Search of human proteins with 58331111

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|58331111 ankyrin repeat domain 16 isoform a [Homo sapiens]
         (361 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|58331113 ankyrin repeat domain 16 isoform a [Homo sapiens]         737   0.0  
gi|58331111 ankyrin repeat domain 16 isoform a [Homo sapiens]         737   0.0  
gi|58331117 ankyrin repeat domain 16 isoform c [Homo sapiens]         585   e-167
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   134   1e-31
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   132   4e-31
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       132   6e-31
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        132   6e-31
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        132   6e-31
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        132   6e-31
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        132   6e-31
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        128   7e-30
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    125   4e-29
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       123   2e-28
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        123   2e-28
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        123   2e-28
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho...   122   6e-28
gi|110431370 espin [Homo sapiens]                                     119   4e-27
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   115   6e-26
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   114   2e-25
gi|223634006 hypothetical protein LOC441869 [Homo sapiens]            108   1e-23
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   107   2e-23
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   107   2e-23
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   106   3e-23
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    106   3e-23
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  106   4e-23
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...   105   5e-23
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...   105   5e-23
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   105   8e-23
gi|10863929 ribonuclease L [Homo sapiens]                             104   1e-22
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   100   3e-21

>gi|58331113 ankyrin repeat domain 16 isoform a [Homo sapiens]
          Length = 361

 Score =  737 bits (1902), Expect = 0.0
 Identities = 361/361 (100%), Positives = 361/361 (100%)

Query: 1   MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW 60
           MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW
Sbjct: 1   MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW 60

Query: 61  GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI 120
           GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI
Sbjct: 61  GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI 120

Query: 121 QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM 180
           QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM
Sbjct: 121 QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM 180

Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
           HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA
Sbjct: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240

Query: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADI 300
           QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADI
Sbjct: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADI 300

Query: 301 NSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDITGTLAQQLPRRADVLQGSGHSAM 360
           NSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDITGTLAQQLPRRADVLQGSGHSAM
Sbjct: 301 NSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDITGTLAQQLPRRADVLQGSGHSAM 360

Query: 361 T 361
           T
Sbjct: 361 T 361


>gi|58331111 ankyrin repeat domain 16 isoform a [Homo sapiens]
          Length = 361

 Score =  737 bits (1902), Expect = 0.0
 Identities = 361/361 (100%), Positives = 361/361 (100%)

Query: 1   MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW 60
           MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW
Sbjct: 1   MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW 60

Query: 61  GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI 120
           GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI
Sbjct: 61  GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI 120

Query: 121 QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM 180
           QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM
Sbjct: 121 QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM 180

Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
           HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA
Sbjct: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240

Query: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADI 300
           QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADI
Sbjct: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADI 300

Query: 301 NSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDITGTLAQQLPRRADVLQGSGHSAM 360
           NSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDITGTLAQQLPRRADVLQGSGHSAM
Sbjct: 301 NSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDITGTLAQQLPRRADVLQGSGHSAM 360

Query: 361 T 361
           T
Sbjct: 361 T 361


>gi|58331117 ankyrin repeat domain 16 isoform c [Homo sapiens]
          Length = 304

 Score =  585 bits (1508), Expect = e-167
 Identities = 283/283 (100%), Positives = 283/283 (100%)

Query: 1   MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW 60
           MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW
Sbjct: 1   MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW 60

Query: 61  GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI 120
           GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI
Sbjct: 61  GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI 120

Query: 121 QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM 180
           QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM
Sbjct: 121 QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM 180

Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
           HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA
Sbjct: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240

Query: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAK 283
           QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAK
Sbjct: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAK 283



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 62/218 (28%), Positives = 96/218 (44%), Gaps = 22/218 (10%)

Query: 142 HIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKR-----CQY 196
           H A+R G   +L YL        +  ++  + PLH AA  GH + V+ LL R     C  
Sbjct: 42  HCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLK 101

Query: 197 EPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIR 256
           + D+      T LM A    ++ V + L+ EHGA    ++  G  + H A+  G    ++
Sbjct: 102 KADW------TPLMMACTRKNLGVIQELV-EHGANPLLKNKDGWNSFHIASREGDPLILQ 154

Query: 257 FLVSELGVDVDVRATSTHL--TALHYAAKEGHTSTIQTLLS-LGADINSKDEKNRSALHL 313
           +L++   V      T + +  T LH AA  GH   ++ LL     + + +D    +AL  
Sbjct: 155 YLLT---VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMD 211

Query: 314 ACAGQHLACAKFLL--QSGLKDSEDITGTLAQQLPRRA 349
           A    H+  A+ LL        +ED  G  AQ L R A
Sbjct: 212 AIQCGHIDVARLLLDEHGACLSAEDSLG--AQALHRAA 247



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 29/109 (26%), Positives = 50/109 (45%), Gaps = 1/109 (0%)

Query: 222 RLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYA 281
           R L +E  A        G   LH AA  G  + + +L    G+D++      +   LH A
Sbjct: 20  RALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEA-TNRDYKRPLHEA 78

Query: 282 AKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
           A  GH   ++ LL  GA ++   + + + L +AC  ++L   + L++ G
Sbjct: 79  ASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHG 127


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  134 bits (338), Expect = 1e-31
 Identities = 97/314 (30%), Positives = 160/314 (50%), Gaps = 17/314 (5%)

Query: 33  PGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLG 92
           P   G T LH AA  G+ + L  L    G D    ++  + PLH AA+  +  C+  L+G
Sbjct: 401 PDDFGRTCLHAAAAGGNLECLNLLLNT-GADFNKKDKFGRSPLHYAAANCNYQCLFALVG 459

Query: 93  RGAAVDCLKKADWTPLMMACTRKNLG-VIQELVEHGANPLLKNKDGWNSFHIASREGDPL 151
            GA+V+ L +   TPL  A T    G  ++ L+ + ANP +++K G+N+ H ++  G  L
Sbjct: 460 SGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRL 519

Query: 152 ILQYLLTVCP-----------GAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDY 200
            LQ + +  P               ++++   +PLH AA HGH +A++VL++    + D 
Sbjct: 520 CLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSL-LDLDV 578

Query: 201 RDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLV- 259
           R++ G T L  A   GH++   +L+++  + L  +  L    +H AA  G  E +R L+ 
Sbjct: 579 RNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIG 638

Query: 260 -SELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQ 318
            +E    VD++  +   T L  +   GHT  + +LL+ GA++++KD+  R+ALH      
Sbjct: 639 NAEPQNAVDIQDGNGQ-TPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTG 697

Query: 319 HLACAKFLLQSGLK 332
           H  C   LLQ G K
Sbjct: 698 HEECVDALLQHGAK 711



 Score =  120 bits (301), Expect = 2e-27
 Identities = 92/295 (31%), Positives = 140/295 (47%), Gaps = 5/295 (1%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           AG T LH AA  GH +++  L    G +I A ++  +R +H AA MGH + V+ L+  GA
Sbjct: 139 AGRTALHHAAFSGHGEMVKLLLSR-GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 197

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
            V C  K  +TPL  A +   + V++ L++ G +    N  G    H+A   G  +++  
Sbjct: 198 EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNE 257

Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
           L+  C      +++   TPLH AA   H      LL     + + +   G T L      
Sbjct: 258 LID-CGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALH 316

Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
           G    ++ ++ + GA +  ED  G   LH AA  G +  I  L++  G D   R     +
Sbjct: 317 GRFSRSQTII-QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS-GADTAKRGIH-GM 373

Query: 276 TALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
             LH AA  G +   + LLS G DI++ D+  R+ LH A AG +L C   LL +G
Sbjct: 374 FPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTG 428



 Score =  108 bits (271), Expect = 6e-24
 Identities = 84/270 (31%), Positives = 133/270 (49%), Gaps = 8/270 (2%)

Query: 63  DIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADW-TPLMMACTRKNLGVIQ 121
           D+   + + + PLH AA +G  + +  L+  GA V+  K + W TPL  A    +   +Q
Sbjct: 33  DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNA-KDSKWLTPLHRAVASCSEEAVQ 91

Query: 122 ELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMH 181
            L++H A+   ++K+     HIA+        + L+ +         +  RT LH AA  
Sbjct: 92  VLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNV-NVSDRAGRTALHHAAFS 150

Query: 182 GHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQ 241
           GH E VK+LL R      + D     A+  A   GHI+V +LL+  HGA ++ +D     
Sbjct: 151 GHGEMVKLLLSRGANINAF-DKKDRRAIHWAAYMGHIEVVKLLV-SHGAEVTCKDKKSYT 208

Query: 242 ALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADIN 301
            LH AA +G    +++L+ +LGVD++    +   T LH A   G    +  L+  GA +N
Sbjct: 209 PLHAAASSGMISVVKYLL-DLGVDMN-EPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266

Query: 302 SKDEKNRSALHLACAGQHLA-CAKFLLQSG 330
            K+EK  + LH A A  H A C + L+ +G
Sbjct: 267 QKNEKGFTPLHFAAASTHGALCLELLVGNG 296



 Score =  102 bits (255), Expect = 4e-22
 Identities = 93/300 (31%), Positives = 143/300 (47%), Gaps = 17/300 (5%)

Query: 39  TLLHCAARHGHRDVLAYL---AEAWG-MDIEATNRDYKRPLHEAASMGHRDCVRYLLGRG 94
           T +H AA +GH + L  L   AE    +DI+  N   + PL  +   GH DCV  LL +G
Sbjct: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNG--QTPLMLSVLNGHTDCVYSLLNKG 676

Query: 95  AAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQ 154
           A VD   K   T L       +   +  L++HGA  LL++  G    H+++  G   +L 
Sbjct: 677 ANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLG 736

Query: 155 YLLTVCPGA---WKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMD 211
            LL           T      T LH A  +GH   V++LL++  ++    +    + L  
Sbjct: 737 ALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQK--TEGNAFSPLHC 794

Query: 212 AIQCGHIDVARLLLDEHGACL-SAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRA 270
           A+   +   A +L+D  GA + +A DS G   LH AA T   E ++ L+S    +  V +
Sbjct: 795 AVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSH---NAQVNS 851

Query: 271 T-STHLTALHYAAKEGHTSTIQTLL-SLGADINSKDEKNRSALHLACAGQHLACAKFLLQ 328
             ST  T L  AA+ G T+T++ L+ S  A++  +D    +ALHLAC+  H   A  +L+
Sbjct: 852 VDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILE 911



 Score =  102 bits (254), Expect = 5e-22
 Identities = 90/329 (27%), Positives = 132/329 (40%), Gaps = 44/329 (13%)

Query: 41  LHCAARHGHRDVLAYLAEAWGMDIEATN-------------------------------R 69
           LH AA HGH   L  L ++  +D++  N                               +
Sbjct: 554 LHLAAYHGHHQALEVLVQSL-LDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVK 612

Query: 70  DY---KRPLHEAASMGHRDCVRYLLGRGA---AVDCLKKADWTPLMMACTRKNLGVIQEL 123
           DY   + P+H AA+ GH +C+R L+G      AVD       TPLM++    +   +  L
Sbjct: 613 DYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSL 672

Query: 124 VEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGH 183
           +  GAN   K+K G  + H  +  G    +  LL         +S+  RTP+H +A  GH
Sbjct: 673 LNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSR-GRTPIHLSAACGH 731

Query: 184 LEAVKVLLKRC---QYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
           +  +  LL+        P   DN G TAL  A   GH     LLL++        +    
Sbjct: 732 IGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE--VFQKTEGNAF 789

Query: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADI 300
             LH A +   + A   L+  LG  +     S   T LH AA   H   +Q LLS  A +
Sbjct: 790 SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQV 849

Query: 301 NSKDEKNRSALHLACAGQHLACAKFLLQS 329
           NS D   ++ L +A         + L+ S
Sbjct: 850 NSVDSTGKTPLMMAAENGQTNTVEMLVSS 878



 Score =  101 bits (251), Expect = 1e-21
 Identities = 89/312 (28%), Positives = 146/312 (46%), Gaps = 8/312 (2%)

Query: 39  TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
           T LH AA  G  +++  L  + G  + A +  +  PLH A +    + V+ LL   A V+
Sbjct: 43  TPLHAAAYLGDAEIIELLILS-GARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN 101

Query: 99  CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLT 158
              K   TPL +A   K +   + LV   +N  + ++ G  + H A+  G   +++ LL+
Sbjct: 102 ARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLS 161

Query: 159 VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHI 218
                   + K RR  +H AA  GH+E VK+L+     E   +D    T L  A   G I
Sbjct: 162 RGANINAFDKKDRRA-IHWAAYMGHIEVVKLLVSH-GAEVTCKDKKSYTPLHAAASSGMI 219

Query: 219 DVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTAL 278
            V + LLD  G  ++  ++ G   LH A   GQD  +  L+ + G  V+ +      T L
Sbjct: 220 SVVKYLLD-LGVDMNEPNAYGNTPLHVACYNGQDVVVNELI-DCGAIVN-QKNEKGFTPL 276

Query: 279 HYAAKEGHTS-TIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG-LKDSED 336
           H+AA   H +  ++ L+  GAD+N K +  ++ LH+       + ++ ++QSG + D ED
Sbjct: 277 HFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCED 336

Query: 337 ITGTLAQQLPRR 348
             G     +  R
Sbjct: 337 KNGNTPLHIAAR 348



 Score =  100 bits (248), Expect = 3e-21
 Identities = 79/269 (29%), Positives = 125/269 (46%), Gaps = 6/269 (2%)

Query: 63  DIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQE 122
           ++  ++R  +  LH AA  GH + V+ LL RGA ++   K D   +  A    ++ V++ 
Sbjct: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191

Query: 123 LVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTE-SKIRRTPLHTAAMH 181
           LV HGA    K+K  +   H A+  G   +++YLL +  G    E +    TPLH A  +
Sbjct: 192 LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDL--GVDMNEPNAYGNTPLHVACYN 249

Query: 182 GHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQ 241
           G    V  L+  C    + ++  G T L  A    H  +   LL  +GA ++ +   G  
Sbjct: 250 GQDVVVNELID-CGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKT 308

Query: 242 ALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADIN 301
            LH  A+ G+    + ++ + G  +D    + + T LH AA+ GH   I TL++ GAD  
Sbjct: 309 PLHMTALHGRFSRSQTII-QSGAVIDCEDKNGN-TPLHIAARYGHELLINTLITSGADTA 366

Query: 302 SKDEKNRSALHLACAGQHLACAKFLLQSG 330
            +       LHLA       C + LL SG
Sbjct: 367 KRGIHGMFPLHLAALSGFSDCCRKLLSSG 395



 Score = 96.3 bits (238), Expect = 4e-20
 Identities = 90/299 (30%), Positives = 137/299 (45%), Gaps = 14/299 (4%)

Query: 33  PGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRD-CVRYLL 91
           P   G+T LH A  +G   V+  L +  G  +   N     PLH AA+  H   C+  L+
Sbjct: 235 PNAYGNTPLHVACYNGQDVVVNELIDC-GAIVNQKNEKGFTPLHFAAASTHGALCLELLV 293

Query: 92  GRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPL 151
           G GA V+   K   TPL M          Q +++ GA    ++K+G    HIA+R G  L
Sbjct: 294 GNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHEL 353

Query: 152 ILQYLLTVCPGAWKTESKIR-RTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALM 210
           ++  L+T   GA   +  I    PLH AA+ G  +  + LL    ++ D  D+ G T L 
Sbjct: 354 LINTLIT--SGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS-SGFDIDTPDDFGRTCLH 410

Query: 211 DAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGV--DVDV 268
            A   G+++   LLL+  GA  + +D  G   LH AA     + +  LV       D+D 
Sbjct: 411 AAAAGGNLECLNLLLNT-GADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDE 469

Query: 269 RATSTHLTALHYAA-KEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFL 326
           R      T LHYAA  +     ++ LL   A+   +D++  +A+H + A  H  C + +
Sbjct: 470 RG----CTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLI 524



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 89/319 (27%), Positives = 140/319 (43%), Gaps = 43/319 (13%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G T L  +  +GH D +  L    G +++A ++  +  LH  A  GH +CV  LL  GA 
Sbjct: 653 GQTPLMLSVLNGHTDCVYSLLNK-GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAK 711

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGA----NPLLKNKDGWNSFHIASREGDPLI 152
                    TP+ ++    ++GV+  L++  A    NP   +  G+ + H A   G    
Sbjct: 712 CLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETC 771

Query: 153 LQYLLTV---------------CP------GAWK-------------TESKIRRTPLHTA 178
           ++ LL                 C       GA +             T+SK  RTPLH A
Sbjct: 772 VELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSK-GRTPLHAA 830

Query: 179 AMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSL 238
           A   H+E +++LL     + +  D+ G T LM A + G  +   +L+    A L+ +D+ 
Sbjct: 831 AFTDHVECLQLLLSH-NAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNS 889

Query: 239 GAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL-TALHYAAKEGHTSTIQTLLSLG 297
              ALH A   G + +   ++ ++     + AT+  L T LH AA+ G T  +Q LL  G
Sbjct: 890 KNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKG 949

Query: 298 ADINSKDEKNRSALHLACA 316
           A + + DE N     LACA
Sbjct: 950 ASVLAVDE-NGYTPALACA 967



 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 104/340 (30%), Positives = 137/340 (40%), Gaps = 26/340 (7%)

Query: 32  CPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLL 91
           C    G+T LH AAR+GH  ++  L  + G D          PLH AA  G  DC R LL
Sbjct: 334 CEDKNGNTPLHIAARYGHELLINTLITS-GADTAKRGIHGMFPLHLAALSGFSDCCRKLL 392

Query: 92  GRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPL 151
             G  +D       T L  A    NL  +  L+  GA+   K+K G +  H A+   +  
Sbjct: 393 SSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQ 452

Query: 152 ILQYLLTVCPGAWKTESKIRR-TPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALM 210
            L  L  V  GA   +   R  TPLH AA           L R    P  RD  G  A+ 
Sbjct: 453 CLFAL--VGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVH 510

Query: 211 DAIQCGHIDVARLLLDEHGACLSAEDS-----------LGAQALHRAAVTGQDEAIRFLV 259
            +   GH    +L+  E    +  E S                LH AA  G  +A+  LV
Sbjct: 511 YSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLV 570

Query: 260 SELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDE-KNRSALHLACAGQ 318
             L +D+DVR  S+  T L  AA +GH   +  L++ GA I  KD    R+ +H A    
Sbjct: 571 QSL-LDLDVR-NSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNG 628

Query: 319 HLACAKFLL----QSGLKDSEDITGTLAQQLPRRADVLQG 354
           H  C + L+         D +D  G    Q P    VL G
Sbjct: 629 HSECLRLLIGNAEPQNAVDIQDGNG----QTPLMLSVLNG 664



 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 64/240 (26%), Positives = 112/240 (46%), Gaps = 13/240 (5%)

Query: 100 LKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTV 159
           LK  D   L+ A    +   ++ L+    +   ++ +     H A+  GD  I++ L+  
Sbjct: 4   LKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILS 63

Query: 160 CPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQ----YEPDYRDNCGVTALMDAIQC 215
                  +SK   TPLH A      EAV+VLLK        + +++    + A   A++C
Sbjct: 64  GARVNAKDSKWL-TPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKC 122

Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
               V  L      + ++  D  G  ALH AA +G  E ++ L+S  G +++        
Sbjct: 123 AEALVPLL------SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSR-GANINAFDKKDR- 174

Query: 276 TALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSE 335
            A+H+AA  GH   ++ L+S GA++  KD+K+ + LH A +   ++  K+LL  G+  +E
Sbjct: 175 RAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNE 234



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 2/82 (2%)

Query: 38  DTLLHCAARHGHR-DVLAYLAEAWGMD-IEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +T LH A   GH    L  L +    + I ATN   + PLH AA  G    V+ LLG+GA
Sbjct: 891 NTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGA 950

Query: 96  AVDCLKKADWTPLMMACTRKNL 117
           +V  + +  +TP +     K++
Sbjct: 951 SVLAVDENGYTPALACAPNKDV 972


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  132 bits (333), Expect = 4e-31
 Identities = 99/295 (33%), Positives = 151/295 (51%), Gaps = 8/295 (2%)

Query: 37   GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
            G T L  AA  GH DV+  L E  G D++ T+ + + PL  AASMGH   V  LL  GAA
Sbjct: 748  GMTPLLVAAYEGHVDVVDLLLEG-GADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAA 806

Query: 97   VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
            VD +     T L +A  + N+ V++ L++ G +   ++  GW   H+A+ EG  LI + L
Sbjct: 807  VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEAL 866

Query: 157  LTVCPGAWKTE-SKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
            +    GA   E     R P   A+  GH + V++LL+  +   D R   G  AL  A   
Sbjct: 867  IE--QGARTNEIDNDGRIPFILASQEGHYDCVQILLEN-KSNIDQRGYDGRNALRVAALE 923

Query: 216  GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
            GH D+  LL   HGA ++ +D+ G   L+  A+  Q     + + E G +V+  + +   
Sbjct: 924  GHRDIVELLF-SHGADVNCKDADGRPTLYILALENQLTMAEYFL-ENGANVEA-SDAEGR 980

Query: 276  TALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
            TALH +  +GH   +Q L++  AD+N+ D + RSAL  A    H+   + L++ G
Sbjct: 981  TALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHG 1035



 Score =  105 bits (263), Expect = 5e-23
 Identities = 97/305 (31%), Positives = 140/305 (45%), Gaps = 13/305 (4%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G T L  AAR GH  V+  L    G +I  T++D    L  AA  GH + V  LL  G  
Sbjct: 578 GHTPLTLAARQGHTKVVNCLIGC-GANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVK 636

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
           VDC      T L  A    +  ++  L++HGA     + +G  +   A+  G   I+++L
Sbjct: 637 VDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHL 696

Query: 157 LTVCPGAWKTESKI-RRTPLHTAAM-----HGHLEAVKVLLKRCQYEPDYRDNCGVTALM 210
           L    GA      +  RT L  AA+      GH   V +L+ R   E D+ D  G+T L+
Sbjct: 697 LD--HGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDR-GAEVDHCDKDGMTPLL 753

Query: 211 DAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRA 270
            A   GH+DV  LLL E GA +   D+ G   L  AA  G    +  L+   G  VD   
Sbjct: 754 VAAYEGHVDVVDLLL-EGGADVDHTDNNGRTPLLAAASMGHASVVNTLLF-WGAAVD-SI 810

Query: 271 TSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
            S   T L  A+ +G+   ++TLL  G D N +D+   + LH+A    H    + L++ G
Sbjct: 811 DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870

Query: 331 LKDSE 335
            + +E
Sbjct: 871 ARTNE 875



 Score =  101 bits (252), Expect = 9e-22
 Identities = 87/265 (32%), Positives = 127/265 (47%), Gaps = 10/265 (3%)

Query: 36   AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
            AG T LH AA  GHR +   L E      E  N D + P   A+  GH DCV+ LL   +
Sbjct: 846  AGWTPLHMAAFEGHRLICEALIEQGARTNEIDN-DGRIPFILASQEGHYDCVQILLENKS 904

Query: 96   AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
             +D         L +A    +  +++ L  HGA+   K+ DG  + +I + E    + +Y
Sbjct: 905  NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEY 964

Query: 156  LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYR--DNCGVTALMDAI 213
             L        ++++  RT LH +   GH+E V+VL+    Y  D    DN   +AL  A 
Sbjct: 965  FLENGANVEASDAE-GRTALHVSCWQGHMEMVQVLIA---YHADVNAADNEKRSALQSAA 1020

Query: 214  QCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATST 273
              GH+ V +LL+ EHGA +    + GA AL  AA  G  + ++ L+ E G D +  A   
Sbjct: 1021 WQGHVKVVQLLI-EHGAVVDHTCNQGATALCIAAQEGHIDVVQVLL-EHGADPN-HADQF 1077

Query: 274  HLTALHYAAKEGHTSTIQTLLSLGA 298
              TA+  AAK GH+  I+ L   GA
Sbjct: 1078 GRTAMRVAAKNGHSQIIKLLEKYGA 1102



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 89/285 (31%), Positives = 129/285 (45%), Gaps = 11/285 (3%)

Query: 61  GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI 120
           G  +   + + +  L  AA  G  D V  L+ RGA ++       TPL +A  + +  V+
Sbjct: 535 GASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVV 594

Query: 121 QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM 180
             L+  GAN    ++DGW +   A+  G   ++  LL         ++   RT L  AA 
Sbjct: 595 NCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADAD-SRTALRAAAW 653

Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
            GH + V  LL+    E +  DN G TAL+ A   GH ++   LLD HGA ++ ED  G 
Sbjct: 654 GGHEDIVLNLLQH-GAEVNKADNEGRTALIAAAYMGHREIVEHLLD-HGAEVNHEDVDGR 711

Query: 241 QALHRAAV-----TGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLS 295
            AL  AA+      G    +  L+ + G +VD       +T L  AA EGH   +  LL 
Sbjct: 712 TALSVAALCVPASKGHASVVSLLI-DRGAEVD-HCDKDGMTPLLVAAYEGHVDVVDLLLE 769

Query: 296 LGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLK-DSEDITG 339
            GAD++  D   R+ L  A +  H +    LL  G   DS D  G
Sbjct: 770 GGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEG 814



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 76/255 (29%), Positives = 116/255 (45%), Gaps = 8/255 (3%)

Query: 80  SMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWN 139
           ++   D +R LL  GA+V+       T L  A    +L V+  LV  GA+  +++  G  
Sbjct: 521 ALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHT 580

Query: 140 SFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPD 199
              +A+R+G   ++  L+  C        +   T L +AA  GH E V  LL     + D
Sbjct: 581 PLTLAARQGHTKVVNCLIG-CGANINHTDQDGWTALRSAAWGGHTEVVSALL-YAGVKVD 638

Query: 200 YRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLV 259
             D    TAL  A   GH D+   LL +HGA ++  D+ G  AL  AA  G  E +  L+
Sbjct: 639 CADADSRTALRAAAWGGHEDIVLNLL-QHGAEVNKADNEGRTALIAAAYMGHREIVEHLL 697

Query: 260 SELG----VDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLAC 315
                    DVD R T+  + AL   A +GH S +  L+  GA+++  D+   + L +A 
Sbjct: 698 DHGAEVNHEDVDGR-TALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAA 756

Query: 316 AGQHLACAKFLLQSG 330
              H+     LL+ G
Sbjct: 757 YEGHVDVVDLLLEGG 771



 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 65/226 (28%), Positives = 101/226 (44%), Gaps = 39/226 (17%)

Query: 34   GPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGR 93
            G  G   L  AA  GHRD+                                  V  L   
Sbjct: 910  GYDGRNALRVAALEGHRDI----------------------------------VELLFSH 935

Query: 94   GAAVDCLKKADWTPLMMACTRKN-LGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLI 152
            GA V+C K AD  P +     +N L + +  +E+GAN    + +G  + H++  +G   +
Sbjct: 936  GADVNC-KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEM 994

Query: 153  LQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDA 212
            +Q L+         +++ +R+ L +AA  GH++ V++L++      D+  N G TAL  A
Sbjct: 995  VQVLIAYHADVNAADNE-KRSALQSAAWQGHVKVVQLLIEHGAV-VDHTCNQGATALCIA 1052

Query: 213  IQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFL 258
             Q GHIDV ++LL EHGA  +  D  G  A+  AA  G  + I+ L
Sbjct: 1053 AQEGHIDVVQVLL-EHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 1097



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 42/114 (36%), Positives = 60/114 (52%), Gaps = 3/114 (2%)

Query: 219 DVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTAL 278
           D  R LLD +GA ++  DS G   L  AA +G  + +  LVS  G D+++     H T L
Sbjct: 526 DSIRTLLD-NGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSR-GADLEIEDAHGH-TPL 582

Query: 279 HYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLK 332
             AA++GHT  +  L+  GA+IN  D+   +AL  A  G H      LL +G+K
Sbjct: 583 TLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVK 636


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  132 bits (331), Expect = 6e-31
 Identities = 95/298 (31%), Positives = 150/298 (50%), Gaps = 11/298 (3%)

Query: 41  LHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCL 100
           LH A++ GH  ++  L     + +E T +     LH AA  G  + VR L+  GA V+  
Sbjct: 82  LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 140

Query: 101 KKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVC 160
            +  +TPL MA    +L V++ L+E+GAN  +  +DG+    +A ++G   ++ +L+   
Sbjct: 141 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-- 198

Query: 161 PGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDV 220
              + T+ K+R   LH AA +       VLL+     PD     G T L  A    +++V
Sbjct: 199 ---YGTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNV 254

Query: 221 ARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHY 280
           A+LLL+  GA ++     G   LH A+  G    +R L+ + G  ++ + T   LT LH 
Sbjct: 255 AQLLLN-RGASVNFTPQNGITPLHIASRRGNVIMVRLLL-DRGAQIETK-TKDELTPLHC 311

Query: 281 AAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDIT 338
           AA+ GH    + LL  GA I +K +   S +H+A  G HL C + LLQ    + +DIT
Sbjct: 312 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD-AEIDDIT 368



 Score =  121 bits (303), Expect = 1e-27
 Identities = 98/298 (32%), Positives = 143/298 (47%), Gaps = 10/298 (3%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +G T LH A+  GH  ++  L +  G     +N   + PLH AA  GH +  +YLL   A
Sbjct: 436 SGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 494

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGD-PLILQ 154
            V+   K D TPL  A    +  +++ L+E+ ANP L    G    HIA+REG    +L 
Sbjct: 495 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 554

Query: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
            L      A  T+     TPLH AA +G +   ++LL+R    P+     G+T L  A+ 
Sbjct: 555 LLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHVAVH 611

Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
             ++D+ +LLL   G+  S   + G   LH AA   Q E  R L+   G      A S  
Sbjct: 612 HNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGG---SANAESVQ 667

Query: 275 -LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGL 331
            +T LH AA+EGH   +  LLS  A+ N  ++   + LHL     H+  A  L++ G+
Sbjct: 668 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 725



 Score =  120 bits (302), Expect = 1e-27
 Identities = 98/291 (33%), Positives = 148/291 (50%), Gaps = 8/291 (2%)

Query: 39  TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
           T LHCAAR+GH  +   L +  G  I+A  ++   P+H AA   H DCVR LL   A +D
Sbjct: 307 TPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 365

Query: 99  CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL- 157
            +     TPL +A    +  V + L++ GA P  +  +G+   HIA ++    +++ LL 
Sbjct: 366 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 425

Query: 158 TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
           T       TES +  TPLH A+  GHL  VK LL+R    P+  +    T L  A + GH
Sbjct: 426 TGASIDAVTESGL--TPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGH 482

Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
            +VA+ LL ++ A ++A+       LH AA  G    ++ L+ E   + ++  T+ H T 
Sbjct: 483 TEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGH-TP 539

Query: 278 LHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQ 328
           LH AA+EGH  T+  LL   A      +K  + LH+A     +  A+ LL+
Sbjct: 540 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 590



 Score =  120 bits (300), Expect = 2e-27
 Identities = 92/280 (32%), Positives = 133/280 (47%), Gaps = 8/280 (2%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           AG T LH AAR GH + +  L E        T + +  PLH AA  G       LL R A
Sbjct: 535 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT-PLHVAAKYGKVRVAELLLERDA 593

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
             +   K   TPL +A    NL +++ L+  G +P     +G+   HIA+++    + + 
Sbjct: 594 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 653

Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
           LL    G+   ES    TPLH AA  GH E V +LL + Q   +  +  G+T L    Q 
Sbjct: 654 LLQY-GGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQE 711

Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRA-TSTH 274
           GH+ VA +L+ +HG  + A   +G   LH A+  G  + ++FL+       DV A T   
Sbjct: 712 GHVPVADVLI-KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH---QADVNAKTKLG 767

Query: 275 LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLA 314
            + LH AA++GHT  +  LL  GA  N       + L +A
Sbjct: 768 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807



 Score =  117 bits (292), Expect = 2e-26
 Identities = 108/358 (30%), Positives = 156/358 (43%), Gaps = 49/358 (13%)

Query: 17  GRLRALKEELQAAGGCPGPAG---DTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKR 73
           G L  +K  LQ  G  P  +    +T LH AAR GH +V  YL +     + A  +D + 
Sbjct: 448 GHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK-VNAKAKDDQT 505

Query: 74  PLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLK 133
           PLH AA +GH + V+ LL   A  +    A  TPL +A    ++  +  L+E  A+    
Sbjct: 506 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 565

Query: 134 NKDGWNSFHIASREGDPLILQYLLT--VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLL 191
            K G+   H+A++ G   + + LL     P A     K   TPLH A  H +L+ VK+LL
Sbjct: 566 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNA---AGKNGLTPLHVAVHHNNLDIVKLLL 622

Query: 192 KR--CQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVT 249
            R    + P +    G T L  A +   ++VAR LL ++G   +AE   G   LH AA  
Sbjct: 623 PRGGSPHSPAWN---GYTPLHIAAKQNQVEVARSLL-QYGGSANAESVQGVTPLHLAAQE 678

Query: 250 GQDEAIRFLVSEL--------------------------------GVDVDVRATSTHLTA 277
           G  E +  L+S+                                 GV VD   T    T 
Sbjct: 679 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTP 737

Query: 278 LHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSE 335
           LH A+  G+   ++ LL   AD+N+K +   S LH A    H      LL++G   +E
Sbjct: 738 LHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 795



 Score =  115 bits (287), Expect = 8e-26
 Identities = 95/324 (29%), Positives = 151/324 (46%), Gaps = 37/324 (11%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G+T LH AA  G  +V+  L   +G ++ A ++    PL+ AA   H + V++LL  GA 
Sbjct: 111 GNTALHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 169

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGA---------------------------- 128
            +   +  +TPL +A  + +  V+  L+ +G                             
Sbjct: 170 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 229

Query: 129 -NPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAV 187
            NP + +K G+   HIA+   +  + Q LL        T      TPLH A+  G++  V
Sbjct: 230 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN-GITPLHIASRRGNVIMV 288

Query: 188 KVLLKR-CQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRA 246
           ++LL R  Q E   +D   +T L  A + GH+ ++ +LLD HGA + A+   G   +H A
Sbjct: 289 RLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILLD-HGAPIQAKTKNGLSPIHMA 345

Query: 247 AVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEK 306
           A     + +R L+ +   ++D   T  HLT LH AA  GH    + LL  GA  NS+   
Sbjct: 346 AQGDHLDCVRLLL-QYDAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 403

Query: 307 NRSALHLACAGQHLACAKFLLQSG 330
             + LH+AC   H+   + LL++G
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTG 427



 Score =  114 bits (285), Expect = 1e-25
 Identities = 98/305 (32%), Positives = 148/305 (48%), Gaps = 12/305 (3%)

Query: 31  GCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYL 90
           G  G      LH AAR+      A L +    + +  ++    PLH AA   + +  + L
Sbjct: 200 GTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNVAQLL 258

Query: 91  LGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDP 150
           L RGA+V+   +   TPL +A  R N+ +++ L++ GA    K KD     H A+R G  
Sbjct: 259 LNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHV 318

Query: 151 LILQYLLTV-CPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNC--GVT 207
            I + LL    P   KT++ +  +P+H AA   HL+ V++LL   QY+ +  D     +T
Sbjct: 319 RISEILLDHGAPIQAKTKNGL--SPIHMAAQGDHLDCVRLLL---QYDAEIDDITLDHLT 373

Query: 208 ALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVD 267
            L  A  CGH  VA++LLD+ GA  ++    G   LH A        +  L+ + G  +D
Sbjct: 374 PLHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACKKNHVRVMELLL-KTGASID 431

Query: 268 VRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLL 327
              T + LT LH A+  GH   ++ LL  GA  N  + K  + LH+A    H   AK+LL
Sbjct: 432 A-VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 490

Query: 328 QSGLK 332
           Q+  K
Sbjct: 491 QNKAK 495



 Score = 65.5 bits (158), Expect = 7e-11
 Identities = 70/239 (29%), Positives = 107/239 (44%), Gaps = 10/239 (4%)

Query: 93  RGAAVDCLKKADW-TPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPL 151
           R  + D  KKAD  T  + A    NL    + + +G +    N++G N  H+AS+EG   
Sbjct: 33  RNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVK 92

Query: 152 ILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMD 211
           ++  LL       +T +K   T LH AA+ G  E V+ L+       + +   G T L  
Sbjct: 93  MVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYM 150

Query: 212 AIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRAT 271
           A Q  H++V + LL E+GA  +     G   L  A   G +  +  L++  G    VR  
Sbjct: 151 AAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-YGTKGKVR-- 206

Query: 272 STHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
              L ALH AA+   T T   LL    + +   +   + LH+A   ++L  A+ LL  G
Sbjct: 207 ---LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 262



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 52/179 (29%), Positives = 82/179 (45%), Gaps = 6/179 (3%)

Query: 15  QEGRLRALKEELQAAGGCPGPA--GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYK 72
           ++ ++   +  LQ  G     +  G T LH AA+ GH +++A L           N+   
Sbjct: 644 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG-NLGNKSGL 702

Query: 73  RPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLL 132
            PLH  A  GH      L+  G  VD   +  +TPL +A    N+ +++ L++H A+   
Sbjct: 703 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 762

Query: 133 KNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTE-SKIRRTPLHTAAMHGHLEAVKVL 190
           K K G++  H A+++G   I+  LL    GA   E S    TPL  A   G++    VL
Sbjct: 763 KTKLGYSPLHQAAQQGHTDIVTLLLK--NGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  132 bits (331), Expect = 6e-31
 Identities = 95/298 (31%), Positives = 150/298 (50%), Gaps = 11/298 (3%)

Query: 41  LHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCL 100
           LH A++ GH  ++  L     + +E T +     LH AA  G  + VR L+  GA V+  
Sbjct: 49  LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107

Query: 101 KKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVC 160
            +  +TPL MA    +L V++ L+E+GAN  +  +DG+    +A ++G   ++ +L+   
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-- 165

Query: 161 PGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDV 220
              + T+ K+R   LH AA +       VLL+     PD     G T L  A    +++V
Sbjct: 166 ---YGTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNV 221

Query: 221 ARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHY 280
           A+LLL+  GA ++     G   LH A+  G    +R L+ + G  ++ + T   LT LH 
Sbjct: 222 AQLLLN-RGASVNFTPQNGITPLHIASRRGNVIMVRLLL-DRGAQIETK-TKDELTPLHC 278

Query: 281 AAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDIT 338
           AA+ GH    + LL  GA I +K +   S +H+A  G HL C + LLQ    + +DIT
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD-AEIDDIT 335



 Score =  121 bits (303), Expect = 1e-27
 Identities = 98/298 (32%), Positives = 143/298 (47%), Gaps = 10/298 (3%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +G T LH A+  GH  ++  L +  G     +N   + PLH AA  GH +  +YLL   A
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGD-PLILQ 154
            V+   K D TPL  A    +  +++ L+E+ ANP L    G    HIA+REG    +L 
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521

Query: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
            L      A  T+     TPLH AA +G +   ++LL+R    P+     G+T L  A+ 
Sbjct: 522 LLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHVAVH 578

Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
             ++D+ +LLL   G+  S   + G   LH AA   Q E  R L+   G      A S  
Sbjct: 579 HNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGG---SANAESVQ 634

Query: 275 -LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGL 331
            +T LH AA+EGH   +  LLS  A+ N  ++   + LHL     H+  A  L++ G+
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692



 Score =  120 bits (302), Expect = 1e-27
 Identities = 98/291 (33%), Positives = 148/291 (50%), Gaps = 8/291 (2%)

Query: 39  TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
           T LHCAAR+GH  +   L +  G  I+A  ++   P+H AA   H DCVR LL   A +D
Sbjct: 274 TPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 99  CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL- 157
            +     TPL +A    +  V + L++ GA P  +  +G+   HIA ++    +++ LL 
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392

Query: 158 TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
           T       TES +  TPLH A+  GHL  VK LL+R    P+  +    T L  A + GH
Sbjct: 393 TGASIDAVTESGL--TPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGH 449

Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
            +VA+ LL ++ A ++A+       LH AA  G    ++ L+ E   + ++  T+ H T 
Sbjct: 450 TEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGH-TP 506

Query: 278 LHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQ 328
           LH AA+EGH  T+  LL   A      +K  + LH+A     +  A+ LL+
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557



 Score =  120 bits (300), Expect = 2e-27
 Identities = 92/280 (32%), Positives = 133/280 (47%), Gaps = 8/280 (2%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           AG T LH AAR GH + +  L E        T + +  PLH AA  G       LL R A
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT-PLHVAAKYGKVRVAELLLERDA 560

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
             +   K   TPL +A    NL +++ L+  G +P     +G+   HIA+++    + + 
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620

Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
           LL    G+   ES    TPLH AA  GH E V +LL + Q   +  +  G+T L    Q 
Sbjct: 621 LLQY-GGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQE 678

Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRA-TSTH 274
           GH+ VA +L+ +HG  + A   +G   LH A+  G  + ++FL+       DV A T   
Sbjct: 679 GHVPVADVLI-KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH---QADVNAKTKLG 734

Query: 275 LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLA 314
            + LH AA++GHT  +  LL  GA  N       + L +A
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score =  117 bits (292), Expect = 2e-26
 Identities = 108/358 (30%), Positives = 156/358 (43%), Gaps = 49/358 (13%)

Query: 17  GRLRALKEELQAAGGCPGPAG---DTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKR 73
           G L  +K  LQ  G  P  +    +T LH AAR GH +V  YL +     + A  +D + 
Sbjct: 415 GHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK-VNAKAKDDQT 472

Query: 74  PLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLK 133
           PLH AA +GH + V+ LL   A  +    A  TPL +A    ++  +  L+E  A+    
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532

Query: 134 NKDGWNSFHIASREGDPLILQYLLT--VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLL 191
            K G+   H+A++ G   + + LL     P A     K   TPLH A  H +L+ VK+LL
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNA---AGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 192 KR--CQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVT 249
            R    + P +    G T L  A +   ++VAR LL ++G   +AE   G   LH AA  
Sbjct: 590 PRGGSPHSPAWN---GYTPLHIAAKQNQVEVARSLL-QYGGSANAESVQGVTPLHLAAQE 645

Query: 250 GQDEAIRFLVSEL--------------------------------GVDVDVRATSTHLTA 277
           G  E +  L+S+                                 GV VD   T    T 
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTP 704

Query: 278 LHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSE 335
           LH A+  G+   ++ LL   AD+N+K +   S LH A    H      LL++G   +E
Sbjct: 705 LHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762



 Score =  115 bits (287), Expect = 8e-26
 Identities = 95/324 (29%), Positives = 151/324 (46%), Gaps = 37/324 (11%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G+T LH AA  G  +V+  L   +G ++ A ++    PL+ AA   H + V++LL  GA 
Sbjct: 78  GNTALHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGA---------------------------- 128
            +   +  +TPL +A  + +  V+  L+ +G                             
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196

Query: 129 -NPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAV 187
            NP + +K G+   HIA+   +  + Q LL        T      TPLH A+  G++  V
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN-GITPLHIASRRGNVIMV 255

Query: 188 KVLLKR-CQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRA 246
           ++LL R  Q E   +D   +T L  A + GH+ ++ +LLD HGA + A+   G   +H A
Sbjct: 256 RLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILLD-HGAPIQAKTKNGLSPIHMA 312

Query: 247 AVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEK 306
           A     + +R L+ +   ++D   T  HLT LH AA  GH    + LL  GA  NS+   
Sbjct: 313 AQGDHLDCVRLLL-QYDAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 307 NRSALHLACAGQHLACAKFLLQSG 330
             + LH+AC   H+   + LL++G
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTG 394



 Score =  114 bits (285), Expect = 1e-25
 Identities = 98/305 (32%), Positives = 148/305 (48%), Gaps = 12/305 (3%)

Query: 31  GCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYL 90
           G  G      LH AAR+      A L +    + +  ++    PLH AA   + +  + L
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNVAQLL 225

Query: 91  LGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDP 150
           L RGA+V+   +   TPL +A  R N+ +++ L++ GA    K KD     H A+R G  
Sbjct: 226 LNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHV 285

Query: 151 LILQYLLTV-CPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNC--GVT 207
            I + LL    P   KT++ +  +P+H AA   HL+ V++LL   QY+ +  D     +T
Sbjct: 286 RISEILLDHGAPIQAKTKNGL--SPIHMAAQGDHLDCVRLLL---QYDAEIDDITLDHLT 340

Query: 208 ALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVD 267
            L  A  CGH  VA++LLD+ GA  ++    G   LH A        +  L+ + G  +D
Sbjct: 341 PLHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACKKNHVRVMELLL-KTGASID 398

Query: 268 VRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLL 327
              T + LT LH A+  GH   ++ LL  GA  N  + K  + LH+A    H   AK+LL
Sbjct: 399 A-VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457

Query: 328 QSGLK 332
           Q+  K
Sbjct: 458 QNKAK 462



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 52/179 (29%), Positives = 82/179 (45%), Gaps = 6/179 (3%)

Query: 15  QEGRLRALKEELQAAGGCPGPA--GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYK 72
           ++ ++   +  LQ  G     +  G T LH AA+ GH +++A L           N+   
Sbjct: 611 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG-NLGNKSGL 669

Query: 73  RPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLL 132
            PLH  A  GH      L+  G  VD   +  +TPL +A    N+ +++ L++H A+   
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729

Query: 133 KNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTE-SKIRRTPLHTAAMHGHLEAVKVL 190
           K K G++  H A+++G   I+  LL    GA   E S    TPL  A   G++    VL
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLK--NGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 62.4 bits (150), Expect = 6e-10
 Identities = 64/225 (28%), Positives = 100/225 (44%), Gaps = 9/225 (4%)

Query: 106 TPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWK 165
           T  + A    NL    + + +G +    N++G N  H+AS+EG   ++  LL       +
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILE 72

Query: 166 TESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLL 225
           T +K   T LH AA+ G  E V+ L+       + +   G T L  A Q  H++V + LL
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131

Query: 226 DEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEG 285
            E+GA  +     G   L  A   G +  +  L++  G    VR     L ALH AA+  
Sbjct: 132 -ENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-YGTKGKVR-----LPALHIAARND 184

Query: 286 HTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
            T T   LL    + +   +   + LH+A   ++L  A+ LL  G
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  132 bits (331), Expect = 6e-31
 Identities = 95/298 (31%), Positives = 150/298 (50%), Gaps = 11/298 (3%)

Query: 41  LHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCL 100
           LH A++ GH  ++  L     + +E T +     LH AA  G  + VR L+  GA V+  
Sbjct: 49  LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107

Query: 101 KKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVC 160
            +  +TPL MA    +L V++ L+E+GAN  +  +DG+    +A ++G   ++ +L+   
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-- 165

Query: 161 PGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDV 220
              + T+ K+R   LH AA +       VLL+     PD     G T L  A    +++V
Sbjct: 166 ---YGTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNV 221

Query: 221 ARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHY 280
           A+LLL+  GA ++     G   LH A+  G    +R L+ + G  ++ + T   LT LH 
Sbjct: 222 AQLLLN-RGASVNFTPQNGITPLHIASRRGNVIMVRLLL-DRGAQIETK-TKDELTPLHC 278

Query: 281 AAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDIT 338
           AA+ GH    + LL  GA I +K +   S +H+A  G HL C + LLQ    + +DIT
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD-AEIDDIT 335



 Score =  121 bits (303), Expect = 1e-27
 Identities = 98/298 (32%), Positives = 143/298 (47%), Gaps = 10/298 (3%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +G T LH A+  GH  ++  L +  G     +N   + PLH AA  GH +  +YLL   A
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGD-PLILQ 154
            V+   K D TPL  A    +  +++ L+E+ ANP L    G    HIA+REG    +L 
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521

Query: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
            L      A  T+     TPLH AA +G +   ++LL+R    P+     G+T L  A+ 
Sbjct: 522 LLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHVAVH 578

Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
             ++D+ +LLL   G+  S   + G   LH AA   Q E  R L+   G      A S  
Sbjct: 579 HNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGG---SANAESVQ 634

Query: 275 -LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGL 331
            +T LH AA+EGH   +  LLS  A+ N  ++   + LHL     H+  A  L++ G+
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692



 Score =  120 bits (302), Expect = 1e-27
 Identities = 98/291 (33%), Positives = 148/291 (50%), Gaps = 8/291 (2%)

Query: 39  TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
           T LHCAAR+GH  +   L +  G  I+A  ++   P+H AA   H DCVR LL   A +D
Sbjct: 274 TPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 99  CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL- 157
            +     TPL +A    +  V + L++ GA P  +  +G+   HIA ++    +++ LL 
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392

Query: 158 TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
           T       TES +  TPLH A+  GHL  VK LL+R    P+  +    T L  A + GH
Sbjct: 393 TGASIDAVTESGL--TPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGH 449

Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
            +VA+ LL ++ A ++A+       LH AA  G    ++ L+ E   + ++  T+ H T 
Sbjct: 450 TEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGH-TP 506

Query: 278 LHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQ 328
           LH AA+EGH  T+  LL   A      +K  + LH+A     +  A+ LL+
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557



 Score =  120 bits (300), Expect = 2e-27
 Identities = 92/280 (32%), Positives = 133/280 (47%), Gaps = 8/280 (2%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           AG T LH AAR GH + +  L E        T + +  PLH AA  G       LL R A
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT-PLHVAAKYGKVRVAELLLERDA 560

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
             +   K   TPL +A    NL +++ L+  G +P     +G+   HIA+++    + + 
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620

Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
           LL    G+   ES    TPLH AA  GH E V +LL + Q   +  +  G+T L    Q 
Sbjct: 621 LLQY-GGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQE 678

Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRA-TSTH 274
           GH+ VA +L+ +HG  + A   +G   LH A+  G  + ++FL+       DV A T   
Sbjct: 679 GHVPVADVLI-KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH---QADVNAKTKLG 734

Query: 275 LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLA 314
            + LH AA++GHT  +  LL  GA  N       + L +A
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score =  117 bits (292), Expect = 2e-26
 Identities = 108/358 (30%), Positives = 156/358 (43%), Gaps = 49/358 (13%)

Query: 17  GRLRALKEELQAAGGCPGPAG---DTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKR 73
           G L  +K  LQ  G  P  +    +T LH AAR GH +V  YL +     + A  +D + 
Sbjct: 415 GHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK-VNAKAKDDQT 472

Query: 74  PLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLK 133
           PLH AA +GH + V+ LL   A  +    A  TPL +A    ++  +  L+E  A+    
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532

Query: 134 NKDGWNSFHIASREGDPLILQYLLT--VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLL 191
            K G+   H+A++ G   + + LL     P A     K   TPLH A  H +L+ VK+LL
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNA---AGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 192 KR--CQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVT 249
            R    + P +    G T L  A +   ++VAR LL ++G   +AE   G   LH AA  
Sbjct: 590 PRGGSPHSPAWN---GYTPLHIAAKQNQVEVARSLL-QYGGSANAESVQGVTPLHLAAQE 645

Query: 250 GQDEAIRFLVSEL--------------------------------GVDVDVRATSTHLTA 277
           G  E +  L+S+                                 GV VD   T    T 
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTP 704

Query: 278 LHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSE 335
           LH A+  G+   ++ LL   AD+N+K +   S LH A    H      LL++G   +E
Sbjct: 705 LHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762



 Score =  115 bits (287), Expect = 8e-26
 Identities = 95/324 (29%), Positives = 151/324 (46%), Gaps = 37/324 (11%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G+T LH AA  G  +V+  L   +G ++ A ++    PL+ AA   H + V++LL  GA 
Sbjct: 78  GNTALHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGA---------------------------- 128
            +   +  +TPL +A  + +  V+  L+ +G                             
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196

Query: 129 -NPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAV 187
            NP + +K G+   HIA+   +  + Q LL        T      TPLH A+  G++  V
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN-GITPLHIASRRGNVIMV 255

Query: 188 KVLLKR-CQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRA 246
           ++LL R  Q E   +D   +T L  A + GH+ ++ +LLD HGA + A+   G   +H A
Sbjct: 256 RLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILLD-HGAPIQAKTKNGLSPIHMA 312

Query: 247 AVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEK 306
           A     + +R L+ +   ++D   T  HLT LH AA  GH    + LL  GA  NS+   
Sbjct: 313 AQGDHLDCVRLLL-QYDAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 307 NRSALHLACAGQHLACAKFLLQSG 330
             + LH+AC   H+   + LL++G
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTG 394



 Score =  114 bits (285), Expect = 1e-25
 Identities = 98/305 (32%), Positives = 148/305 (48%), Gaps = 12/305 (3%)

Query: 31  GCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYL 90
           G  G      LH AAR+      A L +    + +  ++    PLH AA   + +  + L
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNVAQLL 225

Query: 91  LGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDP 150
           L RGA+V+   +   TPL +A  R N+ +++ L++ GA    K KD     H A+R G  
Sbjct: 226 LNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHV 285

Query: 151 LILQYLLTV-CPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNC--GVT 207
            I + LL    P   KT++ +  +P+H AA   HL+ V++LL   QY+ +  D     +T
Sbjct: 286 RISEILLDHGAPIQAKTKNGL--SPIHMAAQGDHLDCVRLLL---QYDAEIDDITLDHLT 340

Query: 208 ALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVD 267
            L  A  CGH  VA++LLD+ GA  ++    G   LH A        +  L+ + G  +D
Sbjct: 341 PLHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACKKNHVRVMELLL-KTGASID 398

Query: 268 VRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLL 327
              T + LT LH A+  GH   ++ LL  GA  N  + K  + LH+A    H   AK+LL
Sbjct: 399 A-VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457

Query: 328 QSGLK 332
           Q+  K
Sbjct: 458 QNKAK 462



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 52/179 (29%), Positives = 82/179 (45%), Gaps = 6/179 (3%)

Query: 15  QEGRLRALKEELQAAGGCPGPA--GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYK 72
           ++ ++   +  LQ  G     +  G T LH AA+ GH +++A L           N+   
Sbjct: 611 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG-NLGNKSGL 669

Query: 73  RPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLL 132
            PLH  A  GH      L+  G  VD   +  +TPL +A    N+ +++ L++H A+   
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729

Query: 133 KNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTE-SKIRRTPLHTAAMHGHLEAVKVL 190
           K K G++  H A+++G   I+  LL    GA   E S    TPL  A   G++    VL
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLK--NGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 62.4 bits (150), Expect = 6e-10
 Identities = 64/225 (28%), Positives = 100/225 (44%), Gaps = 9/225 (4%)

Query: 106 TPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWK 165
           T  + A    NL    + + +G +    N++G N  H+AS+EG   ++  LL       +
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILE 72

Query: 166 TESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLL 225
           T +K   T LH AA+ G  E V+ L+       + +   G T L  A Q  H++V + LL
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131

Query: 226 DEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEG 285
            E+GA  +     G   L  A   G +  +  L++  G    VR     L ALH AA+  
Sbjct: 132 -ENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-YGTKGKVR-----LPALHIAARND 184

Query: 286 HTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
            T T   LL    + +   +   + LH+A   ++L  A+ LL  G
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  132 bits (331), Expect = 6e-31
 Identities = 95/298 (31%), Positives = 150/298 (50%), Gaps = 11/298 (3%)

Query: 41  LHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCL 100
           LH A++ GH  ++  L     + +E T +     LH AA  G  + VR L+  GA V+  
Sbjct: 49  LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107

Query: 101 KKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVC 160
            +  +TPL MA    +L V++ L+E+GAN  +  +DG+    +A ++G   ++ +L+   
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-- 165

Query: 161 PGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDV 220
              + T+ K+R   LH AA +       VLL+     PD     G T L  A    +++V
Sbjct: 166 ---YGTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNV 221

Query: 221 ARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHY 280
           A+LLL+  GA ++     G   LH A+  G    +R L+ + G  ++ + T   LT LH 
Sbjct: 222 AQLLLN-RGASVNFTPQNGITPLHIASRRGNVIMVRLLL-DRGAQIETK-TKDELTPLHC 278

Query: 281 AAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDIT 338
           AA+ GH    + LL  GA I +K +   S +H+A  G HL C + LLQ    + +DIT
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD-AEIDDIT 335



 Score =  121 bits (303), Expect = 1e-27
 Identities = 98/298 (32%), Positives = 143/298 (47%), Gaps = 10/298 (3%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +G T LH A+  GH  ++  L +  G     +N   + PLH AA  GH +  +YLL   A
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGD-PLILQ 154
            V+   K D TPL  A    +  +++ L+E+ ANP L    G    HIA+REG    +L 
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521

Query: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
            L      A  T+     TPLH AA +G +   ++LL+R    P+     G+T L  A+ 
Sbjct: 522 LLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHVAVH 578

Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
             ++D+ +LLL   G+  S   + G   LH AA   Q E  R L+   G      A S  
Sbjct: 579 HNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGG---SANAESVQ 634

Query: 275 -LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGL 331
            +T LH AA+EGH   +  LLS  A+ N  ++   + LHL     H+  A  L++ G+
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692



 Score =  120 bits (302), Expect = 1e-27
 Identities = 98/291 (33%), Positives = 148/291 (50%), Gaps = 8/291 (2%)

Query: 39  TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
           T LHCAAR+GH  +   L +  G  I+A  ++   P+H AA   H DCVR LL   A +D
Sbjct: 274 TPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 99  CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL- 157
            +     TPL +A    +  V + L++ GA P  +  +G+   HIA ++    +++ LL 
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392

Query: 158 TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
           T       TES +  TPLH A+  GHL  VK LL+R    P+  +    T L  A + GH
Sbjct: 393 TGASIDAVTESGL--TPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGH 449

Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
            +VA+ LL ++ A ++A+       LH AA  G    ++ L+ E   + ++  T+ H T 
Sbjct: 450 TEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGH-TP 506

Query: 278 LHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQ 328
           LH AA+EGH  T+  LL   A      +K  + LH+A     +  A+ LL+
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557



 Score =  120 bits (300), Expect = 2e-27
 Identities = 92/280 (32%), Positives = 133/280 (47%), Gaps = 8/280 (2%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           AG T LH AAR GH + +  L E        T + +  PLH AA  G       LL R A
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT-PLHVAAKYGKVRVAELLLERDA 560

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
             +   K   TPL +A    NL +++ L+  G +P     +G+   HIA+++    + + 
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620

Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
           LL    G+   ES    TPLH AA  GH E V +LL + Q   +  +  G+T L    Q 
Sbjct: 621 LLQY-GGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQE 678

Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRA-TSTH 274
           GH+ VA +L+ +HG  + A   +G   LH A+  G  + ++FL+       DV A T   
Sbjct: 679 GHVPVADVLI-KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH---QADVNAKTKLG 734

Query: 275 LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLA 314
            + LH AA++GHT  +  LL  GA  N       + L +A
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score =  117 bits (292), Expect = 2e-26
 Identities = 108/358 (30%), Positives = 156/358 (43%), Gaps = 49/358 (13%)

Query: 17  GRLRALKEELQAAGGCPGPAG---DTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKR 73
           G L  +K  LQ  G  P  +    +T LH AAR GH +V  YL +     + A  +D + 
Sbjct: 415 GHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK-VNAKAKDDQT 472

Query: 74  PLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLK 133
           PLH AA +GH + V+ LL   A  +    A  TPL +A    ++  +  L+E  A+    
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532

Query: 134 NKDGWNSFHIASREGDPLILQYLLT--VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLL 191
            K G+   H+A++ G   + + LL     P A     K   TPLH A  H +L+ VK+LL
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNA---AGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 192 KR--CQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVT 249
            R    + P +    G T L  A +   ++VAR LL ++G   +AE   G   LH AA  
Sbjct: 590 PRGGSPHSPAWN---GYTPLHIAAKQNQVEVARSLL-QYGGSANAESVQGVTPLHLAAQE 645

Query: 250 GQDEAIRFLVSEL--------------------------------GVDVDVRATSTHLTA 277
           G  E +  L+S+                                 GV VD   T    T 
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTP 704

Query: 278 LHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSE 335
           LH A+  G+   ++ LL   AD+N+K +   S LH A    H      LL++G   +E
Sbjct: 705 LHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762



 Score =  115 bits (287), Expect = 8e-26
 Identities = 95/324 (29%), Positives = 151/324 (46%), Gaps = 37/324 (11%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G+T LH AA  G  +V+  L   +G ++ A ++    PL+ AA   H + V++LL  GA 
Sbjct: 78  GNTALHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGA---------------------------- 128
            +   +  +TPL +A  + +  V+  L+ +G                             
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196

Query: 129 -NPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAV 187
            NP + +K G+   HIA+   +  + Q LL        T      TPLH A+  G++  V
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN-GITPLHIASRRGNVIMV 255

Query: 188 KVLLKR-CQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRA 246
           ++LL R  Q E   +D   +T L  A + GH+ ++ +LLD HGA + A+   G   +H A
Sbjct: 256 RLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILLD-HGAPIQAKTKNGLSPIHMA 312

Query: 247 AVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEK 306
           A     + +R L+ +   ++D   T  HLT LH AA  GH    + LL  GA  NS+   
Sbjct: 313 AQGDHLDCVRLLL-QYDAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 307 NRSALHLACAGQHLACAKFLLQSG 330
             + LH+AC   H+   + LL++G
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTG 394



 Score =  114 bits (285), Expect = 1e-25
 Identities = 98/305 (32%), Positives = 148/305 (48%), Gaps = 12/305 (3%)

Query: 31  GCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYL 90
           G  G      LH AAR+      A L +    + +  ++    PLH AA   + +  + L
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNVAQLL 225

Query: 91  LGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDP 150
           L RGA+V+   +   TPL +A  R N+ +++ L++ GA    K KD     H A+R G  
Sbjct: 226 LNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHV 285

Query: 151 LILQYLLTV-CPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNC--GVT 207
            I + LL    P   KT++ +  +P+H AA   HL+ V++LL   QY+ +  D     +T
Sbjct: 286 RISEILLDHGAPIQAKTKNGL--SPIHMAAQGDHLDCVRLLL---QYDAEIDDITLDHLT 340

Query: 208 ALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVD 267
            L  A  CGH  VA++LLD+ GA  ++    G   LH A        +  L+ + G  +D
Sbjct: 341 PLHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACKKNHVRVMELLL-KTGASID 398

Query: 268 VRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLL 327
              T + LT LH A+  GH   ++ LL  GA  N  + K  + LH+A    H   AK+LL
Sbjct: 399 A-VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457

Query: 328 QSGLK 332
           Q+  K
Sbjct: 458 QNKAK 462



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 52/179 (29%), Positives = 82/179 (45%), Gaps = 6/179 (3%)

Query: 15  QEGRLRALKEELQAAGGCPGPA--GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYK 72
           ++ ++   +  LQ  G     +  G T LH AA+ GH +++A L           N+   
Sbjct: 611 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG-NLGNKSGL 669

Query: 73  RPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLL 132
            PLH  A  GH      L+  G  VD   +  +TPL +A    N+ +++ L++H A+   
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729

Query: 133 KNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTE-SKIRRTPLHTAAMHGHLEAVKVL 190
           K K G++  H A+++G   I+  LL    GA   E S    TPL  A   G++    VL
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLK--NGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 62.4 bits (150), Expect = 6e-10
 Identities = 64/225 (28%), Positives = 100/225 (44%), Gaps = 9/225 (4%)

Query: 106 TPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWK 165
           T  + A    NL    + + +G +    N++G N  H+AS+EG   ++  LL       +
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILE 72

Query: 166 TESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLL 225
           T +K   T LH AA+ G  E V+ L+       + +   G T L  A Q  H++V + LL
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131

Query: 226 DEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEG 285
            E+GA  +     G   L  A   G +  +  L++  G    VR     L ALH AA+  
Sbjct: 132 -ENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-YGTKGKVR-----LPALHIAARND 184

Query: 286 HTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
            T T   LL    + +   +   + LH+A   ++L  A+ LL  G
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  132 bits (331), Expect = 6e-31
 Identities = 95/298 (31%), Positives = 150/298 (50%), Gaps = 11/298 (3%)

Query: 41  LHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCL 100
           LH A++ GH  ++  L     + +E T +     LH AA  G  + VR L+  GA V+  
Sbjct: 49  LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107

Query: 101 KKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVC 160
            +  +TPL MA    +L V++ L+E+GAN  +  +DG+    +A ++G   ++ +L+   
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-- 165

Query: 161 PGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDV 220
              + T+ K+R   LH AA +       VLL+     PD     G T L  A    +++V
Sbjct: 166 ---YGTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNV 221

Query: 221 ARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHY 280
           A+LLL+  GA ++     G   LH A+  G    +R L+ + G  ++ + T   LT LH 
Sbjct: 222 AQLLLN-RGASVNFTPQNGITPLHIASRRGNVIMVRLLL-DRGAQIETK-TKDELTPLHC 278

Query: 281 AAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDIT 338
           AA+ GH    + LL  GA I +K +   S +H+A  G HL C + LLQ    + +DIT
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD-AEIDDIT 335



 Score =  121 bits (303), Expect = 1e-27
 Identities = 98/298 (32%), Positives = 143/298 (47%), Gaps = 10/298 (3%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +G T LH A+  GH  ++  L +  G     +N   + PLH AA  GH +  +YLL   A
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGD-PLILQ 154
            V+   K D TPL  A    +  +++ L+E+ ANP L    G    HIA+REG    +L 
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521

Query: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
            L      A  T+     TPLH AA +G +   ++LL+R    P+     G+T L  A+ 
Sbjct: 522 LLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHVAVH 578

Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
             ++D+ +LLL   G+  S   + G   LH AA   Q E  R L+   G      A S  
Sbjct: 579 HNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGG---SANAESVQ 634

Query: 275 -LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGL 331
            +T LH AA+EGH   +  LLS  A+ N  ++   + LHL     H+  A  L++ G+
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692



 Score =  120 bits (302), Expect = 1e-27
 Identities = 98/291 (33%), Positives = 148/291 (50%), Gaps = 8/291 (2%)

Query: 39  TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
           T LHCAAR+GH  +   L +  G  I+A  ++   P+H AA   H DCVR LL   A +D
Sbjct: 274 TPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 99  CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL- 157
            +     TPL +A    +  V + L++ GA P  +  +G+   HIA ++    +++ LL 
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392

Query: 158 TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
           T       TES +  TPLH A+  GHL  VK LL+R    P+  +    T L  A + GH
Sbjct: 393 TGASIDAVTESGL--TPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGH 449

Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
            +VA+ LL ++ A ++A+       LH AA  G    ++ L+ E   + ++  T+ H T 
Sbjct: 450 TEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGH-TP 506

Query: 278 LHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQ 328
           LH AA+EGH  T+  LL   A      +K  + LH+A     +  A+ LL+
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557



 Score =  120 bits (300), Expect = 2e-27
 Identities = 92/280 (32%), Positives = 133/280 (47%), Gaps = 8/280 (2%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           AG T LH AAR GH + +  L E        T + +  PLH AA  G       LL R A
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT-PLHVAAKYGKVRVAELLLERDA 560

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
             +   K   TPL +A    NL +++ L+  G +P     +G+   HIA+++    + + 
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620

Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
           LL    G+   ES    TPLH AA  GH E V +LL + Q   +  +  G+T L    Q 
Sbjct: 621 LLQY-GGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQE 678

Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRA-TSTH 274
           GH+ VA +L+ +HG  + A   +G   LH A+  G  + ++FL+       DV A T   
Sbjct: 679 GHVPVADVLI-KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH---QADVNAKTKLG 734

Query: 275 LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLA 314
            + LH AA++GHT  +  LL  GA  N       + L +A
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score =  117 bits (292), Expect = 2e-26
 Identities = 108/358 (30%), Positives = 156/358 (43%), Gaps = 49/358 (13%)

Query: 17  GRLRALKEELQAAGGCPGPAG---DTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKR 73
           G L  +K  LQ  G  P  +    +T LH AAR GH +V  YL +     + A  +D + 
Sbjct: 415 GHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK-VNAKAKDDQT 472

Query: 74  PLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLK 133
           PLH AA +GH + V+ LL   A  +    A  TPL +A    ++  +  L+E  A+    
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532

Query: 134 NKDGWNSFHIASREGDPLILQYLLT--VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLL 191
            K G+   H+A++ G   + + LL     P A     K   TPLH A  H +L+ VK+LL
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNA---AGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 192 KR--CQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVT 249
            R    + P +    G T L  A +   ++VAR LL ++G   +AE   G   LH AA  
Sbjct: 590 PRGGSPHSPAWN---GYTPLHIAAKQNQVEVARSLL-QYGGSANAESVQGVTPLHLAAQE 645

Query: 250 GQDEAIRFLVSEL--------------------------------GVDVDVRATSTHLTA 277
           G  E +  L+S+                                 GV VD   T    T 
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTP 704

Query: 278 LHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSE 335
           LH A+  G+   ++ LL   AD+N+K +   S LH A    H      LL++G   +E
Sbjct: 705 LHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762



 Score =  115 bits (287), Expect = 8e-26
 Identities = 95/324 (29%), Positives = 151/324 (46%), Gaps = 37/324 (11%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G+T LH AA  G  +V+  L   +G ++ A ++    PL+ AA   H + V++LL  GA 
Sbjct: 78  GNTALHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGA---------------------------- 128
            +   +  +TPL +A  + +  V+  L+ +G                             
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196

Query: 129 -NPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAV 187
            NP + +K G+   HIA+   +  + Q LL        T      TPLH A+  G++  V
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN-GITPLHIASRRGNVIMV 255

Query: 188 KVLLKR-CQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRA 246
           ++LL R  Q E   +D   +T L  A + GH+ ++ +LLD HGA + A+   G   +H A
Sbjct: 256 RLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILLD-HGAPIQAKTKNGLSPIHMA 312

Query: 247 AVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEK 306
           A     + +R L+ +   ++D   T  HLT LH AA  GH    + LL  GA  NS+   
Sbjct: 313 AQGDHLDCVRLLL-QYDAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 307 NRSALHLACAGQHLACAKFLLQSG 330
             + LH+AC   H+   + LL++G
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTG 394



 Score =  114 bits (285), Expect = 1e-25
 Identities = 98/305 (32%), Positives = 148/305 (48%), Gaps = 12/305 (3%)

Query: 31  GCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYL 90
           G  G      LH AAR+      A L +    + +  ++    PLH AA   + +  + L
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNVAQLL 225

Query: 91  LGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDP 150
           L RGA+V+   +   TPL +A  R N+ +++ L++ GA    K KD     H A+R G  
Sbjct: 226 LNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHV 285

Query: 151 LILQYLLTV-CPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNC--GVT 207
            I + LL    P   KT++ +  +P+H AA   HL+ V++LL   QY+ +  D     +T
Sbjct: 286 RISEILLDHGAPIQAKTKNGL--SPIHMAAQGDHLDCVRLLL---QYDAEIDDITLDHLT 340

Query: 208 ALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVD 267
            L  A  CGH  VA++LLD+ GA  ++    G   LH A        +  L+ + G  +D
Sbjct: 341 PLHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACKKNHVRVMELLL-KTGASID 398

Query: 268 VRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLL 327
              T + LT LH A+  GH   ++ LL  GA  N  + K  + LH+A    H   AK+LL
Sbjct: 399 A-VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457

Query: 328 QSGLK 332
           Q+  K
Sbjct: 458 QNKAK 462



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 52/179 (29%), Positives = 82/179 (45%), Gaps = 6/179 (3%)

Query: 15  QEGRLRALKEELQAAGGCPGPA--GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYK 72
           ++ ++   +  LQ  G     +  G T LH AA+ GH +++A L           N+   
Sbjct: 611 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG-NLGNKSGL 669

Query: 73  RPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLL 132
            PLH  A  GH      L+  G  VD   +  +TPL +A    N+ +++ L++H A+   
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729

Query: 133 KNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTE-SKIRRTPLHTAAMHGHLEAVKVL 190
           K K G++  H A+++G   I+  LL    GA   E S    TPL  A   G++    VL
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLK--NGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 62.4 bits (150), Expect = 6e-10
 Identities = 64/225 (28%), Positives = 100/225 (44%), Gaps = 9/225 (4%)

Query: 106 TPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWK 165
           T  + A    NL    + + +G +    N++G N  H+AS+EG   ++  LL       +
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILE 72

Query: 166 TESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLL 225
           T +K   T LH AA+ G  E V+ L+       + +   G T L  A Q  H++V + LL
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131

Query: 226 DEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEG 285
            E+GA  +     G   L  A   G +  +  L++  G    VR     L ALH AA+  
Sbjct: 132 -ENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-YGTKGKVR-----LPALHIAARND 184

Query: 286 HTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
            T T   LL    + +   +   + LH+A   ++L  A+ LL  G
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  128 bits (322), Expect = 7e-30
 Identities = 95/295 (32%), Positives = 144/295 (48%), Gaps = 6/295 (2%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +G T +H AA  GH ++++ L    G     TN   +  LH AA  G  + VRYL+  GA
Sbjct: 432 SGLTPIHVAAFMGHVNIVSQLMHH-GASPNTTNVRGETALHMAARSGQAEVVRYLVQDGA 490

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
            V+   K D TPL ++       ++Q+L++ GA+P      G+   H+++REG   +  +
Sbjct: 491 QVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAF 550

Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
           LL     +    +K   TPLH AA +G LE   +LL++    PD     G+T L  A   
Sbjct: 551 LLD-HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK-SASPDAAGKSGLTPLHVAAHY 608

Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
            +  VA LLLD+ GA   A    G   LH AA   Q +    L+ E G D +   T   +
Sbjct: 609 DNQKVALLLLDQ-GASPHAAAKNGYTPLHIAAKKNQMDIATTLL-EYGADANA-VTRQGI 665

Query: 276 TALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
            ++H AA+EGH   +  LL   A++N  ++   + LHLA     +  A+ L+  G
Sbjct: 666 ASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG 720



 Score =  126 bits (316), Expect = 3e-29
 Identities = 93/303 (30%), Positives = 151/303 (49%), Gaps = 13/303 (4%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G   LH A++ GH +V++ L +    +++A  +     LH A+  G  + V+ L+  GA 
Sbjct: 74  GLNALHLASKEGHVEVVSELLQREA-NVDAATKKGNTALHIASLAGQAEVVKVLVTNGAN 132

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
           V+   +  +TPL MA    +L V++ L+++GA+  L  +DG+    +A ++G   ++  L
Sbjct: 133 VNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192

Query: 157 LTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCG 216
           L        T+ K+R   LH AA     +A  +LL+      D     G T L  A   G
Sbjct: 193 LEN-----DTKGKVRLPALHIAARKDDTKAAALLLQN-DNNADVESKSGFTPLHIAAHYG 246

Query: 217 HIDVARLLLDEHGAC-LSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
           +I+VA LLL+   A   +A + +    LH A+  G    ++ L+ + G  +D + T   L
Sbjct: 247 NINVATLLLNRAAAVDFTARNDI--TPLHVASKRGNANMVKLLL-DRGAKIDAK-TRDGL 302

Query: 276 TALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSE 335
           T LH  A+ GH   ++ LL   A I SK +   S LH+A  G HL C + LLQ  +   +
Sbjct: 303 TPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNV-PVD 361

Query: 336 DIT 338
           D+T
Sbjct: 362 DVT 364



 Score =  125 bits (314), Expect = 6e-29
 Identities = 94/299 (31%), Positives = 152/299 (50%), Gaps = 12/299 (4%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G+T LH AAR G  +V+ YL +  G  +EA  +D + PLH +A +G  D V+ LL +GA+
Sbjct: 466 GETALHMAARSGQAEVVRYLVQD-GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGAS 524

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
            +    + +TPL ++    +  V   L++HGA+  +  K G+   H+A++ G   +   L
Sbjct: 525 PNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLL 584

Query: 157 L--TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
           L  +  P A     K   TPLH AA H   + V +LL      P      G T L  A +
Sbjct: 585 LQKSASPDA---AGKSGLTPLHVAA-HYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAK 640

Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATS-T 273
              +D+A  LL E+GA  +A    G  ++H AA  G  + +  L   LG + +V  ++ +
Sbjct: 641 KNQMDIATTLL-EYGADANAVTRQGIASVHLAAQEGHVDMVSLL---LGRNANVNLSNKS 696

Query: 274 HLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLK 332
            LT LH AA+E   +  + L++ GA ++++ +   + LH+ C   ++    FLLQ   K
Sbjct: 697 GLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAK 755



 Score =  119 bits (297), Expect = 5e-27
 Identities = 97/318 (30%), Positives = 151/318 (47%), Gaps = 12/318 (3%)

Query: 41  LHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCL 100
           LH AAR       A L +    + +  ++    PLH AA  G+ +    LL R AAVD  
Sbjct: 206 LHIAARKDDTKAAALLLQN-DNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264

Query: 101 KKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL-TV 159
            + D TPL +A  R N  +++ L++ GA    K +DG    H  +R G   +++ LL   
Sbjct: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324

Query: 160 CPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHID 219
            P   KT++ +  +PLH A    HL  V++LL+      D   N  +TAL  A  CGH  
Sbjct: 325 APILSKTKNGL--SPLHMATQGDHLNCVQLLLQH-NVPVDDVTNDYLTALHVAAHCGHYK 381

Query: 220 VARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALH 279
           VA++LLD+  A  +A+   G   LH A    + + +  L+   G  +    T + LT +H
Sbjct: 382 VAKVLLDKK-ANPNAKALNGFTPLHIACKKNRIKVMELLLKH-GASIQA-VTESGLTPIH 438

Query: 280 YAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG----LKDSE 335
            AA  GH + +  L+  GA  N+ + +  +ALH+A         ++L+Q G     K  +
Sbjct: 439 VAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKD 498

Query: 336 DITGTLAQQLPRRADVLQ 353
           D T         +AD++Q
Sbjct: 499 DQTPLHISARLGKADIVQ 516



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 65/188 (34%), Positives = 88/188 (46%), Gaps = 3/188 (1%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G T LH AA+    D+   L E +G D  A  R     +H AA  GH D V  LLGR A 
Sbjct: 631 GYTPLHIAAKKNQMDIATTLLE-YGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNAN 689

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
           V+   K+  TPL +A     + V + LV  GA+   + K G+   H+    G+  I+ +L
Sbjct: 690 VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749

Query: 157 LTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCG 216
           L         ++K   TPLH AA  GH   + VLL+     P+     G TAL  A + G
Sbjct: 750 LQHSAKV-NAKTKNGYTPLHQAAQQGHTHIINVLLQN-NASPNELTVNGNTALGIARRLG 807

Query: 217 HIDVARLL 224
           +I V   L
Sbjct: 808 YISVVDTL 815



 Score = 31.2 bits (69), Expect = 1.5
 Identities = 17/48 (35%), Positives = 23/48 (47%)

Query: 281 AAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQ 328
           AA+ GH       +  G DIN  ++   +ALHLA    H+     LLQ
Sbjct: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQ 95


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  125 bits (315), Expect = 4e-29
 Identities = 101/295 (34%), Positives = 141/295 (47%), Gaps = 8/295 (2%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G T LH A     R V+  L  A  + + A + D    LH AA  G     R LL + A+
Sbjct: 471 GSTPLHMAVERRVRGVVELLL-ARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNAS 529

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
           V+ +     TP+ +AC      +++ L+  G +  L+ KD W   H A+ +G   I++ L
Sbjct: 530 VNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVK-L 588

Query: 157 LTVCPG-AWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
           L   PG +   ++   RTPLH AA  GH    ++L+  C  + +       T L  A + 
Sbjct: 589 LAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCS-DVNVCSLLAQTPLHVAAET 647

Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
           GH   ARLLL   GA   A  S G  ALH AA  G    ++ LV E   DV  R      
Sbjct: 648 GHTSTARLLL-HRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKA-DVLARGPLNQ- 704

Query: 276 TALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
           TALH AA  GH+  ++ L+S    I+  DE+  SALHLA  G+H    + LL+ G
Sbjct: 705 TALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHG 758



 Score =  111 bits (278), Expect = 9e-25
 Identities = 86/269 (31%), Positives = 128/269 (47%), Gaps = 8/269 (2%)

Query: 39  TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
           T LH AA++G       L E     +   + + + P+H A   G  + VR LL RG  V 
Sbjct: 506 TALHFAAQNGDESSTRLLLEK-NASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVS 564

Query: 99  CLKKADWTPLMMACTRKNLGVIQELVEH-GANPLLKNKDGWNSFHIASREGDPLILQYLL 157
              K  W PL  A  + +L +++ L +  G +   +  DG    H+A++ G   + + L+
Sbjct: 565 LQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILI 624

Query: 158 TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
            +C       S + +TPLH AA  GH    ++LL R   +     + G TAL  A + GH
Sbjct: 625 DLCSDV-NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD-GYTALHLAARNGH 682

Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
           +   +LL++E    L A   L   ALH AA  G  E +  LVS   +D+        L+A
Sbjct: 683 LATVKLLVEEKADVL-ARGPLNQTALHLAAAHGHSEVVEELVSADVIDL---FDEQGLSA 738

Query: 278 LHYAAKEGHTSTIQTLLSLGADINSKDEK 306
           LH AA+  H  T++TLL  GA IN +  K
Sbjct: 739 LHLAAQGRHAQTVETLLRHGAHINLQSLK 767



 Score =  109 bits (273), Expect = 3e-24
 Identities = 100/314 (31%), Positives = 143/314 (45%), Gaps = 13/314 (4%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +G +LLH A   G  +   +L      +   +NR    PLH A     R  V  LL R  
Sbjct: 437 SGASLLHLAVEAGQEECAKWLLLN-NANPNLSNRRGSTPLHMAVERRVRGVVELLLARKI 495

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
           +V+   +  WT L  A    +    + L+E  A+    + +G    H+A + G   I++ 
Sbjct: 496 SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRI 555

Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
           LL         + K    PLH AA  GHL  VK+L K+     + +   G T L  A Q 
Sbjct: 556 LLRRGVDV-SLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQR 614

Query: 216 GHIDVARLLLD---EHGACLSAEDSLGAQA-LHRAAVTGQDEAIRFLVSELGVDVDVRAT 271
           GH  VAR+L+D   +   C     SL AQ  LH AA TG     R L+   G   +   T
Sbjct: 615 GHYRVARILIDLCSDVNVC-----SLLAQTPLHVAAETGHTSTARLLLHR-GAGKEAM-T 667

Query: 272 STHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGL 331
           S   TALH AA+ GH +T++ L+   AD+ ++   N++ALHLA A  H    + L+ + +
Sbjct: 668 SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV 727

Query: 332 KDSEDITGTLAQQL 345
            D  D  G  A  L
Sbjct: 728 IDLFDEQGLSALHL 741



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 67/209 (32%), Positives = 93/209 (44%), Gaps = 5/209 (2%)

Query: 41  LHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCL 100
           LH AA  GH  ++  LA+  G+ + A   D + PLH AA  GH    R L+   + V+  
Sbjct: 574 LHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVC 633

Query: 101 KKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVC 160
                TPL +A    +    + L+  GA       DG+ + H+A+R G  L    LL   
Sbjct: 634 SLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGH-LATVKLLVEE 692

Query: 161 PGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDV 220
                    + +T LH AA HGH E V+ L+       D  D  G++AL  A Q  H   
Sbjct: 693 KADVLARGPLNQTALHLAAAHGHSEVVEELVSADVI--DLFDEQGLSALHLAAQGRHAQT 750

Query: 221 ARLLLDEHGACLSAEDSLGAQALHRAAVT 249
              LL  HGA ++ + SL  Q  H  A T
Sbjct: 751 VETLL-RHGAHINLQ-SLKFQGGHGPAAT 777



 Score = 37.7 bits (86), Expect = 0.016
 Identities = 24/65 (36%), Positives = 31/65 (47%), Gaps = 2/65 (3%)

Query: 34  GPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGR 93
           GP   T LH AA HGH +V+  L  A  +D+   +      LH AA   H   V  LL  
Sbjct: 700 GPLNQTALHLAAAHGHSEVVEELVSADVIDL--FDEQGLSALHLAAQGRHAQTVETLLRH 757

Query: 94  GAAVD 98
           GA ++
Sbjct: 758 GAHIN 762


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  123 bits (309), Expect = 2e-28
 Identities = 98/295 (33%), Positives = 145/295 (49%), Gaps = 6/295 (2%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +G T +H AA  GH +++  L +  G   + TN   +  LH AA  G  + VR LL  GA
Sbjct: 409 SGLTPIHVAAFMGHLNIVLLLLQN-GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 467

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
            VD   + + TPL +A       ++Q L++H A+P     +G+   HI++REG   +   
Sbjct: 468 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 527

Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
           LL     A    +K   TPLH AA +G L+  K+LL+R +   D     G+T L  A   
Sbjct: 528 LLE-AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR-RAAADSAGKNGLTPLHVAAHY 585

Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
            +  VA LLL E GA   A    G   LH AA   Q +    L++  G + ++  T   +
Sbjct: 586 DNQKVALLLL-EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN-YGAETNI-VTKQGV 642

Query: 276 TALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
           T LH A++EGHT  +  LL  GA+I+   +   ++LHLA     +  A  L + G
Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG 697



 Score =  118 bits (295), Expect = 9e-27
 Identities = 99/279 (35%), Positives = 135/279 (48%), Gaps = 8/279 (2%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G T LH +AR G  DV + L EA      AT + +  PLH AA  G  D  + LL R AA
Sbjct: 509 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFT-PLHVAAKYGSLDVAKLLLQRRAA 567

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
            D   K   TPL +A    N  V   L+E GA+P    K+G+   HIA+++    I   L
Sbjct: 568 ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 627

Query: 157 LTVCPGA-WKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
           L    GA     +K   TPLH A+  GH + V +LL +           G+T+L  A Q 
Sbjct: 628 LNY--GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-NIHMSTKSGLTSLHLAAQE 684

Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
             ++VA +L  +HGA   A   LG   L  A   G  + + FL+ + G +V+ + T    
Sbjct: 685 DKVNVADILT-KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ-GANVNAK-TKNGY 741

Query: 276 TALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLA 314
           T LH AA++GHT  I  LL  GA  N+      +AL +A
Sbjct: 742 TPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 780



 Score =  117 bits (292), Expect = 2e-26
 Identities = 100/323 (30%), Positives = 153/323 (47%), Gaps = 45/323 (13%)

Query: 44  AARHGHRD-VLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKK 102
           AAR G+ D V+ YL    G+DI   N++    LH AA  GH   V+ LLGRG++VD   K
Sbjct: 17  AARAGNLDKVVEYLKG--GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 74

Query: 103 ADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPG 162
              T L +A       V++ LV+ GAN   ++++G+   ++A++E    +++YLL    G
Sbjct: 75  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE--NG 132

Query: 163 A-WKTESKIRRTPLHTAAMHGHLEAVKVLLK----------------------------R 193
           A   T ++   TPL  A   GH +AV +LL+                            +
Sbjct: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 192

Query: 194 CQYEPDYRD--------NCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHR 245
             +  D +           G T L  A   G+++VA LLL+  GA +      G   LH 
Sbjct: 193 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN-RGAAVDFTARNGITPLHV 251

Query: 246 AAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDE 305
           A+  G    ++ L+ + G  +D + T   LT LH AA+ GH   ++ LL  GA + ++ +
Sbjct: 252 ASKRGNTNMVKLLL-DRGGQIDAK-TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 309

Query: 306 KNRSALHLACAGQHLACAKFLLQ 328
              S LH+A  G H+ C K LLQ
Sbjct: 310 NGLSPLHMAAQGDHVECVKHLLQ 332



 Score =  108 bits (271), Expect = 6e-24
 Identities = 87/270 (32%), Positives = 132/270 (48%), Gaps = 7/270 (2%)

Query: 62  MDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQ 121
           M +  T      PLH AA  G+ +    LL RGAAVD   +   TPL +A  R N  +++
Sbjct: 203 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 262

Query: 122 ELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTV-CPGAWKTESKIRRTPLHTAAM 180
            L++ G     K +DG    H A+R G   +++ LL    P   +T++ +  +PLH AA 
Sbjct: 263 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL--SPLHMAAQ 320

Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
             H+E VK LL+      D   +  +TAL  A  CGH  V +LLLD+  A  +A    G 
Sbjct: 321 GDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDKR-ANPNARALNGF 378

Query: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADI 300
             LH A    + + +  LV + G  +    T + LT +H AA  GH + +  LL  GA  
Sbjct: 379 TPLHIACKKNRIKVMELLV-KYGASIQA-ITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436

Query: 301 NSKDEKNRSALHLACAGQHLACAKFLLQSG 330
           +  + +  +ALH+A     +   + LL++G
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNG 466



 Score =  103 bits (257), Expect = 2e-22
 Identities = 90/294 (30%), Positives = 141/294 (47%), Gaps = 8/294 (2%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +G T LH AA +G+ +V   L    G  ++ T R+   PLH A+  G+ + V+ LL RG 
Sbjct: 211 SGFTPLHIAAHYGNVNVATLLLNR-GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 269

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
            +D   +   TPL  A    +  V++ L+E GA  L + K+G +  H+A++      +++
Sbjct: 270 QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 329

Query: 156 LLT-VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
           LL    P    T   +  T LH AA  GH    K+LL + +  P+ R   G T L  A +
Sbjct: 330 LLQHKAPVDDVTLDYL--TALHVAAHCGHYRVTKLLLDK-RANPNARALNGFTPLHIACK 386

Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
              I V  LL+ ++GA + A    G   +H AA  G    +  L+   G   DV      
Sbjct: 387 KNRIKVMELLV-KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN-GASPDVTNIRGE 444

Query: 275 LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQ 328
            TALH AA+ G    ++ LL  GA ++++  + ++ LH+A         + LLQ
Sbjct: 445 -TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 497



 Score =  100 bits (249), Expect = 2e-21
 Identities = 106/357 (29%), Positives = 156/357 (43%), Gaps = 49/357 (13%)

Query: 15  QEGRLRALKEELQAAGGCPGPA---GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDY 71
           +EG +  L +EL   G     A   G+T LH A+  G  +V+  L +  G +I A +++ 
Sbjct: 52  KEGHV-GLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE-GANINAQSQNG 109

Query: 72  KRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEH----- 126
             PL+ AA   H D V+YLL  GA      +  +TPL +A  + +   +  L+E+     
Sbjct: 110 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 169

Query: 127 ----------------GANPLLKN----------------KDGWNSFHIASREGDPLILQ 154
                            A  LL+N                + G+   HIA+  G+  +  
Sbjct: 170 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 229

Query: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRC-QYEPDYRDNCGVTALMDAI 213
            LL     A    ++   TPLH A+  G+   VK+LL R  Q +   RD  G+T L  A 
Sbjct: 230 LLLNR-GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD--GLTPLHCAA 286

Query: 214 QCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATST 273
           + GH  V  LLL E GA L A    G   LH AA     E ++ L+       DV  T  
Sbjct: 287 RSGHDQVVELLL-ERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDV--TLD 343

Query: 274 HLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
           +LTALH AA  GH    + LL   A+ N++     + LH+AC    +   + L++ G
Sbjct: 344 YLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 400



 Score = 75.1 bits (183), Expect = 9e-14
 Identities = 57/188 (30%), Positives = 85/188 (45%), Gaps = 3/188 (1%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G T LH AA+     + + L   +G +     +    PLH A+  GH D V  LL +GA 
Sbjct: 608 GYTPLHIAAKKNQMQIASTLLN-YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 666

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
           +    K+  T L +A     + V   L +HGA+     K G+    +A   G+  ++ +L
Sbjct: 667 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 726

Query: 157 LTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCG 216
           L         ++K   TPLH AA  GH   + VLL+    +P+     G TAL  A + G
Sbjct: 727 LKQGANV-NAKTKNGYTPLHQAAQQGHTHIINVLLQH-GAKPNATTANGNTALAIAKRLG 784

Query: 217 HIDVARLL 224
           +I V   L
Sbjct: 785 YISVVDTL 792



 Score = 72.8 bits (177), Expect = 5e-13
 Identities = 75/240 (31%), Positives = 111/240 (46%), Gaps = 18/240 (7%)

Query: 100 LKKADWTPLMMACTRK-NLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLT 158
           L+K+D     +   R  NL  + E ++ G +    N++G N+ H+A++EG   ++Q LL 
Sbjct: 5   LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64

Query: 159 VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHI 218
               +  + +K   T LH A++ G  E VKVL+K          N G T L  A Q  HI
Sbjct: 65  -RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQN-GFTPLYMAAQENHI 122

Query: 219 DVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTAL 278
           DV + LL E+GA  S     G   L  A   G ++A+  L+       D +     L AL
Sbjct: 123 DVVKYLL-ENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-----DTKG-KVRLPAL 175

Query: 279 HYAAKEGHTSTIQTLL--SLGADINSKDEKNRSA------LHLACAGQHLACAKFLLQSG 330
           H AA++  T +   LL     AD+ SK   NR+       LH+A    ++  A  LL  G
Sbjct: 176 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 235



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 45/155 (29%), Positives = 79/155 (50%), Gaps = 4/155 (2%)

Query: 178 AAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDS 237
           AA  G+L+ V   LK    + +  +  G+ AL  A + GH+ + + LL   G+ + +   
Sbjct: 17  AARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGR-GSSVDSATK 74

Query: 238 LGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLG 297
            G  ALH A++ GQ E ++ LV E G +++ ++ +   T L+ AA+E H   ++ LL  G
Sbjct: 75  KGNTALHIASLAGQAEVVKVLVKE-GANINAQSQNG-FTPLYMAAQENHIDVVKYLLENG 132

Query: 298 ADINSKDEKNRSALHLACAGQHLACAKFLLQSGLK 332
           A+ ++  E   + L +A    H      LL++  K
Sbjct: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK 167



 Score = 52.0 bits (123), Expect = 8e-07
 Identities = 37/127 (29%), Positives = 64/127 (50%), Gaps = 3/127 (2%)

Query: 208 ALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVD 267
           + + A + G++D     L + G  ++  +  G  ALH AA  G    ++ L+   G  VD
Sbjct: 13  SFLRAARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR-GSSVD 70

Query: 268 VRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLL 327
             AT    TALH A+  G    ++ L+  GA+IN++ +   + L++A    H+   K+LL
Sbjct: 71  -SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL 129

Query: 328 QSGLKDS 334
           ++G   S
Sbjct: 130 ENGANQS 136



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 41/135 (30%), Positives = 62/135 (45%), Gaps = 1/135 (0%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +G T LH AA+    +V   L +  G D +A  +    PL  A   G+   V +LL +GA
Sbjct: 673 SGLTSLHLAAQEDKVNVADILTKH-GADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGA 731

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
            V+   K  +TPL  A  + +  +I  L++HGA P     +G  +  IA R G   ++  
Sbjct: 732 NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDT 791

Query: 156 LLTVCPGAWKTESKI 170
           L  V      T + I
Sbjct: 792 LKVVTEEVTTTTTTI 806


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  123 bits (309), Expect = 2e-28
 Identities = 98/295 (33%), Positives = 145/295 (49%), Gaps = 6/295 (2%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +G T +H AA  GH +++  L +  G   + TN   +  LH AA  G  + VR LL  GA
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQN-GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 488

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
            VD   + + TPL +A       ++Q L++H A+P     +G+   HI++REG   +   
Sbjct: 489 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 548

Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
           LL     A    +K   TPLH AA +G L+  K+LL+R +   D     G+T L  A   
Sbjct: 549 LLE-AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR-RAAADSAGKNGLTPLHVAAHY 606

Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
            +  VA LLL E GA   A    G   LH AA   Q +    L++  G + ++  T   +
Sbjct: 607 DNQKVALLLL-EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN-YGAETNI-VTKQGV 663

Query: 276 TALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
           T LH A++EGHT  +  LL  GA+I+   +   ++LHLA     +  A  L + G
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG 718



 Score =  118 bits (295), Expect = 9e-27
 Identities = 99/279 (35%), Positives = 135/279 (48%), Gaps = 8/279 (2%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G T LH +AR G  DV + L EA      AT + +  PLH AA  G  D  + LL R AA
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFT-PLHVAAKYGSLDVAKLLLQRRAA 588

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
            D   K   TPL +A    N  V   L+E GA+P    K+G+   HIA+++    I   L
Sbjct: 589 ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 648

Query: 157 LTVCPGA-WKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
           L    GA     +K   TPLH A+  GH + V +LL +           G+T+L  A Q 
Sbjct: 649 LNY--GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-NIHMSTKSGLTSLHLAAQE 705

Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
             ++VA +L  +HGA   A   LG   L  A   G  + + FL+ + G +V+ + T    
Sbjct: 706 DKVNVADILT-KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ-GANVNAK-TKNGY 762

Query: 276 TALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLA 314
           T LH AA++GHT  I  LL  GA  N+      +AL +A
Sbjct: 763 TPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801



 Score =  117 bits (292), Expect = 2e-26
 Identities = 100/323 (30%), Positives = 153/323 (47%), Gaps = 45/323 (13%)

Query: 44  AARHGHRD-VLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKK 102
           AAR G+ D V+ YL    G+DI   N++    LH AA  GH   V+ LLGRG++VD   K
Sbjct: 38  AARAGNLDKVVEYLKG--GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95

Query: 103 ADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPG 162
              T L +A       V++ LV+ GAN   ++++G+   ++A++E    +++YLL    G
Sbjct: 96  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE--NG 153

Query: 163 A-WKTESKIRRTPLHTAAMHGHLEAVKVLLK----------------------------R 193
           A   T ++   TPL  A   GH +AV +LL+                            +
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213

Query: 194 CQYEPDYRD--------NCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHR 245
             +  D +           G T L  A   G+++VA LLL+  GA +      G   LH 
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN-RGAAVDFTARNGITPLHV 272

Query: 246 AAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDE 305
           A+  G    ++ L+ + G  +D + T   LT LH AA+ GH   ++ LL  GA + ++ +
Sbjct: 273 ASKRGNTNMVKLLL-DRGGQIDAK-TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330

Query: 306 KNRSALHLACAGQHLACAKFLLQ 328
              S LH+A  G H+ C K LLQ
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQ 353



 Score =  108 bits (271), Expect = 6e-24
 Identities = 87/270 (32%), Positives = 132/270 (48%), Gaps = 7/270 (2%)

Query: 62  MDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQ 121
           M +  T      PLH AA  G+ +    LL RGAAVD   +   TPL +A  R N  +++
Sbjct: 224 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283

Query: 122 ELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTV-CPGAWKTESKIRRTPLHTAAM 180
            L++ G     K +DG    H A+R G   +++ LL    P   +T++ +  +PLH AA 
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL--SPLHMAAQ 341

Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
             H+E VK LL+      D   +  +TAL  A  CGH  V +LLLD+  A  +A    G 
Sbjct: 342 GDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDKR-ANPNARALNGF 399

Query: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADI 300
             LH A    + + +  LV + G  +    T + LT +H AA  GH + +  LL  GA  
Sbjct: 400 TPLHIACKKNRIKVMELLV-KYGASIQA-ITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457

Query: 301 NSKDEKNRSALHLACAGQHLACAKFLLQSG 330
           +  + +  +ALH+A     +   + LL++G
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNG 487



 Score =  103 bits (257), Expect = 2e-22
 Identities = 90/294 (30%), Positives = 141/294 (47%), Gaps = 8/294 (2%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +G T LH AA +G+ +V   L    G  ++ T R+   PLH A+  G+ + V+ LL RG 
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNR-GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 290

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
            +D   +   TPL  A    +  V++ L+E GA  L + K+G +  H+A++      +++
Sbjct: 291 QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350

Query: 156 LLT-VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
           LL    P    T   +  T LH AA  GH    K+LL + +  P+ R   G T L  A +
Sbjct: 351 LLQHKAPVDDVTLDYL--TALHVAAHCGHYRVTKLLLDK-RANPNARALNGFTPLHIACK 407

Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
              I V  LL+ ++GA + A    G   +H AA  G    +  L+   G   DV      
Sbjct: 408 KNRIKVMELLV-KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN-GASPDVTNIRGE 465

Query: 275 LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQ 328
            TALH AA+ G    ++ LL  GA ++++  + ++ LH+A         + LLQ
Sbjct: 466 -TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518



 Score =  100 bits (249), Expect = 2e-21
 Identities = 106/357 (29%), Positives = 156/357 (43%), Gaps = 49/357 (13%)

Query: 15  QEGRLRALKEELQAAGGCPGPA---GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDY 71
           +EG +  L +EL   G     A   G+T LH A+  G  +V+  L +  G +I A +++ 
Sbjct: 73  KEGHV-GLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE-GANINAQSQNG 130

Query: 72  KRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEH----- 126
             PL+ AA   H D V+YLL  GA      +  +TPL +A  + +   +  L+E+     
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 190

Query: 127 ----------------GANPLLKN----------------KDGWNSFHIASREGDPLILQ 154
                            A  LL+N                + G+   HIA+  G+  +  
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250

Query: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRC-QYEPDYRDNCGVTALMDAI 213
            LL     A    ++   TPLH A+  G+   VK+LL R  Q +   RD  G+T L  A 
Sbjct: 251 LLLNR-GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD--GLTPLHCAA 307

Query: 214 QCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATST 273
           + GH  V  LLL E GA L A    G   LH AA     E ++ L+       DV  T  
Sbjct: 308 RSGHDQVVELLL-ERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDV--TLD 364

Query: 274 HLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
           +LTALH AA  GH    + LL   A+ N++     + LH+AC    +   + L++ G
Sbjct: 365 YLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 421



 Score = 75.1 bits (183), Expect = 9e-14
 Identities = 57/188 (30%), Positives = 85/188 (45%), Gaps = 3/188 (1%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G T LH AA+     + + L   +G +     +    PLH A+  GH D V  LL +GA 
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLN-YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 687

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
           +    K+  T L +A     + V   L +HGA+     K G+    +A   G+  ++ +L
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747

Query: 157 LTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCG 216
           L         ++K   TPLH AA  GH   + VLL+    +P+     G TAL  A + G
Sbjct: 748 LKQGANV-NAKTKNGYTPLHQAAQQGHTHIINVLLQH-GAKPNATTANGNTALAIAKRLG 805

Query: 217 HIDVARLL 224
           +I V   L
Sbjct: 806 YISVVDTL 813



 Score = 72.8 bits (177), Expect = 5e-13
 Identities = 75/239 (31%), Positives = 110/239 (46%), Gaps = 18/239 (7%)

Query: 101 KKADWTPLMMACTRK-NLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTV 159
           KK+D     +   R  NL  + E ++ G +    N++G N+ H+A++EG   ++Q LL  
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG- 85

Query: 160 CPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHID 219
              +  + +K   T LH A++ G  E VKVL+K          N G T L  A Q  HID
Sbjct: 86  RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQN-GFTPLYMAAQENHID 144

Query: 220 VARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALH 279
           V + LL E+GA  S     G   L  A   G ++A+  L+       D +     L ALH
Sbjct: 145 VVKYLL-ENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-----DTKG-KVRLPALH 197

Query: 280 YAAKEGHTSTIQTLL--SLGADINSKDEKNRSA------LHLACAGQHLACAKFLLQSG 330
            AA++  T +   LL     AD+ SK   NR+       LH+A    ++  A  LL  G
Sbjct: 198 IAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 256



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 45/155 (29%), Positives = 79/155 (50%), Gaps = 4/155 (2%)

Query: 178 AAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDS 237
           AA  G+L+ V   LK    + +  +  G+ AL  A + GH+ + + LL   G+ + +   
Sbjct: 38  AARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGR-GSSVDSATK 95

Query: 238 LGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLG 297
            G  ALH A++ GQ E ++ LV E G +++ ++ +   T L+ AA+E H   ++ LL  G
Sbjct: 96  KGNTALHIASLAGQAEVVKVLVKE-GANINAQSQNG-FTPLYMAAQENHIDVVKYLLENG 153

Query: 298 ADINSKDEKNRSALHLACAGQHLACAKFLLQSGLK 332
           A+ ++  E   + L +A    H      LL++  K
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK 188



 Score = 52.0 bits (123), Expect = 8e-07
 Identities = 37/127 (29%), Positives = 64/127 (50%), Gaps = 3/127 (2%)

Query: 208 ALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVD 267
           + + A + G++D     L + G  ++  +  G  ALH AA  G    ++ L+   G  VD
Sbjct: 34  SFLRAARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR-GSSVD 91

Query: 268 VRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLL 327
             AT    TALH A+  G    ++ L+  GA+IN++ +   + L++A    H+   K+LL
Sbjct: 92  -SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL 150

Query: 328 QSGLKDS 334
           ++G   S
Sbjct: 151 ENGANQS 157



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 41/135 (30%), Positives = 62/135 (45%), Gaps = 1/135 (0%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +G T LH AA+    +V   L +  G D +A  +    PL  A   G+   V +LL +GA
Sbjct: 694 SGLTSLHLAAQEDKVNVADILTKH-GADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGA 752

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
            V+   K  +TPL  A  + +  +I  L++HGA P     +G  +  IA R G   ++  
Sbjct: 753 NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDT 812

Query: 156 LLTVCPGAWKTESKI 170
           L  V      T + I
Sbjct: 813 LKVVTEEVTTTTTTI 827


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  123 bits (309), Expect = 2e-28
 Identities = 98/295 (33%), Positives = 145/295 (49%), Gaps = 6/295 (2%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +G T +H AA  GH +++  L +  G   + TN   +  LH AA  G  + VR LL  GA
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQN-GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 488

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
            VD   + + TPL +A       ++Q L++H A+P     +G+   HI++REG   +   
Sbjct: 489 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 548

Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
           LL     A    +K   TPLH AA +G L+  K+LL+R +   D     G+T L  A   
Sbjct: 549 LLE-AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR-RAAADSAGKNGLTPLHVAAHY 606

Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
            +  VA LLL E GA   A    G   LH AA   Q +    L++  G + ++  T   +
Sbjct: 607 DNQKVALLLL-EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN-YGAETNI-VTKQGV 663

Query: 276 TALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
           T LH A++EGHT  +  LL  GA+I+   +   ++LHLA     +  A  L + G
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG 718



 Score =  118 bits (295), Expect = 9e-27
 Identities = 99/279 (35%), Positives = 135/279 (48%), Gaps = 8/279 (2%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G T LH +AR G  DV + L EA      AT + +  PLH AA  G  D  + LL R AA
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFT-PLHVAAKYGSLDVAKLLLQRRAA 588

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
            D   K   TPL +A    N  V   L+E GA+P    K+G+   HIA+++    I   L
Sbjct: 589 ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 648

Query: 157 LTVCPGA-WKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
           L    GA     +K   TPLH A+  GH + V +LL +           G+T+L  A Q 
Sbjct: 649 LNY--GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-NIHMSTKSGLTSLHLAAQE 705

Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
             ++VA +L  +HGA   A   LG   L  A   G  + + FL+ + G +V+ + T    
Sbjct: 706 DKVNVADILT-KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ-GANVNAK-TKNGY 762

Query: 276 TALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLA 314
           T LH AA++GHT  I  LL  GA  N+      +AL +A
Sbjct: 763 TPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801



 Score =  117 bits (292), Expect = 2e-26
 Identities = 100/323 (30%), Positives = 153/323 (47%), Gaps = 45/323 (13%)

Query: 44  AARHGHRD-VLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKK 102
           AAR G+ D V+ YL    G+DI   N++    LH AA  GH   V+ LLGRG++VD   K
Sbjct: 38  AARAGNLDKVVEYLKG--GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95

Query: 103 ADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPG 162
              T L +A       V++ LV+ GAN   ++++G+   ++A++E    +++YLL    G
Sbjct: 96  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE--NG 153

Query: 163 A-WKTESKIRRTPLHTAAMHGHLEAVKVLLK----------------------------R 193
           A   T ++   TPL  A   GH +AV +LL+                            +
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213

Query: 194 CQYEPDYRD--------NCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHR 245
             +  D +           G T L  A   G+++VA LLL+  GA +      G   LH 
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN-RGAAVDFTARNGITPLHV 272

Query: 246 AAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDE 305
           A+  G    ++ L+ + G  +D + T   LT LH AA+ GH   ++ LL  GA + ++ +
Sbjct: 273 ASKRGNTNMVKLLL-DRGGQIDAK-TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330

Query: 306 KNRSALHLACAGQHLACAKFLLQ 328
              S LH+A  G H+ C K LLQ
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQ 353



 Score =  108 bits (271), Expect = 6e-24
 Identities = 87/270 (32%), Positives = 132/270 (48%), Gaps = 7/270 (2%)

Query: 62  MDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQ 121
           M +  T      PLH AA  G+ +    LL RGAAVD   +   TPL +A  R N  +++
Sbjct: 224 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283

Query: 122 ELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTV-CPGAWKTESKIRRTPLHTAAM 180
            L++ G     K +DG    H A+R G   +++ LL    P   +T++ +  +PLH AA 
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL--SPLHMAAQ 341

Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
             H+E VK LL+      D   +  +TAL  A  CGH  V +LLLD+  A  +A    G 
Sbjct: 342 GDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDKR-ANPNARALNGF 399

Query: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADI 300
             LH A    + + +  LV + G  +    T + LT +H AA  GH + +  LL  GA  
Sbjct: 400 TPLHIACKKNRIKVMELLV-KYGASIQA-ITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457

Query: 301 NSKDEKNRSALHLACAGQHLACAKFLLQSG 330
           +  + +  +ALH+A     +   + LL++G
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNG 487



 Score =  103 bits (257), Expect = 2e-22
 Identities = 90/294 (30%), Positives = 141/294 (47%), Gaps = 8/294 (2%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +G T LH AA +G+ +V   L    G  ++ T R+   PLH A+  G+ + V+ LL RG 
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNR-GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 290

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
            +D   +   TPL  A    +  V++ L+E GA  L + K+G +  H+A++      +++
Sbjct: 291 QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350

Query: 156 LLT-VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
           LL    P    T   +  T LH AA  GH    K+LL + +  P+ R   G T L  A +
Sbjct: 351 LLQHKAPVDDVTLDYL--TALHVAAHCGHYRVTKLLLDK-RANPNARALNGFTPLHIACK 407

Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
              I V  LL+ ++GA + A    G   +H AA  G    +  L+   G   DV      
Sbjct: 408 KNRIKVMELLV-KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN-GASPDVTNIRGE 465

Query: 275 LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQ 328
            TALH AA+ G    ++ LL  GA ++++  + ++ LH+A         + LLQ
Sbjct: 466 -TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518



 Score =  100 bits (249), Expect = 2e-21
 Identities = 106/357 (29%), Positives = 156/357 (43%), Gaps = 49/357 (13%)

Query: 15  QEGRLRALKEELQAAGGCPGPA---GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDY 71
           +EG +  L +EL   G     A   G+T LH A+  G  +V+  L +  G +I A +++ 
Sbjct: 73  KEGHV-GLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE-GANINAQSQNG 130

Query: 72  KRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEH----- 126
             PL+ AA   H D V+YLL  GA      +  +TPL +A  + +   +  L+E+     
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 190

Query: 127 ----------------GANPLLKN----------------KDGWNSFHIASREGDPLILQ 154
                            A  LL+N                + G+   HIA+  G+  +  
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250

Query: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRC-QYEPDYRDNCGVTALMDAI 213
            LL     A    ++   TPLH A+  G+   VK+LL R  Q +   RD  G+T L  A 
Sbjct: 251 LLLNR-GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD--GLTPLHCAA 307

Query: 214 QCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATST 273
           + GH  V  LLL E GA L A    G   LH AA     E ++ L+       DV  T  
Sbjct: 308 RSGHDQVVELLL-ERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDV--TLD 364

Query: 274 HLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
           +LTALH AA  GH    + LL   A+ N++     + LH+AC    +   + L++ G
Sbjct: 365 YLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 421



 Score = 75.1 bits (183), Expect = 9e-14
 Identities = 57/188 (30%), Positives = 85/188 (45%), Gaps = 3/188 (1%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G T LH AA+     + + L   +G +     +    PLH A+  GH D V  LL +GA 
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLN-YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 687

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
           +    K+  T L +A     + V   L +HGA+     K G+    +A   G+  ++ +L
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747

Query: 157 LTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCG 216
           L         ++K   TPLH AA  GH   + VLL+    +P+     G TAL  A + G
Sbjct: 748 LKQGANV-NAKTKNGYTPLHQAAQQGHTHIINVLLQH-GAKPNATTANGNTALAIAKRLG 805

Query: 217 HIDVARLL 224
           +I V   L
Sbjct: 806 YISVVDTL 813



 Score = 72.8 bits (177), Expect = 5e-13
 Identities = 75/239 (31%), Positives = 110/239 (46%), Gaps = 18/239 (7%)

Query: 101 KKADWTPLMMACTRK-NLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTV 159
           KK+D     +   R  NL  + E ++ G +    N++G N+ H+A++EG   ++Q LL  
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG- 85

Query: 160 CPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHID 219
              +  + +K   T LH A++ G  E VKVL+K          N G T L  A Q  HID
Sbjct: 86  RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQN-GFTPLYMAAQENHID 144

Query: 220 VARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALH 279
           V + LL E+GA  S     G   L  A   G ++A+  L+       D +     L ALH
Sbjct: 145 VVKYLL-ENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-----DTKG-KVRLPALH 197

Query: 280 YAAKEGHTSTIQTLL--SLGADINSKDEKNRSA------LHLACAGQHLACAKFLLQSG 330
            AA++  T +   LL     AD+ SK   NR+       LH+A    ++  A  LL  G
Sbjct: 198 IAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 256



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 45/155 (29%), Positives = 79/155 (50%), Gaps = 4/155 (2%)

Query: 178 AAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDS 237
           AA  G+L+ V   LK    + +  +  G+ AL  A + GH+ + + LL   G+ + +   
Sbjct: 38  AARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGR-GSSVDSATK 95

Query: 238 LGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLG 297
            G  ALH A++ GQ E ++ LV E G +++ ++ +   T L+ AA+E H   ++ LL  G
Sbjct: 96  KGNTALHIASLAGQAEVVKVLVKE-GANINAQSQNG-FTPLYMAAQENHIDVVKYLLENG 153

Query: 298 ADINSKDEKNRSALHLACAGQHLACAKFLLQSGLK 332
           A+ ++  E   + L +A    H      LL++  K
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK 188



 Score = 52.0 bits (123), Expect = 8e-07
 Identities = 37/127 (29%), Positives = 64/127 (50%), Gaps = 3/127 (2%)

Query: 208 ALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVD 267
           + + A + G++D     L + G  ++  +  G  ALH AA  G    ++ L+   G  VD
Sbjct: 34  SFLRAARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR-GSSVD 91

Query: 268 VRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLL 327
             AT    TALH A+  G    ++ L+  GA+IN++ +   + L++A    H+   K+LL
Sbjct: 92  -SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL 150

Query: 328 QSGLKDS 334
           ++G   S
Sbjct: 151 ENGANQS 157



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 41/135 (30%), Positives = 62/135 (45%), Gaps = 1/135 (0%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +G T LH AA+    +V   L +  G D +A  +    PL  A   G+   V +LL +GA
Sbjct: 694 SGLTSLHLAAQEDKVNVADILTKH-GADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGA 752

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
            V+   K  +TPL  A  + +  +I  L++HGA P     +G  +  IA R G   ++  
Sbjct: 753 NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDT 812

Query: 156 LLTVCPGAWKTESKI 170
           L  V      T + I
Sbjct: 813 LKVVTEEVTTTTTTI 827


>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
           sapiens]
          Length = 587

 Score =  122 bits (305), Expect = 6e-28
 Identities = 104/353 (29%), Positives = 158/353 (44%), Gaps = 27/353 (7%)

Query: 4   PGDPRRLCRLVQEGRLRALKEELQAAGGC--PGPAGDTLLHCAARHGHRDVLAYLAEAWG 61
           P DP  L + +++G   ALK  ++       P   G   LH AA +G    L  L  A+ 
Sbjct: 57  PADP--LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYP 114

Query: 62  MDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQ 121
             I+      +  ++ A   GH DC+  LL  GA  D   K+  TPL  AC RKN   ++
Sbjct: 115 GTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVK 174

Query: 122 ELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESK--IRRTPLHTAA 179
            LV+H A+   +   GW + H +    D  ++Q L++   G  K ESK     TPL  AA
Sbjct: 175 ILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVS---GGAKVESKNAYGITPLFVAA 231

Query: 180 MHGHLEAVKVLLKRCQYEPDYRDNC--GVTALMDAIQCGHIDVARLLLDEHGACLSAEDS 237
             G LEA++ L K   Y  D         +AL +A +  H +V   LL + GA  +  + 
Sbjct: 232 QSGQLEALRFLAK---YGADINTQASDNASALYEACKNEHEEVVEFLLSQ-GADANKTNK 287

Query: 238 LGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLG 297
            G   LH A+  G    ++ L   L V    R   + ++ LH AA+  H   ++ LLS  
Sbjct: 288 DGLLPLHIASKKGNYRIVQML---LPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSAR 344

Query: 298 ADINSK---------DEKNRSALHLACAGQHLACAKFLLQSGLKDSEDITGTL 341
            D+N+          +++  SAL+ A    ++   + LLQ G   + D+   L
Sbjct: 345 FDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPL 397


>gi|110431370 espin [Homo sapiens]
          Length = 854

 Score =  119 bits (298), Expect = 4e-27
 Identities = 96/318 (30%), Positives = 148/318 (46%), Gaps = 10/318 (3%)

Query: 15  QEGRLRALKEELQAAGGCPGPAGDTL----LHCAARHGHRDVLAYLAEAWGMDIEATNRD 70
           ++G L  L+  L AAG       D L    +H AAR G    L +L E   +   A  R+
Sbjct: 11  RQGELDVLRS-LHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARN 69

Query: 71  YKRPLHEAASMGHRDCVRYLLGRGAA-VDCLKKADWTPLMMACTRKNLGVIQELVEHGA- 128
              P H+A++ GH  C+++LL +G   V     +  T L +A    +  V+  L+ HG  
Sbjct: 70  GATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGG 129

Query: 129 NPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVK 188
           +P      G    H A+ +GD   L+ L+   P     ++K   TPL+ A   GHLE  +
Sbjct: 130 DPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQ 189

Query: 189 VLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAV 248
            L++ C  +P  R + G+T L  A Q GH  V   L+      LS +D  GA A+H AA 
Sbjct: 190 YLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAAS 249

Query: 249 TGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNR 308
            G  + + +L+   G   ++ A     T LH AA+ G     Q L+  GA+++ +D    
Sbjct: 250 RGHTKVLSWLLLHGG---EISADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGY 306

Query: 309 SALHLACAGQHLACAKFL 326
           +A  L+    H  C ++L
Sbjct: 307 TAADLSDFNGHSHCTRYL 324



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 51/186 (27%), Positives = 87/186 (46%), Gaps = 2/186 (1%)

Query: 144 ASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDN 203
           A+R+G+  +L+ L             +   P+H AA  G L  ++ L++        R  
Sbjct: 9   AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68

Query: 204 CGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELG 263
            G T   DA   GH+   + LL + G  +  +D+ GA  LH AA  G  E + +L+   G
Sbjct: 69  NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128

Query: 264 VDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGAD-INSKDEKNRSALHLACAGQHLAC 322
            D    AT      +HYAA +G   +++ L+    + +N++ +   + L+LAC   HL  
Sbjct: 129 GD-PTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEV 187

Query: 323 AKFLLQ 328
            ++L+Q
Sbjct: 188 TQYLVQ 193



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 47/151 (31%), Positives = 70/151 (46%), Gaps = 10/151 (6%)

Query: 15  QEGRLRALKEELQAAGGCPGPA---GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDY 71
           QEG L   +  +Q  G  P      G T LH AA+ GH  V+ +L     + +   ++D 
Sbjct: 181 QEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDG 240

Query: 72  KRPLHEAASMGHRDCVRYLLGRGAAVDCLKKAD-W--TPLMMACTRKNLGVIQELVEHGA 128
              +H AAS GH   + +LL  G  +     AD W  TPL  A     L   Q LV +GA
Sbjct: 241 ATAMHFAASRGHTKVLSWLLLHGGEIS----ADLWGGTPLHDAAENGELECCQILVVNGA 296

Query: 129 NPLLKNKDGWNSFHIASREGDPLILQYLLTV 159
              ++++DG+ +  ++   G     +YL TV
Sbjct: 297 ELDVRDRDGYTAADLSDFNGHSHCTRYLRTV 327



 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 44/125 (35%), Positives = 58/125 (46%), Gaps = 8/125 (6%)

Query: 210 MDAIQCGHIDVARLLLDEHGACL---SAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDV 266
           + A + G +DV R L   H A L   S  D L A  +H AA  G+   +RFLV E  +  
Sbjct: 7   LQAARQGELDVLRSL---HAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPA 63

Query: 267 DVRATSTHLTALHYAAKEGHTSTIQTLLSLGA-DINSKDEKNRSALHLACAGQHLACAKF 325
             RA +   T  H A+  GH + +Q LLS G   +  KD    + LHLA    H     +
Sbjct: 64  AARARNG-ATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNW 122

Query: 326 LLQSG 330
           LL  G
Sbjct: 123 LLHHG 127


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  115 bits (288), Expect = 6e-26
 Identities = 102/332 (30%), Positives = 146/332 (43%), Gaps = 38/332 (11%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G T LH AA +GH +++  L  A G +I A ++  +R LH AA MGH D V  L+  GA 
Sbjct: 115 GRTALHHAALNGHVEMVNLLL-AKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAE 173

Query: 97  VDCLKKADWTPLMMACTR---------KNLG------------------------VIQEL 123
           V C  K  +TPL  A +           NLG                        V+ EL
Sbjct: 174 VTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNEL 233

Query: 124 VEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGH 183
           +++GAN    N +G+   H A+      +   LL         +SK  ++PLH  A+HG 
Sbjct: 234 IDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGR 293

Query: 184 LEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQAL 243
               + L++    E D  D  G T L  A + GH ++    L   GA  +         L
Sbjct: 294 FTRSQTLIQN-GGEIDCVDKDGNTPLHVAARYGH-ELLINTLRTSGADTAKCGIHSMFPL 351

Query: 244 HRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSK 303
           H AA+    +  R L+S  G ++D        T LH AA  G+   I+ L S GAD + K
Sbjct: 352 HLAALNAHSDCCRKLLSS-GFEIDT-PDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409

Query: 304 DEKNRSALHLACAGQHLACAKFLLQSGLKDSE 335
           D+  R+ LH A A  H  C + L+ +G   +E
Sbjct: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVNE 441



 Score =  112 bits (279), Expect = 7e-25
 Identities = 79/269 (29%), Positives = 132/269 (49%), Gaps = 6/269 (2%)

Query: 63  DIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQE 122
           D+   + + + PLH AA +G  + +  L+  GA V+       TPL  A   ++   +Q 
Sbjct: 8   DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67

Query: 123 LVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHG 182
           L++H A+   ++K+     H+A+        + ++ +         +  RT LH AA++G
Sbjct: 68  LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSV-NVSDRGGRTALHHAALNG 126

Query: 183 HLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQA 242
           H+E V +LL +      + D     AL  A   GH+DV  LL++ HGA ++ +D  G   
Sbjct: 127 HVEMVNLLLAKGANINAF-DKKDRRALHWAAYMGHLDVVALLIN-HGAEVTCKDKKGYTP 184

Query: 243 LHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINS 302
           LH AA  GQ   ++ L++ LGV++D        TALH A   G  + +  L+  GA++N 
Sbjct: 185 LHAAASNGQINVVKHLLN-LGVEID-EINVYGNTALHIACYNGQDAVVNELIDYGANVNQ 242

Query: 303 KDEKNRSALHLACAGQHLA-CAKFLLQSG 330
            +    + LH A A  H A C + L+ +G
Sbjct: 243 PNNNGFTPLHFAAASTHGALCLELLVNNG 271



 Score =  106 bits (264), Expect = 4e-23
 Identities = 85/299 (28%), Positives = 132/299 (44%), Gaps = 44/299 (14%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDY-KRPLHEAASMGHRDCVRYLLGRGA 95
           G   +H AA +GHR  L  L E      E ++    K PLH AA  GH   +  LL    
Sbjct: 507 GYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLV 566

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
            +D   +   T L +A  + +   ++ L+  GA+  +K                      
Sbjct: 567 DLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVK---------------------- 604

Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEP--DYRDNCGVTALMDAI 213
                      ++  +RTPLH + ++GH   +++LL+        D +D  G T LM A+
Sbjct: 605 -----------DNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAV 653

Query: 214 QCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATST 273
             GHID   LLL++  A +   D LG  ALHR  +TG +E ++ L+ +   +V +    +
Sbjct: 654 AYGHIDAVSLLLEKE-ANVDTVDILGCTALHRGIMTGHEECVQMLLEQ---EVSILCKDS 709

Query: 274 H-LTALHYAAKEGHTSTIQTLLSLGA---DINSKDEKNRSALHLACAGQHLACAKFLLQ 328
              T LHYAA  GH + +  LL +     D   KD +  + LH AC   +  C + LL+
Sbjct: 710 RGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768



 Score =  101 bits (251), Expect = 1e-21
 Identities = 102/369 (27%), Positives = 156/369 (42%), Gaps = 71/369 (19%)

Query: 33  PGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLG 92
           P   G T LH AA  G+ + +  L  + G D    ++  + PLH AA+  H  C+  L+ 
Sbjct: 376 PDKFGRTCLHAAAAGGNVECIKLLQSS-GADFHKKDKCGRTPLHYAAANCHFHCIETLVT 434

Query: 93  RGAAVDCLKKADW--TPLMMACT------RKNLG----------------------VIQE 122
            GA V+  +  DW  T L  A        +  LG                       ++ 
Sbjct: 435 TGANVN--ETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEF 492

Query: 123 LVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLT-VCPGAWKTESKIRRTPLHTAAMH 181
           L+++ ANP +++K+G+NS H A+  G    L+ LL     G  +++S   ++PLH AA +
Sbjct: 493 LLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYN 552

Query: 182 GHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQ 241
           GH +A++VLL+    + D RD  G TAL  A   GH +    L++  GA +  +D++  +
Sbjct: 553 GHHQALEVLLQSL-VDLDIRDEKGRTALDLAAFKGHTECVEALINP-GASIFVKDNVTKR 610

Query: 242 A-LHRAAVTGQDEAIRFLV----SELGVDVDVRATSTHL--------------------- 275
             LH + + G    +R L+    +   VDV      T L                     
Sbjct: 611 TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670

Query: 276 ---------TALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFL 326
                    TALH     GH   +Q LL     I  KD + R+ LH A A  H      L
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSEL 730

Query: 327 LQSGLKDSE 335
           LQ  L + +
Sbjct: 731 LQMALSEED 739



 Score = 98.6 bits (244), Expect = 8e-21
 Identities = 93/340 (27%), Positives = 139/340 (40%), Gaps = 13/340 (3%)

Query: 17  GRLRALKEELQAAG--GCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRP 74
           GR    +  +Q  G   C    G+T LH AAR+GH ++L       G D          P
Sbjct: 292 GRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGH-ELLINTLRTSGADTAKCGIHSMFP 350

Query: 75  LHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKN 134
           LH AA   H DC R LL  G  +D   K   T L  A    N+  I+ L   GA+   K+
Sbjct: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410

Query: 135 KDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRC 194
           K G    H A+       ++ L+T      +T+    RT LH AA    ++  K +L   
Sbjct: 411 KCGRTPLHYAAANCHFHCIETLVTTGANVNETDDW-GRTALHYAAA-SDMDRNKTILGNA 468

Query: 195 QYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEA 254
               +  +        +A  C         L ++ A  S  D  G  ++H AA  G  + 
Sbjct: 469 HDNSEELERARELKEKEATLCLEF------LLQNDANPSIRDKEGYNSIHYAAAYGHRQC 522

Query: 255 IRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLA 314
           +  L+       +   +    + LH AA  GH   ++ LL    D++ +DEK R+AL LA
Sbjct: 523 LELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLA 582

Query: 315 CAGQHLACAKFLLQSGLKDSEDITGTLAQQLPRRADVLQG 354
               H  C + L+  G   S  +   + ++ P  A V+ G
Sbjct: 583 AFKGHTECVEALINPGA--SIFVKDNVTKRTPLHASVING 620



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 84/278 (30%), Positives = 124/278 (44%), Gaps = 7/278 (2%)

Query: 64  IEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQEL 123
           +  ++R  +  LH AA  GH + V  LL +GA ++   K D   L  A    +L V+  L
Sbjct: 108 VNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALL 167

Query: 124 VEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKI-RRTPLHTAAMHG 182
           + HGA    K+K G+   H A+  G   ++++LL +  G    E  +   T LH A  +G
Sbjct: 168 INHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNL--GVEIDEINVYGNTALHIACYNG 225

Query: 183 HLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQA 242
               V  L+       +  +N G T L  A    H  +   LL  +GA ++ +   G   
Sbjct: 226 QDAVVNELID-YGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSP 284

Query: 243 LHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINS 302
           LH  AV G+    + L+   G ++D        T LH AA+ GH   I TL + GAD   
Sbjct: 285 LHMTAVHGRFTRSQTLIQN-GGEIDC-VDKDGNTPLHVAARYGHELLINTLRTSGADTAK 342

Query: 303 KDEKNRSALHLACAGQHLACAKFLLQSGLK-DSEDITG 339
               +   LHLA    H  C + LL SG + D+ D  G
Sbjct: 343 CGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFG 380



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 93/331 (28%), Positives = 131/331 (39%), Gaps = 44/331 (13%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLL---GR 93
           G T L  AA  GH + +  L           N   + PLH +   GH  C+R LL     
Sbjct: 575 GRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADN 634

Query: 94  GAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLIL 153
             AVD       TPLM+A    ++  +  L+E  AN    +  G  + H     G    +
Sbjct: 635 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 694

Query: 154 QYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPD--YRDNCGVTALMD 211
           Q LL         +S+  RTPLH AA  GH   +  LL+    E D  ++DN G T L  
Sbjct: 695 QMLLEQEVSILCKDSR-GRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHW 753

Query: 212 AIQCGHIDVARLLLDE---------------------HGAC------------LSAEDSL 238
           A   G+ +   +LL++                     HG C            +S  D  
Sbjct: 754 ACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK 813

Query: 239 GAQALHRAAVTGQDEAIRFLVSELGVDVDVRAT-STHLTALHYAAKEGHTSTIQTLL-SL 296
           G   L  AA     E ++ L+        V A  ++  TAL  AA+ G    +  L+ S 
Sbjct: 814 GRTPLRAAAFADHVECLQLLLRH---SAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870

Query: 297 GADINSKDEKNRSALHLACAGQHLACAKFLL 327
            AD+  KD+   + LHLAC+  H  CA  +L
Sbjct: 871 QADLTVKDKDLNTPLHLACSKGHEKCALLIL 901



 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 80/284 (28%), Positives = 122/284 (42%), Gaps = 23/284 (8%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G T L  A  +GH D ++ L E    +++  +      LH     GH +CV+ LL +  +
Sbjct: 645 GQTPLMLAVAYGHIDAVSLLLEKEA-NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVS 703

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGANP---LLKNKDGWNSFHIASREGDPLIL 153
           + C      TPL  A  R +   + EL++   +      K+  G+   H A   G+   +
Sbjct: 704 ILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCI 763

Query: 154 QYLLTVCPGAWKTESKIRR-------TPLHTAAMHGHLEAVKVLLKRCQYE-PDYRDNCG 205
           + LL         E K  R       TPLH A ++ H     +LL          RD+ G
Sbjct: 764 EVLL---------EQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKG 814

Query: 206 VTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVD 265
            T L  A    H++  +LLL  H A ++A D+ G  AL  AA  GQ  A+  LV+    D
Sbjct: 815 RTPLRAAAFADHVECLQLLL-RHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQAD 873

Query: 266 VDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRS 309
           + V+    + T LH A  +GH      +L    D +  +EKN +
Sbjct: 874 LTVKDKDLN-TPLHLACSKGHEKCALLILDKIQDESLINEKNNA 916



 Score = 82.8 bits (203), Expect = 4e-16
 Identities = 84/306 (27%), Positives = 128/306 (41%), Gaps = 13/306 (4%)

Query: 33  PGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLG 92
           P   G T LH AA   H  +   L    G D+   ++D K PLH  A  G     + L+ 
Sbjct: 243 PNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQ 302

Query: 93  RGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLI 152
            G  +DC+ K   TPL +A    +  +I  L   GA+            H+A+       
Sbjct: 303 NGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDC 362

Query: 153 LQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDA 212
            + LL+       T  K  RT LH AA  G++E +K LL+    +   +D CG T L  A
Sbjct: 363 CRKLLS-SGFEIDTPDKFGRTCLHAAAAGGNVECIK-LLQSSGADFHKKDKCGRTPLHYA 420

Query: 213 IQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATS 272
               H      L+   GA ++  D  G  ALH AA +  D     L        +    S
Sbjct: 421 AANCHFHCIETLVTT-GANVNETDDWGRTALHYAAASDMDRNKTIL-------GNAHDNS 472

Query: 273 THLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQ---S 329
             L       ++  T  ++ LL   A+ + +D++  +++H A A  H  C + LL+   S
Sbjct: 473 EELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNS 532

Query: 330 GLKDSE 335
           G ++S+
Sbjct: 533 GFEESD 538



 Score = 36.6 bits (83), Expect = 0.036
 Identities = 18/58 (31%), Positives = 27/58 (46%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGR 93
           +G T L  AA +G    +  L  +   D+   ++D   PLH A S GH  C   +L +
Sbjct: 846 SGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDK 903


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  114 bits (284), Expect = 2e-25
 Identities = 93/283 (32%), Positives = 130/283 (45%), Gaps = 6/283 (2%)

Query: 32  CPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLL 91
           C   +G T L  AA+    D+ A L  A G D    + D   PLH AA  G     R LL
Sbjct: 390 CQTASGYTPLLIAAQDQQPDLCALLL-AHGADANRVDEDGWAPLHFAAQNGDDGTARLLL 448

Query: 92  GRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPL 151
             GA VD  ++  WTPL +A       V + LV   A+P L   +G    H+A+  G   
Sbjct: 449 DHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVS 508

Query: 152 ILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMD 211
           +++ LLT        + +  RTPLH A   G + A++ LLK     PD  D  G   L  
Sbjct: 509 LVK-LLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAV-PDALDQSGYGPLHT 566

Query: 212 AIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRAT 271
           A   G   + ++LL  +GA L      G   LH AA  G  E I  L++E   ++     
Sbjct: 567 AAARGKYLICKMLL-RYGASLELPTHQGWTPLHLAAYKGHLEIIH-LLAESHANMGALG- 623

Query: 272 STHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLA 314
           + + T LH AA+ G  + +  LL  GAD N+ ++   + LHLA
Sbjct: 624 AVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLA 666



 Score =  101 bits (251), Expect = 1e-21
 Identities = 81/258 (31%), Positives = 124/258 (48%), Gaps = 9/258 (3%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G T LH AA  GH  ++  L    G +++A  R+ + PLH A   G    +++LL  GA 
Sbjct: 494 GKTPLHVAAYFGHVSLVKLLTSQ-GAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAV 552

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
            D L ++ + PL  A  R    + + L+ +GA+  L    GW   H+A+ +G  L + +L
Sbjct: 553 PDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGH-LEIIHL 611

Query: 157 LTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ-C 215
           L            +  TPLH AA HG  EAV   L +C  +P+  +  G T L  A+Q  
Sbjct: 612 LAESHANMGALGAVNWTPLHLAARHGE-EAVVSALLQCGADPNAAEQSGWTPLHLAVQRS 670

Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVR--ATST 273
             + V  LL  EH A + A + +G    H AA+ G    ++ LV E G  +DV+   + T
Sbjct: 671 TFLSVINLL--EHHANVHARNKVGWTPAHLAALKGNTAILKVLV-EAGAQLDVQDGVSCT 727

Query: 274 HLTALHYAAKEGHTSTIQ 291
            L     + K+G  S ++
Sbjct: 728 PLQLALRSRKQGIMSFLE 745



 Score = 95.9 bits (237), Expect = 5e-20
 Identities = 80/258 (31%), Positives = 117/258 (45%), Gaps = 9/258 (3%)

Query: 74  PLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLK 133
           PLH   + G  + VR LL     VDC   + +TPL++A   +   +   L+ HGA+    
Sbjct: 365 PLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRV 424

Query: 134 NKDGWNSFHIASREGDPLILQYLLT--VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLL 191
           ++DGW   H A++ GD    + LL    C  A + E     TPLH AA +      ++L+
Sbjct: 425 DEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREG---WTPLHLAAQNNFENVARLLV 481

Query: 192 KRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQ 251
            R Q +P+  +  G T L  A   GH+ + +LL  + GA L A+       LH A   G+
Sbjct: 482 SR-QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQ-GAELDAQQRNLRTPLHLAVERGK 539

Query: 252 DEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSAL 311
             AI+ L+   G   D    S +   LH AA  G     + LL  GA +     +  + L
Sbjct: 540 VRAIQHLLKS-GAVPDALDQSGY-GPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597

Query: 312 HLACAGQHLACAKFLLQS 329
           HLA    HL     L +S
Sbjct: 598 HLAAYKGHLEIIHLLAES 615



 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 45/125 (36%), Positives = 65/125 (52%), Gaps = 1/125 (0%)

Query: 33  PGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLG 92
           P   G T LH AA  GH +++  LAE+   ++ A       PLH AA  G    V  LL 
Sbjct: 589 PTHQGWTPLHLAAYKGHLEIIHLLAESHA-NMGALGAVNWTPLHLAARHGEEAVVSALLQ 647

Query: 93  RGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLI 152
            GA  +  +++ WTPL +A  R     +  L+EH AN   +NK GW   H+A+ +G+  I
Sbjct: 648 CGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAI 707

Query: 153 LQYLL 157
           L+ L+
Sbjct: 708 LKVLV 712



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 42/135 (31%), Positives = 57/135 (42%), Gaps = 1/135 (0%)

Query: 22  LKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASM 81
           L  E  A  G  G    T LH AARHG   V++ L +  G D  A  +    PLH A   
Sbjct: 611 LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQC-GADPNAAEQSGWTPLHLAVQR 669

Query: 82  GHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSF 141
                V  LL   A V    K  WTP  +A  + N  +++ LVE GA   +++       
Sbjct: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPL 729

Query: 142 HIASREGDPLILQYL 156
            +A R     I+ +L
Sbjct: 730 QLALRSRKQGIMSFL 744


>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
          Length = 399

 Score =  108 bits (269), Expect = 1e-23
 Identities = 99/299 (33%), Positives = 130/299 (43%), Gaps = 17/299 (5%)

Query: 36  AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           AG T LH A   GH  ++  L +  G  + A +R  +  LHEAA  GH      LL RGA
Sbjct: 73  AGRTPLHLAVLRGHAPLVRLLLQR-GAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGA 131

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEH-GANPLLKNKD---GWNSFHIASREGDPL 151
           +         TPL  A    +  +   L+E  G  P     +   GW + H A+  G   
Sbjct: 132 SAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLA 191

Query: 152 ILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMD 211
           +L+ L     G            L  AA  G   A++ LL R     D RD  G TAL  
Sbjct: 192 VLELLAAGGAGL--------DGALLVAAAAGRGAALRFLLARGA-RVDARDGAGATALGL 242

Query: 212 AIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRAT 271
           A   G      +LL  HGA     D  G  ALHRAA  G   A++ LV++ G +VD R T
Sbjct: 243 AAALGRSQDIEVLLG-HGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQ-GAEVDARDT 300

Query: 272 STHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
              LT LH+A++EGH      LL  GA +++     ++ LHLA    H      LL  G
Sbjct: 301 -LGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRG 358



 Score = 89.0 bits (219), Expect = 6e-18
 Identities = 84/266 (31%), Positives = 113/266 (42%), Gaps = 36/266 (13%)

Query: 105 WTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGD-PLILQYLLTVCPGA 163
           W  L+ A  R   G++ +L+  GA+   ++  G    H+A   G  PL+   L    P  
Sbjct: 42  WGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVG 101

Query: 164 WKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARL 223
                +  RT LH AA HGH    ++LL+R       R   G+T L  A   GH  +A  
Sbjct: 102 --AVDRAGRTALHEAAWHGHSRVAELLLQR-GASAAARSGTGLTPLHWAAALGHTLLAAR 158

Query: 224 LLDEHG---ACLSAEDSLGAQALH--------------------------RAAVTGQDEA 254
           LL+  G   A   AED+ G  A H                           AA  G+  A
Sbjct: 159 LLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAA 218

Query: 255 IRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLA 314
           +RFL++  G  VD R      TAL  AA  G +  I+ LL  GAD   +D   RSALH A
Sbjct: 219 LRFLLAR-GARVDAR-DGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRA 276

Query: 315 CAGQHLACAKFLLQSGLK-DSEDITG 339
            A  HL   + L+  G + D+ D  G
Sbjct: 277 AARGHLLAVQLLVTQGAEVDARDTLG 302



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 62/177 (35%), Positives = 84/177 (47%), Gaps = 21/177 (11%)

Query: 26  LQAAGGCPGPA--------GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHE 77
           L+A G  PGPA        G T  H AA  G   VL  LA A G  ++         L  
Sbjct: 160 LEAPG--PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLA-AGGAGLDGA-------LLV 209

Query: 78  AASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDG 137
           AA+ G    +R+LL RGA VD    A  T L +A        I+ L+ HGA+P ++++ G
Sbjct: 210 AAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHG 269

Query: 138 WNSFHIASREGDPLILQYLLTVCPGA-WKTESKIRRTPLHTAAMHGHLEAVKVLLKR 193
            ++ H A+  G  L +Q L+T   GA       +  TPLH A+  GH+E    LL R
Sbjct: 270 RSALHRAAARGHLLAVQLLVT--QGAEVDARDTLGLTPLHHASREGHVEVAGCLLDR 324



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 38/115 (33%), Positives = 53/115 (46%), Gaps = 4/115 (3%)

Query: 24  EELQAAGGCPGPA---GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAAS 80
           E L   G  PG     G + LH AA  GH  +   L    G +++A +     PLH A+ 
Sbjct: 253 EVLLGHGADPGIRDRHGRSALHRAAARGHL-LAVQLLVTQGAEVDARDTLGLTPLHHASR 311

Query: 81  MGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNK 135
            GH +    LL RGA VD       TPL +A  R +   +  L+  GA+P L+ +
Sbjct: 312 EGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  107 bits (267), Expect = 2e-23
 Identities = 102/335 (30%), Positives = 153/335 (45%), Gaps = 13/335 (3%)

Query: 2   AQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPA--GDTLLHCAARHGHRDVLAYLAEA 59
           A   D R L     EG + A+++ L            G++LL  A   G+ ++   L   
Sbjct: 230 AGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLL-- 287

Query: 60  WGMDIEATNRDYK---RPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKN 116
             M     +R  K    PL  AA+ GH   V+ LL   A V+       T L  AC    
Sbjct: 288 -AMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGY 346

Query: 117 LGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLH 176
           + V++ L+E GA+    N++G      A   G   + + LL    G     ++ + + L 
Sbjct: 347 VDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALT 406

Query: 177 TAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAED 236
            A   GHLE V+ LL+    + +++ +   TALM+A   GH++VARLLLD  GA ++   
Sbjct: 407 LACYKGHLEMVRFLLE-AGADQEHKTDEMHTALMEACMDGHVEVARLLLDS-GAQVNMPA 464

Query: 237 SLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSL 296
                 L  AA  G  E    L+ E G  ++        T L  AA+EGH   +  LL  
Sbjct: 465 DSFESPLTLAACGGHVELAALLI-ERGASLE-EVNDEGYTPLMEAAREGHEEMVALLLGQ 522

Query: 297 GADINSK-DEKNRSALHLACAGQHLACAKFLLQSG 330
           GA+IN++ +E   +AL LAC G  L  A FL+++G
Sbjct: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAG 557



 Score =  107 bits (267), Expect = 2e-23
 Identities = 103/314 (32%), Positives = 149/314 (47%), Gaps = 14/314 (4%)

Query: 38   DTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAV 97
            DT L  A   GH +++  L E  G  IE  ++    PL  AA+ GH   V  LL  GA +
Sbjct: 1084 DTALTLACAGGHEELVQTLLER-GASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADI 1142

Query: 98   DCL-KKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
            +   ++   TPL +AC+     V++ L+  GAN   +N   +    +A+  G   I++ L
Sbjct: 1143 EAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1202

Query: 157  LTVCPGAW---KTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAI 213
            L    GA    +T SK+  +PL  AAM+GH  AVK+LL          +    TAL  A 
Sbjct: 1203 LNA--GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1260

Query: 214  QCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRAT-S 272
              G  +V  LLLD   A +      G   L  AA  G  E  R L+ + G DV+     S
Sbjct: 1261 FQGRTEVVSLLLDRK-ANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK-GADVNAPPVPS 1318

Query: 273  THLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG-- 330
            +  TAL  AA +GH    + L+  GA I+ +++K  + L LA  G HL   + L+Q+G  
Sbjct: 1319 SRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1378

Query: 331  --LKDSEDITGTLA 342
                D+  IT  +A
Sbjct: 1379 VDAADNRKITPLMA 1392



 Score =  106 bits (264), Expect = 4e-23
 Identities = 92/294 (31%), Positives = 137/294 (46%), Gaps = 9/294 (3%)

Query: 38  DTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAV 97
           ++ L  A   GH +++ +L EA G D E    +    L EA   GH +  R LL  GA V
Sbjct: 402 ESALTLACYKGHLEMVRFLLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 460

Query: 98  DCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL 157
           +    +  +PL +A    ++ +   L+E GA+    N +G+     A+REG   ++  LL
Sbjct: 461 NMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL 520

Query: 158 TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
                      + + T L  A   G LE    L+K      D    C  T LM+A Q GH
Sbjct: 521 GQGANINAQTEETQETALTLACCGGFLEVADFLIKA---GADIELGCS-TPLMEAAQEGH 576

Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
           +++ + LL   GA + A  + G  AL  A   G  +    L+ + G D++  +     T 
Sbjct: 577 LELVKYLLAA-GANVHATTATGDTALTYACENGHTDVADVLL-QAGADLEHESEGGR-TP 633

Query: 278 LHYAAKEGHTSTIQTLLSLGADINSKDEKN-RSALHLACAGQHLACAKFLLQSG 330
           L  AA+ GH  T+Q L+S GA++N     N  + L LACAG HLA  + LL  G
Sbjct: 634 LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG 687



 Score =  102 bits (253), Expect = 7e-22
 Identities = 94/297 (31%), Positives = 143/297 (48%), Gaps = 10/297 (3%)

Query: 37   GDTLLHCAARHGHRDVLAYLAEAWGMDIEA-TNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
            G T L  AA  GH  V+  L +  G DIEA + R    PL  A S G ++ V  LL RGA
Sbjct: 1116 GFTPLILAATAGHVGVVEILLDN-GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGA 1174

Query: 96   AVDCLKKADWTPLMMACTRKNLGVIQELVEHGA--NPLLKNKDGWNSFHIASREGDPLIL 153
              +    +D+TPL +A +   + +I+ L+  GA  N    +K G +   +A+  G    +
Sbjct: 1175 NKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAV 1234

Query: 154  QYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAI 213
            + LL +           R T L  A   G  E V +LL R +   ++R   G+T LM+A 
Sbjct: 1235 KLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDR-KANVEHRAKTGLTPLMEAA 1293

Query: 214  QCGHIDVARLLLDEHGACLSAE--DSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRAT 271
              G+ +V R+LLD+ GA ++A    S    AL  AA  G  +    L+   G  +DVR  
Sbjct: 1294 SGGYAEVGRVLLDK-GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR-GAHIDVRNK 1351

Query: 272  STHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQ 328
              + T L  AA  GH   +Q L+  GAD+++ D +  + L  A    H+   ++L++
Sbjct: 1352 KGN-TPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407



 Score =  100 bits (248), Expect = 3e-21
 Identities = 102/360 (28%), Positives = 158/360 (43%), Gaps = 40/360 (11%)

Query: 5   GDPRRLCRLVQEGRLRALKEEL--QAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGM 62
           GD   L      G ++ +K  L  +A        G+T L  A   G+ DV+  L E+ G 
Sbjct: 300 GDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES-GA 358

Query: 63  DIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDC-LKKADWTPLMMACTRKNLGVIQ 121
            IE  N +   PL EA S GH +  R LL  GA ++    +   + L +AC + +L +++
Sbjct: 359 SIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVR 418

Query: 122 ELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAW-KTESKIRRTPLHTAAM 180
            L+E GA+   K  +   +   A  +G   + + LL    GA     +    +PL  AA 
Sbjct: 419 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD--SGAQVNMPADSFESPLTLAAC 476

Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAE-DSLG 239
            GH+E   +L++R     +  D  G T LM+A + GH ++  LLL + GA ++A+ +   
Sbjct: 477 GGHVELAALLIERGASLEEVNDE-GYTPLMEAAREGHEEMVALLLGQ-GANINAQTEETQ 534

Query: 240 AQALHRAAVTGQDEAIRFLVSELGVDVDV-----------------------------RA 270
             AL  A   G  E   FL+ + G D+++                               
Sbjct: 535 ETALTLACCGGFLEVADFLI-KAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHAT 593

Query: 271 TSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
           T+T  TAL YA + GHT     LL  GAD+  + E  R+ L  A    H+   +FL+  G
Sbjct: 594 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKG 653



 Score = 75.9 bits (185), Expect = 5e-14
 Identities = 72/234 (30%), Positives = 104/234 (44%), Gaps = 16/234 (6%)

Query: 2   AQPGDPRRLCRLVQEG-RLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW 60
           A+ G    +  L+ +G  + A  EE Q          +T L  A   G  +V  +L +A 
Sbjct: 508 AREGHEEMVALLLGQGANINAQTEETQ----------ETALTLACCGGFLEVADFLIKA- 556

Query: 61  GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI 120
           G DIE        PL EAA  GH + V+YLL  GA V        T L  AC   +  V 
Sbjct: 557 GADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVA 613

Query: 121 QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM 180
             L++ GA+   +++ G      A+R G    +Q+L++      +T +    T L  A  
Sbjct: 614 DVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACA 673

Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSA 234
            GHL  V++LL     +P +R   G T L++A + GH  V   LLD     LSA
Sbjct: 674 GGHLAVVELLLAH-GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSA 726



 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 65/199 (32%), Positives = 96/199 (48%), Gaps = 16/199 (8%)

Query: 37   GDTLLHCAARHGHRDVLAYLAEAWGMDIEA---TNRDYKRPLHEAASMGHRDCVRYLLGR 93
            G + L  AA +GH   +  L +  G DI A   TNR+    L  A   G  + V  LL R
Sbjct: 1218 GISPLMLAAMNGHTAAVKLLLDM-GSDINAQIETNRNTALTL--ACFQGRTEVVSLLLDR 1274

Query: 94   GAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGAN----PLLKNKDGWNSFHIASREGD 149
             A V+   K   TPLM A +     V + L++ GA+    P+  ++D   +  IA+ +G 
Sbjct: 1275 KANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD--TALTIAADKGH 1332

Query: 150  PLILQYLLTVCPGAW-KTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTA 208
                + L+    GA     +K   TPL  AA  GHL+ V++L++    + D  DN  +T 
Sbjct: 1333 YKFCELLIG--RGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ-AGADVDAADNRKITP 1389

Query: 209  LMDAIQCGHIDVARLLLDE 227
            LM A + GH+ V R L+ E
Sbjct: 1390 LMAAFRKGHVKVVRYLVKE 1408



 Score = 52.0 bits (123), Expect = 8e-07
 Identities = 26/67 (38%), Positives = 36/67 (53%)

Query: 264  VDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACA 323
            +D+D +  S H TAL  A   GH   +QTLL  GA I  +D+K  + L LA    H+   
Sbjct: 1073 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 1132

Query: 324  KFLLQSG 330
            + LL +G
Sbjct: 1133 EILLDNG 1139



 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 43/163 (26%), Positives = 78/163 (47%), Gaps = 4/163 (2%)

Query: 38   DTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAV 97
            +T L  A   G  +V++ L +    ++E   +    PL EAAS G+ +  R LL +GA V
Sbjct: 1253 NTALTLACFQGRTEVVSLLLDRKA-NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1311

Query: 98   DC--LKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
            +   +  +  T L +A  + +    + L+  GA+  ++NK G     +A+  G   ++Q 
Sbjct: 1312 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371

Query: 156  LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEP 198
            L+         +++ + TPL  A   GH++ V+ L+K     P
Sbjct: 1372 LVQAGADVDAADNR-KITPLMAAFRKGHVKVVRYLVKEVNQFP 1413


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
           sapiens]
          Length = 2352

 Score =  107 bits (267), Expect = 2e-23
 Identities = 102/335 (30%), Positives = 153/335 (45%), Gaps = 13/335 (3%)

Query: 2   AQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPA--GDTLLHCAARHGHRDVLAYLAEA 59
           A   D R L     EG + A+++ L            G++LL  A   G+ ++   L   
Sbjct: 230 AGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLL-- 287

Query: 60  WGMDIEATNRDYK---RPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKN 116
             M     +R  K    PL  AA+ GH   V+ LL   A V+       T L  AC    
Sbjct: 288 -AMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGY 346

Query: 117 LGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLH 176
           + V++ L+E GA+    N++G      A   G   + + LL    G     ++ + + L 
Sbjct: 347 VDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALT 406

Query: 177 TAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAED 236
            A   GHLE V+ LL+    + +++ +   TALM+A   GH++VARLLLD  GA ++   
Sbjct: 407 LACYKGHLEMVRFLLE-AGADQEHKTDEMHTALMEACMDGHVEVARLLLDS-GAQVNMPA 464

Query: 237 SLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSL 296
                 L  AA  G  E    L+ E G  ++        T L  AA+EGH   +  LL  
Sbjct: 465 DSFESPLTLAACGGHVELAALLI-ERGASLE-EVNDEGYTPLMEAAREGHEEMVALLLGQ 522

Query: 297 GADINSK-DEKNRSALHLACAGQHLACAKFLLQSG 330
           GA+IN++ +E   +AL LAC G  L  A FL+++G
Sbjct: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAG 557



 Score =  107 bits (267), Expect = 2e-23
 Identities = 103/314 (32%), Positives = 149/314 (47%), Gaps = 14/314 (4%)

Query: 38   DTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAV 97
            DT L  A   GH +++  L E  G  IE  ++    PL  AA+ GH   V  LL  GA +
Sbjct: 833  DTALTLACAGGHEELVQTLLER-GASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADI 891

Query: 98   DCL-KKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
            +   ++   TPL +AC+     V++ L+  GAN   +N   +    +A+  G   I++ L
Sbjct: 892  EAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 951

Query: 157  LTVCPGAW---KTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAI 213
            L    GA    +T SK+  +PL  AAM+GH  AVK+LL          +    TAL  A 
Sbjct: 952  LNA--GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1009

Query: 214  QCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRAT-S 272
              G  +V  LLLD   A +      G   L  AA  G  E  R L+ + G DV+     S
Sbjct: 1010 FQGRTEVVSLLLDRK-ANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK-GADVNAPPVPS 1067

Query: 273  THLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG-- 330
            +  TAL  AA +GH    + L+  GA I+ +++K  + L LA  G HL   + L+Q+G  
Sbjct: 1068 SRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1127

Query: 331  --LKDSEDITGTLA 342
                D+  IT  +A
Sbjct: 1128 VDAADNRKITPLMA 1141



 Score =  106 bits (264), Expect = 4e-23
 Identities = 92/294 (31%), Positives = 137/294 (46%), Gaps = 9/294 (3%)

Query: 38  DTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAV 97
           ++ L  A   GH +++ +L EA G D E    +    L EA   GH +  R LL  GA V
Sbjct: 402 ESALTLACYKGHLEMVRFLLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 460

Query: 98  DCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL 157
           +    +  +PL +A    ++ +   L+E GA+    N +G+     A+REG   ++  LL
Sbjct: 461 NMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL 520

Query: 158 TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
                      + + T L  A   G LE    L+K      D    C  T LM+A Q GH
Sbjct: 521 GQGANINAQTEETQETALTLACCGGFLEVADFLIKA---GADIELGCS-TPLMEAAQEGH 576

Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
           +++ + LL   GA + A  + G  AL  A   G  +    L+ + G D++  +     T 
Sbjct: 577 LELVKYLLAA-GANVHATTATGDTALTYACENGHTDVADVLL-QAGADLEHESEGGR-TP 633

Query: 278 LHYAAKEGHTSTIQTLLSLGADINSKDEKN-RSALHLACAGQHLACAKFLLQSG 330
           L  AA+ GH  T+Q L+S GA++N     N  + L LACAG HLA  + LL  G
Sbjct: 634 LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG 687



 Score =  102 bits (253), Expect = 7e-22
 Identities = 94/297 (31%), Positives = 143/297 (48%), Gaps = 10/297 (3%)

Query: 37   GDTLLHCAARHGHRDVLAYLAEAWGMDIEA-TNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
            G T L  AA  GH  V+  L +  G DIEA + R    PL  A S G ++ V  LL RGA
Sbjct: 865  GFTPLILAATAGHVGVVEILLDN-GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGA 923

Query: 96   AVDCLKKADWTPLMMACTRKNLGVIQELVEHGA--NPLLKNKDGWNSFHIASREGDPLIL 153
              +    +D+TPL +A +   + +I+ L+  GA  N    +K G +   +A+  G    +
Sbjct: 924  NKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAV 983

Query: 154  QYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAI 213
            + LL +           R T L  A   G  E V +LL R +   ++R   G+T LM+A 
Sbjct: 984  KLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDR-KANVEHRAKTGLTPLMEAA 1042

Query: 214  QCGHIDVARLLLDEHGACLSAE--DSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRAT 271
              G+ +V R+LLD+ GA ++A    S    AL  AA  G  +    L+   G  +DVR  
Sbjct: 1043 SGGYAEVGRVLLDK-GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR-GAHIDVRNK 1100

Query: 272  STHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQ 328
              + T L  AA  GH   +Q L+  GAD+++ D +  + L  A    H+   ++L++
Sbjct: 1101 KGN-TPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156



 Score =  100 bits (248), Expect = 3e-21
 Identities = 102/360 (28%), Positives = 158/360 (43%), Gaps = 40/360 (11%)

Query: 5   GDPRRLCRLVQEGRLRALKEEL--QAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGM 62
           GD   L      G ++ +K  L  +A        G+T L  A   G+ DV+  L E+ G 
Sbjct: 300 GDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES-GA 358

Query: 63  DIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDC-LKKADWTPLMMACTRKNLGVIQ 121
            IE  N +   PL EA S GH +  R LL  GA ++    +   + L +AC + +L +++
Sbjct: 359 SIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVR 418

Query: 122 ELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAW-KTESKIRRTPLHTAAM 180
            L+E GA+   K  +   +   A  +G   + + LL    GA     +    +PL  AA 
Sbjct: 419 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD--SGAQVNMPADSFESPLTLAAC 476

Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAE-DSLG 239
            GH+E   +L++R     +  D  G T LM+A + GH ++  LLL + GA ++A+ +   
Sbjct: 477 GGHVELAALLIERGASLEEVNDE-GYTPLMEAAREGHEEMVALLLGQ-GANINAQTEETQ 534

Query: 240 AQALHRAAVTGQDEAIRFLVSELGVDVDV-----------------------------RA 270
             AL  A   G  E   FL+ + G D+++                               
Sbjct: 535 ETALTLACCGGFLEVADFLI-KAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHAT 593

Query: 271 TSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
           T+T  TAL YA + GHT     LL  GAD+  + E  R+ L  A    H+   +FL+  G
Sbjct: 594 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKG 653



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 104/364 (28%), Positives = 151/364 (41%), Gaps = 51/364 (14%)

Query: 2   AQPGDPRRLCRLVQEG-RLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW 60
           A+ G    +  L+ +G  + A  EE Q          +T L  A   G  +V  +L +A 
Sbjct: 508 AREGHEEMVALLLGQGANINAQTEETQ----------ETALTLACCGGFLEVADFLIKA- 556

Query: 61  GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI 120
           G DIE        PL EAA  GH + V+YLL  GA V        T L  AC   +  V 
Sbjct: 557 GADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVA 613

Query: 121 QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM 180
             L++ GA+   +++ G      A+R G    +Q+L++      +T +    T L  A  
Sbjct: 614 DVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACA 673

Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
            GHL  V++LL     +P +R   G T L++A + GH  V   LLD     LSA      
Sbjct: 674 GGHLAVVELLLAH-GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVT 732

Query: 241 QA------LHRAAVTGQDEAIRFLVSELGVD----------------VDVRATSTHLTAL 278
           Q       L+RA      +A+  +V     D                V  RA++   T  
Sbjct: 733 QLTPPSHDLNRAPRV-PVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPT 791

Query: 279 HYAA---KEGHTSTIQTLLSLGA--------DINSKDEKNR-SALHLACAGQHLACAKFL 326
           H  A    +  T T   ++S  A        DI+++ E N  +AL LACAG H    + L
Sbjct: 792 HSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTL 851

Query: 327 LQSG 330
           L+ G
Sbjct: 852 LERG 855



 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 65/199 (32%), Positives = 96/199 (48%), Gaps = 16/199 (8%)

Query: 37   GDTLLHCAARHGHRDVLAYLAEAWGMDIEA---TNRDYKRPLHEAASMGHRDCVRYLLGR 93
            G + L  AA +GH   +  L +  G DI A   TNR+    L  A   G  + V  LL R
Sbjct: 967  GISPLMLAAMNGHTAAVKLLLDM-GSDINAQIETNRNTALTL--ACFQGRTEVVSLLLDR 1023

Query: 94   GAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGAN----PLLKNKDGWNSFHIASREGD 149
             A V+   K   TPLM A +     V + L++ GA+    P+  ++D   +  IA+ +G 
Sbjct: 1024 KANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD--TALTIAADKGH 1081

Query: 150  PLILQYLLTVCPGAW-KTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTA 208
                + L+    GA     +K   TPL  AA  GHL+ V++L++    + D  DN  +T 
Sbjct: 1082 YKFCELLIG--RGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ-AGADVDAADNRKITP 1138

Query: 209  LMDAIQCGHIDVARLLLDE 227
            LM A + GH+ V R L+ E
Sbjct: 1139 LMAAFRKGHVKVVRYLVKE 1157



 Score = 52.0 bits (123), Expect = 8e-07
 Identities = 26/67 (38%), Positives = 36/67 (53%)

Query: 264 VDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACA 323
           +D+D +  S H TAL  A   GH   +QTLL  GA I  +D+K  + L LA    H+   
Sbjct: 822 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 881

Query: 324 KFLLQSG 330
           + LL +G
Sbjct: 882 EILLDNG 888



 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 43/163 (26%), Positives = 78/163 (47%), Gaps = 4/163 (2%)

Query: 38   DTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAV 97
            +T L  A   G  +V++ L +    ++E   +    PL EAAS G+ +  R LL +GA V
Sbjct: 1002 NTALTLACFQGRTEVVSLLLDRKA-NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1060

Query: 98   DC--LKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
            +   +  +  T L +A  + +    + L+  GA+  ++NK G     +A+  G   ++Q 
Sbjct: 1061 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1120

Query: 156  LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEP 198
            L+         +++ + TPL  A   GH++ V+ L+K     P
Sbjct: 1121 LVQAGADVDAADNR-KITPLMAAFRKGHVKVVRYLVKEVNQFP 1162


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score =  106 bits (265), Expect = 3e-23
 Identities = 92/294 (31%), Positives = 136/294 (46%), Gaps = 9/294 (3%)

Query: 38  DTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAV 97
           ++ L  A   GH D++ +L EA G D E    +    L EA   GH +  R LL  GA V
Sbjct: 373 ESALTLACYKGHLDMVRFLLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 431

Query: 98  DCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL 157
           +    +  +PL +A    ++ +   L+E GAN    N +G+     A+REG   ++  LL
Sbjct: 432 NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 491

Query: 158 TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
                      + + T L  A   G  E    L+K      D    C  T LM+A Q GH
Sbjct: 492 AQGANINAQTEETQETALTLACCGGFSEVADFLIKA---GADIELGCS-TPLMEASQEGH 547

Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
           +++ + LL   GA + A  + G  AL  A   G  +    L+ + G D++  +     T 
Sbjct: 548 LELVKYLLAS-GANVHATTATGDTALTYACENGHTDVADVLL-QAGADLEHESEGGR-TP 604

Query: 278 LHYAAKEGHTSTIQTLLSLGADINSKDEKN-RSALHLACAGQHLACAKFLLQSG 330
           L  AA+ GH  T+Q L+S GA++N     N  + + LACAG HLA  + LL  G
Sbjct: 605 LMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658



 Score =  105 bits (263), Expect = 5e-23
 Identities = 96/327 (29%), Positives = 155/327 (47%), Gaps = 15/327 (4%)

Query: 5   GDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDI 64
           GD   + +L+ EGR  ++ E  +         G++LL  A   G+ ++   L        
Sbjct: 216 GDVNAVRKLLDEGR--SVNEHTEE--------GESLLCLACSAGYYELAQVLLAMHANVE 265

Query: 65  EATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELV 124
           +  N+    PL  A+S G+ D V+ LL   A V+       T L  AC    + +++ L+
Sbjct: 266 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325

Query: 125 EHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHL 184
             GAN    N++G      A+  G   + + LL    G     ++ + + L  A   GHL
Sbjct: 326 NEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 385

Query: 185 EAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALH 244
           + V+ LL+    + +++ +   TALM+A   GH++VARLLLD  GA ++         L 
Sbjct: 386 DMVRFLLE-AGADQEHKTDEMHTALMEACMDGHVEVARLLLDS-GAQVNMPADSFESPLT 443

Query: 245 RAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSK- 303
            AA  G  E    L+ E G +++        T L  AA+EGH   +  LL+ GA+IN++ 
Sbjct: 444 LAACGGHVELAALLI-ERGANLE-EVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501

Query: 304 DEKNRSALHLACAGQHLACAKFLLQSG 330
           +E   +AL LAC G     A FL+++G
Sbjct: 502 EETQETALTLACCGGFSEVADFLIKAG 528



 Score =  100 bits (248), Expect = 3e-21
 Identities = 95/326 (29%), Positives = 146/326 (44%), Gaps = 38/326 (11%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G+T L  A   G  D++  L    G +IE  N +   PL EAAS GH +  R LL  GA 
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNE-GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG 363

Query: 97  VDC-LKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
           ++    +   + L +AC + +L +++ L+E GA+   K  +   +   A  +G   + + 
Sbjct: 364 INTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423

Query: 156 LLTVCPGAW-KTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
           LL    GA     +    +PL  AA  GH+E   +L++R     +  D  G T LM+A +
Sbjct: 424 LLD--SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE-GYTPLMEAAR 480

Query: 215 CGHIDVARLLLDEHGACLSAE-DSLGAQALHRAAVTGQDEAIRFLVSELGVDVDV----- 268
            GH ++  LLL + GA ++A+ +     AL  A   G  E   FL+ + G D+++     
Sbjct: 481 EGHEEMVALLLAQ-GANINAQTEETQETALTLACCGGFSEVADFLI-KAGADIELGCSTP 538

Query: 269 ------------------------RATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKD 304
                                     T+T  TAL YA + GHT     LL  GAD+  + 
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598

Query: 305 EKNRSALHLACAGQHLACAKFLLQSG 330
           E  R+ L  A    HL   +FL+  G
Sbjct: 599 EGGRTPLMKAARAGHLCTVQFLISKG 624



 Score = 97.8 bits (242), Expect = 1e-20
 Identities = 95/306 (31%), Positives = 146/306 (47%), Gaps = 10/306 (3%)

Query: 37   GDTLLHCAARHGHRDVLAYLAEAWGMDIEA-TNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
            G T L  AA  GH  V+  L +  G DIEA + R    PL  A S G ++ V  LL RGA
Sbjct: 1088 GFTPLILAATAGHVGVVEILLDKGG-DIEAQSERTKDTPLSLACSGGRQEVVDLLLARGA 1146

Query: 96   AVDCLKKADWTPLMMACTRKNLGVIQELVEHGA--NPLLKNKDGWNSFHIASREGDPLIL 153
              +    +D+TPL +A +   + +I+ L+  GA  N    +K G +   +A+  G    +
Sbjct: 1147 NKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAV 1206

Query: 154  QYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAI 213
            + LL +           R T L  A   G  E V +LL R +   ++R   G+T LM+A 
Sbjct: 1207 KLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDR-KANVEHRAKTGLTPLMEAA 1265

Query: 214  QCGHIDVARLLLDEHGACLSAE--DSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRAT 271
              G+ +V R+LLD+ GA ++A    S    AL  AA  G  +    L+   G  +DVR  
Sbjct: 1266 SGGYAEVGRVLLDK-GADVNAPPVPSSRDTALTIAADKGHYKFCELLIHR-GAHIDVRNK 1323

Query: 272  STHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGL 331
              + T L  A+  GH   +Q L+  GAD+++ D +  + L  A    H+   ++L++   
Sbjct: 1324 KGN-TPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVN 1382

Query: 332  KDSEDI 337
            +   DI
Sbjct: 1383 QFPSDI 1388



 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 90/308 (29%), Positives = 138/308 (44%), Gaps = 43/308 (13%)

Query: 62   MDIEA-TNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI 120
            +DI+A T  ++   L  A + GH + V  L+ R A ++   K  +TPL++A T  ++GV+
Sbjct: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104

Query: 121  QELVE----------------------------------HGANPLLKNKDGWNSFHIASR 146
            + L++                                   GAN   +N   +    +A+ 
Sbjct: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164

Query: 147  EGDPLILQYLLTVCPGA---WKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDN 203
             G   I++ LL    GA    +T SK+  +PL  AAM+GH+ AVK+LL          + 
Sbjct: 1165 GGYVNIIKILLNA--GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIET 1222

Query: 204  CGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELG 263
               TAL  A   G  +V  LLLD   A +      G   L  AA  G  E  R L+ + G
Sbjct: 1223 NRNTALTLACFQGRAEVVSLLLDRK-ANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK-G 1280

Query: 264  VDVDV-RATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLAC 322
             DV+     S+  TAL  AA +GH    + L+  GA I+ +++K  + L LA  G H   
Sbjct: 1281 ADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDV 1340

Query: 323  AKFLLQSG 330
             + L+Q+G
Sbjct: 1341 VQLLVQAG 1348



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 65/229 (28%), Positives = 109/229 (47%), Gaps = 3/229 (1%)

Query: 102 KADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCP 161
           + D   L  AC+  ++  +++L++ G +     ++G +   +A   G   + Q LL +  
Sbjct: 203 QVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 262

Query: 162 GAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVA 221
                 +K   TPL  A+  G+L+ VK+LL     + + +   G TAL  A   G +D+ 
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLH-DADVNSQSATGNTALTYACAGGFVDIV 321

Query: 222 RLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYA 281
           ++LL+E GA +   +  G   L  AA  G  E  R L+   G  ++  +     +AL  A
Sbjct: 322 KVLLNE-GANIEDHNENGHTPLMEAASAGHVEVARVLLDH-GAGINTHSNEFKESALTLA 379

Query: 282 AKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
             +GH   ++ LL  GAD   K ++  +AL  AC   H+  A+ LL SG
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428



 Score = 79.3 bits (194), Expect = 5e-15
 Identities = 58/183 (31%), Positives = 88/183 (48%), Gaps = 18/183 (9%)

Query: 15  QEGRLRALKEELQAAGGCPGPA--GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYK 72
           QEG L  +K  L +          GDT L  A  +GH DV   L +A G D+E  +   +
Sbjct: 544 QEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA-GADLEHESEGGR 602

Query: 73  RPLHEAASMGHRDCVRYLLGRGAAVD-CLKKADWTPLMMACTRKNLGVIQELVEHGANPL 131
            PL +AA  GH   V++L+ +GA V+      D T + +AC   +L V++ L+ HGA+P 
Sbjct: 603 TPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPT 662

Query: 132 LKNKDGWNSFHIASREGDPLILQYLL--------------TVCPGAWKTESKIRRTPLHT 177
            + KDG      A++ G   ++ YLL              +  P   + +S++ R P HT
Sbjct: 663 HRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPTHT 722

Query: 178 AAM 180
            AM
Sbjct: 723 LAM 725



 Score = 72.0 bits (175), Expect = 8e-13
 Identities = 66/221 (29%), Positives = 97/221 (43%), Gaps = 15/221 (6%)

Query: 13  LVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYK 72
           L Q   + A  EE Q          +T L  A   G  +V  +L +A G DIE       
Sbjct: 491 LAQGANINAQTEETQ----------ETALTLACCGGFSEVADFLIKA-GADIEL---GCS 536

Query: 73  RPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLL 132
            PL EA+  GH + V+YLL  GA V        T L  AC   +  V   L++ GA+   
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596

Query: 133 KNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLK 192
           +++ G      A+R G    +Q+L++      +  +    T +  A   GHL  V++LL 
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656

Query: 193 RCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLS 233
               +P +R   G T L++A + GH +V   LLD     LS
Sbjct: 657 H-GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLS 696


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  106 bits (265), Expect = 3e-23
 Identities = 92/294 (31%), Positives = 136/294 (46%), Gaps = 9/294 (3%)

Query: 38  DTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAV 97
           ++ L  A   GH D++ +L EA G D E    +    L EA   GH +  R LL  GA V
Sbjct: 373 ESALTLACYKGHLDMVRFLLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 431

Query: 98  DCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL 157
           +    +  +PL +A    ++ +   L+E GAN    N +G+     A+REG   ++  LL
Sbjct: 432 NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 491

Query: 158 TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
                      + + T L  A   G  E    L+K      D    C  T LM+A Q GH
Sbjct: 492 AQGANINAQTEETQETALTLACCGGFSEVADFLIKA---GADIELGCS-TPLMEASQEGH 547

Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
           +++ + LL   GA + A  + G  AL  A   G  +    L+ + G D++  +     T 
Sbjct: 548 LELVKYLLAS-GANVHATTATGDTALTYACENGHTDVADVLL-QAGADLEHESEGGR-TP 604

Query: 278 LHYAAKEGHTSTIQTLLSLGADINSKDEKN-RSALHLACAGQHLACAKFLLQSG 330
           L  AA+ GH  T+Q L+S GA++N     N  + + LACAG HLA  + LL  G
Sbjct: 605 LMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658



 Score =  105 bits (263), Expect = 5e-23
 Identities = 96/327 (29%), Positives = 155/327 (47%), Gaps = 15/327 (4%)

Query: 5   GDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDI 64
           GD   + +L+ EGR  ++ E  +         G++LL  A   G+ ++   L        
Sbjct: 216 GDVNAVRKLLDEGR--SVNEHTEE--------GESLLCLACSAGYYELAQVLLAMHANVE 265

Query: 65  EATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELV 124
           +  N+    PL  A+S G+ D V+ LL   A V+       T L  AC    + +++ L+
Sbjct: 266 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325

Query: 125 EHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHL 184
             GAN    N++G      A+  G   + + LL    G     ++ + + L  A   GHL
Sbjct: 326 NEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 385

Query: 185 EAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALH 244
           + V+ LL+    + +++ +   TALM+A   GH++VARLLLD  GA ++         L 
Sbjct: 386 DMVRFLLE-AGADQEHKTDEMHTALMEACMDGHVEVARLLLDS-GAQVNMPADSFESPLT 443

Query: 245 RAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSK- 303
            AA  G  E    L+ E G +++        T L  AA+EGH   +  LL+ GA+IN++ 
Sbjct: 444 LAACGGHVELAALLI-ERGANLE-EVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501

Query: 304 DEKNRSALHLACAGQHLACAKFLLQSG 330
           +E   +AL LAC G     A FL+++G
Sbjct: 502 EETQETALTLACCGGFSEVADFLIKAG 528



 Score =  100 bits (248), Expect = 3e-21
 Identities = 95/326 (29%), Positives = 146/326 (44%), Gaps = 38/326 (11%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G+T L  A   G  D++  L    G +IE  N +   PL EAAS GH +  R LL  GA 
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNE-GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG 363

Query: 97  VDC-LKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
           ++    +   + L +AC + +L +++ L+E GA+   K  +   +   A  +G   + + 
Sbjct: 364 INTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423

Query: 156 LLTVCPGAW-KTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
           LL    GA     +    +PL  AA  GH+E   +L++R     +  D  G T LM+A +
Sbjct: 424 LLD--SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE-GYTPLMEAAR 480

Query: 215 CGHIDVARLLLDEHGACLSAE-DSLGAQALHRAAVTGQDEAIRFLVSELGVDVDV----- 268
            GH ++  LLL + GA ++A+ +     AL  A   G  E   FL+ + G D+++     
Sbjct: 481 EGHEEMVALLLAQ-GANINAQTEETQETALTLACCGGFSEVADFLI-KAGADIELGCSTP 538

Query: 269 ------------------------RATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKD 304
                                     T+T  TAL YA + GHT     LL  GAD+  + 
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598

Query: 305 EKNRSALHLACAGQHLACAKFLLQSG 330
           E  R+ L  A    HL   +FL+  G
Sbjct: 599 EGGRTPLMKAARAGHLCTVQFLISKG 624



 Score = 97.8 bits (242), Expect = 1e-20
 Identities = 95/306 (31%), Positives = 146/306 (47%), Gaps = 10/306 (3%)

Query: 37   GDTLLHCAARHGHRDVLAYLAEAWGMDIEA-TNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
            G T L  AA  GH  V+  L +  G DIEA + R    PL  A S G ++ V  LL RGA
Sbjct: 1088 GFTPLILAATAGHVGVVEILLDKGG-DIEAQSERTKDTPLSLACSGGRQEVVDLLLARGA 1146

Query: 96   AVDCLKKADWTPLMMACTRKNLGVIQELVEHGA--NPLLKNKDGWNSFHIASREGDPLIL 153
              +    +D+TPL +A +   + +I+ L+  GA  N    +K G +   +A+  G    +
Sbjct: 1147 NKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAV 1206

Query: 154  QYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAI 213
            + LL +           R T L  A   G  E V +LL R +   ++R   G+T LM+A 
Sbjct: 1207 KLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDR-KANVEHRAKTGLTPLMEAA 1265

Query: 214  QCGHIDVARLLLDEHGACLSAE--DSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRAT 271
              G+ +V R+LLD+ GA ++A    S    AL  AA  G  +    L+   G  +DVR  
Sbjct: 1266 SGGYAEVGRVLLDK-GADVNAPPVPSSRDTALTIAADKGHYKFCELLIHR-GAHIDVRNK 1323

Query: 272  STHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGL 331
              + T L  A+  GH   +Q L+  GAD+++ D +  + L  A    H+   ++L++   
Sbjct: 1324 KGN-TPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVN 1382

Query: 332  KDSEDI 337
            +   DI
Sbjct: 1383 QFPSDI 1388



 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 90/308 (29%), Positives = 138/308 (44%), Gaps = 43/308 (13%)

Query: 62   MDIEA-TNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI 120
            +DI+A T  ++   L  A + GH + V  L+ R A ++   K  +TPL++A T  ++GV+
Sbjct: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104

Query: 121  QELVE----------------------------------HGANPLLKNKDGWNSFHIASR 146
            + L++                                   GAN   +N   +    +A+ 
Sbjct: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164

Query: 147  EGDPLILQYLLTVCPGA---WKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDN 203
             G   I++ LL    GA    +T SK+  +PL  AAM+GH+ AVK+LL          + 
Sbjct: 1165 GGYVNIIKILLNA--GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIET 1222

Query: 204  CGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELG 263
               TAL  A   G  +V  LLLD   A +      G   L  AA  G  E  R L+ + G
Sbjct: 1223 NRNTALTLACFQGRAEVVSLLLDRK-ANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK-G 1280

Query: 264  VDVDV-RATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLAC 322
             DV+     S+  TAL  AA +GH    + L+  GA I+ +++K  + L LA  G H   
Sbjct: 1281 ADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDV 1340

Query: 323  AKFLLQSG 330
             + L+Q+G
Sbjct: 1341 VQLLVQAG 1348



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 65/229 (28%), Positives = 109/229 (47%), Gaps = 3/229 (1%)

Query: 102 KADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCP 161
           + D   L  AC+  ++  +++L++ G +     ++G +   +A   G   + Q LL +  
Sbjct: 203 QVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 262

Query: 162 GAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVA 221
                 +K   TPL  A+  G+L+ VK+LL     + + +   G TAL  A   G +D+ 
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLH-DADVNSQSATGNTALTYACAGGFVDIV 321

Query: 222 RLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYA 281
           ++LL+E GA +   +  G   L  AA  G  E  R L+   G  ++  +     +AL  A
Sbjct: 322 KVLLNE-GANIEDHNENGHTPLMEAASAGHVEVARVLLDH-GAGINTHSNEFKESALTLA 379

Query: 282 AKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
             +GH   ++ LL  GAD   K ++  +AL  AC   H+  A+ LL SG
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428



 Score = 79.3 bits (194), Expect = 5e-15
 Identities = 58/183 (31%), Positives = 88/183 (48%), Gaps = 18/183 (9%)

Query: 15  QEGRLRALKEELQAAGGCPGPA--GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYK 72
           QEG L  +K  L +          GDT L  A  +GH DV   L +A G D+E  +   +
Sbjct: 544 QEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA-GADLEHESEGGR 602

Query: 73  RPLHEAASMGHRDCVRYLLGRGAAVD-CLKKADWTPLMMACTRKNLGVIQELVEHGANPL 131
            PL +AA  GH   V++L+ +GA V+      D T + +AC   +L V++ L+ HGA+P 
Sbjct: 603 TPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPT 662

Query: 132 LKNKDGWNSFHIASREGDPLILQYLL--------------TVCPGAWKTESKIRRTPLHT 177
            + KDG      A++ G   ++ YLL              +  P   + +S++ R P HT
Sbjct: 663 HRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPTHT 722

Query: 178 AAM 180
            AM
Sbjct: 723 LAM 725



 Score = 72.0 bits (175), Expect = 8e-13
 Identities = 66/221 (29%), Positives = 97/221 (43%), Gaps = 15/221 (6%)

Query: 13  LVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYK 72
           L Q   + A  EE Q          +T L  A   G  +V  +L +A G DIE       
Sbjct: 491 LAQGANINAQTEETQ----------ETALTLACCGGFSEVADFLIKA-GADIEL---GCS 536

Query: 73  RPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLL 132
            PL EA+  GH + V+YLL  GA V        T L  AC   +  V   L++ GA+   
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596

Query: 133 KNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLK 192
           +++ G      A+R G    +Q+L++      +  +    T +  A   GHL  V++LL 
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656

Query: 193 RCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLS 233
               +P +R   G T L++A + GH +V   LLD     LS
Sbjct: 657 H-GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLS 696


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  106 bits (264), Expect = 4e-23
 Identities = 105/343 (30%), Positives = 147/343 (42%), Gaps = 28/343 (8%)

Query: 41  LHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCL 100
           LH AA  GH +VL  L  A G D+   +R     LH AA+ G  + V+YLL  GA +D  
Sbjct: 177 LHWAAFLGHLEVLKLLV-ARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEP 235

Query: 101 KKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVC 160
                T L +AC      V  ELV  GAN    N  G+   H+A+   +  +   LL   
Sbjct: 236 NAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNN 295

Query: 161 PGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDV 220
                 +SK  ++PLH AA+HG     ++L++    E D  D  G T L  A + GH  +
Sbjct: 296 GADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGS-EIDCADKFGNTPLHVAARYGHELL 354

Query: 221 ARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSE-----------------LG 263
              L+  +GA  +         LH A + G  +  R L+S                   G
Sbjct: 355 ISTLMT-NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAG 413

Query: 264 VDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACA 323
            D++    +   T LH AA  G+   +  LLS GAD+  +D+  R+ LH A A     CA
Sbjct: 414 FDINT-PDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCA 472

Query: 324 KFLLQSGLKDSE-DITG------TLAQQLPRRADVLQGSGHSA 359
             L+ +G   +E D  G        A    RRA+    S H A
Sbjct: 473 VTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDA 515



 Score =  101 bits (251), Expect = 1e-21
 Identities = 90/297 (30%), Positives = 133/297 (44%), Gaps = 13/297 (4%)

Query: 39  TLLHCAARHGHRDVLAYLAEAWGM-DIEATNRDY-KRPLHEAASMGHRDCVRYLLGRGAA 96
           T LH AA  GH D L  L ++    DI      Y + PL  A   GH DCV  LL +G+ 
Sbjct: 654 TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGST 713

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
            D       T L           +  L++H A  L ++  G    H+AS  G   +L+ L
Sbjct: 714 ADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTL 773

Query: 157 LTVCPGAWKTESKIRRT---PLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAI 213
           L         ++ +  +   P+H A+  GH + +++LL+   +   Y +    T L  A+
Sbjct: 774 LQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFS--YLEGNPFTPLHCAV 831

Query: 214 QCGHIDVARLLLDEHGA-CLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATS 272
                    +LL   GA  +++ D+ G   LH AA       +R L+       +V AT 
Sbjct: 832 INNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQH---QAEVNATD 888

Query: 273 -THLTALHYAAKEGHTSTIQTLLSLG-ADINSKDEKNRSALHLACAGQHLACAKFLL 327
            T  TAL  AA+ G T+ ++ LL  G AD+   DE   +ALHLAC+  H  CA  +L
Sbjct: 889 HTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMIL 945



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 87/293 (29%), Positives = 133/293 (45%), Gaps = 7/293 (2%)

Query: 39  TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
           T LH AA +        LA      +   +R  +  LH A   GH + V  LL +GA+++
Sbjct: 109 TPLHVAAANRATKCAEALAPLLS-SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLN 167

Query: 99  CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLT 158
              K +  PL  A    +L V++ LV  GA+   K++ G+   H A+  G   +++YLL 
Sbjct: 168 VCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR 227

Query: 159 VCPGAWKTE-SKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
           +  GA   E +    T LH A   G  +AV + L       +  ++ G T L  A    +
Sbjct: 228 M--GAEIDEPNAFGNTALHIACYLGQ-DAVAIELVNAGANVNQPNDKGFTPLHVAAVSTN 284

Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
             +   LL  +GA ++ +   G   LH AA+ G+    + L+   G ++D  A     T 
Sbjct: 285 GALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQN-GSEIDC-ADKFGNTP 342

Query: 278 LHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
           LH AA+ GH   I TL++ GAD   +   +   LHLA       C + LL SG
Sbjct: 343 LHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSG 395



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 100/321 (31%), Positives = 135/321 (42%), Gaps = 27/321 (8%)

Query: 17  GRLRALKEELQAAG---GCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKR 73
           G L  LK  L A G   GC    G  LLH AA  G  +V+ YL    G +I+  N     
Sbjct: 184 GHLEVLKL-LVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR-MGAEIDEPNAFGNT 241

Query: 74  PLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQE-LVEHGANPLL 132
            LH A  +G       L+  GA V+      +TPL +A    N  +  E LV +GA+   
Sbjct: 242 ALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNY 301

Query: 133 KNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLK 192
           ++K+G +  H+A+  G       +L           K   TPLH AA +GH   +  L+ 
Sbjct: 302 QSKEGKSPLHMAAIHG-RFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMT 360

Query: 193 RCQYEPDYRDNCGVTALMDAIQCGHIDVARLLL-------------DEH----GACLSAE 235
               +   R    +  L  A+  G  D  R LL             +EH    G  ++  
Sbjct: 361 N-GADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTP 419

Query: 236 DSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLS 295
           D+LG   LH AA  G  E +  L+S  G D+  R      T LHYAA  G      TL++
Sbjct: 420 DNLGRTCLHAAASGGNVECLNLLLSS-GADLR-RRDKFGRTPLHYAAANGSYQCAVTLVT 477

Query: 296 LGADINSKDEKNRSALHLACA 316
            GA +N  D K  S LH A A
Sbjct: 478 AGAGVNEADCKGCSPLHYAAA 498



 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 77/269 (28%), Positives = 129/269 (47%), Gaps = 6/269 (2%)

Query: 63  DIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQE 122
           +I   +++ + PLH AA +G    ++ LL  GA V+       TPL  A   +N  V+  
Sbjct: 33  NINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGL 92

Query: 123 LVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHG 182
           L+ H A+   ++K      H+A+        + L  +   +     +  R+ LH A   G
Sbjct: 93  LLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL-SSLNVADRSGRSALHHAVHSG 151

Query: 183 HLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQA 242
           HLE V +LL +     +  D      L  A   GH++V +LL+   GA L  +D  G   
Sbjct: 152 HLETVNLLLNK-GASLNVCDKKERQPLHWAAFLGHLEVLKLLV-ARGADLGCKDRKGYGL 209

Query: 243 LHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINS 302
           LH AA +GQ E +++L+  +G ++D    +   TALH A   G  +    L++ GA++N 
Sbjct: 210 LHTAAASGQIEVVKYLL-RMGAEID-EPNAFGNTALHIACYLGQDAVAIELVNAGANVNQ 267

Query: 303 KDEKNRSALHLACAGQHLA-CAKFLLQSG 330
            ++K  + LH+A    + A C + L+ +G
Sbjct: 268 PNDKGFTPLHVAAVSTNGALCLELLVNNG 296



 Score = 92.4 bits (228), Expect = 5e-19
 Identities = 84/293 (28%), Positives = 137/293 (46%), Gaps = 7/293 (2%)

Query: 39  TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
           T LH AA  G   +L  L  + G ++ A +  +  PLH AA+  +   +  LL   A V+
Sbjct: 43  TPLHAAAYVGDVPILQLLLMS-GANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVN 101

Query: 99  CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLT 158
              K   TPL +A   +     + L    ++  + ++ G ++ H A   G    +  LL 
Sbjct: 102 ARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLN 161

Query: 159 VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHI 218
               +     K  R PLH AA  GHLE +K+L+ R   +   +D  G   L  A   G I
Sbjct: 162 K-GASLNVCDKKERQPLHWAAFLGHLEVLKLLVAR-GADLGCKDRKGYGLLHTAAASGQI 219

Query: 219 DVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTAL 278
           +V + LL   GA +   ++ G  ALH A   GQD A+   +   G +V+ +      T L
Sbjct: 220 EVVKYLL-RMGAEIDEPNAFGNTALHIACYLGQD-AVAIELVNAGANVN-QPNDKGFTPL 276

Query: 279 HYAAKEGHTS-TIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
           H AA   + +  ++ L++ GAD+N + ++ +S LH+A        ++ L+Q+G
Sbjct: 277 HVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNG 329



 Score = 92.4 bits (228), Expect = 5e-19
 Identities = 82/279 (29%), Positives = 125/279 (44%), Gaps = 17/279 (6%)

Query: 61  GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWT----PLMMACTRKN 116
           G D    +R     +H AA+ G+R  +  LL    + +CL+  + T    PL +A    +
Sbjct: 540 GADPSLRDRQGYTAVHYAAAYGNRQNLELLLEM--SFNCLEDVESTIPVSPLHLAAYNGH 597

Query: 117 LGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLH 176
              ++ L E   N  +++  G  +  +A+  G    ++ L      A   E K + TPLH
Sbjct: 598 CEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLH 657

Query: 177 TAAMHGHLEAVKVLLKRCQYE--PDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSA 234
            AA  GH +++ +L+   +     D  D  G T LM AI  GH+D   LLL E G+   A
Sbjct: 658 AAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLL-EKGSTADA 716

Query: 235 EDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATS-THLTALHYAAKEGHTSTIQTL 293
            D  G  ALHR AVTG ++ +  L+     D  V        T +H A+  GHT+ ++TL
Sbjct: 717 ADLRGRTALHRGAVTGCEDCLAALLDH---DAFVLCRDFKGRTPIHLASACGHTAVLRTL 773

Query: 294 LSLGADIN----SKDEKNRSALHLACAGQHLACAKFLLQ 328
           L      +      D    S +H A    H  C + LL+
Sbjct: 774 LQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE 812



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 98/357 (27%), Positives = 143/357 (40%), Gaps = 55/357 (15%)

Query: 33  PGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAA-SMGHRDCVRYLL 91
           P   G+T LH A   G   V   L  A G ++   N     PLH AA S     C+  L+
Sbjct: 235 PNAFGNTALHIACYLGQDAVAIELVNA-GANVNQPNDKGFTPLHVAAVSTNGALCLELLV 293

Query: 92  GRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPL 151
             GA V+   K   +PL MA         Q L+++G+     +K G    H+A+R G  L
Sbjct: 294 NNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHEL 353

Query: 152 ILQYLLTVCPGAWKTESKIRRT-PLHTAAMHGHLEAVKVLLKRCQ--------------- 195
           ++  L+T   GA      I    PLH A + G  +  + LL   Q               
Sbjct: 354 LISTLMT--NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLS 411

Query: 196 --YEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDE 253
             ++ +  DN G T L  A   G+++   LLL   GA L   D  G   LH AA  G  +
Sbjct: 412 AGFDINTPDNLGRTCLHAAASGGNVECLNLLLSS-GADLRRRDKFGRTPLHYAAANGSYQ 470

Query: 254 -AIRFLVSELGVDVDVRATSTHLTALHYAAK-------EGHTST---------------- 289
            A+  + +  GV+    A     + LHYAA        E HT +                
Sbjct: 471 CAVTLVTAGAGVN---EADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRK 527

Query: 290 -----IQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDITGTL 341
                ++ LL  GAD + +D +  +A+H A A  +    + LL+      ED+  T+
Sbjct: 528 EAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTI 584



 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 90/318 (28%), Positives = 134/318 (42%), Gaps = 41/318 (12%)

Query: 37   GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
            G T L  A  +GH D +  L E  G   +A +   +  LH  A  G  DC+  LL   A 
Sbjct: 688  GQTPLMLAIMNGHVDCVHLLLEK-GSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAF 746

Query: 97   VDCLKKADWTPLMMACTRKNLGVIQELVEHG--ANPLLKNKD--GWNSFHIASREGDPLI 152
            V C      TP+ +A    +  V++ L++     +PL    D  G++  H AS  G    
Sbjct: 747  VLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDC 806

Query: 153  LQYLLTVCPGAW---------------------------------KTESKIRRTPLHTAA 179
            L+ LL   P ++                                  +     RTPLH AA
Sbjct: 807  LELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAA 866

Query: 180  MHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLG 239
               ++  +++LL+  Q E +  D+ G TALM A + G       LL    A L+  D   
Sbjct: 867  FADNVSGLRMLLQH-QAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENK 925

Query: 240  AQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA-LHYAAKEGHTSTIQTLLSLGA 298
              ALH A   G ++    +++E      + AT++ L   LH AA+ G  S +Q LLS GA
Sbjct: 926  NTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGA 985

Query: 299  DINSKDEKNRSALHLACA 316
             + + DE+  +   LACA
Sbjct: 986  TVLAVDEEGHTPA-LACA 1002



 Score = 85.5 bits (210), Expect = 7e-17
 Identities = 83/303 (27%), Positives = 120/303 (39%), Gaps = 9/303 (2%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G T L  A   G  + +  L       +    +    PLH AA+ GH D +  L+  G  
Sbjct: 618 GRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGER 677

Query: 97  VDCLKKAD---WTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLIL 153
            D     D    TPLM+A    ++  +  L+E G+     +  G  + H  +  G    L
Sbjct: 678 ADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCL 737

Query: 154 QYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYR---DNCGVTALM 210
             LL         + K  RTP+H A+  GH   ++ LL+            D  G + + 
Sbjct: 738 AALLDHDAFVLCRDFK-GRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMH 796

Query: 211 DAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRA 270
            A   GH D   LLL EH      E +     LH A +  QD     L+  LG  +    
Sbjct: 797 WASYTGHEDCLELLL-EHSPFSYLEGN-PFTPLHCAVINNQDSTTEMLLGALGAKIVNSR 854

Query: 271 TSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
            +   T LH AA   + S ++ LL   A++N+ D   R+AL  A      A  +FLL  G
Sbjct: 855 DAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG 914

Query: 331 LKD 333
             D
Sbjct: 915 KAD 917



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 75/257 (29%), Positives = 119/257 (46%), Gaps = 5/257 (1%)

Query: 74  PLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLK 133
           PL +A      + VR LL +   ++ L +   TPL  A    ++ ++Q L+  GAN   K
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70

Query: 134 NKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKR 193
           +       H A+   +  +L  LL           K+ +TPLH AA +   +  + L   
Sbjct: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADV-NARDKLWQTPLHVAAANRATKCAEALAPL 129

Query: 194 CQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDE 253
                +  D  G +AL  A+  GH++   LLL++ GA L+  D    Q LH AA  G  E
Sbjct: 130 LS-SLNVADRSGRSALHHAVHSGHLETVNLLLNK-GASLNVCDKKERQPLHWAAFLGHLE 187

Query: 254 AIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHL 313
            ++ LV+  G D+  +    +   LH AA  G    ++ LL +GA+I+  +    +ALH+
Sbjct: 188 VLKLLVAR-GADLGCKDRKGY-GLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHI 245

Query: 314 ACAGQHLACAKFLLQSG 330
           AC     A A  L+ +G
Sbjct: 246 ACYLGQDAVAIELVNAG 262



 Score = 72.8 bits (177), Expect = 5e-13
 Identities = 81/317 (25%), Positives = 123/317 (38%), Gaps = 27/317 (8%)

Query: 32  CPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLL 91
           C    G+T LH AAR+GH  +++ L    G D          PLH A   G  DC R LL
Sbjct: 334 CADKFGNTPLHVAARYGHELLISTLMTN-GADTARRGIHDMFPLHLAVLFGFSDCCRKLL 392

Query: 92  GRGAAVDCLKKAD------------------WTPLMMACTRKNLGVIQELVEHGANPLLK 133
             G     +                       T L  A +  N+  +  L+  GA+   +
Sbjct: 393 SSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRR 452

Query: 134 NKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKR 193
           +K G    H A+  G       L+T   G  + + K   +PLH AA      A     + 
Sbjct: 453 DKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCK-GCSPLHYAA------ASDTYRRA 505

Query: 194 CQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDE 253
             + P   D      L ++ +         LLD +GA  S  D  G  A+H AA  G  +
Sbjct: 506 EPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLD-NGADPSLRDRQGYTAVHYAAAYGNRQ 564

Query: 254 AIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHL 313
            +  L+      ++   ++  ++ LH AA  GH   ++TL     +++ +D K R+AL L
Sbjct: 565 NLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFL 624

Query: 314 ACAGQHLACAKFLLQSG 330
           A       C + L   G
Sbjct: 625 ATERGSTECVEVLTAHG 641



 Score = 72.0 bits (175), Expect = 8e-13
 Identities = 67/241 (27%), Positives = 108/241 (44%), Gaps = 15/241 (6%)

Query: 100 LKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTV 159
           L   D  PL+ A   +++  ++ L+    N  + +++     H A+  GD  ILQ LL  
Sbjct: 4   LSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMS 63

Query: 160 CPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCG-----VTALMDAIQ 214
                  +  +  TPLH AA   + + + +LL     + + RD        V A   A +
Sbjct: 64  GANV-NAKDTLWLTPLHRAAASRNEKVLGLLLAHSA-DVNARDKLWQTPLHVAAANRATK 121

Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
           C    +A LL     + L+  D  G  ALH A  +G  E +  L+++ G  ++V      
Sbjct: 122 CAEA-LAPLL-----SSLNVADRSGRSALHHAVHSGHLETVNLLLNK-GASLNV-CDKKE 173

Query: 275 LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDS 334
              LH+AA  GH   ++ L++ GAD+  KD K    LH A A   +   K+LL+ G +  
Sbjct: 174 RQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEID 233

Query: 335 E 335
           E
Sbjct: 234 E 234



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 3/114 (2%)

Query: 27  QAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDC 86
           QA        G T L  AA +G    + +L      D+   + +    LH A S GH  C
Sbjct: 881 QAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKC 940

Query: 87  VRYLLGRG---AAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDG 137
              +L        ++    A   PL +A       V+Q L+ HGA  L  +++G
Sbjct: 941 ALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEG 994



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 29/82 (35%), Positives = 38/82 (46%), Gaps = 2/82 (2%)

Query: 38   DTLLHCAARHGHRD-VLAYLAEAWGMD-IEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
            +T LH A   GH    L  LAE   +  I ATN   + PLH AA  G    V+ LL  GA
Sbjct: 926  NTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGA 985

Query: 96   AVDCLKKADWTPLMMACTRKNL 117
             V  + +   TP +     K++
Sbjct: 986  TVLAVDEEGHTPALACAPNKDV 1007


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score =  105 bits (263), Expect = 5e-23
 Identities = 96/327 (29%), Positives = 155/327 (47%), Gaps = 15/327 (4%)

Query: 5   GDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDI 64
           GD   + +L+ EGR  ++ E  +         G++LL  A   G+ ++   L        
Sbjct: 216 GDVNAVRKLLDEGR--SVNEHTEE--------GESLLCLACSAGYYELAQVLLAMHANVE 265

Query: 65  EATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELV 124
           +  N+    PL  A+S G+ D V+ LL   A V+       T L  AC    + +++ L+
Sbjct: 266 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325

Query: 125 EHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHL 184
             GAN    N++G      A+  G   + + LL    G     ++ + + L  A   GHL
Sbjct: 326 NEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 385

Query: 185 EAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALH 244
           + V+ LL+    + +++ +   TALM+A   GH++VARLLLD  GA ++         L 
Sbjct: 386 DMVRFLLE-AGADQEHKTDEMHTALMEACMDGHVEVARLLLDS-GAQVNMPADSFESPLT 443

Query: 245 RAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSK- 303
            AA  G  E    L+ E G +++        T L  AA+EGH   +  LL+ GA+IN++ 
Sbjct: 444 LAACGGHVELAALLI-ERGANLE-EVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501

Query: 304 DEKNRSALHLACAGQHLACAKFLLQSG 330
           +E   +AL LAC G     A FL+++G
Sbjct: 502 EETQETALTLACCGGFSEVADFLIKAG 528



 Score =  101 bits (252), Expect = 9e-22
 Identities = 94/306 (30%), Positives = 151/306 (49%), Gaps = 15/306 (4%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G+T L  A   G  D++  L    G +IE  N +   PL EAAS GH +  R LL  GA 
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNE-GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG 363

Query: 97  VDC-LKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
           ++    +   + L +AC + +L +++ L+E GA+   K  +   +   A  +G   + + 
Sbjct: 364 INTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423

Query: 156 LLTVCPGAW-KTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
           LL    GA     +    +PL  AA  GH+E   +L++R     +  D  G T LM+A +
Sbjct: 424 LLD--SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE-GYTPLMEAAR 480

Query: 215 CGHIDVARLLLDEHGACLSAE-DSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATST 273
            GH ++  LLL + GA ++A+ +     AL  A   G  E   FL+ + G D+++  +  
Sbjct: 481 EGHEEMVALLLAQ-GANINAQTEETQETALTLACCGGFSEVADFLI-KAGADIELGCS-- 536

Query: 274 HLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG--L 331
             T L  A++EGH   ++ LL+ GA++++      +AL  AC   H   A  LLQ+G  L
Sbjct: 537 --TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594

Query: 332 KDSEDI 337
              ED+
Sbjct: 595 DKQEDM 600



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 65/229 (28%), Positives = 109/229 (47%), Gaps = 3/229 (1%)

Query: 102 KADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCP 161
           + D   L  AC+  ++  +++L++ G +     ++G +   +A   G   + Q LL +  
Sbjct: 203 QVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 262

Query: 162 GAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVA 221
                 +K   TPL  A+  G+L+ VK+LL     + + +   G TAL  A   G +D+ 
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLH-DADVNSQSATGNTALTYACAGGFVDIV 321

Query: 222 RLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYA 281
           ++LL+E GA +   +  G   L  AA  G  E  R L+   G  ++  +     +AL  A
Sbjct: 322 KVLLNE-GANIEDHNENGHTPLMEAASAGHVEVARVLLDH-GAGINTHSNEFKESALTLA 379

Query: 282 AKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
             +GH   ++ LL  GAD   K ++  +AL  AC   H+  A+ LL SG
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
           [Homo sapiens]
          Length = 616

 Score =  105 bits (263), Expect = 5e-23
 Identities = 96/327 (29%), Positives = 155/327 (47%), Gaps = 15/327 (4%)

Query: 5   GDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDI 64
           GD   + +L+ EGR  ++ E  +         G++LL  A   G+ ++   L        
Sbjct: 205 GDVNAVRKLLDEGR--SVNEHTEE--------GESLLCLACSAGYYELAQVLLAMHANVE 254

Query: 65  EATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELV 124
           +  N+    PL  A+S G+ D V+ LL   A V+       T L  AC    + +++ L+
Sbjct: 255 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 314

Query: 125 EHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHL 184
             GAN    N++G      A+  G   + + LL    G     ++ + + L  A   GHL
Sbjct: 315 NEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 374

Query: 185 EAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALH 244
           + V+ LL+    + +++ +   TALM+A   GH++VARLLLD  GA ++         L 
Sbjct: 375 DMVRFLLE-AGADQEHKTDEMHTALMEACMDGHVEVARLLLDS-GAQVNMPADSFESPLT 432

Query: 245 RAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSK- 303
            AA  G  E    L+ E G +++        T L  AA+EGH   +  LL+ GA+IN++ 
Sbjct: 433 LAACGGHVELAALLI-ERGANLE-EVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 490

Query: 304 DEKNRSALHLACAGQHLACAKFLLQSG 330
           +E   +AL LAC G     A FL+++G
Sbjct: 491 EETQETALTLACCGGFSEVADFLIKAG 517



 Score =  101 bits (252), Expect = 9e-22
 Identities = 94/306 (30%), Positives = 151/306 (49%), Gaps = 15/306 (4%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           G+T L  A   G  D++  L    G +IE  N +   PL EAAS GH +  R LL  GA 
Sbjct: 294 GNTALTYACAGGFVDIVKVLLNE-GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG 352

Query: 97  VDC-LKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
           ++    +   + L +AC + +L +++ L+E GA+   K  +   +   A  +G   + + 
Sbjct: 353 INTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 412

Query: 156 LLTVCPGAW-KTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
           LL    GA     +    +PL  AA  GH+E   +L++R     +  D  G T LM+A +
Sbjct: 413 LLD--SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE-GYTPLMEAAR 469

Query: 215 CGHIDVARLLLDEHGACLSAE-DSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATST 273
            GH ++  LLL + GA ++A+ +     AL  A   G  E   FL+ + G D+++  +  
Sbjct: 470 EGHEEMVALLLAQ-GANINAQTEETQETALTLACCGGFSEVADFLI-KAGADIELGCS-- 525

Query: 274 HLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG--L 331
             T L  A++EGH   ++ LL+ GA++++      +AL  AC   H   A  LLQ+G  L
Sbjct: 526 --TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583

Query: 332 KDSEDI 337
              ED+
Sbjct: 584 DKQEDM 589



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 65/229 (28%), Positives = 109/229 (47%), Gaps = 3/229 (1%)

Query: 102 KADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCP 161
           + D   L  AC+  ++  +++L++ G +     ++G +   +A   G   + Q LL +  
Sbjct: 192 QVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 251

Query: 162 GAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVA 221
                 +K   TPL  A+  G+L+ VK+LL     + + +   G TAL  A   G +D+ 
Sbjct: 252 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLH-DADVNSQSATGNTALTYACAGGFVDIV 310

Query: 222 RLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYA 281
           ++LL+E GA +   +  G   L  AA  G  E  R L+   G  ++  +     +AL  A
Sbjct: 311 KVLLNE-GANIEDHNENGHTPLMEAASAGHVEVARVLLDH-GAGINTHSNEFKESALTLA 368

Query: 282 AKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
             +GH   ++ LL  GAD   K ++  +AL  AC   H+  A+ LL SG
Sbjct: 369 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 417


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  105 bits (261), Expect = 8e-23
 Identities = 102/355 (28%), Positives = 154/355 (43%), Gaps = 53/355 (14%)

Query: 5   GDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDI 64
           GD  R+ RLV    + A       AG    P     LH AA  G +DV+ +L +  G ++
Sbjct: 193 GDVSRVKRLVDAANVNAK----DMAGRKSSP-----LHFAAGFGRKDVVEHLLQM-GANV 242

Query: 65  EATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELV 124
            A +     PLH A S GH + V  LL +GA  +     ++TPL  A  +  + V   L+
Sbjct: 243 HARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 302

Query: 125 EHGANPLLKNKDGWNSFHI--------------------ASREGDPLILQYLLTVCPGAW 164
           +HGA+P ++N DG ++  +                    A+R G+   L  LLT      
Sbjct: 303 QHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNC 362

Query: 165 KTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLL 224
                 + TPLH AA +  +  V++LL+    +   +D  G+  L +A   GH +V  LL
Sbjct: 363 HASDGRKSTPLHLAAGYNRVRIVQLLLQH-GADVHAKDKGGLVPLHNACSYGHYEVTELL 421

Query: 225 LDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVD-----------VDVRATST 273
           L +HGAC++A D      LH AA   + E    L+S  G D           VD+  T  
Sbjct: 422 L-KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH-GADPTLVNCHGKSAVDMAPTPE 479

Query: 274 HLTALHY---------AAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQH 319
               L Y         AA+E   + ++  L+L      + + + +ALH A A  H
Sbjct: 480 LRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLH 534



 Score = 94.7 bits (234), Expect = 1e-19
 Identities = 92/282 (32%), Positives = 130/282 (46%), Gaps = 26/282 (9%)

Query: 39  TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
           T LH AA +    V+ YL    G D+ A ++    PLH A S GH +    L+  GA+V+
Sbjct: 686 TPLHFAAGYNRVSVVEYLLHH-GADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVN 744

Query: 99  CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLT 158
                 +TPL  A  +    + + L++HGA+P  KN+DG     +  +EGD  I   L  
Sbjct: 745 VADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTDIQDLLR- 802

Query: 159 VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEP-DYRDNCG--VTALMDAIQC 215
                           L  AA  G L  V+   K C  E  + RD  G   T L  A   
Sbjct: 803 ------------GDAALLDAAKKGCLARVQ---KLCTPENINCRDTQGRNSTPLHLAAGY 847

Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATST-H 274
            +++VA  LL EHGA ++A+D  G   LH AA  G  +    L+     +  V AT    
Sbjct: 848 NNLEVAEYLL-EHGADVNAQDKGGLIPLHNAASYGHVDIAALLIK---YNTCVNATDKWA 903

Query: 275 LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACA 316
            T LH AA++G T     LL+ GAD   K+++ ++ L LA A
Sbjct: 904 FTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945



 Score = 89.4 bits (220), Expect = 5e-18
 Identities = 97/364 (26%), Positives = 158/364 (43%), Gaps = 53/364 (14%)

Query: 16  EGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPL 75
           E +L AL   L            T LH AA +    ++  L +  G D+ A ++    PL
Sbjct: 348 EEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQH-GADVHAKDKGGLVPL 406

Query: 76  HEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNK 135
           H A S GH +    LL  GA V+ +    +TPL  A ++  + V   L+ HGA+P L N 
Sbjct: 407 HNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNC 466

Query: 136 DGWNSFHI---------------------ASREGDPLILQYLLTVCPGAWKTESKIRRTP 174
            G ++  +                     A+RE D   ++  L +    +K + +   T 
Sbjct: 467 HGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFK-QPQSHETA 525

Query: 175 LH--TAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACL 232
           LH   A++H   + V  LL R     + ++   +T L  A +  H DV   +L +HGA +
Sbjct: 526 LHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVME-VLHKHGAKM 584

Query: 233 SAEDSLGAQALHRAAVTGQDEAIRFLVS----------------ELGVDV--DVRATSTH 274
           +A D+LG  ALHRAA+ G  +  R L+S                ++G +    + + ST 
Sbjct: 585 NALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTP 644

Query: 275 LTA------LHYAAKEGHTSTIQTLLSLGADINSKDEKNR--SALHLACAGQHLACAKFL 326
           +        L  A+K G   T++ L S   ++N +D + R  + LH A     ++  ++L
Sbjct: 645 IRTSDVDYRLLEASKAGDLETVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYL 703

Query: 327 LQSG 330
           L  G
Sbjct: 704 LHHG 707



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 88/341 (25%), Positives = 142/341 (41%), Gaps = 51/341 (14%)

Query: 38  DTLLHCAAR--HGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +T LHCA    H  R  +  L    G ++   N+D+  PLH AA   H D +  L   GA
Sbjct: 523 ETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGA 582

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHI------------ 143
            ++ L     T L  A    +L   + L+ +G++P + +  G+ +  +            
Sbjct: 583 KMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSES 642

Query: 144 --------------ASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKV 189
                         AS+ GD   ++ L +      +       TPLH AA +  +  V+ 
Sbjct: 643 TPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEY 702

Query: 190 LLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVT 249
           LL     +   +D  G+  L +A   GH +VA LL+  HGA ++  D      LH AA  
Sbjct: 703 LLHHGA-DVHAKDKGGLVPLHNACSYGHYEVAELLV-RHGASVNVADLWKFTPLHEAAAK 760

Query: 250 GQDEAIRFLVSELGV------------------DVDVRATSTHLTALHYAAKEGHTSTIQ 291
           G+ E  + L+                       D D++       AL  AAK+G  + +Q
Sbjct: 761 GKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQ 820

Query: 292 TLLSLGADINSKDEKNRSA--LHLACAGQHLACAKFLLQSG 330
            L +   +IN +D + R++  LHLA    +L  A++LL+ G
Sbjct: 821 KLCT-PENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHG 860



 Score = 62.0 bits (149), Expect = 8e-10
 Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 1/109 (0%)

Query: 39  TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
           T LH AA + + +V  YL E  G D+ A ++    PLH AAS GH D    L+     V+
Sbjct: 839 TPLHLAAGYNNLEVAEYLLEH-GADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVN 897

Query: 99  CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASRE 147
              K  +TPL  A  +    +   L+ HGA+P +KN++G     +A+ +
Sbjct: 898 ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD 946



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 42/133 (31%), Positives = 65/133 (48%), Gaps = 9/133 (6%)

Query: 205 GVTALMDAIQ-----CGHIDVARLLLDEHGACLSAEDSLGAQA--LHRAAVTGQDEAIRF 257
           GV A+  A++     C + DV+R+      A ++A+D  G ++  LH AA  G+ + +  
Sbjct: 175 GVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEH 234

Query: 258 LVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAG 317
           L+ ++G +V  R     L  LH A   GH   +  LL  GAD N++D  N + LH A   
Sbjct: 235 LL-QMGANVHARDDGG-LIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIK 292

Query: 318 QHLACAKFLLQSG 330
             +     LLQ G
Sbjct: 293 GKIDVCIVLLQHG 305


>gi|10863929 ribonuclease L [Homo sapiens]
          Length = 741

 Score =  104 bits (259), Expect = 1e-22
 Identities = 86/261 (32%), Positives = 134/261 (51%), Gaps = 18/261 (6%)

Query: 85  DCVRYLLGRGAAVDCLKK-ADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHI 143
           D V+ LL  GA V+  ++   WTPL  A       +++ L+ HGA+P+L+ K+G   F +
Sbjct: 39  DLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFIL 98

Query: 144 ASREGDPLILQYLLTVCPGAWKTESKIRR-TPLHTAAMHGHLEAVKVLLKR--------- 193
           A+  G   +L+  L+   GA   E      T    AA++G ++A+K L KR         
Sbjct: 99  AAIAGSVKLLKLFLS--KGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRK 156

Query: 194 CQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQD- 252
            + + +     G TALMDA + GH++V ++LLDE GA ++A D++G  AL  A ++  D 
Sbjct: 157 TKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDS 216

Query: 253 --EAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSL-GADINSKDEKNRS 309
             EAI  L+ + G DV+VR      T L  A ++ H   +Q LL     +IN  D   ++
Sbjct: 217 DVEAITHLLLDHGADVNVRG-ERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKT 275

Query: 310 ALHLACAGQHLACAKFLLQSG 330
           AL LA   +    A+ L + G
Sbjct: 276 ALLLAVELKLKKIAELLCKRG 296



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 32/93 (34%), Positives = 45/93 (48%), Gaps = 4/93 (4%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEA-TNRDYKRPLHEAASMGHRD---CVRYLLG 92
           G T L  AA  GH +VL  L +  G D+ A  N      +H   S    D       LL 
Sbjct: 168 GATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLD 227

Query: 93  RGAAVDCLKKADWTPLMMACTRKNLGVIQELVE 125
            GA V+   +   TPL++A  +K+LG++Q L+E
Sbjct: 228 HGADVNVRGERGKTPLILAVEKKHLGLVQRLLE 260



 Score = 31.6 bits (70), Expect = 1.2
 Identities = 27/96 (28%), Positives = 41/96 (42%), Gaps = 7/96 (7%)

Query: 34  GPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGR 93
           G  G T L  A    H  ++  L E   ++I  T+ D K  L  A  +  +     L  R
Sbjct: 236 GERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKR 295

Query: 94  GAAVDCLKKADWTPLMMACTRK-NLGVIQELVEHGA 128
           GA+ DC        L+M   R  +  +++ L+ HGA
Sbjct: 296 GASTDC------GDLVMTARRNYDHSLVKVLLSHGA 325


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score = 99.8 bits (247), Expect = 3e-21
 Identities = 91/321 (28%), Positives = 140/321 (43%), Gaps = 44/321 (13%)

Query: 39  TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
           T LH AA  G +DV+ YL +  G +++A +     PLH A S GH + V  LL  GA  +
Sbjct: 60  TPLHFAAGFGRKDVVEYLLQN-GANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118

Query: 99  CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIA-------------- 144
                ++TPL  A  +  + V   L++HGA P ++N DG  +  +A              
Sbjct: 119 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKK 178

Query: 145 ------SREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEP 198
                 +R G+   +  LLT            + TPLH AA +  ++ V++LL+    + 
Sbjct: 179 DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQH-GADV 237

Query: 199 DYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFL 258
             +D   +  L +A   GH +V  LL+ +HGAC++A D      LH AA   + E    L
Sbjct: 238 HAKDKGDLVPLHNACSYGHYEVTELLV-KHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 296

Query: 259 VSELGVD-----------VDVRATSTHLTALHY---------AAKEGHTSTIQTLLSLGA 298
           +S  G D           +D+  T      L Y         AA+E   + I+  LSL  
Sbjct: 297 LS-YGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM 355

Query: 299 DINSKDEKNRSALHLACAGQH 319
                 + + +ALH A A  +
Sbjct: 356 VNFKHPQTHETALHCAAASPY 376



 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 72/242 (29%), Positives = 110/242 (45%), Gaps = 23/242 (9%)

Query: 39  TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
           T LH AA +    V+ YL +  G D+ A ++    PLH A S GH +    L+  GA V+
Sbjct: 528 TPLHFAAGYNRVSVVEYLLQH-GADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVN 586

Query: 99  CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIAS---------REGD 149
                 +TPL  A  +    + + L++HGA+P  KN+DG     +             GD
Sbjct: 587 VADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGD 646

Query: 150 PLILQYLLTVCPGAWKTESK-----------IRRTPLHTAAMHGHLEAVKVLLKRCQYEP 198
             +L      C    K  S               TPLH AA + +LE  + LL+    + 
Sbjct: 647 AALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQH-GADV 705

Query: 199 DYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFL 258
           + +D  G+  L +A   GH+DVA LL+ ++ AC++A D      LH AA  G+ +    L
Sbjct: 706 NAQDKGGLIPLHNAASYGHVDVAALLI-KYNACVNATDKWAFTPLHEAAQKGRTQLCALL 764

Query: 259 VS 260
           ++
Sbjct: 765 LA 766



 Score = 85.5 bits (210), Expect = 7e-17
 Identities = 87/341 (25%), Positives = 144/341 (42%), Gaps = 51/341 (14%)

Query: 38  DTLLHCAARHGH--RDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
           +T LHCAA   +  R  +  L    G +I    +++  PLH A+   H D V  ++   A
Sbjct: 365 ETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEA 424

Query: 96  AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHI------------ 143
            V+ L     T L  A    +L   + L+ +G +P + +  G+ +  +            
Sbjct: 425 KVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEG 484

Query: 144 --------------ASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKV 189
                         A++ GD   ++ L TV     +     + TPLH AA +  +  V+ 
Sbjct: 485 ISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544

Query: 190 LLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVT 249
           LL+    +   +D  G+  L +A   GH +VA LL+ +HGA ++  D      LH AA  
Sbjct: 545 LLQH-GADVHAKDKGGLVPLHNACSYGHYEVAELLV-KHGAVVNVADLWKFTPLHEAAAK 602

Query: 250 GQDEAIRFLVSE------------------LGVDVDVRATSTHLTALHYAAKEGHTSTIQ 291
           G+ E  + L+                       D D++       AL  AAK+G  + ++
Sbjct: 603 GKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVK 662

Query: 292 TLLSLGADINSKDEKNR--SALHLACAGQHLACAKFLLQSG 330
             LS   ++N +D + R  + LHLA    +L  A++LLQ G
Sbjct: 663 K-LSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHG 702



 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 84/323 (26%), Positives = 121/323 (37%), Gaps = 58/323 (17%)

Query: 28  AAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCV 87
           AA     PA   L   A R+G  + +  L     ++   T      PLH AA  G +D V
Sbjct: 16  AAAEAVEPAARELFE-ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVV 74

Query: 88  RYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASRE 147
            YLL  GA V         PL  AC+  +  V+  L+ HGA+P    +D WN        
Sbjct: 75  EYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADP--NARDNWNY------- 125

Query: 148 GDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVT 207
                                    TPLH AA+ G ++   VLL+    EP  R+  G T
Sbjct: 126 -------------------------TPLHEAAIKGKIDVCIVLLQHGA-EPTIRNTDGRT 159

Query: 208 AL--------------------MDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAA 247
           AL                    +++ + G+ +    LL        A D   +  LH AA
Sbjct: 160 ALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAA 219

Query: 248 VTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKN 307
              + + ++ L+   G DV  +     L  LH A   GH    + L+  GA +N+ D   
Sbjct: 220 GYNRVKIVQLLLQH-GADVHAKDKGD-LVPLHNACSYGHYEVTELLVKHGACVNAMDLWQ 277

Query: 308 RSALHLACAGQHLACAKFLLQSG 330
            + LH A +   +     LL  G
Sbjct: 278 FTPLHEAASKNRVEVCSLLLSYG 300



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 89/300 (29%), Positives = 125/300 (41%), Gaps = 38/300 (12%)

Query: 44  AARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKA 103
           AA+ G  + +  L     ++          PLH AA       V YLL  GA V    K 
Sbjct: 499 AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKG 558

Query: 104 DWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGA 163
              PL  AC+  +  V + LV+HGA   + +   +   H A+ +G   I + LL    GA
Sbjct: 559 GLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQ--HGA 616

Query: 164 WKT-ESKIRRTPLH--------------------TAAMHGHLEAVKVLLKRCQYEPD--- 199
             T +++   TPL                      AA  G L  VK L       PD   
Sbjct: 617 DPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL-----SSPDNVN 671

Query: 200 YRDNCG--VTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRF 257
            RD  G   T L  A    +++VA  LL +HGA ++A+D  G   LH AA  G  +    
Sbjct: 672 CRDTQGRHSTPLHLAAGYNNLEVAEYLL-QHGADVNAQDKGGLIPLHNAASYGHVDVAAL 730

Query: 258 LVSELGVDVDVRATST-HLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACA 316
           L+     +  V AT     T LH AA++G T     LL+ GAD   K+++ ++ L L  A
Sbjct: 731 LIK---YNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787



 Score = 62.8 bits (151), Expect = 5e-10
 Identities = 38/109 (34%), Positives = 56/109 (51%), Gaps = 1/109 (0%)

Query: 39  TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
           T LH AA + + +V  YL +  G D+ A ++    PLH AAS GH D    L+   A V+
Sbjct: 681 TPLHLAAGYNNLEVAEYLLQH-GADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVN 739

Query: 99  CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASRE 147
              K  +TPL  A  +    +   L+ HGA+P LKN++G     + S +
Sbjct: 740 ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSAD 788



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 62/252 (24%), Positives = 102/252 (40%), Gaps = 31/252 (12%)

Query: 37  GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
           GD  L  AA+ G    +  L+    ++   T   +  PLH AA   + +   YLL  GA 
Sbjct: 645 GDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGAD 704

Query: 97  VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
           V+   K    PL  A +  ++ V   L+++ A     +K  +   H A+++G   +   L
Sbjct: 705 VNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALL 764

Query: 157 LTVCPGAWKT-ESKIRRTPLHTAAMHGHLEAVKVLLKRCQ--------YEPDYRDNC--- 204
           L    GA  T +++  +TPL   +     + V  LL            Y+P   +     
Sbjct: 765 L--AHGADPTLKNQEGQTPLDLVS----ADDVSALLTAAMPPSALPSCYKPQVLNGVRSP 818

Query: 205 GVTALMDAIQCG-----------HIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDE 253
           G TA  DA+  G            +D       E  + +S+  + GA +L +  V G D 
Sbjct: 819 GATA--DALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDF 876

Query: 254 AIRFLVSELGVD 265
           +I   V  LG++
Sbjct: 877 SITQFVRNLGLE 888



 Score = 42.0 bits (97), Expect = 9e-04
 Identities = 32/104 (30%), Positives = 47/104 (45%), Gaps = 4/104 (3%)

Query: 230 ACLSAEDSL---GAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGH 286
           AC SA        A+ L  A   G  E ++ LV+   V+    A     T LH+AA  G 
Sbjct: 12  ACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTA-GRKSTPLHFAAGFGR 70

Query: 287 TSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
              ++ LL  GA++ ++D+     LH AC+  H      LL+ G
Sbjct: 71  KDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHG 114


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.134    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,507,931
Number of Sequences: 37866
Number of extensions: 637423
Number of successful extensions: 6804
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 356
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 1389
Number of HSP's gapped (non-prelim): 2103
length of query: 361
length of database: 18,247,518
effective HSP length: 104
effective length of query: 257
effective length of database: 14,309,454
effective search space: 3677529678
effective search space used: 3677529678
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.