG + C Sbjct: 3945 ELVLQDLQREDTGEYTCTC----GSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLCC 4000 Query: 1282 ADPAAHAPTLYTWYHNG---------RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGT 1332 + A W + +Q+G AA L + AG Y+C Q Sbjct: 4001 --ELSRAGASVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSM 4058 Query: 1333 RS 1334 S Sbjct: 4059 AS 4060 Score = 103 bits (257), Expect = 1e-21 Identities = 274/1256 (21%), Positives = 423/1256 (33%), Gaps = 235/1256 (18%) Query: 274 IKWLKDGVRL--------QTKTGVLHLPQAAW---SDAGVYTCQA-ENGVGSLVSPPISL 321 + W KDG+ L Q G H AA D G Y+C+ E+ V + Sbjct: 828 VHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPK 887 Query: 322 HIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH---------S 372 +F E + TL C A + +WYK+ L + + Sbjct: 888 VVFAKEQLARRKLQAEAGASATLSCEV---AQAQTEVTWYKDGKKLSSSSKVCMEATGCT 944 Query: 373 HTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLT----PVLTAFLETQAGLV 428 L + A +AD G Y CE G +R + V P + V + ++ +AG Sbjct: 945 RRLVVQQAGQADAGEYSCEA----GGQRLS-FHLDVKEPKVVFAKDQVAHSEVQAEAGAS 999 Query: 429 GILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGE 488 L C V + G + +S + + RL ++ +TD+G+ Sbjct: 1000 ATLSCEVAQAQTEVMWYKDGKKLSSSLKVHVE--------AKGCRRRLVVQQAGKTDAGD 1051 Query: 489 YKCSATNSLGNATSTLDFHANAARLLISPAAEVVE------GQAVTLSCRSGLSPTPDAR 542 Y C A + H +++ + V G + LSC + T Sbjct: 1052 YSCEARGQ----RVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQT---E 1104 Query: 543 FSWYLNGALLH---------EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLT 593 +WY +G L +G L+LP A DAG Y C A G + Sbjct: 1105 VTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEA-------GGQRVSFHL 1157 Query: 594 VLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGC 653 + P+ + + A AG +L C V P +KD +S S Sbjct: 1158 HITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQ--PQTEVTWYKDGKKLSS--SSKVR 1213 Query: 654 STCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAI 713 GC+ R+ V + + G Y CEA S V A Sbjct: 1214 MEVKGCTRRLVVQQVGKA-----------DAGEYSCEAGGQ--RVSFQLHITEPKAVFAK 1260 Query: 714 APSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLETVTLLPV 764 + TEA + +S E A + +W+++G + A G + + + Sbjct: 1261 EQLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQA 1320 Query: 765 ARTDAALYACRILTEAGAQ-------LSTPVLLSVLYPPDRPKLSALLDMGQGHMALFIC 817 + DA Y C EAG Q +S P + K+ A G +A C Sbjct: 1321 GQADAGEYTC----EAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQA----EAGAIATLSC 1372 Query: 818 TVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCE 877 V + G+ L ++S + + +A + +L V++ D+G Y CE Sbjct: 1373 EVAQAQTEVTWYKDGKKLSSSS---------KVRMEAVGCTRRLVVQQACQADTGEYSCE 1423 Query: 878 ATNVLGSSNTSLFFQVRGAWV------QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWY 931 A G S V V V + Q G + LSC+V T WY Sbjct: 1424 A----GGQRLSFSLDVAEPKVVFAKEQPVHREVQAQAGASTTLSCEV---AQAQTEVMWY 1476 Query: 932 RDGQPLQESTSATLRFAAITLTQ-----------AGAYHCQAQAPGSATTSLAAPISLHV 980 +DG+ L S S+ +R A+ T+ AG Y C+A GS S ++ Sbjct: 1477 KDGKKL--SFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCEA---GSQRLSFHLHVAEPK 1531 Query: 981 SYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPR 1040 + + + + G L C V G +L SS + Sbjct: 1532 AVFAKEQPASREVQAEAGTSATLSCEVAQAQTEVTWYKDGKKL------------SSSSK 1579 Query: 1041 LHVAVAPNTLRLEIHGAMLEDEGVYICEASNT-----LGQASASADFDAQAV---NVQVW 1092 + + T RL + A D G Y C+A + L A F + VQ Sbjct: 1580 VRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAE 1639 Query: 1093 PGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVR---------- 1142 GA+ L+C V AQ TWY+DG++ + + + V Sbjct: 1640 AGASA------TLSCEV---AQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQ 1690 Query: 1143 -DATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALV--LCTVDSRP 1199 DA Y C G + RL L+ + R R L+ + L L T + Sbjct: 1691 ADAGEYSCEAGGQRLSFRL-HVAELEPQISERPCRREPLVVKEHEDIILTATLATPSAAT 1749 Query: 1200 PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE 1259 L R AS +T L + G Q D YSC +G +++E Sbjct: 1750 VTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCR----VGAEGQDFPVQVE 1805 Query: 1260 GVRV----ILAPEAAVPEGAPITVTCADPAAHAPTLY----TWYHNGRWLQ---EGPAAS 1308 V +L P G +T+ C A A ++ T G+ Q EGP S Sbjct: 1806 EVAAKFCRLLEPVCG-ELGGTVTLACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRS 1864 Query: 1309 LSFLVATRAHAGAYSCQAQD----AQGTRS------------------SRPAALQVLYAP 1346 L+ L AG Y C+++D AQ T S A Q + +P Sbjct: 1865 LTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVVSP 1924 Query: 1347 QDAVLSSFRDSR----ARSMAVIQCTVD-SEPPAELALSHDGKVLATSSGVHSLAS 1397 D + FRD + A+ Q S ++L L G++ + G S A+ Sbjct: 1925 SDVAVVWFRDGALLQPSEKFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAA 1980 Score = 102 bits (255), Expect = 2e-21 Identities = 283/1294 (21%), Positives = 450/1294 (34%), Gaps = 235/1294 (18%) Query: 59 WYYDYSGQRQVVSHSADPKLVEARFRG--------RTEFMGNPEHRVCNLLLKDLQPEDS 110 W G+R V + D LVE + G E++ PE L + D+ E Sbjct: 533 WSPPPHGERPV---TIDGYLVEKKKLGTYTWIRCHEAEWVATPE-----LTVADVAEEG- 583 Query: 111 GSYNFRFEISEVNRWS-----DVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYV 165 NF+F +S +N + + GT V + + V T V+ +EG EV F+ Sbjct: 584 ---NFQFRVSALNSFGQSPYLEFPGT-VHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVA 639 Query: 166 CLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLE---TLHMAMSWQDHGRILRCQLSVA 222 E W + Q + + V + T H + + QL Sbjct: 640 SAGE-----W---------FLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFV 685 Query: 223 NHRAQSEIHLQVKYAPKGVKILLSPSG--RNILPG--ELVTLTCQVNSSYPAVSSIKWLK 278 + +S I ++V+ AP G+ P+ R +L E L +++ AV+ WLK Sbjct: 686 ANGIESSIRMEVRAAP-GLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVT---WLK 741 Query: 279 DGVRL--------QTKTG--VLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEV 328 DG L Q G VL + A DAG+Y C + G + L F+ + Sbjct: 742 DGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKD 801 Query: 329 QVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHV---------LLEDAHS-HTLRLH 378 + C T + + + WYK+ + L ED + H L Sbjct: 802 MAGSCVDAVAGGPAQFECET---SEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAA 858 Query: 379 LATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLT----PVLTAFLETQAGLVGILHCS 434 TR D G Y C V E S + V+ P + + L+ +AG L C Sbjct: 859 TVTRQDEGTYSCRV-----GEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSCE 913 Query: 435 VVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSAT 494 V G + +S+ + + + RL ++ + D+GEY C A Sbjct: 914 VAQAQTEVTWYKDGKKLSSSS--------KVCMEATGCTRRLVVQQAGQADAGEYSCEAG 965 Query: 495 NSLGNATSTLDFHANAARLLISPAAEVVE--------GQAVTLSCRSGLSPTPDARFSWY 546 L FH + + A + V G + TLSC + T WY Sbjct: 966 GQ------RLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSCEVAQAQT---EVMWY 1016 Query: 547 LNGALLH---------EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYP 597 +G L +G L++ A TDAG Y C AR G S +++ Sbjct: 1017 KDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEAR-GQRVSFRLHITEPKMMFA 1075 Query: 598 PRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLL-HKDRVVATSLPSGGGCSTC 656 Q + A AG +L C V A+ ++ +KD +S G Sbjct: 1076 KEQSVH------NEVQAEAGASAMLSCEV---AQAQTEVTWYKDGKKLSSSSKVG--MEV 1124 Query: 657 GGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPS 716 GC+ R+ + +A + G Y CEA S V A S Sbjct: 1125 KGCTRRLVLPQAGK-----------ADAGEYSCEAGGQ--RVSFHLHITEPKGVFAKEQS 1171 Query: 717 HTLQEGTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLETVTLLPVART 767 + EA T +S E A +W+++G + +G + + V + Sbjct: 1172 VHNEVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKA 1231 Query: 768 DAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLD----MGQGHMALFICTVDSRP 823 DA Y+C EAG Q L + P L+ G A C V Sbjct: 1232 DAGEYSC----EAGGQ-RVSFQLHITEPKAVFAKEQLVHNEVRTEAGASATLSCEVAQAQ 1286 Query: 824 LALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLG 883 + G+ L ++S + + +A +L V++ G D+G Y CEA G Sbjct: 1287 TEVTWYKDGKKLSSSS---------KVRIEAAGCMRQLVVQQAGQADAGEYTCEA----G 1333 Query: 884 SSNTSLFFQVRGAWVQVSPSP------ELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL 937 S V + + + G LSC+V E T WY+DG+ L Sbjct: 1334 GQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQTEVT---WYKDGKKL 1390 Query: 938 QESTSATLRFAAITLTQ-----------AGAYHCQAQAPG-SATTSLAAPISLHVSYAPR 985 S+S+ +R A+ T+ G Y C+A S + +A P + P Sbjct: 1391 --SSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVFAKEQPV 1448 Query: 986 HVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAV 1045 H + G L C V + G +L S ++ + Sbjct: 1449 H----REVQAQAGASTTLSCEVAQAQTEVMWYKDGKKL------------SFSSKVRMEA 1492 Query: 1046 APNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNL 1105 T RL + A G Y CEA + + +AV + P + + + Sbjct: 1493 VGCTRRLVVQQAGQAVAGEYSCEAGSQRLSFHLHV-AEPKAVFAKEQPASREVQAEAGTS 1551 Query: 1106 TCLVWTTHPAQLTYTWYQDGQQ-------RLDA----HSIPLPNVTVRDATSYRCGVGPP 1154 L AQ TWY+DG++ R++A + + DA Y C G Sbjct: 1552 ATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQ 1611 Query: 1155 GRAPRL--SRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLL 1212 + L + P + P + +++ G A + C V ++ ++ G+ L Sbjct: 1612 RLSFHLHVAEPKVVFAKEQPAHRE----VQAEAGASATLSCEV-AQAQTEVTWYKDGKKL 1666 Query: 1213 ASST---AASVPNTLRLELRGPQPRDEGFYSCSA 1243 +SS+ +V T RL ++ D G YSC A Sbjct: 1667 SSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA 1700 Score = 94.7 bits (234), Expect = 7e-19 Identities = 329/1543 (21%), Positives = 511/1543 (33%), Gaps = 276/1543 (17%) Query: 229 EIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSS-YPAVSSIKWLKDGVRLQTKT 287 ++ + A + LL P+ + G T C+V S PAVS W KDG RL Sbjct: 98 QVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVS---WSKDGRRLGEPD 154 Query: 288 G------------VLHLPQAAWSDAGVYTCQAENGVGSLVS----------------PPI 319 G L + A D G Y +AEN +G+ + P Sbjct: 155 GPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGT 214 Query: 320 SLHIFMAEVQV---------SPAGP---------ILENQTVTLVCNTPNEAPSDLRYSWY 361 S +A +Q +PA P + E + L C E + W Sbjct: 215 STAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPET--VWK 272 Query: 362 KN---------HVLLEDAHSH-TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHP 411 K+ HV+ EDA + L++ ++D G Y C N+ G S + VV Sbjct: 273 KDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVV--RE 330 Query: 412 PLTPVLTAF--LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTS 469 P P LE + C V + AS + GT Sbjct: 331 PAVPFKKRLQDLEVREKESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEE----GTE 386 Query: 470 GPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTL 529 RL +R++ D Y C + L N R L P V + Sbjct: 387 R----RLTVRNVSADDDAVYICETPEG-SRTVAELAVQGNLLRKL--PRKTAVRVGDTAM 439 Query: 530 SCRSGLSPTPDARFSWYLNG---------ALLHEGPGSSLLLPAASSTDAGSY-----HC 575 C P W N A+ EG +L + D G C Sbjct: 440 FCVELAVPVGPVH--WLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDC 497 Query: 576 RARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635 + S P P L PP P R++ + S PP + Sbjct: 498 QTSTQFCVSAPRKPP----LQPPVDPVVKARMESSVILSW------------SPPPHGER 541 Query: 636 LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695 + D + G T C V P L ++ EEG + S AL Sbjct: 542 PVTIDGYLVEKKKLG--TYTWIRCHEAEWVA-TPELTVADV-----AEEGNFQFRVS-AL 592 Query: 696 GNASTSATFNGQATV-----LAI-APSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRN 747 + S TV LA+ P +Q EG E + +++ +AG WF + Sbjct: 593 NSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVASAGE-----WFLD 647 Query: 748 G-VLWAQGPLE-----TVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPP----D 797 G L A E T L + A+L+ ++ A + + + + V P + Sbjct: 648 GQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANG-IESSIRMEVRAAPGLTAN 706 Query: 798 RPKLSALLD-MGQGHM-ALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAE 855 +P +A + + + H A + + + A+ L G L S GP +++ +A Sbjct: 707 KPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTL---SPGP------KYEVQAS 757 Query: 856 ANSLKLEVRELGLGDSGSYRCEA--------TNVLGSSNTSLFFQVRGAWVQ-VSPSPEL 906 A L VR++ D+G Y C + +V G + L + G+ V V+ P Sbjct: 758 AGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLAR-FLHKDMAGSCVDAVAGGPAQ 816 Query: 907 QEGQAVVLSCQVHTGVPEGTSYRWYRDGQP--------LQESTSATLRFAAITLTQ--AG 956 E + VH WY+DG LQE R A T+T+ G Sbjct: 817 FECETSEAHVHVH----------WYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEG 866 Query: 957 AYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLR 1016 Y C+ G + +S + + G L C V Sbjct: 867 TYSCRV---GEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVTW 923 Query: 1017 LLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQA 1076 G +L SS ++ + T RL + A D G Y CEA G Sbjct: 924 YKDGKKL------------SSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEA----GGQ 967 Query: 1077 SASADFDAQAVNV-----QVWPGATVRE-GQLVNLTCLVWTTHPAQLTYTWYQDGQQ--- 1127 S D + V QV E G L+C V AQ WY+DG++ Sbjct: 968 RLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSCEV---AQAQTEVMWYKDGKKLSS 1024 Query: 1128 RLDAH--------SIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY 1179 L H + + DA Y C G+ IT + + + Sbjct: 1025 SLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEA--RGQRVSFRLHITEPKMMFAKEQSVHN 1082 Query: 1180 LLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVP---NTLRLELRGPQPRDE 1236 +++ G A++ C V ++ ++ G+ L+SS+ + T RL L D Sbjct: 1083 EVQAEAGASAMLSCEV-AQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADA 1141 Query: 1237 GFYSCSARSPLGQANTSLELRLEGVRVILAPEAA----VPEGAPITVTCADPAAHAPTLY 1292 G YSC A G S L + + + A E + V A T + A T Sbjct: 1142 GEYSCEA----GGQRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEV 1197 Query: 1293 TWYHNGRWLQEGPAASLSFLVATR---------AHAGAYSCQAQDAQGTRSSRPAALQVL 1343 TWY +G+ L + TR A AG YSC+A + + + + Sbjct: 1198 TWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEPKAV 1257 Query: 1344 YAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403 +A + V + R + A + A + C V ++ E+ DGK L++SS V A+G Sbjct: 1258 FAKEQLVHNEVR-TEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRIEAAG----- 1310 Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNL 1463 R + Q AG+ T Q L + V +A + GA L Sbjct: 1311 CMRQLVVQQAGQADAGEYTCEAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATL 1370 Query: 1464 SCRLLGGPGPVGNSTFAWFWNDRRLHAEP---------VPTLAFTHVARAQAGMYHCLAE 1514 SC + V W+ + ++L + L +A G Y C A Sbjct: 1371 SCEVAQAQTEV-----TWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAG 1425 Query: 1515 LPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVA 1574 + + +V++ + P V+ + G L C V + G +L Sbjct: 1426 GQRLSFSLDVAEPKVVFAKEQPVHRE-VQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSF 1484 Query: 1575 SSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASN 1617 SS+ + + A R+ ++ + GEY C A + Sbjct: 1485 SSK---------VRMEAVGCTRRLVVQQAGQAVAGEYSCEAGS 1518 Score = 94.7 bits (234), Expect = 7e-19 Identities = 362/1685 (21%), Positives = 573/1685 (34%), Gaps = 282/1685 (16%) Query: 78 LVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTE 137 L+E R G+ + + E L + L+ DS +Y ++ V+G V + E Sbjct: 2952 LLELRASGKHQ--PSQEGLTLRLTISALEKADSDTYTCDIGQAQSRAQLLVQGRRVHIIE 3009 Query: 138 EPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQW-QGQDPARSVTFNSQKFEPTGV 196 + V++ EG+ F C + + W + P + N +P G Sbjct: 3010 D------LEDVDVQEGSSATFRCR---ISPANYEPVHWFLDKTPLHANELNEIDAQPGGY 3060 Query: 197 GHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGE 256 H+ TL ++ +D G I + RA + + + K + ++ + I GE Sbjct: 3061 -HVLTLRQ-LALKDSGTIY---FEAGDQRASAALRVTEKPSVFSREL----TDATITEGE 3111 Query: 257 LVTLTCQVNSSYPAVSSIKWLKDGVRLQTKT----------GVLHLPQAAWSDAGVYTCQ 306 +TL C+ ++ V W KDG L+ L + A D+G Y C+ Sbjct: 3112 DLTLVCETSTCDIPVC---WTKDGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKCE 3168 Query: 307 AENGVGSLV----SPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYK 362 A S + + P+ + +++V LE TL C + A W Sbjct: 3169 AGGACSSSIVRVHARPVRFQEALKDLEV------LEGGAATLRCVLSSVAAP---VKWCY 3219 Query: 363 NHVLLEDAHSHTLR-----LHLATR----ADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413 + +L ++LR L L R D+G Y C G + + V P Sbjct: 3220 GNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSF----GDQTTSATLTVTALPAQ 3275 Query: 414 TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNS 473 E G L C + A + G L GD R+ Sbjct: 3276 FIGKLRNKEATEGATATLRCEL--SKAAPVEWRKGSETLRD--GD-----RYCLRQDGAM 3326 Query: 474 LRLEIRDLEETDSGEYKCSATNSLGNATSTL-DFHANAARLLISPAAEVVEGQAVTLSCR 532 L+IR L D+ EY C +A+ T+ A+ L E +EG TL C Sbjct: 3327 CELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFIGRL--RHQESIEGATATLRCE 3384 Query: 533 SGLSPTPDARFSWYLNGALLHEGPGSSLLLPAA---------SSTDAGSYHCRARDGHSA 583 + A W L +G SL A + DAG Y C + ++ Sbjct: 3385 LSKA----APVEWRKGRESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSCVCGEERTS 3440 Query: 584 SGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVV 643 A LTV P + FT L + A GA +L C + P R Sbjct: 3441 ------ATLTVKALPAK--FTEGLRNEEAVEGA--TAMLWCELSKVAPVEW------RKG 3484 Query: 644 ATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSAT 703 +L G R + + ++I + + G YLC G TSAT Sbjct: 3485 PENLRDG----------DRYILRQEGTRCELQICGLAMADAGEYLC----VCGQERTSAT 3530 Query: 704 FNGQ---ATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSW------FRNG---VLW 751 + A + + +EG A L C ++ S A W R+G L Sbjct: 3531 LTIRALPARFIEDVKNQEAREGATAVLQCELN-----SAAPVEWRKGSETLRDGDRYSLR 3585 Query: 752 AQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGH 811 G + + +A D Y+C E + + T L + + A +G Sbjct: 3586 QDGTKCELQIRGLAMADTGEYSCVCGQERTSAMLTVRALPIKFTEGLRNEEAT----EGA 3641 Query: 812 MALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDS 871 A+ C + +A + + G L R + + +L++R L D+ Sbjct: 3642 TAVLRCELSK--MAPVEWWKGHETLRDG--------DRHSLRQDGARCELQIRGLVAEDA 3691 Query: 872 GSYRCEATNVLGSSNTSLFFQVR---GAWVQVSPSPELQEGQAVVLSCQVHTGVPE--GT 926 G Y C + G TS VR +++ + E EG L C++ P Sbjct: 3692 GEYLC----MCGKERTSAMLTVRAMPSKFIEGLRNEEATEGDTATLWCELSKAAPVEWRK 3747 Query: 927 SYRWYRDGQP---LQESTSATLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSY 982 + RDG Q+ + L+ + + AG Y C Q SAT ++ A Sbjct: 3748 GHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTSATLTVRA-------L 3800 Query: 983 APRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLH 1042 R + + G +L C + P + R + TL+G R Sbjct: 3801 PARFIEDVKNQEAREGATAVLQCELSKAAPVEW------RKGSETLRG-------GDRYS 3847 Query: 1043 VAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQA---VNVQVWPGATVRE 1099 + L+IHG + D G Y C GQ SA +A V + E Sbjct: 3848 LRQDGTRCELQIHGLSVADTGEYSC----VCGQERTSATLTVRAPQPVFREPLQSLQAEE 3903 Query: 1100 GQLVNLTC--------LVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGV 1151 G L C +VW+ QL ++ + + + L ++ D Y C Sbjct: 3904 GSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTC 3963 Query: 1152 GPPGRAPRLSRPITLDVLYAP-RNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAG- 1209 G + TL V AP R LR E G A + C + SR A + Sbjct: 3964 GSQATS------ATLTVTAAPVRFLRELQHQEVDEGGTAHLCCEL-SRAGASVEWRKGSL 4016 Query: 1210 RLLASSTAASVPNTLRLEL--RGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP 1267 +L + V + EL RG + D G Y+C Q+ SL +R+ + Sbjct: 4017 QLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHT--QSMASLSVRVPRPKFKTRL 4074 Query: 1268 EAAVPEGAPITVTCADPA-AHAPTLYTWYHNGRWLQEGPAASLSFLVATR---------A 1317 ++ E I C + A + + W G L GP + ATR Sbjct: 4075 QSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEAK 4134 Query: 1318 HAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQ--CTVDSEPPA 1375 G Y+C T + AA + P+ ++ D+ + ++ C V Sbjct: 4135 DTGEYACV------TGGQKTAASLRVTEPEVTIVRGLVDAEVTADEDVEFSCEVSRAGAT 4188 Query: 1376 ELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQ-VQDVPAGDDTYVCTAQNLLGSI 1434 + G L S+ V +A G + + LRL+ V AG T LG+ Sbjct: 4189 GVQWCLQGLPL-QSNEVTEVAVRDGRI----HTLRLKGVTPEDAG------TVSFHLGNH 4237 Query: 1435 STIGRLQVEGARV-VAEPGLDV--PEGAALNLSCRLLGGPGPV------GNSTFAWFWND 1485 ++ +L V V + EP DV EG + CRL G G A ND Sbjct: 4238 ASSAQLTVRAPEVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMND 4297 Query: 1486 RRLHAEPVPTLAFTHVARAQAG--MYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVE 1543 + + L V AG +H S+ L+V + VE Sbjct: 4298 ITVEQGTLHLLTLHKVTLEDAGTVSFHV-------GTCSSEAQLKVTAKNTVVRGLENVE 4350 Query: 1544 PEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALR--VDIE 1601 G + +C++ +A+ T L V +S+ + V+ N LR + ++ Sbjct: 4351 ALEGGEALFECQLSQPEVAAHTWLLDDEPVHTSE--------NAEVVFFENGLRHLLLLK 4402 Query: 1602 ALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGL--LLLLLGL 1659 LRP D C + + G TS + VR W L +L L + G Sbjct: 4403 NLRPQDS----CRVTFLAGDMVTSAFLTVRG-----------WRLEILEPLKNAAVRAGA 4447 Query: 1660 GACYT 1664 AC+T Sbjct: 4448 QACFT 4452 Score = 85.9 bits (211), Expect = 3e-16 Identities = 282/1247 (22%), Positives = 418/1247 (33%), Gaps = 244/1247 (19%) Query: 508 ANAARLLISPAAEVVE-GQAVTLSCRSGLSPTPDARFSWYLN------GA---LLHEGPG 557 + A R L P A VV G+ TLSC+ +PTP SW + GA L +G Sbjct: 7 SGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQV--SWEKDQQPVAAGARFRLAQDGDL 64 Query: 558 SSLLLPAASSTDAGSYHCRARD--GHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAG 615 L + + D+G Y CRAR+ G + + + P F R + Sbjct: 65 YRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPT--SIRVR 122 Query: 616 AGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVE 675 G CRV P + R + P G PR++V + + Sbjct: 123 EGSEATFRCRVGGSPRPAVSWSKDGRRLGE--PDG----------PRVRVEELGEASALR 170 Query: 676 IHNPLLEEEGLYLCEASNALGNASTSA----------TFNGQATVLAIAPSH-------- 717 I + G Y A N LG AS +A T + T A +H Sbjct: 171 IRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAM 230 Query: 718 -----------------TLQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETV- 759 T+ EG A L+C V+ E W ++G L +G V Sbjct: 231 RAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETV---WKKDGQLVTEGRRHVVY 287 Query: 760 ---------TLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP--PDRPKLSALLDMG 808 +L ++D LY C G Q + VL+ V P P + +L L++ Sbjct: 288 EDAQENFVLKILFCKQSDRGLYTCTASNLVG-QTYSSVLVVVREPAVPFKKRLQD-LEVR 345 Query: 809 QGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGL 868 + A F+C V +P A F E L S ++ + E +L VR + Sbjct: 346 EKESATFLCEV-PQPSTEAAWFKEETRLWAS--------AKYGIEEEGTERRLTVRNVSA 396 Query: 869 GDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSY 928 D Y CE S T V+G ++ P + C V VP G + Sbjct: 397 DDDAVYICETPE---GSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFC-VELAVPVGPVH 452 Query: 929 RWYRDGQPL---------QESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLH 979 W R+ + + E T TL + L G A G TS +S Sbjct: 453 -WLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMA---GDCQTSTQFCVS-- 506 Query: 980 VSYAPRHVTLTTLMD-TGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSS 1038 APR L +D R+ + S PP HG+R V T+ G + Sbjct: 507 ---APRKPPLQPPVDPVVKARMESSVILSWSPPP------HGERPV--TIDGYLVEKKKL 555 Query: 1039 P-----RLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWP 1093 R H A T L + E + A N+ GQ S +F V + P Sbjct: 556 GTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQ-SPYLEFPG---TVHLAP 611 Query: 1094 GATVR---------EGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSI-------PLP 1137 VR EG V + + + W+ DG Q L A S+ Sbjct: 612 KLAVRTPLKAVQAVEGGEVTFSVDLTVASAGE----WFLDG-QALKASSVYEIHCDRTRH 666 Query: 1138 NVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAP-----------------RNLRLTYL 1180 +T+R+ + G A + I ++V AP R L Sbjct: 667 TLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQL 726 Query: 1181 LESHGGQLALVLCTVDSRP----PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDE 1236 L Q A V D R P + AGR + L +R D Sbjct: 727 LAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRV-------------LLVRDVARDDA 773 Query: 1237 GFYSCSARSPLGQANTSLELRLEGVRVILAPEAA-----VPEGAPITVTCADPAAHAPTL 1291 G Y C +R + +L ++G+ L + A G P C AH Sbjct: 774 GLYECVSRG----GRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPAQFECETSEAHVHV- 828 Query: 1292 YTWYHNG--------RWLQE--GPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQ 1341 WY +G R+LQE G L TR G YSC+ + R + + Sbjct: 829 -HWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPK 887 Query: 1342 VLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGH 1401 V++A + + + A + A + C V ++ E+ DGK L++SS V A+G Sbjct: 888 VVFAKEQLARRKLQ-AEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVCMEATG--- 942 Query: 1402 VQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAAL 1461 R + Q AG+ + Q L + V VA + GA+ Sbjct: 943 --CTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASA 1000 Query: 1462 NLSCRLLGGPGPVGNSTFAWFWNDRRL------HAEPV---PTLAFTHVARAQAGMYHCL 1512 LSC + V W+ + ++L H E L + AG Y C Sbjct: 1001 TLSCEVAQAQTEV-----MWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCE 1055 Query: 1513 AELPTGAAASAPVMLRVLYP----PKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHL 1568 A L + P K ++ V+ E G +L C V ++ +T + Sbjct: 1056 AR-----GQRVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEV-AQAQTEVTWYK 1109 Query: 1569 GSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSA 1615 + ++SS G + L P A + +D GEY C A Sbjct: 1110 DGKKLSSSSKVGMEVKGCTRRLVLPQAGK--------ADAGEYSCEA 1148 Score = 81.6 bits (200), Expect = 6e-15 Identities = 277/1174 (23%), Positives = 409/1174 (34%), Gaps = 187/1174 (15%) Query: 255 GELVTLTCQVNSSYPAVSSIKW------LKDG----VRLQTKTGVLHLPQAAWSDAGVYT 304 G L C+++ V+ ++W L+DG +R + L + A +DAG Y Sbjct: 3464 GATAMLWCELSK----VAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYL 3519 Query: 305 CQA--ENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYK 362 C E +L + F+ +V+ A E T L C + AP + W K Sbjct: 3520 CVCGQERTSATLTIRALPAR-FIEDVKNQEAR---EGATAVLQCELNSAAPVE----WRK 3571 Query: 363 NHVLLEDAHSHTLR---------LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413 L D ++LR + ADTG Y C V G ER+ + V P Sbjct: 3572 GSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAMLTVRALPIK 3627 Query: 414 TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSD-HSPRFSGTSGPN 472 E G +L C + H T D D HS R G Sbjct: 3628 FTEGLRNEEATEGATAVLRCELSKMAPVEWWKGH------ETLRDGDRHSLRQDGAR--- 3678 Query: 473 SLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA-AEVVEGQAVTLSC 531 L+IR L D+GEY C +A T+ A ++ + E EG TL C Sbjct: 3679 -CELQIRGLVAEDAGEYLCMCGKERTSAMLTV--RAMPSKFIEGLRNEEATEGDTATLWC 3735 Query: 532 R-SGLSPTPDARFSWYLNG----ALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGP 586 S +P + L +L +G L + + DAG Y C ++ Sbjct: 3736 ELSKAAPVEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTS--- 3792 Query: 587 SSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATS 646 A LTV P + F D+ A G +L C + P + Sbjct: 3793 ---ATLTVRALPAR--FIE--DVKNQEAREGATAVLQCELSKAAPVEWRK---------- 3835 Query: 647 LPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNG 706 G T G R + + ++IH + + G Y C G TSAT Sbjct: 3836 -----GSETLRG-GDRYSLRQDGTRCELQIHGLSVADTGEYSC----VCGQERTSATLTV 3885 Query: 707 QATVLAIA-PSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRNGV-LWAQGPLET---- 758 +A P +LQ EG+ A L C +S A W + G+ L A G E Sbjct: 3886 RAPQPVFREPLQSLQAEEGSTATLQCELSEPTA----TVVWSKGGLQLQANGRREPRLQG 3941 Query: 759 ----VTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMAL 814 + L + R D Y C G+Q ++ L P + ++ +G A Sbjct: 3942 CTAELVLQDLQREDTGEYTCT----CGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAH 3997 Query: 815 FICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSY 874 C + SR A + G L ++Q + + +L VR + D+G Y Sbjct: 3998 LCCEL-SRAGASVEWRKGSLQLFPC--------AKYQMVQDGAAAELLVRGVEQEDAGDY 4048 Query: 875 RCEATNVLGSSNTSLFFQV-RGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRD 933 C+ + S SL +V R + S E + G L CQ+ + G +W ++ Sbjct: 4049 TCDTGHT--QSMASLSVRVPRPKFKTRLQSLEQETGDIARLCCQL-SDAESGAVVQWLKE 4105 Query: 934 GQPLQESTSATLRFAAITLTQAGAYHCQAQAPGS---ATTSLAAPISLHVSYAPRHVTLT 990 G L +R T + + +A+ G T SL V+ VT+ Sbjct: 4106 GVELHAGPKYEMRSQGAT-RELLIHQLEAKDTGEYACVTGGQKTAASLRVTEP--EVTIV 4162 Query: 991 TLMDTGPGRLGLLLCRVDSDPPAQLRL---LHGDRLVASTLQGVGGPEGSSPRLHVAVAP 1047 GL+ V +D + G V LQG+ P S+ VAV Sbjct: 4163 R---------GLVDAEVTADEDVEFSCEVSRAGATGVQWCLQGL--PLQSNEVTEVAVRD 4211 Query: 1048 NTLR-LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWP---GATVREGQLV 1103 + L + G ED G S LG ++SA +A V + + EGQ Sbjct: 4212 GRIHTLRLKGVTPEDAGT----VSFHLGNHASSAQLTVRAPEVTILEPLQDVQLSEGQDA 4267 Query: 1104 NLTCLV---------WTTHPAQLTYTWYQD-GQQRLDAHSIPLPNVTVRDATSYRCGVGP 1153 + C + W L D ++ H + L VT+ DA + VG Sbjct: 4268 SFQCRLSRASGQEARWALGGVPLQANEMNDITVEQGTLHLLTLHKVTLEDAGTVSFHVGT 4327 Query: 1154 PGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLA 1213 +L V+ N+ E+ G AL C + A + Sbjct: 4328 CSSEAQLKVTAKNTVVRGLENV------EALEGGEALFECQLSQPEVAAHTWLLDDEPVH 4381 Query: 1214 SSTAASV---PNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRV-ILAP 1267 +S A V N LR L L+ +P+D SC G TS L + G R+ IL P Sbjct: 4382 TSENAEVVFFENGLRHLLLLKNLRPQD----SCRVTFLAGDMVTSAFLTVRGWRLEILEP 4437 Query: 1268 --EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQ----------EGPAASLSFLVAT 1315 AAV GA TC A +WY NG +Q +G +L A Sbjct: 4438 LKNAAVRAGAQACFTCTLSEAVPVGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSAQ 4497 Query: 1316 RAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDA 1349 HAG + +DA S+R L + P+DA Sbjct: 4498 PHHAGEVTFACRDA--VASARLTVLGLPDPPEDA 4529 Score = 77.4 bits (189), Expect = 1e-13 Identities = 299/1338 (22%), Positives = 457/1338 (34%), Gaps = 238/1338 (17%) Query: 225 RAQSEIHLQVKYAPKGVKILLSP-SGRNILPGELVTLTCQVNSSYPAVSSIKWLKDG--- 280 +++S L V P + L P +GR + + V L+C PA +++W KD Sbjct: 2455 KSRSSARLVVSDIPVVLTRPLEPKTGREL---QSVVLSCDFR---PAPKAVQWYKDDTPL 2508 Query: 281 -------VRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPA 333 + L+ + L + + +DAGVY CQA GS S S + + +V+ Sbjct: 2509 SPSEKFKMSLEGQMAELRILRLMPADAGVYRCQA----GSAHS---STEVTVEAREVTVT 2561 Query: 334 GPI-----LENQTVTLVCNTPNEAPSDLRYSWYKN---------HVLLEDAHSHTLRLHL 379 GP+ E + C +E D W N H + HTL L Sbjct: 2562 GPLQDAEATEEGWASFSCELSHE---DEEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKS 2618 Query: 380 ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEP 439 RAD G V S R + V V L + G + L C VS+P Sbjct: 2619 IQRADAGIVRASSLKVSTSAR---LEVRVKPVVFLKALDDLSAEERGTLA-LQCE-VSDP 2673 Query: 440 LATLVLSHGGHILA-STSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG 498 A +V G L S D H+ +GT G L + D+ D+G Y C + Sbjct: 2674 EAHVVWRKDGVQLGPSDKYDFLHT---AGTRG-----LVVHDVSPEDAGLYTCHVGSEET 2725 Query: 499 NATSTL-DFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALL----- 552 A + D H + L EV+EG++ + C D W + G + Sbjct: 2726 RARVRVHDLHVGITKRL--KTMEVLEGESCSFECVLSHESASDPAM-WTVGGKTVGSSSR 2782 Query: 553 ----HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLD 608 +G L++ A+ +DAG S G +S A L V R+ Sbjct: 2783 FQATRQGRKYILVVREAAPSDAGEV------VFSVRGLTSKASLIV----RERPAAIIKP 2832 Query: 609 LDAAGAGAGRRGLLLCRVD-SDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTK 667 L+ G L C + + P KDR S + V Sbjct: 2833 LEDQWVAPGEDVELRCELSRAGTPVHWL---KDRKAIRK-------------SQKYDVVC 2876 Query: 668 APNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANL 727 + + I L++ G Y CE + AS + ++GT A Sbjct: 2877 EGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEELTNLQVEEKGT-AVF 2935 Query: 728 TCNVSREAAGSPANFSWFRNGVL----------WAQGPLETVTLLPVARTDAALYACRIL 777 TC A A +W R G+L +G +T+ + + D+ Y C I Sbjct: 2936 TCKTEHPA----ATVTW-RKGLLELRASGKHQPSQEGLTLRLTISALEKADSDTYTCDI- 2989 Query: 778 TEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLA 837 AQ +L+ L +D+ +G A F C + A + H Sbjct: 2990 --GQAQSRAQLLVQGRRVHIIEDLED-VDVQEGSSATFRCRISP------ANYEPVHWFL 3040 Query: 838 TSLGPQVPSHGRFQAKAEANS---LKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894 + P H + +A L +R+L L DSG+ EA G S +V Sbjct: 3041 ----DKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEA----GDQRASAALRVT 3092 Query: 895 ---GAWVQVSPSPELQEGQAVVLSCQVHT-GVPEGTSYRWYRDGQPLQ---------EST 941 + + + EG+ + L C+ T +P W +DG+ L+ E Sbjct: 3093 EKPSVFSRELTDATITEGEDLTLVCETSTCDIP----VCWTKDGKTLRGSARCQLSHEGH 3148 Query: 942 SATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLG 1001 A L TL +G Y C +A G+ ++S+ + V + L L G Sbjct: 3149 RAQLLITGATLQDSGRYKC--EAGGACSSSIVRVHARPVRFQEALKDLEVL----EGGAA 3202 Query: 1002 LLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061 L C V S A ++ +G+ ++ + EG+ L L + +D Sbjct: 3203 TLRC-VLSSVAAPVKWCYGNNVLRPGDKYSLRQEGA-----------MLELVVRNLRPQD 3250 Query: 1062 EGVYICE-----ASNTLGQASASADFDAQAVNVQVWPGATVR-EGQLVNLTCLVWTTHPA 1115 G Y C S TL + A F + N + GAT +L + W Sbjct: 3251 SGRYSCSFGDQTTSATLTVTALPAQFIGKLRNKEATEGATATLRCELSKAAPVEWRKGSE 3310 Query: 1116 QL----TYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYA 1171 L Y QDG + + + + DA Y C G R S +T+ + A Sbjct: 3311 TLRDGDRYCLRQDGAM----CELQIRGLAMVDAAEYSCVCG----EERTSASLTIRPMPA 3362 Query: 1172 PRNLRLTYLLESHGGQLALVLCTVDSRPPAQL-----ALSHAGRLLASSTAASVPNTLRL 1226 RL + ES G A + C + P + +L R A L Sbjct: 3363 HFIGRLRH-QESIEGATATLRCELSKAAPVEWRKGRESLRDGDRHSLRQDGA----VCEL 3417 Query: 1227 ELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVI----LAPEAAVPEGAPITVTC- 1281 ++ G D G YSC G+ TS L ++ + L E AV EGA + C Sbjct: 3418 QICGLAVADAGEYSCVC----GEERTSATLTVKALPAKFTEGLRNEEAV-EGATAMLWCE 3472 Query: 1282 ---ADPAAHAPTLYTWYHNGRWL--QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSR 1336 P R++ QEG L A AG Y C R Sbjct: 3473 LSKVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYLCVC------GQER 3526 Query: 1337 PAALQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHDGKVLATSSGVHS 1394 +A + A + ++ AR + AV+QC ++S P E G + Sbjct: 3527 TSATLTIRALPARFIEDVKNQEAREGATAVLQCELNSAAPVE-----------WRKGSET 3575 Query: 1395 LASGTGH-VQVARNALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQVEGARVVAEPG 1452 L G + ++ LQ++ + D Y C + G T L V + G Sbjct: 3576 LRDGDRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAMLTVRALPIKFTEG 3631 Query: 1453 L---DVPEGAALNLSCRL 1467 L + EGA L C L Sbjct: 3632 LRNEEATEGATAVLRCEL 3649 Score = 69.3 bits (168), Expect = 3e-11 Identities = 313/1506 (20%), Positives = 499/1506 (33%), Gaps = 280/1506 (18%) Query: 255 GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYT 304 G TL+C+V A + + W KDG +L + V L + QA + AG Y+ Sbjct: 1457 GASTTLSCEVAQ---AQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYS 1513 Query: 305 CQAENGVGSLVSPPISLHIFMAEVQV-----SPAGPILENQTVTLVCNTPNEAPSDLRYS 359 C+A S +S H+ +AE + PA ++ + T + A + + Sbjct: 1514 CEAG-------SQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATLSCEVAQAQTEVT 1566 Query: 360 WYKNHVLLEDAH---------SHTLRLHLATRADTGFYFCEVQN------VHGSERSGPV 404 WYK+ L + + L + A +AD G Y C+ + +H +E P Sbjct: 1567 WYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHVAE---PK 1623 Query: 405 SVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPR 464 V P + A +AG L C V G + +S+ + Sbjct: 1624 VVFAKEQPAHREVQA----EAGASATLSCEVAQAQTEVTWYKDGKKLSSSS--------K 1671 Query: 465 FSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAA----- 519 + + RL ++ + D+GEY C A G + H IS Sbjct: 1672 VRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQRLSFRLHVAELEPQISERPCRREP 1727 Query: 520 -EVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH---------EGPGSSLLLPAASSTD 569 V E + + L+ L+ A +W +G + +G +L + A D Sbjct: 1728 LVVKEHEDIILTAT--LATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLD 1785 Query: 570 AGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSD 629 + Y CR A G P + + RL L+ G L C + Sbjct: 1786 SAIYSCRV----GAEGQDFPVQVEEVAAK-----FCRL-LEPVCGELGGTVTLACELS-- 1833 Query: 630 PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLC 689 PA +++ R T L G R ++ + + + E+ G Y+C Sbjct: 1834 -PACAEVVW--RCGNTQLRVG----------KRFQMVAEGPVRSLTVLGLRAEDAGEYVC 1880 Query: 690 EASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV 749 E+ + +A + + ++ + +EG EA C VS S WFR+G Sbjct: 1881 ESRDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVVSP----SDVAVVWFRDGA 1936 Query: 750 LWAQGPLETVTLLPVARTDAALYACRILTEAGA------QLSTPVLLSVLYPPDRPKLSA 803 L P E + + + + +L +AG S+ L V P K Sbjct: 1937 LLQ--PSEKFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKL 1994 Query: 804 LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863 + ++ + +RP L LA G V H AE +L + Sbjct: 1995 EPQTVEERSSVTLEVELTRPWPELRWTRNATALAP--GKNVEIH------AEGARHRLVL 2046 Query: 864 RELGLGDSGSYRCEATNVLGSSNTSLFFQVRGA-WVQVSPSPELQEGQAVVLSCQVHTGV 922 +G D G + CE + + L ++R V+ + E +E + Q+ Sbjct: 2047 HNVGFADRGFFGCETPD--DKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQLSHAD 2104 Query: 923 PEGTSYRWYRDGQPLQESTSATL--RFAAITLTQAGAYHCQA-----QAPGSATTSLAAP 975 +G+ W RDG Q+ + L R TLT +G + +A G T++ Sbjct: 2105 VDGS---WTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKAEGVHTSARLVV 2161 Query: 976 ISLHVSYA-PRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034 L VS++ P +TT + L C + S P +R L GV Sbjct: 2162 TELPVSFSRPLQDVVTTEKEKVT-----LECEL-SRPNVDVRWLK---------DGVELR 2206 Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASA---------------- 1078 G + + +A L I+ D+GVY+C+A + AS Sbjct: 2207 AGKT--MAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLA 2264 Query: 1079 -----------SADFDAQAVNVQVWPGATVR--------EGQLVNLTCLVWTTHPAQLTY 1119 +A+ AQ + V+ P VR E L C V A Sbjct: 2265 EDAGEIQFVAENAESRAQ-LRVKELPVTLVRPLRDKIAMEKHRGVLECQV---SRASAQV 2320 Query: 1120 TWYQDGQQRLDA-----------HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV 1168 W++ Q+ + + +V D +Y C G + + + Sbjct: 2321 RWFKGSQELQPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDAGDVKTSAQFF--VEEQS 2378 Query: 1169 LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLEL 1228 + R L+ ++E RPP + L T + LE Sbjct: 2379 ITIVRGLQDVTVMEPAPAWFECETSIPSVRPP---------KWLLGKTVLQAGGNVGLEQ 2429 Query: 1229 RGPQPRDEGFYSCSARS-----PLGQANTSLELRLEGVRVILAPEAAVPEGAPI-TVTCA 1282 G R +CS + +G++ +S L + + V+L G + +V + Sbjct: 2430 EGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPLEPKTGRELQSVVLS 2489 Query: 1283 DPAAHAPTLYTWYHNGRWLQ---------EGPAASLSFLVATRAHAGAYSCQAQDAQGTR 1333 AP WY + L EG A L L A AG Y CQA A + Sbjct: 2490 CDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHSST 2549 Query: 1334 SSRPAALQVLYAPQDAVLSSFRDSRA--RSMAVIQCTVDSEPPAELALSHDGKVLATSSG 1391 A +V V +D+ A A C + E E+ S +G L S Sbjct: 2550 EVTVEAREV------TVTGPLQDAEATEEGWASFSCELSHE-DEEVEWSLNGMPLYNDSF 2602 Query: 1392 VHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEP 1451 G H V ++ R D + A +L +ST RL+V VV Sbjct: 2603 HEISHKGRRHTLVLKSIQRA---------DAGIVRASSL--KVSTSARLEVRVKPVVFLK 2651 Query: 1452 GLD---VPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQ--- 1505 LD E L L C + V W + P F H A + Sbjct: 2652 ALDDLSAEERGTLALQCEVSDPEAHV-------VWRKDGVQLGPSDKYDFLHTAGTRGLV 2704 Query: 1506 --------AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVD 1557 AG+Y C A L V + TM V +L Sbjct: 2705 VHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHESA 2764 Query: 1558 SEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASN 1617 S+P A T +G + V SS A + ++L + PSD GE + S Sbjct: 2765 SDP-AMWT--VGGKTVGSSSRFQATRQGRKYILV--------VREAAPSDAGEVVFSVRG 2813 Query: 1618 VLGSAS 1623 + AS Sbjct: 2814 LTSKAS 2819 Score = 68.9 bits (167), Expect = 4e-11 Identities = 266/1211 (21%), Positives = 410/1211 (33%), Gaps = 218/1211 (18%) Query: 509 NAARLLISPAAEVV----------EGQAVTLSCRSGLSPTPDARFSWYLNGALLH----- 553 ++ARL++S V+ E Q+V LSC P P A WY + L Sbjct: 2458 SSARLVVSDIPVVLTRPLEPKTGRELQSVVLSC--DFRPAPKA-VQWYKDDTPLSPSEKF 2514 Query: 554 ----EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDL 609 EG + L + DAG Y C+A HS++ V R+ T T L Sbjct: 2515 KMSLEGQMAELRILRLMPADAGVYRCQAGSAHSST--------EVTVEAREVTVTGPLQ- 2565 Query: 610 DAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAP 669 DA G +L H+D V SL G + Sbjct: 2566 DAEATEEGWASF-----------SCELSHEDEEVEWSL---NGMPLYNDSFHEISHKGRR 2611 Query: 670 NLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTC 729 + L ++ + + G+ + +A + A+ + GT A L C Sbjct: 2612 HTLVLK--SIQRADAGIVRASSLKVSTSARLEVRVKPVVFLKALDDLSAEERGTLA-LQC 2668 Query: 730 NVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVART-----------DAALYACRILT 778 VS A+ W ++GV GP + L A T DA LY C + + Sbjct: 2669 EVS----DPEAHVVWRKDGV--QLGPSDKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGS 2722 Query: 779 EAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLAT 838 E + V + L+ +L + ++ +G F C + + A++ T Sbjct: 2723 E---ETRARVRVHDLHVGITKRLKTM-EVLEGESCSFECVLSHESASDPAMW-------T 2771 Query: 839 SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV 898 G V S RFQA + L VRE D+G + +S SL + R A + Sbjct: 2772 VGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGEVVFSVRGL--TSKASLIVRERPAAI 2829 Query: 899 QVSPSPE--LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQ---------ESTSATLRF 947 + P + + G+ V L C++ GT W +D + ++ E T A L Sbjct: 2830 -IKPLEDQWVAPGEDVELRCELSRA---GTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVI 2885 Query: 948 AAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVT--LTTLMDTGPGRLGLLLC 1005 +L AG Y C+ +A S SLHV T LT L G + C Sbjct: 2886 RGASLKDAGEYTCEVEASKSTA-------SLHVEEKANCFTEELTNLQVEEKG-TAVFTC 2937 Query: 1006 RVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVY 1065 + + P A + G L+ G + S L TLRL I D Y Sbjct: 2938 KTE-HPAATVTWRKG----LLELRASGKHQPSQEGL-------TLRLTISALEKADSDTY 2985 Query: 1066 ICEASNTLGQASASADFDAQAVNVQV---WPGATVREGQLVNLTCLVWTTHPAQL-TYTW 1121 C+ +GQA + A Q V + V+EG C + PA W Sbjct: 2986 TCD----IGQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSATFRCRI---SPANYEPVHW 3038 Query: 1122 YQDGQ-------QRLDA-----HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVL 1169 + D +DA H + L + ++D+ + G R S + + Sbjct: 3039 FLDKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEAGD----QRASAALRVTEK 3094 Query: 1170 YAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVP---NTLRL 1226 + + LT + G L LV T P + + G+ L S + + +L Sbjct: 3095 PSVFSRELTDATITEGEDLTLVCETSTCDIP--VCWTKDGKTLRGSARCQLSHEGHRAQL 3152 Query: 1227 ELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAA 1286 + G +D G Y C A + + R + L + V EG T+ C + Sbjct: 3153 LITGATLQDSGRYKCEAGGACSSSIVRVHARPVRFQEAL-KDLEVLEGGAATLRCVLSSV 3211 Query: 1287 HAPTLYTWYHN-------GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAA 1339 AP + + +N QEG L +G YSC D + A Sbjct: 3212 AAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSFGD-----QTTSAT 3266 Query: 1340 LQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLAS 1397 L V P + R+ A + A ++C + P E G +L Sbjct: 3267 LTVTALPAQ-FIGKLRNKEATEGATATLRCELSKAAPVE-----------WRKGSETLRD 3314 Query: 1398 GTGHVQVARNAL-RLQVQD---VPAGDDTYVCTAQNLLGSIST-------IGRLQVEGAR 1446 G + A+ LQ++ V A + + VC + S++ IGRL+ + Sbjct: 3315 GDRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFIGRLRHQ--- 3371 Query: 1447 VVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA----EPVPTLAFTHVA 1502 + EGA L C L PV D H+ V L +A Sbjct: 3372 -------ESIEGATATLRCE-LSKAAPVEWRKGRESLRDGDRHSLRQDGAVCELQICGLA 3423 Query: 1503 RAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLA 1562 A AG Y C+ G ++ + P K + E G +L C + +A Sbjct: 3424 VADAGEYSCVC----GEERTSATLTVKALPAKFTEGLRNEEAVEGATAMLWCELSK--VA 3477 Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622 + G P+ + + I L +D GEY+C V G Sbjct: 3478 PVEWRKG--------PENLRDGDRYILRQEGTRCELQICGLAMADAGEYLC----VCGQE 3525 Query: 1623 STSTYFGVRAL 1633 TS +RAL Sbjct: 3526 RTSATLTIRAL 3536 Score = 67.8 bits (164), Expect = 9e-11 Identities = 122/500 (24%), Positives = 189/500 (37%), Gaps = 80/500 (16%) Query: 138 EPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVG 197 EP+V A + + ST C Q + + + ++F+S K VG Sbjct: 1437 EPKV-VFAKEQPVHREVQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSFSS-KVRMEAVG 1494 Query: 198 HLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILP--G 255 L + Q G+ + + S + HL V PK V P+ R + G Sbjct: 1495 CTRRLVV----QQAGQAVAGEYSCEAGSQRLSFHLHVA-EPKAVFAKEQPASREVQAEAG 1549 Query: 256 ELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTC 305 TL+C+V A + + W KDG +L + + V L + +A +DAG Y+C Sbjct: 1550 TSATLSCEVAQ---AQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSC 1606 Query: 306 QAENGVGSLVSPPISLHIFMAEVQV-----SPAGPILENQ---TVTLVCNTPNEAPSDLR 357 +A + +S H+ +AE +V PA ++ + + TL C A + Sbjct: 1607 KAGD-------QRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEV---AQAQTE 1656 Query: 358 YSWYKNHVLLEDAH---------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVV 408 +WYK+ L + + L + A +AD G Y CE G +R +S + Sbjct: 1657 VTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQR---LSFRL 1709 Query: 409 NHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSG-DSDHSPRFSG 467 + L P ++ + LV H ++ ATL + G + S R Sbjct: 1710 HVAELEPQISERPCRREPLVVKEHEDIILT--ATLATPSAATVTWLKDGVEIRRSKRHET 1767 Query: 468 TSGPNSLRLEIRDLEETDSGEYKCSA-TNSLGNATSTLDFHANAARLLISPAAEVVEGQA 526 S ++ L + + DS Y C + A RLL E+ G Sbjct: 1768 ASQGDTHTLTVHGAQVLDSAIYSCRVGAEGQDFPVQVEEVAAKFCRLLEPVCGEL--GGT 1825 Query: 527 VTLSCRSGLSPTPDARFSWYLNGALLH---------EGPGSSLLLPAASSTDAGSYHCRA 577 VTL+C LSP A W L EGP SL + + DAG Y C + Sbjct: 1826 VTLACE--LSPAC-AEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCES 1882 Query: 578 RDGHSASGPSSPAVLTVLYP 597 RD H++ A LTV P Sbjct: 1883 RDDHTS------AQLTVSVP 1896 Score = 58.5 bits (140), Expect = 5e-08 Identities = 219/971 (22%), Positives = 342/971 (35%), Gaps = 172/971 (17%) Query: 172 RLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIH 231 R Q + P RS+T + E G ++ S DH QL+V+ Sbjct: 1853 RFQMVAEGPVRSLTVLGLRAEDAGE------YVCESRDDH---TSAQLTVS--------- 1894 Query: 232 LQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ------- 284 P+ VK + S G T C V+ P+ ++ W +DG LQ Sbjct: 1895 -----VPRVVKFMSGLSTVVAEEGGEATFQCVVS---PSDVAVVWFRDGALLQPSEKFAI 1946 Query: 285 TKTGVLH---LPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQT 341 +++G H + DAG T +AE G S + + + + ++ P + E + Sbjct: 1947 SQSGASHSLTISDLVLEDAGQITVEAE-GASSSAALRVREAPVLFKKKLEPQ-TVEERSS 2004 Query: 342 VTLVCNTPNEAPSDLRYSWY-------KNHVLLEDAHSHTLRLHLATRADTGFYFCEVQN 394 VTL P +LR++ KN + + H L LH AD GF+ CE + Sbjct: 2005 VTLEVELTRPWP-ELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCETPD 2063 Query: 395 VHGSERSGPVSVVVNHPPLTPVLTAFLETQAGL----VGILHCSVVSEPLATLVLSHGGH 450 + ++V + L L A + G V + H V + G Sbjct: 2064 ---DKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQLSHADVDGS------WTRDG- 2113 Query: 451 ILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG--EYKCSATNSLGNATSTLDFHA 508 L G + H GP L + L DSG +K ++ T + Sbjct: 2114 -LRFQQGPTCHL----AVRGPMHT-LTLSGLRPEDSGLMVFKAEGVHTSARLVVT-ELPV 2166 Query: 509 NAARLLISPAAEVV--EGQAVTLSCRSGLSPTPDARFSWYLNG---------ALLHEGPG 557 + +R P +VV E + VTL C P D R W +G A+ +G Sbjct: 2167 SFSR----PLQDVVTTEKEKVTLECELS-RPNVDVR--WLKDGVELRAGKTMAIAAQGAC 2219 Query: 558 SSLLLPAASSTDAGSYHCRARDGHS-ASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGA 616 SL + D G Y C A D S AS T++Y R+ ++ A Sbjct: 2220 RSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIY--RRVLAEDAGEIQFVAENA 2277 Query: 617 GRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCS--------------PR 662 R L RV P ++ L +D++ C + P+ Sbjct: 2278 ESRAQL--RVKELPVTLVRPL-RDKIAMEKHRGVLECQVSRASAQVRWFKGSQELQPGPK 2334 Query: 663 MKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATF---NGQATVLAIAPSHTL 719 ++ ++ I + E+E Y C+A G+ TSA F T++ T+ Sbjct: 2335 YELVSDGLYRKLIISDVHAEDEDTYTCDA----GDVKTSAQFFVEEQSITIVRGLQDVTV 2390 Query: 720 QEGTEANLTCNVSREAAGSPANFSWFRNG-VLWAQGPLE-----TVTLLPVARTDAALYA 773 E A C S + P W VL A G + TV L + RT + + Sbjct: 2391 MEPAPAWFECETSIPSVRPP---KWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTG 2447 Query: 774 CRILTEAGAQLSTPVLLS----VLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLAL 829 T ++ S +++S VL P PK L + + D RP Sbjct: 2448 PVHFTVGKSRSSARLVVSDIPVVLTRPLEPKTGRELQS-------VVLSCDFRPAPKAVQ 2500 Query: 830 FHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSL 889 ++ + P PS +F+ E +L + L D+G YRC+A GS+++S Sbjct: 2501 WYKDDT------PLSPSE-KFKMSLEGQMAELRILRLMPADAGVYRCQA----GSAHSST 2549 Query: 890 FFQVRGAWVQVSPSPELQEGQA-----VVLSCQVHTGVPEGTSYRWYRDGQPLQEST--S 942 V +V+ + LQ+ +A SC++ E W +G PL + Sbjct: 2550 EVTVEAR--EVTVTGPLQDAEATEEGWASFSCELS---HEDEEVEWSLNGMPLYNDSFHE 2604 Query: 943 ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL 1002 + + TL A +++ ++ L V P V L L D G Sbjct: 2605 ISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKP-VVFLKALDDLSAEERGT 2663 Query: 1003 LLCRVD-SDPPAQLRLLHGDRLVASTLQGVG-GPEGSSPRLHVAVAPNTLRLEIHGAMLE 1060 L + + SDP A V GV GP LH A T L +H E Sbjct: 2664 LALQCEVSDPEAH---------VVWRKDGVQLGPSDKYDFLHTA---GTRGLVVHDVSPE 2711 Query: 1061 DEGVYICEASN 1071 D G+Y C + Sbjct: 2712 DAGLYTCHVGS 2722 Score = 57.8 bits (138), Expect = 9e-08 Identities = 79/348 (22%), Positives = 119/348 (34%), Gaps = 82/348 (23%) Query: 1339 ALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASG 1398 A + L P+ V+S +D A + C + P +++ D + +A + G Sbjct: 9 APRFLTRPKAFVVSVGKD------ATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDG 62 Query: 1399 TGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQVEGARVVAEPG----- 1452 + RL + D+ GD YVC A+N +G LQV+ AE Sbjct: 63 --------DLYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLL 114 Query: 1453 ----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQA-- 1506 + V EG+ CR+ G P P +W + RRL P + + A A Sbjct: 115 RPTSIRVREGSEATFRCRVGGSPRPA----VSWSKDGRRLGEPDGPRVRVEELGEASALR 170 Query: 1507 ---------GMYHCLAELPTGAAASAPVML------------------------------ 1527 G Y AE P GAA++A ++ Sbjct: 171 IRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAM 230 Query: 1528 ----RVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPA 1583 PP T T V G L C V EP +LV + Sbjct: 231 RAEGAPASPPSTGTRTCTVTE--GKHARLSCYVTGEPKPETVWKKDGQLVTEGR------ 282 Query: 1584 EPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631 H+ + + I + SD+G Y C+ASN++G +S VR Sbjct: 283 -RHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVR 329 Score = 54.3 bits (129), Expect = 1e-06 Identities = 54/192 (28%), Positives = 78/192 (40%), Gaps = 24/192 (12%) Query: 909 GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST----------SATLRFAAITLTQAGAY 958 G+ V L+C+V TG P+ WY+DG+ +Q S L ++T +G Y Sbjct: 6028 GETVKLACRV-TGTPKPV-ISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQY 6085 Query: 959 HCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLL 1018 C A + ++L + V PR V G C ++ P Q+R Sbjct: 6086 MCFAASAAGNCSTLG---KILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWY 6142 Query: 1019 HGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASA 1078 L+ + G S PR + V L I A ED G+Y CE N LG A A Sbjct: 6143 KDGALLTT---GNKFQTLSEPRSGLLV------LVIRAASKEDLGLYECELVNRLGSARA 6193 Query: 1079 SADFDAQAVNVQ 1090 SA+ Q+ +Q Sbjct: 6194 SAELRIQSPMLQ 6205 Score = 49.3 bits (116), Expect = 3e-05 Identities = 57/198 (28%), Positives = 86/198 (43%), Gaps = 31/198 (15%) Query: 524 GQAVTLSCRSGLSPTPDARFSWYLNGA--------LLHEGPGSS--LLLPAASSTDAGSY 573 G+ V L+CR ++ TP SWY +G +L E P S L+L + + D+G Y Sbjct: 6028 GETVKLACR--VTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQY 6085 Query: 574 HCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPAR 633 C A +A S+ + V PPR F ++ A+ G C ++ P + Sbjct: 6086 MCFAAS--AAGNCSTLGKILVQVPPR---FVNKVR--ASPFVEGEDAQFTCTIEGAPYPQ 6138 Query: 634 LQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASN 693 ++ +KD + T+ G T PR LL + I E+ GLY CE N Sbjct: 6139 IRW-YKDGALLTT---GNKFQTLS--EPRS------GLLVLVIRAASKEDLGLYECELVN 6186 Query: 694 ALGNASTSATFNGQATVL 711 LG+A SA Q+ +L Sbjct: 6187 RLGSARASAELRIQSPML 6204 Score = 47.0 bits (110), Expect = 2e-04 Identities = 96/460 (20%), Positives = 154/460 (33%), Gaps = 82/460 (17%) Query: 718 TLQEGTEANLTCNVSREAAGSPAN-FSWFRNGVLWAQGPLETVTLLP----------VAR 766 T + G L C V+ G+P SW+++G P + P + Sbjct: 6024 TAELGETVKLACRVT----GTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTG 6079 Query: 767 TDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLAL 826 D+ Y C + AG ST + V PP +G A F CT++ P Sbjct: 6080 VDSGQYMCFAASAAG-NCSTLGKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQ 6138 Query: 827 LALFHGEHLLATSLGPQVPSHGRFQAKAEANS--LKLEVRELGLGDSGSYRCEATNVLGS 884 + + LL T +FQ +E S L L +R D G Y CE N LGS Sbjct: 6139 IRWYKDGALLTTG--------NKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGS 6190 Query: 885 SNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT 944 + S +++ +Q ++ A V + E TS G ++ Sbjct: 6191 ARASAELRIQSPMLQAQEQCHREQLVAAVEDTTLERADQEVTSVLKRLLGPKAPGPSTGD 6250 Query: 945 LRFAAITLTQAGAYHCQAQAPGSATTSLAAPI--SLHVSYAPRHVTLTTLMDTGPGRLGL 1002 L G C AP T P+ + P V L+ GP Sbjct: 6251 L---------TGPGPCPRGAPALQETGSQPPVTGTSEAPAVPPRVP-QPLLHEGP----- 6295 Query: 1003 LLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED- 1061 + +P A R + V ++G P L ++H ++ + Sbjct: 6296 -----EQEPEAIARA--QEWTVPIRMEGAAWP---------GAGTGELLWDVHSHVVRET 6339 Query: 1062 -EGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYT 1120 + Y +A +T + +VQ G T + ++ Q + T Sbjct: 6340 TQRTYTYQAIDT--HTARPPSMQVTIEDVQAQTGGTAQFEAIIE--------GDPQPSVT 6389 Query: 1121 WYQDGQQRLDA-----------HSIPLPNVTVRDATSYRC 1149 WY+D Q +D+ +S+ L +V +DA Y C Sbjct: 6390 WYKDSVQLVDSTRLSQQQEGTTYSLVLRHVASKDAGVYTC 6429 Score = 46.6 bits (109), Expect = 2e-04 Identities = 49/182 (26%), Positives = 72/182 (39%), Gaps = 23/182 (12%) Query: 1096 TVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ-RLDAHSIP-----------LPNVTVRD 1143 T G+ V L C V T + +WY+DG+ ++D H I L ++T D Sbjct: 6024 TAELGETVKLACRV--TGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVD 6081 Query: 1144 ATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQ 1202 + Y C G L + + V PR + G+ A CT++ P Q Sbjct: 6082 SGQYMCFAASAAGNCSTLGKIL---VQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQ 6138 Query: 1203 LALSHAGRLLASST---AASVPNT--LRLELRGPQPRDEGFYSCSARSPLGQANTSLELR 1257 + G LL + S P + L L +R D G Y C + LG A S ELR Sbjct: 6139 IRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELR 6198 Query: 1258 LE 1259 ++ Sbjct: 6199 IQ 6200 Score = 40.8 bits (94), Expect = 0.011 Identities = 49/186 (26%), Positives = 73/186 (39%), Gaps = 22/186 (11%) Query: 340 QTVTLVCNTPNEAPSDLRYSWYKN---------HVLLEDAH-SHTLRLHLATRADTGFYF 389 +TV L C + SWYK+ H+L+ED S L L T D+G Y Sbjct: 6029 ETVKLACRVTGTPKPVI--SWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYM 6086 Query: 390 CEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGG 449 C + G+ S ++V PP G C++ P + G Sbjct: 6087 CFAASAAGN-CSTLGKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDG 6145 Query: 450 HILASTSGDSDHSPRFSGTSGPNS--LRLEIRDLEETDSGEYKCSATNSLGNATSTLDFH 507 +L T+G+ +F S P S L L IR + D G Y+C N LG+A ++ + Sbjct: 6146 ALL--TTGN-----KFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELR 6198 Query: 508 ANAARL 513 + L Sbjct: 6199 IQSPML 6204 Score = 40.0 bits (92), Expect = 0.019 Identities = 88/430 (20%), Positives = 139/430 (32%), Gaps = 101/430 (23%) Query: 639 KDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEE-------------- 684 +++ V P C G P ++ K LL + H + E++ Sbjct: 5133 QNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPA 5192 Query: 685 --GLYLCEASNALGNASTSATFNGQAT-----VLAIAP------------SHTLQEGTEA 725 G+Y C A N++G +ST A T A A S QEGTE+ Sbjct: 5193 DMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTES 5252 Query: 726 NLT----------------------CNVSREAAGSPA-NFSWFRNGV---------LWAQ 753 + G PA WF++G + + Sbjct: 5253 TTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDK 5312 Query: 754 GPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQ---- 809 L T+ ++ V R D+ YA I GA S+ LL + PD P+ D+ + Sbjct: 5313 KILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLL--VRGPDEPEEKPASDVHEQLVP 5370 Query: 810 --------------GHMALFICTVDSRPLALLALFHGEHLLATS-LGPQVPSHGRFQAKA 854 G F V+ RP+ + E +GP P + + Sbjct: 5371 PRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPG---YTVAS 5427 Query: 855 EANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVL 914 A L + ++G G+Y C A+N G + S V G P E QE L Sbjct: 5428 SAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGL-----PKVEEQEKVKEAL 5482 Query: 915 SCQVHTGVPEGTSYRWYR-------DGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGS 967 G + S + GQ +E +A ++L + G + Sbjct: 5483 ISTFLQGTTQAISAQGLETASFADLGGQRKEEPLAAKEALGHLSLAEVGTEEFLQKLTSQ 5542 Query: 968 ATTSLAAPIS 977 T ++A I+ Sbjct: 5543 ITEMVSAKIT 5552 Score = 40.0 bits (92), Expect = 0.019 Identities = 42/188 (22%), Positives = 70/188 (37%), Gaps = 27/188 (14%) Query: 1458 GAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVP----------TLAFTHVARAQAG 1507 G + L+CR+ G P PV +W+ + + + +P L + +G Sbjct: 6028 GETVKLACRVTGTPKPV----ISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSG 6083 Query: 1508 MYHCLAELPTGAAASAPVMLRVLYPPKTPTMM---VFVEPEGGLRGILDCRVDSEPLASL 1564 Y C A G ++ +L V PP+ + FVE E C ++ P + Sbjct: 6084 QYMCFAASAAGNCSTLGKIL-VQVPPRFVNKVRASPFVEGEDAQ---FTCTIEGAPYPQI 6139 Query: 1565 TLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSAST 1624 + L+ + +EP +L + I A D G Y C N LGSA Sbjct: 6140 RWYKDGALLTTGNKFQTLSEPRSGLLV------LVIRAASKEDLGLYECELVNRLGSARA 6193 Query: 1625 STYFGVRA 1632 S +++ Sbjct: 6194 SAELRIQS 6201 Score = 40.0 bits (92), Expect = 0.019 Identities = 26/80 (32%), Positives = 39/80 (48%), Gaps = 13/80 (16%) Query: 248 SGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVL-----------HLPQAA 296 S ++ G+ VTL CQV S+ PA + W KDG L++ + VL + Sbjct: 7470 SDETVVLGQSVTLACQV-SAQPAAQAT-WSKDGAPLESSSRVLISATLKNFQLLTILVVV 7527 Query: 297 WSDAGVYTCQAENGVGSLVS 316 D GVYTC N +G++ + Sbjct: 7528 AEDLGVYTCSVSNALGTVTT 7547 Score = 37.4 bits (85), Expect = 0.13 Identities = 31/94 (32%), Positives = 46/94 (48%), Gaps = 9/94 (9%) Query: 1365 IQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGD-DTY 1423 + C V ++P A+ S DG L +SS V L S T +N L + V A D Y Sbjct: 7482 LACQVSAQPAAQATWSKDGAPLESSSRV--LISAT-----LKNFQLLTILVVVAEDLGVY 7534 Query: 1424 VCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPE 1457 C+ N LG+++T G L+ + R + P D+ E Sbjct: 7535 TCSVSNALGTVTTTGVLR-KAERPSSSPCPDIGE 7567 Score = 36.6 bits (83), Expect = 0.21 Identities = 25/76 (32%), Positives = 35/76 (46%), Gaps = 4/76 (5%) Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLR----LELRGPQPRDEGFYSC 1241 GQ + C V ++P AQ S G L SS+ + TL+ L + D G Y+C Sbjct: 7477 GQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLTILVVVAEDLGVYTC 7536 Query: 1242 SARSPLGQANTSLELR 1257 S + LG T+ LR Sbjct: 7537 SVSNALGTVTTTGVLR 7552 Score = 36.2 bits (82), Expect = 0.28 Identities = 42/191 (21%), Positives = 75/191 (39%), Gaps = 25/191 (13%) Query: 1274 GAPITVTCADPAAHAPTLYTWYHNGRWLQ--------EGPAASLSFLV--ATRAHAGAYS 1323 G + + C P + +WY +G+ +Q E P S + ++ T +G Y Sbjct: 6028 GETVKLACRVTGTPKPVI-SWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYM 6086 Query: 1324 CQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSR--ARSMAVIQCTVDSEPPAELALSH 1381 C A A G S+ ++L ++ R S A CT++ P ++ Sbjct: 6087 CFAASAAGNCSTLG---KILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYK 6143 Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD--TYVCTAQNLLGSISTIGR 1439 DG +L T + +L+ R+ L + V + +D Y C N LGS Sbjct: 6144 DGALLTTGNKFQTLSE-------PRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAE 6196 Query: 1440 LQVEGARVVAE 1450 L+++ + A+ Sbjct: 6197 LRIQSPMLQAQ 6207 Score = 34.3 bits (77), Expect = 1.1 Identities = 74/336 (22%), Positives = 111/336 (33%), Gaps = 73/336 (21%) Query: 520 EVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP----------GSSLLLPAASSTD 569 EV +G V+ C P P R W+ +G LL E G L++ A D Sbjct: 5136 EVQDGYPVSFDCVVTGQPMPSVR--WFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPAD 5193 Query: 570 AGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRV--- 626 G Y C A + S S+ A L V + T D + + +G L R Sbjct: 5194 MGVYRCLAENSMGVS--STKAELRV--DLTSTDYDTAADATESSSYFSAQGYLSSREQEG 5249 Query: 627 ------DSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRM---------------KV 665 + P ++ L +V + + G +PR+ ++ Sbjct: 5250 TESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRM 5309 Query: 666 TKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATF-----------NGQATVLAIA 714 T L +EI + E+ G Y SNA+G A +SA + Sbjct: 5310 TDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLV 5369 Query: 715 PSHTLQEGTE------ANLTCNVSREAAGSPANFSWFR----NGVLW-----------AQ 753 P L+ T +++T +V E P W R GVLW + Sbjct: 5370 PPRMLERFTPKKVKKGSSITFSVKVEGRPVP-TVHWLREEAERGVLWIGPDTPGYTVASS 5428 Query: 754 GPLETVTLLPVARTDAALYACRILTEAGAQLSTPVL 789 ++ LL V R Y C AG L + L Sbjct: 5429 AQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASL 5464 Score = 33.5 bits (75), Expect = 1.8 Identities = 74/337 (21%), Positives = 114/337 (33%), Gaps = 79/337 (23%) Query: 255 GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAA------------WSDAGV 302 G+ + L C V S A +WLKDGV L T H+ Q +DAG Sbjct: 4912 GDALRLECVVASK--ADVRARWLKDGVEL-TDGRHHHIDQLGDGTCSLLITGLDRADAGC 4968 Query: 303 YTCQAENGVGSLV-SPPISLHIFMAEVQVSPAG-----------------------PILE 338 YTCQ N G + S + + +E + S G + + Sbjct: 4969 YTCQVSNKFGQVTHSACVVVSGSESEAESSSGGELDDAFRRAARRLHRLFRTKSPAEVSD 5028 Query: 339 NQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRA-----------DTGF 387 + P E + Y+ ED H +R T A T Sbjct: 5029 EELFLSADEGPAEPEEPADWQTYR-----EDEHFICIRFEALTEARQAVTRFQEMFATLG 5083 Query: 388 YFCEVQNVHGSERSGPVSV-------VVNHPPLTPVLTA-----FL------ETQAGLVG 429 E++ V R + + VV PL +LT+ FL E Q G Sbjct: 5084 IGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPV 5143 Query: 430 ILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEY 489 C V +P+ ++ G +L + DH G + +L I + D G Y Sbjct: 5144 SFDCVVTGQPMPSVRWFKDGKLLE----EDDHYMINEDQQGGH--QLIITAVVPADMGVY 5197 Query: 490 KCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQA 526 +C A NS+G +++ + + AA+ E + Sbjct: 5198 RCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSS 5234 Score = 33.5 bits (75), Expect = 1.8 Identities = 25/77 (32%), Positives = 33/77 (42%), Gaps = 13/77 (16%) Query: 1552 LDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASP---NALRVDIEALRPSDQ 1608 L C+V ++P A T GAP E VL S N + I + D Sbjct: 7482 LACQVSAQPAAQATW----------SKDGAPLESSSRVLISATLKNFQLLTILVVVAEDL 7531 Query: 1609 GEYICSASNVLGSASTS 1625 G Y CS SN LG+ +T+ Sbjct: 7532 GVYTCSVSNALGTVTTT 7548 Score = 33.1 bits (74), Expect = 2.4 Identities = 30/94 (31%), Positives = 44/94 (46%), Gaps = 21/94 (22%) Query: 234 VKYAPKGV-KILLSPSGRNILPGELVTLTCQVNSS-YPAVSSIKWLKDGVRLQT------ 285 V+ P+ V K+ SP + GE TC + + YP I+W KDG L T Sbjct: 6104 VQVPPRFVNKVRASP----FVEGEDAQFTCTIEGAPYP---QIRWYKDGALLTTGNKFQT 6156 Query: 286 ----KTG--VLHLPQAAWSDAGVYTCQAENGVGS 313 ++G VL + A+ D G+Y C+ N +GS Sbjct: 6157 LSEPRSGLLVLVIRAASKEDLGLYECELVNRLGS 6190 Score = 33.1 bits (74), Expect = 2.4 Identities = 20/53 (37%), Positives = 26/53 (49%), Gaps = 10/53 (18%) Query: 273 SIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTCQAENGVGSLV 315 S+ W KD V+L T + L L A DAGVYTC A+N G ++ Sbjct: 6387 SVTWYKDSVQLVDSTRLSQQQEGTTYSLVLRHVASKDAGVYTCLAQNTGGQVL 6439 Score = 33.1 bits (74), Expect = 2.4 Identities = 36/144 (25%), Positives = 55/144 (38%), Gaps = 27/144 (18%) Query: 681 LEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740 LE+EG + A S +++ T L T+ G L C VS + A A Sbjct: 7436 LEKEGPPRKKPGLASFRLSGLKSWDRAPTFLRELSDETVVLGQSVTLACQVSAQPA---A 7492 Query: 741 NFSWFRNGVLWAQGPLET---------------VTLLPVARTDAALYACRILTEAGAQLS 785 +W ++G PLE+ +T+L V D +Y C + G + Sbjct: 7493 QATWSKDGA-----PLESSSRVLISATLKNFQLLTILVVVAEDLGVYTCSVSNALGTVTT 7547 Query: 786 TPVLLSVLYPPDRPKLSALLDMGQ 809 T VL +RP S D+G+ Sbjct: 7548 T----GVLRKAERPSSSPCPDIGE 7567 >gi|98986445 carcinoembryonic antigen-related cell adhesion molecule 5 preproprotein [Homo sapiens] Length = 702 Score = 109 bits (272), Expect = 3e-23 Identities = 150/623 (24%), Positives = 231/623 (37%), Gaps = 114/623 (18%) Query: 335 PILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH-------SHTLRLHLATRADTGF 387 P+ + V C + D Y W+ N+ L + + TL L TR DT Sbjct: 156 PVEDKDAVAFTCEPETQ---DATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTAS 212 Query: 388 YFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF-LETQAGLVGILHCSVVSEPLATLVLS 446 Y CE QN + RS V + V + P P ++ ++G L C S P A Sbjct: 213 YKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPA----- 267 Query: 447 HGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNS---LGNAT-S 502 +S +GT ++ L I ++ +SG Y C A NS L T + Sbjct: 268 -------------QYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVT 314 Query: 503 TLDFHANAARLLISP--AAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP---- 556 T+ +A + I+ + V + AV L+C + T + W++N L P Sbjct: 315 TITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNT---TYLWWVNNQSLPVSPRLQL 371 Query: 557 ---GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAG 613 +L L + + D G Y C ++ S S P +L VLY P PT + G Sbjct: 372 SNDNRTLTLLSVTRNDVGPYECGIQNKLSVD-HSDPVILNVLYGPDDPTISPSYTYYRPG 430 Query: 614 AGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLR 673 L C S+PPA+ L + + Sbjct: 431 VNLS----LSCHAASNPPAQYSWLIDGNI-------------------------QQHTQE 461 Query: 674 VEIHNPLLEEEGLYLCEASN-ALGNASTSA---TFNGQATVLAIAPSHT--LQEGTEANL 727 + I N + GLY C+A+N A G++ T+ T + + +I+ +++ +++ Sbjct: 462 LFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAF 521 Query: 728 TCNVSREAAGSPANFSWFRNGVLWAQGPL-------ETVTLLPVARTDAALYACRILTEA 780 TC E + W+ NG P T+TL V R DA Y C I Sbjct: 522 TC----EPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSV 577 Query: 781 GAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSL 840 A S PV L VLY PD P I DS L+ L H ++ Sbjct: 578 SANRSDPVTLDVLYGPDTP---------------IISPPDSSYLSGANLNLSCH---SAS 619 Query: 841 GPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV 900 P R + ++ L + ++ ++G+Y C +N+ N S+ V+ V Sbjct: 620 NPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSI---VKSITVSA 676 Query: 901 S-PSPELQEGQAVVLSCQVHTGV 922 S SP L G V + V GV Sbjct: 677 SGTSPGLSAGATVGIMIGVLVGV 699 Score = 105 bits (263), Expect = 3e-22 Identities = 117/448 (26%), Positives = 182/448 (40%), Gaps = 86/448 (19%) Query: 758 TVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSAL-LDMGQGHMALFI 816 T+TL V R D A Y C A+ S V+L+VLY PD P +S L G Sbjct: 199 TLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLS 258 Query: 817 CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRC 876 C S P A + F +G FQ + +L + + + +SGSY C Sbjct: 259 CHAASNPPAQYSWF---------------VNGTFQQSTQ----ELFIPNITVNNSGSYTC 299 Query: 877 EATNV-LGSSNT-----SLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRW 930 +A N G + T +++ + ++ + S +++ AV L+C+ + T+Y W Sbjct: 300 QAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEI---QNTTYLW 356 Query: 931 YRDGQPLQES-------TSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYA 983 + + Q L S + TL ++T G Y C Q + + P+ L+V Y Sbjct: 357 WVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQ--NKLSVDHSDPVILNVLYG 414 Query: 984 PRHVTLT-TLMDTGPGRLGLLLCRVDSDPPAQLR-LLHGDRLVASTLQGVGGPEGSSPRL 1041 P T++ + PG L C S+PPAQ L+ G+ Sbjct: 415 PDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGN-------------------- 454 Query: 1042 HVAVAPNTLRLEIHGAMLEDEGVYICEASN--------TLGQASASADFDAQAVNVQVWP 1093 + +T L I ++ G+Y C+A+N T+ + SA+ +++ Sbjct: 455 ---IQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSN--N 509 Query: 1094 GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ-----RLDA----HSIPLPNVTVRDA 1144 V + V TC TY W+ +GQ RL ++ L NVT DA Sbjct: 510 SKPVEDKDAVAFTC---EPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDA 566 Query: 1145 TSYRCGVGPPGRAPRLSRPITLDVLYAP 1172 +Y CG+ A R S P+TLDVLY P Sbjct: 567 RAYVCGIQNSVSANR-SDPVTLDVLYGP 593 Score = 103 bits (258), Expect = 1e-21 Identities = 162/653 (24%), Positives = 234/653 (35%), Gaps = 119/653 (18%) Query: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA-SNTLGQASASADF 1082 V T Q GP S + + PN L I + D G Y + L A+ F Sbjct: 83 VIGTQQATPGPAYSGREI---IYPNASLL-IQNIIQNDTGFYTLHVIKSDLVNEEATGQF 138 Query: 1083 ----DAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ-----RLDA-- 1131 + ++ V + V TC T TY W+ + Q RL Sbjct: 139 RVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQ---DATYLWWVNNQSLPVSPRLQLSN 195 Query: 1132 --HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESH-GGQL 1188 ++ L NVT D SY+C P A R S + L+VLY P ++ L S+ G+ Sbjct: 196 GNRTLTLFNVTRNDTASYKCETQNPVSARR-SDSVILNVLYGPDAPTISPLNTSYRSGEN 254 Query: 1189 ALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLG 1248 + C S PPAQ + G S+ +PN + G Y+C A + Sbjct: 255 LNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNIT--------VNNSGSYTCQAHNSDT 306 Query: 1249 QAN----TSLELRLEGVRVILAPEAAVP--EGAPITVTCADPAAHAPTLYTWYHNGRWLQ 1302 N T++ + E + + + P + + +TC + T Y W+ N + L Sbjct: 307 GLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQN--TTYLWWVNNQSLP 364 Query: 1303 EGPAASLS-------FLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLS-SF 1354 P LS L TR G Y C Q+ S P L VLY P D +S S+ Sbjct: 365 VSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSY 424 Query: 1355 RDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQ 1414 R + C S PPA+ + DG + H+ ++ + L Sbjct: 425 TYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQ-----HTQELFISNITEKNSGL----- 474 Query: 1415 DVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAE---PGLD------VPEGAALNLSC 1465 Y C A N S S R V+ V AE P + V + A+ +C Sbjct: 475 --------YTCQANN---SASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTC 523 Query: 1466 RLLGGPGPVGNSTFAWFWNDRRLHAEP-------VPTLAFTHVARAQAGMYHCLAELPTG 1518 N+T+ W+ N + L P TL +V R A Y C + Sbjct: 524 E-----PEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVS 578 Query: 1519 AAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQP 1578 A S PV L VLY P TP + P DS L+ L+L ++ P Sbjct: 579 ANRSDPVTLDVLYGPDTP----IISPP-----------DSSYLSGANLNLSCHSASNPSP 623 Query: 1579 Q------GAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTS 1625 Q G P + H VL I + P++ G Y C SN+ + S Sbjct: 624 QYSWRINGIP-QQHTQVLF--------IAKITPNNNGTYACFVSNLATGRNNS 667 Score = 94.7 bits (234), Expect = 7e-19 Identities = 113/432 (26%), Positives = 173/432 (40%), Gaps = 60/432 (13%) Query: 225 RAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ 284 R + L V Y P I SP + GE + L+C S+ PA S W +G Q Sbjct: 224 RRSDSVILNVLYGPDAPTI--SPLNTSYRSGENLNLSCHAASNPPAQYS--WFVNGT-FQ 278 Query: 285 TKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAE-----VQVSPAGPILEN 339 T L +P +++G YTCQA N L ++ AE + + + P+ + Sbjct: 279 QSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDE 338 Query: 340 QTVTLVCNTPNEAPSDLRYSWYKNHVLLE-------DAHSHTLRLHLATRADTGFYFCEV 392 V L C + + Y W+ N+ L + TL L TR D G Y C + Sbjct: 339 DAVALTCEPEIQ---NTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGI 395 Query: 393 QNVHGSERSGPVSVVVNHPPLTPVLT-AFLETQAGLVGILHCSVVSEPLATLVLSHGGHI 451 QN + S PV + V + P P ++ ++ + G+ L C S P A Sbjct: 396 QNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPA---------- 445 Query: 452 LASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSL-GNATSTLDFHANA 510 +S G ++ L I ++ E +SG Y C A NS G++ +T+ + Sbjct: 446 --------QYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVS 497 Query: 511 ARL----LISPAAEVVEGQ-AVTLSCRSGLSPTPDARFSWYLNGALLHEGP-------GS 558 A L + S ++ VE + AV +C T + W++NG L P Sbjct: 498 AELPKPSISSNNSKPVEDKDAVAFTCEPEAQNT---TYLWWVNGQSLPVSPRLQLSNGNR 554 Query: 559 SLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGR 618 +L L + DA +Y C ++ SA+ S P L VLY P P + +GA Sbjct: 555 TLTLFNVTRNDARAYVCGIQNSVSAN-RSDPVTLDVLYGPDTPIISPPDSSYLSGANLN- 612 Query: 619 RGLLLCRVDSDP 630 L C S+P Sbjct: 613 ---LSCHSASNP 621 Score = 70.5 bits (171), Expect = 1e-11 Identities = 102/419 (24%), Positives = 168/419 (40%), Gaps = 66/419 (15%) Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIAS----PVELLEGTE 155 L + ++ +SGSY + S+ + T +TV EP P I S PVE + Sbjct: 284 LFIPNITVNNSGSYTCQAHNSDTGL-NRTTVTTITVYAEPPKPFITSNNSNPVE--DEDA 340 Query: 156 VDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRI- 214 V C +Q L W S + + + TL ++++ D G Sbjct: 341 VALTCEPE---IQNTTYLWWVNNQSLPV----SPRLQLSNDNRTLTL-LSVTRNDVGPYE 392 Query: 215 --LRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVS 272 ++ +LSV + + L V Y P I SPS PG ++L+C S+ PA Sbjct: 393 CGIQNKLSVDH---SDPVILNVLYGPDDPTI--SPSYTYYRPGVNLSLSCHAASNPPAQY 447 Query: 273 SIKWLKDGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGVG-----SLVSPPISLHIFMAE 327 S WL DG +Q T L + ++G+YTCQA N ++ + +S + Sbjct: 448 S--WLIDG-NIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPS 504 Query: 328 VQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH-------SHTLRLHLA 380 + + + P+ + V C + + Y W+ N L + + TL L Sbjct: 505 ISSNNSKPVEDKDAVAFTCEPEAQ---NTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNV 561 Query: 381 TRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPL 440 TR D Y C +QN + RS PV++ V + P TP+++ P Sbjct: 562 TRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--------------------PP 601 Query: 441 ATLVLSHGGHILASTSGDSDHSPRFS----GTSGPNSLRLEIRDLEETDSGEYKCSATN 495 + LS G ++ S S+ SP++S G ++ L I + ++G Y C +N Sbjct: 602 DSSYLS-GANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSN 659 Score = 52.8 bits (125), Expect = 3e-06 Identities = 113/538 (21%), Positives = 194/538 (36%), Gaps = 82/538 (15%) Query: 660 SPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG-NASTSATFNGQ--ATVLAIAPS 716 SPR++++ L + N + Y CE N + S S N I+P Sbjct: 188 SPRLQLSNGNRTLT--LFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPL 245 Query: 717 HT-LQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACR 775 +T + G NL+C+ A+ PA +SWF NG Q + + + + ++ Y C+ Sbjct: 246 NTSYRSGENLNLSCHA---ASNPPAQYSWFVNGTF--QQSTQELFIPNITVNNSGSYTCQ 300 Query: 776 I-LTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEH 834 ++ G +T ++V P +P FI + +S P+ E Sbjct: 301 AHNSDTGLNRTTVTTITVYAEPPKP---------------FITSNNSNPV------EDED 339 Query: 835 LLATSLGPQV--------------PSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATN 880 +A + P++ P R Q + +L L + D G Y C N Sbjct: 340 AVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTL--LSVTRNDVGPYECGIQN 397 Query: 881 VLGSSNTS-LFFQVRGAWVQVSPSPE---LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP 936 L ++ + V + SP + G + LSC + P Y W DG Sbjct: 398 KLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPP--AQYSWLIDGN- 454 Query: 937 LQESTSATLRFAAITLTQAGAYHCQA--QAPGSATTSLAAPISLHVSYAPRHVTLTTLMD 994 +Q+ T L + IT +G Y CQA A G + T++ I++ ++ Sbjct: 455 IQQHTQ-ELFISNITEKNSGLYTCQANNSASGHSRTTVKT-ITVSAELPKPSISSNNSKP 512 Query: 995 TGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEI 1054 C ++ L ++G L SPRL ++ TL L Sbjct: 513 VEDKDAVAFTCEPEAQNTTYLWWVNGQSLPV------------SPRLQLSNGNRTLTL-- 558 Query: 1055 HGAMLEDEGVYICEASNTL-GQASASADFD---AQAVNVQVWPGATVREGQLVNLTCLVW 1110 D Y+C N++ S D + P ++ G +NL+C Sbjct: 559 FNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSA 618 Query: 1111 TTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVG--PPGRAPRLSRPITL 1166 + Q Y+W +G + + + +T + +Y C V GR + + IT+ Sbjct: 619 SNPSPQ--YSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITV 674 >gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Homo sapiens] Length = 698 Score = 108 bits (269), Expect = 6e-23 Identities = 135/531 (25%), Positives = 217/531 (40%), Gaps = 80/531 (15%) Query: 5 PKLLLLASFFPAGQA-------SWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITA 57 P++LLL P A S+ + + V +G C+++ C S+P D D TA Sbjct: 11 PEMLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDGW--DESTA 68 Query: 58 IWYYDYSGQRQV-----VSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGS 112 + Y + G+ V+ + + VE R R + G+P C+L+++D Q ED Sbjct: 69 AYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAW 128 Query: 113 YNFRFEISEVNRWSDVKGT-LVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQV 171 Y FR E R S + + VT + P + P L G V C Sbjct: 129 YFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTVICV---------- 178 Query: 172 RLQWQGQD-PARSVTFNSQKFEP----TGVGHLETLHMAMSWQDHGRILRCQLSVANH-- 224 W + PA S ++ P H L S QDH L C + + Sbjct: 179 -FNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGV 237 Query: 225 RAQSEIHLQVKYAPKGVKILLSPSGRNIL------------PGELVTLTCQVNSSYPAVS 272 AQ + L+V YAPK + I +S + L G+ + L C +S PA Sbjct: 238 SAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPA-- 295 Query: 273 SIKW-LKDGVRLQT-----KTGVLHLPQAAWSDAGVYTCQAENGVG--------SLVSPP 318 ++ W L+D V + +T L L D+G YTC+AEN +G S+ PP Sbjct: 296 TLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPP 355 Query: 319 ISLHIFMAEVQVS--------PAGPILENQTVTLVCNTPNEAPSDLRYS-WYKNHVLLED 369 +L + +++ + + P+LE Q++ LVC T + P+ L ++ W + + Sbjct: 356 ENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQP 415 Query: 370 AHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVG 429 + L L G + C Q+ GS+ +S+ V++PP + E + Sbjct: 416 SDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVS-LSLSVHYPPQLLGPSCSWEAEG---- 470 Query: 430 ILHCSVVSE--PLATLVLSHGGHILA--STSGDSDHSPRFSGTSGPNSLRL 476 LHCS S+ P +L G +L S+ G + +P +G +SL L Sbjct: 471 -LHCSCSSQASPAPSLRWWLGEELLEGNSSQGSFEVTPSSAGPWANSSLSL 520 Score = 70.1 bits (170), Expect = 2e-11 Identities = 66/238 (27%), Positives = 99/238 (41%), Gaps = 38/238 (15%) Query: 1145 TSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY---------------LLESHGGQLA 1189 T C V + R + L V YAP++L ++ LE GQ Sbjct: 224 TDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFL 283 Query: 1190 LVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQ 1249 +LC DS+PPA L+ R+L+SS P TL LELRG + D G Y+C A + LG Sbjct: 284 RLLCAADSQPPATLSWVLQDRVLSSSHPWG-PRTLGLELRGVRAGDSGRYTCRAENRLGS 342 Query: 1250 ANTSLELRL----EGVRVILA-------------PEAAVPEGAPITVTCADPAAHAPTLY 1292 +L+L + E +RV+++ V EG + + C ++ P Sbjct: 343 QQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSS-PPARL 401 Query: 1293 TWYHNGRWL---QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQ 1347 +W G+ + Q L H G ++C AQ G++ +L V Y PQ Sbjct: 402 SWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHV-SLSLSVHYPPQ 458 Score = 68.6 bits (166), Expect = 5e-11 Identities = 111/480 (23%), Positives = 181/480 (37%), Gaps = 81/480 (16%) Query: 843 QVPSHGRFQAKAEAN--SLKLEVRELGLGDSGSY--RCEATNVLGSSNTSLFFQVRGAWV 898 ++ + RFQ + S L +R+ D Y R E + + S S F ++ + Sbjct: 96 EMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTAL 155 Query: 899 QVSPS---PE-LQEGQAVVLSCQVHTGVPE--GTSYRWYRDGQPLQESTSATLRFAAITL 952 P PE L+ GQ V + C + + S+ W + + +T F+ ++ Sbjct: 156 TKKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSF 215 Query: 953 TQAGAYH-----CQAQAPGSATTSLAAPISLHVSYAPRHVTLTT---------------L 992 T + H C S + L V+YAP+ + ++ Sbjct: 216 TPSPQDHDTDLTCHVDFSRKGV-SAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIY 274 Query: 993 MDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRL 1052 ++ G+ LLC DS PPA L + DR+++S+ P G P TL L Sbjct: 275 LEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSS-----HPWG----------PRTLGL 319 Query: 1053 EIHGAMLEDEGVYICEASNTLGQASASADFDAQ-----------------AVNVQVWPGA 1095 E+ G D G Y C A N LG + D Q N+ Sbjct: 320 ELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSL 379 Query: 1096 TVREGQLVNLTCLVWTTHPAQLTYT-WYQ--DGQQRLDAHSIPLPNVTVRDATSYRCGVG 1152 V EGQ + L C+ ++ PA+L++T W Q Q D + LP + + + C Sbjct: 380 PVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQ 439 Query: 1153 PPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLL 1212 P + +S ++L V Y P+ L + E+ G + C+ + P L LL Sbjct: 440 HPLGSQHVS--LSLSVHYPPQLLGPSCSWEAEGLHCS---CSSQASPAPSLRWWLGEELL 494 Query: 1213 -ASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAV 1271 +S+ S T P G ++ S+ S G ++ L LR + V A +V Sbjct: 495 EGNSSQGSFEVT---------PSSAGPWANSSLSLHGGLSSGLRLRCKAWNVHGAQSGSV 545 Score = 67.0 bits (162), Expect = 1e-10 Identities = 106/409 (25%), Positives = 153/409 (37%), Gaps = 75/409 (18%) Query: 1226 LELRGPQPRDEG--FYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE----GAPITV 1279 L +R Q DE F+ S + + S L+ + P+ +PE G P+TV Sbjct: 116 LVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTV 175 Query: 1280 TC----ADPAAHAPTLYTWYHNGRWL---QEGPAAS----LSFLVATRAHAGAYSCQAQ- 1327 C A AP+ ++W G L + P+ S LSF + + H +C Sbjct: 176 ICVFNWAFKKCPAPS-FSW--TGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDF 232 Query: 1328 DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR---------------SMAVIQCTVDSE 1372 +G + R L+V YAP+D ++S D+ + + C DS+ Sbjct: 233 SRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQ 292 Query: 1373 PPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLL 1431 PPA L+ +VL++S H T L L+++ V AGD Y C A+N L Sbjct: 293 PPATLSWVLQDRVLSSS---HPWGPRT---------LGLELRGVRAGDSGRYTCRAENRL 340 Query: 1432 GSISTIGRLQV----EGARVVAE-------------PGLDVPEGAALNLSCRLLGGPGPV 1474 GS L V E RV+ L V EG +L L C P P Sbjct: 341 GSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSP-PA 399 Query: 1475 GNSTFAWFWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPK 1534 S W L + G + C A+ P G + + L V YPP+ Sbjct: 400 RLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLG-SQHVSLSLSVHYPPQ 458 Query: 1535 TPTMMVFVEPEGGLRGILDCRVDSE--PLASLTLHLGSRLVASSQPQGA 1581 E EG L C S+ P SL LG L+ + QG+ Sbjct: 459 LLGPSCSWEAEG-----LHCSCSSQASPAPSLRWWLGEELLEGNSSQGS 502 Score = 65.5 bits (158), Expect = 4e-10 Identities = 126/517 (24%), Positives = 181/517 (35%), Gaps = 109/517 (21%) Query: 464 RFSGTSGPNSLRLEIRDLEETDSGEY--KCSATNSLGNATSTLDFHANAARLLISPAAEV 521 + +G G S L IRD + D Y + + + ++ + F L P + Sbjct: 104 QLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYI 163 Query: 522 VE----GQAVTLSC--RSGLSPTPDARFSWYLNGALL----------HEGPGSSLLLPAA 565 E GQ VT+ C P FSW GA L H S P Sbjct: 164 PETLEPGQPVTVICVFNWAFKKCPAPSFSW--TGAALSPRRTRPSTSHFSVLSFTPSPQD 221 Query: 566 SSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAA----------GAG 615 TD + +R G SA L V Y P+ + D +A Sbjct: 222 HDTDLTCHVDFSRKGVSAQ---RTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQ 278 Query: 616 AGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVE 675 G+ LLC DS PPA L + +DRV+++S P G P L +E Sbjct: 279 KGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWG------------------PRTLGLE 320 Query: 676 IHNPLLEEEGLYLCEASNALGNASTSATFNGQ--------------ATVLAIAPSHT--- 718 + + G Y C A N LG+ + + Q TVL + T Sbjct: 321 LRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLP 380 Query: 719 LQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQ--GPLE-----TVTLLPVARTDAAL 771 + EG L C + PA SW R W Q GP + + L P+ Sbjct: 381 VLEGQSLRLVCVTH---SSPPARLSWTR----WGQTVGPSQPSDPGVLELPPIQMEHEGE 433 Query: 772 YACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFH 831 + C G+Q + LSV YPP S + H + C+ + P L + Sbjct: 434 FTCHAQHPLGSQ-HVSLSLSVHYPPQLLGPSCSWEAEGLHCS---CSSQASPAPSLRWWL 489 Query: 832 GEHLLATSLGPQVPSHGRFQAKAEA------NSLKLEVRELGLGDSGSYRCEATNVLGSS 885 GE LL + S G F+ + +SL L GL RC+A NV G+ Sbjct: 490 GEELLEGN-----SSQGSFEVTPSSAGPWANSSLSLHG---GLSSGLRLRCKAWNVHGAQ 541 Query: 886 NTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGV 922 + S+F + G +L+ G + L + GV Sbjct: 542 SGSVFQLLPG---------KLEHGGGLGLGAALGAGV 569 Score = 61.6 bits (148), Expect = 6e-09 Identities = 60/200 (30%), Positives = 82/200 (41%), Gaps = 35/200 (17%) Query: 420 FLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIR 479 +LE Q G L C+ S+P ATL +L+S S GP +L LE+R Sbjct: 274 YLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSS-----------SHPWGPRTLGLELR 322 Query: 480 DLEETDSGEYKCSATNSLGNATSTLD----FHANAARLLISPA-------------AEVV 522 + DSG Y C A N LG+ LD + R+++S A V+ Sbjct: 323 GVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVL 382 Query: 523 EGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSS---LLLPAASSTDAGSYHCRARD 579 EGQ++ L C + S P AR SW G + S L LP G + C A+ Sbjct: 383 EGQSLRLVCVTHSS--PPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQ- 439 Query: 580 GHSASGPSSPAVLTVLYPPR 599 H L+V YPP+ Sbjct: 440 -HPLGSQHVSLSLSVHYPPQ 458 Score = 50.1 bits (118), Expect = 2e-05 Identities = 36/119 (30%), Positives = 53/119 (44%), Gaps = 27/119 (22%) Query: 1518 GAAASAPVMLRVLYPPKTPTM---------------MVFVEPEGGLRGILDCRVDSEPLA 1562 G +A V LRV Y PK + ++++E + G L C DS+P A Sbjct: 236 GVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPA 295 Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621 +L+ L R+++SS P G P L +++ +R D G Y C A N LGS Sbjct: 296 TLSWVLQDRVLSSSHPWG------------PRTLGLELRGVRAGDSGRYTCRAENRLGS 342 Score = 38.1 bits (87), Expect = 0.074 Identities = 50/198 (25%), Positives = 71/198 (35%), Gaps = 39/198 (19%) Query: 1453 LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP-----VPTLAFTHVARAQAG 1507 L+V +G L L C P +T +W DR L + L V +G Sbjct: 275 LEVQKGQFLRLLCAADSQPP----ATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSG 330 Query: 1508 MYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI---------------L 1552 Y C AE G+ A + L V YPP+ +MV L + L Sbjct: 331 RYTCRAENRLGSQQQA-LDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRL 389 Query: 1553 DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612 C S P A L+ + V SQP + P L ++ ++ +GE+ Sbjct: 390 VCVTHSSPPARLSWTRWGQTVGPSQP------------SDPGVL--ELPPIQMEHEGEFT 435 Query: 1613 CSASNVLGSASTSTYFGV 1630 C A + LGS S V Sbjct: 436 CHAQHPLGSQHVSLSLSV 453 >gi|31377639 sialic acid binding Ig-like lectin 10 [Homo sapiens] Length = 697 Score = 108 bits (269), Expect = 6e-23 Identities = 131/524 (25%), Positives = 215/524 (41%), Gaps = 74/524 (14%) Query: 8 LLLASFFPAGQASWG---VSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYS 64 LLL+S QA G + + V +G C+ +PC FS+P G T + Y + Sbjct: 5 LLLSSLLGGSQAMDGRFWIRVQESVMVPEGLCISVPCSFSYPRQDWT--GSTPAYGYWFK 62 Query: 65 GQRQV-----VSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEI 119 + V+ + + VE RGR + G+P C+L+++D Q +D Y FR E Sbjct: 63 AVTETTKGAPVATNHQSREVEMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFRVER 122 Query: 120 SEVNRWSDVK-GTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQ-EQVRLQWQG 177 R++ + G + VT + P + P L G V C + + W G Sbjct: 123 GSYVRYNFMNDGFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSWTG 182 Query: 178 QDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANH--RAQSEIHLQVK 235 +SQ +PT H L QDH L C + + AQ + L+V Sbjct: 183 ------AALSSQGTKPT-TSHFSVLSFTPRPQDHNTDLTCHVDFSRKGVSAQRTVRLRVA 235 Query: 236 YAPKGVKILLS--------PSGRNILP------GELVTLTCQVNSSYPAVSSIKWLKDGV 281 YAP+ + I +S P + +P G+ + L C +S PA ++ W+ Sbjct: 236 YAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQPPA--TLSWVLQNR 293 Query: 282 RLQT------KTGVLHLPQAAWSDAGVYTCQAENGVG--------SLVSPPISLHIFMAE 327 L + + L LP D+G YTC+AEN +G S+ PP +L + +++ Sbjct: 294 VLSSSHPWGPRPLGLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQ 353 Query: 328 VQVS--------PAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLL---EDAHSHTLR 376 + + P+LE Q++ LVC T + P+ R SW + +L + + L Sbjct: 354 ANRTVLENLGNGTSLPVLEGQSLCLVCVTHSSPPA--RLSWTQRGQVLSPSQPSDPGVLE 411 Query: 377 LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVV 436 L G + C ++ GS+ +S+ V++ P + E + LHCS Sbjct: 412 LPRVQVEHEGEFTCHARHPLGSQHVS-LSLSVHYSPKLLGPSCSWEAEG-----LHCSCS 465 Query: 437 SE--PLATLVLSHGGHILASTSGDS--DHSPRFSGTSGPNSLRL 476 S+ P +L G +L S + +P +G +SL L Sbjct: 466 SQASPAPSLRWWLGEELLEGNSSQDSFEVTPSSAGPWANSSLSL 509 Score = 80.5 bits (197), Expect = 1e-14 Identities = 77/265 (29%), Positives = 116/265 (43%), Gaps = 33/265 (12%) Query: 1093 PGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH-------SIPLPNVTVRDAT 1145 P ++GQ + L C + PA T +W + +H + LP V D+ Sbjct: 262 PYLEAQKGQFLRLLCAADSQPPA--TLSWVLQNRVLSSSHPWGPRPLGLELPGVKAGDSG 319 Query: 1146 SYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY------LLESHG---------GQLAL 1190 Y C R R + L V Y P NLR+ +LE+ G GQ Sbjct: 320 RYTCRA--ENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLC 377 Query: 1191 VLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQA 1250 ++C S PPA+L+ + G++L+ S + P L EL Q EG ++C AR PLG Sbjct: 378 LVCVTHSSPPARLSWTQRGQVLSPSQPSD-PGVL--ELPRVQVEHEGEFTCHARHPLGSQ 434 Query: 1251 NTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLS 1310 + SL L + +L P + E + +C+ A+ AP+L W G L EG ++ S Sbjct: 435 HVSLSLSVHYSPKLLGPSCSW-EAEGLHCSCSSQASPAPSLRWWL--GEELLEGNSSQDS 491 Query: 1311 FLVATRAHAGAYSCQAQDAQGTRSS 1335 F V T + AG ++ + G SS Sbjct: 492 FEV-TPSSAGPWANSSLSLHGGLSS 515 Score = 73.2 bits (178), Expect = 2e-12 Identities = 111/475 (23%), Positives = 176/475 (37%), Gaps = 85/475 (17%) Query: 843 QVPSHGRFQAKAEA--NSLKLEVRELGLGDSGSY--RCEATNVLGSSNTSLFFQVRGAWV 898 ++ + GRFQ + + L +R+ + D Y R E + + + + F ++ + Sbjct: 83 EMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFRVERGSYVRYNFMNDGFFLKVTAL 142 Query: 899 QVSPS---PE-LQEGQAVVLSCQVHTGVPE--GTSYRWYRDGQPLQESTSATLRFAAITL 952 P PE L+ GQ V + C + E S+ W Q + T F+ ++ Sbjct: 143 TQKPDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSWTGAALSSQGTKPTTSHFSVLSF 202 Query: 953 TQAGAYH-----CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP---------- 997 T H C S + L V+YAPR + ++ D P Sbjct: 203 TPRPQDHNTDLTCHVDFSRKGV-SAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNV 261 Query: 998 -------GRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTL 1050 G+ LLC DS PPA L + +R+++S+ P G P L Sbjct: 262 PYLEAQKGQFLRLLCAADSQPPATLSWVLQNRVLSSS-----HPWG----------PRPL 306 Query: 1051 RLEIHGAMLEDEGVYICEASNTLGQASASADFDAQ-----------------AVNVQVWP 1093 LE+ G D G Y C A N LG + D Q N+ Sbjct: 307 GLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGT 366 Query: 1094 GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQ-----QRLDAHSIPLPNVTVRDATSYR 1148 V EGQ + L C+ ++ PA+L +W Q GQ Q D + LP V V + Sbjct: 367 SLPVLEGQSLCLVCVTHSSPPARL--SWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFT 424 Query: 1149 CGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHA 1208 C P + +S ++L V Y+P+ L + E+ G + C+ + P L Sbjct: 425 CHARHPLGSQHVS--LSLSVHYSPKLLGPSCSWEAEGLHCS---CSSQASPAPSLRWWLG 479 Query: 1209 GRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRV 1263 LL +++ P G ++ S+ S G ++ L LR E V Sbjct: 480 EELLEGNSSQDSFEV--------TPSSAGPWANSSLSLHGGLSSGLRLRCEAWNV 526 Score = 68.6 bits (166), Expect = 5e-11 Identities = 64/240 (26%), Positives = 100/240 (41%), Gaps = 40/240 (16%) Query: 1145 TSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY-----------------LLESHGGQ 1187 T C V + R + L V YAPR+L ++ LE+ GQ Sbjct: 211 TDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQ 270 Query: 1188 LALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPL 1247 +LC DS+PPA L+ R+L+SS P L LEL G + D G Y+C A + L Sbjct: 271 FLRLLCAADSQPPATLSWVLQNRVLSSSHPWG-PRPLGLELPGVKAGDSGRYTCRAENRL 329 Query: 1248 GQANTSLELRL----EGVRVILA-------------PEAAVPEGAPITVTCADPAAHAPT 1290 G +L+L + E +RV+++ V EG + + C ++ P Sbjct: 330 GSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLCLVCVTHSS-PPA 388 Query: 1291 LYTWYHNGRWLQEGPAASLSFLVATRA---HAGAYSCQAQDAQGTRSSRPAALQVLYAPQ 1347 +W G+ L + L R H G ++C A+ G++ +L V Y+P+ Sbjct: 389 RLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCHARHPLGSQHV-SLSLSVHYSPK 447 Score = 61.2 bits (147), Expect = 8e-09 Identities = 60/200 (30%), Positives = 81/200 (40%), Gaps = 35/200 (17%) Query: 420 FLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIR 479 +LE Q G L C+ S+P ATL +L+S S GP L LE+ Sbjct: 263 YLEAQKGQFLRLLCAADSQPPATLSWVLQNRVLSS-----------SHPWGPRPLGLELP 311 Query: 480 DLEETDSGEYKCSATNSLGNATSTLD----FHANAARLLISPA-------------AEVV 522 ++ DSG Y C A N LG+ LD + R+++S A V+ Sbjct: 312 GVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVL 371 Query: 523 EGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSS---LLLPAASSTDAGSYHCRARD 579 EGQ++ L C + S P AR SW G +L S L LP G + C AR Sbjct: 372 EGQSLCLVCVTHSS--PPARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCHAR- 428 Query: 580 GHSASGPSSPAVLTVLYPPR 599 H L+V Y P+ Sbjct: 429 -HPLGSQHVSLSLSVHYSPK 447 Score = 57.4 bits (137), Expect = 1e-07 Identities = 96/366 (26%), Positives = 131/366 (35%), Gaps = 75/366 (20%) Query: 1267 PEAAVPE----GAPITVTCADPAAHA---PTLYTWYHNGRWLQ-EGPAAS----LSFLVA 1314 P+ +PE G P+TV C A P ++W Q P S LSF Sbjct: 146 PDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSWTGAALSSQGTKPTTSHFSVLSFTPR 205 Query: 1315 TRAHAGAYSCQAQ-DAQGTRSSRPAALQVLYAPQDAVLSSFRD----------------- 1356 + H +C +G + R L+V YAP+D V+S RD Sbjct: 206 PQDHNTDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLE 265 Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416 ++ + C DS+PPA L+ +VL++S H R L L++ V Sbjct: 266 AQKGQFLRLLCAADSQPPATLSWVLQNRVLSSS-----------HPWGPR-PLGLELPGV 313 Query: 1417 PAGDD-TYVCTAQNLLGSISTIGRLQV----EGARVVAE-------------PGLDVPEG 1458 AGD Y C A+N LGS L V E RV+ L V EG Sbjct: 314 KAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEG 373 Query: 1459 AALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQA---GMYHCLAEL 1515 +L L C P + +W + L + R Q G + C A Sbjct: 374 QSLCLVCVTHSSP----PARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCHARH 429 Query: 1516 PTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSE--PLASLTLHLGSRLV 1573 P G + + L V Y PK E EG L C S+ P SL LG L+ Sbjct: 430 PLG-SQHVSLSLSVHYSPKLLGPSCSWEAEG-----LHCSCSSQASPAPSLRWWLGEELL 483 Query: 1574 ASSQPQ 1579 + Q Sbjct: 484 EGNSSQ 489 Score = 53.9 bits (128), Expect = 1e-06 Identities = 117/475 (24%), Positives = 163/475 (34%), Gaps = 80/475 (16%) Query: 464 RFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD--FHANAARLLISPAAEV 521 + +G + L IRD + D +Y + ++ F L P + Sbjct: 91 QLTGDPAKGNCSLVIRDAQMQDESQYFFRVERGSYVRYNFMNDGFFLKVTALTQKPDVYI 150 Query: 522 VE----GQAVTLSC--RSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHC 575 E GQ VT+ C P FSW GA L S P S S+ Sbjct: 151 PETLEPGQPVTVICVFNWAFEECPPPSFSW--TGAAL----SSQGTKPTTSHFSVLSFTP 204 Query: 576 RARDGH---------SASGPSSPAV--LTVLYPPRQPTFTTRLDLDAA------------ 612 R +D + S G S+ L V Y PR + D A Sbjct: 205 RPQDHNTDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYL 264 Query: 613 GAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLL 672 A G+ LLC DS PPA L + ++RV+++S P G P L Sbjct: 265 EAQKGQFLRLLCAADSQPPATLSWVLQNRVLSSSHPWG------------------PRPL 306 Query: 673 RVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQ--------------ATVLAIAPSHT 718 +E+ + G Y C A N LG+ + + Q TVL + T Sbjct: 307 GLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGT 366 Query: 719 LQEGTEANLTCNVSREAAGSPANFSWFRNG-VLWAQGPLETVTL-LPVARTD-AALYACR 775 E C V + PA SW + G VL P + L LP + + + C Sbjct: 367 SLPVLEGQSLCLVCVTHSSPPARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCH 426 Query: 776 ILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHL 835 G+Q + LSV Y P S + H + C+ + P L + GE L Sbjct: 427 ARHPLGSQ-HVSLSLSVHYSPKLLGPSCSWEAEGLHCS---CSSQASPAPSLRWWLGEEL 482 Query: 836 LATSLGPQVPSHGRFQAKAEAN-SLKLEVRELGLGDSGSYRCEATNVLGSSNTSL 889 L + A AN SL L GL RCEA NV G+ + S+ Sbjct: 483 LEGNSSQDSFEVTPSSAGPWANSSLSLHG---GLSSGLRLRCEAWNVHGAQSGSI 534 Score = 47.8 bits (112), Expect = 9e-05 Identities = 36/121 (29%), Positives = 55/121 (45%), Gaps = 29/121 (23%) Query: 1518 GAAASAPVMLRVLYPPK----------TPTM-------MVFVEPEGGLRGILDCRVDSEP 1560 G +A V LRV Y P+ TP + + ++E + G L C DS+P Sbjct: 223 GVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQP 282 Query: 1561 LASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620 A+L+ L +R+++SS P G P L +++ ++ D G Y C A N LG Sbjct: 283 PATLSWVLQNRVLSSSHPWG------------PRPLGLELPGVKAGDSGRYTCRAENRLG 330 Query: 1621 S 1621 S Sbjct: 331 S 331 Score = 37.7 bits (86), Expect = 0.096 Identities = 53/200 (26%), Positives = 77/200 (38%), Gaps = 39/200 (19%) Query: 1451 PGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAE----PVPT-LAFTHVARAQ 1505 P L+ +G L L C P +T +W +R L + P P L V Sbjct: 262 PYLEAQKGQFLRLLCAADSQPP----ATLSWVLQNRVLSSSHPWGPRPLGLELPGVKAGD 317 Query: 1506 AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI-------------- 1551 +G Y C AE G+ A + L V YPP+ +MV L + Sbjct: 318 SGRYTCRAENRLGSQQRA-LDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSL 376 Query: 1552 -LDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGE 1610 L C S P A L+ ++++ SQP ++P + L RV +E +GE Sbjct: 377 CLVCVTHSSPPARLSWTQRGQVLSPSQP----SDPGVLELP-----RVQVE-----HEGE 422 Query: 1611 YICSASNVLGSASTSTYFGV 1630 + C A + LGS S V Sbjct: 423 FTCHARHPLGSQHVSLSLSV 442 >gi|144226847 obscurin-like 1 [Homo sapiens] Length = 1896 Score = 106 bits (265), Expect = 2e-22 Identities = 323/1368 (23%), Positives = 470/1368 (34%), Gaps = 256/1368 (18%) Query: 190 KFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSG 249 + E G+ H LH A+ QD G ++ + Q L ++ +P + LSP Sbjct: 671 RIEQKGLQHRLILH-AVKHQDSGALV----GFSCPGVQDSAALTIQESPVHI---LSPQD 722 Query: 250 RNILP---GELVTLTCQVNS-SYPAVSSIKWLKDG----------VRLQTKTGVLHLPQA 295 R L E V LTC+++ +PA W KDG V++ + L LP+A Sbjct: 723 RVSLTFTTSERVVLTCELSRVDFPAT----WYKDGQKVEESELLVVKMDGRKHRLILPEA 778 Query: 296 AWSDAGVYTCQAEN-----GVGSLVSPPISL-----HIFMAEVQVSPAGPILENQTVTLV 345 D+G + C+ E GV ++ PP+ + H+F+ + ++ V L Sbjct: 779 KVQDSGEFECRTEGVSAFFGV-TVQDPPVHIVDPREHVFVHAI---------TSECVMLA 828 Query: 346 CNTPNEAPSDLRYSWYK--------NHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHG 397 C E D WYK + V+LE+ H + AT+ G E Q V G Sbjct: 829 CEVDRE---DAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDG---GEFQCVAG 882 Query: 398 SERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSG 457 E + + + +++++ +G V + + L + + + G Sbjct: 883 DECAYFTVTITD-------VSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDG 935 Query: 458 DS-DHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLIS 516 + SP RL + ++ DSGEY C + + T T+ +I Sbjct: 936 EEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTV---TEPPVRIIY 992 Query: 517 PAAEVVEGQAVTLSCRSGLS--PTPDARFSWYLNG---------ALLHEGPGSSLLLPAA 565 P EV AVTL C + DA WY +G L +GP L+LPAA Sbjct: 993 PRDEVTL-IAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAA 1051 Query: 566 SSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCR 625 D G + C A D S+ +TV PP + LD GR L R Sbjct: 1052 QPEDGGEFVCDAGD------DSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVEL---R 1102 Query: 626 VDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685 + P +KD + G P +T + + E+ G Sbjct: 1103 CEVAPAGSQVRWYKDGLEV----EASDALQLGAEGPTRTLT---------LPHAQPEDAG 1149 Query: 686 LYLCEASNALGNASTSATFN-------GQATVLAIAPSH-TLQEGTEANLTCNVSREAAG 737 Y+CE + + TFN Q L PS + G L+C +SR AG Sbjct: 1150 EYVCETRH------EAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSR--AG 1201 Query: 738 SPANFSWFRNG---------VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPV 788 +P W NG L A+GP + + A LY C ++GA P Sbjct: 1202 APV--VWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTC----QSGAAPGAPS 1255 Query: 789 LLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALF-----HGEHLLATSLGPQ 843 L + + P + Q V S P L L G + G + Sbjct: 1256 LSFTVQVAEPPVRVVAPEAAQ-------TRVRSTPGGDLELVVHLSGPGGPVRWYKDGER 1308 Query: 844 VPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPS 903 + S GR Q + L V+ GD+G Y C+A S+ + V Sbjct: 1309 LASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTP 1368 Query: 904 PELQEGQAVVLSCQVHTGVPEGTSYRWYRDG---------QPLQESTSATLRFAAITLTQ 954 + EG C+V P W R+G + Q +S L L Sbjct: 1369 LTVHEGDDATFRCEVS---PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGD 1425 Query: 955 AGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQ 1014 AG +A GS TS LHV + L L D R + Sbjct: 1426 AGTVTLRA---GSTATS----ARLHVR-ETELLFLRRLQDV----------RAEEGQDVC 1467 Query: 1015 LRLLHGDRLVASTLQGV--GGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA--S 1070 L + G A ++ V G P RL +A + RL IHG +L D+G Y CE+ Sbjct: 1468 LEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHD 1527 Query: 1071 NTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLD 1130 TL + S Q ++ T+ EG +T W + G Q Sbjct: 1528 RTLARLSVR---PRQLRVLRPLEDVTISEGGSATFQL---ELSQEGVTGEWARGGVQLYP 1581 Query: 1131 A-----------HSIPLPNVTVRD-------ATSYRCGVGPPGRAPRLSRPITLDVLYAP 1172 H + L + + D A S RC A + R + + ++ P Sbjct: 1582 GPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCA------ARLIVREVPVTIVRGP 1635 Query: 1173 RNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVP--NTLR-LELR 1229 +L +T G A C + S+ A + G L S + T R L+LR Sbjct: 1636 HDLEVT------EGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLR 1688 Query: 1230 GPQPRDEGFYSCS-ARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHA 1288 P D G YSC+ + G ++ R V L +A EG T C + Sbjct: 1689 RCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSA-REGDGATFECT--VSEV 1745 Query: 1289 PTLYTWYHNGRWL---------QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAA 1339 T W GR L QEG L AG QA AQ A Sbjct: 1746 ETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSL-----AL 1800 Query: 1340 LQVLYAPQDAVLSSFRDSR--ARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLAS 1397 L+V P R+ AV++ TV S + +G L + Sbjct: 1801 LEVEALPLQMCRHPPREKTVLVGRRAVLEVTV-SRSGGHVCWLREGAELCPGDKYEMRSH 1859 Query: 1398 GTGHVQVARNALRLQVQDV-PAGDDTYVCTAQNLLGSISTIGRLQVEG 1444 G H L + DV P TY C A G ST RL VEG Sbjct: 1860 GPTH--------SLVIHDVRPEDQGTYCCQA----GQDSTHTRLLVEG 1895 Score = 89.7 bits (221), Expect = 2e-17 Identities = 290/1335 (21%), Positives = 442/1335 (33%), Gaps = 273/1335 (20%) Query: 244 LLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRL--------------QTKTG- 288 L P + +L G V LTC+ ++ W KDG+ L + + G Sbjct: 131 LTGPRSQWVLRGAEVVLTCRAGGL--PEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP 188 Query: 289 ----VLHLPQAAWSDAGVYTCQAENGVG--------SLVSPPISLHIFMAEVQVSPAGPI 336 L + A D+GVY C A N G + PP S E P+ Sbjct: 189 GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248 Query: 337 L---------ENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH---------SHTLRLH 378 E + C + ++ + W + LL D L++ Sbjct: 249 KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHW-EGRPLLPDRRRLMYRDRDGGFVLKVL 307 Query: 379 LATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGL---VGILHCSV 435 D G Y C +N G S V + V P L T L+ G + +L C V Sbjct: 308 YCQAKDRGLYVCAARNSAGQTLSA-VQLHVKEPRLR--FTRPLQDVEGREHGIAVLECKV 364 Query: 436 VSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSA-- 493 + + T +L ++ RL I L+ D G Y C Sbjct: 365 PNSRIPTAWFREDQRLLPCR--------KYEQIEEGTVRRLIIHRLKADDDGIYLCEMRG 416 Query: 494 -TNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALL 552 ++ N T R L +V+EG+ L + L + R W +G L Sbjct: 417 RVRTVANVTVKGPILKRLPRKL-----DVLEGENAVLLVET-LEAGVEGR--WSRDGEEL 468 Query: 553 ------HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTR 606 G +L+LP + DAG G+S + PP P Sbjct: 469 PVICQSSSGHMHALVLPGVTREDAGEVTFSL--GNSRTTTLLRVKCVKHSPPGPPILAEM 526 Query: 607 LDLDAAGAGAGRRGLLLCRVDSDPPA----------RLQLLHKDRVVATSLPSGGGCSTC 656 G + +L PA R ++ +D + S+ G Sbjct: 527 FK--------GHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVP 578 Query: 657 GGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNA-STSATFNGQA----TVL 711 G C P EG Y G+ S F+G A T Sbjct: 579 GDCVP---------------------SEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTAR 617 Query: 712 AIAPSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRNGV-------------------L 750 +A +Q +G +A + ++S G+ WF NG + Sbjct: 618 LVAGLEDVQVYDGEDAVFSLDLSTIIQGT-----WFLNGEELKSNEPEGQVEPGALRYRI 672 Query: 751 WAQGPLETVTLLPVARTDAAL---YACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDM 807 +G + L V D+ ++C + ++ A + +L P DR L+ Sbjct: 673 EQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTS- 731 Query: 808 GQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELG 867 + T + + A ++ + G +V K + +L + E Sbjct: 732 -----ERVVLTCELSRVDFPATWYKD-------GQKVEESELLVVKMDGRKHRLILPEAK 779 Query: 868 LGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE----------GQAVVLSCQ 917 + DSG + C V S FF G VQ P + + V+L+C+ Sbjct: 780 VQDSGEFECRTEGV------SAFF---GVTVQDPPVHIVDPREHVFVHAITSECVMLACE 830 Query: 918 VHTGVPEGTSYRWYRDGQPLQESTSATL------RFAAITLTQ---AGAYHCQAQAPGSA 968 V E RWY+DGQ ++ES L R + TQ G + C A + Sbjct: 831 VDR---EDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAY 887 Query: 969 TTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLH-GDRLVAST 1027 T +S + Y P + L LCR P A++R G+ +V Sbjct: 888 FTVTITDVSSWIVY-PSGKVYVAAVRLERVVLTCELCR----PWAEVRWTKDGEEVV--- 939 Query: 1028 LQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAV 1087 SP L + RL + LED G Y+CE + AS + V Sbjct: 940 ---------ESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDE--SASFTVTVTEPPV 988 Query: 1088 NVQVWPGATVREGQLVNLTCLVWTTHPAQ--LTYTWYQDGQQRLDAHSIPL--------- 1136 + ++P V V L C+V ++ WY+DG + ++ ++ L Sbjct: 989 RI-IYPRDEVTL-IAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRL 1046 Query: 1137 --PNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNL--RLTYLLESHGGQLALVL 1192 P D + C G S T+ V P + L+ H G V Sbjct: 1047 VLPAAQPEDGGEFVCDAGDD------SAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVE 1100 Query: 1193 CTVDSRPP-AQLALSHAGRLLASSTAASVPN---TLRLELRGPQPRDEGFYSCSARSPLG 1248 + P +Q+ G + +S A + T L L QP D G Y C R Sbjct: 1101 LRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAI 1160 Query: 1249 QANTSLE---LRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEG- 1304 N L ++ + +P P G P+ ++C A AP + W HNGR +QEG Sbjct: 1161 TFNVILAEPPVQFLALETTPSPLCVAP-GEPVVLSCELSRAGAPVV--WSHNGRPVQEGE 1217 Query: 1305 --------PAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRD 1356 P L A AHAG Y+CQ+ A G S +QV P V Sbjct: 1218 GLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGA-PSLSFTVQVAEPPVRVVAPEAAQ 1276 Query: 1357 SRARSM--AVIQCTVD-SEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQV 1413 +R RS ++ V S P + DG+ LA+ V +G V L+V Sbjct: 1277 TRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQV--------LRV 1328 Query: 1414 QDVPAGD-DTYVCTA 1427 Q +GD Y+C A Sbjct: 1329 QGARSGDAGEYLCDA 1343 Score = 89.7 bits (221), Expect = 2e-17 Identities = 267/1242 (21%), Positives = 418/1242 (33%), Gaps = 214/1242 (17%) Query: 475 RLEIRDLEETDSGEYKC---SATNSLGNATSTLDFHANAARLLISPAAEV----VEGQAV 527 RL + + + DSGE++C + G H ++ P V + + V Sbjct: 772 RLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVH------IVDPREHVFVHAITSECV 825 Query: 528 TLSCRSGLSPTPDARFSWYLNG---------ALLHEGPGSSLLLPAASSTDAGSYHCRAR 578 L+C DA WY +G L +EGP L+LPA +D G + C A Sbjct: 826 MLACEVDRE---DAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAG 882 Query: 579 DGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLH 638 D + + V + + P + + L+ R +L C + P A ++ Sbjct: 883 DECAYFTVTITDVSSWIVYPSGKVYVAAVRLE--------RVVLTCEL-CRPWAEVRWTK 933 Query: 639 KDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNA 698 V S P + + K + R+ + LE+ G YLCE + + Sbjct: 934 DGEEVVES--------------PALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASF 979 Query: 699 STSATF--------NGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFRNG-- 748 + + T + T++A+ + L C +SRE A W+++G Sbjct: 980 TVTVTEPPVRIIYPRDEVTLIAVTLECVV-------LMCELSRE----DAPVRWYKDGLE 1028 Query: 749 -------VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDR--P 799 VL GP + L D + C +AG S ++V PP+R Sbjct: 1029 VEESEALVLERDGPRCRLVLPAAQPEDGGEFVC----DAGDD-SAFFTVTVTAPPERIVH 1083 Query: 800 KLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSL 859 + LD+ G + P ++ + G +V + Q AE + Sbjct: 1084 PAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKD-------GLEVEASDALQLGAEGPTR 1136 Query: 860 KLEVRELGLGDSGSYRCEATNVLGSSNTSLFF-QVRGAWVQVSPSPE-LQEGQAVVLSCQ 917 L + D+G Y CE + + N L V+ ++ +PSP + G+ VVLSC+ Sbjct: 1137 TLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCE 1196 Query: 918 VHTGVPEGTSYRWYRDGQPLQESTSATLR---------FAAITLTQAGAYHCQA-QAPGS 967 + G W +G+P+QE L A AG Y CQ+ APG+ Sbjct: 1197 LSRA---GAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGA 1253 Query: 968 ATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVAST 1027 + S ++ V+ P V T RV S P L L+ Sbjct: 1254 PSLS----FTVQVAEPPVRVVAPEAAQT----------RVRSTPGGDLELV-------VH 1292 Query: 1028 LQGVGGPE---------GSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASA 1078 L G GGP S R+ + A L + GA D G Y+C+A Sbjct: 1293 LSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLV 1352 Query: 1079 SADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPL-P 1137 S + V TV EG C V P TW ++G + + Sbjct: 1353 SVEEPLLVKLVSELTPLTVHEGDDATFRCEV---SPPDADVTWLRNGAVVTPGPQVEMAQ 1409 Query: 1138 NVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLE------SHGGQLALV 1191 N + R T C +G G + R L +L G + L Sbjct: 1410 NGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLE 1469 Query: 1192 LCTVDSRPPAQLALSHAGRLLASSTAASVP---NTLRLELRGPQPRDEGFYSCSARSPLG 1248 + T + G+ L + S+ + RL + G D+G Y C + Sbjct: 1470 VETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRT 1529 Query: 1249 QANTSLELRLEGVRVILAPE-AAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAA 1307 A L +R +RV+ E + EG T + W G L GP Sbjct: 1530 LAR--LSVRPRQLRVLRPLEDVTISEGGSATFQL--ELSQEGVTGEWARGGVQLYPGPKC 1585 Query: 1308 SLSF------LVATRAHAGAYSCQAQDAQGTRSS-----RPAALQVLYAPQDAVLSSFRD 1356 + LV C + A R + R + ++ P D ++ Sbjct: 1586 HIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTE--- 1642 Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416 A +C + S+ A++ DG L S + A GT R L+L+ + Sbjct: 1643 ---GDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGT------RRLLQLR-RCG 1691 Query: 1417 PAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNLSCRL--------- 1467 P+ TY C + + A + + EG C + Sbjct: 1692 PSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRW 1751 Query: 1468 -LGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHV--ARAQAGMYHCLAELPTGAAASAP 1524 LGG P+ + + H + L R QAG LA L A P Sbjct: 1752 ELGG-RPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEA---LP 1807 Query: 1525 VMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAE 1584 + + +PP+ T++V G R +L+ V L G+ L + + Sbjct: 1808 LQM-CRHPPREKTVLV------GRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHG 1860 Query: 1585 PHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTST 1626 P H L I +RP DQG Y C A G ST T Sbjct: 1861 P-THSLV--------IHDVRPEDQGTYCCQA----GQDSTHT 1889 Score = 62.0 bits (149), Expect = 5e-09 Identities = 96/410 (23%), Positives = 138/410 (33%), Gaps = 90/410 (21%) Query: 247 PSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAA 296 P ++ G L C V P V + W K G +L + L L A Sbjct: 18 PRPVRVVSGAEAELKCVVLGEPPPV--VVWEKGGQQLAASERLSFPADGAEHGLLLTAAL 75 Query: 297 WSDAGVYTCQAENGVG--------SLVSPPISLHIFMAEVQVSPA------------GP- 335 +DAGVY C+A N G +++ PP S + P+ GP Sbjct: 76 PTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPR 135 Query: 336 ---ILENQTVTLVCNTPNEAPSDLRYS---------WYKNHVLLEDAHSH-------TLR 376 +L V L C L + W +H L+ + LR Sbjct: 136 SQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALR 195 Query: 377 LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVV 436 + A D+G Y C +N HG ++G + + V+ PP +P E A +V L C+ Sbjct: 196 ILAARLPDSGVYVCHARNAHGHAQAGAL-LQVHQPPESPPADPD-EAPAPVVEPLKCAP- 252 Query: 437 SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSG-----PNSLRLEIRD----------- 480 T ++ G H P P+ RL RD Sbjct: 253 ----KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLY 308 Query: 481 LEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQ---AVTLSCRSGLSP 537 + D G Y C+A NS G S + H RL + + VEG+ L C+ S Sbjct: 309 CQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSR 368 Query: 538 TPDARFSWYLNGALL---------HEGPGSSLLLPAASSTDAGSYHCRAR 578 P A W+ L EG L++ + D G Y C R Sbjct: 369 IPTA---WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMR 415 Score = 55.5 bits (132), Expect = 4e-07 Identities = 92/368 (25%), Positives = 129/368 (35%), Gaps = 78/368 (21%) Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLR---LELRGPQPRDEGFYSCS 1242 G A + C V PP + G+ LA+S S P L L P D G Y C Sbjct: 26 GAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCR 85 Query: 1243 ARSPLGQANTSLELRL-----------------------EGVRVILAPEAA--VPEGAPI 1277 AR+ G+A + + + EG V L + V GA + Sbjct: 86 ARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEV 145 Query: 1278 TVTCADPAAHAPTLYTWYHNGRWLQE----------------GPAASLS--FLVATRAHA 1319 +TC PTLY W +G L E GP ASL+ L A + Sbjct: 146 VLTCRAGGLPEPTLY-WEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDS 204 Query: 1320 GAYSCQAQDAQGTRSSRPAALQVLYAPQD----------AVLSSFRDS------RARSMA 1363 G Y C A++A G + A LQV P+ V+ + + A Sbjct: 205 GVYVCHARNAHG-HAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHA 263 Query: 1364 VIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTY 1423 +C V +P E+ +G+ L G + L Q +D Y Sbjct: 264 KFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVL--KVLYCQAKD----RGLY 317 Query: 1424 VCTAQNLLGSISTIGRLQVEGARV-VAEPGLDVP--EGAALNLSCRLLGGPGPVGNSTFA 1480 VC A+N G + +L V+ R+ P DV E L C++ P A Sbjct: 318 VCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKV-----PNSRIPTA 372 Query: 1481 WFWNDRRL 1488 WF D+RL Sbjct: 373 WFREDQRL 380 Score = 52.4 bits (124), Expect = 4e-06 Identities = 108/442 (24%), Positives = 153/442 (34%), Gaps = 94/442 (21%) Query: 554 EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPR-----QPTFTTRLD 608 +G LLL AA TDAG Y CRAR ++A + A +TVL PP QP L Sbjct: 63 DGAEHGLLLTAALPTDAGVYVCRAR--NAAGEAYAAAAVTVLEPPASDPELQPA-ERPLP 119 Query: 609 LDAAGAGA--------------GRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCS 654 +G GA G +L CR P L KD + + + Sbjct: 120 SPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTL-YWEKDGMALDEVWDSSHFA 178 Query: 655 TCGGCSPRMKVTKAPNL-LRVEIHNPLLEEEGLYLCEASNALGNASTSATFN-------- 705 G + P L + I L + G+Y+C A NA G+A A Sbjct: 179 LQPG-----RAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP 233 Query: 706 ----GQATVLAIAP------SHTLQEGTEANLTCNVSREAAGSP-ANFSWFRNGVLWAQG 754 +A + P + + EG A C V G P W W Sbjct: 234 PADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYV----MGKPEPEIEWH-----WEGR 284 Query: 755 PL---------------ETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRP 799 PL + +L D LY C AG LS V L V P R Sbjct: 285 PLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSA-VQLHVKEP--RL 341 Query: 800 KLSALLDMGQGH---MALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEA 856 + + L +G +A+ C V + + + LL +++ E Sbjct: 342 RFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCR---------KYEQIEEG 392 Query: 857 NSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSP-ELQEGQAVVLS 915 +L + L D G Y CE + G T V+G ++ P ++ EG+ VL Sbjct: 393 TVRRLIIHRLKADDDGIYLCE---MRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLL 449 Query: 916 CQVHTGVPEGTSYRWYRDGQPL 937 + + G RW RDG+ L Sbjct: 450 VET---LEAGVEGRWSRDGEEL 468 Score = 49.3 bits (116), Expect = 3e-05 Identities = 146/666 (21%), Positives = 232/666 (34%), Gaps = 127/666 (19%) Query: 898 VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYR---------------WYRDGQPLQESTS 942 VQ S + +QE +LS Q + TS R WY+DGQ ++ES Sbjct: 702 VQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESEL 761 Query: 943 ATLR---------FAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLM 993 ++ + +G + C+ + + +H+ HV + + Sbjct: 762 LVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAI- 820 Query: 994 DTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLE 1053 +L C VD + A +R + V + V EG RL V P T Sbjct: 821 ---TSECVMLACEVDRE-DAPVRWYKDGQEVEESDFVVLENEGPHRRL---VLPAT---- 869 Query: 1054 IHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVW---PG-----ATVREGQLVNL 1105 D G + C A + A F +V W P A VR ++V L Sbjct: 870 ----QPSDGGEFQCVAGD------ECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVV-L 918 Query: 1106 TCLV---WTTHPAQLTYTWYQDGQQRLDA-----------HSIPLPNVTVRDATSYRCGV 1151 TC + W W +DG++ +++ + LP V + D+ Y C + Sbjct: 919 TCELCRPWA------EVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEI 972 Query: 1152 GPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVD--------SRPPAQL 1203 S T+ V P +R+ Y + ++ L+ T++ SR A + Sbjct: 973 DDE------SASFTVTVTEPP--VRIIYPRD----EVTLIAVTLECVVLMCELSREDAPV 1020 Query: 1204 ALSHAGRLLASSTAASVPN---TLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG 1260 G + S A + RL L QP D G + C A ++ E Sbjct: 1021 RWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPER 1080 Query: 1261 VRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQ---------EGPAASLSF 1311 + A + GAP V A A + WY +G ++ EGP +L+ Sbjct: 1081 IVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTL 1140 Query: 1312 LVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDS 1371 A AG Y C+ + T + A V + + S + + V+ C + S Sbjct: 1141 PHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPV-VLSCEL-S 1198 Query: 1372 EPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLL 1431 A + SH+G+ + G+ H + R L +Q PA Y C + Sbjct: 1199 RAGAPVVWSHNGRPVQEGEGLEL------HAEGPRRVLCIQAAG-PAHAGLYTCQSGAAP 1251 Query: 1432 GSISTIGRLQV--EGARVVAEPGLDV----PEGAALNLSCRLLGGPGPVGNSTFAWFWND 1485 G+ S +QV RVVA G L L L G GPV W+ + Sbjct: 1252 GAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPV-----RWYKDG 1306 Query: 1486 RRLHAE 1491 RL ++ Sbjct: 1307 ERLASQ 1312 Score = 37.0 bits (84), Expect = 0.16 Identities = 75/352 (21%), Positives = 116/352 (32%), Gaps = 89/352 (25%) Query: 683 EEGLYLCEASNALGNASTSATFN-------------------------GQATVLAIAPSH 717 + G+Y+C A NA G A +A G L S Sbjct: 78 DAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQ 137 Query: 718 TLQEGTEANLTCNVSREAAGSPA-NFSWFRNGV----LW------------AQGPLETVT 760 + G E LTC A G P W ++G+ +W GP ++ Sbjct: 138 WVLRGAEVVLTCR----AGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLA 193 Query: 761 L--LPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSA--------------- 803 L L D+ +Y C G LL V PP+ P Sbjct: 194 LRILAARLPDSGVYVCHARNAHG-HAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAP 252 Query: 804 -LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLE 862 + +G A F C V +P + +H E P +P R + L+ Sbjct: 253 KTFWVNEGKHAKFRCYVMGKPEPEIE-WHWEGR------PLLPDRRRLMYRDRDGGFVLK 305 Query: 863 VRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQ---AVVLSCQV- 918 V D G Y C A N G + +++ V+ ++ + + EG+ VL C+V Sbjct: 306 VLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVP 365 Query: 919 HTGVPEGTSYRWYRDGQPL---------QESTSATLRFAAITLTQAGAYHCQ 961 ++ +P W+R+ Q L +E T L + G Y C+ Sbjct: 366 NSRIPTA----WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCE 413 Score = 35.0 bits (79), Expect = 0.63 Identities = 31/106 (29%), Positives = 40/106 (37%), Gaps = 17/106 (16%) Query: 1517 TGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASS 1576 +G S P LR P V G L C V EP + G + +A+S Sbjct: 5 SGDQGSPPCFLRFPRP---------VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAAS 55 Query: 1577 QPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622 + PA+ H L AL P+D G Y+C A N G A Sbjct: 56 ERLSFPADGAEHGLLLTAAL--------PTDAGVYVCRARNAAGEA 93 Score = 31.6 bits (70), Expect = 6.9 Identities = 69/292 (23%), Positives = 101/292 (34%), Gaps = 62/292 (21%) Query: 100 LLLKDLQPEDSGSY--NFRFEISEVNRWSDVKGTLVTVTEEP----RVPTIASPVELLEG 153 L L QPED+G Y R E N V + E P + T SP+ + G Sbjct: 1138 LTLPHAQPEDAGEYVCETRHEAITFN---------VILAEPPVQFLALETTPSPLCVAPG 1188 Query: 154 TEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGR 213 V +C + + W R V + E G L + + H Sbjct: 1189 EPVVLSCELS----RAGAPVVWSHN--GRPVQ-EGEGLELHAEGPRRVLCIQAAGPAHAG 1241 Query: 214 ILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNIL---PGELVTLTCQVNSSYPA 270 + CQ A +QV P V+++ + + + PG + L V+ S P Sbjct: 1242 LYTCQSGAAPGAPSLSFTVQVAEPP--VRVVAPEAAQTRVRSTPGGDLELV--VHLSGPG 1297 Query: 271 VSSIKWLKDGVRLQTK----------TGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPIS 320 ++W KDG RL ++ VL + A DAG Y C A P Sbjct: 1298 -GPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDA----------PQD 1346 Query: 321 LHIFMAEVQ-------VSPAGPIL--ENQTVTLVCNTPNEAPSDLRYSWYKN 363 IF+ V+ VS P+ E T C +P D +W +N Sbjct: 1347 SRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEV---SPPDADVTWLRN 1395 >gi|193794821 sialic acid binding Ig-like lectin 6 isoform 1 precursor [Homo sapiens] Length = 453 Score = 100 bits (248), Expect = 2e-20 Identities = 96/357 (26%), Positives = 152/357 (42%), Gaps = 44/357 (12%) Query: 4 LPKLL-LLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYD 62 LP LL LL + A + + + P+ + +G C+L+PC +P Y+ Sbjct: 13 LPLLLPLLWAGALAQERRFQLEGPESLTVQEGLCVLVPCRLP----TTLPASYYGYGYWF 68 Query: 63 YSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEV 122 G V+ + + V+ RGR + +P + C+L ++D + D+ +Y FR + + Sbjct: 69 LEGADVPVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWM 128 Query: 123 NRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPAR 182 V V P I+ P L G + CS P+VC Q G P Sbjct: 129 KYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQ--------GTPPI- 179 Query: 183 SVTFNSQKFEPTGVGHLETLHMAMSW----QDHGRILRCQLSV--ANHRAQSEIHLQVKY 236 F+ PT +G T ++ QDH L CQ++ A + I L V Y Sbjct: 180 ---FSWMSAAPTSLGPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSY 236 Query: 237 APKGV------------KILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ 284 AP+ V KIL + S +L G+ + L C + + PA + W + L Sbjct: 237 APQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPA--HLSWFQGFPALN 294 Query: 285 ----TKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPIL 337 + TGVL LPQ ++ G +TC+A++ +GSL ISL +F+ AG +L Sbjct: 295 ATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSL---QISLSLFVHWKPEGRAGGVL 348 Score = 54.7 bits (130), Expect = 8e-07 Identities = 53/186 (28%), Positives = 73/186 (39%), Gaps = 26/186 (13%) Query: 1093 PGATVREGQLVNLTCLV-WTTHPAQLT-YTWYQDGQQRLDAHSIPLPNVTVRD-----AT 1145 PG T+ G NLTC V W ++W L + +T+ +T Sbjct: 153 PG-TLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSLGPRTTQSSVLTITPRPQDHST 211 Query: 1146 SYRCGVGPPGRAPRLSRPITLDVLYAPRNLRL---------------TYLLESHGGQLAL 1190 + C V PG + R I L+V YAP+ + + T L GQ Sbjct: 212 NLTCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALR 271 Query: 1191 VLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQA 1250 +LC D PPA L+ L A + NT LEL +EG ++C A+ PLG Sbjct: 272 LLCDADGNPPAHLSWFQGFPAL---NATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSL 328 Query: 1251 NTSLEL 1256 SL L Sbjct: 329 QISLSL 334 Score = 50.8 bits (120), Expect = 1e-05 Identities = 49/193 (25%), Positives = 78/193 (40%), Gaps = 36/193 (18%) Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPLET----VTLLPVARTDAALY 772 TL+ G +NLTC+V G+P FSW + + GP T +T+ P + + Sbjct: 155 TLESGHPSNLTCSVPWVCEQGTPPIFSWM-SAAPTSLGPRTTQSSVLTITPRPQDHSTNL 213 Query: 773 ACRI-LTEAGAQLSTPVLLSVLYPPDRPKLSAL---------------LDMGQGHMALFI 816 C++ AG + + L+V Y P + +S L + +G + Sbjct: 214 TCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLL 273 Query: 817 CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRC 876 C D P A L+ F G L A +N+ LE+ ++G + G + C Sbjct: 274 CDADGNPPAHLSWFQGFPAL--------------NATPISNTGVLELPQVGSAEEGDFTC 319 Query: 877 EATNVLGSSNTSL 889 A + LGS SL Sbjct: 320 RAQHPLGSLQISL 332 Score = 45.4 bits (106), Expect = 5e-04 Identities = 55/236 (23%), Positives = 84/236 (35%), Gaps = 62/236 (26%) Query: 886 NTSLFFQVRGAWVQ--------------------VSPSPELQEGQAVVLSCQVHTGVPEG 925 N + FF+++ W++ +S L+ G L+C V +G Sbjct: 116 NAAYFFRLKSKWMKYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQG 175 Query: 926 TS--YRWYRDGQPLQESTSATLRFAAITLTQAGAYH-----CQAQAPGSATTSLAAPISL 978 T + W P T + + +T+T H CQ PG+ T + I L Sbjct: 176 TPPIFSWM-SAAPTSLGPRTT-QSSVLTITPRPQDHSTNLTCQVTFPGAGVT-MERTIQL 232 Query: 979 HVSYAPRHVTL---------------TTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRL 1023 +VSYAP+ V + T+ + G+ LLC D +PPA L G Sbjct: 233 NVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQG--- 289 Query: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASAS 1079 P L+ NT LE+ +EG + C A + LG S Sbjct: 290 --------------FPALNATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQIS 331 Score = 31.2 bits (69), Expect = 9.0 Identities = 19/67 (28%), Positives = 32/67 (47%), Gaps = 5/67 (7%) Query: 335 PILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLED---AHSHTLRLHLATRADTGFYFCE 391 P+LE Q + L+C+ P+ L SW++ L +++ L L A+ G + C Sbjct: 263 PVLEGQALRLLCDADGNPPAHL--SWFQGFPALNATPISNTGVLELPQVGSAEEGDFTCR 320 Query: 392 VQNVHGS 398 Q+ GS Sbjct: 321 AQHPLGS 327 >gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Homo sapiens] Length = 602 Score = 99.4 bits (246), Expect = 3e-20 Identities = 114/450 (25%), Positives = 182/450 (40%), Gaps = 70/450 (15%) Query: 5 PKLLLLASFFPAGQA-------SWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITA 57 P++LLL P A S+ + + V +G C+++ C S+P D D TA Sbjct: 11 PEMLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDGW--DESTA 68 Query: 58 IWYYDYSGQRQV-----VSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGS 112 + Y + G+ V+ + + VE R R + G+P C+L+++D Q ED Sbjct: 69 AYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAW 128 Query: 113 YNFRFEISEVNRWSDVKGT-LVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQV 171 Y FR E R S + + VT + P + P L G V C Sbjct: 129 YFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTVICV---------- 178 Query: 172 RLQWQGQD-PARSVTFNSQKFEP----TGVGHLETLHMAMSWQDHGRILRCQLSVANH-- 224 W + PA S ++ P H L S QDH L C + + Sbjct: 179 -FNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGV 237 Query: 225 RAQSEIHLQVKYAPKGVKILLSPSGRNIL------------PGELVTLTCQVNSSYPAVS 272 AQ + L+V YAPK + I +S + L G+ + L C +S PA Sbjct: 238 SAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPA-- 295 Query: 273 SIKW-LKDGVRLQT-----KTGVLHLPQAAWSDAGVYTCQAENGVG--------SLVSPP 318 ++ W L+D V + +T L L D+G YTC+AEN +G S+ PP Sbjct: 296 TLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPP 355 Query: 319 ISLHIFMAEVQVS--------PAGPILENQTVTLVCNTPNEAPSDLRYS-WYKNHVLLED 369 +L + +++ + + P+LE Q++ LVC T + P+ L ++ W + + Sbjct: 356 ENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQP 415 Query: 370 AHSHTLRLHLATRADTGFYFCEVQNVHGSE 399 + L L G + C Q+ GS+ Sbjct: 416 SDPGVLELPPIQMEHEGEFTCHAQHPLGSQ 445 Score = 67.4 bits (163), Expect = 1e-10 Identities = 61/224 (27%), Positives = 93/224 (41%), Gaps = 37/224 (16%) Query: 1145 TSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY---------------LLESHGGQLA 1189 T C V + R + L V YAP++L ++ LE GQ Sbjct: 224 TDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFL 283 Query: 1190 LVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQ 1249 +LC DS+PPA L+ R+L+SS P TL LELRG + D G Y+C A + LG Sbjct: 284 RLLCAADSQPPATLSWVLQDRVLSSSHPWG-PRTLGLELRGVRAGDSGRYTCRAENRLGS 342 Query: 1250 ANTSLELRL----EGVRVILA-------------PEAAVPEGAPITVTCADPAAHAPTLY 1292 +L+L + E +RV+++ V EG + + C ++ P Sbjct: 343 QQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSS-PPARL 401 Query: 1293 TWYHNGRWL---QEGPAASLSFLVATRAHAGAYSCQAQDAQGTR 1333 +W G+ + Q L H G ++C AQ G++ Sbjct: 402 SWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQ 445 Score = 65.1 bits (157), Expect = 6e-10 Identities = 100/399 (25%), Positives = 148/399 (37%), Gaps = 92/399 (23%) Query: 634 LQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYL--CEA 691 +++ +DR T P G CS + I + E+E Y E Sbjct: 95 VEMSTRDRFQLTGDPGKGSCS-------------------LVIRDAQREDEAWYFFRVER 135 Query: 692 SNALGNASTSATFNGQATVLAIAPS----HTLQEGTEANLTCNVSREAAGSPA-NFSWFR 746 + + ++ S F + T L P TL+ G + C + PA +FSW Sbjct: 136 GSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSW-- 193 Query: 747 NGVLWAQGPLET---------VTLLPVARTDAALYACRI-LTEAGAQLSTPVLLSVLYPP 796 G A P T ++ P + C + + G V L V Y P Sbjct: 194 TGA--ALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAP 251 Query: 797 -------DRPKLSAL--------LDMGQGHMALFICTVDSRPLALLALFHGEHLLATS-- 839 SAL L++ +G +C DS+P A L+ + +L++S Sbjct: 252 KDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHP 311 Query: 840 LGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR----G 895 GP+ +L LE+R + GDSG Y C A N LGS +L V+ Sbjct: 312 WGPR--------------TLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPEN 357 Query: 896 AWVQVS-------------PSPELQEGQAVVLSCQVHTGVPEGTSY-RWYRDGQPLQEST 941 V VS S + EGQ++ L C H+ P S+ RW + P Q S Sbjct: 358 LRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSD 417 Query: 942 SATLRFAAITLTQAGAYHCQAQAP-GSATTSLAAPISLH 979 L I + G + C AQ P GS SL+ +S+H Sbjct: 418 PGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLS--LSVH 454 Score = 64.7 bits (156), Expect = 7e-10 Identities = 93/398 (23%), Positives = 148/398 (37%), Gaps = 78/398 (19%) Query: 843 QVPSHGRFQAKAEAN--SLKLEVRELGLGDSGSY--RCEATNVLGSSNTSLFFQVRGAWV 898 ++ + RFQ + S L +R+ D Y R E + + S S F ++ + Sbjct: 96 EMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTAL 155 Query: 899 QVSPS---PE-LQEGQAVVLSCQVHTGVPE--GTSYRWYRDGQPLQESTSATLRFAAITL 952 P PE L+ GQ V + C + + S+ W + + +T F+ ++ Sbjct: 156 TKKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSF 215 Query: 953 TQAGAYH-----CQAQAPGSATTSLAAPISLHVSYAPRHVTLTT---------------L 992 T + H C S + L V+YAP+ + ++ Sbjct: 216 TPSPQDHDTDLTCHVDFSRKGV-SAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIY 274 Query: 993 MDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRL 1052 ++ G+ LLC DS PPA L + DR+++S+ P G P TL L Sbjct: 275 LEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSS-----HPWG----------PRTLGL 319 Query: 1053 EIHGAMLEDEGVYICEASNTLGQASASADFDAQ-----------------AVNVQVWPGA 1095 E+ G D G Y C A N LG + D Q N+ Sbjct: 320 ELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSL 379 Query: 1096 TVREGQLVNLTCLVWTTHPAQLTYT-WYQ--DGQQRLDAHSIPLPNVTVRDATSYRCGVG 1152 V EGQ + L C+ ++ PA+L++T W Q Q D + LP + + + C Sbjct: 380 PVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQ 439 Query: 1153 PPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLAL 1190 P L + +L + + LE HGG L L Sbjct: 440 HP-----------LGSQHVSLSLSVHWKLE-HGGGLGL 465 Score = 56.6 bits (135), Expect = 2e-07 Identities = 54/179 (30%), Positives = 74/179 (41%), Gaps = 33/179 (18%) Query: 420 FLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIR 479 +LE Q G L C+ S+P ATL +L+S S GP +L LE+R Sbjct: 274 YLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSS-----------SHPWGPRTLGLELR 322 Query: 480 DLEETDSGEYKCSATNSLGNATSTLD----FHANAARLLISPA-------------AEVV 522 + DSG Y C A N LG+ LD + R+++S A V+ Sbjct: 323 GVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVL 382 Query: 523 EGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSS---LLLPAASSTDAGSYHCRAR 578 EGQ++ L C + S P AR SW G + S L LP G + C A+ Sbjct: 383 EGQSLRLVCVTHSS--PPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQ 439 Score = 54.7 bits (130), Expect = 8e-07 Identities = 87/345 (25%), Positives = 128/345 (37%), Gaps = 67/345 (19%) Query: 1226 LELRGPQPRDEG--FYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE----GAPITV 1279 L +R Q DE F+ S + + S L+ + P+ +PE G P+TV Sbjct: 116 LVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTV 175 Query: 1280 TC----ADPAAHAPTLYTWYHNGRWL---QEGPAAS----LSFLVATRAHAGAYSCQAQ- 1327 C A AP+ ++W G L + P+ S LSF + + H +C Sbjct: 176 ICVFNWAFKKCPAPS-FSW--TGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDF 232 Query: 1328 DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR---------------SMAVIQCTVDSE 1372 +G + R L+V YAP+D ++S D+ + + C DS+ Sbjct: 233 SRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQ 292 Query: 1373 PPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLL 1431 PPA L+ +VL++S H T L L+++ V AGD Y C A+N L Sbjct: 293 PPATLSWVLQDRVLSSS---HPWGPRT---------LGLELRGVRAGDSGRYTCRAENRL 340 Query: 1432 GSISTIGRLQV----EGARVVAE-------------PGLDVPEGAALNLSCRLLGGPGPV 1474 GS L V E RV+ L V EG +L L C P P Sbjct: 341 GSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSP-PA 399 Query: 1475 GNSTFAWFWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGA 1519 S W L + G + C A+ P G+ Sbjct: 400 RLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGS 444 Score = 53.5 bits (127), Expect = 2e-06 Identities = 51/182 (28%), Positives = 77/182 (42%), Gaps = 29/182 (15%) Query: 1097 VREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH-------SIPLPNVTVRDATSYRC 1149 V++GQ + L C + PA T +W + +H + L V D+ Y C Sbjct: 277 VQKGQFLRLLCAADSQPPA--TLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTC 334 Query: 1150 GVGPPGRAPRLSRPITLDVLYAPRNLRLTY------LLESHG---------GQLALVLCT 1194 R + + L V Y P NLR+ +LE+ G GQ ++C Sbjct: 335 RA--ENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCV 392 Query: 1195 VDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSL 1254 S PPA+L+ + G+ + S + P L EL Q EG ++C A+ PLG + SL Sbjct: 393 THSSPPARLSWTRWGQTVGPSQPSD-PGVL--ELPPIQMEHEGEFTCHAQHPLGSQHVSL 449 Query: 1255 EL 1256 L Sbjct: 450 SL 451 Score = 50.1 bits (118), Expect = 2e-05 Identities = 36/119 (30%), Positives = 53/119 (44%), Gaps = 27/119 (22%) Query: 1518 GAAASAPVMLRVLYPPKTPTM---------------MVFVEPEGGLRGILDCRVDSEPLA 1562 G +A V LRV Y PK + ++++E + G L C DS+P A Sbjct: 236 GVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPA 295 Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621 +L+ L R+++SS P G P L +++ +R D G Y C A N LGS Sbjct: 296 TLSWVLQDRVLSSSHPWG------------PRTLGLELRGVRAGDSGRYTCRAENRLGS 342 Score = 48.9 bits (115), Expect = 4e-05 Identities = 89/372 (23%), Positives = 125/372 (33%), Gaps = 82/372 (22%) Query: 464 RFSGTSGPNSLRLEIRDLEETDSGEY--KCSATNSLGNATSTLDFHANAARLLISPAAEV 521 + +G G S L IRD + D Y + + + ++ + F L P + Sbjct: 104 QLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYI 163 Query: 522 VE----GQAVTLSC--RSGLSPTPDARFSWYLNGALL----------HEGPGSSLLLPAA 565 E GQ VT+ C P FSW GA L H S P Sbjct: 164 PETLEPGQPVTVICVFNWAFKKCPAPSFSW--TGAALSPRRTRPSTSHFSVLSFTPSPQD 221 Query: 566 SSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAA----------GAG 615 TD + +R G SA L V Y P+ + D +A Sbjct: 222 HDTDLTCHVDFSRKGVSAQ---RTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQ 278 Query: 616 AGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVE 675 G+ LLC DS PPA L + +DRV+++S P G P L +E Sbjct: 279 KGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWG------------------PRTLGLE 320 Query: 676 IHNPLLEEEGLYLCEASNALGNASTSATFNGQ--------------ATVLAIAPSHT--- 718 + + G Y C A N LG+ + + Q TVL + T Sbjct: 321 LRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLP 380 Query: 719 LQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQ--GPLE-----TVTLLPVARTDAAL 771 + EG L C + PA SW R W Q GP + + L P+ Sbjct: 381 VLEGQSLRLVCVTH---SSPPARLSWTR----WGQTVGPSQPSDPGVLELPPIQMEHEGE 433 Query: 772 YACRILTEAGAQ 783 + C G+Q Sbjct: 434 FTCHAQHPLGSQ 445 Score = 38.1 bits (87), Expect = 0.074 Identities = 50/198 (25%), Positives = 71/198 (35%), Gaps = 39/198 (19%) Query: 1453 LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP-----VPTLAFTHVARAQAG 1507 L+V +G L L C P +T +W DR L + L V +G Sbjct: 275 LEVQKGQFLRLLCAADSQPP----ATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSG 330 Query: 1508 MYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI---------------L 1552 Y C AE G+ A + L V YPP+ +MV L + L Sbjct: 331 RYTCRAENRLGSQQQA-LDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRL 389 Query: 1553 DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612 C S P A L+ + V SQP + P L ++ ++ +GE+ Sbjct: 390 VCVTHSSPPARLSWTRWGQTVGPSQP------------SDPGVL--ELPPIQMEHEGEFT 435 Query: 1613 CSASNVLGSASTSTYFGV 1630 C A + LGS S V Sbjct: 436 CHAQHPLGSQHVSLSLSV 453 Score = 32.3 bits (72), Expect = 4.1 Identities = 45/184 (24%), Positives = 71/184 (38%), Gaps = 36/184 (19%) Query: 336 ILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHS---HTLRLHL--ATRADTGFYFC 390 + + Q + L+C ++ P+ L SW +L +H TL L L D+G Y C Sbjct: 277 VQKGQFLRLLCAADSQPPATL--SWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTC 334 Query: 391 EVQNVHGSERSGPVSVVVNHPP------LTPVLTAFLETQAGLVGI---------LHCSV 435 +N GS++ + + V +PP ++ LE + L C Sbjct: 335 RAENRLGSQQQA-LDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVT 393 Query: 436 VSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATN 495 S P A L + G T G S P G LE+ ++ GE+ C A + Sbjct: 394 HSSPPARLSWTRWG----QTVGPS--QPSDPGV-------LELPPIQMEHEGEFTCHAQH 440 Query: 496 SLGN 499 LG+ Sbjct: 441 PLGS 444 >gi|193794817 sialic acid binding Ig-like lectin 6 isoform 3 precursor [Homo sapiens] Length = 353 Score = 99.0 bits (245), Expect = 4e-20 Identities = 93/345 (26%), Positives = 148/345 (42%), Gaps = 44/345 (12%) Query: 4 LPKLL-LLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYD 62 LP LL LL + A + + + P+ + +G C+L+PC +P Y+ Sbjct: 13 LPLLLPLLWAGALAQERRFQLEGPESLTVQEGLCVLVPCRLP----TTLPASYYGYGYWF 68 Query: 63 YSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEV 122 G V+ + + V+ RGR + +P + C+L ++D + D+ +Y FR + + Sbjct: 69 LEGADVPVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWM 128 Query: 123 NRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPAR 182 V V P I+ P L G + CS P+VC Q G P Sbjct: 129 KYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQ--------GTPPI- 179 Query: 183 SVTFNSQKFEPTGVGHLETLHMAMSW----QDHGRILRCQLSV--ANHRAQSEIHLQVKY 236 F+ PT +G T ++ QDH L CQ++ A + I L V Y Sbjct: 180 ---FSWMSAAPTSLGPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSY 236 Query: 237 APKGV------------KILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ 284 AP+ V KIL + S +L G+ + L C + + PA + W + L Sbjct: 237 APQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPA--HLSWFQGFPALN 294 Query: 285 ----TKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFM 325 + TGVL LPQ ++ G +TC+A++ +GSL ISL +F+ Sbjct: 295 ATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSL---QISLSLFV 336 Score = 54.7 bits (130), Expect = 8e-07 Identities = 53/186 (28%), Positives = 73/186 (39%), Gaps = 26/186 (13%) Query: 1093 PGATVREGQLVNLTCLV-WTTHPAQLT-YTWYQDGQQRLDAHSIPLPNVTVRD-----AT 1145 PG T+ G NLTC V W ++W L + +T+ +T Sbjct: 153 PG-TLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSLGPRTTQSSVLTITPRPQDHST 211 Query: 1146 SYRCGVGPPGRAPRLSRPITLDVLYAPRNLRL---------------TYLLESHGGQLAL 1190 + C V PG + R I L+V YAP+ + + T L GQ Sbjct: 212 NLTCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALR 271 Query: 1191 VLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQA 1250 +LC D PPA L+ L A + NT LEL +EG ++C A+ PLG Sbjct: 272 LLCDADGNPPAHLSWFQGFPAL---NATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSL 328 Query: 1251 NTSLEL 1256 SL L Sbjct: 329 QISLSL 334 Score = 50.8 bits (120), Expect = 1e-05 Identities = 49/193 (25%), Positives = 78/193 (40%), Gaps = 36/193 (18%) Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPLET----VTLLPVARTDAALY 772 TL+ G +NLTC+V G+P FSW + + GP T +T+ P + + Sbjct: 155 TLESGHPSNLTCSVPWVCEQGTPPIFSWM-SAAPTSLGPRTTQSSVLTITPRPQDHSTNL 213 Query: 773 ACRI-LTEAGAQLSTPVLLSVLYPPDRPKLSAL---------------LDMGQGHMALFI 816 C++ AG + + L+V Y P + +S L + +G + Sbjct: 214 TCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLL 273 Query: 817 CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRC 876 C D P A L+ F G L A +N+ LE+ ++G + G + C Sbjct: 274 CDADGNPPAHLSWFQGFPAL--------------NATPISNTGVLELPQVGSAEEGDFTC 319 Query: 877 EATNVLGSSNTSL 889 A + LGS SL Sbjct: 320 RAQHPLGSLQISL 332 Score = 45.4 bits (106), Expect = 5e-04 Identities = 55/236 (23%), Positives = 84/236 (35%), Gaps = 62/236 (26%) Query: 886 NTSLFFQVRGAWVQ--------------------VSPSPELQEGQAVVLSCQVHTGVPEG 925 N + FF+++ W++ +S L+ G L+C V +G Sbjct: 116 NAAYFFRLKSKWMKYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQG 175 Query: 926 TS--YRWYRDGQPLQESTSATLRFAAITLTQAGAYH-----CQAQAPGSATTSLAAPISL 978 T + W P T + + +T+T H CQ PG+ T + I L Sbjct: 176 TPPIFSWM-SAAPTSLGPRTT-QSSVLTITPRPQDHSTNLTCQVTFPGAGVT-MERTIQL 232 Query: 979 HVSYAPRHVTL---------------TTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRL 1023 +VSYAP+ V + T+ + G+ LLC D +PPA L G Sbjct: 233 NVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQG--- 289 Query: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASAS 1079 P L+ NT LE+ +EG + C A + LG S Sbjct: 290 --------------FPALNATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQIS 331 Score = 31.2 bits (69), Expect = 9.0 Identities = 19/67 (28%), Positives = 32/67 (47%), Gaps = 5/67 (7%) Query: 335 PILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLED---AHSHTLRLHLATRADTGFYFCE 391 P+LE Q + L+C+ P+ L SW++ L +++ L L A+ G + C Sbjct: 263 PVLEGQALRLLCDADGNPPAHL--SWFQGFPALNATPISNTGVLELPQVGSAEEGDFTCR 320 Query: 392 VQNVHGS 398 Q+ GS Sbjct: 321 AQHPLGS 327 >gi|193794819 sialic acid binding Ig-like lectin 6 isoform 2 precursor [Homo sapiens] Length = 437 Score = 96.7 bits (239), Expect = 2e-19 Identities = 90/343 (26%), Positives = 147/343 (42%), Gaps = 32/343 (9%) Query: 4 LPKLL-LLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYD 62 LP LL LL + A + + + P+ + +G C+L+PC +P Y+ Sbjct: 13 LPLLLPLLWAGALAQERRFQLEGPESLTVQEGLCVLVPCRLP----TTLPASYYGYGYWF 68 Query: 63 YSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEV 122 G V+ + + V+ RGR + +P + C+L ++D + D+ +Y FR + + Sbjct: 69 LEGADVPVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWM 128 Query: 123 NRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPAR 182 V V P I+ P L G + CS P+VC Q G P Sbjct: 129 KYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQ--------GTPPI- 179 Query: 183 SVTFNSQKFEPTGVGHLETLHMAMSW----QDHGRILRCQLSVANHRAQSEIHLQVKYAP 238 F+ PT +G T ++ QDH L CQ++ E +Q+ + Sbjct: 180 ---FSWMSAAPTSLGPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVS- 235 Query: 239 KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ----TKTGVLHLPQ 294 KIL + S +L G+ + L C + + PA + W + L + TGVL LPQ Sbjct: 236 -SFKILQNTSSLPVLEGQALRLLCDADGNPPA--HLSWFQGFPALNATPISNTGVLELPQ 292 Query: 295 AAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPIL 337 ++ G +TC+A++ +GSL ISL +F+ AG +L Sbjct: 293 VGSAEEGDFTCRAQHPLGSL---QISLSLFVHWKPEGRAGGVL 332 Score = 51.2 bits (121), Expect = 8e-06 Identities = 51/171 (29%), Positives = 71/171 (41%), Gaps = 12/171 (7%) Query: 1093 PGATVREGQLVNLTCLV-WTTHPAQLT-YTWYQDGQQRLDAHSIPLPNVTVRD-----AT 1145 PG T+ G NLTC V W ++W L + +T+ +T Sbjct: 153 PG-TLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSLGPRTTQSSVLTITPRPQDHST 211 Query: 1146 SYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLAL 1205 + C V PG + R I L+V + + L+ T L GQ +LC D PPA L+ Sbjct: 212 NLTCQVTFPGAGVTMERTIQLNVS-SFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSW 270 Query: 1206 SHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLEL 1256 L A + NT LEL +EG ++C A+ PLG SL L Sbjct: 271 FQGFPAL---NATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQISLSL 318 Score = 46.2 bits (108), Expect = 3e-04 Identities = 47/178 (26%), Positives = 75/178 (42%), Gaps = 22/178 (12%) Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPLET----VTLLPVARTDAALY 772 TL+ G +NLTC+V G+P FSW + + GP T +T+ P + + Sbjct: 155 TLESGHPSNLTCSVPWVCEQGTPPIFSWM-SAAPTSLGPRTTQSSVLTITPRPQDHSTNL 213 Query: 773 ACRI-LTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFH 831 C++ AG + + L+V S+L + +G +C D P A L+ F Sbjct: 214 TCQVTFPGAGVTMERTIQLNVSSFKILQNTSSLPVL-EGQALRLLCDADGNPPAHLSWFQ 272 Query: 832 GEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSL 889 G L A +N+ LE+ ++G + G + C A + LGS SL Sbjct: 273 GFPAL--------------NATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQISL 316 Score = 38.9 bits (89), Expect = 0.043 Identities = 51/221 (23%), Positives = 81/221 (36%), Gaps = 48/221 (21%) Query: 886 NTSLFFQVRGAWVQ--------------------VSPSPELQEGQAVVLSCQVHTGVPEG 925 N + FF+++ W++ +S L+ G L+C V +G Sbjct: 116 NAAYFFRLKSKWMKYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQG 175 Query: 926 TS--YRWYRDGQPLQESTSATLRFAAITLTQAGAYH-----CQAQAPGSATTSLAAPISL 978 T + W P T + + +T+T H CQ PG+ T + I L Sbjct: 176 TPPIFSWM-SAAPTSLGPRTT-QSSVLTITPRPQDHSTNLTCQVTFPGAGVT-MERTIQL 232 Query: 979 HVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSS 1038 +VS + + + T+ + G+ LLC D +PPA L G Sbjct: 233 NVS-SFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQG-----------------F 274 Query: 1039 PRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASAS 1079 P L+ NT LE+ +EG + C A + LG S Sbjct: 275 PALNATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQIS 315 Score = 35.8 bits (81), Expect = 0.37 Identities = 30/119 (25%), Positives = 54/119 (45%), Gaps = 7/119 (5%) Query: 285 TKTGVLHLPQAAWSDAGVYTCQAE-NGVGSLVSPPISLHIFMAEV-QVSPAGPILENQTV 342 T++ VL + + TCQ G G + I L++ ++ Q + + P+LE Q + Sbjct: 195 TQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSSFKILQNTSSLPVLEGQAL 254 Query: 343 TLVCNTPNEAPSDLRYSWYKNHVLLED---AHSHTLRLHLATRADTGFYFCEVQNVHGS 398 L+C+ P+ L SW++ L +++ L L A+ G + C Q+ GS Sbjct: 255 RLLCDADGNPPAHL--SWFQGFPALNATPISNTGVLELPQVGSAEEGDFTCRAQHPLGS 311 >gi|23943856 sialic acid binding Ig-like lectin 9 [Homo sapiens] Length = 463 Score = 96.3 bits (238), Expect = 2e-19 Identities = 89/323 (27%), Positives = 135/323 (41%), Gaps = 37/323 (11%) Query: 17 GQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSG----QRQVVSH 72 GQ S ++ V +G C+ +PC FS+P+ + G Y+ G Q V+ Sbjct: 17 GQTSKLLTMQSSVTVQEGLCVHVPCSFSYPSHGWIYPGPVVHGYWFREGANTDQDAPVAT 76 Query: 73 SADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTL 132 + + V R R +G+P + C L ++D + D+G Y FR E + +W+ L Sbjct: 77 NNPARAVWEETRDRFHLLGDPHTKNCTLSIRDARRSDAGRYFFRMEKGSI-KWNYKHHRL 135 Query: 133 -VTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKF 191 V VT P I P L G + CS P+ C QG P S S Sbjct: 136 SVNVTALTHRPNILIPGTLESGCPQNLTCSVPWAC--------EQGTPPMISWIGTSVSP 187 Query: 192 EPTGVGHLETLHMAMSWQDHGRILRCQLSV--ANHRAQSEIHLQVKYAPKGV-------- 241 L + QDHG L CQ++ A+ +HL V Y P+ + Sbjct: 188 LDPSTTRSSVLTLIPQPQDHGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGD 247 Query: 242 ----KILLSPSGRNILPGELVTLTC---QVNSSYPAVSSIKWLKDGVRL----QTKTGVL 290 +L + S ++ G+ + L C V+S+ PA S+ W G+ L + GVL Sbjct: 248 GTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSLSW--RGLTLCPSQPSNPGVL 305 Query: 291 HLPQAAWSDAGVYTCQAENGVGS 313 LP DA +TC+A+N +GS Sbjct: 306 ELPWVHLRDAAEFTCRAQNPLGS 328 Score = 54.7 bits (130), Expect = 8e-07 Identities = 72/263 (27%), Positives = 98/263 (37%), Gaps = 47/263 (17%) Query: 1035 EGSSPRLHVAVAPNTLR--LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVW 1092 E + R H+ P+T L I A D G Y G + +VNV Sbjct: 85 EETRDRFHLLGDPHTKNCTLSIRDARRSDAGRYFFRMEK--GSIKWNYKHHRLSVNVTAL 142 Query: 1093 --------PGATVREGQLVNLTCLV-WTTHPAQLTY-TWYQDGQQRLDAHS--------I 1134 PG T+ G NLTC V W +W LD + I Sbjct: 143 THRPNILIPG-TLESGCPQNLTCSVPWACEQGTPPMISWIGTSVSPLDPSTTRSSVLTLI 201 Query: 1135 PLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY--------------- 1179 P P TS C V PG + ++ + L+V Y P+NL +T Sbjct: 202 PQPQ---DHGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGS 258 Query: 1180 ---LLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDE 1236 L E +L + VDS PPA+L+LS G L S + N LEL RD Sbjct: 259 SLSLPEGQSLRLVCAVDAVDSNPPARLSLSWRGLTLCPSQPS---NPGVLELPWVHLRDA 315 Query: 1237 GFYSCSARSPLGQANTSLELRLE 1259 ++C A++PLG L + L+ Sbjct: 316 AEFTCRAQNPLGSQQVYLNVSLQ 338 Score = 46.6 bits (109), Expect = 2e-04 Identities = 55/200 (27%), Positives = 78/200 (39%), Gaps = 47/200 (23%) Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPLE-------TVTLLPVARTDA 769 TL+ G NLTC+V G+P SW V PL+ +TL+P + Sbjct: 153 TLESGCPQNLTCSVPWACEQGTPPMISWIGTSV----SPLDPSTTRSSVLTLIPQPQDHG 208 Query: 770 ALYACRILTEAGAQLST--PVLLSVLYPPDRPKLSAL---------------LDMGQGHM 812 C++ T GA ++T V L+V YPP ++ L + +G Sbjct: 209 TSLTCQV-TFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQS 267 Query: 813 ALFICTVD---SRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869 +C VD S P A L+L +L P PS N LE+ + L Sbjct: 268 LRLVCAVDAVDSNPPARLSL----SWRGLTLCPSQPS----------NPGVLELPWVHLR 313 Query: 870 DSGSYRCEATNVLGSSNTSL 889 D+ + C A N LGS L Sbjct: 314 DAAEFTCRAQNPLGSQQVYL 333 Score = 42.0 bits (97), Expect = 0.005 Identities = 52/205 (25%), Positives = 79/205 (38%), Gaps = 43/205 (20%) Query: 906 LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYH-----C 960 L+ G L+C V +GT G + +T R + +TL H C Sbjct: 154 LESGCPQNLTCSVPWACEQGTPPMISWIGTSVSPLDPSTTRSSVLTLIPQPQDHGTSLTC 213 Query: 961 QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTG---------------PGRLGLLLC 1005 Q PG++ T+ + L+VSY P+++T+T G G+ L+C Sbjct: 214 QVTFPGASVTTNKT-VHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVC 272 Query: 1006 ---RVDSDPPAQLRL-LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061 VDS+PPA+L L G L S + S+P + LE+ L D Sbjct: 273 AVDAVDSNPPARLSLSWRGLTLCPS--------QPSNPGV----------LELPWVHLRD 314 Query: 1062 EGVYICEASNTLGQASASADFDAQA 1086 + C A N LG + Q+ Sbjct: 315 AAEFTCRAQNPLGSQQVYLNVSLQS 339 Score = 33.5 bits (75), Expect = 1.8 Identities = 48/195 (24%), Positives = 73/195 (37%), Gaps = 39/195 (20%) Query: 1264 ILAPEAAVPEGAPITVTCADPAA---HAPTLYTWYHNG-RWLQEGPAAS--LSFLVATRA 1317 IL P + G P +TC+ P A P + +W L S L+ + + Sbjct: 148 ILIP-GTLESGCPQNLTCSVPWACEQGTPPMISWIGTSVSPLDPSTTRSSVLTLIPQPQD 206 Query: 1318 HAGAYSCQAQ-DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV------------ 1364 H + +CQ +++ L V Y PQ+ ++ F+ S + Sbjct: 207 HGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQ 266 Query: 1365 ---IQCTVD---SEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPA 1418 + C VD S PPA L+LS G L S S G +++ LR + Sbjct: 267 SLRLVCAVDAVDSNPPARLSLSWRGLTLCPSQ-----PSNPGVLELPWVHLRDAAE---- 317 Query: 1419 GDDTYVCTAQNLLGS 1433 + C AQN LGS Sbjct: 318 ----FTCRAQNPLGS 328 Score = 32.0 bits (71), Expect = 5.3 Identities = 37/115 (32%), Positives = 45/115 (39%), Gaps = 32/115 (27%) Query: 1525 VMLRVLYPPKTPTMMVFVE----------------PEG-GLRGILDC-RVDSEPLASLTL 1566 V L V YPP+ TM VF PEG LR + VDS P A L+L Sbjct: 228 VHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSL 287 Query: 1567 HLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621 + SQP ++P L + LR D E+ C A N LGS Sbjct: 288 SWRGLTLCPSQP------------SNPGVLELPWVHLR--DAAEFTCRAQNPLGS 328 >gi|94538343 sialic acid binding Ig-like lectin 8 [Homo sapiens] Length = 499 Score = 96.3 bits (238), Expect = 2e-19 Identities = 103/401 (25%), Positives = 163/401 (40%), Gaps = 48/401 (11%) Query: 33 KGSCLLIPCIFSFPADVEVP-DGITAIWYY--DYSGQRQVVSHSADPKLVEARFRGRTEF 89 +G C+ +PC FS+P D D + W+ D Q V+ + + V+A +GR + Sbjct: 39 EGLCVHVPCSFSYPQDGWTDSDPVHGYWFRAGDRPYQDAPVATNNPDREVQAETQGRFQL 98 Query: 90 MGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWS-------DVKGTLVTVTEEPRVP 142 +G+ C+L ++D + D GSY FR E + +WS K V VT P Sbjct: 99 LGDIWSNDCSLSIRDARKRDKGSYFFRLERGSM-KWSYKSQLNYKTKQLSVFVTALTHRP 157 Query: 143 TIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETL 202 I L G + CS P+ C QG P S S L Sbjct: 158 DILILGTLESGHSRNLTCSVPWACK--------QGTPPMISWIGASVSSPGPTTARSSVL 209 Query: 203 HMAMSWQDHGRILRCQLSV--ANHRAQSEIHLQVKYAPKGVKI------------LLSPS 248 + QDHG L CQ+++ S + L V Y P + + L + S Sbjct: 210 TLTPKPQDHGTSLTCQVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGS 269 Query: 249 GRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRL----QTKTGVLHLPQAAWSDAGVYT 304 ++L G+ + L C VNS+ PA + W + + L + G+L LP+ D G +T Sbjct: 270 SLSVLEGQSLRLVCAVNSNPPA--RLSWTRGSLTLCPSRSSNPGLLELPRVHVRDEGEFT 327 Query: 305 CQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNH 364 C+A+N G S ISL + + + P+ + VTL A + S+ Sbjct: 328 CRAQNAQG---SQHISLSLSLQNEGTGTSRPVSQ---VTLAAVGGAGATALAFLSFCIIF 381 Query: 365 VLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVS 405 +++ + R A DTG + + + GS GP++ Sbjct: 382 IIVRSCRKKSAR-PAAGVGDTGME--DAKAIRGSASQGPLT 419 Score = 63.2 bits (152), Expect = 2e-09 Identities = 68/276 (24%), Positives = 104/276 (37%), Gaps = 51/276 (18%) Query: 843 QVPSHGRFQAKAE--ANSLKLEVRELGLGDSGSY--RCEATNVLGSSNTSLFFQVRGAWV 898 Q + GRFQ + +N L +R+ D GSY R E ++ S + L ++ + V Sbjct: 89 QAETQGRFQLLGDIWSNDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTKQLSV 148 Query: 899 QVSPSPE---------LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAA 949 V+ L+ G + L+C V +GT G + T R + Sbjct: 149 FVTALTHRPDILILGTLESGHSRNLTCSVPWACKQGTPPMISWIGASVSSPGPTTARSSV 208 Query: 950 ITLTQAGAYH-----CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL-- 1002 +TLT H CQ PG+ T+ + + L VSY P ++T+T L Sbjct: 209 LTLTPKPQDHGTSLTCQVTLPGTGVTTTST-VRLDVSYPPWNLTMTVFQGDATASTALGN 267 Query: 1003 -------------LLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNT 1049 L+C V+S+PPA+L G + + S+P L Sbjct: 268 GSSLSVLEGQSLRLVCAVNSNPPARLSWTRGSLTLCPS-------RSSNPGL-------- 312 Query: 1050 LRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQ 1085 LE+ + DEG + C A N G S Q Sbjct: 313 --LELPRVHVRDEGEFTCRAQNAQGSQHISLSLSLQ 346 Score = 55.5 bits (132), Expect = 4e-07 Identities = 62/245 (25%), Positives = 93/245 (37%), Gaps = 36/245 (14%) Query: 1048 NTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGA-----------T 1096 N L I A D+G Y + S + + + + V+ A T Sbjct: 105 NDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGT 164 Query: 1097 VREGQLVNLTCLV-WTTH---PAQLTY---TWYQDGQQRLDAHSIPLPNVTVRDATSYRC 1149 + G NLTC V W P +++ + G + + L TS C Sbjct: 165 LESGHSRNLTCSVPWACKQGTPPMISWIGASVSSPGPTTARSSVLTLTPKPQDHGTSLTC 224 Query: 1150 GVGPPGRAPRLSRPITLDVLYAPRNLRLTYL---------------LESHGGQLALVLCT 1194 V PG + + LDV Y P NL +T L GQ ++C Sbjct: 225 QVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVCA 284 Query: 1195 VDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSL 1254 V+S PPA+L+ + L S ++ N LEL RDEG ++C A++ G + SL Sbjct: 285 VNSNPPARLSWTRGSLTLCPSRSS---NPGLLELPRVHVRDEGEFTCRAQNAQGSQHISL 341 Query: 1255 ELRLE 1259 L L+ Sbjct: 342 SLSLQ 346 Score = 51.6 bits (122), Expect = 6e-06 Identities = 53/193 (27%), Positives = 75/193 (38%), Gaps = 36/193 (18%) Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPL----ETVTLLPVARTDAALY 772 TL+ G NLTC+V G+P SW V + GP +TL P + Sbjct: 164 TLESGHSRNLTCSVPWACKQGTPPMISWIGASVS-SPGPTTARSSVLTLTPKPQDHGTSL 222 Query: 773 ACRI-LTEAGAQLSTPVLLSVLYPP----------DRPKLSAL-----LDMGQGHMALFI 816 C++ L G ++ V L V YPP D +AL L + +G + Sbjct: 223 TCQVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLV 282 Query: 817 CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRC 876 C V+S P A L+ G L S +N LE+ + + D G + C Sbjct: 283 CAVNSNPPARLSWTRGSLTLCPS--------------RSSNPGLLELPRVHVRDEGEFTC 328 Query: 877 EATNVLGSSNTSL 889 A N GS + SL Sbjct: 329 RAQNAQGSQHISL 341 Score = 42.0 bits (97), Expect = 0.005 Identities = 67/268 (25%), Positives = 94/268 (35%), Gaps = 58/268 (21%) Query: 472 NSLRLEIRDLEETDSGEY---------KCSATNSLGNATSTLDFHANAAR----LLISPA 518 N L IRD + D G Y K S + L T L A +LI Sbjct: 105 NDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGT 164 Query: 519 AEVVEGQAVTLS----CRSGLSPTPDARFSWYLNGALLHEGPG---SSLLLPAASSTDAG 571 E + +T S C+ G P SW + ++ GP SS+L D G Sbjct: 165 LESGHSRNLTCSVPWACKQGTPPM----ISW-IGASVSSPGPTTARSSVLTLTPKPQDHG 219 Query: 572 -SYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGA-----------GRR 619 S C+ + +S L V YPP T T DA + A G+ Sbjct: 220 TSLTCQVTLPGTGVTTTSTVRLDVSYPPWNLTMTV-FQGDATASTALGNGSSLSVLEGQS 278 Query: 620 GLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNP 679 L+C V+S+PPARL + S S G +E+ Sbjct: 279 LRLVCAVNSNPPARLSWTRGSLTLCPSRSSNPGL--------------------LELPRV 318 Query: 680 LLEEEGLYLCEASNALGNASTSATFNGQ 707 + +EG + C A NA G+ S + + Q Sbjct: 319 HVRDEGEFTCRAQNAQGSQHISLSLSLQ 346 Score = 38.5 bits (88), Expect = 0.057 Identities = 37/131 (28%), Positives = 51/131 (38%), Gaps = 30/131 (22%) Query: 1511 CLAELP-TGAAASAPVMLRVLYPPKTPTMMVF--------VEPEGGLRGILD-------C 1554 C LP TG ++ V L V YPP TM VF G +L+ C Sbjct: 224 CQVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVC 283 Query: 1555 RVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICS 1614 V+S P A L+ GS + S+ S N +++ + D+GE+ C Sbjct: 284 AVNSNPPARLSWTRGSLTLCPSR--------------SSNPGLLELPRVHVRDEGEFTCR 329 Query: 1615 ASNVLGSASTS 1625 A N GS S Sbjct: 330 AQNAQGSQHIS 340 Score = 37.4 bits (85), Expect = 0.13 Identities = 64/277 (23%), Positives = 105/277 (37%), Gaps = 53/277 (19%) Query: 1222 NTLRLELRGPQPRDEGFY---------SCSARSPLGQANTSLELRLEGV--RVILAPEAA 1270 N L +R + RD+G Y S +S L L + + + R + Sbjct: 105 NDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGT 164 Query: 1271 VPEGAPITVTCADPAA---HAPTLYTWYHNGRWLQEGPAASLSFLVAT----RAHAGAYS 1323 + G +TC+ P A P + +W GP + S ++ + H + + Sbjct: 165 LESGHSRNLTCSVPWACKQGTPPMISWI-GASVSSPGPTTARSSVLTLTPKPQDHGTSLT 223 Query: 1324 CQAQ-DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV---------------IQC 1367 CQ G ++ L V Y P + ++ F+ S A+ + C Sbjct: 224 CQVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVC 283 Query: 1368 TVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTA 1427 V+S PPA L+ + L S +S G +++ R+ V+D + + C A Sbjct: 284 AVNSNPPARLSWTRGSLTLCPSR-----SSNPGLLELP----RVHVRD----EGEFTCRA 330 Query: 1428 QNLLGS--ISTIGRLQVEG---ARVVAEPGLDVPEGA 1459 QN GS IS LQ EG +R V++ L GA Sbjct: 331 QNAQGSQHISLSLSLQNEGTGTSRPVSQVTLAAVGGA 367 >gi|16506826 sialic acid binding immunoglobulin-like lectin-like protein 1 isoform b precursor [Homo sapiens] Length = 477 Score = 95.5 bits (236), Expect = 4e-19 Identities = 82/310 (26%), Positives = 135/310 (43%), Gaps = 33/310 (10%) Query: 26 PQDVQGVKGSCLLIPCIFSFPA-DVEVPDGITAIWYY---DYSGQRQVVSHSADPKLVEA 81 P+ V +G C+ +PC +P + + W+ D V +++ K+ E Sbjct: 38 PESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQED 97 Query: 82 RFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTL-VTVTEEPR 140 GR +G+P+ C+L ++D + DSG Y F+ E +W+ + L V VT Sbjct: 98 T-HGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGS-RKWNYIYDKLSVHVTALTH 155 Query: 141 VPTIASPVELLEGTEVDFNCSTPYVCLQ-EQVRLQWQGQDPARSVTFNSQKFEPTGVGHL 199 +PT + P L G + CS P+ C Q + W G + +PT + Sbjct: 156 MPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGA--------SVSSLDPT-ITRS 206 Query: 200 ETLHMAMSWQDHGRILRCQLSV--ANHRAQSEIHLQVKYAPKGVKI------------LL 245 L + QDHG L CQ+++ A + L + Y P+ + + L Sbjct: 207 SMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLR 266 Query: 246 SPSGRNILPGELVTLTCQVNSSYPAVSSIKW--LKDGVRLQTKTGVLHLPQAAWSDAGVY 303 + S ++L G+ + L C V+S+ PA S W L + GVL LP+ D G + Sbjct: 267 NGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEF 326 Query: 304 TCQAENGVGS 313 TC+A+N +GS Sbjct: 327 TCRAQNPLGS 336 Score = 68.9 bits (167), Expect = 4e-11 Identities = 71/245 (28%), Positives = 99/245 (40%), Gaps = 42/245 (17%) Query: 1048 NTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVW--------PGATVRE 1099 N L I A D G Y + G + +D +V+V PG T+ Sbjct: 111 NNCSLSIRDARKGDSGKYYFQVER--GSRKWNYIYDKLSVHVTALTHMPTFSIPG-TLES 167 Query: 1100 GQLVNLTCLV-WTTHPAQL-TYTWYQDGQQRLDA--------HSIPLPNVTVRDATSYRC 1149 G NLTC V W T TW LD IP P TS C Sbjct: 168 GHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQ---DHGTSLTC 224 Query: 1150 GVGPPGRAPRLSRPITLDVLYAPRNLRLTYL---------------LESHGGQLALVLCT 1194 V PG ++R + L++ Y P+NL +T L GQ ++C Sbjct: 225 QVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCA 284 Query: 1195 VDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSL 1254 VDS PPA+L+ + L+ S ++ N LEL +DEG ++C A++PLG + SL Sbjct: 285 VDSNPPARLSWTWGSLTLSPSQSS---NLGVLELPRVHVKDEGEFTCRAQNPLGSQHISL 341 Query: 1255 ELRLE 1259 L L+ Sbjct: 342 SLSLQ 346 Score = 63.2 bits (152), Expect = 2e-09 Identities = 69/272 (25%), Positives = 98/272 (36%), Gaps = 49/272 (18%) Query: 843 QVPSHGRFQ--AKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV 900 Q +HGRF + N+ L +R+ GDSG Y + GS + + V Sbjct: 95 QEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVER--GSRKWNYIYDKLSVHVTA 152 Query: 901 -------SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLT 953 S L+ G L+C V +GT G + R + ++L Sbjct: 153 LTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLI 212 Query: 954 QAGAYH-----CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL------ 1002 H CQ PG+ T A + L++SY P+++T+T G L Sbjct: 213 PQPQDHGTSLTCQVTLPGAGVTMTRA-VRLNISYPPQNLTMTVFQGDGTASTTLRNGSAL 271 Query: 1003 ---------LLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLE 1053 L+C VDS+PPA+L G L S Q PR+HV Sbjct: 272 SVLEGQSLHLVCAVDSNPPARLSWTWGS-LTLSPSQSSNLGVLELPRVHV---------- 320 Query: 1054 IHGAMLEDEGVYICEASNTLGQASASADFDAQ 1085 +DEG + C A N LG S Q Sbjct: 321 ------KDEGEFTCRAQNPLGSQHISLSLSLQ 346 Score = 53.1 bits (126), Expect = 2e-06 Identities = 48/200 (24%), Positives = 79/200 (39%), Gaps = 34/200 (17%) Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPL---ETVTLLPVARTDAALYA 773 TL+ G NLTC+V G+P +W V + ++L+P + Sbjct: 164 TLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLT 223 Query: 774 CRI-LTEAGAQLSTPVLLSVLYPPDRPKLSAL---------------LDMGQGHMALFIC 817 C++ L AG ++ V L++ YPP ++ L + +G +C Sbjct: 224 CQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVC 283 Query: 818 TVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCE 877 VDS P A L+ G L+ S +N LE+ + + D G + C Sbjct: 284 AVDSNPPARLSWTWGSLTLSPS--------------QSSNLGVLELPRVHVKDEGEFTCR 329 Query: 878 ATNVLGSSNTSLFFQVRGAW 897 A N LGS + SL ++ + Sbjct: 330 AQNPLGSQHISLSLSLQNEY 349 Score = 43.9 bits (102), Expect = 0.001 Identities = 40/133 (30%), Positives = 51/133 (38%), Gaps = 34/133 (25%) Query: 1511 CLAELP-TGAAASAPVMLRVLYPPKTPTMMVFVEP--------EGGLRGILD-------C 1554 C LP G + V L + YPP+ TM VF G +L+ C Sbjct: 224 CQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVC 283 Query: 1555 RVDSEPLASLTLHLGSRLVASSQPQ--GAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612 VDS P A L+ GS ++ SQ G P +HV D+GE+ Sbjct: 284 AVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHV----------------KDEGEFT 327 Query: 1613 CSASNVLGSASTS 1625 C A N LGS S Sbjct: 328 CRAQNPLGSQHIS 340 Score = 41.2 bits (95), Expect = 0.009 Identities = 54/239 (22%), Positives = 90/239 (37%), Gaps = 40/239 (16%) Query: 1222 NTLRLELRGPQPRDEGFYSCSARSPLGQANTSLE-LRLEGVRVILAPEAAVP----EGAP 1276 N L +R + D G Y + N + L + + P ++P G P Sbjct: 111 NNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHP 170 Query: 1277 ITVTCADPAA---HAPTLYTWYHNGRWLQEGP---AASLSFLVATRAHAGAYSCQAQ-DA 1329 +TC+ P A P TW + ++ LS + + H + +CQ Sbjct: 171 RNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPG 230 Query: 1330 QGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV---------------IQCTVDSEPP 1374 G +R L + Y PQ+ ++ F+ S + + C VDS PP Sbjct: 231 AGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPP 290 Query: 1375 AELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGS 1433 A L+ + L+ S +S G +++ R+ V+D + + C AQN LGS Sbjct: 291 ARLSWTWGSLTLSPSQ-----SSNLGVLELP----RVHVKD----EGEFTCRAQNPLGS 336 Score = 37.4 bits (85), Expect = 0.13 Identities = 63/266 (23%), Positives = 98/266 (36%), Gaps = 50/266 (18%) Query: 467 GTSGPNSLRLEIRDLEETDSGEYKCSA---TNSLGNATSTLDFHANAARLL--ISPAAEV 521 G N+ L IRD + DSG+Y + L H A + S + Sbjct: 106 GDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTL 165 Query: 522 VEGQ------AVTLSCRSGLSPTPDARFSWYLNGALLHEGPG---SSLLLPAASSTDAG- 571 G +V +C G PT +W + ++ P SS+L D G Sbjct: 166 ESGHPRNLTCSVPWACEQGTPPT----ITW-MGASVSSLDPTITRSSMLSLIPQPQDHGT 220 Query: 572 SYHCRARDGHSASGPSSPAVLTVLYPPRQPTFT----------TRLDLDAAGAGAGRRGL 621 S C+ + + L + YPP+ T T T + A G+ Sbjct: 221 SLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLH 280 Query: 622 LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLL 681 L+C VDS+PPARL T G S + +++ NL +E+ + Sbjct: 281 LVCAVDSNPPARLSW------------------TWG--SLTLSPSQSSNLGVLELPRVHV 320 Query: 682 EEEGLYLCEASNALGNASTSATFNGQ 707 ++EG + C A N LG+ S + + Q Sbjct: 321 KDEGEFTCRAQNPLGSQHISLSLSLQ 346 >gi|16506828 sialic acid binding immunoglobulin-like lectin-like protein 1 isoform a precursor [Homo sapiens] Length = 595 Score = 95.5 bits (236), Expect = 4e-19 Identities = 82/310 (26%), Positives = 135/310 (43%), Gaps = 33/310 (10%) Query: 26 PQDVQGVKGSCLLIPCIFSFPA-DVEVPDGITAIWYY---DYSGQRQVVSHSADPKLVEA 81 P+ V +G C+ +PC +P + + W+ D V +++ K+ E Sbjct: 156 PESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQED 215 Query: 82 RFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTL-VTVTEEPR 140 GR +G+P+ C+L ++D + DSG Y F+ E +W+ + L V VT Sbjct: 216 T-HGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGS-RKWNYIYDKLSVHVTALTH 273 Query: 141 VPTIASPVELLEGTEVDFNCSTPYVCLQ-EQVRLQWQGQDPARSVTFNSQKFEPTGVGHL 199 +PT + P L G + CS P+ C Q + W G + +PT + Sbjct: 274 MPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGA--------SVSSLDPT-ITRS 324 Query: 200 ETLHMAMSWQDHGRILRCQLSV--ANHRAQSEIHLQVKYAPKGVKI------------LL 245 L + QDHG L CQ+++ A + L + Y P+ + + L Sbjct: 325 SMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLR 384 Query: 246 SPSGRNILPGELVTLTCQVNSSYPAVSSIKW--LKDGVRLQTKTGVLHLPQAAWSDAGVY 303 + S ++L G+ + L C V+S+ PA S W L + GVL LP+ D G + Sbjct: 385 NGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEF 444 Query: 304 TCQAENGVGS 313 TC+A+N +GS Sbjct: 445 TCRAQNPLGS 454 Score = 68.9 bits (167), Expect = 4e-11 Identities = 71/245 (28%), Positives = 99/245 (40%), Gaps = 42/245 (17%) Query: 1048 NTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVW--------PGATVRE 1099 N L I A D G Y + G + +D +V+V PG T+ Sbjct: 229 NNCSLSIRDARKGDSGKYYFQVER--GSRKWNYIYDKLSVHVTALTHMPTFSIPG-TLES 285 Query: 1100 GQLVNLTCLV-WTTHPAQL-TYTWYQDGQQRLDA--------HSIPLPNVTVRDATSYRC 1149 G NLTC V W T TW LD IP P TS C Sbjct: 286 GHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQ---DHGTSLTC 342 Query: 1150 GVGPPGRAPRLSRPITLDVLYAPRNLRLTYL---------------LESHGGQLALVLCT 1194 V PG ++R + L++ Y P+NL +T L GQ ++C Sbjct: 343 QVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCA 402 Query: 1195 VDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSL 1254 VDS PPA+L+ + L+ S ++ N LEL +DEG ++C A++PLG + SL Sbjct: 403 VDSNPPARLSWTWGSLTLSPSQSS---NLGVLELPRVHVKDEGEFTCRAQNPLGSQHISL 459 Query: 1255 ELRLE 1259 L L+ Sbjct: 460 SLSLQ 464 Score = 63.2 bits (152), Expect = 2e-09 Identities = 69/272 (25%), Positives = 98/272 (36%), Gaps = 49/272 (18%) Query: 843 QVPSHGRFQ--AKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV 900 Q +HGRF + N+ L +R+ GDSG Y + GS + + V Sbjct: 213 QEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVER--GSRKWNYIYDKLSVHVTA 270 Query: 901 -------SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLT 953 S L+ G L+C V +GT G + R + ++L Sbjct: 271 LTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLI 330 Query: 954 QAGAYH-----CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL------ 1002 H CQ PG+ T A + L++SY P+++T+T G L Sbjct: 331 PQPQDHGTSLTCQVTLPGAGVTMTRA-VRLNISYPPQNLTMTVFQGDGTASTTLRNGSAL 389 Query: 1003 ---------LLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLE 1053 L+C VDS+PPA+L G L S Q PR+HV Sbjct: 390 SVLEGQSLHLVCAVDSNPPARLSWTWGS-LTLSPSQSSNLGVLELPRVHV---------- 438 Query: 1054 IHGAMLEDEGVYICEASNTLGQASASADFDAQ 1085 +DEG + C A N LG S Q Sbjct: 439 ------KDEGEFTCRAQNPLGSQHISLSLSLQ 464 Score = 57.4 bits (137), Expect = 1e-07 Identities = 95/447 (21%), Positives = 168/447 (37%), Gaps = 77/447 (17%) Query: 18 QASWGVSSPQDVQGVKGSCLLIPCIFSFPADV-EVPDGITAIWYY--DYSGQRQVVSHSA 74 Q + ++ + V +G C+ + C FS+P + D + W+ D+ + V+ + Sbjct: 21 QKDYLLTMQKSVTVQEGLCVSVLCSFSYPQNGWTASDPVHGYWFRAGDHVSRNIPVATNN 80 Query: 75 DPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWS---DVKGT 131 + V+ R R +G+P+++ C L ++D + D+G+Y F E + +W+ D Sbjct: 81 PARAVQEETRDRFHLLGDPQNKDCTLSIRDTRESDAGTYVFCVERGNM-KWNYKYDQLSV 139 Query: 132 LVTVTEEPRVP---TIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNS 188 VT +++ + V + EG V CS Y W P F Sbjct: 140 NVTASQDLLSRYRLEVPESVTVQEGLCVSVPCSVLY------PHYNWTASSPVYGSWFKE 193 Query: 189 QKFEPTGVGHLETLHMAMSWQD-HGRIL--------RCQLSVANHRA--QSEIHLQVKYA 237 P + +D HGR L C LS+ + R + + QV+ Sbjct: 194 GADIPWDIPVATNTPSGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERG 253 Query: 238 PKGVKILLSPSGRNI----------LPGELVT-----LTCQV--NSSYPAVSSIKWLKDG 280 + + ++ +PG L + LTC V +I W+ Sbjct: 254 SRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGAS 313 Query: 281 VR----LQTKTGVLHLPQAAWSDAGVYTCQAE-NGVG---------SLVSPP--ISLHIF 324 V T++ +L L TCQ G G ++ PP +++ +F Sbjct: 314 VSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVF 373 Query: 325 MAEVQVS------PAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTL--- 375 + S A +LE Q++ LVC + P+ L ++W + L + S L Sbjct: 374 QGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTW--GSLTLSPSQSSNLGVL 431 Query: 376 ---RLHLATRADTGFYFCEVQNVHGSE 399 R+H+ D G + C QN GS+ Sbjct: 432 ELPRVHV---KDEGEFTCRAQNPLGSQ 455 Score = 53.1 bits (126), Expect = 2e-06 Identities = 48/200 (24%), Positives = 79/200 (39%), Gaps = 34/200 (17%) Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPL---ETVTLLPVARTDAALYA 773 TL+ G NLTC+V G+P +W V + ++L+P + Sbjct: 282 TLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLT 341 Query: 774 CRI-LTEAGAQLSTPVLLSVLYPPDRPKLSAL---------------LDMGQGHMALFIC 817 C++ L AG ++ V L++ YPP ++ L + +G +C Sbjct: 342 CQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVC 401 Query: 818 TVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCE 877 VDS P A L+ G L+ S +N LE+ + + D G + C Sbjct: 402 AVDSNPPARLSWTWGSLTLSPS--------------QSSNLGVLELPRVHVKDEGEFTCR 447 Query: 878 ATNVLGSSNTSLFFQVRGAW 897 A N LGS + SL ++ + Sbjct: 448 AQNPLGSQHISLSLSLQNEY 467 Score = 43.9 bits (102), Expect = 0.001 Identities = 40/133 (30%), Positives = 51/133 (38%), Gaps = 34/133 (25%) Query: 1511 CLAELP-TGAAASAPVMLRVLYPPKTPTMMVFVEP--------EGGLRGILD-------C 1554 C LP G + V L + YPP+ TM VF G +L+ C Sbjct: 342 CQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVC 401 Query: 1555 RVDSEPLASLTLHLGSRLVASSQPQ--GAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612 VDS P A L+ GS ++ SQ G P +HV D+GE+ Sbjct: 402 AVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHV----------------KDEGEFT 445 Query: 1613 CSASNVLGSASTS 1625 C A N LGS S Sbjct: 446 CRAQNPLGSQHIS 458 Score = 41.2 bits (95), Expect = 0.009 Identities = 54/239 (22%), Positives = 90/239 (37%), Gaps = 40/239 (16%) Query: 1222 NTLRLELRGPQPRDEGFYSCSARSPLGQANTSLE-LRLEGVRVILAPEAAVP----EGAP 1276 N L +R + D G Y + N + L + + P ++P G P Sbjct: 229 NNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHP 288 Query: 1277 ITVTCADPAA---HAPTLYTWYHNGRWLQEGP---AASLSFLVATRAHAGAYSCQAQ-DA 1329 +TC+ P A P TW + ++ LS + + H + +CQ Sbjct: 289 RNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPG 348 Query: 1330 QGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV---------------IQCTVDSEPP 1374 G +R L + Y PQ+ ++ F+ S + + C VDS PP Sbjct: 349 AGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPP 408 Query: 1375 AELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGS 1433 A L+ + L+ S +S G +++ R+ V+D + + C AQN LGS Sbjct: 409 ARLSWTWGSLTLSPSQ-----SSNLGVLELP----RVHVKD----EGEFTCRAQNPLGS 454 Score = 37.4 bits (85), Expect = 0.13 Identities = 63/266 (23%), Positives = 98/266 (36%), Gaps = 50/266 (18%) Query: 467 GTSGPNSLRLEIRDLEETDSGEYKCSA---TNSLGNATSTLDFHANAARLL--ISPAAEV 521 G N+ L IRD + DSG+Y + L H A + S + Sbjct: 224 GDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTL 283 Query: 522 VEGQ------AVTLSCRSGLSPTPDARFSWYLNGALLHEGPG---SSLLLPAASSTDAG- 571 G +V +C G PT +W + ++ P SS+L D G Sbjct: 284 ESGHPRNLTCSVPWACEQGTPPT----ITW-MGASVSSLDPTITRSSMLSLIPQPQDHGT 338 Query: 572 SYHCRARDGHSASGPSSPAVLTVLYPPRQPTFT----------TRLDLDAAGAGAGRRGL 621 S C+ + + L + YPP+ T T T + A G+ Sbjct: 339 SLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLH 398 Query: 622 LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLL 681 L+C VDS+PPARL T G S + +++ NL +E+ + Sbjct: 399 LVCAVDSNPPARLSW------------------TWG--SLTLSPSQSSNLGVLELPRVHV 438 Query: 682 EEEGLYLCEASNALGNASTSATFNGQ 707 ++EG + C A N LG+ S + + Q Sbjct: 439 KDEGEFTCRAQNPLGSQHISLSLSLQ 464 >gi|157694526 Fc receptor-like 5 [Homo sapiens] Length = 977 Score = 92.8 bits (229), Expect = 3e-18 Identities = 199/821 (24%), Positives = 288/821 (35%), Gaps = 126/821 (15%) Query: 200 ETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVT 259 ET + Q+ G RCQ S +HL A L+ + ++ G+ V Sbjct: 69 ETPDNILEVQESGEY-RCQAQ--GSPLSSPVHLDFSSAS-----LILQAPLSVFEGDSVV 120 Query: 260 LTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPI 319 L C+ + ++I + + K H+P A D G Y C P+ Sbjct: 121 LRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKE----SCCPV 176 Query: 320 SLHIFMAEVQVSPAGPIL--------ENQTVTLVCNTP---NEAPSDLRYSWYKNHVLLE 368 S + +VQ P+L VTL C T + LR+ ++++ L Sbjct: 177 SSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLG 236 Query: 369 DAHSHTLRLHLAT--RADTGFYFCEVQNVHGSERS-GPVS-VVVNHPPLTPVLTAFLETQ 424 S + + D+GFY+C+ + S S P S + V P PVLT E Sbjct: 237 LGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKA 296 Query: 425 AGLVG---ILHCSVVSEPLATLV-LSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRD 480 G LHC + L TL H G L S + G S SL E Sbjct: 297 LNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCER-----GASISFSLTTE--- 348 Query: 481 LEETDSGEYKCSATNSLGNATS---TLDFHANAARLLI---SPAAEVVEGQAVTLSCRSG 534 +SG Y C+A N LG S +L + ++ SP + EG VTL C + Sbjct: 349 ----NSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQ 404 Query: 535 LSPTPDARFSWYLNGALLH----EGPGSSLLLPAASSTDAGSYHCRARDGHSASGP--SS 588 P + ++ GA L G + + ++ +G+Y+C A +G GP S Sbjct: 405 RGSLP-ILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGF---GPQRSK 460 Query: 589 PAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARL-QLLHKDRVVATSL 647 L+V P P T L A G L C V P L Q H+D + +S Sbjct: 461 AVSLSVTVPVSHPVLT--LSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSS- 517 Query: 648 PSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLE-EEGLYLCEASNALGNASTSATFNG 706 P++ RV L E G Y C A N G S + Sbjct: 518 -------------------STPSVGRVSFSFSLTEGHSGNYYCTADNGFG-PQRSEVVSL 557 Query: 707 QATVLAIAPSHTLQ-------EGTEANLTCNVSREAAGSPANFSWFRN-----GVLWAQG 754 TV P TL+ G L C R GSP WF + G A Sbjct: 558 FVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPR---GSPPILYWFYHEDVTLGSSSAPS 614 Query: 755 PLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQ---GH 811 E L + + Y+C AQ S + LSV+ P RP L+ Q G Sbjct: 615 GGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGD 674 Query: 812 MALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDS 871 + C +L F+ E + + PS G + +L L S Sbjct: 675 LLELHCEALRGSSPILYWFYHEDVTLGKI--SAPSGG-----GASFNLSLTTEH-----S 722 Query: 872 GSYRCEATNVLGSSNTSLFF------QVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEG 925 G Y CEA N L + + + R +P G + L C+ G P Sbjct: 723 GIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPL- 781 Query: 926 TSYRWYRD----GQPLQESTSATLRFAAITLTQAGAYHCQA 962 YR++ + G S A+L ++T +G Y C+A Sbjct: 782 ILYRFFHEDVTLGNRSSPSGGASLNL-SLTAEHSGNYSCEA 821 Score = 92.0 bits (227), Expect = 4e-18 Identities = 162/685 (23%), Positives = 251/685 (36%), Gaps = 95/685 (13%) Query: 99 NLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIA-SPVELL--EGTE 155 N + + +DSG Y + + SD + + V P + SP + L EGT+ Sbjct: 244 NFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTK 303 Query: 156 VDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRIL 215 V +C T L+ R +G P R + ++ ++ +++ ++ G Sbjct: 304 VTLHCETQEDSLRTLYRFYHEGV-PLRHKSVRCERGA--------SISFSLTTENSGNYY 354 Query: 216 RCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVN-SSYPAVSSI 274 + + + L V + LS I G VTL C+ S P + Sbjct: 355 CTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPIL--Y 412 Query: 275 KWLKDGVRLQTKT-----GVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQ 329 ++ +G L+ ++ GV +G Y C A+NG G S +SL V Sbjct: 413 QFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSL-----SVT 467 Query: 330 VSPAGPIL----------ENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHL 379 V + P+L E TVTL C +P L ++++ L + R+ Sbjct: 468 VPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSF 527 Query: 380 A---TRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVG---ILHC 433 + T +G Y+C N G +RS VS+ V P P+LT + +VG LHC Sbjct: 528 SFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHC 587 Query: 434 SVV-SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCS 492 P H L S+S S F+ L SG Y C Sbjct: 588 EAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFN------------LSLTAEHSGNYSCE 635 Query: 493 ATNSL---GNATSTLDFHANAARLLI---SPAAEVVEGQAVTLSCRSGLSPTPDARFSWY 546 A N L + T +L +R ++ +P A+ V G + L C + +P + ++ Sbjct: 636 ANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYH 695 Query: 547 ----LNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPT 602 L G G+S L + ++ +G Y C A +G A S L V P +P Sbjct: 696 EDVTLGKISAPSGGGASFNL-SLTTEHSGIYSCEADNGLEAQ-RSEMVTLKVAVPVSRPV 753 Query: 603 FTTRLDLDAAGAGAGRRGLLLCRVDS---DPPARLQLLHKDRVVATSLPSGGGCSTCGGC 659 T R A G A LL ++ P + H+D + G S GG Sbjct: 754 LTLR----APGTHAAVGDLLELHCEALRGSPLILYRFFHED------VTLGNRSSPSGGA 803 Query: 660 SPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTL 719 S + +T E G Y CEA N LG A S T T L S Sbjct: 804 SLNLSLT--------------AEHSGNYSCEADNGLG-AQRSETVTLYITGLTANRSGPF 848 Query: 720 QEGTEANLTCNVSREAAGSPANFSW 744 G L +++ AAG+ + W Sbjct: 849 ATGVAGGL-LSIAGLAAGALLLYCW 872 Score = 85.9 bits (211), Expect = 3e-16 Identities = 216/888 (24%), Positives = 310/888 (34%), Gaps = 142/888 (15%) Query: 243 ILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW----LKDGVRLQTKTGVLHLPQAAWS 298 I L P + GE VTLTC+ Y + KW L + +T +L + Sbjct: 25 IFLQPPWTTVFQGERVTLTCKGFRFY-SPQKTKWYHRYLGKEILRETPDNILEV-----Q 78 Query: 299 DAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRY 358 ++G Y CQA+ GS +S P+ L A + + + E +V L C +A L Sbjct: 79 ESGEYRCQAQ---GSPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRA--KAEVTLNN 133 Query: 359 SWYKNHVLLEDAHSHT-LRLHLATRADTGFYFCE-VQNVHGSERSGPVSVVVNHPPLTPV 416 + YKN +L + T + A D G Y C + S V + V P PV Sbjct: 134 TIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPV 193 Query: 417 LTA-FLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLR 475 L A + +G L C L L L D + + PN Sbjct: 194 LRASSFQPISGNPVTLTCE------TQLSLERSDVPLRFRFFRDDQTLGLGWSLSPN--- 244 Query: 476 LEIRDLEETDSGEYKCSATNSLGNATS-------TLDFHANAARLLISPAAEV-VEGQAV 527 +I + DSG Y C A + S + A+ L +SP + EG V Sbjct: 245 FQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKV 304 Query: 528 TLSCRSGLSPTPDARFSWYLNGA-LLHEG----PGSSLLLPAASSTDAGSYHCRARDGHS 582 TL C + + + +Y G L H+ G+S+ + ++ ++G+Y+C A +G Sbjct: 305 TLHCET-QEDSLRTLYRFYHEGVPLRHKSVRCERGASISF-SLTTENSGNYYCTADNGLG 362 Query: 583 ASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVD-SDPPARLQLLHKDR 641 A PS L+V P P D GA + L C P Q H+ Sbjct: 363 AK-PSKAVSLSVTVPVSHPVLNLSSPEDLIFEGA--KVTLHCEAQRGSLPILYQFHHEGA 419 Query: 642 VVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG----- 696 + ++ GG + +T E G Y C A N G Sbjct: 420 ALERR-----SANSAGGVAISFSLT--------------AEHSGNYYCTADNGFGPQRSK 460 Query: 697 NASTSATFNGQATVLAIAPSHTLQ-EGTEANLTCNVSREAAGSPANFSWF--RNGVLWAQ 753 S S T VL ++ + L EG L C V R GSP F + LW+ Sbjct: 461 AVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQR---GSPQILYQFYHEDMPLWSS 517 Query: 754 GPLETVTL---LPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQ- 809 + + + Y C G Q S V L V P RP L+ + Q Sbjct: 518 STPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQA 577 Query: 810 --GHMALFICTVD-SRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEAN-SLKLEVRE 865 G + C P L +H + L +S PS G +A N SL E Sbjct: 578 VVGDLLELHCEAPRGSPPILYWFYHEDVTLGSS---SAPSGG----EASFNLSLTAE--- 627 Query: 866 LGLGDSGSYRCEATNVL---GSSNTSLFFQV---RGAWVQVSPSPELQEGQAVVLSCQVH 919 SG+Y CEA N L S SL V R +P + G + L C+ Sbjct: 628 ----HSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEAL 683 Query: 920 TGVPEGTSYRWYRD---GQPLQESTSATLRFAAITLTQAGAYHC------QAQAPGSATT 970 G + ++ D G+ S ++T +G Y C +AQ T Sbjct: 684 RGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTL 743 Query: 971 SLAAPIS---LHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQL-RLLHGDRLVAS 1026 +A P+S L + H + L++ L C P L R H D Sbjct: 744 KVAVPVSRPVLTLRAPGTHAAVGDLLE--------LHCEALRGSPLILYRFFHED----V 791 Query: 1027 TLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLG 1074 TL P G + +L L + E G Y CEA N LG Sbjct: 792 TLGNRSSPSGGA----------SLNLSL---TAEHSGNYSCEADNGLG 826 Score = 80.9 bits (198), Expect = 1e-14 Identities = 178/698 (25%), Positives = 246/698 (35%), Gaps = 114/698 (16%) Query: 244 LLSPSGRNILPGELVTLTCQVNSSYPAVS---SIKWLKDGVRLQTKTGVLHLPQ--AAWS 298 +L S + G VTLTC+ S ++ +D L + Q A WS Sbjct: 193 VLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWS 252 Query: 299 -DAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPIL----------ENQTVTLVCN 347 D+G Y C+A S++S I +VQ+ + P+L E VTL C Sbjct: 253 KDSGFYWCKAATMPYSVISDSPRSWI---QVQIPASHPVLTLSPEKALNFEGTKVTLHCE 309 Query: 348 TPNEAPSDLRYSWYKNHVLLEDAHSHTLR----LHLATRADTGFYFCEVQNVHGSERSGP 403 T ++ L Y +Y V L R T ++G Y+C N G++ S Sbjct: 310 TQEDSLRTL-YRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKA 368 Query: 404 VSVVVNHPPLTPVLTAFLETQAGLVGI---LHCSVVSEPLATLV-LSHGGHILASTSGDS 459 VS+ V P PVL G LHC L L H G L S +S Sbjct: 369 VSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANS 428 Query: 460 DHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATS-----TLDFHANAARLL 514 G + SL E SG Y C+A N G S ++ + L Sbjct: 429 A-----GGVAISFSLTAE-------HSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLT 476 Query: 515 ISPA-AEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEG--PGSSLLLPAASSTD-- 569 +S A A EG VTL C +P + +Y L P + + S T+ Sbjct: 477 LSSAEALTFEGATVTLHCEVQRG-SPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGH 535 Query: 570 AGSYHCRARDGHSASGPSSPAVLT--VLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVD 627 +G+Y+C A +G GP V++ V P +P T R+ A A G L C Sbjct: 536 SGNYYCTADNGF---GPQRSEVVSLFVTVPVSRPILTLRVP--RAQAVVGDLLELHCEAP 590 Query: 628 -SDPPARLQLLHKDRVV-ATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685 PP H+D + ++S PSGG S + +T E G Sbjct: 591 RGSPPILYWFYHEDVTLGSSSAPSGGEASF------NLSLTA--------------EHSG 630 Query: 686 LYLCEASNALGNASTSATFNGQATVLAIAPSHTLQE-------GTEANLTCNVSREAAGS 738 Y CEA+N L A S T + V P T + G L C R GS Sbjct: 631 NYSCEANNGLV-AQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALR---GS 686 Query: 739 PANFSWFRN-----GVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVL 793 WF + G + A L + + +Y+C AQ S V L V Sbjct: 687 SPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVA 746 Query: 794 YPPDRPKLSALLD---MGQGHMALFIC-TVDSRPLALLALFHGEHLLATSLGPQVPSHGR 849 P RP L+ G + C + PL L FH + L P + Sbjct: 747 VPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPSGGASLN 806 Query: 850 FQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNT 887 AE SG+Y CEA N LG+ + Sbjct: 807 LSLTAE--------------HSGNYSCEADNGLGAQRS 830 Score = 74.7 bits (182), Expect = 7e-13 Identities = 206/884 (23%), Positives = 314/884 (35%), Gaps = 162/884 (18%) Query: 866 LGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEG 925 L + +SG YRC+A SS L F +Q S + EG +VVL C+ V Sbjct: 75 LEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLS--VFEGDSVVLRCRAKAEVTLN 132 Query: 926 TSYRWYRDGQPLQESTSAT-LRFAAITLTQAGAYHC----QAQAPGSATT-------SLA 973 + Y++ L T L GAY C ++ P S+ T Sbjct: 133 NTI--YKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFT 190 Query: 974 APISLHVSYAP---RHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQG 1030 P+ S+ P VTLT R SD P + R D+ + G Sbjct: 191 RPVLRASSFQPISGNPVTLTCETQLSLER---------SDVPLRFRFFRDDQTL-----G 236 Query: 1031 VGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQ 1090 +G +++PN +I +D G Y C+A+ S +D + VQ Sbjct: 237 LGW----------SLSPN---FQITAMWSKDSGFYWCKAATM--PYSVISDSPRSWIQVQ 281 Query: 1091 V---WPGATVREGQLVNLTCLVWTTH------PAQLTYTWYQDG------QQRLDAHSIP 1135 + P T+ + +N T H + Y +Y +G R + + Sbjct: 282 IPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASI 341 Query: 1136 LPNVTVRDATSYRC----GVGP-PGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLAL 1190 ++T ++ +Y C G+G P +A LS +T+ V + NL L G ++ L Sbjct: 342 SFSLTTENSGNYYCTADNGLGAKPSKAVSLS--VTVPVSHPVLNLSSPEDLIFEGAKVTL 399 Query: 1191 VLCTVDSRPPAQLALSHAGRLLASSTAASVPNT-LRLELRGPQPRDEGFYSCSARSPLG- 1248 P H G L +A S + L G Y C+A + G Sbjct: 400 HCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEH---SGNYYCTADNGFGP 456 Query: 1249 QANTSLELRL-----EGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGR--WL 1301 Q + ++ L + V + + EA EGA +T+ C LY +YH W Sbjct: 457 QRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWS 516 Query: 1302 QEGPAA---SLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSR 1358 P+ S SF + T H+G Y C A + G + S +L V P + + R R Sbjct: 517 SSTPSVGRVSFSFSL-TEGHSGNYYCTADNGFGPQRSEVVSLFVT-VPVSRPILTLRVPR 574 Query: 1359 ARSMA----VIQCTVD-SEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQV 1413 A+++ + C PP H+ L +SS SG + L + Sbjct: 575 AQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSA----PSG------GEASFNLSL 624 Query: 1414 QDVPAGDDTYVCTAQN-LLGSISTIGRLQV-----EGARVVAEPGLDVPEGAALNLSCRL 1467 +G+ Y C A N L+ S L V P G L L C Sbjct: 625 TAEHSGN--YSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEA 682 Query: 1468 LGGPGPVGNSTFAWFWNDR----RLHAEPVPTLAFT-HVARAQAGMYHCLAELPTGAAAS 1522 L G P+ WF+++ ++ A +F + +G+Y C A+ A S Sbjct: 683 LRGSSPI----LYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRS 738 Query: 1523 APVMLRVLYPPKTPTMMVFVEPEGGLRG-ILDCRVDSEPLASLTLH--------LGSRLV 1573 V L+V P P + + G +L+ ++ + L L+ LG+R Sbjct: 739 EMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNR-- 796 Query: 1574 ASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTST---YFGV 1630 S P G AS N +L G Y C A N LG+ + T Y Sbjct: 797 --SSPSGG---------ASLNL------SLTAEHSGNYSCEADNGLGAQRSETVTLYITG 839 Query: 1631 RALHRLHQFQQ-----LLWVLGLLVGLLLLLLGLGACYTWRRRR 1669 +R F LL + GL G LLL Y W R+ Sbjct: 840 LTANRSGPFATGVAGGLLSIAGLAAGALLL-------YCWLSRK 876 Score = 32.7 bits (73), Expect = 3.1 Identities = 29/121 (23%), Positives = 48/121 (39%), Gaps = 7/121 (5%) Query: 1267 PEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQA 1326 P V +G +T+TC ++P WYH R+L + + +G Y CQ Sbjct: 30 PWTTVFQGERVTLTCKGFRFYSPQKTKWYH--RYLGKEILRETPDNILEVQESGEYRCQ- 86 Query: 1327 QDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVL 1386 AQG+ S P L ++ +L + V++C +E + + VL Sbjct: 87 --AQGSPLSSPVHLD--FSSASLILQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVL 142 Query: 1387 A 1387 A Sbjct: 143 A 143 >gi|15147240 brother of CDO [Homo sapiens] Length = 1114 Score = 92.0 bits (227), Expect = 4e-18 Identities = 109/395 (27%), Positives = 166/395 (42%), Gaps = 60/395 (15%) Query: 898 VQVSPSPELQE-GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQES--------TSATLRFA 948 V V P+ +Q+ G V+L C V P + W +G+ L S T TL Sbjct: 38 VTVQPASTVQKPGGTVILGCVVE---PPRMNVTWRLNGKELNGSDDALGVLITHGTLVIT 94 Query: 949 AITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRV- 1007 A+ G Y C A+ P A S+ A ++L + + + +++ G ++ C + Sbjct: 95 ALNNHTVGRYQCVARMPAGAVASVPATVTL-ANLQDFKLDVQHVIEVDEGNTAVIACHLP 153 Query: 1008 DSDPPAQLRL-LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYI 1066 +S P AQ+R + + L AS + P G+ L+I A EDEG+Y Sbjct: 154 ESHPKAQVRYSVKQEWLEASRGNYLIMPSGN--------------LQIVNASQEDEGMYK 199 Query: 1067 CEASNTLGQ---ASASAD------FDAQAVNVQVWPGAT---VREGQLVNLTCLVWTTHP 1114 C A N + Q S S+D A+A + P A V +GQ + L C+ P Sbjct: 200 CAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPP 259 Query: 1115 AQLTYTWYQDGQQ-------RLDAHSIPLPNVTVRDATSYRC----GVGPPGRAPRLSRP 1163 ++T W +DG R ++ + + D+ +YRC GVG PG A L Sbjct: 260 PRVT--WAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVIL--- 314 Query: 1164 ITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQ-LALSHAGRLLASSTAASVPN 1222 + V P L GQ A + C V PP L L +A L++S Sbjct: 315 YNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRR 374 Query: 1223 TLRLELRGPQPRDEGFYSCSARSPLGQANTSLELR 1257 LR+ GP+ DEG Y C A + +G A+ ++LR Sbjct: 375 ALRVLSMGPE--DEGVYQCMAENEVGSAHAVVQLR 407 Score = 68.6 bits (166), Expect = 5e-11 Identities = 121/507 (23%), Positives = 201/507 (39%), Gaps = 69/507 (13%) Query: 1073 LGQASASADFDAQAVNVQVWPGATVRE-GQLVNLTCLVWTTHPAQLTYTWYQDGQQRL-- 1129 L A AD + + V V P +TV++ G V L C+V P ++ TW +G++ Sbjct: 23 LATAGCFADLN-EVPQVTVQPASTVQKPGGTVILGCVV---EPPRMNVTWRLNGKELNGS 78 Query: 1130 -DAHSIPLPNVTV-------RDATSYRCGVG-PPGRAPRLSRPITLDVLYAPRNLRLTYL 1180 DA + + + T+ Y+C P G + +TL L + L + ++ Sbjct: 79 DDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFK-LDVQHV 137 Query: 1181 LESHGGQLALVLCTV-DSRPPAQLALSHAGRLLASSTAAS-VPNTLRLELRGPQPRDEGF 1238 +E G A++ C + +S P AQ+ S L +S + + L++ DEG Sbjct: 138 IEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGM 197 Query: 1239 YSCSARSPLGQ----ANTSLELRL-----EGVRVILAPEAA---VPEGAPITVTCADPAA 1286 Y C+A +P+ Q + +S LR+ E R+I PEA V +G + + C Sbjct: 198 YKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGI 257 Query: 1287 HAPTLYTW---------YHNGRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRP 1337 P + TW Y+ R+L ++L + +G Y C A + G +P Sbjct: 258 PPPRV-TWAKDGSSVTGYNKTRFL----LSNLLIDTTSEEDSGTYRCMADNGVG----QP 308 Query: 1338 AALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLAS 1397 A +LY Q V + S VI ++ E+ + VL + V ++S Sbjct: 309 GAAVILYNVQ--VFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISS 366 Query: 1398 GTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPE 1457 ++++R ALR+ P + Y C A+N +GS + +L+ + D Sbjct: 367 Q--RLRLSRRALRVLSMG-PEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQD--- 420 Query: 1458 GAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPT 1517 L G PV S ++ L +P T V A C E Sbjct: 421 -------AELATGTPPVSPSKLG--NPEQMLRGQPALPRPPTSVGPASP---QCPGEKGQ 468 Query: 1518 GAAASAPVMLRVLYPPKTPTMMVFVEP 1544 GA A AP++L KT + + P Sbjct: 469 GAPAEAPIILSSPRTSKTDSYELVWRP 495 Score = 65.5 bits (158), Expect = 4e-10 Identities = 98/400 (24%), Positives = 157/400 (39%), Gaps = 64/400 (16%) Query: 327 EVQVSPAGPILE-NQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH--------TLRL 377 +V V PA + + TV L C P + +W N L + TL + Sbjct: 37 QVTVQPASTVQKPGGTVILGCVVE---PPRMNVTWRLNGKELNGSDDALGVLITHGTLVI 93 Query: 378 HLATRADTGFYFCEVQNVHGSERSGPVSVVV-NHPPLTPVLTAFLETQAGLVGILHCSVV 436 G Y C + G+ S P +V + N + +E G ++ C + Sbjct: 94 TALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLP 153 Query: 437 -SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATN 495 S P A + S L ++ G+ P S L+I + + D G YKC+A N Sbjct: 154 ESHPKAQVRYSVKQEWLEASRGNYLIMP---------SGNLQIVNASQEDEGMYKCAAYN 204 Query: 496 SLGNATSTLDFH---------ANAARLLISPAAE---VVEGQAVTLSCRSGLSPTPDARF 543 + T A AAR++ P A+ V +GQ++ L C + P P R Sbjct: 205 PVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPP--RV 262 Query: 544 SWYLNGALLHEGPG-----SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598 +W +G+ + S+LL+ S D+G+Y C A +G G + ++ P Sbjct: 263 TWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEP 322 Query: 599 RQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGG 658 + T ++L G+ L C V +PP + L A L S Sbjct: 323 PEVT----MELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRN----AVPLIS--------- 365 Query: 659 CSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNA 698 S R+++++ LRV P E+EG+Y C A N +G+A Sbjct: 366 -SQRLRLSR--RALRVLSMGP--EDEGVYQCMAENEVGSA 400 Score = 54.3 bits (129), Expect = 1e-06 Identities = 94/366 (25%), Positives = 145/366 (39%), Gaps = 68/366 (18%) Query: 1293 TWYHNGRWLQEGPAASLSFLV--------ATRAHA-GAYSCQAQDAQGTRSSRPAALQVL 1343 TW NG+ L G +L L+ A H G Y C A+ G +S PA + + Sbjct: 67 TWRLNGKELN-GSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTL- 124 Query: 1344 YAPQDAVLSSFR-------DSRARSMAVIQCTV-DSEPPAELALSHDGKVLATSSGVHSL 1395 A L F+ + + AVI C + +S P A++ S + L S G + L Sbjct: 125 -----ANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNY-L 178 Query: 1396 ASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQN-LLGSISTIG---RLQV-----EGAR 1446 +G++Q+ V + Y C A N + + T G RL+V E AR Sbjct: 179 IMPSGNLQI--------VNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAAR 230 Query: 1447 VVAEPGLD---VPEGAALNLSCRLLGGPGP-----VGNSTFAWFWNDRRLHAEPVPTLAF 1498 ++ P V +G +L L C G P P S+ + R L + L Sbjct: 231 IIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFL----LSNLLI 286 Query: 1499 THVARAQAGMYHCLAELPTGAAASAPVM--LRVLYPPKTPTMMVFVEPEGGLRGILDCRV 1556 + +G Y C+A+ G +A ++ ++V PP+ + + G L C V Sbjct: 287 DTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEV 346 Query: 1557 DSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSAS 1616 P S+ + + SSQ + S ALRV ++ P D+G Y C A Sbjct: 347 RGNPPPSVLWLRNAVPLISSQ----------RLRLSRRALRV--LSMGPEDEGVYQCMAE 394 Query: 1617 NVLGSA 1622 N +GSA Sbjct: 395 NEVGSA 400 Score = 43.1 bits (100), Expect = 0.002 Identities = 76/324 (23%), Positives = 127/324 (39%), Gaps = 42/324 (12%) Query: 49 VEVPDGITAI--WYYDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQ 106 +EV +G TA+ + S + V +S + +EA RG M + ++ N +D Sbjct: 138 IEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEAS-RGNYLIMPSGNLQIVNASQEDEG 196 Query: 107 PEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRV--PTIASPVELLEGTEVDFNCSTPY 164 +YN + + + SD + E R+ P A + + +G + C Sbjct: 197 MYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASG 256 Query: 165 VCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLS--VA 222 + R+ W +D + +N +F L L + + ++ RC V Sbjct: 257 I---PPPRVTW-AKDGSSVTGYNKTRFL------LSNLLIDTTSEEDSGTYRCMADNGVG 306 Query: 223 NHRAQSEIHLQVKYAPKGVKILLSPSGRNILP-GELVTLTCQVNSSYPAVSSIKWLKDGV 281 A ++ + P V + LS + ++P G+ LTC+V + P S+ WL++ V Sbjct: 307 QPGAAVILYNVQVFEPPEVTMELS---QLVIPWGQSAKLTCEVRGNPPP--SVLWLRNAV 361 Query: 282 ------RLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGP 335 RL+ L + D GVY C AEN VGS A VQ+ + P Sbjct: 362 PLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSA----------HAVVQLRTSRP 411 Query: 336 ILEN---QTVTLVCNTPNEAPSDL 356 + Q L TP +PS L Sbjct: 412 SITPRLWQDAELATGTPPVSPSKL 435 Score = 39.3 bits (90), Expect = 0.033 Identities = 91/417 (21%), Positives = 148/417 (35%), Gaps = 63/417 (15%) Query: 255 GELVTLTCQVNSSYPAVS---SIK--WLKD--GVRLQTKTGVLHLPQAAWSDAGVYTCQA 307 G + C + S+P S+K WL+ G L +G L + A+ D G+Y C A Sbjct: 143 GNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAA 202 Query: 308 ENGVGSLVSPPISLHIFMAEVQVSPAGPIL-----------ENQTVTLVCNTPNEAPSDL 356 N V V S + A I+ + Q++ L C P Sbjct: 203 YNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPP-- 260 Query: 357 RYSWYKNHVLLEDAHS-----HTLRLHLATRADTGFYFCEVQNVHGSERSGPV--SVVVN 409 R +W K+ + + L + + D+G Y C N G + + +V V Sbjct: 261 RVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVF 320 Query: 410 HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTS 469 PP + + L G L C V P +++ L S+ R S + Sbjct: 321 EPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQ-----RLRLSRRA 375 Query: 470 GPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA----AEVVEGQ 525 L + + D G Y+C A N +G+A + + +R I+P AE+ G Sbjct: 376 ------LRVLSMGPEDEGVYQCMAENEVGSAHAVVQL--RTSRPSITPRLWQDAELATGT 427 Query: 526 AVTLSCRSGLSPTPDARFSWYLNGALLHEGPGS---------------SLLLPAASSTDA 570 + G +P R L GP S ++L + ++ Sbjct: 428 PPVSPSKLG-NPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKT 486 Query: 571 GSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVD 627 SY R H SG + +L + R+ T ++ D +G A + L L R+D Sbjct: 487 DSYELVWRPRHEGSGRA--PILYYVVKHRKVTNSSD-DWTISGIPANQHRLTLTRLD 540 Score = 38.1 bits (87), Expect = 0.074 Identities = 92/429 (21%), Positives = 159/429 (37%), Gaps = 88/429 (20%) Query: 512 RLLISPAAEVVE-GQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGS--------SLLL 562 ++ + PA+ V + G V L C + P +W LNG L+ + +L++ Sbjct: 37 QVTVQPASTVQKPGGTVILGC---VVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVI 93 Query: 563 PAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLD-AAGAGAGRRGL 621 A ++ G Y C AR A S PA +T+ +LD+ G + Sbjct: 94 TALNNHTVGRYQCVARMPAGAVA-SVPATVTLANLQ-----DFKLDVQHVIEVDEGNTAV 147 Query: 622 LLCRV-DSDPPARLQLLHKDRVVATS------LPSGGGCSTCGGCSPRMKVTKAPNLLRV 674 + C + +S P A+++ K + S +PSG + Sbjct: 148 IACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGN----------------------L 185 Query: 675 EIHNPLLEEEGLYLCEASNAL-------GNASTSATFNGQATVLAI-----APSHTLQEG 722 +I N E+EG+Y C A N + G++ A I A + + +G Sbjct: 186 QIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKG 245 Query: 723 TEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLP------VARTDAALYACRI 776 L C S P +W ++G G +T LL + D+ Y C Sbjct: 246 QSLILECVAS---GIPPPRVTWAKDGSS-VTGYNKTRFLLSNLLIDTTSEEDSGTYRCMA 301 Query: 777 LTEAGAQLSTPVL--LSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPL-ALLALFHGE 833 G + +L + V PP+ + L + G A C V P ++L L + Sbjct: 302 DNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAV 361 Query: 834 HLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQV 893 L+++ + + L V +G D G Y+C A N +GS++ + Q+ Sbjct: 362 PLISSQ-------------RLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVV--QL 406 Query: 894 RGAWVQVSP 902 R + ++P Sbjct: 407 RTSRPSITP 415 >gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sapiens] Length = 2113 Score = 91.7 bits (226), Expect = 6e-18 Identities = 150/617 (24%), Positives = 234/617 (37%), Gaps = 86/617 (13%) Query: 903 SPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQ-----AGA 957 S E+ G V L C +G P + RW +DG+PL + T R +T++ +G Sbjct: 294 SQEVWAGHTVELPCTA-SGYPI-PAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSGT 351 Query: 958 YHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTL-MDTGPGRLGLLLCRVDSDPPAQLR 1016 Y C+ + T A + + P HVTLT + TG G +L C + P +R Sbjct: 352 YICEV----TNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIR 407 Query: 1017 LLHGDRLV----ASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNT 1072 LV A +++G+ L I A G Y C A+ Sbjct: 408 WYRNTELVLPDEAISIRGLSNET----------------LLITSAQKSHSGAYQCFATR- 450 Query: 1073 LGQASASADFDAQAVN------VQVWPGATVREGQLVNLTCLVWTTHPAQLTYTW----- 1121 +A + DF A+ V + V G+ +L C P +T+ Sbjct: 451 --KAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI 508 Query: 1122 YQDGQQRL------DAHSIPLPNVT---VRDATSYRCG----VGPPGRAPRLSRPITLDV 1168 +DG R D +I NVT +RD YRC VG R++ Sbjct: 509 VRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARIN------- 561 Query: 1169 LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLEL 1228 + P ++R + + G+ L+ C V P + LL + V L+L Sbjct: 562 VRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKL 621 Query: 1229 RGPQP-RDEGFYSCSAR-SPLGQANTSLELRLEGVRVILAPEAAVPE--GAPITVTCADP 1284 Q DEG Y CS P + S+ + ++ V ++ P P G + + C Sbjct: 622 TDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVK-VPPLIQPFEFPPASIGQLLYIPCVVS 680 Query: 1285 AAHAPTLYTWYHNGRWLQEGPA---------ASLSFLVATRAHAGAYSCQAQDAQGTRSS 1335 + P TW +G+ + G +SL + H G Y+C A +A T S Sbjct: 681 SGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAAT-VS 739 Query: 1336 RPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSL 1395 R L V P+ V + +D V+ C+VD PP ++ H K H + Sbjct: 740 RERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKH-AKGSGNPQQYHPV 798 Query: 1396 ASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGS-ISTIGRLQVE-GARVVAEPGL 1453 TG +Q+ N+ L + Y+C A N +G+ IS L V+ A + + P Sbjct: 799 PL-TGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNT 857 Query: 1454 DVP-EGAALNLSCRLLG 1469 + +G A L+C G Sbjct: 858 TIAIKGHAKELNCTARG 874 Score = 85.1 bits (209), Expect = 5e-16 Identities = 164/778 (21%), Positives = 283/778 (36%), Gaps = 105/778 (13%) Query: 303 YTCQAENGVGSLVSPPISLHIFMAE---VQVSPAGPILENQTVTLVCNTPNEAPSDLRY- 358 Y C AEN G + SP I + E V+V + N V C P+ + Sbjct: 161 YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAV-FKCLIPSSVQEYVSVV 219 Query: 359 SWYKNHVLLEDAHSHTLRLH-------LATRADTGFYFCEVQNVHGSE--RSGPVSVVVN 409 SW K+ V + H + H + Y C ++ + E +S + V Sbjct: 220 SWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVT 279 Query: 410 HPP--LTPVLTAF--LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRF 465 P + +L F E AG L C+ P+ + G L + DS + R Sbjct: 280 DPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPA---DSRWTKRI 336 Query: 466 SGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATST-LDFHANAARLLISP-AAEVVE 523 +G L I DL DSG Y C TN+ G+A +T + + + ++P + Sbjct: 337 TG--------LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGI 388 Query: 524 GQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSS--------LLLPAASSTDAGSYHC 575 G V LSC L+ +P+ WY N L+ S LL+ +A + +G+Y C Sbjct: 389 GSTVILSC--ALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQC 446 Query: 576 RARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635 A + + L P +F+ ++ G + L+C PP + Sbjct: 447 FATRKAQTAQDFAIIALEDGTPRIVSSFSEKV------VNPGEQFSLMCAAKGAPPPTVT 500 Query: 636 LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695 D + G T + ++ + + + P + + G+Y C A N + Sbjct: 501 WALDDEPIVRD----GSHRT-----NQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLV 551 Query: 696 GNASTSATFN--GQATVLAIAPSHTLQEGTEANLTCNVSREAAGSP-ANFSWFRNGVLWA 752 G+A A N G ++ A+ + T G + + C V G P + W+++ +L Sbjct: 552 GSAEYQARINVRGPPSIRAMR-NITAVAGRDTLINCRV----IGYPYYSIKWYKDALLLP 606 Query: 753 QGPLE------TVTLLPVAR-TDAALYACRILTEAGAQLSTPVLLSVLYPP-----DRPK 800 + T+ L V + D Y C +L + +S V ++V PP + P Sbjct: 607 DNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPP 666 Query: 801 LSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLK 860 S G + C V S + + + + G + S +++ Sbjct: 667 ASI------GQLLYIPCVVSSGDMPIRITWRKD-------GQVIISGSGVTIESKEFMSS 713 Query: 861 LEVRELGLGDSGSYRCEATNVLG--SSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQV 918 L++ + L +G+Y C A+N S L +V +V + + G+A VL+C V Sbjct: 714 LQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSV 773 Query: 919 HTGVPEGTSYRWYR-DGQP-----------LQESTSATLRFAAITLTQAGAYHCQAQAPG 966 P ++ + G P +Q +++L + G Y CQA Sbjct: 774 DGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQAS--N 831 Query: 967 SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLV 1024 T ++ + L V + G L C + P +R GD ++ Sbjct: 832 GVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVI 889 Score = 68.6 bits (166), Expect = 5e-11 Identities = 128/550 (23%), Positives = 208/550 (37%), Gaps = 84/550 (15%) Query: 96 RVCNLLLKDLQPEDSGSYNFRFEISEV-NRWSDVKGTLVTVTEEPRVPTIASPVELLE-- 152 R+ L + DL+ EDSG+Y I EV N + + T + + +P T+ +P +L Sbjct: 335 RITGLTISDLRTEDSGTY-----ICEVTNTFGSAEATGILMVIDPLHVTL-TPKKLKTGI 388 Query: 153 GTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHG 212 G+ V +C+ + + ++W + + G+ + ETL + + + H Sbjct: 389 GSTVILSCA---LTGSPEFTIRWYRN---TELVLPDEAISIRGLSN-ETLLITSAQKSHS 441 Query: 213 RILRCQLSVANHRAQSEIHLQVKYAPKGV-KILLSPSGRNILPGELVTLTCQVNSSYP-- 269 +C A +AQ+ + G +I+ S S + + PGE +L C + P Sbjct: 442 GAYQC---FATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPT 498 Query: 270 ---AVSSIKWLKDG------VRLQTKTGVLHL----PQAAWSDAGVYTCQAENGVGSLVS 316 A+ ++DG + T + H+ PQ D GVY C A N VGS Sbjct: 499 VTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQI--RDGGVYRCTARNLVGSAE- 555 Query: 317 PPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDL------RYSWYKNHVLLEDA 370 + A + V I + +T V + WYK+ +LL D Sbjct: 556 -------YQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDN 608 Query: 371 H------SHTLRL-HLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLET 423 H + TL+L + D G Y C V S V V V PPL F Sbjct: 609 HRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPF-EFPPA 667 Query: 424 QAGLVGILHCSVVSEPL-ATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLE 482 G + + C V S + + G ++ S SG + S F + L+I + Sbjct: 668 SIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSS-------LQISSVS 720 Query: 483 ETDSGEYKCSATNSLGNATSTLDFHANA-ARLLISP-AAEVVEGQAVTLSCRSGLSPTPD 540 +G Y C A+N+ + R ++ P + + G+A L+C P P Sbjct: 721 LKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPK 780 Query: 541 ARFSWYLNGA-------------LLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPS 587 + + G+ + P SSLL+ D G Y C+A +G + S Sbjct: 781 VMWK-HAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNG-VGTDIS 838 Query: 588 SPAVLTVLYP 597 LTV P Sbjct: 839 KSMFLTVKIP 848 Score = 68.2 bits (165), Expect = 7e-11 Identities = 139/683 (20%), Positives = 239/683 (34%), Gaps = 92/683 (13%) Query: 250 RNILPGELVTLTCQVNSSYPAVSSIKWLKDG------VRLQTKTGVLHLPQAAWSDAGVY 303 + + G V L C S YP + +I+WLKDG R + L + D+G Y Sbjct: 295 QEVWAGHTVELPCTA-SGYP-IPAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSGTY 352 Query: 304 TCQAENGVGSLVSPPISLHIFMAEVQVSPAG-PILENQTVTLVCNTPNEAPSDLRYSWYK 362 C+ N GS + I + I V ++P TV L C +R WY+ Sbjct: 353 ICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIR--WYR 410 Query: 363 NH--VLLEDAHS------HTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLT 414 N VL ++A S TL + A ++ +G Y C ++ + +++ Sbjct: 411 NTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFA--TRKAQTAQDFAIIALEDGTP 468 Query: 415 PVLTAFLE--TQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPN 472 ++++F E G L C+ P T+ + + S + +++ + G Sbjct: 469 RIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDG--SHRTNQYTMSDGTT 526 Query: 473 SLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANA-ARLLISPAAEVVEGQAVTLSC 531 + + + D G Y+C+A N +G+A + + V G+ ++C Sbjct: 527 ISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINC 586 Query: 532 RSGLSPTPDARFSWYLNGALLHEG-------PGSSLLLPAASSTDAGSYHCRARDGHSAS 584 R + P WY + LL + G+ L D G Y C S Sbjct: 587 R--VIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLS 644 Query: 585 GPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDS-DPPARLQLLHKDRVV 643 S V + P QP + A G+ + C V S D P R+ +V+ Sbjct: 645 ISQSVHVAVKVPPLIQP-------FEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVI 697 Query: 644 ATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSAT 703 SG G + + + ++I + L+ G Y C ASNA S Sbjct: 698 I----SGSG----------VTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRE-- 741 Query: 704 FNGQATVLAIAPSHTLQE-------GTEANLTCNVS-----------REAAGSPANFSWF 745 + ++ + P +Q G L C+V + +G+P + Sbjct: 742 ---RQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPV 798 Query: 746 RNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP---PDRPKLS 802 P ++ + V D Y C+ G +S + L+V P P + Sbjct: 799 PLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTT 858 Query: 803 ALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSL--K 860 + +GH CT ++ G+ T + P K + + Sbjct: 859 IAI---KGHAKELNCTARGERPIIIRWEKGD----TVIDPDRVMRYAIATKDNGDEVVST 911 Query: 861 LEVRELGLGDSGSYRCEATNVLG 883 L+++ GDS + C A N G Sbjct: 912 LKLKPADRGDSVFFSCHAINSYG 934 Score = 62.8 bits (151), Expect = 3e-09 Identities = 137/621 (22%), Positives = 232/621 (37%), Gaps = 88/621 (14%) Query: 1065 YICEASNTLGQASASADFDAQAV-----NVQVWPGATVREGQLVNLTCLVWTTHPAQLTY 1119 Y C A N G+ S + +AV V+V ++R G + CL+ ++ ++ Sbjct: 161 YFCTAENAAGKIR-SPNIRVKAVFREPYTVRVEDQRSMR-GNVAVFKCLIPSSVQEYVSV 218 Query: 1120 -TWYQDGQQRLDAH--------SIPLPNVTVRDATS-YRC-------GVGPPGRAPRLSR 1162 +W +D + H + + +V DA S YRC G RLS Sbjct: 219 VSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS- 277 Query: 1163 PITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPN 1222 +T P L + E G + CT P + GR L + + + Sbjct: 278 -VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRI 336 Query: 1223 TLRLELRGPQPRDEGFYSCSARSPLGQAN-TSLELRLEGVRVILAPEAAVPE-GAPITVT 1280 T L + + D G Y C + G A T + + ++ + V L P+ G+ + ++ Sbjct: 337 T-GLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILS 395 Query: 1281 CADPAAHAPTLYTWYHNGRWLQEGPAASLSFLV--------ATRAHAGAYSCQAQDAQGT 1332 CA + T+ WY N + A S+ L A ++H+GAY C A T Sbjct: 396 CALTGSPEFTI-RWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFA-----T 449 Query: 1333 RSSRPAALQVLYAPQDA---VLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHDGKVLA 1387 R ++ A + A +D ++SSF + + C PP + + D + + Sbjct: 450 RKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIV 509 Query: 1388 TS----SGVHSLASGT--GHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQ 1441 + ++++ GT H+ V +R Y CTA+NL+GS R+ Sbjct: 510 RDGSHRTNQYTMSDGTTISHMNVTGPQIR--------DGGVYRCTARNLVGSAEYQARIN 561 Query: 1442 VEGARVV-AEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRL---HAEPV---P 1494 V G + A + G ++CR++G P + W+ + L H + V Sbjct: 562 VRGPPSIRAMRNITAVAGRDTLINCRVIGYP----YYSIKWYKDALLLPDNHRQVVFENG 617 Query: 1495 TLAFTHVARAQ-AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGIL- 1552 TL T V + G Y C + + S V + V PP + F P + +L Sbjct: 618 TLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPP---LIQPFEFPPASIGQLLY 674 Query: 1553 -DCRVDSEPLA-SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGE 1610 C V S + +T +++ S ++ + L I ++ G Sbjct: 675 IPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSL--------QISSVSLKHNGN 726 Query: 1611 YICSASNVLGSASTSTYFGVR 1631 Y C ASN + S VR Sbjct: 727 YTCIASNAAATVSRERQLIVR 747 Score = 61.2 bits (147), Expect = 8e-09 Identities = 117/524 (22%), Positives = 182/524 (34%), Gaps = 57/524 (10%) Query: 1052 LEIHGAMLEDEGVYICEASNTLGQASASADFDA-QAVNVQVWPGATVRE-GQLVNLTCLV 1109 L I ED G YICE +NT G A A+ ++V + P G V L+C + Sbjct: 339 LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCAL 398 Query: 1110 WTTHPAQLTYTWYQDGQQRLDAHSIP---LPNVTVRDATSYRCGVGP----PGRAPRLSR 1162 T + T WY++ + L +I L N T+ ++ + G R + ++ Sbjct: 399 --TGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQ 456 Query: 1163 PITLDVLY--APRNLRLTYLLESHGGQLALVLCTVDSRPPAQLAL-----------SHAG 1209 + L PR + + G+ ++C PP + SH Sbjct: 457 DFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRT 516 Query: 1210 RLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEA 1269 S ++ + + + GPQ RD G Y C+AR+ +G A + + G I A Sbjct: 517 NQYTMSDGTTISH---MNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRN 573 Query: 1270 AVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPA------ASLSFL-VATRAHAGAY 1322 T+ + WY + L + +L V G Y Sbjct: 574 ITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEY 633 Query: 1323 SCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDS-EPPAELALSH 1381 C S+ + V P F + + I C V S + P + Sbjct: 634 LCSVLIQPQLSISQSVHVAVKVPPLIQPFE-FPPASIGQLLYIPCVVSSGDMPIRITWRK 692 Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRL 1440 DG+V+ + SGV ++ LQ+ V + Y C A N ++S +L Sbjct: 693 DGQVIISGSGVT--------IESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQL 744 Query: 1441 QVE-GARVVAEPG-LDVPEGAALNLSCRLLGGPGPVGNSTFA-WFWNDRRLHAEPVP--- 1494 V R V +P D G A L+C + G P P A N ++ H P+ Sbjct: 745 IVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRI 804 Query: 1495 ------TLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYP 1532 +L HV G Y C A G S + L V P Sbjct: 805 QILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIP 848 Score = 52.0 bits (123), Expect = 5e-06 Identities = 69/281 (24%), Positives = 108/281 (38%), Gaps = 47/281 (16%) Query: 171 VRLQWQGQDPA----RSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRA 226 +R+ W+ VT S++F + +L ++ H C S A Sbjct: 686 IRITWRKDGQVIISGSGVTIESKEF-------MSSLQISSVSLKHNGNYTCIASNAAATV 738 Query: 227 QSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTK 286 E L V+ P+ V + P+ ++ + G+ L C V+ P K K Q Sbjct: 739 SRERQLIVRVPPRFV---VQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQY 795 Query: 287 -----TGVLH-LPQAAW-------SDAGVYTCQAENGVGSLVSPPISLHI-FMAEVQVSP 332 TG + LP ++ D G Y CQA NGVG+ +S + L + A + P Sbjct: 796 HPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHP 855 Query: 333 AGPI-LENQTVTLVCNTPNEAPSDLRYSWYKNHVLLE---------------DAHSHTLR 376 I ++ L C E P +R W K +++ D TL+ Sbjct: 856 NTTIAIKGHAKELNCTARGERPIIIR--WEKGDTVIDPDRVMRYAIATKDNGDEVVSTLK 913 Query: 377 LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVL 417 L A R D+ F+ C N +G +R G + + V PP P L Sbjct: 914 LKPADRGDSVFFSCHAINSYGEDR-GLIQLTVQEPPDPPEL 953 Score = 48.9 bits (115), Expect = 4e-05 Identities = 71/331 (21%), Positives = 109/331 (32%), Gaps = 34/331 (10%) Query: 1332 TRSSRPAALQVLYAPQD--AVLSSFRDSR--ARSMAVIQCTVDSEPPAELALSHDGKVLA 1387 TR S A L V + +L F A + CT P + DG+ L Sbjct: 268 TRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLP 327 Query: 1388 TSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQV-EGA 1445 S +G L + D+ D TY+C N GS G L V + Sbjct: 328 ADSRWTKRITG------------LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPL 375 Query: 1446 RVVAEPG-LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPV--------PTL 1496 V P L G+ + LSC L G P T W+ N + + TL Sbjct: 376 HVTLTPKKLKTGIGSTVILSCALTGSP----EFTIRWYRNTELVLPDEAISIRGLSNETL 431 Query: 1497 AFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRV 1556 T ++ +G Y C A A ++ P+ + G + L C Sbjct: 432 LITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAA 491 Query: 1557 DSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSAS 1616 P ++T L + G+ + +++ + D G Y C+A Sbjct: 492 KGAPPPTVTWALDDEPIVRD---GSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTAR 548 Query: 1617 NVLGSASTSTYFGVRALHRLHQFQQLLWVLG 1647 N++GSA VR + + + V G Sbjct: 549 NLVGSAEYQARINVRGPPSIRAMRNITAVAG 579 Score = 46.2 bits (108), Expect = 3e-04 Identities = 123/573 (21%), Positives = 201/573 (35%), Gaps = 80/573 (13%) Query: 1109 VWTTHPAQLTYT----------WYQDGQQRLDAHS--------IPLPNVTVRDATSYRCG 1150 VW H +L T W +DG+ L A S + + ++ D+ +Y C Sbjct: 297 VWAGHTVELPCTASGYPIPAIRWLKDGRP-LPADSRWTKRITGLTISDLRTEDSGTYICE 355 Query: 1151 VGPP-GRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAG 1209 V G A + +D L+ + L++ G ++ C + P + Sbjct: 356 VTNTFGSAEATGILMVIDPLHVTLTPKK---LKTGIGSTVILSCALTGSPEFTIRWYRNT 412 Query: 1210 RLLASSTAASVPNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG--VRVIL 1265 L+ A S+ L + Q G Y C A A + LE R++ Sbjct: 413 ELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVS 472 Query: 1266 A-PEAAVPEGAPITVTCADPAAHAPTLYTWY-----------HNGRWLQEGPAASLSFLV 1313 + E V G ++ CA A PT+ TW H ++S + Sbjct: 473 SFSEKVVNPGEQFSLMCAAKGAPPPTV-TWALDDEPIVRDGSHRTNQYTMSDGTTISHMN 531 Query: 1314 ATRAH---AGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVD 1370 T G Y C A++ G+ + A + V P + + R +I C V Sbjct: 532 VTGPQIRDGGVYRCTARNLVGSAEYQ-ARINVRGPPSIRAMRNITAVAGRD-TLINCRVI 589 Query: 1371 SEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDT--YVCTA- 1427 P + D +L + H QV L++ DV G D Y+C+ Sbjct: 590 GYPYYSIKWYKDALLLPDN-----------HRQVVFENGTLKLTDVQKGMDEGEYLCSVL 638 Query: 1428 -QNLLGSISTIGRLQVEGARVVAEPGLDVPE--GAALNLSCRLLGGPGPVGNSTFAWFWN 1484 Q L SIS + V+ ++ +P P G L + C + G P+ W + Sbjct: 639 IQPQL-SISQSVHVAVKVPPLI-QPFEFPPASIGQLLYIPCVVSSGDMPI---RITWRKD 693 Query: 1485 DRRLHA---------EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKT 1535 + + + E + +L + V+ G Y C+A A S L V PP+ Sbjct: 694 GQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIAS-NAAATVSRERQLIVRVPPRF 752 Query: 1536 PTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNA 1595 + G G+L+C VD P + Q P I +L + + Sbjct: 753 VVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSL 812 Query: 1596 LRVDIEALRPSDQGEYICSASNVLGSASTSTYF 1628 L I + D G Y+C ASN +G+ + + F Sbjct: 813 L---IRHVLEEDIGYYLCQASNGVGTDISKSMF 842 >gi|7657570 sialic acid binding Ig-like lectin 7 isoform 1 [Homo sapiens] Length = 467 Score = 90.5 bits (223), Expect = 1e-17 Identities = 86/344 (25%), Positives = 143/344 (41%), Gaps = 39/344 (11%) Query: 16 AGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVP-DGITAIWYY---DYSGQRQVVS 71 + + + ++ V +G C+ + C FS+P D + D + W+ D S + V + Sbjct: 21 SNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDPVHGYWFRAGNDISWKAPVAT 80 Query: 72 HSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGT 131 ++ V+ R R +G+P+ + C L ++D + D+G Y FR E + +W+ Sbjct: 81 NNP-AWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGRYFFRMEKGNI-KWNYKYDQ 138 Query: 132 L-VTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQ-EQVRLQWQGQ--DPARSVTFN 187 L V VT P I P L G + CS P+ C Q + W G P T Sbjct: 139 LSVNVTALTHRPNILIPGTLESGCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTR 198 Query: 188 SQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSV--ANHRAQSEIHLQVKYAPKGVKI-- 243 S L + Q HG L CQ+++ A I L V Y P+ + + Sbjct: 199 S-----------SVLTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTV 247 Query: 244 ----------LLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLP 293 L + S ++L G+ + L C V+S+ PA S W + + L L Sbjct: 248 FQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQPSNPLVLE 307 Query: 294 -QAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPI 336 Q D G +TC+A+N +G S +SL++ + + P+ Sbjct: 308 LQVHLGDEGEFTCRAQNSLG---SQHVSLNLSLQQEYTGKMRPV 348 Score = 62.4 bits (150), Expect = 4e-09 Identities = 75/260 (28%), Positives = 101/260 (38%), Gaps = 45/260 (17%) Query: 1035 EGSSPRLHVAVAPNTLR--LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVW 1092 E + R H+ P T L I A + D G Y G + +D +VNV Sbjct: 89 EETRDRFHLLGDPQTKNCTLSIRDARMSDAGRYFFRMEK--GNIKWNYKYDQLSVNVTAL 146 Query: 1093 --------PGATVREGQLVNLTCLV-WTTHPAQLTY-TWYQDGQQRLDAHS--------I 1134 PG T+ G NLTC V W +W L + I Sbjct: 147 THRPNILIPG-TLESGCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTRSSVLTLI 205 Query: 1135 PLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYL-------------- 1180 P P TS C V PG +R I L+V Y P+NL +T Sbjct: 206 PQPQ---HHGTSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNSS 262 Query: 1181 -LESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFY 1239 L GQ ++C VDS PPA+L+ + L S + N L LEL+ DEG + Sbjct: 263 SLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQPS---NPLVLELQ-VHLGDEGEF 318 Query: 1240 SCSARSPLGQANTSLELRLE 1259 +C A++ LG + SL L L+ Sbjct: 319 TCRAQNSLGSQHVSLNLSLQ 338 Score = 57.4 bits (137), Expect = 1e-07 Identities = 57/196 (29%), Positives = 81/196 (41%), Gaps = 43/196 (21%) Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPLE-------TVTLLPVARTDA 769 TL+ G NLTC+V G+P SW V PL +TL+P + Sbjct: 157 TLESGCFQNLTCSVPWACEQGTPPMISWMGTSV----SPLHPSTTRSSVLTLIPQPQHHG 212 Query: 770 ALYACRI-LTEAGAQLSTPVLLSVLYPPDRPKL---------------SALLDMGQGHMA 813 C++ L AG + + L+V YPP + S+ L + +G Sbjct: 213 TSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSL 272 Query: 814 LFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGS 873 +C VDS P A L+ + +L P PS N L LE+ ++ LGD G Sbjct: 273 RLVCAVDSNPPARLSWTWR----SLTLYPSQPS----------NPLVLEL-QVHLGDEGE 317 Query: 874 YRCEATNVLGSSNTSL 889 + C A N LGS + SL Sbjct: 318 FTCRAQNSLGSQHVSL 333 Score = 55.8 bits (133), Expect = 3e-07 Identities = 64/259 (24%), Positives = 100/259 (38%), Gaps = 50/259 (19%) Query: 855 EANSLKLEVRELGLGDSGSY--RCEATNVLGSSNTSLFFQVRGAWVQVSPSPE------L 906 + + L +R+ + D+G Y R E N+ + + Q+ ++ P L Sbjct: 102 QTKNCTLSIRDARMSDAGRYFFRMEKGNIKWNYK---YDQLSVNVTALTHRPNILIPGTL 158 Query: 907 QEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYH-----CQ 961 + G L+C V +GT G + +T R + +TL +H CQ Sbjct: 159 ESGCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQ 218 Query: 962 AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL---------------LLCR 1006 PG+ T+ I L+VSY P+++T+T G L L+C Sbjct: 219 VTLPGAGVTTNRT-IQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCA 277 Query: 1007 VDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYI 1066 VDS+PPA+L S L+ + N L LE+ L DEG + Sbjct: 278 VDSNPPARLSW-----------------TWRSLTLYPSQPSNPLVLELQ-VHLGDEGEFT 319 Query: 1067 CEASNTLGQASASADFDAQ 1085 C A N+LG S + Q Sbjct: 320 CRAQNSLGSQHVSLNLSLQ 338 Score = 42.4 bits (98), Expect = 0.004 Identities = 35/126 (27%), Positives = 49/126 (38%), Gaps = 31/126 (24%) Query: 592 LTVLYPPRQPTFTTRLDLDAAGAGAGRRGLL----------LCRVDSDPPARLQLLHKDR 641 L V YPP+ T T A G L +C VDS+PPARL + Sbjct: 234 LNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSL 293 Query: 642 VVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTS 701 + S PS P +L +++H L +EG + C A N+LG+ S Sbjct: 294 TLYPSQPSN------------------PLVLELQVH---LGDEGEFTCRAQNSLGSQHVS 332 Query: 702 ATFNGQ 707 + Q Sbjct: 333 LNLSLQ 338 Score = 40.0 bits (92), Expect = 0.019 Identities = 39/132 (29%), Positives = 52/132 (39%), Gaps = 33/132 (25%) Query: 1511 CLAELP-TGAAASAPVMLRVLYPPKTPTMMVFVEPEG----------------GLRGILD 1553 C LP G + + L V YPP+ T+ VF + EG G L Sbjct: 217 CQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVF-QGEGTASTALGNSSSLSVLEGQSLRLV 275 Query: 1554 CRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYIC 1613 C VDS P A L+ S + SQP ++P L + + D+GE+ C Sbjct: 276 CAVDSNPPARLSWTWRSLTLYPSQP------------SNPLVLELQVHL---GDEGEFTC 320 Query: 1614 SASNVLGSASTS 1625 A N LGS S Sbjct: 321 RAQNSLGSQHVS 332 Score = 38.9 bits (89), Expect = 0.043 Identities = 35/141 (24%), Positives = 54/141 (38%), Gaps = 30/141 (21%) Query: 1309 LSFLVATRAHAGAYSCQAQ-DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV--- 1364 L+ + + H + +CQ G ++R L V Y PQ+ ++ F+ S A+ Sbjct: 202 LTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNS 261 Query: 1365 ------------IQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQ 1412 + C VDS PPA L+ + L S N L L+ Sbjct: 262 SSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQ--------------PSNPLVLE 307 Query: 1413 VQDVPAGDDTYVCTAQNLLGS 1433 +Q + + C AQN LGS Sbjct: 308 LQVHLGDEGEFTCRAQNSLGS 328 Score = 31.6 bits (70), Expect = 6.9 Identities = 29/103 (28%), Positives = 43/103 (41%), Gaps = 4/103 (3%) Query: 516 SPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEG-PGSSLLLP-AASSTDAGSY 573 S + V+EGQ++ L C + P AR SW L+ P + L+L D G + Sbjct: 261 SSSLSVLEGQSLRLVC--AVDSNPPARLSWTWRSLTLYPSQPSNPLVLELQVHLGDEGEF 318 Query: 574 HCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGA 616 CRA++ + S L Y + + L GAGA Sbjct: 319 TCRAQNSLGSQHVSLNLSLQQEYTGKMRPVSGVLLGAVGGAGA 361 >gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens] Length = 708 Score = 90.1 bits (222), Expect = 2e-17 Identities = 119/437 (27%), Positives = 177/437 (40%), Gaps = 70/437 (16%) Query: 681 LEEEGLYLCEASNALGNASTSATFN----GQATVLAIAPSHTLQEGTEANLTCNVSREAA 736 LE+E Y C+A+ A G S A + +A + PS +L G ANLTC +A Sbjct: 95 LEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDAR 153 Query: 737 GSPANFSWFRNGVLW-------------AQGPLE-TVTLLPVARTDAALYACRILTEA-G 781 +P WFR+GVL G +E T+TL P + D A + CR ++A Sbjct: 154 PTP-ELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALP 212 Query: 782 AQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLG 841 T + LS+ YPP+ ++ + +G +F+C ++P + A Sbjct: 213 TGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT------GYRWAKGGS 266 Query: 842 PQVPSHG-RFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR-GAWVQ 899 P + + G R + A+A+ L V CE +N +GS+N S V G +Q Sbjct: 267 PVLGARGPRLEVVADASFLTEPVS-----------CEVSNAVGSANRSTALDVLFGPILQ 315 Query: 900 VSPSP-ELQEGQAVVLSCQVHTG-VPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGA 957 P P + G+ SC +P T W R G + ATLR ++ AG Sbjct: 316 AKPEPVSVDVGEDASFSCAWRGNPLPRVT---WTRRGGAQVLGSGATLRLPSVGPEDAGD 372 Query: 958 YHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRL---GLLLCRVDSDPPAQ 1014 Y C+A+A S AA L V+ P + T + + P L L C V + P Sbjct: 373 YVCRAEAGLSGLRGGAAEARLTVNAPP----VVTALHSAPAFLRGPARLQCLVFASPAP- 427 Query: 1015 LRLLHGDRLVASTLQGV--GGPEG-------SSPRLHVAVAPNTLR-LEIHGAMLED-EG 1063 D +V S +G G +G +P + P + L I G D Sbjct: 428 ------DAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSR 481 Query: 1064 VYICEASNTLGQASASA 1080 + C A N LG+ A A Sbjct: 482 SFNCSARNRLGEGGAQA 498 Score = 72.4 bits (176), Expect = 4e-12 Identities = 96/400 (24%), Positives = 150/400 (37%), Gaps = 72/400 (18%) Query: 244 LLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV-------------- 289 L P +L GE L C + + + V +W K G+ L + + Sbjct: 27 LQQPEDLVVLLGEEARLPCALGAYWGLV---QWTKSGLALGGQRDLPGWSRYWISGNAAN 83 Query: 290 ----LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA----EVQVSPAGPILENQT 341 LH+ D Y CQA L S P LH+ + +V P+ ++ Sbjct: 84 GQHDLHIRPVELEDEASYECQATQA--GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVP 141 Query: 342 VTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH--------------TLRLHLATRADTGF 387 L C + +A W+++ VLL+ A H TL L + D Sbjct: 142 ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGAT 201 Query: 388 YFCEVQN-VHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLS 446 + C ++ + R +++ + +PP + + Q G I C ++P T Sbjct: 202 FVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT---- 257 Query: 447 HGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDF 506 G+ A SP G GP RLE+ + C +N++G+A Sbjct: 258 --GYRWAKGG-----SPVL-GARGP---RLEVVADASFLTEPVSCEVSNAVGSAN----- 301 Query: 507 HANAARLLISPAAE-------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSS 559 + A +L P + V G+ + SC +P P R +W G G G++ Sbjct: 302 RSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLP--RVTWTRRGGAQVLGSGAT 359 Query: 560 LLLPAASSTDAGSYHCRARDGHSA-SGPSSPAVLTVLYPP 598 L LP+ DAG Y CRA G S G ++ A LTV PP Sbjct: 360 LRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPP 399 Score = 56.6 bits (135), Expect = 2e-07 Identities = 115/477 (24%), Positives = 165/477 (34%), Gaps = 67/477 (14%) Query: 861 LEVRELGLGDSGSYRCEATNV-LGSSNTSLFFQVRGAWVQV--SPSPELQEGQAVVLSCQ 917 L +R + L D SY C+AT L S L V QV PS L G L+C+ Sbjct: 88 LHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCR 147 Query: 918 VHTGVPEGTSYRWYRDGQPLQEST--------------SATLRFAAITLTQAGAYHCQAQ 963 W+RDG L +T +TL + + C+A+ Sbjct: 148 SRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRAR 207 Query: 964 APGSATTSLAAPISLHVSYAPRHVTLTTLMDT-GPGRLGLLLCRVDSDPPAQ-LRLLHGD 1021 + + T I+L + Y P VTL+ T G + LC+ + PP R G Sbjct: 208 SQ-ALPTGRDTAITLSLQYPP-EVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKG- 264 Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081 S + G G PRL V + L + CE SN +G A+ S Sbjct: 265 ---GSPVLGARG-----PRLEVVADASFLTEPVS-----------CEVSNAVGSANRSTA 305 Query: 1082 FDAQ-AVNVQVWP-GATVREGQLVNLTCLVWTTHP-AQLTYTWYQDGQQRLDAHSIPLPN 1138 D +Q P +V G+ + +C W +P ++T+T Q ++ LP+ Sbjct: 306 LDVLFGPILQAKPEPVSVDVGEDASFSC-AWRGNPLPRVTWTRRGGAQVLGSGATLRLPS 364 Query: 1139 VTVRDATSYRC----------GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQL 1188 V DA Y C G R + P+ + AP LR L+ Sbjct: 365 VGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFAS 424 Query: 1189 ALVLCTVDSRPPAQLALSHAGRLLASSTAASV------PNTLR-LELRGPQPRD-EGFYS 1240 V S L GR L + A P + L + G Q D ++ Sbjct: 425 PAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFN 484 Query: 1241 CSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN 1297 CSAR+ LG+ L R L P + G T L W H+ Sbjct: 485 CSARNRLGEGGAQASLG----RRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHS 537 Score = 48.1 bits (113), Expect = 7e-05 Identities = 111/483 (22%), Positives = 164/483 (33%), Gaps = 71/483 (14%) Query: 1226 LELRGPQPRDEGFYSCSARSPLGQANTSLELRL----EGVRVILAPEAAVPEGAPITVTC 1281 L +R + DE Y C A + G + +L + E +V+ P ++ G P +TC Sbjct: 88 LHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 146 Query: 1282 ADPAAHAPT-LYTWYHNG----------RWLQEGPAAS----LSFLVATRAHAGAYSCQA 1326 PT W+ +G L+EG S L+ + + C+A Sbjct: 147 RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 206 Query: 1327 Q-DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKV 1385 + A T L + Y P+ + +S + + C ++PP Sbjct: 207 RSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT--------- 257 Query: 1386 LATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV-EG 1444 + A G V AR V D + C N +GS + L V G Sbjct: 258 ------GYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFG 311 Query: 1445 ARVVAEP-GLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPV---PTLAFTH 1500 + A+P + V G + SC G P P W RR A+ + TL Sbjct: 312 PILQAKPEPVSVDVGEDASFSCAWRGNPLP----RVTW---TRRGGAQVLGSGATLRLPS 364 Query: 1501 VARAQAGMYHCLAELP----TGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRG--ILDC 1554 V AG Y C AE G AA A + + P + LRG L C Sbjct: 365 VGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNA-----PPVVTALHSAPAFLRGPARLQC 419 Query: 1555 RVDSEPLASLTLHLGSRLVASSQPQGA------PAEPHIHVLASPNALRV-DIEALRPSD 1607 V + P + + QG PA P P + V I + SD Sbjct: 420 LVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPA-PESRGGLGPGLISVLHISGTQESD 478 Query: 1608 -QGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWR 1666 + CSA N LG G R L L + + V LL+++ G+ C WR Sbjct: 479 FSRSFNCSARNRLGEGGAQASLGRRDL--LPTVRIVAGVAAATTTLLMVITGVALC-CWR 535 Query: 1667 RRR 1669 + Sbjct: 536 HSK 538 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.133 0.402 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 72,691,363 Number of Sequences: 37866 Number of extensions: 3649134 Number of successful extensions: 21491 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 214 Number of HSP's successfully gapped in prelim test: 280 Number of HSP's that attempted gapping in prelim test: 10018 Number of HSP's gapped (non-prelim): 6409 length of query: 1709 length of database: 18,247,518 effective HSP length: 116 effective length of query: 1593 effective length of database: 13,855,062 effective search space: 22071113766 effective search space used: 22071113766 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.