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Search of human proteins with 58331189
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
[Homo sapiens]
(626 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ... 1247 0.0
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 1247 0.0
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap... 497 e-140
gi|71274148 pleckstrin homology domain containing, family G (wit... 114 2e-25
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 108 1e-23
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 108 1e-23
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 103 5e-22
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 102 8e-22
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 98 3e-20
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 94 3e-19
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 94 3e-19
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 94 5e-19
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom... 92 2e-18
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 88 2e-17
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo... 86 8e-17
gi|39930351 dynamin binding protein [Homo sapiens] 85 2e-16
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 84 3e-16
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 84 3e-16
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 81 3e-15
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 80 6e-15
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 80 6e-15
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 79 1e-14
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 79 1e-14
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 79 1e-14
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 79 1e-14
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 79 1e-14
gi|21735572 epithelial cell transforming sequence 2 oncogene pro... 79 1e-14
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom... 78 2e-14
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom... 78 2e-14
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom... 78 2e-14
>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
[Homo sapiens]
Length = 626
Score = 1247 bits (3227), Expect = 0.0
Identities = 626/626 (100%), Positives = 626/626 (100%)
Query: 1 MEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFL 60
MEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFL
Sbjct: 1 MEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFL 60
Query: 61 TQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA 120
TQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA
Sbjct: 61 TQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA 120
Query: 121 DHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKY 180
DHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKY
Sbjct: 121 DHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKY 180
Query: 181 PLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTE 240
PLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTE
Sbjct: 181 PLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTE 240
Query: 241 KEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPS 300
KEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPS
Sbjct: 241 KEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPS 300
Query: 301 NSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQL 360
NSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQL
Sbjct: 301 NSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQL 360
Query: 361 CCSDSESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSL 420
CCSDSESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSL
Sbjct: 361 CCSDSESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSL 420
Query: 421 KVLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLA 480
KVLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLA
Sbjct: 421 KVLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLA 480
Query: 481 DFADNLIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPES 540
DFADNLIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPES
Sbjct: 481 DFADNLIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPES 540
Query: 541 GEGQKGGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLE 600
GEGQKGGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLE
Sbjct: 541 GEGQKGGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLE 600
Query: 601 REFSVQSLTSVVSEECFYETESHGKS 626
REFSVQSLTSVVSEECFYETESHGKS
Sbjct: 601 REFSVQSLTSVVSEECFYETESHGKS 626
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
sapiens]
Length = 1701
Score = 1247 bits (3227), Expect = 0.0
Identities = 626/626 (100%), Positives = 626/626 (100%)
Query: 1 MEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFL 60
MEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFL
Sbjct: 1076 MEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFL 1135
Query: 61 TQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA 120
TQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA
Sbjct: 1136 TQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA 1195
Query: 121 DHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKY 180
DHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKY
Sbjct: 1196 DHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKY 1255
Query: 181 PLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTE 240
PLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTE
Sbjct: 1256 PLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTE 1315
Query: 241 KEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPS 300
KEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPS
Sbjct: 1316 KEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPS 1375
Query: 301 NSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQL 360
NSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQL
Sbjct: 1376 NSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQL 1435
Query: 361 CCSDSESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSL 420
CCSDSESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSL
Sbjct: 1436 CCSDSESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSL 1495
Query: 421 KVLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLA 480
KVLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLA
Sbjct: 1496 KVLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLA 1555
Query: 481 DFADNLIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPES 540
DFADNLIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPES
Sbjct: 1556 DFADNLIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPES 1615
Query: 541 GEGQKGGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLE 600
GEGQKGGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLE
Sbjct: 1616 GEGQKGGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLE 1675
Query: 601 REFSVQSLTSVVSEECFYETESHGKS 626
REFSVQSLTSVVSEECFYETESHGKS
Sbjct: 1676 REFSVQSLTSVVSEECFYETESHGKS 1701
>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
Length = 1591
Score = 497 bits (1280), Expect = e-140
Identities = 284/524 (54%), Positives = 359/524 (68%), Gaps = 25/524 (4%)
Query: 11 PPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFG 70
P R LSDAD+LRKVI EL++TE++YVKDL+CL E YL+PLQ ETFLTQDE++ LFG
Sbjct: 1027 PQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFG 1086
Query: 71 SLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFC 130
+L EM+EFQ FL+TLEDG+ D LE QF+K+LFSLGGSFLYYAD FKLYS FC
Sbjct: 1087 NLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFC 1146
Query: 131 ANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSL 190
A+H KV KVL +AKTD AFKAFLDA+NP +QHSSTLESYLIKP+QR+LKYPLLL+EL +L
Sbjct: 1147 ASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFAL 1206
Query: 191 TDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGE 250
TD ESEEHYHL A+K M KVASHINEMQKI+E++G VFDQL+AEQ+G +KEV +LSMG+
Sbjct: 1207 TDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVADLSMGD 1266
Query: 251 LLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNSTD 310
LL+H+TV WLNP SLGK +K+ EL FVFK AV+LVYK+ K KKKL + R + D
Sbjct: 1267 LLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRLSIYE-D 1325
Query: 311 LDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTN 370
DPF+FR +IP ALQVR A E N++ E++H KSE EGRPE +F LCCS ES+ +
Sbjct: 1326 WDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSESEGRPERVFHLCCSSPESRKD 1385
Query: 371 IVKVIRSILRENFRRH-IKCE-LPLEKTC----KDRLVPLKNRVPVSAKLAS--SRSL-K 421
+K + SILR+ RR +K E LP + RL LK P ++ S S+SL +
Sbjct: 1386 FLKAVHSILRDKHRRQLLKTESLPSSQQYVPFGGKRLCALKGARPAMSRAVSAPSKSLGR 1445
Query: 422 VLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLAD 481
+ + N +T +DSD S SS + S P G T LA
Sbjct: 1446 RRRRLARNRFT--------IDSDAVSASSPEKESQQPPGGG-----DTDRWVEEQFDLAQ 1492
Query: 482 FAD-NLIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISE 524
+ + + IKE+DILSD DD+ ++VK S +D++ + Q IS+
Sbjct: 1493 YEEQDDIKETDILSD-DDEFCESVKGASVDRDLQERLQATSISQ 1535
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 114 bits (286), Expect = 2e-25
Identities = 78/267 (29%), Positives = 141/267 (52%), Gaps = 29/267 (10%)
Query: 27 KVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLT--QDEMESLFGSLPEMLEFQKVFLE 84
+V+QE+++TE++YV+DL + E YL+ ++++T L +E +LFG++ ++ F L+
Sbjct: 116 RVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQ 175
Query: 85 TLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAK 144
LE N P ++ F+ ++ F +Y+ +C N+ + VL
Sbjct: 176 DLE---------NCENDP-------VAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECM 219
Query: 145 TDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEA 204
+K F R T +HS L SYL+KPVQR+LKY LLL E+ + D+++E + + +A
Sbjct: 220 RNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDA 279
Query: 205 LKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFL 264
+ M++VA HIN+M++ +E V Q + K S GEL++ T
Sbjct: 280 IDTMQRVAWHINDMKRKHEH--AVRLQEIQSLLTNWKGPDLTSYGELVLEGT-------F 330
Query: 265 SLGKARKDLELTVFVFKRAVILVYKEN 291
+ +A+ E T+F+F + +++ K +
Sbjct: 331 RIQRAKN--ERTLFLFDKLLLITKKRD 355
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 108 bits (271), Expect = 1e-23
Identities = 100/380 (26%), Positives = 176/380 (46%), Gaps = 40/380 (10%)
Query: 16 ARHLSDADRLRK-VIQELVDTEKSYVKDLSCLFELYLEPLQN------ETFLTQDEMESL 68
A+ L RLR V+ EL TE+ YV L L +L + + +T++ ++ L
Sbjct: 14 AKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKML 73
Query: 69 FGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSG 128
F ++ ++L K FL+ +E+ + + +G FL++ D F++Y
Sbjct: 74 FSNIEDILAVHKEFLKVVEECLHPEPNAQQ------------EVGTCFLHFKDKFRIYDE 121
Query: 129 FCANHIKVQKVLERAKTDKAFKAFL---DARNPTKQHSSTLESYLIKPVQRVLKYPLLLK 185
+C+NH K QK+L + + FL K LE YL+ P+QR+ KYPL+LK
Sbjct: 122 YCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILK 181
Query: 186 ELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTE 245
EL+ T ++ ++ + EAL+AM+ V S+INE ++ E V ++ + G E
Sbjct: 182 ELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKL-EVLEEWQSHIEGWEGSNIT 240
Query: 246 LSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPA 305
+ E+LM + +S G + E F+F +LVY CK K + NS+
Sbjct: 241 DTCTEMLMCGVLL----KISSGNIQ---ERVFFLFDN--LLVY---CKRKHRRLKNSKA- 287
Query: 306 HNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDS 365
STD + FR I ++V + + +S ++ +I + + +C + +
Sbjct: 288 --STDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKT 345
Query: 366 ESKTNIVKVIRSILRENFRR 385
+ + + +IL+E RR
Sbjct: 346 PEEKH--EWFEAILKERERR 363
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 108 bits (271), Expect = 1e-23
Identities = 100/380 (26%), Positives = 176/380 (46%), Gaps = 40/380 (10%)
Query: 16 ARHLSDADRLRK-VIQELVDTEKSYVKDLSCLFELYLEPLQN------ETFLTQDEMESL 68
A+ L RLR V+ EL TE+ YV L L +L + + +T++ ++ L
Sbjct: 14 AKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKML 73
Query: 69 FGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSG 128
F ++ ++L K FL+ +E+ + + +G FL++ D F++Y
Sbjct: 74 FSNIEDILAVHKEFLKVVEECLHPEPNAQQ------------EVGTCFLHFKDKFRIYDE 121
Query: 129 FCANHIKVQKVLERAKTDKAFKAFL---DARNPTKQHSSTLESYLIKPVQRVLKYPLLLK 185
+C+NH K QK+L + + FL K LE YL+ P+QR+ KYPL+LK
Sbjct: 122 YCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILK 181
Query: 186 ELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTE 245
EL+ T ++ ++ + EAL+AM+ V S+INE ++ E V ++ + G E
Sbjct: 182 ELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKL-EVLEEWQSHIEGWEGSNIT 240
Query: 246 LSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPA 305
+ E+LM + +S G + E F+F +LVY CK K + NS+
Sbjct: 241 DTCTEMLMCGVLL----KISSGNIQ---ERVFFLFDN--LLVY---CKRKHRRLKNSKA- 287
Query: 306 HNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDS 365
STD + FR I ++V + + +S ++ +I + + +C + +
Sbjct: 288 --STDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKT 345
Query: 366 ESKTNIVKVIRSILRENFRR 385
+ + + +IL+E RR
Sbjct: 346 PEEKH--EWFEAILKERERR 363
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 103 bits (257), Expect = 5e-22
Identities = 104/388 (26%), Positives = 172/388 (44%), Gaps = 39/388 (10%)
Query: 10 PPPRPLARHLSDADRLRK-VIQELVDTEKSYVKDLSCLFELYLEPLQN------ETFLTQ 62
P P AR RLR V+ E++ TE+ YV L L +L ++ E LT+
Sbjct: 34 PGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTE 93
Query: 63 DEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADH 122
+ ++ LF ++ ++LE K FL LE + E SQ LG FL + D
Sbjct: 94 ENVKVLFSNIEDILEVHKDFLAALEYCLHP-------EPQSQHE-----LGNVFLKFKDK 141
Query: 123 FKLYSGFCANHIKVQKVLERAKTDKAFKAFLDA---RNPTKQHSSTLESYLIKPVQRVLK 179
F +Y +C+NH K ++L +AFL + K LE YL+ P+QR+ K
Sbjct: 142 FCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICK 201
Query: 180 YPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGT 239
YPLLLKEL T + +H + AL+AM+ V S+INE ++ E +QL + G
Sbjct: 202 YPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKL-EALEQLQSHIEGW 260
Query: 240 EKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLP 299
E +LL+ T+ ++ A E F+F +LVY CK K ++
Sbjct: 261 EGSNLTDICTQLLLQGTLLKIS-------AGNIQERAFFLFDN--LLVY---CKRKSRVT 308
Query: 300 SNSRPAHNSTDLDP--FKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETI 357
+ + + ++ + FR I ++V + +S + +I +
Sbjct: 309 GSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNK 368
Query: 358 FQLCCSDSESKTNIVKVIRSILRENFRR 385
+ +C + + + K + +I+RE +R
Sbjct: 369 WFVCMAKTAEEKQ--KWLDAIIREREQR 394
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 102 bits (255), Expect = 8e-22
Identities = 78/299 (26%), Positives = 144/299 (48%), Gaps = 29/299 (9%)
Query: 2 EGPRENQDPPPRP------LARHLSDADRLR-KVIQELVDTEKSYVKDLSCLFELYLEPL 54
EGP + Q+ P L R L + D++R VI E++ TE+ Y+K L + E YL+
Sbjct: 74 EGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQC 133
Query: 55 QNETFLTQDE-MESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLG 113
+ + DE ++ +FG++ ++ FQ F+ LE +N + P L +G
Sbjct: 134 RKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLE------KQYNN-DDPH-----LSEIG 181
Query: 114 GSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSS-TLESYLIK 172
FL + D F +YS +C NH+ L + D ++ F +A +Q ++ +L+
Sbjct: 182 PCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLT 241
Query: 173 PVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQL 232
PVQ++ KYPL L EL+ T Q+ ++ ++ AL M V INE ++ E+ +
Sbjct: 242 PVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQ 301
Query: 233 VAEQSGTEKEVTELSMGELLMHSTVSWL-NPFLSLGKARKDLELTVFVFKRAVILVYKE 290
+ +++ + S EL+ ++W+ P+ ++ + F+F ++L K+
Sbjct: 302 ASVLDWEGEDILDRS-SELIYTGEMAWIYQPY------GRNQQRVFFLFDHQMVLCKKD 353
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 97.8 bits (242), Expect = 3e-20
Identities = 78/291 (26%), Positives = 136/291 (46%), Gaps = 23/291 (7%)
Query: 4 PRENQDPPP-RPLARHLSDADRLR-KVIQELVDTEKSYVKDLSCLFELYLEPLQNET-FL 60
P E QD + RH + ++R VI+E++DTE+ Y+K L + E Y+ + T
Sbjct: 218 PSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMF 277
Query: 61 TQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA 120
T ++ ++FG++ ++ +FQ+ FL+ LE +N E L +G FL
Sbjct: 278 TVAQLATIFGNIEDIYKFQRKFLKDLE------KQYNKEEPH------LSEIGSCFLQNQ 325
Query: 121 DHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSS-TLESYLIKPVQRVLK 179
+ F +YS +C NH L ++ F +A +Q ++ +L+ PVQ++ K
Sbjct: 326 EGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICK 385
Query: 180 YPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGT 239
YPL L EL+ T QE ++ ++ A +AM+ VA INE ++ E + V+
Sbjct: 386 YPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWE 445
Query: 240 EKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKE 290
++ L L+HS + K K + T F+F ++ K+
Sbjct: 446 GLDI--LDRSSELIHS-----GELTKITKQGKSQQRTFFLFDHQLVSCKKD 489
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 94.4 bits (233), Expect = 3e-19
Identities = 73/252 (28%), Positives = 119/252 (47%), Gaps = 32/252 (12%)
Query: 5 RENQDPPP---RPLARHL----------SDADRLR-KVIQELVDTEKSYVKDLSCLFELY 50
R NQD P PLA + S D++R VI E++ TE+ Y+K L + E Y
Sbjct: 251 RVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGY 310
Query: 51 LEPLQNET-FLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLL 109
+ + +++++ ++FG++ ++ QK F++ LE + R L
Sbjct: 311 VRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRE------------RPHL 358
Query: 110 FSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDA-RNPTKQHSSTLES 168
LG FL + F++YS +C NH L R + F +A R K +L+
Sbjct: 359 SELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDG 418
Query: 169 YLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTV 228
+L+ PVQ++ KYPL L EL+ T + + + AL AM+ VA INE ++ E+
Sbjct: 419 FLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLEN---- 474
Query: 229 FDQLVAEQSGTE 240
D++ QS E
Sbjct: 475 IDKIAQWQSSIE 486
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 94.4 bits (233), Expect = 3e-19
Identities = 73/252 (28%), Positives = 119/252 (47%), Gaps = 32/252 (12%)
Query: 5 RENQDPPP---RPLARHL----------SDADRLR-KVIQELVDTEKSYVKDLSCLFELY 50
R NQD P PLA + S D++R VI E++ TE+ Y+K L + E Y
Sbjct: 251 RVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGY 310
Query: 51 LEPLQNET-FLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLL 109
+ + +++++ ++FG++ ++ QK F++ LE + R L
Sbjct: 311 VRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRE------------RPHL 358
Query: 110 FSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDA-RNPTKQHSSTLES 168
LG FL + F++YS +C NH L R + F +A R K +L+
Sbjct: 359 SELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDG 418
Query: 169 YLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTV 228
+L+ PVQ++ KYPL L EL+ T + + + AL AM+ VA INE ++ E+
Sbjct: 419 FLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLEN---- 474
Query: 229 FDQLVAEQSGTE 240
D++ QS E
Sbjct: 475 IDKIAQWQSSIE 486
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 93.6 bits (231), Expect = 5e-19
Identities = 67/225 (29%), Positives = 111/225 (49%), Gaps = 29/225 (12%)
Query: 11 PPRPLARHLSDA--------DRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFL-- 60
P P+ HLS RL +V +E+V+TE++YV+DL + E YL PL + L
Sbjct: 81 PGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGL 140
Query: 61 TQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA 120
+ +++ +LF ++ ++ EF LE LE+ SA + F+ +
Sbjct: 141 SVEQVGTLFANIEDIYEFSSELLEDLENSSSAGG-----------------IAECFVQRS 183
Query: 121 DHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKY 180
+ F +Y+ +C N+ +L +L R +HS L+S+L+KPVQR+LKY
Sbjct: 184 EDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRILKY 243
Query: 181 PLLLKELVS--LTDQESEEHYHLTEALKAMEKVASHINEMQKIYE 223
LLL+EL + + EA+ +M VA +IN+M++ E
Sbjct: 244 HLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQE 288
>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
sapiens]
Length = 2063
Score = 91.7 bits (226), Expect = 2e-18
Identities = 84/358 (23%), Positives = 150/358 (41%), Gaps = 29/358 (8%)
Query: 2 EGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPL---QNET 58
E R +P P D + V L+DTE+SYV+ L L + Y++PL +N
Sbjct: 1044 EAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV 1103
Query: 59 FLTQDEMESLFGSLPEMLEFQKVFLETLEDGIS---ASSDFNTLETPSQFRKLLFSLGGS 115
++ +F +PE+LE + FLE + + A L S + +L ++
Sbjct: 1104 LCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNI--- 1160
Query: 116 FLYYADHFKLYSGFCANHIKVQKVLERAKTDK-AFKAFLDARNPTKQHSSTLESYLIKPV 174
YS + N + + + AK + AF FL+ + L +IKPV
Sbjct: 1161 ----------YSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPV 1210
Query: 175 QRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYED---YGTVFDQ 231
QR+ +Y LL+K+L+ T ++ +H L EA + +++VA IN+ + E+ + V +
Sbjct: 1211 QRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQE 1270
Query: 232 LVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKEN 291
+ A G E + + L V + ++G +KD L +F + +++
Sbjct: 1271 IEAHIEGMED--LQAPLRRFLRQEMVIEVK---AIG-GKKDRSLFLFTDLIVCTTLKRKS 1324
Query: 292 CKLKKKLPSNSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSE 349
L++ S A +K W +P+ + G T +I + I E
Sbjct: 1325 GSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDE 1382
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 88.2 bits (217), Expect = 2e-17
Identities = 77/278 (27%), Positives = 138/278 (49%), Gaps = 29/278 (10%)
Query: 19 LSDADRLRK-VIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLE 77
L+ +R R+ I EL+ TE++YV DL + E++ +PL LT+ E+ +F + E++
Sbjct: 1231 LTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIM 1290
Query: 78 FQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQ 137
L+ L S + ++ +G H + Y FC+ +
Sbjct: 1291 CNIKLLKALRVRKKMSGEKMPVKM----------IGDILSAQLPHMQPYIRFCSRQLNGA 1340
Query: 138 KVLERAKTDKA--FKAFLD--ARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQ 193
++++ KTD+A FK F+ A +P + L S+++KP+QRV +YPL++K ++ T +
Sbjct: 1341 ALIQQ-KTDEAPDFKEFVKRLAMDP-RCKGMPLSSFILKPMQRVTRYPLIIKNILENTPE 1398
Query: 194 ESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLM 253
+H HL AL+ E++ S +NE + E+ D+L Q+ + E +L+
Sbjct: 1399 NHPDHSHLKHALEKAEELCSQVNEGVREKEN----SDRLEWIQAHVQCEGLS---EQLVF 1451
Query: 254 HSTVSWLNP--FLSLG---KARKDLELTVFVFKRAVIL 286
+S + L P FL G KA+ + EL F+F ++L
Sbjct: 1452 NSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLL 1489
>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
sapiens]
Length = 776
Score = 86.3 bits (212), Expect = 8e-17
Identities = 56/194 (28%), Positives = 93/194 (47%), Gaps = 16/194 (8%)
Query: 28 VIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLE 87
V+Q ++DTEK Y K+L L YL PLQ+ L+ E+ SL G+ E+ FQ+ + LE
Sbjct: 245 VLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALE 304
Query: 88 DGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGFCANHIKVQKVLERAKTD 146
+ S+F + +GG L HFK +Y +CANH VL + +
Sbjct: 305 E-------------CSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDE 351
Query: 147 KAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALK 206
+ F++ + + L + L KP R+ KY LL+EL + +H + +A+
Sbjct: 352 --LEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIV 409
Query: 207 AMEKVASHINEMQK 220
A + + +++K
Sbjct: 410 AFKTLMGQCQDLRK 423
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 85.1 bits (209), Expect = 2e-16
Identities = 69/249 (27%), Positives = 121/249 (48%), Gaps = 39/249 (15%)
Query: 23 DRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVF 82
++ KVI+EL+ TE+ Y++DL E + P+Q + + + E LFG++ +++ K
Sbjct: 783 EKRAKVIEELLQTERDYIRDLEMCIERIMVPMQ-QAQVPNIDFEGLFGNMQMVIKVSKQL 841
Query: 83 LETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGFCANHIKVQKVLE 141
L LE + ++G FL + D + Y +C NH + +LE
Sbjct: 842 LAALE--------------------ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLE 881
Query: 142 RAKTDKAFKAFL-----DARNPTKQHSST----LESYLIKPVQRVLKYPLLLKELVSLTD 192
+ D+ + L D ++ + T L S+LIKPVQRV++YPLLL EL++ T
Sbjct: 882 IYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTP 941
Query: 193 QESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELL 252
+ + LT A+ A++++ +INE Y D ++ + G E + E + +L
Sbjct: 942 ESHPDKVPLTNAVLAVKEINVNINE-------YKRRKDLVLKYRKGDEDSLME-KISKLN 993
Query: 253 MHSTVSWLN 261
+HS + N
Sbjct: 994 IHSIIKKSN 1002
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 84.3 bits (207), Expect = 3e-16
Identities = 116/488 (23%), Positives = 201/488 (41%), Gaps = 99/488 (20%)
Query: 26 RKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFL------TQDEMESLFGSLPEMLEFQ 79
R V+ EL+DTE++YV++L C+ E Y + N ++ + LFG++ E+ F
Sbjct: 660 RHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFH 719
Query: 80 -KVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQK 138
++FL LE N + P +G FL + F++Y +C N + +
Sbjct: 720 NRIFLRELE---------NYTDCPEL-------VGRCFLERMEDFQIYEKYCQNKPRSES 763
Query: 139 VLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEH 198
L R +D F F + + H +L+SYL+KPVQR+ KY LLLKE++ + + E
Sbjct: 764 -LWRQCSDCPF--FQECQRKL-DHKLSLDSYLLKPVQRITKYQLLLKEMLKYS-RNCEGA 818
Query: 199 YHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVS 258
L EAL ++ + +N+ + G +D + + +G+LLM + S
Sbjct: 819 EDLQEALSSILGILKAVNDSMHLIAITG--YDGNLGD------------LGKLLMQGSFS 864
Query: 259 -WLNPFLSLGKAR-----KDLELTVFVFKRAVILVYK--ENCKLKKKLPSNSRPAHNSTD 310
W + K + K ++ +F+ ++AV+ K EN + +K PS
Sbjct: 865 VWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPS---------- 914
Query: 311 LDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTN 370
+ ++ + ++A+ + + IW E ++ + E K
Sbjct: 915 ---YSYKQSLNMAAVGITENVKGDAKKFEIW---------YNAREEVYIVQAPTPEIKAA 962
Query: 371 IVKVIRSILRENFR--RHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKNSSS 428
V IR +L + R LE++ + +PL S +SR++K L+ +
Sbjct: 963 WVNEIRKVLTSQLQACREASQHRALEQS---QSLPLPAPTSTSPSRGNSRNIKKLEERKT 1019
Query: 429 NEWT-------------GETGKGTLLDS-------DEGSLSSGTQSSGCPTAE--GRQDS 466
+ + E GKG S D+G SS + AE G
Sbjct: 1020 DPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGP 1079
Query: 467 KSTSPGKY 474
K PGKY
Sbjct: 1080 KKLVPGKY 1087
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 84.3 bits (207), Expect = 3e-16
Identities = 116/488 (23%), Positives = 201/488 (41%), Gaps = 99/488 (20%)
Query: 26 RKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFL------TQDEMESLFGSLPEMLEFQ 79
R V+ EL+DTE++YV++L C+ E Y + N ++ + LFG++ E+ F
Sbjct: 607 RHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFH 666
Query: 80 -KVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQK 138
++FL LE N + P +G FL + F++Y +C N + +
Sbjct: 667 NRIFLRELE---------NYTDCPEL-------VGRCFLERMEDFQIYEKYCQNKPRSES 710
Query: 139 VLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEH 198
L R +D F F + + H +L+SYL+KPVQR+ KY LLLKE++ + + E
Sbjct: 711 -LWRQCSDCPF--FQECQRKL-DHKLSLDSYLLKPVQRITKYQLLLKEMLKYS-RNCEGA 765
Query: 199 YHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVS 258
L EAL ++ + +N+ + G +D + + +G+LLM + S
Sbjct: 766 EDLQEALSSILGILKAVNDSMHLIAITG--YDGNLGD------------LGKLLMQGSFS 811
Query: 259 -WLNPFLSLGKAR-----KDLELTVFVFKRAVILVYK--ENCKLKKKLPSNSRPAHNSTD 310
W + K + K ++ +F+ ++AV+ K EN + +K PS
Sbjct: 812 VWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPS---------- 861
Query: 311 LDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTN 370
+ ++ + ++A+ + + IW E ++ + E K
Sbjct: 862 ---YSYKQSLNMAAVGITENVKGDAKKFEIW---------YNAREEVYIVQAPTPEIKAA 909
Query: 371 IVKVIRSILRENFR--RHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKNSSS 428
V IR +L + R LE++ + +PL S +SR++K L+ +
Sbjct: 910 WVNEIRKVLTSQLQACREASQHRALEQS---QSLPLPAPTSTSPSRGNSRNIKKLEERKT 966
Query: 429 NEWT-------------GETGKGTLLDS-------DEGSLSSGTQSSGCPTAE--GRQDS 466
+ + E GKG S D+G SS + AE G
Sbjct: 967 DPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGP 1026
Query: 467 KSTSPGKY 474
K PGKY
Sbjct: 1027 KKLVPGKY 1034
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 81.3 bits (199), Expect = 3e-15
Identities = 92/351 (26%), Positives = 157/351 (44%), Gaps = 66/351 (18%)
Query: 22 ADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETF-----LTQDEMESLFGSLPEML 76
A R ++ EL+ TEK+YV+DL + YL + + + E+ +FG++ E+
Sbjct: 1290 ARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKEL-IIFGNMQEIY 1348
Query: 77 EFQK-VFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHI- 134
EF +FL+ LE ++ +L +G F+ +AD F++Y +C N
Sbjct: 1349 EFHNNIFLKELE----------------KYEQLPEDVGHCFVTWADKFQMYVTYCKNKPD 1392
Query: 135 KVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQE 194
Q +LE A + + D ++++ SYLIKPVQR+ KY LLLKEL++ ++
Sbjct: 1393 STQLILEHAGS------YFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG 1446
Query: 195 SEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMH 254
E + + L+ M V N+ + G FD+ + Q GEL++
Sbjct: 1447 KGE---IKDGLEVMLSVPKRANDAMHLSMLEG--FDENIESQ------------GELILQ 1489
Query: 255 STVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCK---------LKKKLPSNSRPA 305
+ +P + K R E +F+F+ + LV+ + K K KL ++
Sbjct: 1490 ESFQVWDPKTLIRKGR---ERHLFLFEMS--LVFSKEVKDSSGRSKYLYKSKLFTSELGV 1544
Query: 306 HNSTDLDPFKFR-WL--IPISALQVRLGNPAGTENNSIWELIHTKSEIEGR 353
+ DP KF W+ P S ++ L + EN W + H + I+ R
Sbjct: 1545 TEHVEGDPCKFALWVGRTPTSDNKIVL-KASSIENKQDW-IKHIREVIQER 1593
Score = 74.7 bits (182), Expect = 2e-13
Identities = 72/274 (26%), Positives = 121/274 (44%), Gaps = 44/274 (16%)
Query: 17 RHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMES----LFGSL 72
R S R V+QELV+TE+ YV+DL + E Y+ ++ + D+M+ +FG++
Sbjct: 1962 RKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDG--VPDDMKGKDKIVFGNI 2019
Query: 73 PEMLEFQK-VFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCA 131
++ ++ + FL LE LE P + LG F+ + +Y +C
Sbjct: 2020 HQIYDWHRDFFLGELE---------KCLEDPEK-------LGSLFVKHERRLHMYIAYCQ 2063
Query: 132 NHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLT 191
N K + ++ + F + H L LIKPVQR++KY LLLK+ + +
Sbjct: 2064 NKPKSEHIVS-----EYIDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYS 2118
Query: 192 DQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGEL 251
+ S + L A++ M V N+M + G FD + Q G+L
Sbjct: 2119 KKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQG--FDGKIVAQ------------GKL 2164
Query: 252 LMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVI 285
L+ T +L G + E +F+F++ VI
Sbjct: 2165 LLQDT--FLVTDQDAGLLPRCRERRIFLFEQIVI 2196
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 80.1 bits (196), Expect = 6e-15
Identities = 98/389 (25%), Positives = 167/389 (42%), Gaps = 94/389 (24%)
Query: 28 VIQELVDTEKSYVKDLSCLFELYLEPLQNET------FLTQDEMESLFGSLPEMLEFQK- 80
++ EL+ TEK+YV+DL E YL + + L ++ + +FG++ E+ +F
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHI--IFGNIQEIYDFHNN 1342
Query: 81 VFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKV-QKV 139
+FL+ LE ++ +L +G F+ +AD F++Y +C N Q +
Sbjct: 1343 IFLKELE----------------KYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLI 1386
Query: 140 LERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHY 199
LE A T F D ++++ SYLIKPVQR+ KY LLLKEL++ ++ E
Sbjct: 1387 LEHAGT------FFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGE-- 1438
Query: 200 HLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSW 259
L + L+ M V N+ + G FD+ + Q GEL++
Sbjct: 1439 -LKDGLEVMLSVPKKANDAMHVSMLEG--FDENLDVQ------------GELILQDAFQV 1483
Query: 260 LNPFLSLGKARKDLELTVFVFKRAVILVYKENCK---------LKKKLPSNSRPAHNSTD 310
+P + K R E +F+F+ + LV+ + K K KL ++ +
Sbjct: 1484 WDPKSLIRKGR---ERHLFLFE--ISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVE 1538
Query: 311 LDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTN 370
DP KF + G ++N ++ L S+ E+K
Sbjct: 1539 GDPCKF---------ALWSGRTPSSDNKTV-------------------LKASNIETKQE 1570
Query: 371 IVKVIRSILRE---NFRRHIKCELPLEKT 396
+K IR +++E + + +K L L KT
Sbjct: 1571 WIKNIREVIQERIIHLKGALKEPLQLPKT 1599
Score = 73.2 bits (178), Expect = 7e-13
Identities = 79/320 (24%), Positives = 134/320 (41%), Gaps = 53/320 (16%)
Query: 10 PPPRPLARHLSDADRLRK-VIQELVDTEKSYVKDLSCLFELYLEPLQN----ETFLTQDE 64
PP P + A R R V+ ELV TEK YVKDL + E +++ ++ E +D+
Sbjct: 1914 PPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDK 1973
Query: 65 MESLFGSLPEMLEFQK-VFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHF 123
+ +FG++ ++ ++ K FL LE I L F+ +
Sbjct: 1974 I--VFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQL----------------FIKHERKL 2015
Query: 124 KLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLL 183
+Y +C N + + ++ + A+ + TL +LIKP+QR+ KY LL
Sbjct: 2016 HIYVWYCQNKPRSEYIVAE------YDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLL 2069
Query: 184 LKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEV 243
LK+ + +++ E + +A++ M V N+M + G E
Sbjct: 2070 LKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQGF--------------EG 2115
Query: 244 TELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVI---LVYKENC----KLKK 296
T + G+LL T + L G + E VF+F++ VI L+ K + K+
Sbjct: 2116 TLTAQGKLLQQDTFYVIE--LDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKR 2173
Query: 297 KLPSNSRPAHNSTDLDPFKF 316
+ N + D DP KF
Sbjct: 2174 SIKMNYLVLEENVDNDPCKF 2193
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 80.1 bits (196), Expect = 6e-15
Identities = 98/389 (25%), Positives = 167/389 (42%), Gaps = 94/389 (24%)
Query: 28 VIQELVDTEKSYVKDLSCLFELYLEPLQNET------FLTQDEMESLFGSLPEMLEFQK- 80
++ EL+ TEK+YV+DL E YL + + L ++ + +FG++ E+ +F
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHI--IFGNIQEIYDFHNN 1342
Query: 81 VFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKV-QKV 139
+FL+ LE ++ +L +G F+ +AD F++Y +C N Q +
Sbjct: 1343 IFLKELE----------------KYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLI 1386
Query: 140 LERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHY 199
LE A T F D ++++ SYLIKPVQR+ KY LLLKEL++ ++ E
Sbjct: 1387 LEHAGT------FFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGE-- 1438
Query: 200 HLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSW 259
L + L+ M V N+ + G FD+ + Q GEL++
Sbjct: 1439 -LKDGLEVMLSVPKKANDAMHVSMLEG--FDENLDVQ------------GELILQDAFQV 1483
Query: 260 LNPFLSLGKARKDLELTVFVFKRAVILVYKENCK---------LKKKLPSNSRPAHNSTD 310
+P + K R E +F+F+ + LV+ + K K KL ++ +
Sbjct: 1484 WDPKSLIRKGR---ERHLFLFE--ISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVE 1538
Query: 311 LDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTN 370
DP KF + G ++N ++ L S+ E+K
Sbjct: 1539 GDPCKF---------ALWSGRTPSSDNKTV-------------------LKASNIETKQE 1570
Query: 371 IVKVIRSILRE---NFRRHIKCELPLEKT 396
+K IR +++E + + +K L L KT
Sbjct: 1571 WIKNIREVIQERIIHLKGALKEPLQLPKT 1599
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 79.3 bits (194), Expect = 1e-14
Identities = 84/378 (22%), Positives = 166/378 (43%), Gaps = 46/378 (12%)
Query: 26 RKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLET 85
++VI EL TE S+++ L L ++ + ++ E + ++E+ LF +LPE++E + E
Sbjct: 776 QEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEA 835
Query: 86 L----EDG--ISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKV 139
+ E+G I SD R+ L + F Y I ++ +
Sbjct: 836 MKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQS------------IALELI 883
Query: 140 LERAKTDKAFKAFL-DARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEH 198
+ + + F+ F+ +A + + L +I +QR+ KYPLLL+ ++ T+ + EH
Sbjct: 884 KTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEH 943
Query: 199 YHLTEALKAMEKVASHINEMQKIYED------YGTVFDQLVAEQS----GTEKEVTELSM 248
L A ++ ++NE K E+ Y D E++ E + +L+
Sbjct: 944 EKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTT 1003
Query: 249 GELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNS 308
+++ ++W + K K L+L V + + ++L+ K++ KL L +S+ A S
Sbjct: 1004 RKMIHEGPLTW-----RISK-DKTLDLHVLLLEDLLVLLQKQDEKL--LLKCHSKTAVGS 1055
Query: 309 TDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESK 368
+D + P+ L L T+ + + + +K P I++L S K
Sbjct: 1056 SD----SKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKL----GPPQIYELVALTSSDK 1107
Query: 369 TNIVKVIRSILRENFRRH 386
++++ +R N RH
Sbjct: 1108 NTWMELLEEAVR-NATRH 1124
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 79.3 bits (194), Expect = 1e-14
Identities = 84/378 (22%), Positives = 166/378 (43%), Gaps = 46/378 (12%)
Query: 26 RKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLET 85
++VI EL TE S+++ L L ++ + ++ E + ++E+ LF +LPE++E + E
Sbjct: 736 QEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEA 795
Query: 86 L----EDG--ISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKV 139
+ E+G I SD R+ L + F Y I ++ +
Sbjct: 796 MKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQS------------IALELI 843
Query: 140 LERAKTDKAFKAFL-DARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEH 198
+ + + F+ F+ +A + + L +I +QR+ KYPLLL+ ++ T+ + EH
Sbjct: 844 KTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEH 903
Query: 199 YHLTEALKAMEKVASHINEMQKIYED------YGTVFDQLVAEQS----GTEKEVTELSM 248
L A ++ ++NE K E+ Y D E++ E + +L+
Sbjct: 904 EKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTT 963
Query: 249 GELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNS 308
+++ ++W + K K L+L V + + ++L+ K++ KL L +S+ A S
Sbjct: 964 RKMIHEGPLTW-----RISK-DKTLDLHVLLLEDLLVLLQKQDEKL--LLKCHSKTAVGS 1015
Query: 309 TDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESK 368
+D + P+ L L T+ + + + +K P I++L S K
Sbjct: 1016 SD----SKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKL----GPPQIYELVALTSSDK 1067
Query: 369 TNIVKVIRSILRENFRRH 386
++++ +R N RH
Sbjct: 1068 NTWMELLEEAVR-NATRH 1084
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 79.3 bits (194), Expect = 1e-14
Identities = 72/269 (26%), Positives = 127/269 (47%), Gaps = 28/269 (10%)
Query: 29 IQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLED 88
I EL+ TE+ Y+ DL + E++ + + FLT+ EM +F + E++ L+ L
Sbjct: 1187 IHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRV 1246
Query: 89 GISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKA 148
+ + P Q +G H + Y FC+ + +L++ KTD+
Sbjct: 1247 RKKTGGE----KMPVQM------IGDILAAELSHMQAYIRFCSCQLNGAALLQQ-KTDED 1295
Query: 149 --FKAFLD--ARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEA 204
FK FL A +P + L S+L+KP+QR+ +YPLL++ ++ T + +H L A
Sbjct: 1296 TDFKEFLKKLASDP-RCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLA 1354
Query: 205 LKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFL 264
L+ E++ S +NE + E+ D+L Q+ + E +L+ +S + L P
Sbjct: 1355 LERAEELCSQVNEGVREKEN----SDRLEWIQAHVQ---CEGLAEQLIFNSLTNCLGPRK 1407
Query: 265 -----SLGKARKDLELTVFVFKRAVILVY 288
L K + + EL F+F ++L Y
Sbjct: 1408 LLHSGKLYKTKSNKELHGFLFNDFLLLTY 1436
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 79.3 bits (194), Expect = 1e-14
Identities = 72/269 (26%), Positives = 127/269 (47%), Gaps = 28/269 (10%)
Query: 29 IQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLED 88
I EL+ TE+ Y+ DL + E++ + + FLT+ EM +F + E++ L+ L
Sbjct: 1214 IHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRV 1273
Query: 89 GISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKA 148
+ + P Q +G H + Y FC+ + +L++ KTD+
Sbjct: 1274 RKKTGGE----KMPVQM------IGDILAAELSHMQAYIRFCSCQLNGAALLQQ-KTDED 1322
Query: 149 --FKAFLD--ARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEA 204
FK FL A +P + L S+L+KP+QR+ +YPLL++ ++ T + +H L A
Sbjct: 1323 TDFKEFLKKLASDP-RCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLA 1381
Query: 205 LKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFL 264
L+ E++ S +NE + E+ D+L Q+ + E +L+ +S + L P
Sbjct: 1382 LERAEELCSQVNEGVREKEN----SDRLEWIQAHVQ---CEGLAEQLIFNSLTNCLGPRK 1434
Query: 265 -----SLGKARKDLELTVFVFKRAVILVY 288
L K + + EL F+F ++L Y
Sbjct: 1435 LLHSGKLYKTKSNKELHGFLFNDFLLLTY 1463
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 79.0 bits (193), Expect = 1e-14
Identities = 81/340 (23%), Positives = 148/340 (43%), Gaps = 78/340 (22%)
Query: 29 IQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLED 88
+ E+ TE+ Y + L + + ++ PL+ FLT E +S+F ++PE+++ + ++ + D
Sbjct: 197 LAEIKQTEEKYTETLESIEKYFMAPLKR--FLTAAEFDSVFINIPELVKLHRNLMQEIHD 254
Query: 89 GISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLER-AKTDK 147
I +D N + F+ Y + +Y +C+ L+ +KT +
Sbjct: 255 SIVNKNDQNLYQV--------------FINYKERLVIYGQYCSGVESAISSLDYISKTKE 300
Query: 148 AFKAFLDARNPTKQHSS-TLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALK 206
K L+ + + TL L+ P+QRVLKY LLL+ELV T +E+ +L AL
Sbjct: 301 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEK-ANLKLALD 359
Query: 207 AMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSL 266
AM+ +A ++NE+++ E T +E+ + + S + P L
Sbjct: 360 AMKDLAQYVNEVKRDNE---------------TLREIKQFQL------SIENLNQPVLLF 398
Query: 267 GKARKDLELT-------------VFVFKRAVILVYKENCKLKKKLPSNSRPAHNSTDLDP 313
G+ + D E+ +F+F AVI+ CK K D
Sbjct: 399 GRPQGDGEIRITTLDKHTKQERHIFLFDLAVIV-----CKRKG---------------DN 438
Query: 314 FKFRWLIPISALQVRLGNPAGTENNSIWE----LIHTKSE 349
++ + +I + ++ NP + N W LIHT+ +
Sbjct: 439 YEMKEIIDLQQYKI-ANNPTTDKENKKWSYGFYLIHTQGQ 477
>gi|21735572 epithelial cell transforming sequence 2 oncogene
protein [Homo sapiens]
Length = 883
Score = 79.0 bits (193), Expect = 1e-14
Identities = 119/487 (24%), Positives = 201/487 (41%), Gaps = 53/487 (10%)
Query: 27 KVIQELVDTEKSYVKDLSCLFELYLEPLQNE-----TFLTQDEMESLFGSLPEMLEFQKV 81
+V +EL TE +YV L+ + +L+ PL+ E L +E++++FGS+P++ +
Sbjct: 424 QVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTK 483
Query: 82 FLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA-DHFKLYSGFCANHIKVQK-- 138
+ LED I + S+G FL Y+ D K Y F N ++ K
Sbjct: 484 IKDDLEDLIVNWDESK-------------SIGDIFLKYSKDLVKTYPPF-VNFFEMSKET 529
Query: 139 VLERAKTDKAFKAFLDARNPTKQHS-STLESYLIKPVQRVLKYPLLLKELVSLTDQESEE 197
+++ K F AFL + +L LI+PVQR+ LLL +L T E+ +
Sbjct: 530 IIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPD 589
Query: 198 HYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTV 257
L +A+ ++++V +HINE ++ E +FD +V E G + L H ++
Sbjct: 590 KSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFD-VVYEVDGCPANL-------LSSHRSL 641
Query: 258 SWLNPFLSLGKARKDL--ELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNST-DLDPF 314
+SLG+ D ++T+F+F + E + + K+ R H T
Sbjct: 642 VQRVETISLGEHPCDRGEQVTLFLFNDCL-----EIARKRHKVIGTFRSPHGQTRPPASL 696
Query: 315 KFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTNIVK- 373
K L+P+S ++ L + ++ + L+ + FQ+ SD K N +K
Sbjct: 697 KHIHLMPLSQIKKVLDIRETEDCHNAFALLVRPPTEQANVLLSFQM-TSDELPKENWLKM 755
Query: 374 ----VIRSILRENFRRHIKCELP--LEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKNSS 427
V +I + + I P E KD L A A ++ K + +
Sbjct: 756 LCRHVANTICKADAENLIYTADPESFEVNTKDMDSTLSR-----ASRAIKKTSKKVTRAF 810
Query: 428 SNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFADNLI 487
S T + L + GS+ + SS R S S+ G P P L
Sbjct: 811 SFSKTPKRALRRALMTSHGSVEGRSPSSNDKHVMSRLSSTSSLAG-IPSPSLVSLPSFFE 869
Query: 488 KESDILS 494
+ S LS
Sbjct: 870 RRSHTLS 876
>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 78.2 bits (191), Expect = 2e-14
Identities = 54/211 (25%), Positives = 97/211 (45%), Gaps = 16/211 (7%)
Query: 11 PPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFG 70
PP+ + V+Q +++TE Y K+L + YL PLQ L+ + L G
Sbjct: 80 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMG 139
Query: 71 SLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGF 129
+L E+ FQ++ +++LE+ + P ++ +GG FL K LY +
Sbjct: 140 NLEEICSFQQMLVQSLEE---------CTKLPEAQQR----VGGCFLNLMPQMKTLYLTY 186
Query: 130 CANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVS 189
CANH VL + + F++ + + L + L KP R+ KYP LLKEL
Sbjct: 187 CANHPSAVNVL--TEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELER 244
Query: 190 LTDQESEEHYHLTEALKAMEKVASHINEMQK 220
+ + + +++ A + +++ E++K
Sbjct: 245 HMEDYHTDRQDIQKSMAAFKNLSAQCQEVRK 275
>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
sapiens]
Length = 753
Score = 78.2 bits (191), Expect = 2e-14
Identities = 54/211 (25%), Positives = 97/211 (45%), Gaps = 16/211 (7%)
Query: 11 PPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFG 70
PP+ + V+Q +++TE Y K+L + YL PLQ L+ + L G
Sbjct: 208 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMG 267
Query: 71 SLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGF 129
+L E+ FQ++ +++LE+ + P ++ +GG FL K LY +
Sbjct: 268 NLEEICSFQQMLVQSLEE---------CTKLPEAQQR----VGGCFLNLMPQMKTLYLTY 314
Query: 130 CANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVS 189
CANH VL + + F++ + + L + L KP R+ KYP LLKEL
Sbjct: 315 CANHPSAVNVL--TEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELER 372
Query: 190 LTDQESEEHYHLTEALKAMEKVASHINEMQK 220
+ + + +++ A + +++ E++K
Sbjct: 373 HMEDYHTDRQDIQKSMAAFKNLSAQCQEVRK 403
>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
sapiens]
Length = 803
Score = 78.2 bits (191), Expect = 2e-14
Identities = 54/211 (25%), Positives = 97/211 (45%), Gaps = 16/211 (7%)
Query: 11 PPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFG 70
PP+ + V+Q +++TE Y K+L + YL PLQ L+ + L G
Sbjct: 258 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMG 317
Query: 71 SLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGF 129
+L E+ FQ++ +++LE+ + P ++ +GG FL K LY +
Sbjct: 318 NLEEICSFQQMLVQSLEE---------CTKLPEAQQR----VGGCFLNLMPQMKTLYLTY 364
Query: 130 CANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVS 189
CANH VL + + F++ + + L + L KP R+ KYP LLKEL
Sbjct: 365 CANHPSAVNVL--TEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELER 422
Query: 190 LTDQESEEHYHLTEALKAMEKVASHINEMQK 220
+ + + +++ A + +++ E++K
Sbjct: 423 HMEDYHTDRQDIQKSMAAFKNLSAQCQEVRK 453
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,616,444
Number of Sequences: 37866
Number of extensions: 1165543
Number of successful extensions: 3878
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 110
Number of HSP's successfully gapped in prelim test: 56
Number of HSP's that attempted gapping in prelim test: 3607
Number of HSP's gapped (non-prelim): 226
length of query: 626
length of database: 18,247,518
effective HSP length: 108
effective length of query: 518
effective length of database: 14,157,990
effective search space: 7333838820
effective search space used: 7333838820
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.