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Search of human proteins with 60685231
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|60685231 tetratricopeptide repeat domain 7B [Homo sapiens]
(843 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|60685231 tetratricopeptide repeat domain 7B [Homo sapiens] 1658 0.0
gi|110225358 tetratricopeptide repeat domain 7A [Homo sapiens] 827 0.0
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 61 4e-09
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 61 4e-09
gi|118766328 transmembrane and tetratricopeptide repeat containi... 51 4e-06
gi|118766330 transmembrane and tetratricopeptide repeat containi... 51 4e-06
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] 47 6e-05
gi|83415184 transmembrane and tetratricopeptide repeat containin... 46 1e-04
gi|7661910 tetratricopeptide repeat domain 35 [Homo sapiens] 44 5e-04
gi|22749211 transmembrane and tetratricopeptide repeat containin... 43 0.001
gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens] 41 0.005
gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo sa... 40 0.012
gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo sa... 40 0.012
gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo sa... 40 0.012
gi|42476022 tetratricopeptide repeat domain 27 [Homo sapiens] 38 0.034
gi|226498382 tetratricopeptide repeat domain 5 [Homo sapiens] 38 0.045
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi... 38 0.045
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi... 38 0.045
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 37 0.077
gi|224809432 transmembrane and tetratricopeptide repeat containi... 36 0.17
gi|118402596 cell division cycle protein 23 [Homo sapiens] 36 0.17
gi|17149828 NMDA receptor regulated 1 [Homo sapiens] 36 0.17
gi|118402578 anaphase-promoting complex, subunit 6 [Homo sapiens] 35 0.22
gi|118402580 anaphase-promoting complex, subunit 6 [Homo sapiens] 35 0.22
gi|229577238 tetratricopeptide repeat domain 18 [Homo sapiens] 35 0.38
gi|157502179 tetratricopeptide repeat domain 21A isoform 1 [Homo... 35 0.38
gi|157502177 tetratricopeptide repeat domain 21A isoform 2 [Homo... 35 0.38
gi|21361787 tetratricopeptide repeat domain 17 [Homo sapiens] 35 0.38
gi|109638749 signal recognition particle 72kDa [Homo sapiens] 34 0.50
gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens] 33 1.4
>gi|60685231 tetratricopeptide repeat domain 7B [Homo sapiens]
Length = 843
Score = 1658 bits (4293), Expect = 0.0
Identities = 843/843 (100%), Positives = 843/843 (100%)
Query: 1 MATKKAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQYLKEH 60
MATKKAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQYLKEH
Sbjct: 1 MATKKAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQYLKEH 60
Query: 61 PLRQGASPRGPKPQLTEVRKHLTAALDRGNLKSEFLQESNLIMAKLNYVEGDYKEALNIY 120
PLRQGASPRGPKPQLTEVRKHLTAALDRGNLKSEFLQESNLIMAKLNYVEGDYKEALNIY
Sbjct: 61 PLRQGASPRGPKPQLTEVRKHLTAALDRGNLKSEFLQESNLIMAKLNYVEGDYKEALNIY 120
Query: 121 ARVGLDDLPLTAVPPYRLRVIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAG 180
ARVGLDDLPLTAVPPYRLRVIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAG
Sbjct: 121 ARVGLDDLPLTAVPPYRLRVIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAG 180
Query: 181 DIALLYLQEIERVILSNIQNRSPKPGPAPHDQELGFFLETGLQRAHVLYFKNGNLTRGVG 240
DIALLYLQEIERVILSNIQNRSPKPGPAPHDQELGFFLETGLQRAHVLYFKNGNLTRGVG
Sbjct: 181 DIALLYLQEIERVILSNIQNRSPKPGPAPHDQELGFFLETGLQRAHVLYFKNGNLTRGVG 240
Query: 241 RFRELLRAVETRTTQNLRMTIARQLAEILLRGMCEQSYWNPLEDPPCQSPLDDPLRKGAN 300
RFRELLRAVETRTTQNLRMTIARQLAEILLRGMCEQSYWNPLEDPPCQSPLDDPLRKGAN
Sbjct: 241 RFRELLRAVETRTTQNLRMTIARQLAEILLRGMCEQSYWNPLEDPPCQSPLDDPLRKGAN 300
Query: 301 TKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLISLQ 360
TKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLISLQ
Sbjct: 301 TKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLISLQ 360
Query: 361 SASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVL 420
SASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVL
Sbjct: 361 SASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVL 420
Query: 421 KECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTY 480
KECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTY
Sbjct: 421 KECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTY 480
Query: 481 SLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQ 540
SLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQ
Sbjct: 481 SLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQ 540
Query: 541 ALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPD 600
ALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPD
Sbjct: 541 ALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPD 600
Query: 601 EALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETGSVHA 660
EALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETGSVHA
Sbjct: 601 EALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETGSVHA 660
Query: 661 TSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQ 720
TSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQ
Sbjct: 661 TSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQ 720
Query: 721 EAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRY 780
EAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRY
Sbjct: 721 EAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRY 780
Query: 781 SLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPFTIIP 840
SLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPFTIIP
Sbjct: 781 SLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPFTIIP 840
Query: 841 RVL 843
RVL
Sbjct: 841 RVL 843
>gi|110225358 tetratricopeptide repeat domain 7A [Homo sapiens]
Length = 858
Score = 827 bits (2136), Expect = 0.0
Identities = 431/867 (49%), Positives = 615/867 (70%), Gaps = 33/867 (3%)
Query: 1 MATKKA-GS--RLETEIERCRSECQWERIPELVKQLSAKLIAN----------------- 40
MA K A GS ++E+E+ERCR+E W+R+PELV+QL +
Sbjct: 1 MAAKGAHGSYLKVESELERCRAEGHWDRMPELVRQLQTLSMPGGGGNRRGSPSAAFTFPD 60
Query: 41 -DDMAELLLGESKLEQYLKE-HPLRQGASPRGPK--PQLTEVRKHLTAALDRGNLKSEFL 96
DD +LLL E+ LEQ LKE H + + P K P+++E + +L++ L+ G L +++
Sbjct: 61 TDDFGKLLLAEALLEQCLKENHAKIKDSMPLLEKNEPKMSEAKNYLSSILNHGRLSPQYM 120
Query: 97 QESNLIMAKLNYVEGDYKEALNIYARVGLDDLPLTAVPPYRLRVIAEAYATKGLCLEKLP 156
E+ LI+ KL+YVEG Y++A+++YAR G+DD+ + P Y++R+++EA+ KGL LE+LP
Sbjct: 121 CEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLSEAFVIKGLSLERLP 180
Query: 157 ISSSTSNLHVDREQDVITCYEKAGDIALLYLQEIERVILSNIQNRSPKPGPAPHDQELGF 216
S ++ +RE++VITC+E+A IA ++LQE+E+ +N +R K G P D EL +
Sbjct: 181 NSIASRFRLTEREEEVITCFERASWIAQVFLQELEKTT-NNSTSRHLK-GCHPLDYELTY 238
Query: 217 FLETGLQRAHVLYFKNGNLTRGVGRFRELLRAVETRTTQNLRMTIARQLAEILLRGMCEQ 276
FLE LQ A+V K GN+ +G+ RE+LR VET+ TQN ++ A+ LA +LL + E+
Sbjct: 239 FLEAALQSAYVKNLKKGNIVKGMRELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEE 298
Query: 277 SYWNPLEDPPCQSPLDDPLRKGANTKTYTLTRRARVYSGENIFCPQENTEEALLLLLISE 336
YW+PL P L + + K ++ R+ +Y G+N++CP++N EEALLLLLISE
Sbjct: 299 CYWSPLSHP-----LPEFMGKEESSFATQALRKPHLYEGDNLYCPKDNIEEALLLLLISE 353
Query: 337 SMANRDAVLSRIPEHKSDRLISLQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEE 396
SMA RD VLSR+PE + DR +SLQ+A+ +YDLL+I LGRRGQY MLSECLERAMKFAF E
Sbjct: 354 SMATRDVVLSRVPEQEEDRTVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGE 413
Query: 397 FHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAK 456
FHLWYQ ALS++A GKSA AV +L+EC++L+P D T+PL+AAK+C+GSL WLEEAE FA
Sbjct: 414 FHLWYQVALSMVACGKSAYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLRWLEEAEHFAM 473
Query: 457 TVVDVGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQ 516
V+ +GE+ EF KGYLALGLTYSLQATDA+L+ Q+ L RKAL +RA L+P+D Q
Sbjct: 474 MVISLGEEAGEFLPKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPSDPQ 533
Query: 517 AAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMAL 576
Y++LQLA+ RQI A+ +++AL+++ DDA++LHLLALL SAQKH+ AL++++MA+
Sbjct: 534 VILYVSLQLALVRQISSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAI 593
Query: 577 SEYPENFILLFSKVKLQSLCRGPDEALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTI 636
+E+PENF L+F+KVKL+ + +GP+EAL+TC+ +L++W++ Y+ + + S +
Sbjct: 594 TEHPENFNLMFTKVKLEQVLKGPEEALVTCRQVLRLWQTLYSFSQLGGLEKDGSFGEGLT 653
Query: 637 ADRRQLNTITLPDFSDPETGSVHATSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLA 696
++ +TLPD D ++GS A+S+AASR+E+A+SE+ ++ SS KQGP+ W TL
Sbjct: 654 MKKQSGMHLTLPDAHDADSGSRRASSIAASRLEEAMSEL--TMPSSVLKQGPMQLWTTLE 711
Query: 697 QIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEA 756
QIWL AAE+++ EA C QEAA LFP SH+VLYMRG++AE++G+++EA++ Y+EA
Sbjct: 712 QIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEA 771
Query: 757 LAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAA 816
L ++P V+ M L L+L +LG SLA+K+LRDAV+ ST HE W GLGEVLQAQG + A
Sbjct: 772 LTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEA 831
Query: 817 ATECFLTALELEASSPAVPFTIIPRVL 843
A +CFLTALELEASSP +PF+IIPR L
Sbjct: 832 AVDCFLTALELEASSPVLPFSIIPREL 858
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 61.2 bits (147), Expect = 4e-09
Identities = 97/429 (22%), Positives = 166/429 (38%), Gaps = 49/429 (11%)
Query: 410 AGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHW----LEEAEKFAKTVVDVGEKT 465
AG A + + R +PD+ + LL + S+H+ L+ + F+ + K
Sbjct: 24 AGDFEAAERHCMQLWRQEPDNTGVLLL-----LSSIHFQCRRLDRSAHFSTLAI----KQ 74
Query: 466 SEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQL 525
+ A+ Y LG Y + +QE ++ ++ A L P LA L
Sbjct: 75 NPLLAEAYSNLGNVYKERGQ------LQEAIEH-----YRHALRLKPDFIDGYINLAAAL 123
Query: 526 AISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFIL 585
+ + A+ ALQ D L LL A +A A+ P NF +
Sbjct: 124 VAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQP-NFAV 182
Query: 586 LFSKVKLQSLCRGPDEALLTCKHMLQ-------IWKSCYNLTNPSDSGRGSSLLDRTIAD 638
+S + +G E L H + + NL N R + DR +A
Sbjct: 183 AWSNLGCVFNAQG--EIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEAR---IFDRAVA- 236
Query: 639 RRQLNTITLPDFSDPETGSVHATSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQI 698
L ++L P VH ++A EQ L ++A A + P P
Sbjct: 237 -AYLRALSL----SPNHAVVHG-NLACVYYEQGLIDLAIDTYRRAIELQPHFP-----DA 285
Query: 699 WLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALA 758
+ + A G AEA C A L P + L I +G+++EA R Y +AL
Sbjct: 286 YCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALE 345
Query: 759 ISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAAT 818
+ P + LA +L Q G+ A ++A++++ T + ++ +G L+ + A
Sbjct: 346 VFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGAL 405
Query: 819 ECFLTALEL 827
+C+ A+++
Sbjct: 406 QCYTRAIQI 414
Score = 45.1 bits (105), Expect = 3e-04
Identities = 30/123 (24%), Positives = 53/123 (43%)
Query: 710 GKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQR 769
G EA ++A +FP + + +G + EA Y+EA+ ISPT +
Sbjct: 331 GNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSN 390
Query: 770 LALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEA 829
+ L ++ A + A+Q+N + + L + + GN A + TAL+L+
Sbjct: 391 MGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKP 450
Query: 830 SSP 832
P
Sbjct: 451 DFP 453
Score = 43.5 bits (101), Expect = 8e-04
Identities = 28/92 (30%), Positives = 42/92 (45%)
Query: 737 GQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNST 796
G + + RG + EA Y AL + P + LA L G A + A+Q N
Sbjct: 86 GNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPD 145
Query: 797 AHEVWNGLGEVLQAQGNDAAATECFLTALELE 828
+ V + LG +L+A G A C+L A+E +
Sbjct: 146 LYCVRSDLGNLLKALGRLEEAKACYLKAIETQ 177
Score = 38.1 bits (87), Expect = 0.034
Identities = 40/146 (27%), Positives = 56/146 (38%), Gaps = 5/146 (3%)
Query: 683 APKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAEL 742
A KQ PL LA+ + + VY G+ EA + A L P +
Sbjct: 71 AIKQNPL-----LAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVA 125
Query: 743 RGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWN 802
G M+ A + Y AL +P L +L LGR A+ A++ W+
Sbjct: 126 AGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWS 185
Query: 803 GLGEVLQAQGNDAAATECFLTALELE 828
LG V AQG A F A+ L+
Sbjct: 186 NLGCVFNAQGEIWLAIHHFEKAVTLD 211
Score = 32.0 bits (71), Expect = 2.5
Identities = 46/184 (25%), Positives = 75/184 (40%), Gaps = 20/184 (10%)
Query: 366 YDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIR 425
Y L AL +G +C A++ A G AV++ ++ +
Sbjct: 286 YCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALE 345
Query: 426 LKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGE--KTSEFKAKGYLALGLTYSLQ 483
+ P+ A AA + S+ L++ K + ++ E + S A Y +G T
Sbjct: 346 VFPEFA-----AAHSNLASV--LQQQGKLQEALMHYKEAIRISPTFADAYSNMGNT---- 394
Query: 484 ATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQ 543
L+ MQ+V + AL + RA ++P A LA S IPEA+ R AL+
Sbjct: 395 -----LKEMQDV--QGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALK 447
Query: 544 LQGD 547
L+ D
Sbjct: 448 LKPD 451
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 61.2 bits (147), Expect = 4e-09
Identities = 97/429 (22%), Positives = 166/429 (38%), Gaps = 49/429 (11%)
Query: 410 AGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHW----LEEAEKFAKTVVDVGEKT 465
AG A + + R +PD+ + LL + S+H+ L+ + F+ + K
Sbjct: 34 AGDFEAAERHCMQLWRQEPDNTGVLLL-----LSSIHFQCRRLDRSAHFSTLAI----KQ 84
Query: 466 SEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQL 525
+ A+ Y LG Y + +QE ++ ++ A L P LA L
Sbjct: 85 NPLLAEAYSNLGNVYKERGQ------LQEAIEH-----YRHALRLKPDFIDGYINLAAAL 133
Query: 526 AISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFIL 585
+ + A+ ALQ D L LL A +A A+ P NF +
Sbjct: 134 VAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQP-NFAV 192
Query: 586 LFSKVKLQSLCRGPDEALLTCKHMLQ-------IWKSCYNLTNPSDSGRGSSLLDRTIAD 638
+S + +G E L H + + NL N R + DR +A
Sbjct: 193 AWSNLGCVFNAQG--EIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEAR---IFDRAVA- 246
Query: 639 RRQLNTITLPDFSDPETGSVHATSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQI 698
L ++L P VH ++A EQ L ++A A + P P
Sbjct: 247 -AYLRALSL----SPNHAVVHG-NLACVYYEQGLIDLAIDTYRRAIELQPHFP-----DA 295
Query: 699 WLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALA 758
+ + A G AEA C A L P + L I +G+++EA R Y +AL
Sbjct: 296 YCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALE 355
Query: 759 ISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAAT 818
+ P + LA +L Q G+ A ++A++++ T + ++ +G L+ + A
Sbjct: 356 VFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGAL 415
Query: 819 ECFLTALEL 827
+C+ A+++
Sbjct: 416 QCYTRAIQI 424
Score = 45.1 bits (105), Expect = 3e-04
Identities = 30/123 (24%), Positives = 53/123 (43%)
Query: 710 GKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQR 769
G EA ++A +FP + + +G + EA Y+EA+ ISPT +
Sbjct: 341 GNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSN 400
Query: 770 LALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEA 829
+ L ++ A + A+Q+N + + L + + GN A + TAL+L+
Sbjct: 401 MGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKP 460
Query: 830 SSP 832
P
Sbjct: 461 DFP 463
Score = 43.5 bits (101), Expect = 8e-04
Identities = 28/92 (30%), Positives = 42/92 (45%)
Query: 737 GQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNST 796
G + + RG + EA Y AL + P + LA L G A + A+Q N
Sbjct: 96 GNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPD 155
Query: 797 AHEVWNGLGEVLQAQGNDAAATECFLTALELE 828
+ V + LG +L+A G A C+L A+E +
Sbjct: 156 LYCVRSDLGNLLKALGRLEEAKACYLKAIETQ 187
Score = 38.1 bits (87), Expect = 0.034
Identities = 40/146 (27%), Positives = 56/146 (38%), Gaps = 5/146 (3%)
Query: 683 APKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAEL 742
A KQ PL LA+ + + VY G+ EA + A L P +
Sbjct: 81 AIKQNPL-----LAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVA 135
Query: 743 RGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWN 802
G M+ A + Y AL +P L +L LGR A+ A++ W+
Sbjct: 136 AGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWS 195
Query: 803 GLGEVLQAQGNDAAATECFLTALELE 828
LG V AQG A F A+ L+
Sbjct: 196 NLGCVFNAQGEIWLAIHHFEKAVTLD 221
Score = 32.0 bits (71), Expect = 2.5
Identities = 46/184 (25%), Positives = 75/184 (40%), Gaps = 20/184 (10%)
Query: 366 YDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIR 425
Y L AL +G +C A++ A G AV++ ++ +
Sbjct: 296 YCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALE 355
Query: 426 LKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGE--KTSEFKAKGYLALGLTYSLQ 483
+ P+ A AA + S+ L++ K + ++ E + S A Y +G T
Sbjct: 356 VFPEFA-----AAHSNLASV--LQQQGKLQEALMHYKEAIRISPTFADAYSNMGNT---- 404
Query: 484 ATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQ 543
L+ MQ+V + AL + RA ++P A LA S IPEA+ R AL+
Sbjct: 405 -----LKEMQDV--QGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALK 457
Query: 544 LQGD 547
L+ D
Sbjct: 458 LKPD 461
>gi|118766328 transmembrane and tetratricopeptide repeat containing
4 isoform 2 [Homo sapiens]
Length = 741
Score = 51.2 bits (121), Expect = 4e-06
Identities = 32/113 (28%), Positives = 55/113 (48%)
Query: 720 QEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGR 779
+ A ++ P++ V Y G+ +G+ A R+Y EA+ ++P +V +M L IL +
Sbjct: 472 RSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNE 531
Query: 780 YSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSP 832
AE++L AVQ+ W LG V + AA + + TA++ P
Sbjct: 532 LQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYP 584
Score = 32.7 bits (73), Expect = 1.4
Identities = 20/87 (22%), Positives = 37/87 (42%), Gaps = 1/87 (1%)
Query: 740 AELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHE 799
A+L +D W A + P H + + ++L G + AE + R+A+++ H
Sbjct: 595 ADLNRHVDALNAW-RNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHS 653
Query: 800 VWNGLGEVLQAQGNDAAATECFLTALE 826
+ L VL + FL A++
Sbjct: 654 LMFSLANVLGKSQKYKESEALFLKAIK 680
>gi|118766330 transmembrane and tetratricopeptide repeat containing
4 isoform 1 [Homo sapiens]
Length = 760
Score = 51.2 bits (121), Expect = 4e-06
Identities = 32/113 (28%), Positives = 55/113 (48%)
Query: 720 QEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGR 779
+ A ++ P++ V Y G+ +G+ A R+Y EA+ ++P +V +M L IL +
Sbjct: 491 RSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNE 550
Query: 780 YSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSP 832
AE++L AVQ+ W LG V + AA + + TA++ P
Sbjct: 551 LQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYP 603
Score = 32.7 bits (73), Expect = 1.4
Identities = 20/87 (22%), Positives = 37/87 (42%), Gaps = 1/87 (1%)
Query: 740 AELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHE 799
A+L +D W A + P H + + ++L G + AE + R+A+++ H
Sbjct: 614 ADLNRHVDALNAW-RNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHS 672
Query: 800 VWNGLGEVLQAQGNDAAATECFLTALE 826
+ L VL + FL A++
Sbjct: 673 LMFSLANVLGKSQKYKESEALFLKAIK 699
>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
Length = 519
Score = 47.4 bits (111), Expect = 6e-05
Identities = 32/105 (30%), Positives = 56/105 (53%), Gaps = 2/105 (1%)
Query: 730 HNVLY-MRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILR 788
H++ Y M G+I L G +D+A Y++A+ SP + + + L L+ QLG Y A + L
Sbjct: 167 HDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLG 226
Query: 789 DAVQVNSTAHEVWNGLGEVLQAQGN-DAAATECFLTALELEASSP 832
+A+ + T ++ G ++Q G+ D A T+ + A + S P
Sbjct: 227 NALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPP 271
Score = 38.1 bits (87), Expect = 0.034
Identities = 17/73 (23%), Positives = 40/73 (54%)
Query: 733 LYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQ 792
+Y++ I L G++ E+ ++ +SP +++++A L LG++ A ++ +A +
Sbjct: 70 IYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAK 129
Query: 793 VNSTAHEVWNGLG 805
+N E+ + LG
Sbjct: 130 LNQKDWEISHNLG 142
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 46.2 bits (108), Expect = 1e-04
Identities = 68/306 (22%), Positives = 120/306 (39%), Gaps = 23/306 (7%)
Query: 533 EALGYVRQALQLQGDDANSLHLLALLL----SAQKHYHDALNIIDMALSEYPENFILLFS 588
EA+ + R AL+L A++L+ L L A+ +Y AL + +P++ LF+
Sbjct: 393 EAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRALQL-------HPQHNRALFN 445
Query: 589 KVKLQSLCRGPDEALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLP 648
L +EA+ K ++ + + S + + Q P
Sbjct: 446 LGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCP 505
Query: 649 DFSDPETGSVHATSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIG 708
D SD +H + V+ L E A + A K P H ++ +Y
Sbjct: 506 DSSD-----LH-NNYGVFLVDTGLPEKAVAHYQQAIKLSPSHH-----VAMVNLGRLYRS 554
Query: 709 IGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQ 768
+G+ + A + A + + +L G + G +EA + Y+EA A+ P+ +
Sbjct: 555 LGENSMAEEWYKRALQVAHKAE-ILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRL 613
Query: 769 RLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELE 828
LA +L +G+ AEK+ V + E + L + Q N A + AL+L+
Sbjct: 614 ALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLK 673
Query: 829 ASSPAV 834
P V
Sbjct: 674 PKDPKV 679
Score = 44.3 bits (103), Expect = 5e-04
Identities = 72/342 (21%), Positives = 142/342 (41%), Gaps = 26/342 (7%)
Query: 499 KALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALL 558
+A + +QRA L P ++A F L L + EA+ ++ +++ + A++ LA L
Sbjct: 424 EAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASL 483
Query: 559 LSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEALLTCKHMLQIWKSCYN 618
L+ Q+ + +A I + P++ L + P++A+ + +++ S ++
Sbjct: 484 LAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPS-HH 542
Query: 619 LTNPSDSGRGSSLLDRTIAD---RRQLNTITLPDFSDPETGSVHATSVAASRVEQALS-- 673
+ + SL + ++A+ +R L + P + A R E+AL
Sbjct: 543 VAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSP----LGALYYNTGRYEEALQIY 598
Query: 674 EVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVL 733
+ A++LQ S ++ L A+V +G+ EA T +
Sbjct: 599 QEAAALQPSQ------------RELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECY 646
Query: 734 YMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALIL-HQLGRYSLAEKIL---RD 789
+ I + + D+A ++AL + P K + L +QL +L +K R
Sbjct: 647 RLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRV 706
Query: 790 AVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASS 831
AVQ+N + W +G + +G +A + AL+L S
Sbjct: 707 AVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDS 748
Score = 43.5 bits (101), Expect = 8e-04
Identities = 53/241 (21%), Positives = 92/241 (38%), Gaps = 25/241 (10%)
Query: 350 EHKSDRLISLQSASV--------VYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWY 401
+ K + I+L S+ Y L L + +++ E + +K + L
Sbjct: 453 QEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHN 512
Query: 402 QFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDV 461
+ + L+ G +AV ++ I+L P + +L SL AE++ K + V
Sbjct: 513 NYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYR-SLGENSMAEEWYKRALQV 571
Query: 462 GEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYL 521
K G L G E +AL +Q A +L P+ + L
Sbjct: 572 AHKAEILSPLGALYYNT------------GRYE----EALQIYQEAAALQPSQRELRLAL 615
Query: 522 ALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPE 581
A LA+ Q EA + + LL+ + S Q+++ AL+ ID AL P+
Sbjct: 616 AQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPK 675
Query: 582 N 582
+
Sbjct: 676 D 676
>gi|7661910 tetratricopeptide repeat domain 35 [Homo sapiens]
Length = 297
Score = 44.3 bits (103), Expect = 5e-04
Identities = 38/152 (25%), Positives = 62/152 (40%), Gaps = 12/152 (7%)
Query: 669 EQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPM 728
E+ ++E AS L W+ Q+ + A + G+ A C QE FP
Sbjct: 38 EELINEYASKLGDDI--------WIIYEQVMIAALDY----GRDDLALFCLQELRRQFPG 85
Query: 729 SHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILR 788
SH V + G E D+A + Y+ L PT+ + +R I G+ A + L
Sbjct: 86 SHRVKRLTGMRFEAMERYDDAIQLYDRILQEDPTNTAARKRKIAIRKAQGKNVEAIRELN 145
Query: 789 DAVQVNSTAHEVWNGLGEVLQAQGNDAAATEC 820
+ ++ E W+ L E+ + + A A C
Sbjct: 146 EYLEQFVGDQEAWHELAELYINEHDYAKAAFC 177
Score = 30.4 bits (67), Expect = 7.2
Identities = 27/134 (20%), Positives = 58/134 (43%), Gaps = 7/134 (5%)
Query: 697 QIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDE---ARRWY 753
+ W AE+YI A+A C +E P +H ++ +G ++ +R+++
Sbjct: 156 EAWHELAELYINEHDYAKAAFCLEELMMTNPHNHLYCQQYAEVKYTQGGLENLELSRKYF 215
Query: 754 EEALAISPTHVKSMQRLAL-ILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQG 812
+AL ++ +++++ L + H + K +D ++ S A + + Q G
Sbjct: 216 AQALKLNNRNMRALFGLYMSASHIASNPKASAKTKKDNMKYASWAA---SQINRAYQFAG 272
Query: 813 NDAAATECFLTALE 826
T+ L A+E
Sbjct: 273 RSKKETKYSLKAVE 286
>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
[Homo sapiens]
Length = 836
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/136 (25%), Positives = 57/136 (41%), Gaps = 3/136 (2%)
Query: 704 EVYIGIGKPAEATACTQEAANLFPMS---HNVLYMRGQIAELRGSMDEARRWYEEALAIS 760
++Y G EA + +EA P ++ M G+ + EA WY E+L
Sbjct: 614 KLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSK 673
Query: 761 PTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATEC 820
H+ + +L GR S AEK+ A++++ T + G+ L + A E
Sbjct: 674 TDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEM 733
Query: 821 FLTALELEASSPAVPF 836
A EL+++ V F
Sbjct: 734 AKKAAELDSTEFDVVF 749
Score = 39.3 bits (90), Expect = 0.015
Identities = 28/132 (21%), Positives = 55/132 (41%), Gaps = 11/132 (8%)
Query: 694 TLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWY 753
T ++H + + + EA ++AA L +V++ + + A ++Y
Sbjct: 709 TKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYY 768
Query: 754 EEALAISPTHVKSMQRLALILHQLGRYSLAE-------KILRDAVQVNSTAHEVWNGLGE 806
+ A + P + ++ L ILH GR AE ++ D V S ++WN
Sbjct: 769 DLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWN---- 824
Query: 807 VLQAQGNDAAAT 818
+++ QG + T
Sbjct: 825 IMEKQGLKTSKT 836
Score = 30.4 bits (67), Expect = 7.2
Identities = 30/142 (21%), Positives = 53/142 (37%), Gaps = 11/142 (7%)
Query: 696 AQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEE 755
A+ W + V K +EA + + A ++LY G + + EA +Y+
Sbjct: 493 AKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKL 552
Query: 756 ALAISPTHVKSMQRLALILHQLGRYSLAEKI-----------LRDAVQVNSTAHEVWNGL 804
A+ PT + +IL GR A + L+D S+ L
Sbjct: 553 AIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNL 612
Query: 805 GEVLQAQGNDAAATECFLTALE 826
G++ QG+ A + A++
Sbjct: 613 GKLYHEQGHYEEALSVYKEAIQ 634
Score = 30.0 bits (66), Expect = 9.4
Identities = 21/72 (29%), Positives = 36/72 (50%), Gaps = 10/72 (13%)
Query: 90 NLKSEFLQESNLI-----MAKLNYVEGDYKEALNIYARVGLDDLPLTAVPPYRLRVIAEA 144
NLK +S++ + KL + +G Y+EAL++Y + + +P P ++ EA
Sbjct: 594 NLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVY-KEAIQKMPRQFAPQSLYNMMGEA 652
Query: 145 YATKGLCLEKLP 156
Y + L KLP
Sbjct: 653 Y----MRLSKLP 660
>gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]
Length = 1564
Score = 40.8 bits (94), Expect = 0.005
Identities = 38/159 (23%), Positives = 65/159 (40%), Gaps = 9/159 (5%)
Query: 649 DFSDPETGSVHAT-SVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYI 707
D +D E+G+ SV +E AL+ + + Q ++ T WL Y+
Sbjct: 524 DDTDAESGAAAVDLSVELEDMEMALAILTTVTQKASAG--------TAKWAWLRRGLYYL 575
Query: 708 GIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSM 767
G+ ++A A Q A P N G+ RG A + + +A ++P + S+
Sbjct: 576 KAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKASELNPESIYSV 635
Query: 768 QRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGE 806
++A I LG+Y A + ++ GLGE
Sbjct: 636 FKVAAIQQILGKYKEAVAQYQMIIKKKEDYVPALKGLGE 674
Score = 31.6 bits (70), Expect = 3.2
Identities = 16/41 (39%), Positives = 22/41 (53%)
Query: 787 LRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALEL 827
L+ V NST+ W L V Q+QG AA C+ +L+L
Sbjct: 1389 LQKTVMSNSTSVPAWQWLAHVYQSQGMMRAAEMCYRKSLQL 1429
>gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo
sapiens]
Length = 515
Score = 39.7 bits (91), Expect = 0.012
Identities = 25/111 (22%), Positives = 52/111 (46%)
Query: 695 LAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYE 754
+ +L+ A+VY+ + +P A ++ + FP +L +I E +M A +Y+
Sbjct: 257 MVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYK 316
Query: 755 EALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLG 805
E L THV+++ + + +A + R +Q+ +++N LG
Sbjct: 317 EVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLG 367
>gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo
sapiens]
Length = 475
Score = 39.7 bits (91), Expect = 0.012
Identities = 25/111 (22%), Positives = 52/111 (46%)
Query: 695 LAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYE 754
+ +L+ A+VY+ + +P A ++ + FP +L +I E +M A +Y+
Sbjct: 217 MVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYK 276
Query: 755 EALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLG 805
E L THV+++ + + +A + R +Q+ +++N LG
Sbjct: 277 EVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLG 327
>gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo
sapiens]
Length = 505
Score = 39.7 bits (91), Expect = 0.012
Identities = 25/111 (22%), Positives = 52/111 (46%)
Query: 695 LAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYE 754
+ +L+ A+VY+ + +P A ++ + FP +L +I E +M A +Y+
Sbjct: 247 MVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYK 306
Query: 755 EALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLG 805
E L THV+++ + + +A + R +Q+ +++N LG
Sbjct: 307 EVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLG 357
>gi|42476022 tetratricopeptide repeat domain 27 [Homo sapiens]
Length = 843
Score = 38.1 bits (87), Expect = 0.034
Identities = 26/113 (23%), Positives = 48/113 (42%), Gaps = 17/113 (15%)
Query: 375 RRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDA--- 431
R +++ EC ER++K + +W+ + +A + K + C+ L+PD+A
Sbjct: 539 RNKEFQECVECFERSVKINPMQLGVWFSLGCAYLALEDYQGSAKAFQRCVTLEPDNAEAW 598
Query: 432 ---TIPLLAAKLCMGSLHWLEEA-----------EKFAKTVVDVGEKTSEFKA 470
+ + K + + L+EA E + T DVGE + KA
Sbjct: 599 NNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKA 651
>gi|226498382 tetratricopeptide repeat domain 5 [Homo sapiens]
Length = 440
Score = 37.7 bits (86), Expect = 0.045
Identities = 20/43 (46%), Positives = 26/43 (60%)
Query: 783 AEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTAL 825
AE++L AV++ E WN LGEV +G+ AAA CF AL
Sbjct: 88 AEELLSKAVKLEPELVEAWNQLGEVYWKKGDVAAAHTCFSGAL 130
>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
sapiens]
Length = 830
Score = 37.7 bits (86), Expect = 0.045
Identities = 25/117 (21%), Positives = 50/117 (42%)
Query: 720 QEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGR 779
Q A + P + G L +D+A + A+ ++P H + L +I ++ +
Sbjct: 597 QRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEK 656
Query: 780 YSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPF 836
+SLAE + A+ +N + + +G V A A + A+ ++ +P F
Sbjct: 657 FSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKF 713
Score = 30.8 bits (68), Expect = 5.5
Identities = 19/81 (23%), Positives = 36/81 (44%)
Query: 714 EATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALI 773
+A AC + A + P +N Y G I + A +++AL I+P + + ++
Sbjct: 625 KALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVV 684
Query: 774 LHQLGRYSLAEKILRDAVQVN 794
H L + A L A+ ++
Sbjct: 685 QHALKKSEKALDTLNKAIVID 705
>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
sapiens]
Length = 824
Score = 37.7 bits (86), Expect = 0.045
Identities = 25/117 (21%), Positives = 50/117 (42%)
Query: 720 QEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGR 779
Q A + P + G L +D+A + A+ ++P H + L +I ++ +
Sbjct: 591 QRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEK 650
Query: 780 YSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPF 836
+SLAE + A+ +N + + +G V A A + A+ ++ +P F
Sbjct: 651 FSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKF 707
Score = 30.8 bits (68), Expect = 5.5
Identities = 19/81 (23%), Positives = 36/81 (44%)
Query: 714 EATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALI 773
+A AC + A + P +N Y G I + A +++AL I+P + + ++
Sbjct: 619 KALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVV 678
Query: 774 LHQLGRYSLAEKILRDAVQVN 794
H L + A L A+ ++
Sbjct: 679 QHALKKSEKALDTLNKAIVID 699
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 37.0 bits (84), Expect = 0.077
Identities = 79/410 (19%), Positives = 149/410 (36%), Gaps = 35/410 (8%)
Query: 416 AVKVLKECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKGYLA 475
A+ K+ +R P L C L+ LE+A +++ K
Sbjct: 182 ALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKARLAFSRALELNSK----------C 231
Query: 476 LGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEAL 535
+G L + + + + LL+ RA+++ P++ +LA + +
Sbjct: 232 VGALVGLAVLELNNKEADSIKNGVQLLS--RAYTIDPSNPMVLNHLANHFFFKKDYSKVQ 289
Query: 536 GYVRQAL---QLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKL 592
A +++ A S + LA Q+ Y A A +F+L F +
Sbjct: 290 HLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQFASSSFVLPFFGLGQ 349
Query: 593 QSLCRGPDEALLTC-KHMLQIWKSCYNLTNPSDSGRGSS--LLDRTIADRRQLNTITLPD 649
+ RG E C + +L+ + + Y S +S R IA + L +T
Sbjct: 350 MYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIA-KGHLKKVTEQY 408
Query: 650 FSDPETGSVHATSVAASRVEQALSEVASS-------LQSSAPKQ-----GPLHPWMTLAQ 697
D E A + + ++ ALS ++ +Q+ P + G LH L
Sbjct: 409 PDDVEAWIELAQILEQTDIQGALSAYGTATRILQEKVQADVPPEILNNVGALH--FRLGN 466
Query: 698 IWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEAL 757
+ A + ++ A+A A + +S Y ++ E EA + Y+ L
Sbjct: 467 LG-EAKKYFLASLDRAKAEA-EHDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNIL 524
Query: 758 AISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEV 807
P +V RL + G + A ++A+Q+N + W+ +G +
Sbjct: 525 REHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNL 574
Score = 31.6 bits (70), Expect = 3.2
Identities = 27/121 (22%), Positives = 55/121 (45%), Gaps = 9/121 (7%)
Query: 695 LAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHN---VLYMRGQIAELRGSMDEARR 751
++ +WL+ A +Y+ + A + F N VLY+ + + G + E ++
Sbjct: 680 ISDVWLNLAHIYVEQKQYISAVQMYENCLRKFYKHQNTEVVLYLARALFKC-GKLQECKQ 738
Query: 752 WYEEALAISPTHVKSMQRLALILHQLGRYSLAE-----KILRDAVQVNSTAHEVWNGLGE 806
+A ++P+ M +AL+L +L L + K + +AV+ AH ++ L +
Sbjct: 739 TLLKARHVAPSDTVLMFNVALVLQRLATSVLKDEKSNLKEVLNAVKELELAHRYFSYLSK 798
Query: 807 V 807
V
Sbjct: 799 V 799
>gi|224809432 transmembrane and tetratricopeptide repeat containing
3 [Homo sapiens]
Length = 914
Score = 35.8 bits (81), Expect = 0.17
Identities = 51/232 (21%), Positives = 93/232 (40%), Gaps = 56/232 (24%)
Query: 407 LMAAGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTS 466
+MA + + K R+ P+ + + A L + LEEA++ + + +
Sbjct: 504 MMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFK 563
Query: 467 E-FKAKGYLALGLTYSLQATDASLRGMQ-----------------EVLQ-RKALLAFQRA 507
+ + ++G L L + L+A +A L+ ++ E+ + +AL F RA
Sbjct: 564 QAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRA 623
Query: 508 HSLSPTDHQAAFYLALQLAISRQI---PEA----LGYV---------------------- 538
L+P A F A+ + S ++ PEA L Y+
Sbjct: 624 LELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKK 683
Query: 539 --------RQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPEN 582
++A++LQ D ++L LALL S AL I++ L YP++
Sbjct: 684 DNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDH 735
Score = 33.1 bits (74), Expect = 1.1
Identities = 22/77 (28%), Positives = 36/77 (46%), Gaps = 1/77 (1%)
Query: 756 ALAISPTHVKSMQRLA-LILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGND 814
A I+P H+ LA LI R A+++ R A+ + + + GE+L
Sbjct: 520 AARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKP 579
Query: 815 AAATECFLTALELEASS 831
A E +L ALEL+ ++
Sbjct: 580 LKAKEAYLKALELDRNN 596
Score = 30.4 bits (67), Expect = 7.2
Identities = 25/106 (23%), Positives = 47/106 (44%), Gaps = 1/106 (0%)
Query: 727 PMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKI 786
P+ N + G +A +EA W ++A+ + ++ LAL+ Q + A I
Sbjct: 665 PLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPI 724
Query: 787 LRDAVQVNSTAHEVWNGLGEVLQAQGND-AAATECFLTALELEASS 831
L + ++ + G++L Q D A +CF LE++ S+
Sbjct: 725 LEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSN 770
>gi|118402596 cell division cycle protein 23 [Homo sapiens]
Length = 597
Score = 35.8 bits (81), Expect = 0.17
Identities = 17/73 (23%), Positives = 36/73 (49%)
Query: 737 GQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNST 796
G LR ++A +++ AL ++P ++ + + ++ S A + R A++VN
Sbjct: 338 GNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKR 397
Query: 797 AHEVWNGLGEVLQ 809
+ W GLG+ +
Sbjct: 398 DYRAWYGLGQTYE 410
>gi|17149828 NMDA receptor regulated 1 [Homo sapiens]
Length = 866
Score = 35.8 bits (81), Expect = 0.17
Identities = 26/109 (23%), Positives = 48/109 (44%), Gaps = 7/109 (6%)
Query: 687 GPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSM 746
G P TL + + A+ Y IG+P+ A A P + ++ +I + G++
Sbjct: 365 GKEEPPTTLLWVQYYLAQHYDKIGQPSIALEYINTAIESTPTLIELFLVKAKIYKHAGNI 424
Query: 747 DEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNS 795
EA RW +EA A+ I + +Y L ++++A ++ S
Sbjct: 425 KEAARWMDEAQALDTAD-------RFINSKCAKYMLKANLIKEAEEMCS 466
>gi|118402578 anaphase-promoting complex, subunit 6 [Homo sapiens]
Length = 620
Score = 35.4 bits (80), Expect = 0.22
Identities = 36/143 (25%), Positives = 58/143 (40%), Gaps = 9/143 (6%)
Query: 694 TLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWY 753
T W+ + + +A A AA L H + G L + A R++
Sbjct: 332 TYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFF 391
Query: 754 EEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQ-VNSTAHEV----W----NGL 804
+AL+I+P M + ++ Q G + AEK DA++ + + +EV W N L
Sbjct: 392 SQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNL 451
Query: 805 GEVLQAQGNDAAATECFLTALEL 827
G V + A A + AL L
Sbjct: 452 GHVCRKLKKYAEALDYHRQALVL 474
>gi|118402580 anaphase-promoting complex, subunit 6 [Homo sapiens]
Length = 620
Score = 35.4 bits (80), Expect = 0.22
Identities = 36/143 (25%), Positives = 58/143 (40%), Gaps = 9/143 (6%)
Query: 694 TLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWY 753
T W+ + + +A A AA L H + G L + A R++
Sbjct: 332 TYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFF 391
Query: 754 EEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQ-VNSTAHEV----W----NGL 804
+AL+I+P M + ++ Q G + AEK DA++ + + +EV W N L
Sbjct: 392 SQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNL 451
Query: 805 GEVLQAQGNDAAATECFLTALEL 827
G V + A A + AL L
Sbjct: 452 GHVCRKLKKYAEALDYHRQALVL 474
>gi|229577238 tetratricopeptide repeat domain 18 [Homo sapiens]
Length = 1121
Score = 34.7 bits (78), Expect = 0.38
Identities = 18/67 (26%), Positives = 33/67 (49%)
Query: 748 EARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEV 807
+A+ +++AL+++ +H+ S+ ++ L Y AE DA + T W LG
Sbjct: 687 KAQECFQKALSLNQSHIHSLLLCGVLAVLLENYEQAEIFFEDATCLEPTNVVAWTLLGLY 746
Query: 808 LQAQGND 814
+ Q ND
Sbjct: 747 YEIQNND 753
Score = 33.9 bits (76), Expect = 0.65
Identities = 32/113 (28%), Positives = 53/113 (46%), Gaps = 6/113 (5%)
Query: 697 QIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEA 756
+ +L A+ +I A+A Q+AA + ++ NV ++G + L G+ EA+ YE
Sbjct: 930 EYYLVLAQTHILKKNFAKAEEYLQQAAQMDYLNPNVWGLKGHLYFLSGNHSEAKACYERT 989
Query: 757 LAI----SPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLG 805
++ S H + RL LI + Y A+K A + S + W GLG
Sbjct: 990 ISFVVDASEMHFIFL-RLGLIYLEEKEYEKAKKTYMQACK-RSPSCLTWLGLG 1040
Score = 30.4 bits (67), Expect = 7.2
Identities = 31/144 (21%), Positives = 61/144 (42%), Gaps = 15/144 (10%)
Query: 714 EATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQ----- 768
+A C Q+A +L + L + G +A L + ++A ++E+A + PT+V +
Sbjct: 687 KAQECFQKALSLNQSHIHSLLLCGVLAVLLENYEQAEIFFEDATCLEPTNVVAWTLLGLY 746
Query: 769 --------RLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATEC 820
R+ + H+ + A + + ST E G+ + G T
Sbjct: 747 YEIQNNDIRMEMAFHEASKQLQARMLQAQVTKQKSTGVEDTEERGKRESSLG-PWGITNG 805
Query: 821 FLTALELEA-SSPAVPFTIIPRVL 843
TA+++EA + P +I+ + L
Sbjct: 806 SATAIKVEAPAGPGAALSILDKFL 829
>gi|157502179 tetratricopeptide repeat domain 21A isoform 1 [Homo
sapiens]
Length = 1321
Score = 34.7 bits (78), Expect = 0.38
Identities = 21/94 (22%), Positives = 45/94 (47%)
Query: 499 KALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALL 558
KA+ +++ S PTD++ LA + + + LQ + + + L+A L
Sbjct: 908 KAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADL 967
Query: 559 LSAQKHYHDALNIIDMALSEYPENFILLFSKVKL 592
+ ++ + A+N+ L + P+NF++L + L
Sbjct: 968 MFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDL 1001
>gi|157502177 tetratricopeptide repeat domain 21A isoform 2 [Homo
sapiens]
Length = 1320
Score = 34.7 bits (78), Expect = 0.38
Identities = 21/94 (22%), Positives = 45/94 (47%)
Query: 499 KALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALL 558
KA+ +++ S PTD++ LA + + + LQ + + + L+A L
Sbjct: 907 KAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADL 966
Query: 559 LSAQKHYHDALNIIDMALSEYPENFILLFSKVKL 592
+ ++ + A+N+ L + P+NF++L + L
Sbjct: 967 MFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDL 1000
>gi|21361787 tetratricopeptide repeat domain 17 [Homo sapiens]
Length = 1141
Score = 34.7 bits (78), Expect = 0.38
Identities = 36/140 (25%), Positives = 52/140 (37%), Gaps = 35/140 (25%)
Query: 696 AQIWL---HAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRW 752
A IWL A + +G A AC Q A NL P+
Sbjct: 616 APIWLILNEAGLYWRAVGNSTFAIACLQRALNLAPLQ----------------------- 652
Query: 753 YEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQG 812
Y++ ++ LA +L G + A K+L A+ +NS+ + LG A
Sbjct: 653 YQDVPLVN---------LANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALK 703
Query: 813 NDAAATECFLTALELEASSP 832
N + A E F AL+L P
Sbjct: 704 NISGALEAFRQALKLTTKCP 723
>gi|109638749 signal recognition particle 72kDa [Homo sapiens]
Length = 671
Score = 34.3 bits (77), Expect = 0.50
Identities = 55/252 (21%), Positives = 94/252 (37%), Gaps = 42/252 (16%)
Query: 534 ALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQ 593
AL V + LQ+ DD +LH + L + +ALN+I+ N L F K +
Sbjct: 30 ALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANN-SLSFEKAYCE 88
Query: 594 SLCRGPDEALLTCKHMLQIWKSCYNLTNPSDSGRGSSL-----LDRTIADRRQLNTITLP 648
+ AL T +S T+ G L D +A R L +
Sbjct: 89 YRLNRIENALKTI-------ESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQD 141
Query: 649 DFSDPETGSVHATSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIG 708
D+ + ++ A A S E+ + E + + ++ + A IG
Sbjct: 142 DYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGT-------------HELCYNTACALIG 188
Query: 709 IGKPAEATACTQEAANLFPMS-------------HNVLYMRGQIA---ELRGSMDEARRW 752
G+ +A Q+A +L S + + GQ+A +L+G +EA +
Sbjct: 189 QGQLNQAMKILQKAEDLCRRSLSEDTDGTEEDPQAELAIIHGQMAYILQLQGRTEEALQL 248
Query: 753 YEEALAISPTHV 764
Y + + + PT V
Sbjct: 249 YNQIIKLKPTDV 260
>gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens]
Length = 1316
Score = 32.7 bits (73), Expect = 1.4
Identities = 18/75 (24%), Positives = 37/75 (49%)
Query: 478 LTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGY 537
L Y++ + G +++ +K +RA SL+P + A L Q+ + ++ EAL +
Sbjct: 287 LFYNITLAFSRTCGRSQLILQKIQTLLERAFSLNPQQSEFATELGYQMILQGRVKEALKW 346
Query: 538 VRQALQLQGDDANSL 552
+ A+ L ++L
Sbjct: 347 YKTAMTLDETSVSAL 361
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,749,104
Number of Sequences: 37866
Number of extensions: 1240615
Number of successful extensions: 4166
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 46
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 3932
Number of HSP's gapped (non-prelim): 224
length of query: 843
length of database: 18,247,518
effective HSP length: 111
effective length of query: 732
effective length of database: 14,044,392
effective search space: 10280494944
effective search space used: 10280494944
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.