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Search of human proteins with 57863298
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]
(1655 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] 3334 0.0
gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] 3322 0.0
gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] 1935 0.0
gi|78499633 phospholipase C, eta 2 [Homo sapiens] 1214 0.0
gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 340 5e-93
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 340 5e-93
gi|14249340 phospholipase C, delta 4 [Homo sapiens] 337 7e-92
gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 335 2e-91
gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 335 2e-91
gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] 330 9e-90
gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] 330 9e-90
gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] 307 5e-83
gi|19115964 phospholipase C delta 3 [Homo sapiens] 295 2e-79
gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 293 9e-79
gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 293 9e-79
gi|11386139 phospholipase C beta 3 [Homo sapiens] 285 2e-76
gi|25188201 phospholipase C, zeta 1 [Homo sapiens] 244 5e-64
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 238 4e-62
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 238 4e-62
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 235 3e-61
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 174 6e-43
gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso... 174 6e-43
gi|95147333 phospholipase C, beta 2 [Homo sapiens] 169 2e-41
gi|209862851 plastin 3 [Homo sapiens] 45 6e-04
gi|7549809 plastin 3 [Homo sapiens] 45 6e-04
gi|11067753 calcium binding protein 5 [Homo sapiens] 45 8e-04
gi|223278387 calmodulin-like 5 [Homo sapiens] 44 0.001
gi|4885111 calmodulin-like 3 [Homo sapiens] 44 0.002
gi|58218968 calmodulin 3 [Homo sapiens] 42 0.005
gi|4502549 calmodulin 2 [Homo sapiens] 42 0.005
>gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]
Length = 1655
Score = 3334 bits (8645), Expect = 0.0
Identities = 1655/1655 (100%), Positives = 1655/1655 (100%)
Query: 1 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQS 60
MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQS
Sbjct: 1 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQS 60
Query: 61 EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAK 120
EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAK
Sbjct: 61 EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAK 120
Query: 121 RQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGT 180
RQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGT
Sbjct: 121 RQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGT 180
Query: 181 LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDII 240
LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDII
Sbjct: 181 LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDII 240
Query: 241 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL 300
KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL
Sbjct: 241 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL 300
Query: 301 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINK 360
TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINK
Sbjct: 301 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINK 360
Query: 361 HAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGK 420
HAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGK
Sbjct: 361 HAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGK 420
Query: 421 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESL 480
ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESL
Sbjct: 421 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESL 480
Query: 481 LKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKT 540
LKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKT
Sbjct: 481 LKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKT 540
Query: 541 TKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVD 600
TKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVD
Sbjct: 541 TKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVD 600
Query: 601 DGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQ 660
DGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQ
Sbjct: 601 DGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQ 660
Query: 661 LVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKV 720
LVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKV
Sbjct: 661 LVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKV 720
Query: 721 ISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFT 780
ISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFT
Sbjct: 721 ISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFT 780
Query: 781 VHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEI 840
VHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEI
Sbjct: 781 VHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEI 840
Query: 841 YGKNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQE 900
YGKNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQE
Sbjct: 841 YGKNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQE 900
Query: 901 MVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENS 960
MVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENS
Sbjct: 901 MVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENS 960
Query: 961 LAEDKDGRRKGKASIKDPHFLNFNKKLSSSSSALLHKDTSQGDTIVSTAHMSVTGEQLGM 1020
LAEDKDGRRKGKASIKDPHFLNFNKKLSSSSSALLHKDTSQGDTIVSTAHMSVTGEQLGM
Sbjct: 961 LAEDKDGRRKGKASIKDPHFLNFNKKLSSSSSALLHKDTSQGDTIVSTAHMSVTGEQLGM 1020
Query: 1021 SSPRGGRTTSNATSNCQENPCPSKSLSPKQHLAPDPVVNPTQDLHGVKIKEKGNPEDFVE 1080
SSPRGGRTTSNATSNCQENPCPSKSLSPKQHLAPDPVVNPTQDLHGVKIKEKGNPEDFVE
Sbjct: 1021 SSPRGGRTTSNATSNCQENPCPSKSLSPKQHLAPDPVVNPTQDLHGVKIKEKGNPEDFVE 1080
Query: 1081 GKSILSGSVLSHSNLEIKNLEGNRGKGRAATSFSLSDVSMLCSDIPDLHSTAILQESVIS 1140
GKSILSGSVLSHSNLEIKNLEGNRGKGRAATSFSLSDVSMLCSDIPDLHSTAILQESVIS
Sbjct: 1081 GKSILSGSVLSHSNLEIKNLEGNRGKGRAATSFSLSDVSMLCSDIPDLHSTAILQESVIS 1140
Query: 1141 HLIDNVTLTNENEPGSSISALIGQFDETNNQALTVVSHLHNTSVMSGHCPLPSLGLKMPI 1200
HLIDNVTLTNENEPGSSISALIGQFDETNNQALTVVSHLHNTSVMSGHCPLPSLGLKMPI
Sbjct: 1141 HLIDNVTLTNENEPGSSISALIGQFDETNNQALTVVSHLHNTSVMSGHCPLPSLGLKMPI 1200
Query: 1201 KHGFCKGKSKSSFLCSSPELIALSSSETTKHATNTVYETTCTPISKTKPDDDLSSKAKTA 1260
KHGFCKGKSKSSFLCSSPELIALSSSETTKHATNTVYETTCTPISKTKPDDDLSSKAKTA
Sbjct: 1201 KHGFCKGKSKSSFLCSSPELIALSSSETTKHATNTVYETTCTPISKTKPDDDLSSKAKTA 1260
Query: 1261 ALESNLPGSPNTSRGWLPKSPTKGEDWETLKSCSPASSPDLTLEDVIADPTLCFNSGESS 1320
ALESNLPGSPNTSRGWLPKSPTKGEDWETLKSCSPASSPDLTLEDVIADPTLCFNSGESS
Sbjct: 1261 ALESNLPGSPNTSRGWLPKSPTKGEDWETLKSCSPASSPDLTLEDVIADPTLCFNSGESS 1320
Query: 1321 LVEIDGESENLSLTTCEYRREGTSQLASPLKLKYNQGVVEHFQRGLRNGYCKETLRPSVP 1380
LVEIDGESENLSLTTCEYRREGTSQLASPLKLKYNQGVVEHFQRGLRNGYCKETLRPSVP
Sbjct: 1321 LVEIDGESENLSLTTCEYRREGTSQLASPLKLKYNQGVVEHFQRGLRNGYCKETLRPSVP 1380
Query: 1381 EIFNNIQDVKTQSISYLAYQGAGFVHNHFSDSDAKMFQTCVPQQSSAQDMHVPVPKQLAH 1440
EIFNNIQDVKTQSISYLAYQGAGFVHNHFSDSDAKMFQTCVPQQSSAQDMHVPVPKQLAH
Sbjct: 1381 EIFNNIQDVKTQSISYLAYQGAGFVHNHFSDSDAKMFQTCVPQQSSAQDMHVPVPKQLAH 1440
Query: 1441 LPLPALKLPSPCKSKSLGDLTSEDIACNFESKYQCISKSFVTTGIRDKKGVTVKTKSLEP 1500
LPLPALKLPSPCKSKSLGDLTSEDIACNFESKYQCISKSFVTTGIRDKKGVTVKTKSLEP
Sbjct: 1441 LPLPALKLPSPCKSKSLGDLTSEDIACNFESKYQCISKSFVTTGIRDKKGVTVKTKSLEP 1500
Query: 1501 IDALTEQLRKLVSFDQEDNCQVLYSKQDANQLPRALVRKLSSRSQSRVRNIASRAKEKQE 1560
IDALTEQLRKLVSFDQEDNCQVLYSKQDANQLPRALVRKLSSRSQSRVRNIASRAKEKQE
Sbjct: 1501 IDALTEQLRKLVSFDQEDNCQVLYSKQDANQLPRALVRKLSSRSQSRVRNIASRAKEKQE 1560
Query: 1561 ANKQKVPNPSNGAGVVLRNKPSAPTPAVNRHSTGSYIAGYLKNTKGGGLEGRGIPEGACT 1620
ANKQKVPNPSNGAGVVLRNKPSAPTPAVNRHSTGSYIAGYLKNTKGGGLEGRGIPEGACT
Sbjct: 1561 ANKQKVPNPSNGAGVVLRNKPSAPTPAVNRHSTGSYIAGYLKNTKGGGLEGRGIPEGACT 1620
Query: 1621 ALHYGHVDQFCSDNSVLQTEPSSDDKPEIYFLLRL 1655
ALHYGHVDQFCSDNSVLQTEPSSDDKPEIYFLLRL
Sbjct: 1621 ALHYGHVDQFCSDNSVLQTEPSSDDKPEIYFLLRL 1655
>gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]
Length = 1693
Score = 3322 bits (8614), Expect = 0.0
Identities = 1655/1675 (98%), Positives = 1655/1675 (98%), Gaps = 20/1675 (1%)
Query: 1 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQS 60
MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQS
Sbjct: 19 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQS 78
Query: 61 EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAK 120
EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAK
Sbjct: 79 EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAK 138
Query: 121 RQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGT 180
RQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGT
Sbjct: 139 RQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGT 198
Query: 181 LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDII 240
LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDII
Sbjct: 199 LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDII 258
Query: 241 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL 300
KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL
Sbjct: 259 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL 318
Query: 301 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINK 360
TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINK
Sbjct: 319 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINK 378
Query: 361 HAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGK 420
HAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGK
Sbjct: 379 HAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGK 438
Query: 421 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESL 480
ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESL
Sbjct: 439 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESL 498
Query: 481 LKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKT 540
LKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKT
Sbjct: 499 LKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKT 558
Query: 541 TKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVD 600
TKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVD
Sbjct: 559 TKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVD 618
Query: 601 DGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQ 660
DGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQ
Sbjct: 619 DGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQ 678
Query: 661 LVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKV 720
LVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKV
Sbjct: 679 LVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKV 738
Query: 721 ISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFT 780
ISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFT
Sbjct: 739 ISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFT 798
Query: 781 VHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEI 840
VHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEI
Sbjct: 799 VHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEI 858
Query: 841 YG--------------------KNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRIL 880
YG KNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRIL
Sbjct: 859 YGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRIL 918
Query: 881 RRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLL 940
RRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLL
Sbjct: 919 RRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLL 978
Query: 941 GALSLPVSETAKDIEGKENSLAEDKDGRRKGKASIKDPHFLNFNKKLSSSSSALLHKDTS 1000
GALSLPVSETAKDIEGKENSLAEDKDGRRKGKASIKDPHFLNFNKKLSSSSSALLHKDTS
Sbjct: 979 GALSLPVSETAKDIEGKENSLAEDKDGRRKGKASIKDPHFLNFNKKLSSSSSALLHKDTS 1038
Query: 1001 QGDTIVSTAHMSVTGEQLGMSSPRGGRTTSNATSNCQENPCPSKSLSPKQHLAPDPVVNP 1060
QGDTIVSTAHMSVTGEQLGMSSPRGGRTTSNATSNCQENPCPSKSLSPKQHLAPDPVVNP
Sbjct: 1039 QGDTIVSTAHMSVTGEQLGMSSPRGGRTTSNATSNCQENPCPSKSLSPKQHLAPDPVVNP 1098
Query: 1061 TQDLHGVKIKEKGNPEDFVEGKSILSGSVLSHSNLEIKNLEGNRGKGRAATSFSLSDVSM 1120
TQDLHGVKIKEKGNPEDFVEGKSILSGSVLSHSNLEIKNLEGNRGKGRAATSFSLSDVSM
Sbjct: 1099 TQDLHGVKIKEKGNPEDFVEGKSILSGSVLSHSNLEIKNLEGNRGKGRAATSFSLSDVSM 1158
Query: 1121 LCSDIPDLHSTAILQESVISHLIDNVTLTNENEPGSSISALIGQFDETNNQALTVVSHLH 1180
LCSDIPDLHSTAILQESVISHLIDNVTLTNENEPGSSISALIGQFDETNNQALTVVSHLH
Sbjct: 1159 LCSDIPDLHSTAILQESVISHLIDNVTLTNENEPGSSISALIGQFDETNNQALTVVSHLH 1218
Query: 1181 NTSVMSGHCPLPSLGLKMPIKHGFCKGKSKSSFLCSSPELIALSSSETTKHATNTVYETT 1240
NTSVMSGHCPLPSLGLKMPIKHGFCKGKSKSSFLCSSPELIALSSSETTKHATNTVYETT
Sbjct: 1219 NTSVMSGHCPLPSLGLKMPIKHGFCKGKSKSSFLCSSPELIALSSSETTKHATNTVYETT 1278
Query: 1241 CTPISKTKPDDDLSSKAKTAALESNLPGSPNTSRGWLPKSPTKGEDWETLKSCSPASSPD 1300
CTPISKTKPDDDLSSKAKTAALESNLPGSPNTSRGWLPKSPTKGEDWETLKSCSPASSPD
Sbjct: 1279 CTPISKTKPDDDLSSKAKTAALESNLPGSPNTSRGWLPKSPTKGEDWETLKSCSPASSPD 1338
Query: 1301 LTLEDVIADPTLCFNSGESSLVEIDGESENLSLTTCEYRREGTSQLASPLKLKYNQGVVE 1360
LTLEDVIADPTLCFNSGESSLVEIDGESENLSLTTCEYRREGTSQLASPLKLKYNQGVVE
Sbjct: 1339 LTLEDVIADPTLCFNSGESSLVEIDGESENLSLTTCEYRREGTSQLASPLKLKYNQGVVE 1398
Query: 1361 HFQRGLRNGYCKETLRPSVPEIFNNIQDVKTQSISYLAYQGAGFVHNHFSDSDAKMFQTC 1420
HFQRGLRNGYCKETLRPSVPEIFNNIQDVKTQSISYLAYQGAGFVHNHFSDSDAKMFQTC
Sbjct: 1399 HFQRGLRNGYCKETLRPSVPEIFNNIQDVKTQSISYLAYQGAGFVHNHFSDSDAKMFQTC 1458
Query: 1421 VPQQSSAQDMHVPVPKQLAHLPLPALKLPSPCKSKSLGDLTSEDIACNFESKYQCISKSF 1480
VPQQSSAQDMHVPVPKQLAHLPLPALKLPSPCKSKSLGDLTSEDIACNFESKYQCISKSF
Sbjct: 1459 VPQQSSAQDMHVPVPKQLAHLPLPALKLPSPCKSKSLGDLTSEDIACNFESKYQCISKSF 1518
Query: 1481 VTTGIRDKKGVTVKTKSLEPIDALTEQLRKLVSFDQEDNCQVLYSKQDANQLPRALVRKL 1540
VTTGIRDKKGVTVKTKSLEPIDALTEQLRKLVSFDQEDNCQVLYSKQDANQLPRALVRKL
Sbjct: 1519 VTTGIRDKKGVTVKTKSLEPIDALTEQLRKLVSFDQEDNCQVLYSKQDANQLPRALVRKL 1578
Query: 1541 SSRSQSRVRNIASRAKEKQEANKQKVPNPSNGAGVVLRNKPSAPTPAVNRHSTGSYIAGY 1600
SSRSQSRVRNIASRAKEKQEANKQKVPNPSNGAGVVLRNKPSAPTPAVNRHSTGSYIAGY
Sbjct: 1579 SSRSQSRVRNIASRAKEKQEANKQKVPNPSNGAGVVLRNKPSAPTPAVNRHSTGSYIAGY 1638
Query: 1601 LKNTKGGGLEGRGIPEGACTALHYGHVDQFCSDNSVLQTEPSSDDKPEIYFLLRL 1655
LKNTKGGGLEGRGIPEGACTALHYGHVDQFCSDNSVLQTEPSSDDKPEIYFLLRL
Sbjct: 1639 LKNTKGGGLEGRGIPEGACTALHYGHVDQFCSDNSVLQTEPSSDDKPEIYFLLRL 1693
>gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]
Length = 1002
Score = 1935 bits (5012), Expect = 0.0
Identities = 961/983 (97%), Positives = 962/983 (97%), Gaps = 20/983 (2%)
Query: 1 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQS 60
MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQS
Sbjct: 19 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQS 78
Query: 61 EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAK 120
EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAK
Sbjct: 79 EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAK 138
Query: 121 RQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGT 180
RQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGT
Sbjct: 139 RQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGT 198
Query: 181 LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDII 240
LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDII
Sbjct: 199 LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDII 258
Query: 241 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL 300
KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL
Sbjct: 259 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL 318
Query: 301 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINK 360
TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINK
Sbjct: 319 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINK 378
Query: 361 HAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGK 420
HAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGK
Sbjct: 379 HAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGK 438
Query: 421 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESL 480
ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESL
Sbjct: 439 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESL 498
Query: 481 LKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKT 540
LKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKT
Sbjct: 499 LKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKT 558
Query: 541 TKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVD 600
TKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVD
Sbjct: 559 TKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVD 618
Query: 601 DGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQ 660
DGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQ
Sbjct: 619 DGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQ 678
Query: 661 LVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKV 720
LVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKV
Sbjct: 679 LVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKV 738
Query: 721 ISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFT 780
ISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFT
Sbjct: 739 ISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFT 798
Query: 781 VHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEI 840
VHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEI
Sbjct: 799 VHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEI 858
Query: 841 YG--------------------KNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRIL 880
YG KNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRIL
Sbjct: 859 YGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRIL 918
Query: 881 RRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLL 940
RRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLL
Sbjct: 919 RRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLL 978
Query: 941 GALSLPVSETAKDIEGKENSLAE 963
GALSLPVSETAKDIEGKENSL +
Sbjct: 979 GALSLPVSETAKDIEGKENSLVQ 1001
>gi|78499633 phospholipase C, eta 2 [Homo sapiens]
Length = 1416
Score = 1214 bits (3141), Expect = 0.0
Identities = 595/920 (64%), Positives = 737/920 (80%), Gaps = 10/920 (1%)
Query: 1 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQS 60
M MQ G QM+KL+ G+KGLVR +YLDEHR+ +RWRPSRK+EKAKI IDSI +V+EGRQS
Sbjct: 46 MGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEGRQS 105
Query: 61 EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAK 120
E+F R +G+FDP+CCF+IYHG+H ESLDL++++ E ARTW+TGL+YLMAGISDEDSLA+
Sbjct: 106 EVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLAR 165
Query: 121 RQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGT 180
RQRT DQW+KQTF+EADKNGDG L+I E+ QL+HKLNVNLPR++V+QMF+EADTD++QGT
Sbjct: 166 RQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGT 225
Query: 181 LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDII 240
L FEEFC FYKMMS RRDLYLL+L+YS+ KDHL L +FL+VEQKM VT + C DII
Sbjct: 226 LGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDII 285
Query: 241 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL 300
++FE ENK K +LGI+GFTN+ RSPA DIFNP HH V+QDM QPL +Y+I SSHNTYL
Sbjct: 286 EQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYL 345
Query: 301 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINK 360
GDQL+SQS+VDMYA VLQ GCRCVEVDCWDGPDGEP+VHHGYTLTSKILF+DV+ETINK
Sbjct: 346 VGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINK 405
Query: 361 HAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGK 420
+AF+KNE+PVILSIENHCS+ QQ+K+AQYL I GDKLDLSSV + + LPSPQ LKGK
Sbjct: 406 YAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGK 465
Query: 421 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESL 480
ILVKGKKLP ++ +DAEEGEVSDEDSADEI+D+CK L+ T +VE+ ++KL+SL
Sbjct: 466 ILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKL-LNGDASTNRKRVENTAKRKLDSL 524
Query: 481 LKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKE--SGKKSHGRSLMTNFGKHK 538
+KES+IRD EDP++F+V L + G + ++ + E + +GR ++ +F + K
Sbjct: 525 IKESKIRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRK 584
Query: 539 KTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDI 598
K K+ S ++ ++ Q S GGQ R++KTMKL R LSDLV YT SVA DI
Sbjct: 585 KKGSKLKKAASVEEGDEGQDS---PGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDI 641
Query: 599 -VDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNA 657
++ ++ V SFSET+AHQ++QQK Q++ +NQ+QL+RIYPS+YR+DSSN+NP P+WNA
Sbjct: 642 EMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNA 701
Query: 658 GCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLI 717
GCQ+VALNYQSEGRM+QLNRAKF ANG CGYVLKP MC+G FNP S DPLP KKQL+
Sbjct: 702 GCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLKKQLV 761
Query: 718 LKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETL 777
L++ISGQQLPKP DSM GDRGEIIDPFVEVEIIGLPVDC ++QTRVVDDNGFNP WEETL
Sbjct: 762 LRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETL 821
Query: 778 TFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITI 837
F VHMPEIALVRFLVWDHDPIGRDF+GQRT+ FSS++PGYRHVYLEG+ EASIFVH+ +
Sbjct: 822 VFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVHVAV 881
Query: 838 NEIYGKNRQLQGLKGLFNKNPRHSSSENNS--HYVRKRSIGDRILRRTASAPAKGRKKSK 895
++I GK +Q GLKGLF + P+ S ++++ + S+ RILRRTASAP K +K +
Sbjct: 882 SDISGKVKQALGLKGLFLRGPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGR 941
Query: 896 MGFQEMV-EIKDSVSEATRD 914
GF E+V +D+ S+ D
Sbjct: 942 RGFPELVLGTRDTGSKGVAD 961
Score = 67.4 bits (163), Expect = 1e-10
Identities = 64/184 (34%), Positives = 80/184 (43%), Gaps = 44/184 (23%)
Query: 1449 PSPCKSKSLGDLTSEDIACNFESKYQCISKSF-VTTGIRDKKGVTVKTKSLEPIDALTEQ 1507
P KSKSLGDLT++D A +FE + +S S + G R G V+ D LTEQ
Sbjct: 1249 PVAAKSKSLGDLTADDFAPSFEGGSRRLSHSLGLPGGTRRVSGPGVRR------DTLTEQ 1302
Query: 1508 LRKLVSFDQEDNCQVLYSKQDANQLPRA---LVRKLSSRSQSRVRNIASRAKEKQEANKQ 1564
LR L F Q + S A + VR+ SSRS SRVR IASRA++ QE ++
Sbjct: 1303 LRWLTVFQQAGDITSPTSLGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQR 1362
Query: 1565 KVPNPSNGAGVVLRNKPSAPTPAVNRHSTGSYIAGYLKNTKGGGLEGRGIPEGACTALHY 1624
G G +G E RG PEGAC+ H
Sbjct: 1363 -----LQGLG-----------------------------RQGPPEEERGTPEGACSVGHE 1388
Query: 1625 GHVD 1628
G VD
Sbjct: 1389 GSVD 1392
>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
Length = 1127
Score = 340 bits (873), Expect = 5e-93
Identities = 188/453 (41%), Positives = 276/453 (60%), Gaps = 9/453 (1%)
Query: 4 MQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK-SEKAKILIDSIYKVTEGRQSEI 62
M G+++ K++ ++ R F LD LRW PS+K SEKAKI I SI +V G+ ++I
Sbjct: 143 MVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDI 202
Query: 63 FHRQA-EGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMA-GISDEDSLAK 120
F C F++ +G + ESLDL+ ++ + A W+TGL+YL++ G D L
Sbjct: 203 FRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 262
Query: 121 RQ-RTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQ- 178
Q WV Q F E D + G + + Q + LN L K+ F+E +++
Sbjct: 263 SQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKA 322
Query: 179 GT-LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCL 237
GT +T EEF + + R ++Y LL+ +S K+ L ++L FL+ EQ + ++ + L
Sbjct: 323 GTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISL 382
Query: 238 DIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHN 297
+II K+E S+E + K L I+GFTN++ SP C IF+P H +V QDM QPL +Y+I SSHN
Sbjct: 383 EIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHN 442
Query: 298 TYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVET 357
TYL DQ S + Y R L+ GCR VE+D WDGPD EPV++ G+T+TS+I+FR V++
Sbjct: 443 TYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDI 502
Query: 358 INKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSL 417
INK+AF +E+P+IL +ENHCSI+QQ+ + Q++K + GDKL +S + E LPSP L
Sbjct: 503 INKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPSPDVL 561
Query: 418 KGKILVKGKKLPYHLGDDAEEGEVSDEDSADEI 450
KGKIL+K KKL + EG+V+DED E+
Sbjct: 562 KGKILIKAKKLSSNC--SGVEGDVTDEDEGAEM 592
Score = 226 bits (577), Expect = 1e-58
Identities = 135/349 (38%), Positives = 195/349 (55%), Gaps = 24/349 (6%)
Query: 535 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRR---------KTMKLCRELSD 585
GK K S + S + + T + G E Q R+G+ K +LC+ELS+
Sbjct: 563 GKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQ--RMGKENMEQPNNVPVKRFQLCKELSE 620
Query: 586 LVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 642
LV SV ++ V SF+E A + + F+ YN++ L R++PS
Sbjct: 621 LVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPM 680
Query: 643 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--F 700
RIDSSN NP +W GCQ+VA+N+Q+ G MM LN F+ NGNCGYVL+P M + F
Sbjct: 681 RIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFF 740
Query: 701 NPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ 760
+ + D +P + L +K+ISGQ PKP S G +G+++DP+V VEI G+P DC + +
Sbjct: 741 SANTKDSVPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQR 798
Query: 761 TRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRH 820
T+ V NG P+++E+ F +++PE+A+VRF+V D D IG +F+GQ T+ F L GYRH
Sbjct: 799 TKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 858
Query: 821 VYLEGLT-----EASIFVHITI-NEIYGKNRQLQGLKGLFNKNPRHSSS 863
V L+ LT AS+FVH+ I N G +GL K R +S
Sbjct: 859 VPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYAS 907
>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
Length = 1001
Score = 340 bits (873), Expect = 5e-93
Identities = 188/453 (41%), Positives = 276/453 (60%), Gaps = 9/453 (1%)
Query: 4 MQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK-SEKAKILIDSIYKVTEGRQSEI 62
M G+++ K++ ++ R F LD LRW PS+K SEKAKI I SI +V G+ ++I
Sbjct: 17 MVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDI 76
Query: 63 FHRQA-EGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMA-GISDEDSLAK 120
F C F++ +G + ESLDL+ ++ + A W+TGL+YL++ G D L
Sbjct: 77 FRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 136
Query: 121 RQ-RTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQ- 178
Q WV Q F E D + G + + Q + LN L K+ F+E +++
Sbjct: 137 SQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKA 196
Query: 179 GT-LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCL 237
GT +T EEF + + R ++Y LL+ +S K+ L ++L FL+ EQ + ++ + L
Sbjct: 197 GTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISL 256
Query: 238 DIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHN 297
+II K+E S+E + K L I+GFTN++ SP C IF+P H +V QDM QPL +Y+I SSHN
Sbjct: 257 EIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHN 316
Query: 298 TYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVET 357
TYL DQ S + Y R L+ GCR VE+D WDGPD EPV++ G+T+TS+I+FR V++
Sbjct: 317 TYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDI 376
Query: 358 INKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSL 417
INK+AF +E+P+IL +ENHCSI+QQ+ + Q++K + GDKL +S + E LPSP L
Sbjct: 377 INKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPSPDVL 435
Query: 418 KGKILVKGKKLPYHLGDDAEEGEVSDEDSADEI 450
KGKIL+K KKL + EG+V+DED E+
Sbjct: 436 KGKILIKAKKLSSNC--SGVEGDVTDEDEGAEM 466
Score = 226 bits (577), Expect = 1e-58
Identities = 135/349 (38%), Positives = 195/349 (55%), Gaps = 24/349 (6%)
Query: 535 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRR---------KTMKLCRELSD 585
GK K S + S + + T + G E Q R+G+ K +LC+ELS+
Sbjct: 437 GKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQ--RMGKENMEQPNNVPVKRFQLCKELSE 494
Query: 586 LVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 642
LV SV ++ V SF+E A + + F+ YN++ L R++PS
Sbjct: 495 LVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPM 554
Query: 643 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--F 700
RIDSSN NP +W GCQ+VA+N+Q+ G MM LN F+ NGNCGYVL+P M + F
Sbjct: 555 RIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFF 614
Query: 701 NPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ 760
+ + D +P + L +K+ISGQ PKP S G +G+++DP+V VEI G+P DC + +
Sbjct: 615 SANTKDSVPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQR 672
Query: 761 TRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRH 820
T+ V NG P+++E+ F +++PE+A+VRF+V D D IG +F+GQ T+ F L GYRH
Sbjct: 673 TKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 732
Query: 821 VYLEGLT-----EASIFVHITI-NEIYGKNRQLQGLKGLFNKNPRHSSS 863
V L+ LT AS+FVH+ I N G +GL K R +S
Sbjct: 733 VPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYAS 781
>gi|14249340 phospholipase C, delta 4 [Homo sapiens]
Length = 762
Score = 337 bits (863), Expect = 7e-92
Identities = 187/456 (41%), Positives = 277/456 (60%), Gaps = 7/456 (1%)
Query: 3 VMQSGTQMIKLKRGTKGLVRLFYL-DEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSE 61
+MQ G M K++ + +R F L ++ T R +R S K I + + G SE
Sbjct: 17 LMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSE 76
Query: 62 IFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKR 121
+ AE FTI +LDL+ ++ EEA+ W+ GL+ L+ ++ D
Sbjct: 77 LLRSLAE-ELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMD----H 131
Query: 122 QRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTL 181
Q DQW+ F+ DKN DG ++ +E+ +L+H +NV + + +FQ ADT ++ GTL
Sbjct: 132 QERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQS-GTL 190
Query: 182 TFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIK 241
EEF FYK ++ R ++ L S+S LT+ E FL+ EQK + T++ L++I
Sbjct: 191 EGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELID 250
Query: 242 KFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLT 301
++E S+ K+++VL ++GF +++ S DIFNP +YQDM QPL +Y+I SSHNTYL
Sbjct: 251 RYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLV 310
Query: 302 GDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKH 361
GDQL QS V+ Y R L+ GCRCVEVD WDGP GEPVV+HG+TLTS+ILF+DVV T+ ++
Sbjct: 311 GDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQY 370
Query: 362 AFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKI 421
AF +++PVILS+E HCS +QQ+ +A++L I G++L +++D QLPSP+ L+ KI
Sbjct: 371 AFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKI 430
Query: 422 LVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFK 457
LVKGKKL + EE E E E+ E +F+
Sbjct: 431 LVKGKKLTLEEDLEYEEEEAEPELEESELALESQFE 466
Score = 209 bits (531), Expect = 2e-53
Identities = 118/303 (38%), Positives = 180/303 (59%), Gaps = 23/303 (7%)
Query: 548 YSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN- 606
+ T+ E Q K+ +++ LC LS LV+Y SV+ + +
Sbjct: 465 FETEPEPQEQNLQNKDK-------KKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHF 517
Query: 607 --VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVAL 664
+ SFSET+A +++++ +F+ +N QL+R+YPS R DSSN+NP WNAGCQ+VA+
Sbjct: 518 YEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAM 577
Query: 665 NYQSEGRMMQLNRAKFKANGNCGYVLKPQQM--CKGTFNPFSGDPLPANPKKQLILKVIS 722
N Q+ G M + F+ NG CGYVLKP + + +F+P P+ + L+++VIS
Sbjct: 578 NMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHP--EKPISPFKAQTLLIQVIS 635
Query: 723 GQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVH 782
GQQLPK + G I+DP V+V+I G+ +D + +T V++NGFNP W +TL F V
Sbjct: 636 GQQLPKVDKT---KEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVL 692
Query: 783 MPEIALVRFLVWDHDPIGR-DFVGQRTVTFSSLVPGYRHVYL-----EGLTEASIFVHIT 836
+PE+A++RF+V D+D R DF+GQ T+ ++ + GYRH++L L ASIFV+I
Sbjct: 693 VPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYIC 752
Query: 837 INE 839
I E
Sbjct: 753 IQE 755
>gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]
Length = 1095
Score = 335 bits (860), Expect = 2e-91
Identities = 195/496 (39%), Positives = 292/496 (58%), Gaps = 12/496 (2%)
Query: 1 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKS-EKAKILIDSIYKVTEGRQ 59
+S MQ+G ++ K++ ++ R F LD LRW PS+K EKAK+ I +I ++ G+
Sbjct: 112 ISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKN 171
Query: 60 SEIFHRQAEGN-FDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDE-DS 117
+E F + C F+I HG + ESLDL+ ++ + A W++GL+YL++ D
Sbjct: 172 TETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDF 231
Query: 118 LAKRQRT-HDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDE 176
+ Q T W+K FE AD +G+G++ + +L+ +LN L K+R F+E +
Sbjct: 232 MEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSK 291
Query: 177 NQGT--LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTD 234
+ T +T EEFC + + R ++Y LL+ S K++L +L FL+ EQ + ++T D
Sbjct: 292 EKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITED 351
Query: 235 YCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIAS 294
CLDII+++E+SEE + K L I+GFT ++ S CDIF+P +V QDM QPL +YYI +
Sbjct: 352 ICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINA 411
Query: 295 SHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDV 354
SHNTYL DQ + ++ Y R L+ GCR VE+D DG D EP++ + +T+ + FR V
Sbjct: 412 SHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSV 471
Query: 355 VETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSP 414
+E INK AFV +E+P+IL + NHCS+ QQ+ +AQ +K +FG+KL + E LPSP
Sbjct: 472 IEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSE-SYLPSP 530
Query: 415 QSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIR 474
+ LK I+VKGKKLP D EGEV+DED +E E + + Y NG +
Sbjct: 531 EKLKRMIIVKGKKLP--SDPDVLEGEVTDED--EEAEMSRRMSVDY-NGEQKQIRLCREL 585
Query: 475 KKLESLLKESQIRDKE 490
L S+ K Q RD E
Sbjct: 586 SDLVSICKSVQYRDFE 601
Score = 234 bits (597), Expect = 5e-61
Identities = 135/329 (41%), Positives = 190/329 (57%), Gaps = 19/329 (5%)
Query: 550 TDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN--- 606
TD++E+ + S +K ++LCRELSDLV SV +D + N
Sbjct: 556 TDEDEEAEMSRRMS----VDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWE 611
Query: 607 VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNY 666
+ SFSET A ++ + E F+ YN+K L+RIYPSA RIDSSN NP +WN GCQ+VA+N+
Sbjct: 612 MCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNF 671
Query: 667 QSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDP---LPANPKKQLILKVISG 723
Q+ G MM L+ F NG CGYVL+P M + + FS + LP L +K+ISG
Sbjct: 672 QTPGPMMDLHTGWFLQNGGCGYVLRPSIM-RDEVSYFSANTKGILPGVSPLALHIKIISG 730
Query: 724 QQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHM 783
Q PKP + +G++IDP+V +EI G+P DC + +T+ V N NP+++ET F V++
Sbjct: 731 QNFPKPKGAC--AKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNL 788
Query: 784 PEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIFVHITI- 837
PE+A++RF+V D D IG +F+GQ T+ F L PGYRHV L + ++FVHI I
Sbjct: 789 PELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAIT 848
Query: 838 NEIYGKNRQLQGLKGLFNKNPRHSSSENN 866
N G Q + L K R + N
Sbjct: 849 NRSGGGKAQKRSLSVRMGKKVREYTMLRN 877
>gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
Length = 997
Score = 335 bits (860), Expect = 2e-91
Identities = 195/496 (39%), Positives = 292/496 (58%), Gaps = 12/496 (2%)
Query: 1 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKS-EKAKILIDSIYKVTEGRQ 59
+S MQ+G ++ K++ ++ R F LD LRW PS+K EKAK+ I +I ++ G+
Sbjct: 14 ISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKN 73
Query: 60 SEIFHRQAEGN-FDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDE-DS 117
+E F + C F+I HG + ESLDL+ ++ + A W++GL+YL++ D
Sbjct: 74 TETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDF 133
Query: 118 LAKRQRT-HDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDE 176
+ Q T W+K FE AD +G+G++ + +L+ +LN L K+R F+E +
Sbjct: 134 MEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSK 193
Query: 177 NQGT--LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTD 234
+ T +T EEFC + + R ++Y LL+ S K++L +L FL+ EQ + ++T D
Sbjct: 194 EKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITED 253
Query: 235 YCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIAS 294
CLDII+++E+SEE + K L I+GFT ++ S CDIF+P +V QDM QPL +YYI +
Sbjct: 254 ICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINA 313
Query: 295 SHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDV 354
SHNTYL DQ + ++ Y R L+ GCR VE+D DG D EP++ + +T+ + FR V
Sbjct: 314 SHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSV 373
Query: 355 VETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSP 414
+E INK AFV +E+P+IL + NHCS+ QQ+ +AQ +K +FG+KL + E LPSP
Sbjct: 374 IEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSE-SYLPSP 432
Query: 415 QSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIR 474
+ LK I+VKGKKLP D EGEV+DED +E E + + Y NG +
Sbjct: 433 EKLKRMIIVKGKKLP--SDPDVLEGEVTDED--EEAEMSRRMSVDY-NGEQKQIRLCREL 487
Query: 475 KKLESLLKESQIRDKE 490
L S+ K Q RD E
Sbjct: 488 SDLVSICKSVQYRDFE 503
Score = 234 bits (597), Expect = 5e-61
Identities = 135/329 (41%), Positives = 190/329 (57%), Gaps = 19/329 (5%)
Query: 550 TDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN--- 606
TD++E+ + S +K ++LCRELSDLV SV +D + N
Sbjct: 458 TDEDEEAEMSRRMS----VDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWE 513
Query: 607 VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNY 666
+ SFSET A ++ + E F+ YN+K L+RIYPSA RIDSSN NP +WN GCQ+VA+N+
Sbjct: 514 MCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNF 573
Query: 667 QSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDP---LPANPKKQLILKVISG 723
Q+ G MM L+ F NG CGYVL+P M + + FS + LP L +K+ISG
Sbjct: 574 QTPGPMMDLHTGWFLQNGGCGYVLRPSIM-RDEVSYFSANTKGILPGVSPLALHIKIISG 632
Query: 724 QQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHM 783
Q PKP + +G++IDP+V +EI G+P DC + +T+ V N NP+++ET F V++
Sbjct: 633 QNFPKPKGAC--AKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNL 690
Query: 784 PEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIFVHITI- 837
PE+A++RF+V D D IG +F+GQ T+ F L PGYRHV L + ++FVHI I
Sbjct: 691 PELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAIT 750
Query: 838 NEIYGKNRQLQGLKGLFNKNPRHSSSENN 866
N G Q + L K R + N
Sbjct: 751 NRSGGGKAQKRSLSVRMGKKVREYTMLRN 779
>gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]
Length = 1194
Score = 330 bits (845), Expect = 9e-90
Identities = 247/785 (31%), Positives = 387/785 (49%), Gaps = 115/785 (14%)
Query: 90 LITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEI 149
++ NPE + W+ GL+ ++ ++++ W+K F N +G + + I
Sbjct: 114 MVAENPEVTKQWVEGLRSIIHNFR-ANNVSPMTCLKKHWMKLAFMT---NTNGKIPVRSI 169
Query: 150 HQLMHKLNVNLPRRKVRQMFQE-----ADTDENQGT-LTFEEFCVFYKMMSLRRDLYLLL 203
+ + + Q +E DE + T ++E+F + + R D+ L
Sbjct: 170 TRTFAS---GKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLF 226
Query: 204 LSYS-DKKDHLTVEELAQFLKVEQK---MNNVTTDY-----CLDIIKKFEVSEENKVKNV 254
+ DK D+LTV++L FL Q+ +N + + + II+ +E E+ K K +
Sbjct: 227 KKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGL 286
Query: 255 LGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMY 314
+ +GF ++ S E+YQ+MD PL +Y+I+SSHNTYLTG Q +S V+MY
Sbjct: 287 ISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMY 346
Query: 315 ARVLQEGCRCVEVDCWDGP--DGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVIL 372
+VL GCRCVE+DCWDG D EP++ HG + + ILF+DV++ I + AFV +E+PVIL
Sbjct: 347 RQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVIL 406
Query: 373 SIENHCSIQQQRKIAQYLKGIFGD---KLDLSSVDTGECKQLPSPQSLKGKILVKGKKLP 429
S ENHCS QQ K+++Y + +FGD K L S + LPSP LK KIL+K K+L
Sbjct: 407 SFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLK 466
Query: 430 YHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESLLKESQIRDK 489
E+E +K+LE+L + +
Sbjct: 467 ------------------PEVE----------------------KKQLEALRSMMEAGES 486
Query: 490 EDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSH--GRSLMTNFGKHKKTT-KSRSK 546
P + E N +S D +E G L + HK+ S K
Sbjct: 487 ASPANIL---------EDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKK 537
Query: 547 SYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDI---VDDGT 603
T ++E ++ K G T + LS ++ Y V Q +
Sbjct: 538 GLVTVEDEQAWMASYKYVGA---------TTNIHPYLSTMINYAQPVKFQGFHVAEERNI 588
Query: 604 TGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVA 663
N+ SF+E+ ++ + +F+ YN++Q++RIYP R+DSSN+ P +WNAGCQ+V+
Sbjct: 589 HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS 648
Query: 664 LNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFNPFSGDPLPANPKKQLILKVI 721
LNYQ+ MQLN+ KF+ NG+CGY+LKP M + TF+PFS P+ ++VI
Sbjct: 649 LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI 708
Query: 722 SGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ--TRVVDDNGFNPVW-EETLT 778
SGQ L + I +VEV++ GLP D + + TR+V +NG NPV+ EE+
Sbjct: 709 SGQFL----------SDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFV 758
Query: 779 F-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIF 832
F V +P++A++R V+D + +GQR + L GYRH+ L L+ +IF
Sbjct: 759 FRKVILPDLAVLRIAVYDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIF 815
Query: 833 VHITI 837
+I +
Sbjct: 816 CNIVL 820
>gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]
Length = 1175
Score = 330 bits (845), Expect = 9e-90
Identities = 247/785 (31%), Positives = 387/785 (49%), Gaps = 115/785 (14%)
Query: 90 LITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEI 149
++ NPE + W+ GL+ ++ ++++ W+K F N +G + + I
Sbjct: 114 MVAENPEVTKQWVEGLRSIIHNFR-ANNVSPMTCLKKHWMKLAFMT---NTNGKIPVRSI 169
Query: 150 HQLMHKLNVNLPRRKVRQMFQE-----ADTDENQGT-LTFEEFCVFYKMMSLRRDLYLLL 203
+ + + Q +E DE + T ++E+F + + R D+ L
Sbjct: 170 TRTFAS---GKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLF 226
Query: 204 LSYS-DKKDHLTVEELAQFLKVEQK---MNNVTTDY-----CLDIIKKFEVSEENKVKNV 254
+ DK D+LTV++L FL Q+ +N + + + II+ +E E+ K K +
Sbjct: 227 KKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGL 286
Query: 255 LGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMY 314
+ +GF ++ S E+YQ+MD PL +Y+I+SSHNTYLTG Q +S V+MY
Sbjct: 287 ISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMY 346
Query: 315 ARVLQEGCRCVEVDCWDGP--DGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVIL 372
+VL GCRCVE+DCWDG D EP++ HG + + ILF+DV++ I + AFV +E+PVIL
Sbjct: 347 RQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVIL 406
Query: 373 SIENHCSIQQQRKIAQYLKGIFGD---KLDLSSVDTGECKQLPSPQSLKGKILVKGKKLP 429
S ENHCS QQ K+++Y + +FGD K L S + LPSP LK KIL+K K+L
Sbjct: 407 SFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLK 466
Query: 430 YHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESLLKESQIRDK 489
E+E +K+LE+L + +
Sbjct: 467 ------------------PEVE----------------------KKQLEALRSMMEAGES 486
Query: 490 EDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSH--GRSLMTNFGKHKKTT-KSRSK 546
P + E N +S D +E G L + HK+ S K
Sbjct: 487 ASPANIL---------EDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKK 537
Query: 547 SYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDI---VDDGT 603
T ++E ++ K G T + LS ++ Y V Q +
Sbjct: 538 GLVTVEDEQAWMASYKYVGA---------TTNIHPYLSTMINYAQPVKFQGFHVAEERNI 588
Query: 604 TGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVA 663
N+ SF+E+ ++ + +F+ YN++Q++RIYP R+DSSN+ P +WNAGCQ+V+
Sbjct: 589 HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS 648
Query: 664 LNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFNPFSGDPLPANPKKQLILKVI 721
LNYQ+ MQLN+ KF+ NG+CGY+LKP M + TF+PFS P+ ++VI
Sbjct: 649 LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI 708
Query: 722 SGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ--TRVVDDNGFNPVW-EETLT 778
SGQ L + I +VEV++ GLP D + + TR+V +NG NPV+ EE+
Sbjct: 709 SGQFL----------SDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFV 758
Query: 779 F-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIF 832
F V +P++A++R V+D + +GQR + L GYRH+ L L+ +IF
Sbjct: 759 FRKVILPDLAVLRIAVYDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIF 815
Query: 833 VHITI 837
+I +
Sbjct: 816 CNIVL 820
>gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]
Length = 2302
Score = 307 bits (787), Expect = 5e-83
Identities = 222/667 (33%), Positives = 333/667 (49%), Gaps = 80/667 (11%)
Query: 217 ELAQFLKVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNF-MRSPACDIFNPL 275
+L FL V + + T D L II+KFE S + ++ EGF F M N
Sbjct: 1328 QLNDFL-VNCQGEHCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDE 1386
Query: 276 HHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDG 335
E +++ PL YYI SSHNTYLTG QL +S V++Y++VL +GCR VE+DCWDG DG
Sbjct: 1387 SQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDG 1446
Query: 336 EPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFG 395
P+++HG+TLT+KI F++VVE I++ AF+ ++ P+I+SIENHCS+ QQRK+A+ K +FG
Sbjct: 1447 MPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFG 1506
Query: 396 DKL---DLSSVDTGECKQLPSPQSLKGKILVKGKKLPYHL-------------------- 432
+KL L D + LPSP L+ K+L+K KKL H
Sbjct: 1507 EKLVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLASMQVQA 1566
Query: 433 --GDDAEEGEVSDEDSADEIEDE----------------------CKFKLHYSNGTTEHQ 468
G +A ++E+ DE EDE C KL + +
Sbjct: 1567 YNGGNANPRPANNEEEEDE-EDEYDYDYESLSDDNILEDRPENKSCNDKLQFE---YNEE 1622
Query: 469 VESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHE---GLNAHLKQSPDVKESGKKS 525
+ I+K S + ++ D E + F + K + + L+ + VK G +
Sbjct: 1623 IPKRIKKADNSACNKGKVYDMELGEEFYLDQNKKESRQIAPELSDLVIYCQAVKFPGLST 1682
Query: 526 HGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSD 585
S ++ GK +K+ KS + S K G+ G R + E S
Sbjct: 1683 LNAS-GSSRGKERKSRKSIFGNNPGRMSPGETASFNKTSGKSSCEGIR----QTWEESSS 1737
Query: 586 LVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRID 645
+ T S++A I+ ++ S +E A ++ ++ S++ + QL R YP+A RID
Sbjct: 1738 PLNPTTSLSA--IIRTPKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRID 1795
Query: 646 SSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT------ 699
SSN NPL +W G QLVALNYQ++ + LN A F+ANG CGYVLKP +
Sbjct: 1796 SSNPNPLMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQK 1855
Query: 700 FNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD 759
F+P D L + L ++SGQ + P +SM P +EV+++G+P+D C
Sbjct: 1856 FSPLERD-LDSMDPAVYSLTIVSGQNV-CPSNSMG-------SPCIEVDVLGMPLDSCHF 1906
Query: 760 QTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYR 819
+T+ + N NP+W E F VH ++ +RF V +++ QR + +L GYR
Sbjct: 1907 RTKPIHRNTLNPMWNEQFLFHVHFEDLVFLRFAVVENN--SSAVTAQRIIPLKALKRGYR 1964
Query: 820 HVYLEGL 826
H+ L L
Sbjct: 1965 HLQLRNL 1971
>gi|19115964 phospholipase C delta 3 [Homo sapiens]
Length = 789
Score = 295 bits (755), Expect = 2e-79
Identities = 171/463 (36%), Positives = 260/463 (56%), Gaps = 15/463 (3%)
Query: 4 MQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRW--RPSRKSEKAKILIDSIYKVTEGRQSE 61
M G+++ K++ T RL+ L E + + R R + + I V EG QSE
Sbjct: 65 MLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGHQSE 124
Query: 62 IFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKR 121
R G F P+ C TI ++LDL EEA+ W+ GL L A + D++++R
Sbjct: 125 GLRRFG-GAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARL---DAMSQR 180
Query: 122 QRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTL 181
+R D W+ AD N D ++ +EI L+ +NV++ +F+E D N L
Sbjct: 181 ERL-DHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNND-RL 238
Query: 182 TFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIK 241
E F + + R +L + YS + L+ EL +FL+ +Q T +I+
Sbjct: 239 EGAEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEEGATLARAQQLIQ 297
Query: 242 KFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLT 301
+E++E K ++ ++GF ++ SP + H V+QDM+QPL +Y+I+SSHNTYLT
Sbjct: 298 TYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLT 357
Query: 302 GDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKH 361
Q+ S + Y R +GCRCVE+DCW+GP GEPV++HG+TLTSKILFRDVV+ + H
Sbjct: 358 DSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDH 417
Query: 362 AFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKI 421
AF + +PVILS+ENHC ++QQ +A++L I GD L ++D+ ++LPSP+ LKG++
Sbjct: 418 AFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRV 477
Query: 422 LVKGKKLPYHLGDDA------EEGEVSDEDSADEIEDECKFKL 458
LVKGKKLP +D EE E DE+ +E+E + +L
Sbjct: 478 LVKGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRL 520
Score = 209 bits (532), Expect = 2e-53
Identities = 127/339 (37%), Positives = 192/339 (56%), Gaps = 31/339 (9%)
Query: 515 SPDVKESGKKSHGRSLMTNFGKHKKTTKSRSKS-YSTDDEEDTQQSTGKEGGQLYRLGRR 573
+P+ S ++ GR L+ K KK +RS+ + D E+ ++ +E ++ +R
Sbjct: 463 NPEELPSPEQLKGRVLV----KGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQR 518
Query: 574 RKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYN 630
R ++ ELS L VY ++ + + V S SE +A +++++ F+ +N
Sbjct: 519 RLAKQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHN 578
Query: 631 QKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVL 690
+QLTR+YP R++S+N++P WN+GCQLVALN+Q+ G M LN +F NG CGYVL
Sbjct: 579 ARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVL 638
Query: 691 KPQ--QMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPK----PPDSMFGDRGEIIDPF 744
KP + TF+P P P+ L ++V++ QQLPK P S I+DP
Sbjct: 639 KPACLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLNAEKPHS-------IVDPL 687
Query: 745 VEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIG-RDF 803
V +EI G+P DC + +T V +NGFNP W +TL F + PE+ALVRF+V D+D DF
Sbjct: 688 VRIEIHGVPADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDF 747
Query: 804 VGQRTVTFSSLVPGYRHVYL-----EGLTEASIFVHITI 837
VGQ T+ SSL GYRH++L L+ A++F+ I I
Sbjct: 748 VGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRI 786
>gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]
Length = 756
Score = 293 bits (750), Expect = 9e-79
Identities = 170/461 (36%), Positives = 260/461 (56%), Gaps = 16/461 (3%)
Query: 1 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK----SEKAKILIDSIYKVTE 56
+ + G+Q++K+K + R + L E + W+ SRK E I+ I +V
Sbjct: 19 LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 77
Query: 57 GRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDED 116
G ++E + A + CF+I + +LDLI +P +A+ W+ GL + I
Sbjct: 78 GHRTEGLEKFAR-DVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKI---IHHSG 133
Query: 117 SLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDE 176
S+ +RQ+ W+ +ADKN D ++ +E+ + +LN+ + R++F+E D +
Sbjct: 134 SMDQRQKLQ-HWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQ 192
Query: 177 NQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYC 236
+L EE FYKM++ R ++ + + L+V++L FL+ +Q+
Sbjct: 193 TD-SLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALA 251
Query: 237 LDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSH 296
L +I+++E SE K + + +GF ++ S F+ H VYQDM QPL +Y ++SSH
Sbjct: 252 LSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSH 311
Query: 297 NTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVE 356
NTYL DQL S + Y R L +GCRC+E+DCWDGP+ EP+++HGYT TSKILF DV+
Sbjct: 312 NTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLR 371
Query: 357 TINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQS 416
I +AF + +PVILS+ENHC+++QQR +A++L I G L +D G LPSP+
Sbjct: 372 AIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLD-GVTNSLPSPEQ 430
Query: 417 LKGKILVKGKKLPYHLGDDAEEGE----VSDEDSADEIEDE 453
LKGKIL+KGKKL L E G VSDED A E+EDE
Sbjct: 431 LKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDE 471
Score = 210 bits (534), Expect = 1e-53
Identities = 117/275 (42%), Positives = 171/275 (62%), Gaps = 16/275 (5%)
Query: 577 MKLCRELSDLVVYTNSVAAQDIVDDGTTGNVL----SFSETRAHQVVQQKSEQFMIYNQK 632
++L +ELSD+V+Y SV GT G SFSE RA +++Q+ F+ +N
Sbjct: 486 LRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVG 545
Query: 633 QLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKP 692
L+RIYP+ +R DSSN++P+ WN GCQ+VALN+Q+ G M + + +F+ NG CGYVLKP
Sbjct: 546 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKP 605
Query: 693 QQM--CKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEII 750
+ GTFNP + P +K+L ++VISGQQLPK + ++ I+DP V VEI
Sbjct: 606 AFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPK----VNKNKNSIVDPKVTVEIH 661
Query: 751 GLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGR-DFVGQRTV 809
G+ D QT V+ +NGFNP W+ F V +P++AL+RFLV D+D + DF+GQ T+
Sbjct: 662 GVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTI 721
Query: 810 TFSSLVPGYRHVYL-----EGLTEASIFVHITINE 839
+SL GYRHV+L + A++FV I++ +
Sbjct: 722 PLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD 756
>gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
Length = 777
Score = 293 bits (750), Expect = 9e-79
Identities = 170/461 (36%), Positives = 260/461 (56%), Gaps = 16/461 (3%)
Query: 1 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK----SEKAKILIDSIYKVTE 56
+ + G+Q++K+K + R + L E + W+ SRK E I+ I +V
Sbjct: 40 LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 98
Query: 57 GRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDED 116
G ++E + A + CF+I + +LDLI +P +A+ W+ GL + I
Sbjct: 99 GHRTEGLEKFAR-DVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKI---IHHSG 154
Query: 117 SLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDE 176
S+ +RQ+ W+ +ADKN D ++ +E+ + +LN+ + R++F+E D +
Sbjct: 155 SMDQRQKLQ-HWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQ 213
Query: 177 NQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYC 236
+L EE FYKM++ R ++ + + L+V++L FL+ +Q+
Sbjct: 214 TD-SLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALA 272
Query: 237 LDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSH 296
L +I+++E SE K + + +GF ++ S F+ H VYQDM QPL +Y ++SSH
Sbjct: 273 LSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSH 332
Query: 297 NTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVE 356
NTYL DQL S + Y R L +GCRC+E+DCWDGP+ EP+++HGYT TSKILF DV+
Sbjct: 333 NTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLR 392
Query: 357 TINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQS 416
I +AF + +PVILS+ENHC+++QQR +A++L I G L +D G LPSP+
Sbjct: 393 AIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLD-GVTNSLPSPEQ 451
Query: 417 LKGKILVKGKKLPYHLGDDAEEGE----VSDEDSADEIEDE 453
LKGKIL+KGKKL L E G VSDED A E+EDE
Sbjct: 452 LKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDE 492
Score = 210 bits (534), Expect = 1e-53
Identities = 117/275 (42%), Positives = 171/275 (62%), Gaps = 16/275 (5%)
Query: 577 MKLCRELSDLVVYTNSVAAQDIVDDGTTGNVL----SFSETRAHQVVQQKSEQFMIYNQK 632
++L +ELSD+V+Y SV GT G SFSE RA +++Q+ F+ +N
Sbjct: 507 LRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVG 566
Query: 633 QLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKP 692
L+RIYP+ +R DSSN++P+ WN GCQ+VALN+Q+ G M + + +F+ NG CGYVLKP
Sbjct: 567 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKP 626
Query: 693 QQM--CKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEII 750
+ GTFNP + P +K+L ++VISGQQLPK + ++ I+DP V VEI
Sbjct: 627 AFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPK----VNKNKNSIVDPKVTVEIH 682
Query: 751 GLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGR-DFVGQRTV 809
G+ D QT V+ +NGFNP W+ F V +P++AL+RFLV D+D + DF+GQ T+
Sbjct: 683 GVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTI 742
Query: 810 TFSSLVPGYRHVYL-----EGLTEASIFVHITINE 839
+SL GYRHV+L + A++FV I++ +
Sbjct: 743 PLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD 777
>gi|11386139 phospholipase C beta 3 [Homo sapiens]
Length = 1234
Score = 285 bits (730), Expect = 2e-76
Identities = 227/665 (34%), Positives = 328/665 (49%), Gaps = 71/665 (10%)
Query: 182 TFEEFCVFYKMMSLRRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQK---MNNVT----- 232
+ E F F + LR D+ +LL K K +LT+E+L F+ +Q+ +N V
Sbjct: 209 SLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLR 268
Query: 233 TDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYI 292
+I+K+E +++ ++ + +EGF+ ++ I ++ DM QPL Y+I
Sbjct: 269 PSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFI 328
Query: 293 ASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKIL 350
SSHNTYLT QL S V+MY + L GCRCVE+D W G P+ EP + HG+T+T+++
Sbjct: 329 NSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVP 388
Query: 351 FRDVVETINKHAFVKNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVD---TG 406
RDV+E I + AF + +PVILS ENH S +QQ K+A+Y + IFGD L + +D
Sbjct: 389 LRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLA 448
Query: 407 ECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTE 466
LPSPQ L G+ILVK KK DSA K L SN
Sbjct: 449 PGVPLPSPQDLMGRILVKNKK--------RHRPSAGGPDSAGR-----KRPLEQSNSALS 495
Query: 467 HQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSH 526
S E P S + L GL + P ++ +KS
Sbjct: 496 E----------SSAATEPSSPQLGSPSSDSCPGLSNGEEVGL-----EKPSLEP--QKSL 538
Query: 527 GRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDL 586
G + N G + R +DEE+ +Q+ K+ G + E+S L
Sbjct: 539 GDEGL-NRGPYVLGPADRED--EEEDEEEEEQTDPKK--PTTDEGTASSEVNATEEMSTL 593
Query: 587 VVYTNSVAAQDIV---DDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYR 643
V Y V + + SF ET+A + + + +F+ YN++QL+RIYP R
Sbjct: 594 VNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTR 653
Query: 644 IDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFN 701
+DSSN+ P +WN GCQLVALN+Q+ MQLN F+ NG GY+LKP+ M + +F+
Sbjct: 654 VDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFD 713
Query: 702 PFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDC-CKDQ 760
PF+ + L +KVISGQ L DR + +VEV++ GLPVD K +
Sbjct: 714 PFTEVIVDGIVANALRVKVISGQFL--------SDRK--VGIYVEVDMFGLPVDTRRKYR 763
Query: 761 TRVVDDNGFNPVW-EETLTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGY 818
TR N FNPVW EE F V +P +A +R ++ G FVG R + S++ GY
Sbjct: 764 TRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEE---GGKFVGHRILPVSAIRSGY 820
Query: 819 RHVYL 823
+V L
Sbjct: 821 HYVCL 825
>gi|25188201 phospholipase C, zeta 1 [Homo sapiens]
Length = 608
Score = 244 bits (623), Expect = 5e-64
Identities = 125/287 (43%), Positives = 187/287 (65%), Gaps = 2/287 (0%)
Query: 142 GLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYL 201
G +N+E+ +L+ KL++ V+Q+F++ D + QG +T EEF Y++++ R ++
Sbjct: 17 GKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLK-QGRITIEEFRAIYRIITHREEIIE 75
Query: 202 LLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFT 261
+ +YS+ + L LAQFL EQ ++ +II+K+E EE + + + +EGFT
Sbjct: 76 IFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFT 135
Query: 262 NFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEG 321
+M S C +F +VYQDM PL +Y+I+SSHNTYL DQLL S + Y L +G
Sbjct: 136 RYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKG 195
Query: 322 CRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQ 381
CRC+E+DCWDG EPVV+HGYTLTSK+LF+ V++ I+K+AF+ +++PV+LS+ENHCS
Sbjct: 196 CRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTA 255
Query: 382 QQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGKKL 428
QQ +A L+ FG+ L LS + LPSP++LK KILVK KK+
Sbjct: 256 QQEVMADNLQATFGESL-LSDMLDDFPDTLPSPEALKFKILVKNKKI 301
Score = 187 bits (475), Expect = 7e-47
Identities = 118/313 (37%), Positives = 169/313 (53%), Gaps = 29/313 (9%)
Query: 539 KTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTN-----SV 593
K T R S D +D + K G + ++ + +K+ LSDLV+YT S
Sbjct: 305 KETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSF 364
Query: 594 AAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLP 653
+ N S ET+A ++ + + +F+ + +K +TRIYP A R DSSNFNP
Sbjct: 365 QHSRLYQQFNENN--SIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQE 422
Query: 654 YWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQ--QMCKGTFNPFS---GDPL 708
+WN GCQ+VALN+Q+ G M L KF NG GY+LKP + K FNP + G P+
Sbjct: 423 FWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGMPI 482
Query: 709 PANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNG 768
L +++ISG QLP S ++G D V +E+ G+P D K QTRV+ N
Sbjct: 483 ------TLTIRLISGIQLPLTHSS--SNKG---DSLVIIEVFGVPNDQMKQQTRVIKKNA 531
Query: 769 FNPVWEETLTFTVHMPEIALVRFLVWDHDPI-GRDFVGQRTVTFSSLVPGYRHVYL---- 823
F+P W ET TF +H+PE+AL+RF+V I G +F+GQ T+ + GYR + L
Sbjct: 532 FSPRWNETFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRM 591
Query: 824 -EGLTEASIFVHI 835
E L AS+FV++
Sbjct: 592 GESLEPASLFVYV 604
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 238 bits (607), Expect = 4e-62
Identities = 158/473 (33%), Positives = 247/473 (52%), Gaps = 43/473 (9%)
Query: 22 RLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFHRQAEGNF---DPSCCFT 78
+ F + ++ W + I I I ++ G+ S F R E D S CF
Sbjct: 49 KTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFV 108
Query: 79 IYHGNH--MESLDLITSNPEEARTWITGLKYLMAGISDEDSL-AKRQRTHDQWVKQTFEE 135
I +G +++L L ++ +E WI GL +LM ED+L A ++W+++ F
Sbjct: 109 ILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLM-----EDTLQAPTPLQIERWLRKQFYS 163
Query: 136 ADKNGDGLLNIEEIHQLMHKLNVNLPR-RKVRQMFQEADTDENQGTLTFEEFCVFYK--M 192
D+N + ++ +++ ++ ++N +P R +R+ D ++ G +T+ +F Y+ M
Sbjct: 164 VDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERL--TDLEQRSGDITYGQFAQLYRSLM 221
Query: 193 MSLRRDLYLLLLSYSDKKD-------HLTVEELAQFLKVEQ---------KMNNVTTDYC 236
S ++ + L L S + +++ E QFL Q ++ +
Sbjct: 222 YSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFL 281
Query: 237 LDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQD-MDQPLCNYYIASS 295
D +++ E + ++ F F+ S ++N V D M+ PL +Y+I+SS
Sbjct: 282 RDPLREIE-------EPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSS 334
Query: 296 HNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVV 355
HNTYLTGDQ S+S ++ YAR L+ GCRC+E+DCWDGPDG PV++HG+TLT+KI F DV+
Sbjct: 335 HNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVL 394
Query: 356 ETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQ 415
TI +HAFV +E+PVILSIE+HCSI QQR +AQY K + GD L V+ LPSP
Sbjct: 395 HTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEI-SADGLPSPN 453
Query: 416 SLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQ 468
LK KIL+K KKL G EE S S ++I + K + Y H+
Sbjct: 454 QLKRKILIKHKKLAE--GSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHE 504
Score = 173 bits (439), Expect = 1e-42
Identities = 111/295 (37%), Positives = 159/295 (53%), Gaps = 20/295 (6%)
Query: 569 RLGRRRKTMKLCRELSDLVVYTNSVAAQDI---VDDGTTGNVLSFSETRAHQVVQQ-KSE 624
++ RRK K+ ELS+LVVY V + + ++ SF ET+A + V + K +
Sbjct: 941 KIMERRK--KIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGK 998
Query: 625 QFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANG 684
+F+ YN+ QL+RIYP R+DSSN++PLP W G QLVALN+Q+ + MQ+N+A F
Sbjct: 999 KFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGR 1058
Query: 685 NCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPF 744
+CGYVL+P M F+PF L + ++V+ + LPK RG I+ PF
Sbjct: 1059 HCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPK------NGRG-IVCPF 1111
Query: 745 VEVEIIGLPVDCCKDQTRVVDDNGFNPVW-EETLTFTVHMPEIALVRFLVWDHDPIG-RD 802
VE+E+ G D K +T V DNG NPVW + F + PE A +RF+V++ D ++
Sbjct: 1112 VEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQN 1171
Query: 803 FVGQRTVTFSSLVPGYRHV-----YLEGLTEASIFVHITINEIYGKNRQLQGLKG 852
F+ Q T L GYR V Y E L AS+ + I I +N L G
Sbjct: 1172 FLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKQENGDLSPFSG 1226
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 238 bits (607), Expect = 4e-62
Identities = 158/473 (33%), Positives = 247/473 (52%), Gaps = 43/473 (9%)
Query: 22 RLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFHRQAEGNF---DPSCCFT 78
+ F + ++ W + I I I ++ G+ S F R E D S CF
Sbjct: 49 KTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFV 108
Query: 79 IYHGNH--MESLDLITSNPEEARTWITGLKYLMAGISDEDSL-AKRQRTHDQWVKQTFEE 135
I +G +++L L ++ +E WI GL +LM ED+L A ++W+++ F
Sbjct: 109 ILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLM-----EDTLQAPTPLQIERWLRKQFYS 163
Query: 136 ADKNGDGLLNIEEIHQLMHKLNVNLPR-RKVRQMFQEADTDENQGTLTFEEFCVFYK--M 192
D+N + ++ +++ ++ ++N +P R +R+ D ++ G +T+ +F Y+ M
Sbjct: 164 VDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERL--TDLEQRSGDITYGQFAQLYRSLM 221
Query: 193 MSLRRDLYLLLLSYSDKKD-------HLTVEELAQFLKVEQ---------KMNNVTTDYC 236
S ++ + L L S + +++ E QFL Q ++ +
Sbjct: 222 YSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFL 281
Query: 237 LDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQD-MDQPLCNYYIASS 295
D +++ E + ++ F F+ S ++N V D M+ PL +Y+I+SS
Sbjct: 282 RDPLREIE-------EPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSS 334
Query: 296 HNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVV 355
HNTYLTGDQ S+S ++ YAR L+ GCRC+E+DCWDGPDG PV++HG+TLT+KI F DV+
Sbjct: 335 HNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVL 394
Query: 356 ETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQ 415
TI +HAFV +E+PVILSIE+HCSI QQR +AQY K + GD L V+ LPSP
Sbjct: 395 HTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEI-SADGLPSPN 453
Query: 416 SLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQ 468
LK KIL+K KKL G EE S S ++I + K + Y H+
Sbjct: 454 QLKRKILIKHKKLAE--GSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHE 504
Score = 172 bits (435), Expect = 3e-42
Identities = 108/280 (38%), Positives = 155/280 (55%), Gaps = 20/280 (7%)
Query: 569 RLGRRRKTMKLCRELSDLVVYTNSVAAQDI---VDDGTTGNVLSFSETRAHQVVQQ-KSE 624
++ RRK K+ ELS+LVVY V + + ++ SF ET+A + V + K +
Sbjct: 941 KIMERRK--KIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGK 998
Query: 625 QFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANG 684
+F+ YN+ QL+RIYP R+DSSN++PLP W G QLVALN+Q+ + MQ+N+A F
Sbjct: 999 KFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGR 1058
Query: 685 NCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPF 744
+CGYVL+P M F+PF L + ++V+ + LPK RG I+ PF
Sbjct: 1059 HCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPK------NGRG-IVCPF 1111
Query: 745 VEVEIIGLPVDCCKDQTRVVDDNGFNPVW-EETLTFTVHMPEIALVRFLVWDHDPIG-RD 802
VE+E+ G D K +T V DNG NPVW + F + PE A +RF+V++ D ++
Sbjct: 1112 VEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQN 1171
Query: 803 FVGQRTVTFSSLVPGYRHV-----YLEGLTEASIFVHITI 837
F+ Q T L GYR V Y E L AS+ + I I
Sbjct: 1172 FLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 235 bits (599), Expect = 3e-61
Identities = 150/443 (33%), Positives = 233/443 (52%), Gaps = 54/443 (12%)
Query: 38 SRKSEKAKILID--SIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNH--MESLDLITS 93
S+ ++K + +D I ++ G+ S+ F R CCFTI +G + +L L
Sbjct: 55 SKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAAD 114
Query: 94 NPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLM 153
+ E+A W++GLK L E A + W+++ D+ +++ E+ ++
Sbjct: 115 SKEDAVNWLSGLKIL----HQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTIL 170
Query: 154 HKLNVNLPRRK-VRQMFQEADTDENQGTLTFEEFCVFYKMM----------SLRRDLYLL 202
+N + K ++ F E +++ L+FE+F +FYK + ++D +
Sbjct: 171 PLINFKVSSAKFLKDKFVEIGAHKDE--LSFEQFHLFYKKLMFEQQKSILDEFKKDSSVF 228
Query: 203 LLSYSDKKD--------------HLTVEELAQFL-KVEQKMNNVTTDYCLDIIKKFEVSE 247
+L +D+ D H E AQ L KV ++M D + + F
Sbjct: 229 ILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPF---- 284
Query: 248 ENKVKNVLGIEGFTNFMRSPACDIFNPLHHEV-YQDMDQPLCNYYIASSHNTYLTGDQLL 306
L ++ F ++ S I++ + V QDM+ PL +Y+I+SSHNTYLTGDQL
Sbjct: 285 -------LFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLR 337
Query: 307 SQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKN 366
S+S + Y R L+ GCRC+E+DCWDGPDG+PV++HG+T T+KI F DVV+ I HAFV +
Sbjct: 338 SESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTS 397
Query: 367 EFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGK 426
FPVILSIE HCS++QQR +A+ K +FGD L L+ QLPSP L+ KI++K K
Sbjct: 398 SFPVILSIEEHCSVEQQRHMAKAFKEVFGDLL-LTKPTEASADQLPSPSQLREKIIIKHK 456
Query: 427 KLPYHLGDDAEEGEVSDEDSADE 449
KL + +V+ ED DE
Sbjct: 457 KL-----GPRGDVDVNMEDKKDE 474
Score = 171 bits (433), Expect = 5e-42
Identities = 105/295 (35%), Positives = 161/295 (54%), Gaps = 33/295 (11%)
Query: 575 KTMKLCRELSDLVVYTNSVA-AQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQ 633
K + ELSDLVVY + +D +++ + SF ET+A +++QK + YNQK
Sbjct: 922 KNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKG 981
Query: 634 LTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQ 693
LTR+YP R+DSSN++P W G Q+VALN+Q+ + MQ+N A F NG GYVL+P+
Sbjct: 982 LTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPE 1041
Query: 694 QMCKGTFNPFSGDPLPANPKKQLIL----KVISGQQLPKPPDSMFGDRGEIIDPFVEVEI 749
M + DP+P ++++++ KV+ + LPK S I PFVEVEI
Sbjct: 1042 SMRTEKY-----DPMPPESQRKILMTLTVKVLGARHLPKLGRS-------IACPFVEVEI 1089
Query: 750 IGLPVDCCKDQTRVVDDNGFNPVW---EETLTFTVHMPEIALVRFLVWDHDPIG-RDFVG 805
G D K +T VV+DNG +P+W +E +TF ++ P +A +RF+V++ D +F+
Sbjct: 1090 CGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLA 1149
Query: 806 QRTVTFSSLVPGYRHV-----YLEGLTEASIFVHITI-------NEIYGKNRQLQ 848
T ++ G+R V Y E + AS+ V + E+Y RQL+
Sbjct: 1150 HATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLR 1204
>gi|12083581 phosphoinositide-specific phospholipase C beta 1
isoform a [Homo sapiens]
Length = 1216
Score = 174 bits (441), Expect = 6e-43
Identities = 119/411 (28%), Positives = 212/411 (51%), Gaps = 35/411 (8%)
Query: 84 HMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEA--DKNGD 141
++ L+L+ E A+ W + L +L + + D ++++ + + +
Sbjct: 113 NISHLNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAYTKLKLQVTPE 166
Query: 142 GLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDEN------QGTLTFEEFCVFYKMMSL 195
G + ++ I++L + R++V + + Q T E + VF +
Sbjct: 167 GRIPLKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCP 221
Query: 196 RRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQK---MNNVT-----TDYCLDIIKKFEVS 246
R ++ + + K K +LTV+++ F+ ++Q+ +N + + +I+K+E +
Sbjct: 222 RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN 281
Query: 247 EENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLL 306
K + ++GF ++ + +P ++ +DM QPL +Y+I SSHNTYLT QL
Sbjct: 282 NSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA 341
Query: 307 SQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKILFRDVVETINKHAFV 364
S V+MY +VL GCRCVE+DCW G + EPV+ HG+T+T++I F++V+E I + AF
Sbjct: 342 GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK 401
Query: 365 KNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQ---LPSPQSLKGK 420
+ FP++LS ENH S +QQ K+A+Y + IFGD L + ++ + LPSP L K
Sbjct: 402 TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK 461
Query: 421 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVES 471
ILVK KK + + + + ++S++ S + F+ S G E ES
Sbjct: 462 ILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFE-PSSPGAGEADTES 511
Score = 145 bits (366), Expect = 3e-34
Identities = 99/309 (32%), Positives = 161/309 (52%), Gaps = 34/309 (11%)
Query: 545 SKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDD--- 601
++S DD++D ++S+ EG E+S+LV Y V +
Sbjct: 509 TESDDDDDDDDCKKSSMDEG-------TAGSEAMATEEMSNLVNYIQPVKFESFEISKKR 561
Query: 602 GTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQL 661
+ + SF ET+ + + + +F+ YN+ QL+RIYP R+DSSN+ P +WNAGCQ+
Sbjct: 562 NKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQM 621
Query: 662 VALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--FNPFSGDPLPANPKKQLILK 719
VALN+Q+ MQ+N ++ NG GY LKP+ M + F+PF+ + L +K
Sbjct: 622 VALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVK 681
Query: 720 VISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD--QTRVVDDNGFNPVW-EET 776
+ISGQ L + + +VEV++ GLPVD + +T+ N NPVW EE
Sbjct: 682 IISGQFL----------SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEP 731
Query: 777 LTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYL-----EGLTEAS 830
+ F V +P +A +R V++ G F+G R + ++ PGY ++ L + LT +
Sbjct: 732 IVFKKVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPA 788
Query: 831 IFVHITINE 839
+FV+I + +
Sbjct: 789 VFVYIEVKD 797
>gi|33356544 phosphoinositide-specific phospholipase C beta 1
isoform b [Homo sapiens]
Length = 1173
Score = 174 bits (441), Expect = 6e-43
Identities = 119/411 (28%), Positives = 212/411 (51%), Gaps = 35/411 (8%)
Query: 84 HMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEA--DKNGD 141
++ L+L+ E A+ W + L +L + + D ++++ + + +
Sbjct: 113 NISHLNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAYTKLKLQVTPE 166
Query: 142 GLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDEN------QGTLTFEEFCVFYKMMSL 195
G + ++ I++L + R++V + + Q T E + VF +
Sbjct: 167 GRIPLKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCP 221
Query: 196 RRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQK---MNNVT-----TDYCLDIIKKFEVS 246
R ++ + + K K +LTV+++ F+ ++Q+ +N + + +I+K+E +
Sbjct: 222 RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN 281
Query: 247 EENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLL 306
K + ++GF ++ + +P ++ +DM QPL +Y+I SSHNTYLT QL
Sbjct: 282 NSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA 341
Query: 307 SQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKILFRDVVETINKHAFV 364
S V+MY +VL GCRCVE+DCW G + EPV+ HG+T+T++I F++V+E I + AF
Sbjct: 342 GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK 401
Query: 365 KNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQ---LPSPQSLKGK 420
+ FP++LS ENH S +QQ K+A+Y + IFGD L + ++ + LPSP L K
Sbjct: 402 TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK 461
Query: 421 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVES 471
ILVK KK + + + + ++S++ S + F+ S G E ES
Sbjct: 462 ILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFE-PSSPGAGEADTES 511
Score = 145 bits (366), Expect = 3e-34
Identities = 99/309 (32%), Positives = 161/309 (52%), Gaps = 34/309 (11%)
Query: 545 SKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDD--- 601
++S DD++D ++S+ EG E+S+LV Y V +
Sbjct: 509 TESDDDDDDDDCKKSSMDEG-------TAGSEAMATEEMSNLVNYIQPVKFESFEISKKR 561
Query: 602 GTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQL 661
+ + SF ET+ + + + +F+ YN+ QL+RIYP R+DSSN+ P +WNAGCQ+
Sbjct: 562 NKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQM 621
Query: 662 VALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--FNPFSGDPLPANPKKQLILK 719
VALN+Q+ MQ+N ++ NG GY LKP+ M + F+PF+ + L +K
Sbjct: 622 VALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVK 681
Query: 720 VISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD--QTRVVDDNGFNPVW-EET 776
+ISGQ L + + +VEV++ GLPVD + +T+ N NPVW EE
Sbjct: 682 IISGQFL----------SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEP 731
Query: 777 LTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYL-----EGLTEAS 830
+ F V +P +A +R V++ G F+G R + ++ PGY ++ L + LT +
Sbjct: 732 IVFKKVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPA 788
Query: 831 IFVHITINE 839
+FV+I + +
Sbjct: 789 VFVYIEVKD 797
>gi|95147333 phospholipase C, beta 2 [Homo sapiens]
Length = 1185
Score = 169 bits (428), Expect = 2e-41
Identities = 100/253 (39%), Positives = 146/253 (57%), Gaps = 17/253 (6%)
Query: 192 MMSL--RRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQKMNNVTT--------DYCLDII 240
+MSL R ++ + SY K K ++T E L +F+ +Q+ + + + D +I
Sbjct: 212 LMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLI 271
Query: 241 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL 300
K+E S N + L EG F+ P + ++ DM QPL +Y+I SSHNTYL
Sbjct: 272 DKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYL 331
Query: 301 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKILFRDVVETI 358
T Q S +MY +VL GCRCVE+DCW G PD EP++ HG+T+T+ I F++ +E I
Sbjct: 332 TAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAI 391
Query: 359 NKHAFVKNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVDTGECK---QLPSP 414
+ AF + +P+ILS ENH S +QQ K+A+Y + IFGD L ++ K LPSP
Sbjct: 392 AESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSP 451
Query: 415 QSLKGKILVKGKK 427
+ L+GKIL+K KK
Sbjct: 452 EDLRGKILIKNKK 464
Score = 145 bits (366), Expect = 3e-34
Identities = 103/306 (33%), Positives = 163/306 (53%), Gaps = 31/306 (10%)
Query: 552 DEEDTQQSTGKEGGQLYRLGRRRKTMKL----CRELSDLVVY---TNSVAAQDIVDDGTT 604
+EE+ ++S + ++ ++ T L E+S LV Y T V+ + +
Sbjct: 511 EEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRS 570
Query: 605 GNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVAL 664
+ SF+E +A+ ++ + S QF+ YN++Q++RIYP R+DSSN+ P +WNAGCQ+VAL
Sbjct: 571 YVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVAL 630
Query: 665 NYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFNPFSGDPLPANPKKQLILKVIS 722
N+Q+ MQ N A F+ NG GY+LK + M + FNPFS D + L + VIS
Sbjct: 631 NFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVIS 690
Query: 723 GQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD-QTRV-VDDNGFNPVW-EETLTF 779
GQ L + + +VEVE+ GLP D + +T++ N NPVW EE F
Sbjct: 691 GQFLSE----------RSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVF 740
Query: 780 -TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIFV 833
+ MPE+A +R V + G F+G R + ++L GY H+ L LT ++F+
Sbjct: 741 EKILMPELASLRVAVMEE---GNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFI 797
Query: 834 HITINE 839
+ + +
Sbjct: 798 FLEMKD 803
>gi|209862851 plastin 3 [Homo sapiens]
Length = 630
Score = 45.1 bits (105), Expect = 6e-04
Identities = 26/81 (32%), Positives = 47/81 (58%), Gaps = 5/81 (6%)
Query: 116 DSLAKRQRTHDQW--VKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQE-- 171
D +A Q + D+ +K+ F + D N +G + E+H+L + N+ LP KVR++ Q+
Sbjct: 2 DEMATTQISKDELDELKEAFAKVDLNSNGFICDYELHELFKEANMPLPGYKVREIIQKLM 61
Query: 172 ADTDENQ-GTLTFEEFCVFYK 191
D D N+ G ++F+EF ++
Sbjct: 62 LDGDRNKDGKISFDEFVYIFQ 82
>gi|7549809 plastin 3 [Homo sapiens]
Length = 630
Score = 45.1 bits (105), Expect = 6e-04
Identities = 26/81 (32%), Positives = 47/81 (58%), Gaps = 5/81 (6%)
Query: 116 DSLAKRQRTHDQW--VKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQE-- 171
D +A Q + D+ +K+ F + D N +G + E+H+L + N+ LP KVR++ Q+
Sbjct: 2 DEMATTQISKDELDELKEAFAKVDLNSNGFICDYELHELFKEANMPLPGYKVREIIQKLM 61
Query: 172 ADTDENQ-GTLTFEEFCVFYK 191
D D N+ G ++F+EF ++
Sbjct: 62 LDGDRNKDGKISFDEFVYIFQ 82
>gi|11067753 calcium binding protein 5 [Homo sapiens]
Length = 173
Score = 44.7 bits (104), Expect = 8e-04
Identities = 27/69 (39%), Positives = 41/69 (59%), Gaps = 5/69 (7%)
Query: 127 QWVKQTFEEADKNGDGLLNIEEIHQLMHK-LNVNLPRRKVRQMFQEADTDENQGTLTFEE 185
Q ++ F+E D NGDG + + E+ Q M + L L R++ ++ +EAD + GT+ FEE
Sbjct: 108 QEMRDAFKEFDTNGDGEITLVELQQAMQRLLGERLTPREISEVVREADVN-GDGTVDFEE 166
Query: 186 FCVFYKMMS 194
F KMMS
Sbjct: 167 ---FVKMMS 172
>gi|223278387 calmodulin-like 5 [Homo sapiens]
Length = 146
Score = 44.3 bits (103), Expect = 0.001
Identities = 26/91 (28%), Positives = 46/91 (50%), Gaps = 3/91 (3%)
Query: 130 KQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVF 189
K+ F D +G+G +N +E+ + NL ++R++ E D+D G ++F+EF
Sbjct: 14 KKAFSAVDTDGNGTINAQELGAALKATGKNLSEAQLRKLISEVDSD-GDGEISFQEFLTA 72
Query: 190 YKMMSL-RRDLYLLLLSYSDKKD-HLTVEEL 218
K DL + ++ D H+TV+EL
Sbjct: 73 AKKARAGLEDLQVAFRAFDQDGDGHITVDEL 103
Score = 43.9 bits (102), Expect = 0.001
Identities = 22/68 (32%), Positives = 41/68 (60%), Gaps = 1/68 (1%)
Query: 119 AKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQ 178
AK+ R + ++ F D++GDG + ++E+ + M L LP+ ++ M +EAD D++
Sbjct: 73 AKKARAGLEDLQVAFRAFDQDGDGHITVDELRRAMAGLGQPLPQEELDAMIREADVDQD- 131
Query: 179 GTLTFEEF 186
G + +EEF
Sbjct: 132 GRVNYEEF 139
>gi|4885111 calmodulin-like 3 [Homo sapiens]
Length = 149
Score = 43.5 bits (101), Expect = 0.002
Identities = 39/148 (26%), Positives = 71/148 (47%), Gaps = 28/148 (18%)
Query: 53 KVTEGRQS-EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAG 111
+VTE +++ +F + +G C T G M SL NP EA L+ +M+
Sbjct: 9 QVTEFKEAFSLFDKDGDG-----CITTRELGTVMRSLG---QNPTEAE-----LRDMMSE 55
Query: 112 ISDEDS-----------LAKRQRTHD--QWVKQTFEEADKNGDGLLNIEEIHQLMHKLNV 158
I + + +A++ + D + +++ F DK+G+G ++ E+ +M +L
Sbjct: 56 IDRDGNGTVDFPEFLGMMARKMKDTDNEEEIREAFRVFDKDGNGFVSAAELRHVMTRLGE 115
Query: 159 NLPRRKVRQMFQEADTDENQGTLTFEEF 186
L +V +M + ADTD G + +EEF
Sbjct: 116 KLSDEEVDEMIRAADTD-GDGQVNYEEF 142
>gi|58218968 calmodulin 3 [Homo sapiens]
Length = 149
Score = 42.0 bits (97), Expect = 0.005
Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 1/57 (1%)
Query: 130 KQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEF 186
K+ F DK+GDG + +E+ +M L N +++ M E D D N GT+ F EF
Sbjct: 14 KEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN-GTIDFPEF 69
Score = 40.4 bits (93), Expect = 0.014
Identities = 19/61 (31%), Positives = 35/61 (57%), Gaps = 1/61 (1%)
Query: 126 DQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEE 185
++ +++ F DK+G+G ++ E+ +M L L +V +M +EAD D G + +EE
Sbjct: 83 EEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADID-GDGQVNYEE 141
Query: 186 F 186
F
Sbjct: 142 F 142
>gi|4502549 calmodulin 2 [Homo sapiens]
Length = 149
Score = 42.0 bits (97), Expect = 0.005
Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 1/57 (1%)
Query: 130 KQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEF 186
K+ F DK+GDG + +E+ +M L N +++ M E D D N GT+ F EF
Sbjct: 14 KEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN-GTIDFPEF 69
Score = 40.4 bits (93), Expect = 0.014
Identities = 19/61 (31%), Positives = 35/61 (57%), Gaps = 1/61 (1%)
Query: 126 DQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEE 185
++ +++ F DK+G+G ++ E+ +M L L +V +M +EAD D G + +EE
Sbjct: 83 EEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADID-GDGQVNYEE 141
Query: 186 F 186
F
Sbjct: 142 F 142
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,301,155
Number of Sequences: 37866
Number of extensions: 3098331
Number of successful extensions: 8963
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 46
Number of HSP's successfully gapped in prelim test: 155
Number of HSP's that attempted gapping in prelim test: 8544
Number of HSP's gapped (non-prelim): 492
length of query: 1655
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1539
effective length of database: 13,855,062
effective search space: 21322940418
effective search space used: 21322940418
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.