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Search of human proteins with 58331187
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a
[Homo sapiens]
(1701 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 3400 0.0
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ... 1247 0.0
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap... 983 0.0
gi|71274148 pleckstrin homology domain containing, family G (wit... 117 7e-26
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 108 3e-23
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 108 3e-23
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 105 3e-22
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 102 2e-21
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 99 4e-20
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 94 9e-19
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 94 9e-19
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 94 1e-18
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom... 93 3e-18
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 88 6e-17
gi|39930351 dynamin binding protein [Homo sapiens] 86 2e-16
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo... 86 2e-16
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 84 9e-16
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 84 9e-16
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 83 3e-15
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 80 2e-14
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 80 2e-14
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 79 3e-14
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 79 3e-14
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 79 3e-14
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 79 3e-14
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 79 4e-14
gi|21735572 epithelial cell transforming sequence 2 oncogene pro... 79 4e-14
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 78 6e-14
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom... 78 6e-14
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom... 78 6e-14
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
sapiens]
Length = 1701
Score = 3400 bits (8816), Expect = 0.0
Identities = 1701/1701 (100%), Positives = 1701/1701 (100%)
Query: 1 MGNSDSQYTLQGSKNHSNTITGAKQIPCSLKIRGIHAKEEKSLHGWGHGSNGAGYKSRSL 60
MGNSDSQYTLQGSKNHSNTITGAKQIPCSLKIRGIHAKEEKSLHGWGHGSNGAGYKSRSL
Sbjct: 1 MGNSDSQYTLQGSKNHSNTITGAKQIPCSLKIRGIHAKEEKSLHGWGHGSNGAGYKSRSL 60
Query: 61 ARSCLSHFKSNQPYASRLGGPTCKVSRGVAYSTHRTNAPGKDFQGISAAFSTENGFHSVG 120
ARSCLSHFKSNQPYASRLGGPTCKVSRGVAYSTHRTNAPGKDFQGISAAFSTENGFHSVG
Sbjct: 61 ARSCLSHFKSNQPYASRLGGPTCKVSRGVAYSTHRTNAPGKDFQGISAAFSTENGFHSVG 120
Query: 121 HELADNHITSRDCNGHLLNCYGRNESIASTPPGEDRKSPRVLIKTLGKLDGCLRVEFHNG 180
HELADNHITSRDCNGHLLNCYGRNESIASTPPGEDRKSPRVLIKTLGKLDGCLRVEFHNG
Sbjct: 121 HELADNHITSRDCNGHLLNCYGRNESIASTPPGEDRKSPRVLIKTLGKLDGCLRVEFHNG 180
Query: 181 GNPSKVPAEDCSEPVQLLRYSPTLASETSPVPEARRGSSADSLPSHRPSPTDSRLRSSKG 240
GNPSKVPAEDCSEPVQLLRYSPTLASETSPVPEARRGSSADSLPSHRPSPTDSRLRSSKG
Sbjct: 181 GNPSKVPAEDCSEPVQLLRYSPTLASETSPVPEARRGSSADSLPSHRPSPTDSRLRSSKG 240
Query: 241 SSLSSESSWYDSPWGNAGELSEAEGSFLAPGMPDPSLHASFPPGDAKKPFNQSSSLSSLR 300
SSLSSESSWYDSPWGNAGELSEAEGSFLAPGMPDPSLHASFPPGDAKKPFNQSSSLSSLR
Sbjct: 241 SSLSSESSWYDSPWGNAGELSEAEGSFLAPGMPDPSLHASFPPGDAKKPFNQSSSLSSLR 300
Query: 301 ELYKDANLGSLSPSGIRLSDEYMGTHASLSNRVSFASDIDVPSRVAHGDPIQYSSFTLPC 360
ELYKDANLGSLSPSGIRLSDEYMGTHASLSNRVSFASDIDVPSRVAHGDPIQYSSFTLPC
Sbjct: 301 ELYKDANLGSLSPSGIRLSDEYMGTHASLSNRVSFASDIDVPSRVAHGDPIQYSSFTLPC 360
Query: 361 RKPKAFVEDTAKKDSLKARMRRISDWTGSLSRKKRKLQEPRSKEGSDYFDSRSDGLNTDV 420
RKPKAFVEDTAKKDSLKARMRRISDWTGSLSRKKRKLQEPRSKEGSDYFDSRSDGLNTDV
Sbjct: 361 RKPKAFVEDTAKKDSLKARMRRISDWTGSLSRKKRKLQEPRSKEGSDYFDSRSDGLNTDV 420
Query: 421 QGSSQASAFLWSGGSTQILSQRSESTHAIGSDPLRQNIYENFMRELEMSRTNTENIETST 480
QGSSQASAFLWSGGSTQILSQRSESTHAIGSDPLRQNIYENFMRELEMSRTNTENIETST
Sbjct: 421 QGSSQASAFLWSGGSTQILSQRSESTHAIGSDPLRQNIYENFMRELEMSRTNTENIETST 480
Query: 481 ETAESSSESLSSLEQLDLLFEKEQGVVRKAGWLFFKPLVTVQKERKLELVARRKWKQYWV 540
ETAESSSESLSSLEQLDLLFEKEQGVVRKAGWLFFKPLVTVQKERKLELVARRKWKQYWV
Sbjct: 481 ETAESSSESLSSLEQLDLLFEKEQGVVRKAGWLFFKPLVTVQKERKLELVARRKWKQYWV 540
Query: 541 TLKGCTLLFYETYGKNSMDQSSAPRCALFAEDSIVQSVPEHPKKENVFCLSNSFGDVYLF 600
TLKGCTLLFYETYGKNSMDQSSAPRCALFAEDSIVQSVPEHPKKENVFCLSNSFGDVYLF
Sbjct: 541 TLKGCTLLFYETYGKNSMDQSSAPRCALFAEDSIVQSVPEHPKKENVFCLSNSFGDVYLF 600
Query: 601 QATSQTDLENWVTAVHSACASLFAKKHGKEDTLRLLKNQTKNLLQKIDMDSKMKKMAELQ 660
QATSQTDLENWVTAVHSACASLFAKKHGKEDTLRLLKNQTKNLLQKIDMDSKMKKMAELQ
Sbjct: 601 QATSQTDLENWVTAVHSACASLFAKKHGKEDTLRLLKNQTKNLLQKIDMDSKMKKMAELQ 660
Query: 661 LSVVSDPKNRKAIENQIQQWEQNLEKFHMDLFRMRCYLASLQGGELPNPKSLLAAASRPS 720
LSVVSDPKNRKAIENQIQQWEQNLEKFHMDLFRMRCYLASLQGGELPNPKSLLAAASRPS
Sbjct: 661 LSVVSDPKNRKAIENQIQQWEQNLEKFHMDLFRMRCYLASLQGGELPNPKSLLAAASRPS 720
Query: 721 KLALGRLGILSVSSFHALVCSRDDSALRKRTLSLTQRGRNKKGIFSSLKGLDTLARKGKE 780
KLALGRLGILSVSSFHALVCSRDDSALRKRTLSLTQRGRNKKGIFSSLKGLDTLARKGKE
Sbjct: 721 KLALGRLGILSVSSFHALVCSRDDSALRKRTLSLTQRGRNKKGIFSSLKGLDTLARKGKE 780
Query: 781 KRPSITQVDELLHIYGSTVDGVPRDNAWEIQTYVHFQDNHGVTVGIKPEHRVEDILTLAC 840
KRPSITQVDELLHIYGSTVDGVPRDNAWEIQTYVHFQDNHGVTVGIKPEHRVEDILTLAC
Sbjct: 781 KRPSITQVDELLHIYGSTVDGVPRDNAWEIQTYVHFQDNHGVTVGIKPEHRVEDILTLAC 840
Query: 841 KMRQLEPSHYGLQLRKLVDDNVEYCIPAPYEYMQQQVYDEIEVFPLNVYDVQLTKTGSVC 900
KMRQLEPSHYGLQLRKLVDDNVEYCIPAPYEYMQQQVYDEIEVFPLNVYDVQLTKTGSVC
Sbjct: 841 KMRQLEPSHYGLQLRKLVDDNVEYCIPAPYEYMQQQVYDEIEVFPLNVYDVQLTKTGSVC 900
Query: 901 DFGFAVTAQVDERQHLSRIFISDVLPDGLAYGEGLRKGNEIMTLNGEAVSDLDLKQMEAL 960
DFGFAVTAQVDERQHLSRIFISDVLPDGLAYGEGLRKGNEIMTLNGEAVSDLDLKQMEAL
Sbjct: 901 DFGFAVTAQVDERQHLSRIFISDVLPDGLAYGEGLRKGNEIMTLNGEAVSDLDLKQMEAL 960
Query: 961 FSEKSVGLTLIARPPDTKATLCTSWSDSDLFSRDQKSLLPPPNQSQLLEEFLDNFKKNTA 1020
FSEKSVGLTLIARPPDTKATLCTSWSDSDLFSRDQKSLLPPPNQSQLLEEFLDNFKKNTA
Sbjct: 961 FSEKSVGLTLIARPPDTKATLCTSWSDSDLFSRDQKSLLPPPNQSQLLEEFLDNFKKNTA 1020
Query: 1021 NDFSNVPDITTGLKRSQTDGTLDQVSHREKMEQTFRSAEQITALCRSFNDSQANGMEGPR 1080
NDFSNVPDITTGLKRSQTDGTLDQVSHREKMEQTFRSAEQITALCRSFNDSQANGMEGPR
Sbjct: 1021 NDFSNVPDITTGLKRSQTDGTLDQVSHREKMEQTFRSAEQITALCRSFNDSQANGMEGPR 1080
Query: 1081 ENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEM 1140
ENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEM
Sbjct: 1081 ENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEM 1140
Query: 1141 ESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKL 1200
ESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKL
Sbjct: 1141 ESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKL 1200
Query: 1201 YSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLK 1260
YSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLK
Sbjct: 1201 YSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLK 1260
Query: 1261 ELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTE 1320
ELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTE
Sbjct: 1261 ELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTE 1320
Query: 1321 LSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPA 1380
LSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPA
Sbjct: 1321 LSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPA 1380
Query: 1381 HNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDS 1440
HNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDS
Sbjct: 1381 HNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDS 1440
Query: 1441 ESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKN 1500
ESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKN
Sbjct: 1441 ESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKN 1500
Query: 1501 SSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFADN 1560
SSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFADN
Sbjct: 1501 SSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFADN 1560
Query: 1561 LIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPESGEGQK 1620
LIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPESGEGQK
Sbjct: 1561 LIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPESGEGQK 1620
Query: 1621 GGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLEREFSV 1680
GGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLEREFSV
Sbjct: 1621 GGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLEREFSV 1680
Query: 1681 QSLTSVVSEECFYETESHGKS 1701
QSLTSVVSEECFYETESHGKS
Sbjct: 1681 QSLTSVVSEECFYETESHGKS 1701
>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b [Homo
sapiens]
Length = 626
Score = 1247 bits (3227), Expect = 0.0
Identities = 626/626 (100%), Positives = 626/626 (100%)
Query: 1076 MEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFL 1135
MEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFL
Sbjct: 1 MEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFL 60
Query: 1136 TQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA 1195
TQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA
Sbjct: 61 TQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA 120
Query: 1196 DHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKY 1255
DHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKY
Sbjct: 121 DHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKY 180
Query: 1256 PLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTE 1315
PLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTE
Sbjct: 181 PLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTE 240
Query: 1316 KEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPS 1375
KEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPS
Sbjct: 241 KEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPS 300
Query: 1376 NSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQL 1435
NSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQL
Sbjct: 301 NSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQL 360
Query: 1436 CCSDSESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSL 1495
CCSDSESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSL
Sbjct: 361 CCSDSESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSL 420
Query: 1496 KVLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLA 1555
KVLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLA
Sbjct: 421 KVLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLA 480
Query: 1556 DFADNLIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPES 1615
DFADNLIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPES
Sbjct: 481 DFADNLIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPES 540
Query: 1616 GEGQKGGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLE 1675
GEGQKGGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLE
Sbjct: 541 GEGQKGGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLE 600
Query: 1676 REFSVQSLTSVVSEECFYETESHGKS 1701
REFSVQSLTSVVSEECFYETESHGKS
Sbjct: 601 REFSVQSLTSVVSEECFYETESHGKS 626
>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
Length = 1591
Score = 983 bits (2542), Expect = 0.0
Identities = 594/1351 (43%), Positives = 812/1351 (60%), Gaps = 93/1351 (6%)
Query: 297 SSLRELYKDANLGSLSPSGIRLSDEYMGTHASLSNRVSFASDIDVPSRVAHGDPIQYSSF 356
+SL +LY N G + G ++ G +L + + ++ +P A P +
Sbjct: 230 NSLGDLYAQKNSGVTANGGP--GSKFAGYCRNLVSDIPNLANHKMPPAAAEETPPYSNYN 287
Query: 357 TLPCRKPKAFVEDTAKKDSLKARMRRISDWTGSLSRKKRKLQEPRSKEGSDYFDSRSDGL 416
TLPCRK E +IS R+ + Q+ + EGS++ DS +G
Sbjct: 288 TLPCRKSHCLSEGATNP--------QISHSNSMQGRRAKTTQDVNAGEGSEFADSGIEGA 339
Query: 417 NTDVQGSSQASAFLWSGGS--TQILSQRSESTHAIGSDPLRQNIYENFMRELEMSRTNTE 474
TD S+ S S S T S+S + D RQ +YENF RELEMS TN+E
Sbjct: 340 TTDTDLLSRRSNATNSSYSPTTGRAFVGSDSGSSSTGDAARQGVYENFRRELEMSTTNSE 399
Query: 475 NIET--STETAESSSESLSSLEQLDLLFEKEQGVVRKAGWLFFKPLVTVQKERKLELVAR 532
++E S + E SS +LSS Q D+L QG VRKAG L K + +K +K+E R
Sbjct: 400 SLEEAGSAHSDEQSSGTLSSPGQSDILLTAAQGTVRKAGALAVKNFLVHKKNKKVESATR 459
Query: 533 RKWKQYWVTLKGCTLLFYETYGKNSMDQSSAPRCALFAEDSIVQSVPEHPKKENVFCLSN 592
RKWK YWV+LKGCTL FYE+ G++ +D +S P+ A++ E+SIVQ+VPEHPKK+ VFCLSN
Sbjct: 460 RKWKHYWVSLKGCTLFFYESDGRSGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFCLSN 519
Query: 593 SFGDVYLFQATSQTDLENWVTAVHSACASLFAKKHGKEDTLRLLKNQTKNLLQKIDMDSK 652
S GD +LFQ TSQT+LENW+TA+HSACA+ A+ H KEDTLRLLK++ K L QKIDMD K
Sbjct: 520 SLGDAFLFQTTSQTELENWITAIHSACATAVARHHHKEDTLRLLKSEIKKLEQKIDMDEK 579
Query: 653 MKKMAELQLSVVSDPKNRKAIENQIQQWEQNLEKFHMDLFRMRCYLASLQGGELPNPKSL 712
MKKM E+QLS V+D K +K I +QI WEQNLE+F MDLFR RCYLASLQGGELPNPK L
Sbjct: 580 MKKMGEMQLSSVTDSKKKKTILDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPKRL 639
Query: 713 LAAASRPSKLALGRLGILSVSSFHALVCSRD-DSALRKRTLSLTQRGRNKKGIFSSLKGL 771
LA ASRP+K+A+GRLGI SVSSFHALV +R ++ +R+RT ++++ ++ FSSL GL
Sbjct: 640 LAFASRPTKVAMGRLGIFSVSSFHALVAARTGETGVRRRTQAMSRSASKRRSRFSSLWGL 699
Query: 772 DTLARKGKEKRPSITQV---------DELLHIYGSTVDGVPRDNAW----------EIQT 812
DT ++K K+ RPSI QV L I+ V R+ +
Sbjct: 700 DTTSKK-KQGRPSINQVFGEGTEAVKKSLEGIFDDIVPDGKREKEVVLPNVHQHNPDCDI 758
Query: 813 YVH---------FQDNHGVTVGIKPEHRVEDILTLACKMRQLEPSHYGLQLRKLVDDNVE 863
+VH +N ++P D L L CK QL+ S + L+L+ L+++ ++
Sbjct: 759 WVHEYFTPSWFCLPNNQPALTVVRPGDTARDTLELICKTHQLDHSAHYLRLKFLIENKMQ 818
Query: 864 YCIPAPYEYMQQQVYDEIEVFPLNVYDVQLTKTGSVCD-FGFAVTAQVDERQHLSRIFIS 922
+P P E + + +Y EIE+ P + + K+ + D +GF++++ E + R++++
Sbjct: 819 LYVPQPEEDIYELLYKEIEICPKVTQSIHIEKSDTAADTYGFSLSSV--EEDGIRRLYVN 876
Query: 923 DVLPDGLAYGEGLRKGNEIMTLNGEAVSDLDLKQMEALFSEKSVGLTLIARPPDTKATLC 982
V GLA +GL+ G+EI+ +N A L+ ++ S+ S+GL + P
Sbjct: 877 SVKETGLASKKGLKAGDEILEINNRAADALNSSMLKDFLSQPSLGLLVRTYPE------- 929
Query: 983 TSWSDSDLFSRDQKSLLPPPNQ----SQLLEEFLDNFKKNTANDFSNVPDITTGLKRSQT 1038
+ L PP++ + L E L N + + + +T
Sbjct: 930 --------LEEGVELLESPPHRVDGPADLGESPLAFLTSNPGHSLCSEQGSSAETAPEET 981
Query: 1039 DGTLDQVSHREKMEQTFRSAEQITALCRSFNDSQANGMEGPRENQDPPPRPLARHLSDAD 1098
+G + ++ + + +S EQ+ A CRS ++ + ++ P R LSDAD
Sbjct: 982 EGP--DLESSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPSPQDSTGPQLATMRQLSDAD 1039
Query: 1099 RLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFL 1158
+LRKVI EL++TE++YVKDL+CL E YL+PLQ ETFLTQDE++ LFG+L EM+EFQ FL
Sbjct: 1040 KLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFL 1099
Query: 1159 ETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERA 1218
+TLEDG+ D LE QF+K+LFSLGGSFLYYAD FKLYS FCA+H KV KVL +A
Sbjct: 1100 KTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKA 1159
Query: 1219 KTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTE 1278
KTD AFKAFLDA+NP +QHSSTLESYLIKP+QR+LKYPLLL+EL +LTD ESEEHYHL
Sbjct: 1160 KTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDV 1219
Query: 1279 ALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPF 1338
A+K M KVASHINEMQKI+E++G VFDQL+AEQ+G +KEV +LSMG+LL+H+TV WLNP
Sbjct: 1220 AIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVADLSMGDLLLHTTVIWLNPP 1279
Query: 1339 LSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNSTDLDPFKFRWLIPIS 1398
SLGK +K+ EL FVFK AV+LVYK+ K KKKL + R + D DPF+FR +IP
Sbjct: 1280 ASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRLSIYE-DWDPFRFRHMIPTE 1338
Query: 1399 ALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTNIVKVIRSILRENF 1458
ALQVR A E N++ E++H KSE EGRPE +F LCCS ES+ + +K + SILR+
Sbjct: 1339 ALQVRALASADAEANAVCEIVHVKSESEGRPERVFHLCCSSPESRKDFLKAVHSILRDKH 1398
Query: 1459 RRH-IKCE-LPLEKTC----KDRLVPLKNRVPVSAKLAS--SRSL-KVLKNSSSNEWTGE 1509
RR +K E LP + RL LK P ++ S S+SL + + + N +T
Sbjct: 1399 RRQLLKTESLPSSQQYVPFGGKRLCALKGARPAMSRAVSAPSKSLGRRRRRLARNRFT-- 1456
Query: 1510 TGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFAD-NLIKESDIL 1568
+DSD S SS + S P G T LA + + + IKE+DIL
Sbjct: 1457 ------IDSDAVSASSPEKESQQPPGGG-----DTDRWVEEQFDLAQYEEQDDIKETDIL 1505
Query: 1569 SDEDDDHRQTVKQGSPTKDIEIQFQRLRISE 1599
SD DD+ ++VK S +D++ + Q IS+
Sbjct: 1506 SD-DDEFCESVKGASVDRDLQERLQATSISQ 1535
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 117 bits (294), Expect = 7e-26
Identities = 89/313 (28%), Positives = 157/313 (50%), Gaps = 43/313 (13%)
Query: 1070 DSQANGMEGPRENQDPPPRPLARHLSD------ADR--------LRKVIQELVDTEKSYV 1115
D+ A G + E + PPR R S+ AD + +V+QE+++TE++YV
Sbjct: 70 DNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYV 129
Query: 1116 KDLSCLFELYLEPLQNETFLT--QDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNT 1173
+DL + E YL+ ++++T L +E +LFG++ ++ F L+ LE N
Sbjct: 130 QDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLE---------NC 180
Query: 1174 LETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNP 1233
P ++ F+ ++ F +Y+ +C N+ + VL +K F R
Sbjct: 181 ENDP-------VAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQE 233
Query: 1234 TKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEM 1293
T +HS L SYL+KPVQR+LKY LLL E+ + D+++E + + +A+ M++VA HIN+M
Sbjct: 234 TLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDM 293
Query: 1294 QKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVF 1353
++ +E V Q + K S GEL++ T + +A+ E T+F
Sbjct: 294 KRKHEH--AVRLQEIQSLLTNWKGPDLTSYGELVLEGT-------FRIQRAKN--ERTLF 342
Query: 1354 VFKRAVILVYKEN 1366
+F + +++ K +
Sbjct: 343 LFDKLLLITKKRD 355
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 108 bits (271), Expect = 3e-23
Identities = 100/380 (26%), Positives = 176/380 (46%), Gaps = 40/380 (10%)
Query: 1091 ARHLSDADRLRK-VIQELVDTEKSYVKDLSCLFELYLEPLQN------ETFLTQDEMESL 1143
A+ L RLR V+ EL TE+ YV L L +L + + +T++ ++ L
Sbjct: 14 AKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKML 73
Query: 1144 FGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSG 1203
F ++ ++L K FL+ +E+ + + +G FL++ D F++Y
Sbjct: 74 FSNIEDILAVHKEFLKVVEECLHPEPNAQQ------------EVGTCFLHFKDKFRIYDE 121
Query: 1204 FCANHIKVQKVLERAKTDKAFKAFL---DARNPTKQHSSTLESYLIKPVQRVLKYPLLLK 1260
+C+NH K QK+L + + FL K LE YL+ P+QR+ KYPL+LK
Sbjct: 122 YCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILK 181
Query: 1261 ELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTE 1320
EL+ T ++ ++ + EAL+AM+ V S+INE ++ E V ++ + G E
Sbjct: 182 ELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKL-EVLEEWQSHIEGWEGSNIT 240
Query: 1321 LSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPA 1380
+ E+LM + +S G + E F+F +LVY CK K + NS+
Sbjct: 241 DTCTEMLMCGVLL----KISSGNIQ---ERVFFLFDN--LLVY---CKRKHRRLKNSKA- 287
Query: 1381 HNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDS 1440
STD + FR I ++V + + +S ++ +I + + +C + +
Sbjct: 288 --STDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKT 345
Query: 1441 ESKTNIVKVIRSILRENFRR 1460
+ + + +IL+E RR
Sbjct: 346 PEEKH--EWFEAILKERERR 363
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 108 bits (271), Expect = 3e-23
Identities = 100/380 (26%), Positives = 176/380 (46%), Gaps = 40/380 (10%)
Query: 1091 ARHLSDADRLRK-VIQELVDTEKSYVKDLSCLFELYLEPLQN------ETFLTQDEMESL 1143
A+ L RLR V+ EL TE+ YV L L +L + + +T++ ++ L
Sbjct: 14 AKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKML 73
Query: 1144 FGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSG 1203
F ++ ++L K FL+ +E+ + + +G FL++ D F++Y
Sbjct: 74 FSNIEDILAVHKEFLKVVEECLHPEPNAQQ------------EVGTCFLHFKDKFRIYDE 121
Query: 1204 FCANHIKVQKVLERAKTDKAFKAFL---DARNPTKQHSSTLESYLIKPVQRVLKYPLLLK 1260
+C+NH K QK+L + + FL K LE YL+ P+QR+ KYPL+LK
Sbjct: 122 YCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILK 181
Query: 1261 ELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTE 1320
EL+ T ++ ++ + EAL+AM+ V S+INE ++ E V ++ + G E
Sbjct: 182 ELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKL-EVLEEWQSHIEGWEGSNIT 240
Query: 1321 LSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPA 1380
+ E+LM + +S G + E F+F +LVY CK K + NS+
Sbjct: 241 DTCTEMLMCGVLL----KISSGNIQ---ERVFFLFDN--LLVY---CKRKHRRLKNSKA- 287
Query: 1381 HNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDS 1440
STD + FR I ++V + + +S ++ +I + + +C + +
Sbjct: 288 --STDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKT 345
Query: 1441 ESKTNIVKVIRSILRENFRR 1460
+ + + +IL+E RR
Sbjct: 346 PEEKH--EWFEAILKERERR 363
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 105 bits (263), Expect = 3e-22
Identities = 108/403 (26%), Positives = 178/403 (44%), Gaps = 41/403 (10%)
Query: 1070 DSQANGMEGPRENQDPPPRPLARHLSDADRLRK-VIQELVDTEKSYVKDLSCLFELYLEP 1128
D +A G P + P P AR RLR V+ E++ TE+ YV L L +L
Sbjct: 21 DPRAPGAAAP--SSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHR 78
Query: 1129 LQN------ETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRK 1182
++ E LT++ ++ LF ++ ++LE K FL LE + E SQ
Sbjct: 79 IRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHP-------EPQSQHE- 130
Query: 1183 LLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDA---RNPTKQHSS 1239
LG FL + D F +Y +C+NH K ++L +AFL + K
Sbjct: 131 ----LGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDI 186
Query: 1240 TLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYED 1299
LE YL+ P+QR+ KYPLLLKEL T + +H + AL+AM+ V S+INE ++ E
Sbjct: 187 PLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEK 246
Query: 1300 YGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAV 1359
+QL + G E +LL+ T+ ++ A E F+F
Sbjct: 247 L-EALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKIS-------AGNIQERAFFLFDN-- 296
Query: 1360 ILVYKENCKLKKKLPSNSRPAHNSTDLDP--FKFRWLIPISALQVRLGNPAGTENNSIWE 1417
+LVY CK K ++ + + + ++ + FR I ++V + +S
Sbjct: 297 LLVY---CKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGY 353
Query: 1418 LIHTKSEIEGRPETIFQLCCSDSESKTNIVKVIRSILRENFRR 1460
+ +I + + +C + + + K + +I+RE +R
Sbjct: 354 TVTNGWKIHNTAKNKWFVCMAKTAEEKQ--KWLDAIIREREQR 394
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 102 bits (255), Expect = 2e-21
Identities = 78/299 (26%), Positives = 144/299 (48%), Gaps = 29/299 (9%)
Query: 1077 EGPRENQDPPPRP------LARHLSDADRLR-KVIQELVDTEKSYVKDLSCLFELYLEPL 1129
EGP + Q+ P L R L + D++R VI E++ TE+ Y+K L + E YL+
Sbjct: 74 EGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQC 133
Query: 1130 QNETFLTQDE-MESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLG 1188
+ + DE ++ +FG++ ++ FQ F+ LE +N + P L +G
Sbjct: 134 RKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLE------KQYNN-DDPH-----LSEIG 181
Query: 1189 GSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSS-TLESYLIK 1247
FL + D F +YS +C NH+ L + D ++ F +A +Q ++ +L+
Sbjct: 182 PCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLT 241
Query: 1248 PVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQL 1307
PVQ++ KYPL L EL+ T Q+ ++ ++ AL M V INE ++ E+ +
Sbjct: 242 PVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQ 301
Query: 1308 VAEQSGTEKEVTELSMGELLMHSTVSWL-NPFLSLGKARKDLELTVFVFKRAVILVYKE 1365
+ +++ + S EL+ ++W+ P+ ++ + F+F ++L K+
Sbjct: 302 ASVLDWEGEDILDRS-SELIYTGEMAWIYQPY------GRNQQRVFFLFDHQMVLCKKD 353
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 99.0 bits (245), Expect = 4e-20
Identities = 79/296 (26%), Positives = 137/296 (46%), Gaps = 23/296 (7%)
Query: 1074 NGMEGPRENQDPPP-RPLARHLSDADRLR-KVIQELVDTEKSYVKDLSCLFELYLEPLQN 1131
N P E QD + RH + ++R VI+E++DTE+ Y+K L + E Y+ +
Sbjct: 213 NSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRK 272
Query: 1132 ET-FLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGS 1190
T T ++ ++FG++ ++ +FQ+ FL+ LE +N E L +G
Sbjct: 273 HTGMFTVAQLATIFGNIEDIYKFQRKFLKDLE------KQYNKEEPH------LSEIGSC 320
Query: 1191 FLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSS-TLESYLIKPV 1249
FL + F +YS +C NH L ++ F +A +Q ++ +L+ PV
Sbjct: 321 FLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPV 380
Query: 1250 QRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVA 1309
Q++ KYPL L EL+ T QE ++ ++ A +AM+ VA INE ++ E + V+
Sbjct: 381 QKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVS 440
Query: 1310 EQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKE 1365
++ L L+HS + K K + T F+F ++ K+
Sbjct: 441 IVGWEGLDI--LDRSSELIHS-----GELTKITKQGKSQQRTFFLFDHQLVSCKKD 489
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [Homo
sapiens]
Length = 690
Score = 94.4 bits (233), Expect = 9e-19
Identities = 73/252 (28%), Positives = 119/252 (47%), Gaps = 32/252 (12%)
Query: 1080 RENQDPPP---RPLARHL----------SDADRLR-KVIQELVDTEKSYVKDLSCLFELY 1125
R NQD P PLA + S D++R VI E++ TE+ Y+K L + E Y
Sbjct: 251 RVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGY 310
Query: 1126 LEPLQNET-FLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLL 1184
+ + +++++ ++FG++ ++ QK F++ LE + R L
Sbjct: 311 VRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRE------------RPHL 358
Query: 1185 FSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDA-RNPTKQHSSTLES 1243
LG FL + F++YS +C NH L R + F +A R K +L+
Sbjct: 359 SELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDG 418
Query: 1244 YLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTV 1303
+L+ PVQ++ KYPL L EL+ T + + + AL AM+ VA INE ++ E+
Sbjct: 419 FLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLEN---- 474
Query: 1304 FDQLVAEQSGTE 1315
D++ QS E
Sbjct: 475 IDKIAQWQSSIE 486
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [Homo
sapiens]
Length = 670
Score = 94.4 bits (233), Expect = 9e-19
Identities = 73/252 (28%), Positives = 119/252 (47%), Gaps = 32/252 (12%)
Query: 1080 RENQDPPP---RPLARHL----------SDADRLR-KVIQELVDTEKSYVKDLSCLFELY 1125
R NQD P PLA + S D++R VI E++ TE+ Y+K L + E Y
Sbjct: 251 RVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGY 310
Query: 1126 LEPLQNET-FLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLL 1184
+ + +++++ ++FG++ ++ QK F++ LE + R L
Sbjct: 311 VRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRE------------RPHL 358
Query: 1185 FSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDA-RNPTKQHSSTLES 1243
LG FL + F++YS +C NH L R + F +A R K +L+
Sbjct: 359 SELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDG 418
Query: 1244 YLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTV 1303
+L+ PVQ++ KYPL L EL+ T + + + AL AM+ VA INE ++ E+
Sbjct: 419 FLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLEN---- 474
Query: 1304 FDQLVAEQSGTE 1315
D++ QS E
Sbjct: 475 IDKIAQWQSSIE 486
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 93.6 bits (231), Expect = 1e-18
Identities = 67/225 (29%), Positives = 111/225 (49%), Gaps = 29/225 (12%)
Query: 1086 PPRPLARHLSDA--------DRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFL-- 1135
P P+ HLS RL +V +E+V+TE++YV+DL + E YL PL + L
Sbjct: 81 PGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGL 140
Query: 1136 TQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA 1195
+ +++ +LF ++ ++ EF LE LE+ SA + F+ +
Sbjct: 141 SVEQVGTLFANIEDIYEFSSELLEDLENSSSAGG-----------------IAECFVQRS 183
Query: 1196 DHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKY 1255
+ F +Y+ +C N+ +L +L R +HS L+S+L+KPVQR+LKY
Sbjct: 184 EDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRILKY 243
Query: 1256 PLLLKELVS--LTDQESEEHYHLTEALKAMEKVASHINEMQKIYE 1298
LLL+EL + + EA+ +M VA +IN+M++ E
Sbjct: 244 HLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQE 288
>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
sapiens]
Length = 2063
Score = 92.8 bits (229), Expect = 3e-18
Identities = 85/364 (23%), Positives = 153/364 (42%), Gaps = 29/364 (7%)
Query: 1071 SQANGMEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPL- 1129
++A E R +P P D + V L+DTE+SYV+ L L + Y++PL
Sbjct: 1038 AEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLK 1097
Query: 1130 --QNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGIS---ASSDFNTLETPSQFRKLL 1184
+N ++ +F +PE+LE + FLE + + A L S + +L
Sbjct: 1098 QPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVL 1157
Query: 1185 FSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDK-AFKAFLDARNPTKQHSSTLES 1243
++ YS + N + + + AK + AF FL+ + L
Sbjct: 1158 VNI-------------YSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSD 1204
Query: 1244 YLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYED---Y 1300
+IKPVQR+ +Y LL+K+L+ T ++ +H L EA + +++VA IN+ + E+ +
Sbjct: 1205 LMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERH 1264
Query: 1301 GTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVI 1360
V ++ A G E + + L V + ++G +KD L +F
Sbjct: 1265 ARVLQEIEAHIEGMED--LQAPLRRFLRQEMVIEVK---AIG-GKKDRSLFLFTDLIVCT 1318
Query: 1361 LVYKENCKLKKKLPSNSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIH 1420
+ +++ L++ S A +K W +P+ + G T +I + I
Sbjct: 1319 TLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAIS 1378
Query: 1421 TKSE 1424
E
Sbjct: 1379 RLDE 1382
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 88.2 bits (217), Expect = 6e-17
Identities = 77/278 (27%), Positives = 138/278 (49%), Gaps = 29/278 (10%)
Query: 1094 LSDADRLRK-VIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLE 1152
L+ +R R+ I EL+ TE++YV DL + E++ +PL LT+ E+ +F + E++
Sbjct: 1231 LTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIM 1290
Query: 1153 FQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQ 1212
L+ L S + ++ +G H + Y FC+ +
Sbjct: 1291 CNIKLLKALRVRKKMSGEKMPVKM----------IGDILSAQLPHMQPYIRFCSRQLNGA 1340
Query: 1213 KVLERAKTDKA--FKAFLD--ARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQ 1268
++++ KTD+A FK F+ A +P + L S+++KP+QRV +YPL++K ++ T +
Sbjct: 1341 ALIQQ-KTDEAPDFKEFVKRLAMDP-RCKGMPLSSFILKPMQRVTRYPLIIKNILENTPE 1398
Query: 1269 ESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLM 1328
+H HL AL+ E++ S +NE + E+ D+L Q+ + E +L+
Sbjct: 1399 NHPDHSHLKHALEKAEELCSQVNEGVREKEN----SDRLEWIQAHVQCEGLS---EQLVF 1451
Query: 1329 HSTVSWLNP--FLSLG---KARKDLELTVFVFKRAVIL 1361
+S + L P FL G KA+ + EL F+F ++L
Sbjct: 1452 NSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLL 1489
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 86.3 bits (212), Expect = 2e-16
Identities = 79/301 (26%), Positives = 138/301 (45%), Gaps = 48/301 (15%)
Query: 1046 SHREKMEQTFRSAEQITALCRSFNDSQANGMEGPRENQDPPPRPLARHLSDADRLRKVIQ 1105
S+ E + + ++T L S S G ++P R L ++ KVI+
Sbjct: 740 SNIESLNMELQQLREMTLL--SSQSSSLVAPSGSVSAENPEQRML-------EKRAKVIE 790
Query: 1106 ELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGI 1165
EL+ TE+ Y++DL E + P+Q + + + E LFG++ +++ K L LE
Sbjct: 791 ELLQTERDYIRDLEMCIERIMVPMQ-QAQVPNIDFEGLFGNMQMVIKVSKQLLAALE--- 846
Query: 1166 SASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGFCANHIKVQKVLERAKTDKAF 1224
+ ++G FL + D + Y +C NH + +LE + D+
Sbjct: 847 -----------------ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKI 889
Query: 1225 KAFL-----DARNPTKQHSST----LESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYH 1275
+ L D ++ + T L S+LIKPVQRV++YPLLL EL++ T + +
Sbjct: 890 QKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVP 949
Query: 1276 LTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWL 1335
LT A+ A++++ +INE Y D ++ + G E + E + +L +HS +
Sbjct: 950 LTNAVLAVKEINVNINE-------YKRRKDLVLKYRKGDEDSLME-KISKLNIHSIIKKS 1001
Query: 1336 N 1336
N
Sbjct: 1002 N 1002
>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
sapiens]
Length = 776
Score = 86.3 bits (212), Expect = 2e-16
Identities = 56/194 (28%), Positives = 93/194 (47%), Gaps = 16/194 (8%)
Query: 1103 VIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLE 1162
V+Q ++DTEK Y K+L L YL PLQ+ L+ E+ SL G+ E+ FQ+ + LE
Sbjct: 245 VLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALE 304
Query: 1163 DGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGFCANHIKVQKVLERAKTD 1221
+ S+F + +GG L HFK +Y +CANH VL + +
Sbjct: 305 E-------------CSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDE 351
Query: 1222 KAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALK 1281
+ F++ + + L + L KP R+ KY LL+EL + +H + +A+
Sbjct: 352 --LEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIV 409
Query: 1282 AMEKVASHINEMQK 1295
A + + +++K
Sbjct: 410 AFKTLMGQCQDLRK 423
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 84.3 bits (207), Expect = 9e-16
Identities = 116/488 (23%), Positives = 201/488 (41%), Gaps = 99/488 (20%)
Query: 1101 RKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFL------TQDEMESLFGSLPEMLEFQ 1154
R V+ EL+DTE++YV++L C+ E Y + N ++ + LFG++ E+ F
Sbjct: 660 RHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFH 719
Query: 1155 -KVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQK 1213
++FL LE N + P +G FL + F++Y +C N + +
Sbjct: 720 NRIFLRELE---------NYTDCPEL-------VGRCFLERMEDFQIYEKYCQNKPRSES 763
Query: 1214 VLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEH 1273
L R +D F F + + H +L+SYL+KPVQR+ KY LLLKE++ + + E
Sbjct: 764 -LWRQCSDCPF--FQECQRKL-DHKLSLDSYLLKPVQRITKYQLLLKEMLKYS-RNCEGA 818
Query: 1274 YHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVS 1333
L EAL ++ + +N+ + G +D + + +G+LLM + S
Sbjct: 819 EDLQEALSSILGILKAVNDSMHLIAITG--YDGNLGD------------LGKLLMQGSFS 864
Query: 1334 -WLNPFLSLGKAR-----KDLELTVFVFKRAVILVYK--ENCKLKKKLPSNSRPAHNSTD 1385
W + K + K ++ +F+ ++AV+ K EN + +K PS
Sbjct: 865 VWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPS---------- 914
Query: 1386 LDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTN 1445
+ ++ + ++A+ + + IW E ++ + E K
Sbjct: 915 ---YSYKQSLNMAAVGITENVKGDAKKFEIW---------YNAREEVYIVQAPTPEIKAA 962
Query: 1446 IVKVIRSILRENFR--RHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKNSSS 1503
V IR +L + R LE++ + +PL S +SR++K L+ +
Sbjct: 963 WVNEIRKVLTSQLQACREASQHRALEQS---QSLPLPAPTSTSPSRGNSRNIKKLEERKT 1019
Query: 1504 NEWT-------------GETGKGTLLDS-------DEGSLSSGTQSSGCPTAE--GRQDS 1541
+ + E GKG S D+G SS + AE G
Sbjct: 1020 DPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGP 1079
Query: 1542 KSTSPGKY 1549
K PGKY
Sbjct: 1080 KKLVPGKY 1087
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 84.3 bits (207), Expect = 9e-16
Identities = 116/488 (23%), Positives = 201/488 (41%), Gaps = 99/488 (20%)
Query: 1101 RKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFL------TQDEMESLFGSLPEMLEFQ 1154
R V+ EL+DTE++YV++L C+ E Y + N ++ + LFG++ E+ F
Sbjct: 607 RHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFH 666
Query: 1155 -KVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQK 1213
++FL LE N + P +G FL + F++Y +C N + +
Sbjct: 667 NRIFLRELE---------NYTDCPEL-------VGRCFLERMEDFQIYEKYCQNKPRSES 710
Query: 1214 VLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEH 1273
L R +D F F + + H +L+SYL+KPVQR+ KY LLLKE++ + + E
Sbjct: 711 -LWRQCSDCPF--FQECQRKL-DHKLSLDSYLLKPVQRITKYQLLLKEMLKYS-RNCEGA 765
Query: 1274 YHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVS 1333
L EAL ++ + +N+ + G +D + + +G+LLM + S
Sbjct: 766 EDLQEALSSILGILKAVNDSMHLIAITG--YDGNLGD------------LGKLLMQGSFS 811
Query: 1334 -WLNPFLSLGKAR-----KDLELTVFVFKRAVILVYK--ENCKLKKKLPSNSRPAHNSTD 1385
W + K + K ++ +F+ ++AV+ K EN + +K PS
Sbjct: 812 VWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPS---------- 861
Query: 1386 LDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTN 1445
+ ++ + ++A+ + + IW E ++ + E K
Sbjct: 862 ---YSYKQSLNMAAVGITENVKGDAKKFEIW---------YNAREEVYIVQAPTPEIKAA 909
Query: 1446 IVKVIRSILRENFR--RHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKNSSS 1503
V IR +L + R LE++ + +PL S +SR++K L+ +
Sbjct: 910 WVNEIRKVLTSQLQACREASQHRALEQS---QSLPLPAPTSTSPSRGNSRNIKKLEERKT 966
Query: 1504 NEWT-------------GETGKGTLLDS-------DEGSLSSGTQSSGCPTAE--GRQDS 1541
+ + E GKG S D+G SS + AE G
Sbjct: 967 DPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGP 1026
Query: 1542 KSTSPGKY 1549
K PGKY
Sbjct: 1027 KKLVPGKY 1034
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 82.8 bits (203), Expect = 3e-15
Identities = 106/447 (23%), Positives = 189/447 (42%), Gaps = 74/447 (16%)
Query: 1006 QLLEEFLDNFKKNTANDFSNVPDITTGLKRSQTDGTLDQVSHREKMEQTFRSAEQITALC 1065
+LL + D F + + + T + + D +L +R +E+ +
Sbjct: 1197 KLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSS 1256
Query: 1066 RSFNDSQANGMEGPRENQDPPPRPLARHLSD-----ADRLRKVIQELVDTEKSYVKDLSC 1120
+S Q + + + R A L++ A R ++ EL+ TEK+YV+DL
Sbjct: 1257 KSL---QLDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRE 1313
Query: 1121 LFELYLEPLQNETF-----LTQDEMESLFGSLPEMLEFQK-VFLETLEDGISASSDFNTL 1174
+ YL + + + E+ +FG++ E+ EF +FL+ LE
Sbjct: 1314 CMDTYLWEMTSGVEEIPPGIVNKEL-IIFGNMQEIYEFHNNIFLKELE------------ 1360
Query: 1175 ETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHI-KVQKVLERAKTDKAFKAFLDARNP 1233
++ +L +G F+ +AD F++Y +C N Q +LE A + + D
Sbjct: 1361 ----KYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGS------YFDEIQQ 1410
Query: 1234 TKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEM 1293
++++ SYLIKPVQR+ KY LLLKEL++ ++ E + + L+ M V N+
Sbjct: 1411 RHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGE---IKDGLEVMLSVPKRANDA 1467
Query: 1294 QKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVF 1353
+ G FD+ + Q GEL++ + +P + K R E +F
Sbjct: 1468 MHLSMLEG--FDENIESQ------------GELILQESFQVWDPKTLIRKGR---ERHLF 1510
Query: 1354 VFKRAVILVYKENCK---------LKKKLPSNSRPAHNSTDLDPFKFR-WL--IPISALQ 1401
+F+ + LV+ + K K KL ++ + DP KF W+ P S +
Sbjct: 1511 LFEMS--LVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNK 1568
Query: 1402 VRLGNPAGTENNSIWELIHTKSEIEGR 1428
+ L + EN W + H + I+ R
Sbjct: 1569 IVL-KASSIENKQDW-IKHIREVIQER 1593
Score = 74.7 bits (182), Expect = 7e-13
Identities = 72/274 (26%), Positives = 121/274 (44%), Gaps = 44/274 (16%)
Query: 1092 RHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMES----LFGSL 1147
R S R V+QELV+TE+ YV+DL + E Y+ ++ + D+M+ +FG++
Sbjct: 1962 RKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDG--VPDDMKGKDKIVFGNI 2019
Query: 1148 PEMLEFQK-VFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCA 1206
++ ++ + FL LE LE P + LG F+ + +Y +C
Sbjct: 2020 HQIYDWHRDFFLGELE---------KCLEDPEK-------LGSLFVKHERRLHMYIAYCQ 2063
Query: 1207 NHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLT 1266
N K + ++ + F + H L LIKPVQR++KY LLLK+ + +
Sbjct: 2064 NKPKSEHIVS-----EYIDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYS 2118
Query: 1267 DQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGEL 1326
+ S + L A++ M V N+M + G FD + Q G+L
Sbjct: 2119 KKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQG--FDGKIVAQ------------GKL 2164
Query: 1327 LMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVI 1360
L+ T +L G + E +F+F++ VI
Sbjct: 2165 LLQDT--FLVTDQDAGLLPRCRERRIFLFEQIVI 2196
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 80.1 bits (196), Expect = 2e-14
Identities = 98/389 (25%), Positives = 167/389 (42%), Gaps = 94/389 (24%)
Query: 1103 VIQELVDTEKSYVKDLSCLFELYLEPLQNET------FLTQDEMESLFGSLPEMLEFQK- 1155
++ EL+ TEK+YV+DL E YL + + L ++ + +FG++ E+ +F
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHI--IFGNIQEIYDFHNN 1342
Query: 1156 VFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKV-QKV 1214
+FL+ LE ++ +L +G F+ +AD F++Y +C N Q +
Sbjct: 1343 IFLKELE----------------KYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLI 1386
Query: 1215 LERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHY 1274
LE A T F D ++++ SYLIKPVQR+ KY LLLKEL++ ++ E
Sbjct: 1387 LEHAGT------FFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGE-- 1438
Query: 1275 HLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSW 1334
L + L+ M V N+ + G FD+ + Q GEL++
Sbjct: 1439 -LKDGLEVMLSVPKKANDAMHVSMLEG--FDENLDVQ------------GELILQDAFQV 1483
Query: 1335 LNPFLSLGKARKDLELTVFVFKRAVILVYKENCK---------LKKKLPSNSRPAHNSTD 1385
+P + K R E +F+F+ + LV+ + K K KL ++ +
Sbjct: 1484 WDPKSLIRKGR---ERHLFLFE--ISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVE 1538
Query: 1386 LDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTN 1445
DP KF + G ++N ++ L S+ E+K
Sbjct: 1539 GDPCKF---------ALWSGRTPSSDNKTV-------------------LKASNIETKQE 1570
Query: 1446 IVKVIRSILRE---NFRRHIKCELPLEKT 1471
+K IR +++E + + +K L L KT
Sbjct: 1571 WIKNIREVIQERIIHLKGALKEPLQLPKT 1599
Score = 73.2 bits (178), Expect = 2e-12
Identities = 79/320 (24%), Positives = 134/320 (41%), Gaps = 53/320 (16%)
Query: 1085 PPPRPLARHLSDADRLRK-VIQELVDTEKSYVKDLSCLFELYLEPLQN----ETFLTQDE 1139
PP P + A R R V+ ELV TEK YVKDL + E +++ ++ E +D+
Sbjct: 1914 PPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDK 1973
Query: 1140 MESLFGSLPEMLEFQK-VFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHF 1198
+ +FG++ ++ ++ K FL LE I L F+ +
Sbjct: 1974 I--VFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQL----------------FIKHERKL 2015
Query: 1199 KLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLL 1258
+Y +C N + + ++ + A+ + TL +LIKP+QR+ KY LL
Sbjct: 2016 HIYVWYCQNKPRSEYIVAE------YDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLL 2069
Query: 1259 LKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEV 1318
LK+ + +++ E + +A++ M V N+M + G E
Sbjct: 2070 LKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQGF--------------EG 2115
Query: 1319 TELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVI---LVYKENC----KLKK 1371
T + G+LL T + L G + E VF+F++ VI L+ K + K+
Sbjct: 2116 TLTAQGKLLQQDTFYVIE--LDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKR 2173
Query: 1372 KLPSNSRPAHNSTDLDPFKF 1391
+ N + D DP KF
Sbjct: 2174 SIKMNYLVLEENVDNDPCKF 2193
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 80.1 bits (196), Expect = 2e-14
Identities = 98/389 (25%), Positives = 167/389 (42%), Gaps = 94/389 (24%)
Query: 1103 VIQELVDTEKSYVKDLSCLFELYLEPLQNET------FLTQDEMESLFGSLPEMLEFQK- 1155
++ EL+ TEK+YV+DL E YL + + L ++ + +FG++ E+ +F
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHI--IFGNIQEIYDFHNN 1342
Query: 1156 VFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKV-QKV 1214
+FL+ LE ++ +L +G F+ +AD F++Y +C N Q +
Sbjct: 1343 IFLKELE----------------KYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLI 1386
Query: 1215 LERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHY 1274
LE A T F D ++++ SYLIKPVQR+ KY LLLKEL++ ++ E
Sbjct: 1387 LEHAGT------FFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGE-- 1438
Query: 1275 HLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSW 1334
L + L+ M V N+ + G FD+ + Q GEL++
Sbjct: 1439 -LKDGLEVMLSVPKKANDAMHVSMLEG--FDENLDVQ------------GELILQDAFQV 1483
Query: 1335 LNPFLSLGKARKDLELTVFVFKRAVILVYKENCK---------LKKKLPSNSRPAHNSTD 1385
+P + K R E +F+F+ + LV+ + K K KL ++ +
Sbjct: 1484 WDPKSLIRKGR---ERHLFLFE--ISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVE 1538
Query: 1386 LDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTN 1445
DP KF + G ++N ++ L S+ E+K
Sbjct: 1539 GDPCKF---------ALWSGRTPSSDNKTV-------------------LKASNIETKQE 1570
Query: 1446 IVKVIRSILRE---NFRRHIKCELPLEKT 1471
+K IR +++E + + +K L L KT
Sbjct: 1571 WIKNIREVIQERIIHLKGALKEPLQLPKT 1599
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 79.3 bits (194), Expect = 3e-14
Identities = 84/378 (22%), Positives = 166/378 (43%), Gaps = 46/378 (12%)
Query: 1101 RKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLET 1160
++VI EL TE S+++ L L ++ + ++ E + ++E+ LF +LPE++E + E
Sbjct: 776 QEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEA 835
Query: 1161 L----EDG--ISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKV 1214
+ E+G I SD R+ L + F Y I ++ +
Sbjct: 836 MKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQS------------IALELI 883
Query: 1215 LERAKTDKAFKAFL-DARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEH 1273
+ + + F+ F+ +A + + L +I +QR+ KYPLLL+ ++ T+ + EH
Sbjct: 884 KTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEH 943
Query: 1274 YHLTEALKAMEKVASHINEMQKIYED------YGTVFDQLVAEQS----GTEKEVTELSM 1323
L A ++ ++NE K E+ Y D E++ E + +L+
Sbjct: 944 EKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTT 1003
Query: 1324 GELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNS 1383
+++ ++W + K K L+L V + + ++L+ K++ KL L +S+ A S
Sbjct: 1004 RKMIHEGPLTW-----RISK-DKTLDLHVLLLEDLLVLLQKQDEKL--LLKCHSKTAVGS 1055
Query: 1384 TDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESK 1443
+D + P+ L L T+ + + + +K P I++L S K
Sbjct: 1056 SD----SKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKL----GPPQIYELVALTSSDK 1107
Query: 1444 TNIVKVIRSILRENFRRH 1461
++++ +R N RH
Sbjct: 1108 NTWMELLEEAVR-NATRH 1124
Score = 32.3 bits (72), Expect = 4.0
Identities = 25/102 (24%), Positives = 45/102 (44%), Gaps = 8/102 (7%)
Query: 902 FGFAVTAQVDERQHLSRIFISDVLPDGLAYGEGLRKGNEIMTLNGEAVSDLD-LKQMEAL 960
FGF V+ + + V P G A G+++G+ I+ +NG V++ L+ ++ +
Sbjct: 57 FGFTVSGD-------RIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLI 109
Query: 961 FSEKSVGLTLIARPPDTKATLCTSWSDSDLFSRDQKSLLPPP 1002
S V LTL+ P + S + S++P P
Sbjct: 110 KSGAYVALTLLGSSPSSMGISGLQQDPSPAGAPRITSVIPSP 151
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 79.3 bits (194), Expect = 3e-14
Identities = 84/378 (22%), Positives = 166/378 (43%), Gaps = 46/378 (12%)
Query: 1101 RKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLET 1160
++VI EL TE S+++ L L ++ + ++ E + ++E+ LF +LPE++E + E
Sbjct: 736 QEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEA 795
Query: 1161 L----EDG--ISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKV 1214
+ E+G I SD R+ L + F Y I ++ +
Sbjct: 796 MKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQS------------IALELI 843
Query: 1215 LERAKTDKAFKAFL-DARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEH 1273
+ + + F+ F+ +A + + L +I +QR+ KYPLLL+ ++ T+ + EH
Sbjct: 844 KTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEH 903
Query: 1274 YHLTEALKAMEKVASHINEMQKIYED------YGTVFDQLVAEQS----GTEKEVTELSM 1323
L A ++ ++NE K E+ Y D E++ E + +L+
Sbjct: 904 EKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTT 963
Query: 1324 GELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNS 1383
+++ ++W + K K L+L V + + ++L+ K++ KL L +S+ A S
Sbjct: 964 RKMIHEGPLTW-----RISK-DKTLDLHVLLLEDLLVLLQKQDEKL--LLKCHSKTAVGS 1015
Query: 1384 TDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESK 1443
+D + P+ L L T+ + + + +K P I++L S K
Sbjct: 1016 SD----SKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKL----GPPQIYELVALTSSDK 1067
Query: 1444 TNIVKVIRSILRENFRRH 1461
++++ +R N RH
Sbjct: 1068 NTWMELLEEAVR-NATRH 1084
Score = 32.3 bits (72), Expect = 4.0
Identities = 25/102 (24%), Positives = 45/102 (44%), Gaps = 8/102 (7%)
Query: 902 FGFAVTAQVDERQHLSRIFISDVLPDGLAYGEGLRKGNEIMTLNGEAVSDLD-LKQMEAL 960
FGF V+ + + V P G A G+++G+ I+ +NG V++ L+ ++ +
Sbjct: 57 FGFTVSGD-------RIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLI 109
Query: 961 FSEKSVGLTLIARPPDTKATLCTSWSDSDLFSRDQKSLLPPP 1002
S V LTL+ P + S + S++P P
Sbjct: 110 KSGAYVALTLLGSSPSSMGISGLQQDPSPAGAPRITSVIPSP 151
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 79.3 bits (194), Expect = 3e-14
Identities = 72/269 (26%), Positives = 127/269 (47%), Gaps = 28/269 (10%)
Query: 1104 IQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLED 1163
I EL+ TE+ Y+ DL + E++ + + FLT+ EM +F + E++ L+ L
Sbjct: 1187 IHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRV 1246
Query: 1164 GISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKA 1223
+ + P Q +G H + Y FC+ + +L++ KTD+
Sbjct: 1247 RKKTGGE----KMPVQM------IGDILAAELSHMQAYIRFCSCQLNGAALLQQ-KTDED 1295
Query: 1224 --FKAFLD--ARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEA 1279
FK FL A +P + L S+L+KP+QR+ +YPLL++ ++ T + +H L A
Sbjct: 1296 TDFKEFLKKLASDP-RCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLA 1354
Query: 1280 LKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFL 1339
L+ E++ S +NE + E+ D+L Q+ + E +L+ +S + L P
Sbjct: 1355 LERAEELCSQVNEGVREKEN----SDRLEWIQAHVQ---CEGLAEQLIFNSLTNCLGPRK 1407
Query: 1340 -----SLGKARKDLELTVFVFKRAVILVY 1363
L K + + EL F+F ++L Y
Sbjct: 1408 LLHSGKLYKTKSNKELHGFLFNDFLLLTY 1436
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 79.3 bits (194), Expect = 3e-14
Identities = 72/269 (26%), Positives = 127/269 (47%), Gaps = 28/269 (10%)
Query: 1104 IQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLED 1163
I EL+ TE+ Y+ DL + E++ + + FLT+ EM +F + E++ L+ L
Sbjct: 1214 IHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRV 1273
Query: 1164 GISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKA 1223
+ + P Q +G H + Y FC+ + +L++ KTD+
Sbjct: 1274 RKKTGGE----KMPVQM------IGDILAAELSHMQAYIRFCSCQLNGAALLQQ-KTDED 1322
Query: 1224 --FKAFLD--ARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEA 1279
FK FL A +P + L S+L+KP+QR+ +YPLL++ ++ T + +H L A
Sbjct: 1323 TDFKEFLKKLASDP-RCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLA 1381
Query: 1280 LKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFL 1339
L+ E++ S +NE + E+ D+L Q+ + E +L+ +S + L P
Sbjct: 1382 LERAEELCSQVNEGVREKEN----SDRLEWIQAHVQ---CEGLAEQLIFNSLTNCLGPRK 1434
Query: 1340 -----SLGKARKDLELTVFVFKRAVILVY 1363
L K + + EL F+F ++L Y
Sbjct: 1435 LLHSGKLYKTKSNKELHGFLFNDFLLLTY 1463
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 [Homo
sapiens]
Length = 847
Score = 79.0 bits (193), Expect = 4e-14
Identities = 81/340 (23%), Positives = 148/340 (43%), Gaps = 78/340 (22%)
Query: 1104 IQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLED 1163
+ E+ TE+ Y + L + + ++ PL+ FLT E +S+F ++PE+++ + ++ + D
Sbjct: 197 LAEIKQTEEKYTETLESIEKYFMAPLKR--FLTAAEFDSVFINIPELVKLHRNLMQEIHD 254
Query: 1164 GISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLER-AKTDK 1222
I +D N + F+ Y + +Y +C+ L+ +KT +
Sbjct: 255 SIVNKNDQNLYQV--------------FINYKERLVIYGQYCSGVESAISSLDYISKTKE 300
Query: 1223 AFKAFLDARNPTKQHSS-TLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALK 1281
K L+ + + TL L+ P+QRVLKY LLL+ELV T +E+ +L AL
Sbjct: 301 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEK-ANLKLALD 359
Query: 1282 AMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSL 1341
AM+ +A ++NE+++ E T +E+ + + S + P L
Sbjct: 360 AMKDLAQYVNEVKRDNE---------------TLREIKQFQL------SIENLNQPVLLF 398
Query: 1342 GKARKDLELT-------------VFVFKRAVILVYKENCKLKKKLPSNSRPAHNSTDLDP 1388
G+ + D E+ +F+F AVI+ CK K D
Sbjct: 399 GRPQGDGEIRITTLDKHTKQERHIFLFDLAVIV-----CKRKG---------------DN 438
Query: 1389 FKFRWLIPISALQVRLGNPAGTENNSIWE----LIHTKSE 1424
++ + +I + ++ NP + N W LIHT+ +
Sbjct: 439 YEMKEIIDLQQYKI-ANNPTTDKENKKWSYGFYLIHTQGQ 477
>gi|21735572 epithelial cell transforming sequence 2 oncogene protein
[Homo sapiens]
Length = 883
Score = 79.0 bits (193), Expect = 4e-14
Identities = 119/487 (24%), Positives = 201/487 (41%), Gaps = 53/487 (10%)
Query: 1102 KVIQELVDTEKSYVKDLSCLFELYLEPLQNE-----TFLTQDEMESLFGSLPEMLEFQKV 1156
+V +EL TE +YV L+ + +L+ PL+ E L +E++++FGS+P++ +
Sbjct: 424 QVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTK 483
Query: 1157 FLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA-DHFKLYSGFCANHIKVQK-- 1213
+ LED I + S+G FL Y+ D K Y F N ++ K
Sbjct: 484 IKDDLEDLIVNWDESK-------------SIGDIFLKYSKDLVKTYPPF-VNFFEMSKET 529
Query: 1214 VLERAKTDKAFKAFLDARNPTKQHS-STLESYLIKPVQRVLKYPLLLKELVSLTDQESEE 1272
+++ K F AFL + +L LI+PVQR+ LLL +L T E+ +
Sbjct: 530 IIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPD 589
Query: 1273 HYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTV 1332
L +A+ ++++V +HINE ++ E +FD +V E G + L H ++
Sbjct: 590 KSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFD-VVYEVDGCPANL-------LSSHRSL 641
Query: 1333 SWLNPFLSLGKARKDL--ELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNST-DLDPF 1389
+SLG+ D ++T+F+F + E + + K+ R H T
Sbjct: 642 VQRVETISLGEHPCDRGEQVTLFLFNDCL-----EIARKRHKVIGTFRSPHGQTRPPASL 696
Query: 1390 KFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTNIVK- 1448
K L+P+S ++ L + ++ + L+ + FQ+ SD K N +K
Sbjct: 697 KHIHLMPLSQIKKVLDIRETEDCHNAFALLVRPPTEQANVLLSFQM-TSDELPKENWLKM 755
Query: 1449 ----VIRSILRENFRRHIKCELP--LEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKNSS 1502
V +I + + I P E KD L A A ++ K + +
Sbjct: 756 LCRHVANTICKADAENLIYTADPESFEVNTKDMDSTLSR-----ASRAIKKTSKKVTRAF 810
Query: 1503 SNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFADNLI 1562
S T + L + GS+ + SS R S S+ G P P L
Sbjct: 811 SFSKTPKRALRRALMTSHGSVEGRSPSSNDKHVMSRLSSTSSLAG-IPSPSLVSLPSFFE 869
Query: 1563 KESDILS 1569
+ S LS
Sbjct: 870 RRSHTLS 876
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 78.2 bits (191), Expect = 6e-14
Identities = 64/247 (25%), Positives = 114/247 (46%), Gaps = 21/247 (8%)
Query: 1052 EQTFRSAEQITALCRSFNDSQANGMEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTE 1111
+Q + E+ L + +A G E + P + +++ D+ ++E+ TE
Sbjct: 147 DQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTE 206
Query: 1112 KSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDF 1171
+ Y L + + +L+PLQ FL ++E +F ++ ++L FL+ +++ +
Sbjct: 207 EKYTDTLGSIQQHFLKPLQR--FLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAA 264
Query: 1172 NTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLER---AKTDKAFKAFL 1228
N + F+ Y + F +Y +C+ K L+R A+ D K
Sbjct: 265 NLYQV--------------FIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMK-LE 309
Query: 1229 DARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVAS 1288
+ TL L+ P+QRVLKY LLL+ELV T QE+ E +L AL AM +A
Sbjct: 310 ECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHT-QEAMEKENLRLALDAMRDLAQ 368
Query: 1289 HINEMQK 1295
+NE+++
Sbjct: 369 CVNEVKR 375
>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 78.2 bits (191), Expect = 6e-14
Identities = 54/211 (25%), Positives = 97/211 (45%), Gaps = 16/211 (7%)
Query: 1086 PPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFG 1145
PP+ + V+Q +++TE Y K+L + YL PLQ L+ + L G
Sbjct: 80 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMG 139
Query: 1146 SLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGF 1204
+L E+ FQ++ +++LE+ + P ++ +GG FL K LY +
Sbjct: 140 NLEEICSFQQMLVQSLEE---------CTKLPEAQQR----VGGCFLNLMPQMKTLYLTY 186
Query: 1205 CANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVS 1264
CANH VL + + F++ + + L + L KP R+ KYP LLKEL
Sbjct: 187 CANHPSAVNVL--TEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELER 244
Query: 1265 LTDQESEEHYHLTEALKAMEKVASHINEMQK 1295
+ + + +++ A + +++ E++K
Sbjct: 245 HMEDYHTDRQDIQKSMAAFKNLSAQCQEVRK 275
>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
sapiens]
Length = 753
Score = 78.2 bits (191), Expect = 6e-14
Identities = 54/211 (25%), Positives = 97/211 (45%), Gaps = 16/211 (7%)
Query: 1086 PPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFG 1145
PP+ + V+Q +++TE Y K+L + YL PLQ L+ + L G
Sbjct: 208 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMG 267
Query: 1146 SLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGF 1204
+L E+ FQ++ +++LE+ + P ++ +GG FL K LY +
Sbjct: 268 NLEEICSFQQMLVQSLEE---------CTKLPEAQQR----VGGCFLNLMPQMKTLYLTY 314
Query: 1205 CANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVS 1264
CANH VL + + F++ + + L + L KP R+ KYP LLKEL
Sbjct: 315 CANHPSAVNVL--TEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELER 372
Query: 1265 LTDQESEEHYHLTEALKAMEKVASHINEMQK 1295
+ + + +++ A + +++ E++K
Sbjct: 373 HMEDYHTDRQDIQKSMAAFKNLSAQCQEVRK 403
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,650,161
Number of Sequences: 37866
Number of extensions: 3177513
Number of successful extensions: 9792
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 182
Number of HSP's that attempted gapping in prelim test: 9265
Number of HSP's gapped (non-prelim): 599
length of query: 1701
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1585
effective length of database: 13,855,062
effective search space: 21960273270
effective search space used: 21960273270
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.