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Search of human proteins with 13489095
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13489095 sialoadhesin precursor [Homo sapiens]
(1709 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13489095 sialoadhesin precursor [Homo sapiens] 3435 0.0
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 205 3e-52
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 205 3e-52
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 205 3e-52
gi|110349719 titin isoform N2-A [Homo sapiens] 201 5e-51
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 185 3e-46
gi|157168355 CD22 molecule [Homo sapiens] 178 4e-44
gi|118572606 hemicentin 1 [Homo sapiens] 170 1e-41
gi|11225258 myelin associated glycoprotein isoform a precursor [... 143 1e-33
gi|18104957 myelin associated glycoprotein isoform b precursor [... 143 1e-33
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 134 6e-31
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact... 119 3e-26
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 119 3e-26
gi|98986445 carcinoembryonic antigen-related cell adhesion molec... 109 3e-23
gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Ho... 108 6e-23
gi|31377639 sialic acid binding Ig-like lectin 10 [Homo sapiens] 108 6e-23
gi|144226847 obscurin-like 1 [Homo sapiens] 106 2e-22
gi|193794821 sialic acid binding Ig-like lectin 6 isoform 1 prec... 100 2e-20
gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Ho... 99 3e-20
gi|193794817 sialic acid binding Ig-like lectin 6 isoform 3 prec... 99 4e-20
gi|193794819 sialic acid binding Ig-like lectin 6 isoform 2 prec... 97 2e-19
gi|23943856 sialic acid binding Ig-like lectin 9 [Homo sapiens] 96 2e-19
gi|94538343 sialic acid binding Ig-like lectin 8 [Homo sapiens] 96 2e-19
gi|16506826 sialic acid binding immunoglobulin-like lectin-like ... 96 4e-19
gi|16506828 sialic acid binding immunoglobulin-like lectin-like ... 96 4e-19
gi|157694526 Fc receptor-like 5 [Homo sapiens] 93 3e-18
gi|15147240 brother of CDO [Homo sapiens] 92 4e-18
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 92 6e-18
gi|7657570 sialic acid binding Ig-like lectin 7 isoform 1 [Homo ... 91 1e-17
gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens] 90 2e-17
>gi|13489095 sialoadhesin precursor [Homo sapiens]
Length = 1709
Score = 3435 bits (8906), Expect = 0.0
Identities = 1709/1709 (100%), Positives = 1709/1709 (100%)
Query: 1 MGFLPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWY 60
MGFLPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWY
Sbjct: 1 MGFLPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWY 60
Query: 61 YDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEIS 120
YDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEIS
Sbjct: 61 YDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEIS 120
Query: 121 EVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDP 180
EVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDP
Sbjct: 121 EVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDP 180
Query: 181 ARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKG 240
ARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKG
Sbjct: 181 ARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKG 240
Query: 241 VKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSDA 300
VKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSDA
Sbjct: 241 VKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSDA 300
Query: 301 GVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSW 360
GVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSW
Sbjct: 301 GVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSW 360
Query: 361 YKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF 420
YKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF
Sbjct: 361 YKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF 420
Query: 421 LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRD 480
LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRD
Sbjct: 421 LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRD 480
Query: 481 LEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPD 540
LEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPD
Sbjct: 481 LEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPD 540
Query: 541 ARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQ 600
ARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQ
Sbjct: 541 ARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQ 600
Query: 601 PTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCS 660
PTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCS
Sbjct: 601 PTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCS 660
Query: 661 PRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQ 720
PRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQ
Sbjct: 661 PRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQ 720
Query: 721 EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEA 780
EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEA
Sbjct: 721 EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEA 780
Query: 781 GAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSL 840
GAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSL
Sbjct: 781 GAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSL 840
Query: 841 GPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV 900
GPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV
Sbjct: 841 GPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV 900
Query: 901 SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHC 960
SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHC
Sbjct: 901 SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHC 960
Query: 961 QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020
QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG
Sbjct: 961 QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020
Query: 1021 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080
DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA
Sbjct: 1021 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080
Query: 1081 DFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVT 1140
DFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVT
Sbjct: 1081 DFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVT 1140
Query: 1141 VRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPP 1200
VRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPP
Sbjct: 1141 VRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPP 1200
Query: 1201 AQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG 1260
AQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG
Sbjct: 1201 AQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG 1260
Query: 1261 VRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRAHAG 1320
VRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRAHAG
Sbjct: 1261 VRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRAHAG 1320
Query: 1321 AYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALS 1380
AYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALS
Sbjct: 1321 AYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALS 1380
Query: 1381 HDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRL 1440
HDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRL
Sbjct: 1381 HDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRL 1440
Query: 1441 QVEGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTH 1500
QVEGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTH
Sbjct: 1441 QVEGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTH 1500
Query: 1501 VARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEP 1560
VARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEP
Sbjct: 1501 VARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEP 1560
Query: 1561 LASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620
LASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG
Sbjct: 1561 LASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620
Query: 1621 SASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCKQSMGENSV 1680
SASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCKQSMGENSV
Sbjct: 1621 SASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCKQSMGENSV 1680
Query: 1681 EMAFQKETTQLIDPDAATCETSTCAPPLG 1709
EMAFQKETTQLIDPDAATCETSTCAPPLG
Sbjct: 1681 EMAFQKETTQLIDPDAATCETSTCAPPLG 1709
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 205 bits (522), Expect = 3e-52
Identities = 356/1491 (23%), Positives = 543/1491 (36%), Gaps = 255/1491 (17%)
Query: 259 TLTCQVNSSYPAVSSIKWLKDGV------RLQTKTG--VLHLPQAAWSDAGVYTCQAENG 310
T++ Q + V +I WL++G+ RLQ VL + A +DA Y C AEN
Sbjct: 1671 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ 1730
Query: 311 VGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLR------YSWYKNH 364
GS +F VQV P L+ + VT + N+ P D+ +WYK+
Sbjct: 1731 AGSAEK------LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDS 1784
Query: 365 VLLEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSERS-GPVSVVV----NHPP 412
L +HTL+L A +D+G Y CE N G ++ +SV+V P
Sbjct: 1785 QALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAP 1844
Query: 413 LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPN 472
P + + G +L C + P T+ G L R G
Sbjct: 1845 RGPQDAVLV--RVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQ-------RTQALRGGQ 1895
Query: 473 SLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE---GQAVTL 529
RLEI++ + +D G Y C +N G A T +P E V G + L
Sbjct: 1896 --RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVL 1953
Query: 530 SCRSGLSPTPDARFSWY-----LNGALLH--EGPGSSLLLPAASSTDAGSYHCRARDGHS 582
+C +S P +W + + +H G L L AG+Y C A + +
Sbjct: 1954 TC--DVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA 2011
Query: 583 ASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRV 642
+ V+ VL PR + + G+ L C D PP + L
Sbjct: 2012 EA--RKDFVVAVLVAPRIRSSGVAREHHVL---EGQEVRLDCEADGQPPPDVAWLKDGSP 2066
Query: 643 VATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSA 702
+ + GG S +K +A + G Y C A N G +
Sbjct: 2067 LGQDMGPHLRFYLDGG-SLVLKGLRA-------------SDAGAYTCVAHNPAGEDARLH 2112
Query: 703 TFNGQATVLAIAPSHTLQEGTEAN---------LTCNVSREAAGSPANFSWFRNGV---- 749
T N + + P T+++G + + L V P + SW ++G+
Sbjct: 2113 TVN-----VLVPP--TIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL 2165
Query: 750 ---LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLD 806
G T+ + V DA ++ C + AG L V PP + D
Sbjct: 2166 SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGV-ADRNFTLQVQVPPVLEPVEFQND 2224
Query: 807 --MGQGHMALFICTVDSRPLALLA-LFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
+ +G + C PL L++ + GE LL+ SL Q PS L++
Sbjct: 2225 VVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSL-EQGPS--------------LQL 2269
Query: 864 RELGLGDSGSYRCEATNVLGSSNTSLFFQV-RGAWVQVSPSP---ELQEGQAVVLSCQVH 919
+G GDSG+Y C A + G + V ++ S P L G + L C
Sbjct: 2270 EAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 2329
Query: 920 TGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSA-----TTSLAA 974
G P+ + W++DGQ L + + + + AG Y C A++P A + A
Sbjct: 2330 -GTPQ-PNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQA 2387
Query: 975 PISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034
P ++ PR V + PG+L +L C V+++P ++ H D +V
Sbjct: 2388 PPNIVGPRGPRFV-----VGLAPGQL-VLECSVEAEPAPKI-TWHRDGIVL--------- 2431
Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG 1094
H L++ D G Y C A N G S A V++
Sbjct: 2432 ---QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSV-------AFRVEIHTV 2481
Query: 1095 ATVREGQ-----LVNLTCLVWTTH---PAQLTYTWYQDGQ---------QRLDAHSIPLP 1137
T+R G VN T L+ PA L +W +D + L S+ +
Sbjct: 2482 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLV-SWRKDRVPLDPRSPRFEILPEGSLRIQ 2540
Query: 1138 NVTVRDATSYRC------GVGPPGRAPRLSRPITLDVLYAPRNLRLT------YLLESHG 1185
V +DA Y C G GR R+ P + +P NL LT E+ G
Sbjct: 2541 PVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPA--IAPSPSNLTLTAHTPALLPCEASG 2598
Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARS 1245
LV+ D + A RLL S+ L L P P+D + C +
Sbjct: 2599 SPKPLVVWWKDGQKLDFRLQQGAYRLLPSNA---------LLLTAPGPQDSAQFECVVSN 2649
Query: 1246 PLGQANTSLELRLEGVRVILAPEAA-------VPEGAPITVTCADPAAHAPTLYTWYHNG 1298
+G+A+ RL V V + P A V AP+ +TC APT+ +W G
Sbjct: 2650 EVGEAH-----RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTV-SWSKAG 2703
Query: 1299 RWL-------QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVL 1351
L + P+ +L A HAG Y+C A+++ G + + L V +P L
Sbjct: 2704 AQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPL 2762
Query: 1352 SSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRL 1411
S + A ++ C P + +G +AT GV + G +++A +
Sbjct: 2763 PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVAT--GVSTQVLPGGQLRIAHAS--- 2817
Query: 1412 QVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAE--PGLDVPEGAALNLSCRLLG 1469
P Y+C A+N GS RL V+ V+ P L EG+ L C+ G
Sbjct: 2818 -----PEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARG 2872
Query: 1470 GPGPVGNSTFAWFWN---------DRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAA 1520
P P N T W+ + + +P L ++ AG Y C AE G A
Sbjct: 2873 SPEP--NIT----WDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRA 2926
Query: 1521 ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQG 1580
V L +L P T+ G R L C P + + R V
Sbjct: 2927 RRR-VHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG---- 2981
Query: 1581 APAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
V + A+ D G Y+C A N +G ++ V+
Sbjct: 2982 --------VSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 3024
Score = 202 bits (513), Expect = 3e-51
Identities = 373/1573 (23%), Positives = 580/1573 (36%), Gaps = 263/1573 (16%)
Query: 194 TGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNIL 253
+ VG L L A Q+ C V N + ++ L+V P+ P+ +++
Sbjct: 1023 SAVGRLLYLGQAQLAQEGTYTCECSNVVGN--SSQDLQLEVHVPPQIAGPREPPTQVSVV 1080
Query: 254 PGELVTLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTC 305
+ TL C P ++ W +DG ++LQ + LH+ +A + G Y+C
Sbjct: 1081 QDGVATLECNATGKPPP--TVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 1138
Query: 306 QAENGVGSLVSPPISLHIFMAEVQVSPAGPILE-----NQTVTLVCNTPNEAPSDLRYSW 360
AEN G L + + + P+ + +TL+C P +R W
Sbjct: 1139 VAENLAGR-AERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIR--W 1195
Query: 361 YKNHVLL---EDAH----SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413
++ + ED + L++ D+G Y C N G R SV V PP
Sbjct: 1196 FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRN-FSVEVLVPPS 1254
Query: 414 --TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGP 471
L ++ G L C+V P L G LA GD+ H P
Sbjct: 1255 IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR--GDAHHI-------SP 1305
Query: 472 NSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAE-------VVEG 524
+ + L++ + +G Y C A N++G T A ++ A + V
Sbjct: 1306 DGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVN 1365
Query: 525 QAVTLSCRSGLSPTPDARFSWYLNGALLHEG------PGS-SLLLPAASSTDAGSYHCRA 577
++L C + P+P+ +W +GA PG+ L + A DAG Y C
Sbjct: 1366 NPISLICEALAFPSPN--ITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVV 1423
Query: 578 RDGHSASGPSSPAVLTVLYPPR--QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635
+ + + + VL PP + + + L C + PP ++
Sbjct: 1424 TNELGEAVKNYH--VEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIR 1481
Query: 636 LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695
+KD T S R++V LL+++ + + G YLC A+N
Sbjct: 1482 W-YKDGQPVTP-------------SSRLQVLGEGRLLQIQPTQ--VSDSGRYLCVATNVA 1525
Query: 696 GNASTS--------------ATFNGQATVLA--------IAPSHTLQEGTEANLTCNVSR 733
G F+ +L+ + + E A L C+ +
Sbjct: 1526 GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTN- 1584
Query: 734 EAAGSPANFSWFRNGVLWAQGPLETVTL------LPVARTD-AALYACRILTEAGAQLST 786
A P + +W+R + G +V +P+ R + A Y+C+ E G
Sbjct: 1585 --AIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 1642
Query: 787 PVLLSVLYPP----DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGP 842
LL VL PP D +L + + C P+ ++ + S
Sbjct: 1643 YELL-VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRL 1701
Query: 843 QVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSP 902
QV G+ L+V + D+ SY C A N GS+ F +R VQV P
Sbjct: 1702 QVLEDGQV----------LQVSTAEVADAASYMCVAENQAGSAEK--LFTLR---VQVPP 1746
Query: 903 ---SPELQEGQAVV-----LSCQVHTGV-PEGTSYRWYRDGQPLQESTSA-------TLR 946
+L++ A++ L C VH PE T WY+D Q L TL+
Sbjct: 1747 RIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT---WYKDSQALSLGEEVFLLPGTHTLQ 1803
Query: 947 FAAITLTQAGAYHCQA-QAPG--SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLL 1003
L+ +G Y C+A A G L+ + APR L+ G +L
Sbjct: 1804 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDK--AVL 1861
Query: 1004 LCRVDSDP-PAQLRLLHGDRLV-ASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061
C D+ P P G LV A Q + G + RLEI A + D
Sbjct: 1862 SCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ---------------RLEIQEAQVSD 1906
Query: 1062 EGVYICEASNTLGQASASADFDAQAVNVQVWPGA-TVRE--GQLVNLTCLVWTTHPAQLT 1118
+G+Y C+ SN G+A + Q P TV + G + LTC V + PA T
Sbjct: 1907 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAP-T 1964
Query: 1119 YTWYQDGQQRLDAHSIPLPNVTVR------------DATSYRCGVGPPGRAPRLSRPITL 1166
TW +D R+ S + V R A +Y C R + +
Sbjct: 1965 VTWLKD---RMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR--KDFVV 2019
Query: 1167 DVLYAPRNLRLTYLLESH---GGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT 1223
VL APR +R + + H GQ + C D +PP +A G L +
Sbjct: 2020 AVLVAPR-IRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY 2078
Query: 1224 L---RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP---EAAVPEGAPI 1277
L L L+G + D G Y+C A +P G+ + RL V V++ P + A G +
Sbjct: 2079 LDGGSLVLKGLRASDAGAYTCVAHNPAGE-----DARLHTVNVLVPPTIKQGADGSGTLV 2133
Query: 1278 T-----VTCADPAAHAPTLY-TWYHNG-------RWLQEGPAASLSFLVATRAHAGAYSC 1324
+ VT P +P ++ +W +G R L G +L A AG ++C
Sbjct: 2134 SRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC 2193
Query: 1325 QAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRA--RSMAVIQCTVDSEPPAELALSHD 1382
A G + R LQV P + D S+ + C P ++ D
Sbjct: 2194 VAASPAGV-ADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD 2252
Query: 1383 GKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQ 1441
G+ L + SL G LQ++ V AGD TY C A + G +L
Sbjct: 2253 GEPLLS----QSLEQGPS----------LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 2298
Query: 1442 VEGARVVAEPG----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLA 1497
V + + G L + GA + L C G P P W + + L + A
Sbjct: 2299 VMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQP----NITWHKDGQALTRLENNSRA 2354
Query: 1498 FTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYP-----PKTPTMMVFVEPEGGLRGIL 1552
+ AG+Y CLAE P GA + +RV P P+ P +V + P G L +L
Sbjct: 2355 TRVLRVRDAGLYTCLAESPAGAIEKS-FRVRVQAPPNIVGPRGPRFVVGLAP-GQL--VL 2410
Query: 1553 DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612
+C V++EP +T H G + H + ++AL +D G+Y
Sbjct: 2411 ECSVEAEPAPKITWH----------RDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYS 2460
Query: 1613 CSASNVLGSASTS 1625
C+A N GS S +
Sbjct: 2461 CTARNAAGSTSVA 2473
Score = 201 bits (510), Expect = 7e-51
Identities = 379/1557 (24%), Positives = 563/1557 (36%), Gaps = 298/1557 (19%)
Query: 258 VTLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTCQAEN 309
V+L C V++ +P + W KD V L T L L +A SD+G+YTC+A N
Sbjct: 1764 VSLPCDVHA-HPN-PEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALN 1821
Query: 310 GVG---SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVL 366
G LV + + + P +L V + +A + +WYK+
Sbjct: 1822 AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQP 1881
Query: 367 LEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPP-LTPVLT 418
L A L + A +D G Y C+V NV G E ++ V PP T
Sbjct: 1882 LVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKT 1940
Query: 419 AFLETQAGLVGILHCSVVSEPLATL--------VLSHGGHILASTSGDSDHSPRFSGTSG 470
+ AG +L C V P T+ V S H + S G
Sbjct: 1941 ETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGG------------- 1987
Query: 471 PNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN---AARLLISPAAE---VVEG 524
RL++ L+ +G Y C A N+ A DF A R+ S A V+EG
Sbjct: 1988 ----RLQLSRLQPAQAGTYTCVAENTQAEARK--DFVVAVLVAPRIRSSGVAREHHVLEG 2041
Query: 525 QAVTLSCRSGLSPTPDARFSWYLNGALLHE--GP-------GSSLLLPAASSTDAGSYHC 575
Q V L C + P PD +W +G+ L + GP G SL+L ++DAG+Y C
Sbjct: 2042 QEVRLDCEADGQPPPDV--AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2099
Query: 576 RARDGHSASGPSSPA-VLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLL---CRVDSDPP 631
A H+ +G + + VL PP T + D +G R G L+ C V PP
Sbjct: 2100 VA---HNPAGEDARLHTVNVLVPP-----TIKQGADGSGTLVSRPGELVTMVCPVRGSPP 2151
Query: 632 ARLQLL------------------HKDRVVATSLPSGGGCSTCGGCSPR--------MKV 665
+ L H R+ L + G TC SP ++V
Sbjct: 2152 IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQL-ADAGIFTCVAASPAGVADRNFTLQV 2210
Query: 666 TKAPNLLRVEIHNPLLEEEGLYL---CEASN----------------------------- 693
P L VE N ++ G + CEA
Sbjct: 2211 QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLE 2270
Query: 694 ALGNASTSATFN-------GQAT----VLAIAPSHTLQEG--TEANLTCNVSRE----AA 736
A+G A S T++ G+A + + P H G TE +LT E A
Sbjct: 2271 AVG-AGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 2329
Query: 737 GSPA-NFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP 795
G+P N +W ++G + + + DA LY C + AGA + + V P
Sbjct: 2330 GTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGA-IEKSFRVRVQAP 2388
Query: 796 PD-----RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRF 850
P+ P+ L GQ + C+V++ P + +L Q P GRF
Sbjct: 2389 PNIVGPRGPRFVVGLAPGQ---LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF 2445
Query: 851 QAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV----SPSPEL 906
L+++ L DSG Y C A N GS TS+ F+V V P+ +
Sbjct: 2446 ----------LQLQALSTADSGDYSCTARNAAGS--TSVAFRVEIHTVPTIRSGPPAVNV 2493
Query: 907 QEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST-------SATLRFAAITLTQAGAYH 959
Q +L CQ GVP W +D PL + +LR + AG Y
Sbjct: 2494 SVNQTALLPCQAD-GVP-APLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL 2551
Query: 960 CQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDP-PAQLRL 1017
C A + GS + + AP LT T LL C P P +
Sbjct: 2552 CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTP----ALLPCEASGSPKPLVVWW 2607
Query: 1018 LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQAS 1077
G +L QG S+ L A P +D + C SN +G+A
Sbjct: 2608 KDGQKLDFRLQQGAYRLLPSNALLLTAPGP------------QDSAQFECVVSNEVGEAH 2655
Query: 1078 ASADFDAQAVNVQVWPGATVREGQ----LVNLTCLVWTTHPAQL---TYTWYQDGQQRLD 1130
V V V P T+ + Q + + +V T H + T +W + G Q L
Sbjct: 2656 R-----LYQVTVHVPP--TIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ-LG 2707
Query: 1131 AHSIPLPNVTVRDATSYRCGVGPPGRAPRLS-----------RPITLDVLYAPRNLRLTY 1179
A V + + G P A R + + + L V +P L
Sbjct: 2708 ARG---SGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPS 2764
Query: 1180 LLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFY 1239
++ + + L+ C P + G +A+ + V +L + P D G Y
Sbjct: 2765 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNY 2824
Query: 1240 SCSARSPLGQA--NTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN 1297
C A++ G A T L +++ V P+ + EG+ + C + P + TW +
Sbjct: 2825 LCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNI-TWDKD 2883
Query: 1298 GRWLQ--EG-----PAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAV 1350
G+ + EG P+ L AG Y+C A++A G R+ R L +L P
Sbjct: 2884 GQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG-RARRRVHLTILVLPVFTT 2942
Query: 1351 LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR 1410
L R R ++C P + + + + + S V+R
Sbjct: 2943 LPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSRE--- 2999
Query: 1411 LQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV---AEPGLDVPEGAALNLSCRL 1467
TYVC A+N +G + + V+ A V+ A L P G ++ L C +
Sbjct: 3000 --------DSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV 3051
Query: 1468 LGGPGPVGNSTFAWFWNDRRL------HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAA 1521
G P P W + L H +L R AG Y CLAE G A
Sbjct: 3052 RGDPVP----DIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAK 3107
Query: 1522 SAPVMLRVLYPPKTPTMMVF-VEPE-----GGLRGILDCRVDSEPLASLT-LHLGSRLVA 1574
+++ P VF VEP+ G L C+ EP ++ L G L A
Sbjct: 3108 KVVILVLQSAP-------VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRA 3160
Query: 1575 SSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
S + + P + +E + D G Y C A N+LGSA+ + VR
Sbjct: 3161 SRRLRTLPDGS------------LWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3205
Score = 179 bits (454), Expect = 2e-44
Identities = 398/1681 (23%), Positives = 604/1681 (35%), Gaps = 297/1681 (17%)
Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRV---PTIASPVELLEGTEV 156
L ++ Q D+GSY R S V ++++ L V PR+ P++ PV L T V
Sbjct: 750 LRIEQAQLSDAGSY--RCVASNVAGSTELRYGL-RVNVPPRITLPPSLPGPV--LVNTPV 804
Query: 157 DFNCSTPYVCLQEQVRLQW--QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRI 214
C+ L W G + + T Q F G + TL A + D GR
Sbjct: 805 RLTCNATGA---PSPTLMWLKDGNPVSPAGTPGLQVFPG---GRVLTLASARA-SDSGRY 857
Query: 215 LRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSI 274
+S Q ++ LQV P IL +++ E V L CQ ++ P V S
Sbjct: 858 SCVAVSAVGEDRQ-DVVLQVHMPPS---ILGEELNVSVVANESVALECQSHAMPPPVLS- 912
Query: 275 KWLKDGVRLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA 326
W KDG L+ + GV L + +A DAG YTC+A N G S +
Sbjct: 913 -WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGR------SEKHYNL 965
Query: 327 EVQVSPAGPILENQTVTLVCNTPNEAPSDLR------YSWYKNHVLLE---------DAH 371
V V+P P+ E+ T+T+ P + R SW K+ L A
Sbjct: 966 NVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAV 1025
Query: 372 SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTP----VLTAFLETQAGL 427
L L A A G Y CE NV G+ S + + V+ PP T Q G
Sbjct: 1026 GRLLYLGQAQLAQEGTYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDG- 1083
Query: 428 VGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
V L C+ +P T+ G + + G + S L + + +G
Sbjct: 1084 VATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQS---------LHVERAQAAHTG 1134
Query: 488 EYKCSATNSLGNATSTLDFHANAARLLIS---PAAEVVEG--QAVTLSCRSGLSPTPDAR 542
Y C A N G A + LI P + +TL C + P P R
Sbjct: 1135 RYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIR 1194
Query: 543 FSWYLNGALLHEGPGSSLL-------LPAASSTDAGSYHCRARDGHSASGPSSPAVLTVL 595
W+ + G + LL + D+G Y C A + A + VL
Sbjct: 1195 --WFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA--SNEAGEARRNFSVEVL 1250
Query: 596 YPPRQPTFTTRLDLDAA-GAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCS 654
PP DL+ G+ L+C V P +L R +A
Sbjct: 1251 VPPS----IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR--------- 1297
Query: 655 TCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIA 714
G + + +P+ + +++ L G Y C A+NA+G T + Q +VL +A
Sbjct: 1298 ---GDAHHI----SPDGVLLQVLQANLSSAGHYSCIAANAVG----EKTKHFQLSVL-LA 1345
Query: 715 PS--HTLQEGTEANLTCNVSR------EAAGSPA-NFSWFRNGVLWAQGPLETVTLLP-- 763
P+ ++ + +T V+ EA P+ N +W ++G + + LLP
Sbjct: 1346 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEAS--RNIQLLPGT 1403
Query: 764 -------VARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFI 816
+ DA Y C + E G + + VL PP K L ++G + +
Sbjct: 1404 HGLQILNAQKEDAGQYTCVVTNELGEAVKN-YHVEVLIPPSISKDDPLGEVGVKEVKTKV 1462
Query: 817 -------CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869
C + P + + + S QV GR L+++ +
Sbjct: 1463 NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL----------LQIQPTQVS 1512
Query: 870 DSGSYRCEATNVLGSSNTSL--------FFQVRG--------------AWVQVSPSPELQ 907
DSG Y C ATNV G + FQ G A V+ E+
Sbjct: 1513 DSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIV 1572
Query: 908 EGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT-------LRFAAITLTQAGAYHC 960
E L C + P + WYR+ QPL + L+ + AG Y C
Sbjct: 1573 ENNPAYLYCDTNAIPPPDLT--WYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSC 1630
Query: 961 QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020
+A ++ LH Y +T ++ + + S Q L
Sbjct: 1631 KA-------SNEVGEDWLH--YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN 1681
Query: 1021 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080
S LQ G P SPRL V L++ A + D Y+C A N G A
Sbjct: 1682 PVPTISWLQN-GLPFSPSPRLQVLEDGQV--LQVSTAEVADAASYMCVAENQAGSAE--- 1735
Query: 1081 DFDAQAVNVQVWP--------GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL--- 1129
+ VQV P T V+L C V HP TWY+D Q
Sbjct: 1736 --KLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDV-HAHP-NPEVTWYKDSQALSLGE 1791
Query: 1130 ------DAHSIPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVL------YAPRNLR 1176
H++ L + D+ Y C + GR +L + L VL APR +
Sbjct: 1792 EVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL---VQLSVLVPPAFRQAPRGPQ 1848
Query: 1177 LTYLLESHGGQLALVLCTVDSRPPAQLALSHAGR-LLASSTAASVPNTLRLELRGPQPRD 1235
L+ G A++ C D+ P + G+ L+ + ++ RLE++ Q D
Sbjct: 1849 DAVLVRV--GDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSD 1906
Query: 1236 EGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE---GAPITVTCADPAAHAPTLY 1292
+G YSC + G+A + L ++ P+ G+P+ +TC APT+
Sbjct: 1907 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV- 1965
Query: 1293 TWYHNGRWLQEGP-------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYA 1345
TW + ++ L A AG Y+C A++ Q + + + VL A
Sbjct: 1966 TWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQ-AEARKDFVVAVLVA 2024
Query: 1346 PQDAVLSSFRDSRARSMAVIQ--CTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403
P+ R+ ++ C D +PP ++A DG L G H G
Sbjct: 2025 PRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSL 2084
Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV-------EGA----RVVAEPG 1452
V + L+ D A Y C A N G + + + V +GA +V+ P
Sbjct: 2085 VLKG---LRASDAGA----YTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRP- 2136
Query: 1453 LDVPEGAALNLSCRLLGGPGPVGNSTFAWF-------WNDRRLHAEPVPTLAFTHVARAQ 1505
G + + C + G P P+ S W + R L TL + V A
Sbjct: 2137 -----GELVTMVCPVRGSP-PIHVS---WLKDGLPLPLSQRTLLHGSGHTLRISKVQLAD 2187
Query: 1506 AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI---LDCRVDSEPLA 1562
AG++ C+A P G A L+V PP + F +RG L C PL
Sbjct: 2188 AGIFTCVAASPAG-VADRNFTLQVQVPPVLEP-VEFQNDVVVVRGSLVELPCEARGVPLP 2245
Query: 1563 SLT-LHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621
++ + G L++ S QG + +EA+ D G Y C A + G
Sbjct: 2246 LVSWMKDGEPLLSQSLEQGP---------------SLQLEAVGAGDSGTYSCVAVSEAGE 2290
Query: 1622 A 1622
A
Sbjct: 2291 A 2291
Score = 176 bits (445), Expect = 2e-43
Identities = 378/1579 (23%), Positives = 578/1579 (36%), Gaps = 296/1579 (18%)
Query: 200 ETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVT 259
++LH+ + H C RA+ + L V P+ + L + +T
Sbjct: 1121 QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLT 1180
Query: 260 LTCQVNSSYPAVSSIKWLK--------DGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGV 311
L C+ P +I+W + + L +L + Q D+G+Y+C A N
Sbjct: 1181 LLCEAMGIPPP--AIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEA 1238
Query: 312 GSLVSPPISLHIFMAEVQVSPAGP---------ILENQTVTLVCNTPNEAPSDLRYSWYK 362
G + F EV V P+ +L+ QT L+CN L +W+K
Sbjct: 1239 GE------ARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFK 1290
Query: 363 NHVLLEDAHSH-------TLRLHLATRADTGFYFCEVQNVHGSE-RSGPVSVVVNHPPLT 414
+ L +H L++ A + G Y C N G + + +SV+ L
Sbjct: 1291 DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL-----LA 1345
Query: 415 PVLTAFLETQAG---LVGI-----LHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466
P + E A V + L C ++ P + G + S +
Sbjct: 1346 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEA----SRNIQLLP 1401
Query: 467 GTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA-------- 518
GT G L+I + ++ D+G+Y C TN LG A ++H +LI P+
Sbjct: 1402 GTHG-----LQILNAQKEDAGQYTCVVTNELGEAVK--NYH---VEVLIPPSISKDDPLG 1451
Query: 519 ------AEVVEGQAVTLSCRSGLSPTPDARFSWYLNG-------ALLHEGPGSSLLLPAA 565
+ +TL C S P P R WY +G L G G L +
Sbjct: 1452 EVGVKEVKTKVNSTLTLECESWAVPPPTIR--WYKDGQPVTPSSRLQVLGEGRLLQIQPT 1509
Query: 566 SSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP---RQPTFTTRLDL-----DAAGAGAG 617
+D+G Y C A + ++ V PP + F+ ++ +A G
Sbjct: 1510 QVSDSGRYLCVATNVAGEDDQDFNVLIQV--PPMFQKVGDFSAAFEILSREEEARGGVTE 1567
Query: 618 RRGL-------LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPN 670
R + L C ++ PP L +D+ L +G S G +V + P
Sbjct: 1568 YREIVENNPAYLYCDTNAIPPPDLTWYREDQ----PLSAGDEVSVLQG----GRVLQIP- 1618
Query: 671 LLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCN 730
L+R E G Y C+ASN +G + + + L E N +
Sbjct: 1619 LVRA-------ENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASST 1671
Query: 731 VSRE--AAGSPA-NFSWFRNGVLWAQGP----LETVTLLPVAR---TDAALYACRILTEA 780
VS + A G+P SW +NG+ ++ P LE +L V+ DAA Y C +A
Sbjct: 1672 VSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQA 1731
Query: 781 GAQLSTPVLLSVLYPP-----DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHL 835
G+ L V PP D +++A+L+ C V + P + +
Sbjct: 1732 GS-AEKLFTLRVQVPPRIAGLDLEQVTAILNSS----VSLPCDVHAHPNPEVTWYKDSQ- 1785
Query: 836 LATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN--TSLFFQV 893
A SLG +V + L++ L DSG Y CEA N G L V
Sbjct: 1786 -ALSLGEEV--------FLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV 1836
Query: 894 RGAWVQVSPSPE----LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP--LQESTSA---- 943
A+ Q P+ ++ G VLSC+ +PE T WY+DGQP L + T A
Sbjct: 1837 PPAFRQAPRGPQDAVLVRVGDKAVLSCET-DALPEPT-VTWYKDGQPLVLAQRTQALRGG 1894
Query: 944 -TLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYA-PRHVTLTTLMDTGPGRL 1000
L ++ G Y C+ + G A + + + ++ P+ T++ + G
Sbjct: 1895 QRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQV----AGSP 1950
Query: 1001 GLLLCRVDSDPPAQLRLLHGDRL--VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAM 1058
+L C V P + L DR+ +S + GV G RL++
Sbjct: 1951 LVLTCDVSGVPAPTVTWLK-DRMPVESSAVHGVVSRGG--------------RLQLSRLQ 1995
Query: 1059 LEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGAT---------VREGQLVNLTCLV 1109
G Y C A NT QA A DF V V V P V EGQ V L C
Sbjct: 1996 PAQAGTYTCVAENT--QAEARKDF---VVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEA 2050
Query: 1110 WTTHPAQLTYTWYQDGQQ-----------RLDAHSIPLPNVTVRDATSYRC-GVGPPGRA 1157
P + W +DG LD S+ L + DA +Y C P G
Sbjct: 2051 DGQPPPDV--AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 2108
Query: 1158 PRLSRPITLDVLYAP---RNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLAS 1214
RL T++VL P + + L S G+L ++C V PP ++ G L
Sbjct: 2109 ARLH---TVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL 2165
Query: 1215 STAASVPNT-LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP-----E 1268
S + + L + Q D G ++C A SP G A+ + L+++ V +L P +
Sbjct: 2166 SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ-VPPVLEPVEFQND 2224
Query: 1269 AAVPEGAPITVTCADPAAHAPTLYTWYHNG-----RWLQEGPAASLSFLVATRAHAGAYS 1323
V G+ + + C P L +W +G + L++GP+ L + A +G YS
Sbjct: 2225 VVVVRGSLVELPCEARGVPLP-LVSWMKDGEPLLSQSLEQGPSLQLEAVGA--GDSGTYS 2281
Query: 1324 CQAQDAQGTRSSRPAALQVLYAP--QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSH 1381
C A G + R L V+ P +D+ + + + C P +
Sbjct: 2282 CVAVSEAG-EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK 2340
Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQ 1441
DG+ L T +R L+V+D Y C A++ G+I R+
Sbjct: 2341 DGQAL------------TRLENNSRATRVLRVRDA----GLYTCLAESPAGAIEKSFRV- 2383
Query: 1442 VEGARVVAEPGLDVPEG---------AALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP 1492
RV A P + P G L L C + P P W D + E
Sbjct: 2384 ----RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAP----KITWH-RDGIVLQED 2434
Query: 1493 VPT--------LAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLY--PPKTPTMMVFV 1542
T L ++ A +G Y C A AA S V RV P + V
Sbjct: 2435 AHTQFPERGRFLQLQALSTADSGDYSCTAR---NAAGSTSVAFRVEIHTVPTIRSGPPAV 2491
Query: 1543 EPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEA 1602
+L C+ D P A L R+ P P +L +LR I+
Sbjct: 2492 NVSVNQTALLPCQADGVP-APLVSWRKDRVPLD------PRSPRFEILPE-GSLR--IQP 2541
Query: 1603 LRPSDQGEYICSASNVLGS 1621
+ D G Y+C ASN GS
Sbjct: 2542 VLAQDAGHYLCLASNSAGS 2560
Score = 175 bits (444), Expect = 3e-43
Identities = 366/1579 (23%), Positives = 562/1579 (35%), Gaps = 275/1579 (17%)
Query: 201 TLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQV--KYAPKGVKILL-----SPSGRNIL 253
TLH+ DH + CQ + A +E+ + V ++AP +++ + +
Sbjct: 553 TLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSF 612
Query: 254 PGELVTLTCQVNSSYPAVSSIK-WLKDGVRLQTKTGV---------LHLPQAAWSDAGVY 303
P + ++P ++ W G TG+ L + + D G+Y
Sbjct: 613 PAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIY 672
Query: 304 TCQAENGVGSLVSPPISLHIFMAEVQVSPAG-PILENQTVTLVCNTPNEAPSDLRYSWYK 362
TC A N G + ++ P +LEN +VTL C P D+ SW+K
Sbjct: 673 TCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDV--SWFK 730
Query: 363 NHV-------LLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPP--- 412
H + LR+ A +D G Y C NV GS + VN PP
Sbjct: 731 GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL-RYGLRVNVPPRIT 789
Query: 413 LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSG-- 470
L P L + + L C+ P TL+ G+ ++ +GT G
Sbjct: 790 LPPSLPGPVLVNTPV--RLTCNATGAPSPTLMWLKDGNPVSP-----------AGTPGLQ 836
Query: 471 --PNSLRLEIRDLEETDSGEYKCSATNSLGNATS--TLDFHANAARLLISPAAEVVEGQA 526
P L + +DSG Y C A +++G L H + L VV ++
Sbjct: 837 VFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANES 896
Query: 527 VTLSCRSGLSPTPDARFSWYLNGALLHEGPG-------SSLLLPAASSTDAGSYHCRA-- 577
V L C+S P P SW+ +G L PG + L + A DAG Y C A
Sbjct: 897 VALECQSHAMPPP--VLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALN 954
Query: 578 RDGHSASGPSSPAVLTVLYPPRQP-TFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQL 636
+ G S + + ++P R+ T T R G L C P ++
Sbjct: 955 QAGRSEKHYNLNVWVAPVFPLRESHTLTVR---------EGHPTSLSCECRGVPFPKISW 1005
Query: 637 LHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG 696
R LP G + V+ LL + L +EG Y CE SN +G
Sbjct: 1006 ----RKDGQPLPGEG--------AGLQHVSAVGRLL--YLGQAQLAQEGTYTCECSNVVG 1051
Query: 697 NASTSATFNGQATVLAIAPSH------TLQEGTEANLTCNVSREAAGSPANFSWFRNGV- 749
N+S P +Q+G A L CN + + P +W R+G
Sbjct: 1052 NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGV-ATLECNATGK---PPPTVTWERDGQP 1107
Query: 750 ------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDR-PKLS 802
L Q +++ + Y+C + + LSVL PP+ L
Sbjct: 1108 VGAELGLQLQNQGQSLHVERAQAAHTGRYSC-VAENLAGRAERKFELSVLVPPELIGDLD 1166
Query: 803 ALLDMGQG-HMAL-FICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLK 860
L ++ H L +C P + F GE P P + A
Sbjct: 1167 PLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEE-------PVSPGEDTYLL---AGGWM 1216
Query: 861 LEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPE---------LQEGQA 911
L++ + DSG Y C A+N G + + + V V PS E + +GQ
Sbjct: 1217 LKMTQTQEQDSGLYSCLASNEAGEARRNFSVE-----VLVPPSIENEDLEEVIKVLDGQT 1271
Query: 912 VVLSCQVHTGVPEGTSYRWYRDGQPLQESTS-------ATLRFAAITLTQAGAYHC-QAQ 963
L C V TG P+ W++DG+PL + L+ L+ AG Y C A
Sbjct: 1272 AHLMCNV-TGHPQ-PKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 1329
Query: 964 APGSAT-----TSLAAPISL--HVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLR 1016
A G T + L AP L A VT+T L+C + P +
Sbjct: 1330 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPIS------LICEALAFPSPNI- 1382
Query: 1017 LLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQA 1076
T G P +S ++ + P T L+I A ED G Y C +N LG+A
Sbjct: 1383 ----------TWMKDGAPFEAS--RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEA 1430
Query: 1077 ------------SASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQD 1124
S S D V V+ + + L C W P T WY+D
Sbjct: 1431 VKNYHVEVLIPPSISKDDPLGEVGVK---EVKTKVNSTLTLECESWAVPPP--TIRWYKD 1485
Query: 1125 GQ-----QRL----DAHSIPLPNVTVRDATSYRC-GVGPPG----------RAPRLSRPI 1164
GQ RL + + + V D+ Y C G + P + + +
Sbjct: 1486 GQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKV 1545
Query: 1165 -----TLDVLYAPRNLR--LTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTA 1217
++L R +T E A + C ++ PP L + L++
Sbjct: 1546 GDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDE 1605
Query: 1218 ASVPNTLR-LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVI------LAPEAA 1270
SV R L++ + + G YSC A + +G+ EL + VI L E
Sbjct: 1606 VSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVT 1665
Query: 1271 VPEGAPITVTCADPAAHAPTLYTWYHNG---------RWLQEGPAASLSFLVATRAHAGA 1321
V + +++ C PT+ +W NG + L++G +S A A A +
Sbjct: 1666 VNASSTVSLQCPALGNPVPTI-SWLQNGLPFSPSPRLQVLEDGQVLQVS--TAEVADAAS 1722
Query: 1322 YSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV-IQCTVDSEPPAELALS 1380
Y C A++ G+ + + L+V P+ A L + + + +V + C V + P E+
Sbjct: 1723 YMCVAENQAGS-AEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWY 1781
Query: 1381 HDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRL 1440
D + L+ V L GT +Q+ R L + Y C A N G + +L
Sbjct: 1782 KDSQALSLGEEVF-LLPGTHTLQLGRARL--------SDSGMYTCEALNAAGRDQKLVQL 1832
Query: 1441 QV------EGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRL----HA 1490
V A + + V G LSC P P T W+ + + L
Sbjct: 1833 SVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEP----TVTWYKDGQPLVLAQRT 1888
Query: 1491 EPVPTLAFTHVARAQA---GMYHCLAELPTGAAASAPVMLRVLYP----PKTPTMMVFVE 1543
+ + + AQ G+Y C G A + + P PKT T V
Sbjct: 1889 QALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTET----VS 1944
Query: 1544 PEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEAL 1603
G +L C V P ++T V SS +H + S R+ + L
Sbjct: 1945 QVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSA---------VHGVVSRGG-RLQLSRL 1994
Query: 1604 RPSDQGEYICSASNVLGSA 1622
+P+ G Y C A N A
Sbjct: 1995 QPAQAGTYTCVAENTQAEA 2013
Score = 156 bits (395), Expect = 1e-37
Identities = 304/1275 (23%), Positives = 456/1275 (35%), Gaps = 220/1275 (17%)
Query: 476 LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE-----------G 524
L + + DSG+Y+C ATN +G+ + A+L++ + E G
Sbjct: 59 LFLASVSPADSGDYECQATNEVGST-------SRRAKLVVYVPPSIREDGRKANVSGMAG 111
Query: 525 QAVTLSCRSGLSPTPD----------------ARFSWYLNGA------LLHEGPGSSLLL 562
Q++TL C + P P+ A + W L LL E G SL
Sbjct: 112 QSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDE--GQSLHF 169
Query: 563 PAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLL 622
P +G +A P + P F+ GAGA + L
Sbjct: 170 PRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLG 229
Query: 623 LCRVD-------SDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVE 675
L D S P KDR LP G P ++V + +LR
Sbjct: 230 LAGADVELQCWTSGVPTPQVEWTKDR--QPVLPGG----------PHLQVQEDGQVLR-- 275
Query: 676 IHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREA 735
I + +EG Y C A + G + A + T + + + EA
Sbjct: 276 ITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEA 335
Query: 736 AGSPA-NFSWFRNG--------VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLST 786
G P N +WF++G V++ +G + + L +DA +Y C+ GA
Sbjct: 336 RGVPTPNITWFKDGALLPTSTKVVYTRGGRQ-LQLGRAQSSDAGVYTCKASNAVGA-AEK 393
Query: 787 PVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPS 846
L V PP G G + V RP+AL + G P +
Sbjct: 394 ATRLDVYVPPTIE--------GAGGRPYVVKAVAGRPVALECVARGHP------SPTLSW 439
Query: 847 HGRFQAKAEANSLKLE-------VRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQ 899
H AE+N +LE + G SG Y C A++ G + L + V VQ
Sbjct: 440 HHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA--VLQYSVE---VQ 494
Query: 900 VSPSPELQE---------GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQE-------STSA 943
V P + E GQ + L CQ +G P T +W ++G+P +E S
Sbjct: 495 VPPQLLVAEGLGQVTTIVGQPLELPCQA-SGSPVPT-IQWLQNGRPAEELAGVQVASQGT 552
Query: 944 TLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLL 1003
TL + L +G + CQA + T +S+H +AP V + G
Sbjct: 553 TLHIDHVELDHSGLFACQA-TNEAGTAGAEVEVSVHGEWAP-GVLEVPIGQYHWGXEHHS 610
Query: 1004 LCRVDSDPPAQLRL-LHGDRLVASTLQGVGGPEGSSPRLHVAVA-PNTLRLEIHGAMLED 1061
DPP H + G G + VA + P L++E L D
Sbjct: 611 SFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIE--KVDLRD 668
Query: 1062 EGVYICEASNTLGQASASADFDAQA-VNVQVWP-GATVREGQLVNLTCLVWTTHPAQLTY 1119
EG+Y C A+N G++ N++ P V E V L CL P +
Sbjct: 669 EGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDV-- 726
Query: 1120 TWYQDGQQ---------RLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV-- 1168
+W++ Q +D + + + DA SYRC + L + ++V
Sbjct: 727 SWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPP 786
Query: 1169 -LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASV---PNTL 1224
+ P +L L+ + + C P L G ++ + + P
Sbjct: 787 RITLPPSLPGPVLVNTP----VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGR 842
Query: 1225 RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPE--AAVPEGAPITVTCA 1282
L L + D G YSC A S +G+ + L++ IL E +V + + C
Sbjct: 843 VLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQ 902
Query: 1283 DPAAHAPTLYTWYHNGRWLQEGPAASLS----FLVATRA---HAGAYSCQAQDAQGTRSS 1335
A P L +W+ +GR L+ P LS L RA AG Y+C+A + G RS
Sbjct: 903 SHAMPPPVL-SWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAG-RSE 960
Query: 1336 RPAALQVLYAP----QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSG 1391
+ L V AP +++ + R+ S++ C P +++ DG+ L
Sbjct: 961 KHYNLNVWVAPVFPLRESHTLTVREGHPTSLS---CECRGVPFPKISWRKDGQPLPGE-- 1015
Query: 1392 VHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEP 1451
+G HV L L Q A + TY C N++G+ S +L+V +A P
Sbjct: 1016 ----GAGLQHVSAVGRLLYLG-QAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGP 1070
Query: 1452 -----GLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTL----AFTHVA 1502
+ V + L C G P P T W + + + AE L HV
Sbjct: 1071 REPPTQVSVVQDGVATLECNATGKPPP----TVTWERDGQPVGAELGLQLQNQGQSLHVE 1126
Query: 1503 RAQA---GMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSE 1559
RAQA G Y C+AE G A L VL PP+ L G LD
Sbjct: 1127 RAQAAHTGRYSCVAENLAG-RAERKFELSVLVPPE-------------LIGDLD------ 1166
Query: 1560 PLASLTLHLGSRLVASSQPQG------------APAEPHIHVLASPNALRVDIEALRPSD 1607
PL ++T L S L + G P P + + + D
Sbjct: 1167 PLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQD 1226
Query: 1608 QGEYICSASNVLGSA 1622
G Y C ASN G A
Sbjct: 1227 SGLYSCLASNEAGEA 1241
Score = 152 bits (385), Expect = 2e-36
Identities = 358/1572 (22%), Positives = 539/1572 (34%), Gaps = 279/1572 (17%)
Query: 210 DHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYP 269
D GR S A +A+ + L+V +AP + ++ LV L C+
Sbjct: 283 DEGRYQCVAFSPAGQQAR-DFQLRV-HAPPTIWGSNETGEVAVMEDHLVQLLCEARGV-- 338
Query: 270 AVSSIKWLKDGVRLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISL 321
+I W KDG L T T V L L +A SDAGVYTC+A N VG+ L
Sbjct: 339 PTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA-AEKATRL 397
Query: 322 HIFMAEVQVSPAG-----PILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH----- 371
+++ G + + V L C L SW+ + + +++
Sbjct: 398 DVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL--SWHHEGLPVAESNESRLE 455
Query: 372 --SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF--LETQAGL 427
LRL A +G Y C + G E SV V PP V + T G
Sbjct: 456 TDGSVLRLESPGEASSGLYSCVASSPAG-EAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQ 514
Query: 428 VGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
L C P+ T+ G +G S GT+ L I +E SG
Sbjct: 515 PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVAS---QGTT------LHIDHVELDHSG 565
Query: 488 EYKCSATNSLGNATSTLDFHAN---AARLLISPAAEVVEG----QAVTLSCRS------G 534
+ C ATN G A + ++ + A +L P + G + +C G
Sbjct: 566 LFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWG 625
Query: 535 LSPTPDARFSWYLNGALLHEGPG--------SSLLLPAASSTDAGSYHCRARDGHSASGP 586
P P W G+L E G L + D G Y C A + A
Sbjct: 626 AHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT--NLAGES 683
Query: 587 SSPAVLTVLYPPR-QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVAT 645
L VL PP +P + L+ A L C PP + + V
Sbjct: 684 KREVALKVLVPPNIEPGPVNKAVLENASV------TLECLASGVPPPDVSWFKGHQPV-- 735
Query: 646 SLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFN 705
S M VT + + + I L + G Y C ASN G ST +
Sbjct: 736 --------------SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG--STELRYG 779
Query: 706 GQATV---LAIAPS--HTLQEGTEANLTCNVSREAAGSPA-NFSWFRNG--VLWAQGP-- 755
+ V + + PS + T LTCN A G+P+ W ++G V A P
Sbjct: 780 LRVNVPPRITLPPSLPGPVLVNTPVRLTCN----ATGAPSPTLMWLKDGNPVSPAGTPGL 835
Query: 756 -----LETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQG 810
+TL +D+ Y+C ++ G V+L V PP + +
Sbjct: 836 QVFPGGRVLTLASARASDSGRYSCVAVSAVGED-RQDVVLQVHMPPSILGEELNVSVVAN 894
Query: 811 HMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGD 870
C + P +L+ + P R A+ L+V + D
Sbjct: 895 ESVALECQSHAMPPPVLSWWKDGR----------PLEPRPGVHLSADKALLQVDRADVWD 944
Query: 871 SGSYRCEATNVLGSSNTSLFFQVRGAWV------QVSPSPELQEGQAVVLSCQVHTGVPE 924
+G Y CEA N G S V WV + S + ++EG LSC+ GVP
Sbjct: 945 AGHYTCEALNQAGRSEKHYNLNV---WVAPVFPLRESHTLTVREGHPTSLSCECR-GVP- 999
Query: 925 GTSYRWYRDGQPLQESTSATLRFAAI---------TLTQAGAYHCQ-AQAPGSATTSLAA 974
W +DGQPL + +A+ L Q G Y C+ + G+++ L
Sbjct: 1000 FPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQL 1059
Query: 975 PISLHVSYA-PRH-VTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVG 1032
+ + A PR T +++ G + L C PP + T + G
Sbjct: 1060 EVHVPPQIAGPREPPTQVSVVQDG---VATLECNATGKPPPTV-----------TWERDG 1105
Query: 1033 GPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVW 1092
P G+ L + +L +E A G Y C A N G+A + ++V V
Sbjct: 1106 QPVGAELGLQLQNQGQSLHVE--RAQAAHTGRYSCVAENLAGRAERKFE-----LSVLVP 1158
Query: 1093 PGATVREGQLVNLTCLVWTTHPAQL----------TYTWY---------QDGQQRLDAHS 1133
P L N+T + + P L W+ +D
Sbjct: 1159 PELIGDLDPLTNITAALHS--PLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM 1216
Query: 1134 IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAP--RNLRLTYLLESHGGQLALV 1191
+ + +D+ Y C A R +++VL P N L +++ GQ A +
Sbjct: 1217 LKMTQTQEQDSGLYSCLAS--NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHL 1274
Query: 1192 LCTVDSRPPAQLALSHAGRLLASSTAASV-PNTLRLELRGPQPRDEGFYSCSARSPLGQA 1250
+C V P +L GR LA A + P+ + L++ G YSC A + +G+
Sbjct: 1275 MCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEK 1334
Query: 1251 NTSLELRLEGVRVILAP------------EAAVPEGAPITVTCADPAAHAPTLYTWYHNG 1298
+L V+LAP E V PI++ C A +P + TW +G
Sbjct: 1335 TKHFQL-----SVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNI-TWMKDG 1388
Query: 1299 ------RWLQEGPAA-SLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP---QD 1348
R +Q P L L A + AG Y+C + G + + ++VL P +D
Sbjct: 1389 APFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG-EAVKNYHVEVLIPPSISKD 1447
Query: 1349 AVLSSFR----DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQV 1404
L ++ S ++C + PP + DG+ + SS + L G
Sbjct: 1448 DPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR----- 1502
Query: 1405 ARNALRLQVQDVPAGDD-TYVCTAQNLLGS--------------ISTIGRLQV------- 1442
LQ+Q D Y+C A N+ G +G
Sbjct: 1503 -----LLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSR 1557
Query: 1443 -EGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA-------EPVP 1494
E AR ++ E L C P P W+ D+ L A +
Sbjct: 1558 EEEARGGVTEYREIVENNPAYLYCDTNAIPPP----DLTWYREDQPLSAGDEVSVLQGGR 1613
Query: 1495 TLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPP----KTPTMMVFVEPEGGLRG 1550
L V AG Y C A G +L VL PP T ++ V
Sbjct: 1614 VLQIPLVRAENAGRYSCKASNEVGEDWLHYELL-VLTPPVILGDTEELVEEVTVNASSTV 1672
Query: 1551 ILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGE 1610
L C P+ ++ S G P P + + + + +D
Sbjct: 1673 SLQCPALGNPVPTI----------SWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAAS 1722
Query: 1611 YICSASNVLGSA 1622
Y+C A N GSA
Sbjct: 1723 YMCVAENQAGSA 1734
Score = 148 bits (374), Expect = 4e-35
Identities = 309/1299 (23%), Positives = 445/1299 (34%), Gaps = 234/1299 (18%)
Query: 251 NILPGELVTLTCQVNSSYPAVSSIKWLKDG----------VRLQTKTGVLHLPQAAWSDA 300
++L G+ V L C+ + P + WLKDG +R G L L SDA
Sbjct: 2037 HVLEGQEVRLDCEADGQPPP--DVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA 2094
Query: 301 GVYTCQAENGVGS---------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNE 351
G YTC A N G LV P I + VS G + VT+VC
Sbjct: 2095 GAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGEL-----VTMVCPVRGS 2149
Query: 352 APSDLRYSWYKNHVLLE-------DAHSHTLRLHLATRADTGFYFCEVQNVHG-SERSGP 403
P + SW K+ + L HTLR+ AD G + C + G ++R+
Sbjct: 2150 PP--IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFT 2207
Query: 404 VSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP 463
+ V V P L PV E Q +V VV L L G L S D P
Sbjct: 2208 LQVQVP-PVLEPV-----EFQNDVV------VVRGSLVELPCEARGVPLPLVSWMKDGEP 2255
Query: 464 RFSGT--SGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEV 521
S + GP+ L++ + DSG Y C A + G A ++ P
Sbjct: 2256 LLSQSLEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQL------TVMEPPHIE 2306
Query: 522 VEGQAVTLSCRSGL--------SPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSY 573
GQ LS G TP +W+ +G L +S DAG Y
Sbjct: 2307 DSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLY 2366
Query: 574 HCRARDGHSASGPSSPAVLTV---LYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDP 630
C A A S + + PR P F L A + +L C V+++P
Sbjct: 2367 TCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGL--------APGQLVLECSVEAEP 2418
Query: 631 PARLQLLHKDRVVA-----TSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685
++ H+D +V T P G +++ + G
Sbjct: 2419 APKITW-HRDGIVLQEDAHTQFPERGRF--------------------LQLQALSTADSG 2457
Query: 686 LYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANF-SW 744
Y C A NA G STS F + + S N T + +A G PA SW
Sbjct: 2458 DYSCTARNAAG--STSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSW 2515
Query: 745 FRNGV-------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPD 797
++ V + P ++ + PV DA Y C AG+ L VL PP
Sbjct: 2516 RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDL-RVLEPPA 2574
Query: 798 RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEAN 857
+ L + AL C P L+ + L L G ++ +N
Sbjct: 2575 IAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL-----QQGAYRL-LPSN 2628
Query: 858 SLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQA------ 911
+L L G DS + C +N +G ++ R V V P + + Q
Sbjct: 2629 ALLLTAP--GPQDSAQFECVVSNEVGEAH-------RLYQVTVHVPPTIADDQTDFTVTM 2679
Query: 912 ---VVLSCQVHTGVPEGTSYRWYRDGQPL-------QESTSATLRFAAITLTQAGAYHCQ 961
VVL+C TG+P T W + G L + S S L AG Y C
Sbjct: 2680 MAPVVLTCH-STGIPAPT-VSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCS 2737
Query: 962 AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGD 1021
A+ + L V +P L +++ LL C P +
Sbjct: 2738 ARNSAGVAHK---HVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG 2794
Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081
VA+ + P G +L I A ED G Y+C A N+ G A
Sbjct: 2795 LNVATGVSTQVLPGG--------------QLRIAHASPEDAGNYLCIAKNSAGSAMGKTR 2840
Query: 1082 FDAQAVNV--QVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS------ 1133
Q V P + EG L C + +T W +DGQ A
Sbjct: 2841 LVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNIT--WDKDGQPVSGAEGKFTIQP 2898
Query: 1134 ---IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAP--------RNLRLTYLL- 1181
+ + N+ +DA +Y C R R + L +L P R+LRL L
Sbjct: 2899 SGELLVKNLEGQDAGTYTCTA--ENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLW 2956
Query: 1182 ---ESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGF 1238
+ G + TV+ RP + G A S D G
Sbjct: 2957 LRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVS-------------REDSGT 3003
Query: 1239 YSCSARSPLGQANTSLELRLEGVRVILAPEAAV---PEGAPITVTCADPAAHAPTLYTWY 1295
Y C A + +G+ + ++ V+ + P G I + C P ++ W
Sbjct: 3004 YVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIH-WI 3062
Query: 1296 HNG---------RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP 1346
+G LQ G SL+ R AG Y C A++ G + + L + AP
Sbjct: 3063 KDGLPLRGSHLRHQLQNG---SLTIHRTERDDAGRYQCLAENEMGV-AKKVVILVLQSAP 3118
Query: 1347 QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVAR 1406
V R+ ++C EP + G+ L S + +L G+
Sbjct: 3119 VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGS------- 3171
Query: 1407 NALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQVEG 1444
L +++V GD TY C A NLLGS + L V G
Sbjct: 3172 ----LWLENVETGDAGTYDCVAHNLLGSATARAFLVVRG 3206
Score = 144 bits (362), Expect = 1e-33
Identities = 356/1523 (23%), Positives = 529/1523 (34%), Gaps = 293/1523 (19%)
Query: 250 RNILPGELVTLTCQVNSSYPAVSSIKWLK--------DGVRLQTKTGVLHLPQAAWSDAG 301
R I+ L C N+ P + W + D V + VL +P +AG
Sbjct: 1569 REIVENNPAYLYCDTNAIPPP--DLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAG 1626
Query: 302 VYTCQAENGVGS--------LVSPPISL---HIFMAEVQVSPAGPILENQTVTLVCNT-P 349
Y+C+A N VG +++PP+ L + EV V+ + TV+L C
Sbjct: 1627 RYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS------TVSLQCPALG 1680
Query: 350 NEAPSDLRYSWYKNHV---------LLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSER 400
N P+ SW +N + +LED L++ A AD Y C +N GS
Sbjct: 1681 NPVPT---ISWLQNGLPFSPSPRLQVLEDGQ--VLQVSTAEVADAASYMCVAENQAGSAE 1735
Query: 401 SGPVSVVVNHPPLTPVL-----TAFLETQAGLVGILHCSVVSEPL---ATLVLSHGGHIL 452
++ V PP L TA L + L +H E + LS G +
Sbjct: 1736 K-LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVF 1794
Query: 453 ASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR 512
P + L++ +DSG Y C A N+ G +
Sbjct: 1795 LL----------------PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLS----- 1833
Query: 513 LLISPAAE-----------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP----- 556
+L+ PA V G LSC + P P +WY +G L
Sbjct: 1834 VLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTV--TWYKDGQPLVLAQRTQAL 1891
Query: 557 --GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGA 614
G L + A +D G Y C+ + A LTV PP T AG+
Sbjct: 1892 RGGQRLEIQEAQVSDKGLYSCKV--SNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGS 1949
Query: 615 GAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRV 674
+L C V P + L KDR+ S G S G R+
Sbjct: 1950 PL----VLTCDVSGVPAPTVTWL-KDRMPVESSAVHGVVSRGG---------------RL 1989
Query: 675 EIHNPLLEEEGLYLCEASNALGNAS----TSATFNGQATVLAIAPSHTLQEGTEANLTCN 730
++ + G Y C A N A + + +A H + EG E L C
Sbjct: 1990 QLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC- 2048
Query: 731 VSREAAGSPA-NFSWFRNGVLWAQ--GPL-------ETVTLLPVARTDAALYACRILTEA 780
EA G P + +W ++G Q GP ++ L + +DA Y C A
Sbjct: 2049 ---EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPA 2105
Query: 781 G--AQLSTPVLLSVLYPPDRPKL---SALLDMGQGHMALFICTV-DSRPLALLALFHGEH 834
G A+L T ++VL PP + S L G + +C V S P+ + L G
Sbjct: 2106 GEDARLHT---VNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDG-- 2160
Query: 835 LLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894
L L + HG + L + ++ L D+G + C A + G ++ + QV
Sbjct: 2161 -LPLPLSQRTLLHG--------SGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV- 2210
Query: 895 GAWVQVSPSPELQE---------GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST---S 942
QV P E E G V L C+ GVP W +DG+PL +
Sbjct: 2211 ----QVPPVLEPVEFQNDVVVVRGSLVELPCEAR-GVPLPL-VSWMKDGEPLLSQSLEQG 2264
Query: 943 ATLRFAAITLTQAGAYHCQA-----QAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP 997
+L+ A+ +G Y C A +A ++ P + S P ++LT P
Sbjct: 2265 PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLT------P 2318
Query: 998 GRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGA 1057
G LLC P + H D + L+ + + A LR+
Sbjct: 2319 GAPMELLCDAQGTPQPNITW-HKDGQALTRLE------------NNSRATRVLRVR---- 2361
Query: 1058 MLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGAT-----VREGQLVNLTCLVWTT 1112
D G+Y C A + G S QA V P + GQLV L C V
Sbjct: 2362 ---DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSV-EA 2416
Query: 1113 HPAQLTYTWYQDG-QQRLDAHS--------IPLPNVTVRDATSYRC----GVGPPGRAPR 1159
PA TW++DG + DAH+ + L ++ D+ Y C G A R
Sbjct: 2417 EPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2475
Query: 1160 LSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGR--LLASSTA 1217
+ + P + ++ Q AL+ C D PA L R L S
Sbjct: 2476 VEIHTVPTIRSGPPAVNVSV------NQTALLPCQADG-VPAPLVSWRKDRVPLDPRSPR 2528
Query: 1218 ASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPI 1277
+ L ++ +D G Y C A + G +LR +L P A P + +
Sbjct: 2529 FEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR------VLEPPAIAPSPSNL 2582
Query: 1278 TVTCADPA-------AHAPTLYTWYHNGRWL----QEG-----PAASLSFLVATRAHAGA 1321
T+T PA L W+ +G+ L Q+G P+ +L +
Sbjct: 2583 TLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQ 2642
Query: 1322 YSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMA--VIQCTVDSEPPAELAL 1379
+ C + G QV + D MA V+ C P ++
Sbjct: 2643 FECVVSNEVGEAHR---LYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSW 2699
Query: 1380 SHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGR 1439
S G L A G+G+ AL + Q +P Y C+A+N G
Sbjct: 2700 SKAGAQLG--------ARGSGYRVSPSGALEIG-QALPIHAGRYTCSARNSAGVAHKHVF 2750
Query: 1440 LQVEGARVVAEPGLDVPEGAA---LNLSCRLLGGPGPVGNSTFAWFWNDRRL------HA 1490
L V+ + VV +P V A + L C G P P T W +
Sbjct: 2751 LTVQASPVV-KPLPSVVRAVAEEEVLLPCEASGIPRP----TITWQKEGLNVATGVSTQV 2805
Query: 1491 EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRG 1550
P L H + AG Y C+A+ G+A L V PP + + G
Sbjct: 2806 LPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGK-TRLVVQVPPVIENGLPDLSTTEGSHA 2864
Query: 1551 ILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGE 1610
L C+ P ++T + V+ AE + S L ++ L D G
Sbjct: 2865 FLPCKARGSPEPNITWDKDGQPVSG-------AEGKFTIQPSGELL---VKNLEGQDAGT 2914
Query: 1611 YICSASNVLGSASTSTYFGVRAL 1633
Y C+A N +G A + + L
Sbjct: 2915 YTCTAENAVGRARRRVHLTILVL 2937
Score = 124 bits (311), Expect = 8e-28
Identities = 263/1141 (23%), Positives = 402/1141 (35%), Gaps = 168/1141 (14%)
Query: 188 SQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSP 247
SQ+ G GH TL ++ I C + A LQV+ P +L
Sbjct: 2166 SQRTLLHGSGH--TLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPP----VLEPV 2219
Query: 248 SGRN---ILPGELVTLTCQVNS-SYPAVSSIKWLKDGVRLQTKT----GVLHLPQAAWSD 299
+N ++ G LV L C+ P VS W+KDG L +++ L L D
Sbjct: 2220 EFQNDVVVVRGSLVELPCEARGVPLPLVS---WMKDGEPLLSQSLEQGPSLQLEAVGAGD 2276
Query: 300 AGVYTCQAENGVG--------SLVSPPISLHIFMA----EVQVSPAGPILENQTVTLVCN 347
+G Y+C A + G +++ PP HI + E+ ++P P+ L+C+
Sbjct: 2277 SGTYSCVAVSEAGEARRHFQLTVMEPP---HIEDSGQPTELSLTPGAPM------ELLCD 2327
Query: 348 TPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGS-ERSGPVSV 406
++ +W+K+ L +++ + D G Y C ++ G+ E+S V V
Sbjct: 2328 AQGTPQPNI--TWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRV 2385
Query: 407 VVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466
+ P F+ A +L CSV +EP + G +L +
Sbjct: 2386 QAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAH--------- 2436
Query: 467 GTSGPNSLR-LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLIS--PAAEVVE 523
T P R L+++ L DSG+Y C+A N+ G+ + + + S PA V
Sbjct: 2437 -TQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSV 2495
Query: 524 GQAVTLSCRSGLSPTPDARFSWYLNGALLHEG-------PGSSLLLPAASSTDAGSYHCR 576
Q L C++ P P SW + L P SL + + DAG Y C
Sbjct: 2496 NQTALLPCQADGVPAP--LVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCL 2553
Query: 577 ARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQL 636
A +SA L VL PP + L L A LL C P +
Sbjct: 2554 A--SNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPA-----LLPCEASGSPKPLVVW 2606
Query: 637 LHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG 696
+ + L G ++ + LL + P ++ + C SN +G
Sbjct: 2607 WKDGQKLDFRLQQGA-----------YRLLPSNALL---LTAPGPQDSAQFECVVSNEVG 2652
Query: 697 NAST--SATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNGV---- 749
A T + T+ T+ LTC+ + G PA SW + G
Sbjct: 2653 EAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCH----STGIPAPTVSWSKAGAQLGA 2708
Query: 750 ------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSA 803
+ G LE LP+ A Y C AG V L+V P L +
Sbjct: 2709 RGSGYRVSPSGALEIGQALPI---HAGRYTCSARNSAGVA-HKHVFLTVQASPVVKPLPS 2764
Query: 804 LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
++ L C P + +AT + QV G+ L +
Sbjct: 2765 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ-----------LRI 2813
Query: 864 RELGLGDSGSYRCEATNVLGSS--NTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTG 921
D+G+Y C A N GS+ T L QV P EG L C+ G
Sbjct: 2814 AHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKAR-G 2872
Query: 922 VPEGTSYRWYRDGQPLQEST-------SATLRFAAITLTQAGAYHCQAQAPGSATTSLAA 974
PE + W +DGQP+ + S L + AG Y C A+ +A
Sbjct: 2873 SPE-PNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAE---NAVGRARR 2928
Query: 975 PISLHVSYAPRHVTLTTLMDTGPGRLG---LLLCRVDSDPPAQLRLLHGDRLVASTLQGV 1031
+ L + P TTL RLG L C P ++ DR V +GV
Sbjct: 2929 RVHLTILVLP---VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT---EGV 2982
Query: 1032 GGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF---DAQAVN 1088
+G S AV+ ED G Y+C A N +G+ A + +A +
Sbjct: 2983 SEQDGGSTLQRAAVSR------------EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQ 3030
Query: 1089 VQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDG--------QQRLDAHSIPLPNVT 1140
+ + G + L C+V + W +DG + +L S+ +
Sbjct: 3031 GEAFSYLVEPVGGSIQLDCVVRGDPVPDIH--WIKDGLPLRGSHLRHQLQNGSLTIHRTE 3088
Query: 1141 VRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRP 1199
DA Y+C G A ++ + L + AP + G + C P
Sbjct: 3089 RDDAGRYQCLAENEMGVAKKV---VILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEP 3145
Query: 1200 PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE 1259
+ AG+ L +S L L + D G Y C A + LG A L +
Sbjct: 3146 TPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3205
Query: 1260 G 1260
G
Sbjct: 3206 G 3206
Score = 73.9 bits (180), Expect = 1e-12
Identities = 192/856 (22%), Positives = 301/856 (35%), Gaps = 132/856 (15%)
Query: 842 PQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGA---W- 897
P +P Q + + L++ +G D G Y+C A + G +V W
Sbjct: 257 PVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSPAGQQARDFQLRVHAPPTIWG 314
Query: 898 VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT-------LRFAAI 950
+ + E V L C+ GVP + W++DG L ST L+
Sbjct: 315 SNETGEVAVMEDHLVQLLCEAR-GVPT-PNITWFKDGALLPTSTKVVYTRGGRQLQLGRA 372
Query: 951 TLTQAGAYHCQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDS 1009
+ AG Y C+A A G+A + + Y P + G G ++ V
Sbjct: 373 QSSDAGVYTCKASNAVGAAEKATRLDV-----YVPPTIE-------GAGGRPYVVKAVAG 420
Query: 1010 DPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA 1069
P A + G + G P S + + LRLE G G+Y C A
Sbjct: 421 RPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEA--SSGLYSCVA 478
Query: 1070 SNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQL----------TY 1119
S+ G+A +V VQV P V EG L +T +V P +L T
Sbjct: 479 SSPAGEAVLQ-----YSVEVQVPPQLLVAEG-LGQVTTIVG--QPLELPCQASGSPVPTI 530
Query: 1120 TWYQDG---------QQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLY 1170
W Q+G Q ++ + +V + + + C +++ +
Sbjct: 531 QWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEW 590
Query: 1171 APRNLRLT-----YLLESHGGQLALVLCTVDS------RPPAQLALSHAGRLLASSTAAS 1219
AP L + + E H A V +PP G L T
Sbjct: 591 APGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIP 650
Query: 1220 VPNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEA-------A 1270
V +L L++ RDEG Y+C+A + G++ + L+ V++ P A
Sbjct: 651 VAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALK-----VLVPPNIEPGPVNKA 705
Query: 1271 VPEGAPITVTCADPAAHAPTLYTWYHNGR----WLQEGPAASLSFLV-----ATRAHAGA 1321
V E A +T+ C P + +W+ + W+ G S+ V A + AG+
Sbjct: 706 VLENASVTLECLASGVPPPDV-SWFKGHQPVSSWM--GVTVSVDGRVLRIEQAQLSDAGS 762
Query: 1322 YSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV-IQCTVDSEPPAELALS 1380
Y C A + G+ R L+V P+ + S + V + C P L
Sbjct: 763 YRCVASNVAGSTELR-YGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWL 821
Query: 1381 HDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGR 1439
DG ++ + GT +QV L + A D Y C A + +G
Sbjct: 822 KDGNPVSPA--------GTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV 873
Query: 1440 LQVEGARVVA--EPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTL- 1496
LQV + E + V ++ L C+ P PV +W+ + R L P L
Sbjct: 874 LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV----LSWWKDGRPLEPRPGVHLS 929
Query: 1497 ---AFTHVARAQ---AGMYHCLAELPTGAAA---SAPVMLRVLYPPKTPTMMVFVEPEGG 1547
A V RA AG Y C A G + + V + ++P + + E G
Sbjct: 930 ADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVRE---G 986
Query: 1548 LRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSD 1607
L C P ++ QP HV A L + L +
Sbjct: 987 HPTSLSCECRGVPFPKISWR------KDGQPLPGEGAGLQHVSAVGRLLYLGQAQL--AQ 1038
Query: 1608 QGEYICSASNVLGSAS 1623
+G Y C SNV+G++S
Sbjct: 1039 EGTYTCECSNVVGNSS 1054
Score = 64.7 bits (156), Expect = 7e-10
Identities = 141/589 (23%), Positives = 199/589 (33%), Gaps = 96/589 (16%)
Query: 1100 GQLVNLTCLVWTTHPAQLTYTWYQDGQQRL----------DAHSIPLPNVTVRDATSYRC 1149
G V L C WT+ W +D Q L D + + V D Y+C
Sbjct: 232 GADVELQC--WTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQC 289
Query: 1150 GVGPPGRAPRLSRPITLDV-----LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLA 1204
P A + +R L V ++ ++E H L +LC P +
Sbjct: 290 VAFSP--AGQQARDFQLRVHAPPTIWGSNETGEVAVMEDH---LVQLLCEARGVPTPNIT 344
Query: 1205 LSHAGRLLASSTAASVPNTLR-LELRGPQPRDEGFYSCSARSPLGQANTSLELRL----- 1258
G LL +ST R L+L Q D G Y+C A + +G A + L +
Sbjct: 345 WFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT 404
Query: 1259 ---EGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVAT 1315
G R + A G P+ + C +PTL +W+H G + E + L +
Sbjct: 405 IEGAGGRPYVVKAVA---GRPVALECVARGHPSPTL-SWHHEGLPVAESNESRLETDGSV 460
Query: 1316 -------RAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCT 1368
A +G YSC A G + +++V PQ V Q T
Sbjct: 461 LRLESPGEASSGLYSCVASSPAG-EAVLQYSVEVQVPPQLLVAEGLG----------QVT 509
Query: 1369 VDSEPPAELALSHDGKVLATSSGVHS--LASGTGHVQVARNALRLQVQDVPAGDD-TYVC 1425
P EL G + T + + A VQVA L + V + C
Sbjct: 510 TIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFAC 569
Query: 1426 TAQNLLGSISTIGRLQVEGARVVAEPG-LDVPEG-------------AALNLSCRLLGGP 1471
A N G+ + V G PG L+VP G AA + G
Sbjct: 570 QATNEAGTAGAEVEVSVHGEWA---PGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGA 626
Query: 1472 GPVGNSTFAWFWNDRRLHAEPV---------PTLAFTHVARAQAGMYHCLAELPTGAAAS 1522
P W + L EP P L V G+Y C A G +
Sbjct: 627 HPKPPLVEGWC-SPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGES-K 684
Query: 1523 APVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAP 1582
V L+VL PP V L+C P ++ G + V+S
Sbjct: 685 REVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSS------- 737
Query: 1583 AEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
+ V S + + IE + SD G Y C ASNV G ST +G+R
Sbjct: 738 ---WMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG--STELRYGLR 781
Score = 47.4 bits (111), Expect = 1e-04
Identities = 82/328 (25%), Positives = 119/328 (36%), Gaps = 37/328 (11%)
Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159
LL+K+L+ +D+G+Y E + V T++ + P T+ L G +
Sbjct: 2902 LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL---PVFTTLPGDRSLRLGDRLWLR 2958
Query: 160 CSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQL 219
C+ R+ W D R VT E G L+ A+S +D G + C
Sbjct: 2959 CAARG---SPTPRIGWTVND--RPVTEGVS--EQDGGSTLQ--RAAVSREDSGTYV-CWA 3008
Query: 220 SVANHRAQSEIHLQVKYAP----KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIK 275
R Q+ + VK AP + L+ P G +I L C V V I
Sbjct: 3009 ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSI------QLDCVVRGD--PVPDIH 3060
Query: 276 WLKDGVRL-------QTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEV 328
W+KDG+ L Q + G L + + DAG Y C AEN +G I +
Sbjct: 3061 WIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVF 3120
Query: 329 QVSPAG-PILENQTVTLVCNTPNEAPSDLRYSWYKNHVL----LEDAHSHTLRLHLATRA 383
QV P + V L C E + + + L +L L
Sbjct: 3121 QVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETG 3180
Query: 384 DTGFYFCEVQNVHGSERSGPVSVVVNHP 411
D G Y C N+ GS + VV P
Sbjct: 3181 DAGTYDCVAHNLLGSATARAFLVVRGEP 3208
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 205 bits (522), Expect = 3e-52
Identities = 356/1491 (23%), Positives = 543/1491 (36%), Gaps = 255/1491 (17%)
Query: 259 TLTCQVNSSYPAVSSIKWLKDGV------RLQTKTG--VLHLPQAAWSDAGVYTCQAENG 310
T++ Q + V +I WL++G+ RLQ VL + A +DA Y C AEN
Sbjct: 2862 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ 2921
Query: 311 VGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLR------YSWYKNH 364
GS +F VQV P L+ + VT + N+ P D+ +WYK+
Sbjct: 2922 AGSAEK------LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDS 2975
Query: 365 VLLEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSERS-GPVSVVV----NHPP 412
L +HTL+L A +D+G Y CE N G ++ +SV+V P
Sbjct: 2976 QALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAP 3035
Query: 413 LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPN 472
P + + G +L C + P T+ G L R G
Sbjct: 3036 RGPQDAVLV--RVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQ-------RTQALRGGQ 3086
Query: 473 SLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE---GQAVTL 529
RLEI++ + +D G Y C +N G A T +P E V G + L
Sbjct: 3087 --RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVL 3144
Query: 530 SCRSGLSPTPDARFSWY-----LNGALLH--EGPGSSLLLPAASSTDAGSYHCRARDGHS 582
+C +S P +W + + +H G L L AG+Y C A + +
Sbjct: 3145 TC--DVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA 3202
Query: 583 ASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRV 642
+ V+ VL PR + + G+ L C D PP + L
Sbjct: 3203 EA--RKDFVVAVLVAPRIRSSGVAREHHVL---EGQEVRLDCEADGQPPPDVAWLKDGSP 3257
Query: 643 VATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSA 702
+ + GG S +K +A + G Y C A N G +
Sbjct: 3258 LGQDMGPHLRFYLDGG-SLVLKGLRA-------------SDAGAYTCVAHNPAGEDARLH 3303
Query: 703 TFNGQATVLAIAPSHTLQEGTEAN---------LTCNVSREAAGSPANFSWFRNGV---- 749
T N + + P T+++G + + L V P + SW ++G+
Sbjct: 3304 TVN-----VLVPP--TIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL 3356
Query: 750 ---LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLD 806
G T+ + V DA ++ C + AG L V PP + D
Sbjct: 3357 SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGV-ADRNFTLQVQVPPVLEPVEFQND 3415
Query: 807 --MGQGHMALFICTVDSRPLALLA-LFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
+ +G + C PL L++ + GE LL+ SL Q PS L++
Sbjct: 3416 VVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSL-EQGPS--------------LQL 3460
Query: 864 RELGLGDSGSYRCEATNVLGSSNTSLFFQV-RGAWVQVSPSP---ELQEGQAVVLSCQVH 919
+G GDSG+Y C A + G + V ++ S P L G + L C
Sbjct: 3461 EAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 3520
Query: 920 TGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSA-----TTSLAA 974
G P+ + W++DGQ L + + + + AG Y C A++P A + A
Sbjct: 3521 -GTPQ-PNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQA 3578
Query: 975 PISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034
P ++ PR V + PG+L +L C V+++P ++ H D +V
Sbjct: 3579 PPNIVGPRGPRFV-----VGLAPGQL-VLECSVEAEPAPKI-TWHRDGIVL--------- 3622
Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG 1094
H L++ D G Y C A N G S A V++
Sbjct: 3623 ---QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSV-------AFRVEIHTV 3672
Query: 1095 ATVREGQ-----LVNLTCLVWTTH---PAQLTYTWYQDGQ---------QRLDAHSIPLP 1137
T+R G VN T L+ PA L +W +D + L S+ +
Sbjct: 3673 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLV-SWRKDRVPLDPRSPRFEILPEGSLRIQ 3731
Query: 1138 NVTVRDATSYRC------GVGPPGRAPRLSRPITLDVLYAPRNLRLT------YLLESHG 1185
V +DA Y C G GR R+ P + +P NL LT E+ G
Sbjct: 3732 PVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPA--IAPSPSNLTLTAHTPALLPCEASG 3789
Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARS 1245
LV+ D + A RLL S+ L L P P+D + C +
Sbjct: 3790 SPKPLVVWWKDGQKLDFRLQQGAYRLLPSNA---------LLLTAPGPQDSAQFECVVSN 3840
Query: 1246 PLGQANTSLELRLEGVRVILAPEAA-------VPEGAPITVTCADPAAHAPTLYTWYHNG 1298
+G+A+ RL V V + P A V AP+ +TC APT+ +W G
Sbjct: 3841 EVGEAH-----RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTV-SWSKAG 3894
Query: 1299 RWL-------QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVL 1351
L + P+ +L A HAG Y+C A+++ G + + L V +P L
Sbjct: 3895 AQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPL 3953
Query: 1352 SSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRL 1411
S + A ++ C P + +G +AT GV + G +++A +
Sbjct: 3954 PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVAT--GVSTQVLPGGQLRIAHAS--- 4008
Query: 1412 QVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAE--PGLDVPEGAALNLSCRLLG 1469
P Y+C A+N GS RL V+ V+ P L EG+ L C+ G
Sbjct: 4009 -----PEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARG 4063
Query: 1470 GPGPVGNSTFAWFWN---------DRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAA 1520
P P N T W+ + + +P L ++ AG Y C AE G A
Sbjct: 4064 SPEP--NIT----WDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRA 4117
Query: 1521 ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQG 1580
V L +L P T+ G R L C P + + R V
Sbjct: 4118 RRR-VHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG---- 4172
Query: 1581 APAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
V + A+ D G Y+C A N +G ++ V+
Sbjct: 4173 --------VSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 4215
Score = 202 bits (513), Expect = 3e-51
Identities = 373/1573 (23%), Positives = 580/1573 (36%), Gaps = 263/1573 (16%)
Query: 194 TGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNIL 253
+ VG L L A Q+ C V N + ++ L+V P+ P+ +++
Sbjct: 2214 SAVGRLLYLGQAQLAQEGTYTCECSNVVGN--SSQDLQLEVHVPPQIAGPREPPTQVSVV 2271
Query: 254 PGELVTLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTC 305
+ TL C P ++ W +DG ++LQ + LH+ +A + G Y+C
Sbjct: 2272 QDGVATLECNATGKPPP--TVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 2329
Query: 306 QAENGVGSLVSPPISLHIFMAEVQVSPAGPILE-----NQTVTLVCNTPNEAPSDLRYSW 360
AEN G L + + + P+ + +TL+C P +R W
Sbjct: 2330 VAENLAGR-AERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIR--W 2386
Query: 361 YKNHVLL---EDAH----SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413
++ + ED + L++ D+G Y C N G R SV V PP
Sbjct: 2387 FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRN-FSVEVLVPPS 2445
Query: 414 --TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGP 471
L ++ G L C+V P L G LA GD+ H P
Sbjct: 2446 IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR--GDAHHI-------SP 2496
Query: 472 NSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAE-------VVEG 524
+ + L++ + +G Y C A N++G T A ++ A + V
Sbjct: 2497 DGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVN 2556
Query: 525 QAVTLSCRSGLSPTPDARFSWYLNGALLHEG------PGS-SLLLPAASSTDAGSYHCRA 577
++L C + P+P+ +W +GA PG+ L + A DAG Y C
Sbjct: 2557 NPISLICEALAFPSPN--ITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVV 2614
Query: 578 RDGHSASGPSSPAVLTVLYPPR--QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635
+ + + + VL PP + + + L C + PP ++
Sbjct: 2615 TNELGEAVKNYH--VEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIR 2672
Query: 636 LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695
+KD T S R++V LL+++ + + G YLC A+N
Sbjct: 2673 W-YKDGQPVTP-------------SSRLQVLGEGRLLQIQPTQ--VSDSGRYLCVATNVA 2716
Query: 696 GNASTS--------------ATFNGQATVLA--------IAPSHTLQEGTEANLTCNVSR 733
G F+ +L+ + + E A L C+ +
Sbjct: 2717 GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTN- 2775
Query: 734 EAAGSPANFSWFRNGVLWAQGPLETVTL------LPVARTD-AALYACRILTEAGAQLST 786
A P + +W+R + G +V +P+ R + A Y+C+ E G
Sbjct: 2776 --AIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 2833
Query: 787 PVLLSVLYPP----DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGP 842
LL VL PP D +L + + C P+ ++ + S
Sbjct: 2834 YELL-VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRL 2892
Query: 843 QVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSP 902
QV G+ L+V + D+ SY C A N GS+ F +R VQV P
Sbjct: 2893 QVLEDGQV----------LQVSTAEVADAASYMCVAENQAGSAEK--LFTLR---VQVPP 2937
Query: 903 ---SPELQEGQAVV-----LSCQVHTGV-PEGTSYRWYRDGQPLQESTSA-------TLR 946
+L++ A++ L C VH PE T WY+D Q L TL+
Sbjct: 2938 RIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT---WYKDSQALSLGEEVFLLPGTHTLQ 2994
Query: 947 FAAITLTQAGAYHCQA-QAPG--SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLL 1003
L+ +G Y C+A A G L+ + APR L+ G +L
Sbjct: 2995 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDK--AVL 3052
Query: 1004 LCRVDSDP-PAQLRLLHGDRLV-ASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061
C D+ P P G LV A Q + G + RLEI A + D
Sbjct: 3053 SCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ---------------RLEIQEAQVSD 3097
Query: 1062 EGVYICEASNTLGQASASADFDAQAVNVQVWPGA-TVRE--GQLVNLTCLVWTTHPAQLT 1118
+G+Y C+ SN G+A + Q P TV + G + LTC V + PA T
Sbjct: 3098 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAP-T 3155
Query: 1119 YTWYQDGQQRLDAHSIPLPNVTVR------------DATSYRCGVGPPGRAPRLSRPITL 1166
TW +D R+ S + V R A +Y C R + +
Sbjct: 3156 VTWLKD---RMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR--KDFVV 3210
Query: 1167 DVLYAPRNLRLTYLLESH---GGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT 1223
VL APR +R + + H GQ + C D +PP +A G L +
Sbjct: 3211 AVLVAPR-IRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY 3269
Query: 1224 L---RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP---EAAVPEGAPI 1277
L L L+G + D G Y+C A +P G+ + RL V V++ P + A G +
Sbjct: 3270 LDGGSLVLKGLRASDAGAYTCVAHNPAGE-----DARLHTVNVLVPPTIKQGADGSGTLV 3324
Query: 1278 T-----VTCADPAAHAPTLY-TWYHNG-------RWLQEGPAASLSFLVATRAHAGAYSC 1324
+ VT P +P ++ +W +G R L G +L A AG ++C
Sbjct: 3325 SRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC 3384
Query: 1325 QAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRA--RSMAVIQCTVDSEPPAELALSHD 1382
A G + R LQV P + D S+ + C P ++ D
Sbjct: 3385 VAASPAGV-ADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD 3443
Query: 1383 GKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQ 1441
G+ L + SL G LQ++ V AGD TY C A + G +L
Sbjct: 3444 GEPLLS----QSLEQGPS----------LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 3489
Query: 1442 VEGARVVAEPG----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLA 1497
V + + G L + GA + L C G P P W + + L + A
Sbjct: 3490 VMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQP----NITWHKDGQALTRLENNSRA 3545
Query: 1498 FTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYP-----PKTPTMMVFVEPEGGLRGIL 1552
+ AG+Y CLAE P GA + +RV P P+ P +V + P G L +L
Sbjct: 3546 TRVLRVRDAGLYTCLAESPAGAIEKS-FRVRVQAPPNIVGPRGPRFVVGLAP-GQL--VL 3601
Query: 1553 DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612
+C V++EP +T H G + H + ++AL +D G+Y
Sbjct: 3602 ECSVEAEPAPKITWH----------RDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYS 3651
Query: 1613 CSASNVLGSASTS 1625
C+A N GS S +
Sbjct: 3652 CTARNAAGSTSVA 3664
Score = 201 bits (510), Expect = 7e-51
Identities = 379/1557 (24%), Positives = 563/1557 (36%), Gaps = 298/1557 (19%)
Query: 258 VTLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTCQAEN 309
V+L C V++ +P + W KD V L T L L +A SD+G+YTC+A N
Sbjct: 2955 VSLPCDVHA-HPN-PEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALN 3012
Query: 310 GVG---SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVL 366
G LV + + + P +L V + +A + +WYK+
Sbjct: 3013 AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQP 3072
Query: 367 LEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPP-LTPVLT 418
L A L + A +D G Y C+V NV G E ++ V PP T
Sbjct: 3073 LVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKT 3131
Query: 419 AFLETQAGLVGILHCSVVSEPLATL--------VLSHGGHILASTSGDSDHSPRFSGTSG 470
+ AG +L C V P T+ V S H + S G
Sbjct: 3132 ETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGG------------- 3178
Query: 471 PNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN---AARLLISPAAE---VVEG 524
RL++ L+ +G Y C A N+ A DF A R+ S A V+EG
Sbjct: 3179 ----RLQLSRLQPAQAGTYTCVAENTQAEARK--DFVVAVLVAPRIRSSGVAREHHVLEG 3232
Query: 525 QAVTLSCRSGLSPTPDARFSWYLNGALLHE--GP-------GSSLLLPAASSTDAGSYHC 575
Q V L C + P PD +W +G+ L + GP G SL+L ++DAG+Y C
Sbjct: 3233 QEVRLDCEADGQPPPDV--AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 3290
Query: 576 RARDGHSASGPSSPA-VLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLL---CRVDSDPP 631
A H+ +G + + VL PP T + D +G R G L+ C V PP
Sbjct: 3291 VA---HNPAGEDARLHTVNVLVPP-----TIKQGADGSGTLVSRPGELVTMVCPVRGSPP 3342
Query: 632 ARLQLL------------------HKDRVVATSLPSGGGCSTCGGCSPR--------MKV 665
+ L H R+ L + G TC SP ++V
Sbjct: 3343 IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQL-ADAGIFTCVAASPAGVADRNFTLQV 3401
Query: 666 TKAPNLLRVEIHNPLLEEEGLYL---CEASN----------------------------- 693
P L VE N ++ G + CEA
Sbjct: 3402 QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLE 3461
Query: 694 ALGNASTSATFN-------GQAT----VLAIAPSHTLQEG--TEANLTCNVSRE----AA 736
A+G A S T++ G+A + + P H G TE +LT E A
Sbjct: 3462 AVG-AGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 3520
Query: 737 GSPA-NFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP 795
G+P N +W ++G + + + DA LY C + AGA + + V P
Sbjct: 3521 GTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGA-IEKSFRVRVQAP 3579
Query: 796 PD-----RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRF 850
P+ P+ L GQ + C+V++ P + +L Q P GRF
Sbjct: 3580 PNIVGPRGPRFVVGLAPGQ---LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF 3636
Query: 851 QAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV----SPSPEL 906
L+++ L DSG Y C A N GS TS+ F+V V P+ +
Sbjct: 3637 ----------LQLQALSTADSGDYSCTARNAAGS--TSVAFRVEIHTVPTIRSGPPAVNV 3684
Query: 907 QEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST-------SATLRFAAITLTQAGAYH 959
Q +L CQ GVP W +D PL + +LR + AG Y
Sbjct: 3685 SVNQTALLPCQAD-GVP-APLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL 3742
Query: 960 CQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDP-PAQLRL 1017
C A + GS + + AP LT T LL C P P +
Sbjct: 3743 CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTP----ALLPCEASGSPKPLVVWW 3798
Query: 1018 LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQAS 1077
G +L QG S+ L A P +D + C SN +G+A
Sbjct: 3799 KDGQKLDFRLQQGAYRLLPSNALLLTAPGP------------QDSAQFECVVSNEVGEAH 3846
Query: 1078 ASADFDAQAVNVQVWPGATVREGQ----LVNLTCLVWTTHPAQL---TYTWYQDGQQRLD 1130
V V V P T+ + Q + + +V T H + T +W + G Q L
Sbjct: 3847 R-----LYQVTVHVPP--TIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ-LG 3898
Query: 1131 AHSIPLPNVTVRDATSYRCGVGPPGRAPRLS-----------RPITLDVLYAPRNLRLTY 1179
A V + + G P A R + + + L V +P L
Sbjct: 3899 ARG---SGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPS 3955
Query: 1180 LLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFY 1239
++ + + L+ C P + G +A+ + V +L + P D G Y
Sbjct: 3956 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNY 4015
Query: 1240 SCSARSPLGQA--NTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN 1297
C A++ G A T L +++ V P+ + EG+ + C + P + TW +
Sbjct: 4016 LCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNI-TWDKD 4074
Query: 1298 GRWLQ--EG-----PAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAV 1350
G+ + EG P+ L AG Y+C A++A G R+ R L +L P
Sbjct: 4075 GQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG-RARRRVHLTILVLPVFTT 4133
Query: 1351 LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR 1410
L R R ++C P + + + + + S V+R
Sbjct: 4134 LPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSRE--- 4190
Query: 1411 LQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV---AEPGLDVPEGAALNLSCRL 1467
TYVC A+N +G + + V+ A V+ A L P G ++ L C +
Sbjct: 4191 --------DSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV 4242
Query: 1468 LGGPGPVGNSTFAWFWNDRRL------HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAA 1521
G P P W + L H +L R AG Y CLAE G A
Sbjct: 4243 RGDPVP----DIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAK 4298
Query: 1522 SAPVMLRVLYPPKTPTMMVF-VEPE-----GGLRGILDCRVDSEPLASLT-LHLGSRLVA 1574
+++ P VF VEP+ G L C+ EP ++ L G L A
Sbjct: 4299 KVVILVLQSAP-------VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRA 4351
Query: 1575 SSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
S + + P + +E + D G Y C A N+LGSA+ + VR
Sbjct: 4352 SRRLRTLPDGS------------LWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 4396
Score = 199 bits (507), Expect = 1e-50
Identities = 379/1600 (23%), Positives = 553/1600 (34%), Gaps = 312/1600 (19%)
Query: 210 DHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYP 269
D GR +C S AN ++ + L V+ AP+ + + S ++ G V ++C S YP
Sbjct: 581 DGGRY-QCVASNANGVTRASVWLLVREAPQ---VSIHTSSQHFSQGVEVKVSCSA-SGYP 635
Query: 270 AVSSIKWLKDGVRLQTKT-------GVLHLPQAAWSDAGVYTCQAENGVGS-------LV 315
I W ++ LQ + G L + A DAG Y+CQA N VG+
Sbjct: 636 T-PHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY 694
Query: 316 SPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLL----EDAH 371
+ P S+ A V V+ + LVC P R WY+ + + E +
Sbjct: 695 TDPPSVSAVNAVVLVAVG------EEAVLVCEASGVPPP--RVIWYRGGLEMILAPEGSS 746
Query: 372 SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGIL 431
S LR+ A D G Y C N G + S + + V H P L + + G +L
Sbjct: 747 SGKLRIPAAQERDAGTYTCRAVNELG-DASAEIQLAVGHAPQLTELPRDVTVELGRSALL 805
Query: 432 HCSVVSEPLATLVLSHG-GHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYK 490
C P T+ G G L G + R S + P+S L + D Y
Sbjct: 806 ACRATGRPPPTVTWRRGDGQPLGLRLG----AGRGSRSRQPDSGVLFFESVAPEDQAPYV 861
Query: 491 CSATNSLGN----ATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWY 546
C A N G A + HA +P V+EGQ V+L C L+ P W
Sbjct: 862 CEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIV-LAGRPLPERHWL 920
Query: 547 LNGALLHEGP------GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPR- 599
+G L G SL L A AG Y C A + +A L V PPR
Sbjct: 921 KDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATN--TAGSQHRDVELVVQVPPRI 978
Query: 600 QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGC 659
PT T + + A L C V S PA K+ TS
Sbjct: 979 HPTATHHITNEGVPAS------LPC-VASGVPAPTITWTKETNALTSR------------ 1019
Query: 660 SPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLA------- 712
P V+K LL I P ++ G Y+C A+N +G +S + L+
Sbjct: 1020 GPHYNVSKEGTLL---IAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEY 1076
Query: 713 -IAPSHTL-----QEGTEANLTCNVSREAA------------------------------ 736
+ PS +L Q G + C S A
Sbjct: 1077 GLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEA 1136
Query: 737 --------GSP-ANFSWFRNG-VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLST 786
G+P SW ++G VL +GP +V + +DA Y C AG +
Sbjct: 1137 LDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVD-AW 1195
Query: 787 PVLLSVLYPP--DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQV 844
V L VL PP + S LL+ G A C P + G
Sbjct: 1196 EVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGP--------SSE 1247
Query: 845 PSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSP 904
P HG+ A L + + DSG Y C+ATN +GS++ R A + V P
Sbjct: 1248 PLHGQ-PGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTS-------RRAKLVVYVPP 1299
Query: 905 ELQE-----------GQAVVLSCQVH---------------TGVP-----EGTSYRWYRD 933
++E GQ++ L C + GVP G W +
Sbjct: 1300 SIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQV 1359
Query: 934 GQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLM 993
G +L F I +G Y C+A+ A H+ +T +++
Sbjct: 1360 GGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG-----TAQRDFHLLV----LTPPSVL 1410
Query: 994 DTGPGR--LGL------LLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAV 1045
G + LGL L C P Q+ + V GGP H+ V
Sbjct: 1411 GAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLP-----GGP-------HLQV 1458
Query: 1046 APNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG-----ATVREG 1100
+ L I G+ + DEG Y C A + GQ + A +W V E
Sbjct: 1459 QEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT-IWGSNETGEVAVMED 1517
Query: 1101 QLVNLTCLVWTTHPAQLTYTWYQDGQ---------QRLDAHSIPLPNVTVRDATSYRC-- 1149
LV L C + TW++DG + L DA Y C
Sbjct: 1518 HLVQLLCEARGVPTPNI--TWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKA 1575
Query: 1150 --GVGPPGRAPRLSRPITLDVLYAPRNLR----LTYLLESHGGQLALVLCTVDSRPPAQL 1203
VG +A RL +Y P + Y++++ G+ + C P L
Sbjct: 1576 SNAVGAAEKATRLD-------VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTL 1628
Query: 1204 ALSHAGRLLASSTAASVP---NTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG 1260
+ H G +A S + + + LRLE P G YSC A SP G+A + ++
Sbjct: 1629 SWHHEGLPVAESNESRLETDGSVLRLE--SPGEASSGLYSCVASSPAGEAVLQYSVEVQV 1686
Query: 1261 VRVILAPE----AAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQE-------GPAASL 1309
+L E G P+ + C + PT+ W NGR +E +L
Sbjct: 1687 PPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTI-QWLQNGRPAEELAGVQVASQGTTL 1745
Query: 1310 SFLVATRAHAGAYSCQAQDAQGTRSSR----------PAALQVLYAPQDAVLSSFRDSRA 1359
H+G ++CQA + GT + P L+V A
Sbjct: 1746 HIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPA 1805
Query: 1360 RSMAVIQ--CTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVP 1417
+ +PP G + +G+ S +Q+ + LR
Sbjct: 1806 ACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLR------- 1858
Query: 1418 AGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPG---LDVPEGAALNLSCRLLGGPGPV 1474
+ Y C A NL G L+V + EPG V E A++ L C G P P
Sbjct: 1859 -DEGIYTCAATNLAGESKREVALKVLVPPNI-EPGPVNKAVLENASVTLECLASGVPPP- 1915
Query: 1475 GNSTFAWFWNDRRLHAEPVPTLA----FTHVARAQ---AGMYHCLA-------ELPTGAA 1520
+WF + + + T++ + +AQ AG Y C+A EL G
Sbjct: 1916 ---DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLR 1972
Query: 1521 ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQG 1580
+ P R+ PP P ++ P L C P +L + P
Sbjct: 1973 VNVPP--RITLPPSLPGPVLVNTPVR-----LTCNATGAPSPTL------MWLKDGNPVS 2019
Query: 1581 APAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620
P + V P + + + R SD G Y C A + +G
Sbjct: 2020 PAGTPGLQVF--PGGRVLTLASARASDSGRYSCVAVSAVG 2057
Score = 191 bits (485), Expect = 5e-48
Identities = 366/1491 (24%), Positives = 540/1491 (36%), Gaps = 263/1491 (17%)
Query: 270 AVSSIKWLKDGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQ 329
A+S W + G+ +G L L Q D+G Y C A N GS + H ++ VQ
Sbjct: 1067 ALSKYVWEEYGL---LPSGSLRLAQVQVGDSGHYECTASNPAGS------ASHRYVLGVQ 1117
Query: 330 VSPA---GP----ILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATR 382
V P GP +L + + L C E + + SW K+ V+L+ A R
Sbjct: 1118 VPPQVQPGPRVLKVLVGEALDLNCVA--EGNPEPQLSWSKDGVVLQGRGPQGSVHFAAIR 1175
Query: 383 -ADTGFYFCEVQNVHGSERSGPVSVVVNHPPL--TPVLTAFLETQAGLVGILHCSVVSEP 439
+D G Y CE N G + + V + V PP + LE AG L C P
Sbjct: 1176 TSDAGRYRCEASNSAGVD-AWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTP 1234
Query: 440 LATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGN 499
+ G S + H G + L + + DSG+Y+C ATN +G+
Sbjct: 1235 KPQVTWRKG------PSSEPLHGQ--PGVAVLEEGSLFLASVSPADSGDYECQATNEVGS 1286
Query: 500 ATSTLDFHANAARLLISPAAEVVE-----------GQAVTLSCRSGLSPTPD-------- 540
+ A+L++ + E GQ++TL C + P P+
Sbjct: 1287 T-------SRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQ 1339
Query: 541 --------ARFSWYLNGA------LLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGP 586
A + W L LL E G SL P D+G Y CRA + A
Sbjct: 1340 LVGVPLGWAGYGWDLGWGQVGGHRLLDE--GQSLHFPRIQEGDSGLYSCRAE--NQAGTA 1395
Query: 587 SSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVD-------SDPPARLQLLHK 639
L VL PP GAGA + L L D S P K
Sbjct: 1396 QRDFHLLVLTPP-----------SVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTK 1444
Query: 640 DRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNAS 699
DR LP G P ++V + +LR I + +EG Y C A + G +
Sbjct: 1445 DR--QPVLPGG----------PHLQVQEDGQVLR--ITGSHVGDEGRYQCVAFSPAGQQA 1490
Query: 700 TSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNG--------VL 750
A + T + + + EA G P N +WF++G V+
Sbjct: 1491 RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVV 1550
Query: 751 WAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQG 810
+ +G + + L +DA +Y C+ GA L V PP G G
Sbjct: 1551 YTRGGRQ-LQLGRAQSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIE--------GAG 1600
Query: 811 HMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLE-------V 863
+ V RP+AL + G P + H AE+N +LE +
Sbjct: 1601 GRPYVVKAVAGRPVALECVARGHP------SPTLSWHHEGLPVAESNESRLETDGSVLRL 1654
Query: 864 RELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE---------GQAVVL 914
G SG Y C A++ G + L + V VQV P + E GQ + L
Sbjct: 1655 ESPGEASSGLYSCVASSPAGEA--VLQYSVE---VQVPPQLLVAEGLGQVTTIVGQPLEL 1709
Query: 915 SCQVHTGVPEGTSYRWYRDGQPLQE-------STSATLRFAAITLTQAGAYHCQAQAPGS 967
CQ +G P T +W ++G+P +E S TL + L +G + CQA +
Sbjct: 1710 PCQA-SGSPVPT-IQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA-TNEA 1766
Query: 968 ATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRL-LHGDRLVAS 1026
T +S+H +AP V + G DPP H +
Sbjct: 1767 GTAGAEVEVSVHGEWAP-GVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVE 1825
Query: 1027 TLQGVGGPEGSSPRLHVAVA-PNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQ 1085
G G + VA + P L++E L DEG+Y C A+N G++
Sbjct: 1826 GWCSPGSLWGEPTGIPVAYSLPPPLQIE--KVDLRDEGIYTCAATNLAGESKREVALKVL 1883
Query: 1086 A-VNVQVWP-GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ---------RLDAHSI 1134
N++ P V E V L CL P + +W++ Q +D +
Sbjct: 1884 VPPNIEPGPVNKAVLENASVTLECLASGVPPPDV--SWFKGHQPVSSWMGVTVSVDGRVL 1941
Query: 1135 PLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV---LYAPRNLRLTYLLESHGGQLALV 1191
+ + DA SYRC + L + ++V + P +L L+ + +
Sbjct: 1942 RIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP----VRL 1997
Query: 1192 LCTVDSRPPAQLALSHAGRLLASSTAASV---PNTLRLELRGPQPRDEGFYSCSARSPLG 1248
C P L G ++ + + P L L + D G YSC A S +G
Sbjct: 1998 TCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG 2057
Query: 1249 QANTSLELRLEGVRVILAPE--AAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPA 1306
+ + L++ IL E +V + + C A P L +W+ +GR L+ P
Sbjct: 2058 EDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVL-SWWKDGRPLEPRPG 2116
Query: 1307 ASLS----FLVATRA---HAGAYSCQAQDAQGTRSSRPAALQVLYAP----QDAVLSSFR 1355
LS L RA AG Y+C+A + G S + L V AP +++ + R
Sbjct: 2117 VHLSADKALLQVDRADVWDAGHYTCEALNQAG-HSEKHYNLNVWVAPVFPLRESHTLTVR 2175
Query: 1356 DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQD 1415
+ S++ C P +++ DG+ L +G HV L L Q
Sbjct: 2176 EGHPTSLS---CECRGVPFPKISWRKDGQPLPGE------GAGLQHVSAVGRLLYLG-QA 2225
Query: 1416 VPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEP-----GLDVPEGAALNLSCRLLGG 1470
A + TY C N++G+ S +L+V +A P + V + L C G
Sbjct: 2226 QLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGK 2285
Query: 1471 PGPVGNSTFAWFWNDRRLHAEPVPTL----AFTHVARAQA---GMYHCLAELPTGAAASA 1523
P P T W + + + AE L HV RAQA G Y C+AE G A
Sbjct: 2286 PPP----TVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG-RAER 2340
Query: 1524 PVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQG--- 1580
L VL PP+ L G LD PL ++T L S L + G
Sbjct: 2341 KFELSVLVPPE-------------LIGDLD------PLTNITAALHSPLTLLCEAMGIPP 2381
Query: 1581 ---------APAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
P P + + + D G Y C ASN G A
Sbjct: 2382 PAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEA 2432
Score = 179 bits (454), Expect = 2e-44
Identities = 398/1681 (23%), Positives = 604/1681 (35%), Gaps = 297/1681 (17%)
Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRV---PTIASPVELLEGTEV 156
L ++ Q D+GSY R S V ++++ L V PR+ P++ PV L T V
Sbjct: 1941 LRIEQAQLSDAGSY--RCVASNVAGSTELRYGL-RVNVPPRITLPPSLPGPV--LVNTPV 1995
Query: 157 DFNCSTPYVCLQEQVRLQW--QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRI 214
C+ L W G + + T Q F G + TL A + D GR
Sbjct: 1996 RLTCNATGA---PSPTLMWLKDGNPVSPAGTPGLQVFPG---GRVLTLASARA-SDSGRY 2048
Query: 215 LRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSI 274
+S Q ++ LQV P IL +++ E V L CQ ++ P V S
Sbjct: 2049 SCVAVSAVGEDRQ-DVVLQVHMPPS---ILGEELNVSVVANESVALECQSHAMPPPVLS- 2103
Query: 275 KWLKDGVRLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA 326
W KDG L+ + GV L + +A DAG YTC+A N G S +
Sbjct: 2104 -WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGH------SEKHYNL 2156
Query: 327 EVQVSPAGPILENQTVTLVCNTPNEAPSDLR------YSWYKNHVLLE---------DAH 371
V V+P P+ E+ T+T+ P + R SW K+ L A
Sbjct: 2157 NVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAV 2216
Query: 372 SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTP----VLTAFLETQAGL 427
L L A A G Y CE NV G+ S + + V+ PP T Q G
Sbjct: 2217 GRLLYLGQAQLAQEGTYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDG- 2274
Query: 428 VGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
V L C+ +P T+ G + + G + S L + + +G
Sbjct: 2275 VATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQS---------LHVERAQAAHTG 2325
Query: 488 EYKCSATNSLGNATSTLDFHANAARLLIS---PAAEVVEG--QAVTLSCRSGLSPTPDAR 542
Y C A N G A + LI P + +TL C + P P R
Sbjct: 2326 RYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIR 2385
Query: 543 FSWYLNGALLHEGPGSSLL-------LPAASSTDAGSYHCRARDGHSASGPSSPAVLTVL 595
W+ + G + LL + D+G Y C A + A + VL
Sbjct: 2386 --WFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA--SNEAGEARRNFSVEVL 2441
Query: 596 YPPRQPTFTTRLDLDAA-GAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCS 654
PP DL+ G+ L+C V P +L R +A
Sbjct: 2442 VPPS----IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR--------- 2488
Query: 655 TCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIA 714
G + + +P+ + +++ L G Y C A+NA+G T + Q +VL +A
Sbjct: 2489 ---GDAHHI----SPDGVLLQVLQANLSSAGHYSCIAANAVG----EKTKHFQLSVL-LA 2536
Query: 715 PS--HTLQEGTEANLTCNVSR------EAAGSPA-NFSWFRNGVLWAQGPLETVTLLP-- 763
P+ ++ + +T V+ EA P+ N +W ++G + + LLP
Sbjct: 2537 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEAS--RNIQLLPGT 2594
Query: 764 -------VARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFI 816
+ DA Y C + E G + + VL PP K L ++G + +
Sbjct: 2595 HGLQILNAQKEDAGQYTCVVTNELGEAVKN-YHVEVLIPPSISKDDPLGEVGVKEVKTKV 2653
Query: 817 -------CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869
C + P + + + S QV GR L+++ +
Sbjct: 2654 NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL----------LQIQPTQVS 2703
Query: 870 DSGSYRCEATNVLGSSNTSL--------FFQVRG--------------AWVQVSPSPELQ 907
DSG Y C ATNV G + FQ G A V+ E+
Sbjct: 2704 DSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIV 2763
Query: 908 EGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT-------LRFAAITLTQAGAYHC 960
E L C + P + WYR+ QPL + L+ + AG Y C
Sbjct: 2764 ENNPAYLYCDTNAIPPPDLT--WYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSC 2821
Query: 961 QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020
+A ++ LH Y +T ++ + + S Q L
Sbjct: 2822 KA-------SNEVGEDWLH--YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN 2872
Query: 1021 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080
S LQ G P SPRL V L++ A + D Y+C A N G A
Sbjct: 2873 PVPTISWLQN-GLPFSPSPRLQVLEDGQV--LQVSTAEVADAASYMCVAENQAGSAE--- 2926
Query: 1081 DFDAQAVNVQVWP--------GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL--- 1129
+ VQV P T V+L C V HP TWY+D Q
Sbjct: 2927 --KLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDV-HAHP-NPEVTWYKDSQALSLGE 2982
Query: 1130 ------DAHSIPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVL------YAPRNLR 1176
H++ L + D+ Y C + GR +L + L VL APR +
Sbjct: 2983 EVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL---VQLSVLVPPAFRQAPRGPQ 3039
Query: 1177 LTYLLESHGGQLALVLCTVDSRPPAQLALSHAGR-LLASSTAASVPNTLRLELRGPQPRD 1235
L+ G A++ C D+ P + G+ L+ + ++ RLE++ Q D
Sbjct: 3040 DAVLVRV--GDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSD 3097
Query: 1236 EGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE---GAPITVTCADPAAHAPTLY 1292
+G YSC + G+A + L ++ P+ G+P+ +TC APT+
Sbjct: 3098 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV- 3156
Query: 1293 TWYHNGRWLQEGP-------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYA 1345
TW + ++ L A AG Y+C A++ Q + + + VL A
Sbjct: 3157 TWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQ-AEARKDFVVAVLVA 3215
Query: 1346 PQDAVLSSFRDSRARSMAVIQ--CTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403
P+ R+ ++ C D +PP ++A DG L G H G
Sbjct: 3216 PRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSL 3275
Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV-------EGA----RVVAEPG 1452
V + L+ D A Y C A N G + + + V +GA +V+ P
Sbjct: 3276 VLKG---LRASDAGA----YTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRP- 3327
Query: 1453 LDVPEGAALNLSCRLLGGPGPVGNSTFAWF-------WNDRRLHAEPVPTLAFTHVARAQ 1505
G + + C + G P P+ S W + R L TL + V A
Sbjct: 3328 -----GELVTMVCPVRGSP-PIHVS---WLKDGLPLPLSQRTLLHGSGHTLRISKVQLAD 3378
Query: 1506 AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI---LDCRVDSEPLA 1562
AG++ C+A P G A L+V PP + F +RG L C PL
Sbjct: 3379 AGIFTCVAASPAG-VADRNFTLQVQVPPVLEP-VEFQNDVVVVRGSLVELPCEARGVPLP 3436
Query: 1563 SLT-LHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621
++ + G L++ S QG + +EA+ D G Y C A + G
Sbjct: 3437 LVSWMKDGEPLLSQSLEQGP---------------SLQLEAVGAGDSGTYSCVAVSEAGE 3481
Query: 1622 A 1622
A
Sbjct: 3482 A 3482
Score = 176 bits (445), Expect = 2e-43
Identities = 378/1579 (23%), Positives = 578/1579 (36%), Gaps = 296/1579 (18%)
Query: 200 ETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVT 259
++LH+ + H C RA+ + L V P+ + L + +T
Sbjct: 2312 QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLT 2371
Query: 260 LTCQVNSSYPAVSSIKWLK--------DGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGV 311
L C+ P +I+W + + L +L + Q D+G+Y+C A N
Sbjct: 2372 LLCEAMGIPPP--AIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEA 2429
Query: 312 GSLVSPPISLHIFMAEVQVSPAGP---------ILENQTVTLVCNTPNEAPSDLRYSWYK 362
G + F EV V P+ +L+ QT L+CN L +W+K
Sbjct: 2430 GE------ARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFK 2481
Query: 363 NHVLLEDAHSH-------TLRLHLATRADTGFYFCEVQNVHGSE-RSGPVSVVVNHPPLT 414
+ L +H L++ A + G Y C N G + + +SV+ L
Sbjct: 2482 DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL-----LA 2536
Query: 415 PVLTAFLETQAG---LVGI-----LHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466
P + E A V + L C ++ P + G + S +
Sbjct: 2537 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEA----SRNIQLLP 2592
Query: 467 GTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA-------- 518
GT G L+I + ++ D+G+Y C TN LG A ++H +LI P+
Sbjct: 2593 GTHG-----LQILNAQKEDAGQYTCVVTNELGEAVK--NYH---VEVLIPPSISKDDPLG 2642
Query: 519 ------AEVVEGQAVTLSCRSGLSPTPDARFSWYLNG-------ALLHEGPGSSLLLPAA 565
+ +TL C S P P R WY +G L G G L +
Sbjct: 2643 EVGVKEVKTKVNSTLTLECESWAVPPPTIR--WYKDGQPVTPSSRLQVLGEGRLLQIQPT 2700
Query: 566 SSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP---RQPTFTTRLDL-----DAAGAGAG 617
+D+G Y C A + ++ V PP + F+ ++ +A G
Sbjct: 2701 QVSDSGRYLCVATNVAGEDDQDFNVLIQV--PPMFQKVGDFSAAFEILSREEEARGGVTE 2758
Query: 618 RRGL-------LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPN 670
R + L C ++ PP L +D+ L +G S G +V + P
Sbjct: 2759 YREIVENNPAYLYCDTNAIPPPDLTWYREDQ----PLSAGDEVSVLQG----GRVLQIP- 2809
Query: 671 LLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCN 730
L+R E G Y C+ASN +G + + + L E N +
Sbjct: 2810 LVRA-------ENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASST 2862
Query: 731 VSRE--AAGSPA-NFSWFRNGVLWAQGP----LETVTLLPVAR---TDAALYACRILTEA 780
VS + A G+P SW +NG+ ++ P LE +L V+ DAA Y C +A
Sbjct: 2863 VSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQA 2922
Query: 781 GAQLSTPVLLSVLYPP-----DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHL 835
G+ L V PP D +++A+L+ C V + P + +
Sbjct: 2923 GS-AEKLFTLRVQVPPRIAGLDLEQVTAILNSS----VSLPCDVHAHPNPEVTWYKDSQ- 2976
Query: 836 LATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN--TSLFFQV 893
A SLG +V + L++ L DSG Y CEA N G L V
Sbjct: 2977 -ALSLGEEV--------FLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV 3027
Query: 894 RGAWVQVSPSPE----LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP--LQESTSA---- 943
A+ Q P+ ++ G VLSC+ +PE T WY+DGQP L + T A
Sbjct: 3028 PPAFRQAPRGPQDAVLVRVGDKAVLSCET-DALPEPT-VTWYKDGQPLVLAQRTQALRGG 3085
Query: 944 -TLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYA-PRHVTLTTLMDTGPGRL 1000
L ++ G Y C+ + G A + + + ++ P+ T++ + G
Sbjct: 3086 QRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQV----AGSP 3141
Query: 1001 GLLLCRVDSDPPAQLRLLHGDRL--VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAM 1058
+L C V P + L DR+ +S + GV G RL++
Sbjct: 3142 LVLTCDVSGVPAPTVTWLK-DRMPVESSAVHGVVSRGG--------------RLQLSRLQ 3186
Query: 1059 LEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGAT---------VREGQLVNLTCLV 1109
G Y C A NT QA A DF V V V P V EGQ V L C
Sbjct: 3187 PAQAGTYTCVAENT--QAEARKDF---VVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEA 3241
Query: 1110 WTTHPAQLTYTWYQDGQQ-----------RLDAHSIPLPNVTVRDATSYRC-GVGPPGRA 1157
P + W +DG LD S+ L + DA +Y C P G
Sbjct: 3242 DGQPPPDV--AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 3299
Query: 1158 PRLSRPITLDVLYAP---RNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLAS 1214
RL T++VL P + + L S G+L ++C V PP ++ G L
Sbjct: 3300 ARLH---TVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL 3356
Query: 1215 STAASVPNT-LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP-----E 1268
S + + L + Q D G ++C A SP G A+ + L+++ V +L P +
Sbjct: 3357 SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ-VPPVLEPVEFQND 3415
Query: 1269 AAVPEGAPITVTCADPAAHAPTLYTWYHNG-----RWLQEGPAASLSFLVATRAHAGAYS 1323
V G+ + + C P L +W +G + L++GP+ L + A +G YS
Sbjct: 3416 VVVVRGSLVELPCEARGVPLP-LVSWMKDGEPLLSQSLEQGPSLQLEAVGA--GDSGTYS 3472
Query: 1324 CQAQDAQGTRSSRPAALQVLYAP--QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSH 1381
C A G + R L V+ P +D+ + + + C P +
Sbjct: 3473 CVAVSEAG-EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK 3531
Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQ 1441
DG+ L T +R L+V+D Y C A++ G+I R+
Sbjct: 3532 DGQAL------------TRLENNSRATRVLRVRDA----GLYTCLAESPAGAIEKSFRV- 3574
Query: 1442 VEGARVVAEPGLDVPEG---------AALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP 1492
RV A P + P G L L C + P P W D + E
Sbjct: 3575 ----RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAP----KITWH-RDGIVLQED 3625
Query: 1493 VPT--------LAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLY--PPKTPTMMVFV 1542
T L ++ A +G Y C A AA S V RV P + V
Sbjct: 3626 AHTQFPERGRFLQLQALSTADSGDYSCTAR---NAAGSTSVAFRVEIHTVPTIRSGPPAV 3682
Query: 1543 EPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEA 1602
+L C+ D P A L R+ P P +L +LR I+
Sbjct: 3683 NVSVNQTALLPCQADGVP-APLVSWRKDRVPLD------PRSPRFEILPE-GSLR--IQP 3732
Query: 1603 LRPSDQGEYICSASNVLGS 1621
+ D G Y+C ASN GS
Sbjct: 3733 VLAQDAGHYLCLASNSAGS 3751
Score = 162 bits (410), Expect = 3e-39
Identities = 332/1384 (23%), Positives = 488/1384 (35%), Gaps = 253/1384 (18%)
Query: 252 ILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTG--------VLHLPQAAWSDAGVY 303
+ PGE L+C+V P ++ W++D L TG L + +D G Y
Sbjct: 528 VSPGETAVLSCRVLGEAPY--NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRY 585
Query: 304 TCQAENGVGSL---------VSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPS 354
C A N G +P +S+H + + + V + C+
Sbjct: 586 QCVASNANGVTRASVWLLVREAPQVSIH--------TSSQHFSQGVEVKVSCSASGYPTP 637
Query: 355 DLRYSWYKNHVLLEDAHSH-----TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVN 409
+ +S ++ L ED+ H TL + D G Y C+ N G+++ V++
Sbjct: 638 HISWS-RESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQE-TVTLYYT 695
Query: 410 HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGG--HILASTSGDSDHSPRFSG 467
PP + A + G +L C P ++ GG ILA
Sbjct: 696 DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP------------- 742
Query: 468 TSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFH-ANAARLLISPAAEVVE-GQ 525
G +S +L I +E D+G Y C A N LG+A++ + +A +L P VE G+
Sbjct: 743 -EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGR 801
Query: 526 AVTLSCRSGLSPTPDA---RFSWYLNGALLHEGPGSS--------LLLPAASSTDAGSYH 574
+ L+CR+ P P R G L G GS L + + D Y
Sbjct: 802 SALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYV 861
Query: 575 CRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARL 634
C AR+ + ++T PP+ + G+ L C V + P
Sbjct: 862 CEARNVFGKVQAEARLIVTGHAPPQIAS-----SAPTVRVLEGQPVSLPCIVLAGRPLPE 916
Query: 635 QLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNA 694
+ KD LP G S S + + L E G Y C A+N
Sbjct: 917 RHWLKD---GRPLPPGSRHSIRADGS-------------LHLDRALQEHAGRYSCVATNT 960
Query: 695 LGNASTSATFNGQA--TVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFR-NGVL 750
G+ Q + A H EG A+L C A+G PA +W + L
Sbjct: 961 AGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPC----VASGVPAPTITWTKETNAL 1016
Query: 751 WAQGPLETV----TLL---PVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSA 803
++GP V TLL P A+ DA Y C G S + LSV
Sbjct: 1017 TSRGPHYNVSKEGTLLIAQPSAQ-DAGAYVCTATNTVGFS-SQEMRLSV----------- 1063
Query: 804 LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
LAL E+ L S SL+L
Sbjct: 1064 ------------------NRLALSKYVWEEYGLLPS-----------------GSLRL-- 1086
Query: 864 RELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE---GQAVVLSCQVHT 920
++ +GDSG Y C A+N GS++ V+ QV P P + + G+A+ L+C V
Sbjct: 1087 AQVQVGDSGHYECTASNPAGSASHRYVLGVQ-VPPQVQPGPRVLKVLVGEALDLNC-VAE 1144
Query: 921 GVPEGTSYRWYRDGQPLQ-ESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLH 979
G PE W +DG LQ ++ FAAI + AG Y C+A A + L
Sbjct: 1145 GNPE-PQLSWSKDGVVLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVD---AWEVELR 1200
Query: 980 VSYAPRHVTLTT--LMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGS 1037
V P T L++ G L C P Q+ G + L G G
Sbjct: 1201 VLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPS--SEPLHGQPG---- 1254
Query: 1038 SPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF----------DAQAV 1087
VAV L + D G Y C+A+N +G S A D +
Sbjct: 1255 -----VAVLEEG-SLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKA 1308
Query: 1088 NVQVWPGAT-----------------VREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL- 1129
NV G + +++ QLV + L W + L W Q G RL
Sbjct: 1309 NVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVP-LGWAGYGWDL--GWGQVGGHRLL 1365
Query: 1130 -DAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHG--G 1186
+ S+ P + D+ Y C +A R L VL P L E G G
Sbjct: 1366 DEGQSLHFPRIQEGDSGLYSCRA--ENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAG 1423
Query: 1187 QLALVLCTVDSRPPAQLALSHAGR-LLASSTAASVPNTLR-LELRGPQPRDEGFYSCSAR 1244
+ C P Q+ + + +L V + L + G DEG Y C A
Sbjct: 1424 ADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAF 1483
Query: 1245 SPLGQANTSLELRLEGVRVILAP----EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRW 1300
SP GQ +LR+ I E AV E + + C P + TW+ +G
Sbjct: 1484 SPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNI-TWFKDGAL 1542
Query: 1301 LQEGP-------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSS 1353
L L A + AG Y+C+A +A G ++ A +Y P +
Sbjct: 1543 LPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG--AAEKATRLDVYVPPTIEGAG 1600
Query: 1354 FRDSRARSMA----VIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNAL 1409
R +++A ++C P L+ H+G +A S+ ++ + L
Sbjct: 1601 GRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESN--------ESRLETDGSVL 1652
Query: 1410 RLQVQDVPAGDDTYVCTAQNLLGS--ISTIGRLQVEGARVVAEPGLDVPE--GAALNLSC 1465
RL+ A Y C A + G + +QV +VAE V G L L C
Sbjct: 1653 RLE-SPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPC 1711
Query: 1466 RLLGGPGPVGNSTFAWFWNDRRLH-------AEPVPTLAFTHVARAQAGMYHCLAELPTG 1518
+ G P P T W N R A TL HV +G++ C A G
Sbjct: 1712 QASGSPVP----TIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 1767
Query: 1519 AAAS 1522
A +
Sbjct: 1768 TAGA 1771
Score = 157 bits (398), Expect = 6e-38
Identities = 385/1708 (22%), Positives = 608/1708 (35%), Gaps = 308/1708 (18%)
Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159
L+++ + PED+G+Y+ + +EV +D + + T+ P V + + V + G E
Sbjct: 662 LIIQGVAPEDAGNYSCQ-ATNEVG--TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 718
Query: 160 CSTPYVCLQEQVRLQWQGQDPARSVTFNS---QKFEPTGVGHLETLHMAMSWQDHGRILR 216
C G P R + + P G + A +D G
Sbjct: 719 CEA-------------SGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYT- 764
Query: 217 CQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW 276
C+ A +EI L V +AP+ ++ P + G L C+ P ++ W
Sbjct: 765 CRAVNELGDASAEIQLAVGHAPQLTEL---PRDVTVELGRSALLACRATGRPPP--TVTW 819
Query: 277 LKD-----GVRL---------QTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLH 322
+ G+RL Q +GVL A D Y C+A N G + + +
Sbjct: 820 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 879
Query: 323 IFMAEVQVSPAGP---ILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLR--- 376
A Q++ + P +LE Q V+L C P R+ W K+ L H++R
Sbjct: 880 TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH-WLKDGRPLPPGSRHSIRADG 938
Query: 377 -LHL--ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHC 433
LHL A + G Y C N GS+ VV P + P T + T G+ L C
Sbjct: 939 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHI-TNEGVPASLPC 997
Query: 434 SVVSEPLATL--------VLSHGGHILAS------------------------TSGDSDH 461
P T+ + S G H S T G S
Sbjct: 998 VASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQ 1057
Query: 462 SPRFS--------------GTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFH 507
R S G SLRL ++ DSG Y+C+A+N G+A+ H
Sbjct: 1058 EMRLSVNRLALSKYVWEEYGLLPSGSLRLA--QVQVGDSGHYECTASNPAGSAS-----H 1110
Query: 508 ANAARLLISPAAE-------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH-EGPGSS 559
+ + P + V+ G+A+ L+C + +P P + SW +G +L GP S
Sbjct: 1111 RYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEP--QLSWSKDGVVLQGRGPQGS 1168
Query: 560 LLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRR 619
+ A ++DAG Y C A +SA + L VL PP T L+ AG
Sbjct: 1169 VHFAAIRTSDAGRYRCEA--SNSAGVDAWEVELRVLEPPHWGADETSGLLERV---AGEN 1223
Query: 620 GLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNP 679
L C P ++ R +S P G P + V + +L +
Sbjct: 1224 ASLPCPARGTPKPQVTW----RKGPSSEPLHG--------QPGVAVLEEGSLFLASVSPA 1271
Query: 680 LLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLT------CNVSR 733
+ G Y C+A+N +G+ S +A ++ P ++G +AN++ +
Sbjct: 1272 ---DSGDYECQATNEVGSTSR------RAKLVVYVPPSIREDGRKANVSGMAGQSLTLEC 1322
Query: 734 EAAGSPA-NFSWFRNGVL---------------WAQ-------GPLETVTLLPVARTDAA 770
+A G P W ++ L W Q +++ + D+
Sbjct: 1323 DANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSG 1382
Query: 771 LYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALF 830
LY+CR +AG LL VL PP ++L G L + D +
Sbjct: 1383 LYSCRAENQAGTAQRDFHLL-VLTPP------SVLGAGAAQEVLGLAGADVELQCWTSGV 1435
Query: 831 HGEHLLATS-LGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSL 889
+ T P +P Q + + L++ +G D G Y+C A + G
Sbjct: 1436 PTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSPAGQQARDF 1493
Query: 890 FFQVRGA---W-VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT- 944
+V W + + E V L C+ GVP + W++DG L ST
Sbjct: 1494 QLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEAR-GVPT-PNITWFKDGALLPTSTKVVY 1551
Query: 945 ------LRFAAITLTQAGAYHCQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP 997
L+ + AG Y C+A A G+A + + Y P + G
Sbjct: 1552 TRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-----YVPPTIE-------GA 1599
Query: 998 GRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGA 1057
G ++ V P A + G + G P S + + LRLE G
Sbjct: 1600 GGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGE 1659
Query: 1058 MLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQL 1117
G+Y C AS+ G+A +V VQV P V EG L +T +V P +L
Sbjct: 1660 A--SSGLYSCVASSPAGEAVLQ-----YSVEVQVPPQLLVAEG-LGQVTTIVG--QPLEL 1709
Query: 1118 ----------TYTWYQDG---------QQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAP 1158
T W Q+G Q ++ + +V + + + C
Sbjct: 1710 PCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTA 1769
Query: 1159 RLSRPITLDVLYAPRNLRLT-----YLLESHGGQLALVLCTVDS------RPPAQLALSH 1207
+++ +AP L + + E H A V +PP
Sbjct: 1770 GAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCS 1829
Query: 1208 AGRLLASSTAASVPNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265
G L T V +L L++ RDEG Y+C+A + G++ + L+ V++
Sbjct: 1830 PGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALK-----VLV 1884
Query: 1266 APEA-------AVPEGAPITVTCADPAAHAPTLYTWYHNGR----WLQEGPAASLSFLV- 1313
P AV E A +T+ C P + +W+ + W+ G S+ V
Sbjct: 1885 PPNIEPGPVNKAVLENASVTLECLASGVPPPDV-SWFKGHQPVSSWM--GVTVSVDGRVL 1941
Query: 1314 ----ATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV-IQCT 1368
A + AG+Y C A + G+ R L+V P+ + S + V + C
Sbjct: 1942 RIEQAQLSDAGSYRCVASNVAGSTELR-YGLRVNVPPRITLPPSLPGPVLVNTPVRLTCN 2000
Query: 1369 VDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTA 1427
P L DG ++ + GT +QV L + A D Y C A
Sbjct: 2001 ATGAPSPTLMWLKDGNPVSPA--------GTPGLQVFPGGRVLTLASARASDSGRYSCVA 2052
Query: 1428 QNLLGSISTIGRLQVEGARVVA--EPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWND 1485
+ +G LQV + E + V ++ L C+ P PV +W+ +
Sbjct: 2053 VSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV----LSWWKDG 2108
Query: 1486 RRLHAEPVPTL----AFTHVARAQ---AGMYHCLAELPTGAAA---SAPVMLRVLYPPKT 1535
R L P L A V RA AG Y C A G + + V + ++P +
Sbjct: 2109 RPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRE 2168
Query: 1536 PTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNA 1595
+ E G L C P ++ QP HV A
Sbjct: 2169 SHTLTVRE---GHPTSLSCECRGVPFPKISWR------KDGQPLPGEGAGLQHVSAVGRL 2219
Query: 1596 LRVDIEALRPSDQGEYICSASNVLGSAS 1623
L + L + +G Y C SNV+G++S
Sbjct: 2220 LYLGQAQL--AQEGTYTCECSNVVGNSS 2245
Score = 155 bits (391), Expect = 4e-37
Identities = 382/1680 (22%), Positives = 579/1680 (34%), Gaps = 292/1680 (17%)
Query: 105 LQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELL--EGTEVDFNCST 162
+Q DSG Y+ R E D ++T P V + E+L G +V+ C T
Sbjct: 1376 IQEGDSGLYSCRAENQAGTAQRDFHLLVLT---PPSVLGAGAAQEVLGLAGADVELQCWT 1432
Query: 163 PYVCLQEQVRLQW-QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSV 221
V + ++W + + P + Q E V + H+ D GR S
Sbjct: 1433 SGVPTPQ---VEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG----DEGRYQCVAFSP 1485
Query: 222 ANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGV 281
A +A+ + L+V +AP + ++ LV L C+ +I W KDG
Sbjct: 1486 AGQQAR-DFQLRV-HAPPTIWGSNETGEVAVMEDHLVQLLCEARGV--PTPNITWFKDGA 1541
Query: 282 RLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPA 333
L T T V L L +A SDAGVYTC+A N VG+ L +++
Sbjct: 1542 LLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAG 1600
Query: 334 G-----PILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH-------SHTLRLHLAT 381
G + + V L C L SW+ + + +++ LRL
Sbjct: 1601 GRPYVVKAVAGRPVALECVARGHPSPTL--SWHHEGLPVAESNESRLETDGSVLRLESPG 1658
Query: 382 RADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF--LETQAGLVGILHCSVVSEP 439
A +G Y C + G E SV V PP V + T G L C P
Sbjct: 1659 EASSGLYSCVASSPAG-EAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP 1717
Query: 440 LATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGN 499
+ T+ G +G S GT+ L I +E SG + C ATN G
Sbjct: 1718 VPTIQWLQNGRPAEELAGVQVAS---QGTT------LHIDHVELDHSGLFACQATNEAGT 1768
Query: 500 ATSTLDFHAN---AARLLISPAAEVVEG----QAVTLSCRS------GLSPTPDARFSWY 546
A + ++ + A +L P + G + +C G P P W
Sbjct: 1769 AGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWC 1828
Query: 547 LNGALLHEGPG--------SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
G+L E G L + D G Y C A + A L VL PP
Sbjct: 1829 SPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT--NLAGESKREVALKVLVPP 1886
Query: 599 R-QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCG 657
+P + L+ A L C PP + + V
Sbjct: 1887 NIEPGPVNKAVLENASV------TLECLASGVPPPDVSWFKGHQPV-------------- 1926
Query: 658 GCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATV---LAIA 714
S M VT + + + I L + G Y C ASN G ST + + V + +
Sbjct: 1927 --SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG--STELRYGLRVNVPPRITLP 1982
Query: 715 PS--HTLQEGTEANLTCNVSREAAGSPA-NFSWFRNG--VLWAQGP-------LETVTLL 762
PS + T LTCN A G+P+ W ++G V A P +TL
Sbjct: 1983 PSLPGPVLVNTPVRLTCN----ATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLA 2038
Query: 763 PVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSR 822
+D+ Y+C ++ G V+L V PP + + C +
Sbjct: 2039 SARASDSGRYSCVAVSAVGED-RQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAM 2097
Query: 823 PLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVL 882
P +L+ + P R A+ L+V + D+G Y CEA N
Sbjct: 2098 PPPVLSWWKDGR----------PLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 2147
Query: 883 GSSNTSLFFQVRGAWV------QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP 936
G S V WV + S + ++EG LSC+ GVP W +DGQP
Sbjct: 2148 GHSEKHYNLNV---WVAPVFPLRESHTLTVREGHPTSLSCECR-GVP-FPKISWRKDGQP 2202
Query: 937 LQESTSATLRFAAI---------TLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYA-PR 985
L + +A+ L Q G Y C+ + G+++ L + + A PR
Sbjct: 2203 LPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPR 2262
Query: 986 H-VTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVA 1044
T +++ G + L C PP + T + G P G+ L +
Sbjct: 2263 EPPTQVSVVQDG---VATLECNATGKPPPTV-----------TWERDGQPVGAELGLQLQ 2308
Query: 1045 VAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVN 1104
+L +E A G Y C A N G+A + ++V V P L N
Sbjct: 2309 NQGQSLHVE--RAQAAHTGRYSCVAENLAGRAERKFE-----LSVLVPPELIGDLDPLTN 2361
Query: 1105 LTCLVWTTHPAQL----------TYTWY---------QDGQQRLDAHSIPLPNVTVRDAT 1145
+T + + P L W+ +D + + +D+
Sbjct: 2362 ITAALHS--PLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSG 2419
Query: 1146 SYRCGVGPPGRAPRLSRPITLDVLYAP--RNLRLTYLLESHGGQLALVLCTVDSRPPAQL 1203
Y C A R +++VL P N L +++ GQ A ++C V P +L
Sbjct: 2420 LYSCLAS--NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL 2477
Query: 1204 ALSHAGRLLASSTAASV-PNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVR 1262
GR LA A + P+ + L++ G YSC A + +G+ +L
Sbjct: 2478 TWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQL-----S 2532
Query: 1263 VILAP------------EAAVPEGAPITVTCADPAAHAPTLYTWYHNG------RWLQEG 1304
V+LAP E V PI++ C A +P + TW +G R +Q
Sbjct: 2533 VLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNI-TWMKDGAPFEASRNIQLL 2591
Query: 1305 PAA-SLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP---QDAVLSSFR----D 1356
P L L A + AG Y+C + G + + ++VL P +D L
Sbjct: 2592 PGTHGLQILNAQKEDAGQYTCVVTNELG-EAVKNYHVEVLIPPSISKDDPLGEVGVKEVK 2650
Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416
++ S ++C + PP + DG+ + SS + L G LQ+Q
Sbjct: 2651 TKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR----------LLQIQPT 2700
Query: 1417 PAGDD-TYVCTAQNLLGS--------------ISTIGRLQV--------EGARVVAEPGL 1453
D Y+C A N+ G +G E AR
Sbjct: 2701 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 2760
Query: 1454 DVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA-------EPVPTLAFTHVARAQA 1506
++ E L C P P W+ D+ L A + L V A
Sbjct: 2761 EIVENNPAYLYCDTNAIPPP----DLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENA 2816
Query: 1507 GMYHCLAELPTGAAASAPVMLRVLYPP----KTPTMMVFVEPEGGLRGILDCRVDSEPLA 1562
G Y C A G +L VL PP T ++ V L C P+
Sbjct: 2817 GRYSCKASNEVGEDWLHYELL-VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVP 2875
Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
++ S G P P + + + + +D Y+C A N GSA
Sbjct: 2876 TI----------SWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA 2925
Score = 148 bits (374), Expect = 4e-35
Identities = 309/1299 (23%), Positives = 445/1299 (34%), Gaps = 234/1299 (18%)
Query: 251 NILPGELVTLTCQVNSSYPAVSSIKWLKDG----------VRLQTKTGVLHLPQAAWSDA 300
++L G+ V L C+ + P + WLKDG +R G L L SDA
Sbjct: 3228 HVLEGQEVRLDCEADGQPPP--DVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA 3285
Query: 301 GVYTCQAENGVGS---------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNE 351
G YTC A N G LV P I + VS G + VT+VC
Sbjct: 3286 GAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGEL-----VTMVCPVRGS 3340
Query: 352 APSDLRYSWYKNHVLLE-------DAHSHTLRLHLATRADTGFYFCEVQNVHG-SERSGP 403
P + SW K+ + L HTLR+ AD G + C + G ++R+
Sbjct: 3341 PP--IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFT 3398
Query: 404 VSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP 463
+ V V P L PV E Q +V VV L L G L S D P
Sbjct: 3399 LQVQVP-PVLEPV-----EFQNDVV------VVRGSLVELPCEARGVPLPLVSWMKDGEP 3446
Query: 464 RFSGT--SGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEV 521
S + GP+ L++ + DSG Y C A + G A ++ P
Sbjct: 3447 LLSQSLEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQL------TVMEPPHIE 3497
Query: 522 VEGQAVTLSCRSGL--------SPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSY 573
GQ LS G TP +W+ +G L +S DAG Y
Sbjct: 3498 DSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLY 3557
Query: 574 HCRARDGHSASGPSSPAVLTV---LYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDP 630
C A A S + + PR P F L A + +L C V+++P
Sbjct: 3558 TCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGL--------APGQLVLECSVEAEP 3609
Query: 631 PARLQLLHKDRVVA-----TSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685
++ H+D +V T P G +++ + G
Sbjct: 3610 APKITW-HRDGIVLQEDAHTQFPERGRF--------------------LQLQALSTADSG 3648
Query: 686 LYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANF-SW 744
Y C A NA G STS F + + S N T + +A G PA SW
Sbjct: 3649 DYSCTARNAAG--STSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSW 3706
Query: 745 FRNGV-------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPD 797
++ V + P ++ + PV DA Y C AG+ L VL PP
Sbjct: 3707 RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDL-RVLEPPA 3765
Query: 798 RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEAN 857
+ L + AL C P L+ + L L G ++ +N
Sbjct: 3766 IAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL-----QQGAYRL-LPSN 3819
Query: 858 SLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQA------ 911
+L L G DS + C +N +G ++ R V V P + + Q
Sbjct: 3820 ALLLTAP--GPQDSAQFECVVSNEVGEAH-------RLYQVTVHVPPTIADDQTDFTVTM 3870
Query: 912 ---VVLSCQVHTGVPEGTSYRWYRDGQPL-------QESTSATLRFAAITLTQAGAYHCQ 961
VVL+C TG+P T W + G L + S S L AG Y C
Sbjct: 3871 MAPVVLTCH-STGIPAPT-VSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCS 3928
Query: 962 AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGD 1021
A+ + L V +P L +++ LL C P +
Sbjct: 3929 ARNSAGVAHK---HVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG 3985
Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081
VA+ + P G +L I A ED G Y+C A N+ G A
Sbjct: 3986 LNVATGVSTQVLPGG--------------QLRIAHASPEDAGNYLCIAKNSAGSAMGKTR 4031
Query: 1082 FDAQAVNV--QVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS------ 1133
Q V P + EG L C + +T W +DGQ A
Sbjct: 4032 LVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNIT--WDKDGQPVSGAEGKFTIQP 4089
Query: 1134 ---IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAP--------RNLRLTYLL- 1181
+ + N+ +DA +Y C R R + L +L P R+LRL L
Sbjct: 4090 SGELLVKNLEGQDAGTYTCTA--ENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLW 4147
Query: 1182 ---ESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGF 1238
+ G + TV+ RP + G A S D G
Sbjct: 4148 LRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVS-------------REDSGT 4194
Query: 1239 YSCSARSPLGQANTSLELRLEGVRVILAPEAAV---PEGAPITVTCADPAAHAPTLYTWY 1295
Y C A + +G+ + ++ V+ + P G I + C P ++ W
Sbjct: 4195 YVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIH-WI 4253
Query: 1296 HNG---------RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP 1346
+G LQ G SL+ R AG Y C A++ G + + L + AP
Sbjct: 4254 KDGLPLRGSHLRHQLQNG---SLTIHRTERDDAGRYQCLAENEMGV-AKKVVILVLQSAP 4309
Query: 1347 QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVAR 1406
V R+ ++C EP + G+ L S + +L G+
Sbjct: 4310 VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGS------- 4362
Query: 1407 NALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQVEG 1444
L +++V GD TY C A NLLGS + L V G
Sbjct: 4363 ----LWLENVETGDAGTYDCVAHNLLGSATARAFLVVRG 4397
Score = 145 bits (365), Expect = 4e-34
Identities = 291/1244 (23%), Positives = 437/1244 (35%), Gaps = 225/1244 (18%)
Query: 477 EIRDLEETDSGEYKCSATN--SLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSG 534
EI + + G Y+C+A + G A + + +L+ +P V G+ LSCR
Sbjct: 482 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRV- 540
Query: 535 LSPTPDARFSWYLNGALLHEGPGS-------SLLLPAASSTDAGSYHCRARDGHSASGPS 587
L P +W + +L G SL + TD G Y C A + A+G +
Sbjct: 541 LGEAP-YNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN---ANGVT 596
Query: 588 SPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSL 647
+V ++ Q + T + G + C P + + + +
Sbjct: 597 RASVWLLVREAPQVSIHTSSQHFSQGVEVK----VSCSASGYPTPHISWSRESQALQED- 651
Query: 648 PSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSAT--FN 705
R+ V L+ I E+ G Y C+A+N +G + T +
Sbjct: 652 -------------SRIHVDAQGTLI---IQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 695
Query: 706 GQATVLAIAPSHTLQEGTEANLTCNVSREAAG-SPANFSWFRNG---VLWAQGPLETVTL 761
+V A+ + G EA L C EA+G P W+R G +L +G
Sbjct: 696 DPPSVSAVNAVVLVAVGEEAVLVC----EASGVPPPRVIWYRGGLEMILAPEGSSSGKLR 751
Query: 762 LPVART-DAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVD 820
+P A+ DA Y CR + E G S + L+V + P +L + + G AL C
Sbjct: 752 IPAAQERDAGTYTCRAVNELG-DASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRAT 810
Query: 821 SRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATN 880
RP + G+ LG ++ + GR + +S L + D Y CEA N
Sbjct: 811 GRPPPTVTWRRGD---GQPLGLRLGA-GRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 866
Query: 881 VLGSSNTSLFFQVRG-AWVQVS---PSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP 936
V G V G A Q++ P+ + EGQ V L C V G P + W +DG+P
Sbjct: 867 VFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH-WLKDGRP 925
Query: 937 LQESTSATLRF-AAITLTQA-----GAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLT 990
L + ++R ++ L +A G Y C A + S + L V PR
Sbjct: 926 LPPGSRHSIRADGSLHLDRALQEHAGRYSCVAT---NTAGSQHRDVELVVQVPPRIHPTA 982
Query: 991 TLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTL 1050
T T G L C P + + S P +V+ L
Sbjct: 983 THHITNEGVPASLPCVASGVPAPTITWTKETNALTSR----------GPHYNVSKEGTLL 1032
Query: 1051 RLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVW 1110
I +D G Y+C A+NT+G F +Q + + V
Sbjct: 1033 ---IAQPSAQDAGAYVCTATNTVG-------FSSQEMRLSV------------------- 1063
Query: 1111 TTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLY 1170
A Y W + G L + S+ L V V D+ Y C P A S L V
Sbjct: 1064 -NRLALSKYVWEEYGL--LPSGSLRLAQVQVGDSGHYECTASNP--AGSASHRYVLGVQV 1118
Query: 1171 APRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRG 1230
P+ +L+ G+ + C + P QL+ S G +L RG
Sbjct: 1119 PPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQG--------------RG 1164
Query: 1231 PQ---------PRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTC 1281
PQ D G Y C A + G +ELR V+ P E + +
Sbjct: 1165 PQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELR-----VLEPPHWGADETSGLLERV 1219
Query: 1282 AD-------PAAHAPTLYTWYHNG------------RWLQEGPAASLSFLVATRAHAGAY 1322
A PA P + G L+EG SL + A +G Y
Sbjct: 1220 AGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEG---SLFLASVSPADSGDY 1276
Query: 1323 SCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMA----VIQCTVDSEPPAELA 1378
CQA + G+ S R A V+Y P ++ R + MA ++C + P E+
Sbjct: 1277 ECQATNEVGSTSRR--AKLVVYVPP-SIREDGRKANVSGMAGQSLTLECDANGFPVPEIV 1333
Query: 1379 LSHDGKVLATSSGVHSLASGTGHVQVARNAL-----RLQVQDVPAGDD-TYVCTAQNLLG 1432
D +++ G G QV + L L + GD Y C A+N G
Sbjct: 1334 WLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG 1393
Query: 1433 SISTIGRL------QVEGARVVAEP-GLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWND 1485
+ L V GA E GL GA + L C G P P W
Sbjct: 1394 TAQRDFHLLVLTPPSVLGAGAAQEVLGL---AGADVELQCWTSGVPTPQVE------WTK 1444
Query: 1486 RRLHAEP------------VPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPP 1533
R P V + +HV G Y C+A P G A LRV PP
Sbjct: 1445 DRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSPAGQQAR-DFQLRVHAPP 1501
Query: 1534 KTPTMMVFVEPEGGLRGILD-------CRVDSEPLASLTLHLGSRLVASSQPQGAPAEPH 1586
++ E G +++ C P ++T L+ +S
Sbjct: 1502 T-----IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTK-------- 1548
Query: 1587 IHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGV 1630
V+ + ++ + + SD G Y C ASN +G+A +T V
Sbjct: 1549 --VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 1590
Score = 144 bits (362), Expect = 1e-33
Identities = 356/1523 (23%), Positives = 529/1523 (34%), Gaps = 293/1523 (19%)
Query: 250 RNILPGELVTLTCQVNSSYPAVSSIKWLK--------DGVRLQTKTGVLHLPQAAWSDAG 301
R I+ L C N+ P + W + D V + VL +P +AG
Sbjct: 2760 REIVENNPAYLYCDTNAIPPP--DLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAG 2817
Query: 302 VYTCQAENGVGS--------LVSPPISL---HIFMAEVQVSPAGPILENQTVTLVCNT-P 349
Y+C+A N VG +++PP+ L + EV V+ + TV+L C
Sbjct: 2818 RYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS------TVSLQCPALG 2871
Query: 350 NEAPSDLRYSWYKNHV---------LLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSER 400
N P+ SW +N + +LED L++ A AD Y C +N GS
Sbjct: 2872 NPVPT---ISWLQNGLPFSPSPRLQVLEDGQ--VLQVSTAEVADAASYMCVAENQAGSAE 2926
Query: 401 SGPVSVVVNHPPLTPVL-----TAFLETQAGLVGILHCSVVSEPL---ATLVLSHGGHIL 452
++ V PP L TA L + L +H E + LS G +
Sbjct: 2927 K-LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVF 2985
Query: 453 ASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR 512
P + L++ +DSG Y C A N+ G +
Sbjct: 2986 LL----------------PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLS----- 3024
Query: 513 LLISPAAE-----------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP----- 556
+L+ PA V G LSC + P P +WY +G L
Sbjct: 3025 VLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTV--TWYKDGQPLVLAQRTQAL 3082
Query: 557 --GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGA 614
G L + A +D G Y C+ + A LTV PP T AG+
Sbjct: 3083 RGGQRLEIQEAQVSDKGLYSCKV--SNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGS 3140
Query: 615 GAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRV 674
+L C V P + L KDR+ S G S G R+
Sbjct: 3141 PL----VLTCDVSGVPAPTVTWL-KDRMPVESSAVHGVVSRGG---------------RL 3180
Query: 675 EIHNPLLEEEGLYLCEASNALGNAS----TSATFNGQATVLAIAPSHTLQEGTEANLTCN 730
++ + G Y C A N A + + +A H + EG E L C
Sbjct: 3181 QLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC- 3239
Query: 731 VSREAAGSPA-NFSWFRNGVLWAQ--GPL-------ETVTLLPVARTDAALYACRILTEA 780
EA G P + +W ++G Q GP ++ L + +DA Y C A
Sbjct: 3240 ---EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPA 3296
Query: 781 G--AQLSTPVLLSVLYPPDRPKL---SALLDMGQGHMALFICTV-DSRPLALLALFHGEH 834
G A+L T ++VL PP + S L G + +C V S P+ + L G
Sbjct: 3297 GEDARLHT---VNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDG-- 3351
Query: 835 LLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894
L L + HG + L + ++ L D+G + C A + G ++ + QV
Sbjct: 3352 -LPLPLSQRTLLHG--------SGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV- 3401
Query: 895 GAWVQVSPSPELQE---------GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST---S 942
QV P E E G V L C+ GVP W +DG+PL +
Sbjct: 3402 ----QVPPVLEPVEFQNDVVVVRGSLVELPCEAR-GVPLPL-VSWMKDGEPLLSQSLEQG 3455
Query: 943 ATLRFAAITLTQAGAYHCQA-----QAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP 997
+L+ A+ +G Y C A +A ++ P + S P ++LT P
Sbjct: 3456 PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLT------P 3509
Query: 998 GRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGA 1057
G LLC P + H D + L+ + + A LR+
Sbjct: 3510 GAPMELLCDAQGTPQPNITW-HKDGQALTRLE------------NNSRATRVLRVR---- 3552
Query: 1058 MLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGAT-----VREGQLVNLTCLVWTT 1112
D G+Y C A + G S QA V P + GQLV L C V
Sbjct: 3553 ---DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSV-EA 3607
Query: 1113 HPAQLTYTWYQDG-QQRLDAHS--------IPLPNVTVRDATSYRC----GVGPPGRAPR 1159
PA TW++DG + DAH+ + L ++ D+ Y C G A R
Sbjct: 3608 EPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 3666
Query: 1160 LSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGR--LLASSTA 1217
+ + P + ++ Q AL+ C D PA L R L S
Sbjct: 3667 VEIHTVPTIRSGPPAVNVSV------NQTALLPCQADG-VPAPLVSWRKDRVPLDPRSPR 3719
Query: 1218 ASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPI 1277
+ L ++ +D G Y C A + G +LR +L P A P + +
Sbjct: 3720 FEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR------VLEPPAIAPSPSNL 3773
Query: 1278 TVTCADPA-------AHAPTLYTWYHNGRWL----QEG-----PAASLSFLVATRAHAGA 1321
T+T PA L W+ +G+ L Q+G P+ +L +
Sbjct: 3774 TLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQ 3833
Query: 1322 YSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMA--VIQCTVDSEPPAELAL 1379
+ C + G QV + D MA V+ C P ++
Sbjct: 3834 FECVVSNEVGEAHR---LYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSW 3890
Query: 1380 SHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGR 1439
S G L A G+G+ AL + Q +P Y C+A+N G
Sbjct: 3891 SKAGAQLG--------ARGSGYRVSPSGALEIG-QALPIHAGRYTCSARNSAGVAHKHVF 3941
Query: 1440 LQVEGARVVAEPGLDVPEGAA---LNLSCRLLGGPGPVGNSTFAWFWNDRRL------HA 1490
L V+ + VV +P V A + L C G P P T W +
Sbjct: 3942 LTVQASPVV-KPLPSVVRAVAEEEVLLPCEASGIPRP----TITWQKEGLNVATGVSTQV 3996
Query: 1491 EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRG 1550
P L H + AG Y C+A+ G+A L V PP + + G
Sbjct: 3997 LPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGK-TRLVVQVPPVIENGLPDLSTTEGSHA 4055
Query: 1551 ILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGE 1610
L C+ P ++T + V+ AE + S L ++ L D G
Sbjct: 4056 FLPCKARGSPEPNITWDKDGQPVSG-------AEGKFTIQPSGELL---VKNLEGQDAGT 4105
Query: 1611 YICSASNVLGSASTSTYFGVRAL 1633
Y C+A N +G A + + L
Sbjct: 4106 YTCTAENAVGRARRRVHLTILVL 4128
Score = 140 bits (353), Expect = 1e-32
Identities = 212/859 (24%), Positives = 310/859 (36%), Gaps = 135/859 (15%)
Query: 855 EANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPE--LQEGQAV 912
E+ + E+ + G+Y C A + G+ V Q+ P+P + G+
Sbjct: 475 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETA 534
Query: 913 VLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITL-------TQAGAYHCQAQAP 965
VLSC+V P + W RD + L ST + A ++L T G Y C A
Sbjct: 535 VLSCRVLGEAPYNLT--WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA 592
Query: 966 GSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVA 1025
T A + L V AP+ T+ G + C P + + +
Sbjct: 593 NGVT---RASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ 649
Query: 1026 STLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF--- 1082
R+HV L I G ED G Y C+A+N +G +
Sbjct: 650 -----------EDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 695
Query: 1083 ---DAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL------DAHS 1133
AVN V V G+ L C P ++ WY+ G + + +
Sbjct: 696 DPPSVSAVNAVV----LVAVGEEAVLVCEASGVPPPRV--IWYRGGLEMILAPEGSSSGK 749
Query: 1134 IPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVL 1192
+ +P RDA +Y C V G A S I L V +AP+ L + G+ AL+
Sbjct: 750 LRIPAAQERDAGTYTCRAVNELGDA---SAEIQLAVGHAPQLTELPRDVTVELGRSALLA 806
Query: 1193 CTVDSRPPAQLALSHAG------RLLASSTAAS-VPNTLRLELRGPQPRDEGFYSCSARS 1245
C RPP + RL A + S P++ L P D+ Y C AR+
Sbjct: 807 CRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 866
Query: 1246 PLGQANTSLELRLEGVR----VILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWL 1301
G+ L + G AP V EG P+++ C A W +GR L
Sbjct: 867 VFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPL 926
Query: 1302 QEGPA------ASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR 1355
G SL A + HAG YSC A + G++ R L V P+ ++
Sbjct: 927 PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQ-HRDVELVVQVPPRIHPTATHH 985
Query: 1356 DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR----- 1410
+ A + C P + + + L TS G H S G + +A+ + +
Sbjct: 986 ITNEGVPASLPCVASGVPAPTITWTKETNAL-TSRGPHYNVSKEGTLLIAQPSAQDAGAY 1044
Query: 1411 ---------------------------------------LQVQDVPAGDD-TYVCTAQNL 1430
L++ V GD Y CTA N
Sbjct: 1045 VCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNP 1104
Query: 1431 LGSISTIGRLQVEGARVVAEPG---LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRR 1487
GS S L V+ V +PG L V G AL+L+C G P P +W +
Sbjct: 1105 AGSASHRYVLGVQVPPQV-QPGPRVLKVLVGEALDLNCVAEGNPEP----QLSWSKDGVV 1159
Query: 1488 LHAE-PVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPK--TPTMMVFVEP 1544
L P ++ F + + AG Y C A G A V LRVL PP +E
Sbjct: 1160 LQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVDA-WEVELRVLEPPHWGADETSGLLER 1218
Query: 1545 EGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALR 1604
G L C P +T G SS+P +P + VL + + ++
Sbjct: 1219 VAGENASLPCPARGTPKPQVTWRKG----PSSEP--LHGQPGVAVLEEGSLF---LASVS 1269
Query: 1605 PSDQGEYICSASNVLGSAS 1623
P+D G+Y C A+N +GS S
Sbjct: 1270 PADSGDYECQATNEVGSTS 1288
Score = 130 bits (327), Expect = 1e-29
Identities = 316/1405 (22%), Positives = 475/1405 (33%), Gaps = 267/1405 (19%)
Query: 380 ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEP 439
A++A+ G Y C + G+ R+ +VV PP V + G +L C V+ E
Sbjct: 486 ASKAEEGTYECTAVSRAGTGRA-KAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA 544
Query: 440 LATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG- 498
L +L +++G + L LEI + TD G Y+C A+N+ G
Sbjct: 545 PYNLTWVRDWRVLPASTG---------RVAQLADLSLEISGIIPTDGGRYQCVASNANGV 595
Query: 499 NATSTLDFHANAARLLISPAAE-VVEGQAVTLSCRSGLSPTPDARFSWYLNGALL----- 552
S A ++ I +++ +G V +SC + PTP SW L
Sbjct: 596 TRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTP--HISWSRESQALQEDSR 653
Query: 553 -HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDA 611
H +L++ + DAG+Y C+A + G V P + + L A
Sbjct: 654 IHVDAQGTLIIQGVAPEDAGNYSCQAT---NEVGTDQETVTLYYTDPPSVSAVNAVVLVA 710
Query: 612 AGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNL 671
G A +L+C PP R+ + ++ + P G S ++++ A
Sbjct: 711 VGEEA----VLVCEASGVPPPRV-IWYRGGLEMILAPEGSS-------SGKLRIPAAQE- 757
Query: 672 LRVEIHNPLLEEEGLYLCEASNALGNASTSATFN-GQATVLAIAPSH-TLQEGTEANLTC 729
+ G Y C A N LG+AS G A L P T++ G A L C
Sbjct: 758 ----------RDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLAC 807
Query: 730 NVSREAAGSPANFSWFR-------------NGVLWAQGPLETVTLLPVARTDAALYACRI 776
R P +W R G Q + VA D A Y C
Sbjct: 808 ---RATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEA 864
Query: 777 LTEAG-AQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTV-DSRPLALLALFHGEH 834
G Q ++++ PP + + + +G C V RPL H
Sbjct: 865 RNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLP------ERH 918
Query: 835 LLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSS--NTSLFFQ 892
L G +P R +A+ + L + +G Y C ATN GS + L Q
Sbjct: 919 WLKD--GRPLPPGSRHSIRADGS---LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ 973
Query: 893 VRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRD-------GQPLQESTSATL 945
V + EG L C V +GVP T W ++ G S TL
Sbjct: 974 VPPRIHPTATHHITNEGVPASLPC-VASGVPAPT-ITWTKETNALTSRGPHYNVSKEGTL 1031
Query: 946 RFAAITLTQAGAYHCQA--------QAPGSATTSLAAPISLHVSYA-------------- 983
A + AGAY C A Q + LA + Y
Sbjct: 1032 LIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQV 1091
Query: 984 --PRHVTLTTLMDTGPGR----LGLLLCRVDSDPPAQLRLLHGDRL-VASTLQGVGGPEG 1036
H T G LG+ + P L++L G+ L + +G P+
Sbjct: 1092 GDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQL 1151
Query: 1037 SSPRLHVAVAPNTLRLEIHGAML--EDEGVYICEASNTLGQASASADFDAQAVNVQV--- 1091
S + V + + +H A + D G Y CEASN SA DA V ++V
Sbjct: 1152 SWSKDGVVLQGRGPQGSVHFAAIRTSDAGRYRCEASN-------SAGVDAWEVELRVLEP 1204
Query: 1092 --WPGATVREGQL-------VNLTCLVWTTHPAQLTY--------TWYQDGQQRLDAHSI 1134
W GA G L +L C T Q+T+ Q G L+ S+
Sbjct: 1205 PHW-GADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSL 1263
Query: 1135 PLPNVTVRDATSYRC----GVGPPGRAPRLSRPITLDVLYAPRNLR---LTYLLESHGGQ 1187
L +V+ D+ Y C VG R +L V+Y P ++R + GQ
Sbjct: 1264 FLASVSPADSGDYECQATNEVGSTSRRAKL-------VVYVPPSIREDGRKANVSGMAGQ 1316
Query: 1188 LALVLCTVDSRPPAQLA-----------LSHAG-------------RLLASSTAASVPNT 1223
+ C + P ++ L AG RLL + P
Sbjct: 1317 SLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRI 1376
Query: 1224 LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVP----EGAPITV 1279
Q D G YSC A + G A L + +L AA GA + +
Sbjct: 1377 --------QEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVEL 1428
Query: 1280 TCADPAAHAPTLYTWYHNGRWLQEGPAASL----SFLVATRAHA---GAYSCQAQDAQGT 1332
C P + L GP + L T +H G Y C A G
Sbjct: 1429 QCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAG- 1487
Query: 1333 RSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQ-------CTVDSEPPAELALSHDGKV 1385
+ +R L+V P + + + +AV++ C P + DG +
Sbjct: 1488 QQARDFQLRVHAPP-----TIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGAL 1542
Query: 1386 LATSSGVHSLASGTGHVQVARNALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQVEG 1444
L TS+ V R +LQ+ + D Y C A N +G+ RL V
Sbjct: 1543 LPTST----------KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV 1592
Query: 1445 ARVVAEPG-----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFW--------NDRRLHAE 1491
+ G + G + L C G P P T +W N+ RL +
Sbjct: 1593 PPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP----TLSWHHEGLPVAESNESRLETD 1648
Query: 1492 PVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI 1551
L A +G+Y C+A P G A +L+ + P ++ E G + I
Sbjct: 1649 G-SVLRLESPGEASSGLYSCVASSPAGEA-----VLQYSVEVQVPPQLLVAEGLGQVTTI 1702
Query: 1552 ------LDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRP 1605
L C+ P+ ++ G PAE V + + I+ +
Sbjct: 1703 VGQPLELPCQASGSPVPTI----------QWLQNGRPAEELAGVQVASQGTTLHIDHVEL 1752
Query: 1606 SDQGEYICSASNVLGSASTSTYFGV 1630
G + C A+N G+A V
Sbjct: 1753 DHSGLFACQATNEAGTAGAEVEVSV 1777
Score = 124 bits (311), Expect = 8e-28
Identities = 263/1141 (23%), Positives = 402/1141 (35%), Gaps = 168/1141 (14%)
Query: 188 SQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSP 247
SQ+ G GH TL ++ I C + A LQV+ P +L
Sbjct: 3357 SQRTLLHGSGH--TLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPP----VLEPV 3410
Query: 248 SGRN---ILPGELVTLTCQVNS-SYPAVSSIKWLKDGVRLQTKT----GVLHLPQAAWSD 299
+N ++ G LV L C+ P VS W+KDG L +++ L L D
Sbjct: 3411 EFQNDVVVVRGSLVELPCEARGVPLPLVS---WMKDGEPLLSQSLEQGPSLQLEAVGAGD 3467
Query: 300 AGVYTCQAENGVG--------SLVSPPISLHIFMA----EVQVSPAGPILENQTVTLVCN 347
+G Y+C A + G +++ PP HI + E+ ++P P+ L+C+
Sbjct: 3468 SGTYSCVAVSEAGEARRHFQLTVMEPP---HIEDSGQPTELSLTPGAPM------ELLCD 3518
Query: 348 TPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGS-ERSGPVSV 406
++ +W+K+ L +++ + D G Y C ++ G+ E+S V V
Sbjct: 3519 AQGTPQPNI--TWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRV 3576
Query: 407 VVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466
+ P F+ A +L CSV +EP + G +L +
Sbjct: 3577 QAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAH--------- 3627
Query: 467 GTSGPNSLR-LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLIS--PAAEVVE 523
T P R L+++ L DSG+Y C+A N+ G+ + + + S PA V
Sbjct: 3628 -TQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSV 3686
Query: 524 GQAVTLSCRSGLSPTPDARFSWYLNGALLHEG-------PGSSLLLPAASSTDAGSYHCR 576
Q L C++ P P SW + L P SL + + DAG Y C
Sbjct: 3687 NQTALLPCQADGVPAP--LVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCL 3744
Query: 577 ARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQL 636
A +SA L VL PP + L L A LL C P +
Sbjct: 3745 A--SNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPA-----LLPCEASGSPKPLVVW 3797
Query: 637 LHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG 696
+ + L G ++ + LL + P ++ + C SN +G
Sbjct: 3798 WKDGQKLDFRLQQGA-----------YRLLPSNALL---LTAPGPQDSAQFECVVSNEVG 3843
Query: 697 NAST--SATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNGV---- 749
A T + T+ T+ LTC+ + G PA SW + G
Sbjct: 3844 EAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCH----STGIPAPTVSWSKAGAQLGA 3899
Query: 750 ------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSA 803
+ G LE LP+ A Y C AG V L+V P L +
Sbjct: 3900 RGSGYRVSPSGALEIGQALPI---HAGRYTCSARNSAGVA-HKHVFLTVQASPVVKPLPS 3955
Query: 804 LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
++ L C P + +AT + QV G+ L +
Sbjct: 3956 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ-----------LRI 4004
Query: 864 RELGLGDSGSYRCEATNVLGSS--NTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTG 921
D+G+Y C A N GS+ T L QV P EG L C+ G
Sbjct: 4005 AHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKAR-G 4063
Query: 922 VPEGTSYRWYRDGQPLQEST-------SATLRFAAITLTQAGAYHCQAQAPGSATTSLAA 974
PE + W +DGQP+ + S L + AG Y C A+ +A
Sbjct: 4064 SPE-PNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAE---NAVGRARR 4119
Query: 975 PISLHVSYAPRHVTLTTLMDTGPGRLG---LLLCRVDSDPPAQLRLLHGDRLVASTLQGV 1031
+ L + P TTL RLG L C P ++ DR V +GV
Sbjct: 4120 RVHLTILVLP---VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT---EGV 4173
Query: 1032 GGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF---DAQAVN 1088
+G S AV+ ED G Y+C A N +G+ A + +A +
Sbjct: 4174 SEQDGGSTLQRAAVSR------------EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQ 4221
Query: 1089 VQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDG--------QQRLDAHSIPLPNVT 1140
+ + G + L C+V + W +DG + +L S+ +
Sbjct: 4222 GEAFSYLVEPVGGSIQLDCVVRGDPVPDIH--WIKDGLPLRGSHLRHQLQNGSLTIHRTE 4279
Query: 1141 VRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRP 1199
DA Y+C G A ++ + L + AP + G + C P
Sbjct: 4280 RDDAGRYQCLAENEMGVAKKV---VILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEP 4336
Query: 1200 PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE 1259
+ AG+ L +S L L + D G Y C A + LG A L +
Sbjct: 4337 TPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 4396
Query: 1260 G 1260
G
Sbjct: 4397 G 4397
Score = 108 bits (271), Expect = 3e-23
Identities = 163/663 (24%), Positives = 244/663 (36%), Gaps = 72/663 (10%)
Query: 1002 LLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061
L+ C V S P +L+L G+ + H + N+ EI A +
Sbjct: 445 LVSCSVHSALPFRLQLRRGEARLGE-------------ERHFQESGNS-SWEILRASKAE 490
Query: 1062 EGVYICEASNTLGQASASADFDAQAVNVQVWPG--ATVREGQLVNLTCLVWTTHPAQLTY 1119
EG Y C A + G A A Q+ P TV G+ L+C V P LT
Sbjct: 491 EGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT- 549
Query: 1120 TWYQDGQ---------QRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLY 1170
W +D + +L S+ + + D Y+C R S + L V
Sbjct: 550 -WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS--VWLLVRE 606
Query: 1171 APRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRG 1230
AP+ T G V C+ P ++ S + L + V L ++G
Sbjct: 607 APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQG 666
Query: 1231 PQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAA--VPEGAPITVTCADPAAHA 1288
P D G YSC A + +G ++ L + A A V G + C + +
Sbjct: 667 VAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC-EASGVP 725
Query: 1289 PTLYTWYHNGRWLQEGPAAS----LSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLY 1344
P WY G + P S L A AG Y+C+A + G S+ L V +
Sbjct: 726 PPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE-IQLAVGH 784
Query: 1345 APQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSH-DGKVLATSSGVHSLASGTGHVQ 1403
APQ L A++ C PP + DG+ L L +G G
Sbjct: 785 APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL-----RLGAGRGSRS 839
Query: 1404 VARNALRLQVQDV-PAGDDTYVCTAQNLLGSISTIGRLQVEGAR----VVAEPGLDVPEG 1458
++ L + V P YVC A+N+ G + RL V G + P + V EG
Sbjct: 840 RQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEG 899
Query: 1459 AALNLSCRLLGG-PGPVGNSTFAWFWNDRRL---HAEPVPTLAFTHVARA---QAGMYHC 1511
++L C +L G P P + W + R L + H+ RA AG Y C
Sbjct: 900 QPVSLPCIVLAGRPLPERH----WLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSC 955
Query: 1512 LAELPTGAAASAPVMLRVLYPPKT-PTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGS 1570
+A T + V L V PP+ PT + E G+ L C P ++T +
Sbjct: 956 VA-TNTAGSQHRDVELVVQVPPRIHPTATHHITNE-GVPASLPCVASGVPAPTITWTKET 1013
Query: 1571 RLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGV 1630
+ S P ++ ++A P+A D G Y+C+A+N +G +S V
Sbjct: 1014 NALTSRGPHYNVSKEGTLLIAQPSA----------QDAGAYVCTATNTVGFSSQEMRLSV 1063
Query: 1631 RAL 1633
L
Sbjct: 1064 NRL 1066
Score = 83.6 bits (205), Expect = 2e-15
Identities = 116/457 (25%), Positives = 168/457 (36%), Gaps = 52/457 (11%)
Query: 1187 QLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSA--R 1244
Q LV C+V S P +L L L E+ +EG Y C+A R
Sbjct: 442 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSR 501
Query: 1245 SPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWL--Q 1302
+ G+A + + +++ AP V G ++C AP TW + R L
Sbjct: 502 AGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR-VLGEAPYNLTWVRDWRVLPAS 560
Query: 1303 EGPAASLSFLV-----ATRAHAGAYSCQAQDAQG-TRSSRPAALQVLYAPQDAVLSSFRD 1356
G A L+ L G Y C A +A G TR+S L V APQ ++ +S +
Sbjct: 561 TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS--VWLLVREAPQVSIHTSSQH 618
Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416
+ C+ P ++ S + + L S +H A GT L +Q V
Sbjct: 619 FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT-----------LIIQGV 667
Query: 1417 -PAGDDTYVCTAQNLLGS-ISTIGRLQVEGARVVAEPGLD-VPEGAALNLSCRLLGGPGP 1473
P Y C A N +G+ T+ + V A + V G L C G P P
Sbjct: 668 APEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPP 727
Query: 1474 VGNSTFAWFWNDRRLHAEPVPT----LAFTHVARAQAGMYHCLAELPTGAAASAPVMLRV 1529
W+ + P + L AG Y C A G ASA + L V
Sbjct: 728 ----RVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELG-DASAEIQLAV 782
Query: 1530 LYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLH------LGSRLVASSQPQGAPA 1583
+ P+ + V E G +L CR P ++T LG RL A +
Sbjct: 783 GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRS--- 839
Query: 1584 EPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620
P++ + E++ P DQ Y+C A NV G
Sbjct: 840 -------RQPDSGVLFFESVAPEDQAPYVCEARNVFG 869
Score = 75.1 bits (183), Expect = 5e-13
Identities = 173/795 (21%), Positives = 273/795 (34%), Gaps = 129/795 (16%)
Query: 910 QAVVLSCQVHTGVPEGTSYR----WYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAP 965
Q +++SC VH+ +P R + + QES +++ + + G Y C A
Sbjct: 442 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAV-- 499
Query: 966 GSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVA 1025
S + A + V+ P + + PG +L CRV + P L + R++
Sbjct: 500 -SRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL- 557
Query: 1026 STLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF--- 1082
P + +A L LEI G + D G Y C ASN G AS
Sbjct: 558 --------PASTGRVAQLA----DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR 605
Query: 1083 DAQAVNVQVWPGATVREGQLVNLTC---------LVWTTHPAQLTYTWYQDGQQRLDAH- 1132
+A V++ +G V ++C + W+ L +D + +DA
Sbjct: 606 EAPQVSIHT-SSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL----QEDSRIHVDAQG 660
Query: 1133 SIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVL 1192
++ + V DA +Y C +TL P + ++ G+ A+++
Sbjct: 661 TLIIQGVAPEDAGNYSCQA--TNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 718
Query: 1193 CTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANT 1252
C PP ++ G + + S LR+ Q RD G Y+C A + LG A+
Sbjct: 719 CEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIP--AAQERDAGTYTCRAVNELGDASA 776
Query: 1253 SLELRLEGVRVI--LAPEAAVPEGAPITVTCADPAAHAPTLYTWYH-------------N 1297
++L + + L + V G + C PT+ TW
Sbjct: 777 EIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTV-TWRRGDGQPLGLRLGAGR 835
Query: 1298 GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLS--SFR 1355
G ++ + L F Y C+A++ G + + +AP S + R
Sbjct: 836 GSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVR 895
Query: 1356 DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQD 1415
+ +++ + P E DG+ L S A G+ H+ A LQ
Sbjct: 896 VLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRA-----LQEH- 949
Query: 1416 VPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLD--VPEGAALNLSCRLLGGPGP 1473
AG Y C A N GS L V+ + EG +L C G P P
Sbjct: 950 --AG--RYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP 1005
Query: 1474 VGNSTFAWFWNDRRL-------HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVM 1526
T W L + TL + AG Y C A G ++
Sbjct: 1006 ----TITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQE--- 1058
Query: 1527 LRVLYPPKTPTMMVFVE----PEGGLR---------GILDCRVDSEPLAS---------- 1563
+R+ + V+ E P G LR G +C S P S
Sbjct: 1059 MRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTA-SNPAGSASHRYVLGVQ 1117
Query: 1564 -----------LTLHLGSRLVASSQPQGAPAEPHIHVLASPNALR-------VDIEALRP 1605
L + +G L + +G P EP + L+ V A+R
Sbjct: 1118 VPPQVQPGPRVLKVLVGEALDLNCVAEGNP-EPQLSWSKDGVVLQGRGPQGSVHFAAIRT 1176
Query: 1606 SDQGEYICSASNVLG 1620
SD G Y C ASN G
Sbjct: 1177 SDAGRYRCEASNSAG 1191
Score = 66.2 bits (160), Expect = 3e-10
Identities = 118/490 (24%), Positives = 177/490 (36%), Gaps = 79/490 (16%)
Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT-LRLELRGPQPRDEGFYSCSAR 1244
G+ A++ C V P L R+L +ST L LE+ G P D G Y C A
Sbjct: 531 GETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVAS 590
Query: 1245 SPLGQANTSLELRLEGVRVILAPEAAV-------PEGAPITVTCADPAAHAPTLYTWYHN 1297
+ G S+ L + AP+ ++ +G + V+C+ P + +W
Sbjct: 591 NANGVTRASVWLLVRE-----APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI-SWSRE 644
Query: 1298 GRWLQEGPA------ASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVL 1351
+ LQE +L AG YSCQA + GT L P + +
Sbjct: 645 SQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGT-DQETVTLYYTDPPSVSAV 703
Query: 1352 SSFRDSRARSMAVIQCTVDSEPPAELALSHDG-KVLATSSGVHSLASGTGHVQVARNALR 1410
++ AV+ C PP + G +++ G S +G +++
Sbjct: 704 NAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG-----SSSGKLRIPA---- 754
Query: 1411 LQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPE--GAALNLSCRLL 1468
Q+ AG TY C A N LG S +L V A + E DV G + L+CR
Sbjct: 755 --AQERDAG--TYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRAT 810
Query: 1469 GGPGPVGNSTFAWFWND-------------RRLHAEPVPTLAFTHVARAQAGMYHCLAEL 1515
G P P T W D R L F VA Y C A
Sbjct: 811 GRPPP----TVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 866
Query: 1516 PTGAA-ASAPVMLRVLYPPK----TPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGS 1570
G A A +++ PP+ PT+ V ++ +P++ + L
Sbjct: 867 VFGKVQAEARLIVTGHAPPQIASSAPTVRV---------------LEGQPVSLPCIVLAG 911
Query: 1571 RLVASSQ--PQGAPAEPHI-HVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTY 1627
R + G P P H + + +L +D AL+ G Y C A+N GS
Sbjct: 912 RPLPERHWLKDGRPLPPGSRHSIRADGSLHLD-RALQ-EHAGRYSCVATNTAGSQHRDVE 969
Query: 1628 FGVRALHRLH 1637
V+ R+H
Sbjct: 970 LVVQVPPRIH 979
Score = 47.4 bits (111), Expect = 1e-04
Identities = 82/328 (25%), Positives = 119/328 (36%), Gaps = 37/328 (11%)
Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159
LL+K+L+ +D+G+Y E + V T++ + P T+ L G +
Sbjct: 4093 LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL---PVFTTLPGDRSLRLGDRLWLR 4149
Query: 160 CSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQL 219
C+ R+ W D R VT E G L+ A+S +D G + C
Sbjct: 4150 CAARG---SPTPRIGWTVND--RPVTEGVS--EQDGGSTLQ--RAAVSREDSGTYV-CWA 4199
Query: 220 SVANHRAQSEIHLQVKYAP----KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIK 275
R Q+ + VK AP + L+ P G +I L C V V I
Sbjct: 4200 ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSI------QLDCVVRGD--PVPDIH 4251
Query: 276 WLKDGVRL-------QTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEV 328
W+KDG+ L Q + G L + + DAG Y C AEN +G I +
Sbjct: 4252 WIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVF 4311
Query: 329 QVSPAG-PILENQTVTLVCNTPNEAPSDLRYSWYKNHVL----LEDAHSHTLRLHLATRA 383
QV P + V L C E + + + L +L L
Sbjct: 4312 QVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETG 4371
Query: 384 DTGFYFCEVQNVHGSERSGPVSVVVNHP 411
D G Y C N+ GS + VV P
Sbjct: 4372 DAGTYDCVAHNLLGSATARAFLVVRGEP 4399
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 205 bits (522), Expect = 3e-52
Identities = 356/1491 (23%), Positives = 543/1491 (36%), Gaps = 255/1491 (17%)
Query: 259 TLTCQVNSSYPAVSSIKWLKDGV------RLQTKTG--VLHLPQAAWSDAGVYTCQAENG 310
T++ Q + V +I WL++G+ RLQ VL + A +DA Y C AEN
Sbjct: 1580 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ 1639
Query: 311 VGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLR------YSWYKNH 364
GS +F VQV P L+ + VT + N+ P D+ +WYK+
Sbjct: 1640 AGSAEK------LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDS 1693
Query: 365 VLLEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSERS-GPVSVVV----NHPP 412
L +HTL+L A +D+G Y CE N G ++ +SV+V P
Sbjct: 1694 QALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAP 1753
Query: 413 LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPN 472
P + + G +L C + P T+ G L R G
Sbjct: 1754 RGPQDAVLV--RVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQ-------RTQALRGGQ 1804
Query: 473 SLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE---GQAVTL 529
RLEI++ + +D G Y C +N G A T +P E V G + L
Sbjct: 1805 --RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVL 1862
Query: 530 SCRSGLSPTPDARFSWY-----LNGALLH--EGPGSSLLLPAASSTDAGSYHCRARDGHS 582
+C +S P +W + + +H G L L AG+Y C A + +
Sbjct: 1863 TC--DVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA 1920
Query: 583 ASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRV 642
+ V+ VL PR + + G+ L C D PP + L
Sbjct: 1921 EA--RKDFVVAVLVAPRIRSSGVAREHHVL---EGQEVRLDCEADGQPPPDVAWLKDGSP 1975
Query: 643 VATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSA 702
+ + GG S +K +A + G Y C A N G +
Sbjct: 1976 LGQDMGPHLRFYLDGG-SLVLKGLRA-------------SDAGAYTCVAHNPAGEDARLH 2021
Query: 703 TFNGQATVLAIAPSHTLQEGTEAN---------LTCNVSREAAGSPANFSWFRNGV---- 749
T N + + P T+++G + + L V P + SW ++G+
Sbjct: 2022 TVN-----VLVPP--TIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL 2074
Query: 750 ---LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLD 806
G T+ + V DA ++ C + AG L V PP + D
Sbjct: 2075 SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGV-ADRNFTLQVQVPPVLEPVEFQND 2133
Query: 807 --MGQGHMALFICTVDSRPLALLA-LFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
+ +G + C PL L++ + GE LL+ SL Q PS L++
Sbjct: 2134 VVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSL-EQGPS--------------LQL 2178
Query: 864 RELGLGDSGSYRCEATNVLGSSNTSLFFQV-RGAWVQVSPSP---ELQEGQAVVLSCQVH 919
+G GDSG+Y C A + G + V ++ S P L G + L C
Sbjct: 2179 EAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 2238
Query: 920 TGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSA-----TTSLAA 974
G P+ + W++DGQ L + + + + AG Y C A++P A + A
Sbjct: 2239 -GTPQ-PNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQA 2296
Query: 975 PISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034
P ++ PR V + PG+L +L C V+++P ++ H D +V
Sbjct: 2297 PPNIVGPRGPRFV-----VGLAPGQL-VLECSVEAEPAPKI-TWHRDGIVL--------- 2340
Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG 1094
H L++ D G Y C A N G S A V++
Sbjct: 2341 ---QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSV-------AFRVEIHTV 2390
Query: 1095 ATVREGQ-----LVNLTCLVWTTH---PAQLTYTWYQDGQ---------QRLDAHSIPLP 1137
T+R G VN T L+ PA L +W +D + L S+ +
Sbjct: 2391 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLV-SWRKDRVPLDPRSPRFEILPEGSLRIQ 2449
Query: 1138 NVTVRDATSYRC------GVGPPGRAPRLSRPITLDVLYAPRNLRLT------YLLESHG 1185
V +DA Y C G GR R+ P + +P NL LT E+ G
Sbjct: 2450 PVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPA--IAPSPSNLTLTAHTPALLPCEASG 2507
Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARS 1245
LV+ D + A RLL S+ L L P P+D + C +
Sbjct: 2508 SPKPLVVWWKDGQKLDFRLQQGAYRLLPSNA---------LLLTAPGPQDSAQFECVVSN 2558
Query: 1246 PLGQANTSLELRLEGVRVILAPEAA-------VPEGAPITVTCADPAAHAPTLYTWYHNG 1298
+G+A+ RL V V + P A V AP+ +TC APT+ +W G
Sbjct: 2559 EVGEAH-----RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTV-SWSKAG 2612
Query: 1299 RWL-------QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVL 1351
L + P+ +L A HAG Y+C A+++ G + + L V +P L
Sbjct: 2613 AQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPL 2671
Query: 1352 SSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRL 1411
S + A ++ C P + +G +AT GV + G +++A +
Sbjct: 2672 PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVAT--GVSTQVLPGGQLRIAHAS--- 2726
Query: 1412 QVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAE--PGLDVPEGAALNLSCRLLG 1469
P Y+C A+N GS RL V+ V+ P L EG+ L C+ G
Sbjct: 2727 -----PEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARG 2781
Query: 1470 GPGPVGNSTFAWFWN---------DRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAA 1520
P P N T W+ + + +P L ++ AG Y C AE G A
Sbjct: 2782 SPEP--NIT----WDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRA 2835
Query: 1521 ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQG 1580
V L +L P T+ G R L C P + + R V
Sbjct: 2836 RRR-VHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG---- 2890
Query: 1581 APAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
V + A+ D G Y+C A N +G ++ V+
Sbjct: 2891 --------VSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 2933
Score = 202 bits (515), Expect = 2e-51
Identities = 373/1573 (23%), Positives = 580/1573 (36%), Gaps = 263/1573 (16%)
Query: 194 TGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNIL 253
+ VG L L A Q+ C V N + ++ L+V P+ P+ +++
Sbjct: 932 SAVGRLLYLGQAQLAQEGTYTCECSNVVGN--SSQDLQLEVHVPPQIAGPREPPTQVSVV 989
Query: 254 PGELVTLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTC 305
+ TL C P ++ W +DG ++LQ + LH+ +A + G Y+C
Sbjct: 990 QDGVATLECNATGKPPP--TVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 1047
Query: 306 QAENGVGSLVSPPISLHIFMAEVQVSPAGPILE-----NQTVTLVCNTPNEAPSDLRYSW 360
AEN G L + + + P+ + +TL+C P +R W
Sbjct: 1048 VAENLAGR-AERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIR--W 1104
Query: 361 YKNHVLL---EDAH----SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413
++ + ED + L++ D+G Y C N G R SV V PP
Sbjct: 1105 FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRN-FSVEVLVPPS 1163
Query: 414 --TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGP 471
L ++ G L C+V P L G LA GD+ H P
Sbjct: 1164 IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR--GDAHHI-------SP 1214
Query: 472 NSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAE-------VVEG 524
+ + L++ + +G Y C A N++G T A ++ A + V
Sbjct: 1215 DGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVN 1274
Query: 525 QAVTLSCRSGLSPTPDARFSWYLNGALLHEG------PGS-SLLLPAASSTDAGSYHCRA 577
++L C + P+P+ +W +GA PG+ L + A DAG Y C
Sbjct: 1275 NPISLICEALAFPSPN--ITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVV 1332
Query: 578 RDGHSASGPSSPAVLTVLYPPR--QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635
+ + + + VL PP + + + L C + PP ++
Sbjct: 1333 TNELGEAVKNYH--VEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIR 1390
Query: 636 LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695
+KD T S R++V LL+++ + + G YLC A+N
Sbjct: 1391 W-YKDGQPVTP-------------SSRLQVLGEGRLLQIQPTQ--VSDSGRYLCVATNVA 1434
Query: 696 GNASTS--------------ATFNGQATVLA--------IAPSHTLQEGTEANLTCNVSR 733
G F+ +L+ + + E A L C+ +
Sbjct: 1435 GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTN- 1493
Query: 734 EAAGSPANFSWFRNGVLWAQGPLETVTL------LPVARTD-AALYACRILTEAGAQLST 786
A P + +W+R + G +V +P+ R + A Y+C+ E G
Sbjct: 1494 --AIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 1551
Query: 787 PVLLSVLYPP----DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGP 842
LL VL PP D +L + + C P+ ++ + S
Sbjct: 1552 YELL-VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRL 1610
Query: 843 QVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSP 902
QV G+ L+V + D+ SY C A N GS+ F +R VQV P
Sbjct: 1611 QVLEDGQV----------LQVSTAEVADAASYMCVAENQAGSAEK--LFTLR---VQVPP 1655
Query: 903 ---SPELQEGQAVV-----LSCQVHTGV-PEGTSYRWYRDGQPLQESTSA-------TLR 946
+L++ A++ L C VH PE T WY+D Q L TL+
Sbjct: 1656 RIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT---WYKDSQALSLGEEVFLLPGTHTLQ 1712
Query: 947 FAAITLTQAGAYHCQA-QAPG--SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLL 1003
L+ +G Y C+A A G L+ + APR L+ G +L
Sbjct: 1713 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDK--AVL 1770
Query: 1004 LCRVDSDP-PAQLRLLHGDRLV-ASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061
C D+ P P G LV A Q + G + RLEI A + D
Sbjct: 1771 SCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ---------------RLEIQEAQVSD 1815
Query: 1062 EGVYICEASNTLGQASASADFDAQAVNVQVWPGA-TVRE--GQLVNLTCLVWTTHPAQLT 1118
+G+Y C+ SN G+A + Q P TV + G + LTC V + PA T
Sbjct: 1816 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV-SGVPAP-T 1873
Query: 1119 YTWYQDGQQRLDAHSIPLPNVTVR------------DATSYRCGVGPPGRAPRLSRPITL 1166
TW +D R+ S + V R A +Y C R + +
Sbjct: 1874 VTWLKD---RMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR--KDFVV 1928
Query: 1167 DVLYAPRNLRLTYLLESH---GGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT 1223
VL APR +R + + H GQ + C D +PP +A G L +
Sbjct: 1929 AVLVAPR-IRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY 1987
Query: 1224 L---RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP---EAAVPEGAPI 1277
L L L+G + D G Y+C A +P G+ + RL V V++ P + A G +
Sbjct: 1988 LDGGSLVLKGLRASDAGAYTCVAHNPAGE-----DARLHTVNVLVPPTIKQGADGSGTLV 2042
Query: 1278 T-----VTCADPAAHAPTLY-TWYHNG-------RWLQEGPAASLSFLVATRAHAGAYSC 1324
+ VT P +P ++ +W +G R L G +L A AG ++C
Sbjct: 2043 SRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC 2102
Query: 1325 QAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRA--RSMAVIQCTVDSEPPAELALSHD 1382
A G + R LQV P + D S+ + C P ++ D
Sbjct: 2103 VAASPAGV-ADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD 2161
Query: 1383 GKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQ 1441
G+ L + SL G LQ++ V AGD TY C A + G +L
Sbjct: 2162 GEPLLS----QSLEQGPS----------LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 2207
Query: 1442 VEGARVVAEPG----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLA 1497
V + + G L + GA + L C G P P W + + L + A
Sbjct: 2208 VMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQP----NITWHKDGQALTRLENNSRA 2263
Query: 1498 FTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYP-----PKTPTMMVFVEPEGGLRGIL 1552
+ AG+Y CLAE P GA + +RV P P+ P +V + P G L +L
Sbjct: 2264 TRVLRVRDAGLYTCLAESPAGAIEKS-FRVRVQAPPNIVGPRGPRFVVGLAP-GQL--VL 2319
Query: 1553 DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612
+C V++EP +T H G + H + ++AL +D G+Y
Sbjct: 2320 ECSVEAEPAPKITWH----------RDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYS 2369
Query: 1613 CSASNVLGSASTS 1625
C+A N GS S +
Sbjct: 2370 CTARNAAGSTSVA 2382
Score = 201 bits (511), Expect = 5e-51
Identities = 379/1557 (24%), Positives = 563/1557 (36%), Gaps = 298/1557 (19%)
Query: 258 VTLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTCQAEN 309
V+L C V++ +P + W KD V L T L L +A SD+G+YTC+A N
Sbjct: 1673 VSLPCDVHA-HPN-PEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALN 1730
Query: 310 GVG---SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVL 366
G LV + + + P +L V + +A + +WYK+
Sbjct: 1731 AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQP 1790
Query: 367 LEDAH-------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPP-LTPVLT 418
L A L + A +D G Y C+V NV G E ++ V PP T
Sbjct: 1791 LVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKT 1849
Query: 419 AFLETQAGLVGILHCSVVSEPLATL--------VLSHGGHILASTSGDSDHSPRFSGTSG 470
+ AG +L C V P T+ V S H + S G
Sbjct: 1850 ETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGG------------- 1896
Query: 471 PNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN---AARLLISPAAE---VVEG 524
RL++ L+ +G Y C A N+ A DF A R+ S A V+EG
Sbjct: 1897 ----RLQLSRLQPAQAGTYTCVAENTQAEARK--DFVVAVLVAPRIRSSGVAREHHVLEG 1950
Query: 525 QAVTLSCRSGLSPTPDARFSWYLNGALLHE--GP-------GSSLLLPAASSTDAGSYHC 575
Q V L C + P PD +W +G+ L + GP G SL+L ++DAG+Y C
Sbjct: 1951 QEVRLDCEADGQPPPDV--AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2008
Query: 576 RARDGHSASGPSSPA-VLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLL---CRVDSDPP 631
A H+ +G + + VL PP T + D +G R G L+ C V PP
Sbjct: 2009 VA---HNPAGEDARLHTVNVLVPP-----TIKQGADGSGTLVSRPGELVTMVCPVRGSPP 2060
Query: 632 ARLQLL------------------HKDRVVATSLPSGGGCSTCGGCSPR--------MKV 665
+ L H R+ L + G TC SP ++V
Sbjct: 2061 IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQL-ADAGIFTCVAASPAGVADRNFTLQV 2119
Query: 666 TKAPNLLRVEIHNPLLEEEGLYL---CEASN----------------------------- 693
P L VE N ++ G + CEA
Sbjct: 2120 QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLE 2179
Query: 694 ALGNASTSATFN-------GQAT----VLAIAPSHTLQEG--TEANLTCNVSRE----AA 736
A+G A S T++ G+A + + P H G TE +LT E A
Sbjct: 2180 AVG-AGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 2238
Query: 737 GSPA-NFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP 795
G+P N +W ++G + + + DA LY C + AGA + + V P
Sbjct: 2239 GTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGA-IEKSFRVRVQAP 2297
Query: 796 PD-----RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRF 850
P+ P+ L GQ + C+V++ P + +L Q P GRF
Sbjct: 2298 PNIVGPRGPRFVVGLAPGQ---LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF 2354
Query: 851 QAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV----SPSPEL 906
L+++ L DSG Y C A N GS TS+ F+V V P+ +
Sbjct: 2355 ----------LQLQALSTADSGDYSCTARNAAGS--TSVAFRVEIHTVPTIRSGPPAVNV 2402
Query: 907 QEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST-------SATLRFAAITLTQAGAYH 959
Q +L CQ GVP W +D PL + +LR + AG Y
Sbjct: 2403 SVNQTALLPCQAD-GVP-APLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL 2460
Query: 960 CQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDP-PAQLRL 1017
C A + GS + + AP LT T LL C P P +
Sbjct: 2461 CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTP----ALLPCEASGSPKPLVVWW 2516
Query: 1018 LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQAS 1077
G +L QG S+ L A P +D + C SN +G+A
Sbjct: 2517 KDGQKLDFRLQQGAYRLLPSNALLLTAPGP------------QDSAQFECVVSNEVGEAH 2564
Query: 1078 ASADFDAQAVNVQVWPGATVREGQ----LVNLTCLVWTTHPAQL---TYTWYQDGQQRLD 1130
V V V P T+ + Q + + +V T H + T +W + G Q L
Sbjct: 2565 R-----LYQVTVHVPP--TIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ-LG 2616
Query: 1131 AHSIPLPNVTVRDATSYRCGVGPPGRAPRLS-----------RPITLDVLYAPRNLRLTY 1179
A V + + G P A R + + + L V +P L
Sbjct: 2617 ARG---SGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPS 2673
Query: 1180 LLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFY 1239
++ + + L+ C P + G +A+ + V +L + P D G Y
Sbjct: 2674 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNY 2733
Query: 1240 SCSARSPLGQA--NTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN 1297
C A++ G A T L +++ V P+ + EG+ + C + P + TW +
Sbjct: 2734 LCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNI-TWDKD 2792
Query: 1298 GRWLQ--EG-----PAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAV 1350
G+ + EG P+ L AG Y+C A++A G R+ R L +L P
Sbjct: 2793 GQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG-RARRRVHLTILVLPVFTT 2851
Query: 1351 LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR 1410
L R R ++C P + + + + + S V+R
Sbjct: 2852 LPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSRE--- 2908
Query: 1411 LQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV---AEPGLDVPEGAALNLSCRL 1467
TYVC A+N +G + + V+ A V+ A L P G ++ L C +
Sbjct: 2909 --------DSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV 2960
Query: 1468 LGGPGPVGNSTFAWFWNDRRL------HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAA 1521
G P P W + L H +L R AG Y CLAE G A
Sbjct: 2961 RGDPVP----DIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAK 3016
Query: 1522 SAPVMLRVLYPPKTPTMMVF-VEPE-----GGLRGILDCRVDSEPLASLT-LHLGSRLVA 1574
+++ P VF VEP+ G L C+ EP ++ L G L A
Sbjct: 3017 KVVILVLQSAP-------VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRA 3069
Query: 1575 SSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
S + + P + +E + D G Y C A N+LGSA+ + VR
Sbjct: 3070 SRRLRTLPDGS------------LWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3114
Score = 180 bits (457), Expect = 9e-45
Identities = 398/1681 (23%), Positives = 604/1681 (35%), Gaps = 297/1681 (17%)
Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRV---PTIASPVELLEGTEV 156
L ++ Q D+GSY R S V ++++ L V PR+ P++ PV L T V
Sbjct: 659 LRIEQAQLSDAGSY--RCVASNVAGSTELRYGL-RVNVPPRITLPPSLPGPV--LVNTPV 713
Query: 157 DFNCSTPYVCLQEQVRLQW--QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRI 214
C+ L W G + + T Q F G + TL A + D GR
Sbjct: 714 RLTCNATGA---PSPTLMWLKDGNPVSPAGTPGLQVFPG---GRVLTLASARA-SDSGRY 766
Query: 215 LRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSI 274
+S Q ++ LQV P IL +++ E V L CQ ++ P V S
Sbjct: 767 SCVAVSAVGEDRQ-DVVLQVHMPPS---ILGEELNVSVVANESVALECQSHAMPPPVLS- 821
Query: 275 KWLKDGVRLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA 326
W KDG L+ + GV L + +A DAG YTC+A N G S +
Sbjct: 822 -WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGH------SEKHYNL 874
Query: 327 EVQVSPAGPILENQTVTLVCNTPNEAPSDLR------YSWYKNHVLLE---------DAH 371
V V+P P+ E+ T+T+ P + R SW K+ L A
Sbjct: 875 NVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAV 934
Query: 372 SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTP----VLTAFLETQAGL 427
L L A A G Y CE NV G+ S + + V+ PP T Q G
Sbjct: 935 GRLLYLGQAQLAQEGTYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDG- 992
Query: 428 VGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
V L C+ +P T+ G + + G + S L + + +G
Sbjct: 993 VATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQS---------LHVERAQAAHTG 1043
Query: 488 EYKCSATNSLGNATSTLDFHANAARLLIS---PAAEVVEG--QAVTLSCRSGLSPTPDAR 542
Y C A N G A + LI P + +TL C + P P R
Sbjct: 1044 RYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIR 1103
Query: 543 FSWYLNGALLHEGPGSSLL-------LPAASSTDAGSYHCRARDGHSASGPSSPAVLTVL 595
W+ + G + LL + D+G Y C A + A + VL
Sbjct: 1104 --WFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA--SNEAGEARRNFSVEVL 1159
Query: 596 YPPRQPTFTTRLDLDAA-GAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCS 654
PP DL+ G+ L+C V P +L R +A
Sbjct: 1160 VPPS----IENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR--------- 1206
Query: 655 TCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIA 714
G + + +P+ + +++ L G Y C A+NA+G T + Q +VL +A
Sbjct: 1207 ---GDAHHI----SPDGVLLQVLQANLSSAGHYSCIAANAVG----EKTKHFQLSVL-LA 1254
Query: 715 PS--HTLQEGTEANLTCNVSR------EAAGSPA-NFSWFRNGVLWAQGPLETVTLLP-- 763
P+ ++ + +T V+ EA P+ N +W ++G + + LLP
Sbjct: 1255 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEAS--RNIQLLPGT 1312
Query: 764 -------VARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFI 816
+ DA Y C + E G + + VL PP K L ++G + +
Sbjct: 1313 HGLQILNAQKEDAGQYTCVVTNELGEAVKN-YHVEVLIPPSISKDDPLAEVGVKEVKTKV 1371
Query: 817 -------CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869
C + P + + + S QV GR L+++ +
Sbjct: 1372 NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRL----------LQIQPTQVS 1421
Query: 870 DSGSYRCEATNVLGSSNTSL--------FFQVRG--------------AWVQVSPSPELQ 907
DSG Y C ATNV G + FQ G A V+ E+
Sbjct: 1422 DSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIV 1481
Query: 908 EGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT-------LRFAAITLTQAGAYHC 960
E L C + P + WYR+ QPL + L+ + AG Y C
Sbjct: 1482 ENNPAYLYCDTNAIPPPDLT--WYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSC 1539
Query: 961 QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020
+A ++ LH Y +T ++ + + S Q L
Sbjct: 1540 KA-------SNEVGEDWLH--YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGN 1590
Query: 1021 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080
S LQ G P SPRL V L++ A + D Y+C A N G A
Sbjct: 1591 PVPTISWLQN-GLPFSPSPRLQVLEDGQV--LQVSTAEVADAASYMCVAENQAGSAE--- 1644
Query: 1081 DFDAQAVNVQVWP--------GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL--- 1129
+ VQV P T V+L C V HP TWY+D Q
Sbjct: 1645 --KLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDV-HAHP-NPEVTWYKDSQALSLGE 1700
Query: 1130 ------DAHSIPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVL------YAPRNLR 1176
H++ L + D+ Y C + GR +L + L VL APR +
Sbjct: 1701 EVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL---VQLSVLVPPAFRQAPRGPQ 1757
Query: 1177 LTYLLESHGGQLALVLCTVDSRPPAQLALSHAGR-LLASSTAASVPNTLRLELRGPQPRD 1235
L+ G A++ C D+ P + G+ L+ + ++ RLE++ Q D
Sbjct: 1758 DAVLVRV--GDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSD 1815
Query: 1236 EGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE---GAPITVTCADPAAHAPTLY 1292
+G YSC + G+A + L ++ P+ G+P+ +TC APT+
Sbjct: 1816 KGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV- 1874
Query: 1293 TWYHNGRWLQEGP-------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYA 1345
TW + ++ L A AG Y+C A++ Q + + + VL A
Sbjct: 1875 TWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQ-AEARKDFVVAVLVA 1933
Query: 1346 PQDAVLSSFRDSRARSMAVIQ--CTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403
P+ R+ ++ C D +PP ++A DG L G H G
Sbjct: 1934 PRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSL 1993
Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV-------EGA----RVVAEPG 1452
V + L+ D A Y C A N G + + + V +GA +V+ P
Sbjct: 1994 VLKG---LRASDAGA----YTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRP- 2045
Query: 1453 LDVPEGAALNLSCRLLGGPGPVGNSTFAWF-------WNDRRLHAEPVPTLAFTHVARAQ 1505
G + + C + G P P+ S W + R L TL + V A
Sbjct: 2046 -----GELVTMVCPVRGSP-PIHVS---WLKDGLPLPLSQRTLLHGSGHTLRISKVQLAD 2096
Query: 1506 AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI---LDCRVDSEPLA 1562
AG++ C+A P G A L+V PP + F +RG L C PL
Sbjct: 2097 AGIFTCVAASPAG-VADRNFTLQVQVPPVLEP-VEFQNDVVVVRGSLVELPCEARGVPLP 2154
Query: 1563 SLT-LHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621
++ + G L++ S QG + +EA+ D G Y C A + G
Sbjct: 2155 LVSWMKDGEPLLSQSLEQGP---------------SLQLEAVGAGDSGTYSCVAVSEAGE 2199
Query: 1622 A 1622
A
Sbjct: 2200 A 2200
Score = 176 bits (446), Expect = 2e-43
Identities = 381/1579 (24%), Positives = 580/1579 (36%), Gaps = 296/1579 (18%)
Query: 200 ETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVT 259
++LH+ + H C RA+ + L V P+ + L + +T
Sbjct: 1030 QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLT 1089
Query: 260 LTCQVNSSYPAVSSIKWLK--------DGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGV 311
L C+ P +I+W + + L +L + Q D+G+Y+C A N
Sbjct: 1090 LLCEAMGIPPP--AIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEA 1147
Query: 312 GSLVSPPISLHIFMAEVQVSPAGP---------ILENQTVTLVCNTPNEAPSDLRYSWYK 362
G + F EV V P+ +L+ QT L+CN L +W+K
Sbjct: 1148 GE------ARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL--TWFK 1199
Query: 363 NHVLLEDAHSH-------TLRLHLATRADTGFYFCEVQNVHGSE-RSGPVSVVVNHPPLT 414
+ L +H L++ A + G Y C N G + + +SV+ L
Sbjct: 1200 DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL-----LA 1254
Query: 415 PVLTAFLETQAG---LVGI-----LHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466
P + E A V + L C ++ P + G + S +
Sbjct: 1255 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEA----SRNIQLLP 1310
Query: 467 GTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA-------A 519
GT G L+I + ++ D+G+Y C TN LG A ++H +LI P+ A
Sbjct: 1311 GTHG-----LQILNAQKEDAGQYTCVVTNELGEAVK--NYH---VEVLIPPSISKDDPLA 1360
Query: 520 EV-------VEGQAVTLSCRSGLSPTPDARFSWYLNG-------ALLHEGPGSSLLLPAA 565
EV +TL C S P P R WY +G L G G L +
Sbjct: 1361 EVGVKEVKTKVNSTLTLECESWAVPPPTIR--WYKDGQPVTPSSRLQVLGEGRLLQIQPT 1418
Query: 566 SSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP---RQPTFTTRLDL-----DAAGAGAG 617
+D+G Y C A + ++ V PP + F+ ++ +A G
Sbjct: 1419 QVSDSGRYLCVATNVAGEDDQDFNVLIQV--PPMFQKVGDFSAAFEILSREEEARGGVTE 1476
Query: 618 RRGL-------LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPN 670
R + L C ++ PP L +D+ L +G S G +V + P
Sbjct: 1477 YREIVENNPAYLYCDTNAIPPPDLTWYREDQ----PLSAGDEVSVLQG----GRVLQIP- 1527
Query: 671 LLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCN 730
L+R E G Y C+ASN +G + + + L E N +
Sbjct: 1528 LVRA-------ENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASST 1580
Query: 731 VSRE--AAGSPA-NFSWFRNGVLWAQGP----LETVTLLPVAR---TDAALYACRILTEA 780
VS + A G+P SW +NG+ ++ P LE +L V+ DAA Y C +A
Sbjct: 1581 VSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQA 1640
Query: 781 GAQLSTPVLLSVLYPP-----DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHL 835
G+ L V PP D +++A+L+ C V + P + +
Sbjct: 1641 GS-AEKLFTLRVQVPPRIAGLDLEQVTAILNSS----VSLPCDVHAHPNPEVTWYKDSQ- 1694
Query: 836 LATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN--TSLFFQV 893
A SLG +V + L++ L DSG Y CEA N G L V
Sbjct: 1695 -ALSLGEEV--------FLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV 1745
Query: 894 RGAWVQVSPSPE----LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP--LQESTSA---- 943
A+ Q P+ ++ G VLSC+ +PE T WY+DGQP L + T A
Sbjct: 1746 PPAFRQAPRGPQDAVLVRVGDKAVLSCET-DALPEPT-VTWYKDGQPLVLAQRTQALRGG 1803
Query: 944 -TLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYA-PRHVTLTTLMDTGPGRL 1000
L ++ G Y C+ + G A + + + ++ P+ T++ + G
Sbjct: 1804 QRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQV----AGSP 1859
Query: 1001 GLLLCRVDSDPPAQLRLLHGDRL--VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAM 1058
+L C V P + L DR+ +S + GV G RL++
Sbjct: 1860 LVLTCDVSGVPAPTVTWLK-DRMPVESSAVHGVVSRGG--------------RLQLSRLQ 1904
Query: 1059 LEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGAT---------VREGQLVNLTCLV 1109
G Y C A NT QA A DF V V V P V EGQ V L C
Sbjct: 1905 PAQAGTYTCVAENT--QAEARKDF---VVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEA 1959
Query: 1110 WTTHPAQLTYTWYQDGQQ-----------RLDAHSIPLPNVTVRDATSYRC-GVGPPGRA 1157
P + W +DG LD S+ L + DA +Y C P G
Sbjct: 1960 DGQPPPDV--AWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 2017
Query: 1158 PRLSRPITLDVLYAP---RNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLAS 1214
RL T++VL P + + L S G+L ++C V PP ++ G L
Sbjct: 2018 ARLH---TVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL 2074
Query: 1215 STAASVPNT-LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP-----E 1268
S + + L + Q D G ++C A SP G A+ + L+++ V +L P +
Sbjct: 2075 SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ-VPPVLEPVEFQND 2133
Query: 1269 AAVPEGAPITVTCADPAAHAPTLYTWYHNG-----RWLQEGPAASLSFLVATRAHAGAYS 1323
V G+ + + C P L +W +G + L++GP+ L + A +G YS
Sbjct: 2134 VVVVRGSLVELPCEARGVPLP-LVSWMKDGEPLLSQSLEQGPSLQLEAVGA--GDSGTYS 2190
Query: 1324 CQAQDAQGTRSSRPAALQVLYAP--QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSH 1381
C A G + R L V+ P +D+ + + + C P +
Sbjct: 2191 CVAVSEAG-EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK 2249
Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQ 1441
DG+ L T +R L+V+D Y C A++ G+I R+
Sbjct: 2250 DGQAL------------TRLENNSRATRVLRVRDA----GLYTCLAESPAGAIEKSFRV- 2292
Query: 1442 VEGARVVAEPGLDVPEG---------AALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP 1492
RV A P + P G L L C + P P W D + E
Sbjct: 2293 ----RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAP----KITWH-RDGIVLQED 2343
Query: 1493 VPT--------LAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLY--PPKTPTMMVFV 1542
T L ++ A +G Y C A AA S V RV P + V
Sbjct: 2344 AHTQFPERGRFLQLQALSTADSGDYSCTAR---NAAGSTSVAFRVEIHTVPTIRSGPPAV 2400
Query: 1543 EPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEA 1602
+L C+ D P A L R+ P P +L +LR I+
Sbjct: 2401 NVSVNQTALLPCQADGVP-APLVSWRKDRVPLD------PRSPRFEILPE-GSLR--IQP 2450
Query: 1603 LRPSDQGEYICSASNVLGS 1621
+ D G Y+C ASN GS
Sbjct: 2451 VLAQDAGHYLCLASNSAGS 2469
Score = 162 bits (409), Expect = 3e-39
Identities = 357/1546 (23%), Positives = 551/1546 (35%), Gaps = 319/1546 (20%)
Query: 253 LPGELVTLTCQVNSSYPAVSSIKWLKD-----------------------GVRLQTKTGV 289
+ G+ +TL C N +P V I WLKD G RL +
Sbjct: 31 MAGQSLTLECDANG-FP-VPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQS 88
Query: 290 LHLPQAAWSDAGVYTCQAENGVGS--------LVSPPISLHIFMAEVQVSPAGPILENQT 341
LH P+ D+G+Y+C+AEN G+ +++PP L A+ + AG +E Q
Sbjct: 89 LHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQC 148
Query: 342 VTLVCNTPNEAPSDLRYSWYKN---------HVLLEDAHSHTLRLHLATRADTGFYFCEV 392
T TP + W K+ H+ +++ LR+ + D G Y C
Sbjct: 149 WTSGVPTP-------QVEWTKDRQPVLPGGPHLQVQE-DGQVLRITGSHVGDEGRYQCVA 200
Query: 393 QNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILH-------CSVVSEPLATLVL 445
+ G +++ + V+ PP T + + G V ++ C P +
Sbjct: 201 FSPAG-QQARDFQLRVHAPP-----TIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW 254
Query: 446 SHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD 505
G +L + S + T G +L++ + +D+G Y C A+N++G A
Sbjct: 255 FKDGALLPT-------STKVVYTRG--GRQLQLGRAQSSDAGVYTCKASNAVGAAEK--- 302
Query: 506 FHANAARLLISPAAE----------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEG 555
A + + P E V G+ V L C + P+P SW+ G + E
Sbjct: 303 --ATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP--TLSWHHEGLPVAES 358
Query: 556 -------PGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVL----TVLYPPRQPTFT 604
GS L L + +G Y C AS P+ AVL V PP+
Sbjct: 359 NESRLETDGSVLRLESPGEASSGLYSC------VASSPAGEAVLQYSVEVQVPPQL---- 408
Query: 605 TRLDLDAAGAG-----AGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGC 659
L A G G G+ L C+ P +Q L R A L
Sbjct: 409 ----LVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR-PAEELAG---------- 453
Query: 660 SPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG--NASTSATFNGQ-ATVLAIAPS 716
V A + I + L+ GL+ C+A+N G A + +G+ A + P
Sbjct: 454 -----VQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPI 508
Query: 717 HTLQEGTEANLTCNVSREA---------AGSPANFSWFRNGVLWAQ--GPLETVTLLP-- 763
G E + + + + P W G LW + G +L P
Sbjct: 509 GQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPL 568
Query: 764 ----VARTDAALYACRILTEAGAQLSTPVLLSVLYPPD---RPKLSALLDMGQGHMALFI 816
V D +Y C AG + V L VL PP+ P A+L+
Sbjct: 569 QIEKVDLRDEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENAS---VTLE 624
Query: 817 CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRC 876
C P ++ F G +++ +G V GR L + + L D+GSYRC
Sbjct: 625 CLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----------LRIEQAQLSDAGSYRC 674
Query: 877 EATNVLGSSNTSLFFQVRGAWVQVSPS---PELQEGQAVV-----LSCQVHTGVPEGTSY 928
A+NV GS T L + +R V V P P G +V L+C TG P T
Sbjct: 675 VASNVAGS--TELRYGLR---VNVPPRITLPPSLPGPVLVNTPVRLTCNA-TGAPSPT-L 727
Query: 929 RWYRDGQPLQESTS---------ATLRFAAITLTQAGAYHCQA-QAPGSATTSLAAPISL 978
W +DG P+ + + L A+ + +G Y C A A G + + +
Sbjct: 728 MWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHM 787
Query: 979 HVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSS 1038
S + ++ + + L C+ + PP L R +
Sbjct: 788 PPSILGEELNVSVVANESVA----LECQSHAMPPPVLSWWKDGRPL-------------E 830
Query: 1039 PRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVR 1098
PR V ++ + L++ A + D G Y CEA N G + + +NV V P +R
Sbjct: 831 PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYN-----LNVWVAPVFPLR 885
Query: 1099 EGQLVNLTCLVWTTHPAQLT----------YTWYQDGQ---------QRLDA--HSIPLP 1137
E T V HP +L+ +W +DGQ Q + A + L
Sbjct: 886 ESH----TLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLG 941
Query: 1138 NVTVRDATSYRCGVGPPGRAPRLSRPITLDV-----LYAPRNLRLTYLLESHGGQLALVL 1192
+ +Y C S+ + L+V + PR + G +A +
Sbjct: 942 QAQLAQEGTYTCECS--NVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDG--VATLE 997
Query: 1193 CTVDSRPPAQLALSHAGRLLASSTAASVPNT-LRLELRGPQPRDEGFYSCSARSPLGQAN 1251
C +PP + G+ + + + N L + Q G YSC A + G+A
Sbjct: 998 CNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAE 1057
Query: 1252 TSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNG------RWLQ-EG 1304
EL +L P + + P+T A A H+P G RW + E
Sbjct: 1058 RKFELS------VLVPPELIGDLDPLTNITA--ALHSPLTLLCEAMGIPPPAIRWFRGEE 1109
Query: 1305 PAA------------SLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP--QDAV 1350
P + L +G YSC A + G + R +++VL P ++
Sbjct: 1110 PVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAG-EARRNFSVEVLVPPSIENED 1168
Query: 1351 LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR 1410
L A + C V P +L DG+ LA H G +QV
Sbjct: 1169 LEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGV-LLQV------ 1221
Query: 1411 LQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV-------EGARVVAEPGLDVPEGAALNL 1463
LQ AG Y C A N +G + +L V GA A+ + V ++L
Sbjct: 1222 LQANLSSAGH--YSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISL 1279
Query: 1464 SCRLLGGPGPVGNSTF----AWFWNDRRLHAEP-VPTLAFTHVARAQAGMYHCLAELPTG 1518
C L P P N T+ A F R + P L + + AG Y C+ G
Sbjct: 1280 ICEALAFPSP--NITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 1337
Query: 1519 AAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASS-- 1576
A + VL PP + + L + V ++ ++LTL S V
Sbjct: 1338 EAVK-NYHVEVLIPPS-------ISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTI 1389
Query: 1577 --QPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620
G P P + + I+ + SD G Y+C A+NV G
Sbjct: 1390 RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAG 1435
Score = 155 bits (391), Expect = 4e-37
Identities = 382/1680 (22%), Positives = 580/1680 (34%), Gaps = 292/1680 (17%)
Query: 105 LQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELL--EGTEVDFNCST 162
+Q DSG Y+ R E D ++T P V + E+L G +V+ C T
Sbjct: 94 IQEGDSGLYSCRAENQAGTAQRDFHLLVLT---PPSVLGAGAAQEVLGLAGADVELQCWT 150
Query: 163 PYVCLQEQVRLQW-QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSV 221
V + ++W + + P + Q E V + H+ D GR S
Sbjct: 151 SGVPTPQ---VEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG----DEGRYQCVAFSP 203
Query: 222 ANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGV 281
A +A+ + L+V +AP + ++ LV L C+ +I W KDG
Sbjct: 204 AGQQAR-DFQLRV-HAPPTIWGSNETGEVAVMEDHLVQLLCEARGV--PTPNITWFKDGA 259
Query: 282 RLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPA 333
L T T V L L +A SDAGVYTC+A N VG+ L +++
Sbjct: 260 LLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAG 318
Query: 334 G-----PILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH-------SHTLRLHLAT 381
G + + V L C L SW+ + + +++ LRL
Sbjct: 319 GRPYVVKAVAGRPVALECVARGHPSPTL--SWHHEGLPVAESNESRLETDGSVLRLESPG 376
Query: 382 RADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF--LETQAGLVGILHCSVVSEP 439
A +G Y C + G E SV V PP V + T G L C P
Sbjct: 377 EASSGLYSCVASSPAG-EAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP 435
Query: 440 LATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGN 499
+ T+ G +G S GT+ L I +E SG + C ATN G
Sbjct: 436 VPTIQWLQNGRPAEELAGVQVAS---QGTT------LHIDHVELDHSGLFACQATNEAGT 486
Query: 500 ATSTLDFHAN---AARLLISPAAEVVEG----QAVTLSCRS------GLSPTPDARFSWY 546
A + ++ + A +L P + G + +C G P P W
Sbjct: 487 AGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWC 546
Query: 547 LNGALLHEGPG--------SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
G+L E G L + D G Y C A + A L VL PP
Sbjct: 547 SPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT--NLAGESKREVALKVLVPP 604
Query: 599 R-QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCG 657
+P + L+ A L C PP + + V
Sbjct: 605 NIEPGPVNKAVLENASV------TLECLASGVPPPDVSWFKGHQPV-------------- 644
Query: 658 GCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATV---LAIA 714
S M VT + + + I L + G Y C ASN G ST + + V + +
Sbjct: 645 --SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG--STELRYGLRVNVPPRITLP 700
Query: 715 PS--HTLQEGTEANLTCNVSREAAGSPA-NFSWFRNG--VLWAQGP-------LETVTLL 762
PS + T LTCN A G+P+ W ++G V A P +TL
Sbjct: 701 PSLPGPVLVNTPVRLTCN----ATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLA 756
Query: 763 PVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSR 822
+D+ Y+C ++ G V+L V PP + + C +
Sbjct: 757 SARASDSGRYSCVAVSAVGED-RQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAM 815
Query: 823 PLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVL 882
P +L+ + P R A+ L+V + D+G Y CEA N
Sbjct: 816 PPPVLSWWKDGR----------PLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 865
Query: 883 GSSNTSLFFQVRGAWV------QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP 936
G S V WV + S + ++EG LSC+ GVP W +DGQP
Sbjct: 866 GHSEKHYNLNV---WVAPVFPLRESHTLTVREGHPTRLSCECR-GVP-FPKISWRKDGQP 920
Query: 937 LQESTSATLRFAAI---------TLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYA-PR 985
L + +A+ L Q G Y C+ + G+++ L + + A PR
Sbjct: 921 LPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPR 980
Query: 986 H-VTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVA 1044
T +++ G + L C PP + T + G P G+ L +
Sbjct: 981 EPPTQVSVVQDG---VATLECNATGKPPPTV-----------TWERDGQPVGAELGLQLQ 1026
Query: 1045 VAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVN 1104
+L +E A G Y C A N G+A + ++V V P L N
Sbjct: 1027 NQGQSLHVE--RAQAAHTGRYSCVAENLAGRAERKFE-----LSVLVPPELIGDLDPLTN 1079
Query: 1105 LTCLVWTTHPAQL----------TYTWY---------QDGQQRLDAHSIPLPNVTVRDAT 1145
+T + + P L W+ +D + + +D+
Sbjct: 1080 ITAALHS--PLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSG 1137
Query: 1146 SYRCGVGPPGRAPRLSRPITLDVLYAP--RNLRLTYLLESHGGQLALVLCTVDSRPPAQL 1203
Y C A R +++VL P N L +++ GQ A ++C V P +L
Sbjct: 1138 LYSCLAS--NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKL 1195
Query: 1204 ALSHAGRLLASSTAASV-PNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVR 1262
GR LA A + P+ + L++ G YSC A + +G+ +L
Sbjct: 1196 TWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQL-----S 1250
Query: 1263 VILAP------------EAAVPEGAPITVTCADPAAHAPTLYTWYHNG------RWLQEG 1304
V+LAP E V PI++ C A +P + TW +G R +Q
Sbjct: 1251 VLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNI-TWMKDGAPFEASRNIQLL 1309
Query: 1305 PAA-SLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP---QDAVLSSFR----D 1356
P L L A + AG Y+C + G + + ++VL P +D L+
Sbjct: 1310 PGTHGLQILNAQKEDAGQYTCVVTNELG-EAVKNYHVEVLIPPSISKDDPLAEVGVKEVK 1368
Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416
++ S ++C + PP + DG+ + SS + L G LQ+Q
Sbjct: 1369 TKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR----------LLQIQPT 1418
Query: 1417 PAGDD-TYVCTAQNLLGS--------------ISTIGRLQV--------EGARVVAEPGL 1453
D Y+C A N+ G +G E AR
Sbjct: 1419 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 1478
Query: 1454 DVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA-------EPVPTLAFTHVARAQA 1506
++ E L C P P W+ D+ L A + L V A
Sbjct: 1479 EIVENNPAYLYCDTNAIPPP----DLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENA 1534
Query: 1507 GMYHCLAELPTGAAASAPVMLRVLYPP----KTPTMMVFVEPEGGLRGILDCRVDSEPLA 1562
G Y C A G +L VL PP T ++ V L C P+
Sbjct: 1535 GRYSCKASNEVGEDWLHYELL-VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVP 1593
Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
++ S G P P + + + + +D Y+C A N GSA
Sbjct: 1594 TI----------SWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA 1643
Score = 149 bits (375), Expect = 3e-35
Identities = 309/1299 (23%), Positives = 445/1299 (34%), Gaps = 234/1299 (18%)
Query: 251 NILPGELVTLTCQVNSSYPAVSSIKWLKDG----------VRLQTKTGVLHLPQAAWSDA 300
++L G+ V L C+ + P + WLKDG +R G L L SDA
Sbjct: 1946 HVLEGQEVRLDCEADGQPPP--DVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA 2003
Query: 301 GVYTCQAENGVGS---------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNE 351
G YTC A N G LV P I + VS G + VT+VC
Sbjct: 2004 GAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGEL-----VTMVCPVRGS 2058
Query: 352 APSDLRYSWYKNHVLLE-------DAHSHTLRLHLATRADTGFYFCEVQNVHG-SERSGP 403
P + SW K+ + L HTLR+ AD G + C + G ++R+
Sbjct: 2059 PP--IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFT 2116
Query: 404 VSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP 463
+ V V P L PV E Q +V VV L L G L S D P
Sbjct: 2117 LQVQVP-PVLEPV-----EFQNDVV------VVRGSLVELPCEARGVPLPLVSWMKDGEP 2164
Query: 464 RFSGT--SGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEV 521
S + GP+ L++ + DSG Y C A + G A ++ P
Sbjct: 2165 LLSQSLEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQL------TVMEPPHIE 2215
Query: 522 VEGQAVTLSCRSGL--------SPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSY 573
GQ LS G TP +W+ +G L +S DAG Y
Sbjct: 2216 DSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLY 2275
Query: 574 HCRARDGHSASGPSSPAVLTV---LYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDP 630
C A A S + + PR P F L A + +L C V+++P
Sbjct: 2276 TCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGL--------APGQLVLECSVEAEP 2327
Query: 631 PARLQLLHKDRVVA-----TSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685
++ H+D +V T P G +++ + G
Sbjct: 2328 APKITW-HRDGIVLQEDAHTQFPERGRF--------------------LQLQALSTADSG 2366
Query: 686 LYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANF-SW 744
Y C A NA G STS F + + S N T + +A G PA SW
Sbjct: 2367 DYSCTARNAAG--STSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSW 2424
Query: 745 FRNGV-------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPD 797
++ V + P ++ + PV DA Y C AG+ L VL PP
Sbjct: 2425 RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDL-RVLEPPA 2483
Query: 798 RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEAN 857
+ L + AL C P L+ + L L G ++ +N
Sbjct: 2484 IAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL-----QQGAYRL-LPSN 2537
Query: 858 SLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQA------ 911
+L L G DS + C +N +G ++ R V V P + + Q
Sbjct: 2538 ALLLTAP--GPQDSAQFECVVSNEVGEAH-------RLYQVTVHVPPTIADDQTDFTVTM 2588
Query: 912 ---VVLSCQVHTGVPEGTSYRWYRDGQPL-------QESTSATLRFAAITLTQAGAYHCQ 961
VVL+C TG+P T W + G L + S S L AG Y C
Sbjct: 2589 MAPVVLTCH-STGIPAPT-VSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCS 2646
Query: 962 AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGD 1021
A+ + L V +P L +++ LL C P +
Sbjct: 2647 ARNSAGVAHK---HVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG 2703
Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081
VA+ + P G +L I A ED G Y+C A N+ G A
Sbjct: 2704 LNVATGVSTQVLPGG--------------QLRIAHASPEDAGNYLCIAKNSAGSAMGKTR 2749
Query: 1082 FDAQAVNV--QVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS------ 1133
Q V P + EG L C + +T W +DGQ A
Sbjct: 2750 LVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNIT--WDKDGQPVSGAEGKFTIQP 2807
Query: 1134 ---IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAP--------RNLRLTYLL- 1181
+ + N+ +DA +Y C R R + L +L P R+LRL L
Sbjct: 2808 SGELLVKNLEGQDAGTYTCTA--ENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLW 2865
Query: 1182 ---ESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGF 1238
+ G + TV+ RP + G A S D G
Sbjct: 2866 LRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVS-------------REDSGT 2912
Query: 1239 YSCSARSPLGQANTSLELRLEGVRVILAPEAAV---PEGAPITVTCADPAAHAPTLYTWY 1295
Y C A + +G+ + ++ V+ + P G I + C P ++ W
Sbjct: 2913 YVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIH-WI 2971
Query: 1296 HNG---------RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAP 1346
+G LQ G SL+ R AG Y C A++ G + + L + AP
Sbjct: 2972 KDGLPLRGSHLRHQLQNG---SLTIRRTERDDAGRYQCLAENEMGV-AKKVVILVLQSAP 3027
Query: 1347 QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVAR 1406
V R+ ++C EP + G+ L S + +L G+
Sbjct: 3028 VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGS------- 3080
Query: 1407 NALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQVEG 1444
L +++V GD TY C A NLLGS + L V G
Sbjct: 3081 ----LWLENVETGDAGTYDCVAHNLLGSATARAFLVVRG 3115
Score = 144 bits (362), Expect = 1e-33
Identities = 356/1523 (23%), Positives = 529/1523 (34%), Gaps = 293/1523 (19%)
Query: 250 RNILPGELVTLTCQVNSSYPAVSSIKWLK--------DGVRLQTKTGVLHLPQAAWSDAG 301
R I+ L C N+ P + W + D V + VL +P +AG
Sbjct: 1478 REIVENNPAYLYCDTNAIPPP--DLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAG 1535
Query: 302 VYTCQAENGVGS--------LVSPPISL---HIFMAEVQVSPAGPILENQTVTLVCNT-P 349
Y+C+A N VG +++PP+ L + EV V+ + TV+L C
Sbjct: 1536 RYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS------TVSLQCPALG 1589
Query: 350 NEAPSDLRYSWYKNHV---------LLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSER 400
N P+ SW +N + +LED L++ A AD Y C +N GS
Sbjct: 1590 NPVPT---ISWLQNGLPFSPSPRLQVLEDGQ--VLQVSTAEVADAASYMCVAENQAGSAE 1644
Query: 401 SGPVSVVVNHPPLTPVL-----TAFLETQAGLVGILHCSVVSEPL---ATLVLSHGGHIL 452
++ V PP L TA L + L +H E + LS G +
Sbjct: 1645 K-LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVF 1703
Query: 453 ASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR 512
P + L++ +DSG Y C A N+ G +
Sbjct: 1704 LL----------------PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLS----- 1742
Query: 513 LLISPAAE-----------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP----- 556
+L+ PA V G LSC + P P +WY +G L
Sbjct: 1743 VLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTV--TWYKDGQPLVLAQRTQAL 1800
Query: 557 --GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGA 614
G L + A +D G Y C+ + A LTV PP T AG+
Sbjct: 1801 RGGQRLEIQEAQVSDKGLYSCKV--SNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGS 1858
Query: 615 GAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRV 674
+L C V P + L KDR+ S G S G R+
Sbjct: 1859 PL----VLTCDVSGVPAPTVTWL-KDRMPVESSAVHGVVSRGG---------------RL 1898
Query: 675 EIHNPLLEEEGLYLCEASNALGNAS----TSATFNGQATVLAIAPSHTLQEGTEANLTCN 730
++ + G Y C A N A + + +A H + EG E L C
Sbjct: 1899 QLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC- 1957
Query: 731 VSREAAGSPA-NFSWFRNGVLWAQ--GPL-------ETVTLLPVARTDAALYACRILTEA 780
EA G P + +W ++G Q GP ++ L + +DA Y C A
Sbjct: 1958 ---EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPA 2014
Query: 781 G--AQLSTPVLLSVLYPPDRPKL---SALLDMGQGHMALFICTV-DSRPLALLALFHGEH 834
G A+L T ++VL PP + S L G + +C V S P+ + L G
Sbjct: 2015 GEDARLHT---VNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDG-- 2069
Query: 835 LLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894
L L + HG + L + ++ L D+G + C A + G ++ + QV
Sbjct: 2070 -LPLPLSQRTLLHG--------SGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV- 2119
Query: 895 GAWVQVSPSPELQE---------GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST---S 942
QV P E E G V L C+ GVP W +DG+PL +
Sbjct: 2120 ----QVPPVLEPVEFQNDVVVVRGSLVELPCEAR-GVPLPL-VSWMKDGEPLLSQSLEQG 2173
Query: 943 ATLRFAAITLTQAGAYHCQA-----QAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP 997
+L+ A+ +G Y C A +A ++ P + S P ++LT P
Sbjct: 2174 PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLT------P 2227
Query: 998 GRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGA 1057
G LLC P + H D + L+ + + A LR+
Sbjct: 2228 GAPMELLCDAQGTPQPNITW-HKDGQALTRLE------------NNSRATRVLRVR---- 2270
Query: 1058 MLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGAT-----VREGQLVNLTCLVWTT 1112
D G+Y C A + G S QA V P + GQLV L C V
Sbjct: 2271 ---DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSV-EA 2325
Query: 1113 HPAQLTYTWYQDG-QQRLDAHS--------IPLPNVTVRDATSYRC----GVGPPGRAPR 1159
PA TW++DG + DAH+ + L ++ D+ Y C G A R
Sbjct: 2326 EPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2384
Query: 1160 LSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGR--LLASSTA 1217
+ + P + ++ Q AL+ C D PA L R L S
Sbjct: 2385 VEIHTVPTIRSGPPAVNVSV------NQTALLPCQADG-VPAPLVSWRKDRVPLDPRSPR 2437
Query: 1218 ASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPI 1277
+ L ++ +D G Y C A + G +LR +L P A P + +
Sbjct: 2438 FEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR------VLEPPAIAPSPSNL 2491
Query: 1278 TVTCADPA-------AHAPTLYTWYHNGRWL----QEG-----PAASLSFLVATRAHAGA 1321
T+T PA L W+ +G+ L Q+G P+ +L +
Sbjct: 2492 TLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQ 2551
Query: 1322 YSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMA--VIQCTVDSEPPAELAL 1379
+ C + G QV + D MA V+ C P ++
Sbjct: 2552 FECVVSNEVGEAHR---LYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSW 2608
Query: 1380 SHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGR 1439
S G L A G+G+ AL + Q +P Y C+A+N G
Sbjct: 2609 SKAGAQLG--------ARGSGYRVSPSGALEIG-QALPIHAGRYTCSARNSAGVAHKHVF 2659
Query: 1440 LQVEGARVVAEPGLDVPEGAA---LNLSCRLLGGPGPVGNSTFAWFWNDRRL------HA 1490
L V+ + VV +P V A + L C G P P T W +
Sbjct: 2660 LTVQASPVV-KPLPSVVRAVAEEEVLLPCEASGIPRP----TITWQKEGLNVATGVSTQV 2714
Query: 1491 EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRG 1550
P L H + AG Y C+A+ G+A L V PP + + G
Sbjct: 2715 LPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGK-TRLVVQVPPVIENGLPDLSTTEGSHA 2773
Query: 1551 ILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGE 1610
L C+ P ++T + V+ AE + S L ++ L D G
Sbjct: 2774 FLPCKARGSPEPNITWDKDGQPVSG-------AEGKFTIQPSGELL---VKNLEGQDAGT 2823
Query: 1611 YICSASNVLGSASTSTYFGVRAL 1633
Y C+A N +G A + + L
Sbjct: 2824 YTCTAENAVGRARRRVHLTILVL 2846
Score = 124 bits (311), Expect = 8e-28
Identities = 264/1141 (23%), Positives = 404/1141 (35%), Gaps = 168/1141 (14%)
Query: 188 SQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSP 247
SQ+ G GH TL ++ I C + A LQV+ P +L
Sbjct: 2075 SQRTLLHGSGH--TLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPP----VLEPV 2128
Query: 248 SGRN---ILPGELVTLTCQVNS-SYPAVSSIKWLKDGVRLQTKT----GVLHLPQAAWSD 299
+N ++ G LV L C+ P VS W+KDG L +++ L L D
Sbjct: 2129 EFQNDVVVVRGSLVELPCEARGVPLPLVS---WMKDGEPLLSQSLEQGPSLQLEAVGAGD 2185
Query: 300 AGVYTCQAENGVG--------SLVSPPISLHIFMA----EVQVSPAGPILENQTVTLVCN 347
+G Y+C A + G +++ PP HI + E+ ++P P+ L+C+
Sbjct: 2186 SGTYSCVAVSEAGEARRHFQLTVMEPP---HIEDSGQPTELSLTPGAPM------ELLCD 2236
Query: 348 TPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGS-ERSGPVSV 406
++ +W+K+ L +++ + D G Y C ++ G+ E+S V V
Sbjct: 2237 AQGTPQPNI--TWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRV 2294
Query: 407 VVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466
+ P F+ A +L CSV +EP + G +L +
Sbjct: 2295 QAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAH--------- 2345
Query: 467 GTSGPNSLR-LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLIS--PAAEVVE 523
T P R L+++ L DSG+Y C+A N+ G+ + + + S PA V
Sbjct: 2346 -TQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSV 2404
Query: 524 GQAVTLSCRSGLSPTPDARFSWYLNGALLHEG-------PGSSLLLPAASSTDAGSYHCR 576
Q L C++ P P SW + L P SL + + DAG Y C
Sbjct: 2405 NQTALLPCQADGVPAP--LVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCL 2462
Query: 577 ARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQL 636
A +SA L VL PP + L L A LL C P +
Sbjct: 2463 A--SNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPA-----LLPCEASGSPKPLVVW 2515
Query: 637 LHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG 696
+ + L G ++ + LL + P ++ + C SN +G
Sbjct: 2516 WKDGQKLDFRLQQGA-----------YRLLPSNALL---LTAPGPQDSAQFECVVSNEVG 2561
Query: 697 NAST--SATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNGV---- 749
A T + T+ T+ LTC+ + G PA SW + G
Sbjct: 2562 EAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCH----STGIPAPTVSWSKAGAQLGA 2617
Query: 750 ------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSA 803
+ G LE LP+ A Y C AG V L+V P L +
Sbjct: 2618 RGSGYRVSPSGALEIGQALPI---HAGRYTCSARNSAGVA-HKHVFLTVQASPVVKPLPS 2673
Query: 804 LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
++ L C P + +AT + QV G+ L +
Sbjct: 2674 VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ-----------LRI 2722
Query: 864 RELGLGDSGSYRCEATNVLGSS--NTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTG 921
D+G+Y C A N GS+ T L QV P EG L C+ G
Sbjct: 2723 AHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKAR-G 2781
Query: 922 VPEGTSYRWYRDGQPLQEST-------SATLRFAAITLTQAGAYHCQAQAPGSATTSLAA 974
PE + W +DGQP+ + S L + AG Y C A+ +A
Sbjct: 2782 SPE-PNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAE---NAVGRARR 2837
Query: 975 PISLHVSYAPRHVTLTTLMDTGPGRLG---LLLCRVDSDPPAQLRLLHGDRLVASTLQGV 1031
+ L + P TTL RLG L C P ++ DR V +GV
Sbjct: 2838 RVHLTILVLP---VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT---EGV 2891
Query: 1032 GGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF---DAQAVN 1088
+G S AV+ ED G Y+C A N +G+ A + +A +
Sbjct: 2892 SEQDGGSTLQRAAVSR------------EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQ 2939
Query: 1089 VQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH---SIPLPNVTVR--- 1142
+ + G + L C+V + W +DG +H + ++T+R
Sbjct: 2940 GEAFSYLVEPVGGSIQLDCVVRGDPVPDIH--WIKDGLPLRGSHLRHQLQNGSLTIRRTE 2997
Query: 1143 --DATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRP 1199
DA Y+C G A ++ + L + AP + G + C P
Sbjct: 2998 RDDAGRYQCLAENEMGVAKKV---VILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEP 3054
Query: 1200 PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE 1259
+ AG+ L +S L L + D G Y C A + LG A L +
Sbjct: 3055 TPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3114
Query: 1260 G 1260
G
Sbjct: 3115 G 3115
Score = 75.9 bits (185), Expect = 3e-13
Identities = 210/931 (22%), Positives = 327/931 (35%), Gaps = 140/931 (15%)
Query: 768 DAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALL 827
D+ LY+CR +AG LL VL PP ++L G L + D
Sbjct: 98 DSGLYSCRAENQAGTAQRDFHLL-VLTPP------SVLGAGAAQEVLGLAGADVELQCWT 150
Query: 828 ALFHGEHLLATS-LGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN 886
+ + T P +P Q + + L++ +G D G Y+C A + G
Sbjct: 151 SGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSPAGQQA 208
Query: 887 TSLFFQVRGA---W-VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTS 942
+V W + + E V L C+ GVP + W++DG L ST
Sbjct: 209 RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEAR-GVPT-PNITWFKDGALLPTSTK 266
Query: 943 AT-------LRFAAITLTQAGAYHCQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMD 994
L+ + AG Y C+A A G+A + + Y P +
Sbjct: 267 VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-----YVPPTIE------ 315
Query: 995 TGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEI 1054
G G ++ V P A + G + G P S + + LRLE
Sbjct: 316 -GAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLES 374
Query: 1055 HGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHP 1114
G G+Y C AS+ G+A +V VQV P V EG L +T +V P
Sbjct: 375 PGEA--SSGLYSCVASSPAGEAVLQ-----YSVEVQVPPQLLVAEG-LGQVTTIVG--QP 424
Query: 1115 AQL----------TYTWYQDG---------QQRLDAHSIPLPNVTVRDATSYRCGVGPPG 1155
+L T W Q+G Q ++ + +V + + + C
Sbjct: 425 LELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 484
Query: 1156 RAPRLSRPITLDVLYAPRNLRLT-----YLLESHGGQLALVLCTVDS------RPPAQLA 1204
+++ +AP L + + E H A V +PP
Sbjct: 485 GTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEG 544
Query: 1205 LSHAGRLLASSTAASVPNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVR 1262
G L T V +L L++ RDEG Y+C+A + G++ + L+
Sbjct: 545 WCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALK----- 599
Query: 1263 VILAPEA-------AVPEGAPITVTCADPAAHAPTLYTWYHNGR----WLQEGPAASLSF 1311
V++ P AV E A +T+ C P + +W+ + W+ G S+
Sbjct: 600 VLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDV-SWFKGHQPVSSWM--GVTVSVDG 656
Query: 1312 LV-----ATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV-I 1365
V A + AG+Y C A + G+ R L+V P+ + S + V +
Sbjct: 657 RVLRIEQAQLSDAGSYRCVASNVAGSTELR-YGLRVNVPPRITLPPSLPGPVLVNTPVRL 715
Query: 1366 QCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYV 1424
C P L DG ++ + GT +QV L + A D Y
Sbjct: 716 TCNATGAPSPTLMWLKDGNPVSPA--------GTPGLQVFPGGRVLTLASARASDSGRYS 767
Query: 1425 CTAQNLLGSISTIGRLQVEGARVVA--EPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWF 1482
C A + +G LQV + E + V ++ L C+ P PV +W+
Sbjct: 768 CVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV----LSWW 823
Query: 1483 WNDRRLHAEPVPTL----AFTHVARAQ---AGMYHCLAELPTGAAA---SAPVMLRVLYP 1532
+ R L P L A V RA AG Y C A G + + V + ++P
Sbjct: 824 KDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFP 883
Query: 1533 PKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLAS 1592
+ + E G L C P ++ QP HV A
Sbjct: 884 LRESHTLTVRE---GHPTRLSCECRGVPFPKISWR------KDGQPLPGEGAGLQHVSAV 934
Query: 1593 PNALRVDIEALRPSDQGEYICSASNVLGSAS 1623
L + L + +G Y C SNV+G++S
Sbjct: 935 GRLLYLGQAQL--AQEGTYTCECSNVVGNSS 963
Score = 73.2 bits (178), Expect = 2e-12
Identities = 153/634 (24%), Positives = 215/634 (33%), Gaps = 104/634 (16%)
Query: 1061 DEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVRE------GQLVNLTCLVWTTHP 1114
D G+Y C A N G +A DF + GA + G V L C WT+
Sbjct: 98 DSGLYSCRAENQAG--TAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQC--WTSGV 153
Query: 1115 AQLTYTWYQDGQQRL----------DAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPI 1164
W +D Q L D + + V D Y+C P A + +R
Sbjct: 154 PTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP--AGQQARDF 211
Query: 1165 TLDV-----LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAAS 1219
L V ++ ++E H L +LC P + G LL +ST
Sbjct: 212 QLRVHAPPTIWGSNETGEVAVMEDH---LVQLLCEARGVPTPNITWFKDGALLPTSTKVV 268
Query: 1220 VPNTLR-LELRGPQPRDEGFYSCSARSPLGQANTSLELRL--------EGVRVILAPEAA 1270
R L+L Q D G Y+C A + +G A + L + G R + A
Sbjct: 269 YTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA 328
Query: 1271 VPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVAT-------RAHAGAYS 1323
G P+ + C +PTL +W+H G + E + L + A +G YS
Sbjct: 329 ---GRPVALECVARGHPSPTL-SWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYS 384
Query: 1324 CQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDG 1383
C A G + +++V PQ V Q T P EL G
Sbjct: 385 CVASSPAG-EAVLQYSVEVQVPPQLLVAEGLG----------QVTTIVGQPLELPCQASG 433
Query: 1384 KVLATSSGVHS--LASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRL 1440
+ T + + A VQVA L + V + C A N G+ +
Sbjct: 434 SPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEV 493
Query: 1441 QVEGARVVAEPG-LDVPEG-------------AALNLSCRLLGGPGPVGNSTFAWFWNDR 1486
V G PG L+VP G AA + G P W +
Sbjct: 494 SVHGEWA---PGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWC-SPG 549
Query: 1487 RLHAEPV---------PTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPT 1537
L EP P L V G+Y C A G + V L+VL PP
Sbjct: 550 SLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGES-KREVALKVLVPPNIEP 608
Query: 1538 MMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALR 1597
V L+C P ++ G + V+S + V S +
Sbjct: 609 GPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSS----------WMGVTVSVDGRV 658
Query: 1598 VDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
+ IE + SD G Y C ASNV G ST +G+R
Sbjct: 659 LRIEQAQLSDAGSYRCVASNVAG--STELRYGLR 690
Score = 58.9 bits (141), Expect = 4e-08
Identities = 98/436 (22%), Positives = 148/436 (33%), Gaps = 72/436 (16%)
Query: 1232 QPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVP----EGAPITVTCADPAAH 1287
Q D G YSC A + G A L + +L AA GA + + C
Sbjct: 95 QEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVP 154
Query: 1288 APTLYTWYHNGRWLQEGPAASLS----FLVATRAHAG---AYSCQAQDAQGTRSSRPAAL 1340
P + L GP + L T +H G Y C A G + +R L
Sbjct: 155 TPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAG-QQARDFQL 213
Query: 1341 QVLYAPQDAVLSSFRDSRARSMAVIQ-------CTVDSEPPAELALSHDGKVLATSSGVH 1393
+V P + + + +AV++ C P + DG +L TS+ V
Sbjct: 214 RVHAPP-----TIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVV 268
Query: 1394 SLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPG- 1452
G +Q+ R Q AG Y C A N +G+ RL V + G
Sbjct: 269 YTRGGR-QLQLGR------AQSSDAG--VYTCKASNAVGAAEKATRLDVYVPPTIEGAGG 319
Query: 1453 ----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFW--------NDRRLHAEPVPTLAFTH 1500
+ G + L C G P P T +W N+ RL + L
Sbjct: 320 RPYVVKAVAGRPVALECVARGHPSP----TLSWHHEGLPVAESNESRLETDG-SVLRLES 374
Query: 1501 VARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI------LDC 1554
A +G+Y C+A P G A +L+ + P ++ E G + I L C
Sbjct: 375 PGEASSGLYSCVASSPAGEA-----VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPC 429
Query: 1555 RVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICS 1614
+ P+ ++ G PAE V + + I+ + G + C
Sbjct: 430 QASGSPVPTIQW----------LQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQ 479
Query: 1615 ASNVLGSASTSTYFGV 1630
A+N G+A V
Sbjct: 480 ATNEAGTAGAEVEVSV 495
Score = 50.4 bits (119), Expect = 1e-05
Identities = 90/346 (26%), Positives = 129/346 (37%), Gaps = 54/346 (15%)
Query: 1299 RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSR 1358
R L EG SL F +G YSC+A++ GT + R L VL P +VL +
Sbjct: 81 RLLDEGQ--SLHFPRIQEGDSGLYSCRAENQAGT-AQRDFHLLVLTPP--SVLGAGAAQE 135
Query: 1359 ARSMA----VIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQ 1414
+A +QC P ++ + D + + G H+QV + L++
Sbjct: 136 VLGLAGADVELQCWTSGVPTPQVEWTKDRQ---------PVLPGGPHLQVQEDGQVLRIT 186
Query: 1415 DVPAGDD-TYVCTAQNLLGSISTIGRLQVEGARVV---AEPG-LDVPEGAALNLSCRLLG 1469
GD+ Y C A + G + +L+V + E G + V E + L C G
Sbjct: 187 GSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARG 246
Query: 1470 GPGPVGNSTFAWFWNDRRLHAEPVPT-LAFT------HVARAQ---AGMYHCLAELPTGA 1519
P P WF + L P T + +T + RAQ AG+Y C A GA
Sbjct: 247 VPTP----NITWFKDGALL---PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA 299
Query: 1520 AASAPVMLRVLYPPK---TPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASS 1576
A A L V PP V+ G L+C P +L+ H VA S
Sbjct: 300 AEKA-TRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAES 358
Query: 1577 QPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
+ + L SP + G Y C AS+ G A
Sbjct: 359 NESRLETDGSVLRLESPG----------EASSGLYSCVASSPAGEA 394
Score = 47.4 bits (111), Expect = 1e-04
Identities = 82/328 (25%), Positives = 119/328 (36%), Gaps = 37/328 (11%)
Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159
LL+K+L+ +D+G+Y E + V T++ + P T+ L G +
Sbjct: 2811 LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL---PVFTTLPGDRSLRLGDRLWLR 2867
Query: 160 CSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQL 219
C+ R+ W D R VT E G L+ A+S +D G + C
Sbjct: 2868 CAARG---SPTPRIGWTVND--RPVTEGVS--EQDGGSTLQ--RAAVSREDSGTYV-CWA 2917
Query: 220 SVANHRAQSEIHLQVKYAP----KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIK 275
R Q+ + VK AP + L+ P G +I L C V V I
Sbjct: 2918 ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSI------QLDCVVRGD--PVPDIH 2969
Query: 276 WLKDGVRL-------QTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEV 328
W+KDG+ L Q + G L + + DAG Y C AEN +G I +
Sbjct: 2970 WIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVF 3029
Query: 329 QVSPAG-PILENQTVTLVCNTPNEAPSDLRYSWYKNHVL----LEDAHSHTLRLHLATRA 383
QV P + V L C E + + + L +L L
Sbjct: 3030 QVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETG 3089
Query: 384 DTGFYFCEVQNVHGSERSGPVSVVVNHP 411
D G Y C N+ GS + VV P
Sbjct: 3090 DAGTYDCVAHNLLGSATARAFLVVRGEP 3117
Score = 37.4 bits (85), Expect = 0.13
Identities = 69/298 (23%), Positives = 102/298 (34%), Gaps = 59/298 (19%)
Query: 1365 IQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNAL-----RLQVQDVPAG 1419
++C + P E+ D +++ G G QV + L L + G
Sbjct: 38 LECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEG 97
Query: 1420 DD-TYVCTAQNLLGSISTIGRL------QVEGARVVAEP-GLDVPEGAALNLSCRLLGGP 1471
D Y C A+N G+ L V GA E GL GA + L C G P
Sbjct: 98 DSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGL---AGADVELQCWTSGVP 154
Query: 1472 GPVGNSTFAWFWNDRRLHAEP------------VPTLAFTHVARAQAGMYHCLAELPTGA 1519
P W R P V + +HV G Y C+A P G
Sbjct: 155 TPQVE------WTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSPAGQ 206
Query: 1520 AASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILD-------CRVDSEPLASLTLHLGSRL 1572
A LRV PP ++ E G +++ C P ++T L
Sbjct: 207 QAR-DFQLRVHAPPT-----IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGAL 260
Query: 1573 VASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGV 1630
+ +S V+ + ++ + + SD G Y C ASN +G+A +T V
Sbjct: 261 LPTSTK----------VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 308
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 201 bits (511), Expect = 5e-51
Identities = 332/1499 (22%), Positives = 559/1499 (37%), Gaps = 228/1499 (15%)
Query: 255 GELVTLTCQVNSSYPAVSSIKWLKDGVRL--------QTKTGV--LHLPQAAWSDAGVYT 304
GE TL C+V+ + P + I W K+ +L Q K V L + + SD G Y+
Sbjct: 7034 GEPATLQCKVDGT-PEIR-ISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYS 7091
Query: 305 CQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQT----------VTLVCNTPNEAPS 354
C+A+N VG++ S + + ++ P + V C P
Sbjct: 7092 CKADNSVGAVASSAVLV------IKARKLPPFFARKLKDVHETLGFPVAFECRINGSEP- 7144
Query: 355 DLRYSWYKNHVLLED--------AHS-HTLRLHLATRADTGFYFCEVQNVHGSERSGPVS 405
L+ SWYK+ VLL+D H+ TL++ ++ G Y C N G+ S
Sbjct: 7145 -LQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKL 7203
Query: 406 VVVNH--PPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP 463
++ H PP + ++ G G C V + A + +
Sbjct: 7204 ILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITW-------AKDNREIRPGG 7256
Query: 464 RFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLIS---PAAE 520
+ T N+ L + + + D+G+Y C A+N G + + I P+
Sbjct: 7257 NYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRI 7316
Query: 521 VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPG---------SSLLLPAASSTDAG 571
V + + C+ G SP + + WY + + E + L + S D+G
Sbjct: 7317 VKQDEFTRYECKIGGSP--EIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSG 7374
Query: 572 SYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPP 631
Y C A H+A+G +S + T L P F + GA L C + PP
Sbjct: 7375 DYTCEA---HNAAGSASSS--TSLKVKEPPIFRKKPHPIETLKGADVH--LECELQGTPP 7427
Query: 632 ARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEA 691
+ +KD+ L SG + K+ L + I N + G Y C+A
Sbjct: 7428 FHVSW-YKDK---RELRSG----------KKYKIMSENFLTSIHILNVDAADIGEYQCKA 7473
Query: 692 SNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFRN---- 747
+N +G+ + + +A + + + + E A P + WF++
Sbjct: 7474 TNDVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGA-EPISVVWFKDKGEI 7532
Query: 748 ----GVLWAQGPLETVTLLPVARTD---AALYACRILTEAGAQLSTPVLLSVLYPPDRPK 800
+W E + L +R + A Y C+I +AG Q LSVL P +
Sbjct: 7533 VRESDNIWISYS-ENIATLQFSRVEPANAGKYTCQIKNDAGMQ-ECFATLSVLEPATIVE 7590
Query: 801 LSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLK 860
+ + G CTV P F G ++ S +++
Sbjct: 7591 KPESIKVTTGDTCTLECTVAGTPELSTKWFKD--------GKELTSDNKYKISFFNKVSG 7642
Query: 861 LEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE-----GQAVVLS 915
L++ + DSG Y E N +G + + QV V S + +L+E G +VV+
Sbjct: 7643 LKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVME 7702
Query: 916 CQVHTGVPEGTSYRWYRDGQPLQES----TSATLRFAAITL-----TQAGAYHCQAQAPG 966
C+V+ P S W+ +G + T+ T A+T+ + +G Y C A
Sbjct: 7703 CKVYGSPPISVS--WFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNM- 7759
Query: 967 SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVAS 1026
+ + +AP++ V P V MD G V PP + G +
Sbjct: 7760 AGSDECSAPLT--VREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVP 7817
Query: 1027 TLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF--DA 1084
R +V++ + LE+ G Y C SN G+AS + A
Sbjct: 7818 -----------GDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKA 7866
Query: 1085 QAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDG-----QQRLDAHS------ 1133
A V+ ++ +G+ + L T P ++ TW ++G QR + +
Sbjct: 7867 PAKFVKRLNDYSIEKGKPLILEGTFTGTPP--ISVTWKKNGINVTPSQRCNITTTEKSAI 7924
Query: 1134 IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLC 1193
+ +P+ TV DA Y C + S I +L P ++ ++ G A + C
Sbjct: 7925 LEIPSSTVEDAGQYNCYIENASGKDSCSAQIL--ILEPPYFVKQLEPVKVSVGDSASLQC 7982
Query: 1194 TVDSRPPAQLALSHAGRLLASSTAASVP---NTLRLELRGPQPRDEGFYSCSARSPLGQA 1250
+ P ++ L +T + N L D G Y C A + +G+
Sbjct: 7983 QLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEV 8042
Query: 1251 NTSLELRLEGVRVILAPEAAVPE-----GAPITVTCADPAAHAPTLYTWYHNGRWLQEGP 1305
+ S L ++ ++ + + + G P+ CA + P +WY +G+ L++ P
Sbjct: 8043 SASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSE-PISVSWYKDGKPLKDSP 8101
Query: 1306 AASLSFLVAT---------RAHAGAYSCQAQDAQGTRSS----------RPAALQVLYAP 1346
SFL T R+ AG YSC A + G+ SS P + AP
Sbjct: 8102 NVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAP 8161
Query: 1347 QDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVAR 1406
DAV+ D +C V P +++ + D + + + G +
Sbjct: 8162 VDAVVGESAD--------FECHVTGTQPIKVSWAKDSREIRSG--------GKYQISYLE 8205
Query: 1407 NALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQVEGARVVAE------PGLDVPEGA 1459
N+ L V V GD Y C A N +G S +L ++ + ++ EG
Sbjct: 8206 NSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGN 8265
Query: 1460 ALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTH------VARA---QAGMYH 1510
+ L R+ G P+ T AW+ N+ + + F + V +A AG+Y
Sbjct: 8266 SFKLEGRVAGSQ-PI---TVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYT 8321
Query: 1511 CLAELPTGAA--ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVD-SEPLASLTLH 1567
C G+A S+ V+ PP + V G L C V SEP+ L
Sbjct: 8322 CKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLK 8381
Query: 1568 LGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTST 1626
G + P++ AS A+ +++ + +D G+Y+C ASNV GS +T +
Sbjct: 8382 AGREI--------KPSDRCSFSFASGTAV-LELRDVAKADSGDYVCKASNVAGSDTTKS 8431
Score = 186 bits (472), Expect = 2e-46
Identities = 357/1650 (21%), Positives = 601/1650 (36%), Gaps = 239/1650 (14%)
Query: 102 LKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCS 161
+ D++ EDSGSY+ +++V SD T + + E P P +++ GT C
Sbjct: 3797 ITDVKVEDSGSYSCE-AVNDVG--SDSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCE 3853
Query: 162 TPYVCLQEQVRLQW-QGQDPARSVTFNSQKFEPTGVGHLETLHM-AMSWQDHGRILRCQL 219
V + W + + RS S+K+ L L + + + D G +
Sbjct: 3854 ---VSGTGPFEISWFKDKKQIRS----SKKYRLFSQKSLVCLEIFSFNSADVGEY---EC 3903
Query: 220 SVANHRAQS---EIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW 276
VAN + HL +K P VK + L G+ VTL V S P S+ W
Sbjct: 3904 VVANEVGKCGCMATHL-LKEPPTFVKKV---DDLIALGGQTVTLQAAVRGSEPI--SVTW 3957
Query: 277 LK-------DG-VRLQTKTGV--LHLPQAAWSDAGVYTCQAENGVGS-------LVSPPI 319
+K DG +++ GV L +P S G YTC AEN GS +V P
Sbjct: 3958 MKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPA 4017
Query: 320 SLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHT----- 374
+ +QV+ P TV TP +L+ WYK+ L + +
Sbjct: 4018 KIIERAELIQVTAGDPATLEYTVA---GTP-----ELKPKWYKDGRPLVASKKYRISFKN 4069
Query: 375 ----LRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVG- 429
L+ + A D+G Y E+ N GS V++ + P T L +V
Sbjct: 4070 NVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRD-IAPFFTKPLRNVDSVVNG 4128
Query: 430 --ILHCSVV-SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDS 486
L C + S P+ G I AS D GT+ LEI ++ D+
Sbjct: 4129 TCRLDCKIAGSLPMRVSWFKDGKEIAAS---DRYRIAFVEGTAS-----LEIIRVDMNDA 4180
Query: 487 GEYKCSATNSLGNATST--LDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFS 544
G + C ATNS+G+ S+ L + + + +V+ G AV L +S +
Sbjct: 4181 GNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCL--KSTFQGSTPLTIR 4238
Query: 545 WYLNGALLHEGPG---------SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVL 595
W+ L G SSL L ++D+G+Y C+ + A G A L V
Sbjct: 4239 WFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKV--SNVAGGVECSANLFVK 4296
Query: 596 YPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCST 655
P TF +L+ + G L C+V PP ++ DR + S
Sbjct: 4297 EP---ATFVEKLE-PSQLLKKGDATQLACKVTGTPPIKITWFANDREIKES--------- 4343
Query: 656 CGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATF---NGQATVLA 712
RM ++ +LR + + +E+ G Y+CEA N G+ S+
Sbjct: 4344 ---SKHRMSFVESTAVLR--LTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKE 4398
Query: 713 IAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNGVL---------WAQGPLETVTLL 762
P L+E L E AG+P +WF++ + + Q L ++ +L
Sbjct: 4399 FKPIEVLKEYDVMLLA-----EVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQIL 4453
Query: 763 PVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTV-DS 821
DA Y CR+ E G+ + + +++ PP K +G A F T+ S
Sbjct: 4454 KFVAADAGEYQCRVTNEVGSSICS-ARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGS 4512
Query: 822 RPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNV 881
P+ + L + ++ + E N L + + + G Y C+A N
Sbjct: 4513 LPITVTWLKDSD---------EITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKND 4563
Query: 882 LGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQ--- 938
G S V+ + + Q + QV + + +W++DGQ L
Sbjct: 4564 AGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGS 4623
Query: 939 ------ESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTL 992
T + L+ + +G Y + Q ++ A L + P
Sbjct: 4624 KYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKK 4683
Query: 993 MDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRL 1052
MD+ G L C V P ++ D+ ++ +S + + NT L
Sbjct: 4684 MDSIKGSFIDLECIVAGSHPISIQWFKDDQEIS-----------ASEKYKFSFHDNTAFL 4732
Query: 1053 EIHGAMLEDEGVYICEASNTLG--QASASADFDAQAVNVQVWPGATVREGQLVNLTCLVW 1110
EI D G Y C A+N G Q S V+ V V L LV
Sbjct: 4733 EISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVG 4792
Query: 1111 TTHPAQLTYTWYQDGQQRLD-----------AHSIPLPNVTVRDATSYRCGVGPPGRAPR 1159
T P +T W++D ++ + S+ L D+ +Y C +
Sbjct: 4793 GTAP--MTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLS--NDVGT 4848
Query: 1160 LSRPITLDVLYAPRNLRL-TYLLESHGGQLALVLCTVDSRPPAQLALSHAGR---LLASS 1215
+ TL V P+ ++ + +L GQ C + P +++ G +
Sbjct: 4849 ATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKH 4908
Query: 1216 TAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGA 1275
+ + ++ G + + G Y C AR+ G A+ S+EL+++ P + E
Sbjct: 4909 GISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVK------EPPTFIRELK 4962
Query: 1276 PITVTC-------ADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVAT---------RAHA 1319
P+ V + P TW N R ++ +L+ V+ +
Sbjct: 4963 PVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDT 5022
Query: 1320 GAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRA--RSMAVIQCTVDSEPPAEL 1377
G Y C + G+ S + +V + + ++ +S A Q TV PP +
Sbjct: 5023 GEYQCIVSNEGGSCS---CSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISI 5079
Query: 1378 ALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAG-DDTYVCTAQNLLGSIST 1436
D ++L V ++ + LQ++ V G Y C A+N G
Sbjct: 5080 TWLKDDQILDEDDNV--------YISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERC 5131
Query: 1437 IGRLQVEGARVVAE--PGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVP 1494
L V+ + E +DV E + L C + G P W + +++
Sbjct: 5132 YAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTP----ELKVKWLKDGKQIVPSRYF 5187
Query: 1495 TLAFTH---------VARAQAGMYHCLAELPTGAAASAPVMLRVL---YPPKTPTMMVFV 1542
+++F + V + +G Y E G ++S LRVL PP + +
Sbjct: 5188 SMSFENNVASFRIQSVMKQDSGQYTFKVENDFG-SSSCDAYLRVLDQNIPPSFTKKLTKM 5246
Query: 1543 EPEGGLRGILDCRVD-SEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIE 1601
+ G ++C+V S P+++ G + S++ ++ ++ +++
Sbjct: 5247 DKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAK---------YRLVCHERSVSLEVN 5297
Query: 1602 ALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
L D Y C SNV G + S V+
Sbjct: 5298 NLELEDTANYTCKVSNVAGDDACSGILTVK 5327
Score = 186 bits (472), Expect = 2e-46
Identities = 370/1748 (21%), Positives = 630/1748 (36%), Gaps = 274/1748 (15%)
Query: 27 QDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEARFRGR 86
+DV + G+ +++ C S A + V W+ D + ++VS PK +
Sbjct: 6748 KDVNAILGASVVLECRVSGSAPISVG------WFQDGN---EIVS---GPKC-------Q 6788
Query: 87 TEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIAS 146
+ F N VC L L L+P D+G Y ++ SD ++TV E P
Sbjct: 6789 SSFSEN----VCTLNLSLLEPSDTGIYTC---VAANVAGSDECSAVLTVQEPPSFEQTPD 6841
Query: 147 PVELLEGTEVDFNCSTPYVCLQEQVRLQW----QGQDPARSVTFNSQKFEPTGVGHLETL 202
VE+L G + F T + +++W + P S + + F V LE
Sbjct: 6842 SVEVLPGMSLTF---TSVIRGTPPFKVKWFKGSRELVPGESCNISLEDF----VTELELF 6894
Query: 203 HMA-MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLT 261
+ + D+ C ++ A HL VK VK L S + G + L
Sbjct: 6895 EVQPLESGDYS----CLVTNDAGSASCTTHLFVKEPATFVKRLADFS---VETGSPIVLE 6947
Query: 262 CQVNSSYPAVSSIKWLKD----------GVRLQTKTGVLHLPQAAWSDAGVYTCQAENGV 311
+ P S+ W+KD + + K+ +L + ++ D Y+C EN
Sbjct: 6948 ATYTGTPPI--SVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEA 7005
Query: 312 G--------SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKN 363
G S++ PP F+ ++ A + + TL C + ++R SWYK
Sbjct: 7006 GQDICEALVSVLEPPY----FIEPLEHVEA---VIGEPATLQCKV--DGTPEIRISWYKE 7056
Query: 364 HVLLEDAHSHTLR---------LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNH--PP 412
H L A ++ ++ ++ +D G Y C+ N G+ S V V+ PP
Sbjct: 7057 HTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLPP 7116
Query: 413 LTPVLTAFLETQAGLVGILHCSVV-SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGP 471
+ G C + SEPL G D++ F
Sbjct: 7117 FFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDG----VLLKDDANLQTSFVH---- 7168
Query: 472 NSLRLEIRDLEETDSGEYKCSATNSLGNATST----LDFHANAARLLISPAA-EVVEGQA 526
N L+I +++ G+Y CSA+N LG A+S+ L H + P + ++ G++
Sbjct: 7169 NVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGES 7228
Query: 527 VTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASST---------DAGSYHCRA 577
T C ++ T + +W + + G + L ++T DAG Y C A
Sbjct: 7229 GTFKCH--VTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYA 7286
Query: 578 RDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLL 637
+ A S A L V PPR F +L+ C++ P ++ L
Sbjct: 7287 --SNIAGKDSCSAQLGVQEPPR---FIKKLEPSRI-VKQDEFTRYECKIGGSPEIKV-LW 7339
Query: 638 HKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGN 697
+KD S + +++ ++ +E+HN +E+ G Y CEA NA G+
Sbjct: 7340 YKDETEIQE-------------SSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGS 7386
Query: 698 ASTSATFNGQATVLAIAPSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRNG------- 748
AS+S + + + H ++ +G + +L C + P + SW+++
Sbjct: 7387 ASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQ---GTPPFHVSWYKDKRELRSGK 7443
Query: 749 --VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLD 806
+ ++ L ++ +L V D Y C+ + G+ + P KLS +
Sbjct: 7444 KYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDIST 7503
Query: 807 MGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVREL 866
+ + L + P++++ G V N L+ +
Sbjct: 7504 VVGKEVQLQTTIEGAEPISVVWF--------KDKGEIVRESDNIWISYSENIATLQFSRV 7555
Query: 867 GLGDSGSYRCEATNVLGSSN--TSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPE 924
++G Y C+ N G +L V+ S ++ G L C V G PE
Sbjct: 7556 EPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTV-AGTPE 7614
Query: 925 GTSYRWYRDGQPLQESTS---------ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAP 975
S +W++DG+ L + L+ + + +G Y + Q P + A
Sbjct: 7615 -LSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTA-- 7671
Query: 976 ISLHVSYAPRHVTLTTLMDTGPGRLG---LLLCRVDSDPPAQLRLLHGDRLVASTLQGVG 1032
SL VS + T + G G ++ C+V PP + H G
Sbjct: 7672 -SLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFH-----------EG 7719
Query: 1033 GPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVN--VQ 1090
S + + NT L ++ D G Y C A+N G SA + VQ
Sbjct: 7720 NEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQ 7779
Query: 1091 VWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL-----------DAHSIPLPNV 1139
V G V T +V T P + +W++ + + + L +V
Sbjct: 7780 KPDPMDVLTGTNVTFTSIVKGTPP--FSVSWFKGSSELVPGDRCNVSLEDSVAELELFDV 7837
Query: 1140 TVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRP 1199
+ Y C V A + S L + + ++ G+ ++ T P
Sbjct: 7838 DTSQSGEYTCIVS--NEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTP 7895
Query: 1200 PAQLALSHAGRLLASSTAASVPNTLR---LELRGPQPRDEGFYSCSARSPLGQANTSLEL 1256
P + G + S ++ T + LE+ D G Y+C + G+ + S ++
Sbjct: 7896 PISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQI 7955
Query: 1257 RLEGVRVILAPEAAVPEGAPITVTCADPA------AHAPTL-YTWYHNGRWLQ------- 1302
+IL P V + P+ V+ D A A P + +WY L+
Sbjct: 7956 ------LILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKM 8009
Query: 1303 --EGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSF----RD 1356
A+L F +G Y C+A+++ G S A L + + SF RD
Sbjct: 8010 HFRNNVATLVFNQVDINDSGEYICKAENSVGEVS----ASTFLTVQEQKLPPSFSRQLRD 8065
Query: 1357 --SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVH-SLASGTGHVQVARNALRLQV 1413
V C + P ++ DGK L S V S T + + + L
Sbjct: 8066 VQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAG 8125
Query: 1414 QDVPAGDDTYVCTAQNLLGSISTIGRL-QVEGARV----VAEPGLDVPEGAALNLSCRLL 1468
Q Y CTA N +GS S+ RL EG + +D G + + C +
Sbjct: 8126 Q--------YSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVT 8177
Query: 1469 GGPGPVGNSTFAWFWNDRRL---------HAEPVPTLAFTHVARAQAGMYHCLAELPTG- 1518
G P+ +W + R + + E L V + +G Y C A G
Sbjct: 8178 -GTQPI---KVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGK 8233
Query: 1519 --AAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRV-DSEPLASLTLHLGSRLVAS 1575
A + R++ P T + VE G L+ RV S+P+ + +
Sbjct: 8234 DSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPT 8293
Query: 1576 SQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRALHR 1635
S + + N L + + +D G Y C SN GSA ++ ++ +
Sbjct: 8294 S---------NCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKK 8344
Query: 1636 LHQFQQLL 1643
F Q L
Sbjct: 8345 PPVFDQHL 8352
Score = 183 bits (464), Expect = 1e-45
Identities = 362/1735 (20%), Positives = 619/1735 (35%), Gaps = 234/1735 (13%)
Query: 26 PQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEARFRG 85
P V +KGS +++ C S EV +W D ++QV R
Sbjct: 6464 PSPVGALKGSDVILQCEISGTPPFEV------VWVKD---RKQV--------------RN 6500
Query: 86 RTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIA 145
+F +H +L + +L+ D G Y+ + +EV SD V E PR
Sbjct: 6501 SKKFKITSKHFDTSLHILNLEASDVGEYHCK-ATNEVG--SDTCSCSVKFKEPPRFVKKL 6557
Query: 146 SPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMA 205
S L G V+ V L+ +G+ V S+ + + ++ TL +
Sbjct: 6558 SDTSTLIGDAVELRAIVEGFQPISVVWLKDRGE-----VIRESENTRISFIDNIATLQLG 6612
Query: 206 MSWQDHGRILRCQL-SVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQV 264
+ CQ+ + A R S + ++ A +I+ P + G L C V
Sbjct: 6613 SPEASNSGKYICQIKNDAGMRECSAVLTVLEPA----RIIEKPEPMTVTTGNPFALECVV 6668
Query: 265 NSSYPAVSSIKWLKDGVRLQT----------KTGVLHLPQAAWSDAGVYTCQAENGVGSL 314
+ P +S+ KW KDG L K L +P A SD G+Y+ + +N VG
Sbjct: 6669 TGT-PELSA-KWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKS 6726
Query: 315 VSPPISLHIFMAEVQVSPAGPILE-----NQTVTLVCNTPNEAPSDLRYSWYKNHVL--- 366
+ +S+H+ V S + + +V L C AP + + N ++
Sbjct: 6727 -NCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGP 6785
Query: 367 -LEDAHSH---TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLE 422
+ + S TL L L +DTG Y C NV GS+ V + V PP +E
Sbjct: 6786 KCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAV-LTVQEPPSFEQTPDSVE 6844
Query: 423 TQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLE 482
G+ + P + G L + F LE+ +++
Sbjct: 6845 VLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFV-------TELELFEVQ 6897
Query: 483 ETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDAR 542
+SG+Y C TN G+A+ T + A+ + + + TP
Sbjct: 6898 PLESGDYSCLVTNDAGSASCTTHLFVKEPATFVKRLADFSVETGSPIVLEATYTGTPPIS 6957
Query: 543 FSWYLNGALLHEGPGSSLLLPAASST---------DAGSYHCRARDGHSASGPSSPAVLT 593
SW + L+ + S+ + S+ D Y C + A A+++
Sbjct: 6958 VSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIEN--EAGQDICEALVS 7015
Query: 594 VLYPPR--QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGG 651
VL PP +P L+ A G L C+VD P R+ + T L S
Sbjct: 7016 VLEPPYFIEP-------LEHVEAVIGEPATLQCKVDGTPEIRISWYKEH----TKLRS-- 7062
Query: 652 GCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVL 711
+P K+ N+ + I+ + G Y C+A N++G ++SA +A L
Sbjct: 7063 --------APAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKL 7114
Query: 712 AIAPSHTLQE-----GTEANLTCNVSREAAGSPANFSWFRNGVLWAQGP------LETVT 760
+ L++ G C ++ P SW+++GVL + V
Sbjct: 7115 PPFFARKLKDVHETLGFPVAFECRIN---GSEPLQVSWYKDGVLLKDDANLQTSFVHNVA 7171
Query: 761 LLPVARTDAA---LYACRILTEAGAQLSTPVLLSVLY--PPDRPKLSALLDMGQGHMALF 815
L + +TD + Y C G S+ L+ + PP +D+ G F
Sbjct: 7172 TLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTF 7231
Query: 816 ICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYR 875
C V + ++ G ++ N+ L V ++G GD+G Y
Sbjct: 7232 KCHVTGTAPIKITWAKDNR--------EIRPGGNYKMTLVENTATLTVLKVGKGDAGQYT 7283
Query: 876 CEATNVLGSSNTSLFFQVRGA---WVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYR 932
C A+N+ G + S V+ ++ PS +++ + C++ G PE WY+
Sbjct: 7284 CYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIG-GSPE-IKVLWYK 7341
Query: 933 DGQPLQESTS---------ATLRFAAITLTQAGAYHCQAQ-APGSATTSLAAPISLHVSY 982
D +QES+ A L +++ +G Y C+A A GSA++S SL V
Sbjct: 7342 DETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSST----SLKVKE 7397
Query: 983 APRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLH 1042
P ++T G L C + PP + R + S + E +H
Sbjct: 7398 PPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIH 7457
Query: 1043 VAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVN--VQVWPGATVREG 1100
+ L + A D G Y C+A+N +G + +A V+ + G
Sbjct: 7458 I--------LNVDAA---DIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTVVG 7506
Query: 1101 QLVNLTCLVWTTHPAQLTYTWYQDGQQRL------------DAHSIPLPNVTVRDATSYR 1148
+ V L + P ++ W++D + + + ++ V +A Y
Sbjct: 7507 KEVQLQTTIEGAEP--ISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYT 7564
Query: 1149 CGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHA 1208
C + A TL VL + ++ G + CTV P
Sbjct: 7565 CQI--KNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKD 7622
Query: 1209 GRLLASSTAASVP---NTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265
G+ L S + L++ P D G YS ++P+G+ + + L++ V
Sbjct: 7623 GKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPP 7682
Query: 1266 APEAAVPE-----GAPITVTCADPAAHAPTLYTWYHNGRWLQEGP---------AASLSF 1311
+ + E G+ + + C + P +W+H G + G +L+
Sbjct: 7683 SFTRKLKETNGLSGSSVVMECKVYGS-PPISVSWFHEGNEISSGRKYQTTLTDNTCALTV 7741
Query: 1312 LVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDS 1371
+ + +G Y+C A + G+ A L V P D + V
Sbjct: 7742 NMLEESDSGDYTCIATNMAGSDECS-APLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKG 7800
Query: 1372 EPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNL 1430
PP ++ L + V + + L++ DV Y C N
Sbjct: 7801 TPPFSVSWFKGSSELVPGDRCN--------VSLEDSVAELELFDVDTSQSGEYTCIVSNE 7852
Query: 1431 LGSISTIGRLQVEGARVVAEPGLD--VPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRL 1488
G S L ++ + D + +G L L G P P+ + W +
Sbjct: 7853 AGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTP-PISVT-----WKKNGI 7906
Query: 1489 HAEPVPTLAFTHVARA-----------QAGMYHCLAELPTGAAASAPVMLRVLYPPKTPT 1537
+ P T ++ AG Y+C E +G + + +L +L PP
Sbjct: 7907 NVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQIL-ILEPPYFVK 7965
Query: 1538 MMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALR 1597
+ V+ G L C++ P ++ + G + + ++ L +
Sbjct: 7966 QLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFN---Q 8022
Query: 1598 VDIEALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGL 1652
VDI +D GEYIC A N +G S ST+ V+ F + L + VGL
Sbjct: 8023 VDI-----NDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGL 8072
Score = 174 bits (442), Expect = 5e-43
Identities = 362/1729 (20%), Positives = 631/1729 (36%), Gaps = 258/1729 (14%)
Query: 24 SSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEARF 83
S P V+ +K + + + C S EV +WY D +RQ+ S S K+ F
Sbjct: 5521 SFPPIVETLKNAEVSLECELSGTPPFEV------VWYKD---KRQLRS-SKKYKIASKNF 5570
Query: 84 RGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPT 143
H ++L ++ D G Y+ + + +EV SD V + E PR +
Sbjct: 5571 -----------HTSIHIL--NVDTSDIGEYHCKAQ-NEVG--SDTCVCTVKLKEPPRFVS 5614
Query: 144 IASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLH 203
+ + ++ G + S + + +QW + V S+ T V ++ TL
Sbjct: 5615 KLNSLTVVAGEPAELQASIEGA---QPIFVQWLKEK--EEVIRESENIRITFVENVATLQ 5669
Query: 204 MAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQ 263
A + + CQ+ ++ L V + I+ + GE TL C+
Sbjct: 5670 FAKAEPANAGKYICQIKNDGGMRENMATLMVL---EPAVIVEKAGPMTVTVGETCTLECK 5726
Query: 264 VNSSYPAVSSIKWLKDGVRLQT----------KTGVLHLPQAAWSDAGVYTCQAENGVGS 313
V + P +S ++W KDG L + K L + DAG YT Q +N VG
Sbjct: 5727 VAGT-PELS-VEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGK 5784
Query: 314 LVSPPISLHIFMAEVQVSPA--------GPILENQTVTLVCNTPNEAPSDLRYSWYKNHV 365
+ + +++ V P+ G +L + L C +P + +W+
Sbjct: 5785 SSCTAV---VDVSDRAVPPSFTRRLKNTGGVLGASCI-LECKVAGSSP--ISVAWFHEKT 5838
Query: 366 LLEDAHSH---------TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPV 416
+ + TL+L+ +D G Y C NV GS+ V + V PP
Sbjct: 5839 KIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAV-LTVQEPPSFVK 5897
Query: 417 LTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRL 476
LE G + P + G L GD + F T L
Sbjct: 5898 EPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVK--GDRCNI-YFEDTVA----EL 5950
Query: 477 EIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAE--VVEGQAVTLSCRSG 534
E+ +++ + SGEY C +N+ G A+ T + ++ V G+++ L S
Sbjct: 5951 ELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILE--ST 6008
Query: 535 LSPTPDARFSWYLNGALLHEGPGSSL-------LLPAASST--DAGSYHCRARDGHSASG 585
+ T +W +G + ++ +L +ST DAG Y C + A
Sbjct: 6009 YTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIEN--EAGR 6066
Query: 586 PSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVAT 645
A+++ L PP T +L+ A G L C+V P + D +
Sbjct: 6067 DVCGALVSTLEPPYFVT-----ELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRP 6121
Query: 646 SLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFN 705
+ P + N+ + + + + G Y C+A N++G AS+ F
Sbjct: 6122 T--------------PEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFR 6167
Query: 706 GQATVLAIAPSHTLQE-----GTEANLTCNVSREAAGSPANFSWFRNGVLWAQGP----- 755
Q L + + L++ G LTC ++ A P W+R+GVL
Sbjct: 6168 IQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSA---PIQVCWYRDGVLLRDDENLQTS 6224
Query: 756 -LETVTLLPVARTD---AALYACRILTEAGAQLSTPVLLSVLYPPDRPKLS---ALLDMG 808
++ V L + +TD + Y+C G S+ L+ P P +D+
Sbjct: 6225 FVDNVATLKILQTDLSHSGQYSCSASNPLGTA-SSSARLTAREPKKSPFFDIKPVSIDVI 6283
Query: 809 QGHMALFICTVD-SRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELG 867
G A F C V ++P+ + + ++ G + N+ L + ++G
Sbjct: 6284 AGESADFECHVTGAQPM---------RITWSKDNKEIRPGGNYTITCVGNTPHLRILKVG 6334
Query: 868 LGDSGSYRCEATNVLGSSNTSLFFQVRGA---WVQVSPSPELQEGQAVVLSCQVHTGVPE 924
GDSG Y C+ATN +G S V+ ++ S ++G+++ L C++ +G PE
Sbjct: 6335 KGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKI-SGSPE 6393
Query: 925 GTSYRWYRDGQPLQESTSATLRF----AAITLTQA-----GAYHCQA-QAPGSATTSLAA 974
W+R+ L ES + F A +T+ +A G Y C+A G A+ S A
Sbjct: 6394 -IKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTA- 6451
Query: 975 PISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034
L V P + + G +L C + PP ++ + + V ++ +
Sbjct: 6452 ---LTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITS 6508
Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQ--ASASADFDAQAVNVQVW 1092
+ LH+ L LE D G Y C+A+N +G S S F V+
Sbjct: 6509 KHFDTSLHI------LNLE-----ASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKL 6557
Query: 1093 PGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL------------DAHSIPLPNVT 1140
+ G V L +V P ++ W +D + + + ++ L +
Sbjct: 6558 SDTSTLIGDAVELRAIVEGFQP--ISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPE 6615
Query: 1141 VRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPP 1200
++ Y C + S +T VL R + + G + C V P
Sbjct: 6616 ASNSGKYICQIKNDAGMRECSAVLT--VLEPARIIEKPEPMTVTTGNPFALECVVTGTPE 6673
Query: 1201 AQLALSHAGRLLASST---AASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLEL- 1256
GR L++ + + L++ + D+G YS ++ +G++N ++ +
Sbjct: 6674 LSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVH 6733
Query: 1257 ------------RLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEG 1304
+L+ V IL GA + + C + AP W+ +G + G
Sbjct: 6734 VSDRIVPPSFIRKLKDVNAIL--------GASVVLECR-VSGSAPISVGWFQDGNEIVSG 6784
Query: 1305 PAASLSF---------LVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR 1355
P SF + + G Y+C A + G+ A L V P
Sbjct: 6785 PKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGS-DECSAVLTVQEPPSFEQTPDSV 6843
Query: 1356 DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVH-SLASGTGHVQVARNALRLQVQ 1414
+ + PP ++ + L + SL +++ +VQ
Sbjct: 6844 EVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFVTELEL------FEVQ 6897
Query: 1415 DVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLD--VPEGAALNLSCRLLGGPG 1472
+ +GD Y C N GS S L V+ + D V G+ + L G P
Sbjct: 6898 PLESGD--YSCLVTNDAGSASCTTHLFVKEPATFVKRLADFSVETGSPIVLEATYTGTP- 6954
Query: 1473 PVGNSTFAWFWNDRRLHAEPVPTLAFTHVAR---------AQAGMYHCLAELPTGAAASA 1523
P+ + +W ++ + ++ T + Y CL E G
Sbjct: 6955 PI---SVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDI-C 7010
Query: 1524 PVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPA 1583
++ VL PP + VE G L C+VD P ++ + + S+
Sbjct: 7011 EALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSA------- 7063
Query: 1584 EPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRA 1632
P + N + I + SD GEY C A N +G+ ++S ++A
Sbjct: 7064 -PAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKA 7111
Score = 168 bits (425), Expect = 5e-41
Identities = 315/1464 (21%), Positives = 527/1464 (35%), Gaps = 241/1464 (16%)
Query: 94 EHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEG 153
E+ V + ++ + +DSG Y F+ E + D ++ P + ++ + G
Sbjct: 5192 ENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLG 5251
Query: 154 TEVDFNCSTPYVCLQEQVRLQW--QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDH 211
+ + C V + QW G++ + S + E + + L + +D
Sbjct: 5252 SSIHMECK---VSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLEL----EDT 5304
Query: 212 GRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAV 271
+VA A S I L VK P L+ P + +P V + + P
Sbjct: 5305 ANYTCKVSNVAGDDACSGI-LTVKEPP---SFLVKPGRQQAIPDSTVEFKAILKGTPP-- 5358
Query: 272 SSIKWLKDGVR----------LQTKTGVLHLPQAAWSDAGVYTCQAENGVGS-------L 314
IKW KD V L+ T L+L S G YTC N VGS L
Sbjct: 5359 FKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLL 5418
Query: 315 VSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH- 373
V+ P F+ +++ S + + L C ++R W++N L + +
Sbjct: 5419 VTEPPK---FVKKLEASKI--VKAGDSSRLECKIAGS--PEIRVVWFRNEHELPASDKYR 5471
Query: 374 --------TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQA 425
++++ + D+G + CE QN GS S V+V PP+ +ET
Sbjct: 5472 MTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGS-TSCSTKVIVKEPPVFSSFPPIVETLK 5530
Query: 426 GLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETD 485
L C + P +V L S S ++ S + I +++ +D
Sbjct: 5531 NAEVSLECELSGTPPFEVVWYKDKRQLRS-------SKKYKIASKNFHTSIHILNVDTSD 5583
Query: 486 SGEYKCSATNSLGNATSTLDFHANAARLLISP--AAEVVEGQAVTLSCR-SGLSP----- 537
GEY C A N +G+ T +S + VV G+ L G P
Sbjct: 5584 IGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQW 5643
Query: 538 ----------TPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPS 587
+ + R ++ N A +L A +AG Y C+ + +
Sbjct: 5644 LKEKEEVIRESENIRITFVENVA--------TLQFAKAEPANAGKYICQIK--NDGGMRE 5693
Query: 588 SPAVLTVLYPPRQPTFTTRLDLDAAG---AGAGRRGLLLCRVDSDPPARLQLLHKDRVVA 644
+ A L VL P + ++ AG G L C+V P ++ +KD +
Sbjct: 5694 NMATLMVLEP--------AVIVEKAGPMTVTVGETCTLECKVAGTPELSVE-WYKDGKLL 5744
Query: 645 TSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATF 704
TS S + K + + + I + ++ G Y + N +G +S +A
Sbjct: 5745 TS-------------SQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVV 5791
Query: 705 NGQATVLAIAPSHTLQ---EGTEANLTCNVSREAAG-SPANFSWFRNGVLWAQGP----- 755
+ + A+ PS T + G +C + + AG SP + +WF G
Sbjct: 5792 D--VSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTT 5849
Query: 756 ----LETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGH 811
+ T+ L + +D Y C AG+ +L+V PP K L++ G
Sbjct: 5850 FSDNVCTLQLNSLDSSDMGNYTCVAANVAGSD-ECRAVLTVQEPPSFVKEPEPLEVLPGK 5908
Query: 812 MALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDS 871
F + P + F G L R E +LE+ + + S
Sbjct: 5909 NVTFTSVIRGTPPFKVNWFRGARELVKG--------DRCNIYFEDTVAELELFNIDISQS 5960
Query: 872 GSYRCEATNVLG--SSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYR 929
G Y C +N G S T LF + A+++ ++ G++++L +P S
Sbjct: 5961 GEYTCVVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLP--ISVT 6018
Query: 930 WYRDGQPLQES---------TSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHV 980
W +DG + S + L T AG Y C+ + A +L
Sbjct: 6019 WKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLE- 6077
Query: 981 SYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPR 1040
P VT ++ G L C+V P + GD + T P
Sbjct: 6078 --PPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPT-----------PE 6124
Query: 1041 LHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVRE- 1099
N L + + D G Y C+A N++G AS+ F Q + P + R+
Sbjct: 6125 YRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQL---PPSFARQL 6181
Query: 1100 -------GQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIP---LPNVT--------V 1141
G V LTC + + P Q+ WY+DG D ++ + NV +
Sbjct: 6182 KDIEQTVGLPVTLTCRLNGSAPIQV--CWYRDGVLLRDDENLQTSFVDNVATLKILQTDL 6239
Query: 1142 RDATSYRCGVGPP-----------GRAPRLS-----RPITLDVLYAPRNLRLTYLLESHG 1185
+ Y C P R P+ S +P+++DV+
Sbjct: 6240 SHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVI---------------A 6284
Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLL---ASSTAASVPNTLRLELRGPQPRDEGFYSCS 1242
G+ A C V P ++ S + + + T V NT L + D G Y+C
Sbjct: 6285 GESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQ 6344
Query: 1243 ARSPLGQANTSLELRL-EGVRVILAPEAA--VPEGAPITVTCADPAAHAPTL-YTWYHNG 1298
A + +G+ S +L + E + + EA+ +G I + C + +P + +W+ N
Sbjct: 6345 ATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLEC--KISGSPEIKVSWFRND 6402
Query: 1299 RWLQEGPAASLSFL---------VATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDA 1349
L E ++SF+ A+ +G Y C+A + G +S AL V P
Sbjct: 6403 SELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGD-ASCSTALTVKAPPVFT 6461
Query: 1350 VLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNAL 1409
S + S ++QC + PP E+ D K + S + H + + L
Sbjct: 6462 QKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSK---KFKITSKHFDTSLHIL 6518
Query: 1410 RLQVQDVPAGDDTYVCTAQNLLGS 1433
L+ DV Y C A N +GS
Sbjct: 6519 NLEASDV----GEYHCKATNEVGS 6538
Score = 164 bits (416), Expect = 5e-40
Identities = 323/1488 (21%), Positives = 536/1488 (36%), Gaps = 223/1488 (14%)
Query: 258 VTLTCQVNSSYPAVSSIKWLKDGVRL----------QTKTGVLHLPQAAWSDAGVYTCQA 307
+TL C V + P + +KWLKDG ++ + + D+G YT +
Sbjct: 5158 MTLECVVAGT-PELK-VKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKV 5215
Query: 308 ENGVGSLVSPPISLHIFMAEVQVSPAGPILE-----NQTVTLVCNTPNEAPSDLRYSWYK 362
EN GS S L + + S + + ++ + C P + W+K
Sbjct: 5216 ENDFGSS-SCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLP--ISAQWFK 5272
Query: 363 N---------HVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413
+ + L+ S +L ++ DT Y C+V NV G + + + V PP
Sbjct: 5273 DGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGI-LTVKEPPS 5331
Query: 414 TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNS 473
V QA + + + + + SG F G G S
Sbjct: 5332 FLVKPG--RQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKC----FIGLEGSTS 5385
Query: 474 LRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISP--AAEVVE-GQAVTLS 530
L + ++ + +G+Y C TN +G+ + T + A+++V+ G + L
Sbjct: 5386 F-LNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLE 5444
Query: 531 CRSGLSPTPDARFSWYLNGALLHEGPGSS------------LLLPAASSTDAGSYHCRAR 578
C+ ++ +P+ R W+ N HE P S + + S+ D+G + C A+
Sbjct: 5445 CK--IAGSPEIRVVWFRNE---HELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQ 5499
Query: 579 DGHSASGPSSPAVLTVLYPPRQPTFTTRLD-LDAAGAGAGRRGLLLCRVDSDPPARLQLL 637
+ ++ S+ + V PP +F ++ L A L C + PP + +
Sbjct: 5500 NPAGSTSCSTKVI--VKEPPVFSSFPPIVETLKNAEVS------LECELSGTPPFEV-VW 5550
Query: 638 HKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGN 697
+KD+ S S + K+ + I N + G Y C+A N +G+
Sbjct: 5551 YKDKRQLRS-------------SKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGS 5597
Query: 698 ASTSATFNGQATVLAIAP--SHTLQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGP 755
+ T + ++ S T+ G A L ++ P W + +
Sbjct: 5598 DTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIE---GAQPIFVQWLKEKEEVIRES 5654
Query: 756 -------LETVTLLPVARTD---AALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALL 805
+E V L A+ + A Y C+I + G + + L+ VL P + + +
Sbjct: 5655 ENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLM-VLEPAVIVEKAGPM 5713
Query: 806 DMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRE 865
+ G C V P + + LL +S + + + + L +
Sbjct: 5714 TVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISS--------LRILS 5765
Query: 866 LGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE-----GQAVVLSCQVHT 920
+ D+G+Y + N +G S+ + V V S + L+ G + +L C+V
Sbjct: 5766 VERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAG 5825
Query: 921 GVPEGTSYRWYRD------GQPLQESTS---ATLRFAAITLTQAGAYHCQAQAPGSATTS 971
P S W+ + G Q + S TL+ ++ + G Y C A +
Sbjct: 5826 SSP--ISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDEC 5883
Query: 972 LAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGV 1031
A L V P V ++ PG+ + PP ++ G R +
Sbjct: 5884 RAV---LTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVK----- 5935
Query: 1032 GGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQ--AVNV 1089
R ++ LE+ + G Y C SN GQAS + + A +
Sbjct: 5936 ------GDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFL 5989
Query: 1090 QVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS-----------IPLPN 1138
+ +V G+ + L T P ++ TW +DG + + + N
Sbjct: 5990 KRLSDHSVEPGKSIILESTYTGTLP--ISVTWKKDGFNITTSEKCNIVTTEKTCILEILN 6047
Query: 1139 VTVRDATSYRCGV-GPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDS 1197
T RDA Y C + GR + TL+ Y L LE+ G + C V
Sbjct: 6048 STKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEP---LEAAVGDSVSLQCQVAG 6104
Query: 1198 RPPAQLALSHAGRLLASSTAASV---PNTLRLELRGPQPRDEGFYSCSARSPLGQANTSL 1254
P ++ L + N L D G Y+C A + +G A++
Sbjct: 6105 TPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKT 6164
Query: 1255 ELRLEG-------VRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGP-- 1305
R++ R + E V G P+T+TC + AP WY +G L++
Sbjct: 6165 VFRIQERQLPPSFARQLKDIEQTV--GLPVTLTCRLNGS-APIQVCWYRDGVLLRDDENL 6221
Query: 1306 -------AASLSFLVATRAHAGAYSCQAQDAQGTRSS--RPAALQVLYAPQDAVLSSFRD 1356
A+L L +H+G YSC A + GT SS R A + +P + D
Sbjct: 6222 QTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSID 6281
Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416
A A +C V P + S D K + G + N L++ V
Sbjct: 6282 VIAGESADFECHVTGAQPMRITWSKDNKEIRPG--------GNYTITCVGNTPHLRILKV 6333
Query: 1417 PAGDD-TYVCTAQNLLGSISTIGRLQV-EGARVVA--EPGLDVPEGAALNLSCRLLGGPG 1472
GD Y C A N +G +L V E + V E +G ++ L C++ G P
Sbjct: 6334 GKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSP- 6392
Query: 1473 PVGNSTFAWFWNDRRLHAE---------PVPTLAFTHVARAQAGMYHCLAELPTGAAASA 1523
+WF ND LH V L + +G Y C A G A S
Sbjct: 6393 ---EIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDA-SC 6448
Query: 1524 PVMLRVLYPPKTPTMMVFVE---PEGGLRG---ILDCRVDSEPLASLTLHLGSRLVASSQ 1577
L V PP VF + P G L+G IL C + P + + V +S+
Sbjct: 6449 STALTVKAPP------VFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSK 6502
Query: 1578 PQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTS 1625
++ H S + L L SD GEY C A+N +GS + S
Sbjct: 6503 KFKITSK---HFDTSLHILN-----LEASDVGEYHCKATNEVGSDTCS 6542
Score = 161 bits (407), Expect = 6e-39
Identities = 347/1631 (21%), Positives = 583/1631 (35%), Gaps = 258/1631 (15%)
Query: 135 VTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPT 194
V E P PVE+++ ++V+ C V + W + R + +S+K+ T
Sbjct: 4951 VKEPPTFIRELKPVEVVKYSDVELECE---VTGTPPFEVTWLKNN--REIR-SSKKYTLT 5004
Query: 195 GVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILP 254
+ LH+ +C +S + +K P +K + + + +L
Sbjct: 5005 DRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTT--TVLK 5062
Query: 255 GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYT 304
T V S P SI WLKD L V L + +G YT
Sbjct: 5063 SS-ATFQSTVAGSPPI--SITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYT 5119
Query: 305 CQAENGVGS-------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVC---NTPNEAPS 354
CQA+N G LV P + V+ + + + E +TL C TP
Sbjct: 5120 CQAKNESGVERCYAFLLVQEPAQI------VEKAKSVDVTEKDPMTLECVVAGTP----- 5168
Query: 355 DLRYSWYKNHVLLEDAHSHTL---------RLHLATRADTGFYFCEVQNVHGSERSGPVS 405
+L+ W K+ + + ++ R+ + D+G Y +V+N GS
Sbjct: 5169 ELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYL 5228
Query: 406 VVVNH---PPLTPVLTAFLETQAGLVGILHCSVV-SEPLATLVLSHGGHILASTSGDSDH 461
V++ P T LT ++ G + C V S P++ G I S
Sbjct: 5229 RVLDQNIPPSFTKKLTK-MDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSA------ 5281
Query: 462 SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGN-ATSTLDFHANAARLLISPAAE 520
++ S+ LE+ +LE D+ Y C +N G+ A S + L+ P +
Sbjct: 5282 --KYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQ 5339
Query: 521 VVEGQAV---TLSCRSGLSPTPDARFSWYLNGALLHEGPG---------SSLLLPAASST 568
QA+ T+ ++ L TP + W+ + L GP S L L + ++
Sbjct: 5340 ----QAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDAS 5395
Query: 569 DAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDS 628
G Y C H + S + T+L P F +L+ AG L C++
Sbjct: 5396 KTGQYTC-----HVTNDVGSDSCTTMLLVTEPPKFVKKLEASKI-VKAGDSSRLECKIAG 5449
Query: 629 DPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYL 688
P R+ + LP+ S + ++T ++ ++++N E+ G ++
Sbjct: 5450 SPEIRVVWFRNEH----ELPA----------SDKYRMTFIDSVAVIQMNNLSTEDSGDFI 5495
Query: 689 CEASNALGNAS--TSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFR 746
CEA N G+ S T + P + E +L C +S P W++
Sbjct: 5496 CEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELS---GTPPFEVVWYK 5552
Query: 747 NG---------VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPD 797
+ + ++ ++ +L V +D Y C+ E G+ T V L P
Sbjct: 5553 DKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSD--TCVCTVKLKEPP 5610
Query: 798 R--PKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAE 855
R KL++L + L ++P+ + L E ++ S ++
Sbjct: 5611 RFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITF--------V 5662
Query: 856 ANSLKLEVRELGLGDSGSYRCEATNVLGS-SNTSLFFQVRGAWVQVSPSP-ELQEGQAVV 913
N L+ + ++G Y C+ N G N + + A + P + G+
Sbjct: 5663 ENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCT 5722
Query: 914 LSCQVHTGVPEGTSYRWYRDGQPLQESTS---------ATLRFAAITLTQAGAYHCQAQA 964
L C+V G PE S WY+DG+ L S ++LR ++ AG Y Q Q
Sbjct: 5723 LECKV-AGTPE-LSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQN 5780
Query: 965 PGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLG---LLLCRVDSDPPAQLRLLHGD 1021
+S A + + P T L +TG G LG +L C+V P + H
Sbjct: 5781 -NVGKSSCTAVVDVSDRAVPPSFT-RRLKNTG-GVLGASCILECKVAGSSPISVAWFHEK 5837
Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081
+ S + + N L+++ D G Y C A+N G A
Sbjct: 5838 TKIVS-----------GAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAV 5886
Query: 1082 FDAQAVNVQVWPGATVRE--------GQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH- 1132
Q P + V+E G+ V T ++ T P ++ W++ ++ +
Sbjct: 5887 LTVQE------PPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVN--WFRGARELVKGDR 5938
Query: 1133 ----------SIPLPNVTVRDATSYRCGVGP-PGRAPRLSRPITLDVLYAPRNLRLTYLL 1181
+ L N+ + + Y C V G+A +R L+ L
Sbjct: 5939 CNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTR------LFVKEPAAFLKRL 5992
Query: 1182 ESHG---GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLR---LELRGPQPRD 1235
H G+ ++ T P + G + +S ++ T + LE+ RD
Sbjct: 5993 SDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRD 6052
Query: 1236 EGFYSCSARSPLGQ-ANTSLELRLEGVRVI--LAP-EAAVPEGAPITVTCADPAAHAPTL 1291
G YSC + G+ +L LE + L P EAAV G +++ C T+
Sbjct: 6053 AGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAV--GDSVSLQCQVAGTPEITV 6110
Query: 1292 YTWYHNGRWLQEGP---------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPA-ALQ 1341
+WY L+ P A+L F +G Y+C+A+++ GT SS+ +Q
Sbjct: 6111 -SWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQ 6169
Query: 1342 VLYAPQDAVLSSFRDSRARSMAV-IQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTG 1400
P + + V + C ++ P ++ DG +L + T
Sbjct: 6170 ERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQ-----TS 6224
Query: 1401 HVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARV-----VAEPGLDV 1455
V LQ +G Y C+A N LG+ S+ RL + + +DV
Sbjct: 6225 FVDNVATLKILQTDLSHSGQ--YSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDV 6282
Query: 1456 PEGAALNLSCRLLGGPG-------------PVGNSTFAWFWNDRRLHAEPVPTLAFTHVA 1502
G + + C + G P GN T N P L V
Sbjct: 6283 IAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGN--------TPHLRILKVG 6334
Query: 1503 RAQAGMYHCLAELPTGAAASAPVMLRVLYPPK-TPTMMVFVEPEGGLRGILDCRVDSEPL 1561
+ +G Y C A G + L V PPK + + G L+C++ P
Sbjct: 6335 KGDSGQYTCQATNDVGKDMCS-AQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPE 6393
Query: 1562 ASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621
++ + S + +L I D G+YIC A N +G
Sbjct: 6394 IKVSWFRNDSELHESWKYNMSFINSVALLT--------INEASAEDSGDYICEAHNGVGD 6445
Query: 1622 ASTSTYFGVRA 1632
AS ST V+A
Sbjct: 6446 ASCSTALTVKA 6456
Score = 158 bits (400), Expect = 4e-38
Identities = 348/1716 (20%), Positives = 599/1716 (34%), Gaps = 260/1716 (15%)
Query: 53 DGITAIWYYDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGS 112
D + A WY D +E F+ + E R+ + + + + D+G
Sbjct: 3173 DDVDAHWYKDG---------------IEINFQVQERHKYVVERRIHRMFISETRQSDAGE 3217
Query: 113 YNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVR 172
Y F ++ NR S V E P+V PV + G F C+ + + Q +
Sbjct: 3218 YTF---VAGRNRSSVT--LYVNAPEPPQVLQELQPVTVQSGKPARF-CAV--ISGRPQPK 3269
Query: 173 LQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQ----LSVANHRAQS 228
+ W ++ S F + G TL + ++ + + C+ VA A
Sbjct: 3270 ISWYKEEQLLSTGFKCKFLHD---GQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASL 3326
Query: 229 EIHLQVKYAPKGVKILLSPSGRNIL------PGELVTLTCQVNSSYPAVSSIKWLKDGVR 282
+ + +P + P+ L G+ C+V+ + VS W +
Sbjct: 3327 SVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVS---WYSKDKK 3383
Query: 283 LQTK----------TGVLHLPQAAWSDAGVYTCQAENGVG--------SLVSPPISLH-I 323
++ T L + +A D G YT A N VG SL +P LH
Sbjct: 3384 IKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHER 3443
Query: 324 FMAEVQVS-PAGPILENQTVTL----------VCNTPNEAPSDLRYSWYKNHVLLEDAHS 372
E+++ A P+++ + L C ++ ++R+ W+K + ++
Sbjct: 3444 IEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEI--QSAPNVRFQWFKAGREIYESDK 3501
Query: 373 HTLRLH--------LATR-ADTGFYFCEVQNVHGS-ERSGPVSVVVNHPPLTPVLTAFLE 422
++R L T+ D G Y C+ N +GS + ++V +PP L
Sbjct: 3502 CSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLT 3561
Query: 423 TQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLE 482
T G C+V P+ + G L+ SP + + N LE+ +L
Sbjct: 3562 TFVGKAAKFICTVTGTPVIETIWQKDGAALSP-------SPNWRISDAENKHILELSNLT 3614
Query: 483 ETDSGEYKCSATNSLG--------------NATSTLDFHANAARLLISPAAEVVEGQAVT 528
D G Y C A+N G + L+ +A + +V E + VT
Sbjct: 3615 IQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINKKVHLECQVDEDRKVT 3674
Query: 529 LSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSS 588
++ P + + + E ++L +P A D+G+Y C A + A S
Sbjct: 3675 VTWSKDGQKLPPGK-----DYKICFEDKIATLEIPLAKLKDSGTYVCTA--SNEAGSSSC 3727
Query: 589 PAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLP 648
A +TV P P+F ++D G L C++ P ++ ++ ++ S
Sbjct: 3728 SATVTVREP---PSFVKKVDPSYLML-PGESARLHCKLKGSPVIQVTWFKNNKELSES-- 3781
Query: 649 SGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG--NASTSATFNG 706
+ RM + +L +I + +E+ G Y CEA N +G + ST
Sbjct: 3782 ----------NTVRMYFVNSEAIL--DITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKE 3829
Query: 707 QATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLE 757
+ + + GT A L C VS P SWF++ L++Q L
Sbjct: 3830 PPSFIKTLEPADIVRGTNALLQCEVS---GTGPFEISWFKDKKQIRSSKKYRLFSQKSLV 3886
Query: 758 TVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFIC 817
+ + D Y C + E G L P K+ L+ +G + L
Sbjct: 3887 CLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAA 3946
Query: 818 TVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCE 877
S P++ + G+ + + G+ + L + ++ + G Y C
Sbjct: 3947 VRGSEPIS-VTWMKGQEV--------IREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCL 3997
Query: 878 ATNVLGSSNT--SLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQ 935
A N GS + L + ++ + ++ G L V G PE +WY+DG+
Sbjct: 3998 AENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTV-AGTPE-LKPKWYKDGR 4055
Query: 936 PLQESTS---------ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRH 986
PL S A L+F + L +G Y + +++ L AP
Sbjct: 4056 PLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFF 4115
Query: 987 VTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVA 1046
+D+ L C++ P ++ + +A +S R +A
Sbjct: 4116 TKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIA-----------ASDRYRIAFV 4164
Query: 1047 PNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNL- 1105
T LEI + D G + C A+N++G +S A+ VQ P + G L
Sbjct: 4165 EGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSG-----ALIVQEPPSFVTKPGSKDVLP 4219
Query: 1106 ---TCLVWTTH-PAQLTYTWYQDGQQRLDA-----------HSIPLPNVTVRDATSYRCG 1150
CL T LT W++ ++ + S+ L V D+ +Y C
Sbjct: 4220 GSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCK 4279
Query: 1151 VGPPGRAPRLSRPITL-DVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAG 1209
V S + + + L + LL+ G + C V PP ++
Sbjct: 4280 VSNVAGGVECSANLFVKEPATFVEKLEPSQLLKK--GDATQLACKVTGTPPIKITWFAND 4337
Query: 1210 RLLASST---AASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILA 1266
R + S+ + V +T L L D G Y C A++ G + S + ++
Sbjct: 4338 REIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCS------SIVIVKE 4391
Query: 1267 PEAAVPEGAPITV-------TCADPAAHAPTLYTWYHNGRWLQEG---------PAASLS 1310
E PI V A+ A P TW+ + L+ G SL
Sbjct: 4392 SPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQ 4451
Query: 1311 FLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR-SMAVIQCTV 1369
L A AG Y C+ + G SS +A L P + S R A Q T+
Sbjct: 4452 ILKFVAADAGEYQCRVTNEVG--SSICSARVTLREPPSFIKKIESTSSLRGGTAAFQATL 4509
Query: 1370 DSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPA-GDDTYVCTAQ 1428
P + D + + + N L + + D YVC A+
Sbjct: 4510 KGSLPITVTWLKDSDEITEDDNI--------RMTFENNVASLYLSGIEVKHDGKYVCQAK 4561
Query: 1429 NLLGSISTIGRLQVEGARVVAEP--GLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDR 1486
N G L V+ + E +DV +G L + G T WF + +
Sbjct: 4562 NDAGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSG----TKEITAKWFKDGQ 4617
Query: 1487 RLH---------AEPVPTLAFTHVARAQAGMYHCLAELPTG-AAASAPV-MLRVLYPPKT 1535
L + V L + +G Y + G ++ A + +L ++ PP
Sbjct: 4618 ELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSF 4677
Query: 1536 PTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNA 1595
+ ++ G L+C V S+ + +++S+ N
Sbjct: 4678 TKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASE--------KYKFSFHDNT 4729
Query: 1596 LRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
++I L +D G Y CSA+N G S + V+
Sbjct: 4730 AFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVK 4765
Score = 157 bits (396), Expect = 1e-37
Identities = 328/1640 (20%), Positives = 590/1640 (35%), Gaps = 234/1640 (14%)
Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159
L L D+ EDSG Y ++ SD ++V V E P P+E+L+ +V
Sbjct: 4357 LRLTDVGIEDSGEYMCE---AQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLL 4413
Query: 160 CSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQL 219
V + W + ++ + +K++ HL +L + +C++
Sbjct: 4414 AE---VAGTPPFEITWFKDN---TILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRV 4467
Query: 220 SVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKD 279
+ + + ++ P +K + S S L G + S P ++ WLKD
Sbjct: 4468 TNEVGSSICSARVTLREPPSFIKKIESTSS---LRGGTAAFQATLKGSLPI--TVTWLKD 4522
Query: 280 G--------VRLQTKTGV--LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQ 329
+R+ + V L+L G Y CQA+N G + A +
Sbjct: 4523 SDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAG--------IQRCSALLS 4574
Query: 330 VSPAGPILENQTVTLVCNTPNEAPSDLRYS--------WYKN----------HVLLEDAH 371
V I E + V++ + A +++S W+K+ + + D
Sbjct: 4575 VKEPATITE-EAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTDTV 4633
Query: 372 SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGI- 430
S L++ + D+G Y EVQN G S + V + P T L+ + G
Sbjct: 4634 S-ILKIISTEKKDSGEYTFEVQNDVGRS-SCKARINVLDLIIPPSFTKKLKKMDSIKGSF 4691
Query: 431 --LHCSVV-SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
L C V S P++ I AS ++ + N+ LEI LE TDSG
Sbjct: 4692 IDLECIVAGSHPISIQWFKDDQEISASE--------KYKFSFHDNTAFLEISQLEGTDSG 4743
Query: 488 EYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYL 547
Y CSATN G+ + + + ++ + T W+
Sbjct: 4744 TYTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFK 4803
Query: 548 NGALLHEG---------PGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
+ LH G +SL L AA +TD+G+Y C+ + +S A L V PP
Sbjct: 4804 DNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQL--SNDVGTATSKATLFVKEPP 4861
Query: 599 R-----QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGC 653
+ P R G+ C++ P R+ + D T++ G
Sbjct: 4862 QFIKKPSPVLVLR---------NGQSTTFECQITGTPKIRVS-WYLDGNEITAIQKHG-- 4909
Query: 654 STCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAI 713
++ L +I +E G Y+CEA N G AS S + I
Sbjct: 4910 -----------ISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFI 4958
Query: 714 APSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVT---------LL 762
++ + ++ L C V+ P +W +N T+T +
Sbjct: 4959 RELKPVEVVKYSDVELECEVT---GTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHIT 5015
Query: 763 PVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSR 822
+D Y C I++ G S +++ PP K A F TV
Sbjct: 5016 KCDPSDTGEYQC-IVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGS 5074
Query: 823 PLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVL 882
P + + +L + L++R + G SG Y C+A N
Sbjct: 5075 PPISITWLKDDQIL--------DEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNES 5126
Query: 883 GSSNTSLFFQVR--GAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQ-- 938
G F V+ V+ + S ++ E + L C V G PE +W +DG+ +
Sbjct: 5127 GVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVV-AGTPE-LKVKWLKDGKQIVPS 5184
Query: 939 -------ESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTT 991
E+ A+ R ++ +G Y + + +++ A L + P T
Sbjct: 5185 RYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLT 5244
Query: 992 LMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLR 1051
MD G + C+V P + + ++ +S + + ++
Sbjct: 5245 KMDKVLGSSIHMECKVSGSLPISAQWFKDGKEIS-----------TSAKYRLVCHERSVS 5293
Query: 1052 LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQ-------LVN 1104
LE++ LED Y C+ SN G + S + V+ P V+ G+ V
Sbjct: 5294 LEVNNLELEDTANYTCKVSNVAGDDACSG-----ILTVKEPPSFLVKPGRQQAIPDSTVE 5348
Query: 1105 LTCLVWTTHPAQLTYTWYQDGQQRLDAHS-----------IPLPNVTVRDATSYRCGV-G 1152
++ T P ++ W++D + + + L +V Y C V
Sbjct: 5349 FKAILKGTPPFKI--KWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTN 5406
Query: 1153 PPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLL 1212
G + + + + L + ++++ G + + C + P ++ L
Sbjct: 5407 DVGSDSCTTMLLVTEPPKFVKKLEASKIVKA--GDSSRLECKIAGSPEIRVVWFRNEHEL 5464
Query: 1213 ASS---TAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVI--LAP 1267
+S + + +++ D G + C A++P G + S ++ ++ V P
Sbjct: 5465 PASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPP 5524
Query: 1268 EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPA---------ASLSFLVATRAH 1318
+ A +++ C + + P WY + R L+ S+ L +
Sbjct: 5525 IVETLKNAEVSLEC-ELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSD 5583
Query: 1319 AGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELA 1378
G Y C+AQ+ G+ + +++ P+ + A A +Q +++ P +
Sbjct: 5584 IGEYHCKAQNEVGS-DTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQ 5642
Query: 1379 -LSHDGKVLATSSGVHSLASGTGHVQVARNALRLQ-VQDVPAGDDTYVCTAQNLLGSIST 1436
L +V+ S + + N LQ + PA Y+C +N G
Sbjct: 5643 WLKEKEEVIRESENI--------RITFVENVATLQFAKAEPANAGKYICQIKNDGGMREN 5694
Query: 1437 IGRLQV-EGARVVAEPG-LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA---- 1490
+ L V E A +V + G + V G L C++ G P + W+ + + L +
Sbjct: 5695 MATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTP----ELSVEWYKDGKLLTSSQKH 5750
Query: 1491 -----EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPE 1545
+ +L V R AG Y + G +S ++ V P+ ++
Sbjct: 5751 KFSFYNKISSLRILSVERQDAGTYTFQVQNNVG-KSSCTAVVDVSDRAVPPSFTRRLKNT 5809
Query: 1546 GGLRG---ILDCRV-DSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIE 1601
GG+ G IL+C+V S P++ H +++V+ ++ Q S N + +
Sbjct: 5810 GGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQ---------TTFSDNVCTLQLN 5860
Query: 1602 ALRPSDQGEYICSASNVLGS 1621
+L SD G Y C A+NV GS
Sbjct: 5861 SLDSSDMGNYTCVAANVAGS 5880
Score = 150 bits (380), Expect = 8e-36
Identities = 314/1497 (20%), Positives = 525/1497 (35%), Gaps = 247/1497 (16%)
Query: 253 LPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTK----------TGVLHLPQAAWSDAGV 302
+ G + L C V S+P SI+W KD + T L + Q +D+G
Sbjct: 4687 IKGSFIDLECIVAGSHPI--SIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGT 4744
Query: 303 YTCQAENGVG--------SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPS 354
YTC A N G ++ PP F+ + Q P Q LV T AP
Sbjct: 4745 YTCSATNKAGHNQCSGHLTVKEPPY----FVEKPQSQDVNPNTRVQLKALVGGT---APM 4797
Query: 355 DLRYSWYKNHVLL---------EDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVS 405
++ W+K++ L +D S +L L A D+G Y C++ N G+ S
Sbjct: 4798 TIK--WFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATL 4855
Query: 406 VVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRF 465
V P + L + G C + P + G+ + +
Sbjct: 4856 FVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKH------- 4908
Query: 466 SGTSGPNSLR-LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA--AEVV 522
G S + L +I +SG Y C A N G A+ +++ I EVV
Sbjct: 4909 -GISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRELKPVEVV 4967
Query: 523 EGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLL---------LPAASSTDAGSY 573
+ V L C ++ TP +W N + +L + +D G Y
Sbjct: 4968 KYSDVELECE--VTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEY 5025
Query: 574 HCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPAR 633
C + G S + L P P+F +++ + V PP
Sbjct: 5026 QCIVSN---EGGSCSCSTRVALKEP--PSFIKKIENTTTVLKSS--ATFQSTVAGSPPIS 5078
Query: 634 LQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASN 693
+ L D+++ + ++ ++ ++I + G Y C+A N
Sbjct: 5079 ITWLKDDQILDED--------------DNVYISFVDSVATLQIRSVDNGHSGRYTCQAKN 5124
Query: 694 ALGNASTSATFNGQ--ATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFRNGV- 749
G A Q A ++ A S + E L C V AG+P W ++G
Sbjct: 5125 ESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVV----AGTPELKVKWLKDGKQ 5180
Query: 750 --------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVL---YPPDR 798
+ + + + + V + D+ Y ++ + G+ S L VL PP
Sbjct: 5181 IVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSS-SCDAYLRVLDQNIPPSF 5239
Query: 799 PKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANS 858
K +D G C V S L + A + + G ++ + +++ S
Sbjct: 5240 TKKLTKMDKVLGSSIHMECKV-SGSLPISAQWFKD-------GKEISTSAKYRLVCHERS 5291
Query: 859 LKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEG--QAVVLSC 916
+ LEV L L D+ +Y C+ +NV G S V+ PS ++ G QA+ S
Sbjct: 5292 VSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVK-----EPPSFLVKPGRQQAIPDST 5346
Query: 917 QVHTGVPEGT---SYRWYRDGQPL---------QESTSATLRFAAITLTQAGAYHCQAQ- 963
+ +GT +W++D L E +++ L ++ ++ G Y C
Sbjct: 5347 VEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTN 5406
Query: 964 --APGSATTSLAAPISLHVSYAPRHV-TLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020
S TT L V+ P+ V L G L C++ P ++
Sbjct: 5407 DVGSDSCTTMLL------VTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRN 5460
Query: 1021 DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASA 1080
+ + +S + + + ++++ ED G +ICEA N G S S
Sbjct: 5461 EHELP-----------ASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCST 5509
Query: 1081 DFDAQAVNV--QVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH------ 1132
+ V P + V+L C + T P ++ WY+D +Q +
Sbjct: 5510 KVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEV--VWYKDKRQLRSSKKYKIAS 5567
Query: 1133 -----SIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQ 1187
SI + NV D Y C + T+ + PR + L G+
Sbjct: 5568 KNFHTSIHILNVDTSDIGEYHCKA--QNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGE 5625
Query: 1188 LALVLCTVDSRPPAQLA-LSHAGRLLASS---TAASVPNTLRLELRGPQPRDEGFYSCSA 1243
A + +++ P + L ++ S V N L+ +P + G Y C
Sbjct: 5626 PAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQI 5685
Query: 1244 RSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCAD------PAAHAPTL-YTWYH 1296
++ G L ++L P V + P+TVT + A P L WY
Sbjct: 5686 KNDGGMRENMATL------MVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYK 5739
Query: 1297 NGRWLQE---------GPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQ 1347
+G+ L +SL L R AG Y+ Q Q+ G +SS A + V
Sbjct: 5740 DGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVG-KSSCTAVVDV---SD 5795
Query: 1348 DAVLSSFRDSRAR------SMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGH 1401
AV SF + +++C V P +A H+ + + + + S
Sbjct: 5796 RAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSD--- 5852
Query: 1402 VQVARNALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQV-EGARVVAEP-GLDVPEG 1458
N LQ+ + + D Y C A N+ GS L V E V EP L+V G
Sbjct: 5853 -----NVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPG 5907
Query: 1459 AALNLSCRLLGGPGPVGNSTFAWFWNDRRL---------HAEPVPTLAFTHVARAQAGMY 1509
+ + + G P N WF R L + V L ++ +Q+G Y
Sbjct: 5908 KNVTFTSVIRGTPPFKVN----WFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEY 5963
Query: 1510 HCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTL--- 1566
C+ G A+ T + EP L+ + D V EP S+ L
Sbjct: 5964 TCVVSNNAGQASCT-------------TRLFVKEPAAFLKRLSDHSV--EPGKSIILEST 6008
Query: 1567 HLGSRLVASSQPQ---GAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620
+ G+ ++ + + +++ + ++I D G+Y C N G
Sbjct: 6009 YTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAG 6065
Score = 140 bits (353), Expect = 1e-32
Identities = 293/1321 (22%), Positives = 474/1321 (35%), Gaps = 211/1321 (15%)
Query: 135 VTEEPRVPTIASPVELLEGTEVDFNCSTPYVCL---QEQVRLQWQGQDPARSVTFNSQKF 191
V E PR P +++ E T Y C ++++ W + S KF
Sbjct: 7301 VQEPPRFIKKLEPSRIVKQDEF-----TRYECKIGGSPEIKVLWYKDETEIQ---ESSKF 7352
Query: 192 EPTGVGHLETLHMA-MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGR 250
+ V + L M +S +D G C+ A A S L+VK P K P
Sbjct: 7353 RMSFVDSVAVLEMHNLSVEDSGDYT-CEAHNAAGSASSSTSLKVKEPPIFRK---KPHPI 7408
Query: 251 NILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDA 300
L G V L C++ + P + W KD L++ +H+ +D
Sbjct: 7409 ETLKGADVHLECELQGTPPF--HVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADI 7466
Query: 301 GVYTCQAENGVGS--------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEA 352
G Y C+A N VGS L +PP + ++S ++ + + T E
Sbjct: 7467 GEYQCKATNDVGSDTCVGSIALKAPPRFVK------KLSDISTVVGKE---VQLQTTIEG 7517
Query: 353 PSDLRYSWYK----------NHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSG 402
+ W+K N + + TL+ A+ G Y C+++N G +
Sbjct: 7518 AEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECF 7577
Query: 403 PVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEP-LATLVLSHGGHILASTSGDSDH 461
++ V P ++ G L C+V P L+T G + TS +
Sbjct: 7578 -ATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKEL---TSDNKYK 7633
Query: 462 SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEV 521
F+ SG L+I ++ +DSG Y N +G + T + + S ++
Sbjct: 7634 ISFFNKVSG-----LKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKL 7688
Query: 522 VE-----GQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPG---------SSLLLPAASS 567
E G +V + C+ + +P SW+ G + G +L +
Sbjct: 7689 KETNGLSGSSVVMECK--VYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEE 7746
Query: 568 TDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLD-LDAAGAGAGRRGLLLCRV 626
+D+G Y C A + + S+P LTV PP +F + D +D G V
Sbjct: 7747 SDSGDYTCIATNMAGSDECSAP--LTVREPP---SFVQKPDPMDVL---TGTNVTFTSIV 7798
Query: 627 DSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGL 686
PP + ++ L G C+ V+ ++ +E+ + + G
Sbjct: 7799 KGTPPFSVSWFKG----SSELVPGDRCN----------VSLEDSVAELELFDVDTSQSGE 7844
Query: 687 YLCEASNALGNAS--TSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSW 744
Y C SN G AS T A + +++++G L + P + +W
Sbjct: 7845 YTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFT---GTPPISVTW 7901
Query: 745 FRNGVLWAQGPLETVT------LLPVART---DAALYACRILTEAGAQLSTPVLLSVLYP 795
+NG+ +T +L + + DA Y C I +G + +L +L P
Sbjct: 7902 KKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQIL-ILEP 7960
Query: 796 PDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAE 855
P K + + G A C + P ++ + G+ T L P F+
Sbjct: 7961 PYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGD----TKLRPTTTYKMHFRN--- 8013
Query: 856 ANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE-----GQ 910
N L ++ + DSG Y C+A N +G + S F V+ + S S +L++ G
Sbjct: 8014 -NVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGL 8072
Query: 911 AVVLSCQVHTGVPEGTSYRWYRDGQPLQES---------TSATLRFAAITLTQAGAYHCQ 961
VV C + P S WY+DG+PL++S +ATL + AG Y C
Sbjct: 8073 PVVFDCAISGSEPISVS--WYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCT 8130
Query: 962 AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGD 1021
A P + +S A I P +D G C V P ++
Sbjct: 8131 ATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDS 8190
Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081
R + S GG + ++ N+ L + D G Y C A N +G+ S +A
Sbjct: 8191 REIRS-----GG------KYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQ 8239
Query: 1082 FDAQAVNVQVWPGATVR--------EGQLVNLTCLVWTTHPAQLTYTWYQDGQ--QRLDA 1131
+ + + P T R EG L V + P +T WY++ Q
Sbjct: 8240 LNIKERLIP--PSFTKRLSETVEETEGNSFKLEGRVAGSQP--ITVAWYKNNIEIQPTSN 8295
Query: 1132 HSIPLPNVTV---------RDATSYRCGVGPPGRAPRLSRPITLDVLYAPR--NLRLTYL 1180
I N T+ DA Y C V + + I + P + LT +
Sbjct: 8296 CEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPV 8355
Query: 1181 LESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAAS---VPNTLRLELRGPQPRDEG 1237
S G + L C V P ++ AGR + S S T LELR D G
Sbjct: 8356 TVSEGEYVQLS-CHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSG 8414
Query: 1238 FYSCSARSPLGQANTSLELRLEGVRVILAP---EAAV---------PEGAPI----TVTC 1281
Y C A + G T ++ ++ + +AP +AAV P+ + T T
Sbjct: 8415 DYVCKASNVAGSDTTKSKVTIKD-KPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATF 8473
Query: 1282 ADPAAHAPTLYTWYHNGRWL-----------QEGPAASLSFLVATRAHAGAYSCQAQDAQ 1330
P + G+W Q+G A L T+ +G Y C A +
Sbjct: 8474 IAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEH 8533
Query: 1331 G 1331
G
Sbjct: 8534 G 8534
Score = 119 bits (297), Expect = 3e-26
Identities = 188/853 (22%), Positives = 310/853 (36%), Gaps = 121/853 (14%)
Query: 95 HRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTV-TEEPRVPTIASPVELLEG 153
++V L + ++ P DSG Y+F + + V + S V+ T P L G
Sbjct: 7638 NKVSGLKIINVAPSDSGVYSFEVQ-NPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSG 7696
Query: 154 TEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGR 213
+ V C V + + W + S + +K++ T + L + M +
Sbjct: 7697 SSVVMECK---VYGSPPISVSWFHEGNEIS---SGRKYQTTLTDNTCALTVNMLEESDSG 7750
Query: 214 ILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSS 273
C + + L V+ P V+ P ++L G VT T V + P S
Sbjct: 7751 DYTCIATNMAGSDECSAPLTVREPPSFVQ---KPDPMDVLTGTNVTFTSIVKGTPPF--S 7805
Query: 274 IKWLKDG----------VRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSL-------VS 316
+ W K V L+ L L S +G YTC N G +
Sbjct: 7806 VSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIK 7865
Query: 317 PPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH----- 371
P + + + P++ T T TP + +W KN + + +
Sbjct: 7866 APAKFVKRLNDYSIEKGKPLILEGTFT---GTP-----PISVTWKKNGINVTPSQRCNIT 7917
Query: 372 ----SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGL 427
S L + +T D G Y C ++N G + S +++ PP ++ G
Sbjct: 7918 TTEKSAILEIPSSTVEDAGQYNCYIENASGKD-SCSAQILILEPPYFVKQLEPVKVSVGD 7976
Query: 428 VGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
L C + P + G L T+ H N L ++ DSG
Sbjct: 7977 SASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRN-------NVATLVFNQVDINDSG 8029
Query: 488 EYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE-----GQAVTLSCRSGLSPTPDAR 542
EY C A NS+G +++ +L S + ++ + G V C +S +
Sbjct: 8030 EYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDC--AISGSEPIS 8087
Query: 543 FSWYLNGALLHEGPG--SSLLLPAAS----STD---AGSYHCRARDGHSASGPSSPAVLT 593
SWY +G L + P +S L A+ TD AG Y C A + ++ S+ +LT
Sbjct: 8088 VSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILT 8147
Query: 594 VLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGC 653
P P F RL A G C V P ++ R + SGG
Sbjct: 8148 EGKNP--PFFDIRLA--PVDAVVGESADFECHVTGTQPIKVSWAKDSREIR----SGG-- 8197
Query: 654 STCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAI 713
+ +++ N + + + G Y C A N +G S +A N + + I
Sbjct: 8198 --------KYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERL--I 8247
Query: 714 APSHTLQ-----EGTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLETV 759
PS T + E TE N R A P +W++N + + + +
Sbjct: 8248 PPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVL 8307
Query: 760 TLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLS----ALLDMGQGHMALF 815
+ DA LY C++ +AG+ L T + V+ P +P + + + +G
Sbjct: 8308 QVRKAGMNDAGLYTCKVSNDAGSALCTSSI--VIKEPKKPPVFDQHLTPVTVSEGEYVQL 8365
Query: 816 ICTVD-SRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSY 874
C V S P+ + L G ++ R + + LE+R++ DSG Y
Sbjct: 8366 SCHVQGSEPIRIQWL---------KAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDY 8416
Query: 875 RCEATNVLGSSNT 887
C+A+NV GS T
Sbjct: 8417 VCKASNVAGSDTT 8429
Score = 119 bits (297), Expect = 3e-26
Identities = 213/928 (22%), Positives = 345/928 (37%), Gaps = 162/928 (17%)
Query: 251 NILPGELVTLTCQVNSSYPAVSSIKWLKDG----------VRLQTKTGVLHLPQAAWSDA 300
N L G V + C+V S P S+ W +G L T L + SD+
Sbjct: 7692 NGLSGSSVVMECKVYGSPPI--SVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDS 7749
Query: 301 GVYTCQAENGVGS-LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYS 359
G YTC A N GS S P+++ + VQ +L VT P + S
Sbjct: 7750 GDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSV--S 7807
Query: 360 WYKN----------HVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVN 409
W+K +V LED+ + L L + +G Y C V N G + S + +
Sbjct: 7808 WFKGSSELVPGDRCNVSLEDSVAE-LELFDVDTSQSGEYTCIVSNEAG-KASCTTHLYIK 7865
Query: 410 HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTS 469
P + G IL + P ++ G + S R + T+
Sbjct: 7866 APAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTP-------SQRCNITT 7918
Query: 470 GPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA--------AEV 521
S LEI D+G+Y C N+ G + +A L++ P +V
Sbjct: 7919 TEKSAILEIPSSTVEDAGQYNCYIENASGKDS------CSAQILILEPPYFVKQLEPVKV 7972
Query: 522 VEGQAVTLSCRSGLSPTPDARFSWYLNGALLH---------EGPGSSLLLPAASSTDAGS 572
G + +L C+ L+ TP+ SWY L ++L+ D+G
Sbjct: 7973 SVGDSASLQCQ--LAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGE 8030
Query: 573 YHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRL-DLDAAGAGAGRRGLLLCRVDSDPP 631
Y C+A + S S+ LTV P+F+ +L D+ G + C + P
Sbjct: 8031 YICKAEN--SVGEVSASTFLTVQEQKLPPSFSRQLRDVQET---VGLPVVFDCAISGSEP 8085
Query: 632 ARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEA 691
+ + + S P ++ + N + I G Y C A
Sbjct: 8086 ISVSWYKDGKPLKDS--------------PNVQTSFLDNTATLNIFKTDRSLAGQYSCTA 8131
Query: 692 SNALGNASTSATF------NGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSW- 744
+N +G+AS+SA N + +AP + G A+ C+V+ P SW
Sbjct: 8132 TNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVV-GESADFECHVT---GTQPIKVSWA 8187
Query: 745 -----FRNGVLWAQGPLET---VTLLPVARTDAALYACRILTEAGAQLSTPVL--LSVLY 794
R+G + LE +T+L V + D+ Y C + E G T L L
Sbjct: 8188 KDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLI 8247
Query: 795 PPDRPK-LSALLDMGQGH-MALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQA 852
PP K LS ++ +G+ L S+P+ + + + TS +
Sbjct: 8248 PPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTS---------NCEI 8298
Query: 853 KAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRG-----AWVQVSPSPELQ 907
+ N+L L+VR+ G+ D+G Y C+ +N GS+ + ++ + Q +
Sbjct: 8299 TFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVS 8358
Query: 908 EGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAA---------ITLTQAGAY 958
EG+ V LSC V P +W + G+ ++ S + FA+ + +G Y
Sbjct: 8359 EGEYVQLSCHVQGSEP--IRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDY 8416
Query: 959 HCQAQ-APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRL 1017
C+A GS TT I + AP T +D GRL + P +R+
Sbjct: 8417 VCKASNVAGSDTTKSKVTIKDKPAVAP--ATKKAAVD---GRLFFV------SEPQSIRV 8465
Query: 1018 LHGDRLVASTLQGVGGPE--------------GSSPRLHVAVAPNTLRLEIHGAMLEDEG 1063
+ ++ A+ + VGG R+ + + +LEI D G
Sbjct: 8466 V--EKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSG 8523
Query: 1064 VYICEASNTLGQASASADFDAQAVNVQV 1091
+Y C A N G+ ++ VN+QV
Sbjct: 8524 LYRCVAFNEHGEIESN-------VNLQV 8544
Score = 116 bits (290), Expect = 2e-25
Identities = 333/1668 (19%), Positives = 588/1668 (35%), Gaps = 232/1668 (13%)
Query: 106 QPEDSGSYNFRFEISEVNRWS-DVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPY 164
+ +DSG Y F + ++V R S + ++ + P ++ ++G+ +D C
Sbjct: 4642 EKKDSGEYTFEVQ-NDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLEC---I 4697
Query: 165 VCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMA-MSWQDHGRILRCQLSVAN 223
V + +QW D S S+K++ + + L ++ + D G + A
Sbjct: 4698 VAGSHPISIQWFKDDQEISA---SEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAG 4754
Query: 224 HRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRL 283
H Q HL VK P V+ P +++ P V L V + P +IKW KD L
Sbjct: 4755 HN-QCSGHLTVKEPPYFVE---KPQSQDVNPNTRVQLKALVGGTAPM--TIKWFKDNKEL 4808
Query: 284 QTKTG----------VLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEV----- 328
+ L L A +D+G Y CQ N VG+ S +F+ E
Sbjct: 4809 HSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKAT---LFVKEPPQFIK 4865
Query: 329 QVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH---------TLRLHL 379
+ SP + Q+ T C +R SWY + + H T ++
Sbjct: 4866 KPSPVLVLRNGQSTTFECQITGTPK--IRVSWYLDGNEITAIQKHGISFIDGLATFQISG 4923
Query: 380 ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPP-----LTPV-LTAFLETQAGLVGILHC 433
A ++G Y CE +N G+ S + + V PP L PV + + + + L C
Sbjct: 4924 ARVENSGTYVCEARNDAGTA-SCSIELKVKEPPTFIRELKPVEVVKYSDVE------LEC 4976
Query: 434 SVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSA 493
V P + + S S +++ T + L I + +D+GEY+C
Sbjct: 4977 EVTGTPPFEVTWLKNNREIRS-------SKKYTLTDRVSVFNLHITKCDPSDTGEYQCIV 5029
Query: 494 TNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH 553
+N G+ + + I + + +S ++ +P +W + +L
Sbjct: 5030 SNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILD 5089
Query: 554 EGPG---------SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFT 604
E ++L + + + +G Y C+A++ A L V P +
Sbjct: 5090 EDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVE--RCYAFLLVQEPAQIVEKA 5147
Query: 605 TRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMK 664
+D+ L C V P +++ L + + S
Sbjct: 5148 KSVDVTEKDPMT-----LECVVAGTPELKVKWLKDGKQIVPSR--------------YFS 5188
Query: 665 VTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQE--- 721
++ N+ I + + ++ G Y + N G++S A + I PS T +
Sbjct: 5189 MSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYL--RVLDQNIPPSFTKKLTKM 5246
Query: 722 ----GTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLETVTLLPVARTD 768
G+ ++ C VS P + WF++G L ++ + + D
Sbjct: 5247 DKVLGSSIHMECKVS---GSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELED 5303
Query: 769 AALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLA 828
A Y C++ AG + +L +V PP S L+ G+ A+ TV+ + A+L
Sbjct: 5304 TANYTCKVSNVAGDDACSGIL-TVKEPP-----SFLVKPGR-QQAIPDSTVEFK--AILK 5354
Query: 829 LFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN-- 886
+ ++ S + E ++ L + + +G Y C TN +GS +
Sbjct: 5355 GTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCT 5414
Query: 887 TSLFFQVRGAWVQ-VSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTS--- 942
T L +V+ + S ++ G + L C++ G PE W+R+ L S
Sbjct: 5415 TMLLVTEPPKFVKKLEASKIVKAGDSSRLECKI-AGSPE-IRVVWFRNEHELPASDKYRM 5472
Query: 943 ------ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTG 996
A ++ ++ +G + C+AQ P +T+ I V P + +++T
Sbjct: 5473 TFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVI---VKEPPVFSSFPPIVETL 5529
Query: 997 PGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHG 1056
L C + PP ++ R + S S + +A + I
Sbjct: 5530 KNAEVSLECELSGTPPFEVVWYKDKRQLRS-----------SKKYKIASKNFHTSIHILN 5578
Query: 1057 AMLEDEGVYICEASNTLGQASASADFDAQAVN--VQVWPGATVREGQLVNLTCLVWTTHP 1114
D G Y C+A N +G + + V TV G+ L + P
Sbjct: 5579 VDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQP 5638
Query: 1115 AQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRN 1174
+ W ++ ++ + S + V + + + P A + I D
Sbjct: 5639 --IFVQWLKEKEEVI-RESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENM 5695
Query: 1175 LRLTYL-----LESHG------GQLALVLCTVDSRPPAQLALSHAGRLLASSTAA--SVP 1221
L L +E G G+ + C V P + G+LL SS S
Sbjct: 5696 ATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFY 5755
Query: 1222 NTLR-LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE------- 1273
N + L + + +D G Y+ ++ +G+++ + V+ + AVP
Sbjct: 5756 NKISSLRILSVERQDAGTYTFQVQNNVGKSSCTA--------VVDVSDRAVPPSFTRRLK 5807
Query: 1274 ------GAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFL--VAT-------RAH 1318
GA + C A +P W+H + G +F V T +
Sbjct: 5808 NTGGVLGASCILECK-VAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSD 5866
Query: 1319 AGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELA 1378
G Y+C A + G+ R A L V P + + PP ++
Sbjct: 5867 MGNYTCVAANVAGSDECR-AVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVN 5925
Query: 1379 LSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIG 1438
+ L + T VA L L D+ + Y C N G S
Sbjct: 5926 WFRGARELVKGDRCNIYFEDT----VAE--LELFNIDISQSGE-YTCVVSNNAGQASCTT 5978
Query: 1439 RLQVEGARVVAEPGLD--VPEGAALNLSCRLLGGPGPVG--------NSTFAWFWNDRRL 1488
RL V+ + D V G ++ L G P+ N T + N +
Sbjct: 5979 RLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTL-PISVTWKKDGFNITTSEKCNI--V 6035
Query: 1489 HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGL 1548
E L + + AG Y C E G ++ L PP T + +E G
Sbjct: 6036 TTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCG-ALVSTLEPPYFVTELEPLEAAVGD 6094
Query: 1549 RGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQ 1608
L C+V P +++ + G + + P + N + + +D
Sbjct: 6095 SVSLQCQVAGTPEITVSWYKGDTKLRPT--------PEYRTYFTNNVATLVFNKVNINDS 6146
Query: 1609 GEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLLL 1656
GEY C A N +G+AS+ T F ++ F + L + VGL + L
Sbjct: 6147 GEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTL 6194
Score = 113 bits (283), Expect = 1e-24
Identities = 195/869 (22%), Positives = 321/869 (36%), Gaps = 134/869 (15%)
Query: 98 CNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVD 157
C L + L+ DSG Y I+ SD +TV E P P+++L GT V
Sbjct: 7737 CALTVNMLEESDSGDYTC---IATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVT 7793
Query: 158 FNCSTPYVCLQEQVRLQW-QGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILR 216
F T V + W +G + E + V LE + S
Sbjct: 7794 F---TSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDS-VAELELFDVDTSQSGE---YT 7846
Query: 217 CQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW 276
C +S +A HL +K K VK L + +I G+ + L + P S+ W
Sbjct: 7847 CIVSNEAGKASCTTHLYIKAPAKFVKRL---NDYSIEKGKPLILEGTFTGTPPI--SVTW 7901
Query: 277 LKDGVRLQT----------KTGVLHLPQAAWSDAGVYTCQAENGVGS--------LVSPP 318
K+G+ + K+ +L +P + DAG Y C EN G ++ PP
Sbjct: 7902 KKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPP 7961
Query: 319 ISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTL--R 376
+ Q+ P + + +L C ++ SWYK L ++ + R
Sbjct: 7962 YFVK------QLEPV-KVSVGDSASLQCQLAGTP--EIGVSWYKGDTKLRPTTTYKMHFR 8012
Query: 377 LHLATRA-------DTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFL---ETQAG 426
++AT D+G Y C+ +N G E S + V L P + L + G
Sbjct: 8013 NNVATLVFNQVDINDSGEYICKAENSVG-EVSASTFLTVQEQKLPPSFSRQLRDVQETVG 8071
Query: 427 LVGILHCSVV-SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETD 485
L + C++ SEP++ G + SP + N+ L I + +
Sbjct: 8072 LPVVFDCAISGSEPISVSWYKDGKPL--------KDSPNVQTSFLDNTATLNIFKTDRSL 8123
Query: 486 SGEYKCSATNSLGNATSTLDFHANAAR------LLISPAAEVVEGQAVTLSCRSGLSPTP 539
+G+Y C+ATN +G+A+S+ + + ++P VV G++ C ++ T
Sbjct: 8124 AGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVV-GESADFECH--VTGTQ 8180
Query: 540 DARFSWYLNGALLHEGP---------GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPA 590
+ SW + + G + L + D+G Y C A + S A
Sbjct: 8181 PIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVN--EVGKDSCTA 8238
Query: 591 VLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSG 650
L + P+FT RL + G L RV P + + + +
Sbjct: 8239 QLNIKERLIPPSFTKRLS-ETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPT---- 8293
Query: 651 GGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNA-STSATFNGQAT 709
S C ++T N L +++ + + GLY C+ SN G+A TS+ +
Sbjct: 8294 ---SNC-------EITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPK 8343
Query: 710 VLAIAPSH----TLQEGTEANLTCNVSREAAGSPANFSWFRNG----------VLWAQGP 755
+ H T+ EG L+C+V P W + G +A G
Sbjct: 8344 KPPVFDQHLTPVTVSEGEYVQLSCHVQ---GSEPIRIQWLKAGREIKPSDRCSFSFASGT 8400
Query: 756 LETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALF 815
+ L VA+ D+ Y C+ AG+ + S + D+P ++ LF
Sbjct: 8401 A-VLELRDVAKADSGDYVCKASNVAGSDTTK----SKVTIKDKPAVAPATKKAAVDGRLF 8455
Query: 816 -------ICTVDSRPLALLALFHGEHL----LATSLGPQVPSHGRFQAKAEANSLKLEVR 864
I V+ +A G+ + Q+ GR + + KLE+R
Sbjct: 8456 FVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIR 8515
Query: 865 ELGLGDSGSYRCEATNVLGSSNTSLFFQV 893
+ DSG YRC A N G +++ QV
Sbjct: 8516 DTTKTDSGLYRCVAFNEHGEIESNVNLQV 8544
Score = 72.0 bits (175), Expect = 5e-12
Identities = 94/411 (22%), Positives = 165/411 (40%), Gaps = 72/411 (17%)
Query: 146 SPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLE-TLHM 204
+PV+ + G DF C +V + +++ W +R + + K++ + +LE + H+
Sbjct: 8160 APVDAVVGESADFEC---HVTGTQPIKVSWAKD--SREIR-SGGKYQ---ISYLENSAHL 8210
Query: 205 AMSWQDHGRILRCQLSVANHRAQ----SEIHLQVKYAPKGVKILLSPSGRNILPGELVTL 260
+ D G + N + ++++++ + P LS + G L
Sbjct: 8211 TVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEET-EGNSFKL 8269
Query: 261 TCQVNSSYPAVSSIKWLKDGVRLQ----------TKTGVLHLPQAAWSDAGVYTCQAENG 310
+V S P ++ W K+ + +Q T VL + +A +DAG+YTC+ N
Sbjct: 8270 EGRVAGSQPI--TVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSND 8327
Query: 311 VGS-------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYK- 362
GS ++ P +F + ++P + E + V L C+ P +R W K
Sbjct: 8328 AGSALCTSSIVIKEPKKPPVF--DQHLTPV-TVSEGEYVQLSCHVQGSEP--IRIQWLKA 8382
Query: 363 -NHVLLEDAHSHT-------LRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLT 414
+ D S + L L +AD+G Y C+ NV GS+ + + + P +
Sbjct: 8383 GREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVA 8442
Query: 415 PVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGP--- 471
P +A + G L VSEP + V+ + G D P T G
Sbjct: 8443 PATK-----KAAVDGRLF--FVSEPQSIRVVEKTTATFIAKVG-GDPIPNVKWTKGKWRQ 8494
Query: 472 -------------NSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN 509
+ +LEIRD +TDSG Y+C A N G S ++ +
Sbjct: 8495 LNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVD 8545
Score = 57.4 bits (137), Expect = 1e-07
Identities = 156/754 (20%), Positives = 265/754 (35%), Gaps = 114/754 (15%)
Query: 227 QSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTK 286
+S HL+VK P+ + +L + GE T C++ SY + ++W G +L+
Sbjct: 12184 KSSAHLRVK--PRVIGLLRPLKDVTVTAGETATFDCEL--SYEDIP-VEWYLKGKKLEPS 12238
Query: 287 TGVLHLPQAAWSDAGVYTCQAEN-GVGSLVSPPISLH--IFMAEVQVSPAGPILENQTV- 342
V+ + + + E+ G L + H +F+ E V P LE+QTV
Sbjct: 12239 DKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKP-LEDQTVE 12297
Query: 343 -----TLVCNTPNEAPSDLRYSWYKN---------HVLLEDAHSHTLRLHLATRADTGFY 388
L C E + + W+KN + ++ D L +H T D Y
Sbjct: 12298 EGATAVLECEVSRE---NAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTY 12354
Query: 389 FCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHG 448
C+ ++ + S ++VV H LT L+ + + C + E G
Sbjct: 12355 TCDAKDF---KTSCNLNVVPPHVEFLRPLTD-LQVREKEMARFECELSRENAKVKWFKDG 12410
Query: 449 GHILASTSGDSDHSPRFSGTSGPNSLR-LEIRDLEETDSGEYKCSA-TNSLGNATSTLDF 506
I D ++R L I D EY C T + L+
Sbjct: 12411 AEIKKGKKYD---------IISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEE 12461
Query: 507 HANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGA---------LLHEGPG 557
A + L + EV E + L C P A WY +L EG
Sbjct: 12462 EAVFTKNLAN--IEVSETDTIKLVCEVS---KPGAEVIWYKGDEEIIETGRYEILTEGRK 12516
Query: 558 SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTR-LDLDAAGAGA 616
L++ A DAG+Y+CR PSS V F ++ +L+
Sbjct: 12517 RILVIQNAHLEDAGNYNCRL--------PSSRTDGKVKVHELAAEFISKPQNLEIL---E 12565
Query: 617 GRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEI 676
G + +C + S +Q D+ +L SG R+ V K
Sbjct: 12566 GEKAEFVCSI-SKESFPVQWKRDDK----TLESGDKYDVIADGKKRVLVVK--------- 12611
Query: 677 HNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAA 736
+ L++ G Y+ A A+ T + ++ ++E E C V+ E A
Sbjct: 12612 -DATLQDMGTYVVMVGAA--RAAAHLTVIEKLRIVVPLKDTRVKEQQEVVFNCEVNTEGA 12668
Query: 737 GSPANFSWFRNG---------VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTP 787
+ WFRN ++ + + T+ + D A Y + G + +
Sbjct: 12669 KA----KWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSA 12724
Query: 788 VLLSVLYPPDRPKLSALLDMG--QGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVP 845
L ++ D + L D+ + F C V+ + L +GE +VP
Sbjct: 12725 ANL-IVEEEDLRIVEPLKDIETMEKKSVTFWCKVNRLNVTLKWTKNGE---------EVP 12774
Query: 846 SHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPE 905
R + + L +++ G D G Y A + L + +V+
Sbjct: 12775 FDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAEL-LIIEAPTEFVEHLEDQT 12833
Query: 906 LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQE 939
+ E V SCQ+ E + +WYR+G+ ++E
Sbjct: 12834 VTEFDDAVFSCQLSR---EKANVKWYRNGREIKE 12864
Score = 51.2 bits (121), Expect = 8e-06
Identities = 140/761 (18%), Positives = 258/761 (33%), Gaps = 147/761 (19%)
Query: 231 HLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTK---- 286
HL V PK + L + + + E+ LTC V SS + W KDG +L+
Sbjct: 32711 HLPVSAPPKITQFLKAEASK-----EIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQ 32765
Query: 287 -------TGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPI--------SLHIFMAEV--- 328
T L + SD G Y C+ +G G + S+H ++++
Sbjct: 32766 FHYSADGTYELKINNLTESDQGEYVCEI-SGEGGTSKTNLQFMGQAFKSIHEKVSKISET 32824
Query: 329 --------------QVSPAGPI-----------LENQTVTL--VCNTPNEAPSDLRYS-- 359
+ P P L++ TV+ V +A + R +
Sbjct: 32825 KKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAI 32884
Query: 360 WYKN---------HVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNH 410
W K+ + L ED L +H +D+G Y C V+N GS S
Sbjct: 32885 WTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSS-------- 32936
Query: 411 PPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSG 470
+ A +T+A V S ++ +V S + S
Sbjct: 32937 --CKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEE-----ISQKALRSEEIKMSEAKS 32989
Query: 471 PNSLRLEIRDLEETDSGEYKCSATNSL----------GNATSTLDFHANAARLLISPAAE 520
L L+ + S E K SA SL + ++ + +A S
Sbjct: 32990 QEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMS 33049
Query: 521 VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH---------EGPGSSLLLPAASSTDAG 571
+ EGQ + L ++ ++ D + W LNG L G +L + AS D G
Sbjct: 33050 INEGQRLVL--KANIAGATDVK--WVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEG 33105
Query: 572 SYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPP 631
C ++ L+ P F ++ + G+ L C + +P
Sbjct: 33106 ILTCISKTKEGIVKCQYDLTLSKELSD-APAFISQ--PRSQNINEGQNVLFTCEISGEPS 33162
Query: 632 ARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEA 691
++ + ++ S + ++++ N+ +EI N + + G Y +A
Sbjct: 33163 PEIEWFKNNLPIS--------------ISSNVSISRSRNVYSLEIRNASVSDSGKYTIKA 33208
Query: 692 SNALGNASTSATFNGQATVLAIAPSHTLQEGTEANL-----TCNVSREAAGSPANFSWFR 746
N G S +A+ V + L+ + +L + +V A+ A+FS F
Sbjct: 33209 KNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFS 33268
Query: 747 NGVLWAQGPLETVTLLP----------VARTDAALYACRILTEAGAQLSTPVLLSVLYPP 796
+ + ++ ++ V + ++ +T+ + S + + P
Sbjct: 33269 SSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIP 33328
Query: 797 DRPKLSAL---LDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAK 853
PK+ AL + + +G + C P + G + + GRF +
Sbjct: 33329 --PKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQ------EQGRFHIE 33380
Query: 854 AEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894
+ L + ++ D G Y N GS + ++ +R
Sbjct: 33381 NTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 33421
Score = 47.0 bits (110), Expect = 2e-04
Identities = 189/907 (20%), Positives = 305/907 (33%), Gaps = 173/907 (19%)
Query: 131 TLVTVTEEPRVPTIASP---VELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFN 187
T VT E R+ + P VE+ G F + V QW+ + + + +
Sbjct: 11740 TKANVTVEARLIKVEKPLYGVEVFVGETAHFEIELS----EPDVHGQWKLKGQPLTASPD 11795
Query: 188 SQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANH------RAQSEIHLQVKYAPKGV 241
+ E G H+ LH CQL + A+S +L+VK P
Sbjct: 11796 CEIIED-GKKHILILH------------NCQLGMTGEVSFQAANAKSAANLKVKELPL-- 11840
Query: 242 KILLSP-SGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ-------TKTGVLH-- 291
I ++P S + + C+V+ + +WLK + K G H
Sbjct: 11841 -IFITPLSDVKVFEKDEAKFECEVSRE---PKTFRWLKGTQEITGDDRFELIKDGTKHSM 11896
Query: 292 -LPQAAWSDAGVYTCQAENG--VGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNT 348
+ AA+ D Y +AE+ G L+ I L ++P + + + V T
Sbjct: 11897 VIKSAAFEDEAKYMFEAEDKHTSGKLIIEGIRLKF------LTPLKDVTAKEKESAVF-T 11949
Query: 349 PNEAPSDLRYSWYKNHVLLEDAHSHTL----RLHLATRADTGFYFCEVQNVH--GSERSG 402
+ ++R W+KN L S ++ + H T D V G
Sbjct: 11950 VELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEA 12009
Query: 403 PVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSG--DSD 460
++V+ P T L + + V IL C + G I S + +D
Sbjct: 12010 KLTVLEGDPYFTGKLQDYTGVEKDEV-ILQCEISKADAPVKWFKDGKEIKPSKNAVIKAD 12068
Query: 461 HSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAE 520
R L ++ ++D G+Y C + LD +L + P
Sbjct: 12069 GKKRM----------LILKKALKSDIGQYTCDCGTD--KTSGKLDIEDREIKL-VRPLHS 12115
Query: 521 VVEGQAVTLSCRSGLSPTPDARFSWYLNGALL---------HEGPGSSLLLPAASSTDAG 571
V + T + +S D +W L G L EG SL+L G
Sbjct: 12116 VEVMETETARFETEISED-DIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTG 12174
Query: 572 SYHCRARDGHSASGPS-SPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVD-SD 629
+A + S++ P V+ +L P + T T AG C + D
Sbjct: 12175 GVDFQAANVKSSAHLRVKPRVIGLLRPLKDVTVT-----------AGETATFDCELSYED 12223
Query: 630 PPARLQLLHK-----DRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEE 684
P L K D+VV S + + + + LE+
Sbjct: 12224 IPVEWYLKGKKLEPSDKVVPRS---------------------EGKVHTLTLRDVKLEDA 12262
Query: 685 GLYLCEASNALGNASTSATFNGQATVLAIAP--SHTLQEGTEANLTCNVSREAAGSPANF 742
G A + +A+ F + V P T++EG A L C VSRE A
Sbjct: 12263 GEVQLTAKDFKTHANL---FVKEPPVEFTKPLEDQTVEEGATAVLECEVSRE----NAKV 12315
Query: 743 SWFRNGV---------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVL 793
WF+NG + A G + + + D Y C T L+V+
Sbjct: 12316 KWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTC-----DAKDFKTSCNLNVV 12370
Query: 794 YPPDRPKLSALLDM--GQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQ 851
PP L L D+ + MA F C + SR A + F G ++ ++
Sbjct: 12371 -PPHVEFLRPLTDLQVREKEMARFECEL-SRENAKVKWFKD--------GAEIKKGKKYD 12420
Query: 852 AKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQA 911
++ L + + L D Y CE S ++ + + + + E+ E
Sbjct: 12421 IISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTV-LEEEAVFTKNLANIEVSETDT 12479
Query: 912 VVLSCQVHTGVPEGTSYRWYRDGQPLQES------TSATLRFAAIT---LTQAGAYHCQA 962
+ L C+V G WY+ + + E+ T R I L AG Y+C
Sbjct: 12480 IKLVCEVS---KPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNC-- 12534
Query: 963 QAPGSAT 969
+ P S T
Sbjct: 12535 RLPSSRT 12541
Score = 47.0 bits (110), Expect = 2e-04
Identities = 105/501 (20%), Positives = 174/501 (34%), Gaps = 74/501 (14%)
Query: 1162 RPITLDVLYAPRNLRLTYLLESHG---GQLALVLCTVDSRPPAQLALSHAGRLLASSTAA 1218
+P TLD +APR +T + SH GQ + V S+P A++ H G L S+
Sbjct: 32366 QPFTLD--HAPR---ITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKI 32420
Query: 1219 SVPNT---LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGA 1275
NT L LE+ D G Y + G+A+ L + G E
Sbjct: 32421 HYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEV 32480
Query: 1276 PITVTCADPAAHAPTLYTWYHNGRWLQEGPAASL-SFLVATRAHAGAYSCQAQDAQGTRS 1334
P +V A + ++ + S + TR +Y A + +
Sbjct: 32481 PRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAA 32540
Query: 1335 SRPAALQVLYAPQ--DAVLSSFRDSRARSMAVIQ-------CTVDSEPPAELALSHDGKV 1385
+L+ + L++ ++ RSM V + C D EP + G+V
Sbjct: 32541 LEEKSLEEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQV 32600
Query: 1386 LATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQVEG 1444
L+TS+ V + ++ V A D+ Y +N G L ++
Sbjct: 32601 LSTSA--------RHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQK 32652
Query: 1445 ARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARA 1504
ARV + P + P P S A R EP
Sbjct: 32653 ARVTEKAVTSPPR----------VKSPEPRVKSPEAVKSPKRVKSPEP------------ 32690
Query: 1505 QAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASL 1564
H A PT + ++ L P + F++ E S+ +A L
Sbjct: 32691 ----SHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEA-----------SKEIAKL 32735
Query: 1565 TLHLGSRLVASSQ----PQGAPAEPHIHV---LASPNALRVDIEALRPSDQGEYICSASN 1617
T + S ++ + + G + + H ++ + I L SDQGEY+C S
Sbjct: 32736 TCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISG 32795
Query: 1618 VLGSASTSTYFGVRALHRLHQ 1638
G++ T+ F +A +H+
Sbjct: 32796 EGGTSKTNLQFMGQAFKSIHE 32816
Score = 45.4 bits (106), Expect = 5e-04
Identities = 61/293 (20%), Positives = 99/293 (33%), Gaps = 38/293 (12%)
Query: 810 GHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869
G FI V S+P A + +H G ++ + + L LE+ +
Sbjct: 32388 GQNTRFILNVQSKPTAEVKWYHN--------GVELQESSKIHYTNTSGVLTLEILDCHTD 32439
Query: 870 DSGSYRCEATN------------VLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQ 917
DSG+YR TN V G T+ Q R V S PEL +A +S
Sbjct: 32440 DSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSVFPELTRTEAYAVSSF 32499
Query: 918 VHTGVPE-GTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPI 976
T E +S R + + ++ +A ++ A ++ S T + +
Sbjct: 32500 KKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTL 32559
Query: 977 SLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEG 1036
+ + PR +T+ G C D +P + L ++++
Sbjct: 32560 AARILTKPRSMTVY------EGESARFSCDTDGEPVPTVTWLRKGQVLS----------- 32602
Query: 1037 SSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNV 1089
+S R V EI DEG Y N+ G+ A Q V
Sbjct: 32603 TSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARV 32655
Score = 44.7 bits (104), Expect = 8e-04
Identities = 72/349 (20%), Positives = 129/349 (36%), Gaps = 36/349 (10%)
Query: 187 NSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLS 246
NS+++ G +TL + + IL C + + L + +S
Sbjct: 33079 NSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFIS 33138
Query: 247 -PSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQA 295
P +NI G+ V TC++ S P+ I+W K+ + + + V L + A
Sbjct: 33139 QPRSQNINEGQNVLFTCEI-SGEPS-PEIEWFKNNLPISISSNVSISRSRNVYSLEIRNA 33196
Query: 296 AWSDAGVYTCQAENGVGS-----------LVSPPISLHIFMAEVQVSPAGPILENQTVTL 344
+ SD+G YT +A+N G LV P + S G +Q+V +
Sbjct: 33197 SVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGS-FSSQSVQM 33255
Query: 345 VCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRA---DTGFYFCEVQNVHGSERS 401
+ + S S + ++ A + + + F + N+ E S
Sbjct: 33256 SASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESS 33315
Query: 402 GPVSV---VVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGD 458
+ + PP L + + G V + C+ EP + S GG +
Sbjct: 33316 TSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKI-----H 33370
Query: 459 SDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFH 507
S RF + + L I D+++ D G Y S N G+ ++T++ H
Sbjct: 33371 SQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIH 33419
Score = 43.1 bits (100), Expect = 0.002
Identities = 143/705 (20%), Positives = 240/705 (34%), Gaps = 123/705 (17%)
Query: 426 GLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETD 485
G I C V T + G +I SP+ + +L I D++ +D
Sbjct: 11133 GSSAIFECLVSPSTAITTWMKDGSNIR--------ESPKHRFIADGKDRKLHIIDVQLSD 11184
Query: 486 SGEYKC--SATNSLGNATSTLDFHANAARLL--ISPAAEVVEGQAVTLSCRSGLSPTPDA 541
+GEY C N +T+ L R + + VV+GQ + LSC L+ D
Sbjct: 11185 AGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCE--LNKERDV 11242
Query: 542 RFSWYLNGALLHEGPG----------SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAV 591
W +G ++ E PG +L + A TDAG+Y + ++ S V
Sbjct: 11243 --VWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKV 11300
Query: 592 LTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGG 651
+ V+ R D G + C + D P D + A
Sbjct: 11301 VEVI---RDWLVKPIRDQHVKPKGT---AIFACDIAKDTPNIKWFKGYDEIPAEP----- 11349
Query: 652 GCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVL 711
+ + ++ + N L ++I N + E+ Y E G + G+ V
Sbjct: 11350 --------NDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIE---GKRYPAKLTLGEREVE 11398
Query: 712 AIAPSH--TLQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDA 769
+ P T+ E A+ +S A P W G L P
Sbjct: 11399 LLKPIEDVTIYEKESASFDAEISE--ADIPG--QWKLKGELLRPSP-------------- 11440
Query: 770 ALYACRILTEAGAQLST--PVLL----SVLYPPDRPKLSALLDMGQGHMALFI----CTV 819
C I E G + T V L VLY +A+L + + + + TV
Sbjct: 11441 ---TCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTV 11497
Query: 820 DSRPLALL-ALFHGEHLLATSLGPQ-VPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCE 877
R A + E + S GP + S +F A+ L + + D G Y E
Sbjct: 11498 PERRQARFECVLTREANVIWSKGPDIIKSSDKFDIIADGKKHILVINDSQFDDEGVYTAE 11557
Query: 878 ATNVLGSSNTSLFF--QVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQ 935
V G ++ F +R ++ ++EG+ C++ E W+++
Sbjct: 11558 ---VEGKKTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCELS---HEKMHVVWFKNDA 11611
Query: 936 PL---------QESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRH 986
L E + L +TL Q + L++ L V A +
Sbjct: 11612 KLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQVK-------ELSSTAQLKVLEADPY 11664
Query: 987 VTLTTLMDTGPGRLGLLL-CRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAV 1045
T+ T + + L C V D P + G+ +V SP+ +
Sbjct: 11665 FTVKLHDKTAVEKDEITLKCEVSKDVPVKW-FKDGEEIV------------PSPKYSIKA 11711
Query: 1046 APNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQ 1090
L+I A L+D+G Y+C+ + A+ +A+ + V+
Sbjct: 11712 DGLRRILKIKKADLKDKGEYVCDCGT--DKTKANVTVEARLIKVE 11754
Score = 42.7 bits (99), Expect = 0.003
Identities = 47/173 (27%), Positives = 71/173 (41%), Gaps = 18/173 (10%)
Query: 475 RLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR-----LLISPAAEVVEGQAVTL 529
+L I + + +SG Y ATN G ATST + A + + V +G V L
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRL 123
Query: 530 SCRSGLSPTPDARFSWYLNGA---------LLHEGPGSSLLLPAASSTDAGSYHCRARDG 580
R PTP +F Y +GA + EG SLL+ A D+G+Y A
Sbjct: 124 QVRVTGIPTPVVKF--YRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNAT-- 179
Query: 581 HSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPAR 633
+S +S A L V P T+ + A R+ + ++++ AR
Sbjct: 180 NSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDAR 232
Score = 42.7 bits (99), Expect = 0.003
Identities = 98/463 (21%), Positives = 168/463 (36%), Gaps = 59/463 (12%)
Query: 1052 LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWP---GATVREGQLVNLTC- 1107
L I+ + +DEGVY E SA + ++ TV+EG+ C
Sbjct: 11541 LVINDSQFDDEGVYTAEVEGK----KTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCE 11596
Query: 1108 -------LVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRL 1160
+VW + A+L + H + + VT+ D + + V L
Sbjct: 11597 LSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQV------KEL 11650
Query: 1161 SRPITLDVLYAPRNLRLTYLLESHGGQLALVL-CTVDSRPPAQLALSHAGRLLASSTAAS 1219
S L VL A + ++ + + L C V P + ++ S +
Sbjct: 11651 SSTAQLKVLEADPYFTVKLHDKTAVEKDEITLKCEVSKDVPVKW-FKDGEEIVPSPKYSI 11709
Query: 1220 VPNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGV-RVILAPEAAVPEGAP 1276
+ LR L+++ +D+G Y C + +AN ++E RL V + + E V E A
Sbjct: 11710 KADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIKVEKPLYGVEVFVGETAH 11769
Query: 1277 ITVTCADPAAHAPTLYTWYHNGRWLQEGPAASL------SFLVATRAH---AGAYSCQAQ 1327
+ ++P H W G+ L P + L+ G S QA
Sbjct: 11770 FEIELSEPDVHG----QWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAA 11825
Query: 1328 DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLA 1387
+A+ + + L +++ + + F A+ +C V EP L ++
Sbjct: 11826 NAKSAANLKVKELPLIFITPLSDVKVFEKDEAK----FECEVSREPKTFRWLKGTQEITG 11881
Query: 1388 TSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARV 1447
+ GT H V ++A +D + Y+ A++ T G+L +EG R+
Sbjct: 11882 -DDRFELIKDGTKHSMVIKSA---AFED----EAKYMFEAEDK----HTSGKLIIEGIRL 11929
Query: 1448 -VAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLH 1489
P DV A + N WF ND+RLH
Sbjct: 11930 KFLTPLKDV---TAKEKESAVFTVELSHDNIRVKWFKNDQRLH 11969
Score = 42.4 bits (98), Expect = 0.004
Identities = 42/167 (25%), Positives = 62/167 (37%), Gaps = 22/167 (13%)
Query: 930 WYRDGQPLQEST-----------SATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISL 978
W+RDGQ + ST A L A+T +G Y +A TS A +
Sbjct: 39 WFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVK 98
Query: 979 HVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSS 1038
+ P V M G L RV P ++ + S+L EG
Sbjct: 99 AETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDL 158
Query: 1039 PRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQ 1085
L +A A ED G Y A+N++G+A+++A+ Q
Sbjct: 159 YSLLIAEA-----------YPEDSGTYSVNATNSVGRATSTAELLVQ 194
Score = 42.0 bits (97), Expect = 0.005
Identities = 41/190 (21%), Positives = 68/190 (35%), Gaps = 25/190 (13%)
Query: 901 SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQES---------TSATLRFAAIT 951
S + EGQ +VL + T +W +G L S + TL +
Sbjct: 33045 STQMSINEGQRLVLKANI----AGATDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQAS 33100
Query: 952 LTQAGAYHCQAQAP-GSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSD 1010
G C ++ G +S +S AP ++ + G+ L C + +
Sbjct: 33101 HRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGE 33160
Query: 1011 PPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEAS 1070
P ++ + P S + ++ + N LEI A + D G Y +A
Sbjct: 33161 PSPEIEWFKNNL-----------PISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAK 33209
Query: 1071 NTLGQASASA 1080
N GQ SA+A
Sbjct: 33210 NFRGQCSATA 33219
Score = 41.2 bits (95), Expect = 0.009
Identities = 44/193 (22%), Positives = 77/193 (39%), Gaps = 31/193 (16%)
Query: 521 VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEG--PG---------SSLLLPAASSTD 569
V+EG T P P+ SW+ +G ++ PG + L +PA + +
Sbjct: 17 VLEGSTATFEAHISGFPVPEV--SWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKAN 74
Query: 570 AGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSD 629
+G Y +A +G + +S A L V P F RL G+ R L RV
Sbjct: 75 SGRYSLKATNGSGQA--TSTAELLVKAETAPPNFVQRLQSMTVRQGSQVR--LQVRVTGI 130
Query: 630 PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLC 689
P ++ + +SL ++++ +L + I E+ G Y
Sbjct: 131 PTPVVKFYRDGAEIQSSLD--------------FQISQEGDLYSLLIAEAYPEDSGTYSV 176
Query: 690 EASNALGNASTSA 702
A+N++G A+++A
Sbjct: 177 NATNSVGRATSTA 189
Score = 41.2 bits (95), Expect = 0.009
Identities = 30/111 (27%), Positives = 51/111 (45%), Gaps = 11/111 (9%)
Query: 398 SERSGPVSVVVNHPP----LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILA 453
SE S PV+++ + P L+ + + L +AG L +V +P+ T+ G +L
Sbjct: 19278 SEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLK 19337
Query: 454 STSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTL 504
G R N LE+ + DSG+Y +A NS G+ ++T+
Sbjct: 19338 PAEGIKMAMQR-------NLCTLELFSVNRKDSGDYTITAENSSGSKSATI 19381
Score = 40.4 bits (93), Expect = 0.015
Identities = 44/189 (23%), Positives = 75/189 (39%), Gaps = 26/189 (13%)
Query: 721 EGTEANLTCNVSREAAGSPA-NFSWFRNGVLWAQGPLETV-----------TLLPVARTD 768
EG+ A ++S G P SWFR+G + + L V T+ V + +
Sbjct: 19 EGSTATFEAHIS----GFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKAN 74
Query: 769 AALYACRILTEAGAQLSTPVLL--SVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLAL 826
+ Y+ + +G ST LL + PP+ + + + QG V P +
Sbjct: 75 SGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPV 134
Query: 827 LALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN 886
+ + G ++ S FQ E + L + E DSG+Y ATN +G +
Sbjct: 135 VKFYRD--------GAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRAT 186
Query: 887 TSLFFQVRG 895
++ V+G
Sbjct: 187 STAELLVQG 195
Score = 40.0 bits (92), Expect = 0.019
Identities = 70/336 (20%), Positives = 133/336 (39%), Gaps = 46/336 (13%)
Query: 68 QVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSD 127
+V+ + D +++E GR E + R+ L++++ ED+G+YN R S +
Sbjct: 12492 EVIWYKGDEEIIET---GRYEILTEGRKRI--LVIQNAHLEDAGNYNCRLPSSRTDGKVK 12546
Query: 128 VKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFN 187
V +P+ +E+LEG + +F CS +E +QW+ D +
Sbjct: 12547 VHELAAEFISKPQ------NLEILEGEKAEFVCSIS----KESFPVQWKRDDKTLE---S 12593
Query: 188 SQKFEPTGVGHLETLHMA-MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLS 246
K++ G L + + QD G + V A++ HL V + ++I++
Sbjct: 12594 GDKYDVIADGKKRVLVVKDATLQDMGTYV-----VMVGAARAAAHLTV---IEKLRIVVP 12645
Query: 247 PSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDG----------VRLQTKTGVLHLPQAA 296
+ + V C+VN+ + KW ++ + + L + A
Sbjct: 12646 LKDTRVKEQQEVVFNCEVNTE---GAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAH 12702
Query: 297 WSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQ-VSPAGPI--LENQTVTLVCNTPNEAP 353
D Y N G V +L + +++ V P I +E ++VT C N
Sbjct: 12703 LDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKV-NRLN 12761
Query: 354 SDLRYSWYKNHVLLEDAHSHTL--RLHLATRADTGF 387
L+++ V ++ S+ + H+ T D GF
Sbjct: 12762 VTLKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGF 12797
Score = 38.9 bits (89), Expect = 0.043
Identities = 52/246 (21%), Positives = 97/246 (39%), Gaps = 59/246 (23%)
Query: 48 DVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEAR-FRGRTEFMGNPEHRVC------NL 100
D+EVP+ YSG+ + + P+ +E + + E N ++ + NL
Sbjct: 2275 DIEVPES--------YSGELECI---VSPENIEGKWYHNDVELKSNGKYTITSRRGRQNL 2323
Query: 101 LLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNC 160
+KD+ ED G Y+F D K T + +PR P+ +L+G C
Sbjct: 2324 TVKDVTKEDQGEYSFVI---------DGKKTTCKLKMKPR------PIAILQGLSDQKVC 2368
Query: 161 STPYVCLQEQVRLQ-----WQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRIL 215
V L+ +V L+ W + Q+ +P+ + +H+ + Q H ++
Sbjct: 2369 EGDIVQLEVKVSLESVEGVWMK---------DGQEVQPS-----DRVHIVIDKQSHMLLI 2414
Query: 216 R--CQLSVANHR---AQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPA 270
+ N+ + + + V ++ N++ G L C+V S P
Sbjct: 2415 EDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLKDVNVIEGTKAVLECKV--SVPD 2472
Query: 271 VSSIKW 276
V+S+KW
Sbjct: 2473 VTSVKW 2478
Score = 38.9 bits (89), Expect = 0.043
Identities = 38/165 (23%), Positives = 63/165 (38%), Gaps = 19/165 (11%)
Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTA---ASVPNTLRLELRGPQPRDEGFYSCS 1242
G+ A + C + RP + G+ L S +S T L + + DEG Y+C
Sbjct: 30547 GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCI 30606
Query: 1243 ARSPLGQANTSLELRLEGVRVI-----LAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN 1297
A + +G+ TS +L L+ L + G+ + + P + TW+H
Sbjct: 30607 ATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAM-TWFHG 30665
Query: 1298 GRWLQEGPAASLSFL----------VATRAHAGAYSCQAQDAQGT 1332
+ LQ ++ V + HAG Y Q + GT
Sbjct: 30666 QKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGT 30710
Score = 38.5 bits (88), Expect = 0.057
Identities = 78/325 (24%), Positives = 111/325 (34%), Gaps = 54/325 (16%)
Query: 252 ILPGELVTLTCQVNSSYPAVSSIKWLKDGVR-----------LQTKTGVLHLPQAAWSDA 300
IL G VT C++ S YP + I W KDG R LQ L +P D
Sbjct: 1302 ILEGMGVTFHCKM-SGYP-LPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDE 1359
Query: 301 GVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSW 360
G+YT A N G+ I ++ V PA P L T + S S
Sbjct: 1360 GIYTAFASNIKGNA--------ICSGKLYVEPAAP-LGAPTYIPTLEPVSRIRSLSPRSV 1410
Query: 361 YKNHVLLEDAHSHTLRLHLA----TRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPV 416
++ + + A R+ A R G E PV V L PV
Sbjct: 1411 SRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQLERLYKPVFV------LKPV 1464
Query: 417 LTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP--RFSGTSGPNSL 474
LE Q + VV P+ H G + + D H + GT
Sbjct: 1465 SFKCLEGQTARFDL---KVVGRPMPETFWFHDGQQIVN---DYTHKVVIKEDGTQS---- 1514
Query: 475 RLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA-------AEVVEGQAV 527
L I +DSGE+ A N G ++ ++ A + P + EG +
Sbjct: 1515 -LIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRL 1573
Query: 528 TLSCRSGLSPTPDARFSWYLNGALL 552
+ R+ +P PD W N ++
Sbjct: 1574 EMKVRATGNPNPD--IVWLKNSDII 1596
Score = 37.7 bits (86), Expect = 0.096
Identities = 70/362 (19%), Positives = 130/362 (35%), Gaps = 49/362 (13%)
Query: 1299 RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQG-TRSSRPAALQVLYAPQDAVLSSFRDS 1357
R+ G +L+ A+ G +C ++ +G + L + A +S R
Sbjct: 33084 RYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQ 33143
Query: 1358 RARS--MAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQD 1415
+ C + EP E+ + ++ SS V + +RN L++++
Sbjct: 33144 NINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVS--------ISRSRNVYSLEIRN 33195
Query: 1416 VPAGDD-TYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVP---------EGAALNLSC 1465
D Y A+N G S L V +V EP +V +G+ + S
Sbjct: 33196 ASVSDSGKYTIKAKNFRGQCSATASLMV--LPLVEEPSREVVLRTSGDTSLQGSFSSQSV 33253
Query: 1466 RLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHV-ARAQAGMYHCLAELPTGA----- 1519
++ S+F+ A + + F + A++ + M E+ + +
Sbjct: 33254 QMSASKQEASFSSFS------SSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGIS 33307
Query: 1520 -----AASAPVMLRVLY---PPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSR 1571
+S ML+ PPK + + + G + C EP +T G R
Sbjct: 33308 NMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGR 33367
Query: 1572 LVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
+ SQ QG H+ + + + I ++ D G Y S N GS S + +R
Sbjct: 33368 KI-HSQEQG-----RFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 33421
Query: 1632 AL 1633
++
Sbjct: 33422 SI 33423
Score = 37.7 bits (86), Expect = 0.096
Identities = 62/317 (19%), Positives = 121/317 (38%), Gaps = 42/317 (13%)
Query: 1226 LELRGPQPRDEGFYSCSARSPLGQANTSLELRL-----EGVRVILAPEAA-VPEGAPITV 1279
L ++ RDEG +C +++ G +L L + I P + + EG +
Sbjct: 33094 LTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLF 33153
Query: 1280 TCADPAAHAPTLYTWYHNGRWLQEGPAASLS---------FLVATRAHAGAYSCQAQDAQ 1330
TC +P + W+ N + S+S A+ + +G Y+ +A++ +
Sbjct: 33154 TCEISGEPSPEI-EWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFR 33212
Query: 1331 GTRSSRPAALQVL----YAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVL 1386
G + S A+L VL ++ VL + D+ + Q S E + S
Sbjct: 33213 G-QCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSS 33271
Query: 1387 ATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGA- 1445
A+S AS + + ++++ ++ + + L S S + + + G
Sbjct: 33272 ASSMTEMKFASMSAQ---SMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIP 33328
Query: 1446 -RVVAEPG-LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA-----------EP 1492
++ A P + + EG L ++C G P P W R++H+ +
Sbjct: 33329 PKIEALPSDISIDEGKVLTVACAFTGEPTP----EVTWSCGGRKIHSQEQGRFHIENTDD 33384
Query: 1493 VPTLAFTHVARAQAGMY 1509
+ TL V + G+Y
Sbjct: 33385 LTTLIIMDVQKQDGGLY 33401
Score = 37.4 bits (85), Expect = 0.13
Identities = 62/269 (23%), Positives = 91/269 (33%), Gaps = 49/269 (18%)
Query: 1225 RLELRGPQ--PRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCA 1282
R LR P P DEG Y+ A + G A S +L + E A P GAP +
Sbjct: 1346 RASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYV---------EPAAPLGAPTYIPTL 1396
Query: 1283 DPAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTR--SSRPAAL 1340
+P + +L + R + P ++ + A A+ + G R + + L
Sbjct: 1397 EPVSRIRSL-----SPRSVSRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQL 1451
Query: 1341 QVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDG---------KVLATSSG 1391
+ LY P + A V P E HDG KV+ G
Sbjct: 1452 ERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDG 1511
Query: 1392 VHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEP 1451
SL + V P+ + AQN G S L VE +P
Sbjct: 1512 TQSL---------------IIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKP 1556
Query: 1452 -------GLDVPEGAALNLSCRLLGGPGP 1473
+++ EG+ L + R G P P
Sbjct: 1557 MFVEKLKNVNIKEGSRLEMKVRATGNPNP 1585
Score = 36.6 bits (83), Expect = 0.21
Identities = 30/122 (24%), Positives = 51/122 (41%), Gaps = 15/122 (12%)
Query: 849 RFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE 908
+F+ + + L V+ L D G+YR + S+ ++ + AW + L+E
Sbjct: 8702 KFEISIDGDRHTLRVKNCQLKDQGNYRLVCGPHIASAKLTV---IEPAWERHLQDVTLKE 8758
Query: 909 GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQ---------ESTSATLRFAAITLTQAGAYH 959
GQ ++CQ VP S W+R+G+ L+ E L A + G Y
Sbjct: 8759 GQTCTMTCQF--SVPNVKS-EWFRNGRILKPQGRHKTEVEHKVHKLTIADVRAEDQGQYT 8815
Query: 960 CQ 961
C+
Sbjct: 8816 CK 8817
Score = 36.2 bits (82), Expect = 0.28
Identities = 61/294 (20%), Positives = 103/294 (35%), Gaps = 49/294 (16%)
Query: 286 KTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGP-----ILENQ 340
K +L + + + D GVYT + E S +F+ +++ P + E +
Sbjct: 11537 KKHILVINDSQFDDEGVYTAEVEG-------KKTSARLFVTGIRLKFMSPLEDQTVKEGE 11589
Query: 341 TVTLVCNTPNEAPSDLRYSWYKNHVLLE---------DAHSHTLRLHLATRADTGFYFCE 391
T T VC +E + W+KN L + +H L + T D +
Sbjct: 11590 TATFVCELSHEK---MHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQ 11646
Query: 392 VQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHI 451
V+ + + + + V+ P T L + + L C V S+ + G I
Sbjct: 11647 VKELSSTAQ---LKVLEADPYFTVKLHDKTAVEKDEI-TLKCEV-SKDVPVKWFKDGEEI 11701
Query: 452 LASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAA 511
+ S P++S + L+I+ + D GEY C A T++ A
Sbjct: 11702 VPS--------PKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVE-----A 11748
Query: 512 RLLISP----AAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLL 561
RL+ EV G+ PD W L G L P ++
Sbjct: 11749 RLIKVEKPLYGVEVFVGETAHFEIELS---EPDVHGQWKLKGQPLTASPDCEII 11799
Score = 36.2 bits (82), Expect = 0.28
Identities = 43/209 (20%), Positives = 79/209 (37%), Gaps = 32/209 (15%)
Query: 718 TLQEGTEANLTCNVSREAAGSPA-NFSWFRNGV---------LWAQGPLETVTLLPVART 767
T + G A L+C + G P + W+R G + + G T+T++ +
Sbjct: 30543 TTKLGEAAQLSCQI----VGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQE 30598
Query: 768 DAALYACRILTEAG-AQLSTPVLLSVL--YPPDRPKLSALLDMGQGHMALFICTVDSRPL 824
D +Y C E G + S+ +LL + P P + L + + RP+
Sbjct: 30599 DEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYI-GRPV 30657
Query: 825 ALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGS 884
+ FHG+ LL S + + + N + +G Y+ + +NV G+
Sbjct: 30658 PAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKT-------HAGKYKVQLSNVFGT 30710
Query: 885 SNTSLFFQVRGAWVQVSPSPELQEGQAVV 913
+ L V++ P+ G V+
Sbjct: 30711 VDAILD-------VEIQDKPDKPTGPIVI 30732
Score = 36.2 bits (82), Expect = 0.28
Identities = 32/148 (21%), Positives = 59/148 (39%), Gaps = 12/148 (8%)
Query: 362 KNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFL 421
+ + + D +HTL + + D G Y C N G + ++ P P
Sbjct: 30577 RKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGY-PLK 30635
Query: 422 ETQAGLVGI---LHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEI 478
E G VG LH + P+ + HG +L +S + + + L +
Sbjct: 30636 EKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLL-------QNSENITIENTEHYTHLVM 30688
Query: 479 RDLE-ETDSGEYKCSATNSLGNATSTLD 505
++++ +T +G+YK +N G + LD
Sbjct: 30689 KNVQRKTHAGKYKVQLSNVFGTVDAILD 30716
Score = 35.8 bits (81), Expect = 0.37
Identities = 57/231 (24%), Positives = 81/231 (35%), Gaps = 23/231 (9%)
Query: 672 LRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNV 731
LR+ + P E+EG+Y ASN GNA S L + P+ L T V
Sbjct: 1349 LRIPVVLP--EDEGIYTAFASNIKGNAICSGK-------LYVEPAAPLGAPTYIPTLEPV 1399
Query: 732 SREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLS 791
SR + SP + S R+ + + + + P + A + R L E L
Sbjct: 1400 SRIRSLSPRSVS--RSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDES-----QLE 1452
Query: 792 VLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQ 851
LY P +G A F V RP+ FH + +V
Sbjct: 1453 RLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKV------- 1505
Query: 852 AKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSP 902
E + L + DSG + A N G S+ S+ V QV P
Sbjct: 1506 VIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKP 1556
Score = 35.8 bits (81), Expect = 0.37
Identities = 41/171 (23%), Positives = 67/171 (39%), Gaps = 34/171 (19%)
Query: 255 GELVTLTCQVNSSYPAVSSIKWLKDGVRL----------QTKTGVLHLPQAAWSDAGVYT 304
GE L+CQ+ + IKW + G L +T L + D GVYT
Sbjct: 30547 GEAAQLSCQIVGR--PLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYT 30604
Query: 305 CQAENGVGSLVSPPISLHIFMAEVQVSPAGPILE------NQTVTL-VCNTPNEAPSDLR 357
C A N VG + + S + A Q P P+ E T+ L V P+
Sbjct: 30605 CIATNEVGEVETS--SKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPA--- 30659
Query: 358 YSWYKNHVLLEDA----------HSHTLRLHLATRADTGFYFCEVQNVHGS 398
+W+ LL+++ ++H + ++ + G Y ++ NV G+
Sbjct: 30660 MTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGT 30710
Score = 34.7 bits (78), Expect = 0.82
Identities = 32/128 (25%), Positives = 50/128 (39%), Gaps = 25/128 (19%)
Query: 408 VNHPPLT--PVLTAFLETQAGL-VGILHCSVVSEPLATLV---------LSHGGHILAST 455
V H P++ P +T FL+ +A + L C V S L L GH
Sbjct: 32709 VQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHY 32768
Query: 456 SGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLI 515
S D + L+I +L E+D GEY C + G + + L F A + +
Sbjct: 32769 SADGTYE-------------LKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIH 32815
Query: 516 SPAAEVVE 523
+++ E
Sbjct: 32816 EKVSKISE 32823
Score = 33.9 bits (76), Expect = 1.4
Identities = 25/113 (22%), Positives = 48/113 (42%), Gaps = 9/113 (7%)
Query: 782 AQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLG 841
A++ PV + V PP + + +G C + P + + ++ + +S+
Sbjct: 930 ARVPAPVEIPVT-PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSID 988
Query: 842 PQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894
FQ ++ +L +RE DSG + C A N G+ +TS + V+
Sbjct: 989 --------FQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 1033
Score = 33.9 bits (76), Expect = 1.4
Identities = 26/90 (28%), Positives = 49/90 (54%), Gaps = 18/90 (20%)
Query: 252 ILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQT--------KTGV--LHLPQAAWSDAG 301
++ GE VTL C + S YP+ ++ W ++ ++++ ++G+ L + +A D+G
Sbjct: 954 VIEGESVTLECHI-SGYPS-PTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSG 1011
Query: 302 VYTCQAENGVGSLVSPPISLHIFMAEVQVS 331
+TC A N G+ +S ++A VQVS
Sbjct: 1012 RFTCSAVNEAGT-----VSTSCYLA-VQVS 1035
Score = 33.9 bits (76), Expect = 1.4
Identities = 22/74 (29%), Positives = 32/74 (43%), Gaps = 13/74 (17%)
Query: 273 SIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLH 322
+I W+KDG L+ T V LH+ + D G YT A N G+ +L
Sbjct: 24342 NISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATE---NLS 24398
Query: 323 IFMAEVQVSPAGPI 336
+ + E P GP+
Sbjct: 24399 VIVLEKPGPPVGPV 24412
Score = 33.9 bits (76), Expect = 1.4
Identities = 47/218 (21%), Positives = 74/218 (33%), Gaps = 33/218 (15%)
Query: 1070 SNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL 1129
++T+ +F N + G VR G + T HP + TWY+ GQ+
Sbjct: 31680 TDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTI-------TVHP-EPHVTWYKSGQKIK 31731
Query: 1130 DA--------------HSIPLPNVTVRDATSY----RCGVGPPGRAPRLS---RPITLDV 1168
+ + + +VT D Y R G +L+ P D
Sbjct: 31732 PGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDS 31791
Query: 1169 LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT----L 1224
P RL E GQ V PP L G+ L+ + +
Sbjct: 31792 TLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYY 31851
Query: 1225 RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVR 1262
L +R P D G+Y +A + G + L++E +R
Sbjct: 31852 ALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVERLR 31889
Score = 33.1 bits (74), Expect = 2.4
Identities = 30/119 (25%), Positives = 46/119 (38%), Gaps = 9/119 (7%)
Query: 1513 AELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRL 1572
A++ A APV + V PP + + V G L+C + P ++T +
Sbjct: 924 AKVTETARVPAPVEIPVT-PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQ 982
Query: 1573 VASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
+ SS + R+ I D G + CSA N G+ STS Y V+
Sbjct: 983 IESSID--------FQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 1033
Score = 33.1 bits (74), Expect = 2.4
Identities = 38/171 (22%), Positives = 68/171 (39%), Gaps = 35/171 (20%)
Query: 272 SSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISL 321
+++ W KDG L+ T V L + +A+ D G Y N GS ++ PI++
Sbjct: 25424 ATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGS-ITVPITI 25482
Query: 322 HIFMAEVQVSPAGPI----LENQTVTLVCNTPN------------EAPSDLRYSWYKNHV 365
+ + P GPI + ++T+ N P E +W H+
Sbjct: 25483 IVL---DRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTW---HI 25536
Query: 366 LLEDAHSHTLRL-HLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTP 415
+ + ++++ L T ++ F C +N +G S VV P +P
Sbjct: 25537 VSQAVARTSIKIVRLTTGSEYQFRVC-AENRYGKSSYSESSAVVAEYPFSP 25586
Score = 32.7 bits (73), Expect = 3.1
Identities = 43/195 (22%), Positives = 74/195 (37%), Gaps = 22/195 (11%)
Query: 767 TDAALYACRILTE----AGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSR 822
T+ A+Y R++ E G + T + PP P L D+ Q +L +
Sbjct: 24180 TEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEHD 24239
Query: 823 PLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVL 882
G +L + Q ++ AE+ V L G +R +A N
Sbjct: 24240 G--------GSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEK 24291
Query: 883 GSSNTSLF-FQVRGAWVQVSPSPEL-------QEGQAVVLSCQVHTGVPEGTSYRWYRDG 934
G S+ + V + + PS +L Q G+ + + V G P + W +DG
Sbjct: 24292 GKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPV-IGRPR-PNISWVKDG 24349
Query: 935 QPLQESTSATLRFAA 949
+PL+++T + A
Sbjct: 24350 EPLKQTTRVNVEETA 24364
Score = 32.7 bits (73), Expect = 3.1
Identities = 38/149 (25%), Positives = 56/149 (37%), Gaps = 16/149 (10%)
Query: 362 KNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPP-----LTPV 416
K + D + L ++ T D Y +N +G + V HPP L P+
Sbjct: 31737 KKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPM 31796
Query: 417 ---LTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILA-STSGDSDHSPRFSGTSGPN 472
L A E Q G V P TL G L+ + + H G +
Sbjct: 31797 FKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHE-------GLD 31849
Query: 473 SLRLEIRDLEETDSGEYKCSATNSLGNAT 501
L IRD D+G Y+ +ATN+ G+ +
Sbjct: 31850 YYALHIRDTLPEDTGYYRVTATNTAGSTS 31878
Score = 32.7 bits (73), Expect = 3.1
Identities = 27/74 (36%), Positives = 36/74 (48%), Gaps = 9/74 (12%)
Query: 434 SVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSA 493
+V S+P A + H G L +S ++ TSG L LEI D DSG Y+
Sbjct: 32396 NVQSKPTAEVKWYHNGVELQESS-----KIHYTNTSGV--LTLEILDCHTDDSGTYRAVC 32448
Query: 494 TNSLGNAT--STLD 505
TN G A+ +TLD
Sbjct: 32449 TNYKGEASDYATLD 32462
Score = 32.3 bits (72), Expect = 4.1
Identities = 23/86 (26%), Positives = 35/86 (40%), Gaps = 2/86 (2%)
Query: 472 NSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLI--SPAAEVVEGQAVTL 529
N L IRD+ DS A N G +S A +L+ +VV + T+
Sbjct: 2132 NVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTM 2191
Query: 530 SCRSGLSPTPDARFSWYLNGALLHEG 555
+ + P + WY +G +HEG
Sbjct: 2192 ATFECETSEPFVKVKWYKDGMEVHEG 2217
Score = 32.3 bits (72), Expect = 4.1
Identities = 24/100 (24%), Positives = 43/100 (43%), Gaps = 13/100 (13%)
Query: 849 RFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQV-----------RGAW 897
++ +++ +L + + D Y A N G + V R +
Sbjct: 31738 KYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMF 31797
Query: 898 VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL 937
++ + E QEGQ+V +V +G+P T +W +DGQPL
Sbjct: 31798 KRLLANAECQEGQSVCFEIRV-SGIPPPT-LKWEKDGQPL 31835
Score = 32.3 bits (72), Expect = 4.1
Identities = 27/118 (22%), Positives = 53/118 (44%), Gaps = 12/118 (10%)
Query: 1332 TRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDS--EPPAELALSHDGKVLATS 1389
TR + P A + + + + +++ +D+ S +V + V + EP + DGK + T
Sbjct: 32837 TRKTEPKAPEPI-SSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAI-TQ 32894
Query: 1390 SGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQVEGAR 1446
G + L+ G L++ D Y CT +N GS+S+ +L ++ +
Sbjct: 32895 GGKYKLSEDKG-------GFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIK 32945
Score = 32.0 bits (71), Expect = 5.3
Identities = 32/156 (20%), Positives = 60/156 (38%), Gaps = 15/156 (9%)
Query: 48 DVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQP 107
DV + +G T +S + ++++ + R +TE EH+V L + D++
Sbjct: 8753 DVTLKEGQTCTMTCQFSVPNVKSEWFRNGRILKPQGRHKTEV----EHKVHKLTIADVRA 8808
Query: 108 EDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCL 167
ED G Y ++E E + ++ + T+ R+ I + E F C +
Sbjct: 8809 EDQGQYTCKYEDLETSAELRIEAEPIQFTK--RIQNIV----VSEHQSATFECEVSF--- 8859
Query: 168 QEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLH 203
+ + W + P F G H T+H
Sbjct: 8860 -DDAIVTWY-KGPTELTESQKYNFRNDGRCHYMTIH 8893
Score = 32.0 bits (71), Expect = 5.3
Identities = 38/158 (24%), Positives = 58/158 (36%), Gaps = 13/158 (8%)
Query: 1473 PVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVML----- 1527
P G AW R+ + V L FT + G Y + A S P
Sbjct: 16055 PTGTKKEAW----RQCNKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCD 16110
Query: 1528 --RVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEP 1585
R PP + F+E E G + ++ P +LT ++ + +
Sbjct: 16111 CQRPDMPPSID-LKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNK-EPVLYDT 16168
Query: 1586 HIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSAS 1623
H++ L + + I R SD G Y +A N LG+AS
Sbjct: 16169 HVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTAS 16206
Score = 32.0 bits (71), Expect = 5.3
Identities = 17/40 (42%), Positives = 23/40 (57%), Gaps = 1/40 (2%)
Query: 1060 EDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVRE 1099
EDEGVY C A+N +G+ S+ QA Q PG ++E
Sbjct: 30598 EDEGVYTCIATNEVGEVETSSKLLLQA-TPQFHPGYPLKE 30636
Score = 31.2 bits (69), Expect = 9.0
Identities = 16/53 (30%), Positives = 27/53 (50%), Gaps = 10/53 (18%)
Query: 271 VSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTCQAENGVGS 313
V ++ W KDG ++ + L +P++ +DAG+YT EN +GS
Sbjct: 14415 VPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGS 14467
Score = 31.2 bits (69), Expect = 9.0
Identities = 21/81 (25%), Positives = 33/81 (40%), Gaps = 7/81 (8%)
Query: 423 TQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLE 482
T+ G L C +V PL + G L S ++ +S + L + E
Sbjct: 30544 TKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ-------SRKYKMSSDGRTHTLTVMTEE 30596
Query: 483 ETDSGEYKCSATNSLGNATST 503
+ D G Y C ATN +G ++
Sbjct: 30597 QEDEGVYTCIATNEVGEVETS 30617
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 185 bits (470), Expect = 3e-46
Identities = 415/1794 (23%), Positives = 636/1794 (35%), Gaps = 327/1794 (18%)
Query: 18 QASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSADPK 77
Q G VQG G CL P P VEV + + R VS S
Sbjct: 1652 QCGPGYVGNPSVQG--GQCL--PETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHY 1707
Query: 78 LVEARFRGRTEFMGNPE-HRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVT 136
+R GR G + H+ L +QP D+G Y + S + + VT
Sbjct: 1708 FYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAE---LLVT 1764
Query: 137 EEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQ----VRLQW----QGQDPARSVTFNS 188
E P P I VE V ++C + L W G+ P R++ FN
Sbjct: 1765 EAPSKP-ITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFN- 1822
Query: 189 QKFEPTGVGHLETLHMAMSWQDHGRILRCQLSV-ANHRAQSEIHLQVKYAPKGVKILLSP 247
G L ++ +S D G + ++ A + + +H+Q + + P
Sbjct: 1823 --------GILTIRNVQLS--DAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHP 1872
Query: 248 SGRNILPGELVTLTCQVNSSYPAVSSIKWL-KDGVRLQTKT----GVLHLPQAAWSDAGV 302
+ PG+L C S +++W G +L K G+L LP +D
Sbjct: 1873 PQLTVQPGQLAEFRCSATGS--PTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQ 1930
Query: 303 YTCQAENGVGSLVSPPISLHIFMA---EVQVSP-AGPILENQTVTLVCNTPNEAPSDLRY 358
Y C+A + G V+ + LH+ VQVSP + +TV L C + +
Sbjct: 1931 YLCRAHSSAGQQVARAV-LHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATI-- 1987
Query: 359 SWYKNHVLL------EDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVN--- 409
+W K L E TL + T AD GFY C + G+ ++ VV++
Sbjct: 1988 TWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASD 2047
Query: 410 -HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGT 468
PP + ++ G L+C V A + G L P +
Sbjct: 2048 ASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSL----------PPHTQV 2097
Query: 469 SGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD---FHANAARLLISP-------- 517
G RL + + DSGEY C N G +++ H + +P
Sbjct: 2098 HGS---RLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPI 2154
Query: 518 -----AAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALL---HEGPGSSLLLPAASSTD 569
++ V EGQ + L+C + A+ +W+ G L H+ GS L L + D
Sbjct: 2155 RIEPSSSHVAEGQTLDLNC--VVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPAD 2212
Query: 570 AGSYHCRARDGHSASGPSSPAVLTVLYPP--RQPTFTTRLDLDAAGAGAGRRGLLLCRVD 627
+G Y C SGP +VL + P R++ ++ G+ L C V
Sbjct: 2213 SGEYVCHV---VGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVA 2269
Query: 628 SDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLY 687
A++ + GG P + R+ I + G Y
Sbjct: 2270 GQAHAQVTWYKR-----------------GGSLPARHQVRGS---RLYIFQASPADAGQY 2309
Query: 688 LCEASNALGNASTSATFNGQATVLA----------IAPSHT-LQEGTEANLTCNVSREAA 736
+C ASN + + T Q LA I PS + + EG +L C V +
Sbjct: 2310 VCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQ-- 2367
Query: 737 GSPANFSWFRNG---VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVL 793
S A +W + G + Q + L + D+ Y CR+L + L VL+++
Sbjct: 2368 -SHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVL-GSSVPLEASVLVTIE 2425
Query: 794 YPPDRPKL----SALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSH-- 847
P L + ++ +A + + L L L G+ QV H
Sbjct: 2426 PAGSVPALGVTPTVRIESSSSQVA------EGQTLDLNCLVAGQ------AHAQVTWHKR 2473
Query: 848 -GRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR----GAWVQ--- 899
G A+ + + +L + ++ DSG Y C G+ S+ ++ G+ Q
Sbjct: 2474 GGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVA 2533
Query: 900 -----VSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL---QESTSATLRFAAIT 951
S S L G + L+C V + P + WY+ G L + + LR +T
Sbjct: 2534 YPVRIESSSASLANGHTLDLNCLVASQAPH--TITWYKRGGSLPSRHQIVGSRLRIPQVT 2591
Query: 952 LTQAGAYHCQ-AQAPGSATTSLAAPI----SLHVSYAPRHVTLTTLMDT-GPGRLGLLLC 1005
+G Y C + GS TSL I S HV + + + T G+ L C
Sbjct: 2592 PADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNC 2651
Query: 1006 RVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVY 1065
V P A ++ +G GS P H + L +H + D G Y
Sbjct: 2652 VVARQPQA---------IITWYKRG-----GSLPSRH---QTHGSHLRLHQMSVADSGEY 2694
Query: 1066 ICEASNTLGQASASADFD-AQAVNVQVWPGAT-----------VREGQLVNLTCLVWTTH 1113
+C A+N + AS + + PG++ V EG+ ++L C+V
Sbjct: 2695 VCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQA 2754
Query: 1114 PAQLTYTWYQDGQQRLDAHS-----IPLPNVTVRDATSYRCGV----GP----------- 1153
AQ+ TW++ G H + L +V+ D+ Y C V GP
Sbjct: 2755 HAQV--TWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEA 2812
Query: 1154 ----------PGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQL 1203
PG AP PI ++ P + R+ GQ + C V + AQ+
Sbjct: 2813 SGSSAVHVPAPGGAP----PIRIE----PSSSRVA------EGQTLDLKCVVPGQAHAQV 2858
Query: 1204 ALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE--GV 1261
G L + P L L P D G YSC G S+ + +E
Sbjct: 2859 TWHKRGGNLPARHQVHGP---LLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSP 2915
Query: 1262 RVILAPEAAVP-----------EGAPITVTCADPA-AHAPTLYTWYHNGRWL---QEGPA 1306
I AP A P EG + + C P AHA TWY G L +
Sbjct: 2916 GPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQV--TWYKRGGSLPARHQTHG 2973
Query: 1307 ASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR-DSRARSMAVI 1365
+ L + + A +G Y C+A A G + A+ V P + SS+R S S+
Sbjct: 2974 SQLRLHLVSPADSGEYVCRA--ASGPGPEQEASFTVTVPPSEG--SSYRLRSPVISIDPP 3029
Query: 1366 QCTVDSEPPAEL-ALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV-PAGDDTY 1423
TV A L HDG + +V ++ N + + P+ TY
Sbjct: 3030 SSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTY 3089
Query: 1424 VCTAQNLLGSISTIGRLQVEG---ARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFA 1480
C A N G ++ L V G V+ E + V G A+ L C G P S+
Sbjct: 3090 RCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEP----RSSAR 3145
Query: 1481 WFWNDRRLHAEPV-------------PTLAFTHVARAQAGMYHCLAELPTGAAASAPVML 1527
W R+ + P L + + AG Y CLA+ G A
Sbjct: 3146 W----TRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQK----- 3196
Query: 1528 RVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHI 1587
+ V V+ G + + A LT+ G G+PA P I
Sbjct: 3197 ---------QVEVIVDTGAMAPGAPQVQAEE---AELTVEAGHTATLRCSATGSPA-PTI 3243
Query: 1588 H--VLASP----NALRVD---IEALRPSDQGEYICSASNVLGSASTSTYFGVRA 1632
H L SP + L D I + D G+YIC+A++ G A + V +
Sbjct: 3244 HWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVES 3297
Score = 184 bits (466), Expect = 8e-46
Identities = 374/1696 (22%), Positives = 593/1696 (34%), Gaps = 304/1696 (17%)
Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEE----PRVPTIASPVEL----- 150
L L + P DSG Y R E + + + +++ T VP P+ +
Sbjct: 2102 LRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSS 2161
Query: 151 --LEGTEVDFNCSTPYVCLQEQVRLQWQ---GQDPARSVTFNSQKFEPTGVGHLETLHMA 205
EG +D NC P Q ++ W G PAR T G L LH
Sbjct: 2162 HVAEGQTLDLNCVVPG---QAHAQVTWHKRGGSLPARHQTH----------GSLLRLHQV 2208
Query: 206 MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVK-ILLSPSGRNILPGELVTLTCQV 264
+ + A + ++ P + + + S + G+ + L+C V
Sbjct: 2209 TPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVV 2268
Query: 265 NSSYPAVSSIKWLKDG----VRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPIS 320
A + + W K G R Q + L++ QA+ +DAG Y C+A NG+ + ++ ++
Sbjct: 2269 AGQ--AHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVT 2326
Query: 321 ----LHIFMAEVQVSP------AGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLL--- 367
++ P + + E QT+ L C P + S + +W+K L
Sbjct: 2327 GTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQ--SHAQVTWHKRGGSLPVR 2384
Query: 368 EDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL--TPVL----TAFL 421
H LRL+ A+ AD+G Y C V GS SV+V P P L T +
Sbjct: 2385 HQTHGSLLRLYQASPADSGEYVCRVL---GSSVPLEASVLVTIEPAGSVPALGVTPTVRI 2441
Query: 422 ETQAGLVGI-----LHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRL 476
E+ + V L+C V + A + G L + H S RL
Sbjct: 2442 ESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPAR-----HQVHGS--------RL 2488
Query: 477 EIRDLEETDSGEYKCSATNSLGNATSTL---------DFHANAARLLI---SPAAEVVEG 524
+ + DSGEY C S G +++ H+ + S +A + G
Sbjct: 2489 RLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANG 2548
Query: 525 QAVTLSCRSGLSPTPDARFSWYLNGALL---HEGPGSSLLLPAASSTDAGSYHCRARDGH 581
+ L+C S P +WY G L H+ GS L +P + D+G Y C +G
Sbjct: 2549 HTLDLNCLVA-SQAPHT-ITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGA 2606
Query: 582 SASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGA--GRRGLLLCRVDSDPPARLQLLHK 639
+ S + P+ + + ++++ G+ L C V P A + +
Sbjct: 2607 GSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKR 2666
Query: 640 DRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNAS 699
GG P T +L +H + + G Y+C A+N +
Sbjct: 2667 -----------------GGSLPSRHQTHGSHL---RLHQMSVADSGEYVCRANNNIDALE 2706
Query: 700 TSATFN-----------GQATVLAIAPSHT-LQEGTEANLTCNVSREAAGSPANFSWFRN 747
S + G + + I S + + EG +L C V +A A +W +
Sbjct: 2707 ASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAH---AQVTWHKR 2763
Query: 748 GVLWA---QGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSAL 804
G Q + L V+ D+ Y CR++ +G P+ SVL + SA+
Sbjct: 2764 GGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSG-----PLEASVLVTIEASGSSAV 2818
Query: 805 LDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSH---GRFQAKAEANSLKL 861
G S +A + ++ QV H G A+ + + L
Sbjct: 2819 HVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLL 2878
Query: 862 EVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQ-------------E 908
+ ++ DSG Y C+ T G+ S+ + + P+P L E
Sbjct: 2879 RLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTE 2938
Query: 909 GQAVVLSC----QVHTGVPEGTSYRWYRDGQPL---QESTSATLRFAAITLTQAGAYHCQ 961
GQ + L+C Q H V WY+ G L ++ + LR ++ +G Y C+
Sbjct: 2939 GQTLDLNCVVPGQAHAQVT------WYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCR 2992
Query: 962 AQA-PG---SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRL 1017
A + PG A+ ++ P S SY R ++ + V A +
Sbjct: 2993 AASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSST---------VQQGQDASFKC 3043
Query: 1018 LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQAS 1077
L D +L+ + +H++ PN + I G + G Y C ASN G A
Sbjct: 3044 LIHDGAAPISLEWKTRNQELEDNVHIS--PNGSIITIVGTRPSNHGTYRCVASNAYGVAQ 3101
Query: 1078 ASADFDAQAV-NVQVWPGATV--REGQLVNLTCLV---------WT---THPAQLTYTWY 1122
+ + V V P V + G+ V L C+ WT + PA+L Y
Sbjct: 3102 SVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTY 3161
Query: 1123 QDGQQRLDAHSI-PLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYL 1180
+D+H++ + + DA +Y C G A + I AP ++
Sbjct: 3162 G----LMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV--- 3214
Query: 1181 LESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQP------- 1233
Q TV++ H L S+T + P +LR P P
Sbjct: 3215 ------QAEEAELTVEA--------GHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEG 3260
Query: 1234 ----------RDEGFYSCSARSPLGQANTSLELRLEG--VRVILAPEAAVPEGAPITVTC 1281
+D G Y C+A SP G A ++ L +E + A+V G + + C
Sbjct: 3261 DTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQC 3320
Query: 1282 ADPAAHA--PTLYTWYHNGRWLQEGPAASLSFLVATRA---HAGAYSCQAQD-------- 1328
AH P + W G L A L RA +G Y C+ +
Sbjct: 3321 L---AHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAF 3377
Query: 1329 ----AQGTRSSRPA-ALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDG 1383
QG S PA ++ P V + C V S+ +L +G
Sbjct: 3378 AQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEG 3437
Query: 1384 KVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVE 1443
L HS+ G LR+Q D TY+C A G +L ++
Sbjct: 3438 GQLPPG---HSVQDGV---------LRIQNLDQSC-QGTYICQAHGPWGKAQASAQLVIQ 3484
Query: 1444 GARVVA----EPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPV-----P 1494
V V G A+ C LG P P W+ H P
Sbjct: 3485 ALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVT------WSKVGGHLRPGIVQSGG 3538
Query: 1495 TLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDC 1554
+ HV A AG Y C A G S ++L P + V V G + C
Sbjct: 3539 VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVP--AGSAAVFPC 3596
Query: 1555 RVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICS 1614
P ++ S+L S P E ++ +L S +RP D G Y+C+
Sbjct: 3597 IASGYPTPDISW---SKLDGSLPPDSR-LENNMLMLPS----------VRPQDAGTYVCT 3642
Query: 1615 ASNVLGSASTSTYFGV 1630
A+N G + V
Sbjct: 3643 ATNRQGKVKAFAHLQV 3658
Score = 181 bits (459), Expect = 5e-45
Identities = 377/1594 (23%), Positives = 584/1594 (36%), Gaps = 327/1594 (20%)
Query: 226 AQSEIHLQVKYA----PKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGV 281
AQ+ I + V A P VKI S ++ G+ + L C V S A + + W + G
Sbjct: 2034 AQARIQVVVLSASDASPPPVKI--ESSSPSVTEGQTLDLNCVVAGS--AHAQVTWYRRGG 2089
Query: 282 RLQTKTGV----LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGP-- 335
L T V L LPQ + +D+G Y C+ ENG G P I ++ + + +GP
Sbjct: 2090 SLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSG-----PKEASITVSVLHGTHSGPSY 2144
Query: 336 ------------------ILENQTVTLVCNTPNEAPSDLRYSWYKNHVLL---EDAHSHT 374
+ E QT+ L C P +A + + +W+K L H
Sbjct: 2145 TPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQV--TWHKRGGSLPARHQTHGSL 2202
Query: 375 LRLHLATRADTGFYFCEVQNVHGS-ERSGPVSVVVNHPPLTPVLTAFLETQAGLVG---- 429
LRLH T AD+G Y C V G E S V++ + P P+ +E+ + V
Sbjct: 2203 LRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIP-GPIPPVRIESSSSTVAEGQT 2261
Query: 430 -ILHCSVVSEPLATLV-LSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
L C V + A + GG + A H R S RL I D+G
Sbjct: 2262 LDLSCVVAGQAHAQVTWYKRGGSLPAR------HQVRGS--------RLYIFQASPADAG 2307
Query: 488 EYKCSATNSL---------GNATSTLDFHANAAR-LLISP-AAEVVEGQAVTLSCRSGLS 536
+Y C A+N + G + L + A + + + I P +++V EGQ + L+C +
Sbjct: 2308 QYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNC--VVP 2365
Query: 537 PTPDARFSWYLNGALL---HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLT 593
A+ +W+ G L H+ GS L L AS D+G Y CR +S P +VL
Sbjct: 2366 GQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVL---GSSVPLEASVLV 2422
Query: 594 VLYPPRQ-----PTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLP 648
+ P T T R++ ++ G+ L C V A++ HK
Sbjct: 2423 TIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQV-TWHKR-------- 2473
Query: 649 SGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQA 708
GG P L +++ + G Y+C + G S Q
Sbjct: 2474 --------GGSLPARHQVHGSRLRLLQV---TPADSGEYVCRVVGSSGTQEASVLVTIQQ 2522
Query: 709 ------------TVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWF-RNGVLWAQGP 755
V + S +L G +L C V+ +A P +W+ R G L ++
Sbjct: 2523 RLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQA---PHTITWYKRGGSLPSRHQ 2579
Query: 756 L--ETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSV----------LYPPDRPKLSA 803
+ + + V D+ Y C + AG++ T +++++ + PP R + S+
Sbjct: 2580 IVGSRLRIPQVTPADSGEYVCHVSNGAGSR-ETSLIVTIQGSGSSHVPSVSPPIRIE-SS 2637
Query: 804 LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
+ +G C V +P A++ + G +PS + + + L +
Sbjct: 2638 SPTVVEGQTLDLNCVVARQPQAIITWY--------KRGGSLPS------RHQTHGSHLRL 2683
Query: 864 RELGLGDSGSYRCEATNVLGSSNTSLFFQVR---------GAWVQV---SPSPELQEGQA 911
++ + DSG Y C A N + + S+ V G+ + + S S + EG+
Sbjct: 2684 HQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGET 2743
Query: 912 VVLSC----QVHTGVPEGTSYRWYRDGQPL---QESTSATLRFAAITLTQAGAYHCQAQ- 963
+ L+C Q H V W++ G L ++ + LR ++ +G Y C+
Sbjct: 2744 LDLNCVVPGQAHAQV------TWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMG 2797
Query: 964 APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRL 1023
+ G S+ I S A HV P G R++ P+ R+ G L
Sbjct: 2798 SSGPLEASVLVTIEASGSSAV-HV---------PAPGGAPPIRIE---PSSSRVAEGQTL 2844
Query: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLE-------DEGVYICEASNTLGQA 1076
+ V G + H R ++HG +L D G Y C+ + + G
Sbjct: 2845 DLKCV--VPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTL 2902
Query: 1077 SAS--------------ADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWY 1122
AS A AQ + ++ + V EGQ ++L C+V AQ+ TWY
Sbjct: 2903 EASVLVTIEPSSPGPIPAPGLAQPIYIEA-SSSHVTEGQTLDLNCVVPGQAHAQV--TWY 2959
Query: 1123 QDG-----QQRLDAHSIPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLR 1176
+ G + + + L V+ D+ Y C PG S +T+ P +
Sbjct: 2960 KRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTV-----PPSEG 3014
Query: 1177 LTYLLES------------HGGQLALVLCTV-DSRPPAQLALSHAGRLLASSTAASVPNT 1223
+Y L S GQ A C + D P L + L + S PN
Sbjct: 3015 SSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHIS-PNG 3073
Query: 1224 LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG---VRVILAPEAAVPEGAPITVT 1280
+ + G +P + G Y C A + G A + + L + G V V+ V G +T+
Sbjct: 3074 SIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLE 3133
Query: 1281 CADPAAHAPTLYTWYHNGRW--LQEGPA-------------ASLSFLVATRAHAGAYSCQ 1325
C +A P + RW + PA A L A + AG Y C
Sbjct: 3134 CV--SAGEPR-----SSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCL 3186
Query: 1326 AQDAQGTRSSRPAAL-----QVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALS 1380
AQ+A GT + + APQ + A A ++C+ P +
Sbjct: 3187 AQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTI--- 3243
Query: 1381 HDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRL 1440
H K+ + H L T + R+ QD Y+C A + G L
Sbjct: 3244 HWSKLRSPLPWQHRLEGDTLIIP------RVAQQD----SGQYICNATSPAGHAEATIIL 3293
Query: 1441 QVEG---ARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLA 1497
VE A V E V G + L C G P P+ TF W L
Sbjct: 3294 HVESPPYATTVPEHA-SVQAGETVQLQCLAHGTP-PL---TFQWSRVGSSLPGRATARNE 3348
Query: 1498 FTHVARA---QAGMYHCLAELPTGAAASAPVMLRVLYPP-----------KTPTMMVFVE 1543
H RA +G Y C G +A A L V PP TPT+ V +
Sbjct: 3349 LLHFERAAPEDSGRYRCRVTNKVG-SAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQ 3407
Query: 1544 PEG---GLRGILDCRVDSEPLASLT-LHLGSRLVASSQPQGAPAEPHIHVLASPNALRVD 1599
E G C V S+ L G +L P G + + +
Sbjct: 3408 LETKSIGASVEFHCAVPSDRGTQLRWFKEGGQL-----PPGHSVQDGV----------LR 3452
Query: 1600 IEALRPSDQGEYICSASNVLGSASTSTYFGVRAL 1633
I+ L S QG YIC A G A S ++AL
Sbjct: 3453 IQNLDQSCQGTYICQAHGPWGKAQASAQLVIQAL 3486
Score = 156 bits (394), Expect = 2e-37
Identities = 347/1569 (22%), Positives = 559/1569 (35%), Gaps = 307/1569 (19%)
Query: 243 ILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDG----VRLQTKTGVLHLPQAAWS 298
I + PS ++ G+ + L C V A + + W K G R QT +L L Q +
Sbjct: 2154 IRIEPSSSHVAEGQTLDLNCVVPGQ--AHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPA 2211
Query: 299 DAGVYTCQAENGVGSL-VSPPISLHIFMAEVQVSP------AGPILENQTVTLVCNTPNE 351
D+G Y C G L S +++ + + P + + E QT+ L C +
Sbjct: 2212 DSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQ 2271
Query: 352 APSDLRYSWYKNHVLLEDAHS---HTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVV 408
A + + +WYK L H L + A+ AD G Y C N G E S V+V
Sbjct: 2272 AHAQV--TWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASN--GMEASITVTV-- 2325
Query: 409 NHPPLTPVLTAFLETQAGLVGILHCSVVSEPLA-------TLVLSHGGHILASTSGDSDH 461
T A L AG + S +A V+ H +
Sbjct: 2326 -----TGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGS 2380
Query: 462 SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSL----GNATSTLDFHANAARLLISP 517
P T G L + DSGEY C S + T++ + L ++P
Sbjct: 2381 LPVRHQTHGS---LLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTP 2437
Query: 518 -------AAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALL---HEGPGSSLLLPAASS 567
+++V EGQ + L+C ++ A+ +W+ G L H+ GS L L +
Sbjct: 2438 TVRIESSSSQVAEGQTLDLNCL--VAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTP 2495
Query: 568 TDAGSYHCRARDGHSASGPSSPAVLTVLYP------PRQPTFTTRLDLDAAGAGAGRRGL 621
D+G Y CR +SG +VL + + + R++ +A G
Sbjct: 2496 ADSGEYVCRVV---GSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLD 2552
Query: 622 LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLL 681
L C V S P + + SLPS R ++ + R+ I
Sbjct: 2553 LNCLVASQAPHTITWYKR----GGSLPS------------RHQIVGS----RLRIPQVTP 2592
Query: 682 EEEGLYLCEASNALGNASTSATF----NGQATVLAIAP-------SHTLQEGTEANLTCN 730
+ G Y+C SN G+ TS +G + V +++P S T+ EG +L C
Sbjct: 2593 ADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCV 2652
Query: 731 VSREAAGSPANFSWFRNGVLWAQGPLET--------VTLLPVARTDAALYACRILTEAGA 782
V+R+ A +W++ G G L + + L ++ D+ Y CR A
Sbjct: 2653 VARQPQ---AIITWYKRG-----GSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDA 2704
Query: 783 QLSTPVLLSVLYPPDRPK-----LSALLDMGQGHMALFICTVDSRPLALLALFHGE-HLL 836
L +++SV P + ++ H+A + L L + G+ H
Sbjct: 2705 -LEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVA------EGETLDLNCVVPGQAHAQ 2757
Query: 837 AT--SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894
T G +PSH + + +L + + DSG Y C G S+ +
Sbjct: 2758 VTWHKRGGSLPSHHQTRGS------RLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIE 2811
Query: 895 GAW--------------VQVSPSPE-LQEGQAVVLSC----QVHTGVPEGTSYRWYRDGQ 935
+ +++ PS + EGQ + L C Q H V W++ G
Sbjct: 2812 ASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVT------WHKRGG 2865
Query: 936 PL---QESTSATLRFAAITLTQAGAYHCQA-----------------QAPGSATT-SLAA 974
L + LR ++ +G Y CQ +PG LA
Sbjct: 2866 NLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQ 2925
Query: 975 PISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034
PI + S + HVT +D L C V AQ+ + + Q
Sbjct: 2926 PIYIEASSS--HVTEGQTLD--------LNCVVPGQAHAQVTWYKRGGSLPARHQ----T 2971
Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQA-----------SASADFD 1083
GS RLH+ V+P D G Y+C A++ G S + +
Sbjct: 2972 HGSQLRLHL-VSP------------ADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYR 3018
Query: 1084 AQAVNVQVWP-GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLD-AHSIPLPNVTV 1141
++ + + P +TV++GQ + CL+ A ++ W Q+ D H P ++
Sbjct: 3019 LRSPVISIDPPSSTVQQGQDASFKCLIHDG-AAPISLEWKTRNQELEDNVHISPNGSIIT 3077
Query: 1142 RDAT------SYRC------GVGPPGRAPRLSRPITLDVL-----YAPRNLRLTYLLESH 1184
T +YRC GV + P T+ VL + +T S
Sbjct: 3078 IVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSA 3137
Query: 1185 GGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSAR 1244
G + T S PA+L G L S A L++ +P D G Y C A+
Sbjct: 3138 GEPRSSARWTRISSTPAKLEQRTYG--LMDSHAV-------LQISSAKPSDAGTYVCLAQ 3188
Query: 1245 SPLGQANTSLELRLE------GVRVILAPEA--AVPEGAPITVTCADPAAHAPTLYTWYH 1296
+ LG A +E+ ++ G + A EA V G T+ C+ + APT++ W
Sbjct: 3189 NALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIH-WSK 3247
Query: 1297 NGR---WLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSS 1353
W +L + +G Y C A G + L V P +
Sbjct: 3248 LRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAG-HAEATIILHVESPPYATTVPE 3306
Query: 1354 FRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQV 1413
+A +QC PP S G L + ARN L
Sbjct: 3307 HASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRA-------------TARNELLHFE 3353
Query: 1414 QDVPAGDDTYVCTAQNLLGSISTIGRLQVEGA---------------RVVAEPGLDVPE- 1457
+ P Y C N +GS +L V+G V P L+
Sbjct: 3354 RAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSI 3413
Query: 1458 GAALNLSCRLLGGPGPVGNSTFAWFWNDRRL---HAEPVPTLAFTHVARAQAGMYHCLAE 1514
GA++ C + G + WF +L H+ L ++ ++ G Y C A
Sbjct: 3414 GASVEFHCAVPSDRG----TQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAH 3469
Query: 1515 LPTGAA-ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLV 1573
P G A ASA ++++ L P++++ +R + V + L LG
Sbjct: 3470 GPWGKAQASAQLVIQAL-----PSVLI------NIRTSVQTVVVGHAVEFECLALGD--- 3515
Query: 1574 ASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRAL 1633
Q + H+ + V I + +D G+Y C+A+N G+ + V+AL
Sbjct: 3516 PKPQVTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQAL 3575
Query: 1634 HRLHQFQQL 1642
++ Q++
Sbjct: 3576 PQISMPQEV 3584
Score = 117 bits (292), Expect = 1e-25
Identities = 221/958 (23%), Positives = 352/958 (36%), Gaps = 170/958 (17%)
Query: 93 PEH---RVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTL-------VTVTEEPRVP 142
P H R L L + P DSG Y R S + V T+ V V P
Sbjct: 2768 PSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAP 2827
Query: 143 TIA---SPVELLEGTEVDFNCSTPYVCLQEQVRLQWQ---GQDPARSVTFNSQKFEPTGV 196
I S + EG +D C P Q ++ W G PAR
Sbjct: 2828 PIRIEPSSSRVAEGQTLDLKCVVPG---QAHAQVTWHKRGGNLPARHQVH---------- 2874
Query: 197 GHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGV--------KILLSPS 248
G L L+ +S D G CQ++ ++ ++ + + ++ + G I + S
Sbjct: 2875 GPLLRLNQ-VSPADSGEY-SCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEAS 2932
Query: 249 GRNILPGELVTLTCQVNSSYPAVSSIKWLKDG----VRLQTKTGVLHLPQAAWSDAGVYT 304
++ G+ + L C V A + + W K G R QT L L + +D+G Y
Sbjct: 2933 SSHVTEGQTLDLNCVVPGQ--AHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYV 2990
Query: 305 CQAENGVG-------SLVSPPISLHIFMAEVQV----SPAGPILENQTVTLVCNTPNEAP 353
C+A +G G ++ PP + V P+ + + Q + C ++
Sbjct: 2991 CRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLI-HDGA 3049
Query: 354 SDLRYSWYKNHVLLED----AHSHTLRLHLATR-ADTGFYFCEVQNVHGSERSGPVSVVV 408
+ + W + LED + + ++ + TR ++ G Y C N +G +S V++ V
Sbjct: 3050 APISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQS-VVNLSV 3108
Query: 409 NHPPLTPVLTAF-LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSG 467
+ PP VL + + G L C EP ++ + ++ST + R G
Sbjct: 3109 HGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTR----ISSTPAKLEQ--RTYG 3162
Query: 468 TSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE---- 523
+++ L+I + +D+G Y C A N+LG A ++ + + +P A V+
Sbjct: 3163 LMDSHAV-LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAM--APGAPQVQAEEA 3219
Query: 524 ------GQAVTLSCRSGLSPTPDARFSWYLNGAL--LHEGPGSSLLLPAASSTDAGSYHC 575
G TL C + SP P +S L L H G +L++P + D+G Y C
Sbjct: 3220 ELTVEAGHTATLRCSATGSPAPTIHWS-KLRSPLPWQHRLEGDTLIIPRVAQQDSGQYIC 3278
Query: 576 RARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635
+A+ P+ A T++ P + T + + A AG L C PP Q
Sbjct: 3279 ------NATSPAGHAEATIILHVESPPYATTVP-EHASVQAGETVQLQCLAHGTPPLTFQ 3331
Query: 636 LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695
V +SLP + T LL E P E+ G Y C +N +
Sbjct: 3332 WSR----VGSSLPG--------------RATARNELLHFERAAP--EDSGRYRCRVTNKV 3371
Query: 696 GNA----------------STSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSP 739
G+A +TS TV T G C V +
Sbjct: 3372 GSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRG--- 3428
Query: 740 ANFSWFRNGVLWAQGPLETVTLLPVARTDAAL---YACRI-----LTEAGAQLSTPVLLS 791
WF+ G G +L + D + Y C+ +A AQL L S
Sbjct: 3429 TQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPS 3488
Query: 792 VLYPPDRPKLSALLDMGQGHMALFICTV--DSRPLALLALFHGEHLLATSLGPQVPSHGR 849
VL + ++ GH F C D +P + G L P + G
Sbjct: 3489 VLINIRTSVQTVVV----GHAVEFECLALGDPKPQVTWSKVGGH------LRPGIVQSGG 3538
Query: 850 FQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQ-- 907
+ + + L D+G YRC ATN G++ + + V+ A Q+S E++
Sbjct: 3539 V----------VRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQ-ALPQISMPQEVRVP 3587
Query: 908 EGQAVVLSCQVHTGVPEGTSYRWYR-DGQ--PLQESTSATLRFAAITLTQAGAYHCQA 962
G A V C + +G P W + DG P + L ++ AG Y C A
Sbjct: 3588 AGSAAVFPC-IASGYPT-PDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTA 3643
Score = 33.5 bits (75), Expect = 1.8
Identities = 15/40 (37%), Positives = 21/40 (52%)
Query: 844 VPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLG 883
+PSH R +E L +R++ D G+Y CEA N G
Sbjct: 447 IPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
Score = 32.3 bits (72), Expect = 4.1
Identities = 16/36 (44%), Positives = 21/36 (58%)
Query: 463 PRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG 498
PR + TS L IRD++E+D G Y C A N+ G
Sbjct: 451 PRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
>gi|157168355 CD22 molecule [Homo sapiens]
Length = 847
Score = 178 bits (452), Expect = 4e-44
Identities = 174/659 (26%), Positives = 286/659 (43%), Gaps = 73/659 (11%)
Query: 5 PKLLLLASFFPA--GQASWGVSSPQDVQGVKGSCLLIPCIF-SFPADVEVPDGITAIWYY 61
P LLLL + A + W P+ + +G+C+ IPC + + D+E + I ++
Sbjct: 6 PWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLE-----SFILFH 60
Query: 62 DYSGQRQVVSHSADPKLVEARFRG-------RTEFMGNPEHRVCNLLLKDLQPEDSGSYN 114
+ + S +L E+ G R +F+G+ +++ C L + + DSG
Sbjct: 61 NPEYNKNT-SKFDGTRLYESTKDGKVPSEQKRVQFLGD-KNKNCTLSIHPVHLNDSGQLG 118
Query: 115 FRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQ 174
R E S+ +W ++ + V+E P P I P E+ E EV C + C ++LQ
Sbjct: 119 LRME-SKTEKW--MERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQ 175
Query: 175 WQGQD-PARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHR--AQSEIH 231
W + P R S V L + W HG+I+ CQL A+ + + +
Sbjct: 176 WLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQ 235
Query: 232 LQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTK-TGVL 290
L VK+ PK ++I ++PS + G+ VT+TC+V+SS P +++ WLKDG L+ + T L
Sbjct: 236 LNVKHTPK-LEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTL 294
Query: 291 HLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPA--------GPILENQTV 342
+L + +G Y CQ N VG P S +F+ +VQ +P P +E V
Sbjct: 295 NLREVTKDQSGKYCCQVSNDVG----PGRSEEVFL-QVQYAPEPSTVQILHSPAVEGSQV 349
Query: 343 TLVC-NTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERS 401
+C + N P++ Y+WY N ++ + + G Y C +N+ G+ +
Sbjct: 350 EFLCMSLANPLPTN--YTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQR 407
Query: 402 GP-VSVVVNHPP--LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGD 458
GP + V +PP +T V+ + + G L C+ S + H
Sbjct: 408 GPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPH-------- 459
Query: 459 SDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR-----L 513
P+ L+I+++ D+ C+A NS + S + + A
Sbjct: 460 -------GAWEEPSLGVLKIQNV-GWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVR 511
Query: 514 LISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSY 573
I P +E+ G +V+L C S + +F W NG LL G S L + S DAGSY
Sbjct: 512 KIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLL--GKESQLNFDSISPEDAGSY 569
Query: 574 HCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAG-AGAGRRGLLLCRVDSDPP 631
C + + S L VLY PR+ R+ + G+ L C D++PP
Sbjct: 570 SCWVNNSIGQTA-SKAWTLEVLYAPRR----LRVSMSPGDQVMEGKSATLTCESDANPP 623
Score = 102 bits (254), Expect = 3e-21
Identities = 128/516 (24%), Positives = 204/516 (39%), Gaps = 90/516 (17%)
Query: 711 LAIAPSHTL-QEGTEANLTCNVSREAAGSP--ANFSWFRNGVLWAQGPLETVTLLPVART 767
+ + PS + +EG +TC VS + +P SW ++G + T+ L V +
Sbjct: 246 IKVTPSDAIVREGDSVTMTCEVS---SSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKD 302
Query: 768 DAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMG-QGHMALFICTVDSRPLAL 826
+ Y C++ + G S V L V Y P+ + L +G F+C + PL
Sbjct: 303 QSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPT 362
Query: 827 LALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN 886
++ + Q + E K+ + ++ +G+Y C A N+LG+
Sbjct: 363 NYTWY-------------HNGKEMQGRTEE---KVHIPKILPWHAGTYSCVAENILGTGQ 406
Query: 887 TSLFFQVRGAWVQVSPSPE-----------LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQ 935
GA + V P+ ++EG V LSC ++ P T Y W G
Sbjct: 407 RG-----PGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHG- 460
Query: 936 PLQESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHV---TLTTL 992
+E + L+ + A A ++ S A+P++L+V YAPR V + L
Sbjct: 461 AWEEPSLGVLKIQNVGWDNTTI----ACAACNSWCSWASPVALNVQYAPRDVRVRKIKPL 516
Query: 993 MDTGPGRLGLLLCRVDSDPPAQLRLL--HGDRLVASTLQGVGGPEGSSPRLHVAVAPNTL 1050
+ G L C S P +++ RL+ Q
Sbjct: 517 SEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ--------------------- 555
Query: 1051 RLEIHGAMLEDEGVYICEASNTLGQASASA-----DFDAQAVNVQVWPGATVREGQLVNL 1105
L ED G Y C +N++GQ ++ A + + + V + PG V EG+ L
Sbjct: 556 -LNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATL 614
Query: 1106 TCLVWTTHPAQLTYTWYQDGQQRLDAHS--IPLPNVTVRDATSYRC----GVGPPGRAPR 1159
TC +P YTW+ Q L HS + L V V+ + +Y C VG GR+P
Sbjct: 615 TC-ESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVG-KGRSP- 671
Query: 1160 LSRPITLDVLYAPRNL--RLTYLLESHGGQLALVLC 1193
LS TL V Y+P + R+ L S L L +C
Sbjct: 672 LS---TLTVYYSPETIGRRVAVGLGSCLAILILAIC 704
Score = 95.9 bits (237), Expect = 3e-19
Identities = 123/480 (25%), Positives = 198/480 (41%), Gaps = 71/480 (14%)
Query: 1087 VNVQVWPG-ATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQ--QRLDAHSIPLPNVTVRD 1143
+ ++V P A VREG V +TC V +++P T +W +DG ++ + ++ L VT
Sbjct: 244 LEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQ 303
Query: 1144 ATSYRCGVG---PPGRAPRLSRPITLDVLYAPR--NLRLTYLLESHGGQLALVLCTVDSR 1198
+ Y C V PGR S + L V YAP +++ + G Q+ + ++ +
Sbjct: 304 SGKYCCQVSNDVGPGR----SEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANP 359
Query: 1199 PPAQLALSHAGRLLASSTAASV--PNTLRLELRGPQPRDEGFYSCSARSPL--GQANTSL 1254
P H G+ + T V P L P G YSC A + L GQ
Sbjct: 360 LPTNYTWYHNGKEMQGRTEEKVHIPKIL--------PWHAGTYSCVAENILGTGQRGPGA 411
Query: 1255 ELRLE----GVRVILAPEAAVPEGAPITVTCADPAAH-APTLYTWYHNGRWLQEGPAASL 1309
EL ++ V ++ + EG +T++C +++ + T Y W +G W E P+ +
Sbjct: 412 ELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAW--EEPSLGV 469
Query: 1310 SFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR---DSRARSMAVIQ 1366
+ +C A ++ + +S P AL V YAP+D + + + + + +Q
Sbjct: 470 LKIQNVGWDNTTIACAACNSWCSWAS-PVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQ 528
Query: 1367 CTVDSEPPAELAL--SHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV-PAGDDTY 1423
C S P E+ +G++L S +L + P +Y
Sbjct: 529 CDFSSSHPKEVQFFWEKNGRLLGKES-------------------QLNFDSISPEDAGSY 569
Query: 1424 VCTAQNLLG-SISTIGRLQVEGA----RVVAEPGLDVPEGAALNLSCRLLGGPGPVGNST 1478
C N +G + S L+V A RV PG V EG + L+C P PV S
Sbjct: 570 SCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANP-PV--SH 626
Query: 1479 FAWF-WNDRRL--HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKT 1535
+ WF WN++ L H++ L V +G Y C G S L V Y P+T
Sbjct: 627 YTWFDWNNQSLPYHSQ---KLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPET 683
Score = 93.2 bits (230), Expect = 2e-18
Identities = 114/420 (27%), Positives = 180/420 (42%), Gaps = 53/420 (12%)
Query: 201 TLHMAMSWQDHGRILRCQLS--VANHRAQSEIHLQVKYAPKG--VKILLSPSGRNILPGE 256
TL++ +D CQ+S V R++ E+ LQV+YAP+ V+IL SP+ + G
Sbjct: 293 TLNLREVTKDQSGKYCCQVSNDVGPGRSE-EVFLQVQYAPEPSTVQILHSPA----VEGS 347
Query: 257 LVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV-LHLPQAAWSDAGVYTCQAENGVGS-L 314
V C ++ + P ++ W +G +Q +T +H+P+ AG Y+C AEN +G+
Sbjct: 348 QVEFLC-MSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQ 406
Query: 315 VSPPISLHIFMAEVQVSPA----GPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDA 370
P L + +V+ PI E TVTL CN + PS RY W K H E+
Sbjct: 407 RGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEW-KPHGAWEEP 465
Query: 371 HSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL---TPVLTAFLETQAGL 427
L++ +T C N S S PV++ V + P + E +G
Sbjct: 466 SLGVLKIQNVGWDNTTIA-CAACNSWCSWAS-PVALNVQYAPRDVRVRKIKPLSEIHSGN 523
Query: 428 VGILHCSVVSEPLATLVL--SHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETD 485
L C S + G +L S +L + D
Sbjct: 524 SVSLQCDFSSSHPKEVQFFWEKNGRLLGKES------------------QLNFDSISPED 565
Query: 486 SGEYKCSATNSLGNATS---TLD--FHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPD 540
+G Y C NS+G S TL+ + R+ +SP +V+EG++ TL+C S +P P
Sbjct: 566 AGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANP-PV 624
Query: 541 ARFSWY--LNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
+ ++W+ N +L + L L +G+Y C+ + G S + LTV Y P
Sbjct: 625 SHYTWFDWNNQSLPYH--SQKLRLEPVKVQHSGAYWCQGTNS-VGKGRSPLSTLTVYYSP 681
Score = 84.3 bits (207), Expect = 9e-16
Identities = 136/593 (22%), Positives = 234/593 (39%), Gaps = 88/593 (14%)
Query: 830 FHGEHLLATSLGPQVPSHG-RFQAKAEAN-SLKLEVRELGLGDSGSY--RCEATNVLGSS 885
F G L ++ +VPS R Q + N + L + + L DSG R E+
Sbjct: 71 FDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWME 130
Query: 886 NTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVH---TGVPEGTSYRWYRDGQPLQE--- 939
L R + PE+QE Q V L+C ++ G P +W +G P+++
Sbjct: 131 RIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYP--IQLQWLLEGVPMRQAAV 188
Query: 940 -STSATLRF----AAITLTQAGAYH-----CQAQ-APGSATTSLAAPISLHVSYAPRHVT 988
STS T++ + + + ++H CQ Q A G ++ + L+V + P+
Sbjct: 189 TSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSN--DTVQLNVKHTPKLEI 246
Query: 989 LTTLMD--TGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVA 1046
T D G + C V S P + S L+ +G+S +
Sbjct: 247 KVTPSDAIVREGDSVTMTCEVSSSNP--------EYTTVSWLK-----DGTSLK-----K 288
Query: 1047 PNTLRLEIHGAMLEDEGVYICEASNTLG-----QASASADFDAQAVNVQVWPGATVREGQ 1101
NT L + + G Y C+ SN +G + + + VQ+ V EG
Sbjct: 289 QNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAV-EGS 347
Query: 1102 LVNLTCLVWTTHPAQLTYTWYQDGQ--QRLDAHSIPLPNVTVRDATSYRC------GVGP 1153
V C+ +P YTWY +G+ Q + +P + A +Y C G G
Sbjct: 348 QVEFLCMS-LANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQ 406
Query: 1154 PGRAPRLSRPITLDVLYAPRNLRLTYLLES----HGGQLALVLCTVDSRPPAQLALSHAG 1209
G LDV Y P+ ++T ++++ G + C +S P+
Sbjct: 407 RGPGAE------LDVQYPPK--KVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKP 458
Query: 1210 RLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE----GVRV-I 1264
+ V L+++ G D +C+A + + + L ++ VRV
Sbjct: 459 HGAWEEPSLGV---LKIQNVG---WDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRK 512
Query: 1265 LAPEAAVPEGAPITVTCADPAAHAPTL-YTWYHNGRWLQEGPAASLSFLVATRAHAGAYS 1323
+ P + + G +++ C ++H + + W NGR L G + L+F + AG+YS
Sbjct: 513 IKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLL--GKESQLNFDSISPEDAGSYS 570
Query: 1324 CQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPP 1374
C ++ G +S+ L+VLYAP+ +S + A + C D+ PP
Sbjct: 571 CWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPP 623
Score = 84.0 bits (206), Expect = 1e-15
Identities = 57/191 (29%), Positives = 87/191 (45%), Gaps = 6/191 (3%)
Query: 228 SEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKT 287
S + L V+YAP+ V++ I G V+L C +SS+P W K+G RL K
Sbjct: 495 SPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNG-RLLGKE 553
Query: 288 GVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA----EVQVSPAGPILENQTVT 343
L+ + DAG Y+C N +G S +L + A V +SP ++E ++ T
Sbjct: 554 SQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSAT 613
Query: 344 LVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGP 403
L C + P Y+W+ + HS LRL +G Y+C+ N G RS
Sbjct: 614 LTCESDANPPVS-HYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPL 672
Query: 404 VSVVVNHPPLT 414
++ V + P T
Sbjct: 673 STLTVYYSPET 683
Score = 68.6 bits (166), Expect = 5e-11
Identities = 115/526 (21%), Positives = 192/526 (36%), Gaps = 85/526 (16%)
Query: 520 EVVEGQAVTLSCRSGLSPTP-DARFSWYLNGALLHEGPGSSLLLPAASS--------TDA 570
E+ E Q VTL+C S + W L G + + +S L S +
Sbjct: 150 EIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQ 209
Query: 571 GSYH-----CRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCR 625
S+H C+ +D + L V + P+ T D A G + C
Sbjct: 210 WSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSD---AIVREGDSVTMTCE 266
Query: 626 VDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685
V S P + + L G K N + + ++ G
Sbjct: 267 VSSSNP--------EYTTVSWLKDGTSL-------------KKQNTFTLNLREVTKDQSG 305
Query: 686 LYLCEASNALGNASTSATF-----NGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740
Y C+ SN +G + F + + + I S + EG++ C A P
Sbjct: 306 KYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAV-EGSQVEFLC--MSLANPLPT 362
Query: 741 NFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAG-AQLSTPVLLSVLYPPDRP 799
N++W+ NG E V + + A Y+C G Q L V YPP +
Sbjct: 363 NYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKK- 421
Query: 800 KLSALLDMGQGHMALFICTVDSRPLALLALFHGEHL-LATSLGPQVPSHGRFQAK----- 853
+ TV P+ + G+ + L+ + PS R++ K
Sbjct: 422 ----------------VTTVIQNPMPIR---EGDTVTLSCNYNSSNPSVTRYEWKPHGAW 462
Query: 854 AEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGA-----WVQVSPSPELQE 908
E + L+++ +G D+ + C A N S + + V+ A ++ P E+
Sbjct: 463 EEPSLGVLKIQNVG-WDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHS 521
Query: 909 GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSA 968
G +V L C + P+ + W ++G+ L + + L F +I+ AG+Y C
Sbjct: 522 GNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ--LNFDSISPEDAGSYSCWVNNSIGQ 579
Query: 969 TTSLAAPISLHVSYAPR--HVTLTTLMDTGPGRLGLLLCRVDSDPP 1012
T S A +L V YAPR V+++ G+ L C D++PP
Sbjct: 580 TASKA--WTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPP 623
Score = 57.4 bits (137), Expect = 1e-07
Identities = 82/383 (21%), Positives = 144/383 (37%), Gaps = 72/383 (18%)
Query: 1268 EAAVPEGAPITVTCADPAAHAP-TLYTWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQA 1326
+A V EG +T+TC +++ T +W +G L++ +L+ T+ +G Y CQ
Sbjct: 252 DAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQV 311
Query: 1327 QDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR-SMAVIQCTVDSEP-PAELALSHDGK 1384
+ G S LQV YAP+ + + S C + P P H+GK
Sbjct: 312 SNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGK 371
Query: 1385 VL--ATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV 1442
+ T VH + +P TY C A+N+LG+ ++
Sbjct: 372 EMQGRTEEKVHI------------------PKILPWHAGTYSCVAENILGTGQRGPGAEL 413
Query: 1443 E------GARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAW----FWNDRRLHAEP 1492
+ V + + + EG + LSC V + + W W + L
Sbjct: 414 DVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSV--TRYEWKPHGAWEEPSLGVLK 471
Query: 1493 VPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGIL 1552
+ + + + A A + + ++PV L V Y P+
Sbjct: 472 IQNVGWDNTTIA-------CAACNSWCSWASPVALNVQYAPR------------------ 506
Query: 1553 DCRVDS-EPLASLTLHLGSRL-----VASSQPQGAPA--EPHIHVLASPNALRVDIEALR 1604
D RV +PL+ +H G+ + +SS P+ E + +L + L D ++
Sbjct: 507 DVRVRKIKPLSE--IHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFD--SIS 562
Query: 1605 PSDQGEYICSASNVLGSASTSTY 1627
P D G Y C +N +G ++ +
Sbjct: 563 PEDAGSYSCWVNNSIGQTASKAW 585
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 170 bits (431), Expect = 1e-41
Identities = 378/1698 (22%), Positives = 598/1698 (35%), Gaps = 312/1698 (18%)
Query: 84 RGRTEFMGNPEHRVCN----LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEP 139
+G + + + EH V N L + P D+G Y ++ +D + V E P
Sbjct: 1206 KGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTC---VATNIAGTDETEITLHVQEPP 1262
Query: 140 RVPTIASPV-----ELLEGTEVDFNC---STPYVCLQEQVRLQWQGQDPARSVTFNSQKF 191
V + P E + ++F C TP + ++W R +T
Sbjct: 1263 TVEDLEPPYNTTFQERVANQRIEFPCPAKGTP------KPTIKWLHN--GRELTGREPGI 1314
Query: 192 EPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRN 251
G L + + D+G + ++ A + + +L+V + P +K + +
Sbjct: 1315 SILEDGTLLVIASVTPY-DNGEYICVAVNEAG-TTERKYNLKV-HVPPVIKDKEQVTNVS 1371
Query: 252 ILPGELVTLTCQVNSSYPAVSSIKWLKDGVR------LQTKTG--VLHLPQAAWSDAGVY 303
+L +L L C+V + + I W KD V+ +QT +L L +A DAG Y
Sbjct: 1372 VLLNQLTNLFCEVEGTPSPI--IMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRY 1429
Query: 304 TCQAENGVGS---------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPS 354
+C+A N G+ LV P I F EV V + N+ V L C
Sbjct: 1430 SCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSV------VLNRDVALECQVKGTPFP 1483
Query: 355 DLRYSWYKNH--VLLEDAHSHTLR----LHL--ATRADTGFYFCEVQNVHGSERSGPVSV 406
D+ W+K+ + L D + L LHL A R D G Y C V N G + + +
Sbjct: 1484 DIH--WFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKD-IKL 1540
Query: 407 VVNHPPLTPV--LTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTS-------G 457
+ PP +T + + L C P+ + G + S+S G
Sbjct: 1541 TIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKG 1600
Query: 458 DSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANA------- 510
H PR + +DS Y C N G A + FH +
Sbjct: 1601 QYLHIPR----------------AQVSDSATYTCHVANVAGTAEKS--FHVDVYVPPMIE 1642
Query: 511 ARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH-------EGPGSSLLLP 563
L +VV ++TL C++ +P+P +W +G + E G L +
Sbjct: 1643 GNLATPLNKQVVIAHSLTLECKAAGNPSPI--LTWLKDGVPVKANDNIRIEAGGKKLEIM 1700
Query: 564 AASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQP----------TFTTRLDLDAAG 613
+A D G Y C A A + VL PP L+LD
Sbjct: 1701 SAQEIDRGQYICVATS--VAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELD--- 1755
Query: 614 AGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLR 673
C V PP + L +++ R N +
Sbjct: 1756 ----------CHVTGSPPPTIMWLKDGQLI----------------DERDGFKILLNGRK 1789
Query: 674 VEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSR 733
+ I + GLY C A+N G+ + V P G +
Sbjct: 1790 LVIAQAQVSNTGLYRCMAANTAGDHKK------EFEVTVHVPPTIKSSGLSERVVVKYKP 1843
Query: 734 EAAGSPAN------FSWFRNG--VLWAQGPLETVT---LLPVART---DAALYACRILTE 779
A AN +W ++ V AQG L+ + +L +A+T DA Y C + T
Sbjct: 1844 VALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTC-VATN 1902
Query: 780 AGAQLSTPVLLSVLYPPDRPKLSALLD--MGQGHMALFICTVDSRPLALLALFHGEHLLA 837
A + + L V PP +L+ + + C P+ ++ + LL+
Sbjct: 1903 AAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLS 1962
Query: 838 TSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAW 897
S + G+ +++ + D+G Y+C A N G+ T LF+ ++
Sbjct: 1963 GSTSMTFLNRGQI----------IDIESAQISDAGIYKCVAINSAGA--TELFYSLQ--- 2007
Query: 898 VQVSPSPELQEGQAVV-------LSCQVHTGVPEGTSYRWYRDGQPLQE--------STS 942
V V+PS V L C+ G+P S W +DG P+ S
Sbjct: 2008 VHVAPSISGSNNMVAVVVNNPVRLECEAR-GIP-APSLTWLKDGSPVSSFSNGLQVLSGG 2065
Query: 943 ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL 1002
L + ++ G Y C A +A I L V P + + +
Sbjct: 2066 RILALTSAQISDTGRYTCVAV---NAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVE 2122
Query: 1003 LLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDE 1062
LLC+ D+ PP L L G P P L +++ N L+I A ++D
Sbjct: 2123 LLCQSDAIPPPTLTWLKD-----------GHPLLKKPGL--SISENRSVLKIEDAQVQDT 2169
Query: 1063 GVYICEASNTLGQASASADFDAQAVNVQVWPGA---------TVREGQLVNLTCLVWTTH 1113
G Y CEA+N G+ + + VN+ V P TV EG L++L C
Sbjct: 2170 GRYTCEATNVAGKTEKNYN-----VNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIP 2224
Query: 1114 PAQLTYTWYQDGQQRLD-----------AHSIPLPNVTVRDATSYRCGVGPPGRAPRLSR 1162
P L W + G L + + DA Y C A +
Sbjct: 2225 PPNLI--WKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVAS--NVAGTAKK 2280
Query: 1163 PITLDVLYAPR----NLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAA 1218
L V P T ++ + G ++L C V PP + G L +
Sbjct: 2281 EYNLQVYIRPTITNSGSHPTEIIVTRGKSISLE-CEVQGIPPPTVTWMKDGHPLIKAKGV 2339
Query: 1219 SVPNTLR-LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL----APE-AAVP 1272
+ + L+L+ D G Y C A + G + +L + I+ +PE +V
Sbjct: 2340 EILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVV 2399
Query: 1273 EGAPITVTCADPAAHAPTLYTWYHNG---------RWLQEGPAASLSFLVATRAHAGAYS 1323
E +++TC P++ TW+ +G R L G L + T AG Y+
Sbjct: 2400 EKNSVSLTCEASGIPLPSI-TWFKDGWPVSLSNSVRILSGG--RMLRLMQTTMEDAGQYT 2456
Query: 1324 CQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSM--AVIQCTVDSEPPAELALSH 1381
C ++A G + L VL P ++ D + + + C V P E+
Sbjct: 2457 CVVRNAAG-EERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHK 2515
Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQ 1441
DG+ L H + SG +Q+ VQ G Y C A + G S L
Sbjct: 2516 DGQPLQEDEA-HHIISGGRFLQITN------VQVPHTG--RYTCLASSPAGHKSRSFSLN 2566
Query: 1442 VEGARVVAEPGLDV-PEGAA--LNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP----VP 1494
V + +A G D PE LN L+ +T WF + L + +P
Sbjct: 2567 VFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILP 2626
Query: 1495 ---TLAFTHVARAQAGMYHCLAELPTGAAAS--------APVMLRV-LYPPKTPTMMVFV 1542
TL + AG Y C+A G P++ + L+ P V +
Sbjct: 2627 GGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKI 2686
Query: 1543 EPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEA 1602
+ L L+C + P ASL+ + G P + HV + N + I+
Sbjct: 2687 KVNNTLT--LECEAYAIPSASLSWY----------KDGQPLKSDDHVNIAANGHTLQIKE 2734
Query: 1603 LRPSDQGEYICSASNVLG 1620
+ SD G Y C ASN+ G
Sbjct: 2735 AQISDTGRYTCVASNIAG 2752
Score = 170 bits (431), Expect = 1e-41
Identities = 355/1578 (22%), Positives = 568/1578 (35%), Gaps = 297/1578 (18%)
Query: 214 ILRCQLS--VANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAV 271
+ RC + +H+ + E+ + V K + S R ++ + V L C N
Sbjct: 1802 LYRCMAANTAGDHKKEFEVTVHVPPTIKSSGL----SERVVVKYKPVALQCIANGI--PN 1855
Query: 272 SSIKWLKD---------GVRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLH 322
SI WLKD +++Q+ VL + + DAG YTC A N G I LH
Sbjct: 1856 PSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGE-TQQHIQLH 1914
Query: 323 IFMAEVQVSPAGPILENQTVTLVCN--------TPNEAPSDLRYSWYKNHVLLEDAHSHT 374
+ + AG +L N+TV LV N N P +WYK++ LL + S T
Sbjct: 1915 VH-EPPSLEDAGKML-NETV-LVSNPVQLECKAAGNPVPV---ITWYKDNRLLSGSTSMT 1968
Query: 375 -------LRLHLATRADTGFYFCEVQNVHG----------------SERSGPVSVVVNHP 411
+ + A +D G Y C N G S + V+VVVN+P
Sbjct: 1969 FLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNP 2028
Query: 412 PLTPVLTAFLETQA------GLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRF 465
LE +A L + S VS L + GG ILA TS
Sbjct: 2029 -------VRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSA-------- 2073
Query: 466 SGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA--AEVVE 523
+ +D+G Y C A N+ G +D ++ V+
Sbjct: 2074 ----------------QISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLI 2117
Query: 524 GQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPG-------SSLLLPAASSTDAGSYHCR 576
QAV L C+S P P +W +G L + PG S L + A D G Y C
Sbjct: 2118 SQAVELLCQSDAIPPP--TLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCE 2175
Query: 577 ARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQL 636
A + +G + ++ P P +L G LLC PP L
Sbjct: 2176 AT---NVAGKTEKNYNVNIWVP--PNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIW 2230
Query: 637 LHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG 696
K V T R+++ L++ I + LY C ASN G
Sbjct: 2231 KKKGSPVLTD------------SMGRVRILSGGRQLQISIAEK--SDAALYSCVASNVAG 2276
Query: 697 NASTSATFNGQATV---LAIAPSHTLQ----EGTEANLTCNVSREAAGSPANFSWFRNG- 748
A +N Q + + + SH + G +L C V P +W ++G
Sbjct: 2277 TAKKE--YNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQ---GIPPPTVTWMKDGH 2331
Query: 749 -VLWAQG-----PLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPD---RP 799
++ A+G + L + +D Y C + AG LSV PP
Sbjct: 2332 PLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAG-MTDKKYDLSVHAPPSIIGNH 2390
Query: 800 KLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSL 859
+ + + + + C PL + F ++ S ++ S GR
Sbjct: 2391 RSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRM--------- 2441
Query: 860 KLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSP---------SPELQEGQ 910
L + + + D+G Y C N G ++ G V V P +++E Q
Sbjct: 2442 -LRLMQTTMEDAGQYTCVVRNAAGEER-----KIFGLSVLVPPHIVGENTLEDVKVKEKQ 2495
Query: 911 AVVLSCQVHTG--VPEGTSYRWYRDGQPLQESTSATL----RFAAITLTQ---AGAYHCQ 961
+V L+C+V TG VPE T W++DGQPLQE + + RF IT Q G Y C
Sbjct: 2496 SVTLTCEV-TGNPVPEIT---WHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCL 2551
Query: 962 AQAP-GSATTSLAAPISLHVSYA-------PRHVTLTTLMDTGPGRLGLLLCRVDSDPPA 1013
A +P G + S + + + + A P VT+ T L+C S PPA
Sbjct: 2552 ASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTS------LVCEAYSYPPA 2605
Query: 1014 QLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTL 1073
+ T G P S+ ++ + P L+I A ++ G Y C A+N
Sbjct: 2606 TI-----------TWFKDGTPLESN--RNIRILPGGRTLQILNAQEDNAGRYSCVATNEA 2652
Query: 1074 GQASASADFDAQAVNV----QVW-PGATVREGQL-----VNLTCLVWTTHPAQLTYTWYQ 1123
G+ + + +W PG + +E ++ + L C + A L +WY+
Sbjct: 2653 GEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASL--SWYK 2710
Query: 1124 DGQQ---------RLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRN 1174
DGQ + H++ + + D Y C L + + V + +
Sbjct: 2711 DGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQK 2770
Query: 1175 L-RLTYLLES-HGGQLALVL--------CTVDSRPPAQLALSHAGRLLASSTAASV-PNT 1223
L + +L++ G+ V+ C ++ PP L G L SS + P
Sbjct: 2771 LWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGG 2830
Query: 1224 LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVT--- 1280
L++ + D G Y+C A + G+ + ++R+ +I + +PE + V
Sbjct: 2831 RVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSA 2890
Query: 1281 ---CADPAAHAPTLYTWYHNGRWLQE-------GPAASLSFLVATRAHAGAYSCQAQDAQ 1330
C + AP +W +G+ L E L L G Y C A++
Sbjct: 2891 LIECLSSGSPAPR-NSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTA 2949
Query: 1331 GTRSSRPAALQVLYAPQDAV--LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLAT 1388
G S++ ++ P + S + + C V PP +L+ + + +
Sbjct: 2950 G--SAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKL 3007
Query: 1389 SSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV 1448
++ + G +R +V D Y C A N G L V +
Sbjct: 3008 NTNTLIVPGGR-----TLQIIRAKVSD----GGEYTCIAINQAGESKKKFSLTVYVPPSI 3058
Query: 1449 AEPG------LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRL----HAEPVPTLAF 1498
+ ++V EG +++L C P PV W+ N R + H E +
Sbjct: 3059 KDHDSESLSVVNVREGTSVSLECESNAVPPPV----ITWYKNGRMITESTHVEILADGQM 3114
Query: 1499 THVARAQ---AGMYHCLAELPTGAAASAPVMLRVLYPP--KTPTMMVFVEPEGGLRGILD 1553
H+ +A+ G Y C A + L V PP + P V VE L
Sbjct: 3115 LHIKKAEVSDTGQYVCRA-INVAGRDDKNFHLNVYVPPSIEGPEREVIVETISN-PVTLT 3172
Query: 1554 CRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYIC 1613
C P ++ + + +S + V ++ I + SD G Y C
Sbjct: 3173 CDATGIPPPTIAWLKNHKRIENSD--------SLEVRILSGGSKLQIARSQHSDSGNYTC 3224
Query: 1614 SASNVLGSASTSTYFGVR 1631
ASN+ G A + ++
Sbjct: 3225 IASNMEGKAQKYYFLSIQ 3242
Score = 168 bits (425), Expect = 5e-41
Identities = 361/1530 (23%), Positives = 537/1530 (35%), Gaps = 288/1530 (18%)
Query: 250 RNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVL--------HLPQAAWSDAG 301
++++ ++L C+ N++ P ++ W KDG L + VL +P+A DAG
Sbjct: 2787 KDVIINNPISLYCETNAAPPP--TLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAG 2844
Query: 302 VYTCQAENGVGS--------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVC-NTPNEA 352
YTC A N G ++ PPI I A + +L N++ + C ++ + A
Sbjct: 2845 RYTCVAVNEAGEDSLQYDVRVLVPPI---IKGANSDLPEEVTVLVNKSALIECLSSGSPA 2901
Query: 353 PSDLRYSWYKN-HVLLEDAH------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVS 405
P R SW K+ LLED H L++ D G Y C +N GS + +
Sbjct: 2902 P---RNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKY-FN 2957
Query: 406 VVVNHPP---------LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTS 456
+ V+ PP LT V+ F+ L C V P L S
Sbjct: 2958 LNVHVPPSVIGPKSENLTVVVNNFIS--------LTCEVSGFPPPDL------------S 2997
Query: 457 GDSDHSPRFSGTSG---PNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARL 513
+ P T+ P L+I + +D GEY C A N G +
Sbjct: 2998 WLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS 3057
Query: 514 LISPAAE------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP-------GSSL 560
+ +E V EG +V+L C S P P +WY NG ++ E G L
Sbjct: 3058 IKDHDSESLSVVNVREGTSVSLECESNAVPPPV--ITWYKNGRMITESTHVEILADGQML 3115
Query: 561 LLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRG 620
+ A +D G Y CRA + A L V PP + ++
Sbjct: 3116 HIKKAEVSDTGQYVCRAIN--VAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPV---- 3169
Query: 621 LLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPL 680
L C PP + L + + S ++V +++I
Sbjct: 3170 TLTCDATGIPPPTIAWLKNHKRIENS--------------DSLEVRILSGGSKLQIARSQ 3215
Query: 681 LEEEGLYLCEASNALGNASTSATFNGQ---ATVLAIAPSH-TLQEGTEANLTCNVSREAA 736
+ G Y C ASN G A + Q + A PS ++ G L CN A
Sbjct: 3216 HSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCN----AN 3271
Query: 737 GSPANF-SWFRNGVLWAQGPLE---------TVTLLPVARTDAALYACRILTEAGAQLST 786
G P W ++G A G E T+ + +D Y C AG +
Sbjct: 3272 GIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEE-DR 3330
Query: 787 PVLLSVLYPP-------DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATS 839
L+V P + KL L+D C P + + L
Sbjct: 3331 IFNLNVYVTPTIRGNKDEAEKLMTLVDTSIN----IECRATGTPPPQI------NWLKNG 3380
Query: 840 LGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQ 899
L + SH R A + + + + D Y C A+N G N QV A
Sbjct: 3381 LPLPLSSHIRLLAAGQV----IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVF-APPN 3435
Query: 900 VSPSPELQE-----GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLT- 953
+ S +E G + ++C + G P S W RDGQPL T+ + L
Sbjct: 3436 MDNSMGTEEITVLKGSSTSMAC-ITDGTP-APSMAWLRDGQPLGLDAHLTVSTHGMVLQL 3493
Query: 954 ------QAGAYHCQAQAPGSATTS---LAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLL 1004
+G Y C A + L H++ + H ++ +++ L
Sbjct: 3494 LKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLE----LT 3549
Query: 1005 CRVDSDPPAQLRLLHGDRLVAST--LQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDE 1062
C P ++ + R + T +Q +GG E L I A +ED
Sbjct: 3550 CIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEV---------------LRISTAQVEDT 3594
Query: 1063 GVYICEASNTLGQASASADFDAQAVNVQVWPGA---------TVREGQLVNLTCLVWTTH 1113
G Y C AS+ G D V V V P TV + V L C
Sbjct: 3595 GRYTCLASSPAGD-----DDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVP 3649
Query: 1114 PAQLTYTWYQDGQQRLDA----------HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRP 1163
P +T W ++G+ RL A + + N + D +Y C A + +R
Sbjct: 3650 PPVIT--WLRNGE-RLQATPRVRILSGGRYLQINNADLGDTANYTCVAS--NIAGKTTRE 3704
Query: 1164 ITLDVLYAPRNLRLTYLLESHGGQLALVL---------CTVDSRPPAQLALSHAGRLLAS 1214
L V P N++ GG +LV+ C + P ++ G +LA
Sbjct: 3705 FILTV-NVPPNIK--------GGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAG 3755
Query: 1215 STAA-SVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP---EAA 1270
+ A S+ L ++ D G Y C A + G ++L++ V +AP
Sbjct: 3756 NHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVH-VPPSIAPGPTNMT 3814
Query: 1271 VPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGP---------AASLSFLVATRAHAGA 1321
V T+ C P++ W NG L + SL + +
Sbjct: 3815 VIVNVQTTLACEATGIPKPSI-NWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTAT 3873
Query: 1322 YSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSH 1381
Y C + G R L V P A + + AVI CT P + +
Sbjct: 3874 YECTVTNGAGD-DKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTK 3932
Query: 1382 DG-KVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRL 1440
+G ++L G L+SG + L Q AG Y C A+N GS L
Sbjct: 3933 NGIRLLPRGDGYRILSSGAIEI--------LATQLNHAG--RYTCVARNAAGSAHRHVTL 3982
Query: 1441 QVEGARVVA-EPG-LDVPEGAALNLSCRLLGGPGPVGNSTFAW------FWNDRRLHAE- 1491
V V+ +P L V + L C G P P W R HA
Sbjct: 3983 HVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPF----ITWQKEGINVNTSGRNHAVL 4038
Query: 1492 PVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPK-TPTMMVFV----EPEG 1546
P L + R AG Y C+A+ P G A + L V PP +P + +V +P
Sbjct: 4039 PSGGLQISRAVREDAGTYMCVAQNPAGTALGK-IKLNVQVPPVISPHLKEYVIAVDKPI- 4096
Query: 1547 GLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPS 1606
L C D P +T H R + S Q VL+S + + I ++P
Sbjct: 4097 ----TLSCEADGLPPPDITWHKDGRAIVESIRQ--------RVLSSGS---LQIAFVQPG 4141
Query: 1607 DQGEYICSASNVLGSASTSTYFGVRALHRL 1636
D G Y C A+NV GS+STST V R+
Sbjct: 4142 DAGHYTCMAANVAGSSSTSTKLTVHVPPRI 4171
Score = 164 bits (416), Expect = 5e-40
Identities = 330/1485 (22%), Positives = 537/1485 (36%), Gaps = 233/1485 (15%)
Query: 251 NILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV--------LHLPQAAWSDAGV 302
N+ G V+L C+ N+ P V I W K+G + T V LH+ +A SD G
Sbjct: 3070 NVREGTSVSLECESNAVPPPV--ITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQ 3127
Query: 303 YTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILE---NQTVTLVCNTPNEAPSDLRYS 359
Y C+A N G L++++ P ++ + VTL C+ P + +
Sbjct: 3128 YVCRAINVAGR-DDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTI--A 3184
Query: 360 WYKNHVLLEDAHS---------HTLRLHLATRADTGFYFCEVQNVHG-SERSGPVSVVVN 409
W KNH +E++ S L++ + +D+G Y C N+ G +++ +S+ V
Sbjct: 3185 WLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVP 3244
Query: 410 HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTS 469
+ + + G L C+ P + G +AS G+++ R S
Sbjct: 3245 PSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIAS--GETERI-RVSA-- 3299
Query: 470 GPNSLRLEIRDLEETDSGEYKCSATNSLGN----------ATSTLDFHANAARLLISPAA 519
N L I +D+G+Y C ATN G T T+ + + A L++
Sbjct: 3300 --NGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMT--- 3354
Query: 520 EVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP-------GSSLLLPAASSTDAGS 572
+ ++ + CR+ + TP + +W NG L G + + A +D
Sbjct: 3355 --LVDTSINIECRA--TGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAV 3410
Query: 573 YHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPA 632
Y C A + A + L V PP ++ G + C D P
Sbjct: 3411 YTCVA--SNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVL---KGSSTSMACITDGTPAP 3465
Query: 633 RLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEAS 692
+ L + + L + ST G LL+ E E+ G Y C AS
Sbjct: 3466 SMAWLRDGQPLG--LDAHLTVSTHG---------MVLQLLKAET-----EDSGKYTCIAS 3509
Query: 693 NALGNASTSATFNGQATVLAIAPSHT--LQEGTEANLTCNVSRE----AAGSPA-NFSWF 745
N G S + P H +E E ++ N E A+G PA +W
Sbjct: 3510 NEAGEVSKHFILK------VLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWM 3563
Query: 746 RNGVLWAQ-------GPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPP-- 796
++G Q G E + + D Y C + AG L+ V PP
Sbjct: 3564 KDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDD-DKEYLVRVHVPPNI 3622
Query: 797 ---DRPKLSALLDMGQGHMALFICTVDSRPLALLA-LFHGEHLLATSLGPQVPSHGRFQA 852
D P+ +L + C D+ P ++ L +GE L AT ++ S GR+
Sbjct: 3623 AGTDEPRDITVL---RNRQVTLECKSDAVPPPVITWLRNGERLQATPR-VRILSGGRY-- 3676
Query: 853 KAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPE---LQEG 909
L++ LGD+ +Y C A+N+ G + V + P+ +
Sbjct: 3677 --------LQINNADLGDTANYTCVASNIAGKTTREFILTVNVP-PNIKGGPQSLVILLN 3727
Query: 910 QAVVLSCQVHTGVPEGTSYRWYRDGQPLQES-------TSATLRFAAITLTQAGAYHCQA 962
++ VL C + GVP W +DG L + + L + +T G Y C A
Sbjct: 3728 KSTVLEC-IAEGVPT-PRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMA 3785
Query: 963 -QAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGD 1021
A G+ + + + S AP +T +++ L C P +
Sbjct: 3786 TNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQT----TLACEATGIPKPSINWRKNG 3841
Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAML------EDEGVYICEASNTLGQ 1075
L L+V N+ RL G+++ +D Y C +N G
Sbjct: 3842 HL-----------------LNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGD 3884
Query: 1076 ASASADFDAQA-----------VNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQD 1124
+ D Q + + P V + WT + +L D
Sbjct: 3885 DKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRG--D 3942
Query: 1125 GQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV----LYAPRNLRLTYL 1180
G + L + +I + + A Y C A R +TL V + P+ L +
Sbjct: 3943 GYRILSSGAIEILATQLNHAGRYTCVAR--NAAGSAHRHVTLHVHEPPVIQPQPSELHVI 4000
Query: 1181 LESHGGQLALVLCTVDSRPPAQLALSHAG-RLLASSTAASVPNTLRLELRGPQPRDEGFY 1239
L + L+ C P + G + S +V + L++ D G Y
Sbjct: 4001 LNNP----ILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTY 4056
Query: 1240 SCSARSPLGQANTSLELRLEGVRVILAP---EAAVPEGAPITVTCADPAAHAPTLYTWYH 1296
C A++P G A ++L ++ V +++P E + PIT++C P + TW+
Sbjct: 4057 MCVAQNPAGTALGKIKLNVQ-VPPVISPHLKEYVIAVDKPITLSCEADGLPPPDI-TWHK 4114
Query: 1297 NGRWLQEG------PAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAV 1350
+GR + E + SL AG Y+C A + G+ SS L V P+
Sbjct: 4115 DGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGS-SSTSTKLTVHVPPRIRS 4173
Query: 1351 LSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR 1410
S A++ C D P + D +LA G ++ A
Sbjct: 4174 TEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYT----------AEPYGE 4223
Query: 1411 LQVQDVPAGDDT-YVCTAQNLLGSISTIGRLQVEGARVVAE-PG-LDVPEGAALNLSCRL 1467
L +++V D Y C A N G + L V E PG + + +G L LSC+
Sbjct: 4224 LILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKA 4283
Query: 1468 LGGPGPVGNSTFAWFWNDRRL--HAEPV---PTLAFTHVARAQAGMYHCLAELPTGAAAS 1522
G P P W +N+ + H + V L V++ +G Y C AE G
Sbjct: 4284 TGIPLP----KLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFV-K 4338
Query: 1523 APVMLRVLYPP--KTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQG 1580
A + V PP K ++EP GG IL+C V +P ++ + + S
Sbjct: 4339 AIGFVYVKEPPVFKGDYPSNWIEPLGG-NAILNCEVKGDPTPTIQWNRKGVDIEISHRIR 4397
Query: 1581 APAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTS 1625
+ + + N D G+Y C A+N G S
Sbjct: 4398 QLGNGSLAIYGTVN-----------EDAGDYTCVATNEAGVVERS 4431
Score = 162 bits (411), Expect = 2e-39
Identities = 366/1673 (21%), Positives = 582/1673 (34%), Gaps = 308/1673 (18%)
Query: 99 NLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDF 158
+L LK ++ D+G Y+ SE S +TV E P+V + G+EV
Sbjct: 575 SLELKSVKFNDAGEYHCMVS-SEGG--SSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSI 631
Query: 159 NCS-TPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRC 217
CS T Y + ++ W D S ++ T G TL + + I C
Sbjct: 632 MCSATGY----PKPKIAWTVND---MFIVGSHRYRMTSDG---TLFIKNAAPKDAGIYGC 681
Query: 218 QLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWL 277
S + + L+ AP K+++ S + G++ + C+ + P +KW
Sbjct: 682 LASNSAGTDKQNSTLRYIEAP---KLMVVQSELLVALGDITVMECKTSGIPP--PQVKWF 736
Query: 278 KDGVRLQTKT--------GVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQ 329
K + L+ T G+L + + DAG YTC A N G + I+L + V
Sbjct: 737 KGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGR-ATGKITLDVGSPPVF 795
Query: 330 V-SPAGPILE-NQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRA---- 383
+ PA +E VTL C +++ N + S + L T A
Sbjct: 796 IQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFIL 855
Query: 384 -----DTGFYFCEVQNVHGSERS-GPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVS 437
D G Y CE +N G +S V+V PL + + G L C++++
Sbjct: 856 NLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLA 915
Query: 438 -EPLA-------TLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEY 489
P+ + +L +I + G L I ++ D GEY
Sbjct: 916 GNPIPERRWIKNSAMLLQNPYITVRSDGS-----------------LHIERVQLQDGGEY 958
Query: 490 KCSATNSLG--NATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYL 547
C A+N G N T+++ H +EG VTL C++ +P P W
Sbjct: 959 TCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSV--IWSK 1016
Query: 548 NGALL-------HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQ 600
G L+ G SL + + ++G Y C A ++A LTV PR
Sbjct: 1017 KGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTAT--NTAGYAKRKVQLTVYVRPRV 1074
Query: 601 PTFTTRLDLD---AAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVA------TSLPSGG 651
L D AG L C V S PP + + ++++ T LPSG
Sbjct: 1075 FGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGS 1134
Query: 652 GCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQA-TV 710
MK+T+ + G+YLC A+N GN + + N
Sbjct: 1135 -----------MKITETRT-----------SDSGMYLCVATNIAGNVTQAVKLNVHVPPK 1172
Query: 711 LAIAPSH-TLQEGTEANLTCNVSREAAGSPAN-FSWFRNGVLW-------AQGPLETVTL 761
+ P H +Q G ++ CN A G+P +W + G P T+++
Sbjct: 1173 IQRGPKHLKVQVGQRVDIPCN----AQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSI 1228
Query: 762 LPVARTDAALYACRILTEAGAQLSTPVLLSVLYPP-----DRPKLSALLDMGQGHMALFI 816
+DA +Y C AG T + L V PP + P + + F
Sbjct: 1229 DQATPSDAGIYTCVATNIAGTD-ETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFP 1287
Query: 817 CTVDSRPLALLALFH-GEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYR 875
C P + H G L G + G L + + D+G Y
Sbjct: 1288 CPAKGTPKPTIKWLHNGRELTGREPGISILEDGTL----------LVIASVTPYDNGEYI 1337
Query: 876 CEATNVLGSSNTSLFFQVRGAWV----QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWY 931
C A N G++ +V V + + + Q L C+V G P WY
Sbjct: 1338 CVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVE-GTP-SPIIMWY 1395
Query: 932 RDGQPLQESTS-------ATLRFAAITLTQAGAYHCQA-QAPGSA----TTSLAAPISLH 979
+D + ES++ L+ T AG Y C+A G++ + P ++
Sbjct: 1396 KDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTII 1455
Query: 980 VSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSP 1039
+ P V++ D L C+V P + + + +G P
Sbjct: 1456 GTNFPNEVSVVLNRDVA------LECQVKGTPFPDIHWFKDGKPLF-----LGDP----- 1499
Query: 1040 RLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVRE 1099
+V + L + A D+G Y C SN G+ A+ + + ++ +++
Sbjct: 1500 --NVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGK-------QAKDIKLTIYIPPSIKG 1550
Query: 1100 G-----------QLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS---------IPLPNV 1139
G L+ L C T TWY+DGQ + + + +P
Sbjct: 1551 GNVTTDISVLINSLIKLEC--ETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRA 1608
Query: 1140 TVRDATSYRCGVG----------------PPGRAPRLSRPITLDVLYAPRNLRLTYLLES 1183
V D+ +Y C V PP L+ P+ V+ A LT ++
Sbjct: 1609 QVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAH---SLTLECKA 1665
Query: 1184 HGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSA 1243
G ++ D P + A+ +LE+ Q D G Y C A
Sbjct: 1666 AGNPSPILTWLKDGVP-----------VKANDNIRIEAGGKKLEIMSAQEIDRGQYICVA 1714
Query: 1244 RSPLGQANTSLELRLEGVRVILAPEAAVPEGAPIT------------VTCADPAAHAPTL 1291
S G+ E+ +L P A EG T + C + PT+
Sbjct: 1715 TSVAGEKEIKYEVD------VLVPPAI--EGGDETSYFIVMVNNLLELDCHVTGSPPPTI 1766
Query: 1292 YTWYHNGRWLQEGP-------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLY 1344
W +G+ + E L A ++ G Y C A + G +V
Sbjct: 1767 -MWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKE---FEVTV 1822
Query: 1345 APQDAVLSSFRDSRA---RSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGH 1401
+ SS R +QC + P + D + + T+ G + S
Sbjct: 1823 HVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRV 1882
Query: 1402 VQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAAL 1461
+Q+A+ L AG Y C A N G +L V + + G + E +
Sbjct: 1883 LQIAKTLLE------DAG--RYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLV 1934
Query: 1462 N----LSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTL----AFTHVARAQ---AGMYH 1510
+ L C+ G P PV W+ ++R L T + AQ AG+Y
Sbjct: 1935 SNPVQLECKAAGNPVPV----ITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYK 1990
Query: 1511 CLAELPTGAAASAPVMLRVLYPPKT--PTMMVFVEPEGGLRGILDCRVDSEPLASLT-LH 1567
C+A + + A L+V P MV V +R L+C P SLT L
Sbjct: 1991 CVA-INSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVR--LECEARGIPAPSLTWLK 2047
Query: 1568 LGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620
GS + + S + VL+ L + + + SD G Y C A N G
Sbjct: 2048 DGSPVSSFSN--------GLQVLSGGRILA--LTSAQISDTGRYTCVAVNAAG 2090
Score = 152 bits (385), Expect = 2e-36
Identities = 356/1584 (22%), Positives = 556/1584 (35%), Gaps = 303/1584 (19%)
Query: 199 LETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELV 258
L+ +H++ D GR + ++VA + L V P + SP +++ V
Sbjct: 2350 LKNIHVS----DTGRYVCVAVNVAG-MTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSV 2404
Query: 259 TLTCQVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTCQAENG 310
+LTC+ S P + SI W KDG VR+ + +L L Q DAG YTC N
Sbjct: 2405 SLTCEA-SGIP-LPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNA 2462
Query: 311 VGS---------LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCN-TPNEAPSDLRYSW 360
G LV P I + +V+V E Q+VTL C T N P +W
Sbjct: 2463 AGEERKIFGLSVLVPPHIVGENTLEDVKVK------EKQSVTLTCEVTGNPVP---EITW 2513
Query: 361 YKNHVLLEDAHSH-------TLRLHLATRADTGFYFCEVQNVHG-SERSGPVSVVVNHPP 412
+K+ L++ +H L++ TG Y C + G RS ++V V+ P
Sbjct: 2514 HKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVS-PT 2572
Query: 413 LTPV--------LTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPR 464
+ V +T L + LV C S P AT+ G T +S+ + R
Sbjct: 2573 IAGVGSDGNPEDVTVILNSPTSLV----CEAYSYPPATITWFKDG-----TPLESNRNIR 2623
Query: 465 FSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLL---------I 515
P L+I + +E ++G Y C ATN G + ++ +
Sbjct: 2624 IL----PGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGL 2679
Query: 516 SP-AAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHE-------GPGSSLLLPAASS 567
SP ++ +TL C + P A SWY +G L G +L + A
Sbjct: 2680 SPKEVKIKVNNTLTLECEA--YAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQI 2737
Query: 568 TDAGSYHCRARDGHSASGPSSPAVLTVLYPPR-QPTFTTRLDLDAAGAGAGRRGL----- 621
+D G Y C A + A + + PP Q + LD G + +
Sbjct: 2738 SDTGRYTCVA--SNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 622 -LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPL 680
L C ++ PP L +KD TS KV P ++I
Sbjct: 2796 SLYCETNAAPPPTL-TWYKDGHPLTSSD---------------KVLILPGGRVLQIPRAK 2839
Query: 681 LEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTE--ANLTCNVSREAAGS 738
+E+ G Y C A N G S + + L E N + + ++GS
Sbjct: 2840 VEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGS 2899
Query: 739 PA-NFSWFRNGVLWAQGPLE-----------TVTLLPVARTDAALYACRILTEAGAQLST 786
PA SW ++G Q LE + +L TD Y C AG+
Sbjct: 2900 PAPRNSWQKDG----QPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGS-AKK 2954
Query: 787 PVLLSVLYPPD--RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQV 844
L+V PP PK L + ++L C V P L+ E + + +
Sbjct: 2955 YFNLNVHVPPSVIGPKSENLTVVVNNFISL-TCEVSGFPPPDLSWLKNEQPIKLNTNTLI 3013
Query: 845 PSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPS- 903
GR L++ + D G Y C A N G S V V PS
Sbjct: 3014 VPGGR----------TLQIIRAKVSDGGEYTCIAINQAGESKKKF-----SLTVYVPPSI 3058
Query: 904 ----------PELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST-------SATLR 946
++EG +V L C+ + P + WY++G+ + EST L
Sbjct: 3059 KDHDSESLSVVNVREGTSVSLECESNAVPPPVIT--WYKNGRMITESTHVEILADGQMLH 3116
Query: 947 FAAITLTQAGAYHCQA---QAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLL 1003
++ G Y C+A L + + R V + T+ + L
Sbjct: 3117 IKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNP-----VTL 3171
Query: 1004 LCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEG 1063
C PP + L + + +S L V + +L+I + D G
Sbjct: 3172 TCDATGIPPPTIAWLKNHKRIE-----------NSDSLEVRILSGGSKLQIARSQHSDSG 3220
Query: 1064 VYICEASNTLGQAS----ASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTY 1119
Y C ASN G+A S ++ +V G+ V L C P L
Sbjct: 3221 NYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNA-NGIPTPL-I 3278
Query: 1120 TWYQDGQQ---------RLDAH--SIPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLD 1167
W +DG+ R+ A+ ++ + D Y C P G R+ L+
Sbjct: 3279 QWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRI---FNLN 3335
Query: 1168 VLYAPR---NLRLTYLLESHGGQLALVLCTVDSRPPAQ---------LALSHAGRLLASS 1215
V P N L + + C PP Q L LS RLLA+
Sbjct: 3336 VYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAG 3395
Query: 1216 TAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP-------- 1267
+ Q D Y+C A + G N L+ + AP
Sbjct: 3396 QVIRIVRA--------QVSDVAVYTCVASNRAGVDNKHYNLQ------VFAPPNMDNSMG 3441
Query: 1268 --EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLS-------FLVATRAH 1318
E V +G+ ++ C AP++ W +G+ L ++S L A
Sbjct: 3442 TEEITVLKGSSTSMACITDGTPAPSM-AWLRDGQPLGLDAHLTVSTHGMVLQLLKAETED 3500
Query: 1319 AGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV-----IQCTVDSEP 1373
+G Y+C A + G S+ L+VL P ++ + S+ V + C P
Sbjct: 3501 SGKYTCIASNEAG-EVSKHFILKVLEPPH---INGSEEHEEISVIVNNPLELTCIASGIP 3556
Query: 1374 PAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDT--YVCTAQNLL 1431
++ DG+ L + V +L G LR+ V +DT Y C A +
Sbjct: 3557 APKMTWMKDGRPLPQTDQVQTLGGG--------EVLRISTAQV---EDTGRYTCLASSPA 3605
Query: 1432 GSISTIGRLQVEGARVVA---EP-GLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRR 1487
G ++V +A EP + V + L C+ P PV W N R
Sbjct: 3606 GDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV----ITWLRNGER 3661
Query: 1488 LHAEPVPTL----AFTHVARAQAG---MYHCLAELPTGAAASAPVMLRVLYPPKT---PT 1537
L A P + + + A G Y C+A G + +L V PP P
Sbjct: 3662 LQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAG-KTTREFILTVNVPPNIKGGPQ 3720
Query: 1538 MMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALR 1597
+V + + +L+C + P +T ++A + + + E
Sbjct: 3721 SLVILLNKS---TVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGF---------- 3767
Query: 1598 VDIEALRPSDQGEYICSASNVLGS 1621
+ I++ +D G Y+C A+N G+
Sbjct: 3768 LHIQSAHVTDTGRYLCMATNAAGT 3791
Score = 145 bits (366), Expect = 3e-34
Identities = 352/1654 (21%), Positives = 589/1654 (35%), Gaps = 263/1654 (15%)
Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159
L +++ Q D+G Y I+E R G + P V I P ++ E+ N
Sbjct: 757 LKIQETQDLDAGDYTC-VAINEAGR---ATGKITLDVGSPPV-FIQEPADV--SMEIGSN 809
Query: 160 CSTP-YVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLET--LHMAMSWQDHGRILR 216
+ P YV + ++W+ D ++ S+ F + + L T L + W
Sbjct: 810 VTLPCYVQGYPEPTIKWRRLD---NMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYI 866
Query: 217 CQLSVANHRAQSEIHLQVK--YAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSI 274
C+ + QSE + V AP I +SPS N++ G+ +TL C + + P +
Sbjct: 867 CEAENQFGKIQSETTVTVTGLVAPL---IGISPSVANVIEGQQLTLPCTLLAGNP-IPER 922
Query: 275 KWLKDGVRLQTKT-------GVLHLPQAAWSDAGVYTCQAENGVGSL-VSPPISLHIFMA 326
+W+K+ L G LH+ + D G YTC A N G+ + + +H+
Sbjct: 923 RWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPT 982
Query: 327 EVQVSPAGPILENQTVTLVCNTP-NEAPSDLRYSWYKNHVLLEDAHSH-------TLRLH 378
+E VTL C N PS + W K L+ + + +L +
Sbjct: 983 IQHGQQILSTIEGIPVTLPCKASGNPKPSVI---WSKKGELISTSSAKFSAGADGSLYVV 1039
Query: 379 LATRADTGFYFCEVQNVHG-SERSGPVSVVV------NHPPLTPVLTAFLETQAGLVGIL 431
++G Y C N G ++R ++V V + L+ + AG L
Sbjct: 1040 SPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTL 1099
Query: 432 HCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKC 491
C V S P + + ++ S SPR + + ++I + +DSG Y C
Sbjct: 1100 PCEVKSLPPPIITWAKETQLI------SPFSPRHTFLPSGS---MKITETRTSDSGMYLC 1150
Query: 492 SATNSLGNATSTLDFHANA-ARLLISPA-AEVVEGQAVTLSCRSGLSPTPDARFSWYLNG 549
ATN GN T + + + ++ P +V GQ V + C + +P P +W G
Sbjct: 1151 VATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLP--VITWSKGG 1208
Query: 550 A-LLHEG------PGSSLLLPAASSTDAGSYHCRAR------DGHSASGPSSPAVLTVLY 596
+ +L +G P +L + A+ +DAG Y C A + P + L
Sbjct: 1209 STMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLE 1268
Query: 597 PPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTC 656
PP TF R+ A +R C P ++ LH R +
Sbjct: 1269 PPYNTTFQERV--------ANQRIEFPCPAKGTPKPTIKWLHNGRELT------------ 1308
Query: 657 GGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPS 716
G P + + + LL + P + G Y+C A N G +
Sbjct: 1309 -GREPGISILEDGTLLVIASVTPY--DNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKE 1365
Query: 717 HTLQEGTEANLTCNVSREAAGSPAN-FSWFRNGV-LWAQGPLETVT------LLPVARTD 768
N N+ E G+P+ W+++ V + ++TV L D
Sbjct: 1366 QVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPED 1425
Query: 769 AALYACRILTEAGAQ--------LSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVD 820
A Y+C+ + AG L P ++ +P + +S +L+ C V
Sbjct: 1426 AGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNE---VSVVLNRD----VALECQVK 1478
Query: 821 SRPLALLALF-HGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEAT 879
P + F G+ L ++ G+ L ++ D G Y+C +
Sbjct: 1479 GTPFPDIHWFKDGKPLFLGDPNVELLDRGQV----------LHLKNARRNDKGRYQCTVS 1528
Query: 880 NVLGSSNTSLFF------QVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRD 933
N G + ++G V+ + + L C+ G+P + WY+D
Sbjct: 1529 NAAGKQAKDIKLTIYIPPSIKGG--NVTTDISVLINSLIKLECETR-GLPM-PAITWYKD 1584
Query: 934 GQPLQESTSA----------------------TLRFAAITLTQAGAYHCQAQAPGSATTS 971
GQP+ S+ A T A + T ++H P +
Sbjct: 1585 GQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGN 1644
Query: 972 LAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGV 1031
LA P++ V A +LT L C+ +P L L
Sbjct: 1645 LATPLNKQVVIAH---SLT------------LECKAAGNPSPILTWLKD----------- 1678
Query: 1032 GGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQV 1091
G P ++ + + +LEI A D G YIC A++ G+ + D
Sbjct: 1679 GVPVKANDNIRIEAGGK--KLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIE 1736
Query: 1092 WPGAT----VREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ---------RLDAHSIPLPN 1138
T V L+ L C V + P T W +DGQ L+ + +
Sbjct: 1737 GGDETSYFIVMVNNLLELDCHVTGSPPP--TIMWLKDGQLIDERDGFKILLNGRKLVIAQ 1794
Query: 1139 VTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSR 1198
V + YRC + +T+ V ++ L+ + +AL C +
Sbjct: 1795 AQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVAL-QCIANGI 1853
Query: 1199 P-PAQLALSHAGRLLASSTAASVPNTLR-LELRGPQPRDEGFYSCSARSPLGQANTSLEL 1256
P P+ L + + + ++ R L++ D G Y+C A + G+ ++L
Sbjct: 1854 PNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQL 1913
Query: 1257 R------LEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLS 1310
LE +L V P+ + C P + TWY + R L + S++
Sbjct: 1914 HVHEPPSLEDAGKMLNETVLVSN--PVQLECKAAGNPVPVI-TWYKDNRLL--SGSTSMT 1968
Query: 1311 FL---------VATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARS 1361
FL A + AG Y C A ++ G + +LQV AP + ++ +
Sbjct: 1969 FLNRGQIIDIESAQISDAGIYKCVAINSAGA-TELFYSLQVHVAPSISGSNNMVAVVVNN 2027
Query: 1362 MAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD 1421
++C P L DG +++ S + SG G + +A Q+ D
Sbjct: 2028 PVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSG-GRILALTSA---QISDT----G 2079
Query: 1422 TYVCTAQNLLG--SISTIGRLQVEGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTF 1479
Y C A N G R+ V + E + V A+ L C+ P P T
Sbjct: 2080 RYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPP----TL 2135
Query: 1480 AWFWNDRRLHAEPVPTL----AFTHVARAQ---AGMYHCLAELPTGAAASAPVMLRVLYP 1532
W + L +P ++ + + AQ G Y C A G + + P
Sbjct: 2136 TWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAG-KTEKNYNVNIWVP 2194
Query: 1533 PK---TPTMMVFVEPEGGLRGILDCRVDSEPLASLT-LHLGSRLVASSQPQGAPAEPHIH 1588
P + + EG L +L C P +L GS ++ S + +
Sbjct: 2195 PNIGGSDELTQLTVIEGNLISLL-CESSGIPPPNLIWKKKGSPVLTDSMGR-------VR 2246
Query: 1589 VLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
+L+ L++ I SD Y C ASNV G+A
Sbjct: 2247 ILSGGRQLQISI--AEKSDAALYSCVASNVAGTA 2278
Score = 141 bits (356), Expect = 5e-33
Identities = 361/1677 (21%), Positives = 590/1677 (35%), Gaps = 290/1677 (17%)
Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKG-TLVTVTE--EPRVPTIASPVELLEGTEV 156
L + +L D G+Y E N++ ++ T VTVT P + S ++EG ++
Sbjct: 852 LFILNLWASDKGTYICEAE----NQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQL 907
Query: 157 DFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKF--------EPTGVGHLETLHMAMSW 208
C+ L P R NS G H+E + +
Sbjct: 908 TLPCT-----------LLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQL---- 952
Query: 209 QDHGRILRCQLSVA--NHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNS 266
QD G +VA N++ S + + G +IL + + G VTL C+ +
Sbjct: 953 QDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQIL------STIEGIPVTLPCKASG 1006
Query: 267 SYPAVSSIKWLKDGVRLQTKT--------GVLHLPQAAWSDAGVYTCQAENGVGSL---- 314
+ S+ W K G + T + G L++ ++G Y C A N G
Sbjct: 1007 N--PKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKV 1064
Query: 315 -VSPPISLHIFMAEVQVSPAGPI----LENQTVTLVCNTPNEAPSDLRYSWYKNHVLLED 369
++ + +F + +S P+ L + VTL C + P + +W K L+
Sbjct: 1065 QLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPII--TWAKETQLISP 1122
Query: 370 AH-------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLE 422
S ++++ +D+G Y C N+ G+ V + V+ PP L+
Sbjct: 1123 FSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQA-VKLNVHVPPKIQRGPKHLK 1181
Query: 423 TQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLE 482
Q G + C+ PL + S GG + D +H S P+ L I
Sbjct: 1182 VQVGQRVDIPCNAQGTPLPVITWSKGGSTMLV---DGEHH-----VSNPDGT-LSIDQAT 1232
Query: 483 ETDSGEYKCSATNSLGNATSTLDFHANAARLL--ISPA-----AEVVEGQAVTLSCRSGL 535
+D+G Y C ATN G + + H + + P E V Q + C +
Sbjct: 1233 PSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKG 1292
Query: 536 SPTPDARFSWYLNGA-LLHEGPGSSLL-----LPAASST--DAGSYHCRARDGHSASGPS 587
+P P + W NG L PG S+L L AS T D G Y C A + +G +
Sbjct: 1293 TPKPTIK--WLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVN---EAGTT 1347
Query: 588 SPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSL 647
++ P P + + + L C V+ P + + + +KD V T
Sbjct: 1348 ERKYNLKVHVP--PVIKDKEQVTNVSVLLNQLTNLFCEVEGTP-SPIIMWYKDNVQVTE- 1403
Query: 648 PSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQ 707
S ++ +L++ P E+ G Y C+A N G + +
Sbjct: 1404 ------------SSTIQTVNNGKILKLFRATP--EDAGRYSCKAINIAGTSQKYFNIDVL 1449
Query: 708 ATVLAIAPSHTLQEGTEANLTCNVSREAAGSP-ANFSWFRNGV-LWAQGPL-------ET 758
I + + N + + G+P + WF++G L+ P +
Sbjct: 1450 VPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV 1509
Query: 759 VTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICT 818
+ L R D Y C + AG Q + + L++ PP + D+ +L
Sbjct: 1510 LHLKNARRNDKGRYQCTVSNAAGKQ-AKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLE 1568
Query: 819 VDSRPLALLALF---HGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYR 875
++R L + A+ G+ ++++S QA L + + DS +Y
Sbjct: 1569 CETRGLPMPAITWYKDGQPIMSSS-----------QALYIDKGQYLHIPRAQVSDSATYT 1617
Query: 876 CEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQV---HTGVPEGTS----- 927
C NV G++ S V V P ++ A L+ QV H+ E +
Sbjct: 1618 CHVANVAGTAEKSFH-------VDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPS 1670
Query: 928 --YRWYRDGQPLQ-------ESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISL 978
W +DG P++ E+ L + G Y C A + + + + +
Sbjct: 1671 PILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSV-AGEKEIKYEVDV 1729
Query: 979 HVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSS 1038
V A T+ L L C V PP + L +L+
Sbjct: 1730 LVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLI-------------D 1776
Query: 1039 PRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVR 1098
R + N +L I A + + G+Y C A+NT G + V V V P T++
Sbjct: 1777 ERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFE-----VTVHVPP--TIK 1829
Query: 1099 EGQLVNLTCLVWTTHPAQL--------TYTWYQDGQQRLDAHS----------IPLPNVT 1140
L + + Q + TW +D Q A + +
Sbjct: 1830 SSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTL 1889
Query: 1141 VRDATSYRCGVGPPGRAPRLSRPITLDVLYAP------RNLRLTYLLESHGGQLALVLCT 1194
+ DA Y C A + I L V P + L T L+ S+ QL C
Sbjct: 1890 LEDAGRYTCVA--TNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLV-SNPVQLE---CK 1943
Query: 1195 VDSRPPAQLALSHAGRLLASSTAASVPNTLRL-ELRGPQPRDEGFYSCSARSPLGQANTS 1253
P + RLL+ ST+ + N ++ ++ Q D G Y C A + G
Sbjct: 1944 AAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELF 2003
Query: 1254 LELRLEGVRVILAPE--AAVPEGAPITVTCADPAAHAPTLYTW---------YHNGRWLQ 1302
L++ I AV P+ + C AP+L TW + NG +
Sbjct: 2004 YSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSL-TWLKDGSPVSSFSNGLQVL 2062
Query: 1303 EGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSM 1362
G L+ A + G Y+C A +A G + R L+V Y P + + S S
Sbjct: 2063 SG-GRILALTSAQISDTGRYTCVAVNAAGEKQ-RDIDLRV-YVPPNIMGEEQNVSVLISQ 2119
Query: 1363 AV-IQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD 1421
AV + C D+ PP L DG L G+ ++ N L+++D D
Sbjct: 2120 AVELLCQSDAIPPPTLTWLKDGHPLLKKPGL----------SISENRSVLKIEDAQVQDT 2169
Query: 1422 -TYVCTAQNLLGSISTIGRLQV------EGARVVAEPGLDVPEGAALNLSCRLLGGPGPV 1474
Y C A N+ G + + G+ + + L V EG ++L C G P P
Sbjct: 2170 GRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQ--LTVIEGNLISLLCESSGIPPP- 2226
Query: 1475 GNSTFAWFWNDRRLHAEPVPT--------------LAFTHVARAQAGMYHCLAELPTGAA 1520
W + PV T L + ++ A +Y C+A G A
Sbjct: 2227 ---NLIW-----KKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTA 2278
Query: 1521 ASAPVMLRVLYPPKT-----PTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVAS 1575
+ + P T PT ++ G L+C V P ++T +
Sbjct: 2279 KKEYNLQVYIRPTITNSGSHPTEIIVTR---GKSISLECEVQGIPPPTVTWMKDGHPLIK 2335
Query: 1576 SQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRA 1632
++ E HI + ++ + SD G Y+C A NV G V A
Sbjct: 2336 AKGVEILDEGHI----------LQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHA 2382
Score = 138 bits (347), Expect = 5e-32
Identities = 344/1597 (21%), Positives = 547/1597 (34%), Gaps = 267/1597 (16%)
Query: 146 SPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETL--- 202
S V + EGT V C + V P +T+ T H+E L
Sbjct: 3067 SVVNVREGTSVSLECESNAV--------------PPPVITWYKNGRMITESTHVEILADG 3112
Query: 203 ---HMAMSW-QDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILP--GE 256
H+ + D G+ + ++VA R HL V Y P ++ P I+
Sbjct: 3113 QMLHIKKAEVSDTGQYVCRAINVAG-RDDKNFHLNV-YVPPSIE---GPEREVIVETISN 3167
Query: 257 LVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTCQ 306
VTLTC P +I WLK+ R++ + L + ++ SD+G YTC
Sbjct: 3168 PVTLTCDATGIPPP--TIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCI 3225
Query: 307 AENGVG--------SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRY 358
A N G S+ PP +A ++ +L + V LVCN N P+ L
Sbjct: 3226 ASNMEGKAQKYYFLSIQVPPS-----VAGAEIPSDVSVLLGENVELVCNA-NGIPTPL-I 3278
Query: 359 SWYKN---------HVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSE-RSGPVSVVV 408
W K+ + A+ TL ++ A +DTG Y C N G E R ++V V
Sbjct: 3279 QWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYV 3338
Query: 409 NHPPLTPVLTAFLETQAGLVGILHCSVVSEPLAT-------------LVLSHGGHILAST 455
TP + + L+ ++ S+ E AT L L HI
Sbjct: 3339 -----TPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLA 3393
Query: 456 SGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG--NATSTLDFHA--NAA 511
+G + I + +D Y C A+N G N L A N
Sbjct: 3394 AGQV----------------IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMD 3437
Query: 512 RLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGA-------LLHEGPGSSLLLPA 564
+ + V++G + +++C + +P P +W +G L G L L
Sbjct: 3438 NSMGTEEITVLKGSSTSMACITDGTPAPS--MAWLRDGQPLGLDAHLTVSTHGMVLQLLK 3495
Query: 565 ASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLC 624
A + D+G Y C A + A S +L VL PP ++ L L
Sbjct: 3496 AETEDSGKYTCIA--SNEAGEVSKHFILKVLEPPHINGSEEHEEISVIV----NNPLELT 3549
Query: 625 RVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEE 684
+ S PA KD LP T GG +LR+ +E+
Sbjct: 3550 CIASGIPAPKMTWMKD---GRPLPQTDQVQTLGG----------GEVLRISTAQ--VEDT 3594
Query: 685 GLYLCEASNALGNASTSATFNGQATVLAIAPSH----TLQEGTEANLTCNVSREAAGSPA 740
G Y C AS+ G+ T+ + L C + A P
Sbjct: 3595 GRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLEC---KSDAVPPP 3651
Query: 741 NFSWFRNGVLWAQGPLETVTLLPVART---------DAALYACRILTEAGAQLSTPVLLS 791
+W RNG P V +L R D A Y C + + + + +L+
Sbjct: 3652 VITWLRNGERLQATP--RVRILSGGRYLQINNADLGDTANYTC-VASNIAGKTTREFILT 3708
Query: 792 VLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQ 851
V PP+ L + + C + P + +LA + H R+
Sbjct: 3709 VNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGN-------HARYS 3761
Query: 852 AKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE--- 908
L ++ + D+G Y C ATN G+ + QV ++P P
Sbjct: 3762 ILENGF---LHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVP-PSIAPGPTNMTVIV 3817
Query: 909 GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQES---------TSATLRFAAITLTQAGAYH 959
L+C+ TG+P+ S W ++G L +S +L + ++ Y
Sbjct: 3818 NVQTTLACEA-TGIPK-PSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYE 3875
Query: 960 C---QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDP-PAQL 1015
C T L + ++ P +T ++ C P P+
Sbjct: 3876 CTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPA------VITCTASGVPFPSIH 3929
Query: 1016 RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQ 1075
+G RL+ P G R+ + A +EI L G Y C A N G
Sbjct: 3930 WTKNGIRLL---------PRGDGYRILSSGA-----IEILATQLNHAGRYTCVARNAAGS 3975
Query: 1076 ASASADFDAQAVNVQVWPGATVREGQLVNLTCLVW-TTHPAQLTYTWYQDG--------- 1125
A V + P + L N L T TW ++G
Sbjct: 3976 AHRHVTLHVHEPPV-IQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRN 4034
Query: 1126 QQRLDAHSIPLPNVTVRDATSYRC-GVGPPGRA-PRLSRPITLDVLYAPRNLRLTYLLES 1183
L + + + DA +Y C P G A ++ + + + +P ++
Sbjct: 4035 HAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDK 4094
Query: 1184 HGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSA 1243
+ C D PP + GR + S V ++ L++ QP D G Y+C A
Sbjct: 4095 P----ITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMA 4150
Query: 1244 RSPLGQANTSLELRLEGVRVILAPEA--AVPEGAPITVTCADPAAHAPTLYTWYHN---- 1297
+ G ++TS +L + I + E V E + + C P + W +
Sbjct: 4151 ANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAI-NWKKDNVLL 4209
Query: 1298 ----GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSS 1353
G++ E P L +G Y+C A +A G + +L V P L
Sbjct: 4210 ANLLGKYTAE-PYGELILENVVLEDSGFYTCVANNAAG-EDTHTVSLTVHVLPTFTELPG 4267
Query: 1354 FRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQV 1413
+ C P +L + + ++ S GH ++ R+
Sbjct: 4268 DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPA-----HFDSVNGHSELVIE--RVSK 4320
Query: 1414 QDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVA---EPGLDVPEGAALNLSCRLLGG 1470
+D TYVCTA+N +G + IG + V+ V P G L+C + G
Sbjct: 4321 ED----SGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGD 4376
Query: 1471 PGPVGNSTFAW------FWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAP 1524
P P T W R+ +LA AG Y C+A G +
Sbjct: 4377 PTP----TIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERS- 4431
Query: 1525 VMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAE 1584
+ L + PP V G + IL+C+ EP ++T S Q +
Sbjct: 4432 MSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITW--------SRQGHSISWD 4483
Query: 1585 PHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621
++VL++ + D + D E+ C A N++GS
Sbjct: 4484 DRVNVLSNNSLYIADAQ---KEDTSEFECVARNLMGS 4517
Score = 134 bits (337), Expect = 8e-31
Identities = 337/1500 (22%), Positives = 518/1500 (34%), Gaps = 233/1500 (15%)
Query: 245 LSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV--------LHLPQAA 296
LSP I +TL C+ + A S+ W KDG L++ V L + +A
Sbjct: 2679 LSPKEVKIKVNNTLTLECEAYAIPSA--SLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQ 2736
Query: 297 WSDAGVYTCQAENGVG--------SLVSPPISLHIF-----MAEVQVSPAGPILENQTVT 343
SD G YTC A N G ++ PP ++ + + A ++ N ++
Sbjct: 2737 ISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPIS 2796
Query: 344 LVCNTPNEAPSDLRYSWYKNHVLLEDAHS-------HTLRLHLATRADTGFYFCEVQNVH 396
L C T P L +WYK+ L + L++ A D G Y C N
Sbjct: 2797 LYCETNAAPPPTL--TWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEA 2854
Query: 397 GSERSGPVSVVVNHPPLTPVLTAFLETQAGLV----GILHCSVVSEPLATLVLSHGGHIL 452
G E S V V PP+ + L + ++ ++ C P G L
Sbjct: 2855 G-EDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPL 2913
Query: 453 ASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR 512
+ DH S N L+I + + TD G Y C A N+ G+A + + +
Sbjct: 2914 L----EDDHHKFLS-----NGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPP 2964
Query: 513 LLISPAAE---VVEGQAVTLSCRSGLSPTPDARFSWY-------LNGALLHEGPGSSLLL 562
+I P +E VV ++L+C P PD SW LN L G +L +
Sbjct: 2965 SVIGPKSENLTVVVNNFISLTCEVSGFPPPD--LSWLKNEQPIKLNTNTLIVPGGRTLQI 3022
Query: 563 PAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLL 622
A +D G Y C A + A LTV PP + L G L
Sbjct: 3023 IRAKVSDGGEYTCIAI--NQAGESKKKFSLTVYVPPSIKDHDSE-SLSVVNVREGTSVSL 3079
Query: 623 LCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLE 682
C ++ PP + R++ S +++ +L ++ +
Sbjct: 3080 ECESNAVPPPVITWYKNGRMITE--------------STHVEILADGQMLHIK--KAEVS 3123
Query: 683 EEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEAN---LTCNVSREAAG-S 738
+ G Y+C A N G + N P + T +N LTC +A G
Sbjct: 3124 DTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTC----DATGIP 3179
Query: 739 PANFSWFRNGV-LWAQGPLETVTL-----LPVAR---TDAALYACRILTEAGAQLSTPVL 789
P +W +N + LE L L +AR +D+ Y C I + +
Sbjct: 3180 PPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTC-IASNMEGKAQKYYF 3238
Query: 790 LSVLYPPD--RPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSH 847
LS+ PP ++ + + + G +C + P L+ G + S
Sbjct: 3239 LSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKD--------GKPIASG 3290
Query: 848 GRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQ 907
+ + AN L + D+G Y C ATN G + ++ V V+P+
Sbjct: 3291 ETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEED-----RIFNLNVYVTPTIRGN 3345
Query: 908 EGQAVVLSCQVHTGV-----PEGT---SYRWYRDGQPLQEST-------SATLRFAAITL 952
+ +A L V T + GT W ++G PL S+ +R +
Sbjct: 3346 KDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQV 3405
Query: 953 TQAGAYHCQAQAPGSA-----TTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRV 1007
+ Y C A + AP ++ S +T+ T + C
Sbjct: 3406 SDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTS------MACIT 3459
Query: 1008 DSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYIC 1067
D P + L G P G H+ V+ + + L++ A ED G Y C
Sbjct: 3460 DGTPAPSMAWLRD-----------GQPLGLD--AHLTVSTHGMVLQLLKAETEDSGKYTC 3506
Query: 1068 EASNTLGQASASADFDAQAVNVQVWPGATVRE--GQLVN----LTCLVWTTHPAQLTYTW 1121
ASN G+ S F + + G+ E +VN LTC+ + PA TW
Sbjct: 3507 IASNEAGE--VSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIA-SGIPAP-KMTW 3562
Query: 1122 YQDGQ--------QRLDAHSI-PLPNVTVRDATSYRCGVGPPG------RAPRLSRPITL 1166
+DG+ Q L + + V D Y C P R+ P +
Sbjct: 3563 MKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNI 3622
Query: 1167 DVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLA-LSHAGRLLASSTAASVPNTLR 1225
PR++ + Q+ L C D+ PP + L + RL A+ +
Sbjct: 3623 AGTDEPRDITVL-----RNRQVTLE-CKSDAVPPPVITWLRNGERLQATPRVRILSGGRY 3676
Query: 1226 LELRGPQPRDEGFYSCSARSPLGQANTSLELRLE-GVRVILAPEAAVPEGAPITV-TCAD 1283
L++ D Y+C A + G+ L + + P++ V TV C
Sbjct: 3677 LQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIA 3736
Query: 1284 PAAHAPTLYTWYHNGRWLQEGPA----ASLSFLVATRAH---AGAYSCQAQDAQGTRSSR 1336
P + TW +G L A FL AH G Y C A +A GT R
Sbjct: 3737 EGVPTPRI-TWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGT-DRR 3794
Query: 1337 PAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHS-- 1394
LQV P A + + C P + +G +L +S
Sbjct: 3795 RIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYR 3854
Query: 1395 -LASGTGHVQVARNALRLQVQDVPAGDD--TYVCTAQNLLGSISTIGRLQVEGARVVAEP 1451
L+SG+ V P+ DD TY CT N G L V+ +A+
Sbjct: 3855 LLSSGS------------LVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADE 3902
Query: 1452 GLD--VPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRL----HAEPVPTLAFTHVARAQ 1505
D V + A ++C G P P + W N RL + + + Q
Sbjct: 3903 PTDFLVTKHAPAVITCTASGVPFP----SIHWTKNGIRLLPRGDGYRILSSGAIEILATQ 3958
Query: 1506 ---AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLA 1562
AG Y C+A G +A V L V PP + +L C P
Sbjct: 3959 LNHAGRYTCVARNAAG-SAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSP 4017
Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
+T V +S H + L++ A+R D G Y+C A N G+A
Sbjct: 4018 FITWQKEGINVNTSGRN--------HAVLPSGGLQIS-RAVR-EDAGTYMCVAQNPAGTA 4067
Score = 133 bits (335), Expect = 1e-30
Identities = 317/1508 (21%), Positives = 545/1508 (36%), Gaps = 254/1508 (16%)
Query: 243 ILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW--------LKDGVRLQTKTGV-LHLP 293
++ P+ + PGE LTC + S+ ++ W L + R++T + L L
Sbjct: 522 VIQVPNNVTVTPGERAVLTCLIISAVDY--NLTWQRNDRDVRLAEPARIRTLANLSLELK 579
Query: 294 QAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPIL-ENQT------VTLVC 346
++DAG Y C + GS + +F+ VQ P ++ +NQ+ V+++C
Sbjct: 580 SVKFNDAGEYHCMVSSEGGSSAAS-----VFLT-VQEPPKVTVMPKNQSFTGGSEVSIMC 633
Query: 347 NTPNEAPSDLRYSWYKNHVLLEDAHSH------TLRLHLATRADTGFYFCEVQNVHGSER 400
+ + +W N + + +H + TL + A D G Y C N G+++
Sbjct: 634 SATGYPKPKI--AWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDK 691
Query: 401 SGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSD 460
+ P L V + L G + ++ C P + GD +
Sbjct: 692 QNSTLRYIEAPKLMVVQSELL-VALGDITVMECKTSGIPPPQVKWF---------KGDLE 741
Query: 461 HSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAE 520
P P L+I++ ++ D+G+Y C A N G AT + + + I A+
Sbjct: 742 LRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPAD 801
Query: 521 VVE--GQAVTLSCRSGLSPTPDAR---------FSWYLNGALLHEGPGSSLLLPAASSTD 569
V G VTL C P P + FS + + + + +L + ++D
Sbjct: 802 VSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASD 861
Query: 570 AGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSD 629
G+Y C A + + +T L P + A G++ L C + +
Sbjct: 862 KGTYICEAENQFGKIQSETTVTVTGLVAP-----LIGISPSVANVIEGQQLTLPCTLLAG 916
Query: 630 PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLC 689
P + K+ + +P + V +L I L++ G Y C
Sbjct: 917 NPIPERRWIKNSAMLLQ-------------NPYITVRSDGSL---HIERVQLQDGGEYTC 960
Query: 690 EASNALG--NASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSP-ANFSWFR 746
ASN G N +TS + T+ + EG L C +A+G+P + W +
Sbjct: 961 VASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPC----KASGNPKPSVIWSK 1016
Query: 747 NGVL-------WAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPP--- 796
G L ++ G ++ ++ ++ Y C AG V L+V P
Sbjct: 1017 KGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAG-YAKRKVQLTVYVRPRVF 1075
Query: 797 --------DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHG 848
D+P ++L G C V S P ++ L++ P P H
Sbjct: 1076 GDQRGLSQDKPVEISVL---AGEEVTLPCEVKSLPPPIITWAKETQLIS----PFSPRH- 1127
Query: 849 RFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR-GAWVQVSPSP-EL 906
S +++ E DSG Y C ATN+ G+ ++ V +Q P ++
Sbjct: 1128 -----TFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKV 1182
Query: 907 QEGQAVVLSCQVH-TGVPEGTSYRWYR-------DGQPLQESTSATLRFAAITLTQAGAY 958
Q GQ V + C T +P T W + DG+ + TL T + AG Y
Sbjct: 1183 QVGQRVDIPCNAQGTPLPVIT---WSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIY 1239
Query: 959 HCQA-QAPGSATTSLAAPISLHVSYAPRHVTL-----TTLMDTGPGRLGLLLCRVDSDPP 1012
C A G+ T I+LHV P L TT + + C P
Sbjct: 1240 TCVATNIAGTDETE----ITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPK 1295
Query: 1013 AQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNT 1072
++ LH R + G+ E + + +V P D G YIC A N
Sbjct: 1296 PTIKWLHNGRELTGREPGISILEDGTLLVIASVTP------------YDNGEYICVAVNE 1343
Query: 1073 LGQASASADFDAQAVNV----QVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQR 1128
G + V + +V QL NL C V T P+ + WY+D Q
Sbjct: 1344 AGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGT-PSPI-IMWYKDNVQV 1401
Query: 1129 LDAHSIPLPN---------VTVRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLT 1178
++ +I N T DA Y C + G + + +DVL P T
Sbjct: 1402 TESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKY---FNIDVLVPP-----T 1453
Query: 1179 YLLESHGGQLALVL-------CTVDSRPPAQLALSHAGR--LLASSTAASVPNTLRLELR 1229
+ + ++++VL C V P + G+ L + L L+
Sbjct: 1454 IIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLK 1513
Query: 1230 GPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVI----LAPEAAVPEGAPITVTCADPA 1285
+ D+G Y C+ + G+ ++L + I + + +V + I + C
Sbjct: 1514 NARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRG 1573
Query: 1286 AHAPTLYTWYHNGRWLQEGPAASL----SFLVATRAH---AGAYSCQAQDAQGTRSSRPA 1338
P + TWY +G+ + A +L RA + Y+C + GT + +
Sbjct: 1574 LPMPAI-TWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGT-AEKSF 1631
Query: 1339 ALQVLYAPQ-DAVLSSFRDSR---ARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHS 1394
+ V P + L++ + + A S+ ++C P L DG + + +
Sbjct: 1632 HVDVYVPPMIEGNLATPLNKQVVIAHSL-TLECKAAGNPSPILTWLKDGVPVKANDNIRI 1690
Query: 1395 LASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLD 1454
A G + + Q++ G Y+C A ++ G + +V+ V+ P ++
Sbjct: 1691 EAGG-------KKLEIMSAQEIDRGQ--YICVATSVAGEKEI--KYEVD---VLVPPAIE 1736
Query: 1455 ---------VPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTH----V 1501
V L L C + G P P T W + + + + +
Sbjct: 1737 GGDETSYFIVMVNNLLELDCHVTGSPPP----TIMWLKDGQLIDERDGFKILLNGRKLVI 1792
Query: 1502 ARAQ---AGMYHCLAELPTGAAASAPVMLRVLYPPK------TPTMMVFVEPEGGLRGIL 1552
A+AQ G+Y C+A T + V PP + ++V +P L
Sbjct: 1793 AQAQVSNTGLYRCMA-ANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVA-----L 1846
Query: 1553 DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612
C + P S+T + QP A+ ++ + +S L++ L D G Y
Sbjct: 1847 QCIANGIPNPSIT------WLKDDQPVNT-AQGNLKIQSSGRVLQIAKTLL--EDAGRYT 1897
Query: 1613 CSASNVLG 1620
C A+N G
Sbjct: 1898 CVATNAAG 1905
Score = 133 bits (334), Expect = 2e-30
Identities = 283/1247 (22%), Positives = 453/1247 (36%), Gaps = 234/1247 (18%)
Query: 213 RILRCQLS-------VANHRA---QSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTC 262
RI+R Q+S VA++RA +LQV +AP + + +L G ++ C
Sbjct: 3399 RIVRAQVSDVAVYTCVASNRAGVDNKHYNLQV-FAPPNMDNSMGTEEITVLKGSSTSMAC 3457
Query: 263 QVNSSYPAVSSIKWLKDG--------VRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSL 314
+ PA S+ WL+DG + + T VL L +A D+G YTC A N G
Sbjct: 3458 -ITDGTPA-PSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGE- 3514
Query: 315 VSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNE---------APSDLRYSWYKNHV 365
+S H + ++ E++ ++++ N P E AP + +W K+
Sbjct: 3515 ----VSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAP---KMTWMKDGR 3567
Query: 366 LLEDAHS-------HTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPV-- 416
L LR+ A DTG Y C + G + + V P +
Sbjct: 3568 PLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDE 3627
Query: 417 ---LTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNS 473
+T Q L C + P + G L +T PR SG
Sbjct: 3628 PRDITVLRNRQV----TLECKSDAVPPPVITWLRNGERLQAT-------PRVRILSGGRY 3676
Query: 474 LRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAA-RLLISPAAEVVE-GQAVTLSC 531
L++ DL +T Y C A+N G T N + P + V+ ++ L C
Sbjct: 3677 LQINNADLGDT--ANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLEC 3734
Query: 532 RSGLSPTPDARFSWYLNGALLHEG-------PGSSLLLPAASSTDAGSYHCRARDGHSAS 584
+ PTP R +W +GA+L L + +A TD G Y C A +
Sbjct: 3735 IAEGVPTP--RITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATN----- 3787
Query: 585 GPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVA 644
AAG R L + S P + V
Sbjct: 3788 --------------------------AAGTDRRRIDLQVHVPPSIAPGPTNM-----TVI 3816
Query: 645 TSLPSGGGCSTCGGCSPRMKVTKAPNLLRVE---------------IHNPLLEEEGLYLC 689
++ + C G P + K +LL V+ I +P +++ Y C
Sbjct: 3817 VNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYEC 3876
Query: 690 EASNALGNASTSATFNGQATV-LAIAPSHTL-QEGTEANLTCNVSREAAGSP-ANFSWFR 746
+N G+ + Q +A P+ L + A +TC A+G P + W +
Sbjct: 3877 TVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCT----ASGVPFPSIHWTK 3932
Query: 747 NGV----------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPP 796
NG+ + + G +E +L A Y C + A V L V PP
Sbjct: 3933 NGIRLLPRGDGYRILSSGAIE---ILATQLNHAGRYTC-VARNAAGSAHRHVTLHVHEPP 3988
Query: 797 DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEA 856
+ L + + L C P + G V + GR A +
Sbjct: 3989 VIQPQPSELHVILNNPILLPCEATGTPSPFITW--------QKEGINVNTSGRNHAVLPS 4040
Query: 857 NSLKLE--VRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSP--SPELQE---- 908
L++ VRE D+G+Y C A N G++ + V QV P SP L+E
Sbjct: 4041 GGLQISRAVRE----DAGTYMCVAQNPAGTALGKIKLNV-----QVPPVISPHLKEYVIA 4091
Query: 909 -GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQES------TSATLRFAAITLTQAGAYHCQ 961
+ + LSC+ G+P W++DG+ + ES +S +L+ A + AG Y C
Sbjct: 4092 VDKPITLSCEAD-GLPP-PDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCM 4149
Query: 962 A-QAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG 1020
A GS++TS +++HV PR + +L C D P +
Sbjct: 4150 AANVAGSSSTS--TKLTVHVP--PRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKD 4205
Query: 1021 DRLVASTL-QGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASAS 1079
+ L+A+ L + P G L + +LED G Y C A+N G+
Sbjct: 4206 NVLLANLLGKYTAEPYGE--------------LILENVVLEDSGFYTCVANNAAGE---- 4247
Query: 1080 ADFDAQAVNVQVWPGAT-------VREGQLVNLTCLVWTTHPAQLTYTWYQD----GQQR 1128
D ++ V V P T + +G+ + L+C +LT+T+ +
Sbjct: 4248 -DTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDS 4306
Query: 1129 LDAHS-IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY---LLESH 1184
++ HS + + V+ D+ +Y C + + I + P + Y +E
Sbjct: 4307 VNGHSELVIERVSKEDSGTYVC---TAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPL 4363
Query: 1185 GGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSAR 1244
GG A++ C V P + + G + S L + G D G Y+C A
Sbjct: 4364 GGN-AILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVAT 4422
Query: 1245 SPLGQANTSLELRLEGVRVI-LAP-EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQ 1302
+ G S+ L L+ +I L P E + G I + C PT+ TW G +
Sbjct: 4423 NEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTI-TWSRQGHSIS 4481
Query: 1303 EGPAA------SLSFLVATRAHAGAYSCQAQDAQGTRSSR-PAALQV 1342
SL A + + C A++ G+ R P +QV
Sbjct: 4482 WDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQV 4528
Score = 124 bits (310), Expect = 1e-27
Identities = 233/1018 (22%), Positives = 361/1018 (35%), Gaps = 170/1018 (16%)
Query: 236 YAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV------ 289
+ P + P +L VTL C+ ++ P V I WL++G RLQ V
Sbjct: 3617 HVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV--ITWLRNGERLQATPRVRILSGG 3674
Query: 290 --LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSP---AGP----ILENQ 340
L + A D YTC A N G F+ V V P GP IL N+
Sbjct: 3675 RYLQINNADLGDTANYTCVASNIAGKTTRE------FILTVNVPPNIKGGPQSLVILLNK 3728
Query: 341 TVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHT-------LRLHLATRADTGFYFCEVQ 393
+ L C E R +W K+ +L H+ L + A DTG Y C
Sbjct: 3729 STVLECIA--EGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMAT 3786
Query: 394 NVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILA 453
N G++R + + V+ PP + + L C P ++ GH+L
Sbjct: 3787 NAAGTDRRR-IDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLN 3845
Query: 454 STSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARL 513
+ + SG+ L I D+ Y+C+ TN G+ T+D
Sbjct: 3846 VDQNQNSYRLLSSGS-------LVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPS 3898
Query: 514 LISPAAE--VVEGQAVTLSCRSGLSPTPDARFSWYLNGA-LLHEGPGSSLL------LPA 564
+ + V + ++C + P P W NG LL G G +L + A
Sbjct: 3899 IADEPTDFLVTKHAPAVITCTASGVPFPSIH--WTKNGIRLLPRGDGYRILSSGAIEILA 3956
Query: 565 ASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLC 624
AG Y C AR+ +A L V PP + L + LL C
Sbjct: 3957 TQLNHAGRYTCVARN--AAGSAHRHVTLHVHEPPVIQPQPSELHVIL-----NNPILLPC 4009
Query: 625 RVDSDPPARLQLLHKDRVVATS------LPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHN 678
P + + V TS LPSGG ++I
Sbjct: 4010 EATGTPSPFITWQKEGINVNTSGRNHAVLPSGG----------------------LQISR 4047
Query: 679 PLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAG- 737
+ E+ G Y+C A N G A N Q V + H + + +S EA G
Sbjct: 4048 AVREDAGTYMCVAQNPAGTALGKIKLNVQ--VPPVISPHLKEYVIAVDKPITLSCEADGL 4105
Query: 738 SPANFSWFRNGV---------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPV 788
P + +W ++G + + G L+ + P DA Y C AG+ ST
Sbjct: 4106 PPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQP---GDAGHYTCMAANVAGSS-STST 4161
Query: 789 LLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHG 848
L+V PP + + A+ C D P + LLA LG
Sbjct: 4162 KLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLG------- 4214
Query: 849 RFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN--TSLFFQVRGAWVQVSPSPEL 906
++ A+ +L + + L DSG Y C A N G SL V + ++ L
Sbjct: 4215 KYTAEPYG---ELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSL 4271
Query: 907 QEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT-----LRFAAITLTQAGAYHCQ 961
+G+ + LSC+ TG+P W + + + L ++ +G Y C
Sbjct: 4272 NKGEQLRLSCKA-TGIPL-PKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCT 4329
Query: 962 AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP-GRLGLLLCRVDSDPPAQLRLLHG 1020
A+ ++ + A ++V P P G +L C V DP ++
Sbjct: 4330 AE---NSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRK 4386
Query: 1021 --DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASA 1078
D ++ ++ +G GS L I+G + ED G Y C A+N G
Sbjct: 4387 GVDIEISHRIRQLGN--GS--------------LAIYGTVNEDAGDYTCVATNEAGVVER 4430
Query: 1079 SADFDAQAVN-VQVWPGATV-REGQLVNLTCLVWTTHPAQLTYTWYQDGQ--------QR 1128
S Q+ + + P TV G + L C T Q T TW + G
Sbjct: 4431 SMSLTLQSPPIITLEPVETVINAGGKIILNC--QATGEPQPTITWSRQGHSISWDDRVNV 4488
Query: 1129 LDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGG 1186
L +S+ + + D + + C ++R + VL +R+ +++ HGG
Sbjct: 4489 LSNNSLYIADAQKEDTSEFEC----------VARNLMGSVL-----VRVPVIVQVHGG 4531
Score = 119 bits (299), Expect = 2e-26
Identities = 186/822 (22%), Positives = 304/822 (36%), Gaps = 99/822 (12%)
Query: 855 EANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR--GAWVQVSPSPELQEGQAV 912
E+ S+ L++ ++ L D G Y C A + G+ FF V +QV + + G+
Sbjct: 478 ESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERA 537
Query: 913 VLSCQVHTGVPEGTSY----RWYRDGQPLQESTSA--TLRFAAITLTQAGAYHCQAQAPG 966
VL+C + + V ++ R R +P + T A +L ++ AG YHC + G
Sbjct: 538 VLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEG 597
Query: 967 SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVAS 1026
S AA + L V P+ + G ++C P ++ D +
Sbjct: 598 G---SSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVG 654
Query: 1027 TLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLG---QASASADFD 1083
+ + +G+ L I A +D G+Y C ASN+ G Q S +
Sbjct: 655 SHRYRMTSDGT--------------LFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIE 700
Query: 1084 AQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQ-DGQQRLDAHSIPLPNVTV- 1141
A + V V V G + + C P Q+ W++ D + R I P + +
Sbjct: 701 APKLMV-VQSELLVALGDITVMECKTSGIPPPQV--KWFKGDLELRPSTFLIIDPLLGLL 757
Query: 1142 -------RDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLC 1193
DA Y C + GRA + ITLDV P ++ + G + C
Sbjct: 758 KIQETQDLDAGDYTCVAINEAGRA---TGKITLDVGSPPVFIQEPADVSMEIGSNVTLPC 814
Query: 1194 TVDSRPPAQLALSHAGRLLASSTAASVPNTLRLE-----LRGPQPRDEGFYSCSARSPLG 1248
V P + + S SV + +L + D+G Y C A + G
Sbjct: 815 YVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFG 874
Query: 1249 QANTSLELRLEGV---RVILAPEAA-VPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEG 1304
+ + + + G+ + ++P A V EG +T+ C A + W N L +
Sbjct: 875 KIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQN 934
Query: 1305 P------AASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSR 1358
P SL G Y+C A + GT +++ ++ V P +
Sbjct: 935 PYITVRSDGSLHIERVQLQDGGEYTCVASNVAGT-NNKTTSVVVHVLPTIQHGQQILSTI 993
Query: 1359 ARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPA 1418
+ C P + S G++++TSS S A G + V P
Sbjct: 994 EGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFS-AGADGSLYVVS----------PG 1042
Query: 1419 GDDT--YVCTAQNLLGSISTIGRLQV----------EGARVVAEPGLDVPEGAALNLSCR 1466
G+++ YVCTA N G +L V G + V G + L C
Sbjct: 1043 GEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCE 1102
Query: 1467 LLGGPGPV---GNSTFAWFWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASA 1523
+ P P+ T R P ++ T + +GMY C+A G A
Sbjct: 1103 VKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQA 1162
Query: 1524 PVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHL-GSRLVASSQPQGAP 1582
V L V PPK ++ + G R + C PL +T GS ++ +
Sbjct: 1163 -VKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGE----- 1216
Query: 1583 AEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSAST 1624
H +++P+ + I+ PSD G Y C A+N+ G+ T
Sbjct: 1217 -----HHVSNPDG-TLSIDQATPSDAGIYTCVATNIAGTDET 1252
Score = 113 bits (283), Expect = 1e-24
Identities = 284/1363 (20%), Positives = 495/1363 (36%), Gaps = 228/1363 (16%)
Query: 367 LEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAG 426
L+++ S L + T +D GFY C + G+ R+ V PP+ V T G
Sbjct: 476 LKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVT-PG 534
Query: 427 LVGILHCSVVSEPLATLVLSHGGHILASTSGDSD---HSPRFSGTSGPNSLRLEIRDLEE 483
+L C L++S + L D D P T +L LE++ ++
Sbjct: 535 ERAVLTC---------LIISAVDYNLTWQRNDRDVRLAEPARIRTLA--NLSLELKSVKF 583
Query: 484 TDSGEYKCSATNSLGNATSTLDFHA-NAARLLISPAAE-VVEGQAVTLSCRSGLSPTPDA 541
D+GEY C ++ G++ +++ ++ + P + G V++ C + P P
Sbjct: 584 NDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKP-- 641
Query: 542 RFSWYLNGALL------HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVL 595
+ +W +N + +L + A+ DAG Y C A +SA + L +
Sbjct: 642 KIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLA--SNSAGTDKQNSTLRYI 699
Query: 596 YPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCST 655
P+ + L + G ++ C+ PP +++ D +
Sbjct: 700 EAPKLMVVQSELLV-----ALGDITVMECKTSGIPPPQVKWFKGDLELRP---------- 744
Query: 656 CGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFN-GQATVLAIA 714
S + + LL+++ L + G Y C A N G A+ T + G V
Sbjct: 745 ----STFLIIDPLLGLLKIQETQDL--DAGDYTCVAINEAGRATGKITLDVGSPPVFIQE 798
Query: 715 PSHTLQE-GTEANLTCNVS---------REAAGSP--------ANFSWFRNGVLWAQGPL 756
P+ E G+ L C V R P ++ S R G L+
Sbjct: 799 PADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALF----- 853
Query: 757 ETVTLLPVARTDAALYACRILTEAG-AQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALF 815
+L + +D Y C + G Q T V ++ L P ++ ++ +G
Sbjct: 854 ----ILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTL 909
Query: 816 ICT-VDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSY 874
CT + P+ +L + V S G L + + L D G Y
Sbjct: 910 PCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDG-----------SLHIERVQLQDGGEY 958
Query: 875 RCEATNVLGSSN--TSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYR 932
C A+NV G++N TS+ V EG V L C+ +G P+ S W +
Sbjct: 959 TCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKA-SGNPK-PSVIWSK 1016
Query: 933 DGQPLQESTS-------ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPR 985
G+ + S++ +L + ++G Y C A T+ A YA R
Sbjct: 1017 KGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTA-------TNTA-------GYAKR 1062
Query: 986 HVTLTTLMDT---GPGRLGLLLCRVDSDPPAQLRLLHGDRL-VASTLQGVGGPEGSSPRL 1041
V LT + G R + D P ++ +L G+ + + ++ + P + +
Sbjct: 1063 KVQLTVYVRPRVFGDQR------GLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKE 1116
Query: 1042 HVAVAPNTLR--------LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWP 1093
++P + R ++I D G+Y+C A+N G + A +NV V P
Sbjct: 1117 TQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVT-----QAVKLNVHVPP 1171
Query: 1094 -------GATVREGQLVNLTCLVWTTHPAQLTY-----TWYQDGQQRLD--AHSIPLPNV 1139
V+ GQ V++ C T +T+ T DG+ + ++ +
Sbjct: 1172 KIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQA 1231
Query: 1140 TVRDATSYRC------GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLC 1193
T DA Y C G + P T++ L P N T E Q C
Sbjct: 1232 TPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYN---TTFQERVANQRIEFPC 1288
Query: 1194 TVDSRPPAQLALSHAGRLLASST--AASVPNTLRLELRGPQPRDEGFYSCSARSPLGQAN 1251
P + H GR L + + + L + P D G Y C A + G
Sbjct: 1289 PAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTE 1348
Query: 1252 TSLELRLEGVRVILAPE----AAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAA 1307
L++ VI E +V + C +P + WY + + E
Sbjct: 1349 RKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSP-IIMWYKDNVQVTESSTI 1407
Query: 1308 S-------LSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR 1360
L AT AG YSC+A + GT S + + VL P + ++F + +
Sbjct: 1408 QTVNNGKILKLFRATPEDAGRYSCKAINIAGT-SQKYFNIDVL-VPPTIIGTNFPNEVSV 1465
Query: 1361 SM---AVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVP 1417
+ ++C V P ++ DGK L G +V++ L +++
Sbjct: 1466 VLNRDVALECQVKGTPFPDIHWFKDGK---------PLFLGDPNVELLDRGQVLHLKNAR 1516
Query: 1418 AGD-DTYVCTAQNLLGSISTIGRL------QVEGARVVAEPGLDVPEGAALNLSCRLLGG 1470
D Y CT N G + +L ++G V + + V + + L C G
Sbjct: 1517 RNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTD--ISVLINSLIKLECETRGL 1574
Query: 1471 PGPVGNSTFAWFWNDRRL----HAEPVPTLAFTHVARAQ---AGMYHCLAELPTGAAASA 1523
P P W+ + + + A + + H+ RAQ + Y C G A
Sbjct: 1575 PMP----AITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTA--- 1627
Query: 1524 PVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQP----- 1578
K+ + V+V P + G L ++ + + + +L L + + P
Sbjct: 1628 ---------EKSFHVDVYVPPM--IEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWL 1676
Query: 1579 -QGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620
G P + + ++ +++I + + D+G+YIC A++V G
Sbjct: 1677 KDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAG 1719
Score = 109 bits (272), Expect = 3e-23
Identities = 213/974 (21%), Positives = 351/974 (36%), Gaps = 134/974 (13%)
Query: 715 PSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGVLWA------QGPLETVTLLPVARTD 768
P + LQ G + C+V P S+ RNGV + + + V +D
Sbjct: 440 PGYYLQPG---QIPCSVDSLL---PFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSD 493
Query: 769 AALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLA 828
Y C ++ AG + V PP ++ + + G A+ C + S A
Sbjct: 494 EGFYECIAVSSAGTGRAQ-TFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIIS------A 546
Query: 829 LFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTS 888
+ + ++ R + A +L LE++ + D+G Y C ++ GSS S
Sbjct: 547 VDYNLTWQRNDRDVRLAEPARIRTLA---NLSLELKSVKFNDAGEYHCMVSSEGGSSAAS 603
Query: 889 LFFQVRGAWVQVSPSPELQE---GQAVVLSCQVHTGVPEGTSYRWYRD-----GQPLQES 940
+F V+ +V+ P+ Q G V + C TG P+ D + +
Sbjct: 604 VFLTVQEP-PKVTVMPKNQSFTGGSEVSIMCSA-TGYPKPKIAWTVNDMFIVGSHRYRMT 661
Query: 941 TSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRL 1000
+ TL AG Y C A SA T ++ AP+ + + + + G +
Sbjct: 662 SDGTLFIKNAAPKDAGIYGCLAS--NSAGTDKQNSTLRYIE-APKLMVVQSELLVALGDI 718
Query: 1001 GLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLE 1060
++ C+ PP Q++ GD + P + + P L+I
Sbjct: 719 TVMECKTSGIPPPQVKWFKGDLELR-------------PSTFLIIDPLLGLLKIQETQDL 765
Query: 1061 DEGVYICEASNTLGQASASADFDAQA--VNVQVWPGATVREGQLVNLTCLVWTTHPAQLT 1118
D G Y C A N G+A+ D + V +Q ++ G V L C V +P + T
Sbjct: 766 DAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYV-QGYP-EPT 823
Query: 1119 YTWYQ-------------DGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPIT 1165
W + +L ++ + N+ D +Y C + +T
Sbjct: 824 IKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVT 883
Query: 1166 LDVLYAPR-NLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTL 1224
+ L AP + + G QL L + P + +L + +V +
Sbjct: 884 VTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDG 943
Query: 1225 RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVP--EGAPITVTCA 1282
L + Q +D G Y+C A + G N + + + + I + + EG P+T+ C
Sbjct: 944 SLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCK 1003
Query: 1283 DPAAHAPTLYTWYHNGRWLQEGPA-------ASLSFLVATRAHAGAYSCQAQDAQGTRSS 1335
P++ W G + A SL + +G Y C A + G +
Sbjct: 1004 ASGNPKPSVI-WSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGY-AK 1061
Query: 1336 RPAALQVLYAPQDAVLSSFRDSRARSM-------------AVIQCTVDSEPPAELALSHD 1382
R L V P+ F D R S + C V S PP + + +
Sbjct: 1062 RKVQLTVYVRPR-----VFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKE 1116
Query: 1383 GKVLATSSGVHS-LASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQ 1441
++++ S H+ L SG+ + R + Y+C A N+ G+++ +L
Sbjct: 1117 TQLISPFSPRHTFLPSGSMKITETRTS----------DSGMYLCVATNIAGNVTQAVKLN 1166
Query: 1442 VEGARVVAE--PGLDVPEGAALNLSCRLLGGPGPV-----GNSTFAWFWNDRRLH-AEPV 1493
V + L V G +++ C G P PV G ST D H + P
Sbjct: 1167 VHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLV---DGEHHVSNPD 1223
Query: 1494 PTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPP-----KTPTMMVFVEPEGGL 1548
TL+ + AG+Y C+A G + + L V PP + P F E
Sbjct: 1224 GTLSIDQATPSDAGIYTCVATNIAGTDETE-ITLHVQEPPTVEDLEPPYNTTFQERVANQ 1282
Query: 1549 RGILDCRVDSEPLASLT-LHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSD 1607
R C P ++ LH G L EP I +L L I ++ P D
Sbjct: 1283 RIEFPCPAKGTPKPTIKWLHNGRELTGR--------EPGISILEDGTLLV--IASVTPYD 1332
Query: 1608 QGEYICSASNVLGS 1621
GEYIC A N G+
Sbjct: 1333 NGEYICVAVNEAGT 1346
Score = 103 bits (258), Expect = 1e-21
Identities = 194/875 (22%), Positives = 315/875 (36%), Gaps = 132/875 (15%)
Query: 118 EISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTE---VDFNCSTPYVCLQEQV--- 171
++ + ++ V + T + T+ P + G + + N ST C+ E V
Sbjct: 3683 DLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTP 3742
Query: 172 RLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIH 231
R+ W+ + G H+++ H+ D GR L C + A + I
Sbjct: 3743 RITWRKDGAVLAGNHARYSILENGFLHIQSAHVT----DTGRYL-CMATNAAGTDRRRID 3797
Query: 232 LQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQT------ 285
LQV P I P+ ++ TL C+ SI W K+G L
Sbjct: 3798 LQVHVPPS---IAPGPTNMTVIVNVQTTLACEATGI--PKPSINWRKNGHLLNVDQNQNS 3852
Query: 286 ----KTGVLHLPQAAWSDAGVYTCQAENGVGS---LVSPPISLHIFMAEVQVSPAGPILE 338
+G L + + D Y C NG G V + + +A+ P ++
Sbjct: 3853 YRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIAD---EPTDFLVT 3909
Query: 339 NQTVTLVCNTPNEAPSDLRYSWYKNHV-LLEDAHSHTLRLH-----LATRAD-TGFYFCE 391
++ T + P + W KN + LL + + LAT+ + G Y C
Sbjct: 3910 KHAPAVITCTASGVPFPSIH-WTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCV 3968
Query: 392 VQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHI 451
+N GS V++ V+ PP+ + L +L C P + G I
Sbjct: 3969 ARNAAGSAHRH-VTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEG-I 4026
Query: 452 LASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAA 511
+TSG +H+ SG L+I D+G Y C A N G A + +
Sbjct: 4027 NVNTSG-RNHAVLPSGG-------LQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVP 4078
Query: 512 RLLISPAAEVVEG--QAVTLSCRSGLSPTPDARFSWYLNGALLHEG------PGSSLLLP 563
++ E V + +TLSC + P PD +W+ +G + E SL +
Sbjct: 4079 PVISPHLKEYVIAVDKPITLSCEADGLPPPD--ITWHKDGRAIVESIRQRVLSSGSLQIA 4136
Query: 564 AASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLL 623
DAG Y C A + A S+ LTV PPR + ++ + +L
Sbjct: 4137 FVQPGDAGHYTCMA--ANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNE-----NSQAILP 4189
Query: 624 CRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEE 683
C D P + KD V+ +L K T P + + N +LE+
Sbjct: 4190 CVADGIPTPAINW-KKDNVLLANLLG--------------KYTAEP-YGELILENVVLED 4233
Query: 684 EGLYLCEASNALG--NASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSP-A 740
G Y C A+NA G + S T + T + +L +G + L+C +A G P
Sbjct: 4234 SGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSC----KATGIPLP 4289
Query: 741 NFSW-FRNGVLWA-----QGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLY 794
+W F N ++ A G E V + V++ D+ Y C G + +
Sbjct: 4290 KLTWTFNNNIIPAHFDSVNGHSELV-IERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEP 4348
Query: 795 PPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKA 854
P + + G A+ C V P + ++ K
Sbjct: 4349 PVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTI---------------------QWNRKG 4387
Query: 855 EANSLKLEVRELGLG----------DSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSP 904
+ +R+LG G D+G Y C ATN G S+ ++ +
Sbjct: 4388 VDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPV 4447
Query: 905 E--LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL 937
E + G ++L+CQ TG P+ T W R G +
Sbjct: 4448 ETVINAGGKIILNCQA-TGEPQPT-ITWSRQGHSI 4480
Score = 97.1 bits (240), Expect = 1e-19
Identities = 178/793 (22%), Positives = 286/793 (36%), Gaps = 127/793 (16%)
Query: 901 SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDG------QPLQESTSATLRFAAITLTQ 954
+P LQ GQ + C V + +P S+ R+G Q L+ES S L A +TL+
Sbjct: 439 TPGYYLQPGQ---IPCSVDSLLPFTLSF--VRNGVTLGVDQYLKESASVNLDIAKVTLSD 493
Query: 955 AGAYHC---QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDP 1011
G Y C + G A T V P +VT+T PG +L C + S
Sbjct: 494 EGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVT------PGERAVLTCLIISAV 547
Query: 1012 PAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASN 1071
L DR V R+ L LE+ D G Y C S+
Sbjct: 548 DYNLTWQRNDRDVRL---------AEPARIRTLA---NLSLELKSVKFNDAGEYHCMVSS 595
Query: 1072 TLGQASASADFDAQ-AVNVQVWP-GATVREGQLVNLTC---------LVWTTHPAQLT-- 1118
G ++AS Q V V P + G V++ C + WT + +
Sbjct: 596 EGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGS 655
Query: 1119 --YTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLR 1176
Y DG ++ + N +DA Y C + + TL + AP+ +
Sbjct: 656 HRYRMTSDG-------TLFIKNAAPKDAGIYGCLASNSAGTDKQNS--TLRYIEAPKLMV 706
Query: 1177 LTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTL-RLELRGPQPRD 1235
+ L G + ++ C PP Q+ L ST + L L+++ Q D
Sbjct: 707 VQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLD 766
Query: 1236 EGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE--GAPITVTCADPAAHAPTLYT 1293
G Y+C A + G+A + L + V + A V G+ +T+ C PT+
Sbjct: 767 AGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTI-K 825
Query: 1294 WYHNGRWLQEGPAASLSFLVAT---------------RAHAGAYSCQAQDAQG-TRSSRP 1337
W R L P S F V++ + G Y C+A++ G +S
Sbjct: 826 W----RRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETT 881
Query: 1338 AALQVLYAPQDAVLSSFRDSRARSMAVIQCT-VDSEPPAELALSHDGKVLATSSGVHSLA 1396
+ L AP + S + + CT + P E + +L + + +
Sbjct: 882 VTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRS 941
Query: 1397 SGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV--AEPGLD 1454
G+ H++ R+Q+QD Y C A N+ G+ + + V + + L
Sbjct: 942 DGSLHIE------RVQLQD----GGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILS 991
Query: 1455 VPEGAALNLSCRLLGGPGPVGNSTFAWFWNDR---------RLHAEPVPTLAFTHVARAQ 1505
EG + L C+ G P P + W+ + + A +L +
Sbjct: 992 TIEGIPVTLPCKASGNPKP------SVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEE 1045
Query: 1506 AGMYHCLAELPTGAAASAPVMLRVLYPPK--------TPTMMVFVEPEGGLRGILDCRVD 1557
+G Y C A T A V L V P+ + V + G L C V
Sbjct: 1046 SGEYVCTA-TNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVK 1104
Query: 1558 SEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASN 1617
S P +T ++L++ P+ H +++ I R SD G Y+C A+N
Sbjct: 1105 SLPPPIITWAKETQLISPFSPR--------HTFLPSGSMK--ITETRTSDSGMYLCVATN 1154
Query: 1618 VLGSASTSTYFGV 1630
+ G+ + + V
Sbjct: 1155 IAGNVTQAVKLNV 1167
Score = 71.6 bits (174), Expect = 6e-12
Identities = 113/461 (24%), Positives = 163/461 (35%), Gaps = 44/461 (9%)
Query: 1193 CTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSP--LGQA 1250
C+VDS P L+ G L ++ L++ DEGFY C A S G+A
Sbjct: 451 CSVDSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRA 510
Query: 1251 NTSLELRLEGVRVILAP-EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAA-- 1307
T ++ E VI P V G +TC +A L TW N R ++ A
Sbjct: 511 QTFFDVS-EPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNL-TWQRNDRDVRLAEPARI 568
Query: 1308 ------SLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARS 1361
SL AG Y C ++G S+ L V P+ V+ + S
Sbjct: 569 RTLANLSLELKSVKFNDAGEYHCMV-SSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGS 627
Query: 1362 MAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD 1421
I C+ P ++A + + + S + GT ++ A P
Sbjct: 628 EVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNA----------APKDAG 677
Query: 1422 TYVCTAQNLLGSISTIGRLQ-VEGAR-VVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTF 1479
Y C A N G+ L+ +E + +V + L V G + C+ G P P
Sbjct: 678 IYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPP----QV 733
Query: 1480 AWFWNDRRLHAEPV----PTLAFTHVARAQ---AGMYHCLAELPTGAAASAPVMLRVLYP 1532
WF D L P L + Q AG Y C+A + A+ + L V P
Sbjct: 734 KWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVA-INEAGRATGKITLDVGSP 792
Query: 1533 PKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLAS 1592
P V E G L C V P ++ + S+P + + A
Sbjct: 793 PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGA- 851
Query: 1593 PNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRAL 1633
+ I L SD+G YIC A N G + T V L
Sbjct: 852 -----LFILNLWASDKGTYICEAENQFGKIQSETTVTVTGL 887
Score = 70.9 bits (172), Expect = 1e-11
Identities = 130/552 (23%), Positives = 212/552 (38%), Gaps = 85/552 (15%)
Query: 1133 SIPLPNVTVRDATSYRC------GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGG 1186
++ + VT+ D Y C G G +S P V+ P N+ +T G
Sbjct: 483 NLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPP--VIQVPNNVTVT------PG 534
Query: 1187 QLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPN--TLRLELRGPQPRDEGFYSCSAR 1244
+ A++ C + S L R + + A + L LEL+ + D G Y C
Sbjct: 535 ERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVS 594
Query: 1245 SPLGQANTSLELRL-EGVRVILAPE-AAVPEGAPITVTCADPAAHAPTLYTWY------- 1295
S G + S+ L + E +V + P+ + G+ +++ C+ P + W
Sbjct: 595 SEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKI-AWTVNDMFIV 653
Query: 1296 --HNGRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSS 1353
H R +G +L A AG Y C A ++ GT + + L+ + AP+ V+ S
Sbjct: 654 GSHRYRMTSDG---TLFIKNAAPKDAGIYGCLASNSAGT-DKQNSTLRYIEAPKLMVVQS 709
Query: 1354 FRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQ- 1412
+ V++C PP ++ L S+ + + L++Q
Sbjct: 710 ELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLI--------IDPLLGLLKIQE 761
Query: 1413 VQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPE--GAALNLSCRLLGG 1470
QD+ AGD Y C A N G + L V V + DV G+ + L C + G
Sbjct: 762 TQDLDAGD--YTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGY 819
Query: 1471 PGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQA---------------GMYHCLAEL 1515
P P T W RRL P+ + F+ + +Q G Y C AE
Sbjct: 820 PEP----TIKW----RRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAEN 871
Query: 1516 PTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLA-SLTLHLGSRLVA 1574
G S T T+ V P G+ + ++ + L TL G+ +
Sbjct: 872 QFGKIQSET----------TVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPE 921
Query: 1575 SSQPQGAPA---EPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
+ + P+I V + + + IE ++ D GEY C ASNV G+ + +T V
Sbjct: 922 RRWIKNSAMLLQNPYITVRSDGS---LHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVH 978
Query: 1632 ALHRLHQFQQLL 1643
L + QQ+L
Sbjct: 979 VLPTIQHGQQIL 990
Score = 58.2 bits (139), Expect = 7e-08
Identities = 98/425 (23%), Positives = 165/425 (38%), Gaps = 63/425 (14%)
Query: 99 NLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDF 158
+L + +QP D+G Y ++ S T +TV PR+ + + E ++
Sbjct: 4132 SLQIAFVQPGDAGHYTC---MAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAIL 4188
Query: 159 NCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQ 218
C + + W+ + + EP G LE + + +D G C
Sbjct: 4189 PCVADGI---PTPAINWKKDNVLLANLLGKYTAEPYGELILENVVL----EDSG-FYTC- 4239
Query: 219 LSVANHRAQSEIH---LQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIK 275
VAN+ A + H L V P ++ P ++ GE + L+C+ + +
Sbjct: 4240 --VANNAAGEDTHTVSLTVHVLPTFTEL---PGDVSLNKGEQLRLSCKATGI--PLPKLT 4292
Query: 276 WLKDG----VRLQTKTG--VLHLPQAAWSDAGVYTCQAENGVGSLVS--------PPISL 321
W + + G L + + + D+G Y C AEN VG + + PP+
Sbjct: 4293 WTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPV-- 4350
Query: 322 HIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH------SHTL 375
F + + P+ N L C + ++ W + V +E +H + +L
Sbjct: 4351 --FKGDYPSNWIEPLGGN--AILNCEVKGDPTPTIQ--WNRKGVDIEISHRIRQLGNGSL 4404
Query: 376 RLHLATRADTGFYFCEVQNVHGS-ERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCS 434
++ D G Y C N G ERS +S+ + PP+ + AG IL+C
Sbjct: 4405 AIYGTVNEDAGDYTCVATNEAGVVERS--MSLTLQSPPIITLEPVETVINAGGKIILNCQ 4462
Query: 435 VVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSAT 494
EP T+ S GH S S D D S S L I D ++ D+ E++C A
Sbjct: 4463 ATGEPQPTITWSRQGH---SISWD-DRVNVLSNNS------LYIADAQKEDTSEFECVAR 4512
Query: 495 NSLGN 499
N +G+
Sbjct: 4513 NLMGS 4517
>gi|11225258 myelin associated glycoprotein isoform a precursor
[Homo sapiens]
Length = 626
Score = 143 bits (361), Expect = 1e-33
Identities = 111/422 (26%), Positives = 200/422 (47%), Gaps = 26/422 (6%)
Query: 4 LPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYD- 62
LP ++ S G WG P + +G+C+ IPC F FP ++ P + +WY++
Sbjct: 7 LPLFWIMISASRGGH--WGAWMPSSISAFEGTCVSIPCRFDFPDELR-PAVVHGVWYFNS 63
Query: 63 -YSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISE 121
Y V + ++V F+GR+ +G+ R C LLL ++ PE G Y FR ++
Sbjct: 64 PYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGG 123
Query: 122 VNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPA 181
N+++ + +++ + P I P E++ GTEV+ +C P C + + L W G +
Sbjct: 124 YNQYTFSEHSVLDIV---NTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180
Query: 182 RSVTFNSQKFEPTGVG-HLETLHMAMSWQDHGRILRCQLSVANHRAQSE--IHLQVKYAP 238
+ E G + LH + + +G L CQ S N Q E + VKY P
Sbjct: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240
Query: 239 KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ---TKTGVLHLPQA 295
V++ S + G V+L C +S+ P + + W++DG L+ ++ +L L +
Sbjct: 241 VIVEM---NSSVEAIEGSHVSLLCGADSNPPPL--LTWMRDGTVLREAVAESLLLELEEV 295
Query: 296 AWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPI--LENQTVTLVCNTPNEAP 353
++ GVY C AEN G + + L + A + + G + +E +TV+++C+T + P
Sbjct: 296 TPAEDGVYACLAENAYGQ-DNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSN-P 353
Query: 354 SDLRYSWYKNHVLLEDAHSHTLRLHL--ATRADTGFYFCEVQNVHGSERSGPVSVVVNHP 411
+ + + +L + L+L L + D G Y+C +N +G +R+ ++ V
Sbjct: 354 DPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYG-QRATAFNLSVEFA 412
Query: 412 PL 413
P+
Sbjct: 413 PV 414
Score = 61.6 bits (148), Expect = 6e-09
Identities = 51/218 (23%), Positives = 89/218 (40%), Gaps = 18/218 (8%)
Query: 328 VQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHL--ATRADT 385
V+++ + +E V+L+C + P L +W ++ +L +A + +L L L T A+
Sbjct: 243 VEMNSSVEAIEGSHVSLLCGADSNPPPLL--TWMRDGTVLREAVAESLLLELEEVTPAED 300
Query: 386 GFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVL 445
G Y C +N +G + V + V + P P + + G + CS S P L +
Sbjct: 301 GVYACLAENAYGQDNR-TVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTI 359
Query: 446 SHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD 505
IL++ +S+ L+LE+ + D GEY C A N G + +
Sbjct: 360 FKEKQILSTVIYESE-------------LQLELPAVSPEDDGEYWCVAENQYGQRATAFN 406
Query: 506 FHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARF 543
A +L+ + V C +P P F
Sbjct: 407 LSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444
Score = 59.7 bits (143), Expect = 2e-08
Identities = 64/237 (27%), Positives = 99/237 (41%), Gaps = 34/237 (14%)
Query: 1056 GAMLEDEGVYI-------------------CEAS--NTLGQASASADFDAQAVNVQVWPG 1094
G + EDEG ++ C+AS NT Q A D + V V
Sbjct: 187 GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN 246
Query: 1095 ATVR--EGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS----IPLPNVTVRDATSYR 1148
++V EG V+L C + P LT W +DG +A + + L VT + Y
Sbjct: 247 SSVEAIEGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGVYA 304
Query: 1149 CGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHA 1208
C + +R + L V+YAP + + + G+ +LC+ S P L +
Sbjct: 305 CLA--ENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKE 362
Query: 1209 GRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265
++L++ S L+LEL P D+G Y C A + GQ T+ L +E V+L
Sbjct: 363 KQILSTVIYES---ELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416
Score = 59.3 bits (142), Expect = 3e-08
Identities = 95/388 (24%), Positives = 150/388 (38%), Gaps = 59/388 (15%)
Query: 1298 GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRP-AALQVLYAPQDAVLSSFRD 1356
G W+Q + L F+ A+ CQA T A++ V Y P ++S +
Sbjct: 194 GTWVQ---VSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250
Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416
+ S + C DS PP L DG VL + +L L++++V
Sbjct: 251 AIEGSHVSLLCGADSNPPPLLTWMRDGTVLR---------------EAVAESLLLELEEV 295
Query: 1417 -PAGDDTYVCTAQNLLGSISTIGRLQVEGA--RVVAEPGLDVPEGAALNLSCRLLGGPGP 1473
PA D Y C A+N G + L V A + + EG +++ C P P
Sbjct: 296 TPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDP 355
Query: 1474 VGNSTFAWFWNDRRLHA----EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRV 1529
+ + ++++ + E L V+ G Y C+AE G A+A L V
Sbjct: 356 I-----LTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATA-FNLSV 409
Query: 1530 LYPPKTPTMMVFVEPEGGLRGILDCR--VDSEPLASLTLHLGSR--LVASSQPQGAPAEP 1585
+ P +++ R + C V S P S+ L SR V S+ + +E
Sbjct: 410 EFAP----VLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSER 465
Query: 1586 HIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWV 1645
VL S LR +A IC+A N+ G+ S F + HR L+W
Sbjct: 466 SGLVLTSILTLRGQAQA-----PPRVICTARNLYGAKSLELPF--QGAHR------LMWA 512
Query: 1646 ----LGLLVGLLLLLLGLGACYTWRRRR 1669
+G +V +L+ + CY + RR
Sbjct: 513 KIGPVGAVVAFAILIAIV--CYITQTRR 538
Score = 58.9 bits (141), Expect = 4e-08
Identities = 58/249 (23%), Positives = 98/249 (39%), Gaps = 22/249 (8%)
Query: 721 EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLL--PVARTDAALYACRILT 778
EG+ +L C + P +W R+G + + E++ L V + +YAC +
Sbjct: 253 EGSHVSLLCGAD---SNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYAC-LAE 308
Query: 779 EAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLAT 838
A Q + V LSV+Y P +P ++ + +G +C+ S P +L +F + +L+T
Sbjct: 309 NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILST 368
Query: 839 SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV 898
+ + L+LE+ + D G Y C A N G T+ V A V
Sbjct: 369 VI--------------YESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414
Query: 899 QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATL--RFAAITLTQAG 956
+ S V C V + ++ + ES + + + LT
Sbjct: 415 LLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSIL 474
Query: 957 AYHCQAQAP 965
QAQAP
Sbjct: 475 TLRGQAQAP 483
Score = 57.4 bits (137), Expect = 1e-07
Identities = 58/249 (23%), Positives = 95/249 (38%), Gaps = 37/249 (14%)
Query: 898 VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST--SATLRFAAITLTQA 955
V+++ S E EG V L C + P + W RDG L+E+ S L +T +
Sbjct: 243 VEMNSSVEAIEGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAED 300
Query: 956 GAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQL 1015
G Y C A+ +A + L V YAP T+ M G +LC S+P L
Sbjct: 301 GVYACLAE---NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPIL 357
Query: 1016 RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQ 1075
+ +++++ + + L+LE+ ED+G Y C A N GQ
Sbjct: 358 TIFKEKQILSTVIY-----------------ESELQLELPAVSPEDDGEYWCVAENQYGQ 400
Query: 1076 ASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIP 1135
+ + + + V + V C+V + + A +P
Sbjct: 401 RATAFNLSVEFAPVLLLESHCAAARDTVQCLCVV-------------KSNPEPSVAFELP 447
Query: 1136 LPNVTVRDA 1144
NVTV ++
Sbjct: 448 SRNVTVNES 456
Score = 55.1 bits (131), Expect = 6e-07
Identities = 52/228 (22%), Positives = 90/228 (39%), Gaps = 31/228 (13%)
Query: 515 ISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDA--GS 572
++ + E +EG V+L C + +P P +W +G +L E SLLL T A G
Sbjct: 245 MNSSVEAIEGSHVSLLCGADSNPPP--LLTWMRDGTVLREAVAESLLLELEEVTPAEDGV 302
Query: 573 YHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPA 632
Y C A + + + L+V+Y P +PT + A G +LC S+P
Sbjct: 303 YACLAENAYGQD--NRTVGLSVMYAPWKPTVNGTM-----VAVEGETVSILCSTQSNPDP 355
Query: 633 RLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEAS 692
L + + ++++T + + L++E+ E++G Y C A
Sbjct: 356 ILTIFKEKQILSTVI--------------------YESELQLELPAVSPEDDGEYWCVAE 395
Query: 693 NALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740
N G +T+ + + + + SH C V S A
Sbjct: 396 NQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVA 443
Score = 54.3 bits (129), Expect = 1e-06
Identities = 95/398 (23%), Positives = 144/398 (36%), Gaps = 70/398 (17%)
Query: 904 PELQEGQAVVLSCQVHTGVPE-GTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYH--- 959
PE+ G V +SC V PE W + + LR T Q H
Sbjct: 147 PEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVP 206
Query: 960 ----------CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDS 1009
CQA P + T S+ V Y P V + + ++ G LLC DS
Sbjct: 207 TREANGHRLGCQASFPNT-TLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADS 265
Query: 1010 DPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA 1069
+PP L + +G+ R VA +L LE+ ++GVY C A
Sbjct: 266 NPPPLLTWMR---------------DGTVLREAVA---ESLLLELEEVTPAEDGVYACLA 307
Query: 1070 SNTLGQASASADFDAQAVNVQVWPGATV--REGQLVNLTC--------LVWTTHPAQLTY 1119
N GQ + + + T+ EG+ V++ C ++ Q+
Sbjct: 308 ENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILS 367
Query: 1120 TWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY 1179
T + + +L+ LP V+ D Y C + + + L V +AP
Sbjct: 368 TVIYESELQLE-----LPAVSPEDDGEYWCVA--ENQYGQRATAFNLSVEFAP-----VL 415
Query: 1180 LLESH---GGQLALVLCTVDSRPPAQLA---------LSHAGRLLASSTAASVPNTLRLE 1227
LLESH LC V S P +A ++ + R S + + T L
Sbjct: 416 LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILT 475
Query: 1228 LRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265
LRG Q + C+AR+ G SLEL +G ++
Sbjct: 476 LRG-QAQAPPRVICTARNLYGA--KSLELPFQGAHRLM 510
Score = 47.8 bits (112), Expect = 9e-05
Identities = 44/182 (24%), Positives = 71/182 (39%), Gaps = 19/182 (10%)
Query: 402 GPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDH 461
G S+ V +PP+ + + +E G L C S P L G +L +
Sbjct: 230 GYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAE--- 286
Query: 462 SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAA--RLLISPAA 519
SL LE+ ++ + G Y C A N+ G T+ A + ++
Sbjct: 287 -----------SLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTM 335
Query: 520 EVVEGQAVTLSCRSGLSPTPDARF--SWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRA 577
VEG+ V++ C + +P P + +++E L LPA S D G Y C A
Sbjct: 336 VAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE-LQLELPAVSPEDDGEYWCVA 394
Query: 578 RD 579
+
Sbjct: 395 EN 396
Score = 45.8 bits (107), Expect = 4e-04
Identities = 63/282 (22%), Positives = 100/282 (35%), Gaps = 39/282 (13%)
Query: 722 GTEANLTCNV--------------SREAAGSPANFSWFRNGV-LWAQGPLETVTLLPVAR 766
GTE ++C V E G PA R W Q L + +P
Sbjct: 152 GTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSL--LHFVPTRE 209
Query: 767 TDAALYACRI-LTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLA 825
+ C+ Q + V YPP ++++ ++ +G +C DS P
Sbjct: 210 ANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPP 269
Query: 826 LLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSS 885
LL G +A A SL LE+ E+ + G Y C A N G
Sbjct: 270 LLTWMR---------------DGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD 314
Query: 886 NTSLFFQVRGA-W-VQVSPSPELQEGQAVVLSCQVHTGV-PEGTSYRWYRDGQPLQESTS 942
N ++ V A W V+ + EG+ V + C + P T ++ + + +
Sbjct: 315 NRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE 374
Query: 943 ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAP 984
L A++ G Y C A+ + A +L V +AP
Sbjct: 375 LQLELPAVSPEDDGEYWCVAE---NQYGQRATAFNLSVEFAP 413
>gi|18104957 myelin associated glycoprotein isoform b precursor
[Homo sapiens]
Length = 582
Score = 143 bits (361), Expect = 1e-33
Identities = 111/422 (26%), Positives = 200/422 (47%), Gaps = 26/422 (6%)
Query: 4 LPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYD- 62
LP ++ S G WG P + +G+C+ IPC F FP ++ P + +WY++
Sbjct: 7 LPLFWIMISASRGGH--WGAWMPSSISAFEGTCVSIPCRFDFPDELR-PAVVHGVWYFNS 63
Query: 63 -YSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISE 121
Y V + ++V F+GR+ +G+ R C LLL ++ PE G Y FR ++
Sbjct: 64 PYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGG 123
Query: 122 VNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPA 181
N+++ + +++ + P I P E++ GTEV+ +C P C + + L W G +
Sbjct: 124 YNQYTFSEHSVLDIV---NTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180
Query: 182 RSVTFNSQKFEPTGVG-HLETLHMAMSWQDHGRILRCQLSVANHRAQSE--IHLQVKYAP 238
+ E G + LH + + +G L CQ S N Q E + VKY P
Sbjct: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240
Query: 239 KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ---TKTGVLHLPQA 295
V++ S + G V+L C +S+ P + + W++DG L+ ++ +L L +
Sbjct: 241 VIVEM---NSSVEAIEGSHVSLLCGADSNPPPL--LTWMRDGTVLREAVAESLLLELEEV 295
Query: 296 AWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPI--LENQTVTLVCNTPNEAP 353
++ GVY C AEN G + + L + A + + G + +E +TV+++C+T + P
Sbjct: 296 TPAEDGVYACLAENAYGQ-DNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSN-P 353
Query: 354 SDLRYSWYKNHVLLEDAHSHTLRLHL--ATRADTGFYFCEVQNVHGSERSGPVSVVVNHP 411
+ + + +L + L+L L + D G Y+C +N +G +R+ ++ V
Sbjct: 354 DPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYG-QRATAFNLSVEFA 412
Query: 412 PL 413
P+
Sbjct: 413 PV 414
Score = 61.6 bits (148), Expect = 6e-09
Identities = 51/218 (23%), Positives = 89/218 (40%), Gaps = 18/218 (8%)
Query: 328 VQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHL--ATRADT 385
V+++ + +E V+L+C + P L +W ++ +L +A + +L L L T A+
Sbjct: 243 VEMNSSVEAIEGSHVSLLCGADSNPPPLL--TWMRDGTVLREAVAESLLLELEEVTPAED 300
Query: 386 GFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVL 445
G Y C +N +G + V + V + P P + + G + CS S P L +
Sbjct: 301 GVYACLAENAYGQDNR-TVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTI 359
Query: 446 SHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD 505
IL++ +S+ L+LE+ + D GEY C A N G + +
Sbjct: 360 FKEKQILSTVIYESE-------------LQLELPAVSPEDDGEYWCVAENQYGQRATAFN 406
Query: 506 FHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARF 543
A +L+ + V C +P P F
Sbjct: 407 LSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444
Score = 59.7 bits (143), Expect = 2e-08
Identities = 64/237 (27%), Positives = 99/237 (41%), Gaps = 34/237 (14%)
Query: 1056 GAMLEDEGVYI-------------------CEAS--NTLGQASASADFDAQAVNVQVWPG 1094
G + EDEG ++ C+AS NT Q A D + V V
Sbjct: 187 GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN 246
Query: 1095 ATVR--EGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS----IPLPNVTVRDATSYR 1148
++V EG V+L C + P LT W +DG +A + + L VT + Y
Sbjct: 247 SSVEAIEGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGVYA 304
Query: 1149 CGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHA 1208
C + +R + L V+YAP + + + G+ +LC+ S P L +
Sbjct: 305 CLA--ENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKE 362
Query: 1209 GRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265
++L++ S L+LEL P D+G Y C A + GQ T+ L +E V+L
Sbjct: 363 KQILSTVIYES---ELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416
Score = 59.3 bits (142), Expect = 3e-08
Identities = 95/388 (24%), Positives = 150/388 (38%), Gaps = 59/388 (15%)
Query: 1298 GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRP-AALQVLYAPQDAVLSSFRD 1356
G W+Q + L F+ A+ CQA T A++ V Y P ++S +
Sbjct: 194 GTWVQ---VSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250
Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416
+ S + C DS PP L DG VL + +L L++++V
Sbjct: 251 AIEGSHVSLLCGADSNPPPLLTWMRDGTVLR---------------EAVAESLLLELEEV 295
Query: 1417 -PAGDDTYVCTAQNLLGSISTIGRLQVEGA--RVVAEPGLDVPEGAALNLSCRLLGGPGP 1473
PA D Y C A+N G + L V A + + EG +++ C P P
Sbjct: 296 TPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDP 355
Query: 1474 VGNSTFAWFWNDRRLHA----EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRV 1529
+ + ++++ + E L V+ G Y C+AE G A+A L V
Sbjct: 356 I-----LTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATA-FNLSV 409
Query: 1530 LYPPKTPTMMVFVEPEGGLRGILDCR--VDSEPLASLTLHLGSR--LVASSQPQGAPAEP 1585
+ P +++ R + C V S P S+ L SR V S+ + +E
Sbjct: 410 EFAP----VLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSER 465
Query: 1586 HIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWV 1645
VL S LR +A IC+A N+ G+ S F + HR L+W
Sbjct: 466 SGLVLTSILTLRGQAQA-----PPRVICTARNLYGAKSLELPF--QGAHR------LMWA 512
Query: 1646 ----LGLLVGLLLLLLGLGACYTWRRRR 1669
+G +V +L+ + CY + RR
Sbjct: 513 KIGPVGAVVAFAILIAIV--CYITQTRR 538
Score = 58.9 bits (141), Expect = 4e-08
Identities = 58/249 (23%), Positives = 98/249 (39%), Gaps = 22/249 (8%)
Query: 721 EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLL--PVARTDAALYACRILT 778
EG+ +L C + P +W R+G + + E++ L V + +YAC +
Sbjct: 253 EGSHVSLLCGAD---SNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYAC-LAE 308
Query: 779 EAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLAT 838
A Q + V LSV+Y P +P ++ + +G +C+ S P +L +F + +L+T
Sbjct: 309 NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILST 368
Query: 839 SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV 898
+ + L+LE+ + D G Y C A N G T+ V A V
Sbjct: 369 VI--------------YESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414
Query: 899 QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATL--RFAAITLTQAG 956
+ S V C V + ++ + ES + + + LT
Sbjct: 415 LLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSIL 474
Query: 957 AYHCQAQAP 965
QAQAP
Sbjct: 475 TLRGQAQAP 483
Score = 57.4 bits (137), Expect = 1e-07
Identities = 58/249 (23%), Positives = 95/249 (38%), Gaps = 37/249 (14%)
Query: 898 VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST--SATLRFAAITLTQA 955
V+++ S E EG V L C + P + W RDG L+E+ S L +T +
Sbjct: 243 VEMNSSVEAIEGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAED 300
Query: 956 GAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQL 1015
G Y C A+ +A + L V YAP T+ M G +LC S+P L
Sbjct: 301 GVYACLAE---NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPIL 357
Query: 1016 RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQ 1075
+ +++++ + + L+LE+ ED+G Y C A N GQ
Sbjct: 358 TIFKEKQILSTVIY-----------------ESELQLELPAVSPEDDGEYWCVAENQYGQ 400
Query: 1076 ASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIP 1135
+ + + + V + V C+V + + A +P
Sbjct: 401 RATAFNLSVEFAPVLLLESHCAAARDTVQCLCVV-------------KSNPEPSVAFELP 447
Query: 1136 LPNVTVRDA 1144
NVTV ++
Sbjct: 448 SRNVTVNES 456
Score = 55.1 bits (131), Expect = 6e-07
Identities = 52/228 (22%), Positives = 90/228 (39%), Gaps = 31/228 (13%)
Query: 515 ISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDA--GS 572
++ + E +EG V+L C + +P P +W +G +L E SLLL T A G
Sbjct: 245 MNSSVEAIEGSHVSLLCGADSNPPP--LLTWMRDGTVLREAVAESLLLELEEVTPAEDGV 302
Query: 573 YHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPA 632
Y C A + + + L+V+Y P +PT + A G +LC S+P
Sbjct: 303 YACLAENAYGQD--NRTVGLSVMYAPWKPTVNGTM-----VAVEGETVSILCSTQSNPDP 355
Query: 633 RLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEAS 692
L + + ++++T + + L++E+ E++G Y C A
Sbjct: 356 ILTIFKEKQILSTVI--------------------YESELQLELPAVSPEDDGEYWCVAE 395
Query: 693 NALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740
N G +T+ + + + + SH C V S A
Sbjct: 396 NQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVA 443
Score = 54.3 bits (129), Expect = 1e-06
Identities = 95/398 (23%), Positives = 144/398 (36%), Gaps = 70/398 (17%)
Query: 904 PELQEGQAVVLSCQVHTGVPE-GTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYH--- 959
PE+ G V +SC V PE W + + LR T Q H
Sbjct: 147 PEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVP 206
Query: 960 ----------CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDS 1009
CQA P + T S+ V Y P V + + ++ G LLC DS
Sbjct: 207 TREANGHRLGCQASFPNT-TLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADS 265
Query: 1010 DPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA 1069
+PP L + +G+ R VA +L LE+ ++GVY C A
Sbjct: 266 NPPPLLTWMR---------------DGTVLREAVA---ESLLLELEEVTPAEDGVYACLA 307
Query: 1070 SNTLGQASASADFDAQAVNVQVWPGATV--REGQLVNLTC--------LVWTTHPAQLTY 1119
N GQ + + + T+ EG+ V++ C ++ Q+
Sbjct: 308 ENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILS 367
Query: 1120 TWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY 1179
T + + +L+ LP V+ D Y C + + + L V +AP
Sbjct: 368 TVIYESELQLE-----LPAVSPEDDGEYWCVA--ENQYGQRATAFNLSVEFAP-----VL 415
Query: 1180 LLESH---GGQLALVLCTVDSRPPAQLA---------LSHAGRLLASSTAASVPNTLRLE 1227
LLESH LC V S P +A ++ + R S + + T L
Sbjct: 416 LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILT 475
Query: 1228 LRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265
LRG Q + C+AR+ G SLEL +G ++
Sbjct: 476 LRG-QAQAPPRVICTARNLYGA--KSLELPFQGAHRLM 510
Score = 47.8 bits (112), Expect = 9e-05
Identities = 44/182 (24%), Positives = 71/182 (39%), Gaps = 19/182 (10%)
Query: 402 GPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDH 461
G S+ V +PP+ + + +E G L C S P L G +L +
Sbjct: 230 GYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAE--- 286
Query: 462 SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAA--RLLISPAA 519
SL LE+ ++ + G Y C A N+ G T+ A + ++
Sbjct: 287 -----------SLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTM 335
Query: 520 EVVEGQAVTLSCRSGLSPTPDARF--SWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRA 577
VEG+ V++ C + +P P + +++E L LPA S D G Y C A
Sbjct: 336 VAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE-LQLELPAVSPEDDGEYWCVA 394
Query: 578 RD 579
+
Sbjct: 395 EN 396
Score = 45.8 bits (107), Expect = 4e-04
Identities = 63/282 (22%), Positives = 100/282 (35%), Gaps = 39/282 (13%)
Query: 722 GTEANLTCNV--------------SREAAGSPANFSWFRNGV-LWAQGPLETVTLLPVAR 766
GTE ++C V E G PA R W Q L + +P
Sbjct: 152 GTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSL--LHFVPTRE 209
Query: 767 TDAALYACRI-LTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLA 825
+ C+ Q + V YPP ++++ ++ +G +C DS P
Sbjct: 210 ANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPP 269
Query: 826 LLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSS 885
LL G +A A SL LE+ E+ + G Y C A N G
Sbjct: 270 LLTWMR---------------DGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD 314
Query: 886 NTSLFFQVRGA-W-VQVSPSPELQEGQAVVLSCQVHTGV-PEGTSYRWYRDGQPLQESTS 942
N ++ V A W V+ + EG+ V + C + P T ++ + + +
Sbjct: 315 NRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE 374
Query: 943 ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAP 984
L A++ G Y C A+ + A +L V +AP
Sbjct: 375 LQLELPAVSPEDDGEYWCVAE---NQYGQRATAFNLSVEFAP 413
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 134 bits (338), Expect = 6e-31
Identities = 180/727 (24%), Positives = 267/727 (36%), Gaps = 97/727 (13%)
Query: 855 EANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPE--LQEGQAV 912
E+ + E+ + G+Y C A + G+ V Q+ P+P + G+
Sbjct: 358 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETA 417
Query: 913 VLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITL-------TQAGAYHCQAQAP 965
VLSC+V P + W RD + L ST + A ++L T G Y C A
Sbjct: 418 VLSCRVLGEAPYNLT--WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA 475
Query: 966 GSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVA 1025
T A + L V AP+ T+ G + C P + + +
Sbjct: 476 NGVT---RASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ 532
Query: 1026 STLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF--- 1082
R+HV L I G ED G Y C+A+N +G +
Sbjct: 533 -----------EDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 578
Query: 1083 ---DAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRL------DAHS 1133
AVN V V G+ L C P ++ WY+ G + + +
Sbjct: 579 DPPSVSAVNAVV----LVAVGEEAVLVCEASGVPPPRV--IWYRGGLEMILAPEGSSSGK 632
Query: 1134 IPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVL 1192
+ +P RDA +Y C V G A S I L V +AP+ L + G+ AL+
Sbjct: 633 LRIPAAQERDAGTYTCRAVNELGDA---SAEIQLAVGHAPQLTELPRDVTVELGRSALLA 689
Query: 1193 CTVDSRPPAQLALSHAG------RLLASSTAAS-VPNTLRLELRGPQPRDEGFYSCSARS 1245
C RPP + RL A + S P++ L P D+ Y C AR+
Sbjct: 690 CRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN 749
Query: 1246 PLGQANTSLELRLEGVR----VILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWL 1301
G+ L + G AP V EG P+++ C A W +GR L
Sbjct: 750 VFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPL 809
Query: 1302 QEGPA------ASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR 1355
G SL A + HAG YSC A + G++ R L V P+ ++
Sbjct: 810 PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQ-HRDVELVVQVPPRIHPTATHH 868
Query: 1356 DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQD 1415
+ A + C P + + + L TS G H S G + +A+ + QD
Sbjct: 869 ITNEGVPASLPCVASGVPAPTITWTKETNAL-TSRGPHYNVSKEGTLLIAQPS----AQD 923
Query: 1416 VPAGDDTYVCTAQNLLG--------SISTIGRLQVEGARVVAEP-GLDVPEGAALNLSCR 1466
A YVCTA N +G S++T R+ + G+R P + G + L C
Sbjct: 924 AGA----YVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCE 979
Query: 1467 LLGGPGPVGNSTFAWFWNDR-------RLHAEPVPTLAFTHVARAQAGMYHCLAELPTGA 1519
G P P+ W + R R P +L V +G Y C A P G+
Sbjct: 980 AKGSPPPL----VTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGS 1035
Query: 1520 AASAPVM 1526
A+ V+
Sbjct: 1036 ASHRYVL 1042
Score = 127 bits (319), Expect = 9e-29
Identities = 173/702 (24%), Positives = 253/702 (36%), Gaps = 83/702 (11%)
Query: 683 EEGLYLCEASN--ALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740
EEG Y C A + G A L AP+ T+ G A L+C V EA P
Sbjct: 373 EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA---PY 429
Query: 741 NFSWFRNGVLWAQGPLETVTLLPVAR----------TDAALYACRILTEAGAQLSTPVLL 790
N +W R+ W P T + +A TD Y C + + A V L
Sbjct: 430 NLTWVRD---WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQC-VASNANGVTRASVWL 485
Query: 791 SVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRF 850
V P ++ QG C+ P H+ + + R
Sbjct: 486 LVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTP--------HISWSRESQALQEDSRI 537
Query: 851 QAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN--TSLFFQVRGAWVQVSPSPELQE 908
A+ L ++ + D+G+Y C+ATN +G+ +L++ + V+ +
Sbjct: 538 HVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAV 594
Query: 909 GQAVVLSCQVHTGVPEGTSYRWYRDGQPL----QESTSATLRFAAITLTQAGAYHCQAQA 964
G+ VL C+ +GVP WYR G + + S+S LR A AG Y C+A
Sbjct: 595 GEEAVLVCEA-SGVPPPRVI-WYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAV- 651
Query: 965 PGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLV 1024
+ +A I L V +AP+ L + GR LL CR PP + GD
Sbjct: 652 --NELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQP 709
Query: 1025 ASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF-- 1082
G G GS R P++ L ED+ Y+CEA N G+ A A
Sbjct: 710 LGLRLGAG--RGSRSR-----QPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762
Query: 1083 --DAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ---------RLDA 1131
A P V EGQ V+L C+V P + W +DG+ R D
Sbjct: 763 TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH-WLKDGRPLPPGSRHSIRADG 821
Query: 1132 HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPR-NLRLTYLLESHGGQLAL 1190
S+ L A Y C A R + L V PR + T+ + + G +L
Sbjct: 822 -SLHLDRALQEHAGRYSCVA--TNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASL 878
Query: 1191 VLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLG-- 1248
P L + +V L + P +D G Y C+A + +G
Sbjct: 879 PCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFS 938
Query: 1249 ------QANTSLELRLEGVRVILAP-EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWL 1301
NT + + G R P + G +T+ C + P L TW + R +
Sbjct: 939 SQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDC-EAKGSPPPLVTWTKDSRPV 997
Query: 1302 QE-------GPAASLSFLVATRAHAGAYSCQAQDAQGTRSSR 1336
P+ SL +G Y C A + G+ S R
Sbjct: 998 PPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHR 1039
Score = 112 bits (279), Expect = 4e-24
Identities = 164/667 (24%), Positives = 246/667 (36%), Gaps = 72/667 (10%)
Query: 1002 LLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061
L+ C V S P +L+L G+ + H + N+ EI A +
Sbjct: 328 LVSCSVHSALPFRLQLRRGEARLGE-------------ERHFQESGNS-SWEILRASKAE 373
Query: 1062 EGVYICEASNTLGQASASADFDAQAVNVQVWPG--ATVREGQLVNLTCLVWTTHPAQLTY 1119
EG Y C A + G A A Q+ P TV G+ L+C V P LT
Sbjct: 374 EGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT- 432
Query: 1120 TWYQDGQ---------QRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLY 1170
W +D + +L S+ + + D Y+C R S + L V
Sbjct: 433 -WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS--VWLLVRE 489
Query: 1171 APRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRG 1230
AP+ T G V C+ P ++ S + L + V L ++G
Sbjct: 490 APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQG 549
Query: 1231 PQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAA--VPEGAPITVTCADPAAHA 1288
P D G YSC A + +G ++ L + A A V G + C + +
Sbjct: 550 VAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC-EASGVP 608
Query: 1289 PTLYTWYHNGRWLQEGPAAS----LSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLY 1344
P WY G + P S L A AG Y+C+A + G S+ L V +
Sbjct: 609 PPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE-IQLAVGH 667
Query: 1345 APQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSH-DGKVLATSSGVHSLASGTGHVQ 1403
APQ L A++ C PP + DG+ L L +G G
Sbjct: 668 APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL-----RLGAGRGSRS 722
Query: 1404 VARNALRLQVQDV-PAGDDTYVCTAQNLLGSISTIGRLQVEGAR----VVAEPGLDVPEG 1458
++ L + V P YVC A+N+ G + RL V G + P + V EG
Sbjct: 723 RQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEG 782
Query: 1459 AALNLSCRLLGG-PGPVGNSTFAWFWNDRRL---HAEPVPTLAFTHVARA---QAGMYHC 1511
++L C +L G P P + W + R L + H+ RA AG Y C
Sbjct: 783 QPVSLPCIVLAGRPLPERH----WLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSC 838
Query: 1512 LAELPTGAAASAPVMLRVLYPPKT-PTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGS 1570
+A T + V L V PP+ PT + E G+ L C P ++T +
Sbjct: 839 VA-TNTAGSQHRDVELVVQVPPRIHPTATHHITNE-GVPASLPCVASGVPAPTITWTKET 896
Query: 1571 RLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGV 1630
+ S P ++ ++A P+A D G Y+C+A+N +G +S V
Sbjct: 897 NALTSRGPHYNVSKEGTLLIAQPSA----------QDAGAYVCTATNTVGFSSQEMRLSV 946
Query: 1631 RALHRLH 1637
R+H
Sbjct: 947 NTKPRIH 953
Score = 107 bits (267), Expect = 1e-22
Identities = 166/625 (26%), Positives = 229/625 (36%), Gaps = 105/625 (16%)
Query: 210 DHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYP 269
D GR +C S AN ++ + L V+ AP+ + + S ++ G V ++C S YP
Sbjct: 464 DGGRY-QCVASNANGVTRASVWLLVREAPQ---VSIHTSSQHFSQGVEVKVSCSA-SGYP 518
Query: 270 AVSSIKWLKDGVRLQTKT-------GVLHLPQAAWSDAGVYTCQAENGVGS-------LV 315
I W ++ LQ + G L + A DAG Y+CQA N VG+
Sbjct: 519 T-PHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY 577
Query: 316 SPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLL----EDAH 371
+ P S+ A V V+ + LVC P R WY+ + + E +
Sbjct: 578 TDPPSVSAVNAVVLVAVG------EEAVLVCEASGVPPP--RVIWYRGGLEMILAPEGSS 629
Query: 372 SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGIL 431
S LR+ A D G Y C N G + S + + V H P L + + G +L
Sbjct: 630 SGKLRIPAAQERDAGTYTCRAVNELG-DASAEIQLAVGHAPQLTELPRDVTVELGRSALL 688
Query: 432 HCSVVSEPLATLVLSHG-GHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYK 490
C P T+ G G L G + R S + P+S L + D Y
Sbjct: 689 ACRATGRPPPTVTWRRGDGQPLGLRLG----AGRGSRSRQPDSGVLFFESVAPEDQAPYV 744
Query: 491 CSATNSLGN----ATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWY 546
C A N G A + HA +P V+EGQ V+L C L+ P W
Sbjct: 745 CEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIV-LAGRPLPERHWL 803
Query: 547 LNGALLHEGP------GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPR- 599
+G L G SL L A AG Y C A + +A L V PPR
Sbjct: 804 KDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATN--TAGSQHRDVELVVQVPPRI 861
Query: 600 QPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGC 659
PT T + + A L C V S PA K+ TS
Sbjct: 862 HPTATHHITNEGVPAS------LPC-VASGVPAPTITWTKETNALTSR------------ 902
Query: 660 SPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG----------NASTSATFNGQAT 709
P V+K LL I P ++ G Y+C A+N +G N NG
Sbjct: 903 GPHYNVSKEGTLL---IAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRN 959
Query: 710 VLAIAPSHTLQEGTEANLTCNVSREAAGSPANF-SWF-----------RNGVLWAQGPLE 757
+ T + G E L C EA GSP +W R G+L P
Sbjct: 960 A-NVPLQVTAKAGEEVTLDC----EAKGSPPPLVTWTKDSRPVPPITNRYGLL----PSG 1010
Query: 758 TVTLLPVARTDAALYACRILTEAGA 782
++ L V D+ Y C AG+
Sbjct: 1011 SLRLAQVQVGDSGHYECTASNPAGS 1035
Score = 105 bits (263), Expect = 3e-22
Identities = 182/747 (24%), Positives = 279/747 (37%), Gaps = 97/747 (12%)
Query: 761 LLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVD 820
+L ++ + Y C ++ AG + ++ V PP + + + + G A+ C V
Sbjct: 366 ILRASKAEEGTYECTAVSRAGTGRAKAQIV-VTDPPPQLVPAPNVTVSPGETAVLSCRVL 424
Query: 821 SRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATN 880
L +L S G A+ L LE+ + D G Y+C A+N
Sbjct: 425 GEAPYNLTWVRDWRVLPASTG----------RVAQLADLSLEISGIIPTDGGRYQCVASN 474
Query: 881 VLGSSNTSLFFQVRGAWVQVS---PSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL 937
G + S++ VR A QVS S +G V +SC +G P W R+ Q L
Sbjct: 475 ANGVTRASVWLLVREA-PQVSIHTSSQHFSQGVEVKVSCSA-SGYPT-PHISWSRESQAL 531
Query: 938 QEST------SATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTT 991
QE + TL + AG Y CQA + + ++L+ + P +
Sbjct: 532 QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQAT---NEVGTDQETVTLYYTDPPSVSAVNA 588
Query: 992 LMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLR 1051
++ G +L+C PP ++ G L+ + PEGSS +
Sbjct: 589 VVLVAVGEEAVLVCEASGVPPPRVIWYRGG------LEMILAPEGSSSG----------K 632
Query: 1052 LEIHGAMLEDEGVYICEASNTLGQASASADFDA-QAVNVQVWP-GATVREGQLVNLTCLV 1109
L I A D G Y C A N LG ASA A + P TV G+ L C
Sbjct: 633 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRA 692
Query: 1110 WTTHPAQLTYTWYQ-DGQ--------------QRLDAHSIPLPNVTVRDATSYRCGVGPP 1154
P T TW + DGQ ++ D+ + +V D Y C
Sbjct: 693 TGRPPP--TVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNV 750
Query: 1155 -GRAPRLSRPITLDVLYAPRNLRLTY----LLESHGGQLALVLCTVDSRPPAQLALSHAG 1209
G+ +R I +AP + + +LE G ++L + RP + G
Sbjct: 751 FGKVQAEARLIVTG--HAPPQIASSAPTVRVLE--GQPVSLPCIVLAGRPLPERHWLKDG 806
Query: 1210 RLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEA 1269
R L + S+ L L G YSC A + G + +EL ++ V + P A
Sbjct: 807 RPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ-VPPRIHPTA 865
Query: 1270 A---VPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLS----FLVA--TRAHAG 1320
EG P ++ C APT+ GP ++S L+A + AG
Sbjct: 866 THHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAG 925
Query: 1321 AYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR-------DSRARSMAVIQCTVDSEP 1373
AY C A + G SS+ L V P+ + S ++A + C P
Sbjct: 926 AYVCTATNTVGF-SSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSP 984
Query: 1374 PAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGS 1433
P + + D + + + + L +G +++A QVQ +G Y CTA N GS
Sbjct: 985 PPLVTWTKDSRPVPPITNRYGLLP-SGSLRLA------QVQVGDSGH--YECTASNPAGS 1035
Query: 1434 ISTIGRLQVEGARVVAEPGLDVPEGAA 1460
S L V+G L VP A
Sbjct: 1036 ASHRYVLGVQGRTSWQPQSLPVPHHPA 1062
Score = 96.7 bits (239), Expect = 2e-19
Identities = 173/738 (23%), Positives = 260/738 (35%), Gaps = 109/738 (14%)
Query: 380 ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEP 439
A++A+ G Y C + G+ R+ +VV PP V + G +L C V+ E
Sbjct: 369 ASKAEEGTYECTAVSRAGTGRA-KAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA 427
Query: 440 LATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG- 498
L +L +++G + L LEI + TD G Y+C A+N+ G
Sbjct: 428 PYNLTWVRDWRVLPASTG---------RVAQLADLSLEISGIIPTDGGRYQCVASNANGV 478
Query: 499 NATSTLDFHANAARLLISPAAE-VVEGQAVTLSCRSGLSPTPDARFSWYLNGALL----- 552
S A ++ I +++ +G V +SC + PTP SW L
Sbjct: 479 TRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTP--HISWSRESQALQEDSR 536
Query: 553 -HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDA 611
H +L++ + DAG+Y C+A + G V P + + L A
Sbjct: 537 IHVDAQGTLIIQGVAPEDAGNYSCQAT---NEVGTDQETVTLYYTDPPSVSAVNAVVLVA 593
Query: 612 AGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNL 671
G A +L+C PP R+ + ++ + P G S ++++ A
Sbjct: 594 VGEEA----VLVCEASGVPPPRV-IWYRGGLEMILAPEGSS-------SGKLRIPAAQE- 640
Query: 672 LRVEIHNPLLEEEGLYLCEASNALGNASTSATFN-GQATVLAIAPSH-TLQEGTEANLTC 729
+ G Y C A N LG+AS G A L P T++ G A L C
Sbjct: 641 ----------RDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLAC 690
Query: 730 NVSREAAGSPANFSWFR-------------NGVLWAQGPLETVTLLPVARTDAALYACRI 776
R P +W R G Q + VA D A Y C
Sbjct: 691 ---RATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEA 747
Query: 777 LTEAG-AQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTV-DSRPLALLALFHGEH 834
G Q ++++ PP + + + +G C V RPL H
Sbjct: 748 RNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLP------ERH 801
Query: 835 LLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSS--NTSLFFQ 892
L G +P R +A+ + L + +G Y C ATN GS + L Q
Sbjct: 802 WLKD--GRPLPPGSRHSIRADGS---LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ 856
Query: 893 VRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRD-------GQPLQESTSATL 945
V + EG L C V +GVP T W ++ G S TL
Sbjct: 857 VPPRIHPTATHHITNEGVPASLPC-VASGVPAPT-ITWTKETNALTSRGPHYNVSKEGTL 914
Query: 946 RFAAITLTQAGAYHCQA-QAPGSATTSLAAPIS----LHVSYAPRHVTLTTLMDTGPGRL 1000
A + AGAY C A G ++ + ++ +H++ R+ + + G
Sbjct: 915 LIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMN-GSRNANVPLQVTAKAGEE 973
Query: 1001 GLLLCRVDSDPPAQLRLLHGDRLVASTLQGVG-GPEGSSPRLHVAVAPNTLRLEIHGAML 1059
L C PP + R V G P GS L + +
Sbjct: 974 VTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGS--------------LRLAQVQV 1019
Query: 1060 EDEGVYICEASNTLGQAS 1077
D G Y C ASN G AS
Sbjct: 1020 GDSGHYECTASNPAGSAS 1037
Score = 90.9 bits (224), Expect = 1e-17
Identities = 185/796 (23%), Positives = 281/796 (35%), Gaps = 150/796 (18%)
Query: 252 ILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTG--------VLHLPQAAWSDAGVY 303
+ PGE L+C+V P ++ W++D L TG L + +D G Y
Sbjct: 411 VSPGETAVLSCRVLGEAPY--NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRY 468
Query: 304 TCQAENGVGSL---------VSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPS 354
C A N G +P +S+H + + + V + C+
Sbjct: 469 QCVASNANGVTRASVWLLVREAPQVSIH--------TSSQHFSQGVEVKVSCSASGYPTP 520
Query: 355 DLRYSWYKNHVLLEDAHSH-----TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVN 409
+ +S ++ L ED+ H TL + D G Y C+ N G+++ V++
Sbjct: 521 HISWS-RESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQE-TVTLYYT 578
Query: 410 HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGG--HILASTSGDSDHSPRFSG 467
PP + A + G +L C P ++ GG ILA
Sbjct: 579 DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP------------- 625
Query: 468 TSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFH-ANAARLLISPAAEVVE-GQ 525
G +S +L I +E D+G Y C A N LG+A++ + +A +L P VE G+
Sbjct: 626 -EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGR 684
Query: 526 AVTLSCRSGLSPTPDA---RFSWYLNGALLHEGPGSS--------LLLPAASSTDAGSYH 574
+ L+CR+ P P R G L G GS L + + D Y
Sbjct: 685 SALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYV 744
Query: 575 CRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARL 634
C AR+ + ++T PP+ + G+ L C V + P
Sbjct: 745 CEARNVFGKVQAEARLIVTGHAPPQIAS-----SAPTVRVLEGQPVSLPCIVLAGRPLPE 799
Query: 635 QLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNA 694
+ KD LP G S S + + L E G Y C A+N
Sbjct: 800 RHWLKD---GRPLPPGSRHSIRADGS-------------LHLDRALQEHAGRYSCVATNT 843
Query: 695 LGNASTSATFNGQA--TVLAIAPSHTLQEGTEANLTCNVSREAAGSPA-NFSWFR-NGVL 750
G+ Q + A H EG A+L C A+G PA +W + L
Sbjct: 844 AGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPC----VASGVPAPTITWTKETNAL 899
Query: 751 WAQGPLETV----TLL---PVARTDAALYACRILTEAGAQLSTPVLLSVLYPP------- 796
++GP V TLL P A+ DA Y C G S + LSV P
Sbjct: 900 TSRGPHYNVSKEGTLLIAQPSAQ-DAGAYVCTATNTVGFS-SQEMRLSVNTKPRIHMNGS 957
Query: 797 DRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEA 856
+ + G C P L+ P P R+
Sbjct: 958 RNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSR-------PVPPITNRYGLLPSG 1010
Query: 857 NSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRG--AWVQVSPSPELQEGQAVVL 914
+ L + ++ +GDSG Y C A+N GS++ V+G +W Q L
Sbjct: 1011 S---LRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSW------------QPQSL 1055
Query: 915 SCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQ------AGAYHCQAQAPGSA 968
H G S PL + T ++R ++L A C +QA S+
Sbjct: 1056 PVPHHPACLSGLSV-------PLLQPTPRSVRLCHLSLRAPLPPPFATPTSCLSQACLSS 1108
Query: 969 TTSLAAPISLHVSYAP 984
+T +SLH+S P
Sbjct: 1109 ST-----LSLHLSPYP 1119
Score = 89.4 bits (220), Expect = 3e-17
Identities = 171/772 (22%), Positives = 273/772 (35%), Gaps = 101/772 (13%)
Query: 910 QAVVLSCQVHTGVPEGTSYRWYR----DGQPLQESTSATLRFAAITLTQAGAYHCQAQAP 965
Q +++SC VH+ +P R + + QES +++ + + G Y C A +
Sbjct: 325 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSR 384
Query: 966 GSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVA 1025
+ A + V+ P + + PG +L CRV + P L + R++
Sbjct: 385 AGTGRAKAQIV---VTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL- 440
Query: 1026 STLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADF--- 1082
P + +A L LEI G + D G Y C ASN G AS
Sbjct: 441 --------PASTGRVAQLA----DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR 488
Query: 1083 DAQAVNVQVWPGATVREGQLVNLTC---------LVWTTHPAQLTYTWYQDGQQRLDAH- 1132
+A V++ +G V ++C + W+ L +D + +DA
Sbjct: 489 EAPQVSIHT-SSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ----EDSRIHVDAQG 543
Query: 1133 SIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVL 1192
++ + V DA +Y C +TL P + ++ G+ A+++
Sbjct: 544 TLIIQGVAPEDAGNYSCQA--TNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 601
Query: 1193 CTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANT 1252
C PP ++ G + + S LR+ Q RD G Y+C A + LG A+
Sbjct: 602 CEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIP--AAQERDAGTYTCRAVNELGDASA 659
Query: 1253 SLELRLEGVRVI--LAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN------------- 1297
++L + + L + V G + C PT+ TW
Sbjct: 660 EIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTV-TWRRGDGQPLGLRLGAGR 718
Query: 1298 GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSS--FR 1355
G ++ + L F Y C+A++ G + + +AP S+ R
Sbjct: 719 GSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVR 778
Query: 1356 DSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQD 1415
+ +++ + P E DG+ L S A G+ H+ A LQ
Sbjct: 779 VLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRA-----LQEH- 832
Query: 1416 VPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLD--VPEGAALNLSCRLLGGPGP 1473
AG Y C A N GS L V+ + EG +L C G P P
Sbjct: 833 --AG--RYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP 888
Query: 1474 VGNSTFAWFWNDRRL-------HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVM 1526
T W L + TL + AG Y C A G + S +
Sbjct: 889 ----TITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFS-SQEMR 943
Query: 1527 LRVLYPPK-------TPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQ 1579
L V P+ + + V + G LDC P +T SR V
Sbjct: 944 LSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPV------ 997
Query: 1580 GAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
P + + L +LR + ++ D G Y C+ASN GSAS GV+
Sbjct: 998 --PPITNRYGLLPSGSLR--LAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045
Score = 85.1 bits (209), Expect = 5e-16
Identities = 128/523 (24%), Positives = 198/523 (37%), Gaps = 83/523 (15%)
Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159
L+++ + PED+G+Y+ + +EV +D + + T+ P V + + V + G E
Sbjct: 545 LIIQGVAPEDAGNYSCQ-ATNEVG--TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 601
Query: 160 CSTPYVCLQEQVRLQWQGQDPARSVTFNS---QKFEPTGVGHLETLHMAMSWQDHGRILR 216
C G P R + + P G + A +D G
Sbjct: 602 CEA-------------SGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYT- 647
Query: 217 CQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW 276
C+ A +EI L V +AP+ ++ P + G L C+ P ++ W
Sbjct: 648 CRAVNELGDASAEIQLAVGHAPQLTEL---PRDVTVELGRSALLACRATGRPPP--TVTW 702
Query: 277 LKD-----GVRL---------QTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLH 322
+ G+RL Q +GVL A D Y C+A N G + + +
Sbjct: 703 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762
Query: 323 IFMAEVQVSPAGP---ILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLR--- 376
A Q++ + P +LE Q V+L C P R+ W K+ L H++R
Sbjct: 763 TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH-WLKDGRPLPPGSRHSIRADG 821
Query: 377 -LHL--ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHC 433
LHL A + G Y C N GS+ VV P + P T + T G+ L C
Sbjct: 822 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHI-TNEGVPASLPC 880
Query: 434 SVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSA 493
P T+ + + L TS ++ GT L I D+G Y C+A
Sbjct: 881 VASGVPAPTITWTKETNAL--TSRGPHYNVSKEGT-------LLIAQPSAQDAGAYVCTA 931
Query: 494 TNSLGNATSTL--------DFHANAARLLISPAAEVVE-GQAVTLSCRSGLSPTPDARFS 544
TN++G ++ + H N +R P + G+ VTL C + SP P +
Sbjct: 932 TNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPP--LVT 989
Query: 545 WYLNG----------ALLHEGPGSSLLLPAASSTDAGSYHCRA 577
W + LL P SL L D+G Y C A
Sbjct: 990 WTKDSRPVPPITNRYGLL---PSGSLRLAQVQVGDSGHYECTA 1029
Score = 47.8 bits (112), Expect = 9e-05
Identities = 78/315 (24%), Positives = 118/315 (37%), Gaps = 52/315 (16%)
Query: 217 CQLSVANHRAQSEIHLQVK-YAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIK 275
C+ + Q+E L V +AP +I S +L G+ V+L C V + P +
Sbjct: 745 CEARNVFGKVQAEARLIVTGHAPP--QIASSAPTVRVLEGQPVSLPCIVLAGRP-LPERH 801
Query: 276 WLKDGVRLQTKT-------GVLHLPQAAWSDAGVYTCQAENGVGS-------LVSPPISL 321
WLKDG L + G LHL +A AG Y+C A N GS +V P +
Sbjct: 802 WLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI 861
Query: 322 HIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH-----TLR 376
H + P +L C + ++ N + H + TL
Sbjct: 862 HPTATHHITNEGVP------ASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLL 915
Query: 377 LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPV-------LTAFLETQAGLVG 429
+ + D G Y C N G S + + VN P + + + +AG
Sbjct: 916 IAQPSAQDAGAYVCTATNTVGFS-SQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEV 974
Query: 430 ILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSG---PNSLRLEIRDLEETDS 486
L C P L + + DS P + G SLRL ++ DS
Sbjct: 975 TLDCEAKGSPPP----------LVTWTKDSRPVPPITNRYGLLPSGSLRL--AQVQVGDS 1022
Query: 487 GEYKCSATNSLGNAT 501
G Y+C+A+N G+A+
Sbjct: 1023 GHYECTASNPAGSAS 1037
Score = 40.4 bits (93), Expect = 0.015
Identities = 87/393 (22%), Positives = 136/393 (34%), Gaps = 60/393 (15%)
Query: 40 PCIFSFPADVEVPDGITAIWYYDYSGQRQ--VVSHSADPKLVEARF-RGRTEFMGNPEHR 96
P + P DV V G +A+ +G+ V D + + R GR P+
Sbjct: 669 PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG 728
Query: 97 VCNLLLKDLQPEDSGSYNFRFEISEV-NRWSDVKGT---LVTVTEEPRVPTIASPVELLE 152
V L + + PED Y + E N + V+ +VT P++ + A V +LE
Sbjct: 729 V--LFFESVAPEDQAPY-----VCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLE 781
Query: 153 GTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHL----ETLHMAMSW 208
G V C + G+ + P G H +LH+ +
Sbjct: 782 GQPVSLPC------------IVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRAL 829
Query: 209 QDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSY 268
Q+H C + ++ L V+ P+ + P+ + + E V + +S
Sbjct: 830 QEHAGRYSCVATNTAGSQHRDVELVVQVPPR-----IHPTATHHITNEGVPASLPCVASG 884
Query: 269 PAVSSIKWLKDGVRLQT--------KTGVLHLPQAAWSDAGVYTCQAENGVG-------- 312
+I W K+ L + K G L + Q + DAG Y C A N VG
Sbjct: 885 VPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRL 944
Query: 313 SLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLED--- 369
S+ + P V + VTL C P +W K+ +
Sbjct: 945 SVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPP--LVTWTKDSRPVPPITN 1002
Query: 370 ----AHSHTLRLHLATRADTGFYFCEVQNVHGS 398
S +LRL D+G Y C N GS
Sbjct: 1003 RYGLLPSGSLRLAQVQVGDSGHYECTASNPAGS 1035
>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform a [Homo sapiens]
Length = 6620
Score = 119 bits (297), Expect = 3e-26
Identities = 374/1644 (22%), Positives = 572/1644 (34%), Gaps = 315/1644 (19%)
Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159
L++ D+ PED+G Y E V V +T+ + +E+LEG F
Sbjct: 2703 LVVHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKT------MEVLEGESCSFE 2756
Query: 160 CSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHM-AMSWQDHGRILRCQ 218
C + + G+ +S +F+ T G L + + D G ++
Sbjct: 2757 CVLSHESASDPAMWTVGGK-----TVGSSSRFQATRQGRKYILVVREAAPSDAGEVV--- 2808
Query: 219 LSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLK 278
SV S+ L V+ P I+ + + PGE V L C+++ A + + WLK
Sbjct: 2809 FSVRG--LTSKASLIVRERP--AAIIKPLEDQWVAPGEDVELRCELSR---AGTPVHWLK 2861
Query: 279 D--GVRLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHI----- 323
D +R K V L + A+ DAG YTC+ E + SLH+
Sbjct: 2862 DRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKST-----ASLHVEEKAN 2916
Query: 324 ----FMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH------ 373
+ +QV G T C T + A + +W K + L + H
Sbjct: 2917 CFTEELTNLQVEEKG------TAVFTCKTEHPAAT---VTWRKGLLELRASGKHQPSQEG 2967
Query: 374 -TLRLHLAT--RADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGI 430
TLRL ++ +AD+ Y C++ G +S +V ++ Q G
Sbjct: 2968 LTLRLTISALEKADSDTYTCDI----GQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSAT 3023
Query: 431 LHCSVVS---EPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
C + EP+ + H A+ + D P G + L L R L DSG
Sbjct: 3024 FRCRISPANYEPVHWFLDKTPLH--ANELNEIDAQP-----GGYHVLTL--RQLALKDSG 3074
Query: 488 EYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYL 547
A + +A + + ++ A + EG+ +TL C + T D W
Sbjct: 3075 TIYFEAGDQRASAALRVTEKPSVFSRELTDAT-ITEGEDLTLVCETS---TCDIPVCWTK 3130
Query: 548 NGALL---------HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
+G L HEG + LL+ A+ D+G Y C A G S +++ V
Sbjct: 3131 DGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKC------EAGGACSSSIVRV--HA 3182
Query: 599 RQPTFTTRL-DLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCG 657
R F L DL+ GA L C V S A ++ + + V+
Sbjct: 3183 RPVRFQEALKDLEVLEGGA---ATLRC-VLSSVAAPVKWCYGNNVLRP------------ 3226
Query: 658 GCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNG---QATVLAIA 714
+ + + +L + + N ++ G Y C + G+ +TSAT A +
Sbjct: 3227 --GDKYSLRQEGAMLELVVRNLRPQDSGRYSC----SFGDQTTSATLTVTALPAQFIGKL 3280
Query: 715 PSHTLQEGTEANLTCNVSREAAGSPANFS-WFRNG---VLWAQGPLETVTLLPVARTDAA 770
+ EG A L C +S+ A S R+G L G + + + +A DAA
Sbjct: 3281 RNKEATEGATATLRCELSKAAPVEWRKGSETLRDGDRYCLRQDGAMCELQIRGLAMVDAA 3340
Query: 771 LYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALF 830
Y+C G + ++ L P + +G A C + A +
Sbjct: 3341 EYSC----VCGEERTSASLTIRPMPAHFIGRLRHQESIEGATATLRCELSK--AAPVEWR 3394
Query: 831 HGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLF 890
G L R + + +L++ L + D+G Y C V G TS
Sbjct: 3395 KGRESLRDG--------DRHSLRQDGAVCELQICGLAVADAGEYSC----VCGEERTSAT 3442
Query: 891 FQVR---GAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRW------YRDGQPL---Q 938
V+ + + + E EG +L C++ P W RDG Q
Sbjct: 3443 LTVKALPAKFTEGLRNEEAVEGATAMLWCELSKVAP----VEWRKGPENLRDGDRYILRQ 3498
Query: 939 ESTSATLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP 997
E T L+ + + AG Y C Q SAT ++ A R + +
Sbjct: 3499 EGTRCELQICGLAMADAGEYLCVCGQERTSATLTIRA-------LPARFIEDVKNQEARE 3551
Query: 998 GRLGLLLCRVDSDPPAQLR-----LLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRL 1052
G +L C ++S P + R L GDR +L+ G L
Sbjct: 3552 GATAVLQCELNSAAPVEWRKGSETLRDGDRY---SLRQDG---------------TKCEL 3593
Query: 1053 EIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG---ATVREGQLVNLTCLV 1109
+I G + D G Y C GQ SA +A+ ++ G EG L C +
Sbjct: 3594 QIRGLAMADTGEYSC----VCGQERTSAMLTVRALPIKFTEGLRNEEATEGATAVLRCEL 3649
Query: 1110 WTTHPAQLTYTWYQDGQQRL---DAHS---------IPLPNVTVRDATSYRCGVGPPGRA 1157
P + W++ G + L D HS + + + DA Y C G +
Sbjct: 3650 SKMAPVE----WWK-GHETLRDGDRHSLRQDGARCELQIRGLVAEDAGEYLCMCGKERTS 3704
Query: 1158 PRLS-RPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASST 1216
L+ R + + RN E+ G A + C + P + H L
Sbjct: 3705 AMLTVRAMPSKFIEGLRN------EEATEGDTATLWCELSKAAPVEWRKGH--ETLRDGD 3756
Query: 1217 AASV---PNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEA---A 1270
S+ + L++RG D G YSC GQ TS L + + +
Sbjct: 3757 RHSLRQDGSRCELQIRGLAVVDAGEYSCVC----GQERTSATLTVRALPARFIEDVKNQE 3812
Query: 1271 VPEGAPITVTC----ADPAAHAPTLYTWYHNGRW--LQEGPAASLSFLVATRAHAGAYSC 1324
EGA + C A P T R+ Q+G L + A G YSC
Sbjct: 3813 AREGATAVLQCELSKAAPVEWRKGSETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSC 3872
Query: 1325 QAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHD 1382
R +A + APQ + +A S A +QC + SEP A
Sbjct: 3873 VC------GQERTSATLTVRAPQPVFREPLQSLQAEEGSTATLQCEL-SEPTA------- 3918
Query: 1383 GKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQ 1441
V+ + G+ A+G ++ L +QD+ D Y CT GS +T L
Sbjct: 3919 -TVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTC----GSQATSATLT 3973
Query: 1442 VEGARVVAEPGL---DVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP------ 1492
V A V L +V EG +L C L V W L P
Sbjct: 3974 VTAAPVRFLRELQHQEVDEGGTAHLCCELSRAGASVE-------WRKGSLQLFPCAKYQM 4026
Query: 1493 -----VPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGG 1547
L V + AG Y C TG S + + PK T + +E E G
Sbjct: 4027 VQDGAAAELLVRGVEQEDAGDYTC----DTGHTQSMASLSVRVPRPKFKTRLQSLEQETG 4082
Query: 1548 LRGILDCRV-DSEPLA-------SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVD 1599
L C++ D+E A + LH G + S QGA E IH
Sbjct: 4083 DIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRS--QGATRELLIH----------- 4129
Query: 1600 IEALRPSDQGEYICSASNVLGSAS 1623
L D GEY C +AS
Sbjct: 4130 --QLEAKDTGEYACVTGGQKTAAS 4151
Score = 108 bits (269), Expect = 6e-23
Identities = 242/1165 (20%), Positives = 397/1165 (34%), Gaps = 237/1165 (20%)
Query: 255 GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYT 304
G L+C+V A + + W KDG +L + + V L LPQA +DAG Y+
Sbjct: 1089 GASAMLSCEVAQ---AQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYS 1145
Query: 305 CQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTV---------TLVCNTPNEAPSD 355
C+A +S H+ + E P G + Q+V T + A
Sbjct: 1146 CEAG-------GQRVSFHLHITE----PKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQ 1194
Query: 356 LRYSWYKNHVLLEDAHSHTLRLHLATR---------ADTGFYFCEVQNVHGSER---SGP 403
+WYK+ L + + + TR AD G Y CE S + + P
Sbjct: 1195 TEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEP 1254
Query: 404 VSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP 463
+V ++ + T+AG L C V G + +S+
Sbjct: 1255 KAVFAKE----QLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSS-------- 1302
Query: 464 RFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN--------AARLLI 515
+ + +L ++ + D+GEY C A L FH + A L
Sbjct: 1303 KVRIEAAGCMRQLVVQQAGQADAGEYTCEA------GGQRLSFHLDVSEPKAVFAKEQLA 1356
Query: 516 SPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHE---------GPGSSLLLPAAS 566
+ G TLSC + T +WY +G L G L++ A
Sbjct: 1357 HRKVQAEAGAIATLSCEVAQAQT---EVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQAC 1413
Query: 567 STDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRV 626
D G Y C A G S A V++ QP A AG L C V
Sbjct: 1414 QADTGEYSCEA-GGQRLSFSLDVAEPKVVFAKEQPVHR------EVQAQAGASTTLSCEV 1466
Query: 627 DSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGL 686
A+ +++ S S GC+ R+ V +A + G
Sbjct: 1467 ---AQAQTEVMWYKDGKKLSFSSKVRMEAV-GCTRRLVVQQAGQAV-----------AGE 1511
Query: 687 YLCEASNA-----LGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPAN 741
Y CEA + L A A F A + + GT A L+C E A +
Sbjct: 1512 YSCEAGSQRLSFHLHVAEPKAVF---AKEQPASREVQAEAGTSATLSC----EVAQAQTE 1564
Query: 742 FSWFRNGV---------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQ-------LS 785
+W+++G + A G + + + DA Y+C+ AG Q ++
Sbjct: 1565 VTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCK----AGDQRLSFHLHVA 1620
Query: 786 TPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVP 845
P ++ P ++ A G A C V + G+ L ++S
Sbjct: 1621 EPKVVFAKEQPAHREVQA----EAGASATLSCEVAQAQTEVTWYKDGKKLSSSS------ 1670
Query: 846 SHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSP- 904
+ + +A + +L V++ G D+G Y CEA G S V Q+S P
Sbjct: 1671 ---KVRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQRLSFRLHVAELEPQISERPC 1723
Query: 905 -----ELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQES---------TSATLRFAAI 950
++E + ++L+ + T P + W +DG ++ S + TL
Sbjct: 1724 RREPLVVKEHEDIILTATLAT--PSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGA 1781
Query: 951 TLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSD 1010
+ + Y C+ A G V L++ G LG +
Sbjct: 1782 QVLDSAIYSCRVGAEGQ---------DFPVQVEEVAAKFCRLLEPVCGELGGTVTLACEL 1832
Query: 1011 PPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLR-LEIHGAMLEDEGVYICEA 1069
PA A + G + + VA +R L + G ED G Y+CE+
Sbjct: 1833 SPA----------CAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCES 1882
Query: 1070 SNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDG---- 1125
+ A + + EG C+V P+ + W++DG
Sbjct: 1883 RDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVV---SPSDVAVVWFRDGALLQ 1939
Query: 1126 -------QQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLT 1178
Q +HS+ + ++ + DA A S L V AP +
Sbjct: 1940 PSEKFAISQSGASHSLTISDLVLEDAGQITV------EAEGASSSAALRVREAPVLFKKK 1993
Query: 1179 YLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPR---- 1234
++ + ++ L +RP +L R ++TA + + + G + R
Sbjct: 1994 LEPQTVEERSSVTLEVELTRPWPEL------RWTRNATALAPGKNVEIHAEGARHRLVLH 2047
Query: 1235 -----DEGFYSCSARSPLGQANTSLELR----LEGVRVILAPEAAVPEGAPITVTCADPA 1285
D GF+ C QA ++E+R + G++ + A E T T
Sbjct: 2048 NVGFADRGFFGCETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQG-------TATMEVQL 2100
Query: 1286 AHAPTLYTWYHNGRWLQEGPAASLS 1310
+HA +W +G Q+GP L+
Sbjct: 2101 SHADVDGSWTRDGLRFQQGPTCHLA 2125
Score = 107 bits (268), Expect = 8e-23
Identities = 282/1306 (21%), Positives = 449/1306 (34%), Gaps = 223/1306 (17%)
Query: 441 ATLVLSHGGHILASTSGDSDHSP-----RFSGTSGPNSLRLEIRDLEETDSGEYKCSATN 495
ATL G+ S + D P RF + RL I DL DSG+Y C A N
Sbjct: 27 ATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARN 86
Query: 496 SLGNATSTLDFHANAAR---------LLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWY 546
++G A + + +A LL + V EG T CR G SP P SW
Sbjct: 87 AIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRP--AVSWS 144
Query: 547 LNGALLHE-----------GPGSSLLLPAASSTDAGSYHCRAR--------------DGH 581
+G L E G S+L + AA D G+Y RA D
Sbjct: 145 KDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSD 204
Query: 582 SASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDR 641
+A S P T + + A A G C V ARL
Sbjct: 205 AADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGE 264
Query: 642 VVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTS 701
++ G G + N + ++I + GLY C ASN +G +S
Sbjct: 265 PKPETVWKKDGQLVTEGRRHVVYEDAQENFV-LKILFCKQSDRGLYTCTASNLVGQTYSS 323
Query: 702 ATFNGQATVLAI---APSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV-LWA----- 752
+ + ++E A C V + + + +WF+ LWA
Sbjct: 324 VLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPSTEA----AWFKEETRLWASAKYG 379
Query: 753 ---QGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQ 809
+G +T+ V+ D A+Y C T G++ + + P+ +A +
Sbjct: 380 IEEEGTERRLTVRNVSADDDAVYICE--TPEGSRTVAELAVQGNLLRKLPRKTA---VRV 434
Query: 810 GHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869
G A+F C + P+ + + +V + GR AE L + + L
Sbjct: 435 GDTAMF-CVELAVPVGPVHWLRNQE--------EVVAGGRVAISAEGTRHTLTISQCCLE 485
Query: 870 DSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGV------- 922
D G + + G TS F V P LQ V+ ++ + V
Sbjct: 486 DVG----QVAFMAGDCQTSTQF-----CVSAPRKPPLQPPVDPVVKARMESSVILSWSPP 536
Query: 923 PEGT----------------SYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPG 966
P G +Y W R + AT + + G + + A
Sbjct: 537 PHGERPVTIDGYLVEKKKLGTYTWIRCH---EAEWVATPELTVADVAEEGNFQFRVSALN 593
Query: 967 SATTS--LAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVD-SDPPAQLRLLHGDRL 1023
S S L P ++H+ AP+ T L G + VD + A L G L
Sbjct: 594 SFGQSPYLEFPGTVHL--APKLAVRTPLKAVQAVEGGEVTFSVDLTVASAGEWFLDGQAL 651
Query: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFD 1083
AS++ E R + + +HGA L+ ++ + + A
Sbjct: 652 KASSVY-----EIHCDRTRHTLTIREVPASLHGAQLK----FVANGIESSIRMEVRA--- 699
Query: 1084 AQAVNVQVWPGATVRE--GQLVNLTCLVWTTHPAQLTYTWYQDG-----------QQRLD 1130
A + P A RE +L L+ TW +DG Q
Sbjct: 700 APGLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAG 759
Query: 1131 AHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVL--YAPRNLRLTYLLESHGGQL 1188
+ + +V DA Y C R R++ +++ L + +++ + + GG
Sbjct: 760 RRVLLVRDVARDDAGLYEC----VSRGGRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPA 815
Query: 1189 ALVLCTVDSRPPAQ-----LALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSA 1243
T ++ + L H+G V RL +DEG YSC
Sbjct: 816 QFECETSEAHVHVHWYKDGMELGHSGERFLQE---DVGTRHRLVAATVTRQDEGTYSCR- 871
Query: 1244 RSPLGQANTSLELRLEGVRVILAPE------AAVPEGAPITVTCADPAAHAPTLYTWYHN 1297
+G+ + LR+ +V+ A E GA T++C A A T TWY +
Sbjct: 872 ---VGEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSC--EVAQAQTEVTWYKD 926
Query: 1298 GRWLQEGPAASLSFLVATR---------AHAGAYSCQAQDAQGTRSSRPAALQVLYAPQD 1348
G+ L + TR A AG YSC+A + + +V++A +D
Sbjct: 927 GKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFA-KD 985
Query: 1349 AVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNA 1408
V S + A + A + C V ++ E+ DGK L++S VH A G R
Sbjct: 986 QVAHSEVQAEAGASATLSCEV-AQAQTEVMWYKDGKKLSSSLKVHVEAKG-----CRRRL 1039
Query: 1409 LRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV------AEPGLDVPEGAALN 1462
+ Q AGD Y C A+ S RL + +++ + GA+
Sbjct: 1040 VVQQAGKTDAGD--YSCEARGQRVSF----RLHITEPKMMFAKEQSVHNEVQAEAGASAM 1093
Query: 1463 LSCRLLGGPGPVGNSTFAWFWNDRRLHAEP---------VPTLAFTHVARAQAGMYHCLA 1513
LSC + V W+ + ++L + L +A AG Y C A
Sbjct: 1094 LSCEVAQAQTEV-----TWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEA 1148
Query: 1514 ELPTGAAASAPVMLRVLYP----PKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLG 1569
L + P K ++ V+ E G +L C V ++P +T +
Sbjct: 1149 -----GGQRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEV-AQPQTEVTWYKD 1202
Query: 1570 SRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSA 1615
+ ++SS + + R+ ++ + +D GEY C A
Sbjct: 1203 GKKLSSSS--------KVRMEVKGCTRRLVVQQVGKADAGEYSCEA 1240
Score = 106 bits (264), Expect = 2e-22
Identities = 312/1484 (21%), Positives = 520/1484 (35%), Gaps = 255/1484 (17%)
Query: 256 ELVTLTCQVNSSYPAVSSIKWLKDGVRL--QTKTGV--------LHLPQAAWSDAGVYTC 305
E T C+V P+ + W K+ RL K G+ L + + D VY C
Sbjct: 348 ESATFLCEVPQ--PSTEAA-WFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYIC 404
Query: 306 QAENGVGSLVSPPISLHI-----------------FMAEVQVSPAGPI--LENQTVTLVC 346
+ G ++ + ++ F E+ V P GP+ L NQ +
Sbjct: 405 ETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAV-PVGPVHWLRNQEEVVAG 463
Query: 347 NTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSV 406
+ R++ + LED +A T FC + R P+
Sbjct: 464 GRVAISAEGTRHTLTISQCCLEDVGQVAF---MAGDCQTSTQFCV-----SAPRKPPLQ- 514
Query: 407 VVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466
PP+ PV+ A +E+ L S P ++ G+++ + R
Sbjct: 515 ----PPVDPVVKARMESSVIL------SWSPPPHGERPVTIDGYLVEKKKLGTYTWIRCH 564
Query: 467 GTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN---AARLLISP---AAE 520
+ L + D+ E + +++ SA NS G + L+F A +L + A +
Sbjct: 565 EAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPY-LEFPGTVHLAPKLAVRTPLKAVQ 623
Query: 521 VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDG 580
VEG VT S + T + W+L+G L ++ HC R
Sbjct: 624 AVEGGEVTFS----VDLTVASAGEWFLDGQAL-------------KASSVYEIHCD-RTR 665
Query: 581 HSASGPSSPAVL---TVLYPPRQPTFTTRLDLDAAG--------AGAGRRGLLLCRVDSD 629
H+ + PA L + + + R+++ AA A A R +L R+ +
Sbjct: 666 HTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAARE--VLARLHEE 723
Query: 630 PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLC 689
+L D+ A + G + G P+ +V + + + + ++ GLY C
Sbjct: 724 AQLLAEL--SDQAAAVTWLKDGRTLSPG---PKYEVQASAGRRVLLVRDVARDDAGLYEC 778
Query: 690 EASNALGNASTSATFNGQATVLAIAPSHTLQE---GTEANLTCNVSREAAGSPANFSWFR 746
+ G + + G A L + + + G A C S + + W++
Sbjct: 779 VSRG--GRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPAQFECETSE----AHVHVHWYK 832
Query: 747 NGVLWAQ----------GPLETVTLLPVARTDAALYACRILTEA---GAQLSTPVLLSVL 793
+G+ G + V R D Y+CR+ ++ ++S P ++
Sbjct: 833 DGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKVVFAK 892
Query: 794 YPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAK 853
R KL A G A C V + G+ L ++S + +
Sbjct: 893 EQLARRKLQA----EAGASATLSCEVAQAQTEVTWYKDGKKLSSSS---------KVCME 939
Query: 854 AEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV-----QVSPSP-ELQ 907
A + +L V++ G D+G Y CEA G S V+ V QV+ S + +
Sbjct: 940 ATGCTRRLVVQQAGQADAGEYSCEA----GGQRLSFHLDVKEPKVVFAKDQVAHSEVQAE 995
Query: 908 EGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSA---------TLRFAAITLTQAGAY 958
G + LSC+V T WY+DG+ L S L T AG Y
Sbjct: 996 AGASATLSCEV---AQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDY 1052
Query: 959 HCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLL 1018
C+A+ S I+ + ++ + G +L C V
Sbjct: 1053 SCEAR---GQRVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQTEVTWYK 1109
Query: 1019 HGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA-----SNTL 1073
G +L SS ++ + V T RL + A D G Y CEA S L
Sbjct: 1110 DGKKL------------SSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSFHL 1157
Query: 1074 GQASASADF-DAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH 1132
F Q+V+ +V A G L+C V Q TWY+DG++ +
Sbjct: 1158 HITEPKGVFAKEQSVHNEVQAEA----GTTAMLSCEV---AQPQTEVTWYKDGKKLSSSS 1210
Query: 1133 SIPL-----------PNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLL 1181
+ + V DA Y C G G+ IT + + +
Sbjct: 1211 KVRMEVKGCTRRLVVQQVGKADAGEYSCEAG--GQRVSFQLHITEPKAVFAKEQLVHNEV 1268
Query: 1182 ESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT---LRLELRGPQPRDEGF 1238
+ G A + C V ++ ++ G+ L+SS+ + +L ++ D G
Sbjct: 1269 RTEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGE 1327
Query: 1239 YSCSARSPLGQANTSLELRLEGVRVILAPE------AAVPEGAPITVTCADPAAHAPTLY 1292
Y+C A G S L + + + A E GA T++C A A T
Sbjct: 1328 YTCEA----GGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSC--EVAQAQTEV 1381
Query: 1293 TWYHNGRWLQEGPAASLSFLVATR---------AHAGAYSCQAQDAQGTRSSRPAALQVL 1343
TWY +G+ L + + TR A G YSC+A + + S A +V+
Sbjct: 1382 TWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVV 1441
Query: 1344 YAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403
+A + V + ++A + + C V ++ E+ DGK L+ SS V A G
Sbjct: 1442 FAKEQPVHREVQ-AQAGASTTLSCEV-AQAQTEVMWYKDGKKLSFSSKVRMEAVG----- 1494
Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNL 1463
R + Q AG+ + +Q L + V A + G + L
Sbjct: 1495 CTRRLVVQQAGQAVAGEYSCEAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATL 1554
Query: 1464 SCRLLGGPGPVGNSTFAWFWNDRRLHAEP---------VPTLAFTHVARAQAGMYHCLA- 1513
SC + V W+ + ++L + L +A AG Y C A
Sbjct: 1555 SCEVAQAQTEV-----TWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAG 1609
Query: 1514 --ELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSR 1571
L + P +V++ + P V+ E G L C V G +
Sbjct: 1610 DQRLSFHLHVAEP---KVVFAKEQPAHRE-VQAEAGASATLSCEVAQAQTEVTWYKDGKK 1665
Query: 1572 LVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSA 1615
L +SS+ + V A R+ ++ +D GEY C A
Sbjct: 1666 LSSSSK---------VRVEAVGCTRRLVVQQAGQADAGEYSCEA 1700
Score = 104 bits (260), Expect = 6e-22
Identities = 291/1322 (22%), Positives = 444/1322 (33%), Gaps = 219/1322 (16%)
Query: 94 EHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEG 153
E + L+++ +D+G Y E S+ V+ TEE L
Sbjct: 2877 EGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEE------------LTN 2924
Query: 154 TEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFN--------SQKFEPTGVGHLETLHMA 205
+V+ + + C E PA +VT+ S K +P+ G L ++
Sbjct: 2925 LQVEEKGTAVFTCKTEH---------PAATVTWRKGLLELRASGKHQPSQEGLTLRLTIS 2975
Query: 206 MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVN 265
+ C + A RAQ + + V I+ ++ G T C+++
Sbjct: 2976 ALEKADSDTYTCDIGQAQSRAQLLVQ------GRRVHIIEDLEDVDVQEGSSATFRCRIS 3029
Query: 266 SSYPAVSSIKWLKDGVRLQTKT-----------GVLHLPQAAWSDAG-VYTCQAENGVGS 313
+ + W D L VL L Q A D+G +Y + +
Sbjct: 3030 PAN--YEPVHWFLDKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEAGDQRASA 3087
Query: 314 LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLE----- 368
+ +F E+ + I E + +TLVC T + D+ W K+ L
Sbjct: 3088 ALRVTEKPSVFSRELTDAT---ITEGEDLTLVCET---STCDIPVCWTKDGKTLRGSARC 3141
Query: 369 ----DAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQ 424
+ H L + AT D+G Y CE G S + V P LE
Sbjct: 3142 QLSHEGHRAQLLITGATLQDSGRYKCEA----GGACSSSIVRVHARPVRFQEALKDLEVL 3197
Query: 425 AGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEET 484
G L C V+S A + +G ++L GD +S R G L L +R+L
Sbjct: 3198 EGGAATLRC-VLSSVAAPVKWCYGNNVLRP--GDK-YSLRQEGAM----LELVVRNLRPQ 3249
Query: 485 DSGEYKCSATNSLGNATSTLDFHANAARLLIS-PAAEVVEGQAVTLSCR-SGLSPTPDAR 542
DSG Y CS + +AT T+ A A+ + E EG TL C S +P +
Sbjct: 3250 DSGRYSCSFGDQTTSATLTVT--ALPAQFIGKLRNKEATEGATATLRCELSKAAPVEWRK 3307
Query: 543 FSWYLNG----ALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
S L L +G L + + DA Y C + ++ A LT+ P
Sbjct: 3308 GSETLRDGDRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTS------ASLTI--RP 3359
Query: 599 RQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGG 658
F RL + GA L C + P R SL G
Sbjct: 3360 MPAHFIGRLRHQESIEGA--TATLRCELSKAAPVEW------RKGRESLRDG-------- 3403
Query: 659 CSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAP--- 715
R + + + ++I + + G Y C G TSAT +A
Sbjct: 3404 --DRHSLRQDGAVCELQICGLAVADAGEYSC----VCGEERTSATLTVKALPAKFTEGLR 3457
Query: 716 SHTLQEGTEANLTCNVSR----EAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAAL 771
+ EG A L C +S+ E P N +L +G + + +A DA
Sbjct: 3458 NEEAVEGATAMLWCELSKVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGE 3517
Query: 772 YACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFH 831
Y C E + T L + D A +G A+ C ++S A +
Sbjct: 3518 YLCVCGQERTSATLTIRALPARFIEDVKNQEA----REGATAVLQCELNS--AAPVEWRK 3571
Query: 832 GEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFF 891
G L R+ + + +L++R L + D+G Y C V G TS
Sbjct: 3572 GSETLRDG--------DRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAML 3619
Query: 892 QVRGAWVQVSP---SPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL---------QE 939
VR ++ + + E EG VL C++ P W++ + L Q+
Sbjct: 3620 TVRALPIKFTEGLRNEEATEGATAVLRCELSKMAP----VEWWKGHETLRDGDRHSLRQD 3675
Query: 940 STSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGR 999
L+ + AG Y C G TS + S + + + G
Sbjct: 3676 GARCELQIRGLVAEDAGEYLCMC---GKERTSAMLTVRAMPS---KFIEGLRNEEATEGD 3729
Query: 1000 LGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAML 1059
L C + P + R H TL+ R + + L+I G +
Sbjct: 3730 TATLWCELSKAAPVEWRKGH------ETLR-------DGDRHSLRQDGSRCELQIRGLAV 3776
Query: 1060 EDEGVYIC-----EASNTLGQASASADFDAQAVNVQVWPGAT-VREGQLVNLTCLVWTTH 1113
D G Y C S TL + A F N + GAT V + +L + W
Sbjct: 3777 VDAGEYSCVCGQERTSATLTVRALPARFIEDVKNQEAREGATAVLQCELSKAAPVEWRKG 3836
Query: 1114 PAQL----TYTWYQDGQQ-RLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV 1168
L Y+ QDG + L H + +V D Y C G + L+ V
Sbjct: 3837 SETLRGGDRYSLRQDGTRCELQIHGL-----SVADTGEYSCVCGQERTSATLTVRAPQPV 3891
Query: 1169 LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPN----TL 1224
P L++ G A + C + S P A + S G L + P T
Sbjct: 3892 FREP-----LQSLQAEEGSTATLQCEL-SEPTATVVWSKGG-LQLQANGRREPRLQGCTA 3944
Query: 1225 RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPE---AAVPEGAPITVTC 1281
L L+ Q D G Y+C+ G TS L + V E V EG + C
Sbjct: 3945 ELVLQDLQREDTGEYTCTC----GSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLCC 4000
Query: 1282 ADPAAHAPTLYTWYHNG---------RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGT 1332
+ A W + +Q+G AA L + AG Y+C Q
Sbjct: 4001 --ELSRAGASVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSM 4058
Query: 1333 RS 1334
S
Sbjct: 4059 AS 4060
Score = 103 bits (257), Expect = 1e-21
Identities = 274/1256 (21%), Positives = 423/1256 (33%), Gaps = 235/1256 (18%)
Query: 274 IKWLKDGVRL--------QTKTGVLHLPQAAW---SDAGVYTCQA-ENGVGSLVSPPISL 321
+ W KDG+ L Q G H AA D G Y+C+ E+ V +
Sbjct: 828 VHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPK 887
Query: 322 HIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH---------S 372
+F E + TL C A + +WYK+ L + +
Sbjct: 888 VVFAKEQLARRKLQAEAGASATLSCEV---AQAQTEVTWYKDGKKLSSSSKVCMEATGCT 944
Query: 373 HTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLT----PVLTAFLETQAGLV 428
L + A +AD G Y CE G +R + V P + V + ++ +AG
Sbjct: 945 RRLVVQQAGQADAGEYSCEA----GGQRLS-FHLDVKEPKVVFAKDQVAHSEVQAEAGAS 999
Query: 429 GILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGE 488
L C V + G + +S + + RL ++ +TD+G+
Sbjct: 1000 ATLSCEVAQAQTEVMWYKDGKKLSSSLKVHVE--------AKGCRRRLVVQQAGKTDAGD 1051
Query: 489 YKCSATNSLGNATSTLDFHANAARLLISPAAEVVE------GQAVTLSCRSGLSPTPDAR 542
Y C A + H +++ + V G + LSC + T
Sbjct: 1052 YSCEARGQ----RVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQT---E 1104
Query: 543 FSWYLNGALLH---------EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLT 593
+WY +G L +G L+LP A DAG Y C A G +
Sbjct: 1105 VTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEA-------GGQRVSFHL 1157
Query: 594 VLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGC 653
+ P+ + + A AG +L C V P +KD +S S
Sbjct: 1158 HITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQ--PQTEVTWYKDGKKLSS--SSKVR 1213
Query: 654 STCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAI 713
GC+ R+ V + + G Y CEA S V A
Sbjct: 1214 MEVKGCTRRLVVQQVGKA-----------DAGEYSCEAGGQ--RVSFQLHITEPKAVFAK 1260
Query: 714 APSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLETVTLLPV 764
+ TEA + +S E A + +W+++G + A G + + +
Sbjct: 1261 EQLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQA 1320
Query: 765 ARTDAALYACRILTEAGAQ-------LSTPVLLSVLYPPDRPKLSALLDMGQGHMALFIC 817
+ DA Y C EAG Q +S P + K+ A G +A C
Sbjct: 1321 GQADAGEYTC----EAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQA----EAGAIATLSC 1372
Query: 818 TVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCE 877
V + G+ L ++S + + +A + +L V++ D+G Y CE
Sbjct: 1373 EVAQAQTEVTWYKDGKKLSSSS---------KVRMEAVGCTRRLVVQQACQADTGEYSCE 1423
Query: 878 ATNVLGSSNTSLFFQVRGAWV------QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWY 931
A G S V V V + Q G + LSC+V T WY
Sbjct: 1424 A----GGQRLSFSLDVAEPKVVFAKEQPVHREVQAQAGASTTLSCEV---AQAQTEVMWY 1476
Query: 932 RDGQPLQESTSATLRFAAITLTQ-----------AGAYHCQAQAPGSATTSLAAPISLHV 980
+DG+ L S S+ +R A+ T+ AG Y C+A GS S ++
Sbjct: 1477 KDGKKL--SFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCEA---GSQRLSFHLHVAEPK 1531
Query: 981 SYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPR 1040
+ + + + G L C V G +L SS +
Sbjct: 1532 AVFAKEQPASREVQAEAGTSATLSCEVAQAQTEVTWYKDGKKL------------SSSSK 1579
Query: 1041 LHVAVAPNTLRLEIHGAMLEDEGVYICEASNT-----LGQASASADFDAQAV---NVQVW 1092
+ + T RL + A D G Y C+A + L A F + VQ
Sbjct: 1580 VRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAE 1639
Query: 1093 PGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVR---------- 1142
GA+ L+C V AQ TWY+DG++ + + + V
Sbjct: 1640 AGASA------TLSCEV---AQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQ 1690
Query: 1143 -DATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALV--LCTVDSRP 1199
DA Y C G + RL L+ + R R L+ + L L T +
Sbjct: 1691 ADAGEYSCEAGGQRLSFRL-HVAELEPQISERPCRREPLVVKEHEDIILTATLATPSAAT 1749
Query: 1200 PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE 1259
L R AS +T L + G Q D YSC +G +++E
Sbjct: 1750 VTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCR----VGAEGQDFPVQVE 1805
Query: 1260 GVRV----ILAPEAAVPEGAPITVTCADPAAHAPTLY----TWYHNGRWLQ---EGPAAS 1308
V +L P G +T+ C A A ++ T G+ Q EGP S
Sbjct: 1806 EVAAKFCRLLEPVCG-ELGGTVTLACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRS 1864
Query: 1309 LSFLVATRAHAGAYSCQAQD----AQGTRS------------------SRPAALQVLYAP 1346
L+ L AG Y C+++D AQ T S A Q + +P
Sbjct: 1865 LTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVVSP 1924
Query: 1347 QDAVLSSFRDSR----ARSMAVIQCTVD-SEPPAELALSHDGKVLATSSGVHSLAS 1397
D + FRD + A+ Q S ++L L G++ + G S A+
Sbjct: 1925 SDVAVVWFRDGALLQPSEKFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAA 1980
Score = 102 bits (255), Expect = 2e-21
Identities = 283/1294 (21%), Positives = 450/1294 (34%), Gaps = 235/1294 (18%)
Query: 59 WYYDYSGQRQVVSHSADPKLVEARFRG--------RTEFMGNPEHRVCNLLLKDLQPEDS 110
W G+R V + D LVE + G E++ PE L + D+ E
Sbjct: 533 WSPPPHGERPV---TIDGYLVEKKKLGTYTWIRCHEAEWVATPE-----LTVADVAEEG- 583
Query: 111 GSYNFRFEISEVNRWS-----DVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYV 165
NF+F +S +N + + GT V + + V T V+ +EG EV F+
Sbjct: 584 ---NFQFRVSALNSFGQSPYLEFPGT-VHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVA 639
Query: 166 CLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLE---TLHMAMSWQDHGRILRCQLSVA 222
E W + Q + + V + T H + + QL
Sbjct: 640 SAGE-----W---------FLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFV 685
Query: 223 NHRAQSEIHLQVKYAPKGVKILLSPSG--RNILPG--ELVTLTCQVNSSYPAVSSIKWLK 278
+ +S I ++V+ AP G+ P+ R +L E L +++ AV+ WLK
Sbjct: 686 ANGIESSIRMEVRAAP-GLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVT---WLK 741
Query: 279 DGVRL--------QTKTG--VLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEV 328
DG L Q G VL + A DAG+Y C + G + L F+ +
Sbjct: 742 DGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKD 801
Query: 329 QVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHV---------LLEDAHS-HTLRLH 378
+ C T + + + WYK+ + L ED + H L
Sbjct: 802 MAGSCVDAVAGGPAQFECET---SEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAA 858
Query: 379 LATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLT----PVLTAFLETQAGLVGILHCS 434
TR D G Y C V E S + V+ P + + L+ +AG L C
Sbjct: 859 TVTRQDEGTYSCRV-----GEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSCE 913
Query: 435 VVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSAT 494
V G + +S+ + + + RL ++ + D+GEY C A
Sbjct: 914 VAQAQTEVTWYKDGKKLSSSS--------KVCMEATGCTRRLVVQQAGQADAGEYSCEAG 965
Query: 495 NSLGNATSTLDFHANAARLLISPAAEVVE--------GQAVTLSCRSGLSPTPDARFSWY 546
L FH + + A + V G + TLSC + T WY
Sbjct: 966 GQ------RLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSCEVAQAQT---EVMWY 1016
Query: 547 LNGALLH---------EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYP 597
+G L +G L++ A TDAG Y C AR G S +++
Sbjct: 1017 KDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEAR-GQRVSFRLHITEPKMMFA 1075
Query: 598 PRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLL-HKDRVVATSLPSGGGCSTC 656
Q + A AG +L C V A+ ++ +KD +S G
Sbjct: 1076 KEQSVH------NEVQAEAGASAMLSCEV---AQAQTEVTWYKDGKKLSSSSKVG--MEV 1124
Query: 657 GGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPS 716
GC+ R+ + +A + G Y CEA S V A S
Sbjct: 1125 KGCTRRLVLPQAGK-----------ADAGEYSCEAGGQ--RVSFHLHITEPKGVFAKEQS 1171
Query: 717 HTLQEGTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLETVTLLPVART 767
+ EA T +S E A +W+++G + +G + + V +
Sbjct: 1172 VHNEVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKA 1231
Query: 768 DAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLD----MGQGHMALFICTVDSRP 823
DA Y+C EAG Q L + P L+ G A C V
Sbjct: 1232 DAGEYSC----EAGGQ-RVSFQLHITEPKAVFAKEQLVHNEVRTEAGASATLSCEVAQAQ 1286
Query: 824 LALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLG 883
+ G+ L ++S + + +A +L V++ G D+G Y CEA G
Sbjct: 1287 TEVTWYKDGKKLSSSS---------KVRIEAAGCMRQLVVQQAGQADAGEYTCEA----G 1333
Query: 884 SSNTSLFFQVRGAWVQVSPSP------ELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL 937
S V + + + G LSC+V E T WY+DG+ L
Sbjct: 1334 GQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQTEVT---WYKDGKKL 1390
Query: 938 QESTSATLRFAAITLTQ-----------AGAYHCQAQAPG-SATTSLAAPISLHVSYAPR 985
S+S+ +R A+ T+ G Y C+A S + +A P + P
Sbjct: 1391 --SSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVFAKEQPV 1448
Query: 986 HVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAV 1045
H + G L C V + G +L S ++ +
Sbjct: 1449 H----REVQAQAGASTTLSCEVAQAQTEVMWYKDGKKL------------SFSSKVRMEA 1492
Query: 1046 APNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNL 1105
T RL + A G Y CEA + + +AV + P + + +
Sbjct: 1493 VGCTRRLVVQQAGQAVAGEYSCEAGSQRLSFHLHV-AEPKAVFAKEQPASREVQAEAGTS 1551
Query: 1106 TCLVWTTHPAQLTYTWYQDGQQ-------RLDA----HSIPLPNVTVRDATSYRCGVGPP 1154
L AQ TWY+DG++ R++A + + DA Y C G
Sbjct: 1552 ATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQ 1611
Query: 1155 GRAPRL--SRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLL 1212
+ L + P + P + +++ G A + C V ++ ++ G+ L
Sbjct: 1612 RLSFHLHVAEPKVVFAKEQPAHRE----VQAEAGASATLSCEV-AQAQTEVTWYKDGKKL 1666
Query: 1213 ASST---AASVPNTLRLELRGPQPRDEGFYSCSA 1243
+SS+ +V T RL ++ D G YSC A
Sbjct: 1667 SSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA 1700
Score = 94.7 bits (234), Expect = 7e-19
Identities = 329/1543 (21%), Positives = 511/1543 (33%), Gaps = 276/1543 (17%)
Query: 229 EIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSS-YPAVSSIKWLKDGVRLQTKT 287
++ + A + LL P+ + G T C+V S PAVS W KDG RL
Sbjct: 98 QVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVS---WSKDGRRLGEPD 154
Query: 288 G------------VLHLPQAAWSDAGVYTCQAENGVGSLVS----------------PPI 319
G L + A D G Y +AEN +G+ + P
Sbjct: 155 GPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGT 214
Query: 320 SLHIFMAEVQV---------SPAGP---------ILENQTVTLVCNTPNEAPSDLRYSWY 361
S +A +Q +PA P + E + L C E + W
Sbjct: 215 STAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPET--VWK 272
Query: 362 KN---------HVLLEDAHSH-TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHP 411
K+ HV+ EDA + L++ ++D G Y C N+ G S + VV
Sbjct: 273 KDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVV--RE 330
Query: 412 PLTPVLTAF--LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTS 469
P P LE + C V + AS + GT
Sbjct: 331 PAVPFKKRLQDLEVREKESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEE----GTE 386
Query: 470 GPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTL 529
RL +R++ D Y C + L N R L P V +
Sbjct: 387 R----RLTVRNVSADDDAVYICETPEG-SRTVAELAVQGNLLRKL--PRKTAVRVGDTAM 439
Query: 530 SCRSGLSPTPDARFSWYLNG---------ALLHEGPGSSLLLPAASSTDAGSY-----HC 575
C P W N A+ EG +L + D G C
Sbjct: 440 FCVELAVPVGPVH--WLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDC 497
Query: 576 RARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635
+ S P P L PP P R++ + S PP +
Sbjct: 498 QTSTQFCVSAPRKPP----LQPPVDPVVKARMESSVILSW------------SPPPHGER 541
Query: 636 LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695
+ D + G T C V P L ++ EEG + S AL
Sbjct: 542 PVTIDGYLVEKKKLG--TYTWIRCHEAEWVA-TPELTVADV-----AEEGNFQFRVS-AL 592
Query: 696 GNASTSATFNGQATV-----LAI-APSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRN 747
+ S TV LA+ P +Q EG E + +++ +AG WF +
Sbjct: 593 NSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVASAGE-----WFLD 647
Query: 748 G-VLWAQGPLE-----TVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPP----D 797
G L A E T L + A+L+ ++ A + + + + V P +
Sbjct: 648 GQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANG-IESSIRMEVRAAPGLTAN 706
Query: 798 RPKLSALLD-MGQGHM-ALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAE 855
+P +A + + + H A + + + A+ L G L S GP +++ +A
Sbjct: 707 KPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTL---SPGP------KYEVQAS 757
Query: 856 ANSLKLEVRELGLGDSGSYRCEA--------TNVLGSSNTSLFFQVRGAWVQ-VSPSPEL 906
A L VR++ D+G Y C + +V G + L + G+ V V+ P
Sbjct: 758 AGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLAR-FLHKDMAGSCVDAVAGGPAQ 816
Query: 907 QEGQAVVLSCQVHTGVPEGTSYRWYRDGQP--------LQESTSATLRFAAITLTQ--AG 956
E + VH WY+DG LQE R A T+T+ G
Sbjct: 817 FECETSEAHVHVH----------WYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEG 866
Query: 957 AYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLR 1016
Y C+ G + +S + + G L C V
Sbjct: 867 TYSCRV---GEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVTW 923
Query: 1017 LLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQA 1076
G +L SS ++ + T RL + A D G Y CEA G
Sbjct: 924 YKDGKKL------------SSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEA----GGQ 967
Query: 1077 SASADFDAQAVNV-----QVWPGATVRE-GQLVNLTCLVWTTHPAQLTYTWYQDGQQ--- 1127
S D + V QV E G L+C V AQ WY+DG++
Sbjct: 968 RLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSCEV---AQAQTEVMWYKDGKKLSS 1024
Query: 1128 RLDAH--------SIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY 1179
L H + + DA Y C G+ IT + + +
Sbjct: 1025 SLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEA--RGQRVSFRLHITEPKMMFAKEQSVHN 1082
Query: 1180 LLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVP---NTLRLELRGPQPRDE 1236
+++ G A++ C V ++ ++ G+ L+SS+ + T RL L D
Sbjct: 1083 EVQAEAGASAMLSCEV-AQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADA 1141
Query: 1237 GFYSCSARSPLGQANTSLELRLEGVRVILAPEAA----VPEGAPITVTCADPAAHAPTLY 1292
G YSC A G S L + + + A E + V A T + A T
Sbjct: 1142 GEYSCEA----GGQRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEV 1197
Query: 1293 TWYHNGRWLQEGPAASLSFLVATR---------AHAGAYSCQAQDAQGTRSSRPAALQVL 1343
TWY +G+ L + TR A AG YSC+A + + + +
Sbjct: 1198 TWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEPKAV 1257
Query: 1344 YAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403
+A + V + R + A + A + C V ++ E+ DGK L++SS V A+G
Sbjct: 1258 FAKEQLVHNEVR-TEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRIEAAG----- 1310
Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNL 1463
R + Q AG+ T Q L + V +A + GA L
Sbjct: 1311 CMRQLVVQQAGQADAGEYTCEAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATL 1370
Query: 1464 SCRLLGGPGPVGNSTFAWFWNDRRLHAEP---------VPTLAFTHVARAQAGMYHCLAE 1514
SC + V W+ + ++L + L +A G Y C A
Sbjct: 1371 SCEVAQAQTEV-----TWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAG 1425
Query: 1515 LPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVA 1574
+ + +V++ + P V+ + G L C V + G +L
Sbjct: 1426 GQRLSFSLDVAEPKVVFAKEQPVHRE-VQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSF 1484
Query: 1575 SSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASN 1617
SS+ + + A R+ ++ + GEY C A +
Sbjct: 1485 SSK---------VRMEAVGCTRRLVVQQAGQAVAGEYSCEAGS 1518
Score = 94.7 bits (234), Expect = 7e-19
Identities = 362/1685 (21%), Positives = 573/1685 (34%), Gaps = 282/1685 (16%)
Query: 78 LVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTE 137
L+E R G+ + + E L + L+ DS +Y ++ V+G V + E
Sbjct: 2952 LLELRASGKHQ--PSQEGLTLRLTISALEKADSDTYTCDIGQAQSRAQLLVQGRRVHIIE 3009
Query: 138 EPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQW-QGQDPARSVTFNSQKFEPTGV 196
+ V++ EG+ F C + + W + P + N +P G
Sbjct: 3010 D------LEDVDVQEGSSATFRCR---ISPANYEPVHWFLDKTPLHANELNEIDAQPGGY 3060
Query: 197 GHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGE 256
H+ TL ++ +D G I + RA + + + K + ++ + I GE
Sbjct: 3061 -HVLTLRQ-LALKDSGTIY---FEAGDQRASAALRVTEKPSVFSREL----TDATITEGE 3111
Query: 257 LVTLTCQVNSSYPAVSSIKWLKDGVRLQTKT----------GVLHLPQAAWSDAGVYTCQ 306
+TL C+ ++ V W KDG L+ L + A D+G Y C+
Sbjct: 3112 DLTLVCETSTCDIPVC---WTKDGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKCE 3168
Query: 307 AENGVGSLV----SPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYK 362
A S + + P+ + +++V LE TL C + A W
Sbjct: 3169 AGGACSSSIVRVHARPVRFQEALKDLEV------LEGGAATLRCVLSSVAAP---VKWCY 3219
Query: 363 NHVLLEDAHSHTLR-----LHLATR----ADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413
+ +L ++LR L L R D+G Y C G + + V P
Sbjct: 3220 GNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSF----GDQTTSATLTVTALPAQ 3275
Query: 414 TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNS 473
E G L C + A + G L GD R+
Sbjct: 3276 FIGKLRNKEATEGATATLRCEL--SKAAPVEWRKGSETLRD--GD-----RYCLRQDGAM 3326
Query: 474 LRLEIRDLEETDSGEYKCSATNSLGNATSTL-DFHANAARLLISPAAEVVEGQAVTLSCR 532
L+IR L D+ EY C +A+ T+ A+ L E +EG TL C
Sbjct: 3327 CELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFIGRL--RHQESIEGATATLRCE 3384
Query: 533 SGLSPTPDARFSWYLNGALLHEGPGSSLLLPAA---------SSTDAGSYHCRARDGHSA 583
+ A W L +G SL A + DAG Y C + ++
Sbjct: 3385 LSKA----APVEWRKGRESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSCVCGEERTS 3440
Query: 584 SGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVV 643
A LTV P + FT L + A GA +L C + P R
Sbjct: 3441 ------ATLTVKALPAK--FTEGLRNEEAVEGA--TAMLWCELSKVAPVEW------RKG 3484
Query: 644 ATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSAT 703
+L G R + + ++I + + G YLC G TSAT
Sbjct: 3485 PENLRDG----------DRYILRQEGTRCELQICGLAMADAGEYLC----VCGQERTSAT 3530
Query: 704 FNGQ---ATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSW------FRNG---VLW 751
+ A + + +EG A L C ++ S A W R+G L
Sbjct: 3531 LTIRALPARFIEDVKNQEAREGATAVLQCELN-----SAAPVEWRKGSETLRDGDRYSLR 3585
Query: 752 AQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGH 811
G + + +A D Y+C E + + T L + + A +G
Sbjct: 3586 QDGTKCELQIRGLAMADTGEYSCVCGQERTSAMLTVRALPIKFTEGLRNEEAT----EGA 3641
Query: 812 MALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDS 871
A+ C + +A + + G L R + + +L++R L D+
Sbjct: 3642 TAVLRCELSK--MAPVEWWKGHETLRDG--------DRHSLRQDGARCELQIRGLVAEDA 3691
Query: 872 GSYRCEATNVLGSSNTSLFFQVR---GAWVQVSPSPELQEGQAVVLSCQVHTGVPE--GT 926
G Y C + G TS VR +++ + E EG L C++ P
Sbjct: 3692 GEYLC----MCGKERTSAMLTVRAMPSKFIEGLRNEEATEGDTATLWCELSKAAPVEWRK 3747
Query: 927 SYRWYRDGQP---LQESTSATLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSY 982
+ RDG Q+ + L+ + + AG Y C Q SAT ++ A
Sbjct: 3748 GHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTSATLTVRA-------L 3800
Query: 983 APRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLH 1042
R + + G +L C + P + R + TL+G R
Sbjct: 3801 PARFIEDVKNQEAREGATAVLQCELSKAAPVEW------RKGSETLRG-------GDRYS 3847
Query: 1043 VAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQA---VNVQVWPGATVRE 1099
+ L+IHG + D G Y C GQ SA +A V + E
Sbjct: 3848 LRQDGTRCELQIHGLSVADTGEYSC----VCGQERTSATLTVRAPQPVFREPLQSLQAEE 3903
Query: 1100 GQLVNLTC--------LVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGV 1151
G L C +VW+ QL ++ + + + L ++ D Y C
Sbjct: 3904 GSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTC 3963
Query: 1152 GPPGRAPRLSRPITLDVLYAP-RNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAG- 1209
G + TL V AP R LR E G A + C + SR A +
Sbjct: 3964 GSQATS------ATLTVTAAPVRFLRELQHQEVDEGGTAHLCCEL-SRAGASVEWRKGSL 4016
Query: 1210 RLLASSTAASVPNTLRLEL--RGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP 1267
+L + V + EL RG + D G Y+C Q+ SL +R+ +
Sbjct: 4017 QLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHT--QSMASLSVRVPRPKFKTRL 4074
Query: 1268 EAAVPEGAPITVTCADPA-AHAPTLYTWYHNGRWLQEGPAASLSFLVATR---------A 1317
++ E I C + A + + W G L GP + ATR
Sbjct: 4075 QSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEAK 4134
Query: 1318 HAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQ--CTVDSEPPA 1375
G Y+C T + AA + P+ ++ D+ + ++ C V
Sbjct: 4135 DTGEYACV------TGGQKTAASLRVTEPEVTIVRGLVDAEVTADEDVEFSCEVSRAGAT 4188
Query: 1376 ELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQ-VQDVPAGDDTYVCTAQNLLGSI 1434
+ G L S+ V +A G + + LRL+ V AG T LG+
Sbjct: 4189 GVQWCLQGLPL-QSNEVTEVAVRDGRI----HTLRLKGVTPEDAG------TVSFHLGNH 4237
Query: 1435 STIGRLQVEGARV-VAEPGLDV--PEGAALNLSCRLLGGPGPV------GNSTFAWFWND 1485
++ +L V V + EP DV EG + CRL G G A ND
Sbjct: 4238 ASSAQLTVRAPEVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMND 4297
Query: 1486 RRLHAEPVPTLAFTHVARAQAG--MYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVE 1543
+ + L V AG +H S+ L+V + VE
Sbjct: 4298 ITVEQGTLHLLTLHKVTLEDAGTVSFHV-------GTCSSEAQLKVTAKNTVVRGLENVE 4350
Query: 1544 PEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALR--VDIE 1601
G + +C++ +A+ T L V +S+ + V+ N LR + ++
Sbjct: 4351 ALEGGEALFECQLSQPEVAAHTWLLDDEPVHTSE--------NAEVVFFENGLRHLLLLK 4402
Query: 1602 ALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGL--LLLLLGL 1659
LRP D C + + G TS + VR W L +L L + G
Sbjct: 4403 NLRPQDS----CRVTFLAGDMVTSAFLTVRG-----------WRLEILEPLKNAAVRAGA 4447
Query: 1660 GACYT 1664
AC+T
Sbjct: 4448 QACFT 4452
Score = 85.9 bits (211), Expect = 3e-16
Identities = 282/1247 (22%), Positives = 418/1247 (33%), Gaps = 244/1247 (19%)
Query: 508 ANAARLLISPAAEVVE-GQAVTLSCRSGLSPTPDARFSWYLN------GA---LLHEGPG 557
+ A R L P A VV G+ TLSC+ +PTP SW + GA L +G
Sbjct: 7 SGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQV--SWEKDQQPVAAGARFRLAQDGDL 64
Query: 558 SSLLLPAASSTDAGSYHCRARD--GHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAG 615
L + + D+G Y CRAR+ G + + + P F R +
Sbjct: 65 YRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPT--SIRVR 122
Query: 616 AGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVE 675
G CRV P + R + P G PR++V + +
Sbjct: 123 EGSEATFRCRVGGSPRPAVSWSKDGRRLGE--PDG----------PRVRVEELGEASALR 170
Query: 676 IHNPLLEEEGLYLCEASNALGNASTSA----------TFNGQATVLAIAPSH-------- 717
I + G Y A N LG AS +A T + T A +H
Sbjct: 171 IRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAM 230
Query: 718 -----------------TLQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETV- 759
T+ EG A L+C V+ E W ++G L +G V
Sbjct: 231 RAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETV---WKKDGQLVTEGRRHVVY 287
Query: 760 ---------TLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP--PDRPKLSALLDMG 808
+L ++D LY C G Q + VL+ V P P + +L L++
Sbjct: 288 EDAQENFVLKILFCKQSDRGLYTCTASNLVG-QTYSSVLVVVREPAVPFKKRLQD-LEVR 345
Query: 809 QGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGL 868
+ A F+C V +P A F E L S ++ + E +L VR +
Sbjct: 346 EKESATFLCEV-PQPSTEAAWFKEETRLWAS--------AKYGIEEEGTERRLTVRNVSA 396
Query: 869 GDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSY 928
D Y CE S T V+G ++ P + C V VP G +
Sbjct: 397 DDDAVYICETPE---GSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFC-VELAVPVGPVH 452
Query: 929 RWYRDGQPL---------QESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLH 979
W R+ + + E T TL + L G A G TS +S
Sbjct: 453 -WLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMA---GDCQTSTQFCVS-- 506
Query: 980 VSYAPRHVTLTTLMD-TGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSS 1038
APR L +D R+ + S PP HG+R V T+ G +
Sbjct: 507 ---APRKPPLQPPVDPVVKARMESSVILSWSPPP------HGERPV--TIDGYLVEKKKL 555
Query: 1039 P-----RLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWP 1093
R H A T L + E + A N+ GQ S +F V + P
Sbjct: 556 GTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQ-SPYLEFPG---TVHLAP 611
Query: 1094 GATVR---------EGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSI-------PLP 1137
VR EG V + + + W+ DG Q L A S+
Sbjct: 612 KLAVRTPLKAVQAVEGGEVTFSVDLTVASAGE----WFLDG-QALKASSVYEIHCDRTRH 666
Query: 1138 NVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAP-----------------RNLRLTYL 1180
+T+R+ + G A + I ++V AP R L
Sbjct: 667 TLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQL 726
Query: 1181 LESHGGQLALVLCTVDSRP----PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDE 1236
L Q A V D R P + AGR + L +R D
Sbjct: 727 LAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRV-------------LLVRDVARDDA 773
Query: 1237 GFYSCSARSPLGQANTSLELRLEGVRVILAPEAA-----VPEGAPITVTCADPAAHAPTL 1291
G Y C +R + +L ++G+ L + A G P C AH
Sbjct: 774 GLYECVSRG----GRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPAQFECETSEAHVHV- 828
Query: 1292 YTWYHNG--------RWLQE--GPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQ 1341
WY +G R+LQE G L TR G YSC+ + R + +
Sbjct: 829 -HWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPK 887
Query: 1342 VLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGH 1401
V++A + + + A + A + C V ++ E+ DGK L++SS V A+G
Sbjct: 888 VVFAKEQLARRKLQ-AEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVCMEATG--- 942
Query: 1402 VQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAAL 1461
R + Q AG+ + Q L + V VA + GA+
Sbjct: 943 --CTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASA 1000
Query: 1462 NLSCRLLGGPGPVGNSTFAWFWNDRRL------HAEPV---PTLAFTHVARAQAGMYHCL 1512
LSC + V W+ + ++L H E L + AG Y C
Sbjct: 1001 TLSCEVAQAQTEV-----MWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCE 1055
Query: 1513 AELPTGAAASAPVMLRVLYP----PKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHL 1568
A L + P K ++ V+ E G +L C V ++ +T +
Sbjct: 1056 AR-----GQRVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEV-AQAQTEVTWYK 1109
Query: 1569 GSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSA 1615
+ ++SS G + L P A + +D GEY C A
Sbjct: 1110 DGKKLSSSSKVGMEVKGCTRRLVLPQAGK--------ADAGEYSCEA 1148
Score = 81.6 bits (200), Expect = 6e-15
Identities = 277/1174 (23%), Positives = 409/1174 (34%), Gaps = 187/1174 (15%)
Query: 255 GELVTLTCQVNSSYPAVSSIKW------LKDG----VRLQTKTGVLHLPQAAWSDAGVYT 304
G L C+++ V+ ++W L+DG +R + L + A +DAG Y
Sbjct: 3464 GATAMLWCELSK----VAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYL 3519
Query: 305 CQA--ENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYK 362
C E +L + F+ +V+ A E T L C + AP + W K
Sbjct: 3520 CVCGQERTSATLTIRALPAR-FIEDVKNQEAR---EGATAVLQCELNSAAPVE----WRK 3571
Query: 363 NHVLLEDAHSHTLR---------LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413
L D ++LR + ADTG Y C V G ER+ + V P
Sbjct: 3572 GSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAMLTVRALPIK 3627
Query: 414 TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSD-HSPRFSGTSGPN 472
E G +L C + H T D D HS R G
Sbjct: 3628 FTEGLRNEEATEGATAVLRCELSKMAPVEWWKGH------ETLRDGDRHSLRQDGAR--- 3678
Query: 473 SLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA-AEVVEGQAVTLSC 531
L+IR L D+GEY C +A T+ A ++ + E EG TL C
Sbjct: 3679 -CELQIRGLVAEDAGEYLCMCGKERTSAMLTV--RAMPSKFIEGLRNEEATEGDTATLWC 3735
Query: 532 R-SGLSPTPDARFSWYLNG----ALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGP 586
S +P + L +L +G L + + DAG Y C ++
Sbjct: 3736 ELSKAAPVEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTS--- 3792
Query: 587 SSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATS 646
A LTV P + F D+ A G +L C + P +
Sbjct: 3793 ---ATLTVRALPAR--FIE--DVKNQEAREGATAVLQCELSKAAPVEWRK---------- 3835
Query: 647 LPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNG 706
G T G R + + ++IH + + G Y C G TSAT
Sbjct: 3836 -----GSETLRG-GDRYSLRQDGTRCELQIHGLSVADTGEYSC----VCGQERTSATLTV 3885
Query: 707 QATVLAIA-PSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRNGV-LWAQGPLET---- 758
+A P +LQ EG+ A L C +S A W + G+ L A G E
Sbjct: 3886 RAPQPVFREPLQSLQAEEGSTATLQCELSEPTA----TVVWSKGGLQLQANGRREPRLQG 3941
Query: 759 ----VTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMAL 814
+ L + R D Y C G+Q ++ L P + ++ +G A
Sbjct: 3942 CTAELVLQDLQREDTGEYTCT----CGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAH 3997
Query: 815 FICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSY 874
C + SR A + G L ++Q + + +L VR + D+G Y
Sbjct: 3998 LCCEL-SRAGASVEWRKGSLQLFPC--------AKYQMVQDGAAAELLVRGVEQEDAGDY 4048
Query: 875 RCEATNVLGSSNTSLFFQV-RGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRD 933
C+ + S SL +V R + S E + G L CQ+ + G +W ++
Sbjct: 4049 TCDTGHT--QSMASLSVRVPRPKFKTRLQSLEQETGDIARLCCQL-SDAESGAVVQWLKE 4105
Query: 934 GQPLQESTSATLRFAAITLTQAGAYHCQAQAPGS---ATTSLAAPISLHVSYAPRHVTLT 990
G L +R T + + +A+ G T SL V+ VT+
Sbjct: 4106 GVELHAGPKYEMRSQGAT-RELLIHQLEAKDTGEYACVTGGQKTAASLRVTEP--EVTIV 4162
Query: 991 TLMDTGPGRLGLLLCRVDSDPPAQLRL---LHGDRLVASTLQGVGGPEGSSPRLHVAVAP 1047
GL+ V +D + G V LQG+ P S+ VAV
Sbjct: 4163 R---------GLVDAEVTADEDVEFSCEVSRAGATGVQWCLQGL--PLQSNEVTEVAVRD 4211
Query: 1048 NTLR-LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWP---GATVREGQLV 1103
+ L + G ED G S LG ++SA +A V + + EGQ
Sbjct: 4212 GRIHTLRLKGVTPEDAGT----VSFHLGNHASSAQLTVRAPEVTILEPLQDVQLSEGQDA 4267
Query: 1104 NLTCLV---------WTTHPAQLTYTWYQD-GQQRLDAHSIPLPNVTVRDATSYRCGVGP 1153
+ C + W L D ++ H + L VT+ DA + VG
Sbjct: 4268 SFQCRLSRASGQEARWALGGVPLQANEMNDITVEQGTLHLLTLHKVTLEDAGTVSFHVGT 4327
Query: 1154 PGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLA 1213
+L V+ N+ E+ G AL C + A +
Sbjct: 4328 CSSEAQLKVTAKNTVVRGLENV------EALEGGEALFECQLSQPEVAAHTWLLDDEPVH 4381
Query: 1214 SSTAASV---PNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRV-ILAP 1267
+S A V N LR L L+ +P+D SC G TS L + G R+ IL P
Sbjct: 4382 TSENAEVVFFENGLRHLLLLKNLRPQD----SCRVTFLAGDMVTSAFLTVRGWRLEILEP 4437
Query: 1268 --EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQ----------EGPAASLSFLVAT 1315
AAV GA TC A +WY NG +Q +G +L A
Sbjct: 4438 LKNAAVRAGAQACFTCTLSEAVPVGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSAQ 4497
Query: 1316 RAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDA 1349
HAG + +DA S+R L + P+DA
Sbjct: 4498 PHHAGEVTFACRDA--VASARLTVLGLPDPPEDA 4529
Score = 77.4 bits (189), Expect = 1e-13
Identities = 299/1338 (22%), Positives = 457/1338 (34%), Gaps = 238/1338 (17%)
Query: 225 RAQSEIHLQVKYAPKGVKILLSP-SGRNILPGELVTLTCQVNSSYPAVSSIKWLKDG--- 280
+++S L V P + L P +GR + + V L+C PA +++W KD
Sbjct: 2455 KSRSSARLVVSDIPVVLTRPLEPKTGREL---QSVVLSCDFR---PAPKAVQWYKDDTPL 2508
Query: 281 -------VRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPA 333
+ L+ + L + + +DAGVY CQA GS S S + + +V+
Sbjct: 2509 SPSEKFKMSLEGQMAELRILRLMPADAGVYRCQA----GSAHS---STEVTVEAREVTVT 2561
Query: 334 GPI-----LENQTVTLVCNTPNEAPSDLRYSWYKN---------HVLLEDAHSHTLRLHL 379
GP+ E + C +E D W N H + HTL L
Sbjct: 2562 GPLQDAEATEEGWASFSCELSHE---DEEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKS 2618
Query: 380 ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEP 439
RAD G V S R + V V L + G + L C VS+P
Sbjct: 2619 IQRADAGIVRASSLKVSTSAR---LEVRVKPVVFLKALDDLSAEERGTLA-LQCE-VSDP 2673
Query: 440 LATLVLSHGGHILA-STSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG 498
A +V G L S D H+ +GT G L + D+ D+G Y C +
Sbjct: 2674 EAHVVWRKDGVQLGPSDKYDFLHT---AGTRG-----LVVHDVSPEDAGLYTCHVGSEET 2725
Query: 499 NATSTL-DFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALL----- 552
A + D H + L EV+EG++ + C D W + G +
Sbjct: 2726 RARVRVHDLHVGITKRL--KTMEVLEGESCSFECVLSHESASDPAM-WTVGGKTVGSSSR 2782
Query: 553 ----HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLD 608
+G L++ A+ +DAG S G +S A L V R+
Sbjct: 2783 FQATRQGRKYILVVREAAPSDAGEV------VFSVRGLTSKASLIV----RERPAAIIKP 2832
Query: 609 LDAAGAGAGRRGLLLCRVD-SDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTK 667
L+ G L C + + P KDR S + V
Sbjct: 2833 LEDQWVAPGEDVELRCELSRAGTPVHWL---KDRKAIRK-------------SQKYDVVC 2876
Query: 668 APNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANL 727
+ + I L++ G Y CE + AS + ++GT A
Sbjct: 2877 EGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEELTNLQVEEKGT-AVF 2935
Query: 728 TCNVSREAAGSPANFSWFRNGVL----------WAQGPLETVTLLPVARTDAALYACRIL 777
TC A A +W R G+L +G +T+ + + D+ Y C I
Sbjct: 2936 TCKTEHPA----ATVTW-RKGLLELRASGKHQPSQEGLTLRLTISALEKADSDTYTCDI- 2989
Query: 778 TEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLA 837
AQ +L+ L +D+ +G A F C + A + H
Sbjct: 2990 --GQAQSRAQLLVQGRRVHIIEDLED-VDVQEGSSATFRCRISP------ANYEPVHWFL 3040
Query: 838 TSLGPQVPSHGRFQAKAEANS---LKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894
+ P H + +A L +R+L L DSG+ EA G S +V
Sbjct: 3041 ----DKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEA----GDQRASAALRVT 3092
Query: 895 ---GAWVQVSPSPELQEGQAVVLSCQVHT-GVPEGTSYRWYRDGQPLQ---------EST 941
+ + + EG+ + L C+ T +P W +DG+ L+ E
Sbjct: 3093 EKPSVFSRELTDATITEGEDLTLVCETSTCDIP----VCWTKDGKTLRGSARCQLSHEGH 3148
Query: 942 SATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLG 1001
A L TL +G Y C +A G+ ++S+ + V + L L G
Sbjct: 3149 RAQLLITGATLQDSGRYKC--EAGGACSSSIVRVHARPVRFQEALKDLEVL----EGGAA 3202
Query: 1002 LLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061
L C V S A ++ +G+ ++ + EG+ L L + +D
Sbjct: 3203 TLRC-VLSSVAAPVKWCYGNNVLRPGDKYSLRQEGA-----------MLELVVRNLRPQD 3250
Query: 1062 EGVYICE-----ASNTLGQASASADFDAQAVNVQVWPGATVR-EGQLVNLTCLVWTTHPA 1115
G Y C S TL + A F + N + GAT +L + W
Sbjct: 3251 SGRYSCSFGDQTTSATLTVTALPAQFIGKLRNKEATEGATATLRCELSKAAPVEWRKGSE 3310
Query: 1116 QL----TYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYA 1171
L Y QDG + + + + DA Y C G R S +T+ + A
Sbjct: 3311 TLRDGDRYCLRQDGAM----CELQIRGLAMVDAAEYSCVCG----EERTSASLTIRPMPA 3362
Query: 1172 PRNLRLTYLLESHGGQLALVLCTVDSRPPAQL-----ALSHAGRLLASSTAASVPNTLRL 1226
RL + ES G A + C + P + +L R A L
Sbjct: 3363 HFIGRLRH-QESIEGATATLRCELSKAAPVEWRKGRESLRDGDRHSLRQDGA----VCEL 3417
Query: 1227 ELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVI----LAPEAAVPEGAPITVTC- 1281
++ G D G YSC G+ TS L ++ + L E AV EGA + C
Sbjct: 3418 QICGLAVADAGEYSCVC----GEERTSATLTVKALPAKFTEGLRNEEAV-EGATAMLWCE 3472
Query: 1282 ---ADPAAHAPTLYTWYHNGRWL--QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSR 1336
P R++ QEG L A AG Y C R
Sbjct: 3473 LSKVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYLCVC------GQER 3526
Query: 1337 PAALQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHDGKVLATSSGVHS 1394
+A + A + ++ AR + AV+QC ++S P E G +
Sbjct: 3527 TSATLTIRALPARFIEDVKNQEAREGATAVLQCELNSAAPVE-----------WRKGSET 3575
Query: 1395 LASGTGH-VQVARNALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQVEGARVVAEPG 1452
L G + ++ LQ++ + D Y C + G T L V + G
Sbjct: 3576 LRDGDRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAMLTVRALPIKFTEG 3631
Query: 1453 L---DVPEGAALNLSCRL 1467
L + EGA L C L
Sbjct: 3632 LRNEEATEGATAVLRCEL 3649
Score = 69.3 bits (168), Expect = 3e-11
Identities = 313/1506 (20%), Positives = 499/1506 (33%), Gaps = 280/1506 (18%)
Query: 255 GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYT 304
G TL+C+V A + + W KDG +L + V L + QA + AG Y+
Sbjct: 1457 GASTTLSCEVAQ---AQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYS 1513
Query: 305 CQAENGVGSLVSPPISLHIFMAEVQV-----SPAGPILENQTVTLVCNTPNEAPSDLRYS 359
C+A S +S H+ +AE + PA ++ + T + A + +
Sbjct: 1514 CEAG-------SQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATLSCEVAQAQTEVT 1566
Query: 360 WYKNHVLLEDAH---------SHTLRLHLATRADTGFYFCEVQN------VHGSERSGPV 404
WYK+ L + + L + A +AD G Y C+ + +H +E P
Sbjct: 1567 WYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHVAE---PK 1623
Query: 405 SVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPR 464
V P + A +AG L C V G + +S+ +
Sbjct: 1624 VVFAKEQPAHREVQA----EAGASATLSCEVAQAQTEVTWYKDGKKLSSSS--------K 1671
Query: 465 FSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAA----- 519
+ + RL ++ + D+GEY C A G + H IS
Sbjct: 1672 VRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQRLSFRLHVAELEPQISERPCRREP 1727
Query: 520 -EVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH---------EGPGSSLLLPAASSTD 569
V E + + L+ L+ A +W +G + +G +L + A D
Sbjct: 1728 LVVKEHEDIILTAT--LATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLD 1785
Query: 570 AGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSD 629
+ Y CR A G P + + RL L+ G L C +
Sbjct: 1786 SAIYSCRV----GAEGQDFPVQVEEVAAK-----FCRL-LEPVCGELGGTVTLACELS-- 1833
Query: 630 PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLC 689
PA +++ R T L G R ++ + + + E+ G Y+C
Sbjct: 1834 -PACAEVVW--RCGNTQLRVG----------KRFQMVAEGPVRSLTVLGLRAEDAGEYVC 1880
Query: 690 EASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV 749
E+ + +A + + ++ + +EG EA C VS S WFR+G
Sbjct: 1881 ESRDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVVSP----SDVAVVWFRDGA 1936
Query: 750 LWAQGPLETVTLLPVARTDAALYACRILTEAGA------QLSTPVLLSVLYPPDRPKLSA 803
L P E + + + + +L +AG S+ L V P K
Sbjct: 1937 LLQ--PSEKFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKL 1994
Query: 804 LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
+ ++ + +RP L LA G V H AE +L +
Sbjct: 1995 EPQTVEERSSVTLEVELTRPWPELRWTRNATALAP--GKNVEIH------AEGARHRLVL 2046
Query: 864 RELGLGDSGSYRCEATNVLGSSNTSLFFQVRGA-WVQVSPSPELQEGQAVVLSCQVHTGV 922
+G D G + CE + + L ++R V+ + E +E + Q+
Sbjct: 2047 HNVGFADRGFFGCETPD--DKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQLSHAD 2104
Query: 923 PEGTSYRWYRDGQPLQESTSATL--RFAAITLTQAGAYHCQA-----QAPGSATTSLAAP 975
+G+ W RDG Q+ + L R TLT +G + +A G T++
Sbjct: 2105 VDGS---WTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKAEGVHTSARLVV 2161
Query: 976 ISLHVSYA-PRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034
L VS++ P +TT + L C + S P +R L GV
Sbjct: 2162 TELPVSFSRPLQDVVTTEKEKVT-----LECEL-SRPNVDVRWLK---------DGVELR 2206
Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASA---------------- 1078
G + + +A L I+ D+GVY+C+A + AS
Sbjct: 2207 AGKT--MAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLA 2264
Query: 1079 -----------SADFDAQAVNVQVWPGATVR--------EGQLVNLTCLVWTTHPAQLTY 1119
+A+ AQ + V+ P VR E L C V A
Sbjct: 2265 EDAGEIQFVAENAESRAQ-LRVKELPVTLVRPLRDKIAMEKHRGVLECQV---SRASAQV 2320
Query: 1120 TWYQDGQQRLDA-----------HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV 1168
W++ Q+ + + +V D +Y C G + + +
Sbjct: 2321 RWFKGSQELQPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDAGDVKTSAQFF--VEEQS 2378
Query: 1169 LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLEL 1228
+ R L+ ++E RPP + L T + LE
Sbjct: 2379 ITIVRGLQDVTVMEPAPAWFECETSIPSVRPP---------KWLLGKTVLQAGGNVGLEQ 2429
Query: 1229 RGPQPRDEGFYSCSARS-----PLGQANTSLELRLEGVRVILAPEAAVPEGAPI-TVTCA 1282
G R +CS + +G++ +S L + + V+L G + +V +
Sbjct: 2430 EGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPLEPKTGRELQSVVLS 2489
Query: 1283 DPAAHAPTLYTWYHNGRWLQ---------EGPAASLSFLVATRAHAGAYSCQAQDAQGTR 1333
AP WY + L EG A L L A AG Y CQA A +
Sbjct: 2490 CDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHSST 2549
Query: 1334 SSRPAALQVLYAPQDAVLSSFRDSRA--RSMAVIQCTVDSEPPAELALSHDGKVLATSSG 1391
A +V V +D+ A A C + E E+ S +G L S
Sbjct: 2550 EVTVEAREV------TVTGPLQDAEATEEGWASFSCELSHE-DEEVEWSLNGMPLYNDSF 2602
Query: 1392 VHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEP 1451
G H V ++ R D + A +L +ST RL+V VV
Sbjct: 2603 HEISHKGRRHTLVLKSIQRA---------DAGIVRASSL--KVSTSARLEVRVKPVVFLK 2651
Query: 1452 GLD---VPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQ--- 1505
LD E L L C + V W + P F H A +
Sbjct: 2652 ALDDLSAEERGTLALQCEVSDPEAHV-------VWRKDGVQLGPSDKYDFLHTAGTRGLV 2704
Query: 1506 --------AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVD 1557
AG+Y C A L V + TM V +L
Sbjct: 2705 VHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHESA 2764
Query: 1558 SEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASN 1617
S+P A T +G + V SS A + ++L + PSD GE + S
Sbjct: 2765 SDP-AMWT--VGGKTVGSSSRFQATRQGRKYILV--------VREAAPSDAGEVVFSVRG 2813
Query: 1618 VLGSAS 1623
+ AS
Sbjct: 2814 LTSKAS 2819
Score = 68.9 bits (167), Expect = 4e-11
Identities = 266/1211 (21%), Positives = 410/1211 (33%), Gaps = 218/1211 (18%)
Query: 509 NAARLLISPAAEVV----------EGQAVTLSCRSGLSPTPDARFSWYLNGALLH----- 553
++ARL++S V+ E Q+V LSC P P A WY + L
Sbjct: 2458 SSARLVVSDIPVVLTRPLEPKTGRELQSVVLSC--DFRPAPKA-VQWYKDDTPLSPSEKF 2514
Query: 554 ----EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDL 609
EG + L + DAG Y C+A HS++ V R+ T T L
Sbjct: 2515 KMSLEGQMAELRILRLMPADAGVYRCQAGSAHSST--------EVTVEAREVTVTGPLQ- 2565
Query: 610 DAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAP 669
DA G +L H+D V SL G +
Sbjct: 2566 DAEATEEGWASF-----------SCELSHEDEEVEWSL---NGMPLYNDSFHEISHKGRR 2611
Query: 670 NLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTC 729
+ L ++ + + G+ + +A + A+ + GT A L C
Sbjct: 2612 HTLVLK--SIQRADAGIVRASSLKVSTSARLEVRVKPVVFLKALDDLSAEERGTLA-LQC 2668
Query: 730 NVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVART-----------DAALYACRILT 778
VS A+ W ++GV GP + L A T DA LY C + +
Sbjct: 2669 EVS----DPEAHVVWRKDGV--QLGPSDKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGS 2722
Query: 779 EAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLAT 838
E + V + L+ +L + ++ +G F C + + A++ T
Sbjct: 2723 E---ETRARVRVHDLHVGITKRLKTM-EVLEGESCSFECVLSHESASDPAMW-------T 2771
Query: 839 SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV 898
G V S RFQA + L VRE D+G + +S SL + R A +
Sbjct: 2772 VGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGEVVFSVRGL--TSKASLIVRERPAAI 2829
Query: 899 QVSPSPE--LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQ---------ESTSATLRF 947
+ P + + G+ V L C++ GT W +D + ++ E T A L
Sbjct: 2830 -IKPLEDQWVAPGEDVELRCELSRA---GTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVI 2885
Query: 948 AAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVT--LTTLMDTGPGRLGLLLC 1005
+L AG Y C+ +A S SLHV T LT L G + C
Sbjct: 2886 RGASLKDAGEYTCEVEASKSTA-------SLHVEEKANCFTEELTNLQVEEKG-TAVFTC 2937
Query: 1006 RVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVY 1065
+ + P A + G L+ G + S L TLRL I D Y
Sbjct: 2938 KTE-HPAATVTWRKG----LLELRASGKHQPSQEGL-------TLRLTISALEKADSDTY 2985
Query: 1066 ICEASNTLGQASASADFDAQAVNVQV---WPGATVREGQLVNLTCLVWTTHPAQL-TYTW 1121
C+ +GQA + A Q V + V+EG C + PA W
Sbjct: 2986 TCD----IGQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSATFRCRI---SPANYEPVHW 3038
Query: 1122 YQDGQ-------QRLDA-----HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVL 1169
+ D +DA H + L + ++D+ + G R S + +
Sbjct: 3039 FLDKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEAGD----QRASAALRVTEK 3094
Query: 1170 YAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVP---NTLRL 1226
+ + LT + G L LV T P + + G+ L S + + +L
Sbjct: 3095 PSVFSRELTDATITEGEDLTLVCETSTCDIP--VCWTKDGKTLRGSARCQLSHEGHRAQL 3152
Query: 1227 ELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAA 1286
+ G +D G Y C A + + R + L + V EG T+ C +
Sbjct: 3153 LITGATLQDSGRYKCEAGGACSSSIVRVHARPVRFQEAL-KDLEVLEGGAATLRCVLSSV 3211
Query: 1287 HAPTLYTWYHN-------GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAA 1339
AP + + +N QEG L +G YSC D + A
Sbjct: 3212 AAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSFGD-----QTTSAT 3266
Query: 1340 LQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLAS 1397
L V P + R+ A + A ++C + P E G +L
Sbjct: 3267 LTVTALPAQ-FIGKLRNKEATEGATATLRCELSKAAPVE-----------WRKGSETLRD 3314
Query: 1398 GTGHVQVARNAL-RLQVQD---VPAGDDTYVCTAQNLLGSIST-------IGRLQVEGAR 1446
G + A+ LQ++ V A + + VC + S++ IGRL+ +
Sbjct: 3315 GDRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFIGRLRHQ--- 3371
Query: 1447 VVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA----EPVPTLAFTHVA 1502
+ EGA L C L PV D H+ V L +A
Sbjct: 3372 -------ESIEGATATLRCE-LSKAAPVEWRKGRESLRDGDRHSLRQDGAVCELQICGLA 3423
Query: 1503 RAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLA 1562
A AG Y C+ G ++ + P K + E G +L C + +A
Sbjct: 3424 VADAGEYSCVC----GEERTSATLTVKALPAKFTEGLRNEEAVEGATAMLWCELSK--VA 3477
Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
+ G P+ + + I L +D GEY+C V G
Sbjct: 3478 PVEWRKG--------PENLRDGDRYILRQEGTRCELQICGLAMADAGEYLC----VCGQE 3525
Query: 1623 STSTYFGVRAL 1633
TS +RAL
Sbjct: 3526 RTSATLTIRAL 3536
Score = 67.8 bits (164), Expect = 9e-11
Identities = 122/500 (24%), Positives = 189/500 (37%), Gaps = 80/500 (16%)
Query: 138 EPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVG 197
EP+V A + + ST C Q + + + ++F+S K VG
Sbjct: 1437 EPKV-VFAKEQPVHREVQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSFSS-KVRMEAVG 1494
Query: 198 HLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILP--G 255
L + Q G+ + + S + HL V PK V P+ R + G
Sbjct: 1495 CTRRLVV----QQAGQAVAGEYSCEAGSQRLSFHLHVA-EPKAVFAKEQPASREVQAEAG 1549
Query: 256 ELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTC 305
TL+C+V A + + W KDG +L + + V L + +A +DAG Y+C
Sbjct: 1550 TSATLSCEVAQ---AQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSC 1606
Query: 306 QAENGVGSLVSPPISLHIFMAEVQV-----SPAGPILENQ---TVTLVCNTPNEAPSDLR 357
+A + +S H+ +AE +V PA ++ + + TL C A +
Sbjct: 1607 KAGD-------QRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEV---AQAQTE 1656
Query: 358 YSWYKNHVLLEDAH---------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVV 408
+WYK+ L + + L + A +AD G Y CE G +R +S +
Sbjct: 1657 VTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQR---LSFRL 1709
Query: 409 NHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSG-DSDHSPRFSG 467
+ L P ++ + LV H ++ ATL + G + S R
Sbjct: 1710 HVAELEPQISERPCRREPLVVKEHEDIILT--ATLATPSAATVTWLKDGVEIRRSKRHET 1767
Query: 468 TSGPNSLRLEIRDLEETDSGEYKCSA-TNSLGNATSTLDFHANAARLLISPAAEVVEGQA 526
S ++ L + + DS Y C + A RLL E+ G
Sbjct: 1768 ASQGDTHTLTVHGAQVLDSAIYSCRVGAEGQDFPVQVEEVAAKFCRLLEPVCGEL--GGT 1825
Query: 527 VTLSCRSGLSPTPDARFSWYLNGALLH---------EGPGSSLLLPAASSTDAGSYHCRA 577
VTL+C LSP A W L EGP SL + + DAG Y C +
Sbjct: 1826 VTLACE--LSPAC-AEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCES 1882
Query: 578 RDGHSASGPSSPAVLTVLYP 597
RD H++ A LTV P
Sbjct: 1883 RDDHTS------AQLTVSVP 1896
Score = 58.5 bits (140), Expect = 5e-08
Identities = 219/971 (22%), Positives = 342/971 (35%), Gaps = 172/971 (17%)
Query: 172 RLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIH 231
R Q + P RS+T + E G ++ S DH QL+V+
Sbjct: 1853 RFQMVAEGPVRSLTVLGLRAEDAGE------YVCESRDDH---TSAQLTVS--------- 1894
Query: 232 LQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ------- 284
P+ VK + S G T C V+ P+ ++ W +DG LQ
Sbjct: 1895 -----VPRVVKFMSGLSTVVAEEGGEATFQCVVS---PSDVAVVWFRDGALLQPSEKFAI 1946
Query: 285 TKTGVLH---LPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQT 341
+++G H + DAG T +AE G S + + + + ++ P + E +
Sbjct: 1947 SQSGASHSLTISDLVLEDAGQITVEAE-GASSSAALRVREAPVLFKKKLEPQ-TVEERSS 2004
Query: 342 VTLVCNTPNEAPSDLRYSWY-------KNHVLLEDAHSHTLRLHLATRADTGFYFCEVQN 394
VTL P +LR++ KN + + H L LH AD GF+ CE +
Sbjct: 2005 VTLEVELTRPWP-ELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCETPD 2063
Query: 395 VHGSERSGPVSVVVNHPPLTPVLTAFLETQAGL----VGILHCSVVSEPLATLVLSHGGH 450
+ ++V + L L A + G V + H V + G
Sbjct: 2064 ---DKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQLSHADVDGS------WTRDG- 2113
Query: 451 ILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG--EYKCSATNSLGNATSTLDFHA 508
L G + H GP L + L DSG +K ++ T +
Sbjct: 2114 -LRFQQGPTCHL----AVRGPMHT-LTLSGLRPEDSGLMVFKAEGVHTSARLVVT-ELPV 2166
Query: 509 NAARLLISPAAEVV--EGQAVTLSCRSGLSPTPDARFSWYLNG---------ALLHEGPG 557
+ +R P +VV E + VTL C P D R W +G A+ +G
Sbjct: 2167 SFSR----PLQDVVTTEKEKVTLECELS-RPNVDVR--WLKDGVELRAGKTMAIAAQGAC 2219
Query: 558 SSLLLPAASSTDAGSYHCRARDGHS-ASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGA 616
SL + D G Y C A D S AS T++Y R+ ++ A
Sbjct: 2220 RSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIY--RRVLAEDAGEIQFVAENA 2277
Query: 617 GRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCS--------------PR 662
R L RV P ++ L +D++ C + P+
Sbjct: 2278 ESRAQL--RVKELPVTLVRPL-RDKIAMEKHRGVLECQVSRASAQVRWFKGSQELQPGPK 2334
Query: 663 MKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATF---NGQATVLAIAPSHTL 719
++ ++ I + E+E Y C+A G+ TSA F T++ T+
Sbjct: 2335 YELVSDGLYRKLIISDVHAEDEDTYTCDA----GDVKTSAQFFVEEQSITIVRGLQDVTV 2390
Query: 720 QEGTEANLTCNVSREAAGSPANFSWFRNG-VLWAQGPLE-----TVTLLPVARTDAALYA 773
E A C S + P W VL A G + TV L + RT + +
Sbjct: 2391 MEPAPAWFECETSIPSVRPP---KWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTG 2447
Query: 774 CRILTEAGAQLSTPVLLS----VLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLAL 829
T ++ S +++S VL P PK L + + D RP
Sbjct: 2448 PVHFTVGKSRSSARLVVSDIPVVLTRPLEPKTGRELQS-------VVLSCDFRPAPKAVQ 2500
Query: 830 FHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSL 889
++ + P PS +F+ E +L + L D+G YRC+A GS+++S
Sbjct: 2501 WYKDDT------PLSPSE-KFKMSLEGQMAELRILRLMPADAGVYRCQA----GSAHSST 2549
Query: 890 FFQVRGAWVQVSPSPELQEGQA-----VVLSCQVHTGVPEGTSYRWYRDGQPLQEST--S 942
V +V+ + LQ+ +A SC++ E W +G PL +
Sbjct: 2550 EVTVEAR--EVTVTGPLQDAEATEEGWASFSCELS---HEDEEVEWSLNGMPLYNDSFHE 2604
Query: 943 ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL 1002
+ + TL A +++ ++ L V P V L L D G
Sbjct: 2605 ISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKP-VVFLKALDDLSAEERGT 2663
Query: 1003 LLCRVD-SDPPAQLRLLHGDRLVASTLQGVG-GPEGSSPRLHVAVAPNTLRLEIHGAMLE 1060
L + + SDP A V GV GP LH A T L +H E
Sbjct: 2664 LALQCEVSDPEAH---------VVWRKDGVQLGPSDKYDFLHTA---GTRGLVVHDVSPE 2711
Query: 1061 DEGVYICEASN 1071
D G+Y C +
Sbjct: 2712 DAGLYTCHVGS 2722
Score = 57.8 bits (138), Expect = 9e-08
Identities = 79/348 (22%), Positives = 119/348 (34%), Gaps = 82/348 (23%)
Query: 1339 ALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASG 1398
A + L P+ V+S +D A + C + P +++ D + +A + G
Sbjct: 9 APRFLTRPKAFVVSVGKD------ATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDG 62
Query: 1399 TGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQVEGARVVAEPG----- 1452
+ RL + D+ GD YVC A+N +G LQV+ AE
Sbjct: 63 --------DLYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLL 114
Query: 1453 ----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQA-- 1506
+ V EG+ CR+ G P P +W + RRL P + + A A
Sbjct: 115 RPTSIRVREGSEATFRCRVGGSPRPA----VSWSKDGRRLGEPDGPRVRVEELGEASALR 170
Query: 1507 ---------GMYHCLAELPTGAAASAPVML------------------------------ 1527
G Y AE P GAA++A ++
Sbjct: 171 IRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAM 230
Query: 1528 ----RVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPA 1583
PP T T V G L C V EP +LV +
Sbjct: 231 RAEGAPASPPSTGTRTCTVTE--GKHARLSCYVTGEPKPETVWKKDGQLVTEGR------ 282
Query: 1584 EPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
H+ + + I + SD+G Y C+ASN++G +S VR
Sbjct: 283 -RHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVR 329
Score = 54.3 bits (129), Expect = 1e-06
Identities = 54/192 (28%), Positives = 78/192 (40%), Gaps = 24/192 (12%)
Query: 909 GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST----------SATLRFAAITLTQAGAY 958
G+ V L+C+V TG P+ WY+DG+ +Q S L ++T +G Y
Sbjct: 6028 GETVKLACRV-TGTPKPV-ISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQY 6085
Query: 959 HCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLL 1018
C A + ++L + V PR V G C ++ P Q+R
Sbjct: 6086 MCFAASAAGNCSTLG---KILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWY 6142
Query: 1019 HGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASA 1078
L+ + G S PR + V L I A ED G+Y CE N LG A A
Sbjct: 6143 KDGALLTT---GNKFQTLSEPRSGLLV------LVIRAASKEDLGLYECELVNRLGSARA 6193
Query: 1079 SADFDAQAVNVQ 1090
SA+ Q+ +Q
Sbjct: 6194 SAELRIQSPMLQ 6205
Score = 50.4 bits (119), Expect = 1e-05
Identities = 55/222 (24%), Positives = 83/222 (37%), Gaps = 26/222 (11%)
Query: 718 TLQEGTEANLTCNVSREAAGSPAN-FSWFRNGVLWAQGPLETVTLLP----------VAR 766
T + G L C V+ G+P SW+++G P + P +
Sbjct: 6024 TAELGETVKLACRVT----GTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTG 6079
Query: 767 TDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLAL 826
D+ Y C + AG ST + V PP +G A F CT++ P
Sbjct: 6080 VDSGQYMCFAASAAG-NCSTLGKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQ 6138
Query: 827 LALFHGEHLLATSLGPQVPSHGRFQAKAEANS--LKLEVRELGLGDSGSYRCEATNVLGS 884
+ + LL T +FQ +E S L L +R D G Y CE N LGS
Sbjct: 6139 IRWYKDGALLTTG--------NKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGS 6190
Query: 885 SNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGT 926
+ S +++ +Q ++ A V + T VP+ T
Sbjct: 6191 ARASAELRIQSPMLQAQEQCHREQLVAAVEVTEQETKVPKKT 6232
Score = 49.3 bits (116), Expect = 3e-05
Identities = 57/198 (28%), Positives = 86/198 (43%), Gaps = 31/198 (15%)
Query: 524 GQAVTLSCRSGLSPTPDARFSWYLNGA--------LLHEGPGSS--LLLPAASSTDAGSY 573
G+ V L+CR ++ TP SWY +G +L E P S L+L + + D+G Y
Sbjct: 6028 GETVKLACR--VTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQY 6085
Query: 574 HCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPAR 633
C A +A S+ + V PPR F ++ A+ G C ++ P +
Sbjct: 6086 MCFAAS--AAGNCSTLGKILVQVPPR---FVNKVR--ASPFVEGEDAQFTCTIEGAPYPQ 6138
Query: 634 LQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASN 693
++ +KD + T+ G T PR LL + I E+ GLY CE N
Sbjct: 6139 IRW-YKDGALLTT---GNKFQTLS--EPRS------GLLVLVIRAASKEDLGLYECELVN 6186
Query: 694 ALGNASTSATFNGQATVL 711
LG+A SA Q+ +L
Sbjct: 6187 RLGSARASAELRIQSPML 6204
Score = 46.6 bits (109), Expect = 2e-04
Identities = 49/182 (26%), Positives = 72/182 (39%), Gaps = 23/182 (12%)
Query: 1096 TVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ-RLDAHSIP-----------LPNVTVRD 1143
T G+ V L C V T + +WY+DG+ ++D H I L ++T D
Sbjct: 6024 TAELGETVKLACRV--TGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVD 6081
Query: 1144 ATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQ 1202
+ Y C G L + + V PR + G+ A CT++ P Q
Sbjct: 6082 SGQYMCFAASAAGNCSTLGKIL---VQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQ 6138
Query: 1203 LALSHAGRLLASST---AASVPNT--LRLELRGPQPRDEGFYSCSARSPLGQANTSLELR 1257
+ G LL + S P + L L +R D G Y C + LG A S ELR
Sbjct: 6139 IRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELR 6198
Query: 1258 LE 1259
++
Sbjct: 6199 IQ 6200
Score = 40.8 bits (94), Expect = 0.011
Identities = 49/186 (26%), Positives = 73/186 (39%), Gaps = 22/186 (11%)
Query: 340 QTVTLVCNTPNEAPSDLRYSWYKN---------HVLLEDAH-SHTLRLHLATRADTGFYF 389
+TV L C + SWYK+ H+L+ED S L L T D+G Y
Sbjct: 6029 ETVKLACRVTGTPKPVI--SWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYM 6086
Query: 390 CEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGG 449
C + G+ S ++V PP G C++ P + G
Sbjct: 6087 CFAASAAGN-CSTLGKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDG 6145
Query: 450 HILASTSGDSDHSPRFSGTSGPNS--LRLEIRDLEETDSGEYKCSATNSLGNATSTLDFH 507
+L T+G+ +F S P S L L IR + D G Y+C N LG+A ++ +
Sbjct: 6146 ALL--TTGN-----KFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELR 6198
Query: 508 ANAARL 513
+ L
Sbjct: 6199 IQSPML 6204
Score = 40.0 bits (92), Expect = 0.019
Identities = 88/430 (20%), Positives = 139/430 (32%), Gaps = 101/430 (23%)
Query: 639 KDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEE-------------- 684
+++ V P C G P ++ K LL + H + E++
Sbjct: 5133 QNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPA 5192
Query: 685 --GLYLCEASNALGNASTSATFNGQAT-----VLAIAP------------SHTLQEGTEA 725
G+Y C A N++G +ST A T A A S QEGTE+
Sbjct: 5193 DMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTES 5252
Query: 726 NLT----------------------CNVSREAAGSPA-NFSWFRNGV---------LWAQ 753
+ G PA WF++G + +
Sbjct: 5253 TTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDK 5312
Query: 754 GPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQ---- 809
L T+ ++ V R D+ YA I GA S+ LL + PD P+ D+ +
Sbjct: 5313 KILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLL--VRGPDEPEEKPASDVHEQLVP 5370
Query: 810 --------------GHMALFICTVDSRPLALLALFHGEHLLATS-LGPQVPSHGRFQAKA 854
G F V+ RP+ + E +GP P + +
Sbjct: 5371 PRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPG---YTVAS 5427
Query: 855 EANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVL 914
A L + ++G G+Y C A+N G + S V G P E QE L
Sbjct: 5428 SAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGL-----PKVEEQEKVKEAL 5482
Query: 915 SCQVHTGVPEGTSYRWYR-------DGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGS 967
G + S + GQ +E +A ++L + G +
Sbjct: 5483 ISTFLQGTTQAISAQGLETASFADLGGQRKEEPLAAKEALGHLSLAEVGTEEFLQKLTSQ 5542
Query: 968 ATTSLAAPIS 977
T ++A I+
Sbjct: 5543 ITEMVSAKIT 5552
Score = 40.0 bits (92), Expect = 0.019
Identities = 42/188 (22%), Positives = 70/188 (37%), Gaps = 27/188 (14%)
Query: 1458 GAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVP----------TLAFTHVARAQAG 1507
G + L+CR+ G P PV +W+ + + + +P L + +G
Sbjct: 6028 GETVKLACRVTGTPKPV----ISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSG 6083
Query: 1508 MYHCLAELPTGAAASAPVMLRVLYPPKTPTMM---VFVEPEGGLRGILDCRVDSEPLASL 1564
Y C A G ++ +L V PP+ + FVE E C ++ P +
Sbjct: 6084 QYMCFAASAAGNCSTLGKIL-VQVPPRFVNKVRASPFVEGEDAQ---FTCTIEGAPYPQI 6139
Query: 1565 TLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSAST 1624
+ L+ + +EP +L + I A D G Y C N LGSA
Sbjct: 6140 RWYKDGALLTTGNKFQTLSEPRSGLLV------LVIRAASKEDLGLYECELVNRLGSARA 6193
Query: 1625 STYFGVRA 1632
S +++
Sbjct: 6194 SAELRIQS 6201
Score = 36.2 bits (82), Expect = 0.28
Identities = 42/191 (21%), Positives = 75/191 (39%), Gaps = 25/191 (13%)
Query: 1274 GAPITVTCADPAAHAPTLYTWYHNGRWLQ--------EGPAASLSFLV--ATRAHAGAYS 1323
G + + C P + +WY +G+ +Q E P S + ++ T +G Y
Sbjct: 6028 GETVKLACRVTGTPKPVI-SWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYM 6086
Query: 1324 CQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSR--ARSMAVIQCTVDSEPPAELALSH 1381
C A A G S+ ++L ++ R S A CT++ P ++
Sbjct: 6087 CFAASAAGNCSTLG---KILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYK 6143
Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD--TYVCTAQNLLGSISTIGR 1439
DG +L T + +L+ R+ L + V + +D Y C N LGS
Sbjct: 6144 DGALLTTGNKFQTLSE-------PRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAE 6196
Query: 1440 LQVEGARVVAE 1450
L+++ + A+
Sbjct: 6197 LRIQSPMLQAQ 6207
Score = 34.3 bits (77), Expect = 1.1
Identities = 74/336 (22%), Positives = 111/336 (33%), Gaps = 73/336 (21%)
Query: 520 EVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP----------GSSLLLPAASSTD 569
EV +G V+ C P P R W+ +G LL E G L++ A D
Sbjct: 5136 EVQDGYPVSFDCVVTGQPMPSVR--WFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPAD 5193
Query: 570 AGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRV--- 626
G Y C A + S S+ A L V + T D + + +G L R
Sbjct: 5194 MGVYRCLAENSMGVS--STKAELRV--DLTSTDYDTAADATESSSYFSAQGYLSSREQEG 5249
Query: 627 ------DSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRM---------------KV 665
+ P ++ L +V + + G +PR+ ++
Sbjct: 5250 TESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRM 5309
Query: 666 TKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATF-----------NGQATVLAIA 714
T L +EI + E+ G Y SNA+G A +SA +
Sbjct: 5310 TDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLV 5369
Query: 715 PSHTLQEGTE------ANLTCNVSREAAGSPANFSWFR----NGVLW-----------AQ 753
P L+ T +++T +V E P W R GVLW +
Sbjct: 5370 PPRMLERFTPKKVKKGSSITFSVKVEGRPVP-TVHWLREEAERGVLWIGPDTPGYTVASS 5428
Query: 754 GPLETVTLLPVARTDAALYACRILTEAGAQLSTPVL 789
++ LL V R Y C AG L + L
Sbjct: 5429 AQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASL 5464
Score = 33.5 bits (75), Expect = 1.8
Identities = 74/337 (21%), Positives = 114/337 (33%), Gaps = 79/337 (23%)
Query: 255 GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAA------------WSDAGV 302
G+ + L C V S A +WLKDGV L T H+ Q +DAG
Sbjct: 4912 GDALRLECVVASK--ADVRARWLKDGVEL-TDGRHHHIDQLGDGTCSLLITGLDRADAGC 4968
Query: 303 YTCQAENGVGSLV-SPPISLHIFMAEVQVSPAG-----------------------PILE 338
YTCQ N G + S + + +E + S G + +
Sbjct: 4969 YTCQVSNKFGQVTHSACVVVSGSESEAESSSGGELDDAFRRAARRLHRLFRTKSPAEVSD 5028
Query: 339 NQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRA-----------DTGF 387
+ P E + Y+ ED H +R T A T
Sbjct: 5029 EELFLSADEGPAEPEEPADWQTYR-----EDEHFICIRFEALTEARQAVTRFQEMFATLG 5083
Query: 388 YFCEVQNVHGSERSGPVSV-------VVNHPPLTPVLTA-----FL------ETQAGLVG 429
E++ V R + + VV PL +LT+ FL E Q G
Sbjct: 5084 IGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPV 5143
Query: 430 ILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEY 489
C V +P+ ++ G +L + DH G + +L I + D G Y
Sbjct: 5144 SFDCVVTGQPMPSVRWFKDGKLLE----EDDHYMINEDQQGGH--QLIITAVVPADMGVY 5197
Query: 490 KCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQA 526
+C A NS+G +++ + + AA+ E +
Sbjct: 5198 RCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSS 5234
Score = 33.1 bits (74), Expect = 2.4
Identities = 30/94 (31%), Positives = 44/94 (46%), Gaps = 21/94 (22%)
Query: 234 VKYAPKGV-KILLSPSGRNILPGELVTLTCQVNSS-YPAVSSIKWLKDGVRLQT------ 285
V+ P+ V K+ SP + GE TC + + YP I+W KDG L T
Sbjct: 6104 VQVPPRFVNKVRASP----FVEGEDAQFTCTIEGAPYP---QIRWYKDGALLTTGNKFQT 6156
Query: 286 ----KTG--VLHLPQAAWSDAGVYTCQAENGVGS 313
++G VL + A+ D G+Y C+ N +GS
Sbjct: 6157 LSEPRSGLLVLVIRAASKEDLGLYECELVNRLGS 6190
>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform b [Homo sapiens]
Length = 7968
Score = 119 bits (297), Expect = 3e-26
Identities = 374/1644 (22%), Positives = 572/1644 (34%), Gaps = 315/1644 (19%)
Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFN 159
L++ D+ PED+G Y E V V +T+ + +E+LEG F
Sbjct: 2703 LVVHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKT------MEVLEGESCSFE 2756
Query: 160 CSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHM-AMSWQDHGRILRCQ 218
C + + G+ +S +F+ T G L + + D G ++
Sbjct: 2757 CVLSHESASDPAMWTVGGK-----TVGSSSRFQATRQGRKYILVVREAAPSDAGEVV--- 2808
Query: 219 LSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLK 278
SV S+ L V+ P I+ + + PGE V L C+++ A + + WLK
Sbjct: 2809 FSVRG--LTSKASLIVRERP--AAIIKPLEDQWVAPGEDVELRCELSR---AGTPVHWLK 2861
Query: 279 D--GVRLQTKTGV--------LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHI----- 323
D +R K V L + A+ DAG YTC+ E + SLH+
Sbjct: 2862 DRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKST-----ASLHVEEKAN 2916
Query: 324 ----FMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH------ 373
+ +QV G T C T + A + +W K + L + H
Sbjct: 2917 CFTEELTNLQVEEKG------TAVFTCKTEHPAAT---VTWRKGLLELRASGKHQPSQEG 2967
Query: 374 -TLRLHLAT--RADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGI 430
TLRL ++ +AD+ Y C++ G +S +V ++ Q G
Sbjct: 2968 LTLRLTISALEKADSDTYTCDI----GQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSAT 3023
Query: 431 LHCSVVS---EPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
C + EP+ + H A+ + D P G + L L R L DSG
Sbjct: 3024 FRCRISPANYEPVHWFLDKTPLH--ANELNEIDAQP-----GGYHVLTL--RQLALKDSG 3074
Query: 488 EYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYL 547
A + +A + + ++ A + EG+ +TL C + T D W
Sbjct: 3075 TIYFEAGDQRASAALRVTEKPSVFSRELTDAT-ITEGEDLTLVCETS---TCDIPVCWTK 3130
Query: 548 NGALL---------HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
+G L HEG + LL+ A+ D+G Y C A G S +++ V
Sbjct: 3131 DGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKC------EAGGACSSSIVRV--HA 3182
Query: 599 RQPTFTTRL-DLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCG 657
R F L DL+ GA L C V S A ++ + + V+
Sbjct: 3183 RPVRFQEALKDLEVLEGGA---ATLRC-VLSSVAAPVKWCYGNNVLRP------------ 3226
Query: 658 GCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNG---QATVLAIA 714
+ + + +L + + N ++ G Y C + G+ +TSAT A +
Sbjct: 3227 --GDKYSLRQEGAMLELVVRNLRPQDSGRYSC----SFGDQTTSATLTVTALPAQFIGKL 3280
Query: 715 PSHTLQEGTEANLTCNVSREAAGSPANFS-WFRNG---VLWAQGPLETVTLLPVARTDAA 770
+ EG A L C +S+ A S R+G L G + + + +A DAA
Sbjct: 3281 RNKEATEGATATLRCELSKAAPVEWRKGSETLRDGDRYCLRQDGAMCELQIRGLAMVDAA 3340
Query: 771 LYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALF 830
Y+C G + ++ L P + +G A C + A +
Sbjct: 3341 EYSC----VCGEERTSASLTIRPMPAHFIGRLRHQESIEGATATLRCELSK--AAPVEWR 3394
Query: 831 HGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLF 890
G L R + + +L++ L + D+G Y C V G TS
Sbjct: 3395 KGRESLRDG--------DRHSLRQDGAVCELQICGLAVADAGEYSC----VCGEERTSAT 3442
Query: 891 FQVR---GAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRW------YRDGQPL---Q 938
V+ + + + E EG +L C++ P W RDG Q
Sbjct: 3443 LTVKALPAKFTEGLRNEEAVEGATAMLWCELSKVAP----VEWRKGPENLRDGDRYILRQ 3498
Query: 939 ESTSATLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP 997
E T L+ + + AG Y C Q SAT ++ A R + +
Sbjct: 3499 EGTRCELQICGLAMADAGEYLCVCGQERTSATLTIRA-------LPARFIEDVKNQEARE 3551
Query: 998 GRLGLLLCRVDSDPPAQLR-----LLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRL 1052
G +L C ++S P + R L GDR +L+ G L
Sbjct: 3552 GATAVLQCELNSAAPVEWRKGSETLRDGDRY---SLRQDG---------------TKCEL 3593
Query: 1053 EIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG---ATVREGQLVNLTCLV 1109
+I G + D G Y C GQ SA +A+ ++ G EG L C +
Sbjct: 3594 QIRGLAMADTGEYSC----VCGQERTSAMLTVRALPIKFTEGLRNEEATEGATAVLRCEL 3649
Query: 1110 WTTHPAQLTYTWYQDGQQRL---DAHS---------IPLPNVTVRDATSYRCGVGPPGRA 1157
P + W++ G + L D HS + + + DA Y C G +
Sbjct: 3650 SKMAPVE----WWK-GHETLRDGDRHSLRQDGARCELQIRGLVAEDAGEYLCMCGKERTS 3704
Query: 1158 PRLS-RPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASST 1216
L+ R + + RN E+ G A + C + P + H L
Sbjct: 3705 AMLTVRAMPSKFIEGLRN------EEATEGDTATLWCELSKAAPVEWRKGH--ETLRDGD 3756
Query: 1217 AASV---PNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEA---A 1270
S+ + L++RG D G YSC GQ TS L + + +
Sbjct: 3757 RHSLRQDGSRCELQIRGLAVVDAGEYSCVC----GQERTSATLTVRALPARFIEDVKNQE 3812
Query: 1271 VPEGAPITVTC----ADPAAHAPTLYTWYHNGRW--LQEGPAASLSFLVATRAHAGAYSC 1324
EGA + C A P T R+ Q+G L + A G YSC
Sbjct: 3813 AREGATAVLQCELSKAAPVEWRKGSETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSC 3872
Query: 1325 QAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHD 1382
R +A + APQ + +A S A +QC + SEP A
Sbjct: 3873 VC------GQERTSATLTVRAPQPVFREPLQSLQAEEGSTATLQCEL-SEPTA------- 3918
Query: 1383 GKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQ 1441
V+ + G+ A+G ++ L +QD+ D Y CT GS +T L
Sbjct: 3919 -TVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTC----GSQATSATLT 3973
Query: 1442 VEGARVVAEPGL---DVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP------ 1492
V A V L +V EG +L C L V W L P
Sbjct: 3974 VTAAPVRFLRELQHQEVDEGGTAHLCCELSRAGASVE-------WRKGSLQLFPCAKYQM 4026
Query: 1493 -----VPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGG 1547
L V + AG Y C TG S + + PK T + +E E G
Sbjct: 4027 VQDGAAAELLVRGVEQEDAGDYTC----DTGHTQSMASLSVRVPRPKFKTRLQSLEQETG 4082
Query: 1548 LRGILDCRV-DSEPLA-------SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVD 1599
L C++ D+E A + LH G + S QGA E IH
Sbjct: 4083 DIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRS--QGATRELLIH----------- 4129
Query: 1600 IEALRPSDQGEYICSASNVLGSAS 1623
L D GEY C +AS
Sbjct: 4130 --QLEAKDTGEYACVTGGQKTAAS 4151
Score = 108 bits (269), Expect = 6e-23
Identities = 242/1165 (20%), Positives = 397/1165 (34%), Gaps = 237/1165 (20%)
Query: 255 GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYT 304
G L+C+V A + + W KDG +L + + V L LPQA +DAG Y+
Sbjct: 1089 GASAMLSCEVAQ---AQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYS 1145
Query: 305 CQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTV---------TLVCNTPNEAPSD 355
C+A +S H+ + E P G + Q+V T + A
Sbjct: 1146 CEAG-------GQRVSFHLHITE----PKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQ 1194
Query: 356 LRYSWYKNHVLLEDAHSHTLRLHLATR---------ADTGFYFCEVQNVHGSER---SGP 403
+WYK+ L + + + TR AD G Y CE S + + P
Sbjct: 1195 TEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEP 1254
Query: 404 VSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSP 463
+V ++ + T+AG L C V G + +S+
Sbjct: 1255 KAVFAKE----QLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSS-------- 1302
Query: 464 RFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN--------AARLLI 515
+ + +L ++ + D+GEY C A L FH + A L
Sbjct: 1303 KVRIEAAGCMRQLVVQQAGQADAGEYTCEA------GGQRLSFHLDVSEPKAVFAKEQLA 1356
Query: 516 SPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHE---------GPGSSLLLPAAS 566
+ G TLSC + T +WY +G L G L++ A
Sbjct: 1357 HRKVQAEAGAIATLSCEVAQAQT---EVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQAC 1413
Query: 567 STDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRV 626
D G Y C A G S A V++ QP A AG L C V
Sbjct: 1414 QADTGEYSCEA-GGQRLSFSLDVAEPKVVFAKEQPVHR------EVQAQAGASTTLSCEV 1466
Query: 627 DSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGL 686
A+ +++ S S GC+ R+ V +A + G
Sbjct: 1467 ---AQAQTEVMWYKDGKKLSFSSKVRMEAV-GCTRRLVVQQAGQAV-----------AGE 1511
Query: 687 YLCEASNA-----LGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPAN 741
Y CEA + L A A F A + + GT A L+C E A +
Sbjct: 1512 YSCEAGSQRLSFHLHVAEPKAVF---AKEQPASREVQAEAGTSATLSC----EVAQAQTE 1564
Query: 742 FSWFRNGV---------LWAQGPLETVTLLPVARTDAALYACRILTEAGAQ-------LS 785
+W+++G + A G + + + DA Y+C+ AG Q ++
Sbjct: 1565 VTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCK----AGDQRLSFHLHVA 1620
Query: 786 TPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVP 845
P ++ P ++ A G A C V + G+ L ++S
Sbjct: 1621 EPKVVFAKEQPAHREVQA----EAGASATLSCEVAQAQTEVTWYKDGKKLSSSS------ 1670
Query: 846 SHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSP- 904
+ + +A + +L V++ G D+G Y CEA G S V Q+S P
Sbjct: 1671 ---KVRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQRLSFRLHVAELEPQISERPC 1723
Query: 905 -----ELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQES---------TSATLRFAAI 950
++E + ++L+ + T P + W +DG ++ S + TL
Sbjct: 1724 RREPLVVKEHEDIILTATLAT--PSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGA 1781
Query: 951 TLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSD 1010
+ + Y C+ A G V L++ G LG +
Sbjct: 1782 QVLDSAIYSCRVGAEGQ---------DFPVQVEEVAAKFCRLLEPVCGELGGTVTLACEL 1832
Query: 1011 PPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLR-LEIHGAMLEDEGVYICEA 1069
PA A + G + + VA +R L + G ED G Y+CE+
Sbjct: 1833 SPA----------CAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCES 1882
Query: 1070 SNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDG---- 1125
+ A + + EG C+V P+ + W++DG
Sbjct: 1883 RDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVV---SPSDVAVVWFRDGALLQ 1939
Query: 1126 -------QQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLT 1178
Q +HS+ + ++ + DA A S L V AP +
Sbjct: 1940 PSEKFAISQSGASHSLTISDLVLEDAGQITV------EAEGASSSAALRVREAPVLFKKK 1993
Query: 1179 YLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPR---- 1234
++ + ++ L +RP +L R ++TA + + + G + R
Sbjct: 1994 LEPQTVEERSSVTLEVELTRPWPEL------RWTRNATALAPGKNVEIHAEGARHRLVLH 2047
Query: 1235 -----DEGFYSCSARSPLGQANTSLELR----LEGVRVILAPEAAVPEGAPITVTCADPA 1285
D GF+ C QA ++E+R + G++ + A E T T
Sbjct: 2048 NVGFADRGFFGCETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQG-------TATMEVQL 2100
Query: 1286 AHAPTLYTWYHNGRWLQEGPAASLS 1310
+HA +W +G Q+GP L+
Sbjct: 2101 SHADVDGSWTRDGLRFQQGPTCHLA 2125
Score = 107 bits (268), Expect = 8e-23
Identities = 282/1306 (21%), Positives = 449/1306 (34%), Gaps = 223/1306 (17%)
Query: 441 ATLVLSHGGHILASTSGDSDHSP-----RFSGTSGPNSLRLEIRDLEETDSGEYKCSATN 495
ATL G+ S + D P RF + RL I DL DSG+Y C A N
Sbjct: 27 ATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARN 86
Query: 496 SLGNATSTLDFHANAAR---------LLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWY 546
++G A + + +A LL + V EG T CR G SP P SW
Sbjct: 87 AIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRP--AVSWS 144
Query: 547 LNGALLHE-----------GPGSSLLLPAASSTDAGSYHCRAR--------------DGH 581
+G L E G S+L + AA D G+Y RA D
Sbjct: 145 KDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSD 204
Query: 582 SASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDR 641
+A S P T + + A A G C V ARL
Sbjct: 205 AADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGE 264
Query: 642 VVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTS 701
++ G G + N + ++I + GLY C ASN +G +S
Sbjct: 265 PKPETVWKKDGQLVTEGRRHVVYEDAQENFV-LKILFCKQSDRGLYTCTASNLVGQTYSS 323
Query: 702 ATFNGQATVLAI---APSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV-LWA----- 752
+ + ++E A C V + + + +WF+ LWA
Sbjct: 324 VLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPSTEA----AWFKEETRLWASAKYG 379
Query: 753 ---QGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQ 809
+G +T+ V+ D A+Y C T G++ + + P+ +A +
Sbjct: 380 IEEEGTERRLTVRNVSADDDAVYICE--TPEGSRTVAELAVQGNLLRKLPRKTA---VRV 434
Query: 810 GHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869
G A+F C + P+ + + +V + GR AE L + + L
Sbjct: 435 GDTAMF-CVELAVPVGPVHWLRNQE--------EVVAGGRVAISAEGTRHTLTISQCCLE 485
Query: 870 DSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGV------- 922
D G + + G TS F V P LQ V+ ++ + V
Sbjct: 486 DVG----QVAFMAGDCQTSTQF-----CVSAPRKPPLQPPVDPVVKARMESSVILSWSPP 536
Query: 923 PEGT----------------SYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPG 966
P G +Y W R + AT + + G + + A
Sbjct: 537 PHGERPVTIDGYLVEKKKLGTYTWIRCH---EAEWVATPELTVADVAEEGNFQFRVSALN 593
Query: 967 SATTS--LAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVD-SDPPAQLRLLHGDRL 1023
S S L P ++H+ AP+ T L G + VD + A L G L
Sbjct: 594 SFGQSPYLEFPGTVHL--APKLAVRTPLKAVQAVEGGEVTFSVDLTVASAGEWFLDGQAL 651
Query: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFD 1083
AS++ E R + + +HGA L+ ++ + + A
Sbjct: 652 KASSVY-----EIHCDRTRHTLTIREVPASLHGAQLK----FVANGIESSIRMEVRA--- 699
Query: 1084 AQAVNVQVWPGATVRE--GQLVNLTCLVWTTHPAQLTYTWYQDG-----------QQRLD 1130
A + P A RE +L L+ TW +DG Q
Sbjct: 700 APGLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAG 759
Query: 1131 AHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVL--YAPRNLRLTYLLESHGGQL 1188
+ + +V DA Y C R R++ +++ L + +++ + + GG
Sbjct: 760 RRVLLVRDVARDDAGLYEC----VSRGGRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPA 815
Query: 1189 ALVLCTVDSRPPAQ-----LALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSA 1243
T ++ + L H+G V RL +DEG YSC
Sbjct: 816 QFECETSEAHVHVHWYKDGMELGHSGERFLQE---DVGTRHRLVAATVTRQDEGTYSCR- 871
Query: 1244 RSPLGQANTSLELRLEGVRVILAPE------AAVPEGAPITVTCADPAAHAPTLYTWYHN 1297
+G+ + LR+ +V+ A E GA T++C A A T TWY +
Sbjct: 872 ---VGEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSC--EVAQAQTEVTWYKD 926
Query: 1298 GRWLQEGPAASLSFLVATR---------AHAGAYSCQAQDAQGTRSSRPAALQVLYAPQD 1348
G+ L + TR A AG YSC+A + + +V++A +D
Sbjct: 927 GKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFA-KD 985
Query: 1349 AVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNA 1408
V S + A + A + C V ++ E+ DGK L++S VH A G R
Sbjct: 986 QVAHSEVQAEAGASATLSCEV-AQAQTEVMWYKDGKKLSSSLKVHVEAKG-----CRRRL 1039
Query: 1409 LRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVV------AEPGLDVPEGAALN 1462
+ Q AGD Y C A+ S RL + +++ + GA+
Sbjct: 1040 VVQQAGKTDAGD--YSCEARGQRVSF----RLHITEPKMMFAKEQSVHNEVQAEAGASAM 1093
Query: 1463 LSCRLLGGPGPVGNSTFAWFWNDRRLHAEP---------VPTLAFTHVARAQAGMYHCLA 1513
LSC + V W+ + ++L + L +A AG Y C A
Sbjct: 1094 LSCEVAQAQTEV-----TWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEA 1148
Query: 1514 ELPTGAAASAPVMLRVLYP----PKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLG 1569
L + P K ++ V+ E G +L C V ++P +T +
Sbjct: 1149 -----GGQRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEV-AQPQTEVTWYKD 1202
Query: 1570 SRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSA 1615
+ ++SS + + R+ ++ + +D GEY C A
Sbjct: 1203 GKKLSSSS--------KVRMEVKGCTRRLVVQQVGKADAGEYSCEA 1240
Score = 106 bits (264), Expect = 2e-22
Identities = 312/1484 (21%), Positives = 520/1484 (35%), Gaps = 255/1484 (17%)
Query: 256 ELVTLTCQVNSSYPAVSSIKWLKDGVRL--QTKTGV--------LHLPQAAWSDAGVYTC 305
E T C+V P+ + W K+ RL K G+ L + + D VY C
Sbjct: 348 ESATFLCEVPQ--PSTEAA-WFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYIC 404
Query: 306 QAENGVGSLVSPPISLHI-----------------FMAEVQVSPAGPI--LENQTVTLVC 346
+ G ++ + ++ F E+ V P GP+ L NQ +
Sbjct: 405 ETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAV-PVGPVHWLRNQEEVVAG 463
Query: 347 NTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSV 406
+ R++ + LED +A T FC + R P+
Sbjct: 464 GRVAISAEGTRHTLTISQCCLEDVGQVAF---MAGDCQTSTQFCV-----SAPRKPPLQ- 514
Query: 407 VVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFS 466
PP+ PV+ A +E+ L S P ++ G+++ + R
Sbjct: 515 ----PPVDPVVKARMESSVIL------SWSPPPHGERPVTIDGYLVEKKKLGTYTWIRCH 564
Query: 467 GTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHAN---AARLLISP---AAE 520
+ L + D+ E + +++ SA NS G + L+F A +L + A +
Sbjct: 565 EAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPY-LEFPGTVHLAPKLAVRTPLKAVQ 623
Query: 521 VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDG 580
VEG VT S + T + W+L+G L ++ HC R
Sbjct: 624 AVEGGEVTFS----VDLTVASAGEWFLDGQAL-------------KASSVYEIHCD-RTR 665
Query: 581 HSASGPSSPAVL---TVLYPPRQPTFTTRLDLDAAG--------AGAGRRGLLLCRVDSD 629
H+ + PA L + + + R+++ AA A A R +L R+ +
Sbjct: 666 HTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAARE--VLARLHEE 723
Query: 630 PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLC 689
+L D+ A + G + G P+ +V + + + + ++ GLY C
Sbjct: 724 AQLLAEL--SDQAAAVTWLKDGRTLSPG---PKYEVQASAGRRVLLVRDVARDDAGLYEC 778
Query: 690 EASNALGNASTSATFNGQATVLAIAPSHTLQE---GTEANLTCNVSREAAGSPANFSWFR 746
+ G + + G A L + + + G A C S + + W++
Sbjct: 779 VSRG--GRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPAQFECETSE----AHVHVHWYK 832
Query: 747 NGVLWAQ----------GPLETVTLLPVARTDAALYACRILTEA---GAQLSTPVLLSVL 793
+G+ G + V R D Y+CR+ ++ ++S P ++
Sbjct: 833 DGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKVVFAK 892
Query: 794 YPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAK 853
R KL A G A C V + G+ L ++S + +
Sbjct: 893 EQLARRKLQA----EAGASATLSCEVAQAQTEVTWYKDGKKLSSSS---------KVCME 939
Query: 854 AEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV-----QVSPSP-ELQ 907
A + +L V++ G D+G Y CEA G S V+ V QV+ S + +
Sbjct: 940 ATGCTRRLVVQQAGQADAGEYSCEA----GGQRLSFHLDVKEPKVVFAKDQVAHSEVQAE 995
Query: 908 EGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSA---------TLRFAAITLTQAGAY 958
G + LSC+V T WY+DG+ L S L T AG Y
Sbjct: 996 AGASATLSCEV---AQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDY 1052
Query: 959 HCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLL 1018
C+A+ S I+ + ++ + G +L C V
Sbjct: 1053 SCEAR---GQRVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQTEVTWYK 1109
Query: 1019 HGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA-----SNTL 1073
G +L SS ++ + V T RL + A D G Y CEA S L
Sbjct: 1110 DGKKL------------SSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSFHL 1157
Query: 1074 GQASASADF-DAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH 1132
F Q+V+ +V A G L+C V Q TWY+DG++ +
Sbjct: 1158 HITEPKGVFAKEQSVHNEVQAEA----GTTAMLSCEV---AQPQTEVTWYKDGKKLSSSS 1210
Query: 1133 SIPL-----------PNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLL 1181
+ + V DA Y C G G+ IT + + +
Sbjct: 1211 KVRMEVKGCTRRLVVQQVGKADAGEYSCEAG--GQRVSFQLHITEPKAVFAKEQLVHNEV 1268
Query: 1182 ESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNT---LRLELRGPQPRDEGF 1238
+ G A + C V ++ ++ G+ L+SS+ + +L ++ D G
Sbjct: 1269 RTEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGE 1327
Query: 1239 YSCSARSPLGQANTSLELRLEGVRVILAPE------AAVPEGAPITVTCADPAAHAPTLY 1292
Y+C A G S L + + + A E GA T++C A A T
Sbjct: 1328 YTCEA----GGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSC--EVAQAQTEV 1381
Query: 1293 TWYHNGRWLQEGPAASLSFLVATR---------AHAGAYSCQAQDAQGTRSSRPAALQVL 1343
TWY +G+ L + + TR A G YSC+A + + S A +V+
Sbjct: 1382 TWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVV 1441
Query: 1344 YAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403
+A + V + ++A + + C V ++ E+ DGK L+ SS V A G
Sbjct: 1442 FAKEQPVHREVQ-AQAGASTTLSCEV-AQAQTEVMWYKDGKKLSFSSKVRMEAVG----- 1494
Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNL 1463
R + Q AG+ + +Q L + V A + G + L
Sbjct: 1495 CTRRLVVQQAGQAVAGEYSCEAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATL 1554
Query: 1464 SCRLLGGPGPVGNSTFAWFWNDRRLHAEP---------VPTLAFTHVARAQAGMYHCLA- 1513
SC + V W+ + ++L + L +A AG Y C A
Sbjct: 1555 SCEVAQAQTEV-----TWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAG 1609
Query: 1514 --ELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSR 1571
L + P +V++ + P V+ E G L C V G +
Sbjct: 1610 DQRLSFHLHVAEP---KVVFAKEQPAHRE-VQAEAGASATLSCEVAQAQTEVTWYKDGKK 1665
Query: 1572 LVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSA 1615
L +SS+ + V A R+ ++ +D GEY C A
Sbjct: 1666 LSSSSK---------VRVEAVGCTRRLVVQQAGQADAGEYSCEA 1700
Score = 104 bits (260), Expect = 6e-22
Identities = 291/1322 (22%), Positives = 444/1322 (33%), Gaps = 219/1322 (16%)
Query: 94 EHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEG 153
E + L+++ +D+G Y E S+ V+ TEE L
Sbjct: 2877 EGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEE------------LTN 2924
Query: 154 TEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFN--------SQKFEPTGVGHLETLHMA 205
+V+ + + C E PA +VT+ S K +P+ G L ++
Sbjct: 2925 LQVEEKGTAVFTCKTEH---------PAATVTWRKGLLELRASGKHQPSQEGLTLRLTIS 2975
Query: 206 MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVN 265
+ C + A RAQ + + V I+ ++ G T C+++
Sbjct: 2976 ALEKADSDTYTCDIGQAQSRAQLLVQ------GRRVHIIEDLEDVDVQEGSSATFRCRIS 3029
Query: 266 SSYPAVSSIKWLKDGVRLQTKT-----------GVLHLPQAAWSDAG-VYTCQAENGVGS 313
+ + W D L VL L Q A D+G +Y + +
Sbjct: 3030 PAN--YEPVHWFLDKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEAGDQRASA 3087
Query: 314 LVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLE----- 368
+ +F E+ + I E + +TLVC T + D+ W K+ L
Sbjct: 3088 ALRVTEKPSVFSRELTDAT---ITEGEDLTLVCET---STCDIPVCWTKDGKTLRGSARC 3141
Query: 369 ----DAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQ 424
+ H L + AT D+G Y CE G S + V P LE
Sbjct: 3142 QLSHEGHRAQLLITGATLQDSGRYKCEA----GGACSSSIVRVHARPVRFQEALKDLEVL 3197
Query: 425 AGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEET 484
G L C V+S A + +G ++L GD +S R G L L +R+L
Sbjct: 3198 EGGAATLRC-VLSSVAAPVKWCYGNNVLRP--GDK-YSLRQEGAM----LELVVRNLRPQ 3249
Query: 485 DSGEYKCSATNSLGNATSTLDFHANAARLLIS-PAAEVVEGQAVTLSCR-SGLSPTPDAR 542
DSG Y CS + +AT T+ A A+ + E EG TL C S +P +
Sbjct: 3250 DSGRYSCSFGDQTTSATLTVT--ALPAQFIGKLRNKEATEGATATLRCELSKAAPVEWRK 3307
Query: 543 FSWYLNG----ALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
S L L +G L + + DA Y C + ++ A LT+ P
Sbjct: 3308 GSETLRDGDRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTS------ASLTI--RP 3359
Query: 599 RQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGG 658
F RL + GA L C + P R SL G
Sbjct: 3360 MPAHFIGRLRHQESIEGA--TATLRCELSKAAPVEW------RKGRESLRDG-------- 3403
Query: 659 CSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAP--- 715
R + + + ++I + + G Y C G TSAT +A
Sbjct: 3404 --DRHSLRQDGAVCELQICGLAVADAGEYSC----VCGEERTSATLTVKALPAKFTEGLR 3457
Query: 716 SHTLQEGTEANLTCNVSR----EAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAAL 771
+ EG A L C +S+ E P N +L +G + + +A DA
Sbjct: 3458 NEEAVEGATAMLWCELSKVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGE 3517
Query: 772 YACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFH 831
Y C E + T L + D A +G A+ C ++S A +
Sbjct: 3518 YLCVCGQERTSATLTIRALPARFIEDVKNQEA----REGATAVLQCELNS--AAPVEWRK 3571
Query: 832 GEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFF 891
G L R+ + + +L++R L + D+G Y C V G TS
Sbjct: 3572 GSETLRDG--------DRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAML 3619
Query: 892 QVRGAWVQVSP---SPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL---------QE 939
VR ++ + + E EG VL C++ P W++ + L Q+
Sbjct: 3620 TVRALPIKFTEGLRNEEATEGATAVLRCELSKMAP----VEWWKGHETLRDGDRHSLRQD 3675
Query: 940 STSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGR 999
L+ + AG Y C G TS + S + + + G
Sbjct: 3676 GARCELQIRGLVAEDAGEYLCMC---GKERTSAMLTVRAMPS---KFIEGLRNEEATEGD 3729
Query: 1000 LGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAML 1059
L C + P + R H TL+ R + + L+I G +
Sbjct: 3730 TATLWCELSKAAPVEWRKGH------ETLR-------DGDRHSLRQDGSRCELQIRGLAV 3776
Query: 1060 EDEGVYIC-----EASNTLGQASASADFDAQAVNVQVWPGAT-VREGQLVNLTCLVWTTH 1113
D G Y C S TL + A F N + GAT V + +L + W
Sbjct: 3777 VDAGEYSCVCGQERTSATLTVRALPARFIEDVKNQEAREGATAVLQCELSKAAPVEWRKG 3836
Query: 1114 PAQL----TYTWYQDGQQ-RLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV 1168
L Y+ QDG + L H + +V D Y C G + L+ V
Sbjct: 3837 SETLRGGDRYSLRQDGTRCELQIHGL-----SVADTGEYSCVCGQERTSATLTVRAPQPV 3891
Query: 1169 LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPN----TL 1224
P L++ G A + C + S P A + S G L + P T
Sbjct: 3892 FREP-----LQSLQAEEGSTATLQCEL-SEPTATVVWSKGG-LQLQANGRREPRLQGCTA 3944
Query: 1225 RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPE---AAVPEGAPITVTC 1281
L L+ Q D G Y+C+ G TS L + V E V EG + C
Sbjct: 3945 ELVLQDLQREDTGEYTCTC----GSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLCC 4000
Query: 1282 ADPAAHAPTLYTWYHNG---------RWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGT 1332
+ A W + +Q+G AA L + AG Y+C Q
Sbjct: 4001 --ELSRAGASVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSM 4058
Query: 1333 RS 1334
S
Sbjct: 4059 AS 4060
Score = 103 bits (257), Expect = 1e-21
Identities = 274/1256 (21%), Positives = 423/1256 (33%), Gaps = 235/1256 (18%)
Query: 274 IKWLKDGVRL--------QTKTGVLHLPQAAW---SDAGVYTCQA-ENGVGSLVSPPISL 321
+ W KDG+ L Q G H AA D G Y+C+ E+ V +
Sbjct: 828 VHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPK 887
Query: 322 HIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH---------S 372
+F E + TL C A + +WYK+ L + +
Sbjct: 888 VVFAKEQLARRKLQAEAGASATLSCEV---AQAQTEVTWYKDGKKLSSSSKVCMEATGCT 944
Query: 373 HTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLT----PVLTAFLETQAGLV 428
L + A +AD G Y CE G +R + V P + V + ++ +AG
Sbjct: 945 RRLVVQQAGQADAGEYSCEA----GGQRLS-FHLDVKEPKVVFAKDQVAHSEVQAEAGAS 999
Query: 429 GILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGE 488
L C V + G + +S + + RL ++ +TD+G+
Sbjct: 1000 ATLSCEVAQAQTEVMWYKDGKKLSSSLKVHVE--------AKGCRRRLVVQQAGKTDAGD 1051
Query: 489 YKCSATNSLGNATSTLDFHANAARLLISPAAEVVE------GQAVTLSCRSGLSPTPDAR 542
Y C A + H +++ + V G + LSC + T
Sbjct: 1052 YSCEARGQ----RVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQT---E 1104
Query: 543 FSWYLNGALLH---------EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLT 593
+WY +G L +G L+LP A DAG Y C A G +
Sbjct: 1105 VTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEA-------GGQRVSFHL 1157
Query: 594 VLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGC 653
+ P+ + + A AG +L C V P +KD +S S
Sbjct: 1158 HITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQ--PQTEVTWYKDGKKLSS--SSKVR 1213
Query: 654 STCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAI 713
GC+ R+ V + + G Y CEA S V A
Sbjct: 1214 MEVKGCTRRLVVQQVGKA-----------DAGEYSCEAGGQ--RVSFQLHITEPKAVFAK 1260
Query: 714 APSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLETVTLLPV 764
+ TEA + +S E A + +W+++G + A G + + +
Sbjct: 1261 EQLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQA 1320
Query: 765 ARTDAALYACRILTEAGAQ-------LSTPVLLSVLYPPDRPKLSALLDMGQGHMALFIC 817
+ DA Y C EAG Q +S P + K+ A G +A C
Sbjct: 1321 GQADAGEYTC----EAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQA----EAGAIATLSC 1372
Query: 818 TVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCE 877
V + G+ L ++S + + +A + +L V++ D+G Y CE
Sbjct: 1373 EVAQAQTEVTWYKDGKKLSSSS---------KVRMEAVGCTRRLVVQQACQADTGEYSCE 1423
Query: 878 ATNVLGSSNTSLFFQVRGAWV------QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWY 931
A G S V V V + Q G + LSC+V T WY
Sbjct: 1424 A----GGQRLSFSLDVAEPKVVFAKEQPVHREVQAQAGASTTLSCEV---AQAQTEVMWY 1476
Query: 932 RDGQPLQESTSATLRFAAITLTQ-----------AGAYHCQAQAPGSATTSLAAPISLHV 980
+DG+ L S S+ +R A+ T+ AG Y C+A GS S ++
Sbjct: 1477 KDGKKL--SFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCEA---GSQRLSFHLHVAEPK 1531
Query: 981 SYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPR 1040
+ + + + G L C V G +L SS +
Sbjct: 1532 AVFAKEQPASREVQAEAGTSATLSCEVAQAQTEVTWYKDGKKL------------SSSSK 1579
Query: 1041 LHVAVAPNTLRLEIHGAMLEDEGVYICEASNT-----LGQASASADFDAQAV---NVQVW 1092
+ + T RL + A D G Y C+A + L A F + VQ
Sbjct: 1580 VRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAE 1639
Query: 1093 PGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVR---------- 1142
GA+ L+C V AQ TWY+DG++ + + + V
Sbjct: 1640 AGASA------TLSCEV---AQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQ 1690
Query: 1143 -DATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALV--LCTVDSRP 1199
DA Y C G + RL L+ + R R L+ + L L T +
Sbjct: 1691 ADAGEYSCEAGGQRLSFRL-HVAELEPQISERPCRREPLVVKEHEDIILTATLATPSAAT 1749
Query: 1200 PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE 1259
L R AS +T L + G Q D YSC +G +++E
Sbjct: 1750 VTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCR----VGAEGQDFPVQVE 1805
Query: 1260 GVRV----ILAPEAAVPEGAPITVTCADPAAHAPTLY----TWYHNGRWLQ---EGPAAS 1308
V +L P G +T+ C A A ++ T G+ Q EGP S
Sbjct: 1806 EVAAKFCRLLEPVCG-ELGGTVTLACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRS 1864
Query: 1309 LSFLVATRAHAGAYSCQAQD----AQGTRS------------------SRPAALQVLYAP 1346
L+ L AG Y C+++D AQ T S A Q + +P
Sbjct: 1865 LTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVVSP 1924
Query: 1347 QDAVLSSFRDSR----ARSMAVIQCTVD-SEPPAELALSHDGKVLATSSGVHSLAS 1397
D + FRD + A+ Q S ++L L G++ + G S A+
Sbjct: 1925 SDVAVVWFRDGALLQPSEKFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAA 1980
Score = 102 bits (255), Expect = 2e-21
Identities = 283/1294 (21%), Positives = 450/1294 (34%), Gaps = 235/1294 (18%)
Query: 59 WYYDYSGQRQVVSHSADPKLVEARFRG--------RTEFMGNPEHRVCNLLLKDLQPEDS 110
W G+R V + D LVE + G E++ PE L + D+ E
Sbjct: 533 WSPPPHGERPV---TIDGYLVEKKKLGTYTWIRCHEAEWVATPE-----LTVADVAEEG- 583
Query: 111 GSYNFRFEISEVNRWS-----DVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYV 165
NF+F +S +N + + GT V + + V T V+ +EG EV F+
Sbjct: 584 ---NFQFRVSALNSFGQSPYLEFPGT-VHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVA 639
Query: 166 CLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLE---TLHMAMSWQDHGRILRCQLSVA 222
E W + Q + + V + T H + + QL
Sbjct: 640 SAGE-----W---------FLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFV 685
Query: 223 NHRAQSEIHLQVKYAPKGVKILLSPSG--RNILPG--ELVTLTCQVNSSYPAVSSIKWLK 278
+ +S I ++V+ AP G+ P+ R +L E L +++ AV+ WLK
Sbjct: 686 ANGIESSIRMEVRAAP-GLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVT---WLK 741
Query: 279 DGVRL--------QTKTG--VLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEV 328
DG L Q G VL + A DAG+Y C + G + L F+ +
Sbjct: 742 DGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKD 801
Query: 329 QVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHV---------LLEDAHS-HTLRLH 378
+ C T + + + WYK+ + L ED + H L
Sbjct: 802 MAGSCVDAVAGGPAQFECET---SEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAA 858
Query: 379 LATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLT----PVLTAFLETQAGLVGILHCS 434
TR D G Y C V E S + V+ P + + L+ +AG L C
Sbjct: 859 TVTRQDEGTYSCRV-----GEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSCE 913
Query: 435 VVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSAT 494
V G + +S+ + + + RL ++ + D+GEY C A
Sbjct: 914 VAQAQTEVTWYKDGKKLSSSS--------KVCMEATGCTRRLVVQQAGQADAGEYSCEAG 965
Query: 495 NSLGNATSTLDFHANAARLLISPAAEVVE--------GQAVTLSCRSGLSPTPDARFSWY 546
L FH + + A + V G + TLSC + T WY
Sbjct: 966 GQ------RLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSCEVAQAQT---EVMWY 1016
Query: 547 LNGALLH---------EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYP 597
+G L +G L++ A TDAG Y C AR G S +++
Sbjct: 1017 KDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEAR-GQRVSFRLHITEPKMMFA 1075
Query: 598 PRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLL-HKDRVVATSLPSGGGCSTC 656
Q + A AG +L C V A+ ++ +KD +S G
Sbjct: 1076 KEQSVH------NEVQAEAGASAMLSCEV---AQAQTEVTWYKDGKKLSSSSKVG--MEV 1124
Query: 657 GGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPS 716
GC+ R+ + +A + G Y CEA S V A S
Sbjct: 1125 KGCTRRLVLPQAGK-----------ADAGEYSCEAGGQ--RVSFHLHITEPKGVFAKEQS 1171
Query: 717 HTLQEGTEANLTCNVSREAAGSPANFSWFRNGV---------LWAQGPLETVTLLPVART 767
+ EA T +S E A +W+++G + +G + + V +
Sbjct: 1172 VHNEVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKA 1231
Query: 768 DAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLD----MGQGHMALFICTVDSRP 823
DA Y+C EAG Q L + P L+ G A C V
Sbjct: 1232 DAGEYSC----EAGGQ-RVSFQLHITEPKAVFAKEQLVHNEVRTEAGASATLSCEVAQAQ 1286
Query: 824 LALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLG 883
+ G+ L ++S + + +A +L V++ G D+G Y CEA G
Sbjct: 1287 TEVTWYKDGKKLSSSS---------KVRIEAAGCMRQLVVQQAGQADAGEYTCEA----G 1333
Query: 884 SSNTSLFFQVRGAWVQVSPSP------ELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL 937
S V + + + G LSC+V E T WY+DG+ L
Sbjct: 1334 GQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQTEVT---WYKDGKKL 1390
Query: 938 QESTSATLRFAAITLTQ-----------AGAYHCQAQAPG-SATTSLAAPISLHVSYAPR 985
S+S+ +R A+ T+ G Y C+A S + +A P + P
Sbjct: 1391 --SSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVFAKEQPV 1448
Query: 986 HVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAV 1045
H + G L C V + G +L S ++ +
Sbjct: 1449 H----REVQAQAGASTTLSCEVAQAQTEVMWYKDGKKL------------SFSSKVRMEA 1492
Query: 1046 APNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNL 1105
T RL + A G Y CEA + + +AV + P + + +
Sbjct: 1493 VGCTRRLVVQQAGQAVAGEYSCEAGSQRLSFHLHV-AEPKAVFAKEQPASREVQAEAGTS 1551
Query: 1106 TCLVWTTHPAQLTYTWYQDGQQ-------RLDA----HSIPLPNVTVRDATSYRCGVGPP 1154
L AQ TWY+DG++ R++A + + DA Y C G
Sbjct: 1552 ATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQ 1611
Query: 1155 GRAPRL--SRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLL 1212
+ L + P + P + +++ G A + C V ++ ++ G+ L
Sbjct: 1612 RLSFHLHVAEPKVVFAKEQPAHRE----VQAEAGASATLSCEV-AQAQTEVTWYKDGKKL 1666
Query: 1213 ASST---AASVPNTLRLELRGPQPRDEGFYSCSA 1243
+SS+ +V T RL ++ D G YSC A
Sbjct: 1667 SSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA 1700
Score = 94.7 bits (234), Expect = 7e-19
Identities = 329/1543 (21%), Positives = 511/1543 (33%), Gaps = 276/1543 (17%)
Query: 229 EIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSS-YPAVSSIKWLKDGVRLQTKT 287
++ + A + LL P+ + G T C+V S PAVS W KDG RL
Sbjct: 98 QVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVS---WSKDGRRLGEPD 154
Query: 288 G------------VLHLPQAAWSDAGVYTCQAENGVGSLVS----------------PPI 319
G L + A D G Y +AEN +G+ + P
Sbjct: 155 GPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGT 214
Query: 320 SLHIFMAEVQV---------SPAGP---------ILENQTVTLVCNTPNEAPSDLRYSWY 361
S +A +Q +PA P + E + L C E + W
Sbjct: 215 STAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPET--VWK 272
Query: 362 KN---------HVLLEDAHSH-TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHP 411
K+ HV+ EDA + L++ ++D G Y C N+ G S + VV
Sbjct: 273 KDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVV--RE 330
Query: 412 PLTPVLTAF--LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTS 469
P P LE + C V + AS + GT
Sbjct: 331 PAVPFKKRLQDLEVREKESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEE----GTE 386
Query: 470 GPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTL 529
RL +R++ D Y C + L N R L P V +
Sbjct: 387 R----RLTVRNVSADDDAVYICETPEG-SRTVAELAVQGNLLRKL--PRKTAVRVGDTAM 439
Query: 530 SCRSGLSPTPDARFSWYLNG---------ALLHEGPGSSLLLPAASSTDAGSY-----HC 575
C P W N A+ EG +L + D G C
Sbjct: 440 FCVELAVPVGPVH--WLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDC 497
Query: 576 RARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635
+ S P P L PP P R++ + S PP +
Sbjct: 498 QTSTQFCVSAPRKPP----LQPPVDPVVKARMESSVILSW------------SPPPHGER 541
Query: 636 LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695
+ D + G T C V P L ++ EEG + S AL
Sbjct: 542 PVTIDGYLVEKKKLG--TYTWIRCHEAEWVA-TPELTVADV-----AEEGNFQFRVS-AL 592
Query: 696 GNASTSATFNGQATV-----LAI-APSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRN 747
+ S TV LA+ P +Q EG E + +++ +AG WF +
Sbjct: 593 NSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVASAGE-----WFLD 647
Query: 748 G-VLWAQGPLE-----TVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPP----D 797
G L A E T L + A+L+ ++ A + + + + V P +
Sbjct: 648 GQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANG-IESSIRMEVRAAPGLTAN 706
Query: 798 RPKLSALLD-MGQGHM-ALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAE 855
+P +A + + + H A + + + A+ L G L S GP +++ +A
Sbjct: 707 KPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTL---SPGP------KYEVQAS 757
Query: 856 ANSLKLEVRELGLGDSGSYRCEA--------TNVLGSSNTSLFFQVRGAWVQ-VSPSPEL 906
A L VR++ D+G Y C + +V G + L + G+ V V+ P
Sbjct: 758 AGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLAR-FLHKDMAGSCVDAVAGGPAQ 816
Query: 907 QEGQAVVLSCQVHTGVPEGTSYRWYRDGQP--------LQESTSATLRFAAITLTQ--AG 956
E + VH WY+DG LQE R A T+T+ G
Sbjct: 817 FECETSEAHVHVH----------WYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEG 866
Query: 957 AYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLR 1016
Y C+ G + +S + + G L C V
Sbjct: 867 TYSCRV---GEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVTW 923
Query: 1017 LLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQA 1076
G +L SS ++ + T RL + A D G Y CEA G
Sbjct: 924 YKDGKKL------------SSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEA----GGQ 967
Query: 1077 SASADFDAQAVNV-----QVWPGATVRE-GQLVNLTCLVWTTHPAQLTYTWYQDGQQ--- 1127
S D + V QV E G L+C V AQ WY+DG++
Sbjct: 968 RLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSCEV---AQAQTEVMWYKDGKKLSS 1024
Query: 1128 RLDAH--------SIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY 1179
L H + + DA Y C G+ IT + + +
Sbjct: 1025 SLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEA--RGQRVSFRLHITEPKMMFAKEQSVHN 1082
Query: 1180 LLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVP---NTLRLELRGPQPRDE 1236
+++ G A++ C V ++ ++ G+ L+SS+ + T RL L D
Sbjct: 1083 EVQAEAGASAMLSCEV-AQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADA 1141
Query: 1237 GFYSCSARSPLGQANTSLELRLEGVRVILAPEAA----VPEGAPITVTCADPAAHAPTLY 1292
G YSC A G S L + + + A E + V A T + A T
Sbjct: 1142 GEYSCEA----GGQRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEV 1197
Query: 1293 TWYHNGRWLQEGPAASLSFLVATR---------AHAGAYSCQAQDAQGTRSSRPAALQVL 1343
TWY +G+ L + TR A AG YSC+A + + + +
Sbjct: 1198 TWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEPKAV 1257
Query: 1344 YAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQ 1403
+A + V + R + A + A + C V ++ E+ DGK L++SS V A+G
Sbjct: 1258 FAKEQLVHNEVR-TEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRIEAAG----- 1310
Query: 1404 VARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNL 1463
R + Q AG+ T Q L + V +A + GA L
Sbjct: 1311 CMRQLVVQQAGQADAGEYTCEAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATL 1370
Query: 1464 SCRLLGGPGPVGNSTFAWFWNDRRLHAEP---------VPTLAFTHVARAQAGMYHCLAE 1514
SC + V W+ + ++L + L +A G Y C A
Sbjct: 1371 SCEVAQAQTEV-----TWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAG 1425
Query: 1515 LPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVA 1574
+ + +V++ + P V+ + G L C V + G +L
Sbjct: 1426 GQRLSFSLDVAEPKVVFAKEQPVHRE-VQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSF 1484
Query: 1575 SSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASN 1617
SS+ + + A R+ ++ + GEY C A +
Sbjct: 1485 SSK---------VRMEAVGCTRRLVVQQAGQAVAGEYSCEAGS 1518
Score = 94.7 bits (234), Expect = 7e-19
Identities = 362/1685 (21%), Positives = 573/1685 (34%), Gaps = 282/1685 (16%)
Query: 78 LVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTE 137
L+E R G+ + + E L + L+ DS +Y ++ V+G V + E
Sbjct: 2952 LLELRASGKHQ--PSQEGLTLRLTISALEKADSDTYTCDIGQAQSRAQLLVQGRRVHIIE 3009
Query: 138 EPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQW-QGQDPARSVTFNSQKFEPTGV 196
+ V++ EG+ F C + + W + P + N +P G
Sbjct: 3010 D------LEDVDVQEGSSATFRCR---ISPANYEPVHWFLDKTPLHANELNEIDAQPGGY 3060
Query: 197 GHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGE 256
H+ TL ++ +D G I + RA + + + K + ++ + I GE
Sbjct: 3061 -HVLTLRQ-LALKDSGTIY---FEAGDQRASAALRVTEKPSVFSREL----TDATITEGE 3111
Query: 257 LVTLTCQVNSSYPAVSSIKWLKDGVRLQTKT----------GVLHLPQAAWSDAGVYTCQ 306
+TL C+ ++ V W KDG L+ L + A D+G Y C+
Sbjct: 3112 DLTLVCETSTCDIPVC---WTKDGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKCE 3168
Query: 307 AENGVGSLV----SPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYK 362
A S + + P+ + +++V LE TL C + A W
Sbjct: 3169 AGGACSSSIVRVHARPVRFQEALKDLEV------LEGGAATLRCVLSSVAAP---VKWCY 3219
Query: 363 NHVLLEDAHSHTLR-----LHLATR----ADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413
+ +L ++LR L L R D+G Y C G + + V P
Sbjct: 3220 GNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSF----GDQTTSATLTVTALPAQ 3275
Query: 414 TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNS 473
E G L C + A + G L GD R+
Sbjct: 3276 FIGKLRNKEATEGATATLRCEL--SKAAPVEWRKGSETLRD--GD-----RYCLRQDGAM 3326
Query: 474 LRLEIRDLEETDSGEYKCSATNSLGNATSTL-DFHANAARLLISPAAEVVEGQAVTLSCR 532
L+IR L D+ EY C +A+ T+ A+ L E +EG TL C
Sbjct: 3327 CELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFIGRL--RHQESIEGATATLRCE 3384
Query: 533 SGLSPTPDARFSWYLNGALLHEGPGSSLLLPAA---------SSTDAGSYHCRARDGHSA 583
+ A W L +G SL A + DAG Y C + ++
Sbjct: 3385 LSKA----APVEWRKGRESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSCVCGEERTS 3440
Query: 584 SGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVV 643
A LTV P + FT L + A GA +L C + P R
Sbjct: 3441 ------ATLTVKALPAK--FTEGLRNEEAVEGA--TAMLWCELSKVAPVEW------RKG 3484
Query: 644 ATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSAT 703
+L G R + + ++I + + G YLC G TSAT
Sbjct: 3485 PENLRDG----------DRYILRQEGTRCELQICGLAMADAGEYLC----VCGQERTSAT 3530
Query: 704 FNGQ---ATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSW------FRNG---VLW 751
+ A + + +EG A L C ++ S A W R+G L
Sbjct: 3531 LTIRALPARFIEDVKNQEAREGATAVLQCELN-----SAAPVEWRKGSETLRDGDRYSLR 3585
Query: 752 AQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGH 811
G + + +A D Y+C E + + T L + + A +G
Sbjct: 3586 QDGTKCELQIRGLAMADTGEYSCVCGQERTSAMLTVRALPIKFTEGLRNEEAT----EGA 3641
Query: 812 MALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDS 871
A+ C + +A + + G L R + + +L++R L D+
Sbjct: 3642 TAVLRCELSK--MAPVEWWKGHETLRDG--------DRHSLRQDGARCELQIRGLVAEDA 3691
Query: 872 GSYRCEATNVLGSSNTSLFFQVR---GAWVQVSPSPELQEGQAVVLSCQVHTGVPE--GT 926
G Y C + G TS VR +++ + E EG L C++ P
Sbjct: 3692 GEYLC----MCGKERTSAMLTVRAMPSKFIEGLRNEEATEGDTATLWCELSKAAPVEWRK 3747
Query: 927 SYRWYRDGQP---LQESTSATLRFAAITLTQAGAYHCQ-AQAPGSATTSLAAPISLHVSY 982
+ RDG Q+ + L+ + + AG Y C Q SAT ++ A
Sbjct: 3748 GHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTSATLTVRA-------L 3800
Query: 983 APRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLH 1042
R + + G +L C + P + R + TL+G R
Sbjct: 3801 PARFIEDVKNQEAREGATAVLQCELSKAAPVEW------RKGSETLRG-------GDRYS 3847
Query: 1043 VAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQA---VNVQVWPGATVRE 1099
+ L+IHG + D G Y C GQ SA +A V + E
Sbjct: 3848 LRQDGTRCELQIHGLSVADTGEYSC----VCGQERTSATLTVRAPQPVFREPLQSLQAEE 3903
Query: 1100 GQLVNLTC--------LVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGV 1151
G L C +VW+ QL ++ + + + L ++ D Y C
Sbjct: 3904 GSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTC 3963
Query: 1152 GPPGRAPRLSRPITLDVLYAP-RNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAG- 1209
G + TL V AP R LR E G A + C + SR A +
Sbjct: 3964 GSQATS------ATLTVTAAPVRFLRELQHQEVDEGGTAHLCCEL-SRAGASVEWRKGSL 4016
Query: 1210 RLLASSTAASVPNTLRLEL--RGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAP 1267
+L + V + EL RG + D G Y+C Q+ SL +R+ +
Sbjct: 4017 QLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHT--QSMASLSVRVPRPKFKTRL 4074
Query: 1268 EAAVPEGAPITVTCADPA-AHAPTLYTWYHNGRWLQEGPAASLSFLVATR---------A 1317
++ E I C + A + + W G L GP + ATR
Sbjct: 4075 QSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEAK 4134
Query: 1318 HAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQ--CTVDSEPPA 1375
G Y+C T + AA + P+ ++ D+ + ++ C V
Sbjct: 4135 DTGEYACV------TGGQKTAASLRVTEPEVTIVRGLVDAEVTADEDVEFSCEVSRAGAT 4188
Query: 1376 ELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQ-VQDVPAGDDTYVCTAQNLLGSI 1434
+ G L S+ V +A G + + LRL+ V AG T LG+
Sbjct: 4189 GVQWCLQGLPL-QSNEVTEVAVRDGRI----HTLRLKGVTPEDAG------TVSFHLGNH 4237
Query: 1435 STIGRLQVEGARV-VAEPGLDV--PEGAALNLSCRLLGGPGPV------GNSTFAWFWND 1485
++ +L V V + EP DV EG + CRL G G A ND
Sbjct: 4238 ASSAQLTVRAPEVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMND 4297
Query: 1486 RRLHAEPVPTLAFTHVARAQAG--MYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVE 1543
+ + L V AG +H S+ L+V + VE
Sbjct: 4298 ITVEQGTLHLLTLHKVTLEDAGTVSFHV-------GTCSSEAQLKVTAKNTVVRGLENVE 4350
Query: 1544 PEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALR--VDIE 1601
G + +C++ +A+ T L V +S+ + V+ N LR + ++
Sbjct: 4351 ALEGGEALFECQLSQPEVAAHTWLLDDEPVHTSE--------NAEVVFFENGLRHLLLLK 4402
Query: 1602 ALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGL--LLLLLGL 1659
LRP D C + + G TS + VR W L +L L + G
Sbjct: 4403 NLRPQDS----CRVTFLAGDMVTSAFLTVRG-----------WRLEILEPLKNAAVRAGA 4447
Query: 1660 GACYT 1664
AC+T
Sbjct: 4448 QACFT 4452
Score = 85.9 bits (211), Expect = 3e-16
Identities = 282/1247 (22%), Positives = 418/1247 (33%), Gaps = 244/1247 (19%)
Query: 508 ANAARLLISPAAEVVE-GQAVTLSCRSGLSPTPDARFSWYLN------GA---LLHEGPG 557
+ A R L P A VV G+ TLSC+ +PTP SW + GA L +G
Sbjct: 7 SGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQV--SWEKDQQPVAAGARFRLAQDGDL 64
Query: 558 SSLLLPAASSTDAGSYHCRARD--GHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAG 615
L + + D+G Y CRAR+ G + + + P F R +
Sbjct: 65 YRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPT--SIRVR 122
Query: 616 AGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVE 675
G CRV P + R + P G PR++V + +
Sbjct: 123 EGSEATFRCRVGGSPRPAVSWSKDGRRLGE--PDG----------PRVRVEELGEASALR 170
Query: 676 IHNPLLEEEGLYLCEASNALGNASTSA----------TFNGQATVLAIAPSH-------- 717
I + G Y A N LG AS +A T + T A +H
Sbjct: 171 IRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAM 230
Query: 718 -----------------TLQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETV- 759
T+ EG A L+C V+ E W ++G L +G V
Sbjct: 231 RAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETV---WKKDGQLVTEGRRHVVY 287
Query: 760 ---------TLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP--PDRPKLSALLDMG 808
+L ++D LY C G Q + VL+ V P P + +L L++
Sbjct: 288 EDAQENFVLKILFCKQSDRGLYTCTASNLVG-QTYSSVLVVVREPAVPFKKRLQD-LEVR 345
Query: 809 QGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGL 868
+ A F+C V +P A F E L S ++ + E +L VR +
Sbjct: 346 EKESATFLCEV-PQPSTEAAWFKEETRLWAS--------AKYGIEEEGTERRLTVRNVSA 396
Query: 869 GDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSY 928
D Y CE S T V+G ++ P + C V VP G +
Sbjct: 397 DDDAVYICETPE---GSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFC-VELAVPVGPVH 452
Query: 929 RWYRDGQPL---------QESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLH 979
W R+ + + E T TL + L G A G TS +S
Sbjct: 453 -WLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMA---GDCQTSTQFCVS-- 506
Query: 980 VSYAPRHVTLTTLMD-TGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSS 1038
APR L +D R+ + S PP HG+R V T+ G +
Sbjct: 507 ---APRKPPLQPPVDPVVKARMESSVILSWSPPP------HGERPV--TIDGYLVEKKKL 555
Query: 1039 P-----RLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWP 1093
R H A T L + E + A N+ GQ S +F V + P
Sbjct: 556 GTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQ-SPYLEFPG---TVHLAP 611
Query: 1094 GATVR---------EGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSI-------PLP 1137
VR EG V + + + W+ DG Q L A S+
Sbjct: 612 KLAVRTPLKAVQAVEGGEVTFSVDLTVASAGE----WFLDG-QALKASSVYEIHCDRTRH 666
Query: 1138 NVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAP-----------------RNLRLTYL 1180
+T+R+ + G A + I ++V AP R L
Sbjct: 667 TLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQL 726
Query: 1181 LESHGGQLALVLCTVDSRP----PAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDE 1236
L Q A V D R P + AGR + L +R D
Sbjct: 727 LAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRV-------------LLVRDVARDDA 773
Query: 1237 GFYSCSARSPLGQANTSLELRLEGVRVILAPEAA-----VPEGAPITVTCADPAAHAPTL 1291
G Y C +R + +L ++G+ L + A G P C AH
Sbjct: 774 GLYECVSRG----GRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPAQFECETSEAHVHV- 828
Query: 1292 YTWYHNG--------RWLQE--GPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQ 1341
WY +G R+LQE G L TR G YSC+ + R + +
Sbjct: 829 -HWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPK 887
Query: 1342 VLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGH 1401
V++A + + + A + A + C V ++ E+ DGK L++SS V A+G
Sbjct: 888 VVFAKEQLARRKLQ-AEAGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVCMEATG--- 942
Query: 1402 VQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAAL 1461
R + Q AG+ + Q L + V VA + GA+
Sbjct: 943 --CTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASA 1000
Query: 1462 NLSCRLLGGPGPVGNSTFAWFWNDRRL------HAEPV---PTLAFTHVARAQAGMYHCL 1512
LSC + V W+ + ++L H E L + AG Y C
Sbjct: 1001 TLSCEVAQAQTEV-----MWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCE 1055
Query: 1513 AELPTGAAASAPVMLRVLYP----PKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHL 1568
A L + P K ++ V+ E G +L C V ++ +T +
Sbjct: 1056 AR-----GQRVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEV-AQAQTEVTWYK 1109
Query: 1569 GSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSA 1615
+ ++SS G + L P A + +D GEY C A
Sbjct: 1110 DGKKLSSSSKVGMEVKGCTRRLVLPQAGK--------ADAGEYSCEA 1148
Score = 81.6 bits (200), Expect = 6e-15
Identities = 277/1174 (23%), Positives = 409/1174 (34%), Gaps = 187/1174 (15%)
Query: 255 GELVTLTCQVNSSYPAVSSIKW------LKDG----VRLQTKTGVLHLPQAAWSDAGVYT 304
G L C+++ V+ ++W L+DG +R + L + A +DAG Y
Sbjct: 3464 GATAMLWCELSK----VAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYL 3519
Query: 305 CQA--ENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYK 362
C E +L + F+ +V+ A E T L C + AP + W K
Sbjct: 3520 CVCGQERTSATLTIRALPAR-FIEDVKNQEAR---EGATAVLQCELNSAAPVE----WRK 3571
Query: 363 NHVLLEDAHSHTLR---------LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL 413
L D ++LR + ADTG Y C V G ER+ + V P
Sbjct: 3572 GSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAMLTVRALPIK 3627
Query: 414 TPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSD-HSPRFSGTSGPN 472
E G +L C + H T D D HS R G
Sbjct: 3628 FTEGLRNEEATEGATAVLRCELSKMAPVEWWKGH------ETLRDGDRHSLRQDGAR--- 3678
Query: 473 SLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA-AEVVEGQAVTLSC 531
L+IR L D+GEY C +A T+ A ++ + E EG TL C
Sbjct: 3679 -CELQIRGLVAEDAGEYLCMCGKERTSAMLTV--RAMPSKFIEGLRNEEATEGDTATLWC 3735
Query: 532 R-SGLSPTPDARFSWYLNG----ALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGP 586
S +P + L +L +G L + + DAG Y C ++
Sbjct: 3736 ELSKAAPVEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTS--- 3792
Query: 587 SSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATS 646
A LTV P + F D+ A G +L C + P +
Sbjct: 3793 ---ATLTVRALPAR--FIE--DVKNQEAREGATAVLQCELSKAAPVEWRK---------- 3835
Query: 647 LPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNG 706
G T G R + + ++IH + + G Y C G TSAT
Sbjct: 3836 -----GSETLRG-GDRYSLRQDGTRCELQIHGLSVADTGEYSC----VCGQERTSATLTV 3885
Query: 707 QATVLAIA-PSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRNGV-LWAQGPLET---- 758
+A P +LQ EG+ A L C +S A W + G+ L A G E
Sbjct: 3886 RAPQPVFREPLQSLQAEEGSTATLQCELSEPTA----TVVWSKGGLQLQANGRREPRLQG 3941
Query: 759 ----VTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMAL 814
+ L + R D Y C G+Q ++ L P + ++ +G A
Sbjct: 3942 CTAELVLQDLQREDTGEYTCT----CGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAH 3997
Query: 815 FICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSY 874
C + SR A + G L ++Q + + +L VR + D+G Y
Sbjct: 3998 LCCEL-SRAGASVEWRKGSLQLFPC--------AKYQMVQDGAAAELLVRGVEQEDAGDY 4048
Query: 875 RCEATNVLGSSNTSLFFQV-RGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRD 933
C+ + S SL +V R + S E + G L CQ+ + G +W ++
Sbjct: 4049 TCDTGHT--QSMASLSVRVPRPKFKTRLQSLEQETGDIARLCCQL-SDAESGAVVQWLKE 4105
Query: 934 GQPLQESTSATLRFAAITLTQAGAYHCQAQAPGS---ATTSLAAPISLHVSYAPRHVTLT 990
G L +R T + + +A+ G T SL V+ VT+
Sbjct: 4106 GVELHAGPKYEMRSQGAT-RELLIHQLEAKDTGEYACVTGGQKTAASLRVTEP--EVTIV 4162
Query: 991 TLMDTGPGRLGLLLCRVDSDPPAQLRL---LHGDRLVASTLQGVGGPEGSSPRLHVAVAP 1047
GL+ V +D + G V LQG+ P S+ VAV
Sbjct: 4163 R---------GLVDAEVTADEDVEFSCEVSRAGATGVQWCLQGL--PLQSNEVTEVAVRD 4211
Query: 1048 NTLR-LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWP---GATVREGQLV 1103
+ L + G ED G S LG ++SA +A V + + EGQ
Sbjct: 4212 GRIHTLRLKGVTPEDAGT----VSFHLGNHASSAQLTVRAPEVTILEPLQDVQLSEGQDA 4267
Query: 1104 NLTCLV---------WTTHPAQLTYTWYQD-GQQRLDAHSIPLPNVTVRDATSYRCGVGP 1153
+ C + W L D ++ H + L VT+ DA + VG
Sbjct: 4268 SFQCRLSRASGQEARWALGGVPLQANEMNDITVEQGTLHLLTLHKVTLEDAGTVSFHVGT 4327
Query: 1154 PGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLA 1213
+L V+ N+ E+ G AL C + A +
Sbjct: 4328 CSSEAQLKVTAKNTVVRGLENV------EALEGGEALFECQLSQPEVAAHTWLLDDEPVH 4381
Query: 1214 SSTAASV---PNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRV-ILAP 1267
+S A V N LR L L+ +P+D SC G TS L + G R+ IL P
Sbjct: 4382 TSENAEVVFFENGLRHLLLLKNLRPQD----SCRVTFLAGDMVTSAFLTVRGWRLEILEP 4437
Query: 1268 --EAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQ----------EGPAASLSFLVAT 1315
AAV GA TC A +WY NG +Q +G +L A
Sbjct: 4438 LKNAAVRAGAQACFTCTLSEAVPVGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSAQ 4497
Query: 1316 RAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDA 1349
HAG + +DA S+R L + P+DA
Sbjct: 4498 PHHAGEVTFACRDA--VASARLTVLGLPDPPEDA 4529
Score = 77.4 bits (189), Expect = 1e-13
Identities = 299/1338 (22%), Positives = 457/1338 (34%), Gaps = 238/1338 (17%)
Query: 225 RAQSEIHLQVKYAPKGVKILLSP-SGRNILPGELVTLTCQVNSSYPAVSSIKWLKDG--- 280
+++S L V P + L P +GR + + V L+C PA +++W KD
Sbjct: 2455 KSRSSARLVVSDIPVVLTRPLEPKTGREL---QSVVLSCDFR---PAPKAVQWYKDDTPL 2508
Query: 281 -------VRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPA 333
+ L+ + L + + +DAGVY CQA GS S S + + +V+
Sbjct: 2509 SPSEKFKMSLEGQMAELRILRLMPADAGVYRCQA----GSAHS---STEVTVEAREVTVT 2561
Query: 334 GPI-----LENQTVTLVCNTPNEAPSDLRYSWYKN---------HVLLEDAHSHTLRLHL 379
GP+ E + C +E D W N H + HTL L
Sbjct: 2562 GPLQDAEATEEGWASFSCELSHE---DEEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKS 2618
Query: 380 ATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEP 439
RAD G V S R + V V L + G + L C VS+P
Sbjct: 2619 IQRADAGIVRASSLKVSTSAR---LEVRVKPVVFLKALDDLSAEERGTLA-LQCE-VSDP 2673
Query: 440 LATLVLSHGGHILA-STSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLG 498
A +V G L S D H+ +GT G L + D+ D+G Y C +
Sbjct: 2674 EAHVVWRKDGVQLGPSDKYDFLHT---AGTRG-----LVVHDVSPEDAGLYTCHVGSEET 2725
Query: 499 NATSTL-DFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALL----- 552
A + D H + L EV+EG++ + C D W + G +
Sbjct: 2726 RARVRVHDLHVGITKRL--KTMEVLEGESCSFECVLSHESASDPAM-WTVGGKTVGSSSR 2782
Query: 553 ----HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLD 608
+G L++ A+ +DAG S G +S A L V R+
Sbjct: 2783 FQATRQGRKYILVVREAAPSDAGEV------VFSVRGLTSKASLIV----RERPAAIIKP 2832
Query: 609 LDAAGAGAGRRGLLLCRVD-SDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTK 667
L+ G L C + + P KDR S + V
Sbjct: 2833 LEDQWVAPGEDVELRCELSRAGTPVHWL---KDRKAIRK-------------SQKYDVVC 2876
Query: 668 APNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANL 727
+ + I L++ G Y CE + AS + ++GT A
Sbjct: 2877 EGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEELTNLQVEEKGT-AVF 2935
Query: 728 TCNVSREAAGSPANFSWFRNGVL----------WAQGPLETVTLLPVARTDAALYACRIL 777
TC A A +W R G+L +G +T+ + + D+ Y C I
Sbjct: 2936 TCKTEHPA----ATVTW-RKGLLELRASGKHQPSQEGLTLRLTISALEKADSDTYTCDI- 2989
Query: 778 TEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLA 837
AQ +L+ L +D+ +G A F C + A + H
Sbjct: 2990 --GQAQSRAQLLVQGRRVHIIEDLED-VDVQEGSSATFRCRISP------ANYEPVHWFL 3040
Query: 838 TSLGPQVPSHGRFQAKAEANS---LKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894
+ P H + +A L +R+L L DSG+ EA G S +V
Sbjct: 3041 ----DKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEA----GDQRASAALRVT 3092
Query: 895 ---GAWVQVSPSPELQEGQAVVLSCQVHT-GVPEGTSYRWYRDGQPLQ---------EST 941
+ + + EG+ + L C+ T +P W +DG+ L+ E
Sbjct: 3093 EKPSVFSRELTDATITEGEDLTLVCETSTCDIP----VCWTKDGKTLRGSARCQLSHEGH 3148
Query: 942 SATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLG 1001
A L TL +G Y C +A G+ ++S+ + V + L L G
Sbjct: 3149 RAQLLITGATLQDSGRYKC--EAGGACSSSIVRVHARPVRFQEALKDLEVL----EGGAA 3202
Query: 1002 LLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061
L C V S A ++ +G+ ++ + EG+ L L + +D
Sbjct: 3203 TLRC-VLSSVAAPVKWCYGNNVLRPGDKYSLRQEGA-----------MLELVVRNLRPQD 3250
Query: 1062 EGVYICE-----ASNTLGQASASADFDAQAVNVQVWPGATVR-EGQLVNLTCLVWTTHPA 1115
G Y C S TL + A F + N + GAT +L + W
Sbjct: 3251 SGRYSCSFGDQTTSATLTVTALPAQFIGKLRNKEATEGATATLRCELSKAAPVEWRKGSE 3310
Query: 1116 QL----TYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYA 1171
L Y QDG + + + + DA Y C G R S +T+ + A
Sbjct: 3311 TLRDGDRYCLRQDGAM----CELQIRGLAMVDAAEYSCVCG----EERTSASLTIRPMPA 3362
Query: 1172 PRNLRLTYLLESHGGQLALVLCTVDSRPPAQL-----ALSHAGRLLASSTAASVPNTLRL 1226
RL + ES G A + C + P + +L R A L
Sbjct: 3363 HFIGRLRH-QESIEGATATLRCELSKAAPVEWRKGRESLRDGDRHSLRQDGA----VCEL 3417
Query: 1227 ELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVI----LAPEAAVPEGAPITVTC- 1281
++ G D G YSC G+ TS L ++ + L E AV EGA + C
Sbjct: 3418 QICGLAVADAGEYSCVC----GEERTSATLTVKALPAKFTEGLRNEEAV-EGATAMLWCE 3472
Query: 1282 ---ADPAAHAPTLYTWYHNGRWL--QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSR 1336
P R++ QEG L A AG Y C R
Sbjct: 3473 LSKVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYLCVC------GQER 3526
Query: 1337 PAALQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHDGKVLATSSGVHS 1394
+A + A + ++ AR + AV+QC ++S P E G +
Sbjct: 3527 TSATLTIRALPARFIEDVKNQEAREGATAVLQCELNSAAPVE-----------WRKGSET 3575
Query: 1395 LASGTGH-VQVARNALRLQVQDVPAGD-DTYVCTAQNLLGSISTIGRLQVEGARVVAEPG 1452
L G + ++ LQ++ + D Y C + G T L V + G
Sbjct: 3576 LRDGDRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAMLTVRALPIKFTEG 3631
Query: 1453 L---DVPEGAALNLSCRL 1467
L + EGA L C L
Sbjct: 3632 LRNEEATEGATAVLRCEL 3649
Score = 69.3 bits (168), Expect = 3e-11
Identities = 313/1506 (20%), Positives = 499/1506 (33%), Gaps = 280/1506 (18%)
Query: 255 GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYT 304
G TL+C+V A + + W KDG +L + V L + QA + AG Y+
Sbjct: 1457 GASTTLSCEVAQ---AQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYS 1513
Query: 305 CQAENGVGSLVSPPISLHIFMAEVQV-----SPAGPILENQTVTLVCNTPNEAPSDLRYS 359
C+A S +S H+ +AE + PA ++ + T + A + +
Sbjct: 1514 CEAG-------SQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATLSCEVAQAQTEVT 1566
Query: 360 WYKNHVLLEDAH---------SHTLRLHLATRADTGFYFCEVQN------VHGSERSGPV 404
WYK+ L + + L + A +AD G Y C+ + +H +E P
Sbjct: 1567 WYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHVAE---PK 1623
Query: 405 SVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPR 464
V P + A +AG L C V G + +S+ +
Sbjct: 1624 VVFAKEQPAHREVQA----EAGASATLSCEVAQAQTEVTWYKDGKKLSSSS--------K 1671
Query: 465 FSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAA----- 519
+ + RL ++ + D+GEY C A G + H IS
Sbjct: 1672 VRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQRLSFRLHVAELEPQISERPCRREP 1727
Query: 520 -EVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLH---------EGPGSSLLLPAASSTD 569
V E + + L+ L+ A +W +G + +G +L + A D
Sbjct: 1728 LVVKEHEDIILTAT--LATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLD 1785
Query: 570 AGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSD 629
+ Y CR A G P + + RL L+ G L C +
Sbjct: 1786 SAIYSCRV----GAEGQDFPVQVEEVAAK-----FCRL-LEPVCGELGGTVTLACELS-- 1833
Query: 630 PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLC 689
PA +++ R T L G R ++ + + + E+ G Y+C
Sbjct: 1834 -PACAEVVW--RCGNTQLRVG----------KRFQMVAEGPVRSLTVLGLRAEDAGEYVC 1880
Query: 690 EASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGV 749
E+ + +A + + ++ + +EG EA C VS S WFR+G
Sbjct: 1881 ESRDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVVSP----SDVAVVWFRDGA 1936
Query: 750 LWAQGPLETVTLLPVARTDAALYACRILTEAGA------QLSTPVLLSVLYPPDRPKLSA 803
L P E + + + + +L +AG S+ L V P K
Sbjct: 1937 LLQ--PSEKFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKL 1994
Query: 804 LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
+ ++ + +RP L LA G V H AE +L +
Sbjct: 1995 EPQTVEERSSVTLEVELTRPWPELRWTRNATALAP--GKNVEIH------AEGARHRLVL 2046
Query: 864 RELGLGDSGSYRCEATNVLGSSNTSLFFQVRGA-WVQVSPSPELQEGQAVVLSCQVHTGV 922
+G D G + CE + + L ++R V+ + E +E + Q+
Sbjct: 2047 HNVGFADRGFFGCETPD--DKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQLSHAD 2104
Query: 923 PEGTSYRWYRDGQPLQESTSATL--RFAAITLTQAGAYHCQA-----QAPGSATTSLAAP 975
+G+ W RDG Q+ + L R TLT +G + +A G T++
Sbjct: 2105 VDGS---WTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKAEGVHTSARLVV 2161
Query: 976 ISLHVSYA-PRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034
L VS++ P +TT + L C + S P +R L GV
Sbjct: 2162 TELPVSFSRPLQDVVTTEKEKVT-----LECEL-SRPNVDVRWLK---------DGVELR 2206
Query: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASA---------------- 1078
G + + +A L I+ D+GVY+C+A + AS
Sbjct: 2207 AGKT--MAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLA 2264
Query: 1079 -----------SADFDAQAVNVQVWPGATVR--------EGQLVNLTCLVWTTHPAQLTY 1119
+A+ AQ + V+ P VR E L C V A
Sbjct: 2265 EDAGEIQFVAENAESRAQ-LRVKELPVTLVRPLRDKIAMEKHRGVLECQV---SRASAQV 2320
Query: 1120 TWYQDGQQRLDA-----------HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV 1168
W++ Q+ + + +V D +Y C G + + +
Sbjct: 2321 RWFKGSQELQPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDAGDVKTSAQFF--VEEQS 2378
Query: 1169 LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLEL 1228
+ R L+ ++E RPP + L T + LE
Sbjct: 2379 ITIVRGLQDVTVMEPAPAWFECETSIPSVRPP---------KWLLGKTVLQAGGNVGLEQ 2429
Query: 1229 RGPQPRDEGFYSCSARS-----PLGQANTSLELRLEGVRVILAPEAAVPEGAPI-TVTCA 1282
G R +CS + +G++ +S L + + V+L G + +V +
Sbjct: 2430 EGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPLEPKTGRELQSVVLS 2489
Query: 1283 DPAAHAPTLYTWYHNGRWLQ---------EGPAASLSFLVATRAHAGAYSCQAQDAQGTR 1333
AP WY + L EG A L L A AG Y CQA A +
Sbjct: 2490 CDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHSST 2549
Query: 1334 SSRPAALQVLYAPQDAVLSSFRDSRA--RSMAVIQCTVDSEPPAELALSHDGKVLATSSG 1391
A +V V +D+ A A C + E E+ S +G L S
Sbjct: 2550 EVTVEAREV------TVTGPLQDAEATEEGWASFSCELSHE-DEEVEWSLNGMPLYNDSF 2602
Query: 1392 VHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEP 1451
G H V ++ R D + A +L +ST RL+V VV
Sbjct: 2603 HEISHKGRRHTLVLKSIQRA---------DAGIVRASSL--KVSTSARLEVRVKPVVFLK 2651
Query: 1452 GLD---VPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQ--- 1505
LD E L L C + V W + P F H A +
Sbjct: 2652 ALDDLSAEERGTLALQCEVSDPEAHV-------VWRKDGVQLGPSDKYDFLHTAGTRGLV 2704
Query: 1506 --------AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVD 1557
AG+Y C A L V + TM V +L
Sbjct: 2705 VHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHESA 2764
Query: 1558 SEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASN 1617
S+P A T +G + V SS A + ++L + PSD GE + S
Sbjct: 2765 SDP-AMWT--VGGKTVGSSSRFQATRQGRKYILV--------VREAAPSDAGEVVFSVRG 2813
Query: 1618 VLGSAS 1623
+ AS
Sbjct: 2814 LTSKAS 2819
Score = 68.9 bits (167), Expect = 4e-11
Identities = 266/1211 (21%), Positives = 410/1211 (33%), Gaps = 218/1211 (18%)
Query: 509 NAARLLISPAAEVV----------EGQAVTLSCRSGLSPTPDARFSWYLNGALLH----- 553
++ARL++S V+ E Q+V LSC P P A WY + L
Sbjct: 2458 SSARLVVSDIPVVLTRPLEPKTGRELQSVVLSC--DFRPAPKA-VQWYKDDTPLSPSEKF 2514
Query: 554 ----EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDL 609
EG + L + DAG Y C+A HS++ V R+ T T L
Sbjct: 2515 KMSLEGQMAELRILRLMPADAGVYRCQAGSAHSST--------EVTVEAREVTVTGPLQ- 2565
Query: 610 DAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAP 669
DA G +L H+D V SL G +
Sbjct: 2566 DAEATEEGWASF-----------SCELSHEDEEVEWSL---NGMPLYNDSFHEISHKGRR 2611
Query: 670 NLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTC 729
+ L ++ + + G+ + +A + A+ + GT A L C
Sbjct: 2612 HTLVLK--SIQRADAGIVRASSLKVSTSARLEVRVKPVVFLKALDDLSAEERGTLA-LQC 2668
Query: 730 NVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVART-----------DAALYACRILT 778
VS A+ W ++GV GP + L A T DA LY C + +
Sbjct: 2669 EVS----DPEAHVVWRKDGV--QLGPSDKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGS 2722
Query: 779 EAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLAT 838
E + V + L+ +L + ++ +G F C + + A++ T
Sbjct: 2723 E---ETRARVRVHDLHVGITKRLKTM-EVLEGESCSFECVLSHESASDPAMW-------T 2771
Query: 839 SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV 898
G V S RFQA + L VRE D+G + +S SL + R A +
Sbjct: 2772 VGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGEVVFSVRGL--TSKASLIVRERPAAI 2829
Query: 899 QVSPSPE--LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQ---------ESTSATLRF 947
+ P + + G+ V L C++ GT W +D + ++ E T A L
Sbjct: 2830 -IKPLEDQWVAPGEDVELRCELSRA---GTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVI 2885
Query: 948 AAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVT--LTTLMDTGPGRLGLLLC 1005
+L AG Y C+ +A S SLHV T LT L G + C
Sbjct: 2886 RGASLKDAGEYTCEVEASKSTA-------SLHVEEKANCFTEELTNLQVEEKG-TAVFTC 2937
Query: 1006 RVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVY 1065
+ + P A + G L+ G + S L TLRL I D Y
Sbjct: 2938 KTE-HPAATVTWRKG----LLELRASGKHQPSQEGL-------TLRLTISALEKADSDTY 2985
Query: 1066 ICEASNTLGQASASADFDAQAVNVQV---WPGATVREGQLVNLTCLVWTTHPAQL-TYTW 1121
C+ +GQA + A Q V + V+EG C + PA W
Sbjct: 2986 TCD----IGQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSATFRCRI---SPANYEPVHW 3038
Query: 1122 YQDGQ-------QRLDA-----HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVL 1169
+ D +DA H + L + ++D+ + G R S + +
Sbjct: 3039 FLDKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEAGD----QRASAALRVTEK 3094
Query: 1170 YAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVP---NTLRL 1226
+ + LT + G L LV T P + + G+ L S + + +L
Sbjct: 3095 PSVFSRELTDATITEGEDLTLVCETSTCDIP--VCWTKDGKTLRGSARCQLSHEGHRAQL 3152
Query: 1227 ELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAA 1286
+ G +D G Y C A + + R + L + V EG T+ C +
Sbjct: 3153 LITGATLQDSGRYKCEAGGACSSSIVRVHARPVRFQEAL-KDLEVLEGGAATLRCVLSSV 3211
Query: 1287 HAPTLYTWYHN-------GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAA 1339
AP + + +N QEG L +G YSC D + A
Sbjct: 3212 AAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSFGD-----QTTSAT 3266
Query: 1340 LQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLAS 1397
L V P + R+ A + A ++C + P E G +L
Sbjct: 3267 LTVTALPAQ-FIGKLRNKEATEGATATLRCELSKAAPVE-----------WRKGSETLRD 3314
Query: 1398 GTGHVQVARNAL-RLQVQD---VPAGDDTYVCTAQNLLGSIST-------IGRLQVEGAR 1446
G + A+ LQ++ V A + + VC + S++ IGRL+ +
Sbjct: 3315 GDRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFIGRLRHQ--- 3371
Query: 1447 VVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHA----EPVPTLAFTHVA 1502
+ EGA L C L PV D H+ V L +A
Sbjct: 3372 -------ESIEGATATLRCE-LSKAAPVEWRKGRESLRDGDRHSLRQDGAVCELQICGLA 3423
Query: 1503 RAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLA 1562
A AG Y C+ G ++ + P K + E G +L C + +A
Sbjct: 3424 VADAGEYSCVC----GEERTSATLTVKALPAKFTEGLRNEEAVEGATAMLWCELSK--VA 3477
Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
+ G P+ + + I L +D GEY+C V G
Sbjct: 3478 PVEWRKG--------PENLRDGDRYILRQEGTRCELQICGLAMADAGEYLC----VCGQE 3525
Query: 1623 STSTYFGVRAL 1633
TS +RAL
Sbjct: 3526 RTSATLTIRAL 3536
Score = 67.8 bits (164), Expect = 9e-11
Identities = 122/500 (24%), Positives = 189/500 (37%), Gaps = 80/500 (16%)
Query: 138 EPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVG 197
EP+V A + + ST C Q + + + ++F+S K VG
Sbjct: 1437 EPKV-VFAKEQPVHREVQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSFSS-KVRMEAVG 1494
Query: 198 HLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILP--G 255
L + Q G+ + + S + HL V PK V P+ R + G
Sbjct: 1495 CTRRLVV----QQAGQAVAGEYSCEAGSQRLSFHLHVA-EPKAVFAKEQPASREVQAEAG 1549
Query: 256 ELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTC 305
TL+C+V A + + W KDG +L + + V L + +A +DAG Y+C
Sbjct: 1550 TSATLSCEVAQ---AQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSC 1606
Query: 306 QAENGVGSLVSPPISLHIFMAEVQV-----SPAGPILENQ---TVTLVCNTPNEAPSDLR 357
+A + +S H+ +AE +V PA ++ + + TL C A +
Sbjct: 1607 KAGD-------QRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEV---AQAQTE 1656
Query: 358 YSWYKNHVLLEDAH---------SHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVV 408
+WYK+ L + + L + A +AD G Y CE G +R +S +
Sbjct: 1657 VTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA----GGQR---LSFRL 1709
Query: 409 NHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSG-DSDHSPRFSG 467
+ L P ++ + LV H ++ ATL + G + S R
Sbjct: 1710 HVAELEPQISERPCRREPLVVKEHEDIILT--ATLATPSAATVTWLKDGVEIRRSKRHET 1767
Query: 468 TSGPNSLRLEIRDLEETDSGEYKCSA-TNSLGNATSTLDFHANAARLLISPAAEVVEGQA 526
S ++ L + + DS Y C + A RLL E+ G
Sbjct: 1768 ASQGDTHTLTVHGAQVLDSAIYSCRVGAEGQDFPVQVEEVAAKFCRLLEPVCGEL--GGT 1825
Query: 527 VTLSCRSGLSPTPDARFSWYLNGALLH---------EGPGSSLLLPAASSTDAGSYHCRA 577
VTL+C LSP A W L EGP SL + + DAG Y C +
Sbjct: 1826 VTLACE--LSPAC-AEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCES 1882
Query: 578 RDGHSASGPSSPAVLTVLYP 597
RD H++ A LTV P
Sbjct: 1883 RDDHTS------AQLTVSVP 1896
Score = 58.5 bits (140), Expect = 5e-08
Identities = 219/971 (22%), Positives = 342/971 (35%), Gaps = 172/971 (17%)
Query: 172 RLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIH 231
R Q + P RS+T + E G ++ S DH QL+V+
Sbjct: 1853 RFQMVAEGPVRSLTVLGLRAEDAGE------YVCESRDDH---TSAQLTVS--------- 1894
Query: 232 LQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ------- 284
P+ VK + S G T C V+ P+ ++ W +DG LQ
Sbjct: 1895 -----VPRVVKFMSGLSTVVAEEGGEATFQCVVS---PSDVAVVWFRDGALLQPSEKFAI 1946
Query: 285 TKTGVLH---LPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQT 341
+++G H + DAG T +AE G S + + + + ++ P + E +
Sbjct: 1947 SQSGASHSLTISDLVLEDAGQITVEAE-GASSSAALRVREAPVLFKKKLEPQ-TVEERSS 2004
Query: 342 VTLVCNTPNEAPSDLRYSWY-------KNHVLLEDAHSHTLRLHLATRADTGFYFCEVQN 394
VTL P +LR++ KN + + H L LH AD GF+ CE +
Sbjct: 2005 VTLEVELTRPWP-ELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCETPD 2063
Query: 395 VHGSERSGPVSVVVNHPPLTPVLTAFLETQAGL----VGILHCSVVSEPLATLVLSHGGH 450
+ ++V + L L A + G V + H V + G
Sbjct: 2064 ---DKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQLSHADVDGS------WTRDG- 2113
Query: 451 ILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG--EYKCSATNSLGNATSTLDFHA 508
L G + H GP L + L DSG +K ++ T +
Sbjct: 2114 -LRFQQGPTCHL----AVRGPMHT-LTLSGLRPEDSGLMVFKAEGVHTSARLVVT-ELPV 2166
Query: 509 NAARLLISPAAEVV--EGQAVTLSCRSGLSPTPDARFSWYLNG---------ALLHEGPG 557
+ +R P +VV E + VTL C P D R W +G A+ +G
Sbjct: 2167 SFSR----PLQDVVTTEKEKVTLECELS-RPNVDVR--WLKDGVELRAGKTMAIAAQGAC 2219
Query: 558 SSLLLPAASSTDAGSYHCRARDGHS-ASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGA 616
SL + D G Y C A D S AS T++Y R+ ++ A
Sbjct: 2220 RSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIY--RRVLAEDAGEIQFVAENA 2277
Query: 617 GRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCS--------------PR 662
R L RV P ++ L +D++ C + P+
Sbjct: 2278 ESRAQL--RVKELPVTLVRPL-RDKIAMEKHRGVLECQVSRASAQVRWFKGSQELQPGPK 2334
Query: 663 MKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATF---NGQATVLAIAPSHTL 719
++ ++ I + E+E Y C+A G+ TSA F T++ T+
Sbjct: 2335 YELVSDGLYRKLIISDVHAEDEDTYTCDA----GDVKTSAQFFVEEQSITIVRGLQDVTV 2390
Query: 720 QEGTEANLTCNVSREAAGSPANFSWFRNG-VLWAQGPLE-----TVTLLPVARTDAALYA 773
E A C S + P W VL A G + TV L + RT + +
Sbjct: 2391 MEPAPAWFECETSIPSVRPP---KWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTG 2447
Query: 774 CRILTEAGAQLSTPVLLS----VLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLAL 829
T ++ S +++S VL P PK L + + D RP
Sbjct: 2448 PVHFTVGKSRSSARLVVSDIPVVLTRPLEPKTGRELQS-------VVLSCDFRPAPKAVQ 2500
Query: 830 FHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSL 889
++ + P PS +F+ E +L + L D+G YRC+A GS+++S
Sbjct: 2501 WYKDDT------PLSPSE-KFKMSLEGQMAELRILRLMPADAGVYRCQA----GSAHSST 2549
Query: 890 FFQVRGAWVQVSPSPELQEGQA-----VVLSCQVHTGVPEGTSYRWYRDGQPLQEST--S 942
V +V+ + LQ+ +A SC++ E W +G PL +
Sbjct: 2550 EVTVEAR--EVTVTGPLQDAEATEEGWASFSCELS---HEDEEVEWSLNGMPLYNDSFHE 2604
Query: 943 ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL 1002
+ + TL A +++ ++ L V P V L L D G
Sbjct: 2605 ISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKP-VVFLKALDDLSAEERGT 2663
Query: 1003 LLCRVD-SDPPAQLRLLHGDRLVASTLQGVG-GPEGSSPRLHVAVAPNTLRLEIHGAMLE 1060
L + + SDP A V GV GP LH A T L +H E
Sbjct: 2664 LALQCEVSDPEAH---------VVWRKDGVQLGPSDKYDFLHTA---GTRGLVVHDVSPE 2711
Query: 1061 DEGVYICEASN 1071
D G+Y C +
Sbjct: 2712 DAGLYTCHVGS 2722
Score = 57.8 bits (138), Expect = 9e-08
Identities = 79/348 (22%), Positives = 119/348 (34%), Gaps = 82/348 (23%)
Query: 1339 ALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASG 1398
A + L P+ V+S +D A + C + P +++ D + +A + G
Sbjct: 9 APRFLTRPKAFVVSVGKD------ATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDG 62
Query: 1399 TGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQVEGARVVAEPG----- 1452
+ RL + D+ GD YVC A+N +G LQV+ AE
Sbjct: 63 --------DLYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLL 114
Query: 1453 ----LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQA-- 1506
+ V EG+ CR+ G P P +W + RRL P + + A A
Sbjct: 115 RPTSIRVREGSEATFRCRVGGSPRPA----VSWSKDGRRLGEPDGPRVRVEELGEASALR 170
Query: 1507 ---------GMYHCLAELPTGAAASAPVML------------------------------ 1527
G Y AE P GAA++A ++
Sbjct: 171 IRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAM 230
Query: 1528 ----RVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPA 1583
PP T T V G L C V EP +LV +
Sbjct: 231 RAEGAPASPPSTGTRTCTVTE--GKHARLSCYVTGEPKPETVWKKDGQLVTEGR------ 282
Query: 1584 EPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVR 1631
H+ + + I + SD+G Y C+ASN++G +S VR
Sbjct: 283 -RHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVR 329
Score = 54.3 bits (129), Expect = 1e-06
Identities = 54/192 (28%), Positives = 78/192 (40%), Gaps = 24/192 (12%)
Query: 909 GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST----------SATLRFAAITLTQAGAY 958
G+ V L+C+V TG P+ WY+DG+ +Q S L ++T +G Y
Sbjct: 6028 GETVKLACRV-TGTPKPV-ISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQY 6085
Query: 959 HCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLL 1018
C A + ++L + V PR V G C ++ P Q+R
Sbjct: 6086 MCFAASAAGNCSTLG---KILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWY 6142
Query: 1019 HGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASA 1078
L+ + G S PR + V L I A ED G+Y CE N LG A A
Sbjct: 6143 KDGALLTT---GNKFQTLSEPRSGLLV------LVIRAASKEDLGLYECELVNRLGSARA 6193
Query: 1079 SADFDAQAVNVQ 1090
SA+ Q+ +Q
Sbjct: 6194 SAELRIQSPMLQ 6205
Score = 49.3 bits (116), Expect = 3e-05
Identities = 57/198 (28%), Positives = 86/198 (43%), Gaps = 31/198 (15%)
Query: 524 GQAVTLSCRSGLSPTPDARFSWYLNGA--------LLHEGPGSS--LLLPAASSTDAGSY 573
G+ V L+CR ++ TP SWY +G +L E P S L+L + + D+G Y
Sbjct: 6028 GETVKLACR--VTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQY 6085
Query: 574 HCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPAR 633
C A +A S+ + V PPR F ++ A+ G C ++ P +
Sbjct: 6086 MCFAAS--AAGNCSTLGKILVQVPPR---FVNKVR--ASPFVEGEDAQFTCTIEGAPYPQ 6138
Query: 634 LQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASN 693
++ +KD + T+ G T PR LL + I E+ GLY CE N
Sbjct: 6139 IRW-YKDGALLTT---GNKFQTLS--EPRS------GLLVLVIRAASKEDLGLYECELVN 6186
Query: 694 ALGNASTSATFNGQATVL 711
LG+A SA Q+ +L
Sbjct: 6187 RLGSARASAELRIQSPML 6204
Score = 47.0 bits (110), Expect = 2e-04
Identities = 96/460 (20%), Positives = 154/460 (33%), Gaps = 82/460 (17%)
Query: 718 TLQEGTEANLTCNVSREAAGSPAN-FSWFRNGVLWAQGPLETVTLLP----------VAR 766
T + G L C V+ G+P SW+++G P + P +
Sbjct: 6024 TAELGETVKLACRVT----GTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTG 6079
Query: 767 TDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLAL 826
D+ Y C + AG ST + V PP +G A F CT++ P
Sbjct: 6080 VDSGQYMCFAASAAG-NCSTLGKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQ 6138
Query: 827 LALFHGEHLLATSLGPQVPSHGRFQAKAEANS--LKLEVRELGLGDSGSYRCEATNVLGS 884
+ + LL T +FQ +E S L L +R D G Y CE N LGS
Sbjct: 6139 IRWYKDGALLTTG--------NKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGS 6190
Query: 885 SNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSAT 944
+ S +++ +Q ++ A V + E TS G ++
Sbjct: 6191 ARASAELRIQSPMLQAQEQCHREQLVAAVEDTTLERADQEVTSVLKRLLGPKAPGPSTGD 6250
Query: 945 LRFAAITLTQAGAYHCQAQAPGSATTSLAAPI--SLHVSYAPRHVTLTTLMDTGPGRLGL 1002
L G C AP T P+ + P V L+ GP
Sbjct: 6251 L---------TGPGPCPRGAPALQETGSQPPVTGTSEAPAVPPRVP-QPLLHEGP----- 6295
Query: 1003 LLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED- 1061
+ +P A R + V ++G P L ++H ++ +
Sbjct: 6296 -----EQEPEAIARA--QEWTVPIRMEGAAWP---------GAGTGELLWDVHSHVVRET 6339
Query: 1062 -EGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYT 1120
+ Y +A +T + +VQ G T + ++ Q + T
Sbjct: 6340 TQRTYTYQAIDT--HTARPPSMQVTIEDVQAQTGGTAQFEAIIE--------GDPQPSVT 6389
Query: 1121 WYQDGQQRLDA-----------HSIPLPNVTVRDATSYRC 1149
WY+D Q +D+ +S+ L +V +DA Y C
Sbjct: 6390 WYKDSVQLVDSTRLSQQQEGTTYSLVLRHVASKDAGVYTC 6429
Score = 46.6 bits (109), Expect = 2e-04
Identities = 49/182 (26%), Positives = 72/182 (39%), Gaps = 23/182 (12%)
Query: 1096 TVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ-RLDAHSIP-----------LPNVTVRD 1143
T G+ V L C V T + +WY+DG+ ++D H I L ++T D
Sbjct: 6024 TAELGETVKLACRV--TGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVD 6081
Query: 1144 ATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQ 1202
+ Y C G L + + V PR + G+ A CT++ P Q
Sbjct: 6082 SGQYMCFAASAAGNCSTLGKIL---VQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQ 6138
Query: 1203 LALSHAGRLLASST---AASVPNT--LRLELRGPQPRDEGFYSCSARSPLGQANTSLELR 1257
+ G LL + S P + L L +R D G Y C + LG A S ELR
Sbjct: 6139 IRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELR 6198
Query: 1258 LE 1259
++
Sbjct: 6199 IQ 6200
Score = 40.8 bits (94), Expect = 0.011
Identities = 49/186 (26%), Positives = 73/186 (39%), Gaps = 22/186 (11%)
Query: 340 QTVTLVCNTPNEAPSDLRYSWYKN---------HVLLEDAH-SHTLRLHLATRADTGFYF 389
+TV L C + SWYK+ H+L+ED S L L T D+G Y
Sbjct: 6029 ETVKLACRVTGTPKPVI--SWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYM 6086
Query: 390 CEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGG 449
C + G+ S ++V PP G C++ P + G
Sbjct: 6087 CFAASAAGN-CSTLGKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDG 6145
Query: 450 HILASTSGDSDHSPRFSGTSGPNS--LRLEIRDLEETDSGEYKCSATNSLGNATSTLDFH 507
+L T+G+ +F S P S L L IR + D G Y+C N LG+A ++ +
Sbjct: 6146 ALL--TTGN-----KFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELR 6198
Query: 508 ANAARL 513
+ L
Sbjct: 6199 IQSPML 6204
Score = 40.0 bits (92), Expect = 0.019
Identities = 88/430 (20%), Positives = 139/430 (32%), Gaps = 101/430 (23%)
Query: 639 KDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEE-------------- 684
+++ V P C G P ++ K LL + H + E++
Sbjct: 5133 QNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPA 5192
Query: 685 --GLYLCEASNALGNASTSATFNGQAT-----VLAIAP------------SHTLQEGTEA 725
G+Y C A N++G +ST A T A A S QEGTE+
Sbjct: 5193 DMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTES 5252
Query: 726 NLT----------------------CNVSREAAGSPA-NFSWFRNGV---------LWAQ 753
+ G PA WF++G + +
Sbjct: 5253 TTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDK 5312
Query: 754 GPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQ---- 809
L T+ ++ V R D+ YA I GA S+ LL + PD P+ D+ +
Sbjct: 5313 KILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLL--VRGPDEPEEKPASDVHEQLVP 5370
Query: 810 --------------GHMALFICTVDSRPLALLALFHGEHLLATS-LGPQVPSHGRFQAKA 854
G F V+ RP+ + E +GP P + +
Sbjct: 5371 PRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPG---YTVAS 5427
Query: 855 EANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVL 914
A L + ++G G+Y C A+N G + S V G P E QE L
Sbjct: 5428 SAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGL-----PKVEEQEKVKEAL 5482
Query: 915 SCQVHTGVPEGTSYRWYR-------DGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGS 967
G + S + GQ +E +A ++L + G +
Sbjct: 5483 ISTFLQGTTQAISAQGLETASFADLGGQRKEEPLAAKEALGHLSLAEVGTEEFLQKLTSQ 5542
Query: 968 ATTSLAAPIS 977
T ++A I+
Sbjct: 5543 ITEMVSAKIT 5552
Score = 40.0 bits (92), Expect = 0.019
Identities = 42/188 (22%), Positives = 70/188 (37%), Gaps = 27/188 (14%)
Query: 1458 GAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVP----------TLAFTHVARAQAG 1507
G + L+CR+ G P PV +W+ + + + +P L + +G
Sbjct: 6028 GETVKLACRVTGTPKPV----ISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSG 6083
Query: 1508 MYHCLAELPTGAAASAPVMLRVLYPPKTPTMM---VFVEPEGGLRGILDCRVDSEPLASL 1564
Y C A G ++ +L V PP+ + FVE E C ++ P +
Sbjct: 6084 QYMCFAASAAGNCSTLGKIL-VQVPPRFVNKVRASPFVEGEDAQ---FTCTIEGAPYPQI 6139
Query: 1565 TLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSAST 1624
+ L+ + +EP +L + I A D G Y C N LGSA
Sbjct: 6140 RWYKDGALLTTGNKFQTLSEPRSGLLV------LVIRAASKEDLGLYECELVNRLGSARA 6193
Query: 1625 STYFGVRA 1632
S +++
Sbjct: 6194 SAELRIQS 6201
Score = 40.0 bits (92), Expect = 0.019
Identities = 26/80 (32%), Positives = 39/80 (48%), Gaps = 13/80 (16%)
Query: 248 SGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVL-----------HLPQAA 296
S ++ G+ VTL CQV S+ PA + W KDG L++ + VL +
Sbjct: 7470 SDETVVLGQSVTLACQV-SAQPAAQAT-WSKDGAPLESSSRVLISATLKNFQLLTILVVV 7527
Query: 297 WSDAGVYTCQAENGVGSLVS 316
D GVYTC N +G++ +
Sbjct: 7528 AEDLGVYTCSVSNALGTVTT 7547
Score = 37.4 bits (85), Expect = 0.13
Identities = 31/94 (32%), Positives = 46/94 (48%), Gaps = 9/94 (9%)
Query: 1365 IQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGD-DTY 1423
+ C V ++P A+ S DG L +SS V L S T +N L + V A D Y
Sbjct: 7482 LACQVSAQPAAQATWSKDGAPLESSSRV--LISAT-----LKNFQLLTILVVVAEDLGVY 7534
Query: 1424 VCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPE 1457
C+ N LG+++T G L+ + R + P D+ E
Sbjct: 7535 TCSVSNALGTVTTTGVLR-KAERPSSSPCPDIGE 7567
Score = 36.6 bits (83), Expect = 0.21
Identities = 25/76 (32%), Positives = 35/76 (46%), Gaps = 4/76 (5%)
Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLR----LELRGPQPRDEGFYSC 1241
GQ + C V ++P AQ S G L SS+ + TL+ L + D G Y+C
Sbjct: 7477 GQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLTILVVVAEDLGVYTC 7536
Query: 1242 SARSPLGQANTSLELR 1257
S + LG T+ LR
Sbjct: 7537 SVSNALGTVTTTGVLR 7552
Score = 36.2 bits (82), Expect = 0.28
Identities = 42/191 (21%), Positives = 75/191 (39%), Gaps = 25/191 (13%)
Query: 1274 GAPITVTCADPAAHAPTLYTWYHNGRWLQ--------EGPAASLSFLV--ATRAHAGAYS 1323
G + + C P + +WY +G+ +Q E P S + ++ T +G Y
Sbjct: 6028 GETVKLACRVTGTPKPVI-SWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYM 6086
Query: 1324 CQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSR--ARSMAVIQCTVDSEPPAELALSH 1381
C A A G S+ ++L ++ R S A CT++ P ++
Sbjct: 6087 CFAASAAGNCSTLG---KILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYK 6143
Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD--TYVCTAQNLLGSISTIGR 1439
DG +L T + +L+ R+ L + V + +D Y C N LGS
Sbjct: 6144 DGALLTTGNKFQTLSE-------PRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAE 6196
Query: 1440 LQVEGARVVAE 1450
L+++ + A+
Sbjct: 6197 LRIQSPMLQAQ 6207
Score = 34.3 bits (77), Expect = 1.1
Identities = 74/336 (22%), Positives = 111/336 (33%), Gaps = 73/336 (21%)
Query: 520 EVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP----------GSSLLLPAASSTD 569
EV +G V+ C P P R W+ +G LL E G L++ A D
Sbjct: 5136 EVQDGYPVSFDCVVTGQPMPSVR--WFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPAD 5193
Query: 570 AGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRV--- 626
G Y C A + S S+ A L V + T D + + +G L R
Sbjct: 5194 MGVYRCLAENSMGVS--STKAELRV--DLTSTDYDTAADATESSSYFSAQGYLSSREQEG 5249
Query: 627 ------DSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRM---------------KV 665
+ P ++ L +V + + G +PR+ ++
Sbjct: 5250 TESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRM 5309
Query: 666 TKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATF-----------NGQATVLAIA 714
T L +EI + E+ G Y SNA+G A +SA +
Sbjct: 5310 TDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLV 5369
Query: 715 PSHTLQEGTE------ANLTCNVSREAAGSPANFSWFR----NGVLW-----------AQ 753
P L+ T +++T +V E P W R GVLW +
Sbjct: 5370 PPRMLERFTPKKVKKGSSITFSVKVEGRPVP-TVHWLREEAERGVLWIGPDTPGYTVASS 5428
Query: 754 GPLETVTLLPVARTDAALYACRILTEAGAQLSTPVL 789
++ LL V R Y C AG L + L
Sbjct: 5429 AQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASL 5464
Score = 33.5 bits (75), Expect = 1.8
Identities = 74/337 (21%), Positives = 114/337 (33%), Gaps = 79/337 (23%)
Query: 255 GELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAA------------WSDAGV 302
G+ + L C V S A +WLKDGV L T H+ Q +DAG
Sbjct: 4912 GDALRLECVVASK--ADVRARWLKDGVEL-TDGRHHHIDQLGDGTCSLLITGLDRADAGC 4968
Query: 303 YTCQAENGVGSLV-SPPISLHIFMAEVQVSPAG-----------------------PILE 338
YTCQ N G + S + + +E + S G + +
Sbjct: 4969 YTCQVSNKFGQVTHSACVVVSGSESEAESSSGGELDDAFRRAARRLHRLFRTKSPAEVSD 5028
Query: 339 NQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRA-----------DTGF 387
+ P E + Y+ ED H +R T A T
Sbjct: 5029 EELFLSADEGPAEPEEPADWQTYR-----EDEHFICIRFEALTEARQAVTRFQEMFATLG 5083
Query: 388 YFCEVQNVHGSERSGPVSV-------VVNHPPLTPVLTA-----FL------ETQAGLVG 429
E++ V R + + VV PL +LT+ FL E Q G
Sbjct: 5084 IGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPV 5143
Query: 430 ILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEY 489
C V +P+ ++ G +L + DH G + +L I + D G Y
Sbjct: 5144 SFDCVVTGQPMPSVRWFKDGKLLE----EDDHYMINEDQQGGH--QLIITAVVPADMGVY 5197
Query: 490 KCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQA 526
+C A NS+G +++ + + AA+ E +
Sbjct: 5198 RCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSS 5234
Score = 33.5 bits (75), Expect = 1.8
Identities = 25/77 (32%), Positives = 33/77 (42%), Gaps = 13/77 (16%)
Query: 1552 LDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASP---NALRVDIEALRPSDQ 1608
L C+V ++P A T GAP E VL S N + I + D
Sbjct: 7482 LACQVSAQPAAQATW----------SKDGAPLESSSRVLISATLKNFQLLTILVVVAEDL 7531
Query: 1609 GEYICSASNVLGSASTS 1625
G Y CS SN LG+ +T+
Sbjct: 7532 GVYTCSVSNALGTVTTT 7548
Score = 33.1 bits (74), Expect = 2.4
Identities = 30/94 (31%), Positives = 44/94 (46%), Gaps = 21/94 (22%)
Query: 234 VKYAPKGV-KILLSPSGRNILPGELVTLTCQVNSS-YPAVSSIKWLKDGVRLQT------ 285
V+ P+ V K+ SP + GE TC + + YP I+W KDG L T
Sbjct: 6104 VQVPPRFVNKVRASP----FVEGEDAQFTCTIEGAPYP---QIRWYKDGALLTTGNKFQT 6156
Query: 286 ----KTG--VLHLPQAAWSDAGVYTCQAENGVGS 313
++G VL + A+ D G+Y C+ N +GS
Sbjct: 6157 LSEPRSGLLVLVIRAASKEDLGLYECELVNRLGS 6190
Score = 33.1 bits (74), Expect = 2.4
Identities = 20/53 (37%), Positives = 26/53 (49%), Gaps = 10/53 (18%)
Query: 273 SIKWLKDGVRLQTKTGV----------LHLPQAAWSDAGVYTCQAENGVGSLV 315
S+ W KD V+L T + L L A DAGVYTC A+N G ++
Sbjct: 6387 SVTWYKDSVQLVDSTRLSQQQEGTTYSLVLRHVASKDAGVYTCLAQNTGGQVL 6439
Score = 33.1 bits (74), Expect = 2.4
Identities = 36/144 (25%), Positives = 55/144 (38%), Gaps = 27/144 (18%)
Query: 681 LEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740
LE+EG + A S +++ T L T+ G L C VS + A A
Sbjct: 7436 LEKEGPPRKKPGLASFRLSGLKSWDRAPTFLRELSDETVVLGQSVTLACQVSAQPA---A 7492
Query: 741 NFSWFRNGVLWAQGPLET---------------VTLLPVARTDAALYACRILTEAGAQLS 785
+W ++G PLE+ +T+L V D +Y C + G +
Sbjct: 7493 QATWSKDGA-----PLESSSRVLISATLKNFQLLTILVVVAEDLGVYTCSVSNALGTVTT 7547
Query: 786 TPVLLSVLYPPDRPKLSALLDMGQ 809
T VL +RP S D+G+
Sbjct: 7548 T----GVLRKAERPSSSPCPDIGE 7567
>gi|98986445 carcinoembryonic antigen-related cell adhesion molecule
5 preproprotein [Homo sapiens]
Length = 702
Score = 109 bits (272), Expect = 3e-23
Identities = 150/623 (24%), Positives = 231/623 (37%), Gaps = 114/623 (18%)
Query: 335 PILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH-------SHTLRLHLATRADTGF 387
P+ + V C + D Y W+ N+ L + + TL L TR DT
Sbjct: 156 PVEDKDAVAFTCEPETQ---DATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTAS 212
Query: 388 YFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAF-LETQAGLVGILHCSVVSEPLATLVLS 446
Y CE QN + RS V + V + P P ++ ++G L C S P A
Sbjct: 213 YKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPA----- 267
Query: 447 HGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNS---LGNAT-S 502
+S +GT ++ L I ++ +SG Y C A NS L T +
Sbjct: 268 -------------QYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVT 314
Query: 503 TLDFHANAARLLISP--AAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGP---- 556
T+ +A + I+ + V + AV L+C + T + W++N L P
Sbjct: 315 TITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNT---TYLWWVNNQSLPVSPRLQL 371
Query: 557 ---GSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAG 613
+L L + + D G Y C ++ S S P +L VLY P PT + G
Sbjct: 372 SNDNRTLTLLSVTRNDVGPYECGIQNKLSVD-HSDPVILNVLYGPDDPTISPSYTYYRPG 430
Query: 614 AGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLR 673
L C S+PPA+ L + +
Sbjct: 431 VNLS----LSCHAASNPPAQYSWLIDGNI-------------------------QQHTQE 461
Query: 674 VEIHNPLLEEEGLYLCEASN-ALGNASTSA---TFNGQATVLAIAPSHT--LQEGTEANL 727
+ I N + GLY C+A+N A G++ T+ T + + +I+ +++ +++
Sbjct: 462 LFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAF 521
Query: 728 TCNVSREAAGSPANFSWFRNGVLWAQGPL-------ETVTLLPVARTDAALYACRILTEA 780
TC E + W+ NG P T+TL V R DA Y C I
Sbjct: 522 TC----EPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSV 577
Query: 781 GAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSL 840
A S PV L VLY PD P I DS L+ L H ++
Sbjct: 578 SANRSDPVTLDVLYGPDTP---------------IISPPDSSYLSGANLNLSCH---SAS 619
Query: 841 GPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV 900
P R + ++ L + ++ ++G+Y C +N+ N S+ V+ V
Sbjct: 620 NPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSI---VKSITVSA 676
Query: 901 S-PSPELQEGQAVVLSCQVHTGV 922
S SP L G V + V GV
Sbjct: 677 SGTSPGLSAGATVGIMIGVLVGV 699
Score = 105 bits (263), Expect = 3e-22
Identities = 117/448 (26%), Positives = 182/448 (40%), Gaps = 86/448 (19%)
Query: 758 TVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSAL-LDMGQGHMALFI 816
T+TL V R D A Y C A+ S V+L+VLY PD P +S L G
Sbjct: 199 TLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLS 258
Query: 817 CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRC 876
C S P A + F +G FQ + +L + + + +SGSY C
Sbjct: 259 CHAASNPPAQYSWF---------------VNGTFQQSTQ----ELFIPNITVNNSGSYTC 299
Query: 877 EATNV-LGSSNT-----SLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRW 930
+A N G + T +++ + ++ + S +++ AV L+C+ + T+Y W
Sbjct: 300 QAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEI---QNTTYLW 356
Query: 931 YRDGQPLQES-------TSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYA 983
+ + Q L S + TL ++T G Y C Q + + P+ L+V Y
Sbjct: 357 WVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQ--NKLSVDHSDPVILNVLYG 414
Query: 984 PRHVTLT-TLMDTGPGRLGLLLCRVDSDPPAQLR-LLHGDRLVASTLQGVGGPEGSSPRL 1041
P T++ + PG L C S+PPAQ L+ G+
Sbjct: 415 PDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGN-------------------- 454
Query: 1042 HVAVAPNTLRLEIHGAMLEDEGVYICEASN--------TLGQASASADFDAQAVNVQVWP 1093
+ +T L I ++ G+Y C+A+N T+ + SA+ +++
Sbjct: 455 ---IQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSN--N 509
Query: 1094 GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ-----RLDA----HSIPLPNVTVRDA 1144
V + V TC TY W+ +GQ RL ++ L NVT DA
Sbjct: 510 SKPVEDKDAVAFTC---EPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDA 566
Query: 1145 TSYRCGVGPPGRAPRLSRPITLDVLYAP 1172
+Y CG+ A R S P+TLDVLY P
Sbjct: 567 RAYVCGIQNSVSANR-SDPVTLDVLYGP 593
Score = 103 bits (258), Expect = 1e-21
Identities = 162/653 (24%), Positives = 234/653 (35%), Gaps = 119/653 (18%)
Query: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA-SNTLGQASASADF 1082
V T Q GP S + + PN L I + D G Y + L A+ F
Sbjct: 83 VIGTQQATPGPAYSGREI---IYPNASLL-IQNIIQNDTGFYTLHVIKSDLVNEEATGQF 138
Query: 1083 ----DAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQ-----RLDA-- 1131
+ ++ V + V TC T TY W+ + Q RL
Sbjct: 139 RVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQ---DATYLWWVNNQSLPVSPRLQLSN 195
Query: 1132 --HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESH-GGQL 1188
++ L NVT D SY+C P A R S + L+VLY P ++ L S+ G+
Sbjct: 196 GNRTLTLFNVTRNDTASYKCETQNPVSARR-SDSVILNVLYGPDAPTISPLNTSYRSGEN 254
Query: 1189 ALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLG 1248
+ C S PPAQ + G S+ +PN + G Y+C A +
Sbjct: 255 LNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNIT--------VNNSGSYTCQAHNSDT 306
Query: 1249 QAN----TSLELRLEGVRVILAPEAAVP--EGAPITVTCADPAAHAPTLYTWYHNGRWLQ 1302
N T++ + E + + + P + + +TC + T Y W+ N + L
Sbjct: 307 GLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQN--TTYLWWVNNQSLP 364
Query: 1303 EGPAASLS-------FLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLS-SF 1354
P LS L TR G Y C Q+ S P L VLY P D +S S+
Sbjct: 365 VSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSY 424
Query: 1355 RDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQ 1414
R + C S PPA+ + DG + H+ ++ + L
Sbjct: 425 TYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQ-----HTQELFISNITEKNSGL----- 474
Query: 1415 DVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAE---PGLD------VPEGAALNLSC 1465
Y C A N S S R V+ V AE P + V + A+ +C
Sbjct: 475 --------YTCQANN---SASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTC 523
Query: 1466 RLLGGPGPVGNSTFAWFWNDRRLHAEP-------VPTLAFTHVARAQAGMYHCLAELPTG 1518
N+T+ W+ N + L P TL +V R A Y C +
Sbjct: 524 E-----PEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVS 578
Query: 1519 AAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQP 1578
A S PV L VLY P TP + P DS L+ L+L ++ P
Sbjct: 579 ANRSDPVTLDVLYGPDTP----IISPP-----------DSSYLSGANLNLSCHSASNPSP 623
Query: 1579 Q------GAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTS 1625
Q G P + H VL I + P++ G Y C SN+ + S
Sbjct: 624 QYSWRINGIP-QQHTQVLF--------IAKITPNNNGTYACFVSNLATGRNNS 667
Score = 94.7 bits (234), Expect = 7e-19
Identities = 113/432 (26%), Positives = 173/432 (40%), Gaps = 60/432 (13%)
Query: 225 RAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ 284
R + L V Y P I SP + GE + L+C S+ PA S W +G Q
Sbjct: 224 RRSDSVILNVLYGPDAPTI--SPLNTSYRSGENLNLSCHAASNPPAQYS--WFVNGT-FQ 278
Query: 285 TKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAE-----VQVSPAGPILEN 339
T L +P +++G YTCQA N L ++ AE + + + P+ +
Sbjct: 279 QSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDE 338
Query: 340 QTVTLVCNTPNEAPSDLRYSWYKNHVLLE-------DAHSHTLRLHLATRADTGFYFCEV 392
V L C + + Y W+ N+ L + TL L TR D G Y C +
Sbjct: 339 DAVALTCEPEIQ---NTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGI 395
Query: 393 QNVHGSERSGPVSVVVNHPPLTPVLT-AFLETQAGLVGILHCSVVSEPLATLVLSHGGHI 451
QN + S PV + V + P P ++ ++ + G+ L C S P A
Sbjct: 396 QNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPA---------- 445
Query: 452 LASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSL-GNATSTLDFHANA 510
+S G ++ L I ++ E +SG Y C A NS G++ +T+ +
Sbjct: 446 --------QYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVS 497
Query: 511 ARL----LISPAAEVVEGQ-AVTLSCRSGLSPTPDARFSWYLNGALLHEGP-------GS 558
A L + S ++ VE + AV +C T + W++NG L P
Sbjct: 498 AELPKPSISSNNSKPVEDKDAVAFTCEPEAQNT---TYLWWVNGQSLPVSPRLQLSNGNR 554
Query: 559 SLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGR 618
+L L + DA +Y C ++ SA+ S P L VLY P P + +GA
Sbjct: 555 TLTLFNVTRNDARAYVCGIQNSVSAN-RSDPVTLDVLYGPDTPIISPPDSSYLSGANLN- 612
Query: 619 RGLLLCRVDSDP 630
L C S+P
Sbjct: 613 ---LSCHSASNP 621
Score = 70.5 bits (171), Expect = 1e-11
Identities = 102/419 (24%), Positives = 168/419 (40%), Gaps = 66/419 (15%)
Query: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIAS----PVELLEGTE 155
L + ++ +SGSY + S+ + T +TV EP P I S PVE +
Sbjct: 284 LFIPNITVNNSGSYTCQAHNSDTGL-NRTTVTTITVYAEPPKPFITSNNSNPVE--DEDA 340
Query: 156 VDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRI- 214
V C +Q L W S + + + TL ++++ D G
Sbjct: 341 VALTCEPE---IQNTTYLWWVNNQSLPV----SPRLQLSNDNRTLTL-LSVTRNDVGPYE 392
Query: 215 --LRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVS 272
++ +LSV + + L V Y P I SPS PG ++L+C S+ PA
Sbjct: 393 CGIQNKLSVDH---SDPVILNVLYGPDDPTI--SPSYTYYRPGVNLSLSCHAASNPPAQY 447
Query: 273 SIKWLKDGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGVG-----SLVSPPISLHIFMAE 327
S WL DG +Q T L + ++G+YTCQA N ++ + +S +
Sbjct: 448 S--WLIDG-NIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPS 504
Query: 328 VQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH-------SHTLRLHLA 380
+ + + P+ + V C + + Y W+ N L + + TL L
Sbjct: 505 ISSNNSKPVEDKDAVAFTCEPEAQ---NTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNV 561
Query: 381 TRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPL 440
TR D Y C +QN + RS PV++ V + P TP+++ P
Sbjct: 562 TRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--------------------PP 601
Query: 441 ATLVLSHGGHILASTSGDSDHSPRFS----GTSGPNSLRLEIRDLEETDSGEYKCSATN 495
+ LS G ++ S S+ SP++S G ++ L I + ++G Y C +N
Sbjct: 602 DSSYLS-GANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSN 659
Score = 52.8 bits (125), Expect = 3e-06
Identities = 113/538 (21%), Positives = 194/538 (36%), Gaps = 82/538 (15%)
Query: 660 SPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG-NASTSATFNGQ--ATVLAIAPS 716
SPR++++ L + N + Y CE N + S S N I+P
Sbjct: 188 SPRLQLSNGNRTLT--LFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPL 245
Query: 717 HT-LQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACR 775
+T + G NL+C+ A+ PA +SWF NG Q + + + + ++ Y C+
Sbjct: 246 NTSYRSGENLNLSCHA---ASNPPAQYSWFVNGTF--QQSTQELFIPNITVNNSGSYTCQ 300
Query: 776 I-LTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEH 834
++ G +T ++V P +P FI + +S P+ E
Sbjct: 301 AHNSDTGLNRTTVTTITVYAEPPKP---------------FITSNNSNPV------EDED 339
Query: 835 LLATSLGPQV--------------PSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATN 880
+A + P++ P R Q + +L L + D G Y C N
Sbjct: 340 AVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTL--LSVTRNDVGPYECGIQN 397
Query: 881 VLGSSNTS-LFFQVRGAWVQVSPSPE---LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQP 936
L ++ + V + SP + G + LSC + P Y W DG
Sbjct: 398 KLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPP--AQYSWLIDGN- 454
Query: 937 LQESTSATLRFAAITLTQAGAYHCQA--QAPGSATTSLAAPISLHVSYAPRHVTLTTLMD 994
+Q+ T L + IT +G Y CQA A G + T++ I++ ++
Sbjct: 455 IQQHTQ-ELFISNITEKNSGLYTCQANNSASGHSRTTVKT-ITVSAELPKPSISSNNSKP 512
Query: 995 TGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEI 1054
C ++ L ++G L SPRL ++ TL L
Sbjct: 513 VEDKDAVAFTCEPEAQNTTYLWWVNGQSLPV------------SPRLQLSNGNRTLTL-- 558
Query: 1055 HGAMLEDEGVYICEASNTL-GQASASADFD---AQAVNVQVWPGATVREGQLVNLTCLVW 1110
D Y+C N++ S D + P ++ G +NL+C
Sbjct: 559 FNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSA 618
Query: 1111 TTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVG--PPGRAPRLSRPITL 1166
+ Q Y+W +G + + + +T + +Y C V GR + + IT+
Sbjct: 619 SNPSPQ--YSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITV 674
>gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Homo
sapiens]
Length = 698
Score = 108 bits (269), Expect = 6e-23
Identities = 135/531 (25%), Positives = 217/531 (40%), Gaps = 80/531 (15%)
Query: 5 PKLLLLASFFPAGQA-------SWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITA 57
P++LLL P A S+ + + V +G C+++ C S+P D D TA
Sbjct: 11 PEMLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDGW--DESTA 68
Query: 58 IWYYDYSGQRQV-----VSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGS 112
+ Y + G+ V+ + + VE R R + G+P C+L+++D Q ED
Sbjct: 69 AYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAW 128
Query: 113 YNFRFEISEVNRWSDVKGT-LVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQV 171
Y FR E R S + + VT + P + P L G V C
Sbjct: 129 YFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTVICV---------- 178
Query: 172 RLQWQGQD-PARSVTFNSQKFEP----TGVGHLETLHMAMSWQDHGRILRCQLSVANH-- 224
W + PA S ++ P H L S QDH L C + +
Sbjct: 179 -FNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGV 237
Query: 225 RAQSEIHLQVKYAPKGVKILLSPSGRNIL------------PGELVTLTCQVNSSYPAVS 272
AQ + L+V YAPK + I +S + L G+ + L C +S PA
Sbjct: 238 SAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPA-- 295
Query: 273 SIKW-LKDGVRLQT-----KTGVLHLPQAAWSDAGVYTCQAENGVG--------SLVSPP 318
++ W L+D V + +T L L D+G YTC+AEN +G S+ PP
Sbjct: 296 TLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPP 355
Query: 319 ISLHIFMAEVQVS--------PAGPILENQTVTLVCNTPNEAPSDLRYS-WYKNHVLLED 369
+L + +++ + + P+LE Q++ LVC T + P+ L ++ W + +
Sbjct: 356 ENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQP 415
Query: 370 AHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVG 429
+ L L G + C Q+ GS+ +S+ V++PP + E +
Sbjct: 416 SDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVS-LSLSVHYPPQLLGPSCSWEAEG---- 470
Query: 430 ILHCSVVSE--PLATLVLSHGGHILA--STSGDSDHSPRFSGTSGPNSLRL 476
LHCS S+ P +L G +L S+ G + +P +G +SL L
Sbjct: 471 -LHCSCSSQASPAPSLRWWLGEELLEGNSSQGSFEVTPSSAGPWANSSLSL 520
Score = 70.1 bits (170), Expect = 2e-11
Identities = 66/238 (27%), Positives = 99/238 (41%), Gaps = 38/238 (15%)
Query: 1145 TSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY---------------LLESHGGQLA 1189
T C V + R + L V YAP++L ++ LE GQ
Sbjct: 224 TDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFL 283
Query: 1190 LVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQ 1249
+LC DS+PPA L+ R+L+SS P TL LELRG + D G Y+C A + LG
Sbjct: 284 RLLCAADSQPPATLSWVLQDRVLSSSHPWG-PRTLGLELRGVRAGDSGRYTCRAENRLGS 342
Query: 1250 ANTSLELRL----EGVRVILA-------------PEAAVPEGAPITVTCADPAAHAPTLY 1292
+L+L + E +RV+++ V EG + + C ++ P
Sbjct: 343 QQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSS-PPARL 401
Query: 1293 TWYHNGRWL---QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQ 1347
+W G+ + Q L H G ++C AQ G++ +L V Y PQ
Sbjct: 402 SWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHV-SLSLSVHYPPQ 458
Score = 68.6 bits (166), Expect = 5e-11
Identities = 111/480 (23%), Positives = 181/480 (37%), Gaps = 81/480 (16%)
Query: 843 QVPSHGRFQAKAEAN--SLKLEVRELGLGDSGSY--RCEATNVLGSSNTSLFFQVRGAWV 898
++ + RFQ + S L +R+ D Y R E + + S S F ++ +
Sbjct: 96 EMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTAL 155
Query: 899 QVSPS---PE-LQEGQAVVLSCQVHTGVPE--GTSYRWYRDGQPLQESTSATLRFAAITL 952
P PE L+ GQ V + C + + S+ W + + +T F+ ++
Sbjct: 156 TKKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSF 215
Query: 953 TQAGAYH-----CQAQAPGSATTSLAAPISLHVSYAPRHVTLTT---------------L 992
T + H C S + L V+YAP+ + ++
Sbjct: 216 TPSPQDHDTDLTCHVDFSRKGV-SAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIY 274
Query: 993 MDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRL 1052
++ G+ LLC DS PPA L + DR+++S+ P G P TL L
Sbjct: 275 LEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSS-----HPWG----------PRTLGL 319
Query: 1053 EIHGAMLEDEGVYICEASNTLGQASASADFDAQ-----------------AVNVQVWPGA 1095
E+ G D G Y C A N LG + D Q N+
Sbjct: 320 ELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSL 379
Query: 1096 TVREGQLVNLTCLVWTTHPAQLTYT-WYQ--DGQQRLDAHSIPLPNVTVRDATSYRCGVG 1152
V EGQ + L C+ ++ PA+L++T W Q Q D + LP + + + C
Sbjct: 380 PVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQ 439
Query: 1153 PPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLL 1212
P + +S ++L V Y P+ L + E+ G + C+ + P L LL
Sbjct: 440 HPLGSQHVS--LSLSVHYPPQLLGPSCSWEAEGLHCS---CSSQASPAPSLRWWLGEELL 494
Query: 1213 -ASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAV 1271
+S+ S T P G ++ S+ S G ++ L LR + V A +V
Sbjct: 495 EGNSSQGSFEVT---------PSSAGPWANSSLSLHGGLSSGLRLRCKAWNVHGAQSGSV 545
Score = 67.0 bits (162), Expect = 1e-10
Identities = 106/409 (25%), Positives = 153/409 (37%), Gaps = 75/409 (18%)
Query: 1226 LELRGPQPRDEG--FYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE----GAPITV 1279
L +R Q DE F+ S + + S L+ + P+ +PE G P+TV
Sbjct: 116 LVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTV 175
Query: 1280 TC----ADPAAHAPTLYTWYHNGRWL---QEGPAAS----LSFLVATRAHAGAYSCQAQ- 1327
C A AP+ ++W G L + P+ S LSF + + H +C
Sbjct: 176 ICVFNWAFKKCPAPS-FSW--TGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDF 232
Query: 1328 DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR---------------SMAVIQCTVDSE 1372
+G + R L+V YAP+D ++S D+ + + C DS+
Sbjct: 233 SRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQ 292
Query: 1373 PPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLL 1431
PPA L+ +VL++S H T L L+++ V AGD Y C A+N L
Sbjct: 293 PPATLSWVLQDRVLSSS---HPWGPRT---------LGLELRGVRAGDSGRYTCRAENRL 340
Query: 1432 GSISTIGRLQV----EGARVVAE-------------PGLDVPEGAALNLSCRLLGGPGPV 1474
GS L V E RV+ L V EG +L L C P P
Sbjct: 341 GSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSP-PA 399
Query: 1475 GNSTFAWFWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPK 1534
S W L + G + C A+ P G + + L V YPP+
Sbjct: 400 RLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLG-SQHVSLSLSVHYPPQ 458
Query: 1535 TPTMMVFVEPEGGLRGILDCRVDSE--PLASLTLHLGSRLVASSQPQGA 1581
E EG L C S+ P SL LG L+ + QG+
Sbjct: 459 LLGPSCSWEAEG-----LHCSCSSQASPAPSLRWWLGEELLEGNSSQGS 502
Score = 65.5 bits (158), Expect = 4e-10
Identities = 126/517 (24%), Positives = 181/517 (35%), Gaps = 109/517 (21%)
Query: 464 RFSGTSGPNSLRLEIRDLEETDSGEY--KCSATNSLGNATSTLDFHANAARLLISPAAEV 521
+ +G G S L IRD + D Y + + + ++ + F L P +
Sbjct: 104 QLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYI 163
Query: 522 VE----GQAVTLSC--RSGLSPTPDARFSWYLNGALL----------HEGPGSSLLLPAA 565
E GQ VT+ C P FSW GA L H S P
Sbjct: 164 PETLEPGQPVTVICVFNWAFKKCPAPSFSW--TGAALSPRRTRPSTSHFSVLSFTPSPQD 221
Query: 566 SSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAA----------GAG 615
TD + +R G SA L V Y P+ + D +A
Sbjct: 222 HDTDLTCHVDFSRKGVSAQ---RTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQ 278
Query: 616 AGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVE 675
G+ LLC DS PPA L + +DRV+++S P G P L +E
Sbjct: 279 KGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWG------------------PRTLGLE 320
Query: 676 IHNPLLEEEGLYLCEASNALGNASTSATFNGQ--------------ATVLAIAPSHT--- 718
+ + G Y C A N LG+ + + Q TVL + T
Sbjct: 321 LRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLP 380
Query: 719 LQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQ--GPLE-----TVTLLPVARTDAAL 771
+ EG L C + PA SW R W Q GP + + L P+
Sbjct: 381 VLEGQSLRLVCVTH---SSPPARLSWTR----WGQTVGPSQPSDPGVLELPPIQMEHEGE 433
Query: 772 YACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFH 831
+ C G+Q + LSV YPP S + H + C+ + P L +
Sbjct: 434 FTCHAQHPLGSQ-HVSLSLSVHYPPQLLGPSCSWEAEGLHCS---CSSQASPAPSLRWWL 489
Query: 832 GEHLLATSLGPQVPSHGRFQAKAEA------NSLKLEVRELGLGDSGSYRCEATNVLGSS 885
GE LL + S G F+ + +SL L GL RC+A NV G+
Sbjct: 490 GEELLEGN-----SSQGSFEVTPSSAGPWANSSLSLHG---GLSSGLRLRCKAWNVHGAQ 541
Query: 886 NTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGV 922
+ S+F + G +L+ G + L + GV
Sbjct: 542 SGSVFQLLPG---------KLEHGGGLGLGAALGAGV 569
Score = 61.6 bits (148), Expect = 6e-09
Identities = 60/200 (30%), Positives = 82/200 (41%), Gaps = 35/200 (17%)
Query: 420 FLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIR 479
+LE Q G L C+ S+P ATL +L+S S GP +L LE+R
Sbjct: 274 YLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSS-----------SHPWGPRTLGLELR 322
Query: 480 DLEETDSGEYKCSATNSLGNATSTLD----FHANAARLLISPA-------------AEVV 522
+ DSG Y C A N LG+ LD + R+++S A V+
Sbjct: 323 GVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVL 382
Query: 523 EGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSS---LLLPAASSTDAGSYHCRARD 579
EGQ++ L C + S P AR SW G + S L LP G + C A+
Sbjct: 383 EGQSLRLVCVTHSS--PPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQ- 439
Query: 580 GHSASGPSSPAVLTVLYPPR 599
H L+V YPP+
Sbjct: 440 -HPLGSQHVSLSLSVHYPPQ 458
Score = 50.1 bits (118), Expect = 2e-05
Identities = 36/119 (30%), Positives = 53/119 (44%), Gaps = 27/119 (22%)
Query: 1518 GAAASAPVMLRVLYPPKTPTM---------------MVFVEPEGGLRGILDCRVDSEPLA 1562
G +A V LRV Y PK + ++++E + G L C DS+P A
Sbjct: 236 GVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPA 295
Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621
+L+ L R+++SS P G P L +++ +R D G Y C A N LGS
Sbjct: 296 TLSWVLQDRVLSSSHPWG------------PRTLGLELRGVRAGDSGRYTCRAENRLGS 342
Score = 38.1 bits (87), Expect = 0.074
Identities = 50/198 (25%), Positives = 71/198 (35%), Gaps = 39/198 (19%)
Query: 1453 LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP-----VPTLAFTHVARAQAG 1507
L+V +G L L C P +T +W DR L + L V +G
Sbjct: 275 LEVQKGQFLRLLCAADSQPP----ATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSG 330
Query: 1508 MYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI---------------L 1552
Y C AE G+ A + L V YPP+ +MV L + L
Sbjct: 331 RYTCRAENRLGSQQQA-LDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRL 389
Query: 1553 DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612
C S P A L+ + V SQP + P L ++ ++ +GE+
Sbjct: 390 VCVTHSSPPARLSWTRWGQTVGPSQP------------SDPGVL--ELPPIQMEHEGEFT 435
Query: 1613 CSASNVLGSASTSTYFGV 1630
C A + LGS S V
Sbjct: 436 CHAQHPLGSQHVSLSLSV 453
>gi|31377639 sialic acid binding Ig-like lectin 10 [Homo sapiens]
Length = 697
Score = 108 bits (269), Expect = 6e-23
Identities = 131/524 (25%), Positives = 215/524 (41%), Gaps = 74/524 (14%)
Query: 8 LLLASFFPAGQASWG---VSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYS 64
LLL+S QA G + + V +G C+ +PC FS+P G T + Y +
Sbjct: 5 LLLSSLLGGSQAMDGRFWIRVQESVMVPEGLCISVPCSFSYPRQDWT--GSTPAYGYWFK 62
Query: 65 GQRQV-----VSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEI 119
+ V+ + + VE RGR + G+P C+L+++D Q +D Y FR E
Sbjct: 63 AVTETTKGAPVATNHQSREVEMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFRVER 122
Query: 120 SEVNRWSDVK-GTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQ-EQVRLQWQG 177
R++ + G + VT + P + P L G V C + + W G
Sbjct: 123 GSYVRYNFMNDGFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSWTG 182
Query: 178 QDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANH--RAQSEIHLQVK 235
+SQ +PT H L QDH L C + + AQ + L+V
Sbjct: 183 ------AALSSQGTKPT-TSHFSVLSFTPRPQDHNTDLTCHVDFSRKGVSAQRTVRLRVA 235
Query: 236 YAPKGVKILLS--------PSGRNILP------GELVTLTCQVNSSYPAVSSIKWLKDGV 281
YAP+ + I +S P + +P G+ + L C +S PA ++ W+
Sbjct: 236 YAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQPPA--TLSWVLQNR 293
Query: 282 RLQT------KTGVLHLPQAAWSDAGVYTCQAENGVG--------SLVSPPISLHIFMAE 327
L + + L LP D+G YTC+AEN +G S+ PP +L + +++
Sbjct: 294 VLSSSHPWGPRPLGLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQ 353
Query: 328 VQVS--------PAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLL---EDAHSHTLR 376
+ + P+LE Q++ LVC T + P+ R SW + +L + + L
Sbjct: 354 ANRTVLENLGNGTSLPVLEGQSLCLVCVTHSSPPA--RLSWTQRGQVLSPSQPSDPGVLE 411
Query: 377 LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVV 436
L G + C ++ GS+ +S+ V++ P + E + LHCS
Sbjct: 412 LPRVQVEHEGEFTCHARHPLGSQHVS-LSLSVHYSPKLLGPSCSWEAEG-----LHCSCS 465
Query: 437 SE--PLATLVLSHGGHILASTSGDS--DHSPRFSGTSGPNSLRL 476
S+ P +L G +L S + +P +G +SL L
Sbjct: 466 SQASPAPSLRWWLGEELLEGNSSQDSFEVTPSSAGPWANSSLSL 509
Score = 80.5 bits (197), Expect = 1e-14
Identities = 77/265 (29%), Positives = 116/265 (43%), Gaps = 33/265 (12%)
Query: 1093 PGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH-------SIPLPNVTVRDAT 1145
P ++GQ + L C + PA T +W + +H + LP V D+
Sbjct: 262 PYLEAQKGQFLRLLCAADSQPPA--TLSWVLQNRVLSSSHPWGPRPLGLELPGVKAGDSG 319
Query: 1146 SYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY------LLESHG---------GQLAL 1190
Y C R R + L V Y P NLR+ +LE+ G GQ
Sbjct: 320 RYTCRA--ENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLC 377
Query: 1191 VLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQA 1250
++C S PPA+L+ + G++L+ S + P L EL Q EG ++C AR PLG
Sbjct: 378 LVCVTHSSPPARLSWTQRGQVLSPSQPSD-PGVL--ELPRVQVEHEGEFTCHARHPLGSQ 434
Query: 1251 NTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLS 1310
+ SL L + +L P + E + +C+ A+ AP+L W G L EG ++ S
Sbjct: 435 HVSLSLSVHYSPKLLGPSCSW-EAEGLHCSCSSQASPAPSLRWWL--GEELLEGNSSQDS 491
Query: 1311 FLVATRAHAGAYSCQAQDAQGTRSS 1335
F V T + AG ++ + G SS
Sbjct: 492 FEV-TPSSAGPWANSSLSLHGGLSS 515
Score = 73.2 bits (178), Expect = 2e-12
Identities = 111/475 (23%), Positives = 176/475 (37%), Gaps = 85/475 (17%)
Query: 843 QVPSHGRFQAKAEA--NSLKLEVRELGLGDSGSY--RCEATNVLGSSNTSLFFQVRGAWV 898
++ + GRFQ + + L +R+ + D Y R E + + + + F ++ +
Sbjct: 83 EMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFRVERGSYVRYNFMNDGFFLKVTAL 142
Query: 899 QVSPS---PE-LQEGQAVVLSCQVHTGVPE--GTSYRWYRDGQPLQESTSATLRFAAITL 952
P PE L+ GQ V + C + E S+ W Q + T F+ ++
Sbjct: 143 TQKPDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSWTGAALSSQGTKPTTSHFSVLSF 202
Query: 953 TQAGAYH-----CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGP---------- 997
T H C S + L V+YAPR + ++ D P
Sbjct: 203 TPRPQDHNTDLTCHVDFSRKGV-SAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNV 261
Query: 998 -------GRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTL 1050
G+ LLC DS PPA L + +R+++S+ P G P L
Sbjct: 262 PYLEAQKGQFLRLLCAADSQPPATLSWVLQNRVLSSS-----HPWG----------PRPL 306
Query: 1051 RLEIHGAMLEDEGVYICEASNTLGQASASADFDAQ-----------------AVNVQVWP 1093
LE+ G D G Y C A N LG + D Q N+
Sbjct: 307 GLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGT 366
Query: 1094 GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQ-----QRLDAHSIPLPNVTVRDATSYR 1148
V EGQ + L C+ ++ PA+L +W Q GQ Q D + LP V V +
Sbjct: 367 SLPVLEGQSLCLVCVTHSSPPARL--SWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFT 424
Query: 1149 CGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHA 1208
C P + +S ++L V Y+P+ L + E+ G + C+ + P L
Sbjct: 425 CHARHPLGSQHVS--LSLSVHYSPKLLGPSCSWEAEGLHCS---CSSQASPAPSLRWWLG 479
Query: 1209 GRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRV 1263
LL +++ P G ++ S+ S G ++ L LR E V
Sbjct: 480 EELLEGNSSQDSFEV--------TPSSAGPWANSSLSLHGGLSSGLRLRCEAWNV 526
Score = 68.6 bits (166), Expect = 5e-11
Identities = 64/240 (26%), Positives = 100/240 (41%), Gaps = 40/240 (16%)
Query: 1145 TSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY-----------------LLESHGGQ 1187
T C V + R + L V YAPR+L ++ LE+ GQ
Sbjct: 211 TDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQ 270
Query: 1188 LALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPL 1247
+LC DS+PPA L+ R+L+SS P L LEL G + D G Y+C A + L
Sbjct: 271 FLRLLCAADSQPPATLSWVLQNRVLSSSHPWG-PRPLGLELPGVKAGDSGRYTCRAENRL 329
Query: 1248 GQANTSLELRL----EGVRVILA-------------PEAAVPEGAPITVTCADPAAHAPT 1290
G +L+L + E +RV+++ V EG + + C ++ P
Sbjct: 330 GSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLCLVCVTHSS-PPA 388
Query: 1291 LYTWYHNGRWLQEGPAASLSFLVATRA---HAGAYSCQAQDAQGTRSSRPAALQVLYAPQ 1347
+W G+ L + L R H G ++C A+ G++ +L V Y+P+
Sbjct: 389 RLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCHARHPLGSQHV-SLSLSVHYSPK 447
Score = 61.2 bits (147), Expect = 8e-09
Identities = 60/200 (30%), Positives = 81/200 (40%), Gaps = 35/200 (17%)
Query: 420 FLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIR 479
+LE Q G L C+ S+P ATL +L+S S GP L LE+
Sbjct: 263 YLEAQKGQFLRLLCAADSQPPATLSWVLQNRVLSS-----------SHPWGPRPLGLELP 311
Query: 480 DLEETDSGEYKCSATNSLGNATSTLD----FHANAARLLISPA-------------AEVV 522
++ DSG Y C A N LG+ LD + R+++S A V+
Sbjct: 312 GVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVL 371
Query: 523 EGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSS---LLLPAASSTDAGSYHCRARD 579
EGQ++ L C + S P AR SW G +L S L LP G + C AR
Sbjct: 372 EGQSLCLVCVTHSS--PPARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCHAR- 428
Query: 580 GHSASGPSSPAVLTVLYPPR 599
H L+V Y P+
Sbjct: 429 -HPLGSQHVSLSLSVHYSPK 447
Score = 57.4 bits (137), Expect = 1e-07
Identities = 96/366 (26%), Positives = 131/366 (35%), Gaps = 75/366 (20%)
Query: 1267 PEAAVPE----GAPITVTCADPAAHA---PTLYTWYHNGRWLQ-EGPAAS----LSFLVA 1314
P+ +PE G P+TV C A P ++W Q P S LSF
Sbjct: 146 PDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSWTGAALSSQGTKPTTSHFSVLSFTPR 205
Query: 1315 TRAHAGAYSCQAQ-DAQGTRSSRPAALQVLYAPQDAVLSSFRD----------------- 1356
+ H +C +G + R L+V YAP+D V+S RD
Sbjct: 206 PQDHNTDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLE 265
Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416
++ + C DS+PPA L+ +VL++S H R L L++ V
Sbjct: 266 AQKGQFLRLLCAADSQPPATLSWVLQNRVLSSS-----------HPWGPR-PLGLELPGV 313
Query: 1417 PAGDD-TYVCTAQNLLGSISTIGRLQV----EGARVVAE-------------PGLDVPEG 1458
AGD Y C A+N LGS L V E RV+ L V EG
Sbjct: 314 KAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEG 373
Query: 1459 AALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQA---GMYHCLAEL 1515
+L L C P + +W + L + R Q G + C A
Sbjct: 374 QSLCLVCVTHSSP----PARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCHARH 429
Query: 1516 PTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSE--PLASLTLHLGSRLV 1573
P G + + L V Y PK E EG L C S+ P SL LG L+
Sbjct: 430 PLG-SQHVSLSLSVHYSPKLLGPSCSWEAEG-----LHCSCSSQASPAPSLRWWLGEELL 483
Query: 1574 ASSQPQ 1579
+ Q
Sbjct: 484 EGNSSQ 489
Score = 53.9 bits (128), Expect = 1e-06
Identities = 117/475 (24%), Positives = 163/475 (34%), Gaps = 80/475 (16%)
Query: 464 RFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD--FHANAARLLISPAAEV 521
+ +G + L IRD + D +Y + ++ F L P +
Sbjct: 91 QLTGDPAKGNCSLVIRDAQMQDESQYFFRVERGSYVRYNFMNDGFFLKVTALTQKPDVYI 150
Query: 522 VE----GQAVTLSC--RSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHC 575
E GQ VT+ C P FSW GA L S P S S+
Sbjct: 151 PETLEPGQPVTVICVFNWAFEECPPPSFSW--TGAAL----SSQGTKPTTSHFSVLSFTP 204
Query: 576 RARDGH---------SASGPSSPAV--LTVLYPPRQPTFTTRLDLDAA------------ 612
R +D + S G S+ L V Y PR + D A
Sbjct: 205 RPQDHNTDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYL 264
Query: 613 GAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLL 672
A G+ LLC DS PPA L + ++RV+++S P G P L
Sbjct: 265 EAQKGQFLRLLCAADSQPPATLSWVLQNRVLSSSHPWG------------------PRPL 306
Query: 673 RVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQ--------------ATVLAIAPSHT 718
+E+ + G Y C A N LG+ + + Q TVL + T
Sbjct: 307 GLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGT 366
Query: 719 LQEGTEANLTCNVSREAAGSPANFSWFRNG-VLWAQGPLETVTL-LPVARTD-AALYACR 775
E C V + PA SW + G VL P + L LP + + + C
Sbjct: 367 SLPVLEGQSLCLVCVTHSSPPARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCH 426
Query: 776 ILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHL 835
G+Q + LSV Y P S + H + C+ + P L + GE L
Sbjct: 427 ARHPLGSQ-HVSLSLSVHYSPKLLGPSCSWEAEGLHCS---CSSQASPAPSLRWWLGEEL 482
Query: 836 LATSLGPQVPSHGRFQAKAEAN-SLKLEVRELGLGDSGSYRCEATNVLGSSNTSL 889
L + A AN SL L GL RCEA NV G+ + S+
Sbjct: 483 LEGNSSQDSFEVTPSSAGPWANSSLSLHG---GLSSGLRLRCEAWNVHGAQSGSI 534
Score = 47.8 bits (112), Expect = 9e-05
Identities = 36/121 (29%), Positives = 55/121 (45%), Gaps = 29/121 (23%)
Query: 1518 GAAASAPVMLRVLYPPK----------TPTM-------MVFVEPEGGLRGILDCRVDSEP 1560
G +A V LRV Y P+ TP + + ++E + G L C DS+P
Sbjct: 223 GVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQP 282
Query: 1561 LASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLG 1620
A+L+ L +R+++SS P G P L +++ ++ D G Y C A N LG
Sbjct: 283 PATLSWVLQNRVLSSSHPWG------------PRPLGLELPGVKAGDSGRYTCRAENRLG 330
Query: 1621 S 1621
S
Sbjct: 331 S 331
Score = 37.7 bits (86), Expect = 0.096
Identities = 53/200 (26%), Positives = 77/200 (38%), Gaps = 39/200 (19%)
Query: 1451 PGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAE----PVPT-LAFTHVARAQ 1505
P L+ +G L L C P +T +W +R L + P P L V
Sbjct: 262 PYLEAQKGQFLRLLCAADSQPP----ATLSWVLQNRVLSSSHPWGPRPLGLELPGVKAGD 317
Query: 1506 AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI-------------- 1551
+G Y C AE G+ A + L V YPP+ +MV L +
Sbjct: 318 SGRYTCRAENRLGSQQRA-LDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSL 376
Query: 1552 -LDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGE 1610
L C S P A L+ ++++ SQP ++P + L RV +E +GE
Sbjct: 377 CLVCVTHSSPPARLSWTQRGQVLSPSQP----SDPGVLELP-----RVQVE-----HEGE 422
Query: 1611 YICSASNVLGSASTSTYFGV 1630
+ C A + LGS S V
Sbjct: 423 FTCHARHPLGSQHVSLSLSV 442
>gi|144226847 obscurin-like 1 [Homo sapiens]
Length = 1896
Score = 106 bits (265), Expect = 2e-22
Identities = 323/1368 (23%), Positives = 470/1368 (34%), Gaps = 256/1368 (18%)
Query: 190 KFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSG 249
+ E G+ H LH A+ QD G ++ + Q L ++ +P + LSP
Sbjct: 671 RIEQKGLQHRLILH-AVKHQDSGALV----GFSCPGVQDSAALTIQESPVHI---LSPQD 722
Query: 250 RNILP---GELVTLTCQVNS-SYPAVSSIKWLKDG----------VRLQTKTGVLHLPQA 295
R L E V LTC+++ +PA W KDG V++ + L LP+A
Sbjct: 723 RVSLTFTTSERVVLTCELSRVDFPAT----WYKDGQKVEESELLVVKMDGRKHRLILPEA 778
Query: 296 AWSDAGVYTCQAEN-----GVGSLVSPPISL-----HIFMAEVQVSPAGPILENQTVTLV 345
D+G + C+ E GV ++ PP+ + H+F+ + ++ V L
Sbjct: 779 KVQDSGEFECRTEGVSAFFGV-TVQDPPVHIVDPREHVFVHAI---------TSECVMLA 828
Query: 346 CNTPNEAPSDLRYSWYK--------NHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHG 397
C E D WYK + V+LE+ H + AT+ G E Q V G
Sbjct: 829 CEVDRE---DAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDG---GEFQCVAG 882
Query: 398 SERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSG 457
E + + + +++++ +G V + + L + + + G
Sbjct: 883 DECAYFTVTITD-------VSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDG 935
Query: 458 DS-DHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLIS 516
+ SP RL + ++ DSGEY C + + T T+ +I
Sbjct: 936 EEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTV---TEPPVRIIY 992
Query: 517 PAAEVVEGQAVTLSCRSGLS--PTPDARFSWYLNG---------ALLHEGPGSSLLLPAA 565
P EV AVTL C + DA WY +G L +GP L+LPAA
Sbjct: 993 PRDEVTL-IAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAA 1051
Query: 566 SSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCR 625
D G + C A D S+ +TV PP + LD GR L R
Sbjct: 1052 QPEDGGEFVCDAGD------DSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVEL---R 1102
Query: 626 VDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685
+ P +KD + G P +T + + E+ G
Sbjct: 1103 CEVAPAGSQVRWYKDGLEV----EASDALQLGAEGPTRTLT---------LPHAQPEDAG 1149
Query: 686 LYLCEASNALGNASTSATFN-------GQATVLAIAPSH-TLQEGTEANLTCNVSREAAG 737
Y+CE + + TFN Q L PS + G L+C +SR AG
Sbjct: 1150 EYVCETRH------EAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSR--AG 1201
Query: 738 SPANFSWFRNG---------VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPV 788
+P W NG L A+GP + + A LY C ++GA P
Sbjct: 1202 APV--VWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTC----QSGAAPGAPS 1255
Query: 789 LLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALF-----HGEHLLATSLGPQ 843
L + + P + Q V S P L L G + G +
Sbjct: 1256 LSFTVQVAEPPVRVVAPEAAQ-------TRVRSTPGGDLELVVHLSGPGGPVRWYKDGER 1308
Query: 844 VPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPS 903
+ S GR Q + L V+ GD+G Y C+A S+ + V
Sbjct: 1309 LASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTP 1368
Query: 904 PELQEGQAVVLSCQVHTGVPEGTSYRWYRDG---------QPLQESTSATLRFAAITLTQ 954
+ EG C+V P W R+G + Q +S L L
Sbjct: 1369 LTVHEGDDATFRCEVS---PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGD 1425
Query: 955 AGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQ 1014
AG +A GS TS LHV + L L D R +
Sbjct: 1426 AGTVTLRA---GSTATS----ARLHVR-ETELLFLRRLQDV----------RAEEGQDVC 1467
Query: 1015 LRLLHGDRLVASTLQGV--GGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA--S 1070
L + G A ++ V G P RL +A + RL IHG +L D+G Y CE+
Sbjct: 1468 LEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHD 1527
Query: 1071 NTLGQASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLD 1130
TL + S Q ++ T+ EG +T W + G Q
Sbjct: 1528 RTLARLSVR---PRQLRVLRPLEDVTISEGGSATFQL---ELSQEGVTGEWARGGVQLYP 1581
Query: 1131 A-----------HSIPLPNVTVRD-------ATSYRCGVGPPGRAPRLSRPITLDVLYAP 1172
H + L + + D A S RC A + R + + ++ P
Sbjct: 1582 GPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCA------ARLIVREVPVTIVRGP 1635
Query: 1173 RNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVP--NTLR-LELR 1229
+L +T G A C + S+ A + G L S + T R L+LR
Sbjct: 1636 HDLEVT------EGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLR 1688
Query: 1230 GPQPRDEGFYSCS-ARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHA 1288
P D G YSC+ + G ++ R V L +A EG T C +
Sbjct: 1689 RCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSA-REGDGATFECT--VSEV 1745
Query: 1289 PTLYTWYHNGRWL---------QEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAA 1339
T W GR L QEG L AG QA AQ A
Sbjct: 1746 ETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSL-----AL 1800
Query: 1340 LQVLYAPQDAVLSSFRDSR--ARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLAS 1397
L+V P R+ AV++ TV S + +G L +
Sbjct: 1801 LEVEALPLQMCRHPPREKTVLVGRRAVLEVTV-SRSGGHVCWLREGAELCPGDKYEMRSH 1859
Query: 1398 GTGHVQVARNALRLQVQDV-PAGDDTYVCTAQNLLGSISTIGRLQVEG 1444
G H L + DV P TY C A G ST RL VEG
Sbjct: 1860 GPTH--------SLVIHDVRPEDQGTYCCQA----GQDSTHTRLLVEG 1895
Score = 89.7 bits (221), Expect = 2e-17
Identities = 290/1335 (21%), Positives = 442/1335 (33%), Gaps = 273/1335 (20%)
Query: 244 LLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRL--------------QTKTG- 288
L P + +L G V LTC+ ++ W KDG+ L + + G
Sbjct: 131 LTGPRSQWVLRGAEVVLTCRAGGL--PEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP 188
Query: 289 ----VLHLPQAAWSDAGVYTCQAENGVG--------SLVSPPISLHIFMAEVQVSPAGPI 336
L + A D+GVY C A N G + PP S E P+
Sbjct: 189 GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248
Query: 337 L---------ENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH---------SHTLRLH 378
E + C + ++ + W + LL D L++
Sbjct: 249 KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHW-EGRPLLPDRRRLMYRDRDGGFVLKVL 307
Query: 379 LATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGL---VGILHCSV 435
D G Y C +N G S V + V P L T L+ G + +L C V
Sbjct: 308 YCQAKDRGLYVCAARNSAGQTLSA-VQLHVKEPRLR--FTRPLQDVEGREHGIAVLECKV 364
Query: 436 VSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSA-- 493
+ + T +L ++ RL I L+ D G Y C
Sbjct: 365 PNSRIPTAWFREDQRLLPCR--------KYEQIEEGTVRRLIIHRLKADDDGIYLCEMRG 416
Query: 494 -TNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALL 552
++ N T R L +V+EG+ L + L + R W +G L
Sbjct: 417 RVRTVANVTVKGPILKRLPRKL-----DVLEGENAVLLVET-LEAGVEGR--WSRDGEEL 468
Query: 553 ------HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTR 606
G +L+LP + DAG G+S + PP P
Sbjct: 469 PVICQSSSGHMHALVLPGVTREDAGEVTFSL--GNSRTTTLLRVKCVKHSPPGPPILAEM 526
Query: 607 LDLDAAGAGAGRRGLLLCRVDSDPPA----------RLQLLHKDRVVATSLPSGGGCSTC 656
G + +L PA R ++ +D + S+ G
Sbjct: 527 FK--------GHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVP 578
Query: 657 GGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNA-STSATFNGQA----TVL 711
G C P EG Y G+ S F+G A T
Sbjct: 579 GDCVP---------------------SEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTAR 617
Query: 712 AIAPSHTLQ--EGTEANLTCNVSREAAGSPANFSWFRNGV-------------------L 750
+A +Q +G +A + ++S G+ WF NG +
Sbjct: 618 LVAGLEDVQVYDGEDAVFSLDLSTIIQGT-----WFLNGEELKSNEPEGQVEPGALRYRI 672
Query: 751 WAQGPLETVTLLPVARTDAAL---YACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDM 807
+G + L V D+ ++C + ++ A + +L P DR L+
Sbjct: 673 EQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTS- 731
Query: 808 GQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELG 867
+ T + + A ++ + G +V K + +L + E
Sbjct: 732 -----ERVVLTCELSRVDFPATWYKD-------GQKVEESELLVVKMDGRKHRLILPEAK 779
Query: 868 LGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQE----------GQAVVLSCQ 917
+ DSG + C V S FF G VQ P + + V+L+C+
Sbjct: 780 VQDSGEFECRTEGV------SAFF---GVTVQDPPVHIVDPREHVFVHAITSECVMLACE 830
Query: 918 VHTGVPEGTSYRWYRDGQPLQESTSATL------RFAAITLTQ---AGAYHCQAQAPGSA 968
V E RWY+DGQ ++ES L R + TQ G + C A +
Sbjct: 831 VDR---EDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAY 887
Query: 969 TTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLH-GDRLVAST 1027
T +S + Y P + L LCR P A++R G+ +V
Sbjct: 888 FTVTITDVSSWIVY-PSGKVYVAAVRLERVVLTCELCR----PWAEVRWTKDGEEVV--- 939
Query: 1028 LQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAV 1087
SP L + RL + LED G Y+CE + AS + V
Sbjct: 940 ---------ESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDE--SASFTVTVTEPPV 988
Query: 1088 NVQVWPGATVREGQLVNLTCLVWTTHPAQ--LTYTWYQDGQQRLDAHSIPL--------- 1136
+ ++P V V L C+V ++ WY+DG + ++ ++ L
Sbjct: 989 RI-IYPRDEVTL-IAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRL 1046
Query: 1137 --PNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNL--RLTYLLESHGGQLALVL 1192
P D + C G S T+ V P + L+ H G V
Sbjct: 1047 VLPAAQPEDGGEFVCDAGDD------SAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVE 1100
Query: 1193 CTVDSRPP-AQLALSHAGRLLASSTAASVPN---TLRLELRGPQPRDEGFYSCSARSPLG 1248
+ P +Q+ G + +S A + T L L QP D G Y C R
Sbjct: 1101 LRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAI 1160
Query: 1249 QANTSLE---LRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEG- 1304
N L ++ + +P P G P+ ++C A AP + W HNGR +QEG
Sbjct: 1161 TFNVILAEPPVQFLALETTPSPLCVAP-GEPVVLSCELSRAGAPVV--WSHNGRPVQEGE 1217
Query: 1305 --------PAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRD 1356
P L A AHAG Y+CQ+ A G S +QV P V
Sbjct: 1218 GLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGA-PSLSFTVQVAEPPVRVVAPEAAQ 1276
Query: 1357 SRARSM--AVIQCTVD-SEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQV 1413
+R RS ++ V S P + DG+ LA+ V +G V L+V
Sbjct: 1277 TRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQV--------LRV 1328
Query: 1414 QDVPAGD-DTYVCTA 1427
Q +GD Y+C A
Sbjct: 1329 QGARSGDAGEYLCDA 1343
Score = 89.7 bits (221), Expect = 2e-17
Identities = 267/1242 (21%), Positives = 418/1242 (33%), Gaps = 214/1242 (17%)
Query: 475 RLEIRDLEETDSGEYKC---SATNSLGNATSTLDFHANAARLLISPAAEV----VEGQAV 527
RL + + + DSGE++C + G H ++ P V + + V
Sbjct: 772 RLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVH------IVDPREHVFVHAITSECV 825
Query: 528 TLSCRSGLSPTPDARFSWYLNG---------ALLHEGPGSSLLLPAASSTDAGSYHCRAR 578
L+C DA WY +G L +EGP L+LPA +D G + C A
Sbjct: 826 MLACEVDRE---DAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAG 882
Query: 579 DGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLH 638
D + + V + + P + + L+ R +L C + P A ++
Sbjct: 883 DECAYFTVTITDVSSWIVYPSGKVYVAAVRLE--------RVVLTCEL-CRPWAEVRWTK 933
Query: 639 KDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNA 698
V S P + + K + R+ + LE+ G YLCE + +
Sbjct: 934 DGEEVVES--------------PALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASF 979
Query: 699 STSATF--------NGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFRNG-- 748
+ + T + T++A+ + L C +SRE A W+++G
Sbjct: 980 TVTVTEPPVRIIYPRDEVTLIAVTLECVV-------LMCELSRE----DAPVRWYKDGLE 1028
Query: 749 -------VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDR--P 799
VL GP + L D + C +AG S ++V PP+R
Sbjct: 1029 VEESEALVLERDGPRCRLVLPAAQPEDGGEFVC----DAGDD-SAFFTVTVTAPPERIVH 1083
Query: 800 KLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSL 859
+ LD+ G + P ++ + G +V + Q AE +
Sbjct: 1084 PAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKD-------GLEVEASDALQLGAEGPTR 1136
Query: 860 KLEVRELGLGDSGSYRCEATNVLGSSNTSLFF-QVRGAWVQVSPSPE-LQEGQAVVLSCQ 917
L + D+G Y CE + + N L V+ ++ +PSP + G+ VVLSC+
Sbjct: 1137 TLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCE 1196
Query: 918 VHTGVPEGTSYRWYRDGQPLQESTSATLR---------FAAITLTQAGAYHCQA-QAPGS 967
+ G W +G+P+QE L A AG Y CQ+ APG+
Sbjct: 1197 LSRA---GAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGA 1253
Query: 968 ATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVAST 1027
+ S ++ V+ P V T RV S P L L+
Sbjct: 1254 PSLS----FTVQVAEPPVRVVAPEAAQT----------RVRSTPGGDLELV-------VH 1292
Query: 1028 LQGVGGPE---------GSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASA 1078
L G GGP S R+ + A L + GA D G Y+C+A
Sbjct: 1293 LSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLV 1352
Query: 1079 SADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPL-P 1137
S + V TV EG C V P TW ++G + +
Sbjct: 1353 SVEEPLLVKLVSELTPLTVHEGDDATFRCEV---SPPDADVTWLRNGAVVTPGPQVEMAQ 1409
Query: 1138 NVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLE------SHGGQLALV 1191
N + R T C +G G + R L +L G + L
Sbjct: 1410 NGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLE 1469
Query: 1192 LCTVDSRPPAQLALSHAGRLLASSTAASVP---NTLRLELRGPQPRDEGFYSCSARSPLG 1248
+ T + G+ L + S+ + RL + G D+G Y C +
Sbjct: 1470 VETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRT 1529
Query: 1249 QANTSLELRLEGVRVILAPE-AAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAA 1307
A L +R +RV+ E + EG T + W G L GP
Sbjct: 1530 LAR--LSVRPRQLRVLRPLEDVTISEGGSATFQL--ELSQEGVTGEWARGGVQLYPGPKC 1585
Query: 1308 SLSF------LVATRAHAGAYSCQAQDAQGTRSS-----RPAALQVLYAPQDAVLSSFRD 1356
+ LV C + A R + R + ++ P D ++
Sbjct: 1586 HIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTE--- 1642
Query: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416
A +C + S+ A++ DG L S + A GT R L+L+ +
Sbjct: 1643 ---GDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGT------RRLLQLR-RCG 1691
Query: 1417 PAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNLSCRL--------- 1467
P+ TY C + + A + + EG C +
Sbjct: 1692 PSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRW 1751
Query: 1468 -LGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHV--ARAQAGMYHCLAELPTGAAASAP 1524
LGG P+ + + H + L R QAG LA L A P
Sbjct: 1752 ELGG-RPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEA---LP 1807
Query: 1525 VMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAE 1584
+ + +PP+ T++V G R +L+ V L G+ L + +
Sbjct: 1808 LQM-CRHPPREKTVLV------GRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHG 1860
Query: 1585 PHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTST 1626
P H L I +RP DQG Y C A G ST T
Sbjct: 1861 P-THSLV--------IHDVRPEDQGTYCCQA----GQDSTHT 1889
Score = 62.0 bits (149), Expect = 5e-09
Identities = 96/410 (23%), Positives = 138/410 (33%), Gaps = 90/410 (21%)
Query: 247 PSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV----------LHLPQAA 296
P ++ G L C V P V + W K G +L + L L A
Sbjct: 18 PRPVRVVSGAEAELKCVVLGEPPPV--VVWEKGGQQLAASERLSFPADGAEHGLLLTAAL 75
Query: 297 WSDAGVYTCQAENGVG--------SLVSPPISLHIFMAEVQVSPA------------GP- 335
+DAGVY C+A N G +++ PP S + P+ GP
Sbjct: 76 PTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPR 135
Query: 336 ---ILENQTVTLVCNTPNEAPSDLRYS---------WYKNHVLLEDAHSH-------TLR 376
+L V L C L + W +H L+ + LR
Sbjct: 136 SQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALR 195
Query: 377 LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVV 436
+ A D+G Y C +N HG ++G + + V+ PP +P E A +V L C+
Sbjct: 196 ILAARLPDSGVYVCHARNAHGHAQAGAL-LQVHQPPESPPADPD-EAPAPVVEPLKCAP- 252
Query: 437 SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSG-----PNSLRLEIRD----------- 480
T ++ G H P P+ RL RD
Sbjct: 253 ----KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLY 308
Query: 481 LEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQ---AVTLSCRSGLSP 537
+ D G Y C+A NS G S + H RL + + VEG+ L C+ S
Sbjct: 309 CQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSR 368
Query: 538 TPDARFSWYLNGALL---------HEGPGSSLLLPAASSTDAGSYHCRAR 578
P A W+ L EG L++ + D G Y C R
Sbjct: 369 IPTA---WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMR 415
Score = 55.5 bits (132), Expect = 4e-07
Identities = 92/368 (25%), Positives = 129/368 (35%), Gaps = 78/368 (21%)
Query: 1186 GQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLR---LELRGPQPRDEGFYSCS 1242
G A + C V PP + G+ LA+S S P L L P D G Y C
Sbjct: 26 GAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCR 85
Query: 1243 ARSPLGQANTSLELRL-----------------------EGVRVILAPEAA--VPEGAPI 1277
AR+ G+A + + + EG V L + V GA +
Sbjct: 86 ARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEV 145
Query: 1278 TVTCADPAAHAPTLYTWYHNGRWLQE----------------GPAASLS--FLVATRAHA 1319
+TC PTLY W +G L E GP ASL+ L A +
Sbjct: 146 VLTCRAGGLPEPTLY-WEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDS 204
Query: 1320 GAYSCQAQDAQGTRSSRPAALQVLYAPQD----------AVLSSFRDS------RARSMA 1363
G Y C A++A G + A LQV P+ V+ + + A
Sbjct: 205 GVYVCHARNAHG-HAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHA 263
Query: 1364 VIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTY 1423
+C V +P E+ +G+ L G + L Q +D Y
Sbjct: 264 KFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVL--KVLYCQAKD----RGLY 317
Query: 1424 VCTAQNLLGSISTIGRLQVEGARV-VAEPGLDVP--EGAALNLSCRLLGGPGPVGNSTFA 1480
VC A+N G + +L V+ R+ P DV E L C++ P A
Sbjct: 318 VCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKV-----PNSRIPTA 372
Query: 1481 WFWNDRRL 1488
WF D+RL
Sbjct: 373 WFREDQRL 380
Score = 52.4 bits (124), Expect = 4e-06
Identities = 108/442 (24%), Positives = 153/442 (34%), Gaps = 94/442 (21%)
Query: 554 EGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPR-----QPTFTTRLD 608
+G LLL AA TDAG Y CRAR ++A + A +TVL PP QP L
Sbjct: 63 DGAEHGLLLTAALPTDAGVYVCRAR--NAAGEAYAAAAVTVLEPPASDPELQPA-ERPLP 119
Query: 609 LDAAGAGA--------------GRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCS 654
+G GA G +L CR P L KD + + +
Sbjct: 120 SPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTL-YWEKDGMALDEVWDSSHFA 178
Query: 655 TCGGCSPRMKVTKAPNL-LRVEIHNPLLEEEGLYLCEASNALGNASTSATFN-------- 705
G + P L + I L + G+Y+C A NA G+A A
Sbjct: 179 LQPG-----RAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP 233
Query: 706 ----GQATVLAIAP------SHTLQEGTEANLTCNVSREAAGSP-ANFSWFRNGVLWAQG 754
+A + P + + EG A C V G P W W
Sbjct: 234 PADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYV----MGKPEPEIEWH-----WEGR 284
Query: 755 PL---------------ETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRP 799
PL + +L D LY C AG LS V L V P R
Sbjct: 285 PLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSA-VQLHVKEP--RL 341
Query: 800 KLSALLDMGQGH---MALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEA 856
+ + L +G +A+ C V + + + LL +++ E
Sbjct: 342 RFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCR---------KYEQIEEG 392
Query: 857 NSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSP-ELQEGQAVVLS 915
+L + L D G Y CE + G T V+G ++ P ++ EG+ VL
Sbjct: 393 TVRRLIIHRLKADDDGIYLCE---MRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLL 449
Query: 916 CQVHTGVPEGTSYRWYRDGQPL 937
+ + G RW RDG+ L
Sbjct: 450 VET---LEAGVEGRWSRDGEEL 468
Score = 49.3 bits (116), Expect = 3e-05
Identities = 146/666 (21%), Positives = 232/666 (34%), Gaps = 127/666 (19%)
Query: 898 VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYR---------------WYRDGQPLQESTS 942
VQ S + +QE +LS Q + TS R WY+DGQ ++ES
Sbjct: 702 VQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESEL 761
Query: 943 ATLR---------FAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLM 993
++ + +G + C+ + + +H+ HV + +
Sbjct: 762 LVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAI- 820
Query: 994 DTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLE 1053
+L C VD + A +R + V + V EG RL V P T
Sbjct: 821 ---TSECVMLACEVDRE-DAPVRWYKDGQEVEESDFVVLENEGPHRRL---VLPAT---- 869
Query: 1054 IHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVW---PG-----ATVREGQLVNL 1105
D G + C A + A F +V W P A VR ++V L
Sbjct: 870 ----QPSDGGEFQCVAGD------ECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVV-L 918
Query: 1106 TCLV---WTTHPAQLTYTWYQDGQQRLDA-----------HSIPLPNVTVRDATSYRCGV 1151
TC + W W +DG++ +++ + LP V + D+ Y C +
Sbjct: 919 TCELCRPWA------EVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEI 972
Query: 1152 GPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVD--------SRPPAQL 1203
S T+ V P +R+ Y + ++ L+ T++ SR A +
Sbjct: 973 DDE------SASFTVTVTEPP--VRIIYPRD----EVTLIAVTLECVVLMCELSREDAPV 1020
Query: 1204 ALSHAGRLLASSTAASVPN---TLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG 1260
G + S A + RL L QP D G + C A ++ E
Sbjct: 1021 RWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPER 1080
Query: 1261 VRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQ---------EGPAASLSF 1311
+ A + GAP V A A + WY +G ++ EGP +L+
Sbjct: 1081 IVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTL 1140
Query: 1312 LVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDS 1371
A AG Y C+ + T + A V + + S + + V+ C + S
Sbjct: 1141 PHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPV-VLSCEL-S 1198
Query: 1372 EPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLL 1431
A + SH+G+ + G+ H + R L +Q PA Y C +
Sbjct: 1199 RAGAPVVWSHNGRPVQEGEGLEL------HAEGPRRVLCIQAAG-PAHAGLYTCQSGAAP 1251
Query: 1432 GSISTIGRLQV--EGARVVAEPGLDV----PEGAALNLSCRLLGGPGPVGNSTFAWFWND 1485
G+ S +QV RVVA G L L L G GPV W+ +
Sbjct: 1252 GAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPV-----RWYKDG 1306
Query: 1486 RRLHAE 1491
RL ++
Sbjct: 1307 ERLASQ 1312
Score = 37.0 bits (84), Expect = 0.16
Identities = 75/352 (21%), Positives = 116/352 (32%), Gaps = 89/352 (25%)
Query: 683 EEGLYLCEASNALGNASTSATFN-------------------------GQATVLAIAPSH 717
+ G+Y+C A NA G A +A G L S
Sbjct: 78 DAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQ 137
Query: 718 TLQEGTEANLTCNVSREAAGSPA-NFSWFRNGV----LW------------AQGPLETVT 760
+ G E LTC A G P W ++G+ +W GP ++
Sbjct: 138 WVLRGAEVVLTCR----AGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLA 193
Query: 761 L--LPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSA--------------- 803
L L D+ +Y C G LL V PP+ P
Sbjct: 194 LRILAARLPDSGVYVCHARNAHG-HAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAP 252
Query: 804 -LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLE 862
+ +G A F C V +P + +H E P +P R + L+
Sbjct: 253 KTFWVNEGKHAKFRCYVMGKPEPEIE-WHWEGR------PLLPDRRRLMYRDRDGGFVLK 305
Query: 863 VRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQ---AVVLSCQV- 918
V D G Y C A N G + +++ V+ ++ + + EG+ VL C+V
Sbjct: 306 VLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVP 365
Query: 919 HTGVPEGTSYRWYRDGQPL---------QESTSATLRFAAITLTQAGAYHCQ 961
++ +P W+R+ Q L +E T L + G Y C+
Sbjct: 366 NSRIPTA----WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCE 413
Score = 35.0 bits (79), Expect = 0.63
Identities = 31/106 (29%), Positives = 40/106 (37%), Gaps = 17/106 (16%)
Query: 1517 TGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASS 1576
+G S P LR P V G L C V EP + G + +A+S
Sbjct: 5 SGDQGSPPCFLRFPRP---------VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAAS 55
Query: 1577 QPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
+ PA+ H L AL P+D G Y+C A N G A
Sbjct: 56 ERLSFPADGAEHGLLLTAAL--------PTDAGVYVCRARNAAGEA 93
Score = 31.6 bits (70), Expect = 6.9
Identities = 69/292 (23%), Positives = 101/292 (34%), Gaps = 62/292 (21%)
Query: 100 LLLKDLQPEDSGSY--NFRFEISEVNRWSDVKGTLVTVTEEP----RVPTIASPVELLEG 153
L L QPED+G Y R E N V + E P + T SP+ + G
Sbjct: 1138 LTLPHAQPEDAGEYVCETRHEAITFN---------VILAEPPVQFLALETTPSPLCVAPG 1188
Query: 154 TEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGR 213
V +C + + W R V + E G L + + H
Sbjct: 1189 EPVVLSCELS----RAGAPVVWSHN--GRPVQ-EGEGLELHAEGPRRVLCIQAAGPAHAG 1241
Query: 214 ILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNIL---PGELVTLTCQVNSSYPA 270
+ CQ A +QV P V+++ + + + PG + L V+ S P
Sbjct: 1242 LYTCQSGAAPGAPSLSFTVQVAEPP--VRVVAPEAAQTRVRSTPGGDLELV--VHLSGPG 1297
Query: 271 VSSIKWLKDGVRLQTK----------TGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPIS 320
++W KDG RL ++ VL + A DAG Y C A P
Sbjct: 1298 -GPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDA----------PQD 1346
Query: 321 LHIFMAEVQ-------VSPAGPIL--ENQTVTLVCNTPNEAPSDLRYSWYKN 363
IF+ V+ VS P+ E T C +P D +W +N
Sbjct: 1347 SRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEV---SPPDADVTWLRN 1395
>gi|193794821 sialic acid binding Ig-like lectin 6 isoform 1
precursor [Homo sapiens]
Length = 453
Score = 100 bits (248), Expect = 2e-20
Identities = 96/357 (26%), Positives = 152/357 (42%), Gaps = 44/357 (12%)
Query: 4 LPKLL-LLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYD 62
LP LL LL + A + + + P+ + +G C+L+PC +P Y+
Sbjct: 13 LPLLLPLLWAGALAQERRFQLEGPESLTVQEGLCVLVPCRLP----TTLPASYYGYGYWF 68
Query: 63 YSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEV 122
G V+ + + V+ RGR + +P + C+L ++D + D+ +Y FR + +
Sbjct: 69 LEGADVPVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWM 128
Query: 123 NRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPAR 182
V V P I+ P L G + CS P+VC Q G P
Sbjct: 129 KYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQ--------GTPPI- 179
Query: 183 SVTFNSQKFEPTGVGHLETLHMAMSW----QDHGRILRCQLSV--ANHRAQSEIHLQVKY 236
F+ PT +G T ++ QDH L CQ++ A + I L V Y
Sbjct: 180 ---FSWMSAAPTSLGPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSY 236
Query: 237 APKGV------------KILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ 284
AP+ V KIL + S +L G+ + L C + + PA + W + L
Sbjct: 237 APQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPA--HLSWFQGFPALN 294
Query: 285 ----TKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPIL 337
+ TGVL LPQ ++ G +TC+A++ +GSL ISL +F+ AG +L
Sbjct: 295 ATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSL---QISLSLFVHWKPEGRAGGVL 348
Score = 54.7 bits (130), Expect = 8e-07
Identities = 53/186 (28%), Positives = 73/186 (39%), Gaps = 26/186 (13%)
Query: 1093 PGATVREGQLVNLTCLV-WTTHPAQLT-YTWYQDGQQRLDAHSIPLPNVTVRD-----AT 1145
PG T+ G NLTC V W ++W L + +T+ +T
Sbjct: 153 PG-TLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSLGPRTTQSSVLTITPRPQDHST 211
Query: 1146 SYRCGVGPPGRAPRLSRPITLDVLYAPRNLRL---------------TYLLESHGGQLAL 1190
+ C V PG + R I L+V YAP+ + + T L GQ
Sbjct: 212 NLTCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALR 271
Query: 1191 VLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQA 1250
+LC D PPA L+ L A + NT LEL +EG ++C A+ PLG
Sbjct: 272 LLCDADGNPPAHLSWFQGFPAL---NATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSL 328
Query: 1251 NTSLEL 1256
SL L
Sbjct: 329 QISLSL 334
Score = 50.8 bits (120), Expect = 1e-05
Identities = 49/193 (25%), Positives = 78/193 (40%), Gaps = 36/193 (18%)
Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPLET----VTLLPVARTDAALY 772
TL+ G +NLTC+V G+P FSW + + GP T +T+ P + +
Sbjct: 155 TLESGHPSNLTCSVPWVCEQGTPPIFSWM-SAAPTSLGPRTTQSSVLTITPRPQDHSTNL 213
Query: 773 ACRI-LTEAGAQLSTPVLLSVLYPPDRPKLSAL---------------LDMGQGHMALFI 816
C++ AG + + L+V Y P + +S L + +G +
Sbjct: 214 TCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLL 273
Query: 817 CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRC 876
C D P A L+ F G L A +N+ LE+ ++G + G + C
Sbjct: 274 CDADGNPPAHLSWFQGFPAL--------------NATPISNTGVLELPQVGSAEEGDFTC 319
Query: 877 EATNVLGSSNTSL 889
A + LGS SL
Sbjct: 320 RAQHPLGSLQISL 332
Score = 45.4 bits (106), Expect = 5e-04
Identities = 55/236 (23%), Positives = 84/236 (35%), Gaps = 62/236 (26%)
Query: 886 NTSLFFQVRGAWVQ--------------------VSPSPELQEGQAVVLSCQVHTGVPEG 925
N + FF+++ W++ +S L+ G L+C V +G
Sbjct: 116 NAAYFFRLKSKWMKYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQG 175
Query: 926 TS--YRWYRDGQPLQESTSATLRFAAITLTQAGAYH-----CQAQAPGSATTSLAAPISL 978
T + W P T + + +T+T H CQ PG+ T + I L
Sbjct: 176 TPPIFSWM-SAAPTSLGPRTT-QSSVLTITPRPQDHSTNLTCQVTFPGAGVT-MERTIQL 232
Query: 979 HVSYAPRHVTL---------------TTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRL 1023
+VSYAP+ V + T+ + G+ LLC D +PPA L G
Sbjct: 233 NVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQG--- 289
Query: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASAS 1079
P L+ NT LE+ +EG + C A + LG S
Sbjct: 290 --------------FPALNATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQIS 331
Score = 31.2 bits (69), Expect = 9.0
Identities = 19/67 (28%), Positives = 32/67 (47%), Gaps = 5/67 (7%)
Query: 335 PILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLED---AHSHTLRLHLATRADTGFYFCE 391
P+LE Q + L+C+ P+ L SW++ L +++ L L A+ G + C
Sbjct: 263 PVLEGQALRLLCDADGNPPAHL--SWFQGFPALNATPISNTGVLELPQVGSAEEGDFTCR 320
Query: 392 VQNVHGS 398
Q+ GS
Sbjct: 321 AQHPLGS 327
>gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Homo
sapiens]
Length = 602
Score = 99.4 bits (246), Expect = 3e-20
Identities = 114/450 (25%), Positives = 182/450 (40%), Gaps = 70/450 (15%)
Query: 5 PKLLLLASFFPAGQA-------SWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITA 57
P++LLL P A S+ + + V +G C+++ C S+P D D TA
Sbjct: 11 PEMLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDGW--DESTA 68
Query: 58 IWYYDYSGQRQV-----VSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGS 112
+ Y + G+ V+ + + VE R R + G+P C+L+++D Q ED
Sbjct: 69 AYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAW 128
Query: 113 YNFRFEISEVNRWSDVKGT-LVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQV 171
Y FR E R S + + VT + P + P L G V C
Sbjct: 129 YFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTVICV---------- 178
Query: 172 RLQWQGQD-PARSVTFNSQKFEP----TGVGHLETLHMAMSWQDHGRILRCQLSVANH-- 224
W + PA S ++ P H L S QDH L C + +
Sbjct: 179 -FNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGV 237
Query: 225 RAQSEIHLQVKYAPKGVKILLSPSGRNIL------------PGELVTLTCQVNSSYPAVS 272
AQ + L+V YAPK + I +S + L G+ + L C +S PA
Sbjct: 238 SAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPA-- 295
Query: 273 SIKW-LKDGVRLQT-----KTGVLHLPQAAWSDAGVYTCQAENGVG--------SLVSPP 318
++ W L+D V + +T L L D+G YTC+AEN +G S+ PP
Sbjct: 296 TLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPP 355
Query: 319 ISLHIFMAEVQVS--------PAGPILENQTVTLVCNTPNEAPSDLRYS-WYKNHVLLED 369
+L + +++ + + P+LE Q++ LVC T + P+ L ++ W + +
Sbjct: 356 ENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQP 415
Query: 370 AHSHTLRLHLATRADTGFYFCEVQNVHGSE 399
+ L L G + C Q+ GS+
Sbjct: 416 SDPGVLELPPIQMEHEGEFTCHAQHPLGSQ 445
Score = 67.4 bits (163), Expect = 1e-10
Identities = 61/224 (27%), Positives = 93/224 (41%), Gaps = 37/224 (16%)
Query: 1145 TSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY---------------LLESHGGQLA 1189
T C V + R + L V YAP++L ++ LE GQ
Sbjct: 224 TDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFL 283
Query: 1190 LVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQ 1249
+LC DS+PPA L+ R+L+SS P TL LELRG + D G Y+C A + LG
Sbjct: 284 RLLCAADSQPPATLSWVLQDRVLSSSHPWG-PRTLGLELRGVRAGDSGRYTCRAENRLGS 342
Query: 1250 ANTSLELRL----EGVRVILA-------------PEAAVPEGAPITVTCADPAAHAPTLY 1292
+L+L + E +RV+++ V EG + + C ++ P
Sbjct: 343 QQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSS-PPARL 401
Query: 1293 TWYHNGRWL---QEGPAASLSFLVATRAHAGAYSCQAQDAQGTR 1333
+W G+ + Q L H G ++C AQ G++
Sbjct: 402 SWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQ 445
Score = 65.1 bits (157), Expect = 6e-10
Identities = 100/399 (25%), Positives = 148/399 (37%), Gaps = 92/399 (23%)
Query: 634 LQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYL--CEA 691
+++ +DR T P G CS + I + E+E Y E
Sbjct: 95 VEMSTRDRFQLTGDPGKGSCS-------------------LVIRDAQREDEAWYFFRVER 135
Query: 692 SNALGNASTSATFNGQATVLAIAPS----HTLQEGTEANLTCNVSREAAGSPA-NFSWFR 746
+ + ++ S F + T L P TL+ G + C + PA +FSW
Sbjct: 136 GSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSW-- 193
Query: 747 NGVLWAQGPLET---------VTLLPVARTDAALYACRI-LTEAGAQLSTPVLLSVLYPP 796
G A P T ++ P + C + + G V L V Y P
Sbjct: 194 TGA--ALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAP 251
Query: 797 -------DRPKLSAL--------LDMGQGHMALFICTVDSRPLALLALFHGEHLLATS-- 839
SAL L++ +G +C DS+P A L+ + +L++S
Sbjct: 252 KDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHP 311
Query: 840 LGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR----G 895
GP+ +L LE+R + GDSG Y C A N LGS +L V+
Sbjct: 312 WGPR--------------TLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPEN 357
Query: 896 AWVQVS-------------PSPELQEGQAVVLSCQVHTGVPEGTSY-RWYRDGQPLQEST 941
V VS S + EGQ++ L C H+ P S+ RW + P Q S
Sbjct: 358 LRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSD 417
Query: 942 SATLRFAAITLTQAGAYHCQAQAP-GSATTSLAAPISLH 979
L I + G + C AQ P GS SL+ +S+H
Sbjct: 418 PGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLS--LSVH 454
Score = 64.7 bits (156), Expect = 7e-10
Identities = 93/398 (23%), Positives = 148/398 (37%), Gaps = 78/398 (19%)
Query: 843 QVPSHGRFQAKAEAN--SLKLEVRELGLGDSGSY--RCEATNVLGSSNTSLFFQVRGAWV 898
++ + RFQ + S L +R+ D Y R E + + S S F ++ +
Sbjct: 96 EMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTAL 155
Query: 899 QVSPS---PE-LQEGQAVVLSCQVHTGVPE--GTSYRWYRDGQPLQESTSATLRFAAITL 952
P PE L+ GQ V + C + + S+ W + + +T F+ ++
Sbjct: 156 TKKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSF 215
Query: 953 TQAGAYH-----CQAQAPGSATTSLAAPISLHVSYAPRHVTLTT---------------L 992
T + H C S + L V+YAP+ + ++
Sbjct: 216 TPSPQDHDTDLTCHVDFSRKGV-SAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIY 274
Query: 993 MDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRL 1052
++ G+ LLC DS PPA L + DR+++S+ P G P TL L
Sbjct: 275 LEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSS-----HPWG----------PRTLGL 319
Query: 1053 EIHGAMLEDEGVYICEASNTLGQASASADFDAQ-----------------AVNVQVWPGA 1095
E+ G D G Y C A N LG + D Q N+
Sbjct: 320 ELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSL 379
Query: 1096 TVREGQLVNLTCLVWTTHPAQLTYT-WYQ--DGQQRLDAHSIPLPNVTVRDATSYRCGVG 1152
V EGQ + L C+ ++ PA+L++T W Q Q D + LP + + + C
Sbjct: 380 PVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQ 439
Query: 1153 PPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLAL 1190
P L + +L + + LE HGG L L
Sbjct: 440 HP-----------LGSQHVSLSLSVHWKLE-HGGGLGL 465
Score = 56.6 bits (135), Expect = 2e-07
Identities = 54/179 (30%), Positives = 74/179 (41%), Gaps = 33/179 (18%)
Query: 420 FLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIR 479
+LE Q G L C+ S+P ATL +L+S S GP +L LE+R
Sbjct: 274 YLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSS-----------SHPWGPRTLGLELR 322
Query: 480 DLEETDSGEYKCSATNSLGNATSTLD----FHANAARLLISPA-------------AEVV 522
+ DSG Y C A N LG+ LD + R+++S A V+
Sbjct: 323 GVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVL 382
Query: 523 EGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSS---LLLPAASSTDAGSYHCRAR 578
EGQ++ L C + S P AR SW G + S L LP G + C A+
Sbjct: 383 EGQSLRLVCVTHSS--PPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQ 439
Score = 54.7 bits (130), Expect = 8e-07
Identities = 87/345 (25%), Positives = 128/345 (37%), Gaps = 67/345 (19%)
Query: 1226 LELRGPQPRDEG--FYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPE----GAPITV 1279
L +R Q DE F+ S + + S L+ + P+ +PE G P+TV
Sbjct: 116 LVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTV 175
Query: 1280 TC----ADPAAHAPTLYTWYHNGRWL---QEGPAAS----LSFLVATRAHAGAYSCQAQ- 1327
C A AP+ ++W G L + P+ S LSF + + H +C
Sbjct: 176 ICVFNWAFKKCPAPS-FSW--TGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDF 232
Query: 1328 DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR---------------SMAVIQCTVDSE 1372
+G + R L+V YAP+D ++S D+ + + C DS+
Sbjct: 233 SRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQ 292
Query: 1373 PPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLL 1431
PPA L+ +VL++S H T L L+++ V AGD Y C A+N L
Sbjct: 293 PPATLSWVLQDRVLSSS---HPWGPRT---------LGLELRGVRAGDSGRYTCRAENRL 340
Query: 1432 GSISTIGRLQV----EGARVVAE-------------PGLDVPEGAALNLSCRLLGGPGPV 1474
GS L V E RV+ L V EG +L L C P P
Sbjct: 341 GSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSP-PA 399
Query: 1475 GNSTFAWFWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPTGA 1519
S W L + G + C A+ P G+
Sbjct: 400 RLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGS 444
Score = 53.5 bits (127), Expect = 2e-06
Identities = 51/182 (28%), Positives = 77/182 (42%), Gaps = 29/182 (15%)
Query: 1097 VREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAH-------SIPLPNVTVRDATSYRC 1149
V++GQ + L C + PA T +W + +H + L V D+ Y C
Sbjct: 277 VQKGQFLRLLCAADSQPPA--TLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTC 334
Query: 1150 GVGPPGRAPRLSRPITLDVLYAPRNLRLTY------LLESHG---------GQLALVLCT 1194
R + + L V Y P NLR+ +LE+ G GQ ++C
Sbjct: 335 RA--ENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCV 392
Query: 1195 VDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSL 1254
S PPA+L+ + G+ + S + P L EL Q EG ++C A+ PLG + SL
Sbjct: 393 THSSPPARLSWTRWGQTVGPSQPSD-PGVL--ELPPIQMEHEGEFTCHAQHPLGSQHVSL 449
Query: 1255 EL 1256
L
Sbjct: 450 SL 451
Score = 50.1 bits (118), Expect = 2e-05
Identities = 36/119 (30%), Positives = 53/119 (44%), Gaps = 27/119 (22%)
Query: 1518 GAAASAPVMLRVLYPPKTPTM---------------MVFVEPEGGLRGILDCRVDSEPLA 1562
G +A V LRV Y PK + ++++E + G L C DS+P A
Sbjct: 236 GVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPA 295
Query: 1563 SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621
+L+ L R+++SS P G P L +++ +R D G Y C A N LGS
Sbjct: 296 TLSWVLQDRVLSSSHPWG------------PRTLGLELRGVRAGDSGRYTCRAENRLGS 342
Score = 48.9 bits (115), Expect = 4e-05
Identities = 89/372 (23%), Positives = 125/372 (33%), Gaps = 82/372 (22%)
Query: 464 RFSGTSGPNSLRLEIRDLEETDSGEY--KCSATNSLGNATSTLDFHANAARLLISPAAEV 521
+ +G G S L IRD + D Y + + + ++ + F L P +
Sbjct: 104 QLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYI 163
Query: 522 VE----GQAVTLSC--RSGLSPTPDARFSWYLNGALL----------HEGPGSSLLLPAA 565
E GQ VT+ C P FSW GA L H S P
Sbjct: 164 PETLEPGQPVTVICVFNWAFKKCPAPSFSW--TGAALSPRRTRPSTSHFSVLSFTPSPQD 221
Query: 566 SSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAA----------GAG 615
TD + +R G SA L V Y P+ + D +A
Sbjct: 222 HDTDLTCHVDFSRKGVSAQ---RTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQ 278
Query: 616 AGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVE 675
G+ LLC DS PPA L + +DRV+++S P G P L +E
Sbjct: 279 KGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWG------------------PRTLGLE 320
Query: 676 IHNPLLEEEGLYLCEASNALGNASTSATFNGQ--------------ATVLAIAPSHT--- 718
+ + G Y C A N LG+ + + Q TVL + T
Sbjct: 321 LRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLP 380
Query: 719 LQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQ--GPLE-----TVTLLPVARTDAAL 771
+ EG L C + PA SW R W Q GP + + L P+
Sbjct: 381 VLEGQSLRLVCVTH---SSPPARLSWTR----WGQTVGPSQPSDPGVLELPPIQMEHEGE 433
Query: 772 YACRILTEAGAQ 783
+ C G+Q
Sbjct: 434 FTCHAQHPLGSQ 445
Score = 38.1 bits (87), Expect = 0.074
Identities = 50/198 (25%), Positives = 71/198 (35%), Gaps = 39/198 (19%)
Query: 1453 LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP-----VPTLAFTHVARAQAG 1507
L+V +G L L C P +T +W DR L + L V +G
Sbjct: 275 LEVQKGQFLRLLCAADSQPP----ATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSG 330
Query: 1508 MYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGI---------------L 1552
Y C AE G+ A + L V YPP+ +MV L + L
Sbjct: 331 RYTCRAENRLGSQQQA-LDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRL 389
Query: 1553 DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612
C S P A L+ + V SQP + P L ++ ++ +GE+
Sbjct: 390 VCVTHSSPPARLSWTRWGQTVGPSQP------------SDPGVL--ELPPIQMEHEGEFT 435
Query: 1613 CSASNVLGSASTSTYFGV 1630
C A + LGS S V
Sbjct: 436 CHAQHPLGSQHVSLSLSV 453
Score = 32.3 bits (72), Expect = 4.1
Identities = 45/184 (24%), Positives = 71/184 (38%), Gaps = 36/184 (19%)
Query: 336 ILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHS---HTLRLHL--ATRADTGFYFC 390
+ + Q + L+C ++ P+ L SW +L +H TL L L D+G Y C
Sbjct: 277 VQKGQFLRLLCAADSQPPATL--SWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTC 334
Query: 391 EVQNVHGSERSGPVSVVVNHPP------LTPVLTAFLETQAGLVGI---------LHCSV 435
+N GS++ + + V +PP ++ LE + L C
Sbjct: 335 RAENRLGSQQQA-LDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVT 393
Query: 436 VSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATN 495
S P A L + G T G S P G LE+ ++ GE+ C A +
Sbjct: 394 HSSPPARLSWTRWG----QTVGPS--QPSDPGV-------LELPPIQMEHEGEFTCHAQH 440
Query: 496 SLGN 499
LG+
Sbjct: 441 PLGS 444
>gi|193794817 sialic acid binding Ig-like lectin 6 isoform 3
precursor [Homo sapiens]
Length = 353
Score = 99.0 bits (245), Expect = 4e-20
Identities = 93/345 (26%), Positives = 148/345 (42%), Gaps = 44/345 (12%)
Query: 4 LPKLL-LLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYD 62
LP LL LL + A + + + P+ + +G C+L+PC +P Y+
Sbjct: 13 LPLLLPLLWAGALAQERRFQLEGPESLTVQEGLCVLVPCRLP----TTLPASYYGYGYWF 68
Query: 63 YSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEV 122
G V+ + + V+ RGR + +P + C+L ++D + D+ +Y FR + +
Sbjct: 69 LEGADVPVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWM 128
Query: 123 NRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPAR 182
V V P I+ P L G + CS P+VC Q G P
Sbjct: 129 KYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQ--------GTPPI- 179
Query: 183 SVTFNSQKFEPTGVGHLETLHMAMSW----QDHGRILRCQLSV--ANHRAQSEIHLQVKY 236
F+ PT +G T ++ QDH L CQ++ A + I L V Y
Sbjct: 180 ---FSWMSAAPTSLGPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSY 236
Query: 237 APKGV------------KILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ 284
AP+ V KIL + S +L G+ + L C + + PA + W + L
Sbjct: 237 APQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPA--HLSWFQGFPALN 294
Query: 285 ----TKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFM 325
+ TGVL LPQ ++ G +TC+A++ +GSL ISL +F+
Sbjct: 295 ATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSL---QISLSLFV 336
Score = 54.7 bits (130), Expect = 8e-07
Identities = 53/186 (28%), Positives = 73/186 (39%), Gaps = 26/186 (13%)
Query: 1093 PGATVREGQLVNLTCLV-WTTHPAQLT-YTWYQDGQQRLDAHSIPLPNVTVRD-----AT 1145
PG T+ G NLTC V W ++W L + +T+ +T
Sbjct: 153 PG-TLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSLGPRTTQSSVLTITPRPQDHST 211
Query: 1146 SYRCGVGPPGRAPRLSRPITLDVLYAPRNLRL---------------TYLLESHGGQLAL 1190
+ C V PG + R I L+V YAP+ + + T L GQ
Sbjct: 212 NLTCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALR 271
Query: 1191 VLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQA 1250
+LC D PPA L+ L A + NT LEL +EG ++C A+ PLG
Sbjct: 272 LLCDADGNPPAHLSWFQGFPAL---NATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSL 328
Query: 1251 NTSLEL 1256
SL L
Sbjct: 329 QISLSL 334
Score = 50.8 bits (120), Expect = 1e-05
Identities = 49/193 (25%), Positives = 78/193 (40%), Gaps = 36/193 (18%)
Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPLET----VTLLPVARTDAALY 772
TL+ G +NLTC+V G+P FSW + + GP T +T+ P + +
Sbjct: 155 TLESGHPSNLTCSVPWVCEQGTPPIFSWM-SAAPTSLGPRTTQSSVLTITPRPQDHSTNL 213
Query: 773 ACRI-LTEAGAQLSTPVLLSVLYPPDRPKLSAL---------------LDMGQGHMALFI 816
C++ AG + + L+V Y P + +S L + +G +
Sbjct: 214 TCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLL 273
Query: 817 CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRC 876
C D P A L+ F G L A +N+ LE+ ++G + G + C
Sbjct: 274 CDADGNPPAHLSWFQGFPAL--------------NATPISNTGVLELPQVGSAEEGDFTC 319
Query: 877 EATNVLGSSNTSL 889
A + LGS SL
Sbjct: 320 RAQHPLGSLQISL 332
Score = 45.4 bits (106), Expect = 5e-04
Identities = 55/236 (23%), Positives = 84/236 (35%), Gaps = 62/236 (26%)
Query: 886 NTSLFFQVRGAWVQ--------------------VSPSPELQEGQAVVLSCQVHTGVPEG 925
N + FF+++ W++ +S L+ G L+C V +G
Sbjct: 116 NAAYFFRLKSKWMKYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQG 175
Query: 926 TS--YRWYRDGQPLQESTSATLRFAAITLTQAGAYH-----CQAQAPGSATTSLAAPISL 978
T + W P T + + +T+T H CQ PG+ T + I L
Sbjct: 176 TPPIFSWM-SAAPTSLGPRTT-QSSVLTITPRPQDHSTNLTCQVTFPGAGVT-MERTIQL 232
Query: 979 HVSYAPRHVTL---------------TTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRL 1023
+VSYAP+ V + T+ + G+ LLC D +PPA L G
Sbjct: 233 NVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQG--- 289
Query: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASAS 1079
P L+ NT LE+ +EG + C A + LG S
Sbjct: 290 --------------FPALNATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQIS 331
Score = 31.2 bits (69), Expect = 9.0
Identities = 19/67 (28%), Positives = 32/67 (47%), Gaps = 5/67 (7%)
Query: 335 PILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLED---AHSHTLRLHLATRADTGFYFCE 391
P+LE Q + L+C+ P+ L SW++ L +++ L L A+ G + C
Sbjct: 263 PVLEGQALRLLCDADGNPPAHL--SWFQGFPALNATPISNTGVLELPQVGSAEEGDFTCR 320
Query: 392 VQNVHGS 398
Q+ GS
Sbjct: 321 AQHPLGS 327
>gi|193794819 sialic acid binding Ig-like lectin 6 isoform 2
precursor [Homo sapiens]
Length = 437
Score = 96.7 bits (239), Expect = 2e-19
Identities = 90/343 (26%), Positives = 147/343 (42%), Gaps = 32/343 (9%)
Query: 4 LPKLL-LLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYD 62
LP LL LL + A + + + P+ + +G C+L+PC +P Y+
Sbjct: 13 LPLLLPLLWAGALAQERRFQLEGPESLTVQEGLCVLVPCRLP----TTLPASYYGYGYWF 68
Query: 63 YSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEV 122
G V+ + + V+ RGR + +P + C+L ++D + D+ +Y FR + +
Sbjct: 69 LEGADVPVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWM 128
Query: 123 NRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPAR 182
V V P I+ P L G + CS P+VC Q G P
Sbjct: 129 KYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQ--------GTPPI- 179
Query: 183 SVTFNSQKFEPTGVGHLETLHMAMSW----QDHGRILRCQLSVANHRAQSEIHLQVKYAP 238
F+ PT +G T ++ QDH L CQ++ E +Q+ +
Sbjct: 180 ---FSWMSAAPTSLGPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVS- 235
Query: 239 KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ----TKTGVLHLPQ 294
KIL + S +L G+ + L C + + PA + W + L + TGVL LPQ
Sbjct: 236 -SFKILQNTSSLPVLEGQALRLLCDADGNPPA--HLSWFQGFPALNATPISNTGVLELPQ 292
Query: 295 AAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPIL 337
++ G +TC+A++ +GSL ISL +F+ AG +L
Sbjct: 293 VGSAEEGDFTCRAQHPLGSL---QISLSLFVHWKPEGRAGGVL 332
Score = 51.2 bits (121), Expect = 8e-06
Identities = 51/171 (29%), Positives = 71/171 (41%), Gaps = 12/171 (7%)
Query: 1093 PGATVREGQLVNLTCLV-WTTHPAQLT-YTWYQDGQQRLDAHSIPLPNVTVRD-----AT 1145
PG T+ G NLTC V W ++W L + +T+ +T
Sbjct: 153 PG-TLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSLGPRTTQSSVLTITPRPQDHST 211
Query: 1146 SYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLAL 1205
+ C V PG + R I L+V + + L+ T L GQ +LC D PPA L+
Sbjct: 212 NLTCQVTFPGAGVTMERTIQLNVS-SFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSW 270
Query: 1206 SHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLEL 1256
L A + NT LEL +EG ++C A+ PLG SL L
Sbjct: 271 FQGFPAL---NATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQISLSL 318
Score = 46.2 bits (108), Expect = 3e-04
Identities = 47/178 (26%), Positives = 75/178 (42%), Gaps = 22/178 (12%)
Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPLET----VTLLPVARTDAALY 772
TL+ G +NLTC+V G+P FSW + + GP T +T+ P + +
Sbjct: 155 TLESGHPSNLTCSVPWVCEQGTPPIFSWM-SAAPTSLGPRTTQSSVLTITPRPQDHSTNL 213
Query: 773 ACRI-LTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFH 831
C++ AG + + L+V S+L + +G +C D P A L+ F
Sbjct: 214 TCQVTFPGAGVTMERTIQLNVSSFKILQNTSSLPVL-EGQALRLLCDADGNPPAHLSWFQ 272
Query: 832 GEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSL 889
G L A +N+ LE+ ++G + G + C A + LGS SL
Sbjct: 273 GFPAL--------------NATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQISL 316
Score = 38.9 bits (89), Expect = 0.043
Identities = 51/221 (23%), Positives = 81/221 (36%), Gaps = 48/221 (21%)
Query: 886 NTSLFFQVRGAWVQ--------------------VSPSPELQEGQAVVLSCQVHTGVPEG 925
N + FF+++ W++ +S L+ G L+C V +G
Sbjct: 116 NAAYFFRLKSKWMKYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQG 175
Query: 926 TS--YRWYRDGQPLQESTSATLRFAAITLTQAGAYH-----CQAQAPGSATTSLAAPISL 978
T + W P T + + +T+T H CQ PG+ T + I L
Sbjct: 176 TPPIFSWM-SAAPTSLGPRTT-QSSVLTITPRPQDHSTNLTCQVTFPGAGVT-MERTIQL 232
Query: 979 HVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSS 1038
+VS + + + T+ + G+ LLC D +PPA L G
Sbjct: 233 NVS-SFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQG-----------------F 274
Query: 1039 PRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASAS 1079
P L+ NT LE+ +EG + C A + LG S
Sbjct: 275 PALNATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQIS 315
Score = 35.8 bits (81), Expect = 0.37
Identities = 30/119 (25%), Positives = 54/119 (45%), Gaps = 7/119 (5%)
Query: 285 TKTGVLHLPQAAWSDAGVYTCQAE-NGVGSLVSPPISLHIFMAEV-QVSPAGPILENQTV 342
T++ VL + + TCQ G G + I L++ ++ Q + + P+LE Q +
Sbjct: 195 TQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSSFKILQNTSSLPVLEGQAL 254
Query: 343 TLVCNTPNEAPSDLRYSWYKNHVLLED---AHSHTLRLHLATRADTGFYFCEVQNVHGS 398
L+C+ P+ L SW++ L +++ L L A+ G + C Q+ GS
Sbjct: 255 RLLCDADGNPPAHL--SWFQGFPALNATPISNTGVLELPQVGSAEEGDFTCRAQHPLGS 311
>gi|23943856 sialic acid binding Ig-like lectin 9 [Homo sapiens]
Length = 463
Score = 96.3 bits (238), Expect = 2e-19
Identities = 89/323 (27%), Positives = 135/323 (41%), Gaps = 37/323 (11%)
Query: 17 GQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSG----QRQVVSH 72
GQ S ++ V +G C+ +PC FS+P+ + G Y+ G Q V+
Sbjct: 17 GQTSKLLTMQSSVTVQEGLCVHVPCSFSYPSHGWIYPGPVVHGYWFREGANTDQDAPVAT 76
Query: 73 SADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTL 132
+ + V R R +G+P + C L ++D + D+G Y FR E + +W+ L
Sbjct: 77 NNPARAVWEETRDRFHLLGDPHTKNCTLSIRDARRSDAGRYFFRMEKGSI-KWNYKHHRL 135
Query: 133 -VTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKF 191
V VT P I P L G + CS P+ C QG P S S
Sbjct: 136 SVNVTALTHRPNILIPGTLESGCPQNLTCSVPWAC--------EQGTPPMISWIGTSVSP 187
Query: 192 EPTGVGHLETLHMAMSWQDHGRILRCQLSV--ANHRAQSEIHLQVKYAPKGV-------- 241
L + QDHG L CQ++ A+ +HL V Y P+ +
Sbjct: 188 LDPSTTRSSVLTLIPQPQDHGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGD 247
Query: 242 ----KILLSPSGRNILPGELVTLTC---QVNSSYPAVSSIKWLKDGVRL----QTKTGVL 290
+L + S ++ G+ + L C V+S+ PA S+ W G+ L + GVL
Sbjct: 248 GTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSLSW--RGLTLCPSQPSNPGVL 305
Query: 291 HLPQAAWSDAGVYTCQAENGVGS 313
LP DA +TC+A+N +GS
Sbjct: 306 ELPWVHLRDAAEFTCRAQNPLGS 328
Score = 54.7 bits (130), Expect = 8e-07
Identities = 72/263 (27%), Positives = 98/263 (37%), Gaps = 47/263 (17%)
Query: 1035 EGSSPRLHVAVAPNTLR--LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVW 1092
E + R H+ P+T L I A D G Y G + +VNV
Sbjct: 85 EETRDRFHLLGDPHTKNCTLSIRDARRSDAGRYFFRMEK--GSIKWNYKHHRLSVNVTAL 142
Query: 1093 --------PGATVREGQLVNLTCLV-WTTHPAQLTY-TWYQDGQQRLDAHS--------I 1134
PG T+ G NLTC V W +W LD + I
Sbjct: 143 THRPNILIPG-TLESGCPQNLTCSVPWACEQGTPPMISWIGTSVSPLDPSTTRSSVLTLI 201
Query: 1135 PLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY--------------- 1179
P P TS C V PG + ++ + L+V Y P+NL +T
Sbjct: 202 PQPQ---DHGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGS 258
Query: 1180 ---LLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDE 1236
L E +L + VDS PPA+L+LS G L S + N LEL RD
Sbjct: 259 SLSLPEGQSLRLVCAVDAVDSNPPARLSLSWRGLTLCPSQPS---NPGVLELPWVHLRDA 315
Query: 1237 GFYSCSARSPLGQANTSLELRLE 1259
++C A++PLG L + L+
Sbjct: 316 AEFTCRAQNPLGSQQVYLNVSLQ 338
Score = 46.6 bits (109), Expect = 2e-04
Identities = 55/200 (27%), Positives = 78/200 (39%), Gaps = 47/200 (23%)
Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPLE-------TVTLLPVARTDA 769
TL+ G NLTC+V G+P SW V PL+ +TL+P +
Sbjct: 153 TLESGCPQNLTCSVPWACEQGTPPMISWIGTSV----SPLDPSTTRSSVLTLIPQPQDHG 208
Query: 770 ALYACRILTEAGAQLST--PVLLSVLYPPDRPKLSAL---------------LDMGQGHM 812
C++ T GA ++T V L+V YPP ++ L + +G
Sbjct: 209 TSLTCQV-TFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQS 267
Query: 813 ALFICTVD---SRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLG 869
+C VD S P A L+L +L P PS N LE+ + L
Sbjct: 268 LRLVCAVDAVDSNPPARLSL----SWRGLTLCPSQPS----------NPGVLELPWVHLR 313
Query: 870 DSGSYRCEATNVLGSSNTSL 889
D+ + C A N LGS L
Sbjct: 314 DAAEFTCRAQNPLGSQQVYL 333
Score = 42.0 bits (97), Expect = 0.005
Identities = 52/205 (25%), Positives = 79/205 (38%), Gaps = 43/205 (20%)
Query: 906 LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYH-----C 960
L+ G L+C V +GT G + +T R + +TL H C
Sbjct: 154 LESGCPQNLTCSVPWACEQGTPPMISWIGTSVSPLDPSTTRSSVLTLIPQPQDHGTSLTC 213
Query: 961 QAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTG---------------PGRLGLLLC 1005
Q PG++ T+ + L+VSY P+++T+T G G+ L+C
Sbjct: 214 QVTFPGASVTTNKT-VHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVC 272
Query: 1006 ---RVDSDPPAQLRL-LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLED 1061
VDS+PPA+L L G L S + S+P + LE+ L D
Sbjct: 273 AVDAVDSNPPARLSLSWRGLTLCPS--------QPSNPGV----------LELPWVHLRD 314
Query: 1062 EGVYICEASNTLGQASASADFDAQA 1086
+ C A N LG + Q+
Sbjct: 315 AAEFTCRAQNPLGSQQVYLNVSLQS 339
Score = 33.5 bits (75), Expect = 1.8
Identities = 48/195 (24%), Positives = 73/195 (37%), Gaps = 39/195 (20%)
Query: 1264 ILAPEAAVPEGAPITVTCADPAA---HAPTLYTWYHNG-RWLQEGPAAS--LSFLVATRA 1317
IL P + G P +TC+ P A P + +W L S L+ + +
Sbjct: 148 ILIP-GTLESGCPQNLTCSVPWACEQGTPPMISWIGTSVSPLDPSTTRSSVLTLIPQPQD 206
Query: 1318 HAGAYSCQAQ-DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV------------ 1364
H + +CQ +++ L V Y PQ+ ++ F+ S +
Sbjct: 207 HGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQ 266
Query: 1365 ---IQCTVD---SEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPA 1418
+ C VD S PPA L+LS G L S S G +++ LR +
Sbjct: 267 SLRLVCAVDAVDSNPPARLSLSWRGLTLCPSQ-----PSNPGVLELPWVHLRDAAE---- 317
Query: 1419 GDDTYVCTAQNLLGS 1433
+ C AQN LGS
Sbjct: 318 ----FTCRAQNPLGS 328
Score = 32.0 bits (71), Expect = 5.3
Identities = 37/115 (32%), Positives = 45/115 (39%), Gaps = 32/115 (27%)
Query: 1525 VMLRVLYPPKTPTMMVFVE----------------PEG-GLRGILDC-RVDSEPLASLTL 1566
V L V YPP+ TM VF PEG LR + VDS P A L+L
Sbjct: 228 VHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSL 287
Query: 1567 HLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGS 1621
+ SQP ++P L + LR D E+ C A N LGS
Sbjct: 288 SWRGLTLCPSQP------------SNPGVLELPWVHLR--DAAEFTCRAQNPLGS 328
>gi|94538343 sialic acid binding Ig-like lectin 8 [Homo sapiens]
Length = 499
Score = 96.3 bits (238), Expect = 2e-19
Identities = 103/401 (25%), Positives = 163/401 (40%), Gaps = 48/401 (11%)
Query: 33 KGSCLLIPCIFSFPADVEVP-DGITAIWYY--DYSGQRQVVSHSADPKLVEARFRGRTEF 89
+G C+ +PC FS+P D D + W+ D Q V+ + + V+A +GR +
Sbjct: 39 EGLCVHVPCSFSYPQDGWTDSDPVHGYWFRAGDRPYQDAPVATNNPDREVQAETQGRFQL 98
Query: 90 MGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWS-------DVKGTLVTVTEEPRVP 142
+G+ C+L ++D + D GSY FR E + +WS K V VT P
Sbjct: 99 LGDIWSNDCSLSIRDARKRDKGSYFFRLERGSM-KWSYKSQLNYKTKQLSVFVTALTHRP 157
Query: 143 TIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETL 202
I L G + CS P+ C QG P S S L
Sbjct: 158 DILILGTLESGHSRNLTCSVPWACK--------QGTPPMISWIGASVSSPGPTTARSSVL 209
Query: 203 HMAMSWQDHGRILRCQLSV--ANHRAQSEIHLQVKYAPKGVKI------------LLSPS 248
+ QDHG L CQ+++ S + L V Y P + + L + S
Sbjct: 210 TLTPKPQDHGTSLTCQVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGS 269
Query: 249 GRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRL----QTKTGVLHLPQAAWSDAGVYT 304
++L G+ + L C VNS+ PA + W + + L + G+L LP+ D G +T
Sbjct: 270 SLSVLEGQSLRLVCAVNSNPPA--RLSWTRGSLTLCPSRSSNPGLLELPRVHVRDEGEFT 327
Query: 305 CQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNH 364
C+A+N G S ISL + + + P+ + VTL A + S+
Sbjct: 328 CRAQNAQG---SQHISLSLSLQNEGTGTSRPVSQ---VTLAAVGGAGATALAFLSFCIIF 381
Query: 365 VLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVS 405
+++ + R A DTG + + + GS GP++
Sbjct: 382 IIVRSCRKKSAR-PAAGVGDTGME--DAKAIRGSASQGPLT 419
Score = 63.2 bits (152), Expect = 2e-09
Identities = 68/276 (24%), Positives = 104/276 (37%), Gaps = 51/276 (18%)
Query: 843 QVPSHGRFQAKAE--ANSLKLEVRELGLGDSGSY--RCEATNVLGSSNTSLFFQVRGAWV 898
Q + GRFQ + +N L +R+ D GSY R E ++ S + L ++ + V
Sbjct: 89 QAETQGRFQLLGDIWSNDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTKQLSV 148
Query: 899 QVSPSPE---------LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAA 949
V+ L+ G + L+C V +GT G + T R +
Sbjct: 149 FVTALTHRPDILILGTLESGHSRNLTCSVPWACKQGTPPMISWIGASVSSPGPTTARSSV 208
Query: 950 ITLTQAGAYH-----CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL-- 1002
+TLT H CQ PG+ T+ + + L VSY P ++T+T L
Sbjct: 209 LTLTPKPQDHGTSLTCQVTLPGTGVTTTST-VRLDVSYPPWNLTMTVFQGDATASTALGN 267
Query: 1003 -------------LLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNT 1049
L+C V+S+PPA+L G + + S+P L
Sbjct: 268 GSSLSVLEGQSLRLVCAVNSNPPARLSWTRGSLTLCPS-------RSSNPGL-------- 312
Query: 1050 LRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQ 1085
LE+ + DEG + C A N G S Q
Sbjct: 313 --LELPRVHVRDEGEFTCRAQNAQGSQHISLSLSLQ 346
Score = 55.5 bits (132), Expect = 4e-07
Identities = 62/245 (25%), Positives = 93/245 (37%), Gaps = 36/245 (14%)
Query: 1048 NTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGA-----------T 1096
N L I A D+G Y + S + + + + V+ A T
Sbjct: 105 NDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGT 164
Query: 1097 VREGQLVNLTCLV-WTTH---PAQLTY---TWYQDGQQRLDAHSIPLPNVTVRDATSYRC 1149
+ G NLTC V W P +++ + G + + L TS C
Sbjct: 165 LESGHSRNLTCSVPWACKQGTPPMISWIGASVSSPGPTTARSSVLTLTPKPQDHGTSLTC 224
Query: 1150 GVGPPGRAPRLSRPITLDVLYAPRNLRLTYL---------------LESHGGQLALVLCT 1194
V PG + + LDV Y P NL +T L GQ ++C
Sbjct: 225 QVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVCA 284
Query: 1195 VDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSL 1254
V+S PPA+L+ + L S ++ N LEL RDEG ++C A++ G + SL
Sbjct: 285 VNSNPPARLSWTRGSLTLCPSRSS---NPGLLELPRVHVRDEGEFTCRAQNAQGSQHISL 341
Query: 1255 ELRLE 1259
L L+
Sbjct: 342 SLSLQ 346
Score = 51.6 bits (122), Expect = 6e-06
Identities = 53/193 (27%), Positives = 75/193 (38%), Gaps = 36/193 (18%)
Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPL----ETVTLLPVARTDAALY 772
TL+ G NLTC+V G+P SW V + GP +TL P +
Sbjct: 164 TLESGHSRNLTCSVPWACKQGTPPMISWIGASVS-SPGPTTARSSVLTLTPKPQDHGTSL 222
Query: 773 ACRI-LTEAGAQLSTPVLLSVLYPP----------DRPKLSAL-----LDMGQGHMALFI 816
C++ L G ++ V L V YPP D +AL L + +G +
Sbjct: 223 TCQVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLV 282
Query: 817 CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRC 876
C V+S P A L+ G L S +N LE+ + + D G + C
Sbjct: 283 CAVNSNPPARLSWTRGSLTLCPS--------------RSSNPGLLELPRVHVRDEGEFTC 328
Query: 877 EATNVLGSSNTSL 889
A N GS + SL
Sbjct: 329 RAQNAQGSQHISL 341
Score = 42.0 bits (97), Expect = 0.005
Identities = 67/268 (25%), Positives = 94/268 (35%), Gaps = 58/268 (21%)
Query: 472 NSLRLEIRDLEETDSGEY---------KCSATNSLGNATSTLDFHANAAR----LLISPA 518
N L IRD + D G Y K S + L T L A +LI
Sbjct: 105 NDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGT 164
Query: 519 AEVVEGQAVTLS----CRSGLSPTPDARFSWYLNGALLHEGPG---SSLLLPAASSTDAG 571
E + +T S C+ G P SW + ++ GP SS+L D G
Sbjct: 165 LESGHSRNLTCSVPWACKQGTPPM----ISW-IGASVSSPGPTTARSSVLTLTPKPQDHG 219
Query: 572 -SYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGA-----------GRR 619
S C+ + +S L V YPP T T DA + A G+
Sbjct: 220 TSLTCQVTLPGTGVTTTSTVRLDVSYPPWNLTMTV-FQGDATASTALGNGSSLSVLEGQS 278
Query: 620 GLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNP 679
L+C V+S+PPARL + S S G +E+
Sbjct: 279 LRLVCAVNSNPPARLSWTRGSLTLCPSRSSNPGL--------------------LELPRV 318
Query: 680 LLEEEGLYLCEASNALGNASTSATFNGQ 707
+ +EG + C A NA G+ S + + Q
Sbjct: 319 HVRDEGEFTCRAQNAQGSQHISLSLSLQ 346
Score = 38.5 bits (88), Expect = 0.057
Identities = 37/131 (28%), Positives = 51/131 (38%), Gaps = 30/131 (22%)
Query: 1511 CLAELP-TGAAASAPVMLRVLYPPKTPTMMVF--------VEPEGGLRGILD-------C 1554
C LP TG ++ V L V YPP TM VF G +L+ C
Sbjct: 224 CQVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVC 283
Query: 1555 RVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICS 1614
V+S P A L+ GS + S+ S N +++ + D+GE+ C
Sbjct: 284 AVNSNPPARLSWTRGSLTLCPSR--------------SSNPGLLELPRVHVRDEGEFTCR 329
Query: 1615 ASNVLGSASTS 1625
A N GS S
Sbjct: 330 AQNAQGSQHIS 340
Score = 37.4 bits (85), Expect = 0.13
Identities = 64/277 (23%), Positives = 105/277 (37%), Gaps = 53/277 (19%)
Query: 1222 NTLRLELRGPQPRDEGFY---------SCSARSPLGQANTSLELRLEGV--RVILAPEAA 1270
N L +R + RD+G Y S +S L L + + + R +
Sbjct: 105 NDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGT 164
Query: 1271 VPEGAPITVTCADPAA---HAPTLYTWYHNGRWLQEGPAASLSFLVAT----RAHAGAYS 1323
+ G +TC+ P A P + +W GP + S ++ + H + +
Sbjct: 165 LESGHSRNLTCSVPWACKQGTPPMISWI-GASVSSPGPTTARSSVLTLTPKPQDHGTSLT 223
Query: 1324 CQAQ-DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV---------------IQC 1367
CQ G ++ L V Y P + ++ F+ S A+ + C
Sbjct: 224 CQVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVC 283
Query: 1368 TVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTA 1427
V+S PPA L+ + L S +S G +++ R+ V+D + + C A
Sbjct: 284 AVNSNPPARLSWTRGSLTLCPSR-----SSNPGLLELP----RVHVRD----EGEFTCRA 330
Query: 1428 QNLLGS--ISTIGRLQVEG---ARVVAEPGLDVPEGA 1459
QN GS IS LQ EG +R V++ L GA
Sbjct: 331 QNAQGSQHISLSLSLQNEGTGTSRPVSQVTLAAVGGA 367
>gi|16506826 sialic acid binding immunoglobulin-like lectin-like
protein 1 isoform b precursor [Homo sapiens]
Length = 477
Score = 95.5 bits (236), Expect = 4e-19
Identities = 82/310 (26%), Positives = 135/310 (43%), Gaps = 33/310 (10%)
Query: 26 PQDVQGVKGSCLLIPCIFSFPA-DVEVPDGITAIWYY---DYSGQRQVVSHSADPKLVEA 81
P+ V +G C+ +PC +P + + W+ D V +++ K+ E
Sbjct: 38 PESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQED 97
Query: 82 RFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTL-VTVTEEPR 140
GR +G+P+ C+L ++D + DSG Y F+ E +W+ + L V VT
Sbjct: 98 T-HGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGS-RKWNYIYDKLSVHVTALTH 155
Query: 141 VPTIASPVELLEGTEVDFNCSTPYVCLQ-EQVRLQWQGQDPARSVTFNSQKFEPTGVGHL 199
+PT + P L G + CS P+ C Q + W G + +PT +
Sbjct: 156 MPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGA--------SVSSLDPT-ITRS 206
Query: 200 ETLHMAMSWQDHGRILRCQLSV--ANHRAQSEIHLQVKYAPKGVKI------------LL 245
L + QDHG L CQ+++ A + L + Y P+ + + L
Sbjct: 207 SMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLR 266
Query: 246 SPSGRNILPGELVTLTCQVNSSYPAVSSIKW--LKDGVRLQTKTGVLHLPQAAWSDAGVY 303
+ S ++L G+ + L C V+S+ PA S W L + GVL LP+ D G +
Sbjct: 267 NGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEF 326
Query: 304 TCQAENGVGS 313
TC+A+N +GS
Sbjct: 327 TCRAQNPLGS 336
Score = 68.9 bits (167), Expect = 4e-11
Identities = 71/245 (28%), Positives = 99/245 (40%), Gaps = 42/245 (17%)
Query: 1048 NTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVW--------PGATVRE 1099
N L I A D G Y + G + +D +V+V PG T+
Sbjct: 111 NNCSLSIRDARKGDSGKYYFQVER--GSRKWNYIYDKLSVHVTALTHMPTFSIPG-TLES 167
Query: 1100 GQLVNLTCLV-WTTHPAQL-TYTWYQDGQQRLDA--------HSIPLPNVTVRDATSYRC 1149
G NLTC V W T TW LD IP P TS C
Sbjct: 168 GHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQ---DHGTSLTC 224
Query: 1150 GVGPPGRAPRLSRPITLDVLYAPRNLRLTYL---------------LESHGGQLALVLCT 1194
V PG ++R + L++ Y P+NL +T L GQ ++C
Sbjct: 225 QVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCA 284
Query: 1195 VDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSL 1254
VDS PPA+L+ + L+ S ++ N LEL +DEG ++C A++PLG + SL
Sbjct: 285 VDSNPPARLSWTWGSLTLSPSQSS---NLGVLELPRVHVKDEGEFTCRAQNPLGSQHISL 341
Query: 1255 ELRLE 1259
L L+
Sbjct: 342 SLSLQ 346
Score = 63.2 bits (152), Expect = 2e-09
Identities = 69/272 (25%), Positives = 98/272 (36%), Gaps = 49/272 (18%)
Query: 843 QVPSHGRFQ--AKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV 900
Q +HGRF + N+ L +R+ GDSG Y + GS + + V
Sbjct: 95 QEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVER--GSRKWNYIYDKLSVHVTA 152
Query: 901 -------SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLT 953
S L+ G L+C V +GT G + R + ++L
Sbjct: 153 LTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLI 212
Query: 954 QAGAYH-----CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL------ 1002
H CQ PG+ T A + L++SY P+++T+T G L
Sbjct: 213 PQPQDHGTSLTCQVTLPGAGVTMTRA-VRLNISYPPQNLTMTVFQGDGTASTTLRNGSAL 271
Query: 1003 ---------LLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLE 1053
L+C VDS+PPA+L G L S Q PR+HV
Sbjct: 272 SVLEGQSLHLVCAVDSNPPARLSWTWGS-LTLSPSQSSNLGVLELPRVHV---------- 320
Query: 1054 IHGAMLEDEGVYICEASNTLGQASASADFDAQ 1085
+DEG + C A N LG S Q
Sbjct: 321 ------KDEGEFTCRAQNPLGSQHISLSLSLQ 346
Score = 53.1 bits (126), Expect = 2e-06
Identities = 48/200 (24%), Positives = 79/200 (39%), Gaps = 34/200 (17%)
Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPL---ETVTLLPVARTDAALYA 773
TL+ G NLTC+V G+P +W V + ++L+P +
Sbjct: 164 TLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLT 223
Query: 774 CRI-LTEAGAQLSTPVLLSVLYPPDRPKLSAL---------------LDMGQGHMALFIC 817
C++ L AG ++ V L++ YPP ++ L + +G +C
Sbjct: 224 CQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVC 283
Query: 818 TVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCE 877
VDS P A L+ G L+ S +N LE+ + + D G + C
Sbjct: 284 AVDSNPPARLSWTWGSLTLSPS--------------QSSNLGVLELPRVHVKDEGEFTCR 329
Query: 878 ATNVLGSSNTSLFFQVRGAW 897
A N LGS + SL ++ +
Sbjct: 330 AQNPLGSQHISLSLSLQNEY 349
Score = 43.9 bits (102), Expect = 0.001
Identities = 40/133 (30%), Positives = 51/133 (38%), Gaps = 34/133 (25%)
Query: 1511 CLAELP-TGAAASAPVMLRVLYPPKTPTMMVFVEP--------EGGLRGILD-------C 1554
C LP G + V L + YPP+ TM VF G +L+ C
Sbjct: 224 CQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVC 283
Query: 1555 RVDSEPLASLTLHLGSRLVASSQPQ--GAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612
VDS P A L+ GS ++ SQ G P +HV D+GE+
Sbjct: 284 AVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHV----------------KDEGEFT 327
Query: 1613 CSASNVLGSASTS 1625
C A N LGS S
Sbjct: 328 CRAQNPLGSQHIS 340
Score = 41.2 bits (95), Expect = 0.009
Identities = 54/239 (22%), Positives = 90/239 (37%), Gaps = 40/239 (16%)
Query: 1222 NTLRLELRGPQPRDEGFYSCSARSPLGQANTSLE-LRLEGVRVILAPEAAVP----EGAP 1276
N L +R + D G Y + N + L + + P ++P G P
Sbjct: 111 NNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHP 170
Query: 1277 ITVTCADPAA---HAPTLYTWYHNGRWLQEGP---AASLSFLVATRAHAGAYSCQAQ-DA 1329
+TC+ P A P TW + ++ LS + + H + +CQ
Sbjct: 171 RNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPG 230
Query: 1330 QGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV---------------IQCTVDSEPP 1374
G +R L + Y PQ+ ++ F+ S + + C VDS PP
Sbjct: 231 AGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPP 290
Query: 1375 AELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGS 1433
A L+ + L+ S +S G +++ R+ V+D + + C AQN LGS
Sbjct: 291 ARLSWTWGSLTLSPSQ-----SSNLGVLELP----RVHVKD----EGEFTCRAQNPLGS 336
Score = 37.4 bits (85), Expect = 0.13
Identities = 63/266 (23%), Positives = 98/266 (36%), Gaps = 50/266 (18%)
Query: 467 GTSGPNSLRLEIRDLEETDSGEYKCSA---TNSLGNATSTLDFHANAARLL--ISPAAEV 521
G N+ L IRD + DSG+Y + L H A + S +
Sbjct: 106 GDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTL 165
Query: 522 VEGQ------AVTLSCRSGLSPTPDARFSWYLNGALLHEGPG---SSLLLPAASSTDAG- 571
G +V +C G PT +W + ++ P SS+L D G
Sbjct: 166 ESGHPRNLTCSVPWACEQGTPPT----ITW-MGASVSSLDPTITRSSMLSLIPQPQDHGT 220
Query: 572 SYHCRARDGHSASGPSSPAVLTVLYPPRQPTFT----------TRLDLDAAGAGAGRRGL 621
S C+ + + L + YPP+ T T T + A G+
Sbjct: 221 SLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLH 280
Query: 622 LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLL 681
L+C VDS+PPARL T G S + +++ NL +E+ +
Sbjct: 281 LVCAVDSNPPARLSW------------------TWG--SLTLSPSQSSNLGVLELPRVHV 320
Query: 682 EEEGLYLCEASNALGNASTSATFNGQ 707
++EG + C A N LG+ S + + Q
Sbjct: 321 KDEGEFTCRAQNPLGSQHISLSLSLQ 346
>gi|16506828 sialic acid binding immunoglobulin-like lectin-like
protein 1 isoform a precursor [Homo sapiens]
Length = 595
Score = 95.5 bits (236), Expect = 4e-19
Identities = 82/310 (26%), Positives = 135/310 (43%), Gaps = 33/310 (10%)
Query: 26 PQDVQGVKGSCLLIPCIFSFPA-DVEVPDGITAIWYY---DYSGQRQVVSHSADPKLVEA 81
P+ V +G C+ +PC +P + + W+ D V +++ K+ E
Sbjct: 156 PESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQED 215
Query: 82 RFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTL-VTVTEEPR 140
GR +G+P+ C+L ++D + DSG Y F+ E +W+ + L V VT
Sbjct: 216 T-HGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGS-RKWNYIYDKLSVHVTALTH 273
Query: 141 VPTIASPVELLEGTEVDFNCSTPYVCLQ-EQVRLQWQGQDPARSVTFNSQKFEPTGVGHL 199
+PT + P L G + CS P+ C Q + W G + +PT +
Sbjct: 274 MPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGA--------SVSSLDPT-ITRS 324
Query: 200 ETLHMAMSWQDHGRILRCQLSV--ANHRAQSEIHLQVKYAPKGVKI------------LL 245
L + QDHG L CQ+++ A + L + Y P+ + + L
Sbjct: 325 SMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLR 384
Query: 246 SPSGRNILPGELVTLTCQVNSSYPAVSSIKW--LKDGVRLQTKTGVLHLPQAAWSDAGVY 303
+ S ++L G+ + L C V+S+ PA S W L + GVL LP+ D G +
Sbjct: 385 NGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEF 444
Query: 304 TCQAENGVGS 313
TC+A+N +GS
Sbjct: 445 TCRAQNPLGS 454
Score = 68.9 bits (167), Expect = 4e-11
Identities = 71/245 (28%), Positives = 99/245 (40%), Gaps = 42/245 (17%)
Query: 1048 NTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVW--------PGATVRE 1099
N L I A D G Y + G + +D +V+V PG T+
Sbjct: 229 NNCSLSIRDARKGDSGKYYFQVER--GSRKWNYIYDKLSVHVTALTHMPTFSIPG-TLES 285
Query: 1100 GQLVNLTCLV-WTTHPAQL-TYTWYQDGQQRLDA--------HSIPLPNVTVRDATSYRC 1149
G NLTC V W T TW LD IP P TS C
Sbjct: 286 GHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQ---DHGTSLTC 342
Query: 1150 GVGPPGRAPRLSRPITLDVLYAPRNLRLTYL---------------LESHGGQLALVLCT 1194
V PG ++R + L++ Y P+NL +T L GQ ++C
Sbjct: 343 QVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCA 402
Query: 1195 VDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSL 1254
VDS PPA+L+ + L+ S ++ N LEL +DEG ++C A++PLG + SL
Sbjct: 403 VDSNPPARLSWTWGSLTLSPSQSS---NLGVLELPRVHVKDEGEFTCRAQNPLGSQHISL 459
Query: 1255 ELRLE 1259
L L+
Sbjct: 460 SLSLQ 464
Score = 63.2 bits (152), Expect = 2e-09
Identities = 69/272 (25%), Positives = 98/272 (36%), Gaps = 49/272 (18%)
Query: 843 QVPSHGRFQ--AKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV 900
Q +HGRF + N+ L +R+ GDSG Y + GS + + V
Sbjct: 213 QEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVER--GSRKWNYIYDKLSVHVTA 270
Query: 901 -------SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLT 953
S L+ G L+C V +GT G + R + ++L
Sbjct: 271 LTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLI 330
Query: 954 QAGAYH-----CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL------ 1002
H CQ PG+ T A + L++SY P+++T+T G L
Sbjct: 331 PQPQDHGTSLTCQVTLPGAGVTMTRA-VRLNISYPPQNLTMTVFQGDGTASTTLRNGSAL 389
Query: 1003 ---------LLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLE 1053
L+C VDS+PPA+L G L S Q PR+HV
Sbjct: 390 SVLEGQSLHLVCAVDSNPPARLSWTWGS-LTLSPSQSSNLGVLELPRVHV---------- 438
Query: 1054 IHGAMLEDEGVYICEASNTLGQASASADFDAQ 1085
+DEG + C A N LG S Q
Sbjct: 439 ------KDEGEFTCRAQNPLGSQHISLSLSLQ 464
Score = 57.4 bits (137), Expect = 1e-07
Identities = 95/447 (21%), Positives = 168/447 (37%), Gaps = 77/447 (17%)
Query: 18 QASWGVSSPQDVQGVKGSCLLIPCIFSFPADV-EVPDGITAIWYY--DYSGQRQVVSHSA 74
Q + ++ + V +G C+ + C FS+P + D + W+ D+ + V+ +
Sbjct: 21 QKDYLLTMQKSVTVQEGLCVSVLCSFSYPQNGWTASDPVHGYWFRAGDHVSRNIPVATNN 80
Query: 75 DPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWS---DVKGT 131
+ V+ R R +G+P+++ C L ++D + D+G+Y F E + +W+ D
Sbjct: 81 PARAVQEETRDRFHLLGDPQNKDCTLSIRDTRESDAGTYVFCVERGNM-KWNYKYDQLSV 139
Query: 132 LVTVTEEPRVP---TIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNS 188
VT +++ + V + EG V CS Y W P F
Sbjct: 140 NVTASQDLLSRYRLEVPESVTVQEGLCVSVPCSVLY------PHYNWTASSPVYGSWFKE 193
Query: 189 QKFEPTGVGHLETLHMAMSWQD-HGRIL--------RCQLSVANHRA--QSEIHLQVKYA 237
P + +D HGR L C LS+ + R + + QV+
Sbjct: 194 GADIPWDIPVATNTPSGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERG 253
Query: 238 PKGVKILLSPSGRNI----------LPGELVT-----LTCQV--NSSYPAVSSIKWLKDG 280
+ + ++ +PG L + LTC V +I W+
Sbjct: 254 SRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGAS 313
Query: 281 VR----LQTKTGVLHLPQAAWSDAGVYTCQAE-NGVG---------SLVSPP--ISLHIF 324
V T++ +L L TCQ G G ++ PP +++ +F
Sbjct: 314 VSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVF 373
Query: 325 MAEVQVS------PAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTL--- 375
+ S A +LE Q++ LVC + P+ L ++W + L + S L
Sbjct: 374 QGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTW--GSLTLSPSQSSNLGVL 431
Query: 376 ---RLHLATRADTGFYFCEVQNVHGSE 399
R+H+ D G + C QN GS+
Sbjct: 432 ELPRVHV---KDEGEFTCRAQNPLGSQ 455
Score = 53.1 bits (126), Expect = 2e-06
Identities = 48/200 (24%), Positives = 79/200 (39%), Gaps = 34/200 (17%)
Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPL---ETVTLLPVARTDAALYA 773
TL+ G NLTC+V G+P +W V + ++L+P +
Sbjct: 282 TLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLT 341
Query: 774 CRI-LTEAGAQLSTPVLLSVLYPPDRPKLSAL---------------LDMGQGHMALFIC 817
C++ L AG ++ V L++ YPP ++ L + +G +C
Sbjct: 342 CQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVC 401
Query: 818 TVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCE 877
VDS P A L+ G L+ S +N LE+ + + D G + C
Sbjct: 402 AVDSNPPARLSWTWGSLTLSPS--------------QSSNLGVLELPRVHVKDEGEFTCR 447
Query: 878 ATNVLGSSNTSLFFQVRGAW 897
A N LGS + SL ++ +
Sbjct: 448 AQNPLGSQHISLSLSLQNEY 467
Score = 43.9 bits (102), Expect = 0.001
Identities = 40/133 (30%), Positives = 51/133 (38%), Gaps = 34/133 (25%)
Query: 1511 CLAELP-TGAAASAPVMLRVLYPPKTPTMMVFVEP--------EGGLRGILD-------C 1554
C LP G + V L + YPP+ TM VF G +L+ C
Sbjct: 342 CQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVC 401
Query: 1555 RVDSEPLASLTLHLGSRLVASSQPQ--GAPAEPHIHVLASPNALRVDIEALRPSDQGEYI 1612
VDS P A L+ GS ++ SQ G P +HV D+GE+
Sbjct: 402 AVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHV----------------KDEGEFT 445
Query: 1613 CSASNVLGSASTS 1625
C A N LGS S
Sbjct: 446 CRAQNPLGSQHIS 458
Score = 41.2 bits (95), Expect = 0.009
Identities = 54/239 (22%), Positives = 90/239 (37%), Gaps = 40/239 (16%)
Query: 1222 NTLRLELRGPQPRDEGFYSCSARSPLGQANTSLE-LRLEGVRVILAPEAAVP----EGAP 1276
N L +R + D G Y + N + L + + P ++P G P
Sbjct: 229 NNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHP 288
Query: 1277 ITVTCADPAA---HAPTLYTWYHNGRWLQEGP---AASLSFLVATRAHAGAYSCQAQ-DA 1329
+TC+ P A P TW + ++ LS + + H + +CQ
Sbjct: 289 RNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPG 348
Query: 1330 QGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV---------------IQCTVDSEPP 1374
G +R L + Y PQ+ ++ F+ S + + C VDS PP
Sbjct: 349 AGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPP 408
Query: 1375 AELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGS 1433
A L+ + L+ S +S G +++ R+ V+D + + C AQN LGS
Sbjct: 409 ARLSWTWGSLTLSPSQ-----SSNLGVLELP----RVHVKD----EGEFTCRAQNPLGS 454
Score = 37.4 bits (85), Expect = 0.13
Identities = 63/266 (23%), Positives = 98/266 (36%), Gaps = 50/266 (18%)
Query: 467 GTSGPNSLRLEIRDLEETDSGEYKCSA---TNSLGNATSTLDFHANAARLL--ISPAAEV 521
G N+ L IRD + DSG+Y + L H A + S +
Sbjct: 224 GDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTL 283
Query: 522 VEGQ------AVTLSCRSGLSPTPDARFSWYLNGALLHEGPG---SSLLLPAASSTDAG- 571
G +V +C G PT +W + ++ P SS+L D G
Sbjct: 284 ESGHPRNLTCSVPWACEQGTPPT----ITW-MGASVSSLDPTITRSSMLSLIPQPQDHGT 338
Query: 572 SYHCRARDGHSASGPSSPAVLTVLYPPRQPTFT----------TRLDLDAAGAGAGRRGL 621
S C+ + + L + YPP+ T T T + A G+
Sbjct: 339 SLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLH 398
Query: 622 LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLL 681
L+C VDS+PPARL T G S + +++ NL +E+ +
Sbjct: 399 LVCAVDSNPPARLSW------------------TWG--SLTLSPSQSSNLGVLELPRVHV 438
Query: 682 EEEGLYLCEASNALGNASTSATFNGQ 707
++EG + C A N LG+ S + + Q
Sbjct: 439 KDEGEFTCRAQNPLGSQHISLSLSLQ 464
>gi|157694526 Fc receptor-like 5 [Homo sapiens]
Length = 977
Score = 92.8 bits (229), Expect = 3e-18
Identities = 199/821 (24%), Positives = 288/821 (35%), Gaps = 126/821 (15%)
Query: 200 ETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVT 259
ET + Q+ G RCQ S +HL A L+ + ++ G+ V
Sbjct: 69 ETPDNILEVQESGEY-RCQAQ--GSPLSSPVHLDFSSAS-----LILQAPLSVFEGDSVV 120
Query: 260 LTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPI 319
L C+ + ++I + + K H+P A D G Y C P+
Sbjct: 121 LRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKE----SCCPV 176
Query: 320 SLHIFMAEVQVSPAGPIL--------ENQTVTLVCNTP---NEAPSDLRYSWYKNHVLLE 368
S + +VQ P+L VTL C T + LR+ ++++ L
Sbjct: 177 SSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLG 236
Query: 369 DAHSHTLRLHLAT--RADTGFYFCEVQNVHGSERS-GPVS-VVVNHPPLTPVLTAFLETQ 424
S + + D+GFY+C+ + S S P S + V P PVLT E
Sbjct: 237 LGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKA 296
Query: 425 AGLVG---ILHCSVVSEPLATLV-LSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRD 480
G LHC + L TL H G L S + G S SL E
Sbjct: 297 LNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCER-----GASISFSLTTE--- 348
Query: 481 LEETDSGEYKCSATNSLGNATS---TLDFHANAARLLI---SPAAEVVEGQAVTLSCRSG 534
+SG Y C+A N LG S +L + ++ SP + EG VTL C +
Sbjct: 349 ----NSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQ 404
Query: 535 LSPTPDARFSWYLNGALLH----EGPGSSLLLPAASSTDAGSYHCRARDGHSASGP--SS 588
P + ++ GA L G + + ++ +G+Y+C A +G GP S
Sbjct: 405 RGSLP-ILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGF---GPQRSK 460
Query: 589 PAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARL-QLLHKDRVVATSL 647
L+V P P T L A G L C V P L Q H+D + +S
Sbjct: 461 AVSLSVTVPVSHPVLT--LSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSS- 517
Query: 648 PSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLE-EEGLYLCEASNALGNASTSATFNG 706
P++ RV L E G Y C A N G S +
Sbjct: 518 -------------------STPSVGRVSFSFSLTEGHSGNYYCTADNGFG-PQRSEVVSL 557
Query: 707 QATVLAIAPSHTLQ-------EGTEANLTCNVSREAAGSPANFSWFRN-----GVLWAQG 754
TV P TL+ G L C R GSP WF + G A
Sbjct: 558 FVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPR---GSPPILYWFYHEDVTLGSSSAPS 614
Query: 755 PLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQ---GH 811
E L + + Y+C AQ S + LSV+ P RP L+ Q G
Sbjct: 615 GGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGD 674
Query: 812 MALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDS 871
+ C +L F+ E + + PS G + +L L S
Sbjct: 675 LLELHCEALRGSSPILYWFYHEDVTLGKI--SAPSGG-----GASFNLSLTTEH-----S 722
Query: 872 GSYRCEATNVLGSSNTSLFF------QVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEG 925
G Y CEA N L + + + R +P G + L C+ G P
Sbjct: 723 GIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPL- 781
Query: 926 TSYRWYRD----GQPLQESTSATLRFAAITLTQAGAYHCQA 962
YR++ + G S A+L ++T +G Y C+A
Sbjct: 782 ILYRFFHEDVTLGNRSSPSGGASLNL-SLTAEHSGNYSCEA 821
Score = 92.0 bits (227), Expect = 4e-18
Identities = 162/685 (23%), Positives = 251/685 (36%), Gaps = 95/685 (13%)
Query: 99 NLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIA-SPVELL--EGTE 155
N + + +DSG Y + + SD + + V P + SP + L EGT+
Sbjct: 244 NFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTK 303
Query: 156 VDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRIL 215
V +C T L+ R +G P R + ++ ++ +++ ++ G
Sbjct: 304 VTLHCETQEDSLRTLYRFYHEGV-PLRHKSVRCERGA--------SISFSLTTENSGNYY 354
Query: 216 RCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVN-SSYPAVSSI 274
+ + + L V + LS I G VTL C+ S P +
Sbjct: 355 CTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPIL--Y 412
Query: 275 KWLKDGVRLQTKT-----GVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQ 329
++ +G L+ ++ GV +G Y C A+NG G S +SL V
Sbjct: 413 QFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSL-----SVT 467
Query: 330 VSPAGPIL----------ENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHL 379
V + P+L E TVTL C +P L ++++ L + R+
Sbjct: 468 VPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSF 527
Query: 380 A---TRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVG---ILHC 433
+ T +G Y+C N G +RS VS+ V P P+LT + +VG LHC
Sbjct: 528 SFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHC 587
Query: 434 SVV-SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCS 492
P H L S+S S F+ L SG Y C
Sbjct: 588 EAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFN------------LSLTAEHSGNYSCE 635
Query: 493 ATNSL---GNATSTLDFHANAARLLI---SPAAEVVEGQAVTLSCRSGLSPTPDARFSWY 546
A N L + T +L +R ++ +P A+ V G + L C + +P + ++
Sbjct: 636 ANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYH 695
Query: 547 ----LNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPT 602
L G G+S L + ++ +G Y C A +G A S L V P +P
Sbjct: 696 EDVTLGKISAPSGGGASFNL-SLTTEHSGIYSCEADNGLEAQ-RSEMVTLKVAVPVSRPV 753
Query: 603 FTTRLDLDAAGAGAGRRGLLLCRVDS---DPPARLQLLHKDRVVATSLPSGGGCSTCGGC 659
T R A G A LL ++ P + H+D + G S GG
Sbjct: 754 LTLR----APGTHAAVGDLLELHCEALRGSPLILYRFFHED------VTLGNRSSPSGGA 803
Query: 660 SPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTL 719
S + +T E G Y CEA N LG A S T T L S
Sbjct: 804 SLNLSLT--------------AEHSGNYSCEADNGLG-AQRSETVTLYITGLTANRSGPF 848
Query: 720 QEGTEANLTCNVSREAAGSPANFSW 744
G L +++ AAG+ + W
Sbjct: 849 ATGVAGGL-LSIAGLAAGALLLYCW 872
Score = 85.9 bits (211), Expect = 3e-16
Identities = 216/888 (24%), Positives = 310/888 (34%), Gaps = 142/888 (15%)
Query: 243 ILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW----LKDGVRLQTKTGVLHLPQAAWS 298
I L P + GE VTLTC+ Y + KW L + +T +L +
Sbjct: 25 IFLQPPWTTVFQGERVTLTCKGFRFY-SPQKTKWYHRYLGKEILRETPDNILEV-----Q 78
Query: 299 DAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRY 358
++G Y CQA+ GS +S P+ L A + + + E +V L C +A L
Sbjct: 79 ESGEYRCQAQ---GSPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRA--KAEVTLNN 133
Query: 359 SWYKNHVLLEDAHSHT-LRLHLATRADTGFYFCE-VQNVHGSERSGPVSVVVNHPPLTPV 416
+ YKN +L + T + A D G Y C + S V + V P PV
Sbjct: 134 TIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPV 193
Query: 417 LTA-FLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLR 475
L A + +G L C L L L D + + PN
Sbjct: 194 LRASSFQPISGNPVTLTCE------TQLSLERSDVPLRFRFFRDDQTLGLGWSLSPN--- 244
Query: 476 LEIRDLEETDSGEYKCSATNSLGNATS-------TLDFHANAARLLISPAAEV-VEGQAV 527
+I + DSG Y C A + S + A+ L +SP + EG V
Sbjct: 245 FQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKV 304
Query: 528 TLSCRSGLSPTPDARFSWYLNGA-LLHEG----PGSSLLLPAASSTDAGSYHCRARDGHS 582
TL C + + + +Y G L H+ G+S+ + ++ ++G+Y+C A +G
Sbjct: 305 TLHCET-QEDSLRTLYRFYHEGVPLRHKSVRCERGASISF-SLTTENSGNYYCTADNGLG 362
Query: 583 ASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVD-SDPPARLQLLHKDR 641
A PS L+V P P D GA + L C P Q H+
Sbjct: 363 AK-PSKAVSLSVTVPVSHPVLNLSSPEDLIFEGA--KVTLHCEAQRGSLPILYQFHHEGA 419
Query: 642 VVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALG----- 696
+ ++ GG + +T E G Y C A N G
Sbjct: 420 ALERR-----SANSAGGVAISFSLT--------------AEHSGNYYCTADNGFGPQRSK 460
Query: 697 NASTSATFNGQATVLAIAPSHTLQ-EGTEANLTCNVSREAAGSPANFSWF--RNGVLWAQ 753
S S T VL ++ + L EG L C V R GSP F + LW+
Sbjct: 461 AVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQR---GSPQILYQFYHEDMPLWSS 517
Query: 754 GPLETVTL---LPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQ- 809
+ + + Y C G Q S V L V P RP L+ + Q
Sbjct: 518 STPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQA 577
Query: 810 --GHMALFICTVD-SRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEAN-SLKLEVRE 865
G + C P L +H + L +S PS G +A N SL E
Sbjct: 578 VVGDLLELHCEAPRGSPPILYWFYHEDVTLGSS---SAPSGG----EASFNLSLTAE--- 627
Query: 866 LGLGDSGSYRCEATNVL---GSSNTSLFFQV---RGAWVQVSPSPELQEGQAVVLSCQVH 919
SG+Y CEA N L S SL V R +P + G + L C+
Sbjct: 628 ----HSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEAL 683
Query: 920 TGVPEGTSYRWYRD---GQPLQESTSATLRFAAITLTQAGAYHC------QAQAPGSATT 970
G + ++ D G+ S ++T +G Y C +AQ T
Sbjct: 684 RGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTL 743
Query: 971 SLAAPIS---LHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQL-RLLHGDRLVAS 1026
+A P+S L + H + L++ L C P L R H D
Sbjct: 744 KVAVPVSRPVLTLRAPGTHAAVGDLLE--------LHCEALRGSPLILYRFFHED----V 791
Query: 1027 TLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLG 1074
TL P G + +L L + E G Y CEA N LG
Sbjct: 792 TLGNRSSPSGGA----------SLNLSL---TAEHSGNYSCEADNGLG 826
Score = 80.9 bits (198), Expect = 1e-14
Identities = 178/698 (25%), Positives = 246/698 (35%), Gaps = 114/698 (16%)
Query: 244 LLSPSGRNILPGELVTLTCQVNSSYPAVS---SIKWLKDGVRLQTKTGVLHLPQ--AAWS 298
+L S + G VTLTC+ S ++ +D L + Q A WS
Sbjct: 193 VLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWS 252
Query: 299 -DAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPIL----------ENQTVTLVCN 347
D+G Y C+A S++S I +VQ+ + P+L E VTL C
Sbjct: 253 KDSGFYWCKAATMPYSVISDSPRSWI---QVQIPASHPVLTLSPEKALNFEGTKVTLHCE 309
Query: 348 TPNEAPSDLRYSWYKNHVLLEDAHSHTLR----LHLATRADTGFYFCEVQNVHGSERSGP 403
T ++ L Y +Y V L R T ++G Y+C N G++ S
Sbjct: 310 TQEDSLRTL-YRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKA 368
Query: 404 VSVVVNHPPLTPVLTAFLETQAGLVGI---LHCSVVSEPLATLV-LSHGGHILASTSGDS 459
VS+ V P PVL G LHC L L H G L S +S
Sbjct: 369 VSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANS 428
Query: 460 DHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATS-----TLDFHANAARLL 514
G + SL E SG Y C+A N G S ++ + L
Sbjct: 429 A-----GGVAISFSLTAE-------HSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLT 476
Query: 515 ISPA-AEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEG--PGSSLLLPAASSTD-- 569
+S A A EG VTL C +P + +Y L P + + S T+
Sbjct: 477 LSSAEALTFEGATVTLHCEVQRG-SPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGH 535
Query: 570 AGSYHCRARDGHSASGPSSPAVLT--VLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVD 627
+G+Y+C A +G GP V++ V P +P T R+ A A G L C
Sbjct: 536 SGNYYCTADNGF---GPQRSEVVSLFVTVPVSRPILTLRVP--RAQAVVGDLLELHCEAP 590
Query: 628 -SDPPARLQLLHKDRVV-ATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685
PP H+D + ++S PSGG S + +T E G
Sbjct: 591 RGSPPILYWFYHEDVTLGSSSAPSGGEASF------NLSLTA--------------EHSG 630
Query: 686 LYLCEASNALGNASTSATFNGQATVLAIAPSHTLQE-------GTEANLTCNVSREAAGS 738
Y CEA+N L A S T + V P T + G L C R GS
Sbjct: 631 NYSCEANNGLV-AQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALR---GS 686
Query: 739 PANFSWFRN-----GVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVL 793
WF + G + A L + + +Y+C AQ S V L V
Sbjct: 687 SPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVA 746
Query: 794 YPPDRPKLSALLD---MGQGHMALFIC-TVDSRPLALLALFHGEHLLATSLGPQVPSHGR 849
P RP L+ G + C + PL L FH + L P +
Sbjct: 747 VPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPSGGASLN 806
Query: 850 FQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNT 887
AE SG+Y CEA N LG+ +
Sbjct: 807 LSLTAE--------------HSGNYSCEADNGLGAQRS 830
Score = 74.7 bits (182), Expect = 7e-13
Identities = 206/884 (23%), Positives = 314/884 (35%), Gaps = 162/884 (18%)
Query: 866 LGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEG 925
L + +SG YRC+A SS L F +Q S + EG +VVL C+ V
Sbjct: 75 LEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLS--VFEGDSVVLRCRAKAEVTLN 132
Query: 926 TSYRWYRDGQPLQESTSAT-LRFAAITLTQAGAYHC----QAQAPGSATT-------SLA 973
+ Y++ L T L GAY C ++ P S+ T
Sbjct: 133 NTI--YKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFT 190
Query: 974 APISLHVSYAP---RHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQG 1030
P+ S+ P VTLT R SD P + R D+ + G
Sbjct: 191 RPVLRASSFQPISGNPVTLTCETQLSLER---------SDVPLRFRFFRDDQTL-----G 236
Query: 1031 VGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQ 1090
+G +++PN +I +D G Y C+A+ S +D + VQ
Sbjct: 237 LGW----------SLSPN---FQITAMWSKDSGFYWCKAATM--PYSVISDSPRSWIQVQ 281
Query: 1091 V---WPGATVREGQLVNLTCLVWTTH------PAQLTYTWYQDG------QQRLDAHSIP 1135
+ P T+ + +N T H + Y +Y +G R + +
Sbjct: 282 IPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASI 341
Query: 1136 LPNVTVRDATSYRC----GVGP-PGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLAL 1190
++T ++ +Y C G+G P +A LS +T+ V + NL L G ++ L
Sbjct: 342 SFSLTTENSGNYYCTADNGLGAKPSKAVSLS--VTVPVSHPVLNLSSPEDLIFEGAKVTL 399
Query: 1191 VLCTVDSRPPAQLALSHAGRLLASSTAASVPNT-LRLELRGPQPRDEGFYSCSARSPLG- 1248
P H G L +A S + L G Y C+A + G
Sbjct: 400 HCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEH---SGNYYCTADNGFGP 456
Query: 1249 QANTSLELRL-----EGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGR--WL 1301
Q + ++ L + V + + EA EGA +T+ C LY +YH W
Sbjct: 457 QRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWS 516
Query: 1302 QEGPAA---SLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSR 1358
P+ S SF + T H+G Y C A + G + S +L V P + + R R
Sbjct: 517 SSTPSVGRVSFSFSL-TEGHSGNYYCTADNGFGPQRSEVVSLFVT-VPVSRPILTLRVPR 574
Query: 1359 ARSMA----VIQCTVD-SEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQV 1413
A+++ + C PP H+ L +SS SG + L +
Sbjct: 575 AQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSA----PSG------GEASFNLSL 624
Query: 1414 QDVPAGDDTYVCTAQN-LLGSISTIGRLQV-----EGARVVAEPGLDVPEGAALNLSCRL 1467
+G+ Y C A N L+ S L V P G L L C
Sbjct: 625 TAEHSGN--YSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEA 682
Query: 1468 LGGPGPVGNSTFAWFWNDR----RLHAEPVPTLAFT-HVARAQAGMYHCLAELPTGAAAS 1522
L G P+ WF+++ ++ A +F + +G+Y C A+ A S
Sbjct: 683 LRGSSPI----LYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRS 738
Query: 1523 APVMLRVLYPPKTPTMMVFVEPEGGLRG-ILDCRVDSEPLASLTLH--------LGSRLV 1573
V L+V P P + + G +L+ ++ + L L+ LG+R
Sbjct: 739 EMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNR-- 796
Query: 1574 ASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTST---YFGV 1630
S P G AS N +L G Y C A N LG+ + T Y
Sbjct: 797 --SSPSGG---------ASLNL------SLTAEHSGNYSCEADNGLGAQRSETVTLYITG 839
Query: 1631 RALHRLHQFQQ-----LLWVLGLLVGLLLLLLGLGACYTWRRRR 1669
+R F LL + GL G LLL Y W R+
Sbjct: 840 LTANRSGPFATGVAGGLLSIAGLAAGALLL-------YCWLSRK 876
Score = 32.7 bits (73), Expect = 3.1
Identities = 29/121 (23%), Positives = 48/121 (39%), Gaps = 7/121 (5%)
Query: 1267 PEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQA 1326
P V +G +T+TC ++P WYH R+L + + +G Y CQ
Sbjct: 30 PWTTVFQGERVTLTCKGFRFYSPQKTKWYH--RYLGKEILRETPDNILEVQESGEYRCQ- 86
Query: 1327 QDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVL 1386
AQG+ S P L ++ +L + V++C +E + + VL
Sbjct: 87 --AQGSPLSSPVHLD--FSSASLILQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVL 142
Query: 1387 A 1387
A
Sbjct: 143 A 143
>gi|15147240 brother of CDO [Homo sapiens]
Length = 1114
Score = 92.0 bits (227), Expect = 4e-18
Identities = 109/395 (27%), Positives = 166/395 (42%), Gaps = 60/395 (15%)
Query: 898 VQVSPSPELQE-GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQES--------TSATLRFA 948
V V P+ +Q+ G V+L C V P + W +G+ L S T TL
Sbjct: 38 VTVQPASTVQKPGGTVILGCVVE---PPRMNVTWRLNGKELNGSDDALGVLITHGTLVIT 94
Query: 949 AITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRV- 1007
A+ G Y C A+ P A S+ A ++L + + + +++ G ++ C +
Sbjct: 95 ALNNHTVGRYQCVARMPAGAVASVPATVTL-ANLQDFKLDVQHVIEVDEGNTAVIACHLP 153
Query: 1008 DSDPPAQLRL-LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYI 1066
+S P AQ+R + + L AS + P G+ L+I A EDEG+Y
Sbjct: 154 ESHPKAQVRYSVKQEWLEASRGNYLIMPSGN--------------LQIVNASQEDEGMYK 199
Query: 1067 CEASNTLGQ---ASASAD------FDAQAVNVQVWPGAT---VREGQLVNLTCLVWTTHP 1114
C A N + Q S S+D A+A + P A V +GQ + L C+ P
Sbjct: 200 CAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPP 259
Query: 1115 AQLTYTWYQDGQQ-------RLDAHSIPLPNVTVRDATSYRC----GVGPPGRAPRLSRP 1163
++T W +DG R ++ + + D+ +YRC GVG PG A L
Sbjct: 260 PRVT--WAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVIL--- 314
Query: 1164 ITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQ-LALSHAGRLLASSTAASVPN 1222
+ V P L GQ A + C V PP L L +A L++S
Sbjct: 315 YNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRR 374
Query: 1223 TLRLELRGPQPRDEGFYSCSARSPLGQANTSLELR 1257
LR+ GP+ DEG Y C A + +G A+ ++LR
Sbjct: 375 ALRVLSMGPE--DEGVYQCMAENEVGSAHAVVQLR 407
Score = 68.6 bits (166), Expect = 5e-11
Identities = 121/507 (23%), Positives = 201/507 (39%), Gaps = 69/507 (13%)
Query: 1073 LGQASASADFDAQAVNVQVWPGATVRE-GQLVNLTCLVWTTHPAQLTYTWYQDGQQRL-- 1129
L A AD + + V V P +TV++ G V L C+V P ++ TW +G++
Sbjct: 23 LATAGCFADLN-EVPQVTVQPASTVQKPGGTVILGCVV---EPPRMNVTWRLNGKELNGS 78
Query: 1130 -DAHSIPLPNVTV-------RDATSYRCGVG-PPGRAPRLSRPITLDVLYAPRNLRLTYL 1180
DA + + + T+ Y+C P G + +TL L + L + ++
Sbjct: 79 DDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFK-LDVQHV 137
Query: 1181 LESHGGQLALVLCTV-DSRPPAQLALSHAGRLLASSTAAS-VPNTLRLELRGPQPRDEGF 1238
+E G A++ C + +S P AQ+ S L +S + + L++ DEG
Sbjct: 138 IEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGM 197
Query: 1239 YSCSARSPLGQ----ANTSLELRL-----EGVRVILAPEAA---VPEGAPITVTCADPAA 1286
Y C+A +P+ Q + +S LR+ E R+I PEA V +G + + C
Sbjct: 198 YKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGI 257
Query: 1287 HAPTLYTW---------YHNGRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRP 1337
P + TW Y+ R+L ++L + +G Y C A + G +P
Sbjct: 258 PPPRV-TWAKDGSSVTGYNKTRFL----LSNLLIDTTSEEDSGTYRCMADNGVG----QP 308
Query: 1338 AALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLAS 1397
A +LY Q V + S VI ++ E+ + VL + V ++S
Sbjct: 309 GAAVILYNVQ--VFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISS 366
Query: 1398 GTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPE 1457
++++R ALR+ P + Y C A+N +GS + +L+ + D
Sbjct: 367 Q--RLRLSRRALRVLSMG-PEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQD--- 420
Query: 1458 GAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPT 1517
L G PV S ++ L +P T V A C E
Sbjct: 421 -------AELATGTPPVSPSKLG--NPEQMLRGQPALPRPPTSVGPASP---QCPGEKGQ 468
Query: 1518 GAAASAPVMLRVLYPPKTPTMMVFVEP 1544
GA A AP++L KT + + P
Sbjct: 469 GAPAEAPIILSSPRTSKTDSYELVWRP 495
Score = 65.5 bits (158), Expect = 4e-10
Identities = 98/400 (24%), Positives = 157/400 (39%), Gaps = 64/400 (16%)
Query: 327 EVQVSPAGPILE-NQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH--------TLRL 377
+V V PA + + TV L C P + +W N L + TL +
Sbjct: 37 QVTVQPASTVQKPGGTVILGCVVE---PPRMNVTWRLNGKELNGSDDALGVLITHGTLVI 93
Query: 378 HLATRADTGFYFCEVQNVHGSERSGPVSVVV-NHPPLTPVLTAFLETQAGLVGILHCSVV 436
G Y C + G+ S P +V + N + +E G ++ C +
Sbjct: 94 TALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLP 153
Query: 437 -SEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATN 495
S P A + S L ++ G+ P S L+I + + D G YKC+A N
Sbjct: 154 ESHPKAQVRYSVKQEWLEASRGNYLIMP---------SGNLQIVNASQEDEGMYKCAAYN 204
Query: 496 SLGNATSTLDFH---------ANAARLLISPAAE---VVEGQAVTLSCRSGLSPTPDARF 543
+ T A AAR++ P A+ V +GQ++ L C + P P R
Sbjct: 205 PVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPP--RV 262
Query: 544 SWYLNGALLHEGPG-----SSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
+W +G+ + S+LL+ S D+G+Y C A +G G + ++ P
Sbjct: 263 TWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEP 322
Query: 599 RQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGG 658
+ T ++L G+ L C V +PP + L A L S
Sbjct: 323 PEVT----MELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRN----AVPLIS--------- 365
Query: 659 CSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNA 698
S R+++++ LRV P E+EG+Y C A N +G+A
Sbjct: 366 -SQRLRLSR--RALRVLSMGP--EDEGVYQCMAENEVGSA 400
Score = 54.3 bits (129), Expect = 1e-06
Identities = 94/366 (25%), Positives = 145/366 (39%), Gaps = 68/366 (18%)
Query: 1293 TWYHNGRWLQEGPAASLSFLV--------ATRAHA-GAYSCQAQDAQGTRSSRPAALQVL 1343
TW NG+ L G +L L+ A H G Y C A+ G +S PA + +
Sbjct: 67 TWRLNGKELN-GSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTL- 124
Query: 1344 YAPQDAVLSSFR-------DSRARSMAVIQCTV-DSEPPAELALSHDGKVLATSSGVHSL 1395
A L F+ + + AVI C + +S P A++ S + L S G + L
Sbjct: 125 -----ANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNY-L 178
Query: 1396 ASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQN-LLGSISTIG---RLQV-----EGAR 1446
+G++Q+ V + Y C A N + + T G RL+V E AR
Sbjct: 179 IMPSGNLQI--------VNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAAR 230
Query: 1447 VVAEPGLD---VPEGAALNLSCRLLGGPGP-----VGNSTFAWFWNDRRLHAEPVPTLAF 1498
++ P V +G +L L C G P P S+ + R L + L
Sbjct: 231 IIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFL----LSNLLI 286
Query: 1499 THVARAQAGMYHCLAELPTGAAASAPVM--LRVLYPPKTPTMMVFVEPEGGLRGILDCRV 1556
+ +G Y C+A+ G +A ++ ++V PP+ + + G L C V
Sbjct: 287 DTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEV 346
Query: 1557 DSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSAS 1616
P S+ + + SSQ + S ALRV ++ P D+G Y C A
Sbjct: 347 RGNPPPSVLWLRNAVPLISSQ----------RLRLSRRALRV--LSMGPEDEGVYQCMAE 394
Query: 1617 NVLGSA 1622
N +GSA
Sbjct: 395 NEVGSA 400
Score = 43.1 bits (100), Expect = 0.002
Identities = 76/324 (23%), Positives = 127/324 (39%), Gaps = 42/324 (12%)
Query: 49 VEVPDGITAI--WYYDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQ 106
+EV +G TA+ + S + V +S + +EA RG M + ++ N +D
Sbjct: 138 IEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEAS-RGNYLIMPSGNLQIVNASQEDEG 196
Query: 107 PEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRV--PTIASPVELLEGTEVDFNCSTPY 164
+YN + + + SD + E R+ P A + + +G + C
Sbjct: 197 MYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASG 256
Query: 165 VCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLS--VA 222
+ R+ W +D + +N +F L L + + ++ RC V
Sbjct: 257 I---PPPRVTW-AKDGSSVTGYNKTRFL------LSNLLIDTTSEEDSGTYRCMADNGVG 306
Query: 223 NHRAQSEIHLQVKYAPKGVKILLSPSGRNILP-GELVTLTCQVNSSYPAVSSIKWLKDGV 281
A ++ + P V + LS + ++P G+ LTC+V + P S+ WL++ V
Sbjct: 307 QPGAAVILYNVQVFEPPEVTMELS---QLVIPWGQSAKLTCEVRGNPPP--SVLWLRNAV 361
Query: 282 ------RLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGP 335
RL+ L + D GVY C AEN VGS A VQ+ + P
Sbjct: 362 PLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSA----------HAVVQLRTSRP 411
Query: 336 ILEN---QTVTLVCNTPNEAPSDL 356
+ Q L TP +PS L
Sbjct: 412 SITPRLWQDAELATGTPPVSPSKL 435
Score = 39.3 bits (90), Expect = 0.033
Identities = 91/417 (21%), Positives = 148/417 (35%), Gaps = 63/417 (15%)
Query: 255 GELVTLTCQVNSSYPAVS---SIK--WLKD--GVRLQTKTGVLHLPQAAWSDAGVYTCQA 307
G + C + S+P S+K WL+ G L +G L + A+ D G+Y C A
Sbjct: 143 GNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAA 202
Query: 308 ENGVGSLVSPPISLHIFMAEVQVSPAGPIL-----------ENQTVTLVCNTPNEAPSDL 356
N V V S + A I+ + Q++ L C P
Sbjct: 203 YNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPP-- 260
Query: 357 RYSWYKNHVLLEDAHS-----HTLRLHLATRADTGFYFCEVQNVHGSERSGPV--SVVVN 409
R +W K+ + + L + + D+G Y C N G + + +V V
Sbjct: 261 RVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVF 320
Query: 410 HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTS 469
PP + + L G L C V P +++ L S+ R S +
Sbjct: 321 EPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQ-----RLRLSRRA 375
Query: 470 GPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPA----AEVVEGQ 525
L + + D G Y+C A N +G+A + + +R I+P AE+ G
Sbjct: 376 ------LRVLSMGPEDEGVYQCMAENEVGSAHAVVQL--RTSRPSITPRLWQDAELATGT 427
Query: 526 AVTLSCRSGLSPTPDARFSWYLNGALLHEGPGS---------------SLLLPAASSTDA 570
+ G +P R L GP S ++L + ++
Sbjct: 428 PPVSPSKLG-NPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKT 486
Query: 571 GSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVD 627
SY R H SG + +L + R+ T ++ D +G A + L L R+D
Sbjct: 487 DSYELVWRPRHEGSGRA--PILYYVVKHRKVTNSSD-DWTISGIPANQHRLTLTRLD 540
Score = 38.1 bits (87), Expect = 0.074
Identities = 92/429 (21%), Positives = 159/429 (37%), Gaps = 88/429 (20%)
Query: 512 RLLISPAAEVVE-GQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGS--------SLLL 562
++ + PA+ V + G V L C + P +W LNG L+ + +L++
Sbjct: 37 QVTVQPASTVQKPGGTVILGC---VVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVI 93
Query: 563 PAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLD-AAGAGAGRRGL 621
A ++ G Y C AR A S PA +T+ +LD+ G +
Sbjct: 94 TALNNHTVGRYQCVARMPAGAVA-SVPATVTLANLQ-----DFKLDVQHVIEVDEGNTAV 147
Query: 622 LLCRV-DSDPPARLQLLHKDRVVATS------LPSGGGCSTCGGCSPRMKVTKAPNLLRV 674
+ C + +S P A+++ K + S +PSG +
Sbjct: 148 IACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGN----------------------L 185
Query: 675 EIHNPLLEEEGLYLCEASNAL-------GNASTSATFNGQATVLAI-----APSHTLQEG 722
+I N E+EG+Y C A N + G++ A I A + + +G
Sbjct: 186 QIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKG 245
Query: 723 TEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLP------VARTDAALYACRI 776
L C S P +W ++G G +T LL + D+ Y C
Sbjct: 246 QSLILECVAS---GIPPPRVTWAKDGSS-VTGYNKTRFLLSNLLIDTTSEEDSGTYRCMA 301
Query: 777 LTEAGAQLSTPVL--LSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPL-ALLALFHGE 833
G + +L + V PP+ + L + G A C V P ++L L +
Sbjct: 302 DNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAV 361
Query: 834 HLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQV 893
L+++ + + L V +G D G Y+C A N +GS++ + Q+
Sbjct: 362 PLISSQ-------------RLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVV--QL 406
Query: 894 RGAWVQVSP 902
R + ++P
Sbjct: 407 RTSRPSITP 415
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 91.7 bits (226), Expect = 6e-18
Identities = 150/617 (24%), Positives = 234/617 (37%), Gaps = 86/617 (13%)
Query: 903 SPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQ-----AGA 957
S E+ G V L C +G P + RW +DG+PL + T R +T++ +G
Sbjct: 294 SQEVWAGHTVELPCTA-SGYPI-PAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSGT 351
Query: 958 YHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTL-MDTGPGRLGLLLCRVDSDPPAQLR 1016
Y C+ + T A + + P HVTLT + TG G +L C + P +R
Sbjct: 352 YICEV----TNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIR 407
Query: 1017 LLHGDRLV----ASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNT 1072
LV A +++G+ L I A G Y C A+
Sbjct: 408 WYRNTELVLPDEAISIRGLSNET----------------LLITSAQKSHSGAYQCFATR- 450
Query: 1073 LGQASASADFDAQAVN------VQVWPGATVREGQLVNLTCLVWTTHPAQLTYTW----- 1121
+A + DF A+ V + V G+ +L C P +T+
Sbjct: 451 --KAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI 508
Query: 1122 YQDGQQRL------DAHSIPLPNVT---VRDATSYRCG----VGPPGRAPRLSRPITLDV 1168
+DG R D +I NVT +RD YRC VG R++
Sbjct: 509 VRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARIN------- 561
Query: 1169 LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLEL 1228
+ P ++R + + G+ L+ C V P + LL + V L+L
Sbjct: 562 VRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKL 621
Query: 1229 RGPQP-RDEGFYSCSAR-SPLGQANTSLELRLEGVRVILAPEAAVPE--GAPITVTCADP 1284
Q DEG Y CS P + S+ + ++ V ++ P P G + + C
Sbjct: 622 TDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVK-VPPLIQPFEFPPASIGQLLYIPCVVS 680
Query: 1285 AAHAPTLYTWYHNGRWLQEGPA---------ASLSFLVATRAHAGAYSCQAQDAQGTRSS 1335
+ P TW +G+ + G +SL + H G Y+C A +A T S
Sbjct: 681 SGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAAT-VS 739
Query: 1336 RPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSL 1395
R L V P+ V + +D V+ C+VD PP ++ H K H +
Sbjct: 740 RERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKH-AKGSGNPQQYHPV 798
Query: 1396 ASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGS-ISTIGRLQVE-GARVVAEPGL 1453
TG +Q+ N+ L + Y+C A N +G+ IS L V+ A + + P
Sbjct: 799 PL-TGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNT 857
Query: 1454 DVP-EGAALNLSCRLLG 1469
+ +G A L+C G
Sbjct: 858 TIAIKGHAKELNCTARG 874
Score = 85.1 bits (209), Expect = 5e-16
Identities = 164/778 (21%), Positives = 283/778 (36%), Gaps = 105/778 (13%)
Query: 303 YTCQAENGVGSLVSPPISLHIFMAE---VQVSPAGPILENQTVTLVCNTPNEAPSDLRY- 358
Y C AEN G + SP I + E V+V + N V C P+ +
Sbjct: 161 YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAV-FKCLIPSSVQEYVSVV 219
Query: 359 SWYKNHVLLEDAHSHTLRLH-------LATRADTGFYFCEVQNVHGSE--RSGPVSVVVN 409
SW K+ V + H + H + Y C ++ + E +S + V
Sbjct: 220 SWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVT 279
Query: 410 HPP--LTPVLTAF--LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRF 465
P + +L F E AG L C+ P+ + G L + DS + R
Sbjct: 280 DPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPA---DSRWTKRI 336
Query: 466 SGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATST-LDFHANAARLLISP-AAEVVE 523
+G L I DL DSG Y C TN+ G+A +T + + + ++P +
Sbjct: 337 TG--------LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGI 388
Query: 524 GQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSS--------LLLPAASSTDAGSYHC 575
G V LSC L+ +P+ WY N L+ S LL+ +A + +G+Y C
Sbjct: 389 GSTVILSC--ALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQC 446
Query: 576 RARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635
A + + L P +F+ ++ G + L+C PP +
Sbjct: 447 FATRKAQTAQDFAIIALEDGTPRIVSSFSEKV------VNPGEQFSLMCAAKGAPPPTVT 500
Query: 636 LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695
D + G T + ++ + + + P + + G+Y C A N +
Sbjct: 501 WALDDEPIVRD----GSHRT-----NQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLV 551
Query: 696 GNASTSATFN--GQATVLAIAPSHTLQEGTEANLTCNVSREAAGSP-ANFSWFRNGVLWA 752
G+A A N G ++ A+ + T G + + C V G P + W+++ +L
Sbjct: 552 GSAEYQARINVRGPPSIRAMR-NITAVAGRDTLINCRV----IGYPYYSIKWYKDALLLP 606
Query: 753 QGPLE------TVTLLPVAR-TDAALYACRILTEAGAQLSTPVLLSVLYPP-----DRPK 800
+ T+ L V + D Y C +L + +S V ++V PP + P
Sbjct: 607 DNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPP 666
Query: 801 LSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLK 860
S G + C V S + + + + G + S +++
Sbjct: 667 ASI------GQLLYIPCVVSSGDMPIRITWRKD-------GQVIISGSGVTIESKEFMSS 713
Query: 861 LEVRELGLGDSGSYRCEATNVLG--SSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQV 918
L++ + L +G+Y C A+N S L +V +V + + G+A VL+C V
Sbjct: 714 LQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSV 773
Query: 919 HTGVPEGTSYRWYR-DGQP-----------LQESTSATLRFAAITLTQAGAYHCQAQAPG 966
P ++ + G P +Q +++L + G Y CQA
Sbjct: 774 DGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQAS--N 831
Query: 967 SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLV 1024
T ++ + L V + G L C + P +R GD ++
Sbjct: 832 GVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVI 889
Score = 68.6 bits (166), Expect = 5e-11
Identities = 128/550 (23%), Positives = 208/550 (37%), Gaps = 84/550 (15%)
Query: 96 RVCNLLLKDLQPEDSGSYNFRFEISEV-NRWSDVKGTLVTVTEEPRVPTIASPVELLE-- 152
R+ L + DL+ EDSG+Y I EV N + + T + + +P T+ +P +L
Sbjct: 335 RITGLTISDLRTEDSGTY-----ICEVTNTFGSAEATGILMVIDPLHVTL-TPKKLKTGI 388
Query: 153 GTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHG 212
G+ V +C+ + + ++W + + G+ + ETL + + + H
Sbjct: 389 GSTVILSCA---LTGSPEFTIRWYRN---TELVLPDEAISIRGLSN-ETLLITSAQKSHS 441
Query: 213 RILRCQLSVANHRAQSEIHLQVKYAPKGV-KILLSPSGRNILPGELVTLTCQVNSSYP-- 269
+C A +AQ+ + G +I+ S S + + PGE +L C + P
Sbjct: 442 GAYQC---FATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPT 498
Query: 270 ---AVSSIKWLKDG------VRLQTKTGVLHL----PQAAWSDAGVYTCQAENGVGSLVS 316
A+ ++DG + T + H+ PQ D GVY C A N VGS
Sbjct: 499 VTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQI--RDGGVYRCTARNLVGSAE- 555
Query: 317 PPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDL------RYSWYKNHVLLEDA 370
+ A + V I + +T V + WYK+ +LL D
Sbjct: 556 -------YQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDN 608
Query: 371 H------SHTLRL-HLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLET 423
H + TL+L + D G Y C V S V V V PPL F
Sbjct: 609 HRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPF-EFPPA 667
Query: 424 QAGLVGILHCSVVSEPL-ATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLE 482
G + + C V S + + G ++ S SG + S F + L+I +
Sbjct: 668 SIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSS-------LQISSVS 720
Query: 483 ETDSGEYKCSATNSLGNATSTLDFHANA-ARLLISP-AAEVVEGQAVTLSCRSGLSPTPD 540
+G Y C A+N+ + R ++ P + + G+A L+C P P
Sbjct: 721 LKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPK 780
Query: 541 ARFSWYLNGA-------------LLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPS 587
+ + G+ + P SSLL+ D G Y C+A +G + S
Sbjct: 781 VMWK-HAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNG-VGTDIS 838
Query: 588 SPAVLTVLYP 597
LTV P
Sbjct: 839 KSMFLTVKIP 848
Score = 68.2 bits (165), Expect = 7e-11
Identities = 139/683 (20%), Positives = 239/683 (34%), Gaps = 92/683 (13%)
Query: 250 RNILPGELVTLTCQVNSSYPAVSSIKWLKDG------VRLQTKTGVLHLPQAAWSDAGVY 303
+ + G V L C S YP + +I+WLKDG R + L + D+G Y
Sbjct: 295 QEVWAGHTVELPCTA-SGYP-IPAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSGTY 352
Query: 304 TCQAENGVGSLVSPPISLHIFMAEVQVSPAG-PILENQTVTLVCNTPNEAPSDLRYSWYK 362
C+ N GS + I + I V ++P TV L C +R WY+
Sbjct: 353 ICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIR--WYR 410
Query: 363 NH--VLLEDAHS------HTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLT 414
N VL ++A S TL + A ++ +G Y C ++ + +++
Sbjct: 411 NTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFA--TRKAQTAQDFAIIALEDGTP 468
Query: 415 PVLTAFLE--TQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPN 472
++++F E G L C+ P T+ + + S + +++ + G
Sbjct: 469 RIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDG--SHRTNQYTMSDGTT 526
Query: 473 SLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANA-ARLLISPAAEVVEGQAVTLSC 531
+ + + D G Y+C+A N +G+A + + V G+ ++C
Sbjct: 527 ISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINC 586
Query: 532 RSGLSPTPDARFSWYLNGALLHEG-------PGSSLLLPAASSTDAGSYHCRARDGHSAS 584
R + P WY + LL + G+ L D G Y C S
Sbjct: 587 R--VIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLS 644
Query: 585 GPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDS-DPPARLQLLHKDRVV 643
S V + P QP + A G+ + C V S D P R+ +V+
Sbjct: 645 ISQSVHVAVKVPPLIQP-------FEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVI 697
Query: 644 ATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSAT 703
SG G + + + ++I + L+ G Y C ASNA S
Sbjct: 698 I----SGSG----------VTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRE-- 741
Query: 704 FNGQATVLAIAPSHTLQE-------GTEANLTCNVS-----------REAAGSPANFSWF 745
+ ++ + P +Q G L C+V + +G+P +
Sbjct: 742 ---RQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPV 798
Query: 746 RNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP---PDRPKLS 802
P ++ + V D Y C+ G +S + L+V P P +
Sbjct: 799 PLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTT 858
Query: 803 ALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSL--K 860
+ +GH CT ++ G+ T + P K + +
Sbjct: 859 IAI---KGHAKELNCTARGERPIIIRWEKGD----TVIDPDRVMRYAIATKDNGDEVVST 911
Query: 861 LEVRELGLGDSGSYRCEATNVLG 883
L+++ GDS + C A N G
Sbjct: 912 LKLKPADRGDSVFFSCHAINSYG 934
Score = 62.8 bits (151), Expect = 3e-09
Identities = 137/621 (22%), Positives = 232/621 (37%), Gaps = 88/621 (14%)
Query: 1065 YICEASNTLGQASASADFDAQAV-----NVQVWPGATVREGQLVNLTCLVWTTHPAQLTY 1119
Y C A N G+ S + +AV V+V ++R G + CL+ ++ ++
Sbjct: 161 YFCTAENAAGKIR-SPNIRVKAVFREPYTVRVEDQRSMR-GNVAVFKCLIPSSVQEYVSV 218
Query: 1120 -TWYQDGQQRLDAH--------SIPLPNVTVRDATS-YRC-------GVGPPGRAPRLSR 1162
+W +D + H + + +V DA S YRC G RLS
Sbjct: 219 VSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS- 277
Query: 1163 PITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPN 1222
+T P L + E G + CT P + GR L + + +
Sbjct: 278 -VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRI 336
Query: 1223 TLRLELRGPQPRDEGFYSCSARSPLGQAN-TSLELRLEGVRVILAPEAAVPE-GAPITVT 1280
T L + + D G Y C + G A T + + ++ + V L P+ G+ + ++
Sbjct: 337 T-GLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILS 395
Query: 1281 CADPAAHAPTLYTWYHNGRWLQEGPAASLSFLV--------ATRAHAGAYSCQAQDAQGT 1332
CA + T+ WY N + A S+ L A ++H+GAY C A T
Sbjct: 396 CALTGSPEFTI-RWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFA-----T 449
Query: 1333 RSSRPAALQVLYAPQDA---VLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHDGKVLA 1387
R ++ A + A +D ++SSF + + C PP + + D + +
Sbjct: 450 RKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIV 509
Query: 1388 TS----SGVHSLASGT--GHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQ 1441
+ ++++ GT H+ V +R Y CTA+NL+GS R+
Sbjct: 510 RDGSHRTNQYTMSDGTTISHMNVTGPQIR--------DGGVYRCTARNLVGSAEYQARIN 561
Query: 1442 VEGARVV-AEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRL---HAEPV---P 1494
V G + A + G ++CR++G P + W+ + L H + V
Sbjct: 562 VRGPPSIRAMRNITAVAGRDTLINCRVIGYP----YYSIKWYKDALLLPDNHRQVVFENG 617
Query: 1495 TLAFTHVARAQ-AGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGIL- 1552
TL T V + G Y C + + S V + V PP + F P + +L
Sbjct: 618 TLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPP---LIQPFEFPPASIGQLLY 674
Query: 1553 -DCRVDSEPLA-SLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGE 1610
C V S + +T +++ S ++ + L I ++ G
Sbjct: 675 IPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSL--------QISSVSLKHNGN 726
Query: 1611 YICSASNVLGSASTSTYFGVR 1631
Y C ASN + S VR
Sbjct: 727 YTCIASNAAATVSRERQLIVR 747
Score = 61.2 bits (147), Expect = 8e-09
Identities = 117/524 (22%), Positives = 182/524 (34%), Gaps = 57/524 (10%)
Query: 1052 LEIHGAMLEDEGVYICEASNTLGQASASADFDA-QAVNVQVWPGATVRE-GQLVNLTCLV 1109
L I ED G YICE +NT G A A+ ++V + P G V L+C +
Sbjct: 339 LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCAL 398
Query: 1110 WTTHPAQLTYTWYQDGQQRLDAHSIP---LPNVTVRDATSYRCGVGP----PGRAPRLSR 1162
T + T WY++ + L +I L N T+ ++ + G R + ++
Sbjct: 399 --TGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQ 456
Query: 1163 PITLDVLY--APRNLRLTYLLESHGGQLALVLCTVDSRPPAQLAL-----------SHAG 1209
+ L PR + + G+ ++C PP + SH
Sbjct: 457 DFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRT 516
Query: 1210 RLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEA 1269
S ++ + + + GPQ RD G Y C+AR+ +G A + + G I A
Sbjct: 517 NQYTMSDGTTISH---MNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRN 573
Query: 1270 AVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPA------ASLSFL-VATRAHAGAY 1322
T+ + WY + L + +L V G Y
Sbjct: 574 ITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEY 633
Query: 1323 SCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDS-EPPAELALSH 1381
C S+ + V P F + + I C V S + P +
Sbjct: 634 LCSVLIQPQLSISQSVHVAVKVPPLIQPFE-FPPASIGQLLYIPCVVSSGDMPIRITWRK 692
Query: 1382 DGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRL 1440
DG+V+ + SGV ++ LQ+ V + Y C A N ++S +L
Sbjct: 693 DGQVIISGSGVT--------IESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQL 744
Query: 1441 QVE-GARVVAEPG-LDVPEGAALNLSCRLLGGPGPVGNSTFA-WFWNDRRLHAEPVP--- 1494
V R V +P D G A L+C + G P P A N ++ H P+
Sbjct: 745 IVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRI 804
Query: 1495 ------TLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYP 1532
+L HV G Y C A G S + L V P
Sbjct: 805 QILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIP 848
Score = 52.0 bits (123), Expect = 5e-06
Identities = 69/281 (24%), Positives = 108/281 (38%), Gaps = 47/281 (16%)
Query: 171 VRLQWQGQDPA----RSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRA 226
+R+ W+ VT S++F + +L ++ H C S A
Sbjct: 686 IRITWRKDGQVIISGSGVTIESKEF-------MSSLQISSVSLKHNGNYTCIASNAAATV 738
Query: 227 QSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTK 286
E L V+ P+ V + P+ ++ + G+ L C V+ P K K Q
Sbjct: 739 SRERQLIVRVPPRFV---VQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQY 795
Query: 287 -----TGVLH-LPQAAW-------SDAGVYTCQAENGVGSLVSPPISLHI-FMAEVQVSP 332
TG + LP ++ D G Y CQA NGVG+ +S + L + A + P
Sbjct: 796 HPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHP 855
Query: 333 AGPI-LENQTVTLVCNTPNEAPSDLRYSWYKNHVLLE---------------DAHSHTLR 376
I ++ L C E P +R W K +++ D TL+
Sbjct: 856 NTTIAIKGHAKELNCTARGERPIIIR--WEKGDTVIDPDRVMRYAIATKDNGDEVVSTLK 913
Query: 377 LHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVL 417
L A R D+ F+ C N +G +R G + + V PP P L
Sbjct: 914 LKPADRGDSVFFSCHAINSYGEDR-GLIQLTVQEPPDPPEL 953
Score = 48.9 bits (115), Expect = 4e-05
Identities = 71/331 (21%), Positives = 109/331 (32%), Gaps = 34/331 (10%)
Query: 1332 TRSSRPAALQVLYAPQD--AVLSSFRDSR--ARSMAVIQCTVDSEPPAELALSHDGKVLA 1387
TR S A L V + +L F A + CT P + DG+ L
Sbjct: 268 TRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLP 327
Query: 1388 TSSGVHSLASGTGHVQVARNALRLQVQDVPAGDD-TYVCTAQNLLGSISTIGRLQV-EGA 1445
S +G L + D+ D TY+C N GS G L V +
Sbjct: 328 ADSRWTKRITG------------LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPL 375
Query: 1446 RVVAEPG-LDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPV--------PTL 1496
V P L G+ + LSC L G P T W+ N + + TL
Sbjct: 376 HVTLTPKKLKTGIGSTVILSCALTGSP----EFTIRWYRNTELVLPDEAISIRGLSNETL 431
Query: 1497 AFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRV 1556
T ++ +G Y C A A ++ P+ + G + L C
Sbjct: 432 LITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAA 491
Query: 1557 DSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSAS 1616
P ++T L + G+ + +++ + D G Y C+A
Sbjct: 492 KGAPPPTVTWALDDEPIVRD---GSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTAR 548
Query: 1617 NVLGSASTSTYFGVRALHRLHQFQQLLWVLG 1647
N++GSA VR + + + V G
Sbjct: 549 NLVGSAEYQARINVRGPPSIRAMRNITAVAG 579
Score = 46.2 bits (108), Expect = 3e-04
Identities = 123/573 (21%), Positives = 201/573 (35%), Gaps = 80/573 (13%)
Query: 1109 VWTTHPAQLTYT----------WYQDGQQRLDAHS--------IPLPNVTVRDATSYRCG 1150
VW H +L T W +DG+ L A S + + ++ D+ +Y C
Sbjct: 297 VWAGHTVELPCTASGYPIPAIRWLKDGRP-LPADSRWTKRITGLTISDLRTEDSGTYICE 355
Query: 1151 VGPP-GRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAG 1209
V G A + +D L+ + L++ G ++ C + P +
Sbjct: 356 VTNTFGSAEATGILMVIDPLHVTLTPKK---LKTGIGSTVILSCALTGSPEFTIRWYRNT 412
Query: 1210 RLLASSTAASVPNTLR--LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEG--VRVIL 1265
L+ A S+ L + Q G Y C A A + LE R++
Sbjct: 413 ELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVS 472
Query: 1266 A-PEAAVPEGAPITVTCADPAAHAPTLYTWY-----------HNGRWLQEGPAASLSFLV 1313
+ E V G ++ CA A PT+ TW H ++S +
Sbjct: 473 SFSEKVVNPGEQFSLMCAAKGAPPPTV-TWALDDEPIVRDGSHRTNQYTMSDGTTISHMN 531
Query: 1314 ATRAH---AGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVD 1370
T G Y C A++ G+ + A + V P + + R +I C V
Sbjct: 532 VTGPQIRDGGVYRCTARNLVGSAEYQ-ARINVRGPPSIRAMRNITAVAGRD-TLINCRVI 589
Query: 1371 SEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDT--YVCTA- 1427
P + D +L + H QV L++ DV G D Y+C+
Sbjct: 590 GYPYYSIKWYKDALLLPDN-----------HRQVVFENGTLKLTDVQKGMDEGEYLCSVL 638
Query: 1428 -QNLLGSISTIGRLQVEGARVVAEPGLDVPE--GAALNLSCRLLGGPGPVGNSTFAWFWN 1484
Q L SIS + V+ ++ +P P G L + C + G P+ W +
Sbjct: 639 IQPQL-SISQSVHVAVKVPPLI-QPFEFPPASIGQLLYIPCVVSSGDMPI---RITWRKD 693
Query: 1485 DRRLHA---------EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKT 1535
+ + + E + +L + V+ G Y C+A A S L V PP+
Sbjct: 694 GQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIAS-NAAATVSRERQLIVRVPPRF 752
Query: 1536 PTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNA 1595
+ G G+L+C VD P + Q P I +L + +
Sbjct: 753 VVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSL 812
Query: 1596 LRVDIEALRPSDQGEYICSASNVLGSASTSTYF 1628
L I + D G Y+C ASN +G+ + + F
Sbjct: 813 L---IRHVLEEDIGYYLCQASNGVGTDISKSMF 842
>gi|7657570 sialic acid binding Ig-like lectin 7 isoform 1 [Homo
sapiens]
Length = 467
Score = 90.5 bits (223), Expect = 1e-17
Identities = 86/344 (25%), Positives = 143/344 (41%), Gaps = 39/344 (11%)
Query: 16 AGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVP-DGITAIWYY---DYSGQRQVVS 71
+ + + ++ V +G C+ + C FS+P D + D + W+ D S + V +
Sbjct: 21 SNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDPVHGYWFRAGNDISWKAPVAT 80
Query: 72 HSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGT 131
++ V+ R R +G+P+ + C L ++D + D+G Y FR E + +W+
Sbjct: 81 NNP-AWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGRYFFRMEKGNI-KWNYKYDQ 138
Query: 132 L-VTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQ-EQVRLQWQGQ--DPARSVTFN 187
L V VT P I P L G + CS P+ C Q + W G P T
Sbjct: 139 LSVNVTALTHRPNILIPGTLESGCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTR 198
Query: 188 SQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSV--ANHRAQSEIHLQVKYAPKGVKI-- 243
S L + Q HG L CQ+++ A I L V Y P+ + +
Sbjct: 199 S-----------SVLTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTV 247
Query: 244 ----------LLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLP 293
L + S ++L G+ + L C V+S+ PA S W + + L L
Sbjct: 248 FQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQPSNPLVLE 307
Query: 294 -QAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPI 336
Q D G +TC+A+N +G S +SL++ + + P+
Sbjct: 308 LQVHLGDEGEFTCRAQNSLG---SQHVSLNLSLQQEYTGKMRPV 348
Score = 62.4 bits (150), Expect = 4e-09
Identities = 75/260 (28%), Positives = 101/260 (38%), Gaps = 45/260 (17%)
Query: 1035 EGSSPRLHVAVAPNTLR--LEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVW 1092
E + R H+ P T L I A + D G Y G + +D +VNV
Sbjct: 89 EETRDRFHLLGDPQTKNCTLSIRDARMSDAGRYFFRMEK--GNIKWNYKYDQLSVNVTAL 146
Query: 1093 --------PGATVREGQLVNLTCLV-WTTHPAQLTY-TWYQDGQQRLDAHS--------I 1134
PG T+ G NLTC V W +W L + I
Sbjct: 147 THRPNILIPG-TLESGCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTRSSVLTLI 205
Query: 1135 PLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYL-------------- 1180
P P TS C V PG +R I L+V Y P+NL +T
Sbjct: 206 PQPQ---HHGTSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNSS 262
Query: 1181 -LESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFY 1239
L GQ ++C VDS PPA+L+ + L S + N L LEL+ DEG +
Sbjct: 263 SLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQPS---NPLVLELQ-VHLGDEGEF 318
Query: 1240 SCSARSPLGQANTSLELRLE 1259
+C A++ LG + SL L L+
Sbjct: 319 TCRAQNSLGSQHVSLNLSLQ 338
Score = 57.4 bits (137), Expect = 1e-07
Identities = 57/196 (29%), Positives = 81/196 (41%), Gaps = 43/196 (21%)
Query: 718 TLQEGTEANLTCNVSREAA-GSPANFSWFRNGVLWAQGPLE-------TVTLLPVARTDA 769
TL+ G NLTC+V G+P SW V PL +TL+P +
Sbjct: 157 TLESGCFQNLTCSVPWACEQGTPPMISWMGTSV----SPLHPSTTRSSVLTLIPQPQHHG 212
Query: 770 ALYACRI-LTEAGAQLSTPVLLSVLYPPDRPKL---------------SALLDMGQGHMA 813
C++ L AG + + L+V YPP + S+ L + +G
Sbjct: 213 TSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSL 272
Query: 814 LFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGS 873
+C VDS P A L+ + +L P PS N L LE+ ++ LGD G
Sbjct: 273 RLVCAVDSNPPARLSWTWR----SLTLYPSQPS----------NPLVLEL-QVHLGDEGE 317
Query: 874 YRCEATNVLGSSNTSL 889
+ C A N LGS + SL
Sbjct: 318 FTCRAQNSLGSQHVSL 333
Score = 55.8 bits (133), Expect = 3e-07
Identities = 64/259 (24%), Positives = 100/259 (38%), Gaps = 50/259 (19%)
Query: 855 EANSLKLEVRELGLGDSGSY--RCEATNVLGSSNTSLFFQVRGAWVQVSPSPE------L 906
+ + L +R+ + D+G Y R E N+ + + Q+ ++ P L
Sbjct: 102 QTKNCTLSIRDARMSDAGRYFFRMEKGNIKWNYK---YDQLSVNVTALTHRPNILIPGTL 158
Query: 907 QEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYH-----CQ 961
+ G L+C V +GT G + +T R + +TL +H CQ
Sbjct: 159 ESGCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQ 218
Query: 962 AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGL---------------LLCR 1006
PG+ T+ I L+VSY P+++T+T G L L+C
Sbjct: 219 VTLPGAGVTTNRT-IQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCA 277
Query: 1007 VDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYI 1066
VDS+PPA+L S L+ + N L LE+ L DEG +
Sbjct: 278 VDSNPPARLSW-----------------TWRSLTLYPSQPSNPLVLELQ-VHLGDEGEFT 319
Query: 1067 CEASNTLGQASASADFDAQ 1085
C A N+LG S + Q
Sbjct: 320 CRAQNSLGSQHVSLNLSLQ 338
Score = 42.4 bits (98), Expect = 0.004
Identities = 35/126 (27%), Positives = 49/126 (38%), Gaps = 31/126 (24%)
Query: 592 LTVLYPPRQPTFTTRLDLDAAGAGAGRRGLL----------LCRVDSDPPARLQLLHKDR 641
L V YPP+ T T A G L +C VDS+PPARL +
Sbjct: 234 LNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSL 293
Query: 642 VVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTS 701
+ S PS P +L +++H L +EG + C A N+LG+ S
Sbjct: 294 TLYPSQPSN------------------PLVLELQVH---LGDEGEFTCRAQNSLGSQHVS 332
Query: 702 ATFNGQ 707
+ Q
Sbjct: 333 LNLSLQ 338
Score = 40.0 bits (92), Expect = 0.019
Identities = 39/132 (29%), Positives = 52/132 (39%), Gaps = 33/132 (25%)
Query: 1511 CLAELP-TGAAASAPVMLRVLYPPKTPTMMVFVEPEG----------------GLRGILD 1553
C LP G + + L V YPP+ T+ VF + EG G L
Sbjct: 217 CQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVF-QGEGTASTALGNSSSLSVLEGQSLRLV 275
Query: 1554 CRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYIC 1613
C VDS P A L+ S + SQP ++P L + + D+GE+ C
Sbjct: 276 CAVDSNPPARLSWTWRSLTLYPSQP------------SNPLVLELQVHL---GDEGEFTC 320
Query: 1614 SASNVLGSASTS 1625
A N LGS S
Sbjct: 321 RAQNSLGSQHVS 332
Score = 38.9 bits (89), Expect = 0.043
Identities = 35/141 (24%), Positives = 54/141 (38%), Gaps = 30/141 (21%)
Query: 1309 LSFLVATRAHAGAYSCQAQ-DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAV--- 1364
L+ + + H + +CQ G ++R L V Y PQ+ ++ F+ S A+
Sbjct: 202 LTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNS 261
Query: 1365 ------------IQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQ 1412
+ C VDS PPA L+ + L S N L L+
Sbjct: 262 SSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQ--------------PSNPLVLE 307
Query: 1413 VQDVPAGDDTYVCTAQNLLGS 1433
+Q + + C AQN LGS
Sbjct: 308 LQVHLGDEGEFTCRAQNSLGS 328
Score = 31.6 bits (70), Expect = 6.9
Identities = 29/103 (28%), Positives = 43/103 (41%), Gaps = 4/103 (3%)
Query: 516 SPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEG-PGSSLLLP-AASSTDAGSY 573
S + V+EGQ++ L C + P AR SW L+ P + L+L D G +
Sbjct: 261 SSSLSVLEGQSLRLVC--AVDSNPPARLSWTWRSLTLYPSQPSNPLVLELQVHLGDEGEF 318
Query: 574 HCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGA 616
CRA++ + S L Y + + L GAGA
Sbjct: 319 TCRAQNSLGSQHVSLNLSLQQEYTGKMRPVSGVLLGAVGGAGA 361
>gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens]
Length = 708
Score = 90.1 bits (222), Expect = 2e-17
Identities = 119/437 (27%), Positives = 177/437 (40%), Gaps = 70/437 (16%)
Query: 681 LEEEGLYLCEASNALGNASTSATFN----GQATVLAIAPSHTLQEGTEANLTCNVSREAA 736
LE+E Y C+A+ A G S A + +A + PS +L G ANLTC +A
Sbjct: 95 LEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDAR 153
Query: 737 GSPANFSWFRNGVLW-------------AQGPLE-TVTLLPVARTDAALYACRILTEA-G 781
+P WFR+GVL G +E T+TL P + D A + CR ++A
Sbjct: 154 PTP-ELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALP 212
Query: 782 AQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLG 841
T + LS+ YPP+ ++ + +G +F+C ++P + A
Sbjct: 213 TGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT------GYRWAKGGS 266
Query: 842 PQVPSHG-RFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR-GAWVQ 899
P + + G R + A+A+ L V CE +N +GS+N S V G +Q
Sbjct: 267 PVLGARGPRLEVVADASFLTEPVS-----------CEVSNAVGSANRSTALDVLFGPILQ 315
Query: 900 VSPSP-ELQEGQAVVLSCQVHTG-VPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGA 957
P P + G+ SC +P T W R G + ATLR ++ AG
Sbjct: 316 AKPEPVSVDVGEDASFSCAWRGNPLPRVT---WTRRGGAQVLGSGATLRLPSVGPEDAGD 372
Query: 958 YHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRL---GLLLCRVDSDPPAQ 1014
Y C+A+A S AA L V+ P + T + + P L L C V + P
Sbjct: 373 YVCRAEAGLSGLRGGAAEARLTVNAPP----VVTALHSAPAFLRGPARLQCLVFASPAP- 427
Query: 1015 LRLLHGDRLVASTLQGV--GGPEG-------SSPRLHVAVAPNTLR-LEIHGAMLED-EG 1063
D +V S +G G +G +P + P + L I G D
Sbjct: 428 ------DAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSR 481
Query: 1064 VYICEASNTLGQASASA 1080
+ C A N LG+ A A
Sbjct: 482 SFNCSARNRLGEGGAQA 498
Score = 72.4 bits (176), Expect = 4e-12
Identities = 96/400 (24%), Positives = 150/400 (37%), Gaps = 72/400 (18%)
Query: 244 LLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV-------------- 289
L P +L GE L C + + + V +W K G+ L + +
Sbjct: 27 LQQPEDLVVLLGEEARLPCALGAYWGLV---QWTKSGLALGGQRDLPGWSRYWISGNAAN 83
Query: 290 ----LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA----EVQVSPAGPILENQT 341
LH+ D Y CQA L S P LH+ + +V P+ ++
Sbjct: 84 GQHDLHIRPVELEDEASYECQATQA--GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVP 141
Query: 342 VTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSH--------------TLRLHLATRADTGF 387
L C + +A W+++ VLL+ A H TL L + D
Sbjct: 142 ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGAT 201
Query: 388 YFCEVQN-VHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLS 446
+ C ++ + R +++ + +PP + + Q G I C ++P T
Sbjct: 202 FVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT---- 257
Query: 447 HGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDF 506
G+ A SP G GP RLE+ + C +N++G+A
Sbjct: 258 --GYRWAKGG-----SPVL-GARGP---RLEVVADASFLTEPVSCEVSNAVGSAN----- 301
Query: 507 HANAARLLISPAAE-------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSS 559
+ A +L P + V G+ + SC +P P R +W G G G++
Sbjct: 302 RSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLP--RVTWTRRGGAQVLGSGAT 359
Query: 560 LLLPAASSTDAGSYHCRARDGHSA-SGPSSPAVLTVLYPP 598
L LP+ DAG Y CRA G S G ++ A LTV PP
Sbjct: 360 LRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPP 399
Score = 56.6 bits (135), Expect = 2e-07
Identities = 115/477 (24%), Positives = 165/477 (34%), Gaps = 67/477 (14%)
Query: 861 LEVRELGLGDSGSYRCEATNV-LGSSNTSLFFQVRGAWVQV--SPSPELQEGQAVVLSCQ 917
L +R + L D SY C+AT L S L V QV PS L G L+C+
Sbjct: 88 LHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCR 147
Query: 918 VHTGVPEGTSYRWYRDGQPLQEST--------------SATLRFAAITLTQAGAYHCQAQ 963
W+RDG L +T +TL + + C+A+
Sbjct: 148 SRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRAR 207
Query: 964 APGSATTSLAAPISLHVSYAPRHVTLTTLMDT-GPGRLGLLLCRVDSDPPAQ-LRLLHGD 1021
+ + T I+L + Y P VTL+ T G + LC+ + PP R G
Sbjct: 208 SQ-ALPTGRDTAITLSLQYPP-EVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKG- 264
Query: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081
S + G G PRL V + L + CE SN +G A+ S
Sbjct: 265 ---GSPVLGARG-----PRLEVVADASFLTEPVS-----------CEVSNAVGSANRSTA 305
Query: 1082 FDAQ-AVNVQVWP-GATVREGQLVNLTCLVWTTHP-AQLTYTWYQDGQQRLDAHSIPLPN 1138
D +Q P +V G+ + +C W +P ++T+T Q ++ LP+
Sbjct: 306 LDVLFGPILQAKPEPVSVDVGEDASFSC-AWRGNPLPRVTWTRRGGAQVLGSGATLRLPS 364
Query: 1139 VTVRDATSYRC----------GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQL 1188
V DA Y C G R + P+ + AP LR L+
Sbjct: 365 VGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFAS 424
Query: 1189 ALVLCTVDSRPPAQLALSHAGRLLASSTAASV------PNTLR-LELRGPQPRD-EGFYS 1240
V S L GR L + A P + L + G Q D ++
Sbjct: 425 PAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFN 484
Query: 1241 CSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN 1297
CSAR+ LG+ L R L P + G T L W H+
Sbjct: 485 CSARNRLGEGGAQASLG----RRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHS 537
Score = 48.1 bits (113), Expect = 7e-05
Identities = 111/483 (22%), Positives = 164/483 (33%), Gaps = 71/483 (14%)
Query: 1226 LELRGPQPRDEGFYSCSARSPLGQANTSLELRL----EGVRVILAPEAAVPEGAPITVTC 1281
L +R + DE Y C A + G + +L + E +V+ P ++ G P +TC
Sbjct: 88 LHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 146
Query: 1282 ADPAAHAPT-LYTWYHNG----------RWLQEGPAAS----LSFLVATRAHAGAYSCQA 1326
PT W+ +G L+EG S L+ + + C+A
Sbjct: 147 RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 206
Query: 1327 Q-DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKV 1385
+ A T L + Y P+ + +S + + C ++PP
Sbjct: 207 RSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT--------- 257
Query: 1386 LATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV-EG 1444
+ A G V AR V D + C N +GS + L V G
Sbjct: 258 ------GYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFG 311
Query: 1445 ARVVAEP-GLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPV---PTLAFTH 1500
+ A+P + V G + SC G P P W RR A+ + TL
Sbjct: 312 PILQAKPEPVSVDVGEDASFSCAWRGNPLP----RVTW---TRRGGAQVLGSGATLRLPS 364
Query: 1501 VARAQAGMYHCLAELP----TGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRG--ILDC 1554
V AG Y C AE G AA A + + P + LRG L C
Sbjct: 365 VGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNA-----PPVVTALHSAPAFLRGPARLQC 419
Query: 1555 RVDSEPLASLTLHLGSRLVASSQPQGA------PAEPHIHVLASPNALRV-DIEALRPSD 1607
V + P + + QG PA P P + V I + SD
Sbjct: 420 LVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPA-PESRGGLGPGLISVLHISGTQESD 478
Query: 1608 -QGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWR 1666
+ CSA N LG G R L L + + V LL+++ G+ C WR
Sbjct: 479 FSRSFNCSARNRLGEGGAQASLGRRDL--LPTVRIVAGVAAATTTLLMVITGVALC-CWR 535
Query: 1667 RRR 1669
+
Sbjct: 536 HSK 538
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,691,363
Number of Sequences: 37866
Number of extensions: 3649134
Number of successful extensions: 21491
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 214
Number of HSP's successfully gapped in prelim test: 280
Number of HSP's that attempted gapping in prelim test: 10018
Number of HSP's gapped (non-prelim): 6409
length of query: 1709
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1593
effective length of database: 13,855,062
effective search space: 22071113766
effective search space used: 22071113766
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.