Search of human proteins with 5803106

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5803106 myotilin isoform a [Homo sapiens]
         (498 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5803106 myotilin isoform a [Homo sapiens]                          999   0.0  
gi|209693444 myotilin isoform b [Homo sapiens]                        630   0.0  
gi|153792294 myopalladin [Homo sapiens]                               248   7e-66
gi|93102361 palladin [Homo sapiens]                                   243   3e-64
gi|110349721 titin isoform novex-3 [Homo sapiens]                     127   2e-29
gi|110349719 titin isoform N2-A [Homo sapiens]                        127   2e-29
gi|110349717 titin isoform novex-2 [Homo sapiens]                     127   2e-29
gi|110349713 titin isoform novex-1 [Homo sapiens]                     127   2e-29
gi|110349715 titin isoform N2-B [Homo sapiens]                        127   2e-29
gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]       95   1e-19
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]        95   1e-19
gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens]       95   1e-19
gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]        95   1e-19
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact...    91   2e-18
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac...    91   2e-18
gi|118572606 hemicentin 1 [Homo sapiens]                               91   3e-18
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor...    86   6e-17
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo...    85   1e-16
gi|126517478 peroxidasin homolog-like [Homo sapiens]                   85   2e-16
gi|109150416 peroxidasin [Homo sapiens]                                84   3e-16
gi|222352127 sidekick 2 [Homo sapiens]                                 82   1e-15
gi|169217528 PREDICTED: similar to sidekick homolog 2 (chicken) ...    82   1e-15
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...    82   1e-15
gi|209862903 leucine-rich repeats and immunoglobulin-like domain...    82   1e-15
gi|19743806 roundabout 1 isoform b [Homo sapiens]                      81   2e-15
gi|4506569 roundabout 1 isoform a [Homo sapiens]                       81   2e-15
gi|224994173 roundabout 1 isoform d [Homo sapiens]                     81   3e-15
gi|224994171 roundabout 1 isoform c [Homo sapiens]                     81   3e-15
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ...    81   3e-15
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ...    81   3e-15

>gi|5803106 myotilin isoform a [Homo sapiens]
          Length = 498

 Score =  999 bits (2582), Expect = 0.0
 Identities = 498/498 (100%), Positives = 498/498 (100%)

Query: 1   MFNYERPKHFIQSQNPCGSRLQPPGPETSSFSSQTKQSSIIIQPRQCTEQRFSASSTLSS 60
           MFNYERPKHFIQSQNPCGSRLQPPGPETSSFSSQTKQSSIIIQPRQCTEQRFSASSTLSS
Sbjct: 1   MFNYERPKHFIQSQNPCGSRLQPPGPETSSFSSQTKQSSIIIQPRQCTEQRFSASSTLSS 60

Query: 61  HITMSSSAFPASPQQHAGSNPGQRVTTTYNQSPASFLSSILPSQPDYNSSKIPSAMDSNY 120
           HITMSSSAFPASPQQHAGSNPGQRVTTTYNQSPASFLSSILPSQPDYNSSKIPSAMDSNY
Sbjct: 61  HITMSSSAFPASPQQHAGSNPGQRVTTTYNQSPASFLSSILPSQPDYNSSKIPSAMDSNY 120

Query: 121 QQSSAGQPINAKPSQTANAKPIPRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQRLT 180
           QQSSAGQPINAKPSQTANAKPIPRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQRLT
Sbjct: 121 QQSSAGQPINAKPSQTANAKPIPRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQRLT 180

Query: 181 YEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQ 240
           YEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQ
Sbjct: 181 YEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQ 240

Query: 241 DAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIV 300
           DAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIV
Sbjct: 241 DAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIV 300

Query: 301 SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKV 360
           SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKV
Sbjct: 301 SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKV 360

Query: 361 LEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGW 420
           LEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGW
Sbjct: 361 LEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGW 420

Query: 421 YTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNPE 480
           YTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNPE
Sbjct: 421 YTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNPE 480

Query: 481 GEFQRLAAQSGLYESEEL 498
           GEFQRLAAQSGLYESEEL
Sbjct: 481 GEFQRLAAQSGLYESEEL 498


>gi|209693444 myotilin isoform b [Homo sapiens]
          Length = 314

 Score =  630 bits (1625), Expect = 0.0
 Identities = 314/314 (100%), Positives = 314/314 (100%)

Query: 185 MARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQ 244
           MARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQ
Sbjct: 1   MARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQ 60

Query: 245 EKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG 304
           EKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG
Sbjct: 61  EKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG 120

Query: 305 LHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGD 364
           LHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGD
Sbjct: 121 LHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGD 180

Query: 365 SVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVS 424
           SVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVS
Sbjct: 181 SVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVS 240

Query: 425 AVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNPEGEFQ 484
           AVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNPEGEFQ
Sbjct: 241 AVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNPEGEFQ 300

Query: 485 RLAAQSGLYESEEL 498
           RLAAQSGLYESEEL
Sbjct: 301 RLAAQSGLYESEEL 314


>gi|153792294 myopalladin [Homo sapiens]
          Length = 1320

 Score =  248 bits (634), Expect = 7e-66
 Identities = 130/311 (41%), Positives = 192/311 (61%), Gaps = 17/311 (5%)

Query: 203  DDSG-----AQDSQQHNSEHARLQVPTSQVRSRSTSRGDVN---------DQDAIQEKFY 248
            DD G     A + Q   S    L V +  +RSR TS G  +         D++ +QE+F+
Sbjct: 1012 DDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFF 1071

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
             P F+Q P +M   EGR CR+D KVSGLP P+++W LNG+ V  D  HKM+V E G+HSL
Sbjct: 1072 RPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSL 1131

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
            + + +   DAG Y C+A N+ G+ +F+++L V+AKE K+AP+ + K Q+  V EG  V+L
Sbjct: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            EC++  +PPP  +WK++NE +    +RIS++QD TG   LLI+   K DAGWYT+SA NE
Sbjct: 1192 ECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251

Query: 429  AGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNP-EGEFQRLA 487
            AG+ +C  RLD+ A+ +  +P P  + VRP+ S+Y +L  KGL++  AF+  E       
Sbjct: 1252 AGIVSCTARLDIYAQWHHQIPPP--MSVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSC 1309

Query: 488  AQSGLYESEEL 498
            +   + ES+EL
Sbjct: 1310 SSRSVVESDEL 1320



 Score =  100 bits (250), Expect = 2e-21
 Identities = 110/498 (22%), Positives = 190/498 (38%), Gaps = 93/498 (18%)

Query: 2    FNYERPKHFIQSQNPCGSRLQPPGPETSSFSSQTKQSSIIIQPRQCTEQRFSASSTLSSH 61
            F+  RPK+F  S N   + + P      + SS  +     +          S  +     
Sbjct: 718  FSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGG 777

Query: 62   ITMSSSAFPASPQQHAGS-----------------NPGQRVTTTYNQSPASFLSSILPSQ 104
            +++ +   P  P +                     +P     T+  Q+P +FLSS+LPS 
Sbjct: 778  LSIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSL 837

Query: 105  PDY---NSSKIPSAMDSNYQQSSAGQPINAKPSQTANAKPIPRTPDHEIQGSKEALIQDL 161
            P     N+  +P +  S   Q  A +  N K  Q  N        D  I+ +K A+I+DL
Sbjct: 838  PAIPPTNAMGLPRSAPSMPSQGLAKK--NTKSPQPVN--------DDNIRETKNAVIRDL 887

Query: 162  ERKLKCKDTLLHNGNQRLT-YEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARL 220
             +K+   D   +    +++ +E+++   +        V ++ D+       QH+      
Sbjct: 888  GKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEI------QHD------ 935

Query: 221  QVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPD 280
            ++PT                     K   P F +  ++  + EG       K+ G+P P 
Sbjct: 936  EIPTG--------------------KCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPK 975

Query: 281  VSWYLNGRTVQSDDLH-KMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLD 339
            V W+ +G+ +   + H KM     G  SL  E   + D G Y  +A N  G  + +  L 
Sbjct: 976  VYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLM 1035

Query: 340  VLA----------------------------KEHKRAPMFIYKPQSKKVLEGDSVKLECQ 371
            V +                            +E    P F+  P      EG   +L+C+
Sbjct: 1036 VQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCK 1095

Query: 372  ISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGV 431
            +S +PPP+L W  N + V  +     L ++ TG  +LLI  + ++DAG Y   A N+ G 
Sbjct: 1096 VSGLPPPELTWLLNGQPVLPDASHKMLVRE-TGVHSLLIDPLTQRDAGTYKCIATNKTGQ 1154

Query: 432  TTCNTRLDVTARPNQTLP 449
             + +  L V A+  +  P
Sbjct: 1155 NSFSLELSVVAKEVKKAP 1172



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 43/170 (25%), Positives = 72/170 (42%), Gaps = 4/170 (2%)

Query: 211 QQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKF-YPPRFIQVPENMSIDEGRFCRM 269
           +Q  ++    +   S+     T+ G        +E    PPRF Q   +  + EG   ++
Sbjct: 229 EQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQL 288

Query: 270 DFKVSGLPAPDVSWYLNGRTVQ-SDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNR 328
           D  V G+P P V WY  G+ ++ S D+H  IV    LHSL        D G Y+C A N 
Sbjct: 289 DCIVVGIPPPQVRWYCEGKELENSPDIH--IVQAGNLHSLTIAEAFEEDTGRYSCFASNI 346

Query: 329 AGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPP 378
            G  + + ++ +       +     K +  ++ + + V      SA+ PP
Sbjct: 347 YGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPP 396



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 29/102 (28%), Positives = 49/102 (48%), Gaps = 7/102 (6%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQ-SDDLH------KMIVSE 302
           P F ++ +N+S  EG+    + +V G P+P V WY  G  ++ S D        + +   
Sbjct: 435 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 494

Query: 303 KGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKE 344
           + + +L+   V A D+G + C A N+ G  +   QL V   E
Sbjct: 495 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 31/107 (28%), Positives = 51/107 (47%), Gaps = 8/107 (7%)

Query: 348 APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV- 406
           AP+F    Q+    EG  V  EC++   P PK+ W R   +++ + D   L +       
Sbjct: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 493

Query: 407 -----TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTL 448
                TL+I +V  +D+G +T +A N+ G  +   +L V  R N+ L
Sbjct: 494 PEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV--RGNEDL 538



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 25/90 (27%), Positives = 46/90 (51%), Gaps = 2/90 (2%)

Query: 349 PMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTL 408
           P F  K +S++V EG  V+L+C +  IPPP++ W    + ++ + D   +   N   +T 
Sbjct: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT- 327

Query: 409 LIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 438
            I +  ++D G Y+  A N  G  + +  +
Sbjct: 328 -IAEAFEEDTGRYSCFASNIYGTDSTSAEI 356


>gi|93102361 palladin [Homo sapiens]
          Length = 1106

 Score =  243 bits (620), Expect = 3e-64
 Identities = 110/213 (51%), Positives = 155/213 (72%)

Query: 228  RSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNG 287
            R RS SR   ++ + IQE+F+ P F+Q P ++++ EG+ CRMD KVSGLP PD+SW L+G
Sbjct: 889  RPRSRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDG 948

Query: 288  RTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKR 347
            + V+ D  HKM+V E G+HSLI E V + DAG Y C+A NRAG+ +F+++L V AKE  +
Sbjct: 949  KPVRPDSAHKMLVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHK 1008

Query: 348  APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
             P+FI K Q+  V +G  V+LEC++  +PPP++FWK+ NE +  +TDR+S++QDN G + 
Sbjct: 1009 PPVFIEKLQNTGVADGYPVRLECRVLGVPPPQIFWKKENESLTHSTDRVSMHQDNHGYIC 1068

Query: 408  LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
            LLI+   K+DAGWYTVSA NEAG+ +C  RLDV
Sbjct: 1069 LLIQGATKEDAGWYTVSAKNEAGIVSCTARLDV 1101



 Score =  132 bits (332), Expect = 7e-31
 Identities = 136/474 (28%), Positives = 203/474 (42%), Gaps = 64/474 (13%)

Query: 12   QSQNPCGSRLQPPGP--ETSSFSSQTKQSSIIIQPRQCTEQRFSASSTLSSHITMSSSAF 69
            +S N       PP P  ETSS    +K+ S I Q           +  L          F
Sbjct: 553  ESNNDHFQHFPPPPPILETSSLELASKKPSEIQQVN---------NPELGLSRAALQMQF 603

Query: 70   PASPQQHAGSNPGQRVTTTYNQSPASFLSSILPSQPDYNSSKIPSAMDSNYQQSSAGQPI 129
             A+ ++  G +P + V    N    S  S   P+     + + P  +     +   G P 
Sbjct: 604  NAAERETNGVHPSRGVNGLINGKANSNKSLPTPAVLLSPTKEPPPLL----AKPKLGFP- 658

Query: 130  NAKPSQTANAKPIPRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQRLTYEEKMARRL 189
              K S+TA         D EIQG+K+A+IQDLERKL+ K+ LL+NG  RLTYEE+MARRL
Sbjct: 659  -KKASRTARI-----ASDEEIQGTKDAVIQDLERKLRFKEDLLNNGQPRLTYEERMARRL 712

Query: 190  LGPQNAAAVFQAQDDSGAQDSQQH--NSEHARL--QVPTSQVRSRSTSRGD-VNDQDAIQ 244
            LG  ++A VF  Q+      +Q++  +S   RL  ++     RS     GD V   D   
Sbjct: 713  LG-ADSATVFNIQEPEEETANQEYKVSSCEQRLISEIEYRLERSPVDESGDEVQYGDVPV 771

Query: 245  EKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSE-K 303
            E    P F    ++  I EG       +V+G P P + W+ +G+ +     H  I  +  
Sbjct: 772  ENGMAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLD 831

Query: 304  GLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLA--------------------- 342
            G  SL        D G Y  +A N  G  + T +L V A                     
Sbjct: 832  GTCSLHTTASTLDDDGNYTIMAANPQGRISCTGRLMVQAVNQRGRSPRSPSGHPHVRRPR 891

Query: 343  -------------KEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMV 389
                         +E    P F+  P    V EG   +++C++S +P P L W+ + + V
Sbjct: 892  SRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPV 951

Query: 390  QFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTAR 443
            + ++    L ++N G  +L+I+ V  +DAG YT  A N AG  + +  L V A+
Sbjct: 952  RPDSAHKMLVREN-GVHSLIIEPVTSRDAGIYTCIATNRAGQNSFSLELVVAAK 1004



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 103/517 (19%), Positives = 178/517 (34%), Gaps = 131/517 (25%)

Query: 27  ETSSFSSQTKQSSII-IQPRQCTEQRFSASSTLSSHITMSSSAFPASPQQHAGSNPGQRV 85
           ET  F S+ + S I    P    E      + L  H +       ++P Q       + +
Sbjct: 54  ETEDFDSEKEISQIFSTSPASLCEHPSHKETKLGEHASRRPQDNRSTPVQPLAEKQTKSI 113

Query: 86  TTTYNQSPASFLSSILPSQPDY---------NSSKIPSA-MDSNYQQSSAGQPINAKPSQ 135
           ++  ++   +   S L ++P Y           +K PS  +         G P +    +
Sbjct: 114 SSPVSKRKPAM--SPLLTRPSYIRSLRKAEKRGAKTPSTNVKPKTPHQRKGGPQSQLCDK 171

Query: 136 TAN-----------AKPIPRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQRLTYEEK 184
            AN           AKP  R+P+ E        +    +       LL     +   E++
Sbjct: 172 AANLIEELTSIFKAAKPRNRSPNGESSSPDSGYLSPKNQP----SALLSASASQSPMEDQ 227

Query: 185 --MARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDA 242
             M R +  P         QD +   + + H   H+ L  P +                 
Sbjct: 228 GEMEREVKSPGARHCYQDNQDLAVPHNRKSHPQPHSALHFPAA----------------- 270

Query: 243 IQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTV----------QS 292
                  PRFIQ   +  + EG    ++ +V+G P P V W+  G+ +          + 
Sbjct: 271 -------PRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGKELHNTPDIQIHCEG 323

Query: 293 DDLHKMIVSEK-----GLHSLI---------------FEVVRASDAGAYACVAKNRAG-- 330
            DLH +I++E      G ++ +                E   ++D+ + +   K+RAG  
Sbjct: 324 GDLHTLIIAEAFEDDTGRYTCLATNPSGSDTTSAEVFIEGASSTDSDSESLAFKSRAGAM 383

Query: 331 ----EATFTVQLDVLAKEHKRA-----------------------------------PMF 351
               + T +V L + +   K                                     P+F
Sbjct: 384 PQAQKKTTSVSLTIGSSSPKTGVTTAVIQPLSVPVQQVHSPTSYLCRPDGTTTAYFPPVF 443

Query: 352 IYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV----- 406
             + Q+  V EG  V LEC++   PP ++ W R    +Q + D   L +           
Sbjct: 444 TKELQNTAVAEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAEPEEI 503

Query: 407 -TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTA 442
            TL+I +   +DAG +T SA N+ G  T   +L VT+
Sbjct: 504 CTLVIAETFPEDAGIFTCSARNDYGSATSTAQLVVTS 540



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 47/194 (24%), Positives = 81/194 (41%), Gaps = 24/194 (12%)

Query: 220 LQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAP 279
           L VP  QV S ++    +   D     ++PP F +  +N ++ EG+   ++ +V G P  
Sbjct: 414 LSVPVQQVHSPTSY---LCRPDGTTTAYFPPVFTKELQNTAVAEGQVVVLECRVRGAPPL 470

Query: 280 DVSWYLNGRTVQSDDLHKMI-------VSEKGLHSLIFEVVRASDAGAYACVAKNRAGEA 332
            V W+  G  +Q     +++          + + +L+       DAG + C A+N  G A
Sbjct: 471 QVQWFRQGSEIQDSPDFRILQKKPRSTAEPEEICTLVIAETFPEDAGIFTCSARNDYGSA 530

Query: 333 TFTVQLDVLAKEHKRAPM----------FIYKPQSKKVLEGDSVKL----ECQISAIPPP 378
           T T QL V +   +              F + P    +LE  S++L      +I  +  P
Sbjct: 531 TSTAQLVVTSANTENCSYESMGESNNDHFQHFPPPPPILETSSLELASKKPSEIQQVNNP 590

Query: 379 KLFWKRNNEMVQFN 392
           +L   R    +QFN
Sbjct: 591 ELGLSRAALQMQFN 604



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 33/105 (31%), Positives = 49/105 (46%), Gaps = 1/105 (0%)

Query: 242  AIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTV-QSDDLHKMIV 300
            A +E   PP FI+  +N  + +G   R++ +V G+P P + W     ++  S D   M  
Sbjct: 1002 AAKEAHKPPVFIEKLQNTGVADGYPVRLECRVLGVPPPQIFWKKENESLTHSTDRVSMHQ 1061

Query: 301  SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEH 345
               G   L+ +     DAG Y   AKN AG  + T +LDV    H
Sbjct: 1062 DNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDVYISRH 1106


>gi|110349721 titin isoform novex-3 [Homo sapiens]
          Length = 5604

 Score =  127 bits (320), Expect = 2e-29
 Identities = 66/216 (30%), Positives = 115/216 (53%)

Query: 245  EKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG 304
            E+ Y P F+  P +    EG+  R D KV G P P+  W+ +G+ + +D  HK+++ E G
Sbjct: 1452 ERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDG 1511

Query: 305  LHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGD 364
              SLI      SD+G +  VA+NRAG ++ +V L V A EH+  PMF+ K ++  + EG 
Sbjct: 1512 TQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGS 1571

Query: 365  SVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVS 424
             ++++ + +  P P + W +N++++  +       +   G   L I     +D+ WYT +
Sbjct: 1572 RLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTAT 1631

Query: 425  AVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTF 460
            A+N+AG  T   +++V     +  P  K +  R T+
Sbjct: 1632 AINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTY 1667



 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 62/213 (29%), Positives = 109/213 (51%), Gaps = 13/213 (6%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVS-EKGLHSL 308
           P F Q  +++ + EG     +  +SG P P+VSW+ +G+ + +  L  + +S   G   L
Sbjct: 6   PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65

Query: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
               V  +++G Y+  A N +G+AT T +L  L K     P F+ + QS  V +G  V+L
Sbjct: 66  TIPAVTKANSGRYSLKATNGSGQATSTAEL--LVKAETAPPNFVQRLQSMTVRQGSQVRL 123

Query: 369 ECQISAIPPPKLFWKRNNEMVQFNTD-RISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
           + +++ IP P + + R+   +Q + D +IS   D     +LLI +   +D+G Y+V+A N
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGD---LYSLLIAEAYPEDSGTYSVNATN 180

Query: 428 EAGVTTCNTRL------DVTARPNQTLPAPKQL 454
             G  T    L      +V A+  +T+ +  Q+
Sbjct: 181 SVGRATSTAELLVQGEEEVPAKKTKTIVSTAQI 213



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 60/231 (25%), Positives = 94/231 (40%), Gaps = 42/231 (18%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP  +   +N+++ EG    ++  +SG P+P V+WY     ++S  +   I  + G+  L
Sbjct: 942  PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESS-IDFQITFQSGIARL 1000

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDV----------------LAKEHKR----- 347
            +     A D+G + C A N AG  + +  L V                   E KR     
Sbjct: 1001 MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESR 1060

Query: 348  --------------------APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNE 387
                                AP FI KP  +K++EG SV   CQ+   P P ++WK++  
Sbjct: 1061 DVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGV 1120

Query: 388  MVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 438
             +         Y   TG   L+I      DAG YT+   N+ G T+ +  L
Sbjct: 1121 PLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 61/228 (26%), Positives = 90/228 (39%), Gaps = 37/228 (16%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PPRFI    +  I E         V G+P P+V WY     ++ D++  +I  EKG H+L
Sbjct: 5379 PPRFIMPICDFKIPENSDAVFKCSVIGIPTPEVKWYKEYMCIEPDNIKYVISEEKGSHTL 5438

Query: 309  IFEVVRASDAGAYACVAKNRAGEAT---FTVQLD-----VLAKEHK-------------- 346
                V  SD+  Y C A N  GEA    F    D     V+AK+ K              
Sbjct: 5439 KIRNVCLSDSATYRCRAVNCVGEAICRGFLTMGDSEIFAVIAKKSKVTLSSLMEELVLKS 5498

Query: 347  -------------RAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNT 393
                           P FI          G +   +C +   P P ++W ++ ++VQ   
Sbjct: 5499 NYTDSFFEFQVVEGPPRFIKGISDCYAPIGTAAYFQCLVRGSPRPTVYWYKDGKLVQGR- 5557

Query: 394  DRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVT 441
             R ++ +  TG   L I  + K D G Y   A N++G+      L +T
Sbjct: 5558 -RFTVEESGTGFHNLFITSLVKSDEGEYRCVATNKSGMAESFAALTLT 5604



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 39/126 (30%), Positives = 64/126 (50%), Gaps = 1/126 (0%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
           PP F+Q  ++M++ +G   R+  +V+G+P P V +Y +G  +QS  L   I  E  L+SL
Sbjct: 103 PPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQS-SLDFQISQEGDLYSL 161

Query: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
           +       D+G Y+  A N  G AT T +L V  +E   A        + ++ E    ++
Sbjct: 162 LIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRI 221

Query: 369 ECQISA 374
           E +I A
Sbjct: 222 EKKIEA 227



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 52/214 (24%), Positives = 90/214 (42%), Gaps = 20/214 (9%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP+ +Q  + +++  G+  R    +SG P P +SWY   + + +    K +   +    L
Sbjct: 3238 PPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLL 3297

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKE--HKRAPMFIYKP------QSKKV 360
            + E     DA  Y C AKN  G AT +  L V   E       M +Y P      Q    
Sbjct: 3298 LIEAF-PEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVT 3356

Query: 361  LEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGW 420
             EG   + +C++S       ++ ++ ++      R++ ++D      L I +   +D G 
Sbjct: 3357 SEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDT---YQLEIAEAYPEDEGT 3413

Query: 421  YTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQL 454
            YT  A N  G         V++  N +L AP+ +
Sbjct: 3414 YTFVASNAVG--------QVSSTANLSLEAPESI 3439



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 52/176 (29%), Positives = 78/176 (44%), Gaps = 16/176 (9%)

Query: 280  DVSWYLNGRTV--QSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQ 337
            D  WY +G  +  Q  + HK +V E+ +H +     R SDAG Y  V    AG    +V 
Sbjct: 3176 DAHWYKDGIEINFQVQERHKYVV-ERRIHRMFISETRQSDAGEYTFV----AGRNRSSVT 3230

Query: 338  LDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRIS 397
            L V A E    P  + + Q   V  G   +    IS  P PK+ W +  +++  +T    
Sbjct: 3231 LYVNAPE---PPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLL--STGFKC 3285

Query: 398  LYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV----TARPNQTLP 449
             +  +    TLL+ +   +DA  YT  A N+ GV T +  L V       P+Q +P
Sbjct: 3286 KFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMP 3341



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 36/117 (30%), Positives = 59/117 (50%), Gaps = 2/117 (1%)

Query: 324  VAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWK 383
            V   R  + T T ++    +     P  +   ++  V+EG+SV LEC IS  P P + W 
Sbjct: 918  VLHGREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWY 977

Query: 384  RNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
            R +  ++ + D    +Q    R  L+I++   +D+G +T SAVNEAG  + +  L V
Sbjct: 978  REDYQIESSIDFQITFQSGIAR--LMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV 1032



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 62/264 (23%), Positives = 108/264 (40%), Gaps = 44/264 (16%)

Query: 235  GDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD 294
            GD+ D++  Q+ F+  +   +           CR+     G P   V W  +G+ +++ +
Sbjct: 1692 GDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLT--PIGDPTMVVEWLHDGKPLEAAN 1749

Query: 295  LHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAG----EATFTV-------------- 336
              +MI +E G  SL + V  + D+G   C A N+ G     AT  V              
Sbjct: 1750 RLRMI-NEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPE 1808

Query: 337  ---------QLDVLAKE-----------HKRAPMFIYKPQSKKVLEGDSVKLECQISAIP 376
                     +L+ +A E            K+ P  +  P+  +VLEG++ +  C+++  P
Sbjct: 1809 GRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYP 1868

Query: 377  PPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
             PK+ W  N ++++  + R  +  D  G   L I D    D G   V+A N  GV     
Sbjct: 1869 QPKVNWYLNGQLIR-KSKRFRVRYD--GIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKV 1925

Query: 437  RLDVTARPNQTLPAPKQLRVRPTF 460
            +L++  R +      +    RP F
Sbjct: 1926 KLEIQQREDFRSVLRRAPEPRPEF 1949



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 35/102 (34%), Positives = 50/102 (49%), Gaps = 3/102 (2%)

Query: 347 RAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV 406
           +AP F    QS  VLEG +   E  IS  P P++ W R+ +++  +T        + GR 
Sbjct: 4   QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63

Query: 407 TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV---TARPN 445
            L I  V K ++G Y++ A N +G  T    L V   TA PN
Sbjct: 64  KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPN 105



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 38/158 (24%), Positives = 66/158 (41%), Gaps = 4/158 (2%)

Query: 191  GPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPP 250
            G  + +A    +D+    +  Q       LQ    +   R    G +      Q++   P
Sbjct: 1784 GTDHTSATLIVKDEKSLVEESQLPEGRKGLQ--RIEELERMAHEGALTGVTTDQKEKQKP 1841

Query: 251  RFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
              +  PE + + EG   R   +V+G P P V+WYLNG+ ++     +  V   G+H L  
Sbjct: 1842 DIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKS--KRFRVRYDGIHYLDI 1899

Query: 311  EVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRA 348
               ++ D G     A+N  G     V+L++  +E  R+
Sbjct: 1900 VDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRS 1937



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 48/162 (29%), Positives = 72/162 (44%), Gaps = 11/162 (6%)

Query: 277  PAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTV 336
            P   V WY +G  V   D ++M  S++ +H L    +  SDA  Y+CV        T T 
Sbjct: 2201 PFVKVKWYKDGMEVHEGDKYRMH-SDRKVHFLSILTIDTSDAEDYSCVLVEDENVKT-TA 2258

Query: 337  QLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRI 396
            +L V          F+ + Q  +V E  S +LEC +S   P  +  K  +  V+  ++  
Sbjct: 2259 KLIV----EGAVVEFVKELQDIEVPESYSGELECIVS---PENIEGKWYHNDVELKSNGK 2311

Query: 397  SLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 438
                   GR  L +KDV K+D G Y  S V +   TTC  ++
Sbjct: 2312 YTITSRRGRQNLTVKDVTKEDQGEY--SFVIDGKKTTCKLKM 2351



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 1/117 (0%)

Query: 230  RSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRT 289
            RS S G  N+    ++   PP FI+      + E        +V GLP P V WY N   
Sbjct: 5163 RSDSFGTPNEAIEPKDNEMPPSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSL 5222

Query: 290  VQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHK 346
            ++ D+  KM      + SL    ++  + G Y C A N  GEA     +D++ +E +
Sbjct: 5223 LEPDERIKM-ERVGNVCSLEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQEER 5278



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 34/117 (29%), Positives = 55/117 (47%), Gaps = 5/117 (4%)

Query: 236  DVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDL 295
            D+++ +A++  F   R     +N  I EG       K+SG P P ++WY +G+ ++  + 
Sbjct: 1282 DISESEAVESGF-DSRI----KNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGER 1336

Query: 296  HKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFI 352
            ++M   + G  SL   VV   D G Y   A N  G A  + +L V       AP +I
Sbjct: 1337 YQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYI 1393



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 4/90 (4%)

Query: 355  PQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVN 414
            P+  +  EGDS+ LEC IS  P P + W +N  +++ N  +    + N     L IKDVN
Sbjct: 4165 PKHARCREGDSIILECLISGEPQPVVTWFQNGVLLKQN-QKFQFEEVNCSH-QLYIKDVN 4222

Query: 415  KKDAGWYTVSAVNEAGVTTCNTRLDVTARP 444
             +D+G Y   A N +G     +  D+T  P
Sbjct: 4223 SQDSGKYKCVAENNSGAV--ESVSDLTVEP 4250



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 62/269 (23%), Positives = 101/269 (37%), Gaps = 46/269 (17%)

Query: 166  KCKDTLLHNGNQRLTYEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTS 225
            K KD LLH   + LT EEK A                            +E  ++ +PT 
Sbjct: 2033 KTKDELLH-WTKELTEEEKKAL---------------------------AEEGKITIPTF 2064

Query: 226  QVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYL 285
            +            D+  +      P+  +  ++ ++ +G       +V G P P+  WY 
Sbjct: 2065 KP-----------DKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYK 2113

Query: 286  NGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEH 345
            NG  ++  D       E  +  L+   V A D+ +    A N AGE +    L V AK+ 
Sbjct: 2114 NGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQ- 2172

Query: 346  KRAPMFIYKPQSKKVLEGDSV-KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTG 404
                 F  + Q     E D++   EC+ S  P  K+ W ++  M     D+  ++ D   
Sbjct: 2173 --LITFTQELQDVVAKEKDTMATFECETSE-PFVKVKWYKDG-MEVHEGDKYRMHSDRKV 2228

Query: 405  RVTLLIKDVNKKDAGWYTVSAVNEAGVTT 433
               L I  ++  DA  Y+   V +  V T
Sbjct: 2229 HF-LSILTIDTSDAEDYSCVLVEDENVKT 2256



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 32/114 (28%), Positives = 56/114 (49%), Gaps = 3/114 (2%)

Query: 359  KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
            ++LEG  V   C++S  P PK+ W ++ + ++ + +R  +     GR +L I  V  +D 
Sbjct: 1301 RILEGMGVTFHCKMSGYPLPKIAWYKDGKRIK-HGERYQMDFLQDGRASLRIPVVLPEDE 1359

Query: 419  GWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLN 472
            G YT  A N  G   C+ +L V   P   L AP  +      S+  +L+ + ++
Sbjct: 1360 GIYTAFASNIKGNAICSGKLYV--EPAAPLGAPTYIPTLEPVSRIRSLSPRSVS 1411



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 56/234 (23%), Positives = 89/234 (38%), Gaps = 39/234 (16%)

Query: 149  EIQGSKEALIQDLERKLKCKDTLLHNGNQ--RLTYEEKMARRLLG--------------- 191
            EI+ S+EAL+++   K      +L N N   R   EE MA   +G               
Sbjct: 3805 EIRMSQEALVKESLPKDHLYGEILVNENTQARGQLEEIMANTTIGESSTYITNVCEKEEV 3864

Query: 192  ---PQNAAAVF--QAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEK 246
               P+N +      A +  G   + + + E A  ++    +R    S     D+   ++K
Sbjct: 3865 YETPENVSQAITPHASESFGTLVNVEESEEIASERIKKDDLRELQLSASTRIDEFKTEQK 3924

Query: 247  -----FY-----------PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTV 290
                 F+           PP F+Q  E+  + EG  C       G P P V+WY N   +
Sbjct: 3925 EENMRFFENSFRKRPQRCPPSFLQEIESQEVYEGDSCNFVCHFQGYPQPIVTWYNNDMPI 3984

Query: 291  QSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKE 344
              +  + +I S +    L    V   + G+  CV  N+ G    T  L V AK+
Sbjct: 3985 PRNQ-NFIIHSLENYSILTLSSVHHQNEGSITCVLFNQYGTVKTTSMLKVKAKQ 4037



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 28/84 (33%), Positives = 41/84 (48%), Gaps = 2/84 (2%)

Query: 349  PMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGR--V 406
            P F  K   K VLEG+ V   C++ A P P++ W  NN  +     RI   + +      
Sbjct: 3504 PSFTQKLTFKYVLEGEPVVFTCRLIACPTPEMTWFHNNRPIPTGLRRIIKAESDLHHHSS 3563

Query: 407  TLLIKDVNKKDAGWYTVSAVNEAG 430
            +L IK V  +D+G Y + A+N  G
Sbjct: 3564 SLEIKRVQDRDSGSYRLLAINSEG 3587



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 42/141 (29%), Positives = 74/141 (52%), Gaps = 14/141 (9%)

Query: 283  WYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLA 342
            WY N   ++S+  +  I S +G  +L  + V   D G Y+ V   +  + T  +++    
Sbjct: 2299 WYHNDVELKSNGKYT-ITSRRGRQNLTVKDVTKEDQGEYSFVIDGK--KTTCKLKM---- 2351

Query: 343  KEHKRAPMFIYKPQS-KKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQD 401
               K  P+ I +  S +KV EGD V+LE ++S +   +  W ++ + VQ  +DR+ +  D
Sbjct: 2352 ---KPRPIAILQGLSDQKVCEGDIVQLEVKVS-LESVEGVWMKDGQEVQ-PSDRVHIVID 2406

Query: 402  NTGRVTLLIKDVNKKDAGWYT 422
                + LLI+D+ K+DAG Y+
Sbjct: 2407 KQSHM-LLIEDMTKEDAGNYS 2426



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 41/178 (23%), Positives = 79/178 (44%), Gaps = 15/178 (8%)

Query: 251  RFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
            + I+ P++++  E      +  VS    P V W+     ++  D H++ VSE+ +H L+ 
Sbjct: 2796 KIIKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKSVEIKPSDKHRL-VSERKVHKLML 2853

Query: 311  EVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLEC 370
            + +  SDAG Y  V      +A   V+   + K  K     I  P++K      +   EC
Sbjct: 2854 QNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKN----IEVPETK------TASFEC 2903

Query: 371  QISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            ++S    P + W +N   ++ +     + Q    +  L+I + + +D+  YT    N+
Sbjct: 2904 EVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQ--LIIMNTSTEDSAEYTFVCGND 2958



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 29/94 (30%), Positives = 47/94 (50%), Gaps = 4/94 (4%)

Query: 249  PPRFIQ-VPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGL-H 306
            PP+ +Q +P++    EG    ++  +SG P P V+W+ NG  ++ +   K    E    H
Sbjct: 4157 PPKMLQEMPKHARCREGDSIILECLISGEPQPVVTWFQNGVLLKQNQ--KFQFEEVNCSH 4214

Query: 307  SLIFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
             L  + V + D+G Y CVA+N +G       L V
Sbjct: 4215 QLYIKDVNSQDSGKYKCVAENNSGAVESVSDLTV 4248



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 49/180 (27%), Positives = 84/180 (46%), Gaps = 25/180 (13%)

Query: 250  PRFIQVPENMS---IDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQ-SDDLHKMIVSEKGL 305
            PR I + + +S   + EG   +++ KVS L + +  W  +G+ VQ SD +H  IV +K  
Sbjct: 2353 PRPIAILQGLSDQKVCEGDIVQLEVKVS-LESVEGVWMKDGQEVQPSDRVH--IVIDKQS 2409

Query: 306  HSLIFEVVRASDAGAYA----CVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL 361
            H L+ E +   DAG Y+     +  + +G  +    +DV+       P+     +   V+
Sbjct: 2410 HMLLIEDMTKEDAGNYSFTIPALGLSTSGRVS-VYSVDVIT------PL-----KDVNVI 2457

Query: 362  EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWY 421
            EG    LEC++S      + W  N+E ++   DR+      T +  L+I   +  D G Y
Sbjct: 2458 EGTKAVLECKVSVPDVTSVKWYLNDEQIK-PDDRVQAIVKGT-KQRLVINRTHASDEGPY 2515



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 65/244 (26%), Positives = 94/244 (38%), Gaps = 33/244 (13%)

Query: 127  QPINAKPSQTAN-AKPIPRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQRLTYEEKM 185
            QP+  +  + A     I   P  +I   KE   Q L    KCK   LH+G +   Y   +
Sbjct: 3246 QPVTVQSGKPARFCAVISGRPQPKISWYKEE--QLLSTGFKCK--FLHDGQE---YTLLL 3298

Query: 186  ARRLLGPQNAAA-VFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQ 244
                  P++AA    +A++D G   +       A L V   +V S         DQ+   
Sbjct: 3299 IEAF--PEDAAVYTCEAKNDYGVATTS------ASLSVEVPEVVSP--------DQEM-- 3340

Query: 245  EKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG 304
               YPP  I   ++    EG+  R   +VSG     VSWY   + ++     +M   E  
Sbjct: 3341 -PVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQFEDT 3398

Query: 305  LHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKE---HKRAPMFIYKPQSKKVL 361
                I E     D G Y  VA N  G+ + T  L + A E   H+R    I     +   
Sbjct: 3399 YQLEIAEAY-PEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKELFS 3457

Query: 362  EGDS 365
            EG+S
Sbjct: 3458 EGES 3461



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 28/96 (29%), Positives = 46/96 (47%), Gaps = 1/96 (1%)

Query: 348  APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
            AP    + QS+ V +G       ++   P P+  W +N   ++  +DRI  Y        
Sbjct: 2077 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIE-RSDRIYWYWPEDNVCE 2135

Query: 408  LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTAR 443
            L+I+DV  +D+    V A+N AG T+ +  L V A+
Sbjct: 2136 LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAK 2171



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 32/116 (27%), Positives = 50/116 (43%), Gaps = 6/116 (5%)

Query: 349  PMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTL 408
            P F+ + +S++V EGDS    C     P P + W  N+  +  N + I    +N   +TL
Sbjct: 3944 PSFLQEIESQEVYEGDSCNFVCHFQGYPQPIVTWYNNDMPIPRNQNFIIHSLENYSILTL 4003

Query: 409  LIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYL 464
                V+ ++ G  T    N+ G     + L V A+    + A K     P F  YL
Sbjct: 4004 --SSVHHQNEGSITCVLFNQYGTVKTTSMLKVKAKQKHDVKAHKV----PVFHDYL 4053



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 43/183 (23%), Positives = 80/183 (43%), Gaps = 19/183 (10%)

Query: 165  LKCKDTLLHNGNQRLTYEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPT 224
            L+  +++LH   +R+  E +M  + L  +  +    ++ D+    S   + +H  +    
Sbjct: 3433 LEAPESILH---ERIEQEIEMEMKELFSEGESE--HSERDTRDAFSDSEDIDHKSMAAKR 3487

Query: 225  SQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWY 284
               R  STS            +++ P F Q      + EG       ++   P P+++W+
Sbjct: 3488 YASRISSTSSWP---------EYFKPSFTQKLTFKYVLEGEPVVFTCRLIACPTPEMTWF 3538

Query: 285  LNGRTVQSDDLHKMIVSEKGLH----SLIFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
             N R + +  L ++I +E  LH    SL  + V+  D+G+Y  +A N  G A  T  L V
Sbjct: 3539 HNNRPIPT-GLRRIIKAESDLHHHSSSLEIKRVQDRDSGSYRLLAINSEGSAESTASLLV 3597

Query: 341  LAK 343
            + K
Sbjct: 3598 IQK 3600



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 27/110 (24%), Positives = 52/110 (47%), Gaps = 4/110 (3%)

Query: 343  KEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDN 402
            K+++  P FI     +KV E  ++    ++  +P P + W RN  +++   +RI +  + 
Sbjct: 5177 KDNEMPPSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLE-PDERIKM--ER 5233

Query: 403  TGRV-TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAP 451
             G V +L I ++ K + G Y   AVN  G       +D+  +  + +  P
Sbjct: 5234 VGNVCSLEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQEERVVALP 5283



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 40/169 (23%), Positives = 63/169 (37%), Gaps = 8/169 (4%)

Query: 178  RLTYEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDV 237
            R  + E   R      N A           Q S++   E   +    +    R     DV
Sbjct: 1003 REAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDV 1062

Query: 238  --NDQDAIQEKFYP-----PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTV 290
               D    +E+  P     P FI  P    + EG       +V G P P V W  +G  +
Sbjct: 1063 VMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPL 1122

Query: 291  QSDDLHKMIVSEK-GLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQL 338
             +   +K+  +++ G   L+  +  A DAG Y  V +N+ GE + +  L
Sbjct: 1123 TTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 40/158 (25%), Positives = 61/158 (38%), Gaps = 13/158 (8%)

Query: 277  PAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTV 336
            P   V W  + + +Q  D  K I  EK +H L+    R SDAG Y  VA      A   V
Sbjct: 3084 PDITVQWMKDDQELQITDRIK-IQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFV 3142

Query: 337  Q-LDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDR 395
            +  DV  +  K+    I K ++    E +   ++            W ++   + F    
Sbjct: 3143 EGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAH----------WYKDGIEINFQVQE 3192

Query: 396  ISLYQDNTGRVTLLIKDVNKKDAGWYT-VSAVNEAGVT 432
               Y        + I +  + DAG YT V+  N + VT
Sbjct: 3193 RHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVT 3230



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 22/69 (31%), Positives = 34/69 (49%), Gaps = 3/69 (4%)

Query: 257  ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGL-HSLIFEVVRA 315
            +++++ EG    ++ KVS      V WYLN   ++ DD  + IV  KG    L+     A
Sbjct: 2452 KDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIV--KGTKQRLVINRTHA 2509

Query: 316  SDAGAYACV 324
            SD G Y  +
Sbjct: 2510 SDEGPYKLI 2518


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score =  127 bits (320), Expect = 2e-29
 Identities = 66/216 (30%), Positives = 115/216 (53%)

Query: 245  EKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG 304
            E+ Y P F+  P +    EG+  R D KV G P P+  W+ +G+ + +D  HK+++ E G
Sbjct: 1452 ERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDG 1511

Query: 305  LHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGD 364
              SLI      SD+G +  VA+NRAG ++ +V L V A EH+  PMF+ K ++  + EG 
Sbjct: 1512 TQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGS 1571

Query: 365  SVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVS 424
             ++++ + +  P P + W +N++++  +       +   G   L I     +D+ WYT +
Sbjct: 1572 RLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTAT 1631

Query: 425  AVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTF 460
            A+N+AG  T   +++V     +  P  K +  R T+
Sbjct: 1632 AINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTY 1667



 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 62/198 (31%), Positives = 92/198 (46%), Gaps = 7/198 (3%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIV--SEKGLH 306
             PP F     N +   G   R    ++  P P V+WY +G+ ++  D  K     S+KGL+
Sbjct: 31689 PPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLY 31748

Query: 307   SLIFEVVRASDAGAYACVAKNRAGE----ATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE 362
              L    V   D   Y  VA+N+ GE    A  TV L     +    PMF     + +  E
Sbjct: 31749 QLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQE 31808

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G SV  E ++S IPPP L W+++ + +    + I +  +      L I+D   +D G+Y 
Sbjct: 31809 GQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPN-IEIIHEGLDYYALHIRDTLPEDTGYYR 31867

Query: 423   VSAVNEAGVTTCNTRLDV 440
             V+A N AG T+C   L V
Sbjct: 31868 VTATNTAGSTSCQAHLQV 31885



 Score = 93.2 bits (230), Expect = 5e-19
 Identities = 58/203 (28%), Positives = 104/203 (51%), Gaps = 19/203 (9%)

Query: 249  PPRFIQVPENMSI-DEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHS 307
            PP+FI+ P  + +   G+    + +++G P   VSWYL+G  + +   H +   + GL +
Sbjct: 4860 PPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFID-GLAT 4918

Query: 308  LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
                  R  ++G Y C A+N AG A+ +++L V     K  P FI + +  +V++   V+
Sbjct: 4919 FQISGARVENSGTYVCEARNDAGTASCSIELKV-----KEPPTFIRELKPVEVVKYSDVE 4973

Query: 368  LECQISAIPPPKLFWKRNNEMVQFN-----TDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
            LEC+++  PP ++ W +NN  ++ +     TDR+S++        L I   +  D G Y 
Sbjct: 4974 LECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVF-------NLHITKCDPSDTGEYQ 5026

Query: 423  VSAVNEAGVTTCNTRLDVTARPN 445
                NE G  +C+TR+ +   P+
Sbjct: 5027 CIVSNEGGSCSCSTRVALKEPPS 5049



 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 62/213 (29%), Positives = 109/213 (51%), Gaps = 13/213 (6%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVS-EKGLHSL 308
           P F Q  +++ + EG     +  +SG P P+VSW+ +G+ + +  L  + +S   G   L
Sbjct: 6   PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65

Query: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
               V  +++G Y+  A N +G+AT T +L  L K     P F+ + QS  V +G  V+L
Sbjct: 66  TIPAVTKANSGRYSLKATNGSGQATSTAEL--LVKAETAPPNFVQRLQSMTVRQGSQVRL 123

Query: 369 ECQISAIPPPKLFWKRNNEMVQFNTD-RISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
           + +++ IP P + + R+   +Q + D +IS   D     +LLI +   +D+G Y+V+A N
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGD---LYSLLIAEAYPEDSGTYSVNATN 180

Query: 428 EAGVTTCNTRL------DVTARPNQTLPAPKQL 454
             G  T    L      +V A+  +T+ +  Q+
Sbjct: 181 SVGRATSTAELLVQGEEEVPAKKTKTIVSTAQI 213



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 60/231 (25%), Positives = 94/231 (40%), Gaps = 42/231 (18%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP  +   +N+++ EG    ++  +SG P+P V+WY     ++S  +   I  + G+  L
Sbjct: 942  PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESS-IDFQITFQSGIARL 1000

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDV----------------LAKEHKR----- 347
            +     A D+G + C A N AG  + +  L V                   E KR     
Sbjct: 1001 MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESR 1060

Query: 348  --------------------APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNE 387
                                AP FI KP  +K++EG SV   CQ+   P P ++WK++  
Sbjct: 1061 DVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGV 1120

Query: 388  MVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 438
             +         Y   TG   L+I      DAG YT+   N+ G T+ +  L
Sbjct: 1121 PLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 56/203 (27%), Positives = 97/203 (47%), Gaps = 7/203 (3%)

Query: 243  IQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD-LHKMIVS 301
            IQE+  PP F +  +++    G    +  +++G     V WY +G  ++ D+ L    V 
Sbjct: 6168 IQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVD 6227

Query: 302  EKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL 361
                  ++      S +G Y+C A N  G A+ + +L   A+E K++P F  KP S  V+
Sbjct: 6228 NVATLKIL--QTDLSHSGQYSCSASNPLGTASSSARLT--AREPKKSPFFDIKPVSIDVI 6283

Query: 362  EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWY 421
             G+S   EC ++   P ++ W ++N+ ++   +       NT  + +L   V K D+G Y
Sbjct: 6284 AGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRIL--KVGKGDSGQY 6341

Query: 422  TVSAVNEAGVTTCNTRLDVTARP 444
            T  A N+ G   C+ +L V   P
Sbjct: 6342 TCQATNDVGKDMCSAQLSVKEPP 6364



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 62/217 (28%), Positives = 106/217 (48%), Gaps = 11/217 (5%)

Query: 243  IQEKFYPPRFIQ-VPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVS 301
            I+E+  PP F + + E +   EG   +++ +V+G     V+WY N   +Q     ++   
Sbjct: 8242 IKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFK 8301

Query: 302  EKGLHSLIFEVVRA--SDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKK 359
                ++L+ +V +A  +DAG Y C   N AG A  T    ++ KE K+ P+F        
Sbjct: 8302 N---NTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSS--IVIKEPKKPPVFDQHLTPVT 8356

Query: 360  VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
            V EG+ V+L C +    P ++ W +    ++  +DR S +   +G   L ++DV K D+G
Sbjct: 8357 VSEGEYVQLSCHVQGSEPIRIQWLKAGREIK-PSDRCS-FSFASGTAVLELRDVAKADSG 8414

Query: 420  WYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRV 456
             Y   A N AG  T  +++ +  +P    PA K+  V
Sbjct: 8415 DYVCKASNVAGSDTTKSKVTIKDKP-AVAPATKKAAV 8450



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 60/223 (26%), Positives = 104/223 (46%), Gaps = 16/223 (7%)

Query: 243  IQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSE 302
            +QE+  PP F +   ++    G     D  +SG     VSWY +G+ ++     +    +
Sbjct: 8050 VQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLD 8109

Query: 303  KGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE 362
                  IF+  R S AG Y+C A N  G A+ + +L  +  E K  P F  +      + 
Sbjct: 8110 NTATLNIFKTDR-SLAGQYSCTATNPIGSASSSARL--ILTEGKNPPFFDIRLAPVDAVV 8166

Query: 363  GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
            G+S   EC ++   P K+ W +++  ++        Y +N+  +T+L   V+K D+G YT
Sbjct: 8167 GESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVL--KVDKGDSGQYT 8224

Query: 423  VSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLA 465
              AVNE G  +C  +L++           K+  + P+F+K L+
Sbjct: 8225 CYAVNEVGKDSCTAQLNI-----------KERLIPPSFTKRLS 8256



 Score = 82.8 bits (203), Expect = 7e-16
 Identities = 53/197 (26%), Positives = 88/197 (44%), Gaps = 5/197 (2%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P   ++ PE++ +  G  C ++  V+G P     W+ +G+ + SD+ +K+    K +  L
Sbjct: 7585 PATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNK-VSGL 7643

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
                V  SD+G Y+   +N  G+ + T  L V   +    P F  K +    L G SV +
Sbjct: 7644 KIINVAPSDSGVYSFEVQNPVGKDSCTASLQV--SDRTVPPSFTRKLKETNGLSGSSVVM 7701

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            EC++   PP  + W      +       +   DNT    L +  + + D+G YT  A N 
Sbjct: 7702 ECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNT--CALTVNMLEESDSGDYTCIATNM 7759

Query: 429  AGVTTCNTRLDVTARPN 445
            AG   C+  L V   P+
Sbjct: 7760 AGSDECSAPLTVREPPS 7776



 Score = 82.4 bits (202), Expect = 9e-16
 Identities = 80/313 (25%), Positives = 129/313 (41%), Gaps = 43/313 (13%)

Query: 150  IQGSKEALIQDLERKLKCKDTLLHNGNQRLTYEEKMARRLLG---PQNAAA-VFQAQDDS 205
            I+G++   +Q L+ K   ++ +  + N R+T+ E +A        P NA   + Q ++D 
Sbjct: 5633 IEGAQPIFVQWLKEK---EEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDG 5689

Query: 206  GAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGR 265
            G +++       A L V    V               I EK  P         M++  G 
Sbjct: 5690 GMRENM------ATLMVLEPAV---------------IVEKAGP---------MTVTVGE 5719

Query: 266  FCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVA 325
             C ++ KV+G P   V WY +G+ + S   HK     K + SL    V   DAG Y    
Sbjct: 5720 TCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNK-ISSLRILSVERQDAGTYTFQV 5778

Query: 326  KNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRN 385
            +N  G+++ T  +DV   +    P F  + ++   + G S  LEC+++   P  + W   
Sbjct: 5779 QNNVGKSSCTAVVDV--SDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHE 5836

Query: 386  NEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPN 445
               +       + + DN    TL +  ++  D G YT  A N AG   C   L V   P 
Sbjct: 5837 KTKIVSGAKYQTTFSDNV--CTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTV-QEPP 5893

Query: 446  QTLPAPKQLRVRP 458
              +  P+ L V P
Sbjct: 5894 SFVKEPEPLEVLP 5906



 Score = 82.4 bits (202), Expect = 9e-16
 Identities = 61/213 (28%), Positives = 93/213 (43%), Gaps = 6/213 (2%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P R I+ PE M++  G    ++  V+G P     W+ +GR + +D  H +    K + SL
Sbjct: 6644 PARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINK-VASL 6702

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
                   SD G Y+   KN  G++  TV + V   +    P FI K +    + G SV L
Sbjct: 6703 KIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHV--SDRIVPPSFIRKLKDVNAILGASVVL 6760

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            EC++S   P  + W ++   +       S + +N    TL +  +   D G YT  A N 
Sbjct: 6761 ECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENV--CTLNLSLLEPSDTGIYTCVAANV 6818

Query: 429  AGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFS 461
            AG   C+  L V   P+     P  + V P  S
Sbjct: 6819 AGSDECSAVLTVQEPPSFE-QTPDSVEVLPGMS 6850



 Score = 82.4 bits (202), Expect = 9e-16
 Identities = 57/201 (28%), Positives = 94/201 (46%), Gaps = 10/201 (4%)

Query: 243  IQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSE 302
            + ++  PP F +  +  +   G    M+ KV G P   VSW+  G  + S   ++  +++
Sbjct: 7675 VSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTD 7734

Query: 303  KGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE 362
                +L   ++  SD+G Y C+A N AG    +  L V     +  P F+ KP    VL 
Sbjct: 7735 NTC-ALTVNMLEESDSGDYTCIATNMAGSDECSAPLTV-----REPPSFVQKPDPMDVLT 7788

Query: 363  GDSVKLECQISAIPPPKLFW-KRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWY 421
            G +V     +   PP  + W K ++E+V  +   +SL +D+   + L   DV+   +G Y
Sbjct: 7789 GTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSL-EDSVAELELF--DVDTSQSGEY 7845

Query: 422  TVSAVNEAGVTTCNTRLDVTA 442
            T    NEAG  +C T L + A
Sbjct: 7846 TCIVSNEAGKASCTTHLYIKA 7866



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 55/189 (29%), Positives = 91/189 (48%), Gaps = 11/189 (5%)

Query: 249  PPRFIQVPENMSI-DEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKM-IVSEKGLH 306
            PP+F++  E   +  +G   +++ K+SG P   VSW+ N   +     + M  ++   L 
Sbjct: 6363 PPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVAL- 6421

Query: 307  SLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSV 366
             L      A D+G Y C A N  G+A+ +  L V     K  P+F  KP     L+G  V
Sbjct: 6422 -LTINEASAEDSGDYICEAHNGVGDASCSTALTV-----KAPPVFTQKPSPVGALKGSDV 6475

Query: 367  KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAV 426
             L+C+IS  PP ++ W ++ + V+ N+ +  +   +    +L I ++   D G Y   A 
Sbjct: 6476 ILQCEISGTPPFEVVWVKDRKQVR-NSKKFKITSKHFD-TSLHILNLEASDVGEYHCKAT 6533

Query: 427  NEAGVTTCN 435
            NE G  TC+
Sbjct: 6534 NEVGSDTCS 6542



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 62/221 (28%), Positives = 101/221 (45%), Gaps = 20/221 (9%)

Query: 229  SRSTSRGDVNDQDAIQEKFYPPRFIQVPE-NMSIDEGRFCRMDFKVSGLPAPDVSWYLNG 287
            S    +   + Q  +QE   PPRFI+  E +  + +  F R + K+ G P   V WY + 
Sbjct: 7287 SNIAGKDSCSAQLGVQE---PPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDE 7343

Query: 288  RTVQSDDLHKMI----VSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
              +Q     +M     V+   +H+L  E     D+G Y C A N AG A+ +  L V   
Sbjct: 7344 TEIQESSKFRMSFVDSVAVLEMHNLSVE-----DSGDYTCEAHNAAGSASSSTSLKV--- 7395

Query: 344  EHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNT 403
              K  P+F  KP   + L+G  V LEC++   PP  + W ++   ++ +  +  +  +N 
Sbjct: 7396 --KEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELR-SGKKYKIMSENF 7452

Query: 404  GRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARP 444
               ++ I +V+  D G Y   A N+ G  TC   + + A P
Sbjct: 7453 -LTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPP 7492



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 55/182 (30%), Positives = 94/182 (51%), Gaps = 6/182 (3%)

Query: 259   MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDA 318
             MSI+EG+  R+  K +   A DV W LNG  + + + ++  VS     +L  +     D 
Sbjct: 33048 MSINEGQ--RLVLKANIAGATDVKWVLNGVELTNSEEYRYGVSGSD-QTLTIKQASHRDE 33104

Query: 319   GAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPP 378
             G   C++K + G       L  L+KE   AP FI +P+S+ + EG +V   C+IS  P P
Sbjct: 33105 GILTCISKTKEGIVKCQYDL-TLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSP 33163

Query: 379   KLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 438
             ++ W +NN  +  +++ +S+ + +    +L I++ +  D+G YT+ A N  G  +    L
Sbjct: 33164 EIEWFKNNLPISISSN-VSISR-SRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASL 33221

Query: 439   DV 440
              V
Sbjct: 33222 MV 33223



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 53/197 (26%), Positives = 83/197 (42%), Gaps = 2/197 (1%)

Query: 250   PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG-LHSL 308
             P F +   N+++       +  KV+G P P V WY  G+ + +D L   I   KG  H L
Sbjct: 30928 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQL 30987

Query: 309   IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
             I   V   DA  Y   A N+ G  + T  L+V        P  +    +   L G+ V +
Sbjct: 30988 IIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSI 31047

Query: 369   ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
             +   S  P P + W++  +++  N     +    +    +    V +KDAG+Y V A N 
Sbjct: 31048 KIPFSGKPDPVITWQKGQDLID-NNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNR 31106

Query: 429   AGVTTCNTRLDVTARPN 445
              G+      LDV   P+
Sbjct: 31107 FGIDQKTVELDVADVPD 31123



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 61/233 (26%), Positives = 104/233 (44%), Gaps = 6/233 (2%)

Query: 243  IQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSE 302
            I+ +  PP F +  +++    G     + +++G     VSWY +G  +  DD +      
Sbjct: 7109 IKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDG-VLLKDDANLQTSFV 7167

Query: 303  KGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE 362
              + +L       S  G Y C A N  G A+ + +L  +  EH+  P F  KP S  +  
Sbjct: 7168 HNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKL--ILSEHEVPPFFDLKPVSVDLAL 7225

Query: 363  GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
            G+S   +C ++   P K+ W ++N  ++   +      +NT  +T+L   V K DAG YT
Sbjct: 7226 GESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVL--KVGKGDAGQYT 7283

Query: 423  VSAVNEAGVTTCNTRLDVTARPNQTLP-APKQLRVRPTFSKYLALNGKGLNVK 474
              A N AG  +C+ +L V   P       P ++  +  F++Y    G    +K
Sbjct: 7284 CYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIK 7336



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 59/218 (27%), Positives = 103/218 (47%), Gaps = 23/218 (10%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P +F++   + SI++G+   ++   +G P   V+W  NG  V       +  +EK   S 
Sbjct: 7867 PAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEK---SA 7923

Query: 309  IFEVVRAS--DAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSV 366
            I E+  ++  DAG Y C  +N +G+ + + Q+ +L       P F+ + +  KV  GDS 
Sbjct: 7924 ILEIPSSTVEDAGQYNCYIENASGKDSCSAQILIL-----EPPYFVKQLEPVKVSVGDSA 7978

Query: 367  KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAV 426
             L+CQ++  P   + W + +  ++  T     +++N    TL+   V+  D+G Y   A 
Sbjct: 7979 SLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNV--ATLVFNQVDINDSGEYICKAE 8036

Query: 427  NEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYL 464
            N  G  + +T L V     Q LP        P+FS+ L
Sbjct: 8037 NSVGEVSASTFLTV---QEQKLP--------PSFSRQL 8063



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 54/196 (27%), Positives = 86/196 (43%), Gaps = 9/196 (4%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PPRF++   ++S   G+  ++   + G     V W+ +   +  +  +  I   + + +L
Sbjct: 7491 PPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATL 7550

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
             F  V  ++AG Y C  KN AG       L VL          + KP+S KV  GD+  L
Sbjct: 7551 QFSRVEPANAGKYTCQIKNDAGMQECFATLSVL-----EPATIVEKPESIKVTTGDTCTL 7605

Query: 369  ECQISAIPPPKLFW-KRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
            EC ++  P     W K   E+   N  +IS +   +G   L I +V   D+G Y+    N
Sbjct: 7606 ECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSG---LKIINVAPSDSGVYSFEVQN 7662

Query: 428  EAGVTTCNTRLDVTAR 443
              G  +C   L V+ R
Sbjct: 7663 PVGKDSCTASLQVSDR 7678



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 59/209 (28%), Positives = 93/209 (44%), Gaps = 10/209 (4%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP F + P  +   +G    ++ ++ G P   VSWY + R ++S   +K I+SE  L S+
Sbjct: 7398 PPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYK-IMSENFLTSI 7456

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
                V A+D G Y C A N  G  T    + +     K  P F+ K      + G  V+L
Sbjct: 7457 HILNVDAADIGEYQCKATNDVGSDTCVGSIAL-----KAPPRFVKKLSDISTVVGKEVQL 7511

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISL-YQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
            +  I    P  + W ++   +   +D I + Y +N    TL    V   +AG YT    N
Sbjct: 7512 QTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENI--ATLQFSRVEPANAGKYTCQIKN 7569

Query: 428  EAGVTTCNTRLDVTARPNQTLPAPKQLRV 456
            +AG+  C   L V   P   +  P+ ++V
Sbjct: 7570 DAGMQECFATLSV-LEPATIVEKPESIKV 7597



 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 65/222 (29%), Positives = 103/222 (46%), Gaps = 18/222 (8%)

Query: 221  QVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPD 280
            QV  +  +S  T+  DV+D+        PP F +  +N     G  C ++ KV+G     
Sbjct: 5777 QVQNNVGKSSCTAVVDVSDRAV------PPSFTRRLKNTGGVLGASCILECKVAGSSPIS 5830

Query: 281  VSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
            V+W+     + S   ++   S+  + +L    + +SD G Y CVA N AG       L V
Sbjct: 5831 VAWFHEKTKIVSGAKYQTTFSD-NVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTV 5889

Query: 341  LAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRN-NEMVQFNTDRISLY 399
                 +  P F+ +P+  +VL G +V     I   PP K+ W R   E+V+   DR ++Y
Sbjct: 5890 -----QEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVK--GDRCNIY 5942

Query: 400  -QDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
             +D    + L   D+++  +G YT    N AG  +C TRL V
Sbjct: 5943 FEDTVAELELFNIDISQ--SGEYTCVVSNNAGQASCTTRLFV 5982



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 53/198 (26%), Positives = 99/198 (50%), Gaps = 11/198 (5%)

Query: 250  PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
            P FI+  E +     +   ++ +V       V+W  +G+ +     +K+   +K + +L 
Sbjct: 3644 PHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDK-IATLE 3702

Query: 310  FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQ-SKKVLEGDSVKL 368
              + +  D+G Y C A N AG ++ +  + V     +  P F+ K   S  +L G+S +L
Sbjct: 3703 IPLAKLKDSGTYVCTASNEAGSSSCSATVTV-----REPPSFVKKVDPSYLMLPGESARL 3757

Query: 369  ECQISAIPPPKLFWKRNN-EMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
             C++   P  ++ W +NN E+ + NT R  +Y  N+  + L I DV  +D+G Y+  AVN
Sbjct: 3758 HCKLKGSPVIQVTWFKNNKELSESNTVR--MYFVNSEAI-LDITDVKVEDSGSYSCEAVN 3814

Query: 428  EAGVTTCNTRLDVTARPN 445
            + G  +C+T + +   P+
Sbjct: 3815 DVGSDSCSTEIVIKEPPS 3832



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 65/245 (26%), Positives = 110/245 (44%), Gaps = 22/245 (8%)

Query: 209  DSQQHNS---EHARLQVPTSQVRSR---------STSRGDVNDQDAIQEKFYPPRFIQVP 256
            DS+ H +   + A L++P +++  +         S  + +      + ++  PP FI+  
Sbjct: 6688 DSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKL 6747

Query: 257  ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRAS 316
            ++++   G    ++ +VSG     V W+ +G  + S    +   SE  + +L   ++  S
Sbjct: 6748 KDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSE-NVCTLNLSLLEPS 6806

Query: 317  DAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIP 376
            D G Y CVA N AG    +  L V     +  P F   P S +VL G S+     I   P
Sbjct: 6807 DTGIYTCVAANVAGSDECSAVLTV-----QEPPSFEQTPDSVEVLPGMSLTFTSVIRGTP 6861

Query: 377  PPKLFW-KRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCN 435
            P K+ W K + E+V   +  ISL    T    L + +V   ++G Y+    N+AG  +C 
Sbjct: 6862 PFKVKWFKGSRELVPGESCNISLEDFVT---ELELFEVQPLESGDYSCLVTNDAGSASCT 6918

Query: 436  TRLDV 440
            T L V
Sbjct: 6919 THLFV 6923



 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 57/228 (25%), Positives = 95/228 (41%), Gaps = 8/228 (3%)

Query: 248  YPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHS 307
            YPP F+  P++++   G+  +    V+G P  +  W  +G  + S   +  I   +  H 
Sbjct: 3549 YPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAAL-SPSPNWRISDAENKHI 3607

Query: 308  LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
            L    +   D G Y+C A N+ G      +L ++ K H     FI + +  +      V 
Sbjct: 3608 LELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPH-----FIKELEPVQSAINKKVH 3662

Query: 368  LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
            LECQ+       + W ++ + +    D    ++D     TL I     KD+G Y  +A N
Sbjct: 3663 LECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIA--TLEIPLAKLKDSGTYVCTASN 3720

Query: 428  EAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQ 475
            EAG ++C+  + V   P+          + P  S  L    KG  V Q
Sbjct: 3721 EAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQ 3768



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 52/196 (26%), Positives = 92/196 (46%), Gaps = 9/196 (4%)

Query: 250  PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
            P F   P ++ +  G     +  V+G     ++W  + + ++    + +       H  I
Sbjct: 6271 PFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRI 6330

Query: 310  FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL-EGDSVKL 368
             +V +  D+G Y C A N  G+   + QL V     K  P F+ K ++ KV  +G+S++L
Sbjct: 6331 LKVGKG-DSGQYTCQATNDVGKDMCSAQLSV-----KEPPKFVKKLEASKVAKQGESIQL 6384

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            EC+IS  P  K+ W RN+  +  +      + ++   +T  I + + +D+G Y   A N 
Sbjct: 6385 ECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLT--INEASAEDSGDYICEAHNG 6442

Query: 429  AGVTTCNTRLDVTARP 444
             G  +C+T L V A P
Sbjct: 6443 VGDASCSTALTVKAPP 6458



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 48/187 (25%), Positives = 87/187 (46%), Gaps = 9/187 (4%)

Query: 249  PPRFIQVPENMSIDE-GRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHS 307
            PP+F++  E   I + G   R++ K++G P   V W+ N   + + D ++M   +  +  
Sbjct: 5422 PPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDS-VAV 5480

Query: 308  LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
            +    +   D+G + C A+N AG  + + ++ V     K  P+F   P   + L+   V 
Sbjct: 5481 IQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIV-----KEPPVFSSFPPIVETLKNAEVS 5535

Query: 368  LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
            LEC++S  PP ++ W ++    Q  + +           ++ I +V+  D G Y   A N
Sbjct: 5536 LECELSGTPPFEVVWYKDKR--QLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQN 5593

Query: 428  EAGVTTC 434
            E G  TC
Sbjct: 5594 EVGSDTC 5600



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 52/198 (26%), Positives = 87/198 (43%), Gaps = 5/198 (2%)

Query: 241  DAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIV 300
            +A+     PP FI+  E++    G    +  KV G P   +SWY     ++S   +KM  
Sbjct: 7011 EALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKM-Q 7069

Query: 301  SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKV 360
             +  + SL+   V  SD G Y+C A N  G    +  L  + K  K  P F  K +    
Sbjct: 7070 FKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVL--VIKARKLPPFFARKLKDVHE 7127

Query: 361  LEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGW 420
              G  V  EC+I+   P ++ W ++  +++ + +  + +  N    TL I   ++   G 
Sbjct: 7128 TLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNV--ATLQILQTDQSHIGQ 7185

Query: 421  YTVSAVNEAGVTTCNTRL 438
            Y  SA N  G  + + +L
Sbjct: 7186 YNCSASNPLGTASSSAKL 7203



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 57/192 (29%), Positives = 85/192 (44%), Gaps = 10/192 (5%)

Query: 250  PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
            P F +   N+       CR+D K++G     VSW+ +G+ + + D +++   E G  SL 
Sbjct: 4113 PFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVE-GTASLE 4171

Query: 310  FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLE 369
               V  +DAG + C A N  G    +  L V     +  P F+ KP SK VL G +V L+
Sbjct: 4172 IIRVDMNDAGNFTCRATNSVGSKDSSGALIV-----QEPPSFVTKPGSKDVLPGSAVCLK 4226

Query: 370  CQISAIPPPKLFW-KRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
                   P  + W K N E+V   +  I+     +     L+K     D+G YT    N 
Sbjct: 4227 STFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVK---TSDSGTYTCKVSNV 4283

Query: 429  AGVTTCNTRLDV 440
            AG   C+  L V
Sbjct: 4284 AGGVECSANLFV 4295



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 56/227 (24%), Positives = 100/227 (44%), Gaps = 13/227 (5%)

Query: 230  RSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRT 289
            RS+ +  +N  D I     PP F +  + M   +G F  ++  V+G     + W+ + + 
Sbjct: 4659 RSSCKARINVLDLI----IPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQE 4714

Query: 290  VQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAP 349
            + + + +K    +      I ++   +D+G Y C A N+AG    +  L V     K  P
Sbjct: 4715 ISASEKYKFSFHDNTAFLEISQL-EGTDSGTYTCSATNKAGHNQCSGHLTV-----KEPP 4768

Query: 350  MFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLL 409
             F+ KPQS+ V     V+L+  +    P  + W ++N+ +     R S+++D+T   +L 
Sbjct: 4769 YFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAAR-SVWKDDTS-TSLE 4826

Query: 410  IKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRV 456
            +      D+G Y     N+ G  T    L V   P Q +  P  + V
Sbjct: 4827 LFAAKATDSGTYICQLSNDVGTATSKATLFV-KEPPQFIKKPSPVLV 4872



 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 50/198 (25%), Positives = 91/198 (45%), Gaps = 11/198 (5%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHS- 307
            PP F+  P +  +  G    +     G     + W+   + + S       ++++ L S 
Sbjct: 4205 PPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGG--SCYITKEALESS 4262

Query: 308  LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE-GDSV 366
            L   +V+ SD+G Y C   N AG    +  L V     K    F+ K +  ++L+ GD+ 
Sbjct: 4263 LELYLVKTSDSGTYTCKVSNVAGGVECSANLFV-----KEPATFVEKLEPSQLLKKGDAT 4317

Query: 367  KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAV 426
            +L C+++  PP K+ W  N+  ++ ++     + ++T    L + DV  +D+G Y   A 
Sbjct: 4318 QLACKVTGTPPIKITWFANDREIKESSKHRMSFVEST--AVLRLTDVGIEDSGEYMCEAQ 4375

Query: 427  NEAGVTTCNTRLDVTARP 444
            NEAG   C++ + V   P
Sbjct: 4376 NEAGSDHCSSIVIVKESP 4393



 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 48/208 (23%), Positives = 95/208 (45%), Gaps = 9/208 (4%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP FI+  + + + +     ++ +V+G P  +V+W  N R ++S   + +      + +L
Sbjct: 4954 PPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTL-TDRVSVFNL 5012

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
                   SD G Y C+  N  G  + + ++ +     K  P FI K ++   +   S   
Sbjct: 5013 HITKCDPSDTGEYQCIVSNEGGSCSCSTRVAL-----KEPPSFIKKIENTTTVLKSSATF 5067

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            +  ++  PP  + W ++++++  + +    + D+    TL I+ V+   +G YT  A NE
Sbjct: 5068 QSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVA--TLQIRSVDNGHSGRYTCQAKNE 5125

Query: 429  AGVTTCNTRLDVTARPNQTLPAPKQLRV 456
            +GV  C   L +   P Q +   K + V
Sbjct: 5126 SGVERCYAFL-LVQEPAQIVEKAKSVDV 5152



 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 46/197 (23%), Positives = 91/197 (46%), Gaps = 12/197 (6%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P  F++   + S++ G+   ++   +G     V+W  +G  + + +   ++ +EK   + 
Sbjct: 5985 PAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEK---TC 6041

Query: 309  IFEVVRAS--DAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSV 366
            I E++ ++  DAG Y+C  +N AG       +  L       P F+ + +  +   GDSV
Sbjct: 6042 ILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTL-----EPPYFVTELEPLEAAVGDSV 6096

Query: 367  KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAV 426
             L+CQ++  P   + W + +  ++   +  + + +N    TL+   VN  D+G YT  A 
Sbjct: 6097 SLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNV--ATLVFNKVNINDSGEYTCKAE 6154

Query: 427  NEAGVTTCNTRLDVTAR 443
            N  G  +  T   +  R
Sbjct: 6155 NSIGTASSKTVFRIQER 6171



 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 92/345 (26%), Positives = 134/345 (38%), Gaps = 47/345 (13%)

Query: 127  QPINAKPSQTAN-AKPIPRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQRLTYEEKM 185
            QP+  +  + A     I   P  +I   KE   Q L    KCK   LH+G +   Y   +
Sbjct: 3246 QPVTVQSGKPARFCAVISGRPQPKISWYKEE--QLLSTGFKCK--FLHDGQE---YTLLL 3298

Query: 186  ARRLLGPQNAAA-VFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQ 244
                  P++AA    +A++D G   +       A L V   +V S         DQ+   
Sbjct: 3299 IEAF--PEDAAVYTCEAKNDYGVATTS------ASLSVEVPEVVSP--------DQEM-- 3340

Query: 245  EKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG 304
               YPP  I   ++    EG+  R   +VSG     VSWY   + ++     +M   E  
Sbjct: 3341 -PVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLK-VSWYSKDKKIKPSRFFRMTQFEDT 3398

Query: 305  LHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEH--------------KRAPM 350
                I E     D G Y  VA N  G+ + T  L + A E               K AP+
Sbjct: 3399 YQLEIAEAY-PEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPV 3457

Query: 351  FIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLI 410
               K +  +V  G   K  C+I + P  +  W +    + + +D+ S+ + +    +L I
Sbjct: 3458 IKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREI-YESDKCSI-RSSKYISSLEI 3515

Query: 411  KDVNKKDAGWYTVSAVNEAGVTTCNTRLDVT-ARPNQTLPAPKQL 454
                  D G YT  A NE G  +C   L VT A P   L  PK L
Sbjct: 3516 LRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSL 3560



 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 56/214 (26%), Positives = 89/214 (41%), Gaps = 12/214 (5%)

Query: 243  IQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSE 302
            I+E   PP F Q    +++ EG + ++   V G     + W   GR ++  D      + 
Sbjct: 8339 IKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFAS 8398

Query: 303  KGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDV-----LAKEHKRAPM-----FI 352
             G   L    V  +D+G Y C A N AG  T   ++ +     +A   K+A +     F+
Sbjct: 8399 -GTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFV 8457

Query: 353  YKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKD 412
             +PQS +V+E  +     ++   P P + W +          R+ ++Q       L I+D
Sbjct: 8458 SEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGD-EAKLEIRD 8516

Query: 413  VNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQ 446
              K D+G Y   A NE G    N  L V  R  Q
Sbjct: 8517 TTKTDSGLYRCVAFNEHGEIESNVNLQVDERKKQ 8550



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 51/185 (27%), Positives = 81/185 (43%), Gaps = 8/185 (4%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP FI+  E   I  G    +  +VSG    ++SW+ + + ++S   +++  S+K L  L
Sbjct: 3830 PPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLF-SQKSLVCL 3888

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
                  ++D G Y CV  N  G+        +     K  P F+ K      L G +V L
Sbjct: 3889 EIFSFNSADVGEYECVVANEVGKCGC-----MATHLLKEPPTFVKKVDDLIALGGQTVTL 3943

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            +  +    P  + W +  E+++    +I +   N G   L+I DV     G YT  A NE
Sbjct: 3944 QAAVRGSEPISVTWMKGQEVIR-EDGKIKMSFSN-GVAVLIIPDVQISFGGKYTCLAENE 4001

Query: 429  AGVTT 433
            AG  T
Sbjct: 4002 AGSQT 4006



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 51/198 (25%), Positives = 82/198 (41%), Gaps = 12/198 (6%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP F++ PE + +  G+       + G P   V+W+   R +   D   +   +      
Sbjct: 5892 PPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELE 5951

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
            +F  +  S +G Y CV  N AG+A+ T +L V     K    F+ +     V  G S+ L
Sbjct: 5952 LFN-IDISQSGEYTCVVSNNAGQASCTTRLFV-----KEPAAFLKRLSDHSVEPGKSIIL 6005

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVN--KKDAGWYTVSAV 426
            E   +   P  + WK++     FN          T   T +++ +N  K+DAG Y+    
Sbjct: 6006 ESTYTGTLPISVTWKKDG----FNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIE 6061

Query: 427  NEAGVTTCNTRLDVTARP 444
            NEAG   C   +     P
Sbjct: 6062 NEAGRDVCGALVSTLEPP 6079



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 59/225 (26%), Positives = 97/225 (43%), Gaps = 15/225 (6%)

Query: 235  GDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD 294
            GD +   A+  K  PP F Q P  +   +G    +  ++SG P  +V W  + + V++  
Sbjct: 6444 GDASCSTALTVKA-PPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSK 6502

Query: 295  LHKMIVS--EKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFI 352
              K+     +  LH L  E   ASD G Y C A N  G  T +  +     + K  P F+
Sbjct: 6503 KFKITSKHFDTSLHILNLE---ASDVGEYHCKATNEVGSDTCSCSV-----KFKEPPRFV 6554

Query: 353  YKPQSKKVLEGDSVKLECQISAIPPPKLFW-KRNNEMVQFNTDRISLYQDNTGRVTLLIK 411
             K      L GD+V+L   +    P  + W K   E+++ + +    + DN    TL + 
Sbjct: 6555 KKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNI--ATLQLG 6612

Query: 412  DVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRV 456
                 ++G Y     N+AG+  C+  L V   P + +  P+ + V
Sbjct: 6613 SPEASNSGKYICQIKNDAGMRECSAVLTV-LEPARIIEKPEPMTV 6656



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 50/198 (25%), Positives = 93/198 (46%), Gaps = 9/198 (4%)

Query: 249  PPRFIQVPE-NMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHS 307
            P  F++  E +  + +G   ++  KV+G P   ++W+ N R ++    H+M   E     
Sbjct: 4298 PATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVL 4357

Query: 308  LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
             + +V    D+G Y C A+N AG    +  + V     K +P F  + +  +VL+   V 
Sbjct: 4358 RLTDV-GIEDSGEYMCEAQNEAGSDHCSSIVIV-----KESPYFTKEFKPIEVLKEYDVM 4411

Query: 368  LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
            L  +++  PP ++ W ++N +++      +  QD+   V+L I      DAG Y     N
Sbjct: 4412 LLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHL--VSLQILKFVAADAGEYQCRVTN 4469

Query: 428  EAGVTTCNTRLDVTARPN 445
            E G + C+ R+ +   P+
Sbjct: 4470 EVGSSICSARVTLREPPS 4487



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 50/208 (24%), Positives = 96/208 (46%), Gaps = 7/208 (3%)

Query: 242  AIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVS 301
            A+     PP F+   E +    G    +  +V+G P   VSWY     ++    ++   +
Sbjct: 6071 ALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFT 6130

Query: 302  EKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL 361
               + +L+F  V  +D+G Y C A+N  G A+      +  +E +  P F  + +  +  
Sbjct: 6131 -NNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRI--QERQLPPSFARQLKDIEQT 6187

Query: 362  EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWY 421
             G  V L C+++   P ++ W R+  +++ + +  + + DN   + +L  D++   +G Y
Sbjct: 6188 VGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLS--HSGQY 6245

Query: 422  TVSAVNEAGVTTCNTRLDVTARPNQTLP 449
            + SA N  G  + + RL  TAR  +  P
Sbjct: 6246 SCSASNPLGTASSSARL--TAREPKKSP 6271



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 53/197 (26%), Positives = 86/197 (43%), Gaps = 10/197 (5%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP F +    M    G    M+ KVSG       W+ +G+ + +   ++++  E+ + SL
Sbjct: 5236 PPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSV-SL 5294

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
                +   D   Y C   N AG+   +  L V     K  P F+ KP  ++ +   +V+ 
Sbjct: 5295 EVNNLELEDTANYTCKVSNVAGDDACSGILTV-----KEPPSFLVKPGRQQAIPDSTVEF 5349

Query: 369  ECQISAIPPPKLFW-KRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
            +  +   PP K+ W K + E+V      I L + +T  + L   D +K   G YT    N
Sbjct: 5350 KAILKGTPPFKIKWFKDDVELVSGPKCFIGL-EGSTSFLNLYSVDASK--TGQYTCHVTN 5406

Query: 428  EAGVTTCNTRLDVTARP 444
            + G  +C T L VT  P
Sbjct: 5407 DVGSDSCTTMLLVTEPP 5423



 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 55/234 (23%), Positives = 105/234 (44%), Gaps = 29/234 (12%)

Query: 249  PPRFIQ-VPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTV-QSDDLHKMIVSEKGLH 306
            PP F++ V  +  +  G   R+  K+ G P   V+W+ N + + +S+ +    V+ + + 
Sbjct: 3736 PPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAI- 3794

Query: 307  SLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSV 366
             L    V+  D+G+Y+C A N  G  + + ++ +     K  P FI   +   ++ G + 
Sbjct: 3795 -LDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVI-----KEPPSFIKTLEPADIVRGTNA 3848

Query: 367  KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAV 426
             L+C++S   P ++ W ++ + ++ ++ +  L+   +  V L I   N  D G Y     
Sbjct: 3849 LLQCEVSGTGPFEISWFKDKKQIR-SSKKYRLFSQKS-LVCLEIFSFNSADVGEYECVVA 3906

Query: 427  NEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSK----YLALNGKGLNVKQA 476
            NE G   C               A   L+  PTF K     +AL G+ + ++ A
Sbjct: 3907 NEVGKCGC--------------MATHLLKEPPTFVKKVDDLIALGGQTVTLQAA 3946



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 54/196 (27%), Positives = 86/196 (43%), Gaps = 10/196 (5%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP F++  +++    G+   +   V G     V+W      ++ D   KM  S  G+  L
Sbjct: 3923 PPTFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSN-GVAVL 3981

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
            I   V+ S  G Y C+A+N AG  T   +L V     K     I + +  +V  GD   L
Sbjct: 3982 IIPDVQISFGGKYTCLAENEAGSQTSVGELIV-----KEPAKIIERAELIQVTAGDPATL 4036

Query: 369  ECQISAIPPPKLFW-KRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
            E  ++  P  K  W K    +V     RIS +++N  ++     +++  D+G YT    N
Sbjct: 4037 EYTVAGTPELKPKWYKDGRPLVASKKYRIS-FKNNVAQLKFYSAELH--DSGQYTFEISN 4093

Query: 428  EAGVTTCNTRLDVTAR 443
            E G ++C T   V  R
Sbjct: 4094 EVGSSSCETTFTVLDR 4109



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 48/196 (24%), Positives = 82/196 (41%), Gaps = 8/196 (4%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP F+Q P+ M +  G        V G P   VSW+     +   D   + + +      
Sbjct: 7774 PPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELE 7833

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
            +F+ V  S +G Y C+  N AG+A+ T  L +     K    F+ +     + +G  + L
Sbjct: 7834 LFD-VDTSQSGEYTCIVSNEAGKASCTTHLYI-----KAPAKFVKRLNDYSIEKGKPLIL 7887

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            E   +  PP  + WK+N   V   + R ++       + L I     +DAG Y     N 
Sbjct: 7888 EGTFTGTPPISVTWKKNGINVT-PSQRCNITTTEKSAI-LEIPSSTVEDAGQYNCYIENA 7945

Query: 429  AGVTTCNTRLDVTARP 444
            +G  +C+ ++ +   P
Sbjct: 7946 SGKDSCSAQILILEPP 7961



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 39/126 (30%), Positives = 64/126 (50%), Gaps = 1/126 (0%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
           PP F+Q  ++M++ +G   R+  +V+G+P P V +Y +G  +QS  L   I  E  L+SL
Sbjct: 103 PPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQS-SLDFQISQEGDLYSL 161

Query: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
           +       D+G Y+  A N  G AT T +L V  +E   A        + ++ E    ++
Sbjct: 162 LIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRI 221

Query: 369 ECQISA 374
           E +I A
Sbjct: 222 EKKIEA 227



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 56/223 (25%), Positives = 96/223 (43%), Gaps = 19/223 (8%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP FI+  EN +            V+G P   ++W  + + +  DD +  I     + +L
Sbjct: 5047 PPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDD-NVYISFVDSVATL 5105

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
                V    +G Y C AKN +G       L V     +     + K +S  V E D + L
Sbjct: 5106 QIRSVDNGHSGRYTCQAKNESGVERCYAFLLV-----QEPAQIVEKAKSVDVTEKDPMTL 5160

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            EC ++  P  K+ W ++ + +  +      +++N    +  I+ V K+D+G YT    N+
Sbjct: 5161 ECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNV--ASFRIQSVMKQDSGQYTFKVEND 5218

Query: 429  AGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGL 471
             G ++C+  L V    +Q +P        P+F+K L    K L
Sbjct: 5219 FGSSSCDAYLRVL---DQNIP--------PSFTKKLTKMDKVL 5250



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 46/196 (23%), Positives = 82/196 (41%), Gaps = 9/196 (4%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PPRF+    ++++  G    +   + G     V W      V  +  +  I   + + +L
Sbjct: 5609 PPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATL 5668

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
             F     ++AG Y C  KN  G       L VL        + + K     V  G++  L
Sbjct: 5669 QFAKAEPANAGKYICQIKNDGGMRENMATLMVL-----EPAVIVEKAGPMTVTVGETCTL 5723

Query: 369  ECQISAIPPPKLFWKRNNEMV-QFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
            EC+++  P   + W ++ +++      + S Y   +   +L I  V ++DAG YT    N
Sbjct: 5724 ECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKIS---SLRILSVERQDAGTYTFQVQN 5780

Query: 428  EAGVTTCNTRLDVTAR 443
              G ++C   +DV+ R
Sbjct: 5781 NVGKSSCTAVVDVSDR 5796



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 52/214 (24%), Positives = 90/214 (42%), Gaps = 20/214 (9%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP+ +Q  + +++  G+  R    +SG P P +SWY   + + +    K +   +    L
Sbjct: 3238 PPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLL 3297

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKE--HKRAPMFIYKP------QSKKV 360
            + E     DA  Y C AKN  G AT +  L V   E       M +Y P      Q    
Sbjct: 3298 LIEAF-PEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVT 3356

Query: 361  LEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGW 420
             EG   + +C++S       ++ ++ ++      R++ ++D      L I +   +D G 
Sbjct: 3357 SEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDT---YQLEIAEAYPEDEGT 3413

Query: 421  YTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQL 454
            YT  A N  G         V++  N +L AP+ +
Sbjct: 3414 YTFVASNAVG--------QVSSTANLSLEAPESI 3439



 Score = 62.4 bits (150), Expect = 9e-10
 Identities = 49/198 (24%), Positives = 86/198 (43%), Gaps = 11/198 (5%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP F+  P                + G P   + W+ +   + S    K  +  +G  S 
Sbjct: 5329 PPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGP--KCFIGLEGSTSF 5386

Query: 309  I-FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE-GDSV 366
            +    V AS  G Y C   N  G  + T  L V        P F+ K ++ K+++ GDS 
Sbjct: 5387 LNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVT-----EPPKFVKKLEASKIVKAGDSS 5441

Query: 367  KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAV 426
            +LEC+I+  P  ++ W RN   +  +      + D+   + +   +++ +D+G +   A 
Sbjct: 5442 RLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQM--NNLSTEDSGDFICEAQ 5499

Query: 427  NEAGVTTCNTRLDVTARP 444
            N AG T+C+T++ V   P
Sbjct: 5500 NPAGSTSCSTKVIVKEPP 5517



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 52/176 (29%), Positives = 78/176 (44%), Gaps = 16/176 (9%)

Query: 280  DVSWYLNGRTV--QSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQ 337
            D  WY +G  +  Q  + HK +V E+ +H +     R SDAG Y  V    AG    +V 
Sbjct: 3176 DAHWYKDGIEINFQVQERHKYVV-ERRIHRMFISETRQSDAGEYTFV----AGRNRSSVT 3230

Query: 338  LDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRIS 397
            L V A E    P  + + Q   V  G   +    IS  P PK+ W +  +++  +T    
Sbjct: 3231 LYVNAPE---PPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLL--STGFKC 3285

Query: 398  LYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV----TARPNQTLP 449
             +  +    TLL+ +   +DA  YT  A N+ GV T +  L V       P+Q +P
Sbjct: 3286 KFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMP 3341



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 48/185 (25%), Positives = 81/185 (43%), Gaps = 11/185 (5%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP F   P  +   +     ++ ++SG P  +V WY + R ++S   +K  ++ K  H+ 
Sbjct: 5516 PPVFSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKDKRQLRSSKKYK--IASKNFHTS 5573

Query: 309  IFEV-VRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
            I  + V  SD G Y C A+N  G  T    + +     K  P F+ K  S  V+ G+  +
Sbjct: 5574 IHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKL-----KEPPRFVSKLNSLTVVAGEPAE 5628

Query: 368  LECQISAIPPPKLFWKRNNEMVQFNTDRISL-YQDNTGRVTLLIKDVNKKDAGWYTVSAV 426
            L+  I    P  + W +  E V   ++ I + + +N    TL        +AG Y     
Sbjct: 5629 LQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENV--ATLQFAKAEPANAGKYICQIK 5686

Query: 427  NEAGV 431
            N+ G+
Sbjct: 5687 NDGGM 5691



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 50/209 (23%), Positives = 84/209 (40%), Gaps = 30/209 (14%)

Query: 281   VSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
             V+WY   R +++ + ++ I  E G+  L  + +   D G Y C   N  GE +   +L V
Sbjct: 31600 VTWYFGVRQLENSEKYE-ITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFV 31658

Query: 341   LAKEH-----------------------KRAPMFIYKPQSKKVLEGDSVKLECQISAIPP 377
                                         +R P F     +K    G++V+    I+  P 
Sbjct: 31659 KGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPE 31718

Query: 378   PKLFWKRNNEMVQ-FNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
             P + W ++ + ++  + D+   ++ + G   L I  V   D   YTV A N+ G  +C  
Sbjct: 31719 PHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKA 31778

Query: 437   RLDVTARPNQTLPAPKQLRVRPTFSKYLA 465
             +L VT       P P    +RP F + LA
Sbjct: 31779 KLTVTLH-----PPPTDSTLRPMFKRLLA 31802



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 47/185 (25%), Positives = 87/185 (47%), Gaps = 8/185 (4%)

Query: 264   GRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYAC 323
             G   ++  ++ G P PD+ WY  G+ +     +KM  S+   H+L        D G Y C
Sbjct: 30547 GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKM-SSDGRTHTLTVMTEEQEDEGVYTC 30605

Query: 324   VAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWK 383
             +A N  GE   + +L +L    +  P +  K +    + G +++L       P P + W 
Sbjct: 30606 IATNEVGEVETSSKL-LLQATPQFHPGYPLKEKYYGAV-GSTLRLHVMYIGRPVPAMTWF 30663

Query: 384   RNNEMVQFNTDRISLYQDNTGRVT-LLIKDVNKK-DAGWYTVSAVNEAGVTTCNTRLDVT 441
                +++Q N++ I++  +NT   T L++K+V +K  AG Y V   N  G       +++ 
Sbjct: 30664 HGQKLLQ-NSENITI--ENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQ 30720

Query: 442   ARPNQ 446
              +P++
Sbjct: 30721 DKPDK 30725



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 36/117 (30%), Positives = 59/117 (50%), Gaps = 2/117 (1%)

Query: 324  VAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWK 383
            V   R  + T T ++    +     P  +   ++  V+EG+SV LEC IS  P P + W 
Sbjct: 918  VLHGREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWY 977

Query: 384  RNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
            R +  ++ + D    +Q    R  L+I++   +D+G +T SAVNEAG  + +  L V
Sbjct: 978  REDYQIESSIDFQITFQSGIAR--LMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV 1032



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 37/169 (21%), Positives = 79/169 (46%), Gaps = 8/169 (4%)

Query: 272  KVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGE 331
            +V+G P  +++W+ +   ++S   +K  + +  +   I + V A+DAG Y C   N  G 
Sbjct: 4415 EVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFV-AADAGEYQCRVTNEVGS 4473

Query: 332  ATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQF 391
            +  + ++ +     +  P FI K +S   L G +   +  +    P  + W ++++ +  
Sbjct: 4474 SICSARVTL-----REPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITE 4528

Query: 392  NTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
            + +    +++N    +L +  +  K  G Y   A N+AG+  C+  L V
Sbjct: 4529 DDNIRMTFENNV--ASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSV 4575



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 43/197 (21%), Positives = 88/197 (44%), Gaps = 12/197 (6%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P  F++   + S++ G    ++   +G P   VSW  +   +   +   + ++EK   S 
Sbjct: 6926 PATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEK---ST 6982

Query: 309  IFEVVRAS--DAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSV 366
            I E++ ++  D   Y+C+ +N AG+      + VL       P FI   +  + + G+  
Sbjct: 6983 ILEILESTIEDYAQYSCLIENEAGQDICEALVSVL-----EPPYFIEPLEHVEAVIGEPA 7037

Query: 367  KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAV 426
             L+C++   P  ++ W + +  ++        +++N    +L+I  V+  D G Y+  A 
Sbjct: 7038 TLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNV--ASLVINKVDHSDVGEYSCKAD 7095

Query: 427  NEAGVTTCNTRLDVTAR 443
            N  G    +  L + AR
Sbjct: 7096 NSVGAVASSAVLVIKAR 7112



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 62/264 (23%), Positives = 108/264 (40%), Gaps = 44/264 (16%)

Query: 235  GDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD 294
            GD+ D++  Q+ F+  +   +           CR+     G P   V W  +G+ +++ +
Sbjct: 1692 GDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLT--PIGDPTMVVEWLHDGKPLEAAN 1749

Query: 295  LHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAG----EATFTV-------------- 336
              +MI +E G  SL + V  + D+G   C A N+ G     AT  V              
Sbjct: 1750 RLRMI-NEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPE 1808

Query: 337  ---------QLDVLAKE-----------HKRAPMFIYKPQSKKVLEGDSVKLECQISAIP 376
                     +L+ +A E            K+ P  +  P+  +VLEG++ +  C+++  P
Sbjct: 1809 GRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYP 1868

Query: 377  PPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
             PK+ W  N ++++  + R  +  D  G   L I D    D G   V+A N  GV     
Sbjct: 1869 QPKVNWYLNGQLIR-KSKRFRVRYD--GIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKV 1925

Query: 437  RLDVTARPNQTLPAPKQLRVRPTF 460
            +L++  R +      +    RP F
Sbjct: 1926 KLEIQQREDFRSVLRRAPEPRPEF 1949



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 46/166 (27%), Positives = 79/166 (47%), Gaps = 13/166 (7%)

Query: 258   NMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASD 317
             N+ + E    ++  +VS  P  +V WY     +     ++ I++E     L+ +     D
Sbjct: 12471 NIEVSETDTIKLVCEVSK-PGAEVIWYKGDEEIIETGRYE-ILTEGRKRILVIQNAHLED 12528

Query: 318   AGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPP 377
             AG Y C   +         + D   K H+ A  FI KPQ+ ++LEG+  +  C IS    
Sbjct: 12529 AGNYNCRLPSS--------RTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESF 12580

Query: 378   PKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTV 423
             P + WKR+++ ++ + D+  +  D   RV L++KD   +D G Y V
Sbjct: 12581 P-VQWKRDDKTLE-SGDKYDVIADGKKRV-LVVKDATLQDMGTYVV 12623



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 50/208 (24%), Positives = 90/208 (43%), Gaps = 8/208 (3%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P + I+  E + +  G    +++ V+G P     WY +GR + +   ++ I  +  +  L
Sbjct: 4016 PAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYR-ISFKNNVAQL 4074

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
             F      D+G Y     N  G ++      VL ++   AP F    ++   +   + +L
Sbjct: 4075 KFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDI--APFFTKPLRNVDSVVNGTCRL 4132

Query: 369  ECQISAIPPPKLFW-KRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
            +C+I+   P ++ W K   E+   +  RI+  +   G  +L I  V+  DAG +T  A N
Sbjct: 4133 DCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVE---GTASLEIIRVDMNDAGNFTCRATN 4189

Query: 428  EAGVTTCNTRLDVTARPN-QTLPAPKQL 454
              G    +  L V   P+  T P  K +
Sbjct: 4190 SVGSKDSSGALIVQEPPSFVTKPGSKDV 4217



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 58/217 (26%), Positives = 87/217 (40%), Gaps = 15/217 (6%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP FI+  E+ S   G        + G     V+W  +   +  DD  +M   E  + SL
Sbjct: 4485 PPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTF-ENNVASL 4543

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
                +     G Y C AKN AG    +  L V     K       +  S  V +GD   L
Sbjct: 4544 YLSGIEVKHDGKYVCQAKNDAGIQRCSALLSV-----KEPATITEEAVSIDVTQGDPATL 4598

Query: 369  ECQISAIPPPKLFW-KRNNEMVQFNTDRISLYQDNTGRVTLL-IKDVNKKDAGWYTVSAV 426
            + + S        W K   E+   +  +IS+    T  V++L I    KKD+G YT    
Sbjct: 4599 QVKFSGTKEITAKWFKDGQELTLGSKYKISV----TDTVSILKIISTEKKDSGEYTFEVQ 4654

Query: 427  NEAGVTTCNTR---LDVTARPNQTLPAPKQLRVRPTF 460
            N+ G ++C  R   LD+   P+ T    K   ++ +F
Sbjct: 4655 NDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSF 4691



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 1/125 (0%)

Query: 250   PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
             P FI  P + +I+EG+      ++SG P+P++ W+ N   + S   +  I   + ++SL 
Sbjct: 33134 PAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPI-SISSNVSISRSRNVYSLE 33192

Query: 310   FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLE 369
                   SD+G Y   AKN  G+ + T  L VL    + +   + +      L+G      
Sbjct: 33193 IRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQS 33252

Query: 370   CQISA 374
              Q+SA
Sbjct: 33253 VQMSA 33257



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 35/102 (34%), Positives = 50/102 (49%), Gaps = 3/102 (2%)

Query: 347 RAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV 406
           +AP F    QS  VLEG +   E  IS  P P++ W R+ +++  +T        + GR 
Sbjct: 4   QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63

Query: 407 TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV---TARPN 445
            L I  V K ++G Y++ A N +G  T    L V   TA PN
Sbjct: 64  KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPN 105



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 33/129 (25%), Positives = 63/129 (48%), Gaps = 8/129 (6%)

Query: 325   AKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSK----KVLEGDSVKLECQISAIPPPKL 380
             A N  GE+  ++ L+V+ ++ +  P    +   +    KV  G+ V +   ++ +P PK+
Sbjct: 15371 AVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKI 15430

Query: 381   FWKRNNEMVQFNTDRISLYQDNTGR----VTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
              W +N  +++  TD + + ++   R      L I    ++D G YTV+A N  G    N 
Sbjct: 15431 EWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNV 15490

Query: 437   RLDVTARPN 445
              ++V  RP+
Sbjct: 15491 HVEVYDRPS 15499



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 38/158 (24%), Positives = 66/158 (41%), Gaps = 4/158 (2%)

Query: 191  GPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPP 250
            G  + +A    +D+    +  Q       LQ    +   R    G +      Q++   P
Sbjct: 1784 GTDHTSATLIVKDEKSLVEESQLPEGRKGLQ--RIEELERMAHEGALTGVTTDQKEKQKP 1841

Query: 251  RFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
              +  PE + + EG   R   +V+G P P V+WYLNG+ ++     +  V   G+H L  
Sbjct: 1842 DIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKS--KRFRVRYDGIHYLDI 1899

Query: 311  EVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRA 348
               ++ D G     A+N  G     V+L++  +E  R+
Sbjct: 1900 VDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRS 1937



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 43/153 (28%), Positives = 68/153 (44%), Gaps = 11/153 (7%)

Query: 301   SEKGLHSLIFEVVRASDAGAYACVAK--NRAGEATFTVQLDVLAKEHKRAPMFIYKPQSK 358
             +++ +  L F V    + G Y    K  N AG +  +  +     +    P  I   +  
Sbjct: 16067 NKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFM 16126

Query: 359   KVLEGDSVKLECQISAIPPPKLFWKR-------NNEMVQFNTDRISLYQDNTGRVTLLIK 411
             +V EG +V +  +I  +P P L W +       N E V ++T    L  D+T   TL+I 
Sbjct: 16127 EVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDT--CTLVIP 16184

Query: 412   DVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARP 444
                + D G YT++AVN  G  +   RL+V  RP
Sbjct: 16185 QSRRSDTGLYTITAVNNLGTASKEMRLNVLGRP 16217



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 48/162 (29%), Positives = 72/162 (44%), Gaps = 11/162 (6%)

Query: 277  PAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTV 336
            P   V WY +G  V   D ++M  S++ +H L    +  SDA  Y+CV        T T 
Sbjct: 2201 PFVKVKWYKDGMEVHEGDKYRMH-SDRKVHFLSILTIDTSDAEDYSCVLVEDENVKT-TA 2258

Query: 337  QLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRI 396
            +L V          F+ + Q  +V E  S +LEC +S   P  +  K  +  V+  ++  
Sbjct: 2259 KLIV----EGAVVEFVKELQDIEVPESYSGELECIVS---PENIEGKWYHNDVELKSNGK 2311

Query: 397  SLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 438
                   GR  L +KDV K+D G Y  S V +   TTC  ++
Sbjct: 2312 YTITSRRGRQNLTVKDVTKEDQGEY--SFVIDGKKTTCKLKM 2351



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 40/147 (27%), Positives = 71/147 (48%), Gaps = 3/147 (2%)

Query: 299   IVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQ-LDVLAKEHKRAPMFIYKPQS 357
             IV+E  + + +   + +     +   A N  G++   V  + V+AK+    P       +
Sbjct: 24261 IVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNT 24320

Query: 358   KKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKD 417
               +  G+ +K+E  +   P P + W ++ E ++  T R+++ +  T  V L IK+ NK D
Sbjct: 24321 YSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLK-QTTRVNVEETATSTV-LHIKEGNKDD 24378

Query: 418   AGWYTVSAVNEAGVTTCNTRLDVTARP 444
              G YTV+A N AG  T N  + V  +P
Sbjct: 24379 FGKYTVTATNSAGTATENLSVIVLEKP 24405



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 32/143 (22%), Positives = 67/143 (46%), Gaps = 2/143 (1%)

Query: 307   SLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSV 366
             SL+   ++      +   A+N  G +       V   + +  P  I  P+   +  G  +
Sbjct: 18857 SLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKL 18916

Query: 367   KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAV 426
             ++E  +   P P   WK+  + V   +  +++++ ++  + L+IKDV +KD+G+Y+++A 
Sbjct: 18917 RIEAHVYGKPHPTCKWKKGEDEV-VTSSHLAVHKADSSSI-LIIKDVTRKDSGYYSLTAE 18974

Query: 427   NEAGVTTCNTRLDVTARPNQTLP 449
             N +G  T   ++ V   P    P
Sbjct: 18975 NSSGTDTQKIKVVVMDAPGPPQP 18997



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 45/170 (26%), Positives = 74/170 (43%), Gaps = 15/170 (8%)

Query: 257  ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRAS 316
            +++++ EG+ C M  + S +P     W+ NGR ++    HK  V  K +H L    VRA 
Sbjct: 8752 QDVTLKEGQTCTMTCQFS-VPNVKSEWFRNGRILKPQGRHKTEVEHK-VHKLTIADVRAE 8809

Query: 317  DAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIP 376
            D G Y C  ++    A   ++ + +         F  + Q+  V E  S   EC++S   
Sbjct: 8810 DQGQYTCKYEDLETSAELRIEAEPI--------QFTKRIQNIVVSEHQSATFECEVSFDD 8861

Query: 377  PPKLFWKRNNEMVQFNTDRISLYQDNTGRV-TLLIKDVNKKDAGWYTVSA 425
                ++K   E+    T+       N GR   + I +V   D G Y+V A
Sbjct: 8862 AIVTWYKGPTEL----TESQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIA 8907



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 28/93 (30%), Positives = 46/93 (49%), Gaps = 1/93 (1%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKM-IVSEKGLHS 307
             PP+   +P ++SIDEG+   +    +G P P+V+W   GR + S +  +  I +   L +
Sbjct: 33328 PPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTT 33387

Query: 308   LIFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
             LI   V+  D G Y     N  G  + TV + +
Sbjct: 33388 LIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 33420



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 34/117 (29%), Positives = 55/117 (47%), Gaps = 5/117 (4%)

Query: 236  DVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDL 295
            D+++ +A++  F   R     +N  I EG       K+SG P P ++WY +G+ ++  + 
Sbjct: 1282 DISESEAVESGF-DSRI----KNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGER 1336

Query: 296  HKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFI 352
            ++M   + G  SL   VV   D G Y   A N  G A  + +L V       AP +I
Sbjct: 1337 YQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYI 1393



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 48/189 (25%), Positives = 83/189 (43%), Gaps = 14/189 (7%)

Query: 244   QEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVS---WYLNGRTVQSDDLHKMIV 300
             Q K  P +F++  +++ + E  F         L +P  +   W  +G  ++    H+ I 
Sbjct: 11109 QLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSPSTAITTWMKDGSNIRESPKHRFIA 11168

Query: 301   SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKK- 359
               K     I +V + SDAG Y CV +    E T T +L V     +  P+   K   ++ 
Sbjct: 11169 DGKDRKLHIIDV-QLSDAGEYTCVLRLGNKEKTSTAKLVV-----EELPVRFVKTLEEEV 11222

Query: 360   -VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
              V++G  + L C+++      + W+++ ++V     RI        R  L I D +  DA
Sbjct: 11223 TVVKGQPLYLSCELN--KERDVVWRKDGKIVVEKPGRIVPGVIGLMR-ALTINDADDTDA 11279

Query: 419   GWYTVSAVN 427
             G YTV+  N
Sbjct: 11280 GTYTVTVEN 11288



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 48/179 (26%), Positives = 73/179 (40%), Gaps = 14/179 (7%)

Query: 252   FIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFE 311
             FI  P+N+ I EG        +S    P V W  + +T++S D + +I   K    L+ +
Sbjct: 12554 FISKPQNLEILEGEKAEFVCSISKESFP-VQWKRDDKTLESGDKYDVIADGKK-RVLVVK 12611

Query: 312   VVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQ 371
                  D G Y  +     G A     L V+ K     P+     +  +V E   V   C+
Sbjct: 12612 DATLQDMGTYVVMV----GAARAAAHLTVIEKLRIVVPL-----KDTRVKEQQEVVFNCE 12662

Query: 372   ISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
             ++     K  W RN E +  ++  I L +D     TL I+D +  D   Y VS  N  G
Sbjct: 12663 VNT-EGAKAKWFRNEEAIFDSSKYIILQKDLV--YTLRIRDAHLDDQANYNVSLTNHRG 12718



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 34/133 (25%), Positives = 64/133 (48%), Gaps = 10/133 (7%)

Query: 251   RFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
             R +  P +M++ EG   R      G P P V+W   G+ + +   H++  ++   +   F
Sbjct: 32562 RILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTK---YKSTF 32618

Query: 311   EV--VRASDAGAYACVAKNRAG----EATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGD 364
             E+  V+ASD G Y+ V +N  G    E T T+Q   + ++   +P  +  P+  +V   +
Sbjct: 32619 EISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPE-PRVKSPE 32677

Query: 365   SVKLECQISAIPP 377
             +VK   ++ +  P
Sbjct: 32678 AVKSPKRVKSPEP 32690



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 45/200 (22%), Positives = 85/200 (42%), Gaps = 17/200 (8%)

Query: 256   PENMSI-DEGR------FCRMDFKVSGLPAPDVSWYLNGRTVQSDD---LHKMIVSEKGL 305
             PEN+ I D+G+      + R D+      +P++S+++  R   SDD   +HK  + E   
Sbjct: 18104 PENLHIADKGKTFVYLKWRRPDYDGG---SPNLSYHVERRLKGSDDWERVHKGSIKET-- 18158

Query: 306   HSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE-GD 364
             H ++   V  +    +    KN  GE+ +    +V+ KE  + P+   K      ++ GD
Sbjct: 18159 HYMVDRCVE-NQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGD 18217

Query: 365   SVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVS 424
             +++LE  +   P P++ W ++ +                      +    + D G Y V+
Sbjct: 18218 TIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVT 18277

Query: 425   AVNEAGVTTCNTRLDVTARP 444
             A N AG       ++V  +P
Sbjct: 18278 ATNTAGSFVAYATVNVLDKP 18297



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 50/182 (27%), Positives = 83/182 (45%), Gaps = 21/182 (11%)

Query: 257   ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG-LHSLIFEVVRA 315
             +++++  G     D ++S    P V WYL G+ ++  D  K++   +G +H+L    V+ 
Sbjct: 12203 KDVTVTAGETATFDCELSYEDIP-VEWYLKGKKLEPSD--KVVPRSEGKVHTLTLRDVKL 12259

Query: 316   SDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKP-QSKKVLEGDSVKLECQISA 374
              DAG     AK+    A   V         K  P+   KP + + V EG +  LEC++S 
Sbjct: 12260 EDAGEVQLTAKDFKTHANLFV---------KEPPVEFTKPLEDQTVEEGATAVLECEVSR 12310

Query: 375   IPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV-TLLIKDVNKKDAGWYTVSAVNEAGVTT 433
                 K+ W +N   +   + +  +  D  GRV  L+I D   +D   YT  A +    T+
Sbjct: 12311 -ENAKVKWFKNGTEI-LKSKKYEIVAD--GRVRKLVIHDCTPEDIKTYTCDAKDFK--TS 12364

Query: 434   CN 435
             CN
Sbjct: 12365 CN 12366



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 33/111 (29%), Positives = 55/111 (49%), Gaps = 8/111 (7%)

Query: 235   GDVNDQDAIQEKFYPPRF---IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTV- 290
             G+V D   ++++   P       V + + +  G   R+   VSG P P V+W +N RT+ 
Sbjct: 16507 GEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLP 16566

Query: 291   QSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
             Q   +    +S     S++ +  + S  G Y+ +AKN AGE   T+ +DVL
Sbjct: 16567 QEATIETTAISS----SMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVL 16613



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 62/269 (23%), Positives = 101/269 (37%), Gaps = 46/269 (17%)

Query: 166  KCKDTLLHNGNQRLTYEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTS 225
            K KD LLH   + LT EEK A                            +E  ++ +PT 
Sbjct: 2033 KTKDELLH-WTKELTEEEKKAL---------------------------AEEGKITIPTF 2064

Query: 226  QVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYL 285
            +            D+  +      P+  +  ++ ++ +G       +V G P P+  WY 
Sbjct: 2065 KP-----------DKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYK 2113

Query: 286  NGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEH 345
            NG  ++  D       E  +  L+   V A D+ +    A N AGE +    L V AK+ 
Sbjct: 2114 NGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQ- 2172

Query: 346  KRAPMFIYKPQSKKVLEGDSV-KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTG 404
                 F  + Q     E D++   EC+ S  P  K+ W ++  M     D+  ++ D   
Sbjct: 2173 --LITFTQELQDVVAKEKDTMATFECETSE-PFVKVKWYKDG-MEVHEGDKYRMHSDRKV 2228

Query: 405  RVTLLIKDVNKKDAGWYTVSAVNEAGVTT 433
               L I  ++  DA  Y+   V +  V T
Sbjct: 2229 HF-LSILTIDTSDAEDYSCVLVEDENVKT 2256



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 32/114 (28%), Positives = 56/114 (49%), Gaps = 3/114 (2%)

Query: 359  KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
            ++LEG  V   C++S  P PK+ W ++ + ++ + +R  +     GR +L I  V  +D 
Sbjct: 1301 RILEGMGVTFHCKMSGYPLPKIAWYKDGKRIK-HGERYQMDFLQDGRASLRIPVVLPEDE 1359

Query: 419  GWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLN 472
            G YT  A N  G   C+ +L V   P   L AP  +      S+  +L+ + ++
Sbjct: 1360 GIYTAFASNIKGNAICSGKLYV--EPAAPLGAPTYIPTLEPVSRIRSLSPRSVS 1411



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 30/82 (36%), Positives = 42/82 (51%), Gaps = 2/82 (2%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G    ++  IS  P PK+ WK   EM    TDR+S+      R TL +KD  + D+G Y 
Sbjct: 28662 GSPFTIDVPISGRPAPKVTWKLE-EMRLKETDRVSI-TTTKDRTTLTVKDSMRGDSGRYF 28719

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             ++  N AGV T +  + V  RP
Sbjct: 28720 LTLENTAGVKTFSVTVVVIGRP 28741



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 42/141 (29%), Positives = 74/141 (52%), Gaps = 14/141 (9%)

Query: 283  WYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLA 342
            WY N   ++S+  +  I S +G  +L  + V   D G Y+ V   +  + T  +++    
Sbjct: 2299 WYHNDVELKSNGKYT-ITSRRGRQNLTVKDVTKEDQGEYSFVIDGK--KTTCKLKM---- 2351

Query: 343  KEHKRAPMFIYKPQS-KKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQD 401
               K  P+ I +  S +KV EGD V+LE ++S +   +  W ++ + VQ  +DR+ +  D
Sbjct: 2352 ---KPRPIAILQGLSDQKVCEGDIVQLEVKVS-LESVEGVWMKDGQEVQ-PSDRVHIVID 2406

Query: 402  NTGRVTLLIKDVNKKDAGWYT 422
                + LLI+D+ K+DAG Y+
Sbjct: 2407 KQSHM-LLIEDMTKEDAGNYS 2426



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 41/178 (23%), Positives = 79/178 (44%), Gaps = 15/178 (8%)

Query: 251  RFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
            + I+ P++++  E      +  VS    P V W+     ++  D H++ VSE+ +H L+ 
Sbjct: 2796 KIIKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKSVEIKPSDKHRL-VSERKVHKLML 2853

Query: 311  EVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLEC 370
            + +  SDAG Y  V      +A   V+   + K  K     I  P++K      +   EC
Sbjct: 2854 QNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKN----IEVPETK------TASFEC 2903

Query: 371  QISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            ++S    P + W +N   ++ +     + Q    +  L+I + + +D+  YT    N+
Sbjct: 2904 EVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQ--LIIMNTSTEDSAEYTFVCGND 2958



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 40/148 (27%), Positives = 68/148 (45%), Gaps = 12/148 (8%)

Query: 225   SQVRSRSTSRGDVN--------DQDAIQEKFYPPRF---IQVPENMSIDEGRFCRMDFKV 273
             +Q + R+ +R  VN        D   I  +  PPR    + +   +++  G    +D  V
Sbjct: 19260 AQYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATV 19319

Query: 274   SGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEAT 333
              G P P VSW  +G  ++  +  KM + ++ L +L    V   D+G Y   A+N +G  +
Sbjct: 19320 FGKPMPTVSWKKDGTLLKPAEGIKMAM-QRNLCTLELFSVNRKDSGDYTITAENSSGSKS 19378

Query: 334   FTVQLDVLAKEHKRAPMFIYKPQSKKVL 361
              T++L VL K    A + I K  S + +
Sbjct: 19379 ATIKLKVLDKPGPPASVKINKMYSDRAM 19406



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 34/123 (27%), Positives = 59/123 (47%), Gaps = 6/123 (4%)

Query: 325   AKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAIPPPKLF 381
             A+N  GE T + ++ V+A++   AP    K          E  + +L+  I   P P + 
Sbjct: 19957 AENENGEGTPS-EITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVS 20015

Query: 382   WKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVT 441
             WK+  + +  +T R+S+ + +    TL++ D  K DAG YT++  N AG       + V 
Sbjct: 20016 WKKGEDPLATDT-RVSV-ESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVV 20073

Query: 442   ARP 444
              +P
Sbjct: 20074 GKP 20076



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 49/180 (27%), Positives = 84/180 (46%), Gaps = 25/180 (13%)

Query: 250  PRFIQVPENMS---IDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQ-SDDLHKMIVSEKGL 305
            PR I + + +S   + EG   +++ KVS L + +  W  +G+ VQ SD +H  IV +K  
Sbjct: 2353 PRPIAILQGLSDQKVCEGDIVQLEVKVS-LESVEGVWMKDGQEVQPSDRVH--IVIDKQS 2409

Query: 306  HSLIFEVVRASDAGAYA----CVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL 361
            H L+ E +   DAG Y+     +  + +G  +    +DV+       P+     +   V+
Sbjct: 2410 HMLLIEDMTKEDAGNYSFTIPALGLSTSGRVS-VYSVDVIT------PL-----KDVNVI 2457

Query: 362  EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWY 421
            EG    LEC++S      + W  N+E ++   DR+      T +  L+I   +  D G Y
Sbjct: 2458 EGTKAVLECKVSVPDVTSVKWYLNDEQIK-PDDRVQAIVKGT-KQRLVINRTHASDEGPY 2515



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 28/96 (29%), Positives = 46/96 (47%), Gaps = 1/96 (1%)

Query: 348  APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
            AP    + QS+ V +G       ++   P P+  W +N   ++  +DRI  Y        
Sbjct: 2077 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIE-RSDRIYWYWPEDNVCE 2135

Query: 408  LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTAR 443
            L+I+DV  +D+    V A+N AG T+ +  L V A+
Sbjct: 2136 LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAK 2171



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 41/174 (23%), Positives = 71/174 (40%), Gaps = 19/174 (10%)

Query: 263   EGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYA 322
             EG    +      +P P VSW+ +G+ V++ D   M       H  + + VRA DAG Y 
Sbjct: 14400 EGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRA-DAGIYT 14458

Query: 323   CVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPP----- 377
                +N+ G AT ++ + V+                K +   D  K  C+++  PP     
Sbjct: 14459 ITLENKLGSATASINVKVIG----------LPGPCKDIKASDITKSSCKLTWEPPEFDGG 14508

Query: 378   -PKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
              P L +          T    +  +N  +++  +KD+      ++ V AVN+ G
Sbjct: 14509 TPILHYVLERREAGRRTYIPVMSGEN--KLSWTVKDLIPNGEYFFRVKAVNKVG 14560



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 24/86 (27%), Positives = 45/86 (52%), Gaps = 2/86 (2%)

Query: 359   KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
             K   G SVKL   IS  P P + W ++++ +Q  T+ +   ++ T   ++LIKD ++ ++
Sbjct: 26883 KYRAGTSVKLRAGISGKPAPTIEWYKDDKELQ--TNALVCVENTTDLASILIKDADRLNS 26940

Query: 419   GWYTVSAVNEAGVTTCNTRLDVTARP 444
             G Y +   N  G  +   R+ +  +P
Sbjct: 26941 GCYELKLRNAMGSASATIRVQILDKP 26966



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 52/193 (26%), Positives = 79/193 (40%), Gaps = 18/193 (9%)

Query: 251   RFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
             +F+   E+ ++ EG       ++S      V W+ N   + +     +I SE   H L  
Sbjct: 11575 KFMSPLEDQTVKEGETATFVCELSH-EKMHVVWFKNDAKLHTSRT-VLISSEGKTHKLEM 11632

Query: 311   EVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLEC 370
             + V   D        K    E + T QL VL  +    P F  K   K  +E D + L+C
Sbjct: 11633 KEVTLDDISQIKAQVK----ELSSTAQLKVLEAD----PYFTVKLHDKTAVEKDEITLKC 11684

Query: 371   QISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
             ++S   P K F K   E+V   + + S+  D   R+ L IK  + KD G Y    V + G
Sbjct: 11685 EVSKDVPVKWF-KDGEEIVP--SPKYSIKADGLRRI-LKIKKADLKDKGEY----VCDCG 11736

Query: 431   VTTCNTRLDVTAR 443
                    + V AR
Sbjct: 11737 TDKTKANVTVEAR 11749



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 27/101 (26%), Positives = 43/101 (42%), Gaps = 4/101 (3%)

Query: 244   QEKFYPPRF---IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIV 300
             QEK  PP     +++ E + +  G   R    + G+P P   W  +G  +++D+ H  + 
Sbjct: 17502 QEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDE-HYTVE 17560

Query: 301   SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
             ++     L  +     D G Y     N AG  T  V L VL
Sbjct: 17561 TDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVL 17601



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 36/144 (25%), Positives = 67/144 (46%), Gaps = 4/144 (2%)

Query: 303   KGLHSLIFEVVRASDAGAYACVAKNRAGEAT-FTVQLDVLAKEHKRAPMFIYKPQSKKVL 361
             K L ++I  + +  +   +  VA N  G +   ++ + ++AK+    P       S  V 
Sbjct: 23184 KSLQAVITNLTQGEEY-LFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQ 23242

Query: 362   EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWY 421
              G  +K+E  IS  P P + W ++   ++  T RI++  D+    TL IK+ +K D G Y
Sbjct: 23243 VGQDLKIEVPISGRPKPTITWTKDGLPLK-QTTRINV-TDSLDLTTLSIKETHKDDGGQY 23300

Query: 422   TVSAVNEAGVTTCNTRLDVTARPN 445
              ++  N  G  T +  +    +P+
Sbjct: 23301 GITVANVVGQKTASIEIVTLDKPD 23324



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 27/106 (25%), Positives = 53/106 (50%), Gaps = 2/106 (1%)

Query: 339   DVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISL 398
             +V+AK+    P    +     V+EG+ + +     A+P P + W ++ + V+  +DR+++
Sbjct: 14377 NVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVK-ASDRLTM 14435

Query: 399   YQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARP 444
               D+      + K V + DAG YT++  N+ G  T +  + V   P
Sbjct: 14436 KNDHISAHLEVPKSV-RADAGIYTITLENKLGSATASINVKVIGLP 14480



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 44/180 (24%), Positives = 77/180 (42%), Gaps = 19/180 (10%)

Query: 321   YACVAKNRAGEATFTVQLD----VLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQIS 373
             +  +A+N AG   F+   D    + A++   AP     P+ K V+    G++  LE  I 
Sbjct: 24675 FRVIARNAAGN--FSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIR 24732

Query: 374   AIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTT 433
               P P + W ++ + ++    R+ + +    + TL++KD  + D G Y +   N  G  +
Sbjct: 24733 GKPIPDVVWSKDGKELEETAARMEI-KSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKS 24791

Query: 434   CNTRLDVTARPNQTLPAPKQLRVRPTFSK--YLA----LNGKGLNVKQAFNPEGEFQRLA 487
                 + V  RP    P    L+V    ++  YLA    L   G N+      + E  RL+
Sbjct: 24792 IPITVKVLDRPG---PPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLS 24848



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 51/200 (25%), Positives = 85/200 (42%), Gaps = 25/200 (12%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
             P  F++  E+ ++ E        ++S   A +V WY NGR ++    +K    +  +H L
Sbjct: 12822 PTEFVEHLEDQTVTEFDDAVFSCQLSREKA-NVKWYRNGREIKEGKKYKF-EKDGSIHRL 12879

Query: 309   IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL---EGDS 365
             I +  R  D   YAC  ++R   A   V  + +  E  R P  I +     V+   E + 
Sbjct: 12880 IIKDCRLDDECEYACGVEDRKSRARLFV--EEIPVEIIRPPQDILEAPGADVVFLAELNK 12937

Query: 366   VKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV-TLLIKDVNKKDAGWYTVS 424
              K+E Q          W RNN MV    D+  +  +  G++  L I D+  +D G Y   
Sbjct: 12938 DKVEVQ----------WLRNN-MVVVQGDKHQMMSE--GKIHRLQICDIKPRDQGEYRFI 12984

Query: 425   AVNEAGVTTCNTRLDVTARP 444
             A ++        +L++ A P
Sbjct: 12985 AKDK----EARAKLELAAAP 13000



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 32/135 (23%), Positives = 64/135 (47%), Gaps = 6/135 (4%)

Query: 299   IVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSK 358
             I + KGL  ++  +    +   +  +A N AG +       V+ KE    P    +   +
Sbjct: 21014 ITTVKGLECVVRNLTEGEEY-TFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQ 21072

Query: 359   KVL---EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNK 415
             K++    GD++K+E  +   P P + WK+ +++++  T R++     T  + L I +  +
Sbjct: 21073 KLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILK-QTQRVNFETTATSTI-LNINECVR 21130

Query: 416   KDAGWYTVSAVNEAG 430
              D+G Y ++A N  G
Sbjct: 21131 SDSGPYPLTARNIVG 21145



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 29/102 (28%), Positives = 50/102 (49%), Gaps = 10/102 (9%)

Query: 250   PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYL-------NGRTVQSD-DLHKMIVS 301
             P  I + E M ++EG    +  K+ G+P P ++W+        N   V  D  ++K++V 
Sbjct: 16117 PPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVD 16176

Query: 302   EKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
             +    +L+    R SD G Y   A N  G A+  ++L+VL +
Sbjct: 16177 D--TCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGR 16216



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 34/128 (26%), Positives = 56/128 (43%), Gaps = 8/128 (6%)

Query: 325   AKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSK---KVLEGDSVKLECQISAIPPPKLF 381
             A N AGE        V   E +  P        K   +++ G ++++   ++  P P   
Sbjct: 15078 AVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKV 15137

Query: 382   WKRNNEMVQFNTDRISLYQDNTG-RVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
             W +  E  + + DR+ +  DN G +  L+IKD  +KD G Y ++A N  G      R++V
Sbjct: 15138 WTK--EEGELDKDRVVI--DNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEV 15193

Query: 441   TARPNQTL 448
                P   L
Sbjct: 15194 FDVPGPVL 15201



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 52/193 (26%), Positives = 78/193 (40%), Gaps = 23/193 (11%)

Query: 277   PAPDVSWYLNGRTVQSDDLHK---MIVSEKGLHSLIFEVVRASDAGAYA--CVAKNRAG- 330
             P  D    L G  V+  DL     M  +   +    F V    + G Y     AKN AG 
Sbjct: 20297 PKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGA 20356

Query: 331   -----EATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE---GDSVKLEC-QISAIPPPKLF 381
                  E+T T+    + K+   AP  +  P  K  L    GD++ L    I   P PK  
Sbjct: 20357 ISAPSESTETI----ICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSS 20412

Query: 382   WKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVT 441
             W +  + ++  +D   +    T  + L IK   +KDAG YT++A N  G    + ++ V 
Sbjct: 20413 WSKAGKDIR-PSDITQITSTPTSSM-LTIKYATRKDAGEYTITATNPFGTKVEHVKVTVL 20470

Query: 442   ARPNQTLPAPKQL 454
               P    P P ++
Sbjct: 20471 DVPGP--PGPVEI 20481



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 28/99 (28%), Positives = 46/99 (46%), Gaps = 2/99 (2%)

Query: 243   IQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSE 302
             +  K + P+ ++    +    G    +    SG P P ++W   G+ +  ++ H  ++  
Sbjct: 31021 VPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQ-KGQDLIDNNGHYQVIVT 31079

Query: 303   KGLHSLIF-EVVRASDAGAYACVAKNRAGEATFTVQLDV 340
             +   SL+F   V   DAG Y   AKNR G    TV+LDV
Sbjct: 31080 RSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDV 31118



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 40/169 (23%), Positives = 63/169 (37%), Gaps = 8/169 (4%)

Query: 178  RLTYEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDV 237
            R  + E   R      N A           Q S++   E   +    +    R     DV
Sbjct: 1003 REAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDV 1062

Query: 238  --NDQDAIQEKFYP-----PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTV 290
               D    +E+  P     P FI  P    + EG       +V G P P V W  +G  +
Sbjct: 1063 VMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPL 1122

Query: 291  QSDDLHKMIVSEK-GLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQL 338
             +   +K+  +++ G   L+  +  A DAG Y  V +N+ GE + +  L
Sbjct: 1123 TTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 28/108 (25%), Positives = 48/108 (44%), Gaps = 2/108 (1%)

Query: 244   QEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEK 303
             +E+  PP+ + +PE ++I  G+  R++  V G P P   W   G        H  +    
Sbjct: 18894 KEQLLPPKIL-MPEQITIKAGKKLRIEAHVYGKPHPTCKW-KKGEDEVVTSSHLAVHKAD 18951

Query: 304   GLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMF 351
                 LI + V   D+G Y+  A+N +G  T  +++ V+       P F
Sbjct: 18952 SSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPF 18999



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 27/102 (26%), Positives = 49/102 (48%), Gaps = 6/102 (5%)

Query: 360   VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
             V  G +V L+  +   P P + WK++  +++         Q N    TL +  VN+KD+G
Sbjct: 19307 VKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNL--CTLELFSVNRKDSG 19364

Query: 420   WYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFS 461
              YT++A N +G  +   +L V  +P      P  +++   +S
Sbjct: 19365 DYTITAENSSGSKSATIKLKVLDKPG----PPASVKINKMYS 19402



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 39/150 (26%), Positives = 63/150 (42%), Gaps = 17/150 (11%)

Query: 231   STSRGDVNDQDAIQEKFYPPRFIQVP---ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNG 287
             S S G +  +D +     PPR    P   + + +  G   ++D  + G P P + W + G
Sbjct: 22526 SESTGAITARDEVD----PPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQW-IKG 22580

Query: 288   RTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKR 347
                 S+     I S     SL  +     D+G Y   AKN AGE + TV + VL +    
Sbjct: 22581 DQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPG-- 22638

Query: 348   APMFIYKPQSKKVLEGDSVKLECQISAIPP 377
                    P+   V+ G + + +C ++  PP
Sbjct: 22639 ------PPEGPVVISGVTAE-KCTLAWKPP 22661



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 21/86 (24%), Positives = 36/86 (41%)

Query: 355   PQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVN 414
             P    + EG  + + C  +  P P++ W      +          ++     TL+I DV 
Sbjct: 33335 PSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQ 33394

Query: 415   KKDAGWYTVSAVNEAGVTTCNTRLDV 440
             K+D G YT+S  NE G  +    + +
Sbjct: 33395 KQDGGLYTLSLGNEFGSDSATVNIHI 33420



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 42/204 (20%), Positives = 72/204 (35%), Gaps = 37/204 (18%)

Query: 274   SGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAG--- 330
             S L A +V+WY +G+ ++ +   +   S  G + L    +  SD G Y C      G   
Sbjct: 32742 SVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSK 32801

Query: 331   -------------------------------EATFTVQLDVLAKEH-KRAPMFIYKPQSK 358
                                            E+T T + +  A E     P+ +   Q  
Sbjct: 32802 TNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDT 32861

Query: 359   KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
              V      K   + +  P P   W ++ + +     +  L +D  G   L I   +  D+
Sbjct: 32862 TVSSDSVAKFAVKATGEPRPTAIWTKDGKAIT-QGGKYKLSEDK-GGFFLEIHKTDTSDS 32919

Query: 419   GWYTVSAVNEAGVTTCNTRLDVTA 442
             G YT +  N AG  + + +L + A
Sbjct: 32920 GLYTCTVKNSAGSVSSSCKLTIKA 32943



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 30/129 (23%), Positives = 60/129 (46%), Gaps = 7/129 (5%)

Query: 321   YACVAKNRAGEATFTVQLD--VLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAI 375
             +  +AKN AG  +   +    +  ++   AP      + K  +    G++ +LE  +S  
Sbjct: 21429 FRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGR 21488

Query: 376   PPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCN 435
             PPP + W ++ + ++  T ++ +   +     L+ KD  ++D+G YT++A N  G     
Sbjct: 21489 PPPTMEWSKDGKELE-GTAKLEIKIADFS-TNLVNKDSTRRDSGAYTLTATNPGGFAKHI 21546

Query: 436   TRLDVTARP 444
               + V  RP
Sbjct: 21547 FNVKVLDRP 21555



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 26/95 (27%), Positives = 45/95 (47%), Gaps = 2/95 (2%)

Query: 336   VQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDR 395
             + + V+AK+    P F     +  VL G+ +K++      P P + W ++N  ++  T R
Sbjct: 22135 LSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLK-QTTR 22193

Query: 396   ISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
             ++  +       L IKD  ++D G Y V   N AG
Sbjct: 22194 VNA-ESTENNSLLTIKDACREDVGHYVVKLTNSAG 22227



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 21/86 (24%), Positives = 38/86 (44%), Gaps = 1/86 (1%)

Query: 257   ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRAS 316
             ++ ++      +   K +G P P   W  +G+ +     +K+   +KG   L       S
Sbjct: 32859 QDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLS-EDKGGFFLEIHKTDTS 32917

Query: 317   DAGAYACVAKNRAGEATFTVQLDVLA 342
             D+G Y C  KN AG  + + +L + A
Sbjct: 32918 DSGLYTCTVKNSAGSVSSSCKLTIKA 32943



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 39/163 (23%), Positives = 66/163 (40%), Gaps = 16/163 (9%)

Query: 281   VSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
             V W+ N + + +     M   E   HS+ F+ +   D       A   + EA  TV    
Sbjct: 11959 VKWFKNDQRLHTTRSVSM-QDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVL--- 12014

Query: 341   LAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQ 400
                  +  P F  K Q    +E D V L+C+IS    P  ++K   E+      + ++ +
Sbjct: 12015 -----EGDPYFTGKLQDYTGVEKDEVILQCEISKADAPVKWFKDGKEI---KPSKNAVIK 12066

Query: 401   DNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTAR 443
              +  +  L++K   K D G YT     + G    + +LD+  R
Sbjct: 12067 ADGKKRMLILKKALKSDIGQYTC----DCGTDKTSGKLDIEDR 12105



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 32/142 (22%), Positives = 62/142 (43%), Gaps = 14/142 (9%)

Query: 306   HSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL---E 362
             H   F V+  + AG ++  +++            + A++    P     P+ K  +    
Sbjct: 22507 HRYEFRVIARNAAGVFSEPSESTGA---------ITARDEVDPPRISMDPKYKDTIVVHA 22557

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G+S K++  I   P P + W + ++ +  NT R+ +   +    +L +KD  + D+G Y 
Sbjct: 22558 GESFKVDADIYGKPIPTIQWIKGDQELS-NTARLEIKSTDFA-TSLSVKDAVRVDSGNYI 22615

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             + A N AG  +    + V  RP
Sbjct: 22616 LKAKNVAGERSVTVNVKVLDRP 22637



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 30/129 (23%), Positives = 58/129 (44%), Gaps = 7/129 (5%)

Query: 321   YACVAKNRAGEATFTVQLD--VLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAI 375
             +  +AKN AG  +        + AK+    P     P+ +  +    G++ +LE  +   
Sbjct: 23593 FRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGK 23652

Query: 376   PPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCN 435
             P P + W R ++ ++  + R  + ++   +  L++KD  + D G Y + A N AG  +  
Sbjct: 23653 PLPTIEWLRGDKEIE-ESARCEI-KNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFP 23710

Query: 436   TRLDVTARP 444
               + V  RP
Sbjct: 23711 VNVKVLDRP 23719



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 24/98 (24%), Positives = 41/98 (41%)

Query: 250   PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
             P F ++  N    EG+    + +VSG+P P + W  +G+ +      ++I      ++L 
Sbjct: 31795 PMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALH 31854

Query: 310   FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKR 347
                    D G Y   A N AG  +    L V    +K+
Sbjct: 31855 IRDTLPEDTGYYRVTATNTAGSTSCQAHLQVERLRYKK 31892



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 40/158 (25%), Positives = 61/158 (38%), Gaps = 13/158 (8%)

Query: 277  PAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTV 336
            P   V W  + + +Q  D  K I  EK +H L+    R SDAG Y  VA      A   V
Sbjct: 3084 PDITVQWMKDDQELQITDRIK-IQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFV 3142

Query: 337  Q-LDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDR 395
            +  DV  +  K+    I K ++    E +   ++            W ++   + F    
Sbjct: 3143 EGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAH----------WYKDGIEINFQVQE 3192

Query: 396  ISLYQDNTGRVTLLIKDVNKKDAGWYT-VSAVNEAGVT 432
               Y        + I +  + DAG YT V+  N + VT
Sbjct: 3193 RHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVT 3230



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 23/82 (28%), Positives = 42/82 (51%), Gaps = 2/82 (2%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G ++++  ++   P P + W +  +++     R+ L QD   RV L IK+  + D G Y 
Sbjct: 17923 GQTIRILARVKGRPEPDITWTKEGKVL-VREKRVDLIQD-LPRVELQIKEAVRADHGKYI 17980

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             +SA N +G    +  ++V  RP
Sbjct: 17981 ISAKNSSGHAQGSAIVNVLDRP 18002



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)

Query: 268   RMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKN 327
             R+   + G PAP VSW   G    + D    + S     +LI    + SDAG Y    KN
Sbjct: 20001 RLKIPIKGKPAPSVSWK-KGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKN 20059

Query: 328   RAGEATFTVQLDVLAK 343
              AG    T+ + V+ K
Sbjct: 20060 VAGTKEGTISIKVVGK 20075



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 21/91 (23%), Positives = 46/91 (50%), Gaps = 1/91 (1%)

Query: 253   IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEV 312
             ++  E +    G   ++   +SG PAP + WY + + +Q++ L   + +   L S++ + 
Sbjct: 26876 LEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNAL-VCVENTTDLASILIKD 26934

Query: 313   VRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
                 ++G Y    +N  G A+ T+++ +L K
Sbjct: 26935 ADRLNSGCYELKLRNAMGSASATIRVQILDK 26965



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 6/83 (7%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKD-VNKKDAGWY 421
             G S++L   +S  PPP + W +    +   +  I    D T   +LLI D VN+ DAG Y
Sbjct: 29461 GASLRLMVSVSGRPPPVITWSKQG--IDLASRAII---DTTESYSLLIVDKVNRYDAGKY 29515

Query: 422   TVSAVNEAGVTTCNTRLDVTARP 444
             T+ A N++G  +    + V   P
Sbjct: 29516 TIEAENQSGKKSATVLVKVYDTP 29538



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 23/85 (27%), Positives = 42/85 (49%), Gaps = 2/85 (2%)

Query: 360   VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
             V  G  ++L   ++  P PK+ W +  +M+     RI++ ++   + T+ I D  + D G
Sbjct: 13702 VKAGTKIELPATVTGKPEPKITWTKA-DMILKQDKRITI-ENVPKKSTVTIVDSKRSDTG 13759

Query: 420   WYTVSAVNEAGVTTCNTRLDVTARP 444
              Y + AVN  G  T    ++V  +P
Sbjct: 13760 TYIIEAVNVCGRATAVVEVNVLDKP 13784



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 36/140 (25%), Positives = 63/140 (45%), Gaps = 12/140 (8%)

Query: 321   YACVAKNRAGEATFT-VQLDVLAKEHKRAPMFIYKP---QSKKVLEGDSVKLECQISAIP 376
             +  +A N AGE+    V   VL K+    P  I      + + +  GD+++L   I  +P
Sbjct: 17187 FRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVP 17246

Query: 377   PPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
              PK+ WK+ +        RI +    +    L I++   +D G Y+++  N AG  T + 
Sbjct: 17247 FPKVTWKKEDRDAPTKA-RIDVTPVGS---KLEIRNAAHEDGGIYSLTVENPAGSKTVSV 17302

Query: 437   RLDVTARPNQTLPAPKQLRV 456
             ++ V  +P      P+ L V
Sbjct: 17303 KVLVLDKPG----PPRDLEV 17318



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 37/128 (28%), Positives = 62/128 (48%), Gaps = 14/128 (10%)

Query: 325   AKNRAGEAT-FTVQLDVLAKEHKRAP---MFIYKPQSKKVLEGDSVKLECQISAIPPPKL 380
             A+N+AG +    + L VL KE    P   M  +   +  V  G ++K++  IS  P PK+
Sbjct: 26449 AENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKV 26508

Query: 381   FWKRNN----EMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
                R+       ++FNT+   +  +N   +T+ +K+    DAG Y ++A N +G T    
Sbjct: 26509 TLSRDGVPLKATMRFNTE---ITAEN---LTINLKESVTADAGRYEITAANSSGTTKAFI 26562

Query: 437   RLDVTARP 444
              + V  RP
Sbjct: 26563 NIVVLDRP 26570



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 25/83 (30%), Positives = 42/83 (50%), Gaps = 1/83 (1%)

Query: 259   MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDA 318
             +++  G+  R+  +V G P PD++W   G+ +  +    +I     +   I E VRA D 
Sbjct: 17918 ITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRA-DH 17976

Query: 319   GAYACVAKNRAGEATFTVQLDVL 341
             G Y   AKN +G A  +  ++VL
Sbjct: 17977 GKYIISAKNSSGHAQGSAIVNVL 17999



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 56/245 (22%), Positives = 99/245 (40%), Gaps = 21/245 (8%)

Query: 106   DYNSSKIPSAMDSN---YQQSSAGQPINAKPSQ-TANAKPI--PRTPDHEIQGSKEALIQ 159
             +Y ++ +   +D     Y ++SAG    + PS+ T    P+  P TPD+ I  ++E +  
Sbjct: 27815 EYRATGLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDY-IDVTRETIT- 27872

Query: 160   DLERKLKCKDTLLHNGNQRLTY--EEKMARRLLGPQNAAAVFQAQDD-SGAQDSQQHNSE 216
                  LK    L   G++ + Y  E++         N   V + Q   +G     ++   
Sbjct: 27873 -----LKWNPPLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFR 27927

Query: 217   H-ARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSG 275
               AR  V T    S+S+      D++      + P +    + + I  G   R+   V G
Sbjct: 27928 IIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYF---DGLIIKSGESLRIKALVQG 27984

Query: 276   LPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFT 335
              P P V+W+ +G  ++   ++  I    G  SL          G Y   AKN +G A   
Sbjct: 27985 RPVPRVTWFKDGVEIEK-RMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAE 28043

Query: 336   VQLDV 340
             +++ V
Sbjct: 28044 IKVKV 28048



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 23/75 (30%), Positives = 37/75 (49%), Gaps = 1/75 (1%)

Query: 269   MDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNR 328
             +D  +SG PAP V+W L    ++  D    I + K   +L  +     D+G Y    +N 
Sbjct: 28667 IDVPISGRPAPKVTWKLEEMRLKETD-RVSITTTKDRTTLTVKDSMRGDSGRYFLTLENT 28725

Query: 329   AGEATFTVQLDVLAK 343
             AG  TF+V + V+ +
Sbjct: 28726 AGVKTFSVTVVVIGR 28740



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 42/153 (27%), Positives = 60/153 (39%), Gaps = 16/153 (10%)

Query: 276   LPAPDV--SWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEAT 333
             L  PDV   W L G+ + +    ++I   K  H LI    +    G  +  A N    A 
Sbjct: 11774 LSEPDVHGQWKLKGQPLTASPDCEIIEDGKK-HILILHNCQLGMTGEVSFQAANAKSAAN 11832

Query: 334   FTVQLDVLAKEHKRAPMFIYKPQSK-KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFN 392
               V         K  P+    P S  KV E D  K EC++S  P    + K   E+    
Sbjct: 11833 LKV---------KELPLIFITPLSDVKVFEKDEAKFECEVSREPKTFRWLKGTQEIT--G 11881

Query: 393   TDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSA 425
              DR  L +D T + +++IK    +D   Y   A
Sbjct: 11882 DDRFELIKDGT-KHSMVIKSAAFEDEAKYMFEA 11913



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 26/138 (18%), Positives = 62/138 (44%), Gaps = 9/138 (6%)

Query: 317   DAGAYACVAKNRAGEATFTVQLD--VLAKEHKRAPMFIYKPQ---SKKVLEGDSVKLECQ 371
             D   +  +A+N  G  +   Q    ++ ++    P+  + P+      +  G+S++++  
Sbjct: 27922 DRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKAL 27981

Query: 372   ISAIPPPKLFWKRNNEMVQFNTDRISL-YQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
             +   P P++ W ++   ++    R+++   D  G  +L ++D  +   G YTV A N +G
Sbjct: 27982 VQGRPVPRVTWFKDGVEIE---KRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASG 28038

Query: 431   VTTCNTRLDVTARPNQTL 448
                   ++ V   P + +
Sbjct: 28039 SAKAEIKVKVQDTPGKVV 28056



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 21/82 (25%), Positives = 41/82 (50%), Gaps = 2/82 (2%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G  + L+  +   P PK+ W + ++ +    +++SL Q    R T +IK  ++ D+G YT
Sbjct: 29062 GSDLVLDAAVGGKPEPKIIWTKGDKELDL-CEKVSL-QYTGKRATAVIKFCDRSDSGKYT 29119

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             ++  N +G    +  + V   P
Sbjct: 29120 LTVKNASGTKAVSVMVKVLDSP 29141



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 25/84 (29%), Positives = 42/84 (50%), Gaps = 3/84 (3%)

Query: 257   ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRAS 316
             + ++I  G   R+   VSG P P ++W   G  + S     +I + +    LI + V   
Sbjct: 29454 KTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLAS---RAIIDTTESYSLLIVDKVNRY 29510

Query: 317   DAGAYACVAKNRAGEATFTVQLDV 340
             DAG Y   A+N++G+ + TV + V
Sbjct: 29511 DAGKYTIEAENQSGKKSATVLVKV 29534



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 29/115 (25%), Positives = 42/115 (36%), Gaps = 12/115 (10%)

Query: 348   APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
             A   + KP+S  V EG+S +  C     P P + W R  +++  +T           + T
Sbjct: 32560 AARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVL--STSARHQVTTTKYKST 32617

Query: 408   LLIKDVNKKDAGWYTVSAVNEAGVTTCN----------TRLDVTARPNQTLPAPK 452
               I  V   D G Y+V   N  G               T   VT+ P    P P+
Sbjct: 32618 FEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPR 32672



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 24/69 (34%), Positives = 37/69 (53%), Gaps = 4/69 (5%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLL-IKDVNKKDAGWY 421
             G +++L   +   PPPK+ W + N  ++   DRI L   +T   T L  ++VNK DAG Y
Sbjct: 19708 GVTMRLYVPVKGRPPPKITWSKPNVNLR---DRIGLDIKSTDFDTFLRCENVNKYDAGKY 19764

Query: 422   TVSAVNEAG 430
              ++  N  G
Sbjct: 19765 ILTLENSCG 19773



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 27/92 (29%), Positives = 43/92 (46%), Gaps = 11/92 (11%)

Query: 341   LAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTD-RI 396
             +AKE +  P+F    + +K L    G S  +       P P + W + +      TD R 
Sbjct: 26176 IAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPD------TDLRT 26229

Query: 397   SLYQDNT-GRVTLLIKDVNKKDAGWYTVSAVN 427
               Y D T  R +L I++ N+ D+G YT++  N
Sbjct: 26230 RAYVDTTDSRTSLTIENANRNDSGKYTLTIQN 26261



 Score = 37.4 bits (85), Expect = 0.032
 Identities = 27/99 (27%), Positives = 41/99 (41%), Gaps = 3/99 (3%)

Query: 248   YPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQ-SDDLHKMIVSEKGLH 306
             + PR      +  +  G+  R    V   P  +V WY NG  +Q S  +H    +  G+ 
Sbjct: 32372 HAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIH--YTNTSGVL 32429

Query: 307   SLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEH 345
             +L        D+G Y  V  N  GEA+    LDV   ++
Sbjct: 32430 TLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDY 32468



 Score = 37.0 bits (84), Expect = 0.042
 Identities = 26/93 (27%), Positives = 45/93 (48%), Gaps = 4/93 (4%)

Query: 253   IQVPENM-SIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI-F 310
             +++P N  SI  G   +++  V G P P++SW  +G  ++     ++ V E    +++  
Sbjct: 24314 LKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTT--RVNVEETATSTVLHI 24371

Query: 311   EVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
             +     D G Y   A N AG AT  + + VL K
Sbjct: 24372 KEGNKDDFGKYTVTATNSAGTATENLSVIVLEK 24404



 Score = 37.0 bits (84), Expect = 0.042
 Identities = 28/120 (23%), Positives = 54/120 (45%), Gaps = 8/120 (6%)

Query: 227   VRSRSTSRGDVNDQDAIQEKFYPPRF---IQVPENMSIDEGRFCRMDFKVSGLPAPDVSW 283
             V   S S G +  +D ++    PPR    ++  + + +  G   +++  ++G P P +SW
Sbjct: 25768 VSEPSESTGPIIVKDDVE----PPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISW 25823

Query: 284   YLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
               +G  ++     ++I ++      + + +R  D G Y    KN AG  +  V   VL K
Sbjct: 25824 AKDGIEIEERARTEIISTDNHTLLTVKDCIR-RDTGQYVLTLKNVAGTRSVAVNCKVLDK 25882



 Score = 36.6 bits (83), Expect = 0.054
 Identities = 38/139 (27%), Positives = 63/139 (45%), Gaps = 15/139 (10%)

Query: 325   AKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAIPPPKLF 381
             A N AG     V  DV   E + AP F    + ++ L    G S+++   I   P P++ 
Sbjct: 20750 AINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVT 20809

Query: 382   WKRNNEMVQFNTDRISLYQDNTGRVTLL-IKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
             W ++N  ++   +R ++  +NT   TLL I + N+ D G + ++  N AG  +    + V
Sbjct: 20810 WTKDNINLK---NRANI--ENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRV 20864

Query: 441   TARPNQTLPAPKQLRVRPT 459
                P         L +RPT
Sbjct: 20865 LDTPGPV------LNLRPT 20877



 Score = 36.6 bits (83), Expect = 0.054
 Identities = 30/132 (22%), Positives = 55/132 (41%), Gaps = 5/132 (3%)

Query: 347   RAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV 406
             +AP F  + ++  V    +  L C+++  P P + W R  + +  +  +  + +   G  
Sbjct: 30926 QAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYH 30985

Query: 407   TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLAL 466
              L+I  V   DA  Y V A N+ G  +    L+V       LP     +         AL
Sbjct: 30986 QLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLP-----KTLEGMGAVHAL 31040

Query: 467   NGKGLNVKQAFN 478
              G+ +++K  F+
Sbjct: 31041 RGEVVSIKIPFS 31052



 Score = 35.8 bits (81), Expect = 0.093
 Identities = 30/120 (25%), Positives = 56/120 (46%), Gaps = 12/120 (10%)

Query: 231   STSRGDVNDQDAIQEKFYPPRFIQV--PENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGR 288
             S + G++   D IQE+  P  FI +   + +    G   R+   + G P P  SW  +G+
Sbjct: 15793 SDTTGEIPATD-IQEE--PEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSWEFDGK 15849

Query: 289   TVQS--DDLHKM-----IVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
               ++  D +H +     + + +    +I    + S  G Y+  AKN+AG+ T   ++ V+
Sbjct: 15850 AKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVM 15909



 Score = 35.8 bits (81), Expect = 0.093
 Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 5/95 (5%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
             P   +   + ++I  G    +  + SG P P VSW+ +   V  DD   +  +     +L
Sbjct: 16818 PTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPA---TL 16874

Query: 309   IFEVVRA--SDAGAYACVAKNRAGEATFTVQLDVL 341
               E ++A  SD+G Y  V +N  G      Q++V+
Sbjct: 16875 ALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVV 16909



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 24/100 (24%), Positives = 44/100 (44%), Gaps = 10/100 (10%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT------LLIKDVNKK 416
             G  +++   I   P PK  W+ + +  +   D +    ++    T      ++I +  + 
Sbjct: 15825 GSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRS 15884

Query: 417   DAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRV 456
               G Y+++A N+AG  T N R+ V   P      PK L+V
Sbjct: 15885 HTGKYSITAKNKAGQKTANCRVKVMDVPG----PPKDLKV 15920



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 42/166 (25%), Positives = 70/166 (42%), Gaps = 16/166 (9%)

Query: 298   MIVSEKGLHSLIFEVVRASDAGAY--ACVAKNRAGEATFT-VQLDVLAKEHKRAPMFIYK 354
             M     G++    EV +  +   Y     A N+AG      V   ++ +E   AP     
Sbjct: 22886 MCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLD 22945

Query: 355   PQSKKVLE---GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIK 411
              + +K++    G S++L   I   P P++ W + +  +     R +   D T   T L+ 
Sbjct: 22946 LELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEI-----RDAAIIDVTSSFTSLVL 23000

Query: 412   D-VNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRV 456
             D VN+ D+G YT++  N +G  +      VT R   T   P  L+V
Sbjct: 23001 DNVNRYDSGKYTLTLENSSGTKSA----FVTVRVLDTPSPPVNLKV 23042



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 25/110 (22%), Positives = 50/110 (45%), Gaps = 2/110 (1%)

Query: 340   VLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLY 399
             V+A++ +  P       +  V   + +K++      P   + W+++ + ++  T R+++ 
Sbjct: 25386 VIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLK-ETTRVNVS 25444

Query: 400   QDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLP 449
                T   +L IK+ +K+D G Y +   N AG  T    + V  RP    P
Sbjct: 25445 SSKTV-TSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGP 25493



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 25/94 (26%), Positives = 43/94 (45%), Gaps = 2/94 (2%)

Query: 348   APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
             AP    + +S +V  G + +    + + P  ++ W  N   +Q  + +I  Y + +G +T
Sbjct: 32373 APRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQ-ESSKIH-YTNTSGVLT 32430

Query: 408   LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVT 441
             L I D +  D+G Y     N  G  +    LDVT
Sbjct: 32431 LEILDCHTDDSGTYRAVCTNYKGEASDYATLDVT 32464



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 26/114 (22%), Positives = 50/114 (43%), Gaps = 8/114 (7%)

Query: 231   STSRGDVNDQDAIQEKFYPPRFIQVP---ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNG 287
             S S G +  +D ++     PR    P   + + ++ G   R++  V G P P + W    
Sbjct: 23608 SDSTGPITAKDEVEL----PRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGD 23663

Query: 288   RTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
             + ++     ++  ++     ++ + +R  D G Y   A N AG  +F V + VL
Sbjct: 23664 KEIEESARCEIKNTDFKALLIVKDAIRI-DGGQYILRASNVAGSKSFPVNVKVL 23716



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 22/104 (21%), Positives = 44/104 (42%), Gaps = 5/104 (4%)

Query: 240   QDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMI 299
             +D + E    P F     + S+  G+  +++  +SG P P ++W  +G  ++       +
Sbjct: 23224 KDLVIEPDVKPAF----SSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLK-QTTRINV 23278

Query: 300   VSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
                  L +L  +     D G Y     N  G+ T ++++  L K
Sbjct: 23279 TDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDK 23322



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 22/69 (31%), Positives = 34/69 (49%), Gaps = 3/69 (4%)

Query: 257  ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGL-HSLIFEVVRA 315
            +++++ EG    ++ KVS      V WYLN   ++ DD  + IV  KG    L+     A
Sbjct: 2452 KDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIV--KGTKQRLVINRTHA 2509

Query: 316  SDAGAYACV 324
            SD G Y  +
Sbjct: 2510 SDEGPYKLI 2518



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 27/126 (21%), Positives = 55/126 (43%), Gaps = 12/126 (9%)

Query: 253   IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEV 312
             ++  + + +  G   R++  VSG P P + W  +G+ ++     ++ +++    +L+ + 
Sbjct: 21465 VKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFST-NLVNKD 21523

Query: 313   VRASDAGAYACVAKNRAGEATFTVQLDVLAKE-HKRAPMFIYKPQSKKVLEGDSVKLECQ 371
                 D+GAY   A N  G A     + VL +      P+ + +  S+K          C 
Sbjct: 21524 STRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEK----------CV 21573

Query: 372   ISAIPP 377
             +S  PP
Sbjct: 21574 LSWFPP 21579



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 20/85 (23%), Positives = 37/85 (43%), Gaps = 2/85 (2%)

Query: 360   VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
             V  G+ +K+   I+  P P + W ++   ++       +  DN     L +KD  ++D G
Sbjct: 25801 VKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDN--HTLLTVKDCIRRDTG 25858

Query: 420   WYTVSAVNEAGVTTCNTRLDVTARP 444
              Y ++  N AG  +      V  +P
Sbjct: 25859 QYVLTLKNVAGTRSVAVNCKVLDKP 25883



 Score = 33.9 bits (76), Expect = 0.35
 Identities = 22/94 (23%), Positives = 37/94 (39%), Gaps = 4/94 (4%)

Query: 356   QSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNK 415
             Q+  V  G S++L       P P   W + +  +    D            TL +++ N+
Sbjct: 28365 QTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRAD----IHTTDSFSTLTVENCNR 28420

Query: 416   KDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLP 449
              DAG YT++  N +G  +    + V   P    P
Sbjct: 28421 NDAGKYTLTVENNSGSKSITFTVKVLDTPGPPGP 28454



 Score = 33.5 bits (75), Expect = 0.46
 Identities = 36/159 (22%), Positives = 62/159 (38%), Gaps = 16/159 (10%)

Query: 198   VFQAQDDSGAQDSQQHNSEHARLQVP------TSQVRSRSTSRGDVNDQDAIQEKFYPPR 251
             V +A  D+  + +   N +  R +V         Q R  + ++   +D   + +K YP  
Sbjct: 19627 VKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKD 19686

Query: 252   FIQVPEN---------MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSE 302
              +  PE          + +  G   R+   V G P P ++W      ++ D +   I S 
Sbjct: 19687 ILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLR-DRIGLDIKST 19745

Query: 303   KGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
                  L  E V   DAG Y    +N  G+  +T+ + VL
Sbjct: 19746 DFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVL 19784



 Score = 33.1 bits (74), Expect = 0.60
 Identities = 23/85 (27%), Positives = 38/85 (44%), Gaps = 2/85 (2%)

Query: 360   VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
             V  G +V+    I  +P P   W  +   ++ + +  ++  DN   V L IK+  ++D G
Sbjct: 17522 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTD-EHYTVETDNFSSV-LTIKNCLRRDTG 17579

Query: 420   WYTVSAVNEAGVTTCNTRLDVTARP 444
              Y ++  N AG  T    L V   P
Sbjct: 17580 EYQITVSNAAGSKTVAVHLTVLDVP 17604



 Score = 33.1 bits (74), Expect = 0.60
 Identities = 25/95 (26%), Positives = 39/95 (41%), Gaps = 1/95 (1%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
             PP F  +    ++  G   ++D    G P P V+W+ +   ++         +E      
Sbjct: 22147 PPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLT 22206

Query: 309   IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
             I +  R  D G Y     N AGEA  T+ + VL K
Sbjct: 22207 IKDACR-EDVGHYVVKLTNSAGEAIETLNVIVLDK 22240



 Score = 32.7 bits (73), Expect = 0.78
 Identities = 22/95 (23%), Positives = 38/95 (40%), Gaps = 7/95 (7%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
             P + I VP       GR   +   ++G P P  SW+  G  ++  +    + +   +  L
Sbjct: 29744 PQKTIHVPA------GRPVELVIPIAGRPPPAASWFFAGSKLRESE-RVTVETHTKVAKL 29796

Query: 309   IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
                     D G Y    KN  G  + T+++ +L K
Sbjct: 29797 TIRETTIRDTGEYTLELKNVTGTTSETIKVIILDK 29831



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 30/134 (22%), Positives = 44/134 (32%), Gaps = 9/134 (6%)

Query: 216   EHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPP----RFIQVPENMSIDEGRFCRMDF 271
             EH   +     V     S   +     IQ+   PP    R     + + +  G    +  
Sbjct: 15361 EHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPA 15420

Query: 272   KVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHS-----LIFEVVRASDAGAYACVAK 326
              V+GLP P + W  N   ++       I  E+   S     L        D G Y   A 
Sbjct: 15421 DVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTAS 15480

Query: 327   NRAGEATFTVQLDV 340
             NR G     V ++V
Sbjct: 15481 NRLGSVFRNVHVEV 15494



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 33/126 (26%), Positives = 58/126 (46%), Gaps = 8/126 (6%)

Query: 365   SVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIK-DVNKKDAGWYTV 423
             +++L   I   P P++ W R++     + D+ S+  ++T   TLLI  +VN+ D+G Y +
Sbjct: 21877 TLRLFVPIKGRPAPEVKWARDHGE---SLDKASI--ESTSSYTLLIVGNVNRFDSGKYIL 21931

Query: 424   SAVNEAGVTTC--NTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNPEG 481
             +  N +G  +   N R+  T  P Q L   +  +   T +    L   G  +K     + 
Sbjct: 21932 TVENSSGSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVEKR 21991

Query: 482   EFQRLA 487
             E  R A
Sbjct: 21992 ESTRKA 21997



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 23/87 (26%), Positives = 34/87 (39%), Gaps = 1/87 (1%)

Query: 273   VSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEA 332
             + G P P  SW   G+ ++  D+   I S      L  +     DAG Y   A N  G  
Sbjct: 20403 ILGKPLPKSSWSKAGKDIRPSDI-TQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTK 20461

Query: 333   TFTVQLDVLAKEHKRAPMFIYKPQSKK 359
                V++ VL       P+ I    ++K
Sbjct: 20462 VEHVKVTVLDVPGPPGPVEISNVSAEK 20488



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 26/109 (23%), Positives = 46/109 (42%), Gaps = 6/109 (5%)

Query: 236   DVNDQDAIQEKFYPPRF---IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQS 292
             DV     ++EK   P     +++ + ++I  G   R+   + G P P+V W   G+    
Sbjct: 22926 DVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKW---GKVDGE 22982

Query: 293   DDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
                  +I       SL+ + V   D+G Y    +N +G  +  V + VL
Sbjct: 22983 IRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVL 23031



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 20/82 (24%), Positives = 40/82 (48%), Gaps = 2/82 (2%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G  V+L   I+  PPP   W      ++  ++R+++ + +T    L I++   +D G YT
Sbjct: 29753 GRPVELVIPIAGRPPPAASWFFAGSKLR-ESERVTV-ETHTKVAKLTIRETTIRDTGEYT 29810

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             +   N  G T+   ++ +  +P
Sbjct: 29811 LELKNVTGTTSETIKVIILDKP 29832



 Score = 30.8 bits (68), Expect = 3.0
 Identities = 23/87 (26%), Positives = 37/87 (42%), Gaps = 14/87 (16%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT-----LLIKDVNKKD 417
             G  +++   +S  PPP + W  N           +L Q+ T   T     ++IK+  +  
Sbjct: 16539 GGVIRIIAYVSGKPPPTVTWNMNER---------TLPQEATIETTAISSSMVIKNCQRSH 16589

Query: 418   AGWYTVSAVNEAGVTTCNTRLDVTARP 444
              G Y++ A NEAG       +DV   P
Sbjct: 16590 QGVYSLLAKNEAGERKKTIIVDVLDVP 16616



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 24/105 (22%), Positives = 43/105 (40%), Gaps = 13/105 (12%)

Query: 274   SGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEAT 333
             +G P P  +W    + +++ D  KM  +      L+      SD G Y    +NR    +
Sbjct: 13419 TGYPRPTATWCFGDKVLETGDRVKM-KTLSAYAELVISPSERSDKGIYTLKLENRVKTIS 13477

Query: 334   FTVQLDVLAKEHKRAPMFIYKPQSKKVLE-GDSVKLECQISAIPP 377
               + ++V+A           +P + K L+ GD  K    ++  PP
Sbjct: 13478 GEIDVNVIA-----------RPSAPKELKFGDITKDSVHLTWEPP 13511



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 25/113 (22%), Positives = 45/113 (39%), Gaps = 5/113 (4%)

Query: 231   STSRGDVNDQDAIQ--EKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGR 288
             S S G +  +D I        P++  V   + +  G    ++  + G P PDV W  +G+
Sbjct: 24690 SDSSGAITARDEIDAPNASLDPKYKDV---IVVHAGETFVLEADIRGKPIPDVVWSKDGK 24746

Query: 289   TVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
              ++       I S     +L+ +    +D G Y     N  G  +  + + VL
Sbjct: 24747 ELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVL 24799



 Score = 30.0 bits (66), Expect = 5.1
 Identities = 25/96 (26%), Positives = 48/96 (50%), Gaps = 7/96 (7%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLL-IKDVNKKDAGWY 421
             G+ V++       PPP + W+++ + +  +  R S+  +NT   +LL I  V + D G Y
Sbjct: 27286 GEDVQVLIPFKGRPPPTVTWRKDEKNLGSDA-RYSI--ENTDSSSLLTIPQVTRNDTGKY 27342

Query: 422   TVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVR 457
              ++  N  G    +T   V+ +   T  A ++L+V+
Sbjct: 27343 ILTIENGVGEPKSST---VSVKVLDTPAACQKLQVK 27375



 Score = 30.0 bits (66), Expect = 5.1
 Identities = 16/61 (26%), Positives = 26/61 (42%), Gaps = 2/61 (3%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G +V LE      P P + W ++   +         +     ++TL IK+  K+  G YT
Sbjct: 27578 GHNVHLELPYKGKPKPSISWLKDG--LPLKESEFVRFSKTENKITLSIKNAKKEHGGKYT 27635

Query: 423   V 423
             V
Sbjct: 27636 V 27636



 Score = 29.6 bits (65), Expect = 6.6
 Identities = 24/102 (23%), Positives = 42/102 (41%), Gaps = 8/102 (7%)

Query: 244   QEKFYPPRFIQVPENMSIDEGRFC---RMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIV 300
             +++  PP      +   +   R C   R+   + G PAP+V W  +      + L K  +
Sbjct: 21852 EDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARD----HGESLDKASI 21907

Query: 301   SEKGLHS-LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
                  ++ LI   V   D+G Y    +N +G  +  V + VL
Sbjct: 21908 ESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVL 21949



 Score = 29.6 bits (65), Expect = 6.6
 Identities = 21/84 (25%), Positives = 36/84 (42%), Gaps = 3/84 (3%)

Query: 259   MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL-IFEVVRASD 317
             ++I  G    +D  V G P P + W    + +  D   K+ +   G  +  + +    SD
Sbjct: 29057 VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKEL--DLCEKVSLQYTGKRATAVIKFCDRSD 29114

Query: 318   AGAYACVAKNRAGEATFTVQLDVL 341
             +G Y    KN +G    +V + VL
Sbjct: 29115 SGKYTLTVKNASGTKAVSVMVKVL 29138



 Score = 29.3 bits (64), Expect = 8.7
 Identities = 18/86 (20%), Positives = 37/86 (43%), Gaps = 4/86 (4%)

Query: 360   VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
             V +G  ++L   I   P P   W +  + +     + ++   +     L+IK+ ++ D+G
Sbjct: 30148 VRQGGVIRLTIPIKGKPFPICKWTKEGQDIS----KRAMIATSETHTELVIKEADRGDSG 30203

Query: 420   WYTVSAVNEAGVTTCNTRLDVTARPN 445
              Y +   N+ G      ++ V   PN
Sbjct: 30204 TYDLVLENKCGKKAVYIKVRVIGSPN 30229


>gi|110349717 titin isoform novex-2 [Homo sapiens]
          Length = 27118

 Score =  127 bits (320), Expect = 2e-29
 Identities = 66/216 (30%), Positives = 115/216 (53%)

Query: 245  EKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG 304
            E+ Y P F+  P +    EG+  R D KV G P P+  W+ +G+ + +D  HK+++ E G
Sbjct: 1406 ERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDG 1465

Query: 305  LHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGD 364
              SLI      SD+G +  VA+NRAG ++ +V L V A EH+  PMF+ K ++  + EG 
Sbjct: 1466 TQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGS 1525

Query: 365  SVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVS 424
             ++++ + +  P P + W +N++++  +       +   G   L I     +D+ WYT +
Sbjct: 1526 RLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTAT 1585

Query: 425  AVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTF 460
            A+N+AG  T   +++V     +  P  K +  R T+
Sbjct: 1586 AINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTY 1621



 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 62/198 (31%), Positives = 92/198 (46%), Gaps = 7/198 (3%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIV--SEKGLH 306
             PP F     N +   G   R    ++  P P V+WY +G+ ++  D  K     S+KGL+
Sbjct: 25384 PPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLY 25443

Query: 307   SLIFEVVRASDAGAYACVAKNRAGE----ATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE 362
              L    V   D   Y  VA+N+ GE    A  TV L     +    PMF     + +  E
Sbjct: 25444 QLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQE 25503

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G SV  E ++S IPPP L W+++ + +    + I +  +      L I+D   +D G+Y 
Sbjct: 25504 GQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPN-IEIIHEGLDYYALHIRDTLPEDTGYYR 25562

Query: 423   VSAVNEAGVTTCNTRLDV 440
             V+A N AG T+C   L V
Sbjct: 25563 VTATNTAGSTSCQAHLQV 25580



 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 62/213 (29%), Positives = 109/213 (51%), Gaps = 13/213 (6%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVS-EKGLHSL 308
           P F Q  +++ + EG     +  +SG P P+VSW+ +G+ + +  L  + +S   G   L
Sbjct: 6   PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65

Query: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
               V  +++G Y+  A N +G+AT T +L  L K     P F+ + QS  V +G  V+L
Sbjct: 66  TIPAVTKANSGRYSLKATNGSGQATSTAEL--LVKAETAPPNFVQRLQSMTVRQGSQVRL 123

Query: 369 ECQISAIPPPKLFWKRNNEMVQFNTD-RISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
           + +++ IP P + + R+   +Q + D +IS   D     +LLI +   +D+G Y+V+A N
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGD---LYSLLIAEAYPEDSGTYSVNATN 180

Query: 428 EAGVTTCNTRL------DVTARPNQTLPAPKQL 454
             G  T    L      +V A+  +T+ +  Q+
Sbjct: 181 SVGRATSTAELLVQGEEEVPAKKTKTIVSTAQI 213



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 60/231 (25%), Positives = 94/231 (40%), Gaps = 42/231 (18%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP  +   +N+++ EG    ++  +SG P+P V+WY     ++S  +   I  + G+  L
Sbjct: 896  PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESS-IDFQITFQSGIARL 954

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDV----------------LAKEHKR----- 347
            +     A D+G + C A N AG  + +  L V                   E KR     
Sbjct: 955  MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESR 1014

Query: 348  --------------------APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNE 387
                                AP FI KP  +K++EG SV   CQ+   P P ++WK++  
Sbjct: 1015 DVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGV 1074

Query: 388  MVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 438
             +         Y   TG   L+I      DAG YT+   N+ G T+ +  L
Sbjct: 1075 PLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 55/182 (30%), Positives = 94/182 (51%), Gaps = 6/182 (3%)

Query: 259   MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDA 318
             MSI+EG+  R+  K +   A DV W LNG  + + + ++  VS     +L  +     D 
Sbjct: 26743 MSINEGQ--RLVLKANIAGATDVKWVLNGVELTNSEEYRYGVSGSD-QTLTIKQASHRDE 26799

Query: 319   GAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPP 378
             G   C++K + G       L  L+KE   AP FI +P+S+ + EG +V   C+IS  P P
Sbjct: 26800 GILTCISKTKEGIVKCQYDL-TLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSP 26858

Query: 379   KLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 438
             ++ W +NN  +  +++ +S+ + +    +L I++ +  D+G YT+ A N  G  +    L
Sbjct: 26859 EIEWFKNNLPISISSN-VSISR-SRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASL 26916

Query: 439   DV 440
              V
Sbjct: 26917 MV 26918



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 53/197 (26%), Positives = 83/197 (42%), Gaps = 2/197 (1%)

Query: 250   PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG-LHSL 308
             P F +   N+++       +  KV+G P P V WY  G+ + +D L   I   KG  H L
Sbjct: 24623 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQL 24682

Query: 309   IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
             I   V   DA  Y   A N+ G  + T  L+V        P  +    +   L G+ V +
Sbjct: 24683 IIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSI 24742

Query: 369   ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
             +   S  P P + W++  +++  N     +    +    +    V +KDAG+Y V A N 
Sbjct: 24743 KIPFSGKPDPVITWQKGQDLID-NNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNR 24801

Query: 429   AGVTTCNTRLDVTARPN 445
              G+      LDV   P+
Sbjct: 24802 FGIDQKTVELDVADVPD 24818



 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 53/229 (23%), Positives = 88/229 (38%), Gaps = 22/229 (9%)

Query: 250  PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
            P FI+   N  I  G    +   V G+P P + W+ NG  +     +K +      HSLI
Sbjct: 3649 PIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDD-HSLI 3707

Query: 310  FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK--EHKRA------------------P 349
                +  D G Y C+A N  G+   +  L + +K   HK                    P
Sbjct: 3708 ILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKLGGPCPP 3767

Query: 350  MFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLL 409
             F+ + +  +  +G     E  +   P P + W + N+ +  +     ++  N G  T +
Sbjct: 3768 HFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPN-GSGTFI 3826

Query: 410  IKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRP 458
            + D  ++D+G Y   A N  G +TC   L V          P + +  P
Sbjct: 3827 VNDPQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDTPCKAKSTP 3875



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 60/254 (23%), Positives = 116/254 (45%), Gaps = 21/254 (8%)

Query: 191  GPQNAAAVFQAQDDS--GAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFY 248
            G  +A    + QD+S   +++ ++ +SE    +V T +++    + G +  +D       
Sbjct: 4384 GVASAVVSDEKQDESLKPSEEKEESSSESGTEEVATVKIQE---AEGGLIKEDG------ 4434

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P     + + +S +EG    +   ++   A +V+WY   + V SD+  K +  ++  ++L
Sbjct: 4435 PMIHTPLVDTVS-EEGDIVHLTTSITN--AKEVNWYFENKLVPSDEKFKCL-QDQNTYTL 4490

Query: 309  IFEVVRASD-AGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
            + + V   D  G Y C A N +G+   + +L V+    + AP+   K +  +V  G   K
Sbjct: 4491 VIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVV---KRAAPVIKRKIEPLEVALGHLAK 4547

Query: 368  LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
              C+I + P  +  W +    + + +D+ S+ + +    +L I      D G YT  A N
Sbjct: 4548 FTCEIQSAPNVRFQWFKAGREI-YESDKCSI-RSSKYISSLEILRTQVVDCGEYTCKASN 4605

Query: 428  EAGVTTCNTRLDVT 441
            E G  +C   L VT
Sbjct: 4606 EYGSVSCTATLTVT 4619



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 39/126 (30%), Positives = 64/126 (50%), Gaps = 1/126 (0%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
           PP F+Q  ++M++ +G   R+  +V+G+P P V +Y +G  +QS  L   I  E  L+SL
Sbjct: 103 PPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQS-SLDFQISQEGDLYSL 161

Query: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
           +       D+G Y+  A N  G AT T +L V  +E   A        + ++ E    ++
Sbjct: 162 LIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRI 221

Query: 369 ECQISA 374
           E +I A
Sbjct: 222 EKKIEA 227



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 53/209 (25%), Positives = 89/209 (42%), Gaps = 14/209 (6%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP+ +Q  + +++  G+  R    +SG P P +SWY   + + +    K +   +    L
Sbjct: 3192 PPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLL 3251

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKE--HKRAPMFIYKP------QSKKV 360
            + E     DA  Y C AKN  G AT +  L V   E       M +Y P      Q    
Sbjct: 3252 LIEAF-PEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVT 3310

Query: 361  LEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGW 420
             EG   + +C++S       ++ ++ ++      R++ ++D      L I +   +D G 
Sbjct: 3311 SEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDT---YQLEIAEAYPEDEGT 3367

Query: 421  YTVSAVNEAG--VTTCNTRLDVTARPNQT 447
            YT  A N  G   +T N  L+V A   Q+
Sbjct: 3368 YTFVASNAVGQVSSTANLSLEVQALDRQS 3396



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 52/176 (29%), Positives = 78/176 (44%), Gaps = 16/176 (9%)

Query: 280  DVSWYLNGRTV--QSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQ 337
            D  WY +G  +  Q  + HK +V E+ +H +     R SDAG Y  V    AG    +V 
Sbjct: 3130 DAHWYKDGIEINFQVQERHKYVV-ERRIHRMFISETRQSDAGEYTFV----AGRNRSSVT 3184

Query: 338  LDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRIS 397
            L V A E    P  + + Q   V  G   +    IS  P PK+ W +  +++  +T    
Sbjct: 3185 LYVNAPE---PPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLL--STGFKC 3239

Query: 398  LYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV----TARPNQTLP 449
             +  +    TLL+ +   +DA  YT  A N+ GV T +  L V       P+Q +P
Sbjct: 3240 KFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMP 3295



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 50/209 (23%), Positives = 84/209 (40%), Gaps = 30/209 (14%)

Query: 281   VSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
             V+WY   R +++ + ++ I  E G+  L  + +   D G Y C   N  GE +   +L V
Sbjct: 25295 VTWYFGVRQLENSEKYE-ITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFV 25353

Query: 341   LAKEH-----------------------KRAPMFIYKPQSKKVLEGDSVKLECQISAIPP 377
                                         +R P F     +K    G++V+    I+  P 
Sbjct: 25354 KGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPE 25413

Query: 378   PKLFWKRNNEMVQ-FNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
             P + W ++ + ++  + D+   ++ + G   L I  V   D   YTV A N+ G  +C  
Sbjct: 25414 PHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKA 25473

Query: 437   RLDVTARPNQTLPAPKQLRVRPTFSKYLA 465
             +L VT       P P    +RP F + LA
Sbjct: 25474 KLTVTLH-----PPPTDSTLRPMFKRLLA 25497



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 47/185 (25%), Positives = 87/185 (47%), Gaps = 8/185 (4%)

Query: 264   GRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYAC 323
             G   ++  ++ G P PD+ WY  G+ +     +KM  S+   H+L        D G Y C
Sbjct: 24242 GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKM-SSDGRTHTLTVMTEEQEDEGVYTC 24300

Query: 324   VAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWK 383
             +A N  GE   + +L +L    +  P +  K +    + G +++L       P P + W 
Sbjct: 24301 IATNEVGEVETSSKL-LLQATPQFHPGYPLKEKYYGAV-GSTLRLHVMYIGRPVPAMTWF 24358

Query: 384   RNNEMVQFNTDRISLYQDNTGRVT-LLIKDVNKK-DAGWYTVSAVNEAGVTTCNTRLDVT 441
                +++Q N++ I++  +NT   T L++K+V +K  AG Y V   N  G       +++ 
Sbjct: 24359 HGQKLLQ-NSENITI--ENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQ 24415

Query: 442   ARPNQ 446
              +P++
Sbjct: 24416 DKPDK 24420



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 36/117 (30%), Positives = 59/117 (50%), Gaps = 2/117 (1%)

Query: 324 VAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWK 383
           V   R  + T T ++    +     P  +   ++  V+EG+SV LEC IS  P P + W 
Sbjct: 872 VLHGREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWY 931

Query: 384 RNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
           R +  ++ + D    +Q    R  L+I++   +D+G +T SAVNEAG  + +  L V
Sbjct: 932 REDYQIESSIDFQITFQSGIAR--LMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV 986



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 62/264 (23%), Positives = 108/264 (40%), Gaps = 44/264 (16%)

Query: 235  GDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD 294
            GD+ D++  Q+ F+  +   +           CR+     G P   V W  +G+ +++ +
Sbjct: 1646 GDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLT--PIGDPTMVVEWLHDGKPLEAAN 1703

Query: 295  LHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAG----EATFTV-------------- 336
              +MI +E G  SL + V  + D+G   C A N+ G     AT  V              
Sbjct: 1704 RLRMI-NEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPE 1762

Query: 337  ---------QLDVLAKE-----------HKRAPMFIYKPQSKKVLEGDSVKLECQISAIP 376
                     +L+ +A E            K+ P  +  P+  +VLEG++ +  C+++  P
Sbjct: 1763 GRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYP 1822

Query: 377  PPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
             PK+ W  N ++++  + R  +  D  G   L I D    D G   V+A N  GV     
Sbjct: 1823 QPKVNWYLNGQLIR-KSKRFRVRYD--GIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKV 1879

Query: 437  RLDVTARPNQTLPAPKQLRVRPTF 460
            +L++  R +      +    RP F
Sbjct: 1880 KLEIQQREDFRSVLRRAPEPRPEF 1903



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 46/166 (27%), Positives = 79/166 (47%), Gaps = 13/166 (7%)

Query: 258  NMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASD 317
            N+ + E    ++  +VS  P  +V WY     +     ++ I++E     L+ +     D
Sbjct: 6166 NIEVSETDTIKLVCEVSK-PGAEVIWYKGDEEIIETGRYE-ILTEGRKRILVIQNAHLED 6223

Query: 318  AGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPP 377
            AG Y C   +         + D   K H+ A  FI KPQ+ ++LEG+  +  C IS    
Sbjct: 6224 AGNYNCRLPSS--------RTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESF 6275

Query: 378  PKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTV 423
            P + WKR+++ ++ + D+  +  D   RV L++KD   +D G Y V
Sbjct: 6276 P-VQWKRDDKTLE-SGDKYDVIADGKKRV-LVVKDATLQDMGTYVV 6318



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 1/125 (0%)

Query: 250   PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
             P FI  P + +I+EG+      ++SG P+P++ W+ N   + S   +  I   + ++SL 
Sbjct: 26829 PAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPI-SISSNVSISRSRNVYSLE 26887

Query: 310   FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLE 369
                   SD+G Y   AKN  G+ + T  L VL    + +   + +      L+G      
Sbjct: 26888 IRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQS 26947

Query: 370   CQISA 374
              Q+SA
Sbjct: 26948 VQMSA 26952



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 35/102 (34%), Positives = 50/102 (49%), Gaps = 3/102 (2%)

Query: 347 RAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV 406
           +AP F    QS  VLEG +   E  IS  P P++ W R+ +++  +T        + GR 
Sbjct: 4   QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63

Query: 407 TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV---TARPN 445
            L I  V K ++G Y++ A N +G  T    L V   TA PN
Sbjct: 64  KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPN 105



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 33/129 (25%), Positives = 63/129 (48%), Gaps = 8/129 (6%)

Query: 325  AKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSK----KVLEGDSVKLECQISAIPPPKL 380
            A N  GE+  ++ L+V+ ++ +  P    +   +    KV  G+ V +   ++ +P PK+
Sbjct: 9066 AVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKI 9125

Query: 381  FWKRNNEMVQFNTDRISLYQDNTGR----VTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
             W +N  +++  TD + + ++   R      L I    ++D G YTV+A N  G    N 
Sbjct: 9126 EWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNV 9185

Query: 437  RLDVTARPN 445
             ++V  RP+
Sbjct: 9186 HVEVYDRPS 9194



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 38/158 (24%), Positives = 66/158 (41%), Gaps = 4/158 (2%)

Query: 191  GPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPP 250
            G  + +A    +D+    +  Q       LQ    +   R    G +      Q++   P
Sbjct: 1738 GTDHTSATLIVKDEKSLVEESQLPEGRKGLQ--RIEELERMAHEGALTGVTTDQKEKQKP 1795

Query: 251  RFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
              +  PE + + EG   R   +V+G P P V+WYLNG+ ++     +  V   G+H L  
Sbjct: 1796 DIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKS--KRFRVRYDGIHYLDI 1853

Query: 311  EVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRA 348
               ++ D G     A+N  G     V+L++  +E  R+
Sbjct: 1854 VDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRS 1891



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 43/153 (28%), Positives = 68/153 (44%), Gaps = 11/153 (7%)

Query: 301  SEKGLHSLIFEVVRASDAGAYACVAK--NRAGEATFTVQLDVLAKEHKRAPMFIYKPQSK 358
            +++ +  L F V    + G Y    K  N AG +  +  +     +    P  I   +  
Sbjct: 9762 NKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFM 9821

Query: 359  KVLEGDSVKLECQISAIPPPKLFWKR-------NNEMVQFNTDRISLYQDNTGRVTLLIK 411
            +V EG +V +  +I  +P P L W +       N E V ++T    L  D+T   TL+I 
Sbjct: 9822 EVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDT--CTLVIP 9879

Query: 412  DVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARP 444
               + D G YT++AVN  G  +   RL+V  RP
Sbjct: 9880 QSRRSDTGLYTITAVNNLGTASKEMRLNVLGRP 9912



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 48/162 (29%), Positives = 72/162 (44%), Gaps = 11/162 (6%)

Query: 277  PAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTV 336
            P   V WY +G  V   D ++M  S++ +H L    +  SDA  Y+CV        T T 
Sbjct: 2155 PFVKVKWYKDGMEVHEGDKYRMH-SDRKVHFLSILTIDTSDAEDYSCVLVEDENVKT-TA 2212

Query: 337  QLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRI 396
            +L V          F+ + Q  +V E  S +LEC +S   P  +  K  +  V+  ++  
Sbjct: 2213 KLIV----EGAVVEFVKELQDIEVPESYSGELECIVS---PENIEGKWYHNDVELKSNGK 2265

Query: 397  SLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 438
                   GR  L +KDV K+D G Y  S V +   TTC  ++
Sbjct: 2266 YTITSRRGRQNLTVKDVTKEDQGEY--SFVIDGKKTTCKLKM 2305



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 40/147 (27%), Positives = 71/147 (48%), Gaps = 3/147 (2%)

Query: 299   IVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQ-LDVLAKEHKRAPMFIYKPQS 357
             IV+E  + + +   + +     +   A N  G++   V  + V+AK+    P       +
Sbjct: 17956 IVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNT 18015

Query: 358   KKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKD 417
               +  G+ +K+E  +   P P + W ++ E ++  T R+++ +  T  V L IK+ NK D
Sbjct: 18016 YSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLK-QTTRVNVEETATSTV-LHIKEGNKDD 18073

Query: 418   AGWYTVSAVNEAGVTTCNTRLDVTARP 444
              G YTV+A N AG  T N  + V  +P
Sbjct: 18074 FGKYTVTATNSAGTATENLSVIVLEKP 18100



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 32/143 (22%), Positives = 67/143 (46%), Gaps = 2/143 (1%)

Query: 307   SLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSV 366
             SL+   ++      +   A+N  G +       V   + +  P  I  P+   +  G  +
Sbjct: 12552 SLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKL 12611

Query: 367   KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAV 426
             ++E  +   P P   WK+  + V   +  +++++ ++  + L+IKDV +KD+G+Y+++A 
Sbjct: 12612 RIEAHVYGKPHPTCKWKKGEDEV-VTSSHLAVHKADSSSI-LIIKDVTRKDSGYYSLTAE 12669

Query: 427   NEAGVTTCNTRLDVTARPNQTLP 449
             N +G  T   ++ V   P    P
Sbjct: 12670 NSSGTDTQKIKVVVMDAPGPPQP 12692



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 33/153 (21%), Positives = 65/153 (42%), Gaps = 6/153 (3%)

Query: 198  VFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFY------PPR 251
            +F   +D G       N     +     ++ S+     D   + A+ +         PP 
Sbjct: 3709 LFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKLGGPCPPH 3768

Query: 252  FIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFE 311
            F++  + +   +G     ++ V G PAP V+W+   + + +   + +I +  G  + I  
Sbjct: 3769 FLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNGSGTFIVN 3828

Query: 312  VVRASDAGAYACVAKNRAGEATFTVQLDVLAKE 344
              +  D+G Y C A+N  GE+T   +L VL ++
Sbjct: 3829 DPQREDSGLYICKAENMLGESTCAAELLVLLED 3861



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 28/93 (30%), Positives = 46/93 (49%), Gaps = 1/93 (1%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKM-IVSEKGLHS 307
             PP+   +P ++SIDEG+   +    +G P P+V+W   GR + S +  +  I +   L +
Sbjct: 27023 PPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTT 27082

Query: 308   LIFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
             LI   V+  D G Y     N  G  + TV + +
Sbjct: 27083 LIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 27115



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 34/117 (29%), Positives = 55/117 (47%), Gaps = 5/117 (4%)

Query: 236  DVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDL 295
            D+++ +A++  F   R     +N  I EG       K+SG P P ++WY +G+ ++  + 
Sbjct: 1236 DISESEAVESGF-DSRI----KNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGER 1290

Query: 296  HKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFI 352
            ++M   + G  SL   VV   D G Y   A N  G A  + +L V       AP +I
Sbjct: 1291 YQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYI 1347



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 48/189 (25%), Positives = 83/189 (43%), Gaps = 14/189 (7%)

Query: 244  QEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVS---WYLNGRTVQSDDLHKMIV 300
            Q K  P +F++  +++ + E  F         L +P  +   W  +G  ++    H+ I 
Sbjct: 4804 QLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSPSTAITTWMKDGSNIRESPKHRFIA 4863

Query: 301  SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKK- 359
              K     I +V + SDAG Y CV +    E T T +L V     +  P+   K   ++ 
Sbjct: 4864 DGKDRKLHIIDV-QLSDAGEYTCVLRLGNKEKTSTAKLVV-----EELPVRFVKTLEEEV 4917

Query: 360  -VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
             V++G  + L C+++      + W+++ ++V     RI        R  L I D +  DA
Sbjct: 4918 TVVKGQPLYLSCELN--KERDVVWRKDGKIVVEKPGRIVPGVIGLMR-ALTINDADDTDA 4974

Query: 419  GWYTVSAVN 427
            G YTV+  N
Sbjct: 4975 GTYTVTVEN 4983



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 48/179 (26%), Positives = 73/179 (40%), Gaps = 14/179 (7%)

Query: 252  FIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFE 311
            FI  P+N+ I EG        +S    P V W  + +T++S D + +I   K    L+ +
Sbjct: 6249 FISKPQNLEILEGEKAEFVCSISKESFP-VQWKRDDKTLESGDKYDVIADGKK-RVLVVK 6306

Query: 312  VVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQ 371
                 D G Y  +     G A     L V+ K     P+     +  +V E   V   C+
Sbjct: 6307 DATLQDMGTYVVMV----GAARAAAHLTVIEKLRIVVPL-----KDTRVKEQQEVVFNCE 6357

Query: 372  ISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
            ++     K  W RN E +  ++  I L +D     TL I+D +  D   Y VS  N  G
Sbjct: 6358 VNT-EGAKAKWFRNEEAIFDSSKYIILQKDLV--YTLRIRDAHLDDQANYNVSLTNHRG 6413



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 34/133 (25%), Positives = 64/133 (48%), Gaps = 10/133 (7%)

Query: 251   RFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
             R +  P +M++ EG   R      G P P V+W   G+ + +   H++  ++   +   F
Sbjct: 26257 RILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTK---YKSTF 26313

Query: 311   EV--VRASDAGAYACVAKNRAG----EATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGD 364
             E+  V+ASD G Y+ V +N  G    E T T+Q   + ++   +P  +  P+  +V   +
Sbjct: 26314 EISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPE-PRVKSPE 26372

Query: 365   SVKLECQISAIPP 377
             +VK   ++ +  P
Sbjct: 26373 AVKSPKRVKSPEP 26385



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 45/200 (22%), Positives = 85/200 (42%), Gaps = 17/200 (8%)

Query: 256   PENMSI-DEGR------FCRMDFKVSGLPAPDVSWYLNGRTVQSDD---LHKMIVSEKGL 305
             PEN+ I D+G+      + R D+      +P++S+++  R   SDD   +HK  + E   
Sbjct: 11799 PENLHIADKGKTFVYLKWRRPDYDGG---SPNLSYHVERRLKGSDDWERVHKGSIKET-- 11853

Query: 306   HSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE-GD 364
             H ++   V  +    +    KN  GE+ +    +V+ KE  + P+   K      ++ GD
Sbjct: 11854 HYMVDRCVE-NQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGD 11912

Query: 365   SVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVS 424
             +++LE  +   P P++ W ++ +                      +    + D G Y V+
Sbjct: 11913 TIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVT 11972

Query: 425   AVNEAGVTTCNTRLDVTARP 444
             A N AG       ++V  +P
Sbjct: 11973 ATNTAGSFVAYATVNVLDKP 11992



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 50/182 (27%), Positives = 83/182 (45%), Gaps = 21/182 (11%)

Query: 257  ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG-LHSLIFEVVRA 315
            +++++  G     D ++S    P V WYL G+ ++  D  K++   +G +H+L    V+ 
Sbjct: 5898 KDVTVTAGETATFDCELSYEDIP-VEWYLKGKKLEPSD--KVVPRSEGKVHTLTLRDVKL 5954

Query: 316  SDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKP-QSKKVLEGDSVKLECQISA 374
             DAG     AK+    A   V         K  P+   KP + + V EG +  LEC++S 
Sbjct: 5955 EDAGEVQLTAKDFKTHANLFV---------KEPPVEFTKPLEDQTVEEGATAVLECEVSR 6005

Query: 375  IPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV-TLLIKDVNKKDAGWYTVSAVNEAGVTT 433
                K+ W +N   +   + +  +  D  GRV  L+I D   +D   YT  A +    T+
Sbjct: 6006 -ENAKVKWFKNGTEI-LKSKKYEIVAD--GRVRKLVIHDCTPEDIKTYTCDAKDFK--TS 6059

Query: 434  CN 435
            CN
Sbjct: 6060 CN 6061



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 33/111 (29%), Positives = 55/111 (49%), Gaps = 8/111 (7%)

Query: 235   GDVNDQDAIQEKFYPPRF---IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTV- 290
             G+V D   ++++   P       V + + +  G   R+   VSG P P V+W +N RT+ 
Sbjct: 10202 GEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLP 10261

Query: 291   QSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
             Q   +    +S     S++ +  + S  G Y+ +AKN AGE   T+ +DVL
Sbjct: 10262 QEATIETTAISS----SMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVL 10308



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 62/269 (23%), Positives = 101/269 (37%), Gaps = 46/269 (17%)

Query: 166  KCKDTLLHNGNQRLTYEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTS 225
            K KD LLH   + LT EEK A                            +E  ++ +PT 
Sbjct: 1987 KTKDELLH-WTKELTEEEKKAL---------------------------AEEGKITIPTF 2018

Query: 226  QVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYL 285
            +            D+  +      P+  +  ++ ++ +G       +V G P P+  WY 
Sbjct: 2019 KP-----------DKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYK 2067

Query: 286  NGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEH 345
            NG  ++  D       E  +  L+   V A D+ +    A N AGE +    L V AK+ 
Sbjct: 2068 NGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQ- 2126

Query: 346  KRAPMFIYKPQSKKVLEGDSV-KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTG 404
                 F  + Q     E D++   EC+ S  P  K+ W ++  M     D+  ++ D   
Sbjct: 2127 --LITFTQELQDVVAKEKDTMATFECETSE-PFVKVKWYKDG-MEVHEGDKYRMHSDRKV 2182

Query: 405  RVTLLIKDVNKKDAGWYTVSAVNEAGVTT 433
               L I  ++  DA  Y+   V +  V T
Sbjct: 2183 HF-LSILTIDTSDAEDYSCVLVEDENVKT 2210



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 32/114 (28%), Positives = 56/114 (49%), Gaps = 3/114 (2%)

Query: 359  KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
            ++LEG  V   C++S  P PK+ W ++ + ++ + +R  +     GR +L I  V  +D 
Sbjct: 1255 RILEGMGVTFHCKMSGYPLPKIAWYKDGKRIK-HGERYQMDFLQDGRASLRIPVVLPEDE 1313

Query: 419  GWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLN 472
            G YT  A N  G   C+ +L V   P   L AP  +      S+  +L+ + ++
Sbjct: 1314 GIYTAFASNIKGNAICSGKLYV--EPAAPLGAPTYIPTLEPVSRIRSLSPRSVS 1365



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 30/82 (36%), Positives = 42/82 (51%), Gaps = 2/82 (2%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G    ++  IS  P PK+ WK   EM    TDR+S+      R TL +KD  + D+G Y 
Sbjct: 22357 GSPFTIDVPISGRPAPKVTWKLE-EMRLKETDRVSI-TTTKDRTTLTVKDSMRGDSGRYF 22414

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             ++  N AGV T +  + V  RP
Sbjct: 22415 LTLENTAGVKTFSVTVVVIGRP 22436



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 42/141 (29%), Positives = 74/141 (52%), Gaps = 14/141 (9%)

Query: 283  WYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLA 342
            WY N   ++S+  +  I S +G  +L  + V   D G Y+ V   +  + T  +++    
Sbjct: 2253 WYHNDVELKSNGKYT-ITSRRGRQNLTVKDVTKEDQGEYSFVIDGK--KTTCKLKM---- 2305

Query: 343  KEHKRAPMFIYKPQS-KKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQD 401
               K  P+ I +  S +KV EGD V+LE ++S +   +  W ++ + VQ  +DR+ +  D
Sbjct: 2306 ---KPRPIAILQGLSDQKVCEGDIVQLEVKVS-LESVEGVWMKDGQEVQ-PSDRVHIVID 2360

Query: 402  NTGRVTLLIKDVNKKDAGWYT 422
                + LLI+D+ K+DAG Y+
Sbjct: 2361 KQSHM-LLIEDMTKEDAGNYS 2380



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 41/178 (23%), Positives = 79/178 (44%), Gaps = 15/178 (8%)

Query: 251  RFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
            + I+ P++++  E      +  VS    P V W+     ++  D H++ VSE+ +H L+ 
Sbjct: 2750 KIIKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKSVEIKPSDKHRL-VSERKVHKLML 2807

Query: 311  EVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLEC 370
            + +  SDAG Y  V      +A   V+   + K  K     I  P++K      +   EC
Sbjct: 2808 QNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKN----IEVPETK------TASFEC 2857

Query: 371  QISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            ++S    P + W +N   ++ +     + Q    +  L+I + + +D+  YT    N+
Sbjct: 2858 EVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQ--LIIMNTSTEDSAEYTFVCGND 2912



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 40/148 (27%), Positives = 68/148 (45%), Gaps = 12/148 (8%)

Query: 225   SQVRSRSTSRGDVN--------DQDAIQEKFYPPRF---IQVPENMSIDEGRFCRMDFKV 273
             +Q + R+ +R  VN        D   I  +  PPR    + +   +++  G    +D  V
Sbjct: 12955 AQYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATV 13014

Query: 274   SGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEAT 333
              G P P VSW  +G  ++  +  KM + ++ L +L    V   D+G Y   A+N +G  +
Sbjct: 13015 FGKPMPTVSWKKDGTLLKPAEGIKMAM-QRNLCTLELFSVNRKDSGDYTITAENSSGSKS 13073

Query: 334   FTVQLDVLAKEHKRAPMFIYKPQSKKVL 361
              T++L VL K    A + I K  S + +
Sbjct: 13074 ATIKLKVLDKPGPPASVKINKMYSDRAM 13101



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 34/123 (27%), Positives = 59/123 (47%), Gaps = 6/123 (4%)

Query: 325   AKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAIPPPKLF 381
             A+N  GE T + ++ V+A++   AP    K          E  + +L+  I   P P + 
Sbjct: 13652 AENENGEGTPS-EITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVS 13710

Query: 382   WKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVT 441
             WK+  + +  +T R+S+ + +    TL++ D  K DAG YT++  N AG       + V 
Sbjct: 13711 WKKGEDPLATDT-RVSV-ESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVV 13768

Query: 442   ARP 444
              +P
Sbjct: 13769 GKP 13771



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 49/180 (27%), Positives = 84/180 (46%), Gaps = 25/180 (13%)

Query: 250  PRFIQVPENMS---IDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQ-SDDLHKMIVSEKGL 305
            PR I + + +S   + EG   +++ KVS L + +  W  +G+ VQ SD +H  IV +K  
Sbjct: 2307 PRPIAILQGLSDQKVCEGDIVQLEVKVS-LESVEGVWMKDGQEVQPSDRVH--IVIDKQS 2363

Query: 306  HSLIFEVVRASDAGAYA----CVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL 361
            H L+ E +   DAG Y+     +  + +G  +    +DV+       P+     +   V+
Sbjct: 2364 HMLLIEDMTKEDAGNYSFTIPALGLSTSGRVS-VYSVDVIT------PL-----KDVNVI 2411

Query: 362  EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWY 421
            EG    LEC++S      + W  N+E ++   DR+      T +  L+I   +  D G Y
Sbjct: 2412 EGTKAVLECKVSVPDVTSVKWYLNDEQIK-PDDRVQAIVKGT-KQRLVINRTHASDEGPY 2469



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 28/96 (29%), Positives = 46/96 (47%), Gaps = 1/96 (1%)

Query: 348  APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
            AP    + QS+ V +G       ++   P P+  W +N   ++  +DRI  Y        
Sbjct: 2031 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIE-RSDRIYWYWPEDNVCE 2089

Query: 408  LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTAR 443
            L+I+DV  +D+    V A+N AG T+ +  L V A+
Sbjct: 2090 LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAK 2125



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 41/174 (23%), Positives = 71/174 (40%), Gaps = 19/174 (10%)

Query: 263  EGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYA 322
            EG    +      +P P VSW+ +G+ V++ D   M       H  + + VRA DAG Y 
Sbjct: 8095 EGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRA-DAGIYT 8153

Query: 323  CVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPP----- 377
               +N+ G AT ++ + V+                K +   D  K  C+++  PP     
Sbjct: 8154 ITLENKLGSATASINVKVIG----------LPGPCKDIKASDITKSSCKLTWEPPEFDGG 8203

Query: 378  -PKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
             P L +          T    +  +N  +++  +KD+      ++ V AVN+ G
Sbjct: 8204 TPILHYVLERREAGRRTYIPVMSGEN--KLSWTVKDLIPNGEYFFRVKAVNKVG 8255



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 24/86 (27%), Positives = 45/86 (52%), Gaps = 2/86 (2%)

Query: 359   KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
             K   G SVKL   IS  P P + W ++++ +Q  T+ +   ++ T   ++LIKD ++ ++
Sbjct: 20578 KYRAGTSVKLRAGISGKPAPTIEWYKDDKELQ--TNALVCVENTTDLASILIKDADRLNS 20635

Query: 419   GWYTVSAVNEAGVTTCNTRLDVTARP 444
             G Y +   N  G  +   R+ +  +P
Sbjct: 20636 GCYELKLRNAMGSASATIRVQILDKP 20661



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 52/193 (26%), Positives = 79/193 (40%), Gaps = 18/193 (9%)

Query: 251  RFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
            +F+   E+ ++ EG       ++S      V W+ N   + +     +I SE   H L  
Sbjct: 5270 KFMSPLEDQTVKEGETATFVCELSH-EKMHVVWFKNDAKLHTSRT-VLISSEGKTHKLEM 5327

Query: 311  EVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLEC 370
            + V   D        K    E + T QL VL  +    P F  K   K  +E D + L+C
Sbjct: 5328 KEVTLDDISQIKAQVK----ELSSTAQLKVLEAD----PYFTVKLHDKTAVEKDEITLKC 5379

Query: 371  QISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
            ++S   P K F K   E+V   + + S+  D   R+ L IK  + KD G Y    V + G
Sbjct: 5380 EVSKDVPVKWF-KDGEEIVP--SPKYSIKADGLRRI-LKIKKADLKDKGEY----VCDCG 5431

Query: 431  VTTCNTRLDVTAR 443
                   + V AR
Sbjct: 5432 TDKTKANVTVEAR 5444



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 27/101 (26%), Positives = 43/101 (42%), Gaps = 4/101 (3%)

Query: 244   QEKFYPPRF---IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIV 300
             QEK  PP     +++ E + +  G   R    + G+P P   W  +G  +++D+ H  + 
Sbjct: 11197 QEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDE-HYTVE 11255

Query: 301   SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
             ++     L  +     D G Y     N AG  T  V L VL
Sbjct: 11256 TDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVL 11296



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 36/144 (25%), Positives = 67/144 (46%), Gaps = 4/144 (2%)

Query: 303   KGLHSLIFEVVRASDAGAYACVAKNRAGEAT-FTVQLDVLAKEHKRAPMFIYKPQSKKVL 361
             K L ++I  + +  +   +  VA N  G +   ++ + ++AK+    P       S  V 
Sbjct: 16879 KSLQAVITNLTQGEEY-LFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQ 16937

Query: 362   EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWY 421
              G  +K+E  IS  P P + W ++   ++  T RI++  D+    TL IK+ +K D G Y
Sbjct: 16938 VGQDLKIEVPISGRPKPTITWTKDGLPLK-QTTRINV-TDSLDLTTLSIKETHKDDGGQY 16995

Query: 422   TVSAVNEAGVTTCNTRLDVTARPN 445
              ++  N  G  T +  +    +P+
Sbjct: 16996 GITVANVVGQKTASIEIVTLDKPD 17019



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 27/106 (25%), Positives = 53/106 (50%), Gaps = 2/106 (1%)

Query: 339  DVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISL 398
            +V+AK+    P    +     V+EG+ + +     A+P P + W ++ + V+  +DR+++
Sbjct: 8072 NVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVK-ASDRLTM 8130

Query: 399  YQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARP 444
              D+      + K V + DAG YT++  N+ G  T +  + V   P
Sbjct: 8131 KNDHISAHLEVPKSV-RADAGIYTITLENKLGSATASINVKVIGLP 8175



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 44/180 (24%), Positives = 77/180 (42%), Gaps = 19/180 (10%)

Query: 321   YACVAKNRAGEATFTVQLD----VLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQIS 373
             +  +A+N AG   F+   D    + A++   AP     P+ K V+    G++  LE  I 
Sbjct: 18370 FRVIARNAAGN--FSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIR 18427

Query: 374   AIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTT 433
               P P + W ++ + ++    R+ + +    + TL++KD  + D G Y +   N  G  +
Sbjct: 18428 GKPIPDVVWSKDGKELEETAARMEI-KSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKS 18486

Query: 434   CNTRLDVTARPNQTLPAPKQLRVRPTFSK--YLA----LNGKGLNVKQAFNPEGEFQRLA 487
                 + V  RP    P    L+V    ++  YLA    L   G N+      + E  RL+
Sbjct: 18487 IPITVKVLDRPG---PPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLS 18543



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 51/200 (25%), Positives = 85/200 (42%), Gaps = 25/200 (12%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P  F++  E+ ++ E        ++S   A +V WY NGR ++    +K    +  +H L
Sbjct: 6517 PTEFVEHLEDQTVTEFDDAVFSCQLSREKA-NVKWYRNGREIKEGKKYKF-EKDGSIHRL 6574

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL---EGDS 365
            I +  R  D   YAC  ++R   A   V  + +  E  R P  I +     V+   E + 
Sbjct: 6575 IIKDCRLDDECEYACGVEDRKSRARLFV--EEIPVEIIRPPQDILEAPGADVVFLAELNK 6632

Query: 366  VKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV-TLLIKDVNKKDAGWYTVS 424
             K+E Q          W RNN MV    D+  +  +  G++  L I D+  +D G Y   
Sbjct: 6633 DKVEVQ----------WLRNN-MVVVQGDKHQMMSE--GKIHRLQICDIKPRDQGEYRFI 6679

Query: 425  AVNEAGVTTCNTRLDVTARP 444
            A ++        +L++ A P
Sbjct: 6680 AKDK----EARAKLELAAAP 6695



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 32/135 (23%), Positives = 64/135 (47%), Gaps = 6/135 (4%)

Query: 299   IVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSK 358
             I + KGL  ++  +    +   +  +A N AG +       V+ KE    P    +   +
Sbjct: 14709 ITTVKGLECVVRNLTEGEEY-TFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQ 14767

Query: 359   KVL---EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNK 415
             K++    GD++K+E  +   P P + WK+ +++++  T R++     T  + L I +  +
Sbjct: 14768 KLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILK-QTQRVNFETTATSTI-LNINECVR 14825

Query: 416   KDAGWYTVSAVNEAG 430
              D+G Y ++A N  G
Sbjct: 14826 SDSGPYPLTARNIVG 14840



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 29/102 (28%), Positives = 50/102 (49%), Gaps = 10/102 (9%)

Query: 250  PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYL-------NGRTVQSD-DLHKMIVS 301
            P  I + E M ++EG    +  K+ G+P P ++W+        N   V  D  ++K++V 
Sbjct: 9812 PPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVD 9871

Query: 302  EKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
            +    +L+    R SD G Y   A N  G A+  ++L+VL +
Sbjct: 9872 D--TCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGR 9911



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 34/128 (26%), Positives = 56/128 (43%), Gaps = 8/128 (6%)

Query: 325  AKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSK---KVLEGDSVKLECQISAIPPPKLF 381
            A N AGE        V   E +  P        K   +++ G ++++   ++  P P   
Sbjct: 8773 AVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKV 8832

Query: 382  WKRNNEMVQFNTDRISLYQDNTG-RVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
            W +  E  + + DR+ +  DN G +  L+IKD  +KD G Y ++A N  G      R++V
Sbjct: 8833 WTK--EEGELDKDRVVI--DNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEV 8888

Query: 441  TARPNQTL 448
               P   L
Sbjct: 8889 FDVPGPVL 8896



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 52/193 (26%), Positives = 78/193 (40%), Gaps = 23/193 (11%)

Query: 277   PAPDVSWYLNGRTVQSDDLHK---MIVSEKGLHSLIFEVVRASDAGAYA--CVAKNRAG- 330
             P  D    L G  V+  DL     M  +   +    F V    + G Y     AKN AG 
Sbjct: 13992 PKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGA 14051

Query: 331   -----EATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE---GDSVKLEC-QISAIPPPKLF 381
                  E+T T+    + K+   AP  +  P  K  L    GD++ L    I   P PK  
Sbjct: 14052 ISAPSESTETI----ICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSS 14107

Query: 382   WKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVT 441
             W +  + ++  +D   +    T  + L IK   +KDAG YT++A N  G    + ++ V 
Sbjct: 14108 WSKAGKDIR-PSDITQITSTPTSSM-LTIKYATRKDAGEYTITATNPFGTKVEHVKVTVL 14165

Query: 442   ARPNQTLPAPKQL 454
               P    P P ++
Sbjct: 14166 DVPGP--PGPVEI 14176



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 28/99 (28%), Positives = 46/99 (46%), Gaps = 2/99 (2%)

Query: 243   IQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSE 302
             +  K + P+ ++    +    G    +    SG P P ++W   G+ +  ++ H  ++  
Sbjct: 24716 VPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQ-KGQDLIDNNGHYQVIVT 24774

Query: 303   KGLHSLIF-EVVRASDAGAYACVAKNRAGEATFTVQLDV 340
             +   SL+F   V   DAG Y   AKNR G    TV+LDV
Sbjct: 24775 RSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDV 24813



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 40/169 (23%), Positives = 63/169 (37%), Gaps = 8/169 (4%)

Query: 178  RLTYEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDV 237
            R  + E   R      N A           Q S++   E   +    +    R     DV
Sbjct: 957  REAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDV 1016

Query: 238  --NDQDAIQEKFYP-----PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTV 290
               D    +E+  P     P FI  P    + EG       +V G P P V W  +G  +
Sbjct: 1017 VMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPL 1076

Query: 291  QSDDLHKMIVSEK-GLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQL 338
             +   +K+  +++ G   L+  +  A DAG Y  V +N+ GE + +  L
Sbjct: 1077 TTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 65/252 (25%), Positives = 101/252 (40%), Gaps = 33/252 (13%)

Query: 127  QPINAKPSQTAN-AKPIPRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQRLTYEEKM 185
            QP+  +  + A     I   P  +I   KE   Q L    KCK   LH+G +   Y   +
Sbjct: 3200 QPVTVQSGKPARFCAVISGRPQPKISWYKEE--QLLSTGFKCK--FLHDGQE---YTLLL 3252

Query: 186  ARRLLGPQNAAA-VFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQ 244
                  P++AA    +A++D G   +       A L V   +V S         DQ+   
Sbjct: 3253 IEAF--PEDAAVYTCEAKNDYGVATTS------ASLSVEVPEVVSP--------DQEM-- 3294

Query: 245  EKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG 304
               YPP  I   ++    EG+  R   +VSG     VSWY   + ++     +M   E  
Sbjct: 3295 -PVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQFEDT 3352

Query: 305  LHSLIFEVVRASDAGAYACVAKNRAGE--ATFTVQLDVLAKEHKRAPMFIYK-PQSKKVL 361
                I E     D G Y  VA N  G+  +T  + L+V A + + +   + +  +S+ V 
Sbjct: 3353 YQLEIAEAY-PEDEGTYTFVASNAVGQVSSTANLSLEVQALDRQSSGKDVRESAKSQAVA 3411

Query: 362  EGDSVKLECQIS 373
            +    K E +IS
Sbjct: 3412 DSSFTKEESKIS 3423



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 28/108 (25%), Positives = 48/108 (44%), Gaps = 2/108 (1%)

Query: 244   QEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEK 303
             +E+  PP+ + +PE ++I  G+  R++  V G P P   W   G        H  +    
Sbjct: 12589 KEQLLPPKIL-MPEQITIKAGKKLRIEAHVYGKPHPTCKW-KKGEDEVVTSSHLAVHKAD 12646

Query: 304   GLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMF 351
                 LI + V   D+G Y+  A+N +G  T  +++ V+       P F
Sbjct: 12647 SSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPF 12694



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 27/102 (26%), Positives = 49/102 (48%), Gaps = 6/102 (5%)

Query: 360   VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
             V  G +V L+  +   P P + WK++  +++         Q N    TL +  VN+KD+G
Sbjct: 13002 VKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNL--CTLELFSVNRKDSG 13059

Query: 420   WYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFS 461
              YT++A N +G  +   +L V  +P      P  +++   +S
Sbjct: 13060 DYTITAENSSGSKSATIKLKVLDKPG----PPASVKINKMYS 13097



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 39/150 (26%), Positives = 63/150 (42%), Gaps = 17/150 (11%)

Query: 231   STSRGDVNDQDAIQEKFYPPRFIQVP---ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNG 287
             S S G +  +D +     PPR    P   + + +  G   ++D  + G P P + W + G
Sbjct: 16221 SESTGAITARDEVD----PPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQW-IKG 16275

Query: 288   RTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKR 347
                 S+     I S     SL  +     D+G Y   AKN AGE + TV + VL +    
Sbjct: 16276 DQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPG-- 16333

Query: 348   APMFIYKPQSKKVLEGDSVKLECQISAIPP 377
                    P+   V+ G + + +C ++  PP
Sbjct: 16334 ------PPEGPVVISGVTAE-KCTLAWKPP 16356



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 21/86 (24%), Positives = 36/86 (41%)

Query: 355   PQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVN 414
             P    + EG  + + C  +  P P++ W      +          ++     TL+I DV 
Sbjct: 27030 PSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQ 27089

Query: 415   KKDAGWYTVSAVNEAGVTTCNTRLDV 440
             K+D G YT+S  NE G  +    + +
Sbjct: 27090 KQDGGLYTLSLGNEFGSDSATVNIHI 27115



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 42/204 (20%), Positives = 72/204 (35%), Gaps = 37/204 (18%)

Query: 274   SGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAG--- 330
             S L A +V+WY +G+ ++ +   +   S  G + L    +  SD G Y C      G   
Sbjct: 26437 SVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSK 26496

Query: 331   -------------------------------EATFTVQLDVLAKEH-KRAPMFIYKPQSK 358
                                            E+T T + +  A E     P+ +   Q  
Sbjct: 26497 TNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDT 26556

Query: 359   KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
              V      K   + +  P P   W ++ + +     +  L +D  G   L I   +  D+
Sbjct: 26557 TVSSDSVAKFAVKATGEPRPTAIWTKDGKAIT-QGGKYKLSEDK-GGFFLEIHKTDTSDS 26614

Query: 419   GWYTVSAVNEAGVTTCNTRLDVTA 442
             G YT +  N AG  + + +L + A
Sbjct: 26615 GLYTCTVKNSAGSVSSSCKLTIKA 26638



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 30/129 (23%), Positives = 60/129 (46%), Gaps = 7/129 (5%)

Query: 321   YACVAKNRAGEATFTVQLD--VLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAI 375
             +  +AKN AG  +   +    +  ++   AP      + K  +    G++ +LE  +S  
Sbjct: 15124 FRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGR 15183

Query: 376   PPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCN 435
             PPP + W ++ + ++  T ++ +   +     L+ KD  ++D+G YT++A N  G     
Sbjct: 15184 PPPTMEWSKDGKELE-GTAKLEIKIADFS-TNLVNKDSTRRDSGAYTLTATNPGGFAKHI 15241

Query: 436   TRLDVTARP 444
               + V  RP
Sbjct: 15242 FNVKVLDRP 15250



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 26/95 (27%), Positives = 45/95 (47%), Gaps = 2/95 (2%)

Query: 336   VQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDR 395
             + + V+AK+    P F     +  VL G+ +K++      P P + W ++N  ++  T R
Sbjct: 15830 LSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLK-QTTR 15888

Query: 396   ISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
             ++  +       L IKD  ++D G Y V   N AG
Sbjct: 15889 VNA-ESTENNSLLTIKDACREDVGHYVVKLTNSAG 15922



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 21/86 (24%), Positives = 38/86 (44%), Gaps = 1/86 (1%)

Query: 257   ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRAS 316
             ++ ++      +   K +G P P   W  +G+ +     +K+   +KG   L       S
Sbjct: 26554 QDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLS-EDKGGFFLEIHKTDTS 26612

Query: 317   DAGAYACVAKNRAGEATFTVQLDVLA 342
             D+G Y C  KN AG  + + +L + A
Sbjct: 26613 DSGLYTCTVKNSAGSVSSSCKLTIKA 26638



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 39/163 (23%), Positives = 66/163 (40%), Gaps = 16/163 (9%)

Query: 281  VSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
            V W+ N + + +     M   E   HS+ F+ +   D       A   + EA  TV    
Sbjct: 5654 VKWFKNDQRLHTTRSVSM-QDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVL--- 5709

Query: 341  LAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQ 400
                 +  P F  K Q    +E D V L+C+IS    P  ++K   E+      + ++ +
Sbjct: 5710 -----EGDPYFTGKLQDYTGVEKDEVILQCEISKADAPVKWFKDGKEI---KPSKNAVIK 5761

Query: 401  DNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTAR 443
             +  +  L++K   K D G YT     + G    + +LD+  R
Sbjct: 5762 ADGKKRMLILKKALKSDIGQYTC----DCGTDKTSGKLDIEDR 5800



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 32/142 (22%), Positives = 62/142 (43%), Gaps = 14/142 (9%)

Query: 306   HSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL---E 362
             H   F V+  + AG ++  +++            + A++    P     P+ K  +    
Sbjct: 16202 HRYEFRVIARNAAGVFSEPSESTGA---------ITARDEVDPPRISMDPKYKDTIVVHA 16252

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G+S K++  I   P P + W + ++ +  NT R+ +   +    +L +KD  + D+G Y 
Sbjct: 16253 GESFKVDADIYGKPIPTIQWIKGDQELS-NTARLEIKSTDFA-TSLSVKDAVRVDSGNYI 16310

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             + A N AG  +    + V  RP
Sbjct: 16311 LKAKNVAGERSVTVNVKVLDRP 16332



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 30/129 (23%), Positives = 58/129 (44%), Gaps = 7/129 (5%)

Query: 321   YACVAKNRAGEATFTVQLD--VLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAI 375
             +  +AKN AG  +        + AK+    P     P+ +  +    G++ +LE  +   
Sbjct: 17288 FRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGK 17347

Query: 376   PPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCN 435
             P P + W R ++ ++  + R  + ++   +  L++KD  + D G Y + A N AG  +  
Sbjct: 17348 PLPTIEWLRGDKEIE-ESARCEI-KNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFP 17405

Query: 436   TRLDVTARP 444
               + V  RP
Sbjct: 17406 VNVKVLDRP 17414



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 24/98 (24%), Positives = 41/98 (41%)

Query: 250   PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
             P F ++  N    EG+    + +VSG+P P + W  +G+ +      ++I      ++L 
Sbjct: 25490 PMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALH 25549

Query: 310   FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKR 347
                    D G Y   A N AG  +    L V    +K+
Sbjct: 25550 IRDTLPEDTGYYRVTATNTAGSTSCQAHLQVERLRYKK 25587



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 40/158 (25%), Positives = 61/158 (38%), Gaps = 13/158 (8%)

Query: 277  PAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTV 336
            P   V W  + + +Q  D  K I  EK +H L+    R SDAG Y  VA      A   V
Sbjct: 3038 PDITVQWMKDDQELQITDRIK-IQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFV 3096

Query: 337  Q-LDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDR 395
            +  DV  +  K+    I K ++    E +   ++            W ++   + F    
Sbjct: 3097 EGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAH----------WYKDGIEINFQVQE 3146

Query: 396  ISLYQDNTGRVTLLIKDVNKKDAGWYT-VSAVNEAGVT 432
               Y        + I +  + DAG YT V+  N + VT
Sbjct: 3147 RHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVT 3184



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 23/82 (28%), Positives = 42/82 (51%), Gaps = 2/82 (2%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G ++++  ++   P P + W +  +++     R+ L QD   RV L IK+  + D G Y 
Sbjct: 11618 GQTIRILARVKGRPEPDITWTKEGKVL-VREKRVDLIQD-LPRVELQIKEAVRADHGKYI 11675

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             +SA N +G    +  ++V  RP
Sbjct: 11676 ISAKNSSGHAQGSAIVNVLDRP 11697



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)

Query: 268   RMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKN 327
             R+   + G PAP VSW   G    + D    + S     +LI    + SDAG Y    KN
Sbjct: 13696 RLKIPIKGKPAPSVSWK-KGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKN 13754

Query: 328   RAGEATFTVQLDVLAK 343
              AG    T+ + V+ K
Sbjct: 13755 VAGTKEGTISIKVVGK 13770



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 21/91 (23%), Positives = 46/91 (50%), Gaps = 1/91 (1%)

Query: 253   IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEV 312
             ++  E +    G   ++   +SG PAP + WY + + +Q++ L   + +   L S++ + 
Sbjct: 20571 LEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNAL-VCVENTTDLASILIKD 20629

Query: 313   VRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
                 ++G Y    +N  G A+ T+++ +L K
Sbjct: 20630 ADRLNSGCYELKLRNAMGSASATIRVQILDK 20660



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 6/83 (7%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKD-VNKKDAGWY 421
             G S++L   +S  PPP + W +    +   +  I    D T   +LLI D VN+ DAG Y
Sbjct: 23156 GASLRLMVSVSGRPPPVITWSKQG--IDLASRAII---DTTESYSLLIVDKVNRYDAGKY 23210

Query: 422   TVSAVNEAGVTTCNTRLDVTARP 444
             T+ A N++G  +    + V   P
Sbjct: 23211 TIEAENQSGKKSATVLVKVYDTP 23233



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 23/85 (27%), Positives = 42/85 (49%), Gaps = 2/85 (2%)

Query: 360  VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
            V  G  ++L   ++  P PK+ W +  +M+     RI++ ++   + T+ I D  + D G
Sbjct: 7397 VKAGTKIELPATVTGKPEPKITWTKA-DMILKQDKRITI-ENVPKKSTVTIVDSKRSDTG 7454

Query: 420  WYTVSAVNEAGVTTCNTRLDVTARP 444
             Y + AVN  G  T    ++V  +P
Sbjct: 7455 TYIIEAVNVCGRATAVVEVNVLDKP 7479



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 36/140 (25%), Positives = 63/140 (45%), Gaps = 12/140 (8%)

Query: 321   YACVAKNRAGEATFT-VQLDVLAKEHKRAPMFIYKP---QSKKVLEGDSVKLECQISAIP 376
             +  +A N AGE+    V   VL K+    P  I      + + +  GD+++L   I  +P
Sbjct: 10882 FRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVP 10941

Query: 377   PPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
              PK+ WK+ +        RI +    +    L I++   +D G Y+++  N AG  T + 
Sbjct: 10942 FPKVTWKKEDRDAPTKA-RIDVTPVGS---KLEIRNAAHEDGGIYSLTVENPAGSKTVSV 10997

Query: 437   RLDVTARPNQTLPAPKQLRV 456
             ++ V  +P      P+ L V
Sbjct: 10998 KVLVLDKPG----PPRDLEV 11013



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 37/128 (28%), Positives = 62/128 (48%), Gaps = 14/128 (10%)

Query: 325   AKNRAGEAT-FTVQLDVLAKEHKRAP---MFIYKPQSKKVLEGDSVKLECQISAIPPPKL 380
             A+N+AG +    + L VL KE    P   M  +   +  V  G ++K++  IS  P PK+
Sbjct: 20144 AENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKV 20203

Query: 381   FWKRNN----EMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
                R+       ++FNT+   +  +N   +T+ +K+    DAG Y ++A N +G T    
Sbjct: 20204 TLSRDGVPLKATMRFNTE---ITAEN---LTINLKESVTADAGRYEITAANSSGTTKAFI 20257

Query: 437   RLDVTARP 444
              + V  RP
Sbjct: 20258 NIVVLDRP 20265



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 25/83 (30%), Positives = 42/83 (50%), Gaps = 1/83 (1%)

Query: 259   MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDA 318
             +++  G+  R+  +V G P PD++W   G+ +  +    +I     +   I E VRA D 
Sbjct: 11613 ITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRA-DH 11671

Query: 319   GAYACVAKNRAGEATFTVQLDVL 341
             G Y   AKN +G A  +  ++VL
Sbjct: 11672 GKYIISAKNSSGHAQGSAIVNVL 11694



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 56/245 (22%), Positives = 99/245 (40%), Gaps = 21/245 (8%)

Query: 106   DYNSSKIPSAMDSN---YQQSSAGQPINAKPSQ-TANAKPI--PRTPDHEIQGSKEALIQ 159
             +Y ++ +   +D     Y ++SAG    + PS+ T    P+  P TPD+ I  ++E +  
Sbjct: 21510 EYRATGLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDY-IDVTRETIT- 21567

Query: 160   DLERKLKCKDTLLHNGNQRLTY--EEKMARRLLGPQNAAAVFQAQDD-SGAQDSQQHNSE 216
                  LK    L   G++ + Y  E++         N   V + Q   +G     ++   
Sbjct: 21568 -----LKWNPPLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFR 21622

Query: 217   H-ARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSG 275
               AR  V T    S+S+      D++      + P +    + + I  G   R+   V G
Sbjct: 21623 IIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYF---DGLIIKSGESLRIKALVQG 21679

Query: 276   LPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFT 335
              P P V+W+ +G  ++   ++  I    G  SL          G Y   AKN +G A   
Sbjct: 21680 RPVPRVTWFKDGVEIEK-RMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAE 21738

Query: 336   VQLDV 340
             +++ V
Sbjct: 21739 IKVKV 21743



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 23/75 (30%), Positives = 37/75 (49%), Gaps = 1/75 (1%)

Query: 269   MDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNR 328
             +D  +SG PAP V+W L    ++  D    I + K   +L  +     D+G Y    +N 
Sbjct: 22362 IDVPISGRPAPKVTWKLEEMRLKETD-RVSITTTKDRTTLTVKDSMRGDSGRYFLTLENT 22420

Query: 329   AGEATFTVQLDVLAK 343
             AG  TF+V + V+ +
Sbjct: 22421 AGVKTFSVTVVVIGR 22435



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 42/153 (27%), Positives = 60/153 (39%), Gaps = 16/153 (10%)

Query: 276  LPAPDV--SWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEAT 333
            L  PDV   W L G+ + +    ++I   K  H LI    +    G  +  A N    A 
Sbjct: 5469 LSEPDVHGQWKLKGQPLTASPDCEIIEDGKK-HILILHNCQLGMTGEVSFQAANAKSAAN 5527

Query: 334  FTVQLDVLAKEHKRAPMFIYKPQSK-KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFN 392
              V         K  P+    P S  KV E D  K EC++S  P    + K   E+    
Sbjct: 5528 LKV---------KELPLIFITPLSDVKVFEKDEAKFECEVSREPKTFRWLKGTQEIT--G 5576

Query: 393  TDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSA 425
             DR  L +D T + +++IK    +D   Y   A
Sbjct: 5577 DDRFELIKDGT-KHSMVIKSAAFEDEAKYMFEA 5608



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 26/138 (18%), Positives = 62/138 (44%), Gaps = 9/138 (6%)

Query: 317   DAGAYACVAKNRAGEATFTVQLD--VLAKEHKRAPMFIYKPQ---SKKVLEGDSVKLECQ 371
             D   +  +A+N  G  +   Q    ++ ++    P+  + P+      +  G+S++++  
Sbjct: 21617 DRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKAL 21676

Query: 372   ISAIPPPKLFWKRNNEMVQFNTDRISL-YQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
             +   P P++ W ++   ++    R+++   D  G  +L ++D  +   G YTV A N +G
Sbjct: 21677 VQGRPVPRVTWFKDGVEIE---KRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASG 21733

Query: 431   VTTCNTRLDVTARPNQTL 448
                   ++ V   P + +
Sbjct: 21734 SAKAEIKVKVQDTPGKVV 21751



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 21/82 (25%), Positives = 41/82 (50%), Gaps = 2/82 (2%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G  + L+  +   P PK+ W + ++ +    +++SL Q    R T +IK  ++ D+G YT
Sbjct: 22757 GSDLVLDAAVGGKPEPKIIWTKGDKELDL-CEKVSL-QYTGKRATAVIKFCDRSDSGKYT 22814

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             ++  N +G    +  + V   P
Sbjct: 22815 LTVKNASGTKAVSVMVKVLDSP 22836



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 25/84 (29%), Positives = 42/84 (50%), Gaps = 3/84 (3%)

Query: 257   ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRAS 316
             + ++I  G   R+   VSG P P ++W   G  + S     +I + +    LI + V   
Sbjct: 23149 KTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLAS---RAIIDTTESYSLLIVDKVNRY 23205

Query: 317   DAGAYACVAKNRAGEATFTVQLDV 340
             DAG Y   A+N++G+ + TV + V
Sbjct: 23206 DAGKYTIEAENQSGKKSATVLVKV 23229



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 29/115 (25%), Positives = 42/115 (36%), Gaps = 12/115 (10%)

Query: 348   APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
             A   + KP+S  V EG+S +  C     P P + W R  +++  +T           + T
Sbjct: 26255 AARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVL--STSARHQVTTTKYKST 26312

Query: 408   LLIKDVNKKDAGWYTVSAVNEAGVTTCN----------TRLDVTARPNQTLPAPK 452
               I  V   D G Y+V   N  G               T   VT+ P    P P+
Sbjct: 26313 FEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPR 26367



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 24/69 (34%), Positives = 37/69 (53%), Gaps = 4/69 (5%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLL-IKDVNKKDAGWY 421
             G +++L   +   PPPK+ W + N  ++   DRI L   +T   T L  ++VNK DAG Y
Sbjct: 13403 GVTMRLYVPVKGRPPPKITWSKPNVNLR---DRIGLDIKSTDFDTFLRCENVNKYDAGKY 13459

Query: 422   TVSAVNEAG 430
              ++  N  G
Sbjct: 13460 ILTLENSCG 13468



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 27/92 (29%), Positives = 43/92 (46%), Gaps = 11/92 (11%)

Query: 341   LAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTD-RI 396
             +AKE +  P+F    + +K L    G S  +       P P + W + +      TD R 
Sbjct: 19871 IAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPD------TDLRT 19924

Query: 397   SLYQDNT-GRVTLLIKDVNKKDAGWYTVSAVN 427
               Y D T  R +L I++ N+ D+G YT++  N
Sbjct: 19925 RAYVDTTDSRTSLTIENANRNDSGKYTLTIQN 19956



 Score = 37.4 bits (85), Expect = 0.032
 Identities = 27/99 (27%), Positives = 41/99 (41%), Gaps = 3/99 (3%)

Query: 248   YPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQ-SDDLHKMIVSEKGLH 306
             + PR      +  +  G+  R    V   P  +V WY NG  +Q S  +H    +  G+ 
Sbjct: 26067 HAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIH--YTNTSGVL 26124

Query: 307   SLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEH 345
             +L        D+G Y  V  N  GEA+    LDV   ++
Sbjct: 26125 TLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDY 26163



 Score = 37.0 bits (84), Expect = 0.042
 Identities = 26/93 (27%), Positives = 45/93 (48%), Gaps = 4/93 (4%)

Query: 253   IQVPENM-SIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI-F 310
             +++P N  SI  G   +++  V G P P++SW  +G  ++     ++ V E    +++  
Sbjct: 18009 LKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTT--RVNVEETATSTVLHI 18066

Query: 311   EVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
             +     D G Y   A N AG AT  + + VL K
Sbjct: 18067 KEGNKDDFGKYTVTATNSAGTATENLSVIVLEK 18099



 Score = 37.0 bits (84), Expect = 0.042
 Identities = 28/120 (23%), Positives = 54/120 (45%), Gaps = 8/120 (6%)

Query: 227   VRSRSTSRGDVNDQDAIQEKFYPPRF---IQVPENMSIDEGRFCRMDFKVSGLPAPDVSW 283
             V   S S G +  +D ++    PPR    ++  + + +  G   +++  ++G P P +SW
Sbjct: 19463 VSEPSESTGPIIVKDDVE----PPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISW 19518

Query: 284   YLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
               +G  ++     ++I ++      + + +R  D G Y    KN AG  +  V   VL K
Sbjct: 19519 AKDGIEIEERARTEIISTDNHTLLTVKDCIR-RDTGQYVLTLKNVAGTRSVAVNCKVLDK 19577



 Score = 36.6 bits (83), Expect = 0.054
 Identities = 38/139 (27%), Positives = 63/139 (45%), Gaps = 15/139 (10%)

Query: 325   AKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAIPPPKLF 381
             A N AG     V  DV   E + AP F    + ++ L    G S+++   I   P P++ 
Sbjct: 14445 AINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVT 14504

Query: 382   WKRNNEMVQFNTDRISLYQDNTGRVTLL-IKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
             W ++N  ++   +R ++  +NT   TLL I + N+ D G + ++  N AG  +    + V
Sbjct: 14505 WTKDNINLK---NRANI--ENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRV 14559

Query: 441   TARPNQTLPAPKQLRVRPT 459
                P         L +RPT
Sbjct: 14560 LDTPGPV------LNLRPT 14572



 Score = 36.6 bits (83), Expect = 0.054
 Identities = 30/132 (22%), Positives = 55/132 (41%), Gaps = 5/132 (3%)

Query: 347   RAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV 406
             +AP F  + ++  V    +  L C+++  P P + W R  + +  +  +  + +   G  
Sbjct: 24621 QAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYH 24680

Query: 407   TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLAL 466
              L+I  V   DA  Y V A N+ G  +    L+V       LP     +         AL
Sbjct: 24681 QLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLP-----KTLEGMGAVHAL 24735

Query: 467   NGKGLNVKQAFN 478
              G+ +++K  F+
Sbjct: 24736 RGEVVSIKIPFS 24747



 Score = 35.8 bits (81), Expect = 0.093
 Identities = 30/120 (25%), Positives = 56/120 (46%), Gaps = 12/120 (10%)

Query: 231  STSRGDVNDQDAIQEKFYPPRFIQV--PENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGR 288
            S + G++   D IQE+  P  FI +   + +    G   R+   + G P P  SW  +G+
Sbjct: 9488 SDTTGEIPATD-IQEE--PEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSWEFDGK 9544

Query: 289  TVQS--DDLHKM-----IVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
              ++  D +H +     + + +    +I    + S  G Y+  AKN+AG+ T   ++ V+
Sbjct: 9545 AKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVM 9604



 Score = 35.8 bits (81), Expect = 0.093
 Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 5/95 (5%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
             P   +   + ++I  G    +  + SG P P VSW+ +   V  DD   +  +     +L
Sbjct: 10513 PTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPA---TL 10569

Query: 309   IFEVVRA--SDAGAYACVAKNRAGEATFTVQLDVL 341
               E ++A  SD+G Y  V +N  G      Q++V+
Sbjct: 10570 ALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVV 10604



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 24/100 (24%), Positives = 44/100 (44%), Gaps = 10/100 (10%)

Query: 363  GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT------LLIKDVNKK 416
            G  +++   I   P PK  W+ + +  +   D +    ++    T      ++I +  + 
Sbjct: 9520 GSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRS 9579

Query: 417  DAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRV 456
              G Y+++A N+AG  T N R+ V   P      PK L+V
Sbjct: 9580 HTGKYSITAKNKAGQKTANCRVKVMDVPG----PPKDLKV 9615



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 42/166 (25%), Positives = 70/166 (42%), Gaps = 16/166 (9%)

Query: 298   MIVSEKGLHSLIFEVVRASDAGAY--ACVAKNRAGEATFT-VQLDVLAKEHKRAPMFIYK 354
             M     G++    EV +  +   Y     A N+AG      V   ++ +E   AP     
Sbjct: 16581 MCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLD 16640

Query: 355   PQSKKVLE---GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIK 411
              + +K++    G S++L   I   P P++ W + +  +     R +   D T   T L+ 
Sbjct: 16641 LELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEI-----RDAAIIDVTSSFTSLVL 16695

Query: 412   D-VNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRV 456
             D VN+ D+G YT++  N +G  +      VT R   T   P  L+V
Sbjct: 16696 DNVNRYDSGKYTLTLENSSGTKSA----FVTVRVLDTPSPPVNLKV 16737



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 25/110 (22%), Positives = 50/110 (45%), Gaps = 2/110 (1%)

Query: 340   VLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLY 399
             V+A++ +  P       +  V   + +K++      P   + W+++ + ++  T R+++ 
Sbjct: 19081 VIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLK-ETTRVNVS 19139

Query: 400   QDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLP 449
                T   +L IK+ +K+D G Y +   N AG  T    + V  RP    P
Sbjct: 19140 SSKTV-TSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGP 19188



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 25/94 (26%), Positives = 43/94 (45%), Gaps = 2/94 (2%)

Query: 348   APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
             AP    + +S +V  G + +    + + P  ++ W  N   +Q  + +I  Y + +G +T
Sbjct: 26068 APRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQ-ESSKIH-YTNTSGVLT 26125

Query: 408   LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVT 441
             L I D +  D+G Y     N  G  +    LDVT
Sbjct: 26126 LEILDCHTDDSGTYRAVCTNYKGEASDYATLDVT 26159



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 26/114 (22%), Positives = 50/114 (43%), Gaps = 8/114 (7%)

Query: 231   STSRGDVNDQDAIQEKFYPPRFIQVP---ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNG 287
             S S G +  +D ++     PR    P   + + ++ G   R++  V G P P + W    
Sbjct: 17303 SDSTGPITAKDEVEL----PRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGD 17358

Query: 288   RTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
             + ++     ++  ++     ++ + +R  D G Y   A N AG  +F V + VL
Sbjct: 17359 KEIEESARCEIKNTDFKALLIVKDAIRI-DGGQYILRASNVAGSKSFPVNVKVL 17411



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 22/104 (21%), Positives = 44/104 (42%), Gaps = 5/104 (4%)

Query: 240   QDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMI 299
             +D + E    P F     + S+  G+  +++  +SG P P ++W  +G  ++       +
Sbjct: 16919 KDLVIEPDVKPAF----SSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLK-QTTRINV 16973

Query: 300   VSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
                  L +L  +     D G Y     N  G+ T ++++  L K
Sbjct: 16974 TDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDK 17017



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 22/69 (31%), Positives = 34/69 (49%), Gaps = 3/69 (4%)

Query: 257  ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGL-HSLIFEVVRA 315
            +++++ EG    ++ KVS      V WYLN   ++ DD  + IV  KG    L+     A
Sbjct: 2406 KDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIV--KGTKQRLVINRTHA 2463

Query: 316  SDAGAYACV 324
            SD G Y  +
Sbjct: 2464 SDEGPYKLI 2472



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 27/126 (21%), Positives = 55/126 (43%), Gaps = 12/126 (9%)

Query: 253   IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEV 312
             ++  + + +  G   R++  VSG P P + W  +G+ ++     ++ +++    +L+ + 
Sbjct: 15160 VKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFST-NLVNKD 15218

Query: 313   VRASDAGAYACVAKNRAGEATFTVQLDVLAKE-HKRAPMFIYKPQSKKVLEGDSVKLECQ 371
                 D+GAY   A N  G A     + VL +      P+ + +  S+K          C 
Sbjct: 15219 STRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEK----------CV 15268

Query: 372   ISAIPP 377
             +S  PP
Sbjct: 15269 LSWFPP 15274



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 20/85 (23%), Positives = 37/85 (43%), Gaps = 2/85 (2%)

Query: 360   VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
             V  G+ +K+   I+  P P + W ++   ++       +  DN     L +KD  ++D G
Sbjct: 19496 VKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDN--HTLLTVKDCIRRDTG 19553

Query: 420   WYTVSAVNEAGVTTCNTRLDVTARP 444
              Y ++  N AG  +      V  +P
Sbjct: 19554 QYVLTLKNVAGTRSVAVNCKVLDKP 19578



 Score = 33.9 bits (76), Expect = 0.35
 Identities = 39/137 (28%), Positives = 60/137 (43%), Gaps = 11/137 (8%)

Query: 362  EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKD-AGW 420
            EGD V L   I+     ++ W   N++V  +     L   NT   TL+I  VN +D  G 
Sbjct: 4448 EGDIVHLTTSITNAK--EVNWYFENKLVPSDEKFKCLQDQNT--YTLVIDKVNTEDHQGE 4503

Query: 421  YTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNPE 480
            Y   A+N++G T  + +L V  R     P  K+ ++ P       L      ++ A  P 
Sbjct: 4504 YVCEALNDSGKTATSAKLTVVKR---AAPVIKR-KIEPLEVALGHLAKFTCEIQSA--PN 4557

Query: 481  GEFQRLAAQSGLYESEE 497
              FQ   A   +YES++
Sbjct: 4558 VRFQWFKAGREIYESDK 4574



 Score = 33.9 bits (76), Expect = 0.35
 Identities = 22/94 (23%), Positives = 37/94 (39%), Gaps = 4/94 (4%)

Query: 356   QSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNK 415
             Q+  V  G S++L       P P   W + +  +    D            TL +++ N+
Sbjct: 22060 QTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRAD----IHTTDSFSTLTVENCNR 22115

Query: 416   KDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLP 449
              DAG YT++  N +G  +    + V   P    P
Sbjct: 22116 NDAGKYTLTVENNSGSKSITFTVKVLDTPGPPGP 22149



 Score = 33.5 bits (75), Expect = 0.46
 Identities = 36/159 (22%), Positives = 62/159 (38%), Gaps = 16/159 (10%)

Query: 198   VFQAQDDSGAQDSQQHNSEHARLQVP------TSQVRSRSTSRGDVNDQDAIQEKFYPPR 251
             V +A  D+  + +   N +  R +V         Q R  + ++   +D   + +K YP  
Sbjct: 13322 VKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKD 13381

Query: 252   FIQVPEN---------MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSE 302
              +  PE          + +  G   R+   V G P P ++W      ++ D +   I S 
Sbjct: 13382 ILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLR-DRIGLDIKST 13440

Query: 303   KGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
                  L  E V   DAG Y    +N  G+  +T+ + VL
Sbjct: 13441 DFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVL 13479



 Score = 33.1 bits (74), Expect = 0.60
 Identities = 23/85 (27%), Positives = 38/85 (44%), Gaps = 2/85 (2%)

Query: 360   VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
             V  G +V+    I  +P P   W  +   ++ + +  ++  DN   V L IK+  ++D G
Sbjct: 11217 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTD-EHYTVETDNFSSV-LTIKNCLRRDTG 11274

Query: 420   WYTVSAVNEAGVTTCNTRLDVTARP 444
              Y ++  N AG  T    L V   P
Sbjct: 11275 EYQITVSNAAGSKTVAVHLTVLDVP 11299



 Score = 33.1 bits (74), Expect = 0.60
 Identities = 25/95 (26%), Positives = 39/95 (41%), Gaps = 1/95 (1%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
             PP F  +    ++  G   ++D    G P P V+W+ +   ++         +E      
Sbjct: 15842 PPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLT 15901

Query: 309   IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
             I +  R  D G Y     N AGEA  T+ + VL K
Sbjct: 15902 IKDACR-EDVGHYVVKLTNSAGEAIETLNVIVLDK 15935



 Score = 32.7 bits (73), Expect = 0.78
 Identities = 22/95 (23%), Positives = 38/95 (40%), Gaps = 7/95 (7%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
             P + I VP       GR   +   ++G P P  SW+  G  ++  +    + +   +  L
Sbjct: 23439 PQKTIHVPA------GRPVELVIPIAGRPPPAASWFFAGSKLRESE-RVTVETHTKVAKL 23491

Query: 309   IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
                     D G Y    KN  G  + T+++ +L K
Sbjct: 23492 TIRETTIRDTGEYTLELKNVTGTTSETIKVIILDK 23526



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 30/134 (22%), Positives = 44/134 (32%), Gaps = 9/134 (6%)

Query: 216  EHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPP----RFIQVPENMSIDEGRFCRMDF 271
            EH   +     V     S   +     IQ+   PP    R     + + +  G    +  
Sbjct: 9056 EHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPA 9115

Query: 272  KVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHS-----LIFEVVRASDAGAYACVAK 326
             V+GLP P + W  N   ++       I  E+   S     L        D G Y   A 
Sbjct: 9116 DVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTAS 9175

Query: 327  NRAGEATFTVQLDV 340
            NR G     V ++V
Sbjct: 9176 NRLGSVFRNVHVEV 9189



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 33/126 (26%), Positives = 58/126 (46%), Gaps = 8/126 (6%)

Query: 365   SVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIK-DVNKKDAGWYTV 423
             +++L   I   P P++ W R++     + D+ S+  ++T   TLLI  +VN+ D+G Y +
Sbjct: 15572 TLRLFVPIKGRPAPEVKWARDHGE---SLDKASI--ESTSSYTLLIVGNVNRFDSGKYIL 15626

Query: 424   SAVNEAGVTTC--NTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNPEG 481
             +  N +G  +   N R+  T  P Q L   +  +   T +    L   G  +K     + 
Sbjct: 15627 TVENSSGSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVEKR 15686

Query: 482   EFQRLA 487
             E  R A
Sbjct: 15687 ESTRKA 15692



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 23/87 (26%), Positives = 34/87 (39%), Gaps = 1/87 (1%)

Query: 273   VSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEA 332
             + G P P  SW   G+ ++  D+   I S      L  +     DAG Y   A N  G  
Sbjct: 14098 ILGKPLPKSSWSKAGKDIRPSDI-TQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTK 14156

Query: 333   TFTVQLDVLAKEHKRAPMFIYKPQSKK 359
                V++ VL       P+ I    ++K
Sbjct: 14157 VEHVKVTVLDVPGPPGPVEISNVSAEK 14183



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 26/109 (23%), Positives = 46/109 (42%), Gaps = 6/109 (5%)

Query: 236   DVNDQDAIQEKFYPPRF---IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQS 292
             DV     ++EK   P     +++ + ++I  G   R+   + G P P+V W   G+    
Sbjct: 16621 DVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKW---GKVDGE 16677

Query: 293   DDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
                  +I       SL+ + V   D+G Y    +N +G  +  V + VL
Sbjct: 16678 IRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVL 16726



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 20/82 (24%), Positives = 40/82 (48%), Gaps = 2/82 (2%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G  V+L   I+  PPP   W      ++  ++R+++ + +T    L I++   +D G YT
Sbjct: 23448 GRPVELVIPIAGRPPPAASWFFAGSKLR-ESERVTV-ETHTKVAKLTIRETTIRDTGEYT 23505

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             +   N  G T+   ++ +  +P
Sbjct: 23506 LELKNVTGTTSETIKVIILDKP 23527



 Score = 30.8 bits (68), Expect = 3.0
 Identities = 32/153 (20%), Positives = 60/153 (39%), Gaps = 7/153 (4%)

Query: 280  DVSWYLNGRTVQSDDLHKMIVSEKG-LHSLIFEVVRASDAGAYACVAKNRAGEATFTVQL 338
            DV+W   G  ++  +  K   S+ G +  L    V+  D G Y+C+  N  GE T +  L
Sbjct: 3519 DVTWTHEGAKIEESERLKQ--SQNGNIQFLTICNVQLVDQGLYSCIVHNDCGERTTSAVL 3576

Query: 339  DVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDR--- 395
             V           I +    ++ E  S  L  +   +   +L   + NE ++  ++    
Sbjct: 3577 SVEGAPESILHERIEQEIEMEMKEFSSSFLSAEEEGLHSAELQLSKINETLELLSESPVY 3636

Query: 396  -ISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
                  +  G   + IK+V+  D     V+ ++
Sbjct: 3637 PTKFDSEKEGTGPIFIKEVSNADISMGDVATLS 3669



 Score = 30.8 bits (68), Expect = 3.0
 Identities = 23/87 (26%), Positives = 37/87 (42%), Gaps = 14/87 (16%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT-----LLIKDVNKKD 417
             G  +++   +S  PPP + W  N           +L Q+ T   T     ++IK+  +  
Sbjct: 10234 GGVIRIIAYVSGKPPPTVTWNMNER---------TLPQEATIETTAISSSMVIKNCQRSH 10284

Query: 418   AGWYTVSAVNEAGVTTCNTRLDVTARP 444
              G Y++ A NEAG       +DV   P
Sbjct: 10285 QGVYSLLAKNEAGERKKTIIVDVLDVP 10311



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 24/105 (22%), Positives = 43/105 (40%), Gaps = 13/105 (12%)

Query: 274  SGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEAT 333
            +G P P  +W    + +++ D  KM  +      L+      SD G Y    +NR    +
Sbjct: 7114 TGYPRPTATWCFGDKVLETGDRVKM-KTLSAYAELVISPSERSDKGIYTLKLENRVKTIS 7172

Query: 334  FTVQLDVLAKEHKRAPMFIYKPQSKKVLE-GDSVKLECQISAIPP 377
              + ++V+A           +P + K L+ GD  K    ++  PP
Sbjct: 7173 GEIDVNVIA-----------RPSAPKELKFGDITKDSVHLTWEPP 7206



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 25/113 (22%), Positives = 45/113 (39%), Gaps = 5/113 (4%)

Query: 231   STSRGDVNDQDAIQ--EKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGR 288
             S S G +  +D I        P++  V   + +  G    ++  + G P PDV W  +G+
Sbjct: 18385 SDSSGAITARDEIDAPNASLDPKYKDV---IVVHAGETFVLEADIRGKPIPDVVWSKDGK 18441

Query: 289   TVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
              ++       I S     +L+ +    +D G Y     N  G  +  + + VL
Sbjct: 18442 ELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVL 18494



 Score = 30.0 bits (66), Expect = 5.1
 Identities = 25/96 (26%), Positives = 48/96 (50%), Gaps = 7/96 (7%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLL-IKDVNKKDAGWY 421
             G+ V++       PPP + W+++ + +  +  R S+  +NT   +LL I  V + D G Y
Sbjct: 20981 GEDVQVLIPFKGRPPPTVTWRKDEKNLGSDA-RYSI--ENTDSSSLLTIPQVTRNDTGKY 21037

Query: 422   TVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVR 457
              ++  N  G    +T   V+ +   T  A ++L+V+
Sbjct: 21038 ILTIENGVGEPKSST---VSVKVLDTPAACQKLQVK 21070



 Score = 30.0 bits (66), Expect = 5.1
 Identities = 16/61 (26%), Positives = 26/61 (42%), Gaps = 2/61 (3%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G +V LE      P P + W ++   +         +     ++TL IK+  K+  G YT
Sbjct: 21273 GHNVHLELPYKGKPKPSISWLKDG--LPLKESEFVRFSKTENKITLSIKNAKKEHGGKYT 21330

Query: 423   V 423
             V
Sbjct: 21331 V 21331



 Score = 29.6 bits (65), Expect = 6.6
 Identities = 24/102 (23%), Positives = 42/102 (41%), Gaps = 8/102 (7%)

Query: 244   QEKFYPPRFIQVPENMSIDEGRFC---RMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIV 300
             +++  PP      +   +   R C   R+   + G PAP+V W  +      + L K  +
Sbjct: 15547 EDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARD----HGESLDKASI 15602

Query: 301   SEKGLHS-LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
                  ++ LI   V   D+G Y    +N +G  +  V + VL
Sbjct: 15603 ESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVL 15644



 Score = 29.6 bits (65), Expect = 6.6
 Identities = 21/84 (25%), Positives = 36/84 (42%), Gaps = 3/84 (3%)

Query: 259   MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL-IFEVVRASD 317
             ++I  G    +D  V G P P + W    + +  D   K+ +   G  +  + +    SD
Sbjct: 22752 VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKEL--DLCEKVSLQYTGKRATAVIKFCDRSD 22809

Query: 318   AGAYACVAKNRAGEATFTVQLDVL 341
             +G Y    KN +G    +V + VL
Sbjct: 22810 SGKYTLTVKNASGTKAVSVMVKVL 22833



 Score = 29.3 bits (64), Expect = 8.7
 Identities = 18/86 (20%), Positives = 37/86 (43%), Gaps = 4/86 (4%)

Query: 360   VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
             V +G  ++L   I   P P   W +  + +     + ++   +     L+IK+ ++ D+G
Sbjct: 23843 VRQGGVIRLTIPIKGKPFPICKWTKEGQDIS----KRAMIATSETHTELVIKEADRGDSG 23898

Query: 420   WYTVSAVNEAGVTTCNTRLDVTARPN 445
              Y +   N+ G      ++ V   PN
Sbjct: 23899 TYDLVLENKCGKKAVYIKVRVIGSPN 23924


>gi|110349713 titin isoform novex-1 [Homo sapiens]
          Length = 27051

 Score =  127 bits (320), Expect = 2e-29
 Identities = 66/216 (30%), Positives = 115/216 (53%)

Query: 245  EKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG 304
            E+ Y P F+  P +    EG+  R D KV G P P+  W+ +G+ + +D  HK+++ E G
Sbjct: 1406 ERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDG 1465

Query: 305  LHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGD 364
              SLI      SD+G +  VA+NRAG ++ +V L V A EH+  PMF+ K ++  + EG 
Sbjct: 1466 TQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGS 1525

Query: 365  SVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVS 424
             ++++ + +  P P + W +N++++  +       +   G   L I     +D+ WYT +
Sbjct: 1526 RLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTAT 1585

Query: 425  AVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTF 460
            A+N+AG  T   +++V     +  P  K +  R T+
Sbjct: 1586 AINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTY 1621



 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 62/198 (31%), Positives = 92/198 (46%), Gaps = 7/198 (3%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIV--SEKGLH 306
             PP F     N +   G   R    ++  P P V+WY +G+ ++  D  K     S+KGL+
Sbjct: 25317 PPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLY 25376

Query: 307   SLIFEVVRASDAGAYACVAKNRAGE----ATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE 362
              L    V   D   Y  VA+N+ GE    A  TV L     +    PMF     + +  E
Sbjct: 25377 QLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQE 25436

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G SV  E ++S IPPP L W+++ + +    + I +  +      L I+D   +D G+Y 
Sbjct: 25437 GQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPN-IEIIHEGLDYYALHIRDTLPEDTGYYR 25495

Query: 423   VSAVNEAGVTTCNTRLDV 440
             V+A N AG T+C   L V
Sbjct: 25496 VTATNTAGSTSCQAHLQV 25513



 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 62/213 (29%), Positives = 109/213 (51%), Gaps = 13/213 (6%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVS-EKGLHSL 308
           P F Q  +++ + EG     +  +SG P P+VSW+ +G+ + +  L  + +S   G   L
Sbjct: 6   PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65

Query: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
               V  +++G Y+  A N +G+AT T +L  L K     P F+ + QS  V +G  V+L
Sbjct: 66  TIPAVTKANSGRYSLKATNGSGQATSTAEL--LVKAETAPPNFVQRLQSMTVRQGSQVRL 123

Query: 369 ECQISAIPPPKLFWKRNNEMVQFNTD-RISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
           + +++ IP P + + R+   +Q + D +IS   D     +LLI +   +D+G Y+V+A N
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGD---LYSLLIAEAYPEDSGTYSVNATN 180

Query: 428 EAGVTTCNTRL------DVTARPNQTLPAPKQL 454
             G  T    L      +V A+  +T+ +  Q+
Sbjct: 181 SVGRATSTAELLVQGEEEVPAKKTKTIVSTAQI 213



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 98/401 (24%), Positives = 166/401 (41%), Gaps = 59/401 (14%)

Query: 127  QPINAKPSQTAN-AKPIPRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQRLTYEEKM 185
            QP+  +  + A     I   P  +I   KE   Q L    KCK   LH+G +   Y   +
Sbjct: 3200 QPVTVQSGKPARFCAVISGRPQPKISWYKEE--QLLSTGFKCK--FLHDGQE---YTLLL 3252

Query: 186  ARRLLGPQNAAA-VFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQ 244
                  P++AA    +A++D G   +       A L V   +V S         DQ+   
Sbjct: 3253 IEAF--PEDAAVYTCEAKNDYGVATTS------ASLSVEVPEVVSP--------DQEM-- 3294

Query: 245  EKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG 304
               YPP  I   ++    EG+  R   +VSG     VSWY   + ++     +M   E  
Sbjct: 3295 -PVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLK-VSWYSKDKKIKPSRFFRMTQFEDT 3352

Query: 305  LHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDV------------------LAKEHK 346
                I E     D G Y  VA N  G+ + T  L +                  L+   K
Sbjct: 3353 YQLEIAEAY-PEDEGTYTFVASNAVGQVSSTANLSLEGFSKFEENTSNSQWHVSLSVSFK 3411

Query: 347  RAPM-----FIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQD 401
            + P+     FI    S +V  G++V+   ++S IP P++ W  N +++    D +  +++
Sbjct: 3412 KEPLGQKPSFIQPLSSLRVHNGETVRFHARVSGIPKPEIQWFHNQQLILPTKDVVFHFEE 3471

Query: 402  NTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPK-----QLRV 456
            +TG   +LI D   + AG Y+  A N AG  TC   L VT +  +++   +     ++ +
Sbjct: 3472 STGMALMLIVDAYSEHAGQYSCKAANSAGEATCAATLTVTPKAPESILHERIEQEIEMEM 3531

Query: 457  RPTFSKYLALNGKGL-NVKQAFNPEGEFQRLAAQSGLYESE 496
            +   S +L+   +GL + +   +   E   L ++S +Y ++
Sbjct: 3532 KEFSSSFLSAEEEGLHSAELQLSKINETLELLSESPVYPTK 3572



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 60/231 (25%), Positives = 94/231 (40%), Gaps = 42/231 (18%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP  +   +N+++ EG    ++  +SG P+P V+WY     ++S  +   I  + G+  L
Sbjct: 896  PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESS-IDFQITFQSGIARL 954

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDV----------------LAKEHKR----- 347
            +     A D+G + C A N AG  + +  L V                   E KR     
Sbjct: 955  MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESR 1014

Query: 348  --------------------APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNE 387
                                AP FI KP  +K++EG SV   CQ+   P P ++WK++  
Sbjct: 1015 DVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGV 1074

Query: 388  MVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 438
             +         Y   TG   L+I      DAG YT+   N+ G T+ +  L
Sbjct: 1075 PLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 55/182 (30%), Positives = 94/182 (51%), Gaps = 6/182 (3%)

Query: 259   MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDA 318
             MSI+EG+  R+  K +   A DV W LNG  + + + ++  VS     +L  +     D 
Sbjct: 26676 MSINEGQ--RLVLKANIAGATDVKWVLNGVELTNSEEYRYGVSGSD-QTLTIKQASHRDE 26732

Query: 319   GAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPP 378
             G   C++K + G       L  L+KE   AP FI +P+S+ + EG +V   C+IS  P P
Sbjct: 26733 GILTCISKTKEGIVKCQYDL-TLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSP 26791

Query: 379   KLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 438
             ++ W +NN  +  +++ +S+ + +    +L I++ +  D+G YT+ A N  G  +    L
Sbjct: 26792 EIEWFKNNLPISISSN-VSISR-SRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASL 26849

Query: 439   DV 440
              V
Sbjct: 26850 MV 26851



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 53/197 (26%), Positives = 83/197 (42%), Gaps = 2/197 (1%)

Query: 250   PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG-LHSL 308
             P F +   N+++       +  KV+G P P V WY  G+ + +D L   I   KG  H L
Sbjct: 24556 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQL 24615

Query: 309   IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
             I   V   DA  Y   A N+ G  + T  L+V        P  +    +   L G+ V +
Sbjct: 24616 IIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSI 24675

Query: 369   ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
             +   S  P P + W++  +++  N     +    +    +    V +KDAG+Y V A N 
Sbjct: 24676 KIPFSGKPDPVITWQKGQDLID-NNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNR 24734

Query: 429   AGVTTCNTRLDVTARPN 445
              G+      LDV   P+
Sbjct: 24735 FGIDQKTVELDVADVPD 24751



 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 53/229 (23%), Positives = 88/229 (38%), Gaps = 22/229 (9%)

Query: 250  PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
            P FI+   N  I  G    +   V G+P P + W+ NG  +     +K +      HSLI
Sbjct: 3582 PIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDD-HSLI 3640

Query: 310  FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK--EHKRA------------------P 349
                +  D G Y C+A N  G+   +  L + +K   HK                    P
Sbjct: 3641 ILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKLGGPCPP 3700

Query: 350  MFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLL 409
             F+ + +  +  +G     E  +   P P + W + N+ +  +     ++  N G  T +
Sbjct: 3701 HFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPN-GSGTFI 3759

Query: 410  IKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRP 458
            + D  ++D+G Y   A N  G +TC   L V          P + +  P
Sbjct: 3760 VNDPQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDTPCKAKSTP 3808



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 60/254 (23%), Positives = 116/254 (45%), Gaps = 21/254 (8%)

Query: 191  GPQNAAAVFQAQDDS--GAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFY 248
            G  +A    + QD+S   +++ ++ +SE    +V T +++    + G +  +D       
Sbjct: 4317 GVASAVVSDEKQDESLKPSEEKEESSSESGTEEVATVKIQE---AEGGLIKEDG------ 4367

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P     + + +S +EG    +   ++   A +V+WY   + V SD+  K +  ++  ++L
Sbjct: 4368 PMIHTPLVDTVS-EEGDIVHLTTSITN--AKEVNWYFENKLVPSDEKFKCL-QDQNTYTL 4423

Query: 309  IFEVVRASD-AGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
            + + V   D  G Y C A N +G+   + +L V+    + AP+   K +  +V  G   K
Sbjct: 4424 VIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVV---KRAAPVIKRKIEPLEVALGHLAK 4480

Query: 368  LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
              C+I + P  +  W +    + + +D+ S+ + +    +L I      D G YT  A N
Sbjct: 4481 FTCEIQSAPNVRFQWFKAGREI-YESDKCSI-RSSKYISSLEILRTQVVDCGEYTCKASN 4538

Query: 428  EAGVTTCNTRLDVT 441
            E G  +C   L VT
Sbjct: 4539 EYGSVSCTATLTVT 4552



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 39/126 (30%), Positives = 64/126 (50%), Gaps = 1/126 (0%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
           PP F+Q  ++M++ +G   R+  +V+G+P P V +Y +G  +QS  L   I  E  L+SL
Sbjct: 103 PPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQS-SLDFQISQEGDLYSL 161

Query: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
           +       D+G Y+  A N  G AT T +L V  +E   A        + ++ E    ++
Sbjct: 162 LIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRI 221

Query: 369 ECQISA 374
           E +I A
Sbjct: 222 EKKIEA 227



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 52/176 (29%), Positives = 78/176 (44%), Gaps = 16/176 (9%)

Query: 280  DVSWYLNGRTV--QSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQ 337
            D  WY +G  +  Q  + HK +V E+ +H +     R SDAG Y  V    AG    +V 
Sbjct: 3130 DAHWYKDGIEINFQVQERHKYVV-ERRIHRMFISETRQSDAGEYTFV----AGRNRSSVT 3184

Query: 338  LDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRIS 397
            L V A E    P  + + Q   V  G   +    IS  P PK+ W +  +++  +T    
Sbjct: 3185 LYVNAPE---PPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLL--STGFKC 3239

Query: 398  LYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV----TARPNQTLP 449
             +  +    TLL+ +   +DA  YT  A N+ GV T +  L V       P+Q +P
Sbjct: 3240 KFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMP 3295



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 50/209 (23%), Positives = 84/209 (40%), Gaps = 30/209 (14%)

Query: 281   VSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
             V+WY   R +++ + ++ I  E G+  L  + +   D G Y C   N  GE +   +L V
Sbjct: 25228 VTWYFGVRQLENSEKYE-ITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFV 25286

Query: 341   LAKEH-----------------------KRAPMFIYKPQSKKVLEGDSVKLECQISAIPP 377
                                         +R P F     +K    G++V+    I+  P 
Sbjct: 25287 KGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPE 25346

Query: 378   PKLFWKRNNEMVQ-FNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
             P + W ++ + ++  + D+   ++ + G   L I  V   D   YTV A N+ G  +C  
Sbjct: 25347 PHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKA 25406

Query: 437   RLDVTARPNQTLPAPKQLRVRPTFSKYLA 465
             +L VT       P P    +RP F + LA
Sbjct: 25407 KLTVTLH-----PPPTDSTLRPMFKRLLA 25430



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 48/200 (24%), Positives = 83/200 (41%), Gaps = 12/200 (6%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP+ +Q  + +++  G+  R    +SG P P +SWY   + + +    K +   +    L
Sbjct: 3192 PPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLL 3251

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKE--HKRAPMFIYKP------QSKKV 360
            + E     DA  Y C AKN  G AT +  L V   E       M +Y P      Q    
Sbjct: 3252 LIEAF-PEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVT 3310

Query: 361  LEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGW 420
             EG   + +C++S       ++ ++ ++      R++ ++D      L I +   +D G 
Sbjct: 3311 SEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDT---YQLEIAEAYPEDEGT 3367

Query: 421  YTVSAVNEAGVTTCNTRLDV 440
            YT  A N  G  +    L +
Sbjct: 3368 YTFVASNAVGQVSSTANLSL 3387



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 47/185 (25%), Positives = 87/185 (47%), Gaps = 8/185 (4%)

Query: 264   GRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYAC 323
             G   ++  ++ G P PD+ WY  G+ +     +KM  S+   H+L        D G Y C
Sbjct: 24175 GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKM-SSDGRTHTLTVMTEEQEDEGVYTC 24233

Query: 324   VAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWK 383
             +A N  GE   + +L +L    +  P +  K +    + G +++L       P P + W 
Sbjct: 24234 IATNEVGEVETSSKL-LLQATPQFHPGYPLKEKYYGAV-GSTLRLHVMYIGRPVPAMTWF 24291

Query: 384   RNNEMVQFNTDRISLYQDNTGRVT-LLIKDVNKK-DAGWYTVSAVNEAGVTTCNTRLDVT 441
                +++Q N++ I++  +NT   T L++K+V +K  AG Y V   N  G       +++ 
Sbjct: 24292 HGQKLLQ-NSENITI--ENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQ 24348

Query: 442   ARPNQ 446
              +P++
Sbjct: 24349 DKPDK 24353



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 36/117 (30%), Positives = 59/117 (50%), Gaps = 2/117 (1%)

Query: 324 VAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWK 383
           V   R  + T T ++    +     P  +   ++  V+EG+SV LEC IS  P P + W 
Sbjct: 872 VLHGREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWY 931

Query: 384 RNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
           R +  ++ + D    +Q    R  L+I++   +D+G +T SAVNEAG  + +  L V
Sbjct: 932 REDYQIESSIDFQITFQSGIAR--LMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV 986



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 62/264 (23%), Positives = 108/264 (40%), Gaps = 44/264 (16%)

Query: 235  GDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD 294
            GD+ D++  Q+ F+  +   +           CR+     G P   V W  +G+ +++ +
Sbjct: 1646 GDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLT--PIGDPTMVVEWLHDGKPLEAAN 1703

Query: 295  LHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAG----EATFTV-------------- 336
              +MI +E G  SL + V  + D+G   C A N+ G     AT  V              
Sbjct: 1704 RLRMI-NEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPE 1762

Query: 337  ---------QLDVLAKE-----------HKRAPMFIYKPQSKKVLEGDSVKLECQISAIP 376
                     +L+ +A E            K+ P  +  P+  +VLEG++ +  C+++  P
Sbjct: 1763 GRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYP 1822

Query: 377  PPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
             PK+ W  N ++++  + R  +  D  G   L I D    D G   V+A N  GV     
Sbjct: 1823 QPKVNWYLNGQLIR-KSKRFRVRYD--GIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKV 1879

Query: 437  RLDVTARPNQTLPAPKQLRVRPTF 460
            +L++  R +      +    RP F
Sbjct: 1880 KLEIQQREDFRSVLRRAPEPRPEF 1903



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 46/166 (27%), Positives = 79/166 (47%), Gaps = 13/166 (7%)

Query: 258  NMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASD 317
            N+ + E    ++  +VS  P  +V WY     +     ++ I++E     L+ +     D
Sbjct: 6099 NIEVSETDTIKLVCEVSK-PGAEVIWYKGDEEIIETGRYE-ILTEGRKRILVIQNAHLED 6156

Query: 318  AGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPP 377
            AG Y C   +         + D   K H+ A  FI KPQ+ ++LEG+  +  C IS    
Sbjct: 6157 AGNYNCRLPSS--------RTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESF 6208

Query: 378  PKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTV 423
            P + WKR+++ ++ + D+  +  D   RV L++KD   +D G Y V
Sbjct: 6209 P-VQWKRDDKTLE-SGDKYDVIADGKKRV-LVVKDATLQDMGTYVV 6251



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 1/125 (0%)

Query: 250   PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
             P FI  P + +I+EG+      ++SG P+P++ W+ N   + S   +  I   + ++SL 
Sbjct: 26762 PAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPI-SISSNVSISRSRNVYSLE 26820

Query: 310   FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLE 369
                   SD+G Y   AKN  G+ + T  L VL    + +   + +      L+G      
Sbjct: 26821 IRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQS 26880

Query: 370   CQISA 374
              Q+SA
Sbjct: 26881 VQMSA 26885



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 35/102 (34%), Positives = 50/102 (49%), Gaps = 3/102 (2%)

Query: 347 RAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV 406
           +AP F    QS  VLEG +   E  IS  P P++ W R+ +++  +T        + GR 
Sbjct: 4   QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63

Query: 407 TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV---TARPN 445
            L I  V K ++G Y++ A N +G  T    L V   TA PN
Sbjct: 64  KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPN 105



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 33/129 (25%), Positives = 63/129 (48%), Gaps = 8/129 (6%)

Query: 325  AKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSK----KVLEGDSVKLECQISAIPPPKL 380
            A N  GE+  ++ L+V+ ++ +  P    +   +    KV  G+ V +   ++ +P PK+
Sbjct: 8999 AVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKI 9058

Query: 381  FWKRNNEMVQFNTDRISLYQDNTGR----VTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
             W +N  +++  TD + + ++   R      L I    ++D G YTV+A N  G    N 
Sbjct: 9059 EWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNV 9118

Query: 437  RLDVTARPN 445
             ++V  RP+
Sbjct: 9119 HVEVYDRPS 9127



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 38/158 (24%), Positives = 66/158 (41%), Gaps = 4/158 (2%)

Query: 191  GPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPP 250
            G  + +A    +D+    +  Q       LQ    +   R    G +      Q++   P
Sbjct: 1738 GTDHTSATLIVKDEKSLVEESQLPEGRKGLQ--RIEELERMAHEGALTGVTTDQKEKQKP 1795

Query: 251  RFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
              +  PE + + EG   R   +V+G P P V+WYLNG+ ++     +  V   G+H L  
Sbjct: 1796 DIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKS--KRFRVRYDGIHYLDI 1853

Query: 311  EVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRA 348
               ++ D G     A+N  G     V+L++  +E  R+
Sbjct: 1854 VDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRS 1891



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 43/153 (28%), Positives = 68/153 (44%), Gaps = 11/153 (7%)

Query: 301  SEKGLHSLIFEVVRASDAGAYACVAK--NRAGEATFTVQLDVLAKEHKRAPMFIYKPQSK 358
            +++ +  L F V    + G Y    K  N AG +  +  +     +    P  I   +  
Sbjct: 9695 NKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFM 9754

Query: 359  KVLEGDSVKLECQISAIPPPKLFWKR-------NNEMVQFNTDRISLYQDNTGRVTLLIK 411
            +V EG +V +  +I  +P P L W +       N E V ++T    L  D+T   TL+I 
Sbjct: 9755 EVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDT--CTLVIP 9812

Query: 412  DVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARP 444
               + D G YT++AVN  G  +   RL+V  RP
Sbjct: 9813 QSRRSDTGLYTITAVNNLGTASKEMRLNVLGRP 9845



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 48/162 (29%), Positives = 72/162 (44%), Gaps = 11/162 (6%)

Query: 277  PAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTV 336
            P   V WY +G  V   D ++M  S++ +H L    +  SDA  Y+CV        T T 
Sbjct: 2155 PFVKVKWYKDGMEVHEGDKYRMH-SDRKVHFLSILTIDTSDAEDYSCVLVEDENVKT-TA 2212

Query: 337  QLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRI 396
            +L V          F+ + Q  +V E  S +LEC +S   P  +  K  +  V+  ++  
Sbjct: 2213 KLIV----EGAVVEFVKELQDIEVPESYSGELECIVS---PENIEGKWYHNDVELKSNGK 2265

Query: 397  SLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 438
                   GR  L +KDV K+D G Y  S V +   TTC  ++
Sbjct: 2266 YTITSRRGRQNLTVKDVTKEDQGEY--SFVIDGKKTTCKLKM 2305



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 40/147 (27%), Positives = 71/147 (48%), Gaps = 3/147 (2%)

Query: 299   IVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQ-LDVLAKEHKRAPMFIYKPQS 357
             IV+E  + + +   + +     +   A N  G++   V  + V+AK+    P       +
Sbjct: 17889 IVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNT 17948

Query: 358   KKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKD 417
               +  G+ +K+E  +   P P + W ++ E ++  T R+++ +  T  V L IK+ NK D
Sbjct: 17949 YSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLK-QTTRVNVEETATSTV-LHIKEGNKDD 18006

Query: 418   AGWYTVSAVNEAGVTTCNTRLDVTARP 444
              G YTV+A N AG  T N  + V  +P
Sbjct: 18007 FGKYTVTATNSAGTATENLSVIVLEKP 18033



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 32/143 (22%), Positives = 67/143 (46%), Gaps = 2/143 (1%)

Query: 307   SLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSV 366
             SL+   ++      +   A+N  G +       V   + +  P  I  P+   +  G  +
Sbjct: 12485 SLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKL 12544

Query: 367   KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAV 426
             ++E  +   P P   WK+  + V   +  +++++ ++  + L+IKDV +KD+G+Y+++A 
Sbjct: 12545 RIEAHVYGKPHPTCKWKKGEDEV-VTSSHLAVHKADSSSI-LIIKDVTRKDSGYYSLTAE 12602

Query: 427   NEAGVTTCNTRLDVTARPNQTLP 449
             N +G  T   ++ V   P    P
Sbjct: 12603 NSSGTDTQKIKVVVMDAPGPPQP 12625



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 33/153 (21%), Positives = 65/153 (42%), Gaps = 6/153 (3%)

Query: 198  VFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFY------PPR 251
            +F   +D G       N     +     ++ S+     D   + A+ +         PP 
Sbjct: 3642 LFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKLGGPCPPH 3701

Query: 252  FIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFE 311
            F++  + +   +G     ++ V G PAP V+W+   + + +   + +I +  G  + I  
Sbjct: 3702 FLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNGSGTFIVN 3761

Query: 312  VVRASDAGAYACVAKNRAGEATFTVQLDVLAKE 344
              +  D+G Y C A+N  GE+T   +L VL ++
Sbjct: 3762 DPQREDSGLYICKAENMLGESTCAAELLVLLED 3794



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 28/93 (30%), Positives = 46/93 (49%), Gaps = 1/93 (1%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKM-IVSEKGLHS 307
             PP+   +P ++SIDEG+   +    +G P P+V+W   GR + S +  +  I +   L +
Sbjct: 26956 PPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTT 27015

Query: 308   LIFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
             LI   V+  D G Y     N  G  + TV + +
Sbjct: 27016 LIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 27048



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 34/117 (29%), Positives = 55/117 (47%), Gaps = 5/117 (4%)

Query: 236  DVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDL 295
            D+++ +A++  F   R     +N  I EG       K+SG P P ++WY +G+ ++  + 
Sbjct: 1236 DISESEAVESGF-DSRI----KNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGER 1290

Query: 296  HKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFI 352
            ++M   + G  SL   VV   D G Y   A N  G A  + +L V       AP +I
Sbjct: 1291 YQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYI 1347



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 48/189 (25%), Positives = 83/189 (43%), Gaps = 14/189 (7%)

Query: 244  QEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVS---WYLNGRTVQSDDLHKMIV 300
            Q K  P +F++  +++ + E  F         L +P  +   W  +G  ++    H+ I 
Sbjct: 4737 QLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSPSTAITTWMKDGSNIRESPKHRFIA 4796

Query: 301  SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKK- 359
              K     I +V + SDAG Y CV +    E T T +L V     +  P+   K   ++ 
Sbjct: 4797 DGKDRKLHIIDV-QLSDAGEYTCVLRLGNKEKTSTAKLVV-----EELPVRFVKTLEEEV 4850

Query: 360  -VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
             V++G  + L C+++      + W+++ ++V     RI        R  L I D +  DA
Sbjct: 4851 TVVKGQPLYLSCELN--KERDVVWRKDGKIVVEKPGRIVPGVIGLMR-ALTINDADDTDA 4907

Query: 419  GWYTVSAVN 427
            G YTV+  N
Sbjct: 4908 GTYTVTVEN 4916



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 48/179 (26%), Positives = 73/179 (40%), Gaps = 14/179 (7%)

Query: 252  FIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFE 311
            FI  P+N+ I EG        +S    P V W  + +T++S D + +I   K    L+ +
Sbjct: 6182 FISKPQNLEILEGEKAEFVCSISKESFP-VQWKRDDKTLESGDKYDVIADGKK-RVLVVK 6239

Query: 312  VVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQ 371
                 D G Y  +     G A     L V+ K     P+     +  +V E   V   C+
Sbjct: 6240 DATLQDMGTYVVMV----GAARAAAHLTVIEKLRIVVPL-----KDTRVKEQQEVVFNCE 6290

Query: 372  ISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
            ++     K  W RN E +  ++  I L +D     TL I+D +  D   Y VS  N  G
Sbjct: 6291 VNT-EGAKAKWFRNEEAIFDSSKYIILQKDLV--YTLRIRDAHLDDQANYNVSLTNHRG 6346



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 34/133 (25%), Positives = 64/133 (48%), Gaps = 10/133 (7%)

Query: 251   RFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
             R +  P +M++ EG   R      G P P V+W   G+ + +   H++  ++   +   F
Sbjct: 26190 RILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTK---YKSTF 26246

Query: 311   EV--VRASDAGAYACVAKNRAG----EATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGD 364
             E+  V+ASD G Y+ V +N  G    E T T+Q   + ++   +P  +  P+  +V   +
Sbjct: 26247 EISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPE-PRVKSPE 26305

Query: 365   SVKLECQISAIPP 377
             +VK   ++ +  P
Sbjct: 26306 AVKSPKRVKSPEP 26318



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 45/200 (22%), Positives = 85/200 (42%), Gaps = 17/200 (8%)

Query: 256   PENMSI-DEGR------FCRMDFKVSGLPAPDVSWYLNGRTVQSDD---LHKMIVSEKGL 305
             PEN+ I D+G+      + R D+      +P++S+++  R   SDD   +HK  + E   
Sbjct: 11732 PENLHIADKGKTFVYLKWRRPDYDGG---SPNLSYHVERRLKGSDDWERVHKGSIKET-- 11786

Query: 306   HSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE-GD 364
             H ++   V  +    +    KN  GE+ +    +V+ KE  + P+   K      ++ GD
Sbjct: 11787 HYMVDRCVE-NQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGD 11845

Query: 365   SVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVS 424
             +++LE  +   P P++ W ++ +                      +    + D G Y V+
Sbjct: 11846 TIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVT 11905

Query: 425   AVNEAGVTTCNTRLDVTARP 444
             A N AG       ++V  +P
Sbjct: 11906 ATNTAGSFVAYATVNVLDKP 11925



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 50/182 (27%), Positives = 83/182 (45%), Gaps = 21/182 (11%)

Query: 257  ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG-LHSLIFEVVRA 315
            +++++  G     D ++S    P V WYL G+ ++  D  K++   +G +H+L    V+ 
Sbjct: 5831 KDVTVTAGETATFDCELSYEDIP-VEWYLKGKKLEPSD--KVVPRSEGKVHTLTLRDVKL 5887

Query: 316  SDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKP-QSKKVLEGDSVKLECQISA 374
             DAG     AK+    A   V         K  P+   KP + + V EG +  LEC++S 
Sbjct: 5888 EDAGEVQLTAKDFKTHANLFV---------KEPPVEFTKPLEDQTVEEGATAVLECEVSR 5938

Query: 375  IPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV-TLLIKDVNKKDAGWYTVSAVNEAGVTT 433
                K+ W +N   +   + +  +  D  GRV  L+I D   +D   YT  A +    T+
Sbjct: 5939 -ENAKVKWFKNGTEI-LKSKKYEIVAD--GRVRKLVIHDCTPEDIKTYTCDAKDFK--TS 5992

Query: 434  CN 435
            CN
Sbjct: 5993 CN 5994



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 33/111 (29%), Positives = 55/111 (49%), Gaps = 8/111 (7%)

Query: 235   GDVNDQDAIQEKFYPPRF---IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTV- 290
             G+V D   ++++   P       V + + +  G   R+   VSG P P V+W +N RT+ 
Sbjct: 10135 GEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLP 10194

Query: 291   QSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
             Q   +    +S     S++ +  + S  G Y+ +AKN AGE   T+ +DVL
Sbjct: 10195 QEATIETTAISS----SMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVL 10241



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 62/269 (23%), Positives = 101/269 (37%), Gaps = 46/269 (17%)

Query: 166  KCKDTLLHNGNQRLTYEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTS 225
            K KD LLH   + LT EEK A                            +E  ++ +PT 
Sbjct: 1987 KTKDELLH-WTKELTEEEKKAL---------------------------AEEGKITIPTF 2018

Query: 226  QVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYL 285
            +            D+  +      P+  +  ++ ++ +G       +V G P P+  WY 
Sbjct: 2019 KP-----------DKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYK 2067

Query: 286  NGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEH 345
            NG  ++  D       E  +  L+   V A D+ +    A N AGE +    L V AK+ 
Sbjct: 2068 NGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQ- 2126

Query: 346  KRAPMFIYKPQSKKVLEGDSV-KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTG 404
                 F  + Q     E D++   EC+ S  P  K+ W ++  M     D+  ++ D   
Sbjct: 2127 --LITFTQELQDVVAKEKDTMATFECETSE-PFVKVKWYKDG-MEVHEGDKYRMHSDRKV 2182

Query: 405  RVTLLIKDVNKKDAGWYTVSAVNEAGVTT 433
               L I  ++  DA  Y+   V +  V T
Sbjct: 2183 HF-LSILTIDTSDAEDYSCVLVEDENVKT 2210



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 32/114 (28%), Positives = 56/114 (49%), Gaps = 3/114 (2%)

Query: 359  KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
            ++LEG  V   C++S  P PK+ W ++ + ++ + +R  +     GR +L I  V  +D 
Sbjct: 1255 RILEGMGVTFHCKMSGYPLPKIAWYKDGKRIK-HGERYQMDFLQDGRASLRIPVVLPEDE 1313

Query: 419  GWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLN 472
            G YT  A N  G   C+ +L V   P   L AP  +      S+  +L+ + ++
Sbjct: 1314 GIYTAFASNIKGNAICSGKLYV--EPAAPLGAPTYIPTLEPVSRIRSLSPRSVS 1365



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 30/82 (36%), Positives = 42/82 (51%), Gaps = 2/82 (2%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G    ++  IS  P PK+ WK   EM    TDR+S+      R TL +KD  + D+G Y 
Sbjct: 22290 GSPFTIDVPISGRPAPKVTWKLE-EMRLKETDRVSI-TTTKDRTTLTVKDSMRGDSGRYF 22347

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             ++  N AGV T +  + V  RP
Sbjct: 22348 LTLENTAGVKTFSVTVVVIGRP 22369



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 42/141 (29%), Positives = 74/141 (52%), Gaps = 14/141 (9%)

Query: 283  WYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLA 342
            WY N   ++S+  +  I S +G  +L  + V   D G Y+ V   +  + T  +++    
Sbjct: 2253 WYHNDVELKSNGKYT-ITSRRGRQNLTVKDVTKEDQGEYSFVIDGK--KTTCKLKM---- 2305

Query: 343  KEHKRAPMFIYKPQS-KKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQD 401
               K  P+ I +  S +KV EGD V+LE ++S +   +  W ++ + VQ  +DR+ +  D
Sbjct: 2306 ---KPRPIAILQGLSDQKVCEGDIVQLEVKVS-LESVEGVWMKDGQEVQ-PSDRVHIVID 2360

Query: 402  NTGRVTLLIKDVNKKDAGWYT 422
                + LLI+D+ K+DAG Y+
Sbjct: 2361 KQSHM-LLIEDMTKEDAGNYS 2380



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 41/178 (23%), Positives = 79/178 (44%), Gaps = 15/178 (8%)

Query: 251  RFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
            + I+ P++++  E      +  VS    P V W+     ++  D H++ VSE+ +H L+ 
Sbjct: 2750 KIIKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKSVEIKPSDKHRL-VSERKVHKLML 2807

Query: 311  EVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLEC 370
            + +  SDAG Y  V      +A   V+   + K  K     I  P++K      +   EC
Sbjct: 2808 QNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKN----IEVPETK------TASFEC 2857

Query: 371  QISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            ++S    P + W +N   ++ +     + Q    +  L+I + + +D+  YT    N+
Sbjct: 2858 EVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQ--LIIMNTSTEDSAEYTFVCGND 2912



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 40/148 (27%), Positives = 68/148 (45%), Gaps = 12/148 (8%)

Query: 225   SQVRSRSTSRGDVN--------DQDAIQEKFYPPRF---IQVPENMSIDEGRFCRMDFKV 273
             +Q + R+ +R  VN        D   I  +  PPR    + +   +++  G    +D  V
Sbjct: 12888 AQYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATV 12947

Query: 274   SGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEAT 333
              G P P VSW  +G  ++  +  KM + ++ L +L    V   D+G Y   A+N +G  +
Sbjct: 12948 FGKPMPTVSWKKDGTLLKPAEGIKMAM-QRNLCTLELFSVNRKDSGDYTITAENSSGSKS 13006

Query: 334   FTVQLDVLAKEHKRAPMFIYKPQSKKVL 361
              T++L VL K    A + I K  S + +
Sbjct: 13007 ATIKLKVLDKPGPPASVKINKMYSDRAM 13034



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 34/123 (27%), Positives = 59/123 (47%), Gaps = 6/123 (4%)

Query: 325   AKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAIPPPKLF 381
             A+N  GE T + ++ V+A++   AP    K          E  + +L+  I   P P + 
Sbjct: 13585 AENENGEGTPS-EITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVS 13643

Query: 382   WKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVT 441
             WK+  + +  +T R+S+ + +    TL++ D  K DAG YT++  N AG       + V 
Sbjct: 13644 WKKGEDPLATDT-RVSV-ESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVV 13701

Query: 442   ARP 444
              +P
Sbjct: 13702 GKP 13704



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 49/180 (27%), Positives = 84/180 (46%), Gaps = 25/180 (13%)

Query: 250  PRFIQVPENMS---IDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQ-SDDLHKMIVSEKGL 305
            PR I + + +S   + EG   +++ KVS L + +  W  +G+ VQ SD +H  IV +K  
Sbjct: 2307 PRPIAILQGLSDQKVCEGDIVQLEVKVS-LESVEGVWMKDGQEVQPSDRVH--IVIDKQS 2363

Query: 306  HSLIFEVVRASDAGAYA----CVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL 361
            H L+ E +   DAG Y+     +  + +G  +    +DV+       P+     +   V+
Sbjct: 2364 HMLLIEDMTKEDAGNYSFTIPALGLSTSGRVS-VYSVDVIT------PL-----KDVNVI 2411

Query: 362  EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWY 421
            EG    LEC++S      + W  N+E ++   DR+      T +  L+I   +  D G Y
Sbjct: 2412 EGTKAVLECKVSVPDVTSVKWYLNDEQIK-PDDRVQAIVKGT-KQRLVINRTHASDEGPY 2469



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 28/96 (29%), Positives = 46/96 (47%), Gaps = 1/96 (1%)

Query: 348  APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
            AP    + QS+ V +G       ++   P P+  W +N   ++  +DRI  Y        
Sbjct: 2031 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIE-RSDRIYWYWPEDNVCE 2089

Query: 408  LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTAR 443
            L+I+DV  +D+    V A+N AG T+ +  L V A+
Sbjct: 2090 LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAK 2125



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 41/174 (23%), Positives = 71/174 (40%), Gaps = 19/174 (10%)

Query: 263  EGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYA 322
            EG    +      +P P VSW+ +G+ V++ D   M       H  + + VRA DAG Y 
Sbjct: 8028 EGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRA-DAGIYT 8086

Query: 323  CVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPP----- 377
               +N+ G AT ++ + V+                K +   D  K  C+++  PP     
Sbjct: 8087 ITLENKLGSATASINVKVIG----------LPGPCKDIKASDITKSSCKLTWEPPEFDGG 8136

Query: 378  -PKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
             P L +          T    +  +N  +++  +KD+      ++ V AVN+ G
Sbjct: 8137 TPILHYVLERREAGRRTYIPVMSGEN--KLSWTVKDLIPNGEYFFRVKAVNKVG 8188



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 24/86 (27%), Positives = 45/86 (52%), Gaps = 2/86 (2%)

Query: 359   KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
             K   G SVKL   IS  P P + W ++++ +Q  T+ +   ++ T   ++LIKD ++ ++
Sbjct: 20511 KYRAGTSVKLRAGISGKPAPTIEWYKDDKELQ--TNALVCVENTTDLASILIKDADRLNS 20568

Query: 419   GWYTVSAVNEAGVTTCNTRLDVTARP 444
             G Y +   N  G  +   R+ +  +P
Sbjct: 20569 GCYELKLRNAMGSASATIRVQILDKP 20594



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 52/193 (26%), Positives = 79/193 (40%), Gaps = 18/193 (9%)

Query: 251  RFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
            +F+   E+ ++ EG       ++S      V W+ N   + +     +I SE   H L  
Sbjct: 5203 KFMSPLEDQTVKEGETATFVCELSH-EKMHVVWFKNDAKLHTSRT-VLISSEGKTHKLEM 5260

Query: 311  EVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLEC 370
            + V   D        K    E + T QL VL  +    P F  K   K  +E D + L+C
Sbjct: 5261 KEVTLDDISQIKAQVK----ELSSTAQLKVLEAD----PYFTVKLHDKTAVEKDEITLKC 5312

Query: 371  QISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
            ++S   P K F K   E+V   + + S+  D   R+ L IK  + KD G Y    V + G
Sbjct: 5313 EVSKDVPVKWF-KDGEEIVP--SPKYSIKADGLRRI-LKIKKADLKDKGEY----VCDCG 5364

Query: 431  VTTCNTRLDVTAR 443
                   + V AR
Sbjct: 5365 TDKTKANVTVEAR 5377



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 27/101 (26%), Positives = 43/101 (42%), Gaps = 4/101 (3%)

Query: 244   QEKFYPPRF---IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIV 300
             QEK  PP     +++ E + +  G   R    + G+P P   W  +G  +++D+ H  + 
Sbjct: 11130 QEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDE-HYTVE 11188

Query: 301   SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
             ++     L  +     D G Y     N AG  T  V L VL
Sbjct: 11189 TDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVL 11229



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 36/144 (25%), Positives = 67/144 (46%), Gaps = 4/144 (2%)

Query: 303   KGLHSLIFEVVRASDAGAYACVAKNRAGEAT-FTVQLDVLAKEHKRAPMFIYKPQSKKVL 361
             K L ++I  + +  +   +  VA N  G +   ++ + ++AK+    P       S  V 
Sbjct: 16812 KSLQAVITNLTQGEEY-LFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQ 16870

Query: 362   EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWY 421
              G  +K+E  IS  P P + W ++   ++  T RI++  D+    TL IK+ +K D G Y
Sbjct: 16871 VGQDLKIEVPISGRPKPTITWTKDGLPLK-QTTRINV-TDSLDLTTLSIKETHKDDGGQY 16928

Query: 422   TVSAVNEAGVTTCNTRLDVTARPN 445
              ++  N  G  T +  +    +P+
Sbjct: 16929 GITVANVVGQKTASIEIVTLDKPD 16952



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 27/106 (25%), Positives = 53/106 (50%), Gaps = 2/106 (1%)

Query: 339  DVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISL 398
            +V+AK+    P    +     V+EG+ + +     A+P P + W ++ + V+  +DR+++
Sbjct: 8005 NVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVK-ASDRLTM 8063

Query: 399  YQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARP 444
              D+      + K V + DAG YT++  N+ G  T +  + V   P
Sbjct: 8064 KNDHISAHLEVPKSV-RADAGIYTITLENKLGSATASINVKVIGLP 8108



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 44/180 (24%), Positives = 77/180 (42%), Gaps = 19/180 (10%)

Query: 321   YACVAKNRAGEATFTVQLD----VLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQIS 373
             +  +A+N AG   F+   D    + A++   AP     P+ K V+    G++  LE  I 
Sbjct: 18303 FRVIARNAAGN--FSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIR 18360

Query: 374   AIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTT 433
               P P + W ++ + ++    R+ + +    + TL++KD  + D G Y +   N  G  +
Sbjct: 18361 GKPIPDVVWSKDGKELEETAARMEI-KSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKS 18419

Query: 434   CNTRLDVTARPNQTLPAPKQLRVRPTFSK--YLA----LNGKGLNVKQAFNPEGEFQRLA 487
                 + V  RP    P    L+V    ++  YLA    L   G N+      + E  RL+
Sbjct: 18420 IPITVKVLDRPG---PPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLS 18476



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 51/200 (25%), Positives = 85/200 (42%), Gaps = 25/200 (12%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P  F++  E+ ++ E        ++S   A +V WY NGR ++    +K    +  +H L
Sbjct: 6450 PTEFVEHLEDQTVTEFDDAVFSCQLSREKA-NVKWYRNGREIKEGKKYKF-EKDGSIHRL 6507

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL---EGDS 365
            I +  R  D   YAC  ++R   A   V  + +  E  R P  I +     V+   E + 
Sbjct: 6508 IIKDCRLDDECEYACGVEDRKSRARLFV--EEIPVEIIRPPQDILEAPGADVVFLAELNK 6565

Query: 366  VKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV-TLLIKDVNKKDAGWYTVS 424
             K+E Q          W RNN MV    D+  +  +  G++  L I D+  +D G Y   
Sbjct: 6566 DKVEVQ----------WLRNN-MVVVQGDKHQMMSE--GKIHRLQICDIKPRDQGEYRFI 6612

Query: 425  AVNEAGVTTCNTRLDVTARP 444
            A ++        +L++ A P
Sbjct: 6613 AKDK----EARAKLELAAAP 6628



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 32/135 (23%), Positives = 64/135 (47%), Gaps = 6/135 (4%)

Query: 299   IVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSK 358
             I + KGL  ++  +    +   +  +A N AG +       V+ KE    P    +   +
Sbjct: 14642 ITTVKGLECVVRNLTEGEEY-TFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQ 14700

Query: 359   KVL---EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNK 415
             K++    GD++K+E  +   P P + WK+ +++++  T R++     T  + L I +  +
Sbjct: 14701 KLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILK-QTQRVNFETTATSTI-LNINECVR 14758

Query: 416   KDAGWYTVSAVNEAG 430
              D+G Y ++A N  G
Sbjct: 14759 SDSGPYPLTARNIVG 14773



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 29/102 (28%), Positives = 50/102 (49%), Gaps = 10/102 (9%)

Query: 250  PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYL-------NGRTVQSD-DLHKMIVS 301
            P  I + E M ++EG    +  K+ G+P P ++W+        N   V  D  ++K++V 
Sbjct: 9745 PPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVD 9804

Query: 302  EKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
            +    +L+    R SD G Y   A N  G A+  ++L+VL +
Sbjct: 9805 D--TCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGR 9844



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 34/128 (26%), Positives = 56/128 (43%), Gaps = 8/128 (6%)

Query: 325  AKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSK---KVLEGDSVKLECQISAIPPPKLF 381
            A N AGE        V   E +  P        K   +++ G ++++   ++  P P   
Sbjct: 8706 AVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKV 8765

Query: 382  WKRNNEMVQFNTDRISLYQDNTG-RVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
            W +  E  + + DR+ +  DN G +  L+IKD  +KD G Y ++A N  G      R++V
Sbjct: 8766 WTK--EEGELDKDRVVI--DNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEV 8821

Query: 441  TARPNQTL 448
               P   L
Sbjct: 8822 FDVPGPVL 8829



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 52/193 (26%), Positives = 78/193 (40%), Gaps = 23/193 (11%)

Query: 277   PAPDVSWYLNGRTVQSDDLHK---MIVSEKGLHSLIFEVVRASDAGAYA--CVAKNRAG- 330
             P  D    L G  V+  DL     M  +   +    F V    + G Y     AKN AG 
Sbjct: 13925 PKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGA 13984

Query: 331   -----EATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE---GDSVKLEC-QISAIPPPKLF 381
                  E+T T+    + K+   AP  +  P  K  L    GD++ L    I   P PK  
Sbjct: 13985 ISAPSESTETI----ICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSS 14040

Query: 382   WKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVT 441
             W +  + ++  +D   +    T  + L IK   +KDAG YT++A N  G    + ++ V 
Sbjct: 14041 WSKAGKDIR-PSDITQITSTPTSSM-LTIKYATRKDAGEYTITATNPFGTKVEHVKVTVL 14098

Query: 442   ARPNQTLPAPKQL 454
               P    P P ++
Sbjct: 14099 DVPGP--PGPVEI 14109



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 28/99 (28%), Positives = 46/99 (46%), Gaps = 2/99 (2%)

Query: 243   IQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSE 302
             +  K + P+ ++    +    G    +    SG P P ++W   G+ +  ++ H  ++  
Sbjct: 24649 VPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQ-KGQDLIDNNGHYQVIVT 24707

Query: 303   KGLHSLIF-EVVRASDAGAYACVAKNRAGEATFTVQLDV 340
             +   SL+F   V   DAG Y   AKNR G    TV+LDV
Sbjct: 24708 RSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDV 24746



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 40/169 (23%), Positives = 63/169 (37%), Gaps = 8/169 (4%)

Query: 178  RLTYEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDV 237
            R  + E   R      N A           Q S++   E   +    +    R     DV
Sbjct: 957  REAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDV 1016

Query: 238  --NDQDAIQEKFYP-----PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTV 290
               D    +E+  P     P FI  P    + EG       +V G P P V W  +G  +
Sbjct: 1017 VMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPL 1076

Query: 291  QSDDLHKMIVSEK-GLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQL 338
             +   +K+  +++ G   L+  +  A DAG Y  V +N+ GE + +  L
Sbjct: 1077 TTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 28/108 (25%), Positives = 48/108 (44%), Gaps = 2/108 (1%)

Query: 244   QEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEK 303
             +E+  PP+ + +PE ++I  G+  R++  V G P P   W   G        H  +    
Sbjct: 12522 KEQLLPPKIL-MPEQITIKAGKKLRIEAHVYGKPHPTCKW-KKGEDEVVTSSHLAVHKAD 12579

Query: 304   GLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMF 351
                 LI + V   D+G Y+  A+N +G  T  +++ V+       P F
Sbjct: 12580 SSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPF 12627



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 27/102 (26%), Positives = 49/102 (48%), Gaps = 6/102 (5%)

Query: 360   VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
             V  G +V L+  +   P P + WK++  +++         Q N    TL +  VN+KD+G
Sbjct: 12935 VKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNL--CTLELFSVNRKDSG 12992

Query: 420   WYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFS 461
              YT++A N +G  +   +L V  +P      P  +++   +S
Sbjct: 12993 DYTITAENSSGSKSATIKLKVLDKPG----PPASVKINKMYS 13030



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 39/150 (26%), Positives = 63/150 (42%), Gaps = 17/150 (11%)

Query: 231   STSRGDVNDQDAIQEKFYPPRFIQVP---ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNG 287
             S S G +  +D +     PPR    P   + + +  G   ++D  + G P P + W + G
Sbjct: 16154 SESTGAITARDEVD----PPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQW-IKG 16208

Query: 288   RTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKR 347
                 S+     I S     SL  +     D+G Y   AKN AGE + TV + VL +    
Sbjct: 16209 DQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPG-- 16266

Query: 348   APMFIYKPQSKKVLEGDSVKLECQISAIPP 377
                    P+   V+ G + + +C ++  PP
Sbjct: 16267 ------PPEGPVVISGVTAE-KCTLAWKPP 16289



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 21/86 (24%), Positives = 36/86 (41%)

Query: 355   PQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVN 414
             P    + EG  + + C  +  P P++ W      +          ++     TL+I DV 
Sbjct: 26963 PSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQ 27022

Query: 415   KKDAGWYTVSAVNEAGVTTCNTRLDV 440
             K+D G YT+S  NE G  +    + +
Sbjct: 27023 KQDGGLYTLSLGNEFGSDSATVNIHI 27048



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 42/204 (20%), Positives = 72/204 (35%), Gaps = 37/204 (18%)

Query: 274   SGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAG--- 330
             S L A +V+WY +G+ ++ +   +   S  G + L    +  SD G Y C      G   
Sbjct: 26370 SVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSK 26429

Query: 331   -------------------------------EATFTVQLDVLAKEH-KRAPMFIYKPQSK 358
                                            E+T T + +  A E     P+ +   Q  
Sbjct: 26430 TNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDT 26489

Query: 359   KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
              V      K   + +  P P   W ++ + +     +  L +D  G   L I   +  D+
Sbjct: 26490 TVSSDSVAKFAVKATGEPRPTAIWTKDGKAIT-QGGKYKLSEDK-GGFFLEIHKTDTSDS 26547

Query: 419   GWYTVSAVNEAGVTTCNTRLDVTA 442
             G YT +  N AG  + + +L + A
Sbjct: 26548 GLYTCTVKNSAGSVSSSCKLTIKA 26571



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 30/129 (23%), Positives = 60/129 (46%), Gaps = 7/129 (5%)

Query: 321   YACVAKNRAGEATFTVQLD--VLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAI 375
             +  +AKN AG  +   +    +  ++   AP      + K  +    G++ +LE  +S  
Sbjct: 15057 FRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGR 15116

Query: 376   PPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCN 435
             PPP + W ++ + ++  T ++ +   +     L+ KD  ++D+G YT++A N  G     
Sbjct: 15117 PPPTMEWSKDGKELE-GTAKLEIKIADFS-TNLVNKDSTRRDSGAYTLTATNPGGFAKHI 15174

Query: 436   TRLDVTARP 444
               + V  RP
Sbjct: 15175 FNVKVLDRP 15183



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 26/95 (27%), Positives = 45/95 (47%), Gaps = 2/95 (2%)

Query: 336   VQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDR 395
             + + V+AK+    P F     +  VL G+ +K++      P P + W ++N  ++  T R
Sbjct: 15763 LSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLK-QTTR 15821

Query: 396   ISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
             ++  +       L IKD  ++D G Y V   N AG
Sbjct: 15822 VNA-ESTENNSLLTIKDACREDVGHYVVKLTNSAG 15855



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 21/86 (24%), Positives = 38/86 (44%), Gaps = 1/86 (1%)

Query: 257   ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRAS 316
             ++ ++      +   K +G P P   W  +G+ +     +K+   +KG   L       S
Sbjct: 26487 QDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLS-EDKGGFFLEIHKTDTS 26545

Query: 317   DAGAYACVAKNRAGEATFTVQLDVLA 342
             D+G Y C  KN AG  + + +L + A
Sbjct: 26546 DSGLYTCTVKNSAGSVSSSCKLTIKA 26571



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 39/163 (23%), Positives = 66/163 (40%), Gaps = 16/163 (9%)

Query: 281  VSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
            V W+ N + + +     M   E   HS+ F+ +   D       A   + EA  TV    
Sbjct: 5587 VKWFKNDQRLHTTRSVSM-QDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVL--- 5642

Query: 341  LAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQ 400
                 +  P F  K Q    +E D V L+C+IS    P  ++K   E+      + ++ +
Sbjct: 5643 -----EGDPYFTGKLQDYTGVEKDEVILQCEISKADAPVKWFKDGKEI---KPSKNAVIK 5694

Query: 401  DNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTAR 443
             +  +  L++K   K D G YT     + G    + +LD+  R
Sbjct: 5695 ADGKKRMLILKKALKSDIGQYTC----DCGTDKTSGKLDIEDR 5733



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 32/142 (22%), Positives = 62/142 (43%), Gaps = 14/142 (9%)

Query: 306   HSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL---E 362
             H   F V+  + AG ++  +++            + A++    P     P+ K  +    
Sbjct: 16135 HRYEFRVIARNAAGVFSEPSESTGA---------ITARDEVDPPRISMDPKYKDTIVVHA 16185

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G+S K++  I   P P + W + ++ +  NT R+ +   +    +L +KD  + D+G Y 
Sbjct: 16186 GESFKVDADIYGKPIPTIQWIKGDQELS-NTARLEIKSTDFA-TSLSVKDAVRVDSGNYI 16243

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             + A N AG  +    + V  RP
Sbjct: 16244 LKAKNVAGERSVTVNVKVLDRP 16265



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 30/129 (23%), Positives = 58/129 (44%), Gaps = 7/129 (5%)

Query: 321   YACVAKNRAGEATFTVQLD--VLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAI 375
             +  +AKN AG  +        + AK+    P     P+ +  +    G++ +LE  +   
Sbjct: 17221 FRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGK 17280

Query: 376   PPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCN 435
             P P + W R ++ ++  + R  + ++   +  L++KD  + D G Y + A N AG  +  
Sbjct: 17281 PLPTIEWLRGDKEIE-ESARCEI-KNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFP 17338

Query: 436   TRLDVTARP 444
               + V  RP
Sbjct: 17339 VNVKVLDRP 17347



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 24/98 (24%), Positives = 41/98 (41%)

Query: 250   PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
             P F ++  N    EG+    + +VSG+P P + W  +G+ +      ++I      ++L 
Sbjct: 25423 PMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALH 25482

Query: 310   FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKR 347
                    D G Y   A N AG  +    L V    +K+
Sbjct: 25483 IRDTLPEDTGYYRVTATNTAGSTSCQAHLQVERLRYKK 25520



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 40/158 (25%), Positives = 61/158 (38%), Gaps = 13/158 (8%)

Query: 277  PAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTV 336
            P   V W  + + +Q  D  K I  EK +H L+    R SDAG Y  VA      A   V
Sbjct: 3038 PDITVQWMKDDQELQITDRIK-IQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFV 3096

Query: 337  Q-LDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDR 395
            +  DV  +  K+    I K ++    E +   ++            W ++   + F    
Sbjct: 3097 EGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAH----------WYKDGIEINFQVQE 3146

Query: 396  ISLYQDNTGRVTLLIKDVNKKDAGWYT-VSAVNEAGVT 432
               Y        + I +  + DAG YT V+  N + VT
Sbjct: 3147 RHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVT 3184



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 23/82 (28%), Positives = 42/82 (51%), Gaps = 2/82 (2%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G ++++  ++   P P + W +  +++     R+ L QD   RV L IK+  + D G Y 
Sbjct: 11551 GQTIRILARVKGRPEPDITWTKEGKVL-VREKRVDLIQD-LPRVELQIKEAVRADHGKYI 11608

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             +SA N +G    +  ++V  RP
Sbjct: 11609 ISAKNSSGHAQGSAIVNVLDRP 11630



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)

Query: 268   RMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKN 327
             R+   + G PAP VSW   G    + D    + S     +LI    + SDAG Y    KN
Sbjct: 13629 RLKIPIKGKPAPSVSWK-KGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKN 13687

Query: 328   RAGEATFTVQLDVLAK 343
              AG    T+ + V+ K
Sbjct: 13688 VAGTKEGTISIKVVGK 13703



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 21/91 (23%), Positives = 46/91 (50%), Gaps = 1/91 (1%)

Query: 253   IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEV 312
             ++  E +    G   ++   +SG PAP + WY + + +Q++ L   + +   L S++ + 
Sbjct: 20504 LEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNAL-VCVENTTDLASILIKD 20562

Query: 313   VRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
                 ++G Y    +N  G A+ T+++ +L K
Sbjct: 20563 ADRLNSGCYELKLRNAMGSASATIRVQILDK 20593



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 6/83 (7%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKD-VNKKDAGWY 421
             G S++L   +S  PPP + W +    +   +  I    D T   +LLI D VN+ DAG Y
Sbjct: 23089 GASLRLMVSVSGRPPPVITWSKQG--IDLASRAII---DTTESYSLLIVDKVNRYDAGKY 23143

Query: 422   TVSAVNEAGVTTCNTRLDVTARP 444
             T+ A N++G  +    + V   P
Sbjct: 23144 TIEAENQSGKKSATVLVKVYDTP 23166



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 23/85 (27%), Positives = 42/85 (49%), Gaps = 2/85 (2%)

Query: 360  VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
            V  G  ++L   ++  P PK+ W +  +M+     RI++ ++   + T+ I D  + D G
Sbjct: 7330 VKAGTKIELPATVTGKPEPKITWTKA-DMILKQDKRITI-ENVPKKSTVTIVDSKRSDTG 7387

Query: 420  WYTVSAVNEAGVTTCNTRLDVTARP 444
             Y + AVN  G  T    ++V  +P
Sbjct: 7388 TYIIEAVNVCGRATAVVEVNVLDKP 7412



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 36/140 (25%), Positives = 63/140 (45%), Gaps = 12/140 (8%)

Query: 321   YACVAKNRAGEATFT-VQLDVLAKEHKRAPMFIYKP---QSKKVLEGDSVKLECQISAIP 376
             +  +A N AGE+    V   VL K+    P  I      + + +  GD+++L   I  +P
Sbjct: 10815 FRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVP 10874

Query: 377   PPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
              PK+ WK+ +        RI +    +    L I++   +D G Y+++  N AG  T + 
Sbjct: 10875 FPKVTWKKEDRDAPTKA-RIDVTPVGS---KLEIRNAAHEDGGIYSLTVENPAGSKTVSV 10930

Query: 437   RLDVTARPNQTLPAPKQLRV 456
             ++ V  +P      P+ L V
Sbjct: 10931 KVLVLDKPG----PPRDLEV 10946



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 37/128 (28%), Positives = 62/128 (48%), Gaps = 14/128 (10%)

Query: 325   AKNRAGEAT-FTVQLDVLAKEHKRAP---MFIYKPQSKKVLEGDSVKLECQISAIPPPKL 380
             A+N+AG +    + L VL KE    P   M  +   +  V  G ++K++  IS  P PK+
Sbjct: 20077 AENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKV 20136

Query: 381   FWKRNN----EMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
                R+       ++FNT+   +  +N   +T+ +K+    DAG Y ++A N +G T    
Sbjct: 20137 TLSRDGVPLKATMRFNTE---ITAEN---LTINLKESVTADAGRYEITAANSSGTTKAFI 20190

Query: 437   RLDVTARP 444
              + V  RP
Sbjct: 20191 NIVVLDRP 20198



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 25/83 (30%), Positives = 42/83 (50%), Gaps = 1/83 (1%)

Query: 259   MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDA 318
             +++  G+  R+  +V G P PD++W   G+ +  +    +I     +   I E VRA D 
Sbjct: 11546 ITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRA-DH 11604

Query: 319   GAYACVAKNRAGEATFTVQLDVL 341
             G Y   AKN +G A  +  ++VL
Sbjct: 11605 GKYIISAKNSSGHAQGSAIVNVL 11627



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 56/245 (22%), Positives = 99/245 (40%), Gaps = 21/245 (8%)

Query: 106   DYNSSKIPSAMDSN---YQQSSAGQPINAKPSQ-TANAKPI--PRTPDHEIQGSKEALIQ 159
             +Y ++ +   +D     Y ++SAG    + PS+ T    P+  P TPD+ I  ++E +  
Sbjct: 21443 EYRATGLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDY-IDVTRETIT- 21500

Query: 160   DLERKLKCKDTLLHNGNQRLTY--EEKMARRLLGPQNAAAVFQAQDD-SGAQDSQQHNSE 216
                  LK    L   G++ + Y  E++         N   V + Q   +G     ++   
Sbjct: 21501 -----LKWNPPLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFR 21555

Query: 217   H-ARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSG 275
               AR  V T    S+S+      D++      + P +    + + I  G   R+   V G
Sbjct: 21556 IIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYF---DGLIIKSGESLRIKALVQG 21612

Query: 276   LPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFT 335
              P P V+W+ +G  ++   ++  I    G  SL          G Y   AKN +G A   
Sbjct: 21613 RPVPRVTWFKDGVEIEK-RMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAE 21671

Query: 336   VQLDV 340
             +++ V
Sbjct: 21672 IKVKV 21676



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 23/75 (30%), Positives = 37/75 (49%), Gaps = 1/75 (1%)

Query: 269   MDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNR 328
             +D  +SG PAP V+W L    ++  D    I + K   +L  +     D+G Y    +N 
Sbjct: 22295 IDVPISGRPAPKVTWKLEEMRLKETD-RVSITTTKDRTTLTVKDSMRGDSGRYFLTLENT 22353

Query: 329   AGEATFTVQLDVLAK 343
             AG  TF+V + V+ +
Sbjct: 22354 AGVKTFSVTVVVIGR 22368



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 42/153 (27%), Positives = 60/153 (39%), Gaps = 16/153 (10%)

Query: 276  LPAPDV--SWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEAT 333
            L  PDV   W L G+ + +    ++I   K  H LI    +    G  +  A N    A 
Sbjct: 5402 LSEPDVHGQWKLKGQPLTASPDCEIIEDGKK-HILILHNCQLGMTGEVSFQAANAKSAAN 5460

Query: 334  FTVQLDVLAKEHKRAPMFIYKPQSK-KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFN 392
              V         K  P+    P S  KV E D  K EC++S  P    + K   E+    
Sbjct: 5461 LKV---------KELPLIFITPLSDVKVFEKDEAKFECEVSREPKTFRWLKGTQEIT--G 5509

Query: 393  TDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSA 425
             DR  L +D T + +++IK    +D   Y   A
Sbjct: 5510 DDRFELIKDGT-KHSMVIKSAAFEDEAKYMFEA 5541



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 26/138 (18%), Positives = 62/138 (44%), Gaps = 9/138 (6%)

Query: 317   DAGAYACVAKNRAGEATFTVQLD--VLAKEHKRAPMFIYKPQ---SKKVLEGDSVKLECQ 371
             D   +  +A+N  G  +   Q    ++ ++    P+  + P+      +  G+S++++  
Sbjct: 21550 DRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKAL 21609

Query: 372   ISAIPPPKLFWKRNNEMVQFNTDRISL-YQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
             +   P P++ W ++   ++    R+++   D  G  +L ++D  +   G YTV A N +G
Sbjct: 21610 VQGRPVPRVTWFKDGVEIE---KRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASG 21666

Query: 431   VTTCNTRLDVTARPNQTL 448
                   ++ V   P + +
Sbjct: 21667 SAKAEIKVKVQDTPGKVV 21684



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 21/82 (25%), Positives = 41/82 (50%), Gaps = 2/82 (2%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G  + L+  +   P PK+ W + ++ +    +++SL Q    R T +IK  ++ D+G YT
Sbjct: 22690 GSDLVLDAAVGGKPEPKIIWTKGDKELDL-CEKVSL-QYTGKRATAVIKFCDRSDSGKYT 22747

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             ++  N +G    +  + V   P
Sbjct: 22748 LTVKNASGTKAVSVMVKVLDSP 22769



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 25/84 (29%), Positives = 42/84 (50%), Gaps = 3/84 (3%)

Query: 257   ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRAS 316
             + ++I  G   R+   VSG P P ++W   G  + S     +I + +    LI + V   
Sbjct: 23082 KTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLAS---RAIIDTTESYSLLIVDKVNRY 23138

Query: 317   DAGAYACVAKNRAGEATFTVQLDV 340
             DAG Y   A+N++G+ + TV + V
Sbjct: 23139 DAGKYTIEAENQSGKKSATVLVKV 23162



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 29/115 (25%), Positives = 42/115 (36%), Gaps = 12/115 (10%)

Query: 348   APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
             A   + KP+S  V EG+S +  C     P P + W R  +++  +T           + T
Sbjct: 26188 AARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVL--STSARHQVTTTKYKST 26245

Query: 408   LLIKDVNKKDAGWYTVSAVNEAGVTTCN----------TRLDVTARPNQTLPAPK 452
               I  V   D G Y+V   N  G               T   VT+ P    P P+
Sbjct: 26246 FEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPR 26300



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 24/69 (34%), Positives = 37/69 (53%), Gaps = 4/69 (5%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLL-IKDVNKKDAGWY 421
             G +++L   +   PPPK+ W + N  ++   DRI L   +T   T L  ++VNK DAG Y
Sbjct: 13336 GVTMRLYVPVKGRPPPKITWSKPNVNLR---DRIGLDIKSTDFDTFLRCENVNKYDAGKY 13392

Query: 422   TVSAVNEAG 430
              ++  N  G
Sbjct: 13393 ILTLENSCG 13401



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 27/92 (29%), Positives = 43/92 (46%), Gaps = 11/92 (11%)

Query: 341   LAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTD-RI 396
             +AKE +  P+F    + +K L    G S  +       P P + W + +      TD R 
Sbjct: 19804 IAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPD------TDLRT 19857

Query: 397   SLYQDNT-GRVTLLIKDVNKKDAGWYTVSAVN 427
               Y D T  R +L I++ N+ D+G YT++  N
Sbjct: 19858 RAYVDTTDSRTSLTIENANRNDSGKYTLTIQN 19889



 Score = 37.4 bits (85), Expect = 0.032
 Identities = 27/99 (27%), Positives = 41/99 (41%), Gaps = 3/99 (3%)

Query: 248   YPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQ-SDDLHKMIVSEKGLH 306
             + PR      +  +  G+  R    V   P  +V WY NG  +Q S  +H    +  G+ 
Sbjct: 26000 HAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIH--YTNTSGVL 26057

Query: 307   SLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEH 345
             +L        D+G Y  V  N  GEA+    LDV   ++
Sbjct: 26058 TLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDY 26096



 Score = 37.0 bits (84), Expect = 0.042
 Identities = 26/93 (27%), Positives = 45/93 (48%), Gaps = 4/93 (4%)

Query: 253   IQVPENM-SIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI-F 310
             +++P N  SI  G   +++  V G P P++SW  +G  ++     ++ V E    +++  
Sbjct: 17942 LKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTT--RVNVEETATSTVLHI 17999

Query: 311   EVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
             +     D G Y   A N AG AT  + + VL K
Sbjct: 18000 KEGNKDDFGKYTVTATNSAGTATENLSVIVLEK 18032



 Score = 37.0 bits (84), Expect = 0.042
 Identities = 28/120 (23%), Positives = 54/120 (45%), Gaps = 8/120 (6%)

Query: 227   VRSRSTSRGDVNDQDAIQEKFYPPRF---IQVPENMSIDEGRFCRMDFKVSGLPAPDVSW 283
             V   S S G +  +D ++    PPR    ++  + + +  G   +++  ++G P P +SW
Sbjct: 19396 VSEPSESTGPIIVKDDVE----PPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISW 19451

Query: 284   YLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
               +G  ++     ++I ++      + + +R  D G Y    KN AG  +  V   VL K
Sbjct: 19452 AKDGIEIEERARTEIISTDNHTLLTVKDCIR-RDTGQYVLTLKNVAGTRSVAVNCKVLDK 19510



 Score = 36.6 bits (83), Expect = 0.054
 Identities = 38/139 (27%), Positives = 63/139 (45%), Gaps = 15/139 (10%)

Query: 325   AKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAIPPPKLF 381
             A N AG     V  DV   E + AP F    + ++ L    G S+++   I   P P++ 
Sbjct: 14378 AINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVT 14437

Query: 382   WKRNNEMVQFNTDRISLYQDNTGRVTLL-IKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
             W ++N  ++   +R ++  +NT   TLL I + N+ D G + ++  N AG  +    + V
Sbjct: 14438 WTKDNINLK---NRANI--ENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRV 14492

Query: 441   TARPNQTLPAPKQLRVRPT 459
                P         L +RPT
Sbjct: 14493 LDTPGPV------LNLRPT 14505



 Score = 36.6 bits (83), Expect = 0.054
 Identities = 30/132 (22%), Positives = 55/132 (41%), Gaps = 5/132 (3%)

Query: 347   RAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV 406
             +AP F  + ++  V    +  L C+++  P P + W R  + +  +  +  + +   G  
Sbjct: 24554 QAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYH 24613

Query: 407   TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLAL 466
              L+I  V   DA  Y V A N+ G  +    L+V       LP     +         AL
Sbjct: 24614 QLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLP-----KTLEGMGAVHAL 24668

Query: 467   NGKGLNVKQAFN 478
              G+ +++K  F+
Sbjct: 24669 RGEVVSIKIPFS 24680



 Score = 35.8 bits (81), Expect = 0.093
 Identities = 30/120 (25%), Positives = 56/120 (46%), Gaps = 12/120 (10%)

Query: 231  STSRGDVNDQDAIQEKFYPPRFIQV--PENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGR 288
            S + G++   D IQE+  P  FI +   + +    G   R+   + G P P  SW  +G+
Sbjct: 9421 SDTTGEIPATD-IQEE--PEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSWEFDGK 9477

Query: 289  TVQS--DDLHKM-----IVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
              ++  D +H +     + + +    +I    + S  G Y+  AKN+AG+ T   ++ V+
Sbjct: 9478 AKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVM 9537



 Score = 35.8 bits (81), Expect = 0.093
 Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 5/95 (5%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
             P   +   + ++I  G    +  + SG P P VSW+ +   V  DD   +  +     +L
Sbjct: 10446 PTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPA---TL 10502

Query: 309   IFEVVRA--SDAGAYACVAKNRAGEATFTVQLDVL 341
               E ++A  SD+G Y  V +N  G      Q++V+
Sbjct: 10503 ALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVV 10537



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 24/100 (24%), Positives = 44/100 (44%), Gaps = 10/100 (10%)

Query: 363  GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT------LLIKDVNKK 416
            G  +++   I   P PK  W+ + +  +   D +    ++    T      ++I +  + 
Sbjct: 9453 GSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRS 9512

Query: 417  DAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRV 456
              G Y+++A N+AG  T N R+ V   P      PK L+V
Sbjct: 9513 HTGKYSITAKNKAGQKTANCRVKVMDVPG----PPKDLKV 9548



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 42/166 (25%), Positives = 70/166 (42%), Gaps = 16/166 (9%)

Query: 298   MIVSEKGLHSLIFEVVRASDAGAY--ACVAKNRAGEATFT-VQLDVLAKEHKRAPMFIYK 354
             M     G++    EV +  +   Y     A N+AG      V   ++ +E   AP     
Sbjct: 16514 MCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLD 16573

Query: 355   PQSKKVLE---GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIK 411
              + +K++    G S++L   I   P P++ W + +  +     R +   D T   T L+ 
Sbjct: 16574 LELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEI-----RDAAIIDVTSSFTSLVL 16628

Query: 412   D-VNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRV 456
             D VN+ D+G YT++  N +G  +      VT R   T   P  L+V
Sbjct: 16629 DNVNRYDSGKYTLTLENSSGTKSA----FVTVRVLDTPSPPVNLKV 16670



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 25/110 (22%), Positives = 50/110 (45%), Gaps = 2/110 (1%)

Query: 340   VLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLY 399
             V+A++ +  P       +  V   + +K++      P   + W+++ + ++  T R+++ 
Sbjct: 19014 VIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLK-ETTRVNVS 19072

Query: 400   QDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLP 449
                T   +L IK+ +K+D G Y +   N AG  T    + V  RP    P
Sbjct: 19073 SSKTV-TSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGP 19121



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 25/94 (26%), Positives = 43/94 (45%), Gaps = 2/94 (2%)

Query: 348   APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
             AP    + +S +V  G + +    + + P  ++ W  N   +Q  + +I  Y + +G +T
Sbjct: 26001 APRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQ-ESSKIH-YTNTSGVLT 26058

Query: 408   LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVT 441
             L I D +  D+G Y     N  G  +    LDVT
Sbjct: 26059 LEILDCHTDDSGTYRAVCTNYKGEASDYATLDVT 26092



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 26/114 (22%), Positives = 50/114 (43%), Gaps = 8/114 (7%)

Query: 231   STSRGDVNDQDAIQEKFYPPRFIQVP---ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNG 287
             S S G +  +D ++     PR    P   + + ++ G   R++  V G P P + W    
Sbjct: 17236 SDSTGPITAKDEVEL----PRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGD 17291

Query: 288   RTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
             + ++     ++  ++     ++ + +R  D G Y   A N AG  +F V + VL
Sbjct: 17292 KEIEESARCEIKNTDFKALLIVKDAIRI-DGGQYILRASNVAGSKSFPVNVKVL 17344



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 22/104 (21%), Positives = 44/104 (42%), Gaps = 5/104 (4%)

Query: 240   QDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMI 299
             +D + E    P F     + S+  G+  +++  +SG P P ++W  +G  ++       +
Sbjct: 16852 KDLVIEPDVKPAF----SSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLK-QTTRINV 16906

Query: 300   VSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
                  L +L  +     D G Y     N  G+ T ++++  L K
Sbjct: 16907 TDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDK 16950



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 22/69 (31%), Positives = 34/69 (49%), Gaps = 3/69 (4%)

Query: 257  ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGL-HSLIFEVVRA 315
            +++++ EG    ++ KVS      V WYLN   ++ DD  + IV  KG    L+     A
Sbjct: 2406 KDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIV--KGTKQRLVINRTHA 2463

Query: 316  SDAGAYACV 324
            SD G Y  +
Sbjct: 2464 SDEGPYKLI 2472



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 27/126 (21%), Positives = 55/126 (43%), Gaps = 12/126 (9%)

Query: 253   IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEV 312
             ++  + + +  G   R++  VSG P P + W  +G+ ++     ++ +++    +L+ + 
Sbjct: 15093 VKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFST-NLVNKD 15151

Query: 313   VRASDAGAYACVAKNRAGEATFTVQLDVLAKE-HKRAPMFIYKPQSKKVLEGDSVKLECQ 371
                 D+GAY   A N  G A     + VL +      P+ + +  S+K          C 
Sbjct: 15152 STRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEK----------CV 15201

Query: 372   ISAIPP 377
             +S  PP
Sbjct: 15202 LSWFPP 15207



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 20/85 (23%), Positives = 37/85 (43%), Gaps = 2/85 (2%)

Query: 360   VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
             V  G+ +K+   I+  P P + W ++   ++       +  DN     L +KD  ++D G
Sbjct: 19429 VKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDN--HTLLTVKDCIRRDTG 19486

Query: 420   WYTVSAVNEAGVTTCNTRLDVTARP 444
              Y ++  N AG  +      V  +P
Sbjct: 19487 QYVLTLKNVAGTRSVAVNCKVLDKP 19511



 Score = 33.9 bits (76), Expect = 0.35
 Identities = 39/137 (28%), Positives = 60/137 (43%), Gaps = 11/137 (8%)

Query: 362  EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKD-AGW 420
            EGD V L   I+     ++ W   N++V  +     L   NT   TL+I  VN +D  G 
Sbjct: 4381 EGDIVHLTTSITNAK--EVNWYFENKLVPSDEKFKCLQDQNT--YTLVIDKVNTEDHQGE 4436

Query: 421  YTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNPE 480
            Y   A+N++G T  + +L V  R     P  K+ ++ P       L      ++ A  P 
Sbjct: 4437 YVCEALNDSGKTATSAKLTVVKR---AAPVIKR-KIEPLEVALGHLAKFTCEIQSA--PN 4490

Query: 481  GEFQRLAAQSGLYESEE 497
              FQ   A   +YES++
Sbjct: 4491 VRFQWFKAGREIYESDK 4507



 Score = 33.9 bits (76), Expect = 0.35
 Identities = 22/94 (23%), Positives = 37/94 (39%), Gaps = 4/94 (4%)

Query: 356   QSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNK 415
             Q+  V  G S++L       P P   W + +  +    D            TL +++ N+
Sbjct: 21993 QTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRAD----IHTTDSFSTLTVENCNR 22048

Query: 416   KDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLP 449
              DAG YT++  N +G  +    + V   P    P
Sbjct: 22049 NDAGKYTLTVENNSGSKSITFTVKVLDTPGPPGP 22082



 Score = 33.5 bits (75), Expect = 0.46
 Identities = 36/159 (22%), Positives = 62/159 (38%), Gaps = 16/159 (10%)

Query: 198   VFQAQDDSGAQDSQQHNSEHARLQVP------TSQVRSRSTSRGDVNDQDAIQEKFYPPR 251
             V +A  D+  + +   N +  R +V         Q R  + ++   +D   + +K YP  
Sbjct: 13255 VKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKD 13314

Query: 252   FIQVPEN---------MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSE 302
              +  PE          + +  G   R+   V G P P ++W      ++ D +   I S 
Sbjct: 13315 ILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLR-DRIGLDIKST 13373

Query: 303   KGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
                  L  E V   DAG Y    +N  G+  +T+ + VL
Sbjct: 13374 DFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVL 13412



 Score = 33.1 bits (74), Expect = 0.60
 Identities = 23/85 (27%), Positives = 38/85 (44%), Gaps = 2/85 (2%)

Query: 360   VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
             V  G +V+    I  +P P   W  +   ++ + +  ++  DN   V L IK+  ++D G
Sbjct: 11150 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTD-EHYTVETDNFSSV-LTIKNCLRRDTG 11207

Query: 420   WYTVSAVNEAGVTTCNTRLDVTARP 444
              Y ++  N AG  T    L V   P
Sbjct: 11208 EYQITVSNAAGSKTVAVHLTVLDVP 11232



 Score = 33.1 bits (74), Expect = 0.60
 Identities = 25/95 (26%), Positives = 39/95 (41%), Gaps = 1/95 (1%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
             PP F  +    ++  G   ++D    G P P V+W+ +   ++         +E      
Sbjct: 15775 PPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLT 15834

Query: 309   IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
             I +  R  D G Y     N AGEA  T+ + VL K
Sbjct: 15835 IKDACR-EDVGHYVVKLTNSAGEAIETLNVIVLDK 15868



 Score = 32.7 bits (73), Expect = 0.78
 Identities = 22/95 (23%), Positives = 38/95 (40%), Gaps = 7/95 (7%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
             P + I VP       GR   +   ++G P P  SW+  G  ++  +    + +   +  L
Sbjct: 23372 PQKTIHVPA------GRPVELVIPIAGRPPPAASWFFAGSKLRESE-RVTVETHTKVAKL 23424

Query: 309   IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
                     D G Y    KN  G  + T+++ +L K
Sbjct: 23425 TIRETTIRDTGEYTLELKNVTGTTSETIKVIILDK 23459



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 30/134 (22%), Positives = 44/134 (32%), Gaps = 9/134 (6%)

Query: 216  EHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPP----RFIQVPENMSIDEGRFCRMDF 271
            EH   +     V     S   +     IQ+   PP    R     + + +  G    +  
Sbjct: 8989 EHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPA 9048

Query: 272  KVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHS-----LIFEVVRASDAGAYACVAK 326
             V+GLP P + W  N   ++       I  E+   S     L        D G Y   A 
Sbjct: 9049 DVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTAS 9108

Query: 327  NRAGEATFTVQLDV 340
            NR G     V ++V
Sbjct: 9109 NRLGSVFRNVHVEV 9122



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 33/126 (26%), Positives = 58/126 (46%), Gaps = 8/126 (6%)

Query: 365   SVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIK-DVNKKDAGWYTV 423
             +++L   I   P P++ W R++     + D+ S+  ++T   TLLI  +VN+ D+G Y +
Sbjct: 15505 TLRLFVPIKGRPAPEVKWARDHGE---SLDKASI--ESTSSYTLLIVGNVNRFDSGKYIL 15559

Query: 424   SAVNEAGVTTC--NTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNPEG 481
             +  N +G  +   N R+  T  P Q L   +  +   T +    L   G  +K     + 
Sbjct: 15560 TVENSSGSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVEKR 15619

Query: 482   EFQRLA 487
             E  R A
Sbjct: 15620 ESTRKA 15625



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 23/87 (26%), Positives = 34/87 (39%), Gaps = 1/87 (1%)

Query: 273   VSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEA 332
             + G P P  SW   G+ ++  D+   I S      L  +     DAG Y   A N  G  
Sbjct: 14031 ILGKPLPKSSWSKAGKDIRPSDI-TQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTK 14089

Query: 333   TFTVQLDVLAKEHKRAPMFIYKPQSKK 359
                V++ VL       P+ I    ++K
Sbjct: 14090 VEHVKVTVLDVPGPPGPVEISNVSAEK 14116



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 26/109 (23%), Positives = 46/109 (42%), Gaps = 6/109 (5%)

Query: 236   DVNDQDAIQEKFYPPRF---IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQS 292
             DV     ++EK   P     +++ + ++I  G   R+   + G P P+V W   G+    
Sbjct: 16554 DVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKW---GKVDGE 16610

Query: 293   DDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
                  +I       SL+ + V   D+G Y    +N +G  +  V + VL
Sbjct: 16611 IRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVL 16659



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 20/82 (24%), Positives = 40/82 (48%), Gaps = 2/82 (2%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G  V+L   I+  PPP   W      ++  ++R+++ + +T    L I++   +D G YT
Sbjct: 23381 GRPVELVIPIAGRPPPAASWFFAGSKLR-ESERVTV-ETHTKVAKLTIRETTIRDTGEYT 23438

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             +   N  G T+   ++ +  +P
Sbjct: 23439 LELKNVTGTTSETIKVIILDKP 23460



 Score = 30.8 bits (68), Expect = 3.0
 Identities = 23/87 (26%), Positives = 37/87 (42%), Gaps = 14/87 (16%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT-----LLIKDVNKKD 417
             G  +++   +S  PPP + W  N           +L Q+ T   T     ++IK+  +  
Sbjct: 10167 GGVIRIIAYVSGKPPPTVTWNMNER---------TLPQEATIETTAISSSMVIKNCQRSH 10217

Query: 418   AGWYTVSAVNEAGVTTCNTRLDVTARP 444
              G Y++ A NEAG       +DV   P
Sbjct: 10218 QGVYSLLAKNEAGERKKTIIVDVLDVP 10244



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 24/105 (22%), Positives = 43/105 (40%), Gaps = 13/105 (12%)

Query: 274  SGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEAT 333
            +G P P  +W    + +++ D  KM  +      L+      SD G Y    +NR    +
Sbjct: 7047 TGYPRPTATWCFGDKVLETGDRVKM-KTLSAYAELVISPSERSDKGIYTLKLENRVKTIS 7105

Query: 334  FTVQLDVLAKEHKRAPMFIYKPQSKKVLE-GDSVKLECQISAIPP 377
              + ++V+A           +P + K L+ GD  K    ++  PP
Sbjct: 7106 GEIDVNVIA-----------RPSAPKELKFGDITKDSVHLTWEPP 7139



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 25/113 (22%), Positives = 45/113 (39%), Gaps = 5/113 (4%)

Query: 231   STSRGDVNDQDAIQ--EKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGR 288
             S S G +  +D I        P++  V   + +  G    ++  + G P PDV W  +G+
Sbjct: 18318 SDSSGAITARDEIDAPNASLDPKYKDV---IVVHAGETFVLEADIRGKPIPDVVWSKDGK 18374

Query: 289   TVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
              ++       I S     +L+ +    +D G Y     N  G  +  + + VL
Sbjct: 18375 ELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVL 18427



 Score = 30.0 bits (66), Expect = 5.1
 Identities = 25/96 (26%), Positives = 48/96 (50%), Gaps = 7/96 (7%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLL-IKDVNKKDAGWY 421
             G+ V++       PPP + W+++ + +  +  R S+  +NT   +LL I  V + D G Y
Sbjct: 20914 GEDVQVLIPFKGRPPPTVTWRKDEKNLGSDA-RYSI--ENTDSSSLLTIPQVTRNDTGKY 20970

Query: 422   TVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVR 457
              ++  N  G    +T   V+ +   T  A ++L+V+
Sbjct: 20971 ILTIENGVGEPKSST---VSVKVLDTPAACQKLQVK 21003



 Score = 30.0 bits (66), Expect = 5.1
 Identities = 16/61 (26%), Positives = 26/61 (42%), Gaps = 2/61 (3%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G +V LE      P P + W ++   +         +     ++TL IK+  K+  G YT
Sbjct: 21206 GHNVHLELPYKGKPKPSISWLKDG--LPLKESEFVRFSKTENKITLSIKNAKKEHGGKYT 21263

Query: 423   V 423
             V
Sbjct: 21264 V 21264



 Score = 29.6 bits (65), Expect = 6.6
 Identities = 24/102 (23%), Positives = 42/102 (41%), Gaps = 8/102 (7%)

Query: 244   QEKFYPPRFIQVPENMSIDEGRFC---RMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIV 300
             +++  PP      +   +   R C   R+   + G PAP+V W  +      + L K  +
Sbjct: 15480 EDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARD----HGESLDKASI 15535

Query: 301   SEKGLHS-LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
                  ++ LI   V   D+G Y    +N +G  +  V + VL
Sbjct: 15536 ESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVL 15577



 Score = 29.6 bits (65), Expect = 6.6
 Identities = 21/84 (25%), Positives = 36/84 (42%), Gaps = 3/84 (3%)

Query: 259   MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL-IFEVVRASD 317
             ++I  G    +D  V G P P + W    + +  D   K+ +   G  +  + +    SD
Sbjct: 22685 VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKEL--DLCEKVSLQYTGKRATAVIKFCDRSD 22742

Query: 318   AGAYACVAKNRAGEATFTVQLDVL 341
             +G Y    KN +G    +V + VL
Sbjct: 22743 SGKYTLTVKNASGTKAVSVMVKVL 22766



 Score = 29.3 bits (64), Expect = 8.7
 Identities = 18/86 (20%), Positives = 37/86 (43%), Gaps = 4/86 (4%)

Query: 360   VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
             V +G  ++L   I   P P   W +  + +     + ++   +     L+IK+ ++ D+G
Sbjct: 23776 VRQGGVIRLTIPIKGKPFPICKWTKEGQDIS----KRAMIATSETHTELVIKEADRGDSG 23831

Query: 420   WYTVSAVNEAGVTTCNTRLDVTARPN 445
              Y +   N+ G      ++ V   PN
Sbjct: 23832 TYDLVLENKCGKKAVYIKVRVIGSPN 23857


>gi|110349715 titin isoform N2-B [Homo sapiens]
          Length = 26926

 Score =  127 bits (320), Expect = 2e-29
 Identities = 66/216 (30%), Positives = 115/216 (53%)

Query: 245  EKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG 304
            E+ Y P F+  P +    EG+  R D KV G P P+  W+ +G+ + +D  HK+++ E G
Sbjct: 1406 ERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDG 1465

Query: 305  LHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGD 364
              SLI      SD+G +  VA+NRAG ++ +V L V A EH+  PMF+ K ++  + EG 
Sbjct: 1466 TQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGS 1525

Query: 365  SVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVS 424
             ++++ + +  P P + W +N++++  +       +   G   L I     +D+ WYT +
Sbjct: 1526 RLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTAT 1585

Query: 425  AVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTF 460
            A+N+AG  T   +++V     +  P  K +  R T+
Sbjct: 1586 AINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTY 1621



 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 62/198 (31%), Positives = 92/198 (46%), Gaps = 7/198 (3%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIV--SEKGLH 306
             PP F     N +   G   R    ++  P P V+WY +G+ ++  D  K     S+KGL+
Sbjct: 25192 PPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLY 25251

Query: 307   SLIFEVVRASDAGAYACVAKNRAGE----ATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE 362
              L    V   D   Y  VA+N+ GE    A  TV L     +    PMF     + +  E
Sbjct: 25252 QLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQE 25311

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G SV  E ++S IPPP L W+++ + +    + I +  +      L I+D   +D G+Y 
Sbjct: 25312 GQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPN-IEIIHEGLDYYALHIRDTLPEDTGYYR 25370

Query: 423   VSAVNEAGVTTCNTRLDV 440
             V+A N AG T+C   L V
Sbjct: 25371 VTATNTAGSTSCQAHLQV 25388



 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 62/213 (29%), Positives = 109/213 (51%), Gaps = 13/213 (6%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVS-EKGLHSL 308
           P F Q  +++ + EG     +  +SG P P+VSW+ +G+ + +  L  + +S   G   L
Sbjct: 6   PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65

Query: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
               V  +++G Y+  A N +G+AT T +L  L K     P F+ + QS  V +G  V+L
Sbjct: 66  TIPAVTKANSGRYSLKATNGSGQATSTAEL--LVKAETAPPNFVQRLQSMTVRQGSQVRL 123

Query: 369 ECQISAIPPPKLFWKRNNEMVQFNTD-RISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
           + +++ IP P + + R+   +Q + D +IS   D     +LLI +   +D+G Y+V+A N
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGD---LYSLLIAEAYPEDSGTYSVNATN 180

Query: 428 EAGVTTCNTRL------DVTARPNQTLPAPKQL 454
             G  T    L      +V A+  +T+ +  Q+
Sbjct: 181 SVGRATSTAELLVQGEEEVPAKKTKTIVSTAQI 213



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 60/231 (25%), Positives = 94/231 (40%), Gaps = 42/231 (18%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP  +   +N+++ EG    ++  +SG P+P V+WY     ++S  +   I  + G+  L
Sbjct: 896  PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESS-IDFQITFQSGIARL 954

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDV----------------LAKEHKR----- 347
            +     A D+G + C A N AG  + +  L V                   E KR     
Sbjct: 955  MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESR 1014

Query: 348  --------------------APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNE 387
                                AP FI KP  +K++EG SV   CQ+   P P ++WK++  
Sbjct: 1015 DVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGV 1074

Query: 388  MVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 438
             +         Y   TG   L+I      DAG YT+   N+ G T+ +  L
Sbjct: 1075 PLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 55/182 (30%), Positives = 94/182 (51%), Gaps = 6/182 (3%)

Query: 259   MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDA 318
             MSI+EG+  R+  K +   A DV W LNG  + + + ++  VS     +L  +     D 
Sbjct: 26551 MSINEGQ--RLVLKANIAGATDVKWVLNGVELTNSEEYRYGVSGSD-QTLTIKQASHRDE 26607

Query: 319   GAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPP 378
             G   C++K + G       L  L+KE   AP FI +P+S+ + EG +V   C+IS  P P
Sbjct: 26608 GILTCISKTKEGIVKCQYDL-TLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSP 26666

Query: 379   KLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 438
             ++ W +NN  +  +++ +S+ + +    +L I++ +  D+G YT+ A N  G  +    L
Sbjct: 26667 EIEWFKNNLPISISSN-VSISR-SRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASL 26724

Query: 439   DV 440
              V
Sbjct: 26725 MV 26726



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 53/197 (26%), Positives = 83/197 (42%), Gaps = 2/197 (1%)

Query: 250   PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG-LHSL 308
             P F +   N+++       +  KV+G P P V WY  G+ + +D L   I   KG  H L
Sbjct: 24431 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQL 24490

Query: 309   IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
             I   V   DA  Y   A N+ G  + T  L+V        P  +    +   L G+ V +
Sbjct: 24491 IIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSI 24550

Query: 369   ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
             +   S  P P + W++  +++  N     +    +    +    V +KDAG+Y V A N 
Sbjct: 24551 KIPFSGKPDPVITWQKGQDLID-NNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNR 24609

Query: 429   AGVTTCNTRLDVTARPN 445
              G+      LDV   P+
Sbjct: 24610 FGIDQKTVELDVADVPD 24626



 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 53/229 (23%), Positives = 88/229 (38%), Gaps = 22/229 (9%)

Query: 250  PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
            P FI+   N  I  G    +   V G+P P + W+ NG  +     +K +      HSLI
Sbjct: 3457 PIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDD-HSLI 3515

Query: 310  FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK--EHKRA------------------P 349
                +  D G Y C+A N  G+   +  L + +K   HK                    P
Sbjct: 3516 ILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKLGGPCPP 3575

Query: 350  MFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLL 409
             F+ + +  +  +G     E  +   P P + W + N+ +  +     ++  N G  T +
Sbjct: 3576 HFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPN-GSGTFI 3634

Query: 410  IKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRP 458
            + D  ++D+G Y   A N  G +TC   L V          P + +  P
Sbjct: 3635 VNDPQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDTPCKAKSTP 3683



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 60/254 (23%), Positives = 116/254 (45%), Gaps = 21/254 (8%)

Query: 191  GPQNAAAVFQAQDDS--GAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFY 248
            G  +A    + QD+S   +++ ++ +SE    +V T +++    + G +  +D       
Sbjct: 4192 GVASAVVSDEKQDESLKPSEEKEESSSESGTEEVATVKIQE---AEGGLIKEDG------ 4242

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P     + + +S +EG    +   ++   A +V+WY   + V SD+  K +  ++  ++L
Sbjct: 4243 PMIHTPLVDTVS-EEGDIVHLTTSITN--AKEVNWYFENKLVPSDEKFKCL-QDQNTYTL 4298

Query: 309  IFEVVRASD-AGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
            + + V   D  G Y C A N +G+   + +L V+    + AP+   K +  +V  G   K
Sbjct: 4299 VIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVV---KRAAPVIKRKIEPLEVALGHLAK 4355

Query: 368  LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
              C+I + P  +  W +    + + +D+ S+ + +    +L I      D G YT  A N
Sbjct: 4356 FTCEIQSAPNVRFQWFKAGREI-YESDKCSI-RSSKYISSLEILRTQVVDCGEYTCKASN 4413

Query: 428  EAGVTTCNTRLDVT 441
            E G  +C   L VT
Sbjct: 4414 EYGSVSCTATLTVT 4427



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 39/126 (30%), Positives = 64/126 (50%), Gaps = 1/126 (0%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
           PP F+Q  ++M++ +G   R+  +V+G+P P V +Y +G  +QS  L   I  E  L+SL
Sbjct: 103 PPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQS-SLDFQISQEGDLYSL 161

Query: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
           +       D+G Y+  A N  G AT T +L V  +E   A        + ++ E    ++
Sbjct: 162 LIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRI 221

Query: 369 ECQISA 374
           E +I A
Sbjct: 222 EKKIEA 227



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 57/260 (21%), Positives = 110/260 (42%), Gaps = 16/260 (6%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP+ +Q  + +++  G+  R    +SG P P +SWY   + + +    K +   +    L
Sbjct: 3192 PPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLL 3251

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKE--HKRAPMFIYKP------QSKKV 360
            + E     DA  Y C AKN  G AT +  L V   E       M +Y P      Q    
Sbjct: 3252 LIEAF-PEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVT 3310

Query: 361  LEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGW 420
             EG   + +C++S       ++ ++ ++      R++ ++D      L I +   +D G 
Sbjct: 3311 SEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDT---YQLEIAEAYPEDEGT 3367

Query: 421  YTVSAVNEAGVTTCNTRLDVTARP---NQTLPAPKQLRVRPTFSKYLALNGKGL-NVKQA 476
            YT  A N  G  +    L + A     ++ +    ++ ++   S +L+   +GL + +  
Sbjct: 3368 YTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKEFSSSFLSAEEEGLHSAELQ 3427

Query: 477  FNPEGEFQRLAAQSGLYESE 496
             +   E   L ++S +Y ++
Sbjct: 3428 LSKINETLELLSESPVYPTK 3447



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 52/176 (29%), Positives = 78/176 (44%), Gaps = 16/176 (9%)

Query: 280  DVSWYLNGRTV--QSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQ 337
            D  WY +G  +  Q  + HK +V E+ +H +     R SDAG Y  V    AG    +V 
Sbjct: 3130 DAHWYKDGIEINFQVQERHKYVV-ERRIHRMFISETRQSDAGEYTFV----AGRNRSSVT 3184

Query: 338  LDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRIS 397
            L V A E    P  + + Q   V  G   +    IS  P PK+ W +  +++  +T    
Sbjct: 3185 LYVNAPE---PPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLL--STGFKC 3239

Query: 398  LYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV----TARPNQTLP 449
             +  +    TLL+ +   +DA  YT  A N+ GV T +  L V       P+Q +P
Sbjct: 3240 KFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMP 3295



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 50/209 (23%), Positives = 84/209 (40%), Gaps = 30/209 (14%)

Query: 281   VSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
             V+WY   R +++ + ++ I  E G+  L  + +   D G Y C   N  GE +   +L V
Sbjct: 25103 VTWYFGVRQLENSEKYE-ITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFV 25161

Query: 341   LAKEH-----------------------KRAPMFIYKPQSKKVLEGDSVKLECQISAIPP 377
                                         +R P F     +K    G++V+    I+  P 
Sbjct: 25162 KGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPE 25221

Query: 378   PKLFWKRNNEMVQ-FNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
             P + W ++ + ++  + D+   ++ + G   L I  V   D   YTV A N+ G  +C  
Sbjct: 25222 PHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKA 25281

Query: 437   RLDVTARPNQTLPAPKQLRVRPTFSKYLA 465
             +L VT       P P    +RP F + LA
Sbjct: 25282 KLTVTLH-----PPPTDSTLRPMFKRLLA 25305



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 47/185 (25%), Positives = 87/185 (47%), Gaps = 8/185 (4%)

Query: 264   GRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYAC 323
             G   ++  ++ G P PD+ WY  G+ +     +KM  S+   H+L        D G Y C
Sbjct: 24050 GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKM-SSDGRTHTLTVMTEEQEDEGVYTC 24108

Query: 324   VAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWK 383
             +A N  GE   + +L +L    +  P +  K +    + G +++L       P P + W 
Sbjct: 24109 IATNEVGEVETSSKL-LLQATPQFHPGYPLKEKYYGAV-GSTLRLHVMYIGRPVPAMTWF 24166

Query: 384   RNNEMVQFNTDRISLYQDNTGRVT-LLIKDVNKK-DAGWYTVSAVNEAGVTTCNTRLDVT 441
                +++Q N++ I++  +NT   T L++K+V +K  AG Y V   N  G       +++ 
Sbjct: 24167 HGQKLLQ-NSENITI--ENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQ 24223

Query: 442   ARPNQ 446
              +P++
Sbjct: 24224 DKPDK 24228



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 36/117 (30%), Positives = 59/117 (50%), Gaps = 2/117 (1%)

Query: 324 VAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWK 383
           V   R  + T T ++    +     P  +   ++  V+EG+SV LEC IS  P P + W 
Sbjct: 872 VLHGREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWY 931

Query: 384 RNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
           R +  ++ + D    +Q    R  L+I++   +D+G +T SAVNEAG  + +  L V
Sbjct: 932 REDYQIESSIDFQITFQSGIAR--LMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV 986



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 62/264 (23%), Positives = 108/264 (40%), Gaps = 44/264 (16%)

Query: 235  GDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD 294
            GD+ D++  Q+ F+  +   +           CR+     G P   V W  +G+ +++ +
Sbjct: 1646 GDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLT--PIGDPTMVVEWLHDGKPLEAAN 1703

Query: 295  LHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAG----EATFTV-------------- 336
              +MI +E G  SL + V  + D+G   C A N+ G     AT  V              
Sbjct: 1704 RLRMI-NEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPE 1762

Query: 337  ---------QLDVLAKE-----------HKRAPMFIYKPQSKKVLEGDSVKLECQISAIP 376
                     +L+ +A E            K+ P  +  P+  +VLEG++ +  C+++  P
Sbjct: 1763 GRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYP 1822

Query: 377  PPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
             PK+ W  N ++++  + R  +  D  G   L I D    D G   V+A N  GV     
Sbjct: 1823 QPKVNWYLNGQLIR-KSKRFRVRYD--GIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKV 1879

Query: 437  RLDVTARPNQTLPAPKQLRVRPTF 460
            +L++  R +      +    RP F
Sbjct: 1880 KLEIQQREDFRSVLRRAPEPRPEF 1903



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 46/166 (27%), Positives = 79/166 (47%), Gaps = 13/166 (7%)

Query: 258  NMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASD 317
            N+ + E    ++  +VS  P  +V WY     +     ++ I++E     L+ +     D
Sbjct: 5974 NIEVSETDTIKLVCEVSK-PGAEVIWYKGDEEIIETGRYE-ILTEGRKRILVIQNAHLED 6031

Query: 318  AGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPP 377
            AG Y C   +         + D   K H+ A  FI KPQ+ ++LEG+  +  C IS    
Sbjct: 6032 AGNYNCRLPSS--------RTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESF 6083

Query: 378  PKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTV 423
            P + WKR+++ ++ + D+  +  D   RV L++KD   +D G Y V
Sbjct: 6084 P-VQWKRDDKTLE-SGDKYDVIADGKKRV-LVVKDATLQDMGTYVV 6126



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 1/125 (0%)

Query: 250   PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
             P FI  P + +I+EG+      ++SG P+P++ W+ N   + S   +  I   + ++SL 
Sbjct: 26637 PAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPI-SISSNVSISRSRNVYSLE 26695

Query: 310   FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLE 369
                   SD+G Y   AKN  G+ + T  L VL    + +   + +      L+G      
Sbjct: 26696 IRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQS 26755

Query: 370   CQISA 374
              Q+SA
Sbjct: 26756 VQMSA 26760



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 35/102 (34%), Positives = 50/102 (49%), Gaps = 3/102 (2%)

Query: 347 RAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV 406
           +AP F    QS  VLEG +   E  IS  P P++ W R+ +++  +T        + GR 
Sbjct: 4   QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63

Query: 407 TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV---TARPN 445
            L I  V K ++G Y++ A N +G  T    L V   TA PN
Sbjct: 64  KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPN 105



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 33/129 (25%), Positives = 63/129 (48%), Gaps = 8/129 (6%)

Query: 325  AKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSK----KVLEGDSVKLECQISAIPPPKL 380
            A N  GE+  ++ L+V+ ++ +  P    +   +    KV  G+ V +   ++ +P PK+
Sbjct: 8874 AVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKI 8933

Query: 381  FWKRNNEMVQFNTDRISLYQDNTGR----VTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
             W +N  +++  TD + + ++   R      L I    ++D G YTV+A N  G    N 
Sbjct: 8934 EWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNV 8993

Query: 437  RLDVTARPN 445
             ++V  RP+
Sbjct: 8994 HVEVYDRPS 9002



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 38/158 (24%), Positives = 66/158 (41%), Gaps = 4/158 (2%)

Query: 191  GPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPP 250
            G  + +A    +D+    +  Q       LQ    +   R    G +      Q++   P
Sbjct: 1738 GTDHTSATLIVKDEKSLVEESQLPEGRKGLQ--RIEELERMAHEGALTGVTTDQKEKQKP 1795

Query: 251  RFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
              +  PE + + EG   R   +V+G P P V+WYLNG+ ++     +  V   G+H L  
Sbjct: 1796 DIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKS--KRFRVRYDGIHYLDI 1853

Query: 311  EVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRA 348
               ++ D G     A+N  G     V+L++  +E  R+
Sbjct: 1854 VDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRS 1891



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 43/153 (28%), Positives = 68/153 (44%), Gaps = 11/153 (7%)

Query: 301  SEKGLHSLIFEVVRASDAGAYACVAK--NRAGEATFTVQLDVLAKEHKRAPMFIYKPQSK 358
            +++ +  L F V    + G Y    K  N AG +  +  +     +    P  I   +  
Sbjct: 9570 NKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFM 9629

Query: 359  KVLEGDSVKLECQISAIPPPKLFWKR-------NNEMVQFNTDRISLYQDNTGRVTLLIK 411
            +V EG +V +  +I  +P P L W +       N E V ++T    L  D+T   TL+I 
Sbjct: 9630 EVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDT--CTLVIP 9687

Query: 412  DVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARP 444
               + D G YT++AVN  G  +   RL+V  RP
Sbjct: 9688 QSRRSDTGLYTITAVNNLGTASKEMRLNVLGRP 9720



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 48/162 (29%), Positives = 72/162 (44%), Gaps = 11/162 (6%)

Query: 277  PAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTV 336
            P   V WY +G  V   D ++M  S++ +H L    +  SDA  Y+CV        T T 
Sbjct: 2155 PFVKVKWYKDGMEVHEGDKYRMH-SDRKVHFLSILTIDTSDAEDYSCVLVEDENVKT-TA 2212

Query: 337  QLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRI 396
            +L V          F+ + Q  +V E  S +LEC +S   P  +  K  +  V+  ++  
Sbjct: 2213 KLIV----EGAVVEFVKELQDIEVPESYSGELECIVS---PENIEGKWYHNDVELKSNGK 2265

Query: 397  SLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 438
                   GR  L +KDV K+D G Y  S V +   TTC  ++
Sbjct: 2266 YTITSRRGRQNLTVKDVTKEDQGEY--SFVIDGKKTTCKLKM 2305



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 40/147 (27%), Positives = 71/147 (48%), Gaps = 3/147 (2%)

Query: 299   IVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQ-LDVLAKEHKRAPMFIYKPQS 357
             IV+E  + + +   + +     +   A N  G++   V  + V+AK+    P       +
Sbjct: 17764 IVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNT 17823

Query: 358   KKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKD 417
               +  G+ +K+E  +   P P + W ++ E ++  T R+++ +  T  V L IK+ NK D
Sbjct: 17824 YSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLK-QTTRVNVEETATSTV-LHIKEGNKDD 17881

Query: 418   AGWYTVSAVNEAGVTTCNTRLDVTARP 444
              G YTV+A N AG  T N  + V  +P
Sbjct: 17882 FGKYTVTATNSAGTATENLSVIVLEKP 17908



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 32/143 (22%), Positives = 67/143 (46%), Gaps = 2/143 (1%)

Query: 307   SLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSV 366
             SL+   ++      +   A+N  G +       V   + +  P  I  P+   +  G  +
Sbjct: 12360 SLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKL 12419

Query: 367   KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAV 426
             ++E  +   P P   WK+  + V   +  +++++ ++  + L+IKDV +KD+G+Y+++A 
Sbjct: 12420 RIEAHVYGKPHPTCKWKKGEDEV-VTSSHLAVHKADSSSI-LIIKDVTRKDSGYYSLTAE 12477

Query: 427   NEAGVTTCNTRLDVTARPNQTLP 449
             N +G  T   ++ V   P    P
Sbjct: 12478 NSSGTDTQKIKVVVMDAPGPPQP 12500



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 33/153 (21%), Positives = 65/153 (42%), Gaps = 6/153 (3%)

Query: 198  VFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFY------PPR 251
            +F   +D G       N     +     ++ S+     D   + A+ +         PP 
Sbjct: 3517 LFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKLGGPCPPH 3576

Query: 252  FIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFE 311
            F++  + +   +G     ++ V G PAP V+W+   + + +   + +I +  G  + I  
Sbjct: 3577 FLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNGSGTFIVN 3636

Query: 312  VVRASDAGAYACVAKNRAGEATFTVQLDVLAKE 344
              +  D+G Y C A+N  GE+T   +L VL ++
Sbjct: 3637 DPQREDSGLYICKAENMLGESTCAAELLVLLED 3669



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 28/93 (30%), Positives = 46/93 (49%), Gaps = 1/93 (1%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKM-IVSEKGLHS 307
             PP+   +P ++SIDEG+   +    +G P P+V+W   GR + S +  +  I +   L +
Sbjct: 26831 PPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTT 26890

Query: 308   LIFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
             LI   V+  D G Y     N  G  + TV + +
Sbjct: 26891 LIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 26923



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 34/117 (29%), Positives = 55/117 (47%), Gaps = 5/117 (4%)

Query: 236  DVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDL 295
            D+++ +A++  F   R     +N  I EG       K+SG P P ++WY +G+ ++  + 
Sbjct: 1236 DISESEAVESGF-DSRI----KNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGER 1290

Query: 296  HKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFI 352
            ++M   + G  SL   VV   D G Y   A N  G A  + +L V       AP +I
Sbjct: 1291 YQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYI 1347



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 87/380 (22%), Positives = 135/380 (35%), Gaps = 93/380 (24%)

Query: 127  QPINAKPSQTAN-AKPIPRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQRLTYEEKM 185
            QP+  +  + A     I   P  +I   KE   Q L    KCK   LH+G +   Y   +
Sbjct: 3200 QPVTVQSGKPARFCAVISGRPQPKISWYKEE--QLLSTGFKCK--FLHDGQE---YTLLL 3252

Query: 186  ARRLLGPQNAAA-VFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQ 244
                  P++AA    +A++D G   +       A L V   +V S         DQ+   
Sbjct: 3253 IEAF--PEDAAVYTCEAKNDYGVATTS------ASLSVEVPEVVSP--------DQEM-- 3294

Query: 245  EKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG 304
               YPP  I   ++    EG+  R   +VSG     VSWY   + ++     +M   E  
Sbjct: 3295 -PVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQFEDT 3352

Query: 305  LHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKE---HKR-------------- 347
                I E     D G Y  VA N  G+ + T  L + A E   H+R              
Sbjct: 3353 YQLEIAEAY-PEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKEFSS 3411

Query: 348  -----------------------------APMFIYKPQSKK---------------VLEG 363
                                         +P++  K  S+K               +  G
Sbjct: 3412 SFLSAEEEGLHSAELQLSKINETLELLSESPVYPTKFDSEKEGTGPIFIKEVSNADISMG 3471

Query: 364  DSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTV 423
            D   L   +  IP PK+ W  N  ++  + D   ++  +    +L+I     +D G YT 
Sbjct: 3472 DVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDDH--SLIILFTKLEDEGEYTC 3529

Query: 424  SAVNEAGVTTCNTRLDVTAR 443
             A N+ G T C+  L + ++
Sbjct: 3530 MASNDYGKTICSAYLKINSK 3549



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 48/189 (25%), Positives = 83/189 (43%), Gaps = 14/189 (7%)

Query: 244  QEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVS---WYLNGRTVQSDDLHKMIV 300
            Q K  P +F++  +++ + E  F         L +P  +   W  +G  ++    H+ I 
Sbjct: 4612 QLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSPSTAITTWMKDGSNIRESPKHRFIA 4671

Query: 301  SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKK- 359
              K     I +V + SDAG Y CV +    E T T +L V     +  P+   K   ++ 
Sbjct: 4672 DGKDRKLHIIDV-QLSDAGEYTCVLRLGNKEKTSTAKLVV-----EELPVRFVKTLEEEV 4725

Query: 360  -VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
             V++G  + L C+++      + W+++ ++V     RI        R  L I D +  DA
Sbjct: 4726 TVVKGQPLYLSCELN--KERDVVWRKDGKIVVEKPGRIVPGVIGLMR-ALTINDADDTDA 4782

Query: 419  GWYTVSAVN 427
            G YTV+  N
Sbjct: 4783 GTYTVTVEN 4791



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 48/179 (26%), Positives = 73/179 (40%), Gaps = 14/179 (7%)

Query: 252  FIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFE 311
            FI  P+N+ I EG        +S    P V W  + +T++S D + +I   K    L+ +
Sbjct: 6057 FISKPQNLEILEGEKAEFVCSISKESFP-VQWKRDDKTLESGDKYDVIADGKK-RVLVVK 6114

Query: 312  VVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQ 371
                 D G Y  +     G A     L V+ K     P+     +  +V E   V   C+
Sbjct: 6115 DATLQDMGTYVVMV----GAARAAAHLTVIEKLRIVVPL-----KDTRVKEQQEVVFNCE 6165

Query: 372  ISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
            ++     K  W RN E +  ++  I L +D     TL I+D +  D   Y VS  N  G
Sbjct: 6166 VNT-EGAKAKWFRNEEAIFDSSKYIILQKDLV--YTLRIRDAHLDDQANYNVSLTNHRG 6221



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 34/133 (25%), Positives = 64/133 (48%), Gaps = 10/133 (7%)

Query: 251   RFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
             R +  P +M++ EG   R      G P P V+W   G+ + +   H++  ++   +   F
Sbjct: 26065 RILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTK---YKSTF 26121

Query: 311   EV--VRASDAGAYACVAKNRAG----EATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGD 364
             E+  V+ASD G Y+ V +N  G    E T T+Q   + ++   +P  +  P+  +V   +
Sbjct: 26122 EISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPE-PRVKSPE 26180

Query: 365   SVKLECQISAIPP 377
             +VK   ++ +  P
Sbjct: 26181 AVKSPKRVKSPEP 26193



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 45/200 (22%), Positives = 85/200 (42%), Gaps = 17/200 (8%)

Query: 256   PENMSI-DEGR------FCRMDFKVSGLPAPDVSWYLNGRTVQSDD---LHKMIVSEKGL 305
             PEN+ I D+G+      + R D+      +P++S+++  R   SDD   +HK  + E   
Sbjct: 11607 PENLHIADKGKTFVYLKWRRPDYDGG---SPNLSYHVERRLKGSDDWERVHKGSIKET-- 11661

Query: 306   HSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE-GD 364
             H ++   V  +    +    KN  GE+ +    +V+ KE  + P+   K      ++ GD
Sbjct: 11662 HYMVDRCVE-NQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGD 11720

Query: 365   SVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVS 424
             +++LE  +   P P++ W ++ +                      +    + D G Y V+
Sbjct: 11721 TIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVT 11780

Query: 425   AVNEAGVTTCNTRLDVTARP 444
             A N AG       ++V  +P
Sbjct: 11781 ATNTAGSFVAYATVNVLDKP 11800



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 50/182 (27%), Positives = 83/182 (45%), Gaps = 21/182 (11%)

Query: 257  ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG-LHSLIFEVVRA 315
            +++++  G     D ++S    P V WYL G+ ++  D  K++   +G +H+L    V+ 
Sbjct: 5706 KDVTVTAGETATFDCELSYEDIP-VEWYLKGKKLEPSD--KVVPRSEGKVHTLTLRDVKL 5762

Query: 316  SDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKP-QSKKVLEGDSVKLECQISA 374
             DAG     AK+    A   V         K  P+   KP + + V EG +  LEC++S 
Sbjct: 5763 EDAGEVQLTAKDFKTHANLFV---------KEPPVEFTKPLEDQTVEEGATAVLECEVSR 5813

Query: 375  IPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV-TLLIKDVNKKDAGWYTVSAVNEAGVTT 433
                K+ W +N   +   + +  +  D  GRV  L+I D   +D   YT  A +    T+
Sbjct: 5814 -ENAKVKWFKNGTEI-LKSKKYEIVAD--GRVRKLVIHDCTPEDIKTYTCDAKDFK--TS 5867

Query: 434  CN 435
            CN
Sbjct: 5868 CN 5869



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 33/111 (29%), Positives = 55/111 (49%), Gaps = 8/111 (7%)

Query: 235   GDVNDQDAIQEKFYPPRF---IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTV- 290
             G+V D   ++++   P       V + + +  G   R+   VSG P P V+W +N RT+ 
Sbjct: 10010 GEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLP 10069

Query: 291   QSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
             Q   +    +S     S++ +  + S  G Y+ +AKN AGE   T+ +DVL
Sbjct: 10070 QEATIETTAISS----SMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVL 10116



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 62/269 (23%), Positives = 101/269 (37%), Gaps = 46/269 (17%)

Query: 166  KCKDTLLHNGNQRLTYEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTS 225
            K KD LLH   + LT EEK A                            +E  ++ +PT 
Sbjct: 1987 KTKDELLH-WTKELTEEEKKAL---------------------------AEEGKITIPTF 2018

Query: 226  QVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYL 285
            +            D+  +      P+  +  ++ ++ +G       +V G P P+  WY 
Sbjct: 2019 KP-----------DKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYK 2067

Query: 286  NGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEH 345
            NG  ++  D       E  +  L+   V A D+ +    A N AGE +    L V AK+ 
Sbjct: 2068 NGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQ- 2126

Query: 346  KRAPMFIYKPQSKKVLEGDSV-KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTG 404
                 F  + Q     E D++   EC+ S  P  K+ W ++  M     D+  ++ D   
Sbjct: 2127 --LITFTQELQDVVAKEKDTMATFECETSE-PFVKVKWYKDG-MEVHEGDKYRMHSDRKV 2182

Query: 405  RVTLLIKDVNKKDAGWYTVSAVNEAGVTT 433
               L I  ++  DA  Y+   V +  V T
Sbjct: 2183 HF-LSILTIDTSDAEDYSCVLVEDENVKT 2210



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 32/114 (28%), Positives = 56/114 (49%), Gaps = 3/114 (2%)

Query: 359  KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
            ++LEG  V   C++S  P PK+ W ++ + ++ + +R  +     GR +L I  V  +D 
Sbjct: 1255 RILEGMGVTFHCKMSGYPLPKIAWYKDGKRIK-HGERYQMDFLQDGRASLRIPVVLPEDE 1313

Query: 419  GWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLN 472
            G YT  A N  G   C+ +L V   P   L AP  +      S+  +L+ + ++
Sbjct: 1314 GIYTAFASNIKGNAICSGKLYV--EPAAPLGAPTYIPTLEPVSRIRSLSPRSVS 1365



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 30/82 (36%), Positives = 42/82 (51%), Gaps = 2/82 (2%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G    ++  IS  P PK+ WK   EM    TDR+S+      R TL +KD  + D+G Y 
Sbjct: 22165 GSPFTIDVPISGRPAPKVTWKLE-EMRLKETDRVSI-TTTKDRTTLTVKDSMRGDSGRYF 22222

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             ++  N AGV T +  + V  RP
Sbjct: 22223 LTLENTAGVKTFSVTVVVIGRP 22244



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 42/141 (29%), Positives = 74/141 (52%), Gaps = 14/141 (9%)

Query: 283  WYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLA 342
            WY N   ++S+  +  I S +G  +L  + V   D G Y+ V   +  + T  +++    
Sbjct: 2253 WYHNDVELKSNGKYT-ITSRRGRQNLTVKDVTKEDQGEYSFVIDGK--KTTCKLKM---- 2305

Query: 343  KEHKRAPMFIYKPQS-KKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQD 401
               K  P+ I +  S +KV EGD V+LE ++S +   +  W ++ + VQ  +DR+ +  D
Sbjct: 2306 ---KPRPIAILQGLSDQKVCEGDIVQLEVKVS-LESVEGVWMKDGQEVQ-PSDRVHIVID 2360

Query: 402  NTGRVTLLIKDVNKKDAGWYT 422
                + LLI+D+ K+DAG Y+
Sbjct: 2361 KQSHM-LLIEDMTKEDAGNYS 2380



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 41/178 (23%), Positives = 79/178 (44%), Gaps = 15/178 (8%)

Query: 251  RFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
            + I+ P++++  E      +  VS    P V W+     ++  D H++ VSE+ +H L+ 
Sbjct: 2750 KIIKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKSVEIKPSDKHRL-VSERKVHKLML 2807

Query: 311  EVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLEC 370
            + +  SDAG Y  V      +A   V+   + K  K     I  P++K      +   EC
Sbjct: 2808 QNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKN----IEVPETK------TASFEC 2857

Query: 371  QISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            ++S    P + W +N   ++ +     + Q    +  L+I + + +D+  YT    N+
Sbjct: 2858 EVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQ--LIIMNTSTEDSAEYTFVCGND 2912



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 40/148 (27%), Positives = 68/148 (45%), Gaps = 12/148 (8%)

Query: 225   SQVRSRSTSRGDVN--------DQDAIQEKFYPPRF---IQVPENMSIDEGRFCRMDFKV 273
             +Q + R+ +R  VN        D   I  +  PPR    + +   +++  G    +D  V
Sbjct: 12763 AQYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATV 12822

Query: 274   SGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEAT 333
              G P P VSW  +G  ++  +  KM + ++ L +L    V   D+G Y   A+N +G  +
Sbjct: 12823 FGKPMPTVSWKKDGTLLKPAEGIKMAM-QRNLCTLELFSVNRKDSGDYTITAENSSGSKS 12881

Query: 334   FTVQLDVLAKEHKRAPMFIYKPQSKKVL 361
              T++L VL K    A + I K  S + +
Sbjct: 12882 ATIKLKVLDKPGPPASVKINKMYSDRAM 12909



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 34/123 (27%), Positives = 59/123 (47%), Gaps = 6/123 (4%)

Query: 325   AKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAIPPPKLF 381
             A+N  GE T + ++ V+A++   AP    K          E  + +L+  I   P P + 
Sbjct: 13460 AENENGEGTPS-EITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVS 13518

Query: 382   WKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVT 441
             WK+  + +  +T R+S+ + +    TL++ D  K DAG YT++  N AG       + V 
Sbjct: 13519 WKKGEDPLATDT-RVSV-ESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVV 13576

Query: 442   ARP 444
              +P
Sbjct: 13577 GKP 13579



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 49/180 (27%), Positives = 84/180 (46%), Gaps = 25/180 (13%)

Query: 250  PRFIQVPENMS---IDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQ-SDDLHKMIVSEKGL 305
            PR I + + +S   + EG   +++ KVS L + +  W  +G+ VQ SD +H  IV +K  
Sbjct: 2307 PRPIAILQGLSDQKVCEGDIVQLEVKVS-LESVEGVWMKDGQEVQPSDRVH--IVIDKQS 2363

Query: 306  HSLIFEVVRASDAGAYA----CVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL 361
            H L+ E +   DAG Y+     +  + +G  +    +DV+       P+     +   V+
Sbjct: 2364 HMLLIEDMTKEDAGNYSFTIPALGLSTSGRVS-VYSVDVIT------PL-----KDVNVI 2411

Query: 362  EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWY 421
            EG    LEC++S      + W  N+E ++   DR+      T +  L+I   +  D G Y
Sbjct: 2412 EGTKAVLECKVSVPDVTSVKWYLNDEQIK-PDDRVQAIVKGT-KQRLVINRTHASDEGPY 2469



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 28/96 (29%), Positives = 46/96 (47%), Gaps = 1/96 (1%)

Query: 348  APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
            AP    + QS+ V +G       ++   P P+  W +N   ++  +DRI  Y        
Sbjct: 2031 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIE-RSDRIYWYWPEDNVCE 2089

Query: 408  LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTAR 443
            L+I+DV  +D+    V A+N AG T+ +  L V A+
Sbjct: 2090 LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAK 2125



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 41/174 (23%), Positives = 71/174 (40%), Gaps = 19/174 (10%)

Query: 263  EGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYA 322
            EG    +      +P P VSW+ +G+ V++ D   M       H  + + VRA DAG Y 
Sbjct: 7903 EGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRA-DAGIYT 7961

Query: 323  CVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPP----- 377
               +N+ G AT ++ + V+                K +   D  K  C+++  PP     
Sbjct: 7962 ITLENKLGSATASINVKVIG----------LPGPCKDIKASDITKSSCKLTWEPPEFDGG 8011

Query: 378  -PKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
             P L +          T    +  +N  +++  +KD+      ++ V AVN+ G
Sbjct: 8012 TPILHYVLERREAGRRTYIPVMSGEN--KLSWTVKDLIPNGEYFFRVKAVNKVG 8063



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 24/86 (27%), Positives = 45/86 (52%), Gaps = 2/86 (2%)

Query: 359   KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
             K   G SVKL   IS  P P + W ++++ +Q  T+ +   ++ T   ++LIKD ++ ++
Sbjct: 20386 KYRAGTSVKLRAGISGKPAPTIEWYKDDKELQ--TNALVCVENTTDLASILIKDADRLNS 20443

Query: 419   GWYTVSAVNEAGVTTCNTRLDVTARP 444
             G Y +   N  G  +   R+ +  +P
Sbjct: 20444 GCYELKLRNAMGSASATIRVQILDKP 20469



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 52/193 (26%), Positives = 79/193 (40%), Gaps = 18/193 (9%)

Query: 251  RFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
            +F+   E+ ++ EG       ++S      V W+ N   + +     +I SE   H L  
Sbjct: 5078 KFMSPLEDQTVKEGETATFVCELSH-EKMHVVWFKNDAKLHTSRT-VLISSEGKTHKLEM 5135

Query: 311  EVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLEC 370
            + V   D        K    E + T QL VL  +    P F  K   K  +E D + L+C
Sbjct: 5136 KEVTLDDISQIKAQVK----ELSSTAQLKVLEAD----PYFTVKLHDKTAVEKDEITLKC 5187

Query: 371  QISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
            ++S   P K F K   E+V   + + S+  D   R+ L IK  + KD G Y    V + G
Sbjct: 5188 EVSKDVPVKWF-KDGEEIVP--SPKYSIKADGLRRI-LKIKKADLKDKGEY----VCDCG 5239

Query: 431  VTTCNTRLDVTAR 443
                   + V AR
Sbjct: 5240 TDKTKANVTVEAR 5252



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 27/101 (26%), Positives = 43/101 (42%), Gaps = 4/101 (3%)

Query: 244   QEKFYPPRF---IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIV 300
             QEK  PP     +++ E + +  G   R    + G+P P   W  +G  +++D+ H  + 
Sbjct: 11005 QEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDE-HYTVE 11063

Query: 301   SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
             ++     L  +     D G Y     N AG  T  V L VL
Sbjct: 11064 TDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVL 11104



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 36/144 (25%), Positives = 67/144 (46%), Gaps = 4/144 (2%)

Query: 303   KGLHSLIFEVVRASDAGAYACVAKNRAGEAT-FTVQLDVLAKEHKRAPMFIYKPQSKKVL 361
             K L ++I  + +  +   +  VA N  G +   ++ + ++AK+    P       S  V 
Sbjct: 16687 KSLQAVITNLTQGEEY-LFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQ 16745

Query: 362   EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWY 421
              G  +K+E  IS  P P + W ++   ++  T RI++  D+    TL IK+ +K D G Y
Sbjct: 16746 VGQDLKIEVPISGRPKPTITWTKDGLPLK-QTTRINV-TDSLDLTTLSIKETHKDDGGQY 16803

Query: 422   TVSAVNEAGVTTCNTRLDVTARPN 445
              ++  N  G  T +  +    +P+
Sbjct: 16804 GITVANVVGQKTASIEIVTLDKPD 16827



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 27/106 (25%), Positives = 53/106 (50%), Gaps = 2/106 (1%)

Query: 339  DVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISL 398
            +V+AK+    P    +     V+EG+ + +     A+P P + W ++ + V+  +DR+++
Sbjct: 7880 NVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVK-ASDRLTM 7938

Query: 399  YQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARP 444
              D+      + K V + DAG YT++  N+ G  T +  + V   P
Sbjct: 7939 KNDHISAHLEVPKSV-RADAGIYTITLENKLGSATASINVKVIGLP 7983



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 44/180 (24%), Positives = 77/180 (42%), Gaps = 19/180 (10%)

Query: 321   YACVAKNRAGEATFTVQLD----VLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQIS 373
             +  +A+N AG   F+   D    + A++   AP     P+ K V+    G++  LE  I 
Sbjct: 18178 FRVIARNAAGN--FSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIR 18235

Query: 374   AIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTT 433
               P P + W ++ + ++    R+ + +    + TL++KD  + D G Y +   N  G  +
Sbjct: 18236 GKPIPDVVWSKDGKELEETAARMEI-KSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKS 18294

Query: 434   CNTRLDVTARPNQTLPAPKQLRVRPTFSK--YLA----LNGKGLNVKQAFNPEGEFQRLA 487
                 + V  RP    P    L+V    ++  YLA    L   G N+      + E  RL+
Sbjct: 18295 IPITVKVLDRPG---PPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLS 18351



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 51/200 (25%), Positives = 85/200 (42%), Gaps = 25/200 (12%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P  F++  E+ ++ E        ++S   A +V WY NGR ++    +K    +  +H L
Sbjct: 6325 PTEFVEHLEDQTVTEFDDAVFSCQLSREKA-NVKWYRNGREIKEGKKYKF-EKDGSIHRL 6382

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL---EGDS 365
            I +  R  D   YAC  ++R   A   V  + +  E  R P  I +     V+   E + 
Sbjct: 6383 IIKDCRLDDECEYACGVEDRKSRARLFV--EEIPVEIIRPPQDILEAPGADVVFLAELNK 6440

Query: 366  VKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV-TLLIKDVNKKDAGWYTVS 424
             K+E Q          W RNN MV    D+  +  +  G++  L I D+  +D G Y   
Sbjct: 6441 DKVEVQ----------WLRNN-MVVVQGDKHQMMSE--GKIHRLQICDIKPRDQGEYRFI 6487

Query: 425  AVNEAGVTTCNTRLDVTARP 444
            A ++        +L++ A P
Sbjct: 6488 AKDK----EARAKLELAAAP 6503



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 32/135 (23%), Positives = 64/135 (47%), Gaps = 6/135 (4%)

Query: 299   IVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSK 358
             I + KGL  ++  +    +   +  +A N AG +       V+ KE    P    +   +
Sbjct: 14517 ITTVKGLECVVRNLTEGEEY-TFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQ 14575

Query: 359   KVL---EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNK 415
             K++    GD++K+E  +   P P + WK+ +++++  T R++     T  + L I +  +
Sbjct: 14576 KLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILK-QTQRVNFETTATSTI-LNINECVR 14633

Query: 416   KDAGWYTVSAVNEAG 430
              D+G Y ++A N  G
Sbjct: 14634 SDSGPYPLTARNIVG 14648



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 29/102 (28%), Positives = 50/102 (49%), Gaps = 10/102 (9%)

Query: 250  PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYL-------NGRTVQSD-DLHKMIVS 301
            P  I + E M ++EG    +  K+ G+P P ++W+        N   V  D  ++K++V 
Sbjct: 9620 PPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVD 9679

Query: 302  EKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
            +    +L+    R SD G Y   A N  G A+  ++L+VL +
Sbjct: 9680 D--TCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGR 9719



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 34/128 (26%), Positives = 56/128 (43%), Gaps = 8/128 (6%)

Query: 325  AKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSK---KVLEGDSVKLECQISAIPPPKLF 381
            A N AGE        V   E +  P        K   +++ G ++++   ++  P P   
Sbjct: 8581 AVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKV 8640

Query: 382  WKRNNEMVQFNTDRISLYQDNTG-RVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
            W +  E  + + DR+ +  DN G +  L+IKD  +KD G Y ++A N  G      R++V
Sbjct: 8641 WTK--EEGELDKDRVVI--DNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEV 8696

Query: 441  TARPNQTL 448
               P   L
Sbjct: 8697 FDVPGPVL 8704



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 52/193 (26%), Positives = 78/193 (40%), Gaps = 23/193 (11%)

Query: 277   PAPDVSWYLNGRTVQSDDLHK---MIVSEKGLHSLIFEVVRASDAGAYA--CVAKNRAG- 330
             P  D    L G  V+  DL     M  +   +    F V    + G Y     AKN AG 
Sbjct: 13800 PKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGA 13859

Query: 331   -----EATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE---GDSVKLEC-QISAIPPPKLF 381
                  E+T T+    + K+   AP  +  P  K  L    GD++ L    I   P PK  
Sbjct: 13860 ISAPSESTETI----ICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSS 13915

Query: 382   WKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVT 441
             W +  + ++  +D   +    T  + L IK   +KDAG YT++A N  G    + ++ V 
Sbjct: 13916 WSKAGKDIR-PSDITQITSTPTSSM-LTIKYATRKDAGEYTITATNPFGTKVEHVKVTVL 13973

Query: 442   ARPNQTLPAPKQL 454
               P    P P ++
Sbjct: 13974 DVPGP--PGPVEI 13984



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 28/99 (28%), Positives = 46/99 (46%), Gaps = 2/99 (2%)

Query: 243   IQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSE 302
             +  K + P+ ++    +    G    +    SG P P ++W   G+ +  ++ H  ++  
Sbjct: 24524 VPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQ-KGQDLIDNNGHYQVIVT 24582

Query: 303   KGLHSLIF-EVVRASDAGAYACVAKNRAGEATFTVQLDV 340
             +   SL+F   V   DAG Y   AKNR G    TV+LDV
Sbjct: 24583 RSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDV 24621



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 40/169 (23%), Positives = 63/169 (37%), Gaps = 8/169 (4%)

Query: 178  RLTYEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDV 237
            R  + E   R      N A           Q S++   E   +    +    R     DV
Sbjct: 957  REAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDV 1016

Query: 238  --NDQDAIQEKFYP-----PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTV 290
               D    +E+  P     P FI  P    + EG       +V G P P V W  +G  +
Sbjct: 1017 VMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPL 1076

Query: 291  QSDDLHKMIVSEK-GLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQL 338
             +   +K+  +++ G   L+  +  A DAG Y  V +N+ GE + +  L
Sbjct: 1077 TTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 28/108 (25%), Positives = 48/108 (44%), Gaps = 2/108 (1%)

Query: 244   QEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEK 303
             +E+  PP+ + +PE ++I  G+  R++  V G P P   W   G        H  +    
Sbjct: 12397 KEQLLPPKIL-MPEQITIKAGKKLRIEAHVYGKPHPTCKW-KKGEDEVVTSSHLAVHKAD 12454

Query: 304   GLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMF 351
                 LI + V   D+G Y+  A+N +G  T  +++ V+       P F
Sbjct: 12455 SSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPF 12502



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 27/102 (26%), Positives = 49/102 (48%), Gaps = 6/102 (5%)

Query: 360   VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
             V  G +V L+  +   P P + WK++  +++         Q N    TL +  VN+KD+G
Sbjct: 12810 VKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNL--CTLELFSVNRKDSG 12867

Query: 420   WYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFS 461
              YT++A N +G  +   +L V  +P      P  +++   +S
Sbjct: 12868 DYTITAENSSGSKSATIKLKVLDKPG----PPASVKINKMYS 12905



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 39/150 (26%), Positives = 63/150 (42%), Gaps = 17/150 (11%)

Query: 231   STSRGDVNDQDAIQEKFYPPRFIQVP---ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNG 287
             S S G +  +D +     PPR    P   + + +  G   ++D  + G P P + W + G
Sbjct: 16029 SESTGAITARDEVD----PPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQW-IKG 16083

Query: 288   RTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKR 347
                 S+     I S     SL  +     D+G Y   AKN AGE + TV + VL +    
Sbjct: 16084 DQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPG-- 16141

Query: 348   APMFIYKPQSKKVLEGDSVKLECQISAIPP 377
                    P+   V+ G + + +C ++  PP
Sbjct: 16142 ------PPEGPVVISGVTAE-KCTLAWKPP 16164



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 21/86 (24%), Positives = 36/86 (41%)

Query: 355   PQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVN 414
             P    + EG  + + C  +  P P++ W      +          ++     TL+I DV 
Sbjct: 26838 PSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQ 26897

Query: 415   KKDAGWYTVSAVNEAGVTTCNTRLDV 440
             K+D G YT+S  NE G  +    + +
Sbjct: 26898 KQDGGLYTLSLGNEFGSDSATVNIHI 26923



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 42/204 (20%), Positives = 72/204 (35%), Gaps = 37/204 (18%)

Query: 274   SGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAG--- 330
             S L A +V+WY +G+ ++ +   +   S  G + L    +  SD G Y C      G   
Sbjct: 26245 SVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSK 26304

Query: 331   -------------------------------EATFTVQLDVLAKEH-KRAPMFIYKPQSK 358
                                            E+T T + +  A E     P+ +   Q  
Sbjct: 26305 TNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDT 26364

Query: 359   KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
              V      K   + +  P P   W ++ + +     +  L +D  G   L I   +  D+
Sbjct: 26365 TVSSDSVAKFAVKATGEPRPTAIWTKDGKAIT-QGGKYKLSEDK-GGFFLEIHKTDTSDS 26422

Query: 419   GWYTVSAVNEAGVTTCNTRLDVTA 442
             G YT +  N AG  + + +L + A
Sbjct: 26423 GLYTCTVKNSAGSVSSSCKLTIKA 26446



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 30/129 (23%), Positives = 60/129 (46%), Gaps = 7/129 (5%)

Query: 321   YACVAKNRAGEATFTVQLD--VLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAI 375
             +  +AKN AG  +   +    +  ++   AP      + K  +    G++ +LE  +S  
Sbjct: 14932 FRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGR 14991

Query: 376   PPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCN 435
             PPP + W ++ + ++  T ++ +   +     L+ KD  ++D+G YT++A N  G     
Sbjct: 14992 PPPTMEWSKDGKELE-GTAKLEIKIADFS-TNLVNKDSTRRDSGAYTLTATNPGGFAKHI 15049

Query: 436   TRLDVTARP 444
               + V  RP
Sbjct: 15050 FNVKVLDRP 15058



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 26/95 (27%), Positives = 45/95 (47%), Gaps = 2/95 (2%)

Query: 336   VQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDR 395
             + + V+AK+    P F     +  VL G+ +K++      P P + W ++N  ++  T R
Sbjct: 15638 LSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLK-QTTR 15696

Query: 396   ISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
             ++  +       L IKD  ++D G Y V   N AG
Sbjct: 15697 VNA-ESTENNSLLTIKDACREDVGHYVVKLTNSAG 15730



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 21/86 (24%), Positives = 38/86 (44%), Gaps = 1/86 (1%)

Query: 257   ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRAS 316
             ++ ++      +   K +G P P   W  +G+ +     +K+   +KG   L       S
Sbjct: 26362 QDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLS-EDKGGFFLEIHKTDTS 26420

Query: 317   DAGAYACVAKNRAGEATFTVQLDVLA 342
             D+G Y C  KN AG  + + +L + A
Sbjct: 26421 DSGLYTCTVKNSAGSVSSSCKLTIKA 26446



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 39/163 (23%), Positives = 66/163 (40%), Gaps = 16/163 (9%)

Query: 281  VSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
            V W+ N + + +     M   E   HS+ F+ +   D       A   + EA  TV    
Sbjct: 5462 VKWFKNDQRLHTTRSVSM-QDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVL--- 5517

Query: 341  LAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQ 400
                 +  P F  K Q    +E D V L+C+IS    P  ++K   E+      + ++ +
Sbjct: 5518 -----EGDPYFTGKLQDYTGVEKDEVILQCEISKADAPVKWFKDGKEI---KPSKNAVIK 5569

Query: 401  DNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTAR 443
             +  +  L++K   K D G YT     + G    + +LD+  R
Sbjct: 5570 ADGKKRMLILKKALKSDIGQYTC----DCGTDKTSGKLDIEDR 5608



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 32/142 (22%), Positives = 62/142 (43%), Gaps = 14/142 (9%)

Query: 306   HSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL---E 362
             H   F V+  + AG ++  +++            + A++    P     P+ K  +    
Sbjct: 16010 HRYEFRVIARNAAGVFSEPSESTGA---------ITARDEVDPPRISMDPKYKDTIVVHA 16060

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G+S K++  I   P P + W + ++ +  NT R+ +   +    +L +KD  + D+G Y 
Sbjct: 16061 GESFKVDADIYGKPIPTIQWIKGDQELS-NTARLEIKSTDFA-TSLSVKDAVRVDSGNYI 16118

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             + A N AG  +    + V  RP
Sbjct: 16119 LKAKNVAGERSVTVNVKVLDRP 16140



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 30/129 (23%), Positives = 58/129 (44%), Gaps = 7/129 (5%)

Query: 321   YACVAKNRAGEATFTVQLD--VLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAI 375
             +  +AKN AG  +        + AK+    P     P+ +  +    G++ +LE  +   
Sbjct: 17096 FRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGK 17155

Query: 376   PPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCN 435
             P P + W R ++ ++  + R  + ++   +  L++KD  + D G Y + A N AG  +  
Sbjct: 17156 PLPTIEWLRGDKEIE-ESARCEI-KNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFP 17213

Query: 436   TRLDVTARP 444
               + V  RP
Sbjct: 17214 VNVKVLDRP 17222



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 24/98 (24%), Positives = 41/98 (41%)

Query: 250   PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
             P F ++  N    EG+    + +VSG+P P + W  +G+ +      ++I      ++L 
Sbjct: 25298 PMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALH 25357

Query: 310   FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKR 347
                    D G Y   A N AG  +    L V    +K+
Sbjct: 25358 IRDTLPEDTGYYRVTATNTAGSTSCQAHLQVERLRYKK 25395



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 40/158 (25%), Positives = 61/158 (38%), Gaps = 13/158 (8%)

Query: 277  PAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTV 336
            P   V W  + + +Q  D  K I  EK +H L+    R SDAG Y  VA      A   V
Sbjct: 3038 PDITVQWMKDDQELQITDRIK-IQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFV 3096

Query: 337  Q-LDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDR 395
            +  DV  +  K+    I K ++    E +   ++            W ++   + F    
Sbjct: 3097 EGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAH----------WYKDGIEINFQVQE 3146

Query: 396  ISLYQDNTGRVTLLIKDVNKKDAGWYT-VSAVNEAGVT 432
               Y        + I +  + DAG YT V+  N + VT
Sbjct: 3147 RHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVT 3184



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 23/82 (28%), Positives = 42/82 (51%), Gaps = 2/82 (2%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G ++++  ++   P P + W +  +++     R+ L QD   RV L IK+  + D G Y 
Sbjct: 11426 GQTIRILARVKGRPEPDITWTKEGKVL-VREKRVDLIQD-LPRVELQIKEAVRADHGKYI 11483

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             +SA N +G    +  ++V  RP
Sbjct: 11484 ISAKNSSGHAQGSAIVNVLDRP 11505



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)

Query: 268   RMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKN 327
             R+   + G PAP VSW   G    + D    + S     +LI    + SDAG Y    KN
Sbjct: 13504 RLKIPIKGKPAPSVSWK-KGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKN 13562

Query: 328   RAGEATFTVQLDVLAK 343
              AG    T+ + V+ K
Sbjct: 13563 VAGTKEGTISIKVVGK 13578



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 21/91 (23%), Positives = 46/91 (50%), Gaps = 1/91 (1%)

Query: 253   IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEV 312
             ++  E +    G   ++   +SG PAP + WY + + +Q++ L   + +   L S++ + 
Sbjct: 20379 LEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNAL-VCVENTTDLASILIKD 20437

Query: 313   VRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
                 ++G Y    +N  G A+ T+++ +L K
Sbjct: 20438 ADRLNSGCYELKLRNAMGSASATIRVQILDK 20468



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 6/83 (7%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKD-VNKKDAGWY 421
             G S++L   +S  PPP + W +    +   +  I    D T   +LLI D VN+ DAG Y
Sbjct: 22964 GASLRLMVSVSGRPPPVITWSKQG--IDLASRAII---DTTESYSLLIVDKVNRYDAGKY 23018

Query: 422   TVSAVNEAGVTTCNTRLDVTARP 444
             T+ A N++G  +    + V   P
Sbjct: 23019 TIEAENQSGKKSATVLVKVYDTP 23041



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 23/85 (27%), Positives = 42/85 (49%), Gaps = 2/85 (2%)

Query: 360  VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
            V  G  ++L   ++  P PK+ W +  +M+     RI++ ++   + T+ I D  + D G
Sbjct: 7205 VKAGTKIELPATVTGKPEPKITWTKA-DMILKQDKRITI-ENVPKKSTVTIVDSKRSDTG 7262

Query: 420  WYTVSAVNEAGVTTCNTRLDVTARP 444
             Y + AVN  G  T    ++V  +P
Sbjct: 7263 TYIIEAVNVCGRATAVVEVNVLDKP 7287



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 36/140 (25%), Positives = 63/140 (45%), Gaps = 12/140 (8%)

Query: 321   YACVAKNRAGEATFT-VQLDVLAKEHKRAPMFIYKP---QSKKVLEGDSVKLECQISAIP 376
             +  +A N AGE+    V   VL K+    P  I      + + +  GD+++L   I  +P
Sbjct: 10690 FRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVP 10749

Query: 377   PPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
              PK+ WK+ +        RI +    +    L I++   +D G Y+++  N AG  T + 
Sbjct: 10750 FPKVTWKKEDRDAPTKA-RIDVTPVGS---KLEIRNAAHEDGGIYSLTVENPAGSKTVSV 10805

Query: 437   RLDVTARPNQTLPAPKQLRV 456
             ++ V  +P      P+ L V
Sbjct: 10806 KVLVLDKPG----PPRDLEV 10821



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 37/128 (28%), Positives = 62/128 (48%), Gaps = 14/128 (10%)

Query: 325   AKNRAGEAT-FTVQLDVLAKEHKRAP---MFIYKPQSKKVLEGDSVKLECQISAIPPPKL 380
             A+N+AG +    + L VL KE    P   M  +   +  V  G ++K++  IS  P PK+
Sbjct: 19952 AENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKV 20011

Query: 381   FWKRNN----EMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
                R+       ++FNT+   +  +N   +T+ +K+    DAG Y ++A N +G T    
Sbjct: 20012 TLSRDGVPLKATMRFNTE---ITAEN---LTINLKESVTADAGRYEITAANSSGTTKAFI 20065

Query: 437   RLDVTARP 444
              + V  RP
Sbjct: 20066 NIVVLDRP 20073



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 25/83 (30%), Positives = 42/83 (50%), Gaps = 1/83 (1%)

Query: 259   MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDA 318
             +++  G+  R+  +V G P PD++W   G+ +  +    +I     +   I E VRA D 
Sbjct: 11421 ITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRA-DH 11479

Query: 319   GAYACVAKNRAGEATFTVQLDVL 341
             G Y   AKN +G A  +  ++VL
Sbjct: 11480 GKYIISAKNSSGHAQGSAIVNVL 11502



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 56/245 (22%), Positives = 99/245 (40%), Gaps = 21/245 (8%)

Query: 106   DYNSSKIPSAMDSN---YQQSSAGQPINAKPSQ-TANAKPI--PRTPDHEIQGSKEALIQ 159
             +Y ++ +   +D     Y ++SAG    + PS+ T    P+  P TPD+ I  ++E +  
Sbjct: 21318 EYRATGLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDY-IDVTRETIT- 21375

Query: 160   DLERKLKCKDTLLHNGNQRLTY--EEKMARRLLGPQNAAAVFQAQDD-SGAQDSQQHNSE 216
                  LK    L   G++ + Y  E++         N   V + Q   +G     ++   
Sbjct: 21376 -----LKWNPPLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFR 21430

Query: 217   H-ARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSG 275
               AR  V T    S+S+      D++      + P +    + + I  G   R+   V G
Sbjct: 21431 IIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYF---DGLIIKSGESLRIKALVQG 21487

Query: 276   LPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFT 335
              P P V+W+ +G  ++   ++  I    G  SL          G Y   AKN +G A   
Sbjct: 21488 RPVPRVTWFKDGVEIEK-RMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAE 21546

Query: 336   VQLDV 340
             +++ V
Sbjct: 21547 IKVKV 21551



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 23/75 (30%), Positives = 37/75 (49%), Gaps = 1/75 (1%)

Query: 269   MDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNR 328
             +D  +SG PAP V+W L    ++  D    I + K   +L  +     D+G Y    +N 
Sbjct: 22170 IDVPISGRPAPKVTWKLEEMRLKETD-RVSITTTKDRTTLTVKDSMRGDSGRYFLTLENT 22228

Query: 329   AGEATFTVQLDVLAK 343
             AG  TF+V + V+ +
Sbjct: 22229 AGVKTFSVTVVVIGR 22243



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 42/153 (27%), Positives = 60/153 (39%), Gaps = 16/153 (10%)

Query: 276  LPAPDV--SWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEAT 333
            L  PDV   W L G+ + +    ++I   K  H LI    +    G  +  A N    A 
Sbjct: 5277 LSEPDVHGQWKLKGQPLTASPDCEIIEDGKK-HILILHNCQLGMTGEVSFQAANAKSAAN 5335

Query: 334  FTVQLDVLAKEHKRAPMFIYKPQSK-KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFN 392
              V         K  P+    P S  KV E D  K EC++S  P    + K   E+    
Sbjct: 5336 LKV---------KELPLIFITPLSDVKVFEKDEAKFECEVSREPKTFRWLKGTQEIT--G 5384

Query: 393  TDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSA 425
             DR  L +D T + +++IK    +D   Y   A
Sbjct: 5385 DDRFELIKDGT-KHSMVIKSAAFEDEAKYMFEA 5416



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 26/138 (18%), Positives = 62/138 (44%), Gaps = 9/138 (6%)

Query: 317   DAGAYACVAKNRAGEATFTVQLD--VLAKEHKRAPMFIYKPQ---SKKVLEGDSVKLECQ 371
             D   +  +A+N  G  +   Q    ++ ++    P+  + P+      +  G+S++++  
Sbjct: 21425 DRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKAL 21484

Query: 372   ISAIPPPKLFWKRNNEMVQFNTDRISL-YQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
             +   P P++ W ++   ++    R+++   D  G  +L ++D  +   G YTV A N +G
Sbjct: 21485 VQGRPVPRVTWFKDGVEIE---KRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASG 21541

Query: 431   VTTCNTRLDVTARPNQTL 448
                   ++ V   P + +
Sbjct: 21542 SAKAEIKVKVQDTPGKVV 21559



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 21/82 (25%), Positives = 41/82 (50%), Gaps = 2/82 (2%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G  + L+  +   P PK+ W + ++ +    +++SL Q    R T +IK  ++ D+G YT
Sbjct: 22565 GSDLVLDAAVGGKPEPKIIWTKGDKELDL-CEKVSL-QYTGKRATAVIKFCDRSDSGKYT 22622

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             ++  N +G    +  + V   P
Sbjct: 22623 LTVKNASGTKAVSVMVKVLDSP 22644



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 25/84 (29%), Positives = 42/84 (50%), Gaps = 3/84 (3%)

Query: 257   ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRAS 316
             + ++I  G   R+   VSG P P ++W   G  + S     +I + +    LI + V   
Sbjct: 22957 KTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLAS---RAIIDTTESYSLLIVDKVNRY 23013

Query: 317   DAGAYACVAKNRAGEATFTVQLDV 340
             DAG Y   A+N++G+ + TV + V
Sbjct: 23014 DAGKYTIEAENQSGKKSATVLVKV 23037



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 29/115 (25%), Positives = 42/115 (36%), Gaps = 12/115 (10%)

Query: 348   APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
             A   + KP+S  V EG+S +  C     P P + W R  +++  +T           + T
Sbjct: 26063 AARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVL--STSARHQVTTTKYKST 26120

Query: 408   LLIKDVNKKDAGWYTVSAVNEAGVTTCN----------TRLDVTARPNQTLPAPK 452
               I  V   D G Y+V   N  G               T   VT+ P    P P+
Sbjct: 26121 FEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPR 26175



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 24/69 (34%), Positives = 37/69 (53%), Gaps = 4/69 (5%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLL-IKDVNKKDAGWY 421
             G +++L   +   PPPK+ W + N  ++   DRI L   +T   T L  ++VNK DAG Y
Sbjct: 13211 GVTMRLYVPVKGRPPPKITWSKPNVNLR---DRIGLDIKSTDFDTFLRCENVNKYDAGKY 13267

Query: 422   TVSAVNEAG 430
              ++  N  G
Sbjct: 13268 ILTLENSCG 13276



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 27/92 (29%), Positives = 43/92 (46%), Gaps = 11/92 (11%)

Query: 341   LAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTD-RI 396
             +AKE +  P+F    + +K L    G S  +       P P + W + +      TD R 
Sbjct: 19679 IAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPD------TDLRT 19732

Query: 397   SLYQDNT-GRVTLLIKDVNKKDAGWYTVSAVN 427
               Y D T  R +L I++ N+ D+G YT++  N
Sbjct: 19733 RAYVDTTDSRTSLTIENANRNDSGKYTLTIQN 19764



 Score = 37.4 bits (85), Expect = 0.032
 Identities = 27/99 (27%), Positives = 41/99 (41%), Gaps = 3/99 (3%)

Query: 248   YPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQ-SDDLHKMIVSEKGLH 306
             + PR      +  +  G+  R    V   P  +V WY NG  +Q S  +H    +  G+ 
Sbjct: 25875 HAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIH--YTNTSGVL 25932

Query: 307   SLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEH 345
             +L        D+G Y  V  N  GEA+    LDV   ++
Sbjct: 25933 TLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDY 25971



 Score = 37.0 bits (84), Expect = 0.042
 Identities = 26/93 (27%), Positives = 45/93 (48%), Gaps = 4/93 (4%)

Query: 253   IQVPENM-SIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI-F 310
             +++P N  SI  G   +++  V G P P++SW  +G  ++     ++ V E    +++  
Sbjct: 17817 LKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTT--RVNVEETATSTVLHI 17874

Query: 311   EVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
             +     D G Y   A N AG AT  + + VL K
Sbjct: 17875 KEGNKDDFGKYTVTATNSAGTATENLSVIVLEK 17907



 Score = 37.0 bits (84), Expect = 0.042
 Identities = 28/120 (23%), Positives = 54/120 (45%), Gaps = 8/120 (6%)

Query: 227   VRSRSTSRGDVNDQDAIQEKFYPPRF---IQVPENMSIDEGRFCRMDFKVSGLPAPDVSW 283
             V   S S G +  +D ++    PPR    ++  + + +  G   +++  ++G P P +SW
Sbjct: 19271 VSEPSESTGPIIVKDDVE----PPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISW 19326

Query: 284   YLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
               +G  ++     ++I ++      + + +R  D G Y    KN AG  +  V   VL K
Sbjct: 19327 AKDGIEIEERARTEIISTDNHTLLTVKDCIR-RDTGQYVLTLKNVAGTRSVAVNCKVLDK 19385



 Score = 36.6 bits (83), Expect = 0.054
 Identities = 38/139 (27%), Positives = 63/139 (45%), Gaps = 15/139 (10%)

Query: 325   AKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVL---EGDSVKLECQISAIPPPKLF 381
             A N AG     V  DV   E + AP F    + ++ L    G S+++   I   P P++ 
Sbjct: 14253 AINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVT 14312

Query: 382   WKRNNEMVQFNTDRISLYQDNTGRVTLL-IKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
             W ++N  ++   +R ++  +NT   TLL I + N+ D G + ++  N AG  +    + V
Sbjct: 14313 WTKDNINLK---NRANI--ENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRV 14367

Query: 441   TARPNQTLPAPKQLRVRPT 459
                P         L +RPT
Sbjct: 14368 LDTPGPV------LNLRPT 14380



 Score = 36.6 bits (83), Expect = 0.054
 Identities = 30/132 (22%), Positives = 55/132 (41%), Gaps = 5/132 (3%)

Query: 347   RAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV 406
             +AP F  + ++  V    +  L C+++  P P + W R  + +  +  +  + +   G  
Sbjct: 24429 QAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYH 24488

Query: 407   TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLAL 466
              L+I  V   DA  Y V A N+ G  +    L+V       LP     +         AL
Sbjct: 24489 QLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLP-----KTLEGMGAVHAL 24543

Query: 467   NGKGLNVKQAFN 478
              G+ +++K  F+
Sbjct: 24544 RGEVVSIKIPFS 24555



 Score = 35.8 bits (81), Expect = 0.093
 Identities = 30/120 (25%), Positives = 56/120 (46%), Gaps = 12/120 (10%)

Query: 231  STSRGDVNDQDAIQEKFYPPRFIQV--PENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGR 288
            S + G++   D IQE+  P  FI +   + +    G   R+   + G P P  SW  +G+
Sbjct: 9296 SDTTGEIPATD-IQEE--PEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSWEFDGK 9352

Query: 289  TVQS--DDLHKM-----IVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
              ++  D +H +     + + +    +I    + S  G Y+  AKN+AG+ T   ++ V+
Sbjct: 9353 AKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVM 9412



 Score = 35.8 bits (81), Expect = 0.093
 Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 5/95 (5%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
             P   +   + ++I  G    +  + SG P P VSW+ +   V  DD   +  +     +L
Sbjct: 10321 PTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPA---TL 10377

Query: 309   IFEVVRA--SDAGAYACVAKNRAGEATFTVQLDVL 341
               E ++A  SD+G Y  V +N  G      Q++V+
Sbjct: 10378 ALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVV 10412



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 24/100 (24%), Positives = 44/100 (44%), Gaps = 10/100 (10%)

Query: 363  GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT------LLIKDVNKK 416
            G  +++   I   P PK  W+ + +  +   D +    ++    T      ++I +  + 
Sbjct: 9328 GSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRS 9387

Query: 417  DAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRV 456
              G Y+++A N+AG  T N R+ V   P      PK L+V
Sbjct: 9388 HTGKYSITAKNKAGQKTANCRVKVMDVPG----PPKDLKV 9423



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 42/166 (25%), Positives = 70/166 (42%), Gaps = 16/166 (9%)

Query: 298   MIVSEKGLHSLIFEVVRASDAGAY--ACVAKNRAGEATFT-VQLDVLAKEHKRAPMFIYK 354
             M     G++    EV +  +   Y     A N+AG      V   ++ +E   AP     
Sbjct: 16389 MCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLD 16448

Query: 355   PQSKKVLE---GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIK 411
              + +K++    G S++L   I   P P++ W + +  +     R +   D T   T L+ 
Sbjct: 16449 LELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEI-----RDAAIIDVTSSFTSLVL 16503

Query: 412   D-VNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRV 456
             D VN+ D+G YT++  N +G  +      VT R   T   P  L+V
Sbjct: 16504 DNVNRYDSGKYTLTLENSSGTKSA----FVTVRVLDTPSPPVNLKV 16545



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 25/110 (22%), Positives = 50/110 (45%), Gaps = 2/110 (1%)

Query: 340   VLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLY 399
             V+A++ +  P       +  V   + +K++      P   + W+++ + ++  T R+++ 
Sbjct: 18889 VIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLK-ETTRVNVS 18947

Query: 400   QDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLP 449
                T   +L IK+ +K+D G Y +   N AG  T    + V  RP    P
Sbjct: 18948 SSKTV-TSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGP 18996



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 25/94 (26%), Positives = 43/94 (45%), Gaps = 2/94 (2%)

Query: 348   APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
             AP    + +S +V  G + +    + + P  ++ W  N   +Q  + +I  Y + +G +T
Sbjct: 25876 APRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQ-ESSKIH-YTNTSGVLT 25933

Query: 408   LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVT 441
             L I D +  D+G Y     N  G  +    LDVT
Sbjct: 25934 LEILDCHTDDSGTYRAVCTNYKGEASDYATLDVT 25967



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 26/114 (22%), Positives = 50/114 (43%), Gaps = 8/114 (7%)

Query: 231   STSRGDVNDQDAIQEKFYPPRFIQVP---ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNG 287
             S S G +  +D ++     PR    P   + + ++ G   R++  V G P P + W    
Sbjct: 17111 SDSTGPITAKDEVEL----PRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGD 17166

Query: 288   RTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
             + ++     ++  ++     ++ + +R  D G Y   A N AG  +F V + VL
Sbjct: 17167 KEIEESARCEIKNTDFKALLIVKDAIRI-DGGQYILRASNVAGSKSFPVNVKVL 17219



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 22/104 (21%), Positives = 44/104 (42%), Gaps = 5/104 (4%)

Query: 240   QDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMI 299
             +D + E    P F     + S+  G+  +++  +SG P P ++W  +G  ++       +
Sbjct: 16727 KDLVIEPDVKPAF----SSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLK-QTTRINV 16781

Query: 300   VSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
                  L +L  +     D G Y     N  G+ T ++++  L K
Sbjct: 16782 TDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDK 16825



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 22/69 (31%), Positives = 34/69 (49%), Gaps = 3/69 (4%)

Query: 257  ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGL-HSLIFEVVRA 315
            +++++ EG    ++ KVS      V WYLN   ++ DD  + IV  KG    L+     A
Sbjct: 2406 KDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIV--KGTKQRLVINRTHA 2463

Query: 316  SDAGAYACV 324
            SD G Y  +
Sbjct: 2464 SDEGPYKLI 2472



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 27/126 (21%), Positives = 55/126 (43%), Gaps = 12/126 (9%)

Query: 253   IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEV 312
             ++  + + +  G   R++  VSG P P + W  +G+ ++     ++ +++    +L+ + 
Sbjct: 14968 VKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFST-NLVNKD 15026

Query: 313   VRASDAGAYACVAKNRAGEATFTVQLDVLAKE-HKRAPMFIYKPQSKKVLEGDSVKLECQ 371
                 D+GAY   A N  G A     + VL +      P+ + +  S+K          C 
Sbjct: 15027 STRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEK----------CV 15076

Query: 372   ISAIPP 377
             +S  PP
Sbjct: 15077 LSWFPP 15082



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 20/85 (23%), Positives = 37/85 (43%), Gaps = 2/85 (2%)

Query: 360   VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
             V  G+ +K+   I+  P P + W ++   ++       +  DN     L +KD  ++D G
Sbjct: 19304 VKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDN--HTLLTVKDCIRRDTG 19361

Query: 420   WYTVSAVNEAGVTTCNTRLDVTARP 444
              Y ++  N AG  +      V  +P
Sbjct: 19362 QYVLTLKNVAGTRSVAVNCKVLDKP 19386



 Score = 33.9 bits (76), Expect = 0.35
 Identities = 39/137 (28%), Positives = 60/137 (43%), Gaps = 11/137 (8%)

Query: 362  EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKD-AGW 420
            EGD V L   I+     ++ W   N++V  +     L   NT   TL+I  VN +D  G 
Sbjct: 4256 EGDIVHLTTSITNAK--EVNWYFENKLVPSDEKFKCLQDQNT--YTLVIDKVNTEDHQGE 4311

Query: 421  YTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNPE 480
            Y   A+N++G T  + +L V  R     P  K+ ++ P       L      ++ A  P 
Sbjct: 4312 YVCEALNDSGKTATSAKLTVVKR---AAPVIKR-KIEPLEVALGHLAKFTCEIQSA--PN 4365

Query: 481  GEFQRLAAQSGLYESEE 497
              FQ   A   +YES++
Sbjct: 4366 VRFQWFKAGREIYESDK 4382



 Score = 33.9 bits (76), Expect = 0.35
 Identities = 22/94 (23%), Positives = 37/94 (39%), Gaps = 4/94 (4%)

Query: 356   QSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNK 415
             Q+  V  G S++L       P P   W + +  +    D            TL +++ N+
Sbjct: 21868 QTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRAD----IHTTDSFSTLTVENCNR 21923

Query: 416   KDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLP 449
              DAG YT++  N +G  +    + V   P    P
Sbjct: 21924 NDAGKYTLTVENNSGSKSITFTVKVLDTPGPPGP 21957



 Score = 33.5 bits (75), Expect = 0.46
 Identities = 36/159 (22%), Positives = 62/159 (38%), Gaps = 16/159 (10%)

Query: 198   VFQAQDDSGAQDSQQHNSEHARLQVP------TSQVRSRSTSRGDVNDQDAIQEKFYPPR 251
             V +A  D+  + +   N +  R +V         Q R  + ++   +D   + +K YP  
Sbjct: 13130 VKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKD 13189

Query: 252   FIQVPEN---------MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSE 302
              +  PE          + +  G   R+   V G P P ++W      ++ D +   I S 
Sbjct: 13190 ILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLR-DRIGLDIKST 13248

Query: 303   KGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
                  L  E V   DAG Y    +N  G+  +T+ + VL
Sbjct: 13249 DFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVL 13287



 Score = 33.1 bits (74), Expect = 0.60
 Identities = 23/85 (27%), Positives = 38/85 (44%), Gaps = 2/85 (2%)

Query: 360   VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
             V  G +V+    I  +P P   W  +   ++ + +  ++  DN   V L IK+  ++D G
Sbjct: 11025 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTD-EHYTVETDNFSSV-LTIKNCLRRDTG 11082

Query: 420   WYTVSAVNEAGVTTCNTRLDVTARP 444
              Y ++  N AG  T    L V   P
Sbjct: 11083 EYQITVSNAAGSKTVAVHLTVLDVP 11107



 Score = 33.1 bits (74), Expect = 0.60
 Identities = 25/95 (26%), Positives = 39/95 (41%), Gaps = 1/95 (1%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
             PP F  +    ++  G   ++D    G P P V+W+ +   ++         +E      
Sbjct: 15650 PPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLT 15709

Query: 309   IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
             I +  R  D G Y     N AGEA  T+ + VL K
Sbjct: 15710 IKDACR-EDVGHYVVKLTNSAGEAIETLNVIVLDK 15743



 Score = 32.7 bits (73), Expect = 0.78
 Identities = 22/95 (23%), Positives = 38/95 (40%), Gaps = 7/95 (7%)

Query: 249   PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
             P + I VP       GR   +   ++G P P  SW+  G  ++  +    + +   +  L
Sbjct: 23247 PQKTIHVPA------GRPVELVIPIAGRPPPAASWFFAGSKLRESE-RVTVETHTKVAKL 23299

Query: 309   IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
                     D G Y    KN  G  + T+++ +L K
Sbjct: 23300 TIRETTIRDTGEYTLELKNVTGTTSETIKVIILDK 23334



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 30/134 (22%), Positives = 44/134 (32%), Gaps = 9/134 (6%)

Query: 216  EHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPP----RFIQVPENMSIDEGRFCRMDF 271
            EH   +     V     S   +     IQ+   PP    R     + + +  G    +  
Sbjct: 8864 EHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPA 8923

Query: 272  KVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHS-----LIFEVVRASDAGAYACVAK 326
             V+GLP P + W  N   ++       I  E+   S     L        D G Y   A 
Sbjct: 8924 DVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTAS 8983

Query: 327  NRAGEATFTVQLDV 340
            NR G     V ++V
Sbjct: 8984 NRLGSVFRNVHVEV 8997



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 33/126 (26%), Positives = 58/126 (46%), Gaps = 8/126 (6%)

Query: 365   SVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIK-DVNKKDAGWYTV 423
             +++L   I   P P++ W R++     + D+ S+  ++T   TLLI  +VN+ D+G Y +
Sbjct: 15380 TLRLFVPIKGRPAPEVKWARDHGE---SLDKASI--ESTSSYTLLIVGNVNRFDSGKYIL 15434

Query: 424   SAVNEAGVTTC--NTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNPEG 481
             +  N +G  +   N R+  T  P Q L   +  +   T +    L   G  +K     + 
Sbjct: 15435 TVENSSGSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVEKR 15494

Query: 482   EFQRLA 487
             E  R A
Sbjct: 15495 ESTRKA 15500



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 23/87 (26%), Positives = 34/87 (39%), Gaps = 1/87 (1%)

Query: 273   VSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEA 332
             + G P P  SW   G+ ++  D+   I S      L  +     DAG Y   A N  G  
Sbjct: 13906 ILGKPLPKSSWSKAGKDIRPSDI-TQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTK 13964

Query: 333   TFTVQLDVLAKEHKRAPMFIYKPQSKK 359
                V++ VL       P+ I    ++K
Sbjct: 13965 VEHVKVTVLDVPGPPGPVEISNVSAEK 13991



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 26/109 (23%), Positives = 46/109 (42%), Gaps = 6/109 (5%)

Query: 236   DVNDQDAIQEKFYPPRF---IQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQS 292
             DV     ++EK   P     +++ + ++I  G   R+   + G P P+V W   G+    
Sbjct: 16429 DVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKW---GKVDGE 16485

Query: 293   DDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
                  +I       SL+ + V   D+G Y    +N +G  +  V + VL
Sbjct: 16486 IRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVL 16534



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 20/82 (24%), Positives = 40/82 (48%), Gaps = 2/82 (2%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G  V+L   I+  PPP   W      ++  ++R+++ + +T    L I++   +D G YT
Sbjct: 23256 GRPVELVIPIAGRPPPAASWFFAGSKLR-ESERVTV-ETHTKVAKLTIRETTIRDTGEYT 23313

Query: 423   VSAVNEAGVTTCNTRLDVTARP 444
             +   N  G T+   ++ +  +P
Sbjct: 23314 LELKNVTGTTSETIKVIILDKP 23335



 Score = 30.8 bits (68), Expect = 3.0
 Identities = 23/87 (26%), Positives = 37/87 (42%), Gaps = 14/87 (16%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT-----LLIKDVNKKD 417
             G  +++   +S  PPP + W  N           +L Q+ T   T     ++IK+  +  
Sbjct: 10042 GGVIRIIAYVSGKPPPTVTWNMNER---------TLPQEATIETTAISSSMVIKNCQRSH 10092

Query: 418   AGWYTVSAVNEAGVTTCNTRLDVTARP 444
              G Y++ A NEAG       +DV   P
Sbjct: 10093 QGVYSLLAKNEAGERKKTIIVDVLDVP 10119



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 24/105 (22%), Positives = 43/105 (40%), Gaps = 13/105 (12%)

Query: 274  SGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEAT 333
            +G P P  +W    + +++ D  KM  +      L+      SD G Y    +NR    +
Sbjct: 6922 TGYPRPTATWCFGDKVLETGDRVKM-KTLSAYAELVISPSERSDKGIYTLKLENRVKTIS 6980

Query: 334  FTVQLDVLAKEHKRAPMFIYKPQSKKVLE-GDSVKLECQISAIPP 377
              + ++V+A           +P + K L+ GD  K    ++  PP
Sbjct: 6981 GEIDVNVIA-----------RPSAPKELKFGDITKDSVHLTWEPP 7014



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 25/113 (22%), Positives = 45/113 (39%), Gaps = 5/113 (4%)

Query: 231   STSRGDVNDQDAIQ--EKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGR 288
             S S G +  +D I        P++  V   + +  G    ++  + G P PDV W  +G+
Sbjct: 18193 SDSSGAITARDEIDAPNASLDPKYKDV---IVVHAGETFVLEADIRGKPIPDVVWSKDGK 18249

Query: 289   TVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
              ++       I S     +L+ +    +D G Y     N  G  +  + + VL
Sbjct: 18250 ELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVL 18302



 Score = 30.0 bits (66), Expect = 5.1
 Identities = 25/96 (26%), Positives = 48/96 (50%), Gaps = 7/96 (7%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLL-IKDVNKKDAGWY 421
             G+ V++       PPP + W+++ + +  +  R S+  +NT   +LL I  V + D G Y
Sbjct: 20789 GEDVQVLIPFKGRPPPTVTWRKDEKNLGSDA-RYSI--ENTDSSSLLTIPQVTRNDTGKY 20845

Query: 422   TVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVR 457
              ++  N  G    +T   V+ +   T  A ++L+V+
Sbjct: 20846 ILTIENGVGEPKSST---VSVKVLDTPAACQKLQVK 20878



 Score = 30.0 bits (66), Expect = 5.1
 Identities = 16/61 (26%), Positives = 26/61 (42%), Gaps = 2/61 (3%)

Query: 363   GDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             G +V LE      P P + W ++   +         +     ++TL IK+  K+  G YT
Sbjct: 21081 GHNVHLELPYKGKPKPSISWLKDG--LPLKESEFVRFSKTENKITLSIKNAKKEHGGKYT 21138

Query: 423   V 423
             V
Sbjct: 21139 V 21139



 Score = 29.6 bits (65), Expect = 6.6
 Identities = 24/102 (23%), Positives = 42/102 (41%), Gaps = 8/102 (7%)

Query: 244   QEKFYPPRFIQVPENMSIDEGRFC---RMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIV 300
             +++  PP      +   +   R C   R+   + G PAP+V W  +      + L K  +
Sbjct: 15355 EDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARD----HGESLDKASI 15410

Query: 301   SEKGLHS-LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVL 341
                  ++ LI   V   D+G Y    +N +G  +  V + VL
Sbjct: 15411 ESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVL 15452



 Score = 29.6 bits (65), Expect = 6.6
 Identities = 21/84 (25%), Positives = 36/84 (42%), Gaps = 3/84 (3%)

Query: 259   MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL-IFEVVRASD 317
             ++I  G    +D  V G P P + W    + +  D   K+ +   G  +  + +    SD
Sbjct: 22560 VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKEL--DLCEKVSLQYTGKRATAVIKFCDRSD 22617

Query: 318   AGAYACVAKNRAGEATFTVQLDVL 341
             +G Y    KN +G    +V + VL
Sbjct: 22618 SGKYTLTVKNASGTKAVSVMVKVL 22641



 Score = 29.3 bits (64), Expect = 8.7
 Identities = 18/86 (20%), Positives = 37/86 (43%), Gaps = 4/86 (4%)

Query: 360   VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
             V +G  ++L   I   P P   W +  + +     + ++   +     L+IK+ ++ D+G
Sbjct: 23651 VRQGGVIRLTIPIKGKPFPICKWTKEGQDIS----KRAMIATSETHTELVIKEADRGDSG 23706

Query: 420   WYTVSAVNEAGVTTCNTRLDVTARPN 445
              Y +   N+ G      ++ V   PN
Sbjct: 23707 TYDLVLENKCGKKAVYIKVRVIGSPN 23732


>gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]
          Length = 1863

 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 65/206 (31%), Positives = 94/206 (45%), Gaps = 6/206 (2%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQ-SDDLHKMIVSEKGL-HS 307
           P F+Q   ++ + +G    M  +VSG P P+V W  NG  +Q S+D H     ++G  HS
Sbjct: 623 PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFH---FEQRGTQHS 679

Query: 308 LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
           L  + V   D G Y C A N AGE      L V        P FI KP+S     G SV 
Sbjct: 680 LCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVL 739

Query: 368 LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
           + C I+  P P + W R+ + +  +T    + Q N    TL++K V    AG Y +   N
Sbjct: 740 ISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQ-NEDVFTLVLKKVQPWHAGQYEILLKN 798

Query: 428 EAGVTTCNTRLDVTARPNQTLPAPKQ 453
             G  +C   L +     + LP  ++
Sbjct: 799 RVGECSCQVSLMLQNSSARALPRGRE 824



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 69/261 (26%), Positives = 119/261 (45%), Gaps = 19/261 (7%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P+F   P++  + E +  +   +VSG+P P+V+W+L G  V+  +    +  + G H L 
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLC 473

Query: 310 FEVVRASDAGAYACVAKNRAGE--ATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
               R  D+G Y+C A N  G+   ++T+Q++ LA   + AP F    +   V+EG    
Sbjct: 474 LLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLA-VMEVAPSFSSVLKDCAVIEGQDFV 532

Query: 368 LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
           L+C +   P P++ W  N + +Q+            G   L I+D   +D G YT  A N
Sbjct: 533 LQCSVRGTPVPRITWLLNGQPIQYARSTC-----EAGVAELHIQDALPEDHGTYTCLAEN 587

Query: 428 EAGVTTCNTRLDV-----TARPNQTLPAPKQLRVRPTFSKYLA----LNGK--GLNVKQA 476
             G  +C+  + V     + +    LP        P F + L+    ++G    + V+ +
Sbjct: 588 ALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVS 647

Query: 477 FNPEGEFQRLAAQSGLYESEE 497
            NP  E   L   + + ESE+
Sbjct: 648 GNPPPEVIWLHNGNEIQESED 668



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 62/220 (28%), Positives = 92/220 (41%), Gaps = 31/220 (14%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P FI  P N+ I EG   + + +V G P P V+W+ NG+ + S     +    +G  SL+
Sbjct: 33  PAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLV 92

Query: 310 FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKR---------------------- 347
              V   D G Y C A N +G    TV+L V     K+                      
Sbjct: 93  IHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETR 152

Query: 348 -------APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQ 400
                   P F  K     V EG   +  C+I+  P P++ W + N  +Q  + R+S+ +
Sbjct: 153 PSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQ-PSARVSVSE 211

Query: 401 DNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
            N G   L I  VN+ D G YT   VN +G  + +  L +
Sbjct: 212 KN-GMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 86/416 (20%), Positives = 157/416 (37%), Gaps = 62/416 (14%)

Query: 94   ASFLSSILPSQPDYNSSKIPSAMDSNYQQSSAGQPINAKPSQTANAKPIPRTPD-HEIQG 152
            A+    + P        K+ S    +++   A +  +  P       P P TPD   + G
Sbjct: 927  ANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLG 986

Query: 153  SKEAL--------IQDLERKLKCKDTLLHN----GNQRLTYEEKMARRL--LGPQNAAAV 198
             K+ L         + L  K       L N    G  +     K A  L  +G    A  
Sbjct: 987  GKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAET 1046

Query: 199  FQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPEN 258
             +   ++   ++ +  S+    +   + V  +    G  +++   + +   P F Q  ++
Sbjct: 1047 LKPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQD 1106

Query: 259  MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG-LHSLIFEVVRASD 317
            + + EG+   +  +VS  P   + W LNG+T+++     +I+S++G L S+  E     D
Sbjct: 1107 VHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKF--IILSQEGSLCSVSIEKALPED 1164

Query: 318  AGAYACVAKNRAGEATFTVQL---DVLAKEHKRA-------------------------- 348
             G Y CVAKN AG+A  + Q+   D  A E+ +A                          
Sbjct: 1165 RGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKK 1224

Query: 349  -------------PMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDR 395
                         P  I  P+ +KV  G+SV+L  +++   P    W +  + +Q +   
Sbjct: 1225 KPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHM 1284

Query: 396  ISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAP 451
                 +N  ++T+L     ++  G YT+   N+ G       L V  +P+     P
Sbjct: 1285 KVENSENGSKLTILA--ARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTP 1338



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 39/127 (30%), Positives = 60/127 (47%), Gaps = 5/127 (3%)

Query: 223  PTSQVRSRST-SRGDVNDQ--DAIQEK--FYPPRFIQVPENMSIDEGRFCRMDFKVSGLP 277
            PTS + +    S  DV+    +A+ E+     P F +   ++ + EG   R D K+ G P
Sbjct: 1726 PTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYP 1785

Query: 278  APDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQ 337
             P+V W+ + ++++     ++   E G  SLI   V   D   Y C A N  GEAT T +
Sbjct: 1786 DPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAE 1845

Query: 338  LDVLAKE 344
            L V   E
Sbjct: 1846 LIVETME 1852



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 30/104 (28%), Positives = 52/104 (50%), Gaps = 2/104 (1%)

Query: 338  LDVLAKEHKRA-PMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRI 396
            L+ +A+E     P F    +  +V+EG + + +C+I   P P++ W ++++ ++  +   
Sbjct: 1746 LEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIR-ESRHF 1804

Query: 397  SLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
             +  D  G  +L+I DV   D   YT  AVN  G  TC   L V
Sbjct: 1805 QIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIV 1848



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 33/115 (28%), Positives = 54/115 (46%), Gaps = 3/115 (2%)

Query: 348  APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
            AP F  K Q   V EG  + L+CQ+S+ PP  + W  N + ++  T +  +        +
Sbjct: 1097 APAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLK--TTKFIILSQEGSLCS 1154

Query: 408  LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARP-NQTLPAPKQLRVRPTFS 461
            + I+    +D G Y   A N+AG   C+ ++ V   P ++   AP+    RP  S
Sbjct: 1155 VSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSS 1209



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 25/92 (27%), Positives = 42/92 (45%), Gaps = 1/92 (1%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
           PP+F      + + EG+  R   K++G P P V+W L G           +  + G+  L
Sbjct: 160 PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTW-LKGNVPLQPSARVSVSEKNGMQVL 218

Query: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
               V   D G Y C+  N +G+A+ + +L +
Sbjct: 219 EIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 83/375 (22%), Positives = 140/375 (37%), Gaps = 51/375 (13%)

Query: 13   SQNPCGSRLQPPGPETSSFSSQTKQSSIIIQPRQCTEQRFSASSTLSSHITMS----SSA 68
            S+ P   ++ PP P T  F     +S +  + +   E   S++ TL++    S    S+A
Sbjct: 963  SKTPVPEKVPPPKPATPDF-----RSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNA 1017

Query: 69   FPASPQQHAG-SNPGQRVTTTYNQSPASFLSSILPSQPDYN-------SSKIPSAMDSNY 120
             P+ P +  G + P + +    N  PA  L  +  ++PD N         K     D N 
Sbjct: 1018 QPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNC 1077

Query: 121  QQSSAGQPINAKPSQTANAKPI--PRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQR 178
            ++  AG   N K S++    P    +  D  +   K+ L+Q  +       T++   N +
Sbjct: 1078 KRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQ-CQVSSDPPATIIWTLNGK 1136

Query: 179  LTYEEKM-------------ARRLLGPQNAAAVFQAQDDSG-AQDSQQHNSEHA----RL 220
                 K                + L          A++D+G A+ S Q   + A      
Sbjct: 1137 TLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENT 1196

Query: 221  QVPTSQVRSRSTSRGDV--NDQDAIQEK----------FYPPRFIQVPENMSIDEGRFCR 268
            + P  + R   +S   V   + DA  +K            PP+ IQ PE+  +  G    
Sbjct: 1197 KAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVE 1256

Query: 269  MDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNR 328
            +  KV+G      +W    + +Q  +  K+  SE G   L     R    G Y  + +N+
Sbjct: 1257 LFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENG-SKLTILAARQEHCGCYTLLVENK 1315

Query: 329  AGEATFTVQLDVLAK 343
             G     V L V+ K
Sbjct: 1316 LGSRQAQVNLTVVDK 1330



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 1/93 (1%)

Query: 348 APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
           AP FI  P++  + EG + K E ++   P P++ W RN + +  +  R  L     G  +
Sbjct: 32  APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPIT-SGGRFLLDCGIRGTFS 90

Query: 408 LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
           L+I  V+++D G YT  A N +G       L V
Sbjct: 91  LVIHAVHEEDRGKYTCEATNGSGARQVTVELTV 123


>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
          Length = 1914

 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 65/206 (31%), Positives = 94/206 (45%), Gaps = 6/206 (2%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQ-SDDLHKMIVSEKGL-HS 307
           P F+Q   ++ + +G    M  +VSG P P+V W  NG  +Q S+D H     ++G  HS
Sbjct: 623 PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFH---FEQRGTQHS 679

Query: 308 LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
           L  + V   D G Y C A N AGE      L V        P FI KP+S     G SV 
Sbjct: 680 LCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVL 739

Query: 368 LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
           + C I+  P P + W R+ + +  +T    + Q N    TL++K V    AG Y +   N
Sbjct: 740 ISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQ-NEDVFTLVLKKVQPWHAGQYEILLKN 798

Query: 428 EAGVTTCNTRLDVTARPNQTLPAPKQ 453
             G  +C   L +     + LP  ++
Sbjct: 799 RVGECSCQVSLMLQNSSARALPRGRE 824



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 69/261 (26%), Positives = 119/261 (45%), Gaps = 19/261 (7%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P+F   P++  + E +  +   +VSG+P P+V+W+L G  V+  +    +  + G H L 
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLC 473

Query: 310 FEVVRASDAGAYACVAKNRAGE--ATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
               R  D+G Y+C A N  G+   ++T+Q++ LA   + AP F    +   V+EG    
Sbjct: 474 LLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLA-VMEVAPSFSSVLKDCAVIEGQDFV 532

Query: 368 LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
           L+C +   P P++ W  N + +Q+            G   L I+D   +D G YT  A N
Sbjct: 533 LQCSVRGTPVPRITWLLNGQPIQYARSTC-----EAGVAELHIQDALPEDHGTYTCLAEN 587

Query: 428 EAGVTTCNTRLDV-----TARPNQTLPAPKQLRVRPTFSKYLA----LNGK--GLNVKQA 476
             G  +C+  + V     + +    LP        P F + L+    ++G    + V+ +
Sbjct: 588 ALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVS 647

Query: 477 FNPEGEFQRLAAQSGLYESEE 497
            NP  E   L   + + ESE+
Sbjct: 648 GNPPPEVIWLHNGNEIQESED 668



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 62/220 (28%), Positives = 92/220 (41%), Gaps = 31/220 (14%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P FI  P N+ I EG   + + +V G P P V+W+ NG+ + S     +    +G  SL+
Sbjct: 33  PAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLV 92

Query: 310 FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKR---------------------- 347
              V   D G Y C A N +G    TV+L V     K+                      
Sbjct: 93  IHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETR 152

Query: 348 -------APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQ 400
                   P F  K     V EG   +  C+I+  P P++ W + N  +Q  + R+S+ +
Sbjct: 153 PSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQ-PSARVSVSE 211

Query: 401 DNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
            N G   L I  VN+ D G YT   VN +G  + +  L +
Sbjct: 212 KN-GMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 86/416 (20%), Positives = 157/416 (37%), Gaps = 62/416 (14%)

Query: 94   ASFLSSILPSQPDYNSSKIPSAMDSNYQQSSAGQPINAKPSQTANAKPIPRTPD-HEIQG 152
            A+    + P        K+ S    +++   A +  +  P       P P TPD   + G
Sbjct: 927  ANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLG 986

Query: 153  SKEAL--------IQDLERKLKCKDTLLHN----GNQRLTYEEKMARRL--LGPQNAAAV 198
             K+ L         + L  K       L N    G  +     K A  L  +G    A  
Sbjct: 987  GKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAET 1046

Query: 199  FQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPEN 258
             +   ++   ++ +  S+    +   + V  +    G  +++   + +   P F Q  ++
Sbjct: 1047 LKPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQD 1106

Query: 259  MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG-LHSLIFEVVRASD 317
            + + EG+   +  +VS  P   + W LNG+T+++     +I+S++G L S+  E     D
Sbjct: 1107 VHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKF--IILSQEGSLCSVSIEKALPED 1164

Query: 318  AGAYACVAKNRAGEATFTVQL---DVLAKEHKRA-------------------------- 348
             G Y CVAKN AG+A  + Q+   D  A E+ +A                          
Sbjct: 1165 RGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKK 1224

Query: 349  -------------PMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDR 395
                         P  I  P+ +KV  G+SV+L  +++   P    W +  + +Q +   
Sbjct: 1225 KPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHM 1284

Query: 396  ISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAP 451
                 +N  ++T+L     ++  G YT+   N+ G       L V  +P+     P
Sbjct: 1285 KVENSENGSKLTILA--ARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTP 1338



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 39/127 (30%), Positives = 60/127 (47%), Gaps = 5/127 (3%)

Query: 223  PTSQVRSRST-SRGDVNDQ--DAIQEK--FYPPRFIQVPENMSIDEGRFCRMDFKVSGLP 277
            PTS + +    S  DV+    +A+ E+     P F +   ++ + EG   R D K+ G P
Sbjct: 1777 PTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYP 1836

Query: 278  APDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQ 337
             P+V W+ + ++++     ++   E G  SLI   V   D   Y C A N  GEAT T +
Sbjct: 1837 DPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAE 1896

Query: 338  LDVLAKE 344
            L V   E
Sbjct: 1897 LIVETME 1903



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 30/104 (28%), Positives = 52/104 (50%), Gaps = 2/104 (1%)

Query: 338  LDVLAKEHKRA-PMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRI 396
            L+ +A+E     P F    +  +V+EG + + +C+I   P P++ W ++++ ++  +   
Sbjct: 1797 LEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIR-ESRHF 1855

Query: 397  SLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
             +  D  G  +L+I DV   D   YT  AVN  G  TC   L V
Sbjct: 1856 QIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIV 1899



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 33/115 (28%), Positives = 54/115 (46%), Gaps = 3/115 (2%)

Query: 348  APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
            AP F  K Q   V EG  + L+CQ+S+ PP  + W  N + ++  T +  +        +
Sbjct: 1097 APAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLK--TTKFIILSQEGSLCS 1154

Query: 408  LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARP-NQTLPAPKQLRVRPTFS 461
            + I+    +D G Y   A N+AG   C+ ++ V   P ++   AP+    RP  S
Sbjct: 1155 VSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSS 1209



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 25/92 (27%), Positives = 42/92 (45%), Gaps = 1/92 (1%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
           PP+F      + + EG+  R   K++G P P V+W L G           +  + G+  L
Sbjct: 160 PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTW-LKGNVPLQPSARVSVSEKNGMQVL 218

Query: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
               V   D G Y C+  N +G+A+ + +L +
Sbjct: 219 EIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 83/375 (22%), Positives = 140/375 (37%), Gaps = 51/375 (13%)

Query: 13   SQNPCGSRLQPPGPETSSFSSQTKQSSIIIQPRQCTEQRFSASSTLSSHITMS----SSA 68
            S+ P   ++ PP P T  F     +S +  + +   E   S++ TL++    S    S+A
Sbjct: 963  SKTPVPEKVPPPKPATPDF-----RSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNA 1017

Query: 69   FPASPQQHAG-SNPGQRVTTTYNQSPASFLSSILPSQPDYN-------SSKIPSAMDSNY 120
             P+ P +  G + P + +    N  PA  L  +  ++PD N         K     D N 
Sbjct: 1018 QPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNC 1077

Query: 121  QQSSAGQPINAKPSQTANAKPI--PRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQR 178
            ++  AG   N K S++    P    +  D  +   K+ L+Q  +       T++   N +
Sbjct: 1078 KRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQ-CQVSSDPPATIIWTLNGK 1136

Query: 179  LTYEEKM-------------ARRLLGPQNAAAVFQAQDDSG-AQDSQQHNSEHA----RL 220
                 K                + L          A++D+G A+ S Q   + A      
Sbjct: 1137 TLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENT 1196

Query: 221  QVPTSQVRSRSTSRGDV--NDQDAIQEK----------FYPPRFIQVPENMSIDEGRFCR 268
            + P  + R   +S   V   + DA  +K            PP+ IQ PE+  +  G    
Sbjct: 1197 KAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVE 1256

Query: 269  MDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNR 328
            +  KV+G      +W    + +Q  +  K+  SE G   L     R    G Y  + +N+
Sbjct: 1257 LFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENG-SKLTILAARQEHCGCYTLLVENK 1315

Query: 329  AGEATFTVQLDVLAK 343
             G     V L V+ K
Sbjct: 1316 LGSRQAQVNLTVVDK 1330



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 1/93 (1%)

Query: 348 APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
           AP FI  P++  + EG + K E ++   P P++ W RN + +  +  R  L     G  +
Sbjct: 32  APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPIT-SGGRFLLDCGIRGTFS 90

Query: 408 LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
           L+I  V+++D G YT  A N +G       L V
Sbjct: 91  LVIHAVHEEDRGKYTCEATNGSGARQVTVELTV 123


>gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens]
          Length = 1794

 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 65/206 (31%), Positives = 94/206 (45%), Gaps = 6/206 (2%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQ-SDDLHKMIVSEKGL-HS 307
           P F+Q   ++ + +G    M  +VSG P P+V W  NG  +Q S+D H     ++G  HS
Sbjct: 554 PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFH---FEQRGTQHS 610

Query: 308 LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
           L  + V   D G Y C A N AGE      L V        P FI KP+S     G SV 
Sbjct: 611 LCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVL 670

Query: 368 LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
           + C I+  P P + W R+ + +  +T    + Q N    TL++K V    AG Y +   N
Sbjct: 671 ISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQ-NEDVFTLVLKKVQPWHAGQYEILLKN 729

Query: 428 EAGVTTCNTRLDVTARPNQTLPAPKQ 453
             G  +C   L +     + LP  ++
Sbjct: 730 RVGECSCQVSLMLQNSSARALPRGRE 755



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 62/220 (28%), Positives = 92/220 (41%), Gaps = 31/220 (14%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P FI  P N+ I EG   + + +V G P P V+W+ NG+ + S     +    +G  SL+
Sbjct: 33  PAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLV 92

Query: 310 FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKR---------------------- 347
              V   D G Y C A N +G    TV+L V     K+                      
Sbjct: 93  IHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETR 152

Query: 348 -------APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQ 400
                   P F  K     V EG   +  C+I+  P P++ W + N  +Q  + R+S+ +
Sbjct: 153 PSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQ-PSARVSVSE 211

Query: 401 DNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
            N G   L I  VN+ D G YT   VN +G  + +  L +
Sbjct: 212 KN-GMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 58/214 (27%), Positives = 96/214 (44%), Gaps = 20/214 (9%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P F  V ++ ++ EG+   +   V G P P ++W LNG+ +Q    +     E G+  L 
Sbjct: 445 PSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQ----YARSTCEAGVAELH 500

Query: 310 FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKR--------------APMFIYKP 355
            +     D G Y C+A+N  G+ + +  + V  K+  R              AP+F+   
Sbjct: 501 IQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGL 560

Query: 356 QSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNK 415
              KV++G  V +  Q+S  PPP++ W  N   +Q + D    ++    + +L I++V  
Sbjct: 561 SDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESED--FHFEQRGTQHSLCIQEVFP 618

Query: 416 KDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLP 449
           +D G YT  A N AG       L V    + T P
Sbjct: 619 EDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQP 652



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 86/416 (20%), Positives = 157/416 (37%), Gaps = 62/416 (14%)

Query: 94   ASFLSSILPSQPDYNSSKIPSAMDSNYQQSSAGQPINAKPSQTANAKPIPRTPD-HEIQG 152
            A+    + P        K+ S    +++   A +  +  P       P P TPD   + G
Sbjct: 858  ANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLG 917

Query: 153  SKEAL--------IQDLERKLKCKDTLLHN----GNQRLTYEEKMARRL--LGPQNAAAV 198
             K+ L         + L  K       L N    G  +     K A  L  +G    A  
Sbjct: 918  GKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAET 977

Query: 199  FQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPEN 258
             +   ++   ++ +  S+    +   + V  +    G  +++   + +   P F Q  ++
Sbjct: 978  LKPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQD 1037

Query: 259  MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG-LHSLIFEVVRASD 317
            + + EG+   +  +VS  P   + W LNG+T+++     +I+S++G L S+  E     D
Sbjct: 1038 VHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKF--IILSQEGSLCSVSIEKALPED 1095

Query: 318  AGAYACVAKNRAGEATFTVQL---DVLAKEHKRA-------------------------- 348
             G Y CVAKN AG+A  + Q+   D  A E+ +A                          
Sbjct: 1096 RGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKK 1155

Query: 349  -------------PMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDR 395
                         P  I  P+ +KV  G+SV+L  +++   P    W +  + +Q +   
Sbjct: 1156 KPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHM 1215

Query: 396  ISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAP 451
                 +N  ++T+L     ++  G YT+   N+ G       L V  +P+     P
Sbjct: 1216 KVENSENGSKLTILA--ARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTP 1269



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 39/127 (30%), Positives = 60/127 (47%), Gaps = 5/127 (3%)

Query: 223  PTSQVRSRST-SRGDVNDQ--DAIQEK--FYPPRFIQVPENMSIDEGRFCRMDFKVSGLP 277
            PTS + +    S  DV+    +A+ E+     P F +   ++ + EG   R D K+ G P
Sbjct: 1657 PTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYP 1716

Query: 278  APDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQ 337
             P+V W+ + ++++     ++   E G  SLI   V   D   Y C A N  GEAT T +
Sbjct: 1717 DPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAE 1776

Query: 338  LDVLAKE 344
            L V   E
Sbjct: 1777 LIVETME 1783



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 30/104 (28%), Positives = 52/104 (50%), Gaps = 2/104 (1%)

Query: 338  LDVLAKEHKRA-PMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRI 396
            L+ +A+E     P F    +  +V+EG + + +C+I   P P++ W ++++ ++  +   
Sbjct: 1677 LEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIR-ESRHF 1735

Query: 397  SLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
             +  D  G  +L+I DV   D   YT  AVN  G  TC   L V
Sbjct: 1736 QIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIV 1779



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 33/115 (28%), Positives = 54/115 (46%), Gaps = 3/115 (2%)

Query: 348  APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
            AP F  K Q   V EG  + L+CQ+S+ PP  + W  N + ++  T +  +        +
Sbjct: 1028 APAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLK--TTKFIILSQEGSLCS 1085

Query: 408  LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARP-NQTLPAPKQLRVRPTFS 461
            + I+    +D G Y   A N+AG   C+ ++ V   P ++   AP+    RP  S
Sbjct: 1086 VSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSS 1140



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 25/92 (27%), Positives = 42/92 (45%), Gaps = 1/92 (1%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
           PP+F      + + EG+  R   K++G P P V+W L G           +  + G+  L
Sbjct: 160 PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTW-LKGNVPLQPSARVSVSEKNGMQVL 218

Query: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
               V   D G Y C+  N +G+A+ + +L +
Sbjct: 219 EIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 83/375 (22%), Positives = 140/375 (37%), Gaps = 51/375 (13%)

Query: 13   SQNPCGSRLQPPGPETSSFSSQTKQSSIIIQPRQCTEQRFSASSTLSSHITMS----SSA 68
            S+ P   ++ PP P T  F     +S +  + +   E   S++ TL++    S    S+A
Sbjct: 894  SKTPVPEKVPPPKPATPDF-----RSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNA 948

Query: 69   FPASPQQHAG-SNPGQRVTTTYNQSPASFLSSILPSQPDYN-------SSKIPSAMDSNY 120
             P+ P +  G + P + +    N  PA  L  +  ++PD N         K     D N 
Sbjct: 949  QPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNC 1008

Query: 121  QQSSAGQPINAKPSQTANAKPI--PRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQR 178
            ++  AG   N K S++    P    +  D  +   K+ L+Q  +       T++   N +
Sbjct: 1009 KRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQ-CQVSSDPPATIIWTLNGK 1067

Query: 179  LTYEEKM-------------ARRLLGPQNAAAVFQAQDDSG-AQDSQQHNSEHA----RL 220
                 K                + L          A++D+G A+ S Q   + A      
Sbjct: 1068 TLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENT 1127

Query: 221  QVPTSQVRSRSTSRGDV--NDQDAIQEK----------FYPPRFIQVPENMSIDEGRFCR 268
            + P  + R   +S   V   + DA  +K            PP+ IQ PE+  +  G    
Sbjct: 1128 KAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVE 1187

Query: 269  MDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNR 328
            +  KV+G      +W    + +Q  +  K+  SE G   L     R    G Y  + +N+
Sbjct: 1188 LFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENG-SKLTILAARQEHCGCYTLLVENK 1246

Query: 329  AGEATFTVQLDVLAK 343
             G     V L V+ K
Sbjct: 1247 LGSRQAQVNLTVVDK 1261



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 1/93 (1%)

Query: 348 APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
           AP FI  P++  + EG + K E ++   P P++ W RN + +  +  R  L     G  +
Sbjct: 32  APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPIT-SGGRFLLDCGIRGTFS 90

Query: 408 LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
           L+I  V+++D G YT  A N +G       L V
Sbjct: 91  LVIHAVHEEDRGKYTCEATNGSGARQVTVELTV 123



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 40/161 (24%), Positives = 66/161 (40%), Gaps = 16/161 (9%)

Query: 348 APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
           AP F    +   V+EG    L+C +   P P++ W  N + +Q+            G   
Sbjct: 444 APSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTC-----EAGVAE 498

Query: 408 LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV-----TARPNQTLPAPKQLRVRPTFSK 462
           L I+D   +D G YT  A N  G  +C+  + V     + +    LP        P F +
Sbjct: 499 LHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQ 558

Query: 463 YLA----LNGK--GLNVKQAFNPEGEFQRLAAQSGLYESEE 497
            L+    ++G    + V+ + NP  E   L   + + ESE+
Sbjct: 559 GLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESED 599


>gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]
          Length = 1845

 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 65/206 (31%), Positives = 94/206 (45%), Gaps = 6/206 (2%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQ-SDDLHKMIVSEKGL-HS 307
           P F+Q   ++ + +G    M  +VSG P P+V W  NG  +Q S+D H     ++G  HS
Sbjct: 554 PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFH---FEQRGTQHS 610

Query: 308 LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
           L  + V   D G Y C A N AGE      L V        P FI KP+S     G SV 
Sbjct: 611 LCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVL 670

Query: 368 LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
           + C I+  P P + W R+ + +  +T    + Q N    TL++K V    AG Y +   N
Sbjct: 671 ISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQ-NEDVFTLVLKKVQPWHAGQYEILLKN 729

Query: 428 EAGVTTCNTRLDVTARPNQTLPAPKQ 453
             G  +C   L +     + LP  ++
Sbjct: 730 RVGECSCQVSLMLQNSSARALPRGRE 755



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 62/220 (28%), Positives = 92/220 (41%), Gaps = 31/220 (14%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P FI  P N+ I EG   + + +V G P P V+W+ NG+ + S     +    +G  SL+
Sbjct: 33  PAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLV 92

Query: 310 FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKR---------------------- 347
              V   D G Y C A N +G    TV+L V     K+                      
Sbjct: 93  IHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETR 152

Query: 348 -------APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQ 400
                   P F  K     V EG   +  C+I+  P P++ W + N  +Q  + R+S+ +
Sbjct: 153 PSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQ-PSARVSVSE 211

Query: 401 DNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
            N G   L I  VN+ D G YT   VN +G  + +  L +
Sbjct: 212 KN-GMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 58/214 (27%), Positives = 96/214 (44%), Gaps = 20/214 (9%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P F  V ++ ++ EG+   +   V G P P ++W LNG+ +Q    +     E G+  L 
Sbjct: 445 PSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQ----YARSTCEAGVAELH 500

Query: 310 FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKR--------------APMFIYKP 355
            +     D G Y C+A+N  G+ + +  + V  K+  R              AP+F+   
Sbjct: 501 IQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGL 560

Query: 356 QSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNK 415
              KV++G  V +  Q+S  PPP++ W  N   +Q + D    ++    + +L I++V  
Sbjct: 561 SDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESED--FHFEQRGTQHSLCIQEVFP 618

Query: 416 KDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLP 449
           +D G YT  A N AG       L V    + T P
Sbjct: 619 EDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQP 652



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 86/416 (20%), Positives = 157/416 (37%), Gaps = 62/416 (14%)

Query: 94   ASFLSSILPSQPDYNSSKIPSAMDSNYQQSSAGQPINAKPSQTANAKPIPRTPD-HEIQG 152
            A+    + P        K+ S    +++   A +  +  P       P P TPD   + G
Sbjct: 858  ANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLG 917

Query: 153  SKEAL--------IQDLERKLKCKDTLLHN----GNQRLTYEEKMARRL--LGPQNAAAV 198
             K+ L         + L  K       L N    G  +     K A  L  +G    A  
Sbjct: 918  GKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAET 977

Query: 199  FQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPEN 258
             +   ++   ++ +  S+    +   + V  +    G  +++   + +   P F Q  ++
Sbjct: 978  LKPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQD 1037

Query: 259  MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKG-LHSLIFEVVRASD 317
            + + EG+   +  +VS  P   + W LNG+T+++     +I+S++G L S+  E     D
Sbjct: 1038 VHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKF--IILSQEGSLCSVSIEKALPED 1095

Query: 318  AGAYACVAKNRAGEATFTVQL---DVLAKEHKRA-------------------------- 348
             G Y CVAKN AG+A  + Q+   D  A E+ +A                          
Sbjct: 1096 RGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKK 1155

Query: 349  -------------PMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDR 395
                         P  I  P+ +KV  G+SV+L  +++   P    W +  + +Q +   
Sbjct: 1156 KPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHM 1215

Query: 396  ISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAP 451
                 +N  ++T+L     ++  G YT+   N+ G       L V  +P+     P
Sbjct: 1216 KVENSENGSKLTILA--ARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTP 1269



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 39/127 (30%), Positives = 60/127 (47%), Gaps = 5/127 (3%)

Query: 223  PTSQVRSRST-SRGDVNDQ--DAIQEK--FYPPRFIQVPENMSIDEGRFCRMDFKVSGLP 277
            PTS + +    S  DV+    +A+ E+     P F +   ++ + EG   R D K+ G P
Sbjct: 1708 PTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYP 1767

Query: 278  APDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQ 337
             P+V W+ + ++++     ++   E G  SLI   V   D   Y C A N  GEAT T +
Sbjct: 1768 DPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAE 1827

Query: 338  LDVLAKE 344
            L V   E
Sbjct: 1828 LIVETME 1834



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 30/104 (28%), Positives = 52/104 (50%), Gaps = 2/104 (1%)

Query: 338  LDVLAKEHKRA-PMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRI 396
            L+ +A+E     P F    +  +V+EG + + +C+I   P P++ W ++++ ++  +   
Sbjct: 1728 LEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIR-ESRHF 1786

Query: 397  SLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
             +  D  G  +L+I DV   D   YT  AVN  G  TC   L V
Sbjct: 1787 QIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIV 1830



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 33/115 (28%), Positives = 54/115 (46%), Gaps = 3/115 (2%)

Query: 348  APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
            AP F  K Q   V EG  + L+CQ+S+ PP  + W  N + ++  T +  +        +
Sbjct: 1028 APAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLK--TTKFIILSQEGSLCS 1085

Query: 408  LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARP-NQTLPAPKQLRVRPTFS 461
            + I+    +D G Y   A N+AG   C+ ++ V   P ++   AP+    RP  S
Sbjct: 1086 VSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSS 1140



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 25/92 (27%), Positives = 42/92 (45%), Gaps = 1/92 (1%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
           PP+F      + + EG+  R   K++G P P V+W L G           +  + G+  L
Sbjct: 160 PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTW-LKGNVPLQPSARVSVSEKNGMQVL 218

Query: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
               V   D G Y C+  N +G+A+ + +L +
Sbjct: 219 EIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 83/375 (22%), Positives = 140/375 (37%), Gaps = 51/375 (13%)

Query: 13   SQNPCGSRLQPPGPETSSFSSQTKQSSIIIQPRQCTEQRFSASSTLSSHITMS----SSA 68
            S+ P   ++ PP P T  F     +S +  + +   E   S++ TL++    S    S+A
Sbjct: 894  SKTPVPEKVPPPKPATPDF-----RSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNA 948

Query: 69   FPASPQQHAG-SNPGQRVTTTYNQSPASFLSSILPSQPDYN-------SSKIPSAMDSNY 120
             P+ P +  G + P + +    N  PA  L  +  ++PD N         K     D N 
Sbjct: 949  QPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNC 1008

Query: 121  QQSSAGQPINAKPSQTANAKPI--PRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQR 178
            ++  AG   N K S++    P    +  D  +   K+ L+Q  +       T++   N +
Sbjct: 1009 KRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQ-CQVSSDPPATIIWTLNGK 1067

Query: 179  LTYEEKM-------------ARRLLGPQNAAAVFQAQDDSG-AQDSQQHNSEHA----RL 220
                 K                + L          A++D+G A+ S Q   + A      
Sbjct: 1068 TLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENT 1127

Query: 221  QVPTSQVRSRSTSRGDV--NDQDAIQEK----------FYPPRFIQVPENMSIDEGRFCR 268
            + P  + R   +S   V   + DA  +K            PP+ IQ PE+  +  G    
Sbjct: 1128 KAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVE 1187

Query: 269  MDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNR 328
            +  KV+G      +W    + +Q  +  K+  SE G   L     R    G Y  + +N+
Sbjct: 1188 LFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENG-SKLTILAARQEHCGCYTLLVENK 1246

Query: 329  AGEATFTVQLDVLAK 343
             G     V L V+ K
Sbjct: 1247 LGSRQAQVNLTVVDK 1261



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 1/93 (1%)

Query: 348 APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
           AP FI  P++  + EG + K E ++   P P++ W RN + +  +  R  L     G  +
Sbjct: 32  APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPIT-SGGRFLLDCGIRGTFS 90

Query: 408 LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV 440
           L+I  V+++D G YT  A N +G       L V
Sbjct: 91  LVIHAVHEEDRGKYTCEATNGSGARQVTVELTV 123



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 40/161 (24%), Positives = 66/161 (40%), Gaps = 16/161 (9%)

Query: 348 APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
           AP F    +   V+EG    L+C +   P P++ W  N + +Q+            G   
Sbjct: 444 APSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTC-----EAGVAE 498

Query: 408 LLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDV-----TARPNQTLPAPKQLRVRPTFSK 462
           L I+D   +D G YT  A N  G  +C+  + V     + +    LP        P F +
Sbjct: 499 LHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQ 558

Query: 463 YLA----LNGK--GLNVKQAFNPEGEFQRLAAQSGLYESEE 497
            L+    ++G    + V+ + NP  E   L   + + ESE+
Sbjct: 559 GLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESED 599


>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
            RhoGEF isoform a [Homo sapiens]
          Length = 6620

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 60/244 (24%), Positives = 110/244 (45%), Gaps = 8/244 (3%)

Query: 200  QAQDDSGAQDSQQHNSEHAR---LQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVP 256
            Q + D  A +  Q   +  R   LQ  T+ ++S          Q      + PP F +  
Sbjct: 5961 QVEGDDRAFEVWQEREDSVRKYLLQARTAIIKSSWVKEICGIQQRLALPVWRPPDFEEEL 6020

Query: 257  ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRAS 316
             + + + G   ++  +V+G P P +SWY +G+ VQ D  H +I    G  +LI + +   
Sbjct: 6021 ADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGV 6080

Query: 317  DAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIP 376
            D+G Y C A + AG  +   ++ V     +  P F+ K ++   +EG+  +  C I   P
Sbjct: 6081 DSGQYMCFAASAAGNCSTLGKILV-----QVPPRFVNKVRASPFVEGEDAQFTCTIEGAP 6135

Query: 377  PPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
             P++ W ++  ++       +L +  +G + L+I+  +K+D G Y    VN  G    + 
Sbjct: 6136 YPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASA 6195

Query: 437  RLDV 440
             L +
Sbjct: 6196 ELRI 6199



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 54/205 (26%), Positives = 90/205 (43%), Gaps = 5/205 (2%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           PRF+  P+   +  G+   +  ++ G P P VSW  + + V +    ++   +  L+ L 
Sbjct: 10  PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRL-AQDGDLYRLT 68

Query: 310 FEVVRASDAGAYACVAKNRAGEATFTV--QLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
              +   D+G Y C A+N  GEA   V  Q+D  A   ++AP F+ +P S +V EG    
Sbjct: 69  ILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEAT 128

Query: 368 LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLL-IKDVNKKDAGWYTVSAV 426
             C++   P P + W ++   +    D   +  +  G  + L I+    +D G Y V A 
Sbjct: 129 FRCRVGGSPRPAVSWSKDGRRLG-EPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAE 187

Query: 427 NEAGVTTCNTRLDVTARPNQTLPAP 451
           N  G  +    L V +    T   P
Sbjct: 188 NPLGAASAAAALVVDSDAADTASRP 212



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 54/212 (25%), Positives = 91/212 (42%), Gaps = 18/212 (8%)

Query: 250  PRFIQVPENMSIDEG-RFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P+ ++   ++ +  G R  +   KV G PAP + W+ +G+ + +   H  +  +K LH+L
Sbjct: 5260 PQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTA-SAHIRMTDKKILHTL 5318

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLA---KEHKRA---------PMFIYKPQ 356
                V   D+G YA    N  G A  + +L V      E K A         P  + +  
Sbjct: 5319 EIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPRMLERFT 5378

Query: 357  SKKVLEGDSVKLECQISAIPPPKLFWKRNNE---MVQFNTDRIS-LYQDNTGRVTLLIKD 412
             KKV +G S+    ++   P P + W R      ++    D        +  + +L++ D
Sbjct: 5379 PKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQHSLVLLD 5438

Query: 413  VNKKDAGWYTVSAVNEAGVTTCNTRLDVTARP 444
            V ++  G YT  A N AG   C+  L V+  P
Sbjct: 5439 VGRQHQGTYTCIASNAAGQALCSASLHVSGLP 5470



 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 51/230 (22%), Positives = 96/230 (41%), Gaps = 48/230 (20%)

Query: 250  PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
            P F+   +N  + +G     D  V+G P P V W+ +G+ ++ DD + +   ++G H LI
Sbjct: 5126 PVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLI 5185

Query: 310  FEVVRASDAGAYACVAKNRAGEATFTVQL--DVLAKEHKRA------------------- 348
               V  +D G Y C+A+N  G ++   +L  D+ + ++  A                   
Sbjct: 5186 ITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSR 5245

Query: 349  --------------PMFIYKPQSKKVLEGDSV-KLECQISAIPPPKLFWKRNNEMVQFN- 392
                          P  + + +  +V  G  + K + ++   P P+L+W ++ + +  + 
Sbjct: 5246 EQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASA 5305

Query: 393  ----TDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 438
                TD+  L+       TL I  V ++D+G Y     N  G    + RL
Sbjct: 5306 HIRMTDKKILH-------TLEIISVTREDSGQYAAYISNAMGAAYSSARL 5348



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 56/212 (26%), Positives = 83/212 (39%), Gaps = 30/212 (14%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P F+  P ++ + EG       +V G P P VSW  +GR +   D  ++ V E G  S +
Sbjct: 110 PHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASAL 169

Query: 310 -FEVVRASDAGAYACVAKNRAGEATFTVQLDVLA-----------------------KEH 345
                R  D G Y   A+N  G A+    L V +                       +E 
Sbjct: 170 RIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREA 229

Query: 346 KRAPMFIYKPQSK-----KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQ 400
            RA      P S       V EG   +L C ++  P P+  WK++ ++V      + +Y+
Sbjct: 230 MRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHV-VYE 288

Query: 401 DNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVT 432
           D      L I    + D G YT +A N  G T
Sbjct: 289 DAQENFVLKILFCKQSDRGLYTCTASNLVGQT 320



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 55/204 (26%), Positives = 85/204 (41%), Gaps = 17/204 (8%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P +FI+   N    EG    +  ++S   A  V W     T++  D H +   +     L
Sbjct: 3713 PSKFIEGLRNEEATEGDTATLWCELS--KAAPVEWRKGHETLRDGDRHSLR-QDGSRCEL 3769

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
                +   DAG Y+CV       AT TV+             FI   ++++  EG +  L
Sbjct: 3770 QIRGLAVVDAGEYSCVCGQERTSATLTVR--------ALPARFIEDVKNQEAREGATAVL 3821

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            +C++S   P +  W++ +E ++   DR SL QD T R  L I  ++  D G Y+     E
Sbjct: 3822 QCELSKAAPVE--WRKGSETLR-GGDRYSLRQDGT-RCELQIHGLSVADTGEYSCVCGQE 3877

Query: 429  AGVTTCNTRL--DVTARPNQTLPA 450
                T   R    V   P Q+L A
Sbjct: 3878 RTSATLTVRAPQPVFREPLQSLQA 3901



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 44/187 (23%), Positives = 82/187 (43%), Gaps = 12/187 (6%)

Query: 257  ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRAS 316
            +++ + EG+      ++S     +  W L G  +Q+++++ + V +  LH L    V   
Sbjct: 4257 QDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITVEQGTLHLLTLHKVTLE 4316

Query: 317  DAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIP 376
            DAG  +       G  +   QL V AK        +   ++ + LEG     ECQ+S   
Sbjct: 4317 DAGTVSF----HVGTCSSEAQLKVTAKN-----TVVRGLENVEALEGGEALFECQLSQPE 4367

Query: 377  PPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSA---VNEAGVTT 433
                 W  ++E V  + +   ++ +N  R  LL+K++  +D+   T  A   V  A +T 
Sbjct: 4368 VAAHTWLLDDEPVHTSENAEVVFFENGLRHLLLLKNLRPQDSCRVTFLAGDMVTSAFLTV 4427

Query: 434  CNTRLDV 440
               RL++
Sbjct: 4428 RGWRLEI 4434



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 53/189 (28%), Positives = 85/189 (44%), Gaps = 15/189 (7%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P +F +   N    EG    +  ++S + AP V W+    T++  D H +          
Sbjct: 3625 PIKFTEGLRNEEATEGATAVLRCELSKM-AP-VEWWKGHETLRDGDRHSLRQDGARCELQ 3682

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
            I  +V A DAG Y C+     G+   +  L V A   K    FI   ++++  EGD+  L
Sbjct: 3683 IRGLV-AEDAGEYLCM----CGKERTSAMLTVRAMPSK----FIEGLRNEEATEGDTATL 3733

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
             C++S   P +  W++ +E ++ + DR SL QD + R  L I+ +   DAG Y+     E
Sbjct: 3734 WCELSKAAPVE--WRKGHETLR-DGDRHSLRQDGS-RCELQIRGLAVVDAGEYSCVCGQE 3789

Query: 429  AGVTTCNTR 437
                T   R
Sbjct: 3790 RTSATLTVR 3798



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 53/213 (24%), Positives = 92/213 (43%), Gaps = 19/213 (8%)

Query: 235  GDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD 294
            GD     A++    P  F +   + +I EG    +  + S    P V W  +G+T++   
Sbjct: 3081 GDQRASAALRVTEKPSVFSRELTDATITEGEDLTLVCETSTCDIP-VCWTKDGKTLRGSA 3139

Query: 295  LHKMIVSEKGLHS-LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIY 353
              +  +S +G  + L+       D+G Y C A      +        + + H R   F  
Sbjct: 3140 --RCQLSHEGHRAQLLITGATLQDSGRYKCEAGGACSSS--------IVRVHARPVRFQE 3189

Query: 354  KPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDV 413
              +  +VLEG +  L C +S++  P  +   NN  V    D+ SL Q+    + L+++++
Sbjct: 3190 ALKDLEVLEGGAATLRCVLSSVAAPVKWCYGNN--VLRPGDKYSLRQEG-AMLELVVRNL 3246

Query: 414  NKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQ 446
              +D+G Y+ S     G  T +  L VTA P Q
Sbjct: 3247 RPQDSGRYSCS----FGDQTTSATLTVTALPAQ 3275



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 49/174 (28%), Positives = 76/174 (43%), Gaps = 17/174 (9%)

Query: 272  KVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGE 331
            +VS   A  V W L G  +QS+++ ++ V +  +H+L  + V   DAG  +    N A  
Sbjct: 4181 EVSRAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASS 4240

Query: 332  ATFTVQLDVLAKEHKRAP-MFIYKP-QSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMV 389
            A  TV          RAP + I +P Q  ++ EG     +C++S     +  W      +
Sbjct: 4241 AQLTV----------RAPEVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPL 4290

Query: 390  QFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTAR 443
            Q N       +  T  +  L K V  +DAG  TVS     G  +   +L VTA+
Sbjct: 4291 QANEMNDITVEQGTLHLLTLHK-VTLEDAG--TVSF--HVGTCSSEAQLKVTAK 4339



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 29/102 (28%), Positives = 52/102 (50%), Gaps = 3/102 (2%)

Query: 348  APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
            AP+F+ + Q+++V +G  V  +C ++  P P + W ++ ++++   D   + +D  G   
Sbjct: 5125 APVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLE-EDDHYMINEDQQGGHQ 5183

Query: 408  LLIKDVNKKDAGWYTVSAVNEAGV--TTCNTRLDVTARPNQT 447
            L+I  V   D G Y   A N  GV  T    R+D+T+    T
Sbjct: 5184 LIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDT 5225



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 59/244 (24%), Positives = 100/244 (40%), Gaps = 24/244 (9%)

Query: 180 TYEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVND 239
           TYE + A   LG  +AAA      D+    S+   S  A L       R R   R +   
Sbjct: 181 TYEVR-AENPLGAASAAAALVVDSDAADTASRPGTSTAALL---AHLQRRREAMRAEGAP 236

Query: 240 QDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMI 299
                    PP         ++ EG+  R+   V+G P P+  W  +G+ V     H  +
Sbjct: 237 AS-------PPS--TGTRTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRH--V 285

Query: 300 VSEKGLHSLIFEVV--RASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQS 357
           V E    + + +++  + SD G Y C A N  G+ T++    VL    + A  F  + Q 
Sbjct: 286 VYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQ-TYS---SVLVVVREPAVPFKKRLQD 341

Query: 358 KKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKD 417
            +V E +S    C++   P  +  W +  E   + + +  + ++ T R  L +++V+  D
Sbjct: 342 LEVREKESATFLCEVPQ-PSTEAAWFK-EETRLWASAKYGIEEEGTER-RLTVRNVSADD 398

Query: 418 AGWY 421
              Y
Sbjct: 399 DAVY 402



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 37/150 (24%), Positives = 73/150 (48%), Gaps = 14/150 (9%)

Query: 280  DVSWYLNGRTVQSDDLHKMIVSEKG-LHSLIFEVVRASDAGAYACVAKNRAGEATFTVQL 338
            +V W LNG  + +D  H+  +S KG  H+L+ + ++ +DAG    + +  + + + + +L
Sbjct: 2587 EVEWSLNGMPLYNDSFHE--ISHKGRRHTLVLKSIQRADAG----IVRASSLKVSTSARL 2640

Query: 339  DVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISL 398
            +V  K      +F+         E  ++ L+C++S  P   + W+++   VQ        
Sbjct: 2641 EVRVK----PVVFLKALDDLSAEERGTLALQCEVSD-PEAHVVWRKDG--VQLGPSDKYD 2693

Query: 399  YQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            +    G   L++ DV+ +DAG YT    +E
Sbjct: 2694 FLHTAGTRGLVVHDVSPEDAGLYTCHVGSE 2723



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 44/190 (23%), Positives = 85/190 (44%), Gaps = 15/190 (7%)

Query: 250  PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
            P F +  +++  +EG    +  ++S  P   V W   G  +Q++   +  + +     L+
Sbjct: 3890 PVFREPLQSLQAEEGSTATLQCELSE-PTATVVWSKGGLQLQANGRREPRL-QGCTAELV 3947

Query: 310  FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPM-FIYKPQSKKVLEGDSVKL 368
             + ++  D G Y C   ++A  AT TV           AP+ F+ + Q ++V EG +  L
Sbjct: 3948 LQDLQREDTGEYTCTCGSQATSATLTV---------TAAPVRFLRELQHQEVDEGGTAHL 3998

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
             C++S      + W R   +  F   +  + QD      LL++ V ++DAG YT    + 
Sbjct: 3999 CCELSR-AGASVEW-RKGSLQLFPCAKYQMVQDGAA-AELLVRGVEQEDAGDYTCDTGHT 4055

Query: 429  AGVTTCNTRL 438
              + + + R+
Sbjct: 4056 QSMASLSVRV 4065



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 34/144 (23%), Positives = 55/144 (38%), Gaps = 7/144 (4%)

Query: 202  QDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSI 261
            ++DSG   +   N+  A     ++++  R     +      + E+  PPR ++      +
Sbjct: 5325 REDSGQYAAYISNAMGAAYS--SARLLVRGPDEPEEKPASDVHEQLVPPRMLERFTPKKV 5382

Query: 262  DEGRFCRMDFKVSGLPAPDVSWYLNGRT-----VQSDDLHKMIVSEKGLHSLIFEVVRAS 316
             +G       KV G P P V W           +  D     + S    HSL+   V   
Sbjct: 5383 KKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQHSLVLLDVGRQ 5442

Query: 317  DAGAYACVAKNRAGEATFTVQLDV 340
              G Y C+A N AG+A  +  L V
Sbjct: 5443 HQGTYTCIASNAAGQALCSASLHV 5466



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 44/200 (22%), Positives = 84/200 (42%), Gaps = 15/200 (7%)

Query: 257  ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRAS 316
            E++ + EG       ++S      V W+L+   + +++L+++     G H L    +   
Sbjct: 3012 EDVDVQEGSSATFRCRISPANYEPVHWFLDKTPLHANELNEIDAQPGGYHVLTLRQLALK 3071

Query: 317  DAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIP 376
            D+G     A ++   A   V         ++  +F  +     + EG+ + L C+ S   
Sbjct: 3072 DSGTIYFEAGDQRASAALRVT--------EKPSVFSRELTDATITEGEDLTLVCETSTCD 3123

Query: 377  PPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
             P + W ++ + ++  + R  L  +   R  LLI     +D+G Y      EAG    ++
Sbjct: 3124 IP-VCWTKDGKTLR-GSARCQLSHEG-HRAQLLITGATLQDSGRYKC----EAGGACSSS 3176

Query: 437  RLDVTARPNQTLPAPKQLRV 456
             + V ARP +   A K L V
Sbjct: 3177 IVRVHARPVRFQEALKDLEV 3196



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 37/113 (32%), Positives = 53/113 (46%), Gaps = 5/113 (4%)

Query: 348 APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQD-NTGRV 406
           AP F+ +P++  V  G    L CQI   P P++ W+++ + V     R  L QD +  R+
Sbjct: 9   APRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGA-RFRLAQDGDLYRL 67

Query: 407 TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPT 459
           T+L  D+   D+G Y   A N  G       L V A       AP  L +RPT
Sbjct: 68  TIL--DLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFL-LRPT 117



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 48/190 (25%), Positives = 78/190 (41%), Gaps = 17/190 (8%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P  FI    +    EG    +  ++S   A  V W     +++  D H +   +  +  L
Sbjct: 3361 PAHFIGRLRHQESIEGATATLRCELS--KAAPVEWRKGRESLRDGDRHSLR-QDGAVCEL 3417

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAP-MFIYKPQSKKVLEGDSVK 367
                +  +DAG Y+CV       AT TV         K  P  F    ++++ +EG +  
Sbjct: 3418 QICGLAVADAGEYSCVCGEERTSATLTV---------KALPAKFTEGLRNEEAVEGATAM 3468

Query: 368  LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
            L C++S + P +  W++  E ++ + DR  L Q+ T R  L I  +   DAG Y      
Sbjct: 3469 LWCELSKVAPVE--WRKGPENLR-DGDRYILRQEGT-RCELQICGLAMADAGEYLCVCGQ 3524

Query: 428  EAGVTTCNTR 437
            E    T   R
Sbjct: 3525 ERTSATLTIR 3534



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 44/157 (28%), Positives = 63/157 (40%), Gaps = 27/157 (17%)

Query: 306  HSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKV-LEGD 364
            ++LI+  V A DAG    VA+N    A   V         K  P+ + +P   K+ +E  
Sbjct: 2255 YTLIYRRVLAEDAGEIQFVAENAESRAQLRV---------KELPVTLVRPLRDKIAMEKH 2305

Query: 365  SVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVS 424
               LECQ+S       ++K + E+      +  L  D   R  L+I DV+ +D   YT  
Sbjct: 2306 RGVLECQVSRASAQVRWFKGSQELQP--GPKYELVSDGLYR-KLIISDVHAEDEDTYTCD 2362

Query: 425  A----------VNEAGVTTCNTRLDVTARPNQTLPAP 451
            A          V E  +T      DVT       PAP
Sbjct: 2363 AGDVKTSAQFFVEEQSITIVRGLQDVTVME----PAP 2395



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 43/172 (25%), Positives = 74/172 (43%), Gaps = 27/172 (15%)

Query: 277  PAPDVSWYLNGRTVQSDDLHKMIVSEKGL-HSLIFEVVRASDAGAYACVAKNRAGEATFT 335
            P  +V+WY +G+ + S    +M V  KG    L+ + V  +DAG Y+C     AG    +
Sbjct: 1193 PQTEVTWYKDGKKLSSSSKVRMEV--KGCTRRLVVQQVGKADAGEYSC----EAGGQRVS 1246

Query: 336  VQLDVLAKEHKRAPMFIYKPQ-----SKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQ 390
             QL      H   P  ++  +       +   G S  L C+++       ++K   ++  
Sbjct: 1247 FQL------HITEPKAVFAKEQLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSS 1300

Query: 391  FNTDRISLYQDNTGRV-TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVT 441
             +  RI    +  G +  L+++   + DAG YT     EAG    +  LDV+
Sbjct: 1301 SSKVRI----EAAGCMRQLVVQQAGQADAGEYTC----EAGGQRLSFHLDVS 1344



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 17/61 (27%), Positives = 28/61 (45%)

Query: 276  LPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFT 335
            +P  + SWY+NG  VQ DD    + ++   H+L+    +   AG      ++    A  T
Sbjct: 4459 VPVGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSAQPHHAGEVTFACRDAVASARLT 4518

Query: 336  V 336
            V
Sbjct: 4519 V 4519



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 36/148 (24%), Positives = 66/148 (44%), Gaps = 15/148 (10%)

Query: 278 APDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQ 337
           A  V+W  +GRT+     +++  S  G   L+   V   DAG Y CV  +R G   + + 
Sbjct: 734 AAAVTWLKDGRTLSPGPKYEVQASA-GRRVLLVRDVARDDAGLYECV--SRGGRIAYQLS 790

Query: 338 LDVLAKEHKRAPMFIYKPQSKKVLE---GDSVKLECQISAIPPPKLFWKRNNEMVQFNTD 394
           +  LA+       F++K  +   ++   G   + EC+ S      + W ++   +  + +
Sbjct: 791 VQGLAR-------FLHKDMAGSCVDAVAGGPAQFECETSE-AHVHVHWYKDGMELGHSGE 842

Query: 395 RISLYQDNTGRVTLLIKDVNKKDAGWYT 422
           R  L +D   R  L+   V ++D G Y+
Sbjct: 843 RF-LQEDVGTRHRLVAATVTRQDEGTYS 869



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 33/127 (25%), Positives = 58/127 (45%), Gaps = 10/127 (7%)

Query: 299  IVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSK 358
            +V+E  + SL    +RA DAG Y C +++    A  TV +  + K       F+    + 
Sbjct: 1856 MVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVK-------FMSGLSTV 1908

Query: 359  KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
               EG     +C +S      + W R+  ++Q  +++ ++ Q      +L I D+  +DA
Sbjct: 1909 VAEEGGEATFQCVVSP-SDVAVVWFRDGALLQ-PSEKFAISQSGASH-SLTISDLVLEDA 1965

Query: 419  GWYTVSA 425
            G  TV A
Sbjct: 1966 GQITVEA 1972



 Score = 37.4 bits (85), Expect = 0.032
 Identities = 24/91 (26%), Positives = 43/91 (47%), Gaps = 3/91 (3%)

Query: 344  EHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNN-EMVQFNTDRISLYQDN 402
            + +  PMF +     +   GD+++LEC +++    +  W ++  E+       I    D 
Sbjct: 4893 KQQEGPMFSHTFGDTEAQVGDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLGDG 4952

Query: 403  TGRVTLLIKDVNKKDAGWYTVSAVNEAGVTT 433
            T   +LLI  +++ DAG YT    N+ G  T
Sbjct: 4953 T--CSLLITGLDRADAGCYTCQVSNKFGQVT 4981



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 33/137 (24%), Positives = 58/137 (42%), Gaps = 10/137 (7%)

Query: 237  VNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLH 296
            V+    ++ +  P  F++  +++S +E     +  +VS  P   V W  +G  +   D +
Sbjct: 2634 VSTSARLEVRVKPVVFLKALDDLSAEERGTLALQCEVSD-PEAHVVWRKDGVQLGPSDKY 2692

Query: 297  KMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQ 356
              + +  G   L+   V   DAG Y C   +    A   V  D+     KR        +
Sbjct: 2693 DFLHTA-GTRGLVVHDVSPEDAGLYTCHVGSEETRARVRVH-DLHVGITKRL-------K 2743

Query: 357  SKKVLEGDSVKLECQIS 373
            + +VLEG+S   EC +S
Sbjct: 2744 TMEVLEGESCSFECVLS 2760



 Score = 33.5 bits (75), Expect = 0.46
 Identities = 45/206 (21%), Positives = 81/206 (39%), Gaps = 18/206 (8%)

Query: 250  PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDV-SWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P+F    +++  + G   R+  ++S   +  V  W   G  + +   ++M  S+     L
Sbjct: 4068 PKFKTRLQSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMR-SQGATREL 4126

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
            +   + A D G YACV   +   A+  V         +     +      +V   + V+ 
Sbjct: 4127 LIHQLEAKDTGEYACVTGGQKTAASLRVT--------EPEVTIVRGLVDAEVTADEDVEF 4178

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV-TLLIKDVNKKDAGWYTVSAVN 427
             C++S      + W      +Q N   ++      GR+ TL +K V  +DAG  +    N
Sbjct: 4179 SCEVSRAGATGVQWCLQGLPLQSN--EVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGN 4236

Query: 428  EAGVTTCNTRLDVTARPNQTLPAPKQ 453
             A     + +L V A P  T+  P Q
Sbjct: 4237 HAS----SAQLTVRA-PEVTILEPLQ 4257



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 28/100 (28%), Positives = 44/100 (44%), Gaps = 3/100 (3%)

Query: 322  ACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLF 381
            A V    AGE     Q   LA+  K  P     P+S++V  G+ V LE ++ A    ++ 
Sbjct: 4597 AAVGPVGAGEPVHLPQTVRLAEPPKPVPPQPSAPESRQVAAGEDVSLELEVVA-EAGEVI 4655

Query: 382  WKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWY 421
            W +  E +Q    R  +      ++ L+IK    +D G Y
Sbjct: 4656 WHKGMERIQ-PGGRFEVVSQGRQQM-LVIKGFTAEDQGEY 4693


>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
            RhoGEF isoform b [Homo sapiens]
          Length = 7968

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 60/244 (24%), Positives = 110/244 (45%), Gaps = 8/244 (3%)

Query: 200  QAQDDSGAQDSQQHNSEHAR---LQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVP 256
            Q + D  A +  Q   +  R   LQ  T+ ++S          Q      + PP F +  
Sbjct: 5961 QVEGDDRAFEVWQEREDSVRKYLLQARTAIIKSSWVKEICGIQQRLALPVWRPPDFEEEL 6020

Query: 257  ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRAS 316
             + + + G   ++  +V+G P P +SWY +G+ VQ D  H +I    G  +LI + +   
Sbjct: 6021 ADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGV 6080

Query: 317  DAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIP 376
            D+G Y C A + AG  +   ++ V     +  P F+ K ++   +EG+  +  C I   P
Sbjct: 6081 DSGQYMCFAASAAGNCSTLGKILV-----QVPPRFVNKVRASPFVEGEDAQFTCTIEGAP 6135

Query: 377  PPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
             P++ W ++  ++       +L +  +G + L+I+  +K+D G Y    VN  G    + 
Sbjct: 6136 YPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASA 6195

Query: 437  RLDV 440
             L +
Sbjct: 6196 ELRI 6199



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 54/205 (26%), Positives = 90/205 (43%), Gaps = 5/205 (2%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           PRF+  P+   +  G+   +  ++ G P P VSW  + + V +    ++   +  L+ L 
Sbjct: 10  PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRL-AQDGDLYRLT 68

Query: 310 FEVVRASDAGAYACVAKNRAGEATFTV--QLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
              +   D+G Y C A+N  GEA   V  Q+D  A   ++AP F+ +P S +V EG    
Sbjct: 69  ILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEAT 128

Query: 368 LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLL-IKDVNKKDAGWYTVSAV 426
             C++   P P + W ++   +    D   +  +  G  + L I+    +D G Y V A 
Sbjct: 129 FRCRVGGSPRPAVSWSKDGRRLG-EPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAE 187

Query: 427 NEAGVTTCNTRLDVTARPNQTLPAP 451
           N  G  +    L V +    T   P
Sbjct: 188 NPLGAASAAAALVVDSDAADTASRP 212



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 54/212 (25%), Positives = 91/212 (42%), Gaps = 18/212 (8%)

Query: 250  PRFIQVPENMSIDEG-RFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P+ ++   ++ +  G R  +   KV G PAP + W+ +G+ + +   H  +  +K LH+L
Sbjct: 5260 PQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTA-SAHIRMTDKKILHTL 5318

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLA---KEHKRA---------PMFIYKPQ 356
                V   D+G YA    N  G A  + +L V      E K A         P  + +  
Sbjct: 5319 EIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPRMLERFT 5378

Query: 357  SKKVLEGDSVKLECQISAIPPPKLFWKRNNE---MVQFNTDRIS-LYQDNTGRVTLLIKD 412
             KKV +G S+    ++   P P + W R      ++    D        +  + +L++ D
Sbjct: 5379 PKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQHSLVLLD 5438

Query: 413  VNKKDAGWYTVSAVNEAGVTTCNTRLDVTARP 444
            V ++  G YT  A N AG   C+  L V+  P
Sbjct: 5439 VGRQHQGTYTCIASNAAGQALCSASLHVSGLP 5470



 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 51/230 (22%), Positives = 96/230 (41%), Gaps = 48/230 (20%)

Query: 250  PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
            P F+   +N  + +G     D  V+G P P V W+ +G+ ++ DD + +   ++G H LI
Sbjct: 5126 PVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLI 5185

Query: 310  FEVVRASDAGAYACVAKNRAGEATFTVQL--DVLAKEHKRA------------------- 348
               V  +D G Y C+A+N  G ++   +L  D+ + ++  A                   
Sbjct: 5186 ITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSR 5245

Query: 349  --------------PMFIYKPQSKKVLEGDSV-KLECQISAIPPPKLFWKRNNEMVQFN- 392
                          P  + + +  +V  G  + K + ++   P P+L+W ++ + +  + 
Sbjct: 5246 EQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASA 5305

Query: 393  ----TDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 438
                TD+  L+       TL I  V ++D+G Y     N  G    + RL
Sbjct: 5306 HIRMTDKKILH-------TLEIISVTREDSGQYAAYISNAMGAAYSSARL 5348



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 56/212 (26%), Positives = 83/212 (39%), Gaps = 30/212 (14%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P F+  P ++ + EG       +V G P P VSW  +GR +   D  ++ V E G  S +
Sbjct: 110 PHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASAL 169

Query: 310 -FEVVRASDAGAYACVAKNRAGEATFTVQLDVLA-----------------------KEH 345
                R  D G Y   A+N  G A+    L V +                       +E 
Sbjct: 170 RIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREA 229

Query: 346 KRAPMFIYKPQSK-----KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQ 400
            RA      P S       V EG   +L C ++  P P+  WK++ ++V      + +Y+
Sbjct: 230 MRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHV-VYE 288

Query: 401 DNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVT 432
           D      L I    + D G YT +A N  G T
Sbjct: 289 DAQENFVLKILFCKQSDRGLYTCTASNLVGQT 320



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 55/204 (26%), Positives = 85/204 (41%), Gaps = 17/204 (8%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P +FI+   N    EG    +  ++S   A  V W     T++  D H +   +     L
Sbjct: 3713 PSKFIEGLRNEEATEGDTATLWCELS--KAAPVEWRKGHETLRDGDRHSLR-QDGSRCEL 3769

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
                +   DAG Y+CV       AT TV+             FI   ++++  EG +  L
Sbjct: 3770 QIRGLAVVDAGEYSCVCGQERTSATLTVR--------ALPARFIEDVKNQEAREGATAVL 3821

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            +C++S   P +  W++ +E ++   DR SL QD T R  L I  ++  D G Y+     E
Sbjct: 3822 QCELSKAAPVE--WRKGSETLR-GGDRYSLRQDGT-RCELQIHGLSVADTGEYSCVCGQE 3877

Query: 429  AGVTTCNTRL--DVTARPNQTLPA 450
                T   R    V   P Q+L A
Sbjct: 3878 RTSATLTVRAPQPVFREPLQSLQA 3901



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 44/187 (23%), Positives = 82/187 (43%), Gaps = 12/187 (6%)

Query: 257  ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRAS 316
            +++ + EG+      ++S     +  W L G  +Q+++++ + V +  LH L    V   
Sbjct: 4257 QDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITVEQGTLHLLTLHKVTLE 4316

Query: 317  DAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIP 376
            DAG  +       G  +   QL V AK        +   ++ + LEG     ECQ+S   
Sbjct: 4317 DAGTVSF----HVGTCSSEAQLKVTAKN-----TVVRGLENVEALEGGEALFECQLSQPE 4367

Query: 377  PPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSA---VNEAGVTT 433
                 W  ++E V  + +   ++ +N  R  LL+K++  +D+   T  A   V  A +T 
Sbjct: 4368 VAAHTWLLDDEPVHTSENAEVVFFENGLRHLLLLKNLRPQDSCRVTFLAGDMVTSAFLTV 4427

Query: 434  CNTRLDV 440
               RL++
Sbjct: 4428 RGWRLEI 4434



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 53/189 (28%), Positives = 85/189 (44%), Gaps = 15/189 (7%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P +F +   N    EG    +  ++S + AP V W+    T++  D H +          
Sbjct: 3625 PIKFTEGLRNEEATEGATAVLRCELSKM-AP-VEWWKGHETLRDGDRHSLRQDGARCELQ 3682

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
            I  +V A DAG Y C+     G+   +  L V A   K    FI   ++++  EGD+  L
Sbjct: 3683 IRGLV-AEDAGEYLCM----CGKERTSAMLTVRAMPSK----FIEGLRNEEATEGDTATL 3733

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
             C++S   P +  W++ +E ++ + DR SL QD + R  L I+ +   DAG Y+     E
Sbjct: 3734 WCELSKAAPVE--WRKGHETLR-DGDRHSLRQDGS-RCELQIRGLAVVDAGEYSCVCGQE 3789

Query: 429  AGVTTCNTR 437
                T   R
Sbjct: 3790 RTSATLTVR 3798



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 53/213 (24%), Positives = 92/213 (43%), Gaps = 19/213 (8%)

Query: 235  GDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD 294
            GD     A++    P  F +   + +I EG    +  + S    P V W  +G+T++   
Sbjct: 3081 GDQRASAALRVTEKPSVFSRELTDATITEGEDLTLVCETSTCDIP-VCWTKDGKTLRGSA 3139

Query: 295  LHKMIVSEKGLHS-LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIY 353
              +  +S +G  + L+       D+G Y C A      +        + + H R   F  
Sbjct: 3140 --RCQLSHEGHRAQLLITGATLQDSGRYKCEAGGACSSS--------IVRVHARPVRFQE 3189

Query: 354  KPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDV 413
              +  +VLEG +  L C +S++  P  +   NN  V    D+ SL Q+    + L+++++
Sbjct: 3190 ALKDLEVLEGGAATLRCVLSSVAAPVKWCYGNN--VLRPGDKYSLRQEG-AMLELVVRNL 3246

Query: 414  NKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQ 446
              +D+G Y+ S     G  T +  L VTA P Q
Sbjct: 3247 RPQDSGRYSCS----FGDQTTSATLTVTALPAQ 3275



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 49/174 (28%), Positives = 76/174 (43%), Gaps = 17/174 (9%)

Query: 272  KVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGE 331
            +VS   A  V W L G  +QS+++ ++ V +  +H+L  + V   DAG  +    N A  
Sbjct: 4181 EVSRAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASS 4240

Query: 332  ATFTVQLDVLAKEHKRAP-MFIYKP-QSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMV 389
            A  TV          RAP + I +P Q  ++ EG     +C++S     +  W      +
Sbjct: 4241 AQLTV----------RAPEVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPL 4290

Query: 390  QFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTAR 443
            Q N       +  T  +  L K V  +DAG  TVS     G  +   +L VTA+
Sbjct: 4291 QANEMNDITVEQGTLHLLTLHK-VTLEDAG--TVSF--HVGTCSSEAQLKVTAK 4339



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 29/102 (28%), Positives = 52/102 (50%), Gaps = 3/102 (2%)

Query: 348  APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT 407
            AP+F+ + Q+++V +G  V  +C ++  P P + W ++ ++++   D   + +D  G   
Sbjct: 5125 APVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLE-EDDHYMINEDQQGGHQ 5183

Query: 408  LLIKDVNKKDAGWYTVSAVNEAGV--TTCNTRLDVTARPNQT 447
            L+I  V   D G Y   A N  GV  T    R+D+T+    T
Sbjct: 5184 LIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDT 5225



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 28/99 (28%), Positives = 50/99 (50%), Gaps = 3/99 (3%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGL-HS 307
            PP      E++    G   + +  + G P P V+WY +  +VQ  D  ++   ++G  +S
Sbjct: 6356 PPSMQVTIEDVQAQTGGTAQFEAIIEGDPQPSVTWYKD--SVQLVDSTRLSQQQEGTTYS 6413

Query: 308  LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHK 346
            L+   V + DAG Y C+A+N  G+     +L VL  +++
Sbjct: 6414 LVLRHVASKDAGVYTCLAQNTGGQVLCKAELLVLGGDNE 6452



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 59/244 (24%), Positives = 100/244 (40%), Gaps = 24/244 (9%)

Query: 180 TYEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVND 239
           TYE + A   LG  +AAA      D+    S+   S  A L       R R   R +   
Sbjct: 181 TYEVR-AENPLGAASAAAALVVDSDAADTASRPGTSTAALL---AHLQRRREAMRAEGAP 236

Query: 240 QDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMI 299
                    PP         ++ EG+  R+   V+G P P+  W  +G+ V     H  +
Sbjct: 237 AS-------PPS--TGTRTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRH--V 285

Query: 300 VSEKGLHSLIFEVV--RASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQS 357
           V E    + + +++  + SD G Y C A N  G+ T++    VL    + A  F  + Q 
Sbjct: 286 VYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQ-TYS---SVLVVVREPAVPFKKRLQD 341

Query: 358 KKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKD 417
            +V E +S    C++   P  +  W +  E   + + +  + ++ T R  L +++V+  D
Sbjct: 342 LEVREKESATFLCEVPQ-PSTEAAWFK-EETRLWASAKYGIEEEGTER-RLTVRNVSADD 398

Query: 418 AGWY 421
              Y
Sbjct: 399 DAVY 402



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 37/150 (24%), Positives = 73/150 (48%), Gaps = 14/150 (9%)

Query: 280  DVSWYLNGRTVQSDDLHKMIVSEKG-LHSLIFEVVRASDAGAYACVAKNRAGEATFTVQL 338
            +V W LNG  + +D  H+  +S KG  H+L+ + ++ +DAG    + +  + + + + +L
Sbjct: 2587 EVEWSLNGMPLYNDSFHE--ISHKGRRHTLVLKSIQRADAG----IVRASSLKVSTSARL 2640

Query: 339  DVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISL 398
            +V  K      +F+         E  ++ L+C++S  P   + W+++   VQ        
Sbjct: 2641 EVRVK----PVVFLKALDDLSAEERGTLALQCEVSD-PEAHVVWRKDG--VQLGPSDKYD 2693

Query: 399  YQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            +    G   L++ DV+ +DAG YT    +E
Sbjct: 2694 FLHTAGTRGLVVHDVSPEDAGLYTCHVGSE 2723



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 35/110 (31%), Positives = 53/110 (48%), Gaps = 4/110 (3%)

Query: 343  KEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTD-RISLYQD 401
            K   RAP F+ +   + V+ G SV L CQ+SA P  +  W ++   ++ ++   IS    
Sbjct: 7457 KSWDRAPTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLK 7516

Query: 402  NTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAP 451
            N   +T+L+  V  +D G YT S  N  G  T    L    RP+ + P P
Sbjct: 7517 NFQLLTILV--VVAEDLGVYTCSVSNALGTVTTTGVLRKAERPSSS-PCP 7563



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 44/190 (23%), Positives = 85/190 (44%), Gaps = 15/190 (7%)

Query: 250  PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
            P F +  +++  +EG    +  ++S  P   V W   G  +Q++   +  + +     L+
Sbjct: 3890 PVFREPLQSLQAEEGSTATLQCELSE-PTATVVWSKGGLQLQANGRREPRL-QGCTAELV 3947

Query: 310  FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPM-FIYKPQSKKVLEGDSVKL 368
             + ++  D G Y C   ++A  AT TV           AP+ F+ + Q ++V EG +  L
Sbjct: 3948 LQDLQREDTGEYTCTCGSQATSATLTV---------TAAPVRFLRELQHQEVDEGGTAHL 3998

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
             C++S      + W R   +  F   +  + QD      LL++ V ++DAG YT    + 
Sbjct: 3999 CCELSR-AGASVEW-RKGSLQLFPCAKYQMVQDGAA-AELLVRGVEQEDAGDYTCDTGHT 4055

Query: 429  AGVTTCNTRL 438
              + + + R+
Sbjct: 4056 QSMASLSVRV 4065



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 34/144 (23%), Positives = 55/144 (38%), Gaps = 7/144 (4%)

Query: 202  QDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSI 261
            ++DSG   +   N+  A     ++++  R     +      + E+  PPR ++      +
Sbjct: 5325 REDSGQYAAYISNAMGAAYS--SARLLVRGPDEPEEKPASDVHEQLVPPRMLERFTPKKV 5382

Query: 262  DEGRFCRMDFKVSGLPAPDVSWYLNGRT-----VQSDDLHKMIVSEKGLHSLIFEVVRAS 316
             +G       KV G P P V W           +  D     + S    HSL+   V   
Sbjct: 5383 KKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQHSLVLLDVGRQ 5442

Query: 317  DAGAYACVAKNRAGEATFTVQLDV 340
              G Y C+A N AG+A  +  L V
Sbjct: 5443 HQGTYTCIASNAAGQALCSASLHV 5466



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 44/200 (22%), Positives = 84/200 (42%), Gaps = 15/200 (7%)

Query: 257  ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRAS 316
            E++ + EG       ++S      V W+L+   + +++L+++     G H L    +   
Sbjct: 3012 EDVDVQEGSSATFRCRISPANYEPVHWFLDKTPLHANELNEIDAQPGGYHVLTLRQLALK 3071

Query: 317  DAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIP 376
            D+G     A ++   A   V         ++  +F  +     + EG+ + L C+ S   
Sbjct: 3072 DSGTIYFEAGDQRASAALRVT--------EKPSVFSRELTDATITEGEDLTLVCETSTCD 3123

Query: 377  PPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNT 436
             P + W ++ + ++  + R  L  +   R  LLI     +D+G Y      EAG    ++
Sbjct: 3124 IP-VCWTKDGKTLR-GSARCQLSHEG-HRAQLLITGATLQDSGRYKC----EAGGACSSS 3176

Query: 437  RLDVTARPNQTLPAPKQLRV 456
             + V ARP +   A K L V
Sbjct: 3177 IVRVHARPVRFQEALKDLEV 3196



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 37/113 (32%), Positives = 53/113 (46%), Gaps = 5/113 (4%)

Query: 348 APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQD-NTGRV 406
           AP F+ +P++  V  G    L CQI   P P++ W+++ + V     R  L QD +  R+
Sbjct: 9   APRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGA-RFRLAQDGDLYRL 67

Query: 407 TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPT 459
           T+L  D+   D+G Y   A N  G       L V A       AP  L +RPT
Sbjct: 68  TIL--DLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFL-LRPT 117



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 36/133 (27%), Positives = 57/133 (42%), Gaps = 5/133 (3%)

Query: 331  EATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQ 390
            + T+T Q   +     R P      +  +   G + + E  I   P P + W +++  + 
Sbjct: 6341 QRTYTYQ--AIDTHTARPPSMQVTIEDVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLV 6398

Query: 391  FNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPA 450
             +T R+S  Q+ T   +L+++ V  KDAG YT  A N  G   C   L V    N+   +
Sbjct: 6399 DST-RLSQQQEGT-TYSLVLRHVASKDAGVYTCLAQNTGGQVLCKAELLVLGGDNEP-DS 6455

Query: 451  PKQLRVRPTFSKY 463
             KQ   R   S Y
Sbjct: 6456 EKQSHRRKLHSFY 6468



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 48/190 (25%), Positives = 78/190 (41%), Gaps = 17/190 (8%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P  FI    +    EG    +  ++S   A  V W     +++  D H +   +  +  L
Sbjct: 3361 PAHFIGRLRHQESIEGATATLRCELS--KAAPVEWRKGRESLRDGDRHSLR-QDGAVCEL 3417

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAP-MFIYKPQSKKVLEGDSVK 367
                +  +DAG Y+CV       AT TV         K  P  F    ++++ +EG +  
Sbjct: 3418 QICGLAVADAGEYSCVCGEERTSATLTV---------KALPAKFTEGLRNEEAVEGATAM 3468

Query: 368  LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
            L C++S + P +  W++  E ++ + DR  L Q+ T R  L I  +   DAG Y      
Sbjct: 3469 LWCELSKVAPVE--WRKGPENLR-DGDRYILRQEGT-RCELQICGLAMADAGEYLCVCGQ 3524

Query: 428  EAGVTTCNTR 437
            E    T   R
Sbjct: 3525 ERTSATLTIR 3534



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 44/157 (28%), Positives = 63/157 (40%), Gaps = 27/157 (17%)

Query: 306  HSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKV-LEGD 364
            ++LI+  V A DAG    VA+N    A   V         K  P+ + +P   K+ +E  
Sbjct: 2255 YTLIYRRVLAEDAGEIQFVAENAESRAQLRV---------KELPVTLVRPLRDKIAMEKH 2305

Query: 365  SVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVS 424
               LECQ+S       ++K + E+      +  L  D   R  L+I DV+ +D   YT  
Sbjct: 2306 RGVLECQVSRASAQVRWFKGSQELQP--GPKYELVSDGLYR-KLIISDVHAEDEDTYTCD 2362

Query: 425  A----------VNEAGVTTCNTRLDVTARPNQTLPAP 451
            A          V E  +T      DVT       PAP
Sbjct: 2363 AGDVKTSAQFFVEEQSITIVRGLQDVTVME----PAP 2395



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 43/172 (25%), Positives = 74/172 (43%), Gaps = 27/172 (15%)

Query: 277  PAPDVSWYLNGRTVQSDDLHKMIVSEKGL-HSLIFEVVRASDAGAYACVAKNRAGEATFT 335
            P  +V+WY +G+ + S    +M V  KG    L+ + V  +DAG Y+C     AG    +
Sbjct: 1193 PQTEVTWYKDGKKLSSSSKVRMEV--KGCTRRLVVQQVGKADAGEYSC----EAGGQRVS 1246

Query: 336  VQLDVLAKEHKRAPMFIYKPQ-----SKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQ 390
             QL      H   P  ++  +       +   G S  L C+++       ++K   ++  
Sbjct: 1247 FQL------HITEPKAVFAKEQLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSS 1300

Query: 391  FNTDRISLYQDNTGRV-TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVT 441
             +  RI    +  G +  L+++   + DAG YT     EAG    +  LDV+
Sbjct: 1301 SSKVRI----EAAGCMRQLVVQQAGQADAGEYTC----EAGGQRLSFHLDVS 1344



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 23/86 (26%), Positives = 37/86 (43%)

Query: 250  PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
            P F++   + ++  G+   +  +VS  PA   +W  +G  ++S     +  + K    L 
Sbjct: 7463 PTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLT 7522

Query: 310  FEVVRASDAGAYACVAKNRAGEATFT 335
              VV A D G Y C   N  G  T T
Sbjct: 7523 ILVVVAEDLGVYTCSVSNALGTVTTT 7548



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 17/61 (27%), Positives = 28/61 (45%)

Query: 276  LPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFT 335
            +P  + SWY+NG  VQ DD    + ++   H+L+    +   AG      ++    A  T
Sbjct: 4459 VPVGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSAQPHHAGEVTFACRDAVASARLT 4518

Query: 336  V 336
            V
Sbjct: 4519 V 4519



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 36/148 (24%), Positives = 66/148 (44%), Gaps = 15/148 (10%)

Query: 278 APDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQ 337
           A  V+W  +GRT+     +++  S  G   L+   V   DAG Y CV  +R G   + + 
Sbjct: 734 AAAVTWLKDGRTLSPGPKYEVQASA-GRRVLLVRDVARDDAGLYECV--SRGGRIAYQLS 790

Query: 338 LDVLAKEHKRAPMFIYKPQSKKVLE---GDSVKLECQISAIPPPKLFWKRNNEMVQFNTD 394
           +  LA+       F++K  +   ++   G   + EC+ S      + W ++   +  + +
Sbjct: 791 VQGLAR-------FLHKDMAGSCVDAVAGGPAQFECETSE-AHVHVHWYKDGMELGHSGE 842

Query: 395 RISLYQDNTGRVTLLIKDVNKKDAGWYT 422
           R  L +D   R  L+   V ++D G Y+
Sbjct: 843 RF-LQEDVGTRHRLVAATVTRQDEGTYS 869



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 33/127 (25%), Positives = 58/127 (45%), Gaps = 10/127 (7%)

Query: 299  IVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSK 358
            +V+E  + SL    +RA DAG Y C +++    A  TV +  + K       F+    + 
Sbjct: 1856 MVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVK-------FMSGLSTV 1908

Query: 359  KVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDA 418
               EG     +C +S      + W R+  ++Q  +++ ++ Q      +L I D+  +DA
Sbjct: 1909 VAEEGGEATFQCVVSP-SDVAVVWFRDGALLQ-PSEKFAISQSGASH-SLTISDLVLEDA 1965

Query: 419  GWYTVSA 425
            G  TV A
Sbjct: 1966 GQITVEA 1972



 Score = 37.4 bits (85), Expect = 0.032
 Identities = 24/91 (26%), Positives = 43/91 (47%), Gaps = 3/91 (3%)

Query: 344  EHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNN-EMVQFNTDRISLYQDN 402
            + +  PMF +     +   GD+++LEC +++    +  W ++  E+       I    D 
Sbjct: 4893 KQQEGPMFSHTFGDTEAQVGDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLGDG 4952

Query: 403  TGRVTLLIKDVNKKDAGWYTVSAVNEAGVTT 433
            T   +LLI  +++ DAG YT    N+ G  T
Sbjct: 4953 T--CSLLITGLDRADAGCYTCQVSNKFGQVT 4981



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 33/137 (24%), Positives = 58/137 (42%), Gaps = 10/137 (7%)

Query: 237  VNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLH 296
            V+    ++ +  P  F++  +++S +E     +  +VS  P   V W  +G  +   D +
Sbjct: 2634 VSTSARLEVRVKPVVFLKALDDLSAEERGTLALQCEVSD-PEAHVVWRKDGVQLGPSDKY 2692

Query: 297  KMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQ 356
              + +  G   L+   V   DAG Y C   +    A   V  D+     KR        +
Sbjct: 2693 DFLHTA-GTRGLVVHDVSPEDAGLYTCHVGSEETRARVRVH-DLHVGITKRL-------K 2743

Query: 357  SKKVLEGDSVKLECQIS 373
            + +VLEG+S   EC +S
Sbjct: 2744 TMEVLEGESCSFECVLS 2760



 Score = 33.5 bits (75), Expect = 0.46
 Identities = 45/206 (21%), Positives = 81/206 (39%), Gaps = 18/206 (8%)

Query: 250  PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDV-SWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            P+F    +++  + G   R+  ++S   +  V  W   G  + +   ++M  S+     L
Sbjct: 4068 PKFKTRLQSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMR-SQGATREL 4126

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
            +   + A D G YACV   +   A+  V         +     +      +V   + V+ 
Sbjct: 4127 LIHQLEAKDTGEYACVTGGQKTAASLRVT--------EPEVTIVRGLVDAEVTADEDVEF 4178

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV-TLLIKDVNKKDAGWYTVSAVN 427
             C++S      + W      +Q N   ++      GR+ TL +K V  +DAG  +    N
Sbjct: 4179 SCEVSRAGATGVQWCLQGLPLQSN--EVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGN 4236

Query: 428  EAGVTTCNTRLDVTARPNQTLPAPKQ 453
             A     + +L V A P  T+  P Q
Sbjct: 4237 HAS----SAQLTVRA-PEVTILEPLQ 4257



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 28/100 (28%), Positives = 44/100 (44%), Gaps = 3/100 (3%)

Query: 322  ACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLF 381
            A V    AGE     Q   LA+  K  P     P+S++V  G+ V LE ++ A    ++ 
Sbjct: 4597 AAVGPVGAGEPVHLPQTVRLAEPPKPVPPQPSAPESRQVAAGEDVSLELEVVA-EAGEVI 4655

Query: 382  WKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWY 421
            W +  E +Q    R  +      ++ L+IK    +D G Y
Sbjct: 4656 WHKGMERIQ-PGGRFEVVSQGRQQM-LVIKGFTAEDQGEY 4693


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score = 90.5 bits (223), Expect = 3e-18
 Identities = 64/216 (29%), Positives = 105/216 (48%), Gaps = 22/216 (10%)

Query: 257  ENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRA- 315
            EN+++    F  +  +VSG P PD+SW  N + ++ +    ++   + L     +++RA 
Sbjct: 2972 ENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTL-----QIIRAK 3026

Query: 316  -SDAGAYACVAKNRAGEA----TFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLEC 370
             SD G Y C+A N+AGE+    + TV +    K+H    + +       V EG SV LEC
Sbjct: 3027 VSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVN-----VREGTSVSLEC 3081

Query: 371  QISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
            + +A+PPP + W +N  M+  +T  + +  D      L IK     D G Y   A+N AG
Sbjct: 3082 ESNAVPPPVITWYKNGRMITEST-HVEILADGQ---MLHIKKAEVSDTGQYVCRAINVAG 3137

Query: 431  VTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLAL 466
                N  L+V   P  ++  P++  +  T S  + L
Sbjct: 3138 RDDKNFHLNVYVPP--SIEGPEREVIVETISNPVTL 3171



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 58/193 (30%), Positives = 95/193 (49%), Gaps = 15/193 (7%)

Query: 255  VPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVR 314
            +PE +++   +   ++   SG PAP  SW  +G+ +  DD HK + + + L  L  ++  
Sbjct: 2878 LPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQI-- 2935

Query: 315  ASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKK--VLEGDSVKLECQI 372
             +D G Y CVA+N AG A     L+V        P  +  P+S+   V+  + + L C++
Sbjct: 2936 -TDIGRYVCVAENTAGSAKKYFNLNV------HVPPSVIGPKSENLTVVVNNFISLTCEV 2988

Query: 373  SAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVT 432
            S  PPP L W +N + ++ NT+ + +     G  TL I      D G YT  A+N+AG +
Sbjct: 2989 SGFPPPDLSWLKNEQPIKLNTNTLIV----PGGRTLQIIRAKVSDGGEYTCIAINQAGES 3044

Query: 433  TCNTRLDVTARPN 445
                 L V   P+
Sbjct: 3045 KKKFSLTVYVPPS 3057



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 56/182 (30%), Positives = 87/182 (47%), Gaps = 14/182 (7%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PPR      + +++E     +     G+P P ++W  +   + ++ L K      G   L
Sbjct: 4168 PPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDN-VLLANLLGKYTAEPYG--EL 4224

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
            I E V   D+G Y CVA N AGE T TV L V        P F   P    + +G+ ++L
Sbjct: 4225 ILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHV-----LPTFTELPGDVSLNKGEQLRL 4279

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
             C+ + IP PKL W  NN ++  + D ++      G   L+I+ V+K+D+G Y  +A N 
Sbjct: 4280 SCKATGIPLPKLTWTFNNNIIPAHFDSVN------GHSELVIERVSKEDSGTYVCTAENS 4333

Query: 429  AG 430
             G
Sbjct: 4334 VG 4335



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 63/238 (26%), Positives = 108/238 (45%), Gaps = 19/238 (7%)

Query: 218  ARLQVPTSQVRSRSTSRGDVNDQDAIQEKFY------PPRFI--QVPENMSIDEGRFCRM 269
            ++LQ+  SQ           ++ +   +K+Y      PP     ++P ++S+  G    +
Sbjct: 3207 SKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVEL 3266

Query: 270  DFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRA 329
                +G+P P + W  +G+ + S +  ++ VS  G    I+  +  SD G Y CVA N A
Sbjct: 3267 VCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGAL-TSDTGKYTCVATNPA 3325

Query: 330  GEATFTVQLDVLAKEHKRAPMFIYKPQSKKV--LEGDSVKLECQISAIPPPKLFWKRNNE 387
            GE      L+V      R      K +++K+  L   S+ +EC+ +  PPP++ W +N  
Sbjct: 3326 GEEDRIFNLNVYVTPTIRG----NKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGL 3381

Query: 388  MVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPN 445
             +  ++  I L     G+V  +++     D   YT  A N AGV   +  L V A PN
Sbjct: 3382 PLPLSS-HIRLLA--AGQVIRIVR-AQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPN 3435



 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 57/194 (29%), Positives = 87/194 (44%), Gaps = 12/194 (6%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P+ + V   + +  G    M+ K SG+P P V W+     ++       ++ +  L  L 
Sbjct: 702 PKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTF---LIIDPLLGLLK 758

Query: 310 FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLE 369
            +  +  DAG Y CVA N AG AT  + LDV +      P+FI +P    +  G +V L 
Sbjct: 759 IQETQDLDAGDYTCVAINEAGRATGKITLDVGSP-----PVFIQEPADVSMEIGSNVTLP 813

Query: 370 CQISAIPPPKLFWKRNNEMVQFNT--DRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
           C +   P P + W+R + M  F+      S+ Q  TG   L I ++   D G Y   A N
Sbjct: 814 CYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTG--ALFILNLWASDKGTYICEAEN 871

Query: 428 EAGVTTCNTRLDVT 441
           + G     T + VT
Sbjct: 872 QFGKIQSETTVTVT 885



 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 54/190 (28%), Positives = 87/190 (45%), Gaps = 13/190 (6%)

Query: 259  MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDA 318
            +++ EG    +  + SG+P P++ W   G  V +D + ++ +   G   L   +   SDA
Sbjct: 2206 LTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGG-RQLQISIAEKSDA 2264

Query: 319  GAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYK---PQSKKVLEGDSVKLECQISAI 375
              Y+CVA N AG A     L V  +     P        P    V  G S+ LEC++  I
Sbjct: 2265 ALYSCVASNVAGTAKKEYNLQVYIR-----PTITNSGSHPTEIIVTRGKSISLECEVQGI 2319

Query: 376  PPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCN 435
            PPP + W ++   +      + +  +  G + L +K+++  D G Y   AVN AG+T   
Sbjct: 2320 PPPTVTWMKDGHPL-IKAKGVEILDE--GHI-LQLKNIHVSDTGRYVCVAVNVAGMTDKK 2375

Query: 436  TRLDVTARPN 445
              L V A P+
Sbjct: 2376 YDLSVHAPPS 2385



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 55/196 (28%), Positives = 85/196 (43%), Gaps = 13/196 (6%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
           PP+   +P+N S   G    +    +G P P ++W +N   +     H+  ++  G  +L
Sbjct: 611 PPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGS--HRYRMTSDG--TL 666

Query: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
             +     DAG Y C+A N AG       L  +      AP  +       V  GD   +
Sbjct: 667 FIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYI-----EAPKLMVVQSELLVALGDITVM 721

Query: 369 ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
           EC+ S IPPP++ W + +  ++       +     G   L I++    DAG YT  A+NE
Sbjct: 722 ECKTSGIPPPQVKWFKGD--LELRPSTFLIIDPLLG--LLKIQETQDLDAGDYTCVAINE 777

Query: 429 AGVTTCNTRLDVTARP 444
           AG  T    LDV + P
Sbjct: 778 AGRATGKITLDVGSPP 793



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 57/201 (28%), Positives = 90/201 (44%), Gaps = 18/201 (8%)

Query: 250  PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
            P F ++P ++S+++G   R+  K +G+P P ++W  N   + +        S  G   L+
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAH-----FDSVNGHSELV 4314

Query: 310  FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFI--YKPQSKKVLEGDSVK 367
             E V   D+G Y C A+N  G       + V     K  P+F   Y     + L G+++ 
Sbjct: 4315 IERVSKEDSGTYVCTAENSVGFVKAIGFVYV-----KEPPVFKGDYPSNWIEPLGGNAI- 4368

Query: 368  LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
            L C++   P P + W R    ++     IS      G  +L I     +DAG YT  A N
Sbjct: 4369 LNCEVKGDPTPTIQWNRKGVDIE-----ISHRIRQLGNGSLAIYGTVNEDAGDYTCVATN 4423

Query: 428  EAGVTTCNTRLDVTARPNQTL 448
            EAGV   +  L + + P  TL
Sbjct: 4424 EAGVVERSMSLTLQSPPIITL 4444



 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 56/182 (30%), Positives = 90/182 (49%), Gaps = 14/182 (7%)

Query: 256  PENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRA 315
            P+ + I       ++ +   +P+  +SWY +G+ ++SDD H  I +    H+L  +  + 
Sbjct: 2681 PKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDD-HVNIAANG--HTLQIKEAQI 2737

Query: 316  SDAGAYACVAKNRAG--EATFTVQLDVLAKEHKRAPMFIY-----KPQSKKVLEGDSVKL 368
            SD G Y CVA N AG  E  F V + V     K   +          ++K V+  + + L
Sbjct: 2738 SDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISL 2797

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
             C+ +A PPP L W ++   +  ++D++ +     GRV L I     +DAG YT  AVNE
Sbjct: 2798 YCETNAAPPPTLTWYKDGHPLT-SSDKVLILPG--GRV-LQIPRAKVEDAGRYTCVAVNE 2853

Query: 429  AG 430
            AG
Sbjct: 2854 AG 2855



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 56/202 (27%), Positives = 87/202 (43%), Gaps = 11/202 (5%)

Query: 259  MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDA 318
            +S  EG    +  K SG P P V W   G  + +    K      G  SL        ++
Sbjct: 990  LSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSA-KFSAGADG--SLYVVSPGGEES 1046

Query: 319  GAYACVAKNRAGEATFTVQLDVLAKEH---KRAPMFIYKPQSKKVLEGDSVKLECQISAI 375
            G Y C A N AG A   VQL V  +      +  +   KP    VL G+ V L C++ ++
Sbjct: 1047 GEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSL 1106

Query: 376  PPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCN 435
            PPP + W +  +++   + R +     + ++T    +    D+G Y   A N AG  T  
Sbjct: 1107 PPPIITWAKETQLISPFSPRHTFLPSGSMKIT----ETRTSDSGMYLCVATNIAGNVTQA 1162

Query: 436  TRLDVTARPNQTLPAPKQLRVR 457
             +L+V   P +    PK L+V+
Sbjct: 1163 VKLNVHV-PPKIQRGPKHLKVQ 1183



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 65/262 (24%), Positives = 108/262 (41%), Gaps = 25/262 (9%)

Query: 220  LQVPTSQVRSR-------STSRGDVNDQDAIQEKFYPPRFIQV--PENMSIDEGRFCRMD 270
            L++ T+QV          S+  GD +D++ +     PP       P ++++   R   ++
Sbjct: 3584 LRISTAQVEDTGRYTCLASSPAGD-DDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLE 3642

Query: 271  FKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAG 330
             K   +P P ++W  NG  +Q+    +++    G   L        D   Y CVA N AG
Sbjct: 3643 CKSDAVPPPVITWLRNGERLQATPRVRIL---SGGRYLQINNADLGDTANYTCVASNIAG 3699

Query: 331  EATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQ 390
            + T    L V    + +       PQS  +L   S  LEC    +P P++ W+++  ++ 
Sbjct: 3700 KTTREFILTVNVPPNIKGG-----PQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLA 3754

Query: 391  FNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTAR-PNQTLP 449
             N  R S+ ++      L I+  +  D G Y   A N AG  T   R+D+    P    P
Sbjct: 3755 GNHARYSILENG----FLHIQSAHVTDTGRYLCMATNAAG--TDRRRIDLQVHVPPSIAP 3808

Query: 450  APKQLRVRPTFSKYLALNGKGL 471
             P  + V       LA    G+
Sbjct: 3809 GPTNMTVIVNVQTTLACEATGI 3830



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 55/199 (27%), Positives = 89/199 (44%), Gaps = 13/199 (6%)

Query: 249  PPRFI---QVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGL 305
            PP  I   + PEN+S+ E     +  + SG+P P ++W+ +G  V   +  +++    G 
Sbjct: 2383 PPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRIL---SGG 2439

Query: 306  HSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDS 365
              L        DAG Y CV +N AGE      L VL   H      +   +  KV E  S
Sbjct: 2440 RMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTL---EDVKVKEKQS 2496

Query: 366  VKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSA 425
            V L C+++  P P++ W ++ + +Q +      +   +G   L I +V     G YT  A
Sbjct: 2497 VTLTCEVTGNPVPEITWHKDGQPLQED----EAHHIISGGRFLQITNVQVPHTGRYTCLA 2552

Query: 426  VNEAGVTTCNTRLDVTARP 444
             + AG  + +  L+V   P
Sbjct: 2553 SSPAGHKSRSFSLNVFVSP 2571



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 56/175 (32%), Positives = 80/175 (45%), Gaps = 16/175 (9%)

Query: 274  SGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEAT 333
            SG+PAP ++W  +GR +   D    + +  G   L     +  D G Y C+A + AG+  
Sbjct: 3553 SGIPAPKMTWMKDGRPLPQTD---QVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDD- 3608

Query: 334  FTVQLDVLAKEHKRAPMFIY---KPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQ 390
                 + L + H   P  I    +P+   VL    V LEC+  A+PPP + W RN E +Q
Sbjct: 3609 ---DKEYLVRVH--VPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQ 3663

Query: 391  FNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPN 445
              T R+ +    +G   L I + +  D   YT  A N AG TT    L V   PN
Sbjct: 3664 -ATPRVRIL---SGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPN 3714



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 55/197 (27%), Positives = 87/197 (44%), Gaps = 15/197 (7%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP     P  + +       +  + +G P+P ++W   G  V +   +  ++   GL   
Sbjct: 3987 PPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQ-- 4044

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDS-VK 367
            I   VR  DAG Y CVA+N AG A   ++L+V      + P  I     + V+  D  + 
Sbjct: 4045 ISRAVR-EDAGTYMCVAQNPAGTALGKIKLNV------QVPPVISPHLKEYVIAVDKPIT 4097

Query: 368  LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
            L C+   +PPP + W ++   +       S+ Q      +L I  V   DAG YT  A N
Sbjct: 4098 LSCEADGLPPPDITWHKDGRAIV-----ESIRQRVLSSGSLQIAFVQPGDAGHYTCMAAN 4152

Query: 428  EAGVTTCNTRLDVTARP 444
             AG ++ +T+L V   P
Sbjct: 4153 VAGSSSTSTKLTVHVPP 4169



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 52/196 (26%), Positives = 78/196 (39%), Gaps = 6/196 (3%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP+  + P+++ +  G+   +     G P P ++W   G T+  D  H +   +    +L
Sbjct: 1170 PPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTL 1226

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
              +    SDAG Y CVA N AG     + L V            Y    ++ +    ++ 
Sbjct: 1227 SIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEF 1286

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
             C     P P + W  N   +      IS+ +D T    L+I  V   D G Y   AVNE
Sbjct: 1287 PCPAKGTPKPTIKWLHNGRELTGREPGISILEDGT---LLVIASVTPYDNGEYICVAVNE 1343

Query: 429  AGVTTCNTRLDVTARP 444
            AG T     L V   P
Sbjct: 1344 AGTTERKYNLKVHVPP 1359



 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 54/198 (27%), Positives = 87/198 (43%), Gaps = 16/198 (8%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
           PP  IQVP N+++  G    +   +      +++W  N R V+  +  ++    + L +L
Sbjct: 519 PPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARI----RTLANL 574

Query: 309 IFEV--VRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSV 366
             E+  V+ +DAG Y C+  +  G +  +V L V     +  P     P+++    G  V
Sbjct: 575 SLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTV-----QEPPKVTVMPKNQSFTGGSEV 629

Query: 367 KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAV 426
            + C  +  P PK+ W   N+M    + R  +  D     TL IK+   KDAG Y   A 
Sbjct: 630 SIMCSATGYPKPKIAW-TVNDMFIVGSHRYRMTSDG----TLFIKNAAPKDAGIYGCLAS 684

Query: 427 NEAGVTTCNTRLDVTARP 444
           N AG    N+ L     P
Sbjct: 685 NSAGTDKQNSTLRYIEAP 702



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 52/183 (28%), Positives = 87/183 (47%), Gaps = 22/183 (12%)

Query: 269  MDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNR 328
            +D  V+G P P + W  +G+ +   D  K++++ +    L+    + S+ G Y C+A N 
Sbjct: 1754 LDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGR---KLVIAQAQVSNTGLYRCMAANT 1810

Query: 329  AG------EATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFW 382
            AG      E T  V   + +       +  YKP          V L+C  + IP P + W
Sbjct: 1811 AGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKP----------VALQCIANGIPNPSITW 1860

Query: 383  KRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTA 442
             ++++ V  NT + +L   ++GRV  + K +  +DAG YT  A N AG T  + +L V  
Sbjct: 1861 LKDDQPV--NTAQGNLKIQSSGRVLQIAKTL-LEDAGRYTCVATNAAGETQQHIQLHVHE 1917

Query: 443  RPN 445
             P+
Sbjct: 1918 PPS 1920



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 50/176 (28%), Positives = 80/176 (45%), Gaps = 13/176 (7%)

Query: 272  KVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGE 331
            +  GLP PD++W+ +GR +      +++ S     SL    V+  DAG Y C+A N AG 
Sbjct: 4101 EADGLPPPDITWHKDGRAIVESIRQRVLSSG----SLQIAFVQPGDAGHYTCMAANVAGS 4156

Query: 332  ATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQF 391
            ++ + +L V      R+    Y      V E     L C    IP P + WK++N ++  
Sbjct: 4157 SSTSTKLTVHVPPRIRSTEGHYT-----VNENSQAILPCVADGIPTPAINWKKDNVLLAN 4211

Query: 392  NTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQT 447
               + +          L++++V  +D+G+YT  A N AG  T    L V   P  T
Sbjct: 4212 LLGKYTAEPYGE----LILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFT 4263



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 62/202 (30%), Positives = 90/202 (44%), Gaps = 18/202 (8%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSW-YLNGRTVQSDDLHKMIVSEKGLHS 307
           PP FIQ P ++S++ G    +   V G P P + W  L+   + S       +S+    +
Sbjct: 792 PPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGA 851

Query: 308 LIFEVVRASDAGAYACVAKNRAG----EATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEG 363
           L    + ASD G Y C A+N+ G    E T TV   V       AP+    P    V+EG
Sbjct: 852 LFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLV-------APLIGISPSVANVIEG 904

Query: 364 DSVKLECQISA-IPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
             + L C + A  P P+  W +N+ M+  N   I++  D     +L I+ V  +D G YT
Sbjct: 905 QQLTLPCTLLAGNPIPERRWIKNSAMLLQN-PYITVRSDG----SLHIERVQLQDGGEYT 959

Query: 423 VSAVNEAGVTTCNTRLDVTARP 444
             A N AG     T + V   P
Sbjct: 960 CVASNVAGTNNKTTSVVVHVLP 981



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 53/180 (29%), Positives = 82/180 (45%), Gaps = 15/180 (8%)

Query: 268  RMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKN 327
            +++ K +G P P ++WY + R +       M    +G   +  E  + SDAG Y CVA N
Sbjct: 1939 QLECKAAGNPVPVITWYKDNRLLSGST--SMTFLNRG-QIIDIESAQISDAGIYKCVAIN 1995

Query: 328  RAG--EATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRN 385
             AG  E  +++Q+ V       AP          V+  + V+LEC+   IP P L W ++
Sbjct: 1996 SAGATELFYSLQVHV-------APSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKD 2048

Query: 386  NEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPN 445
               V   ++ + +   + GR+ L +      D G YT  AVN AG    +  L V   PN
Sbjct: 2049 GSPVSSFSNGLQVL--SGGRI-LALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPN 2105



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 46/184 (25%), Positives = 83/184 (45%), Gaps = 9/184 (4%)

Query: 249  PPRFI--QVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLH 306
            PP  +     E++ + E +   +  +V+G P P+++W+ +G+ +Q D+ H +I    G  
Sbjct: 2477 PPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHII---SGGR 2533

Query: 307  SLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSV 366
             L    V+    G Y C+A + AG  + +  L+V              P+   V+     
Sbjct: 2534 FLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPT 2593

Query: 367  KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAV 426
             L C+  + PP  + W ++   ++ N +   L     G  TL I +  + +AG Y+  A 
Sbjct: 2594 SLVCEAYSYPPATITWFKDGTPLESNRNIRIL----PGGRTLQILNAQEDNAGRYSCVAT 2649

Query: 427  NEAG 430
            NEAG
Sbjct: 2650 NEAG 2653



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 49/174 (28%), Positives = 83/174 (47%), Gaps = 13/174 (7%)

Query: 259  MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDA 318
            +++ EG    ++ + + +P P ++WY NGR +      +++   + LH    EV   SD 
Sbjct: 3069 VNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEV---SDT 3125

Query: 319  GAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE--GDSVKLECQISAIP 376
            G Y C A N AG       L+V        P  I  P+ + ++E   + V L C  + IP
Sbjct: 3126 GQYVCRAINVAGRDDKNFHLNVYV------PPSIEGPEREVIVETISNPVTLTCDATGIP 3179

Query: 377  PPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
            PP + W +N++ ++ N+D + + +  +G   L I      D+G YT  A N  G
Sbjct: 3180 PPTIAWLKNHKRIE-NSDSLEV-RILSGGSKLQIARSQHSDSGNYTCIASNMEG 3231



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 56/221 (25%), Positives = 92/221 (41%), Gaps = 10/221 (4%)

Query: 247  FYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLH 306
            + PP  +   +N+S+   +   +  +   +P P ++W  +G  +    L K  +S     
Sbjct: 2101 YVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPL----LKKPGLSISENR 2156

Query: 307  SLI-FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDS 365
            S++  E  +  D G Y C A N AG+      +++    +      + +     V+EG+ 
Sbjct: 2157 SVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQ---LTVIEGNL 2213

Query: 366  VKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSA 425
            + L C+ S IPPP L WK+    V   TD +   +  +G   L I    K DA  Y+  A
Sbjct: 2214 ISLLCESSGIPPPNLIWKKKGSPVL--TDSMGRVRILSGGRQLQISIAEKSDAALYSCVA 2271

Query: 426  VNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLAL 466
             N AG       L V  RP  T        +  T  K ++L
Sbjct: 2272 SNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISL 2312



 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 54/185 (29%), Positives = 80/185 (43%), Gaps = 29/185 (15%)

Query: 256  PENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGL------HSLI 309
            P  + +  G+   ++ +V G+P P V+W  +G           ++  KG+      H L 
Sbjct: 2299 PTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHP---------LIKAKGVEILDEGHILQ 2349

Query: 310  FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFI---YKPQSKKVLEGDSV 366
             + +  SD G Y CVA N AG       L V A      P  I     P++  V+E +SV
Sbjct: 2350 LKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHA-----PPSIIGNHRSPENISVVEKNSV 2404

Query: 367  KLECQISAIPPPKLFWKRNNEMVQF-NTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSA 425
             L C+ S IP P + W ++   V   N+ RI      +G   L +     +DAG YT   
Sbjct: 2405 SLTCEASGIPLPSITWFKDGWPVSLSNSVRIL-----SGGRMLRLMQTTMEDAGQYTCVV 2459

Query: 426  VNEAG 430
             N AG
Sbjct: 2460 RNAAG 2464



 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 53/204 (25%), Positives = 94/204 (46%), Gaps = 16/204 (7%)

Query: 231  STSRGDVNDQDAIQEKFYPPRFIQV--PENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGR 288
            +++R  V+++    + F PP        E +++ +G    M     G PAP ++W  +G+
Sbjct: 3415 ASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQ 3474

Query: 289  TVQSDDLHKMIVSEKGLHSLIFEVVRAS--DAGAYACVAKNRAGEATFTVQLDVLAKEHK 346
             +  D  H  + +    H ++ ++++A   D+G Y C+A N AGE +    L VL   H 
Sbjct: 3475 PLGLD-AHLTVST----HGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHI 3529

Query: 347  RAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV 406
                   + +   V+  + ++L C  S IP PK+ W ++   +   TD++   Q   G  
Sbjct: 3530 NGS---EEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLP-QTDQV---QTLGGGE 3582

Query: 407  TLLIKDVNKKDAGWYTVSAVNEAG 430
             L I     +D G YT  A + AG
Sbjct: 3583 VLRISTAQVEDTGRYTCLASSPAG 3606



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 50/175 (28%), Positives = 82/175 (46%), Gaps = 15/175 (8%)

Query: 274  SGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEAT 333
            +G+P P ++W  + + V +   +  I S   +  +   ++   DAG Y CVA N AGE  
Sbjct: 1851 NGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLE--DAGRYTCVATNAAGETQ 1908

Query: 334  FTVQLDVLAKEHKRAPMFIY---KPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQ 390
              +QL      H   P  +    K  ++ VL  + V+LEC+ +  P P + W ++N ++ 
Sbjct: 1909 QHIQL------HVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLS 1962

Query: 391  FNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPN 445
             +T    L   N G++ + I+     DAG Y   A+N AG T     L V   P+
Sbjct: 1963 GSTSMTFL---NRGQI-IDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS 2013



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 48/174 (27%), Positives = 75/174 (43%), Gaps = 17/174 (9%)

Query: 273  VSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAG-- 330
            ++G P P+  W  N   +    L    ++ +   SL  E V+  D G Y CVA N AG  
Sbjct: 914  LAGNPIPERRWIKNSAML----LQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTN 969

Query: 331  EATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQ 390
              T +V + VL       P   +  Q    +EG  V L C+ S  P P + W +  E++ 
Sbjct: 970  NKTTSVVVHVL-------PTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELIS 1022

Query: 391  FNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARP 444
             ++ + S   D     +L +     +++G Y  +A N AG      +L V  RP
Sbjct: 1023 TSSAKFSAGADG----SLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRP 1072



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 59/221 (26%), Positives = 94/221 (42%), Gaps = 33/221 (14%)

Query: 249  PPRFI--QVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLH 306
            PP  I    P  +S+   R   ++ +V G P PD+ W+ +G+ +   D +  ++ ++G  
Sbjct: 1451 PPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELL-DRG-Q 1508

Query: 307  SLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKK------- 359
             L  +  R +D G Y C   N AG            K+ K   + IY P S K       
Sbjct: 1509 VLHLKNARRNDKGRYQCTVSNAAG------------KQAKDIKLTIYIPPSIKGGNVTTD 1556

Query: 360  --VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKD 417
              VL    +KLEC+   +P P + W ++ + +  ++   +LY D  G+  L I      D
Sbjct: 1557 ISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQ--ALYIDK-GQY-LHIPRAQVSD 1612

Query: 418  AGWYTVSAVNEAGVTTCNTRLDVTARP----NQTLPAPKQL 454
            +  YT    N AG    +  +DV   P    N   P  KQ+
Sbjct: 1613 SATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQV 1653



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 52/193 (26%), Positives = 86/193 (44%), Gaps = 15/193 (7%)

Query: 255  VPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVR 314
            V  ++S+      +++ +  GLP P ++WY +G+ + S    + +  +KG + L     +
Sbjct: 1553 VTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSS--QALYIDKGQY-LHIPRAQ 1609

Query: 315  ASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMF---IYKPQSKKVLEGDSVKLECQ 371
             SD+  Y C   N AG A  +  +DV        PM    +  P +K+V+   S+ LEC+
Sbjct: 1610 VSDSATYTCHVANVAGTAEKSFHVDVYV-----PPMIEGNLATPLNKQVVIAHSLTLECK 1664

Query: 372  ISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGV 431
             +  P P L W ++   V+ N D I +     G   L I    + D G Y   A + AG 
Sbjct: 1665 AAGNPSPILTWLKDGVPVKAN-DNIRI---EAGGKKLEIMSAQEIDRGQYICVATSVAGE 1720

Query: 432  TTCNTRLDVTARP 444
                  +DV   P
Sbjct: 1721 KEIKYEVDVLVPP 1733



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 49/179 (27%), Positives = 78/179 (43%), Gaps = 14/179 (7%)

Query: 269  MDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRA--SDAGAYACVAK 326
            ++ + +G P P ++W  NG  +      +++ + +     +  +VRA  SD   Y CVA 
Sbjct: 3362 IECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQ-----VIRIVRAQVSDVAVYTCVAS 3416

Query: 327  NRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNN 386
            NRAG       L V A  +    M     +   VL+G S  + C     P P + W R+ 
Sbjct: 3417 NRAGVDNKHYNLQVFAPPNMDNSM---GTEEITVLKGSSTSMACITDGTPAPSMAWLRDG 3473

Query: 387  EMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPN 445
            + +  +     L     G V  L+K    +D+G YT  A NEAG  + +  L V   P+
Sbjct: 3474 QPLGLDAH---LTVSTHGMVLQLLK-AETEDSGKYTCIASNEAGEVSKHFILKVLEPPH 3528



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 54/224 (24%), Positives = 96/224 (42%), Gaps = 27/224 (12%)

Query: 220  LQVPTSQVRSRSTSRGDVNDQDAIQEK------FYPPRF---IQVPENMSIDEGRFCRMD 270
            L +P +QV   +T    V +     EK      + PP     +  P N  +       ++
Sbjct: 1603 LHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLE 1662

Query: 271  FKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAG 330
             K +G P+P ++W  +G  V+++D  ++    K L  +  + +   D G Y CVA + AG
Sbjct: 1663 CKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEI---DRGQYICVATSVAG 1719

Query: 331  EATFTVQLDVLA----KEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNN 386
            E     ++DVL     +       FI       V+  + ++L+C ++  PPP + W ++ 
Sbjct: 1720 EKEIKYEVDVLVPPAIEGGDETSYFI-------VMVNNLLELDCHVTGSPPPTIMWLKDG 1772

Query: 387  EMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAG 430
            +++    +R        GR  L+I      + G Y   A N AG
Sbjct: 1773 QLID---ERDGFKILLNGR-KLVIAQAQVSNTGLYRCMAANTAG 1812



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 52/190 (27%), Positives = 72/190 (37%), Gaps = 14/190 (7%)

Query: 256  PENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQS-DDLHKMIVSEKGLHSLIFEVVR 314
            P  +S+  G    +  +V  LP P ++W    + +      H  + S     S+     R
Sbjct: 1086 PVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPS----GSMKITETR 1141

Query: 315  ASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISA 374
             SD+G Y CVA N AG  T  V+L+V        P     P+  KV  G  V + C    
Sbjct: 1142 TSDSGMYLCVATNIAGNVTQAVKLNVHV-----PPKIQRGPKHLKVQVGQRVDIPCNAQG 1196

Query: 375  IPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTC 434
             P P + W +    +  + +      D     TL I      DAG YT  A N AG    
Sbjct: 1197 TPLPVITWSKGGSTMLVDGEHHVSNPDG----TLSIDQATPSDAGIYTCVATNIAGTDET 1252

Query: 435  NTRLDVTARP 444
               L V   P
Sbjct: 1253 EITLHVQEPP 1262



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 49/190 (25%), Positives = 84/190 (44%), Gaps = 13/190 (6%)

Query: 258  NMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRAS- 316
            N+S+   +   +  +V G P+P + WY +   V      + + + K     I ++ RA+ 
Sbjct: 1369 NVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGK-----ILKLFRATP 1423

Query: 317  -DAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAI 375
             DAG Y+C A N AG +     +DVL         F   P    V+    V LECQ+   
Sbjct: 1424 EDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNF---PNEVSVVLNRDVALECQVKGT 1480

Query: 376  PPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCN 435
            P P + W ++ + +      + L   + G+V L +K+  + D G Y  +  N AG    +
Sbjct: 1481 PFPDIHWFKDGKPLFLGDPNVELL--DRGQV-LHLKNARRNDKGRYQCTVSNAAGKQAKD 1537

Query: 436  TRLDVTARPN 445
             +L +   P+
Sbjct: 1538 IKLTIYIPPS 1547



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 43/197 (21%), Positives = 80/197 (40%), Gaps = 10/197 (5%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
            PP     P+++ I   +   ++    G+P P ++W  +G  +  +     I+    LH  
Sbjct: 3712 PPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLH-- 3769

Query: 309  IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
              +    +D G Y C+A N AG     + L V        P     P +  V+      L
Sbjct: 3770 -IQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVP-----PSIAPGPTNMTVIVNVQTTL 3823

Query: 369  ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
             C+ + IP P + W++N  ++  + ++ S    ++G + ++   V+  D   Y  +  N 
Sbjct: 3824 ACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVD--DTATYECTVTNG 3881

Query: 429  AGVTTCNTRLDVTARPN 445
            AG       L V   P+
Sbjct: 3882 AGDDKRTVDLTVQVPPS 3898



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 49/183 (26%), Positives = 78/183 (42%), Gaps = 15/183 (8%)

Query: 249  PPRFI-QVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHS 307
            PP F    P N     G    ++ +V G P P + W  N + V  +  H+  + + G  S
Sbjct: 4348 PPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQW--NRKGVDIEISHR--IRQLGNGS 4403

Query: 308  LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
            L        DAG Y CVA N AG    ++ L +     +  P+   +P    +  G  + 
Sbjct: 4404 LAIYGTVNEDAGDYTCVATNEAGVVERSMSLTL-----QSPPIITLEPVETVINAGGKII 4458

Query: 368  LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
            L CQ +  P P + W R    + ++ DR+++  +N    +L I D  K+D   +   A N
Sbjct: 4459 LNCQATGEPQPTITWSRQGHSISWD-DRVNVLSNN----SLYIADAQKEDTSEFECVARN 4513

Query: 428  EAG 430
              G
Sbjct: 4514 LMG 4516



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 51/197 (25%), Positives = 84/197 (42%), Gaps = 14/197 (7%)

Query: 249  PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNG-RTVQSDDLHKMIVSEKGLHS 307
            PP     P +  + +     +    SG+P P + W  NG R +   D ++++ S     +
Sbjct: 3896 PPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSG----A 3951

Query: 308  LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
            +     + + AG Y CVA+N AG A   V L V        P+   +P    V+  + + 
Sbjct: 3952 IEILATQLNHAGRYTCVARNAAGSAHRHVTLHV-----HEPPVIQPQPSELHVILNNPIL 4006

Query: 368  LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
            L C+ +  P P + W++  E +  NT   +     +G   L I    ++DAG Y   A N
Sbjct: 4007 LPCEATGTPSPFITWQK--EGINVNTSGRNHAVLPSG--GLQISRAVREDAGTYMCVAQN 4062

Query: 428  EAGVTTCNTRLDVTARP 444
             AG      +L+V   P
Sbjct: 4063 PAGTALGKIKLNVQVPP 4079



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 54/188 (28%), Positives = 84/188 (44%), Gaps = 14/188 (7%)

Query: 272  KVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRAS--DAGAYACVAKNRA 329
            + +  P P ++WY +G  + S D  K+++   G    + ++ RA   DAG Y CVA N A
Sbjct: 2800 ETNAAPPPTLTWYKDGHPLTSSD--KVLILPGGR---VLQIPRAKVEDAGRYTCVAVNEA 2854

Query: 330  GEATFTVQLDVLAKE-HKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEM 388
            GE +    + VL     K A   +  P+   VL   S  +EC  S  P P+  W+++ + 
Sbjct: 2855 GEDSLQYDVRVLVPPIIKGANSDL--PEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQP 2912

Query: 389  VQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTL 448
            +  +     L   + GR+ L I +    D G Y   A N AG       L+V   P+   
Sbjct: 2913 LLEDDHHKFL---SNGRI-LQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIG 2968

Query: 449  PAPKQLRV 456
            P  + L V
Sbjct: 2969 PKSENLTV 2976



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 44/178 (24%), Positives = 82/178 (46%), Gaps = 22/178 (12%)

Query: 277  PAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTV 336
            P   ++W+ +G  ++S+   +++   + L  L     +  +AG Y+CVA N AGE     
Sbjct: 2603 PPATITWFKDGTPLESNRNIRILPGGRTLQILN---AQEDNAGRYSCVATNEAGEMIKHY 2659

Query: 337  QLDVLAKEHKRAPMFIYK---------PQSKKVLEGDSVKLECQISAIPPPKLFWKRNNE 387
            ++ V        P  I K         P+  K+   +++ LEC+  AIP   L W ++ +
Sbjct: 2660 EVKVY------IPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQ 2713

Query: 388  MVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPN 445
             ++ + D +++  +     TL IK+    D G YT  A N AG    +  +++   P+
Sbjct: 2714 PLK-SDDHVNIAANGH---TLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPS 2767



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 48/174 (27%), Positives = 67/174 (38%), Gaps = 14/174 (8%)

Query: 281 VSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDV 340
           +S+  NG T+  D   K    E    +L    V  SD G Y C+A + AG        DV
Sbjct: 461 LSFVRNGVTLGVDQYLK----ESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDV 516

Query: 341 LAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQF-NTDRISLY 399
                   P  I  P +  V  G+   L C I +     L W+RN+  V+     RI   
Sbjct: 517 -----SEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIR-- 569

Query: 400 QDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQ 453
                 ++L +K V   DAG Y     +E G +  +  L V   P  T+    Q
Sbjct: 570 --TLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQ 621



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 26/92 (28%), Positives = 39/92 (42%), Gaps = 6/92 (6%)

Query: 367 KLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAV 426
           ++ C + ++ P  L + RN   V    D+   Y   +  V L I  V   D G+Y   AV
Sbjct: 448 QIPCSVDSLLPFTLSFVRNG--VTLGVDQ---YLKESASVNLDIAKVTLSDEGFYECIAV 502

Query: 427 NEAGVTTCNTRLDVTARPNQTLPAPKQLRVRP 458
           + AG     T  DV + P   +  P  + V P
Sbjct: 503 SSAGTGRAQTFFDV-SEPPPVIQVPNNVTVTP 533


>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2b [Homo sapiens]
          Length = 1378

 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 56/202 (27%), Positives = 97/202 (48%), Gaps = 21/202 (10%)

Query: 239 DQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD---- 294
           D   ++++ +PPR ++ P ++ + +G    ++ K  G P P + WY +G  V++D     
Sbjct: 20  DGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPR 79

Query: 295 LHKMIVSEKGLHSLIFEVVRAS--DAGAYACVAKNRAGEA---TFTVQLDVLAKEHKRAP 349
            H+M++    L  L     R S  D G+Y CVA+N  GEA     ++++ +L  + ++ P
Sbjct: 80  SHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNP 139

Query: 350 MFIYKPQSKKVLEGDSVKLECQ-ISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTL 408
             +       V  G+   LECQ     P P ++WK++   +    +RIS+         L
Sbjct: 140 TDVV------VAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGK-----L 188

Query: 409 LIKDVNKKDAGWYTVSAVNEAG 430
           +I +  K DAG YT    N  G
Sbjct: 189 MISNTRKSDAGMYTCVGTNMVG 210



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 64/245 (26%), Positives = 110/245 (44%), Gaps = 26/245 (10%)

Query: 235 GDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD 294
           G+ +   A    F  P F++ P N  + E        +V G P P V W  +       D
Sbjct: 210 GERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDA-----D 264

Query: 295 LHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYK 354
           L +     K  ++L  +   ++D G Y C+A+NR G+   +  L V A      P F+ +
Sbjct: 265 LPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP-----PQFVVR 319

Query: 355 PQSKKVLEGDSVKLECQISAIPPPKLFWKRN--------NEMVQFNTDRISLYQDNTGRV 406
           P+ + V +G +V   C+    P P +FW++         N+  Q N+ R S+    TG +
Sbjct: 320 PRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNS-RCSV--SPTGDL 376

Query: 407 TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLAL 466
           T  I ++ + DAG+Y   A+  AG      +L+VT   +     P  + ++   ++ LA+
Sbjct: 377 T--ITNIQRSDAGYYICQALTVAGSILAKAQLEVT---DVLTDRPPPIILQGPANQTLAV 431

Query: 467 NGKGL 471
           +G  L
Sbjct: 432 DGTAL 436



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 56/185 (30%), Positives = 79/185 (42%), Gaps = 24/185 (12%)

Query: 275 GLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEA-T 333
           G P P + W  +   V+ DD  + I    G   L+    R SDAG Y CV  N  GE  +
Sbjct: 159 GHPEPTIYWKKD--KVRIDDKEERISIRGG--KLMISNTRKSDAGMYTCVGTNMVGERDS 214

Query: 334 FTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNT 393
              +L V  +     P F+ +P ++ VLE ++V+  CQ+   P P + WK+++       
Sbjct: 215 DPAELTVFER-----PTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDD--ADLPR 267

Query: 394 DRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQ 453
            R  +  D     TL IK     D G Y   A N  G    +  L        T+ AP Q
Sbjct: 268 GRYDIKDD----YTLRIKKTMSTDEGTYMCIAENRVGKMEASATL--------TVRAPPQ 315

Query: 454 LRVRP 458
             VRP
Sbjct: 316 FVVRP 320



 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 54/200 (27%), Positives = 81/200 (40%), Gaps = 13/200 (6%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGR------TVQSDDLHKMIVSE 302
           PP+F+  P +  + +GR      +  G P P V W   G               +  VS 
Sbjct: 313 PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSP 372

Query: 303 KGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE 362
            G   L    ++ SDAG Y C A   AG      QL+V      R P  I +  + + L 
Sbjct: 373 TG--DLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLA 430

Query: 363 GDSVKL-ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWY 421
            D   L +C+ +  P P + W +          R ++ +  T    L IK++   D G Y
Sbjct: 431 VDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGT----LQIKNLRISDTGTY 486

Query: 422 TVSAVNEAGVTTCNTRLDVT 441
           T  A + +G T+ +  LDVT
Sbjct: 487 TCVATSSSGETSWSAVLDVT 506


>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2a [Homo sapiens]
          Length = 1394

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 55/198 (27%), Positives = 96/198 (48%), Gaps = 21/198 (10%)

Query: 243 IQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD----LHKM 298
           ++++ +PPR ++ P ++ + +G    ++ K  G P P + WY +G  V++D      H+M
Sbjct: 40  LRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRM 99

Query: 299 IVSEKGLHSLIFEVVRAS--DAGAYACVAKNRAGEA---TFTVQLDVLAKEHKRAPMFIY 353
           ++    L  L     R S  D G+Y CVA+N  GEA     ++++ +L  + ++ P  + 
Sbjct: 100 LLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVV 159

Query: 354 KPQSKKVLEGDSVKLECQ-ISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKD 412
                 V  G+   LECQ     P P ++WK++   +    +RIS+         L+I +
Sbjct: 160 ------VAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGK-----LMISN 208

Query: 413 VNKKDAGWYTVSAVNEAG 430
             K DAG YT    N  G
Sbjct: 209 TRKSDAGMYTCVGTNMVG 226



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 64/245 (26%), Positives = 110/245 (44%), Gaps = 26/245 (10%)

Query: 235 GDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD 294
           G+ +   A    F  P F++ P N  + E        +V G P P V W  +       D
Sbjct: 226 GERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDA-----D 280

Query: 295 LHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYK 354
           L +     K  ++L  +   ++D G Y C+A+NR G+   +  L V A      P F+ +
Sbjct: 281 LPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP-----PQFVVR 335

Query: 355 PQSKKVLEGDSVKLECQISAIPPPKLFWKRN--------NEMVQFNTDRISLYQDNTGRV 406
           P+ + V +G +V   C+    P P +FW++         N+  Q N+ R S+    TG +
Sbjct: 336 PRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNS-RCSV--SPTGDL 392

Query: 407 TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLAL 466
           T  I ++ + DAG+Y   A+  AG      +L+VT   +     P  + ++   ++ LA+
Sbjct: 393 T--ITNIQRSDAGYYICQALTVAGSILAKAQLEVT---DVLTDRPPPIILQGPANQTLAV 447

Query: 467 NGKGL 471
           +G  L
Sbjct: 448 DGTAL 452



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 56/185 (30%), Positives = 79/185 (42%), Gaps = 24/185 (12%)

Query: 275 GLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEA-T 333
           G P P + W  +   V+ DD  + I    G   L+    R SDAG Y CV  N  GE  +
Sbjct: 175 GHPEPTIYWKKD--KVRIDDKEERISIRGG--KLMISNTRKSDAGMYTCVGTNMVGERDS 230

Query: 334 FTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNT 393
              +L V  +     P F+ +P ++ VLE ++V+  CQ+   P P + WK+++       
Sbjct: 231 DPAELTVFER-----PTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDD--ADLPR 283

Query: 394 DRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQ 453
            R  +  D     TL IK     D G Y   A N  G    +  L        T+ AP Q
Sbjct: 284 GRYDIKDD----YTLRIKKTMSTDEGTYMCIAENRVGKMEASATL--------TVRAPPQ 331

Query: 454 LRVRP 458
             VRP
Sbjct: 332 FVVRP 336



 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 54/200 (27%), Positives = 81/200 (40%), Gaps = 13/200 (6%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGR------TVQSDDLHKMIVSE 302
           PP+F+  P +  + +GR      +  G P P V W   G               +  VS 
Sbjct: 329 PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSP 388

Query: 303 KGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLE 362
            G   L    ++ SDAG Y C A   AG      QL+V      R P  I +  + + L 
Sbjct: 389 TG--DLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLA 446

Query: 363 GDSVKL-ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWY 421
            D   L +C+ +  P P + W +          R ++ +  T    L IK++   D G Y
Sbjct: 447 VDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGT----LQIKNLRISDTGTY 502

Query: 422 TVSAVNEAGVTTCNTRLDVT 441
           T  A + +G T+ +  LDVT
Sbjct: 503 TCVATSSSGETSWSAVLDVT 522


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 56/206 (27%), Positives = 95/206 (46%), Gaps = 11/206 (5%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           PR    P+++ +  G       +  G P P++ W  N  ++  +D  ++ V + G  +L+
Sbjct: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDG--TLM 291

Query: 310 FEVVRASDAGAYACVAKNRAGEA-TFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
               R SD G Y C+A+N AGEA T +  L   +   K  P F+ +PQ  +VL G S  L
Sbjct: 292 IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAK--PSFVIQPQDTEVLIGTSTTL 349

Query: 369 ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
           EC  +  P P + W R+N +    +  ++          L ++++ ++D G +T  A N 
Sbjct: 350 ECMATGHPHPLITWTRDNGLELDGSRHVATSSG------LYLQNITQRDHGRFTCHANNS 403

Query: 429 AGVTTCNTRLDVTARPNQTLPAPKQL 454
            G       + V A P  T+    Q+
Sbjct: 404 HGTVQAAANIIVQAPPQFTVTPKDQV 429



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 55/194 (28%), Positives = 79/194 (40%), Gaps = 12/194 (6%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
           PP+F   P++  + E        +  G P P + W   G  +  +  H ++ S     +L
Sbjct: 418 PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSG----TL 473

Query: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
             +     D G Y C A +  G    +VQL V   + K   +F   PQ   V  G ++ +
Sbjct: 474 RIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV---KPKALAVFTQLPQDTSVEVGKNINI 530

Query: 369 ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            C     P P + W  N E VQ  T+    + D+ G  TL I D    D G Y   A N 
Sbjct: 531 SCHAQGEPQPIITW--NKEGVQI-TESGKFHVDDEG--TLTIYDAGFPDQGRYECVARNS 585

Query: 429 AGVTTCNTRLDVTA 442
            G+   N  L VTA
Sbjct: 586 FGLAVTNMFLTVTA 599



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 44/191 (23%), Positives = 73/191 (38%), Gaps = 15/191 (7%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P F+  P++  +  G    ++   +G P P ++W  +         H  + +  GL+   
Sbjct: 330 PSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRH--VATSSGLY--- 384

Query: 310 FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLE 369
            + +   D G + C A N  G       + V A      P F   P+ + VLE  +V+  
Sbjct: 385 LQNITQRDHGRFTCHANNSHGTVQAAANIIVQAP-----PQFTVTPKDQVVLEEHAVEWL 439

Query: 370 CQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEA 429
           C+    PPP + W +    +        L        TL I    + D G Y   AV+  
Sbjct: 440 CEADGNPPPVIVWTKTGGQLPVEGQHTVLSSG-----TLRIDRAAQHDQGQYECQAVSSL 494

Query: 430 GVTTCNTRLDV 440
           GV   + +L V
Sbjct: 495 GVKKVSVQLTV 505



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 25/85 (29%), Positives = 44/85 (51%), Gaps = 5/85 (5%)

Query: 347 RAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTD-RISLYQDNTGR 405
           ++P   ++PQ  +V  G++V   C+    P P++ W  NN  +    D R++++ D    
Sbjct: 232 QSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDG--- 288

Query: 406 VTLLIKDVNKKDAGWYTVSAVNEAG 430
            TL+I++  + D G Y   A N AG
Sbjct: 289 -TLMIRNTRESDQGVYQCMARNSAG 312



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 29/97 (29%), Positives = 47/97 (48%), Gaps = 4/97 (4%)

Query: 252 FIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFE 311
           F Q+P++ S++ G+   +     G P P ++W  N   VQ  +  K  V ++G  +L   
Sbjct: 513 FTQLPQDTSVEVGKNINISCHAQGEPQPIITW--NKEGVQITESGKFHVDDEG--TLTIY 568

Query: 312 VVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRA 348
                D G Y CVA+N  G A   + L V A + ++A
Sbjct: 569 DAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQA 605


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 57/203 (28%), Positives = 92/203 (45%), Gaps = 15/203 (7%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           PR    P++  +  G       +  G P P++ W  N   +      ++ + + G  +L+
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG--TLM 303

Query: 310 FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLE 369
            +  + +D G Y C+AKN AGE   T ++ +        P F+ +PQ+ +VL G+SV LE
Sbjct: 304 IQNTQETDQGIYQCMAKNVAGEVK-TQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLE 362

Query: 370 CQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVT----LLIKDVNKKDAGWYTVSA 425
           C  +  PPP++ W R         DR  L  D    +T    L I++V + D+G Y  SA
Sbjct: 363 CSATGHPPPRISWTRG--------DRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSA 414

Query: 426 VNEAGVTTCNTRLDVTARPNQTL 448
            N          + V A P  T+
Sbjct: 415 TNNIDSVHATAFIIVQALPQFTV 437



 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 62/212 (29%), Positives = 84/212 (39%), Gaps = 16/212 (7%)

Query: 235 GDVNDQDAIQEKFYPPR---FIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQ 291
           G+V  Q+     F  P    F+  P+N  +  G    ++   +G P P +SW    RT  
Sbjct: 324 GEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPL 383

Query: 292 SDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMF 351
             D    I    GL+    + V   D+G YAC A N       T  + V A      P F
Sbjct: 384 PVDPRVNITPSGGLY---IQNVVQGDSGEYACSATNNIDSVHATAFIIVQA-----LPQF 435

Query: 352 IYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIK 411
              PQ + V+EG +V  +C+    PPP + W +     Q + DR  L   +    TL I 
Sbjct: 436 TVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGS--QLSVDRRHLVLSSG---TLRIS 490

Query: 412 DVNKKDAGWYTVSAVNEAGVTTCNTRLDVTAR 443
            V   D G Y   AVN  G       L V  R
Sbjct: 491 GVALHDQGQYECQAVNIIGSQKVVAHLTVQPR 522



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 51/191 (26%), Positives = 76/191 (39%), Gaps = 12/191 (6%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P+F   P++  + EG+      +  G P P ++W   G  +  D  H ++ S     +L 
Sbjct: 433 PQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSG----TLR 488

Query: 310 FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLE 369
              V   D G Y C A N  G       L V   + +  P+F   P    V  G +V+L 
Sbjct: 489 ISGVALHDQGQYECQAVNIIGSQKVVAHLTV---QPRVTPVFASIPSDTTVEVGANVQLP 545

Query: 370 CQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEA 429
           C     P P + W ++   V   T+    +    G +T  I DV   DAG Y   A N  
Sbjct: 546 CSSQGEPEPAITWNKDGVQV---TESGKFHISPEGFLT--INDVGPADAGRYECVARNTI 600

Query: 430 GVTTCNTRLDV 440
           G  + +  L V
Sbjct: 601 GSASVSMVLSV 611


>gi|222352127 sidekick 2 [Homo sapiens]
          Length = 2172

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 57/212 (26%), Positives = 96/212 (45%), Gaps = 8/212 (3%)

Query: 249 PPRFIQVPE-NMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHS 307
           PP+F++ PE +++ +  +   +  +  G+P P ++WY +   V+ + L +      G   
Sbjct: 307 PPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDG--G 364

Query: 308 LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
           L    +   D G + C A+N AGE   +  L V +     AP     P    V++G SV 
Sbjct: 365 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSI----APNITRGPLDSTVIDGMSVV 420

Query: 368 LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
           L C+ S  P P + W++   ++   + ++  +       +LLI   +  DAG YT  A N
Sbjct: 421 LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESG-SLLISPTHISDAGTYTCLATN 479

Query: 428 EAGVTTCNTRLDVTARPNQTLPAPKQLRVRPT 459
             GV   +  L V AR   T P   Q  ++ T
Sbjct: 480 SRGVDEASADLVVWARTRITKPPQDQSVIKGT 511



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 49/214 (22%), Positives = 85/214 (39%), Gaps = 12/214 (5%)

Query: 235 GDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD 294
           G+V     +      P   + P + ++ +G    +  + SG P P ++W    R + S  
Sbjct: 387 GEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGS 446

Query: 295 LHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYK 354
           +     +     SL+      SDAG Y C+A N  G    +  L V A+     P     
Sbjct: 447 VQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKP----- 501

Query: 355 PQSKKVLEGDSVKLECQISAIP--PPKLFWKRNNEMVQFNT-DRISLYQDNTGRVTLLIK 411
           PQ + V++G    + C ++  P    +  W+++   +   +  RI L  D  G  +L I 
Sbjct: 502 PQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRL--DRNG--SLHIS 557

Query: 412 DVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPN 445
                D G YT   ++  G  + +  L V   P+
Sbjct: 558 QTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPH 591



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 45/164 (27%), Positives = 70/164 (42%), Gaps = 21/164 (12%)

Query: 272 KVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGE 331
           +++  P P V+W+ +GR +       + +     ++L+     A DAG Y   A N    
Sbjct: 136 RIASFPQPQVTWFRDGRKIPPSSRIAITLE----NTLVILSTVAPDAGRYYVQAVNDKNG 191

Query: 332 ATFTVQLDVLAKEH------KRAPMFIYKPQSKKVLEGDS-VKLECQISAIPPPKL--FW 382
              T Q   L  E+        AP  I  P++  V+ G S V LEC  +A P  KL   W
Sbjct: 192 DNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIW 251

Query: 383 KRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAV 426
           K++  ++           D+  R+T  I +    DAG+Y   AV
Sbjct: 252 KKDGVLLSGG------ISDHNRRLT--IPNPTGSDAGYYECEAV 287



 Score = 37.4 bits (85), Expect = 0.032
 Identities = 32/112 (28%), Positives = 54/112 (48%), Gaps = 10/112 (8%)

Query: 318 AGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLEC-QISAIP 376
           AG Y C+ +NR G A    Q +V   +      F    + + V  G++  +   +I++ P
Sbjct: 86  AGFYRCIVRNRMG-ALLQRQTEV---QVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFP 141

Query: 377 PPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
            P++ W R+   +   + RI++  +NT    L+I      DAG Y V AVN+
Sbjct: 142 QPQVTWFRDGRKIP-PSSRIAITLENT----LVILSTVAPDAGRYYVQAVND 188


>gi|169217528 PREDICTED: similar to sidekick homolog 2 (chicken)
           [Homo sapiens]
          Length = 399

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 57/212 (26%), Positives = 96/212 (45%), Gaps = 8/212 (3%)

Query: 249 PPRFIQVPE-NMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHS 307
           PP+F++ PE +++ +  +   +  +  G+P P ++WY +   V+ + L +      G   
Sbjct: 119 PPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDG--G 176

Query: 308 LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
           L    +   D G + C A+N AGE   +  L V +     AP     P    V++G SV 
Sbjct: 177 LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSI----APNITRGPLDSTVIDGMSVV 232

Query: 368 LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
           L C+ S  P P + W++   ++   + ++  +       +LLI   +  DAG YT  A N
Sbjct: 233 LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESG-SLLISPTHISDAGTYTCLATN 291

Query: 428 EAGVTTCNTRLDVTARPNQTLPAPKQLRVRPT 459
             GV   +  L V AR   T P   Q  ++ T
Sbjct: 292 SRGVDEASADLVVWARTRITKPPQDQSVIKGT 323



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 33/142 (23%), Positives = 57/142 (40%), Gaps = 5/142 (3%)

Query: 235 GDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD 294
           G+V     +      P   + P + ++ +G    +  + SG P P ++W    R + S  
Sbjct: 199 GEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGS 258

Query: 295 LHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYK 354
           +     +     SL+      SDAG Y C+A N  G    +  L V A+     P     
Sbjct: 259 VQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKP----- 313

Query: 355 PQSKKVLEGDSVKLECQISAIP 376
           PQ + V++G    + C ++  P
Sbjct: 314 PQDQSVIKGTQASMVCGVTHDP 335


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 2 [Homo sapiens]
          Length = 1119

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 57/202 (28%), Positives = 91/202 (45%), Gaps = 13/202 (6%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRT--VQSDDLHKMIVSEKGLHS 307
           P F + P +++I  G   R++    G PAP ++W  +G T    + +    ++ E  +  
Sbjct: 603 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFF 662

Query: 308 LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
           ++   V+  D G Y+C A+N AG  +    L VL       P F+     + V +G++  
Sbjct: 663 IV--DVKIEDIGVYSCTAQNSAGSISANATLTVL-----ETPSFLRPLLDRTVTKGETAV 715

Query: 368 LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
           L+C     PPPKL W +++  +   T+R   +    G   L+I D +  DAG YT    N
Sbjct: 716 LQCIAGGSPPPKLNWTKDDSPLVV-TER---HFFAAGNQLLIIVDSDVSDAGKYTCEMSN 771

Query: 428 EAGVTTCNTRLDVTARPNQTLP 449
             G    N RL V   P    P
Sbjct: 772 TLGTERGNVRLSVIPTPTCDSP 793


>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 1 [Homo sapiens]
          Length = 1059

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 57/202 (28%), Positives = 91/202 (45%), Gaps = 13/202 (6%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRT--VQSDDLHKMIVSEKGLHS 307
           P F + P +++I  G   R++    G PAP ++W  +G T    + +    ++ E  +  
Sbjct: 543 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFF 602

Query: 308 LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVK 367
           ++   V+  D G Y+C A+N AG  +    L VL       P F+     + V +G++  
Sbjct: 603 IV--DVKIEDIGVYSCTAQNSAGSISANATLTVL-----ETPSFLRPLLDRTVTKGETAV 655

Query: 368 LECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVN 427
           L+C     PPPKL W +++  +   T+R   +    G   L+I D +  DAG YT    N
Sbjct: 656 LQCIAGGSPPPKLNWTKDDSPLVV-TER---HFFAAGNQLLIIVDSDVSDAGKYTCEMSN 711

Query: 428 EAGVTTCNTRLDVTARPNQTLP 449
             G    N RL V   P    P
Sbjct: 712 TLGTERGNVRLSVIPTPTCDSP 733


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 57/199 (28%), Positives = 92/199 (46%), Gaps = 21/199 (10%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P F++ P N+++          +  G P P V W  +       +L K     +  H+L 
Sbjct: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD-----DGELPKSRYEIRDDHTLK 277

Query: 310 FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLE 369
              V A D G+Y CVA+N  G+A  +  L V     +  P F+ KP+ + V  G +V  +
Sbjct: 278 IRKVTAGDMGSYTCVAENMVGKAEASATLTV-----QEPPHFVVKPRDQVVALGRTVTFQ 332

Query: 370 CQISAIPPPKLFWKR---NNEMVQF----NTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
           C+ +  P P +FW+R    N +  +    ++ R S+ Q  TG +T  I +V + D G+Y 
Sbjct: 333 CEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ--TGDLT--ITNVQRSDVGYYI 388

Query: 423 VSAVNEAGVTTCNTRLDVT 441
              +N AG       L+VT
Sbjct: 389 CQTLNVAGSIITKAYLEVT 407



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 22/214 (10%)

Query: 243 IQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD----LHKM 298
           ++++ +PPR ++ P ++ + +G    ++ K  G P P + WY  G  V++D      H+M
Sbjct: 22  LRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM 81

Query: 299 IVSEKGLHSLIFEVVRAS--DAGAYACVAKNRAGEA---TFTVQLDVLAKEHKRAPMFIY 353
           ++    L  L     R S  D G Y CVA+N  GEA     ++++ +L  +      F  
Sbjct: 82  LLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD------FRQ 135

Query: 354 KPQSKKVLEGDSVKLECQ-ISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKD 412
            P    V  G+   +ECQ     P P + WK++   +    +RI++         L+I  
Sbjct: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-----LMITY 190

Query: 413 VNKKDAGWYTVSAVNEAGVTTCN-TRLDVTARPN 445
             K DAG Y     N  G        L V  RP+
Sbjct: 191 TRKSDAGKYVCVGTNMVGERESEVAELTVLERPS 224



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 57/196 (29%), Positives = 86/196 (43%), Gaps = 17/196 (8%)

Query: 252 FIQVPENMSIDEGRFCRMDFKVS-GLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
           F Q P ++ +  G    M+ +   G P P +SW  +G  +  DD  + I    G   L+ 
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL--DDKDERITIRGG--KLMI 188

Query: 311 EVVRASDAGAYACVAKNRAGEATFTV-QLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLE 369
              R SDAG Y CV  N  GE    V +L VL +     P F+ +P +  V   DS + +
Sbjct: 189 TYTRKSDAGKYVCVGTNMVGERESEVAELTVLER-----PSFVKRPSNLAVTVDDSAEFK 243

Query: 370 CQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEA 429
           C+    P P + W++++   +    R  +  D+T    L I+ V   D G YT  A N  
Sbjct: 244 CEARGDPVPTVRWRKDDG--ELPKSRYEIRDDHT----LKIRKVTAGDMGSYTCVAENMV 297

Query: 430 GVTTCNTRLDVTARPN 445
           G    +  L V   P+
Sbjct: 298 GKAEASATLTVQEPPH 313



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 51/201 (25%), Positives = 79/201 (39%), Gaps = 17/201 (8%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNG--------RTVQSDDLHKMIV 300
           PP F+  P +  +  GR      + +G P P + W   G        +  QS    +  V
Sbjct: 311 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS--RFSV 368

Query: 301 SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYK-PQSKK 359
           S+ G   L    V+ SD G Y C   N AG       L+V      R P  I + P ++ 
Sbjct: 369 SQTG--DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 426

Query: 360 VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
           V    +  L C  +  P P + W+++  +V     RI   ++      L I+     D G
Sbjct: 427 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG----VLQIRYAKLGDTG 482

Query: 420 WYTVSAVNEAGVTTCNTRLDV 440
            YT  A   +G  T +  ++V
Sbjct: 483 RYTCIASTPSGEATWSAYIEV 503


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 57/199 (28%), Positives = 92/199 (46%), Gaps = 21/199 (10%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P F++ P N+++          +  G P P V W  +       +L K     +  H+L 
Sbjct: 262 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD-----DGELPKSRYEIRDDHTLK 316

Query: 310 FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLE 369
              V A D G+Y CVA+N  G+A  +  L V     +  P F+ KP+ + V  G +V  +
Sbjct: 317 IRKVTAGDMGSYTCVAENMVGKAEASATLTV-----QEPPHFVVKPRDQVVALGRTVTFQ 371

Query: 370 CQISAIPPPKLFWKR---NNEMVQF----NTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
           C+ +  P P +FW+R    N +  +    ++ R S+ Q  TG +T  I +V + D G+Y 
Sbjct: 372 CEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ--TGDLT--ITNVQRSDVGYYI 427

Query: 423 VSAVNEAGVTTCNTRLDVT 441
              +N AG       L+VT
Sbjct: 428 CQTLNVAGSIITKAYLEVT 446



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 22/214 (10%)

Query: 243 IQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD----LHKM 298
           ++++ +PPR ++ P ++ + +G    ++ K  G P P + WY  G  V++D      H+M
Sbjct: 61  LRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM 120

Query: 299 IVSEKGLHSLIFEVVRAS--DAGAYACVAKNRAGEA---TFTVQLDVLAKEHKRAPMFIY 353
           ++    L  L     R S  D G Y CVA+N  GEA     ++++ +L  +      F  
Sbjct: 121 LLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD------FRQ 174

Query: 354 KPQSKKVLEGDSVKLECQ-ISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKD 412
            P    V  G+   +ECQ     P P + WK++   +    +RI++         L+I  
Sbjct: 175 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-----LMITY 229

Query: 413 VNKKDAGWYTVSAVNEAGVTTCN-TRLDVTARPN 445
             K DAG Y     N  G        L V  RP+
Sbjct: 230 TRKSDAGKYVCVGTNMVGERESEVAELTVLERPS 263



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 57/196 (29%), Positives = 86/196 (43%), Gaps = 17/196 (8%)

Query: 252 FIQVPENMSIDEGRFCRMDFKVS-GLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIF 310
           F Q P ++ +  G    M+ +   G P P +SW  +G  +  DD  + I    G   L+ 
Sbjct: 172 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL--DDKDERITIRGG--KLMI 227

Query: 311 EVVRASDAGAYACVAKNRAGEATFTV-QLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLE 369
              R SDAG Y CV  N  GE    V +L VL +     P F+ +P +  V   DS + +
Sbjct: 228 TYTRKSDAGKYVCVGTNMVGERESEVAELTVLER-----PSFVKRPSNLAVTVDDSAEFK 282

Query: 370 CQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEA 429
           C+    P P + W++++   +    R  +  D+T    L I+ V   D G YT  A N  
Sbjct: 283 CEARGDPVPTVRWRKDDG--ELPKSRYEIRDDHT----LKIRKVTAGDMGSYTCVAENMV 336

Query: 430 GVTTCNTRLDVTARPN 445
           G    +  L V   P+
Sbjct: 337 GKAEASATLTVQEPPH 352



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 51/201 (25%), Positives = 79/201 (39%), Gaps = 17/201 (8%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNG--------RTVQSDDLHKMIV 300
           PP F+  P +  +  GR      + +G P P + W   G        +  QS    +  V
Sbjct: 350 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS--RFSV 407

Query: 301 SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYK-PQSKK 359
           S+ G   L    V+ SD G Y C   N AG       L+V      R P  I + P ++ 
Sbjct: 408 SQTG--DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 465

Query: 360 VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
           V    +  L C  +  P P + W+++  +V     RI   ++      L I+     D G
Sbjct: 466 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG----VLQIRYAKLGDTG 521

Query: 420 WYTVSAVNEAGVTTCNTRLDV 440
            YT  A   +G  T +  ++V
Sbjct: 522 RYTCIASTPSGEATWSAYIEV 542


>gi|224994173 roundabout 1 isoform d [Homo sapiens]
          Length = 1551

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 57/199 (28%), Positives = 92/199 (46%), Gaps = 18/199 (9%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P F++ P N+++          +  G P P V W  +       +L K     +  H+L 
Sbjct: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD-----DGELPKSRYEIRDDHTLK 277

Query: 310 FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLE 369
              V A D G+Y CVA+N  G+A  +  L V  +     P F+ KP+ + V  G +V  +
Sbjct: 278 IRKVTAGDMGSYTCVAENMVGKAEASATLTV--QVGSEPPHFVVKPRDQVVALGRTVTFQ 335

Query: 370 CQISAIPPPKLFWKR---NNEMVQF----NTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
           C+ +  P P +FW+R    N +  +    ++ R S+ Q  TG +T  I +V + D G+Y 
Sbjct: 336 CEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ--TGDLT--ITNVQRSDVGYYI 391

Query: 423 VSAVNEAGVTTCNTRLDVT 441
              +N AG       L+VT
Sbjct: 392 CQTLNVAGSIITKAYLEVT 410



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 22/214 (10%)

Query: 243 IQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD----LHKM 298
           ++++ +PPR ++ P ++ + +G    ++ K  G P P + WY  G  V++D      H+M
Sbjct: 22  LRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM 81

Query: 299 IVSEKGLHSLIFEVVRAS--DAGAYACVAKNRAGEA---TFTVQLDVLAKEHKRAPMFIY 353
           ++    L  L     R S  D G Y CVA+N  GEA     ++++ +L  +      F  
Sbjct: 82  LLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD------FRQ 135

Query: 354 KPQSKKVLEGDSVKLECQ-ISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKD 412
            P    V  G+   +ECQ     P P + WK++   +    +RI++         L+I  
Sbjct: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-----LMITY 190

Query: 413 VNKKDAGWYTVSAVNEAGVTTCN-TRLDVTARPN 445
             K DAG Y     N  G        L V  RP+
Sbjct: 191 TRKSDAGKYVCVGTNMVGERESEVAELTVLERPS 224



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 51/201 (25%), Positives = 79/201 (39%), Gaps = 17/201 (8%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNG--------RTVQSDDLHKMIV 300
           PP F+  P +  +  GR      + +G P P + W   G        +  QS    +  V
Sbjct: 314 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS--RFSV 371

Query: 301 SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYK-PQSKK 359
           S+ G   L    V+ SD G Y C   N AG       L+V      R P  I + P ++ 
Sbjct: 372 SQTG--DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429

Query: 360 VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
           V    +  L C  +  P P + W+++  +V     RI   ++      L I+     D G
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG----VLQIRYAKLGDTG 485

Query: 420 WYTVSAVNEAGVTTCNTRLDV 440
            YT  A   +G  T +  ++V
Sbjct: 486 RYTCIASTPSGEATWSAYIEV 506


>gi|224994171 roundabout 1 isoform c [Homo sapiens]
          Length = 1606

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 57/199 (28%), Positives = 92/199 (46%), Gaps = 18/199 (9%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P F++ P N+++          +  G P P V W  +       +L K     +  H+L 
Sbjct: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD-----DGELPKSRYEIRDDHTLK 277

Query: 310 FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLE 369
              V A D G+Y CVA+N  G+A  +  L V  +     P F+ KP+ + V  G +V  +
Sbjct: 278 IRKVTAGDMGSYTCVAENMVGKAEASATLTV--QVGSEPPHFVVKPRDQVVALGRTVTFQ 335

Query: 370 CQISAIPPPKLFWKR---NNEMVQF----NTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
           C+ +  P P +FW+R    N +  +    ++ R S+ Q  TG +T  I +V + D G+Y 
Sbjct: 336 CEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ--TGDLT--ITNVQRSDVGYYI 391

Query: 423 VSAVNEAGVTTCNTRLDVT 441
              +N AG       L+VT
Sbjct: 392 CQTLNVAGSIITKAYLEVT 410



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 22/214 (10%)

Query: 243 IQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD----LHKM 298
           ++++ +PPR ++ P ++ + +G    ++ K  G P P + WY  G  V++D      H+M
Sbjct: 22  LRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM 81

Query: 299 IVSEKGLHSLIFEVVRAS--DAGAYACVAKNRAGEA---TFTVQLDVLAKEHKRAPMFIY 353
           ++    L  L     R S  D G Y CVA+N  GEA     ++++ +L  +      F  
Sbjct: 82  LLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD------FRQ 135

Query: 354 KPQSKKVLEGDSVKLECQ-ISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKD 412
            P    V  G+   +ECQ     P P + WK++   +    +RI++         L+I  
Sbjct: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-----LMITY 190

Query: 413 VNKKDAGWYTVSAVNEAGVTTCN-TRLDVTARPN 445
             K DAG Y     N  G        L V  RP+
Sbjct: 191 TRKSDAGKYVCVGTNMVGERESEVAELTVLERPS 224



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 51/201 (25%), Positives = 79/201 (39%), Gaps = 17/201 (8%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNG--------RTVQSDDLHKMIV 300
           PP F+  P +  +  GR      + +G P P + W   G        +  QS    +  V
Sbjct: 314 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS--RFSV 371

Query: 301 SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYK-PQSKK 359
           S+ G   L    V+ SD G Y C   N AG       L+V      R P  I + P ++ 
Sbjct: 372 SQTG--DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429

Query: 360 VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
           V    +  L C  +  P P + W+++  +V     RI   ++      L I+     D G
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG----VLQIRYAKLGDTG 485

Query: 420 WYTVSAVNEAGVTTCNTRLDV 440
            YT  A   +G  T +  ++V
Sbjct: 486 RYTCIASTPSGEATWSAYIEV 506


>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
           sapiens]
          Length = 1562

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 57/199 (28%), Positives = 92/199 (46%), Gaps = 18/199 (9%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P F++ P N+++          +  G P P V W  +       +L K     +  H+L 
Sbjct: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD-----DGELPKSRYEIRDDHTLK 277

Query: 310 FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLE 369
              V A D G+Y CVA+N  G+A  +  L V  +     P F+ KP+ + V  G +V  +
Sbjct: 278 IRKVTAGDMGSYTCVAENMVGKAEASATLTV--QVGSEPPHFVVKPRDQVVALGRTVTFQ 335

Query: 370 CQISAIPPPKLFWKR---NNEMVQF----NTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
           C+ +  P P +FW+R    N +  +    ++ R S+ Q  TG +T  I +V + D G+Y 
Sbjct: 336 CEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ--TGDLT--ITNVQRSDVGYYI 391

Query: 423 VSAVNEAGVTTCNTRLDVT 441
              +N AG       L+VT
Sbjct: 392 CQTLNVAGSIITKAYLEVT 410



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 22/214 (10%)

Query: 243 IQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD----LHKM 298
           ++++ +PPR ++ P ++ + +G    ++ K  G P P + WY  G  V++D      H+M
Sbjct: 22  LRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM 81

Query: 299 IVSEKGLHSLIFEVVRAS--DAGAYACVAKNRAGEA---TFTVQLDVLAKEHKRAPMFIY 353
           ++    L  L     R S  D G Y CVA+N  GEA     ++++ +L  +      F  
Sbjct: 82  LLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD------FRQ 135

Query: 354 KPQSKKVLEGDSVKLECQ-ISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKD 412
            P    V  G+   +ECQ     P P + WK++   +    +RI++         L+I  
Sbjct: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-----LMITY 190

Query: 413 VNKKDAGWYTVSAVNEAGVTTCN-TRLDVTARPN 445
             K DAG Y     N  G        L V  RP+
Sbjct: 191 TRKSDAGKYVCVGTNMVGERESEVAELTVLERPS 224



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 51/201 (25%), Positives = 79/201 (39%), Gaps = 17/201 (8%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNG--------RTVQSDDLHKMIV 300
           PP F+  P +  +  GR      + +G P P + W   G        +  QS    +  V
Sbjct: 314 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS--RFSV 371

Query: 301 SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYK-PQSKK 359
           S+ G   L    V+ SD G Y C   N AG       L+V      R P  I + P ++ 
Sbjct: 372 SQTG--DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429

Query: 360 VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
           V    +  L C  +  P P + W+++  +V     RI   ++      L I+     D G
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG----VLQIRYAKLGDTG 485

Query: 420 WYTVSAVNEAGVTTCNTRLDV 440
            YT  A   +G  T +  ++V
Sbjct: 486 RYTCIASTPSGEATWSAYIEV 506


>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
           sapiens]
          Length = 1615

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 57/199 (28%), Positives = 92/199 (46%), Gaps = 18/199 (9%)

Query: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLI 309
           P F++ P N+++          +  G P P V W  +       +L K     +  H+L 
Sbjct: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD-----DGELPKSRYEIRDDHTLK 277

Query: 310 FEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLE 369
              V A D G+Y CVA+N  G+A  +  L V  +     P F+ KP+ + V  G +V  +
Sbjct: 278 IRKVTAGDMGSYTCVAENMVGKAEASATLTV--QVGSEPPHFVVKPRDQVVALGRTVTFQ 335

Query: 370 CQISAIPPPKLFWKR---NNEMVQF----NTDRISLYQDNTGRVTLLIKDVNKKDAGWYT 422
           C+ +  P P +FW+R    N +  +    ++ R S+ Q  TG +T  I +V + D G+Y 
Sbjct: 336 CEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ--TGDLT--ITNVQRSDVGYYI 391

Query: 423 VSAVNEAGVTTCNTRLDVT 441
              +N AG       L+VT
Sbjct: 392 CQTLNVAGSIITKAYLEVT 410



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 22/214 (10%)

Query: 243 IQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD----LHKM 298
           ++++ +PPR ++ P ++ + +G    ++ K  G P P + WY  G  V++D      H+M
Sbjct: 22  LRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM 81

Query: 299 IVSEKGLHSLIFEVVRAS--DAGAYACVAKNRAGEA---TFTVQLDVLAKEHKRAPMFIY 353
           ++    L  L     R S  D G Y CVA+N  GEA     ++++ +L  +      F  
Sbjct: 82  LLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD------FRQ 135

Query: 354 KPQSKKVLEGDSVKLECQ-ISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKD 412
            P    V  G+   +ECQ     P P + WK++   +    +RI++         L+I  
Sbjct: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-----LMITY 190

Query: 413 VNKKDAGWYTVSAVNEAGVTTCN-TRLDVTARPN 445
             K DAG Y     N  G        L V  RP+
Sbjct: 191 TRKSDAGKYVCVGTNMVGERESEVAELTVLERPS 224



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 51/201 (25%), Positives = 79/201 (39%), Gaps = 17/201 (8%)

Query: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNG--------RTVQSDDLHKMIV 300
           PP F+  P +  +  GR      + +G P P + W   G        +  QS    +  V
Sbjct: 314 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS--RFSV 371

Query: 301 SEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYK-PQSKK 359
           S+ G   L    V+ SD G Y C   N AG       L+V      R P  I + P ++ 
Sbjct: 372 SQTG--DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429

Query: 360 VLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAG 419
           V    +  L C  +  P P + W+++  +V     RI   ++      L I+     D G
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG----VLQIRYAKLGDTG 485

Query: 420 WYTVSAVNEAGVTTCNTRLDV 440
            YT  A   +G  T +  ++V
Sbjct: 486 RYTCIASTPSGEATWSAYIEV 506


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.127    0.367 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,927,512
Number of Sequences: 37866
Number of extensions: 914378
Number of successful extensions: 6554
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 220
Number of HSP's successfully gapped in prelim test: 225
Number of HSP's that attempted gapping in prelim test: 2856
Number of HSP's gapped (non-prelim): 2121
length of query: 498
length of database: 18,247,518
effective HSP length: 106
effective length of query: 392
effective length of database: 14,233,722
effective search space: 5579619024
effective search space used: 5579619024
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.