Search of human proteins with 57863304

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo
sapiens]
         (1353 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens]     2727   0.0  
gi|126032348 hect domain and RLD 2 [Homo sapiens]                      92   3e-18
gi|7657152 hect domain and RLD 3 [Homo sapiens]                        90   2e-17
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]    85   4e-16
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]             84   1e-15
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]             84   1e-15
gi|110825982 hect domain and RLD 5 [Homo sapiens]                      82   5e-15
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]     79   2e-14
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]      79   2e-14
gi|4557445 regulator of chromosome condensation and BTB domain c...    74   7e-13
gi|8922528 kelch-like 11 [Homo sapiens]                                74   1e-12
gi|6912330 deafness locus associated putative guanine nucleotide...    73   2e-12
gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo s...    72   5e-12
gi|56117834 speckle-type POZ protein [Homo sapiens]                    71   6e-12
gi|56117832 speckle-type POZ protein [Homo sapiens]                    71   6e-12
gi|56117830 speckle-type POZ protein [Homo sapiens]                    71   6e-12
gi|56117828 speckle-type POZ protein [Homo sapiens]                    71   6e-12
gi|4507183 speckle-type POZ protein [Homo sapiens]                     71   6e-12
gi|56117836 speckle-type POZ protein [Homo sapiens]                    71   6e-12
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ...    71   8e-12
gi|30039692 NIMA-related kinase 8 [Homo sapiens]                       71   8e-12
gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s...    68   7e-11
gi|148664209 kelch-like 10 [Homo sapiens]                              67   9e-11
gi|126116565 MYC binding protein 2 [Homo sapiens]                      67   1e-10
gi|222136641 NIMA-related kinase 9 [Homo sapiens]                      67   2e-10
gi|45333883 kelch repeat and BTB (POZ) domain-containing 6 [Homo...    67   2e-10
gi|109150407 kelch-like 6 [Homo sapiens]                               66   2e-10
gi|48717263 speckle-type POZ protein-like [Homo sapiens]               66   2e-10
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo...    64   1e-09
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    64   1e-09

>gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens]
          Length = 1353

 Score = 2727 bits (7070), Expect = 0.0
 Identities = 1353/1353 (100%), Positives = 1353/1353 (100%)

Query: 1    MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS 60
            MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS
Sbjct: 1    MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS 60

Query: 61   SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL 120
            SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL
Sbjct: 61   SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL 120

Query: 121  SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK 180
            SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK
Sbjct: 121  SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK 180

Query: 181  QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH 240
            QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH
Sbjct: 181  QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH 240

Query: 241  TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT 300
            TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT
Sbjct: 241  TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT 300

Query: 301  REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD 360
            REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD
Sbjct: 301  REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD 360

Query: 361  IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW 420
            IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW
Sbjct: 361  IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW 420

Query: 421  RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN 480
            RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN
Sbjct: 421  RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN 480

Query: 481  LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA 540
            LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA
Sbjct: 481  LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA 540

Query: 541  VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS 600
            VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS
Sbjct: 541  VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS 600

Query: 601  EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY 660
            EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY
Sbjct: 601  EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY 660

Query: 661  QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML 720
            QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML
Sbjct: 661  QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML 720

Query: 721  QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF 780
            QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF
Sbjct: 721  QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF 780

Query: 781  PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN 840
            PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN
Sbjct: 781  PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN 840

Query: 841  VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG 900
            VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG
Sbjct: 841  VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG 900

Query: 901  LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL 960
            LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL
Sbjct: 901  LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL 960

Query: 961  KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVE 1020
            KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVE
Sbjct: 961  KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVE 1020

Query: 1021 SLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW 1080
            SLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW
Sbjct: 1021 SLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW 1080

Query: 1081 EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK 1140
            EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK
Sbjct: 1081 EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK 1140

Query: 1141 SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS 1200
            SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS
Sbjct: 1141 SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS 1200

Query: 1201 SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLP 1260
            SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLP
Sbjct: 1201 SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLP 1260

Query: 1261 LLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLL 1320
            LLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLL
Sbjct: 1261 LLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLL 1320

Query: 1321 VFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC 1353
            VFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC
Sbjct: 1321 VFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC 1353


>gi|126032348 hect domain and RLD 2 [Homo sapiens]
          Length = 4834

 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 72/246 (29%), Positives = 109/246 (44%), Gaps = 14/246 (5%)

Query: 114  IQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFS 173
            I+   G+  +D+      +  V   T   D+YTWG      LGH     +  P+LV+   
Sbjct: 4085 IESLRGIEVVDVAAGGAHSACV---TAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQ 4141

Query: 174  RSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQ 233
               +           ++ L+    V++ G G  G+LG G    C VP  ++ L G    +
Sbjct: 4142 GHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVK 4201

Query: 234  VAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGR 293
            V      +V LT+ G VYT+G   +H+LG     S  +V R  Q + L+G+ +I +A G 
Sbjct: 4202 VECGSQFSVALTKSGAVYTWGKGDYHRLG---HGSDDHVRRPRQVQGLQGKKVIAIATGS 4258

Query: 294  FHTVLWTREA-VYTMGLNG-GQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGA 351
             H V  T +  VYT G N  GQLG          +  PR V+AL  K +  + VA     
Sbjct: 4259 LHCVCCTEDGEVYTWGDNDEGQLG----DGTTNAIQRPRLVAALQGKKV--NRVACGSAH 4312

Query: 352  TVCVTT 357
            T+  +T
Sbjct: 4313 TLAWST 4318



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 61/223 (27%), Positives = 105/223 (47%), Gaps = 15/223 (6%)

Query: 143 DVYTWGDNTNFTLGHGSQNSKHHPELVDLFS--RSGIYIKQVVLCKFHSVFLSQKGQVYT 200
           +VY+WG      LGHG       P+++  FS  ++G ++  +     +S  ++ +G++YT
Sbjct: 515 EVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYT 574

Query: 201 CGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKD--HTVVLTEDGCVYTFGLNIF 258
            G G  GRLGHG  +   +P LV GL G     VA       T+ +TE+G V+++G   +
Sbjct: 575 WGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDY 634

Query: 259 HQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREA-VYTMGLNGGQLGCL 317
            +LG       C  P+ I+   L+   ++ V  G   ++  T++  VY+ G    Q    
Sbjct: 635 GKLG-RGGSDGCKTPKLIEK--LQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQ---R 688

Query: 318 LDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD 360
           L    E+ V  P+ +  L  K +    +  + G+T C+    D
Sbjct: 689 LGHGTEEHVRYPKLLEGLQGKKV----IDVAAGSTHCLALTED 727



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 59/206 (28%), Positives = 97/206 (47%), Gaps = 18/206 (8%)

Query: 110 VSLYIQDKEGLSALDLVMK--DRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPE 167
           + + +   +GL  +D+     D  T  V +N     V++WGD     LG G  +    P+
Sbjct: 593 IPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQ---VWSWGDGDYGKLGRGGSDGCKTPK 649

Query: 168 LVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLN 227
           L++      + + +V      S+ L++ GQVY+ G G   RLGHG E+    P+L+EGL 
Sbjct: 650 LIEKLQ--DLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQ 707

Query: 228 GHNCSQVAAAKDHTVVLTEDGCVYTFGLN----IFHQLGIIPPPSSCNVPRQIQAKYLKG 283
           G     VAA   H + LTED  V+++G N     F  L +  P  +           L  
Sbjct: 708 GKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAA-------LPGLDT 760

Query: 284 RTIIGVAAGRFHTVLWTREAVYTMGL 309
           + I+G+A G   +  W+  + +++GL
Sbjct: 761 KHIVGIACGPAQSFAWSSCSEWSIGL 786



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 64/222 (28%), Positives = 101/222 (45%), Gaps = 13/222 (5%)

Query: 139  TDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQV 198
            T   ++YTWG      LGHG   ++  P++V +     +           ++ L+ +G V
Sbjct: 3115 TSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLV 3174

Query: 199  YTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIF 258
            ++ G G  G+LG G  + C +P+ +E LNG    Q+      ++ LT+ G V+T+G   +
Sbjct: 3175 FSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDY 3234

Query: 259  HQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREA-VYTMGLNG-GQLGC 316
             +LG     S  +V +    + L+G+ I+ VA G  H +  T    VY  G N  GQ G 
Sbjct: 3235 FRLG---HGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQG- 3290

Query: 317  LLDPNGEKCVT-APRQVSALHHKDIALSLVAASDGATVCVTT 357
                NG   V   P  V  L  + I  + VA     +V  TT
Sbjct: 3291 ----NGTTTVNRKPTLVQGLEGQKI--TRVACGSSHSVAWTT 3326



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 55/168 (32%), Positives = 80/168 (47%), Gaps = 5/168 (2%)

Query: 139  TDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQV 198
            TD   V++WGD     LG G     + P+ ++  +  G+   Q+      S+ L++ G V
Sbjct: 3169 TDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVC--QIECGAQFSLALTKSGVV 3226

Query: 199  YTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIF 258
            +T G G   RLGHG +     P++VEGL G     VA    H + +T+ G VY +G N  
Sbjct: 3227 WTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDH 3286

Query: 259  HQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYT 306
             Q G      +   P  +Q   L+G+ I  VA G  H+V WT   V T
Sbjct: 3287 GQQGNGTTTVN-RKPTLVQG--LEGQKITRVACGSSHSVAWTTVDVAT 3331



 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 67/219 (30%), Positives = 100/219 (45%), Gaps = 16/219 (7%)

Query: 118  EGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGI 177
            E LSAL++V     +  +F  T    VY  G+ TN  LG G  +S   P    + + S  
Sbjct: 2987 ETLSALNVVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGI-SSGTVPIPRQITALSSY 3045

Query: 178  YIKQVVLCKF--HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVA 235
             +K+V +     H+  L+  G+V++ G G  G+LGH     C  PRL+E L       +A
Sbjct: 3046 VVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIA 3105

Query: 236  AAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGR-- 293
                H+  LT  G +YT+GL  + +LG     +    P+ +  K L G  +I VA G   
Sbjct: 3106 CGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLK-PKMV--KVLLGHRVIQVACGSRD 3162

Query: 294  FHTVLWTREA-VYTMG-------LNGGQLGCLLDPNGEK 324
              T+  T E  V++ G         GG  GC +  N E+
Sbjct: 3163 AQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIER 3201



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 53/177 (29%), Positives = 83/177 (46%), Gaps = 7/177 (3%)

Query: 118  EGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGI 177
            E L+ L  V        +F  T    +Y  G      LG G   S   P L++  S   +
Sbjct: 3980 EALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLE--SIQHV 4037

Query: 178  YIKQVVLCKF--HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVA 235
            +IK+V +     H + LS +G+VY+ G    G+LGHG+   C  PR++E L G     VA
Sbjct: 4038 FIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVA 4097

Query: 236  AAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAG 292
            A   H+  +T  G +YT+G   + +LG          P+ ++A  L+G  ++ +A G
Sbjct: 4098 AGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLK-PKLVEA--LQGHRVVDIACG 4151



 Score = 57.4 bits (137), Expect = 9e-08
 Identities = 48/180 (26%), Positives = 79/180 (43%), Gaps = 11/180 (6%)

Query: 188 HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQ----VAAAKDHTVV 243
           H + L+  G+VY+ G G GGRLGHGD      P+++   +G    +    +A    ++  
Sbjct: 506 HYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAA 565

Query: 244 LTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHT-VLWTRE 302
           +T +G +YT+G   + +LG     SS +    +    LKG  +I VA G      L   E
Sbjct: 566 ITAEGELYTWGRGNYGRLG---HGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTE 622

Query: 303 AVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIY 362
                    G  G L     + C T P+ +  L  +D+ +  V      ++ +T  G +Y
Sbjct: 623 NGQVWSWGDGDYGKLGRGGSDGCKT-PKLIEKL--QDLDVVKVRCGSQFSIALTKDGQVY 679



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 77/329 (23%), Positives = 132/329 (40%), Gaps = 50/329 (15%)

Query: 155 LGHGSQNSKHHPELVDLFSRSGIY---IKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGH 211
           +G G    K++  ++      G+    + Q+   +   + LS+ G+VYT  +        
Sbjct: 426 IGWGLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYN------- 478

Query: 212 GDEQTCLVPRLVEGLNGHNCSQVAAAKD--HTVVLTEDGCVYTFGLNIFHQLG---IIPP 266
                 L P+LV+GL   N  ++AA  D  H + L   G VY++G     +LG    +P 
Sbjct: 479 ---SDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVP- 534

Query: 267 PSSCNVPRQIQAKYLK--GRTIIGVAAGRFHTVLWTREA-VYTMGL-NGGQLGCLLDPNG 322
                 P+ I A   K  G+ ++ +A G  ++   T E  +YT G  N G+LG       
Sbjct: 535 ---LEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLG----HGS 587

Query: 323 EKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKM---ASKQLNL 379
            +    P  V+ L    +      + D  T+ VT  G ++   D    K+    S     
Sbjct: 588 SEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKT 647

Query: 380 KKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW-RSVNSSL---KQCRWAYP 435
            K++      E   D + +K   G +  I A+   G+V+ W +  N  L    +    YP
Sbjct: 648 PKLI------EKLQDLDVVKVRCGSQFSI-ALTKDGQVYSWGKGDNQRLGHGTEEHVRYP 700

Query: 436 RQV------FISDIALNRNEILFVTQDGE 458
           + +       + D+A      L +T+D E
Sbjct: 701 KLLEGLQGKKVIDVAAGSTHCLALTEDSE 729



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 61/231 (26%), Positives = 94/231 (40%), Gaps = 20/231 (8%)

Query: 197  QVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLN 256
            +V+  G     +LG        VP   E L+  N  QVA        +T +G VY  G  
Sbjct: 2960 KVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEA 3019

Query: 257  IFHQLGIIPPPSSCNVPRQIQA--KYLKGRTIIGVAAGRFHTVLWTREAVYTMGL-NGGQ 313
               +LG+     +  +PRQI A   Y+  +  +  + GR  T L     V++ G  + G+
Sbjct: 3020 TNGRLGLGISSGTVPIPRQITALSSYVVKKVAVH-SGGRHATALTVDGKVFSWGEGDDGK 3078

Query: 314  LGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMA 373
            LG     N +K    PR + AL  K I    +A     +  +T+ G++Y     +  ++ 
Sbjct: 3079 LGHFSRMNCDK----PRLIEALKTKRI--RDIACGSSHSAALTSSGELYTWGLGEYGRLG 3132

Query: 374  ----SKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW 420
                + QL  K V V  GH   +V        G +    LA+   G VF W
Sbjct: 3133 HGDNTTQLKPKMVKVLLGHRVIQV------ACGSRDAQTLALTDEGLVFSW 3177



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 49/171 (28%), Positives = 73/171 (42%), Gaps = 13/171 (7%)

Query: 196  GQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGL 255
            G +Y  GH   G+LG  +     VP   E L      Q+   +     +T DG +Y  G 
Sbjct: 3952 GTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGY 4011

Query: 256  NIFHQLGI--IPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREA-VYTMG-LNG 311
                +LGI      S+  +   IQ  ++K    + V +G  H +  + E  VY+ G    
Sbjct: 4012 GAGGRLGIGGTESVSTPTLLESIQHVFIKK---VAVNSGGKHCLALSSEGEVYSWGEAED 4068

Query: 312  GQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIY 362
            G+LG     N   C   PR + +L  + I +  VAA    + CVT  GD+Y
Sbjct: 4069 GKLG---HGNRSPC-DRPRVIESL--RGIEVVDVAAGGAHSACVTAAGDLY 4113


>gi|7657152 hect domain and RLD 3 [Homo sapiens]
          Length = 1050

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 84/287 (29%), Positives = 133/287 (46%), Gaps = 24/287 (8%)

Query: 103 WSLLKHGVSLYIQDKEGLSALDLVMKDRPT--------HVVFKNTDPTDVYTWGDNTNFT 154
           WSL + G+S  +Q       +   + DR          H VF   D  +VYT G NT   
Sbjct: 7   WSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDG-EVYTCGLNTKGQ 65

Query: 155 LGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLG-HGD 213
           LGH  + +K  PE +   +    +I  V   + HS+ LS +GQ+++ G G  G+LG    
Sbjct: 66  LGHEREGNK--PEQIGALADQ--HIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTT 121

Query: 214 EQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVP 273
           E +  VPRL++ LN     QV+    H + L  DG  +T+G N   QLG+     S   P
Sbjct: 122 EDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASP 181

Query: 274 RQIQAKYLKGRTIIGVAAGRFHT-VLWTREAVYTMGL-NGGQLGCLLDPNGEKCVTAPRQ 331
           +++++  L+G  +  VAAG  H+  L    AV+  G+ N GQLG     + EK   +P  
Sbjct: 182 QRVRS--LEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGL----SDEKDRESPCH 235

Query: 332 VSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQLN 378
           V  L  + +    ++  +  T  +T  G ++      C ++    +N
Sbjct: 236 VKLLRTQKVV--YISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMN 280



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 58/175 (33%), Positives = 83/175 (47%), Gaps = 9/175 (5%)

Query: 145 YTWGDNTNFTLGHGSQ-NSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGH 203
           +TWG N++  LG G +  S+  P+ V   S  GI + QV     HS  LS  G V+  G 
Sbjct: 159 FTWGKNSHGQLGLGKEFPSQASPQRVR--SLEGIPLAQVAAGGAHSFALSLSGAVFGWGM 216

Query: 204 GPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGI 263
              G+LG  DE+    P  V+ L       ++  ++HT VLT+ G V+TFG     QLG 
Sbjct: 217 NNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGH 276

Query: 264 IPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREA--VYTMGLNG-GQLG 315
                  N  R ++   L G  +  +A GR HT+ +   +  +Y  G    GQLG
Sbjct: 277 DSMNDEVNPRRVLE---LMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLG 328



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 62/216 (28%), Positives = 94/216 (43%), Gaps = 31/216 (14%)

Query: 220 PRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAK 279
           P++   ++  +  +VA   +H+V L EDG VYT GLN   QLG        N P QI A 
Sbjct: 25  PQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLG---HEREGNKPEQIGA- 80

Query: 280 YLKGRTIIGVAAGRFHTV-LWTREAVYTMGL-NGGQLGCLLDPNGEKCVTAPRQVSALHH 337
            L  + II VA G  H++ L  R  +++ G  + GQLG +     E  V  PR +  L+ 
Sbjct: 81  -LADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLM---TTEDSVAVPRLIQKLNQ 136

Query: 338 KDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEH 397
           +    +++  S G   C+    D      +   K +  QL L K   S      +  P+ 
Sbjct: 137 Q----TILQVSCGNWHCLALAADGQF---FTWGKNSHGQLGLGKEFPS------QASPQR 183

Query: 398 LKENGGQKICILAMDGA--------GRVFCWRSVNS 425
           ++   G  +  +A  GA        G VF W   N+
Sbjct: 184 VRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNA 219



 Score = 40.4 bits (93), Expect = 0.012
 Identities = 28/97 (28%), Positives = 45/97 (46%), Gaps = 3/97 (3%)

Query: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSV-FLSQKGQVYTCG 202
           V+T+G  +   LGH S N + +P  V      G  + Q+   + H++ F+   G +Y  G
Sbjct: 263 VFTFGAGSCGQLGHDSMNDEVNPRRV--LELMGSEVTQIACGRQHTLAFVPSSGLIYAFG 320

Query: 203 HGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKD 239
            G  G+LG G       P  V+G    +  Q++A  D
Sbjct: 321 CGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARAD 357


>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
          Length = 4861

 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 68/221 (30%), Positives = 106/221 (47%), Gaps = 16/221 (7%)

Query: 139 TDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQ- 197
           T+  ++YTWG+     LGHG  NS++ P LV   S  G    +V     H++ LS+ G+ 
Sbjct: 527 TEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVG----EVSCGSSHTIALSKDGRT 582

Query: 198 VYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNI 257
           V++ G G  G+LGHGD      P+++E L G    +V A    ++ LT  G VY +G   
Sbjct: 583 VWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGA 642

Query: 258 FHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTRE-AVYTMGLNG-GQLG 315
              LG     ++   P+ I+   L    I+ V+ G  H +  + +  VY  G N  GQ G
Sbjct: 643 C--LGCGSSEATALRPKLIEE--LAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCG 698

Query: 316 CLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVT 356
                N    +T P++VS L    IA+  ++A    ++  T
Sbjct: 699 ---QGNSTGPITKPKKVSGL--DGIAIQQISAGTSHSLAWT 734



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 70/228 (30%), Positives = 112/228 (49%), Gaps = 24/228 (10%)

Query: 139 TDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKF----HSVFLSQ 194
           T   +V++WGD     LGHG+ +++ +P+L+      G    +VV+C      HS  +++
Sbjct: 474 TTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQ-----GPLQGKVVVCVSAGYRHSAAVTE 528

Query: 195 KGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDG-CVYTF 253
            G++YT G G  GRLGHGD  +  +P LV+ ++  N  +V+    HT+ L++DG  V++F
Sbjct: 529 DGELYTWGEGDFGRLGHGDSNSRNIPTLVKDIS--NVGEVSCGSSHTIALSKDGRTVWSF 586

Query: 254 GLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREA-VYTMGLNGG 312
           G     +LG     +    P+ I+A  L+G  I  V AG   ++  T    VY  G  G 
Sbjct: 587 GGGDNGKLG-HGDTNRVYKPKVIEA--LQGMFIRKVCAGSQSSLALTSTGQVYAWGC-GA 642

Query: 313 QLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD 360
            LGC    + E     P+ +  L     A  +V  S G + C+    D
Sbjct: 643 CLGC---GSSEATALRPKLIEEL----AATRIVDVSIGDSHCLALSHD 683



 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 61/222 (27%), Positives = 104/222 (46%), Gaps = 11/222 (4%)

Query: 144  VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLC---KFHSVFLSQKGQVYT 200
            V   G+ +   LG G+ +  H   L  + +  G  + Q+V       HS+ L++ G+V++
Sbjct: 4048 VLACGEGSYGRLGQGNSDDLH--VLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFS 4105

Query: 201  CGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQ 260
             G G  G+LGHG+      PR +E L G    Q++    H+ V+T DG ++TFG   + +
Sbjct: 4106 WGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGR 4165

Query: 261  LGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQLGCLLDP 320
            LG +   S+  +P ++ A  L+G  I  VA G  HT+  + +         G  G  L  
Sbjct: 4166 LG-LGNTSNKKLPERVTA--LEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYG-KLGL 4221

Query: 321  NGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIY 362
                  ++P+++  L    I +  VA     +V +T  G +Y
Sbjct: 4222 GNSTAKSSPQKIDVL--CGIGIKKVACGTQFSVALTKDGHVY 4261



 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 51/170 (30%), Positives = 82/170 (48%), Gaps = 7/170 (4%)

Query: 132 THVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVF 191
           +H +  + D   V+++G   N  LGHG  N  + P++++  +  G++I++V      S+ 
Sbjct: 571 SHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIE--ALQGMFIRKVCAGSQSSLA 628

Query: 192 LSQKGQVYTCGHGPGGRLGHG-DEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCV 250
           L+  GQVY    G G  LG G  E T L P+L+E L       V+    H + L+ D  V
Sbjct: 629 LTSTGQVY--AWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEV 686

Query: 251 YTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT 300
           Y +G N   Q G          P+++    L G  I  ++AG  H++ WT
Sbjct: 687 YAWGNNSMGQCGQGNSTGPITKPKKVSG--LDGIAIQQISAGTSHSLAWT 734



 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 81/344 (23%), Positives = 140/344 (40%), Gaps = 67/344 (19%)

Query: 139 TDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFS-----RSGIY--------------- 178
           ++  +VY WG N++  L  G+Q     P+L   FS      +G Y               
Sbjct: 369 SETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACG 428

Query: 179 ----------------------------IKQVVLCKF---HSVFLSQKGQVYTCGHGPGG 207
                                       IK+V   K    H++  + +G+V++ G G  G
Sbjct: 429 KGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYG 488

Query: 208 RLGHGDEQTCLVPRLVEG-LNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPP 266
           +LGHG+  T   P+L++G L G     V+A   H+  +TEDG +YT+G   F +LG    
Sbjct: 489 KLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLG-HGD 547

Query: 267 PSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCV 326
            +S N+P  ++     G     V+ G  HT+  +++        GG  G L   +  + V
Sbjct: 548 SNSRNIPTLVKDISNVGE----VSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNR-V 602

Query: 327 TAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSG 386
             P+ + AL  + + +  V A   +++ +T+ G +Y      C    S +    +  +  
Sbjct: 603 YKPKVIEAL--QGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKL-- 658

Query: 387 GHMEYKVDPEHLKENGGQKICILAMDGAGRVFCWRSVNSSLKQC 430
             +E       +  + G   C LA+     V+ W   N+S+ QC
Sbjct: 659 --IEELAATRIVDVSIGDSHC-LALSHDNEVYAWG--NNSMGQC 697



 Score = 70.9 bits (172), Expect = 8e-12
 Identities = 52/172 (30%), Positives = 81/172 (47%), Gaps = 5/172 (2%)

Query: 133  HVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFL 192
            H +  + D + V+ +GD     LG G+  +K  P+ +D+    GI IK+V      SV L
Sbjct: 4197 HTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLC--GIGIKKVACGTQFSVAL 4254

Query: 193  SQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYT 252
            ++ G VYT G      L  G  +    P+ +  L G     VA   +HT+ L  +G VY 
Sbjct: 4255 TKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYA 4314

Query: 253  FGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAV 304
            +G N   QLG+     + +V        L+G+ +  ++AGR H+  WT   V
Sbjct: 4315 WGSNSEGQLGL---GHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPV 4363



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 85/311 (27%), Positives = 130/311 (41%), Gaps = 23/311 (7%)

Query: 8    CTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVSSCGKKGV 67
            C   C  +  A   +    +GS  ++    S   +    I  + G     LV+SCG  G 
Sbjct: 4034 CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGH 4093

Query: 68   LDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDLVM 127
               L + G      D + G       + +G+ D      +      I+  +G   + +  
Sbjct: 4094 SMALTESGEVFSWGDGDYG------KLGHGNSD------RQRRPRQIEALQGEEVVQMSC 4141

Query: 128  KDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKF 187
              + + VV   T    ++T+G+     LG G+ ++K  PE V      G  I QV     
Sbjct: 4142 GFKHSAVV---TSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALE--GYQIGQVACGLN 4196

Query: 188  HSVFLSQKGQ-VYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTE 246
            H++ +S  G  V+  G G  G+LG G+      P+ ++ L G    +VA     +V LT+
Sbjct: 4197 HTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTK 4256

Query: 247  DGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTV-LWTREAVY 305
            DG VYTFG +   +L  +P   + N  R  Q   L G  I  VA G  HT+ L +   VY
Sbjct: 4257 DGHVYTFGQD---RLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVY 4313

Query: 306  TMGLNG-GQLG 315
              G N  GQLG
Sbjct: 4314 AWGSNSEGQLG 4324



 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 68/232 (29%), Positives = 109/232 (46%), Gaps = 28/232 (12%)

Query: 143  DVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQ-KGQVYTC 201
            DVY WG   +  L    +N    P     FS++     Q V+C  +  F+ Q  G V  C
Sbjct: 3998 DVYLWGAGRHGQLAEAGRNVMV-PAAAPSFSQA-----QQVICGQNCTFVIQANGTVLAC 4051

Query: 202  GHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQV---AAAKDHTVVLTEDGCVYTFGLNIF 258
            G G  GRLG G+     V  ++  L G   +Q+     +  H++ LTE G V+++G   +
Sbjct: 4052 GEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDY 4111

Query: 259  HQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREA-VYTMGLNG--GQLG 315
             +LG          PRQI+A  L+G  ++ ++ G  H+ + T +  ++T G NG  G+LG
Sbjct: 4112 GKLG-HGNSDRQRRPRQIEA--LQGEEVVQMSCGFKHSAVVTSDGKLFTFG-NGDYGRLG 4167

Query: 316  CLLDPNGEKCVTAPRQVSALHHKDIAL-------SLVAASDGATVCVTTRGD 360
             L + + +K    P +V+AL    I         +L  ++DG+ V     GD
Sbjct: 4168 -LGNTSNKK---LPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGD 4215


>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
          Length = 1049

 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 61/178 (34%), Positives = 86/178 (48%), Gaps = 9/178 (5%)

Query: 142 TDVYTWGDNTNFTLGHGSQNSKH-HPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYT 200
           ++V+ WG N    LG G+   K   P+L  L S  GI   QV     HS  L+  G ++ 
Sbjct: 156 SEVFCWGQNKYGQLGLGTDCKKQTSPQL--LKSLLGIPFMQVAAGGAHSFVLTLSGAIFG 213

Query: 201 CGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQ 260
            G    G+LG  DE    VP L++ L       +   +DHT  LT++G V+TFG   + Q
Sbjct: 214 WGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQ 273

Query: 261 LGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREA--VYTMGLNG-GQLG 315
           LG        N PR++    L G  +  +A GR HT  +   +  +Y+ GL G GQLG
Sbjct: 274 LGHNSTSHEIN-PRKVFE--LMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLG 328



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 69/220 (31%), Positives = 104/220 (47%), Gaps = 15/220 (6%)

Query: 147 WGDNTNFTLGHGSQNSKH--HPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHG 204
           WG+ +   LG G  + +    P   D F    +  + V     H+VF+   G VYTCG  
Sbjct: 4   WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRV--RDVGCGLRHTVFVLDDGTVYTCGCN 61

Query: 205 PGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGII 264
             G+LGH  E++   P  V  L+  N   V+  + HT+ L + G VY +GL+   QLG++
Sbjct: 62  DLGQLGH--EKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLV 119

Query: 265 PPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREA-VYTMGLNG-GQLGCLLDPNG 322
                  VPR I  K L    I+ VA G +H++  ++ + V+  G N  GQLG   D   
Sbjct: 120 GSEECIRVPRNI--KSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDC-- 175

Query: 323 EKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIY 362
            K  T+P+ + +L    I    VAA    +  +T  G I+
Sbjct: 176 -KKQTSPQLLKSL--LGIPFMQVAAGGAHSFVLTLSGAIF 212



 Score = 38.9 bits (89), Expect = 0.034
 Identities = 25/83 (30%), Positives = 40/83 (48%), Gaps = 3/83 (3%)

Query: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFH-SVFLSQKGQVYTCG 202
           V+T+G      LGH S + + +P  V  F   G  + ++   + H S F+   G++Y+ G
Sbjct: 263 VFTFGAGGYGQLGHNSTSHEINPRKV--FELMGSIVTEIACGRQHTSAFVPSSGRIYSFG 320

Query: 203 HGPGGRLGHGDEQTCLVPRLVEG 225
            G  G+LG G       P  V+G
Sbjct: 321 LGGNGQLGTGSTSNRKSPFTVKG 343


>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
          Length = 1057

 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 61/178 (34%), Positives = 86/178 (48%), Gaps = 9/178 (5%)

Query: 142 TDVYTWGDNTNFTLGHGSQNSKH-HPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYT 200
           ++V+ WG N    LG G+   K   P+L  L S  GI   QV     HS  L+  G ++ 
Sbjct: 156 SEVFCWGQNKYGQLGLGTDCKKQTSPQL--LKSLLGIPFMQVAAGGAHSFVLTLSGAIFG 213

Query: 201 CGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQ 260
            G    G+LG  DE    VP L++ L       +   +DHT  LT++G V+TFG   + Q
Sbjct: 214 WGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQ 273

Query: 261 LGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREA--VYTMGLNG-GQLG 315
           LG        N PR++    L G  +  +A GR HT  +   +  +Y+ GL G GQLG
Sbjct: 274 LGHNSTSHEIN-PRKVFE--LMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLG 328



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 69/220 (31%), Positives = 104/220 (47%), Gaps = 15/220 (6%)

Query: 147 WGDNTNFTLGHGSQNSKH--HPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHG 204
           WG+ +   LG G  + +    P   D F    +  + V     H+VF+   G VYTCG  
Sbjct: 4   WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRV--RDVGCGLRHTVFVLDDGTVYTCGCN 61

Query: 205 PGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGII 264
             G+LGH  E++   P  V  L+  N   V+  + HT+ L + G VY +GL+   QLG++
Sbjct: 62  DLGQLGH--EKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLV 119

Query: 265 PPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREA-VYTMGLNG-GQLGCLLDPNG 322
                  VPR I  K L    I+ VA G +H++  ++ + V+  G N  GQLG   D   
Sbjct: 120 GSEECIRVPRNI--KSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDC-- 175

Query: 323 EKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIY 362
            K  T+P+ + +L    I    VAA    +  +T  G I+
Sbjct: 176 -KKQTSPQLLKSL--LGIPFMQVAAGGAHSFVLTLSGAIF 212



 Score = 38.9 bits (89), Expect = 0.034
 Identities = 25/83 (30%), Positives = 40/83 (48%), Gaps = 3/83 (3%)

Query: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFH-SVFLSQKGQVYTCG 202
           V+T+G      LGH S + + +P  V  F   G  + ++   + H S F+   G++Y+ G
Sbjct: 263 VFTFGAGGYGQLGHNSTSHEINPRKV--FELMGSIVTEIACGRQHTSAFVPSSGRIYSFG 320

Query: 203 HGPGGRLGHGDEQTCLVPRLVEG 225
            G  G+LG G       P  V+G
Sbjct: 321 LGGNGQLGTGSTSNRKSPFTVKG 343


>gi|110825982 hect domain and RLD 5 [Homo sapiens]
          Length = 1024

 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 56/177 (31%), Positives = 91/177 (51%), Gaps = 9/177 (5%)

Query: 143 DVYTWGDNTNFTLGHGSQ-NSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTC 201
           +++ WG N +  LG G +  S   P++V+  +  G+ + Q+   + HS+ LS  G +Y+ 
Sbjct: 158 ELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLA--GVPLAQISAGEAHSMALSMSGNIYSW 215

Query: 202 GHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQL 261
           G    G+LG G  ++   P L+EGL+      VA    H+ +LT+DG ++TFG     QL
Sbjct: 216 GKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQL 275

Query: 262 GIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTRE--AVYTMGL-NGGQLG 315
           G     S+ N  R      L G  +  +A GR+HT+ +  +   V++ G    GQLG
Sbjct: 276 G---HNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLG 329



 Score = 57.8 bits (138), Expect = 7e-08
 Identities = 44/140 (31%), Positives = 76/140 (54%), Gaps = 6/140 (4%)

Query: 179 IKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDE-QTCLVPRLVEGLNGHNCSQVAAA 237
           I Q+    +HS+ LS+ G+++  G    G+LG G +  +   P++VE L G   +Q++A 
Sbjct: 140 IIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAG 199

Query: 238 KDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTV 297
           + H++ L+  G +Y++G N   QLG +    S + P  I+   L  + +  VA G  H+ 
Sbjct: 200 EAHSMALSMSGNIYSWGKNECGQLG-LGHTESKDDPSLIEG--LDNQKVEFVACGGSHSA 256

Query: 298 LWTREA-VYTMGL-NGGQLG 315
           L T++  ++T G    GQLG
Sbjct: 257 LLTQDGLLFTFGAGKHGQLG 276



 Score = 39.7 bits (91), Expect = 0.020
 Identities = 23/78 (29%), Positives = 44/78 (56%), Gaps = 3/78 (3%)

Query: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSV-FLSQKGQVYTCG 202
           ++T+G   +  LGH S  ++  P LV      G  + Q+   ++H++ ++S  G+V++ G
Sbjct: 264 LFTFGAGKHGQLGHNSTQNELRPCLVA--ELVGYRVTQIACGRWHTLAYVSDLGKVFSFG 321

Query: 203 HGPGGRLGHGDEQTCLVP 220
            G  G+LG+G  +  L+P
Sbjct: 322 SGKDGQLGNGGTRDQLMP 339



 Score = 36.2 bits (82), Expect = 0.22
 Identities = 45/207 (21%), Positives = 83/207 (40%), Gaps = 36/207 (17%)

Query: 210 GHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSS 269
           G G  +T    +L + +  H+  Q A   +H ++L+ DG  + +       L        
Sbjct: 81  GSGGARTPKCIKLGKNMKIHSVDQGA---EHMLILSSDGKPFEYDNYSMKHLRF------ 131

Query: 270 CNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREA-VYTMGLN-GGQLGCLLDPNGEKCVT 327
                      L+ + II +  G +H++  ++   ++  G N  GQLG      G K  +
Sbjct: 132 --------ESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGV-----GRKFPS 178

Query: 328 APRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGG 387
                   H   + L+ ++A +  ++ ++  G+IY     +C      QL L       G
Sbjct: 179 TTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECG-----QLGL-------G 226

Query: 388 HMEYKVDPEHLKENGGQKICILAMDGA 414
           H E K DP  ++    QK+  +A  G+
Sbjct: 227 HTESKDDPSLIEGLDNQKVEFVACGGS 253


>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
          Length = 522

 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 79/290 (27%), Positives = 131/290 (45%), Gaps = 37/290 (12%)

Query: 175 SGIYIKQVVL--CKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCS 232
           +G+ ++ VV   C  HS+ ++ +G++++ G    G+LGHGD +    PRL+EGL+     
Sbjct: 146 AGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIV 205

Query: 233 QVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAG 292
             A  ++HT+ LTE G V+ FG N   QLG+     +   P QI      G+ I  +A G
Sbjct: 206 SAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIM---YNGQPITKMACG 262

Query: 293 -RFHTVLWTREAVYTMGL-NGGQLGCLLDPNGEKCVTAPR--QVSALHHKDIALSLVAAS 348
             F  ++  +  +Y+ G    GQLG   + +G+    A R      L  + +A+ +    
Sbjct: 263 AEFSMIMDCKGNLYSFGCPEYGQLG--HNSDGKFIARAQRIEYDCELVPRRVAIFIEKTK 320

Query: 349 DGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSG--------GHMEYKVD--PEHL 398
           DG  + V       ++ D  C    +  L+ +K + S         GH E K +  P  +
Sbjct: 321 DGQILPVPN----VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLV 376

Query: 399 K-----ENGGQKI-----CILAMDGAGRVFCWRSVNSSLKQCRWAYPRQV 438
           K       G  +I     C  A+   G +F W + N+S +     YP+ V
Sbjct: 377 KLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSREST--MYPKAV 424



 Score = 54.3 bits (129), Expect = 8e-07
 Identities = 49/196 (25%), Positives = 89/196 (45%), Gaps = 27/196 (13%)

Query: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGH 203
           +++WG N    LGHG       P L++  S     I      + H++ L++ G V+  G 
Sbjct: 171 LWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHE--VIVSAACGRNHTLALTETGSVFAFGE 228

Query: 204 GPGGRLGHGDEQTCLVPRLVEGL-NGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLG 262
              G+LG G+ QT  VP   + + NG   +++A   + ++++   G +Y+FG   + QLG
Sbjct: 229 NKMGQLGLGN-QTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLG 287

Query: 263 -------------------IIPPPSSCNVPRQIQAKYLKGRTII--GVAAGRFHT-VLWT 300
                              ++P   +  + +    + L    ++   VA G  HT VL +
Sbjct: 288 HNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDS 347

Query: 301 REAVYTMGLNG-GQLG 315
           ++ V++ G  G G+LG
Sbjct: 348 QKRVFSWGFGGYGRLG 363



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 38/159 (23%), Positives = 63/159 (39%), Gaps = 7/159 (4%)

Query: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGH 203
           V++WG      LGH  Q  +  P LV LF   G    Q+      S  +S+ G ++  G 
Sbjct: 351 VFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGA 410

Query: 204 GPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGI 263
               R      ++ + P+ V+ L G     +A  K   +V  ++  +       F +LG 
Sbjct: 411 TNTSR------ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGY 464

Query: 264 IPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTRE 302
                  +   Q + K L G     VA G  H+++  R+
Sbjct: 465 GDHKPKSSTAAQ-EVKTLDGIFSEQVAMGYSHSLVIARD 502


>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
          Length = 522

 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 79/290 (27%), Positives = 131/290 (45%), Gaps = 37/290 (12%)

Query: 175 SGIYIKQVVL--CKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCS 232
           +G+ ++ VV   C  HS+ ++ +G++++ G    G+LGHGD +    PRL+EGL+     
Sbjct: 146 AGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIV 205

Query: 233 QVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAG 292
             A  ++HT+ LTE G V+ FG N   QLG+     +   P QI      G+ I  +A G
Sbjct: 206 SAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIM---YNGQPITKMACG 262

Query: 293 -RFHTVLWTREAVYTMGL-NGGQLGCLLDPNGEKCVTAPR--QVSALHHKDIALSLVAAS 348
             F  ++  +  +Y+ G    GQLG   + +G+    A R      L  + +A+ +    
Sbjct: 263 AEFSMIMDCKGNLYSFGCPEYGQLG--HNSDGKFIARAQRIEYDCELVPRRVAIFIEKTK 320

Query: 349 DGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSG--------GHMEYKVD--PEHL 398
           DG  + V       ++ D  C    +  L+ +K + S         GH E K +  P  +
Sbjct: 321 DGQILPVPN----VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLV 376

Query: 399 K-----ENGGQKI-----CILAMDGAGRVFCWRSVNSSLKQCRWAYPRQV 438
           K       G  +I     C  A+   G +F W + N+S +     YP+ V
Sbjct: 377 KLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSREST--MYPKAV 424



 Score = 54.3 bits (129), Expect = 8e-07
 Identities = 49/196 (25%), Positives = 89/196 (45%), Gaps = 27/196 (13%)

Query: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGH 203
           +++WG N    LGHG       P L++  S     I      + H++ L++ G V+  G 
Sbjct: 171 LWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHE--VIVSAACGRNHTLALTETGSVFAFGE 228

Query: 204 GPGGRLGHGDEQTCLVPRLVEGL-NGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLG 262
              G+LG G+ QT  VP   + + NG   +++A   + ++++   G +Y+FG   + QLG
Sbjct: 229 NKMGQLGLGN-QTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLG 287

Query: 263 -------------------IIPPPSSCNVPRQIQAKYLKGRTII--GVAAGRFHT-VLWT 300
                              ++P   +  + +    + L    ++   VA G  HT VL +
Sbjct: 288 HNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDS 347

Query: 301 REAVYTMGLNG-GQLG 315
           ++ V++ G  G G+LG
Sbjct: 348 QKRVFSWGFGGYGRLG 363



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 38/159 (23%), Positives = 63/159 (39%), Gaps = 7/159 (4%)

Query: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGH 203
           V++WG      LGH  Q  +  P LV LF   G    Q+      S  +S+ G ++  G 
Sbjct: 351 VFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGA 410

Query: 204 GPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGI 263
               R      ++ + P+ V+ L G     +A  K   +V  ++  +       F +LG 
Sbjct: 411 TNTSR------ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGY 464

Query: 264 IPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTRE 302
                  +   Q + K L G     VA G  H+++  R+
Sbjct: 465 GDHKPKSSTAAQ-EVKTLDGIFSEQVAMGYSHSLVIARD 502


>gi|4557445 regulator of chromosome condensation and BTB domain
           containing protein 2 [Homo sapiens]
          Length = 551

 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 62/189 (32%), Positives = 92/189 (48%), Gaps = 14/189 (7%)

Query: 133 HVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQV--VLC-KFHS 189
           H+V   T+  +V+TWG N    LG+G+ N      LV     + +  KQV  V C  +HS
Sbjct: 110 HIVLATTEG-EVFTWGHNAYSQLGNGTTNHG----LVPCHISTNLSNKQVIEVACGSYHS 164

Query: 190 VFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEG-LNGHNCSQVAAAKDHTVVLTEDG 248
           + L+  G+V+  G+   G++G G      +PR V G L       +A  +   + + + G
Sbjct: 165 LVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTG 224

Query: 249 CVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREA-VYTM 307
            VY +G N   QLG+    +S N P   +   L+G  +  VA G  HT++ T E  VY  
Sbjct: 225 EVYVWGYNGNGQLGL---GNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAW 281

Query: 308 GLNG-GQLG 315
           G N  GQLG
Sbjct: 282 GANSYGQLG 290



 Score = 57.4 bits (137), Expect = 9e-08
 Identities = 47/184 (25%), Positives = 87/184 (47%), Gaps = 24/184 (13%)

Query: 190 VFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVA-AAKDHTVVLTEDG 248
           ++ +   +++  G    G LG GD Q+ + PR ++ LNG   + ++  +  H V+ T +G
Sbjct: 59  LYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEG 118

Query: 249 CVYTFGLNIFHQL-------GIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTR 301
            V+T+G N + QL       G++P   S N         L  + +I VA G +H+++ T 
Sbjct: 119 EVFTWGHNAYSQLGNGTTNHGLVPCHISTN---------LSNKQVIEVACGSYHSLVLTS 169

Query: 302 EA-VYTMGL-NGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRG 359
           +  V+  G  N GQ+G     N       PR+V+      + ++ +A      + V   G
Sbjct: 170 DGEVFAWGYNNSGQVGSGSTVN----QPIPRRVTGCLQNKVVVT-IACGQMCCMAVVDTG 224

Query: 360 DIYL 363
           ++Y+
Sbjct: 225 EVYV 228



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 38/148 (25%), Positives = 67/148 (45%), Gaps = 9/148 (6%)

Query: 775 VDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVV 834
           VDGK    HK +L  R E+F S L  +  +    +    P++    +  L+YLYTD   +
Sbjct: 400 VDGKYIYAHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVY----RAFLEYLYTDSISL 455

Query: 835 IKESQNVDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLS 894
             E         +L +A      RLK++C+  + + +  +NA  LL  A  Y A+ L+  
Sbjct: 456 SPEEA-----VGLLDLATFYRENRLKKLCQQTIKQGICEENAIALLSAAVKYDAQDLEEF 510

Query: 895 CLQFIGLNMAALLEARSLDVLSDGVLKD 922
           C +F   ++  + +      +   +LK+
Sbjct: 511 CFRFCINHLTVVTQTSGFAEMDHDLLKN 538



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 37/116 (31%), Positives = 53/116 (45%), Gaps = 3/116 (2%)

Query: 140 DPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVY 199
           D  +VY WG N N  LG G  NS + P    + +  GI +++V     H++ L+ +GQVY
Sbjct: 222 DTGEVYVWGYNGNGQLGLG--NSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVY 279

Query: 200 TCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHT-VVLTEDGCVYTFG 254
             G    G+LG G++     P  V           A    HT    T+ G VY +G
Sbjct: 280 AWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335


>gi|8922528 kelch-like 11 [Homo sapiens]
          Length = 708

 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 52/171 (30%), Positives = 81/171 (47%), Gaps = 15/171 (8%)

Query: 761 QKKCSFLCDVTM--KSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHS- 817
           Q++    CD+T+      G+EF  H+ VL A  EYF  +LS  + E+ S   +EM   S 
Sbjct: 87  QRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRS-GRVEMRKWSS 145

Query: 818 ------DILKVILDYLYTDEAVVIKESQNVDFICSVLVVADQLLITRLKEICEVALTEKL 871
                 D ++ +++Y+YT    V   S     +  VL +AD+ L+ RLKE C   L +KL
Sbjct: 146 EPGPEPDTVEAVIEYMYTGRIRVSTGS-----VHEVLELADRFLLIRLKEFCGEFLKKKL 200

Query: 872 TLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKD 922
            L N   +   A MY+  QL L     I  N   +++      L   +++D
Sbjct: 201 HLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHLIRD 251


>gi|6912330 deafness locus associated putative guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 458

 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 63/237 (26%), Positives = 109/237 (45%), Gaps = 11/237 (4%)

Query: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGH 203
           ++ WG N+   LG G +     P+ ++ F +    ++++     HS  ++  G ++ CG 
Sbjct: 17  LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRS-VRRITGGGGHSAVVTDGGDLFVCGL 75

Query: 204 GPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGI 263
              G+LG G  +        + L G    QVA   D T++LTE+G V + G N F QLG+
Sbjct: 76  NKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGV 135

Query: 264 IPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREA-VYTMGLNGGQLGCLLDPNG 322
              P  C VP+ I+   L    ++ +AAG  H V  T    V+  G      G  L P  
Sbjct: 136 PHGPRRCVVPQAIE---LHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQ 192

Query: 323 EK----CVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASK 375
                     P +V+ L +   A+ ++A SD  +  +T  G++Y+    +  ++A++
Sbjct: 193 TLPLFFTAKEPSRVTGLENSK-AMCVLAGSD-HSASLTDAGEVYVWGSNKHGQLANE 247



 Score = 33.1 bits (74), Expect = 1.9
 Identities = 22/77 (28%), Positives = 36/77 (46%), Gaps = 3/77 (3%)

Query: 188 HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEG--LNGHNCSQVAAAKDHTVVLT 245
           HS  L+  G+VY  G    G+L + +     VP+ +E         + + +   H V  T
Sbjct: 223 HSASLTDAGEVYVWGSNKHGQLAN-EAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQT 281

Query: 246 EDGCVYTFGLNIFHQLG 262
           E G ++T+G   + QLG
Sbjct: 282 ETGKMFTWGRADYGQLG 298


>gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo
           sapiens]
          Length = 1052

 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 56/193 (29%), Positives = 89/193 (46%), Gaps = 8/193 (4%)

Query: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGH 203
           V++WGD     LG G     + P+ ++  +  G+   Q+       + L++ G V+T G 
Sbjct: 677 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVC--QIECGAQFLLALTKSGVVWTWGK 734

Query: 204 GPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGI 263
           G   RLGH  +     P++VEGL G     VA    H + + + G VY +G N   Q G 
Sbjct: 735 GDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG- 793

Query: 264 IPPPSSCNVPRQ-IQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQL-GCLLDPN 321
                +  V R+ +  + L+G+ I+ VA G  H+V WT   V T  ++   L     DP 
Sbjct: 794 ---NGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTTMDVATPSVHEPVLFQTARDPL 850

Query: 322 GEKCVTAPRQVSA 334
           G   +  P  V++
Sbjct: 851 GASYLGVPSDVNS 863



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 51/165 (30%), Positives = 75/165 (45%), Gaps = 13/165 (7%)

Query: 196 GQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGL 255
           G V++ G G  G+LG G  + C +P+ +E LNG    Q+       + LT+ G V+T+G 
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 734

Query: 256 NIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTV-LWTREAVYTMGLNG-GQ 313
             + +LG     S  +V +    + L+G+ I+ VA G  H + +     VY  G N  GQ
Sbjct: 735 GDYFRLG---HRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 791

Query: 314 LGCLLDPNGEKCVT-APRQVSALHHKDIALSLVAASDGATVCVTT 357
            G     NG   V   P  V  L  + I    VA     +V  TT
Sbjct: 792 QG-----NGTTTVNRKPMLVQGLEGQKI--MCVACGSSHSVAWTT 829


>gi|56117834 speckle-type POZ protein [Homo sapiens]
          Length = 374

 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 54/201 (26%), Positives = 95/201 (47%), Gaps = 18/201 (8%)

Query: 744 EKINVIAKNTGNKLKLSQKKC----------SFLCDVTMKSVDGKEFPCHKCVLCARLEY 793
           + +N+  +NT N +K+ + +           S   D  +  V G+EF  HK +L AR   
Sbjct: 166 DSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCL-CVAGQEFQAHKAILAARSPV 224

Query: 794 FHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICS-VLVVAD 852
           F +M      E+         +  ++ K ++ ++YT +A       N+D +   +L  AD
Sbjct: 225 FSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKA------PNLDKMADDLLAAAD 278

Query: 853 QLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSL 912
           +  + RLK +CE AL   L+++NAA +L  A ++SA QLK   + FI  + + +LE    
Sbjct: 279 KYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLETSGW 338

Query: 913 DVLSDGVLKDLSEFYRKMIPA 933
             +       ++E YR +  A
Sbjct: 339 KSMVVSHPHLVAEAYRSLASA 359


>gi|56117832 speckle-type POZ protein [Homo sapiens]
          Length = 374

 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 54/201 (26%), Positives = 95/201 (47%), Gaps = 18/201 (8%)

Query: 744 EKINVIAKNTGNKLKLSQKKC----------SFLCDVTMKSVDGKEFPCHKCVLCARLEY 793
           + +N+  +NT N +K+ + +           S   D  +  V G+EF  HK +L AR   
Sbjct: 166 DSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCL-CVAGQEFQAHKAILAARSPV 224

Query: 794 FHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICS-VLVVAD 852
           F +M      E+         +  ++ K ++ ++YT +A       N+D +   +L  AD
Sbjct: 225 FSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKA------PNLDKMADDLLAAAD 278

Query: 853 QLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSL 912
           +  + RLK +CE AL   L+++NAA +L  A ++SA QLK   + FI  + + +LE    
Sbjct: 279 KYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLETSGW 338

Query: 913 DVLSDGVLKDLSEFYRKMIPA 933
             +       ++E YR +  A
Sbjct: 339 KSMVVSHPHLVAEAYRSLASA 359


>gi|56117830 speckle-type POZ protein [Homo sapiens]
          Length = 374

 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 54/201 (26%), Positives = 95/201 (47%), Gaps = 18/201 (8%)

Query: 744 EKINVIAKNTGNKLKLSQKKC----------SFLCDVTMKSVDGKEFPCHKCVLCARLEY 793
           + +N+  +NT N +K+ + +           S   D  +  V G+EF  HK +L AR   
Sbjct: 166 DSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCL-CVAGQEFQAHKAILAARSPV 224

Query: 794 FHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICS-VLVVAD 852
           F +M      E+         +  ++ K ++ ++YT +A       N+D +   +L  AD
Sbjct: 225 FSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKA------PNLDKMADDLLAAAD 278

Query: 853 QLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSL 912
           +  + RLK +CE AL   L+++NAA +L  A ++SA QLK   + FI  + + +LE    
Sbjct: 279 KYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLETSGW 338

Query: 913 DVLSDGVLKDLSEFYRKMIPA 933
             +       ++E YR +  A
Sbjct: 339 KSMVVSHPHLVAEAYRSLASA 359


>gi|56117828 speckle-type POZ protein [Homo sapiens]
          Length = 374

 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 54/201 (26%), Positives = 95/201 (47%), Gaps = 18/201 (8%)

Query: 744 EKINVIAKNTGNKLKLSQKKC----------SFLCDVTMKSVDGKEFPCHKCVLCARLEY 793
           + +N+  +NT N +K+ + +           S   D  +  V G+EF  HK +L AR   
Sbjct: 166 DSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCL-CVAGQEFQAHKAILAARSPV 224

Query: 794 FHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICS-VLVVAD 852
           F +M      E+         +  ++ K ++ ++YT +A       N+D +   +L  AD
Sbjct: 225 FSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKA------PNLDKMADDLLAAAD 278

Query: 853 QLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSL 912
           +  + RLK +CE AL   L+++NAA +L  A ++SA QLK   + FI  + + +LE    
Sbjct: 279 KYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLETSGW 338

Query: 913 DVLSDGVLKDLSEFYRKMIPA 933
             +       ++E YR +  A
Sbjct: 339 KSMVVSHPHLVAEAYRSLASA 359


>gi|4507183 speckle-type POZ protein [Homo sapiens]
          Length = 374

 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 54/201 (26%), Positives = 95/201 (47%), Gaps = 18/201 (8%)

Query: 744 EKINVIAKNTGNKLKLSQKKC----------SFLCDVTMKSVDGKEFPCHKCVLCARLEY 793
           + +N+  +NT N +K+ + +           S   D  +  V G+EF  HK +L AR   
Sbjct: 166 DSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCL-CVAGQEFQAHKAILAARSPV 224

Query: 794 FHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICS-VLVVAD 852
           F +M      E+         +  ++ K ++ ++YT +A       N+D +   +L  AD
Sbjct: 225 FSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKA------PNLDKMADDLLAAAD 278

Query: 853 QLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSL 912
           +  + RLK +CE AL   L+++NAA +L  A ++SA QLK   + FI  + + +LE    
Sbjct: 279 KYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLETSGW 338

Query: 913 DVLSDGVLKDLSEFYRKMIPA 933
             +       ++E YR +  A
Sbjct: 339 KSMVVSHPHLVAEAYRSLASA 359


>gi|56117836 speckle-type POZ protein [Homo sapiens]
          Length = 374

 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 54/201 (26%), Positives = 95/201 (47%), Gaps = 18/201 (8%)

Query: 744 EKINVIAKNTGNKLKLSQKKC----------SFLCDVTMKSVDGKEFPCHKCVLCARLEY 793
           + +N+  +NT N +K+ + +           S   D  +  V G+EF  HK +L AR   
Sbjct: 166 DSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCL-CVAGQEFQAHKAILAARSPV 224

Query: 794 FHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICS-VLVVAD 852
           F +M      E+         +  ++ K ++ ++YT +A       N+D +   +L  AD
Sbjct: 225 FSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKA------PNLDKMADDLLAAAD 278

Query: 853 QLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSL 912
           +  + RLK +CE AL   L+++NAA +L  A ++SA QLK   + FI  + + +LE    
Sbjct: 279 KYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLETSGW 338

Query: 913 DVLSDGVLKDLSEFYRKMIPA 933
             +       ++E YR +  A
Sbjct: 339 KSMVVSHPHLVAEAYRSLASA 359


>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
           sapiens]
          Length = 596

 Score = 70.9 bits (172), Expect = 8e-12
 Identities = 56/193 (29%), Positives = 88/193 (45%), Gaps = 8/193 (4%)

Query: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGH 203
           V++WGD     LG G     + P+ ++  +  G+   Q+       + L++ G V+T G 
Sbjct: 25  VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVC--QIECGAQFLLALTKSGVVWTWGK 82

Query: 204 GPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGI 263
           G   RLGH  +     P++VEGL G     VA    H + + + G VY +G N   Q G 
Sbjct: 83  GDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG- 141

Query: 264 IPPPSSCNVPRQ-IQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQL-GCLLDPN 321
                +  V R+    + L+G+ I+ VA G  H+V WT   V T  ++   L     DP 
Sbjct: 142 ---NGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPL 198

Query: 322 GEKCVTAPRQVSA 334
           G   +  P  V++
Sbjct: 199 GASYLGVPSDVNS 211



 Score = 57.8 bits (138), Expect = 7e-08
 Identities = 50/163 (30%), Positives = 74/163 (45%), Gaps = 13/163 (7%)

Query: 198 VYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNI 257
           V++ G G  G+LG G  + C +P+ +E LNG    Q+       + LT+ G V+T+G   
Sbjct: 25  VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84

Query: 258 FHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTV-LWTREAVYTMGLNG-GQLG 315
           + +LG     S  +V +    + L+G+ I+ VA G  H + +     VY  G N  GQ G
Sbjct: 85  YFRLG---HRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141

Query: 316 CLLDPNGEKCVT-APRQVSALHHKDIALSLVAASDGATVCVTT 357
                NG   V   P  V  L  + I    VA     +V  TT
Sbjct: 142 -----NGTTTVNRKPTLVQGLEGQKI--MCVACGSSHSVAWTT 177


>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
          Length = 692

 Score = 70.9 bits (172), Expect = 8e-12
 Identities = 69/266 (25%), Positives = 114/266 (42%), Gaps = 24/266 (9%)

Query: 110 VSLYIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELV 169
           +S +++ + G++   +   D  T  +   TD   + T+G  +N  LGHGS      P +V
Sbjct: 381 ISRFLEGQSGVTIKHVACGDFFTACL---TDRGIIMTFGSGSNGCLGHGSLTDISQPTIV 437

Query: 170 DLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGH 229
           +     G  + QV     H + LS + +++  G G  GRLG G  ++   P+ V    G 
Sbjct: 438 EALL--GYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQ 495

Query: 230 NCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIP-PPSSCNVPRQ----------IQA 278
              +V    D +++LT  G     G N F++LG+         VP Q          + +
Sbjct: 496 EAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGS 555

Query: 279 KYLKGRTIIGVAAGRFHTVLWTREA-VYTMGLN-GGQLGCLLDPNGEKCVTAPRQVSALH 336
             L    ++ +  G  H+   T     YT G N  GQLG     N  +   AP +V  L 
Sbjct: 556 APLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLG----TNTRRGSRAPCKVQGL- 610

Query: 337 HKDIALSLVAASDGATVCVTTRGDIY 362
            + I +++VA  D  TV +    ++Y
Sbjct: 611 -EGIKMAMVACGDAFTVAIGAESEVY 635



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 31/100 (31%), Positives = 49/100 (49%), Gaps = 2/100 (2%)

Query: 166 PELVDLF--SRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLV 223
           P+ +  F   +SG+ IK V    F +  L+ +G + T G G  G LGHG       P +V
Sbjct: 378 PQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIV 437

Query: 224 EGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGI 263
           E L G+   QVA    H + L+ +  ++ +G     +LG+
Sbjct: 438 EALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGL 477



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 31/114 (27%), Positives = 48/114 (42%), Gaps = 2/114 (1%)

Query: 188 HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTED 247
           HS  ++  G  YT G    G+LG    +    P  V+GL G   + VA     TV +  +
Sbjct: 572 HSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAE 631

Query: 248 GCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTR 301
             VY++G     +LG         +PR +Q       T+  V+    +T+L  R
Sbjct: 632 SEVYSWGKGARGRLG--RRDEDAGLPRPVQLDETHPYTVTSVSCCHGNTLLAVR 683



 Score = 38.1 bits (87), Expect = 0.058
 Identities = 27/82 (32%), Positives = 38/82 (46%), Gaps = 3/82 (3%)

Query: 143 DVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCG 202
           D YT+G N +  LG  ++     P  V      GI +  V      +V +  + +VY+ G
Sbjct: 581 DCYTFGSNQHGQLGTNTRRGSRAPCKVQ--GLEGIKMAMVACGDAFTVAIGAESEVYSWG 638

Query: 203 HGPGGRLGHGDEQTCLVPRLVE 224
            G  GRLG  DE   L PR V+
Sbjct: 639 KGARGRLGRRDEDAGL-PRPVQ 659



 Score = 33.9 bits (76), Expect = 1.1
 Identities = 33/118 (27%), Positives = 50/118 (42%), Gaps = 7/118 (5%)

Query: 202 GHGPGGRLGHGDEQTC--LVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFH 259
           G G G  L    EQ     + R +EG +G     VA     T  LT+ G + TFG     
Sbjct: 362 GAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSG--- 418

Query: 260 QLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTV-LWTREAVYTMGL-NGGQLG 315
             G +   S  ++ +    + L G  ++ VA G  H + L T   ++  G  + G+LG
Sbjct: 419 SNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLG 476


>gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo
           sapiens]
          Length = 1102

 Score = 67.8 bits (164), Expect = 7e-11
 Identities = 55/193 (28%), Positives = 88/193 (45%), Gaps = 8/193 (4%)

Query: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGH 203
           V++WGD     LG G     + P+ ++  +  G+   Q+       + L++ G V+T G 
Sbjct: 727 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVC--QIECGAQFLLALTKSGVVWTWGK 784

Query: 204 GPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGI 263
           G   RLGH  +      ++VEGL G     VA    H + + + G VY +G N   Q G 
Sbjct: 785 GDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG- 843

Query: 264 IPPPSSCNVPRQ-IQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQL-GCLLDPN 321
                +  V R+ +  + L+G+ I+ VA G  H+V WT   V T  ++   L     DP 
Sbjct: 844 ---NGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTTMDVATPSVHEPVLFQTARDPL 900

Query: 322 GEKCVTAPRQVSA 334
           G   +  P  V++
Sbjct: 901 GASYLGVPSDVNS 913



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 51/165 (30%), Positives = 75/165 (45%), Gaps = 13/165 (7%)

Query: 196 GQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGL 255
           G V++ G G  G+LG G  + C +P+ +E LNG    Q+       + LT+ G V+T+G 
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 784

Query: 256 NIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTV-LWTREAVYTMGLNG-GQ 313
             + +LG     S  +V +    + L+G+ I+ VA G  H + +     VY  G N  GQ
Sbjct: 785 GDYFRLG---HRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 841

Query: 314 LGCLLDPNGEKCVT-APRQVSALHHKDIALSLVAASDGATVCVTT 357
            G     NG   V   P  V  L  + I    VA     +V  TT
Sbjct: 842 QG-----NGTTTVNRKPMLVQGLEGQKI--MCVACGSSHSVAWTT 879


>gi|148664209 kelch-like 10 [Homo sapiens]
          Length = 608

 Score = 67.4 bits (163), Expect = 9e-11
 Identities = 56/183 (30%), Positives = 88/183 (48%), Gaps = 13/183 (7%)

Query: 745 KINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIE 804
           K++ +A    N+L+L  K    LCDV +K V+G EF  HK +LC+   YF ++ +S W  
Sbjct: 20  KMSAMACEIFNELRLEGK----LCDVVIK-VNGFEFSAHKNILCSCSSYFRALFTSGWNN 74

Query: 805 ASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICSVLVVADQLLITRLKEICE 864
                     I  D++K+I++Y YT    +  +  NV+    +L  ADQ  I  +   C 
Sbjct: 75  TEKKVYNIPGISPDMMKLIIEYAYTRTVPITPD--NVE---KLLAAADQFNIMGIVRGCC 129

Query: 865 VALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLE--ARSLDVLSDGVLKD 922
             L  +L L N   + +F   Y   +L+     FI  N   +++  A  L+ LS   LKD
Sbjct: 130 EFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLE-LSVTELKD 188

Query: 923 LSE 925
           + E
Sbjct: 189 IIE 191



 Score = 36.6 bits (83), Expect = 0.17
 Identities = 22/75 (29%), Positives = 35/75 (46%), Gaps = 13/75 (17%)

Query: 565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSAGCHLFVVEKVH 624
           DV  +V    F AHK IL   S +F+ LF S  N +E               ++ +  + 
Sbjct: 40  DVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKK-------------VYNIPGIS 86

Query: 625 PDMFEYLLQFIYTDT 639
           PDM + ++++ YT T
Sbjct: 87  PDMMKLIIEYAYTRT 101


>gi|126116565 MYC binding protein 2 [Homo sapiens]
          Length = 4640

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 40/81 (49%), Positives = 49/81 (60%), Gaps = 2/81 (2%)

Query: 183 VLCKFH-SVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHT 241
           V C FH SV L + G VYT G+G  G+LGHGD  +   P LV+ L G + +QV A  +HT
Sbjct: 907 VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTAGSNHT 965

Query: 242 VVLTEDGCVYTFGLNIFHQLG 262
            VL  DG V+TFG     QLG
Sbjct: 966 AVLLMDGQVFTFGSFSKGQLG 986



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 40/147 (27%), Positives = 62/147 (42%), Gaps = 23/147 (15%)

Query: 143  DVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCG 202
            DVYT+G   +  LGHG  NS+  P LV           QV     H+  L   GQV+T G
Sbjct: 922  DVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS---TQVTAGSNHTAVLLMDGQVFTFG 978

Query: 203  HGPGGRLG-------HGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGL 255
                G+LG       + + +   +P  +    G   + + A+ D T +  ++  + +  L
Sbjct: 979  SFSKGQLGRPILDVPYWNAKPAPMPN-IGSKYGRKATWIGASGDQTFLRIDEALINSHVL 1037

Query: 256  ---NIF---HQLGII------PPPSSC 270
                IF   H +G++      PPP  C
Sbjct: 1038 ATSEIFASKHIIGLVPASISEPPPFKC 1064



 Score = 39.7 bits (91), Expect = 0.020
 Identities = 21/41 (51%), Positives = 26/41 (63%)

Query: 222 LVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLG 262
           LV  L GH  +QVA  K HT VL ++G V+TFG+N   Q G
Sbjct: 636 LVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCG 676



 Score = 37.4 bits (85), Expect = 0.099
 Identities = 36/85 (42%), Positives = 44/85 (51%), Gaps = 6/85 (7%)

Query: 233 QVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAG 292
           QV+    H+VVL E+G VYTFG     QLG     +S   P  +QA  L G +   V AG
Sbjct: 906 QVSCGFHHSVVLMENGDVYTFGYGQHGQLG-HGDVNSRGCPTLVQA--LPGPS-TQVTAG 961

Query: 293 RFHT-VLWTREAVYTMG-LNGGQLG 315
             HT VL     V+T G  + GQLG
Sbjct: 962 SNHTAVLLMDGQVFTFGSFSKGQLG 986


>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
          Length = 979

 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 65/255 (25%), Positives = 111/255 (43%), Gaps = 29/255 (11%)

Query: 129 DRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFH 188
           + P  VV   T  ++VY WG              K  P+ +D+  +SG   +QV     H
Sbjct: 336 EAPIAVVTSRT--SEVYVWG------------GGKSTPQKLDVI-KSGCSARQVCAGNTH 380

Query: 189 SVFLSQKGQVYTCGHGPGG-----RLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVV 243
              ++ + ++YT  +  GG     +LGHGD+ +   P+ VE L G    QV+   D TV 
Sbjct: 381 FAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVC 440

Query: 244 LTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTR-E 302
           +T++G +Y FG + +  +G +   +   V   +Q  +     +  V+ G  H V+ TR +
Sbjct: 441 VTDEGQLYAFGSDYYGCMG-VDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNK 499

Query: 303 AVYTMGLNG-GQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDI 361
            VY+ G    G+LG     + E+    P++V     K + +  V      T  +T  G +
Sbjct: 500 EVYSWGCGEYGRLGL----DSEEDYYTPQKVDV--PKALIIVAVQCGCDGTFLLTQSGKV 553

Query: 362 YLLADYQCKKMASKQ 376
                 +  K+   Q
Sbjct: 554 LACGLNEFNKLGLNQ 568



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 58/225 (25%), Positives = 89/225 (39%), Gaps = 26/225 (11%)

Query: 133 HVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFL 192
           HVV   T   +VY+WG      LG  S+   + P+ VD+       I   V C     FL
Sbjct: 491 HVVVL-TRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDV---PKALIIVAVQCGCDGTFL 546

Query: 193 -SQKGQVYTCGHGPGGRLGHGDEQTCLVPR-------------LVEGLNGHNCSQVAAAK 238
            +Q G+V  CG     +LG     + ++               L + L+ +    +A  K
Sbjct: 547 LTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGK 606

Query: 239 DHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVL 298
            HT  + E G + TFG N   QLG+        +   +    L G+ +I V+ G   T+ 
Sbjct: 607 THTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGI--NLLGGPLGGKQVIRVSCGDEFTIA 664

Query: 299 WTREAVYTMGLNGGQLGCLLDP-----NGEKCVTAPRQV-SALHH 337
            T +       NGG     + P       + C + PR +  +LHH
Sbjct: 665 ATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHH 709


>gi|45333883 kelch repeat and BTB (POZ) domain-containing 6 [Homo
           sapiens]
          Length = 674

 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 51/187 (27%), Positives = 85/187 (45%), Gaps = 19/187 (10%)

Query: 751 KNTGNKLKLSQKKCSF-----LCDVTMKSVD-------GKEFPCHKCVLCARLEYFHSML 798
           K+T +   L  +  SF     LCDVT++ V        G+ FPC++ VL A   YF SM 
Sbjct: 41  KDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMF 100

Query: 799 SSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICSVLVVADQLLITR 858
           +    E+   +     + ++  +V++DY YT    V     NV+    +   +D L +  
Sbjct: 101 TGGMYESQQASVTMHDVDAESFEVLVDYCYTGR--VSLSEANVE---RLYAASDMLQLEY 155

Query: 859 LKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSL--DVLS 916
           ++E C   L  +L L N   +L+FA  +  ++L+     +I  N   L    S+  + L+
Sbjct: 156 VREACASFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLA 215

Query: 917 DGVLKDL 923
           D  L  L
Sbjct: 216 DLTLAQL 222


>gi|109150407 kelch-like 6 [Homo sapiens]
          Length = 621

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 49/171 (28%), Positives = 81/171 (47%), Gaps = 10/171 (5%)

Query: 739 VRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSML 798
           V+F++  +++I +N    L++       L DV +  VD +EF CH+ VL A   YF +M 
Sbjct: 47  VKFDDAGLSLILQNGLETLRMENA----LTDVIL-CVDIQEFSCHRVVLAAASNYFRAMF 101

Query: 799 SSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICSVLVVADQLLITR 858
            +   E      +   + ++ +  +LDY YT +A++ K  QNV     VL  A+     R
Sbjct: 102 CNDLKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITK--QNVQ---RVLEAANLFQFLR 156

Query: 859 LKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEA 909
           + + C   LTE L  +N   +L  A  +S   LK     +I  N   +L +
Sbjct: 157 MVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNS 207


>gi|48717263 speckle-type POZ protein-like [Homo sapiens]
          Length = 392

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 47/153 (30%), Positives = 78/153 (50%), Gaps = 15/153 (9%)

Query: 749 IAKNTGNKLKLSQ-KKCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASS 807
           +A++ GN  + ++   CSF        V G+EF  HK VL AR   F++M      E+  
Sbjct: 186 LAEDLGNLWENTRFTDCSFF-------VRGQEFKAHKSVLAARSPVFNAMFEHEMEESKK 238

Query: 808 CAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFIC-SVLVVADQLLITRLKEICEVA 866
                  +  ++ K ++ ++YT  A       N+D +  ++L  AD+  + RLK +CE A
Sbjct: 239 NRVEINDLDPEVFKEMMRFIYTGRA------PNLDKMADNLLAAADKYALERLKVMCEEA 292

Query: 867 LTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFI 899
           L   L+++N A  L  A ++SA+QLK   + FI
Sbjct: 293 LCSNLSVENVADTLVLADLHSAEQLKAQAIDFI 325



 Score = 33.1 bits (74), Expect = 1.9
 Identities = 21/73 (28%), Positives = 34/73 (46%), Gaps = 13/73 (17%)

Query: 565 DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSAGCHLFVVEKVH 624
           D +F V  + F AHK +LA  S  F  +F  +   S+   +   D D             
Sbjct: 201 DCSFFVRGQEFKAHKSVLAARSPVFNAMFEHEMEESKKNRVEINDLD------------- 247

Query: 625 PDMFEYLLQFIYT 637
           P++F+ +++FIYT
Sbjct: 248 PEVFKEMMRFIYT 260


>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
           sapiens]
          Length = 815

 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 63/233 (27%), Positives = 101/233 (43%), Gaps = 17/233 (7%)

Query: 138 NTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQ 197
           +T+  +VY  G N    LG G    ++   ++  F+ S   IKQ+      S  L++ G+
Sbjct: 102 STEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFT-SEHKIKQLSAGSNTSAALTEDGR 160

Query: 198 VYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNI 257
           ++  G    G++G  +     VP+ V    G   S ++    H+  +T DG +Y FG   
Sbjct: 161 LFMWGDNSEGQIGLKNVSNVCVPQQVT--IGKPVSWISCGYYHSAFVTTDGELYVFGEPE 218

Query: 258 FHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNG-GQLGC 316
             +LG+  P       R  Q        +I VA G  HTV+ T  AVYT GL   GQLG 
Sbjct: 219 NGKLGL--PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGL 276

Query: 317 ---LLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLAD 366
              L + +  K +         + +D  +S ++  +  T  +T  G +Y   D
Sbjct: 277 GTFLFETSEPKVIE--------NIRDQTISYISCGENHTALITDIGLMYTFGD 321



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 57/227 (25%), Positives = 97/227 (42%), Gaps = 16/227 (7%)

Query: 139 TDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQV 198
           T    +Y +G N    LG GS+++   P  V       +  K     + H++  ++ G V
Sbjct: 51  TGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKV--KLAACGRNHTLVSTEGGNV 108

Query: 199 YTCGHGPGGRLGHGDEQTCLVPRLVEGLNG-HNCSQVAAAKDHTVVLTEDGCVYTFGLNI 257
           Y  G    G+LG GD +      ++      H   Q++A  + +  LTEDG ++ +G N 
Sbjct: 109 YATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNS 168

Query: 258 FHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREA-VYTMG-LNGGQLG 315
             Q+G+    + C VP+Q+      G+ +  ++ G +H+   T +  +Y  G    G+LG
Sbjct: 169 EGQIGLKNVSNVC-VPQQVTI----GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLG 223

Query: 316 CLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIY 362
                 G      P+ VS +  K I +    A  G    V T   +Y
Sbjct: 224 LPNQLLGNH--RTPQLVSEIPEKVIQV----ACGGEHTVVLTENAVY 264



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 44/137 (32%), Positives = 69/137 (50%), Gaps = 14/137 (10%)

Query: 133 HVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHH--PELVDLFSRSGIYIKQVVLCKFHSV 190
           H  F  TD  ++Y +G+  N  LG  +Q   +H  P+LV       I   QV     H+V
Sbjct: 201 HSAFVTTDG-ELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVI---QVACGGEHTV 256

Query: 191 FLSQKGQVYTCGHGPGGRLGHGDEQTCLV----PRLVEGLNGHNCSQVAAAKDHTVVLTE 246
            L++   VYT G G  G+LG G   T L     P+++E +     S ++  ++HT ++T+
Sbjct: 257 VLTENA-VYTFGLGQFGQLGLG---TFLFETSEPKVIENIRDQTISYISCGENHTALITD 312

Query: 247 DGCVYTFGLNIFHQLGI 263
            G +YTFG     +LG+
Sbjct: 313 IGLMYTFGDGRHGKLGL 329



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 25/76 (32%), Positives = 36/76 (47%)

Query: 188 HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTED 247
           HS  ++   ++Y  G    G+LG G +     P  V+ L        A  ++HT+V TE 
Sbjct: 46  HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105

Query: 248 GCVYTFGLNIFHQLGI 263
           G VY  G N   QLG+
Sbjct: 106 GNVYATGGNNEGQLGL 121



 Score = 38.9 bits (89), Expect = 0.034
 Identities = 41/151 (27%), Positives = 66/151 (43%), Gaps = 15/151 (9%)

Query: 234 VAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGR 293
           ++   +H+ V+T +  +Y FG N + QLG+    S   + +    K LK   +   A GR
Sbjct: 40  LSCGDEHSAVVTGNNKLYMFGSNNWGQLGL---GSKSAISKPTCVKALKPEKVKLAACGR 96

Query: 294 FHTVLWTREA-VY-TMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGA 351
            HT++ T    VY T G N GQLG  L    E+            HK   +  ++A    
Sbjct: 97  NHTLVSTEGGNVYATGGNNEGQLG--LGDTEERNTFHVISFFTSEHK---IKQLSAGSNT 151

Query: 352 TVCVTTRGDIYLLADYQCKKMASKQLNLKKV 382
           +  +T  G +++  D      +  Q+ LK V
Sbjct: 152 SAALTEDGRLFMWGD-----NSEGQIGLKNV 177


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 63/233 (27%), Positives = 101/233 (43%), Gaps = 17/233 (7%)

Query: 138 NTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQ 197
           +T+  +VY  G N    LG G    ++   ++  F+ S   IKQ+      S  L++ G+
Sbjct: 102 STEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFT-SEHKIKQLSAGSNTSAALTEDGR 160

Query: 198 VYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNI 257
           ++  G    G++G  +     VP+ V    G   S ++    H+  +T DG +Y FG   
Sbjct: 161 LFMWGDNSEGQIGLKNVSNVCVPQQVT--IGKPVSWISCGYYHSAFVTTDGELYVFGEPE 218

Query: 258 FHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNG-GQLGC 316
             +LG+  P       R  Q        +I VA G  HTV+ T  AVYT GL   GQLG 
Sbjct: 219 NGKLGL--PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGL 276

Query: 317 ---LLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLAD 366
              L + +  K +         + +D  +S ++  +  T  +T  G +Y   D
Sbjct: 277 GTFLFETSEPKVIE--------NIRDQTISYISCGENHTALITDIGLMYTFGD 321



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 57/227 (25%), Positives = 97/227 (42%), Gaps = 16/227 (7%)

Query: 139 TDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQV 198
           T    +Y +G N    LG GS+++   P  V       +  K     + H++  ++ G V
Sbjct: 51  TGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKV--KLAACGRNHTLVSTEGGNV 108

Query: 199 YTCGHGPGGRLGHGDEQTCLVPRLVEGLNG-HNCSQVAAAKDHTVVLTEDGCVYTFGLNI 257
           Y  G    G+LG GD +      ++      H   Q++A  + +  LTEDG ++ +G N 
Sbjct: 109 YATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNS 168

Query: 258 FHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREA-VYTMG-LNGGQLG 315
             Q+G+    + C VP+Q+      G+ +  ++ G +H+   T +  +Y  G    G+LG
Sbjct: 169 EGQIGLKNVSNVC-VPQQVTI----GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLG 223

Query: 316 CLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIY 362
                 G      P+ VS +  K I +    A  G    V T   +Y
Sbjct: 224 LPNQLLGNH--RTPQLVSEIPEKVIQV----ACGGEHTVVLTENAVY 264



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 44/137 (32%), Positives = 69/137 (50%), Gaps = 14/137 (10%)

Query: 133 HVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHH--PELVDLFSRSGIYIKQVVLCKFHSV 190
           H  F  TD  ++Y +G+  N  LG  +Q   +H  P+LV       I   QV     H+V
Sbjct: 201 HSAFVTTDG-ELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVI---QVACGGEHTV 256

Query: 191 FLSQKGQVYTCGHGPGGRLGHGDEQTCLV----PRLVEGLNGHNCSQVAAAKDHTVVLTE 246
            L++   VYT G G  G+LG G   T L     P+++E +     S ++  ++HT ++T+
Sbjct: 257 VLTENA-VYTFGLGQFGQLGLG---TFLFETSEPKVIENIRDQTISYISCGENHTALITD 312

Query: 247 DGCVYTFGLNIFHQLGI 263
            G +YTFG     +LG+
Sbjct: 313 IGLMYTFGDGRHGKLGL 329



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 25/76 (32%), Positives = 36/76 (47%)

Query: 188 HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTED 247
           HS  ++   ++Y  G    G+LG G +     P  V+ L        A  ++HT+V TE 
Sbjct: 46  HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105

Query: 248 GCVYTFGLNIFHQLGI 263
           G VY  G N   QLG+
Sbjct: 106 GNVYATGGNNEGQLGL 121



 Score = 38.9 bits (89), Expect = 0.034
 Identities = 41/151 (27%), Positives = 66/151 (43%), Gaps = 15/151 (9%)

Query: 234 VAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGR 293
           ++   +H+ V+T +  +Y FG N + QLG+    S   + +    K LK   +   A GR
Sbjct: 40  LSCGDEHSAVVTGNNKLYMFGSNNWGQLGL---GSKSAISKPTCVKALKPEKVKLAACGR 96

Query: 294 FHTVLWTREA-VY-TMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGA 351
            HT++ T    VY T G N GQLG  L    E+            HK   +  ++A    
Sbjct: 97  NHTLVSTEGGNVYATGGNNEGQLG--LGDTEERNTFHVISFFTSEHK---IKQLSAGSNT 151

Query: 352 TVCVTTRGDIYLLADYQCKKMASKQLNLKKV 382
           +  +T  G +++  D      +  Q+ LK V
Sbjct: 152 SAALTEDGRLFMWGD-----NSEGQIGLKNV 177


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,229,225
Number of Sequences: 37866
Number of extensions: 2484865
Number of successful extensions: 9098
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 216
Number of HSP's successfully gapped in prelim test: 224
Number of HSP's that attempted gapping in prelim test: 7394
Number of HSP's gapped (non-prelim): 1457
length of query: 1353
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1239
effective length of database: 13,930,794
effective search space: 17260253766
effective search space used: 17260253766
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.