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Search of human proteins with 56676335
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56676335 RAP1 interacting factor 1 [Homo sapiens]
(2472 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56676335 RAP1 interacting factor 1 [Homo sapiens] 4828 0.0
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 78 9e-14
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 76 5e-13
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 76 5e-13
gi|87299628 biorientation of chromosomes in cell division 1-like... 74 1e-12
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 73 3e-12
gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo sa... 72 5e-12
gi|115334673 retinoblastoma-binding protein 1 isoform II [Homo s... 71 2e-11
gi|71061468 centromere protein E [Homo sapiens] 70 3e-11
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 69 7e-11
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 67 2e-10
gi|115334679 retinoblastoma-binding protein 1 isoform III [Homo ... 67 2e-10
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 64 1e-09
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 64 1e-09
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 63 4e-09
gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 61 2e-08
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 60 3e-08
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 59 5e-08
gi|109637791 transcription factor-like nuclear regulator [Homo s... 59 5e-08
gi|6631100 natural killer-tumor recognition sequence [Homo sapiens] 57 2e-07
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 57 2e-07
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 57 2e-07
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 56 4e-07
gi|38788260 bromodomain PHD finger transcription factor isoform ... 56 5e-07
gi|38788274 bromodomain PHD finger transcription factor isoform ... 56 5e-07
gi|21735569 claspin [Homo sapiens] 55 7e-07
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 55 1e-06
gi|224586823 coiled-coil domain containing 110 isoform b [Homo s... 54 1e-06
gi|239753245 PREDICTED: similar to UPF0634 protein C [Homo sapiens] 54 2e-06
gi|13540523 nucleosomal binding protein 1 [Homo sapiens] 54 2e-06
>gi|56676335 RAP1 interacting factor 1 [Homo sapiens]
Length = 2472
Score = 4828 bits (12523), Expect = 0.0
Identities = 2472/2472 (100%), Positives = 2472/2472 (100%)
Query: 1 MTARGQSPLAPLLETLEDPSASHGGQTDAYLTLTSRMTGEEGKEVITEIEKKLPRLYKVL 60
MTARGQSPLAPLLETLEDPSASHGGQTDAYLTLTSRMTGEEGKEVITEIEKKLPRLYKVL
Sbjct: 1 MTARGQSPLAPLLETLEDPSASHGGQTDAYLTLTSRMTGEEGKEVITEIEKKLPRLYKVL 60
Query: 61 KTHISSQNSELSSAALQALGFCLYNPKITSELSEANALELLSKLNDTIKNSDKNVRTRAL 120
KTHISSQNSELSSAALQALGFCLYNPKITSELSEANALELLSKLNDTIKNSDKNVRTRAL
Sbjct: 61 KTHISSQNSELSSAALQALGFCLYNPKITSELSEANALELLSKLNDTIKNSDKNVRTRAL 120
Query: 121 WVISKQTFPSEVVGKMVSSIIDSLEILFNKGETHSAVVDFEALNVIVRLIEQAPIQMGEE 180
WVISKQTFPSEVVGKMVSSIIDSLEILFNKGETHSAVVDFEALNVIVRLIEQAPIQMGEE
Sbjct: 121 WVISKQTFPSEVVGKMVSSIIDSLEILFNKGETHSAVVDFEALNVIVRLIEQAPIQMGEE 180
Query: 181 AVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIASITEQLMTTKLISELQKL 240
AVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIASITEQLMTTKLISELQKL
Sbjct: 181 AVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIASITEQLMTTKLISELQKL 240
Query: 241 FMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELGFRSGAPMIKKIAFIAWKSL 300
FMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELGFRSGAPMIKKIAFIAWKSL
Sbjct: 241 FMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELGFRSGAPMIKKIAFIAWKSL 300
Query: 301 IDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLALTKLEVWWYLLMRLGPHLPANFEQV 360
IDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLALTKLEVWWYLLMRLGPHLPANFEQV
Sbjct: 301 IDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLALTKLEVWWYLLMRLGPHLPANFEQV 360
Query: 361 CVPLIQSTISIDSNASPQGNSCHVATSPGLNPMTPVHKGASSPYGAPGTPRMNLSSNLGG 420
CVPLIQSTISIDSNASPQGNSCHVATSPGLNPMTPVHKGASSPYGAPGTPRMNLSSNLGG
Sbjct: 361 CVPLIQSTISIDSNASPQGNSCHVATSPGLNPMTPVHKGASSPYGAPGTPRMNLSSNLGG 420
Query: 421 MATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLSLEPLEHPLISSPSFFSKHANTLIT 480
MATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLSLEPLEHPLISSPSFFSKHANTLIT
Sbjct: 421 MATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLSLEPLEHPLISSPSFFSKHANTLIT 480
Query: 481 AVHDSFVAVGKDAPDVVVSAIWKELISLVKSVTESGNKKEKPGSEVLTLLLKSLESIVKS 540
AVHDSFVAVGKDAPDVVVSAIWKELISLVKSVTESGNKKEKPGSEVLTLLLKSLESIVKS
Sbjct: 481 AVHDSFVAVGKDAPDVVVSAIWKELISLVKSVTESGNKKEKPGSEVLTLLLKSLESIVKS 540
Query: 541 EVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANMDILNGTPALFLIQLIFNNFLECGVSD 600
EVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANMDILNGTPALFLIQLIFNNFLECGVSD
Sbjct: 541 EVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANMDILNGTPALFLIQLIFNNFLECGVSD 600
Query: 601 ERFFLSLESLVGCVLSGPTSPLAFSDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELI 660
ERFFLSLESLVGCVLSGPTSPLAFSDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELI
Sbjct: 601 ERFFLSLESLVGCVLSGPTSPLAFSDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELI 660
Query: 661 NQTNEVNQGDALEHNFSAIYGALTLPVNHIFSEQRFPVATMKTLLRTWSELYRAFARCAA 720
NQTNEVNQGDALEHNFSAIYGALTLPVNHIFSEQRFPVATMKTLLRTWSELYRAFARCAA
Sbjct: 661 NQTNEVNQGDALEHNFSAIYGALTLPVNHIFSEQRFPVATMKTLLRTWSELYRAFARCAA 720
Query: 721 LVATAEENLCCEELSSKIMSSLEDEGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKV 780
LVATAEENLCCEELSSKIMSSLEDEGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKV
Sbjct: 721 LVATAEENLCCEELSSKIMSSLEDEGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKV 780
Query: 781 KSPQRPSDWSKKKNEPLGKLTSLFKLIVKVIYSFHTLSFKEAHSDTLFTIGNSITGIISS 840
KSPQRPSDWSKKKNEPLGKLTSLFKLIVKVIYSFHTLSFKEAHSDTLFTIGNSITGIISS
Sbjct: 781 KSPQRPSDWSKKKNEPLGKLTSLFKLIVKVIYSFHTLSFKEAHSDTLFTIGNSITGIISS 840
Query: 841 VLGHISLPSMIRKIFATLTRPLALFYENSKLDEVPKVYSCLNNKLEKLLGEIIACLQFSY 900
VLGHISLPSMIRKIFATLTRPLALFYENSKLDEVPKVYSCLNNKLEKLLGEIIACLQFSY
Sbjct: 841 VLGHISLPSMIRKIFATLTRPLALFYENSKLDEVPKVYSCLNNKLEKLLGEIIACLQFSY 900
Query: 901 TGTYDSELLEQLSPLLCIIFLHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQ 960
TGTYDSELLEQLSPLLCIIFLHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQ
Sbjct: 901 TGTYDSELLEQLSPLLCIIFLHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQ 960
Query: 961 KFLLLLPGLETVEMMEESSGPYSDGTENSQLNVKISGMERKSNGKRDSFLAQTKNKKENM 1020
KFLLLLPGLETVEMMEESSGPYSDGTENSQLNVKISGMERKSNGKRDSFLAQTKNKKENM
Sbjct: 961 KFLLLLPGLETVEMMEESSGPYSDGTENSQLNVKISGMERKSNGKRDSFLAQTKNKKENM 1020
Query: 1021 KPAAKLKLESSSLKVKGEILLEEEKSTDFVFIPPEGKDAKERILTDHQKEVLKTKRCDIP 1080
KPAAKLKLESSSLKVKGEILLEEEKSTDFVFIPPEGKDAKERILTDHQKEVLKTKRCDIP
Sbjct: 1021 KPAAKLKLESSSLKVKGEILLEEEKSTDFVFIPPEGKDAKERILTDHQKEVLKTKRCDIP 1080
Query: 1081 AMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITEEQMDSDIVIPQDVTEDCG 1140
AMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITEEQMDSDIVIPQDVTEDCG
Sbjct: 1081 AMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITEEQMDSDIVIPQDVTEDCG 1140
Query: 1141 MAEHLEKSSLSNNECGSLDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSSS 1200
MAEHLEKSSLSNNECGSLDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSSS
Sbjct: 1141 MAEHLEKSSLSNNECGSLDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSSS 1200
Query: 1201 SVSNTTVAGTPPYPTSRRQTFITLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTD 1260
SVSNTTVAGTPPYPTSRRQTFITLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTD
Sbjct: 1201 SVSNTTVAGTPPYPTSRRQTFITLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTD 1260
Query: 1261 FLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEG 1320
FLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEG
Sbjct: 1261 FLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEG 1320
Query: 1321 IVVLENNPPGLLNQTECVSDNQVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVEI 1380
IVVLENNPPGLLNQTECVSDNQVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVEI
Sbjct: 1321 IVVLENNPPGLLNQTECVSDNQVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVEI 1380
Query: 1381 NLESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQK 1440
NLESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQK
Sbjct: 1381 NLESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQK 1440
Query: 1441 KERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETE 1500
KERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETE
Sbjct: 1441 KERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETE 1500
Query: 1501 QNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAK 1560
QNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAK
Sbjct: 1501 QNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAK 1560
Query: 1561 EEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICE 1620
EEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICE
Sbjct: 1561 EEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICE 1620
Query: 1621 KQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAI 1680
KQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAI
Sbjct: 1621 KQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAI 1680
Query: 1681 KRLHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQ 1740
KRLHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQ
Sbjct: 1681 KRLHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQ 1740
Query: 1741 PQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGL 1800
PQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGL
Sbjct: 1741 PQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGL 1800
Query: 1801 KEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFK 1860
KEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFK
Sbjct: 1801 KEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFK 1860
Query: 1861 TVGPCLGDSKNVSQESLETKEEKPEETPKMELSLENVTVEGNACKVTESNLEKAKTMELN 1920
TVGPCLGDSKNVSQESLETKEEKPEETPKMELSLENVTVEGNACKVTESNLEKAKTMELN
Sbjct: 1861 TVGPCLGDSKNVSQESLETKEEKPEETPKMELSLENVTVEGNACKVTESNLEKAKTMELN 1920
Query: 1921 VGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTT 1980
VGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTT
Sbjct: 1921 VGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTT 1980
Query: 1981 PVKLNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKMKNNEEMMIGEAMAETGHDGETE 2040
PVKLNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKMKNNEEMMIGEAMAETGHDGETE
Sbjct: 1981 PVKLNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKMKNNEEMMIGEAMAETGHDGETE 2040
Query: 2041 NEGITTKTSKPDEAETNMLTAEMDNFVCDTVEMSTEEGIIDANKTETNTEYSKSEEKLDN 2100
NEGITTKTSKPDEAETNMLTAEMDNFVCDTVEMSTEEGIIDANKTETNTEYSKSEEKLDN
Sbjct: 2041 NEGITTKTSKPDEAETNMLTAEMDNFVCDTVEMSTEEGIIDANKTETNTEYSKSEEKLDN 2100
Query: 2101 NQMVMESDILQEDHHTSQKVEEPSQCLASGTAISELIIEDNNASPQKLRELDPSLVSAND 2160
NQMVMESDILQEDHHTSQKVEEPSQCLASGTAISELIIEDNNASPQKLRELDPSLVSAND
Sbjct: 2101 NQMVMESDILQEDHHTSQKVEEPSQCLASGTAISELIIEDNNASPQKLRELDPSLVSAND 2160
Query: 2161 SPSGMQTRCVWSPLASPSTSILKRGLKRSQEDEISSPVNKVRRVSFADPIYQAGLADDID 2220
SPSGMQTRCVWSPLASPSTSILKRGLKRSQEDEISSPVNKVRRVSFADPIYQAGLADDID
Sbjct: 2161 SPSGMQTRCVWSPLASPSTSILKRGLKRSQEDEISSPVNKVRRVSFADPIYQAGLADDID 2220
Query: 2221 RRCSIVRSHSSNSSPIGKSVKTSPTTQSKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMA 2280
RRCSIVRSHSSNSSPIGKSVKTSPTTQSKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMA
Sbjct: 2221 RRCSIVRSHSSNSSPIGKSVKTSPTTQSKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMA 2280
Query: 2281 KESIPCPTESVYPPLVNCVAPVDIILPQITSNMWARGLGQLIRAKNIKTIGDLSTLTASE 2340
KESIPCPTESVYPPLVNCVAPVDIILPQITSNMWARGLGQLIRAKNIKTIGDLSTLTASE
Sbjct: 2281 KESIPCPTESVYPPLVNCVAPVDIILPQITSNMWARGLGQLIRAKNIKTIGDLSTLTASE 2340
Query: 2341 IKTLPIRSPKVSNVKKALRIYHEQQVKTRGLEEIPVFDISEKTVNGIENKSLSPDEERLV 2400
IKTLPIRSPKVSNVKKALRIYHEQQVKTRGLEEIPVFDISEKTVNGIENKSLSPDEERLV
Sbjct: 2341 IKTLPIRSPKVSNVKKALRIYHEQQVKTRGLEEIPVFDISEKTVNGIENKSLSPDEERLV 2400
Query: 2401 SDIIDPVALEIPLSKNLLAQISALALQLDSEDLHNYSGSQLFEMHEKLSCMANSVIKNLQ 2460
SDIIDPVALEIPLSKNLLAQISALALQLDSEDLHNYSGSQLFEMHEKLSCMANSVIKNLQ
Sbjct: 2401 SDIIDPVALEIPLSKNLLAQISALALQLDSEDLHNYSGSQLFEMHEKLSCMANSVIKNLQ 2460
Query: 2461 SRWRSPSHENSI 2472
SRWRSPSHENSI
Sbjct: 2461 SRWRSPSHENSI 2472
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 78.2 bits (191), Expect = 9e-14
Identities = 133/766 (17%), Positives = 276/766 (36%), Gaps = 59/766 (7%)
Query: 1491 GETSANAETEQNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIE 1550
G S AE + + +D N S G+G D +G++ +
Sbjct: 504 GSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKS---------------D 548
Query: 1551 NSESDSSEAKEEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEE 1610
+S+SDSS++ S + SN S D +++ D +S+
Sbjct: 549 SSDSDSSDSSNSSDSSDSSDSDSSDSNSSSD---------------SDSSDSDSSDSSDS 593
Query: 1611 DVSIKSPICEKQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVP 1670
D S S + D S++ DS+ +SD D + +++ ++ S ++
Sbjct: 594 DSSDSSNSSDSSDSSDS---SDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDS 650
Query: 1671 ESNLRTRNAIKRLHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSK 1730
N + ++ + DS D+ +SS S SS S + + S S
Sbjct: 651 SDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDS-------SNSSESSD 703
Query: 1731 GCDCCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDE 1790
D S S N+ ++D + S + + + S S S + S
Sbjct: 704 SSDSSDSDSSDSSDS----SNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSS 759
Query: 1791 HHSVNFHLGLKEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSLE 1850
S + D+ +DS S++ N+ S S N + DSS++
Sbjct: 760 DSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSS---NSSDSSNSSDSSDSSDSS 816
Query: 1851 SQESPNENFKTVGPCLGDSKNVSQESLETKEEKPEETPKMELSLENVTVEGNACKVTESN 1910
+S N + + DS N S S + ++ S + + + + + ++
Sbjct: 817 DSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNS 876
Query: 1911 LEKAKTMELNVGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEFN 1970
+ + + + N + +S + + + S ++ ++ + DS + ++ E + N
Sbjct: 877 SDSSDSSDSNESSNSS----DSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDN 932
Query: 1971 SDISLSDNTTPVKLNA-QTEISEQTAAGELDGGNDVSDLHSSEETNTKMKNNEEMMIGEA 2029
S+ S S N++ ++ + S+ + + + +D SD +SS+ +++ ++ +
Sbjct: 933 SNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSS 992
Query: 2030 MAETGHDGETENEGITTKTSKPDEAETNMLTAEMDNFVCDTVEMSTEEGIIDANKTETNT 2089
+ D ++ + S ++ + + D+ + S D++ + ++
Sbjct: 993 DSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1052
Query: 2090 EYSKSEEKLDNNQMVMESDILQEDHHTSQKVEEPSQCLASGTAISELIIEDNNASPQKLR 2149
+ S S + D++ SD D S E S S + D++ S
Sbjct: 1053 DSSNSSDSSDSSDSSDSSD--SSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSD 1110
Query: 2150 ELDPSLVSANDSPSGMQTRCVWSPLASPSTSILKRGLKRSQEDEISSPVNKVRRVSFADP 2209
D S S + + S S + S S S + SS + +D
Sbjct: 1111 SSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSS-----DSSDS 1165
Query: 2210 IYQAGLADDIDRRCSIVRSHSSNSSPIGKSVKTSPTTQSKHNTTSA 2255
+ +D D S S SS+SS S +S ++ S ++ S+
Sbjct: 1166 SDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1211
Score = 63.5 bits (153), Expect = 2e-09
Identities = 178/1038 (17%), Positives = 370/1038 (35%), Gaps = 132/1038 (12%)
Query: 1283 GTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEGIVVLENNPPGLLNQTECVSDNQ 1342
G + +++ K E G+K ++ +S +T + EG + N G + E +
Sbjct: 67 GRQENTQDGHKGEGNGSKWAEVGGKSFSTYSTLANEEGNIEGWNGDTG---KAETYGHDG 123
Query: 1343 VHLSESTMEHDNTKLKAATVENAVLLE---TNTVEEKNVEIN-----------LESKENT 1388
+H E + + + + + ++NA TN +KN + +E+
Sbjct: 124 IHGKEENITANGIQGQVSIIDNAGATNRSNTNGNTDKNTQNGDVGDAGHNEDVAVVQEDG 183
Query: 1389 PPVVISADQMVNEDSQVQ-----------ITPNQKTLRRSSRRRSEVVESTTESQDKENS 1437
P V S + NED ++ ITP Q +R+ + +EV T E +NS
Sbjct: 184 PQVAGSNNSTDNEDEIIENSCRNEGNTSEITP-QINSKRNGTKEAEVTPGTGEDAGLDNS 242
Query: 1438 HQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANA 1497
+E + S ++ + QE + H+ ++G+ S +
Sbjct: 243 DGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSK 302
Query: 1498 ETEQNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSS 1557
E + K DP N E DG DK+S+ SE +S+
Sbjct: 303 EYYDPEGKEDPHN---EVDG-----DKTSK------------------------SEENSA 330
Query: 1558 EAKEEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSP 1617
E+ ++ K ES ++++ I E+++H + ++ + IK P
Sbjct: 331 GIPEDNGSQRIEDTQKLNHRESKRVENR---------ITKESETHAVGKSQDKGIEIKGP 381
Query: 1618 ICEKQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTR 1677
+S + ++ E K + ++ + + + N++T+
Sbjct: 382 ------------------SSGNRNITKEVGKGNEGKEDKGQHG------MILGKGNVKTQ 417
Query: 1678 NAIKRLHK--RDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCC 1735
+ + + S +G S+ S+ F Q S G D
Sbjct: 418 GEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDA 477
Query: 1736 GEKSQPQEKSL--IGLKNTENNDV-EISETKKADVQAPVSPSETSQANPYSEGQFLDEHH 1792
+S S + E+ D S++K A+ S S+T+ ++ G ++ +
Sbjct: 478 NSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDN 537
Query: 1793 SVNFHLGLKEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQ 1852
+ K D+ + S + + S +++ +S S + + D DSS++ +S
Sbjct: 538 DKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDS-SDSDSSDSSDSDSS 596
Query: 1853 ESPNENFKTVGPCLGDSKNVSQESLETKEEKPEETPKMELSLENVTVEGNACKVTESNLE 1912
+S N + + DS + S S + E+ + ++ + + N+ ++++
Sbjct: 597 DSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNS-- 654
Query: 1913 KAKTMELNVGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEFNSD 1972
+ + + +S + S+ ++ ++ + DS + N+ E + +SD
Sbjct: 655 -----DSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSD 709
Query: 1973 ISLSDNTTPVKLN-AQTEISEQTAAGELDGGNDVSD----LHSSEETNTKMKNNEEMMIG 2027
SD++ N + ++ S + + + +D SD +SS+ +++ +N
Sbjct: 710 SDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSD 769
Query: 2028 EAMAETGHDGETENEGITTKTSKPDEAETNMLTAEMDNFVCDTVEMSTEE--GIIDANKT 2085
+ + D ++ + S +N + + D+ + S + D++ +
Sbjct: 770 SSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNS 829
Query: 2086 ETNTEYSKSEEKLDNNQMVMESDILQEDHHTSQKVEEPSQCLASGTAISELIIEDNNASP 2145
+++ S S + D++ SD + S + S S + D+N S
Sbjct: 830 SDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESS 889
Query: 2146 QKLRELDPSLVSANDSPSGMQTRCVWSPLASPSTSILKRGLKRSQEDEISSPVNKVRRVS 2205
D S S +DS + S + S S S ++ SS
Sbjct: 890 NSSDSSDSSNSSDSDSSDSSNS----SDSSDSSNSSDSSESSNSSDNSNSSD-------- 937
Query: 2206 FADPIYQAGLADDIDRRCSIVRSHSSNSSPIGKSVKTSPTTQSKHNTTSAKGFLSPGSRS 2265
+ +D D S S SSNSS S +S + S + +S S S S
Sbjct: 938 ------SSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDS 991
Query: 2266 PKFKSSKKCLISEMAKES 2283
S S + +S
Sbjct: 992 SDSSDSSDSSNSSDSSDS 1009
Score = 63.5 bits (153), Expect = 2e-09
Identities = 138/871 (15%), Positives = 303/871 (34%), Gaps = 111/871 (12%)
Query: 1146 EKSSLSNNECGSLDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSSSSVSNT 1205
+KS + S D S + SNS S S++ SS NS S SS S
Sbjct: 538 DKSDSGKGKSDSSDSDSSDSSNS----------SDSSDSSDSDSSDSNSSSDSDSSDS-- 585
Query: 1206 TVAGTPPYPTSRRQTFITLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTDFLPKA 1265
D S++ S +N S + ++ ++ +D +
Sbjct: 586 ----------------------DSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSD----S 619
Query: 1266 KQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEGIVVLE 1325
+ SKS+S+ + +K S + ++ + N S S ++ +S +
Sbjct: 620 SDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDS----- 674
Query: 1326 NNPPGLLNQTECVSDNQVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVEINLESK 1385
SD S S+ + N+ + + +++ E++ + + + +S
Sbjct: 675 -------------SD-----SSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSS 716
Query: 1386 ENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQKKERRK 1445
+++ +D + DS + + S S+ +++S D NS +
Sbjct: 717 DSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSD----SSDSSDSSNSSDSSDSSD 772
Query: 1446 EEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQNKKK 1505
+ + D + + + S+ + + ++S ++++ +
Sbjct: 773 SSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDS 832
Query: 1506 ADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSR 1565
+D N D + D S R + +S SS ++ SDSS++ +
Sbjct: 833 SDSSNSSDSSDSS----DSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNES 888
Query: 1566 KKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDES 1625
S + ++ D D + + + S ++ + S S + D S
Sbjct: 889 SNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSS 948
Query: 1626 NTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKRLHK 1685
++ DS+ +SD D + + +++S ++ S +S
Sbjct: 949 DSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSS------------------- 989
Query: 1686 RDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQEKS 1745
DS D+ +SS SD S S+ + + S S + S + S
Sbjct: 990 -DSSDSSDSSDSS--NSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSS 1046
Query: 1746 LIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGLKEDND 1805
+ +N + S++ + + S S S + S + S + D+
Sbjct: 1047 DSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSS 1106
Query: 1806 TINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTVGPC 1865
+DS S++ N+ S S + + DSS+ S ES +S + + +
Sbjct: 1107 DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSD--SSESSDSSDSSDSSDSSD 1164
Query: 1866 LGDSKNVSQESLETKEEKPEETPKMELSLENVTVEGNACKVTESNLEKAKTMELNVGNEA 1925
DS + S S + ++ S + + + + + + + + +++
Sbjct: 1165 SSDSSDSSDSSDSSNSSDSSDSSDSSDSSD-----------SSDSSDSSDSSDSSDSSDS 1213
Query: 1926 SFHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTTPVKLN 1985
S + S+ + E+ + DS + N+ + + +SD S SD+ N
Sbjct: 1214 SDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSD-STSDS------N 1266
Query: 1986 AQTEISEQTAAGELDGGNDVSDLHSSEETNT 2016
+++ ++ G +G + SD S+ ++
Sbjct: 1267 DESDSQSKSGNGNNNGSDSDSDSEGSDSNHS 1297
Score = 61.2 bits (147), Expect = 1e-08
Identities = 133/783 (16%), Positives = 282/783 (36%), Gaps = 54/783 (6%)
Query: 1115 DSKMMITEEQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNECGSLDKT-------SPEMSN 1167
DS + DS+ D ++ SS S+N S D + S + S+
Sbjct: 562 DSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSD 621
Query: 1168 SNNDERKKALISS---RKTSTECASSTENSFVVSSSSVSNTTVAGTPPYPTSRRQTFITL 1224
S +D K SS K+ + ++S+++S SS SN++ + + + +
Sbjct: 622 SKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSS 681
Query: 1225 EKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTDFLPKAKQREGTFSKSDSEKIVNGT 1284
+ + S++ S S ++ SS + ++ ++ +D + + SDS + +
Sbjct: 682 DSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDS----SDS 737
Query: 1285 KRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEGIVVLENNPPGLLNQTECVSDNQVH 1344
SS + ++ + + S S ++ +S + +++ N + SD+
Sbjct: 738 SNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSD- 796
Query: 1345 LSESTMEHDNTKLKAATVENAVLLETNTVEEKNVEINLESKENTPPVVISADQMVNEDSQ 1404
S ++ + N+ + + +++ +N+ + N + +S N+ S+D DS
Sbjct: 797 -SSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDS-SNSSDSSDSSDSSDGSDSD 854
Query: 1405 VQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQKKERRKEEEKPLQKSPLHIKDDVLP 1464
S+R S +++S D NS + E + D
Sbjct: 855 -----------SSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESS------NSSDSSDS 897
Query: 1465 KQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQNKKKADPENIKSEGDGTQDIVDK 1524
++ + N + + + E S+N+ N + + S+ + + D
Sbjct: 898 SNSSDSDSSDSSNSSDSSDSSNSSDSSE-SSNSSDNSNSSDSSNSSDSSDSSDSSNSSDS 956
Query: 1525 SSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWKNKSNESVDIQD 1584
S+ + +S SS + SDSS++ + S + S++S D D
Sbjct: 957 SNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSN--SSDSSDSSDSSD 1014
Query: 1585 QEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDESNTVICQDSTVTSDLLQVPD 1644
+ N S ++ D S S + D SN+ DS+ +SD D
Sbjct: 1015 SSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSD 1074
Query: 1645 DLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKRLHKRDSFDNCSLGESS-KIGIS 1703
+ +++S+ ++ S +S N+ DS D+ +SS S
Sbjct: 1075 S-----SDSSDSSESSDSSDSS-----------NSSDSSDSSDSSDSSDSSDSSDSSDSS 1118
Query: 1704 DISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQEKSLIGLKNTENNDVEISETK 1763
D S+ S+ + + S S + S + S + ++ + S++
Sbjct: 1119 DSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1178
Query: 1764 KADVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGLKEDNDTINDSLIVSETKSKENTM 1823
+ + S S S + S S + D+ +DS S++ ++
Sbjct: 1179 NSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSS 1238
Query: 1824 QESLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTVGPCLGDSKNVSQESLETKEEK 1883
S S N + DSS++ S + ES +++ G G + E ++
Sbjct: 1239 DSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHST 1298
Query: 1884 PEE 1886
++
Sbjct: 1299 SDD 1301
Score = 59.7 bits (143), Expect = 3e-08
Identities = 126/767 (16%), Positives = 266/767 (34%), Gaps = 50/767 (6%)
Query: 1123 EQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNECGSLDKTSPEMSNSNNDERKKALISSRK 1182
+ DSD + ++ ++ S S+++ S D S + S+S++ + + SS
Sbjct: 548 DSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDS 607
Query: 1183 TSTECASSTENSFVVSSSSVSNTTVAGTPPYPTSRRQTFITLEKFDGSENRPFSPSPLNN 1242
+ + +S + +S S S S+++ + + + + D S+N S S ++
Sbjct: 608 SDSSDSSDSSDS----SDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSS 663
Query: 1243 ISSTVTVKNNQETMIKTDFLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRS 1302
SS + ++ + + + S+S + + + S + + + N S
Sbjct: 664 NSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNS 723
Query: 1303 KPLMRSEPEKNTEESVEGIVVLENNPPGLLNQTECV-SDNQVHLSESTMEHDNTKLKAAT 1361
S +++ S ++ + ++ S N S+S+ D++ ++
Sbjct: 724 SDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS 783
Query: 1362 VENAVLLETNTVEEKNVEINLESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRR 1421
N +++ + + N N+ S+D ++ S + N SS
Sbjct: 784 DSN----DSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSS 839
Query: 1422 SEVVESTTESQDKENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEK 1481
+S+ S + S R + S + + +
Sbjct: 840 ----DSSDSSDSSDGSDSDSSNRSDSSNSSDSSD--------------SSDSSNSSDSSD 881
Query: 1482 GSNLHEKTLGETSANAETEQNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRA 1541
S+ +E + S+++ + +D N D + S + +
Sbjct: 882 SSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNS 941
Query: 1542 SQGLLSSIENSESDSSEAKEEGSRKKRSGKWKNKSNE---SVDIQDQEEKVVKQECIKAE 1598
S SS ++ SDSS + + + S + S++ S D D + + +
Sbjct: 942 SDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1001
Query: 1599 NQSHDYKATSEEDVSIKSPICEKQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSK 1658
N S ++ D S S D SN+ DS+ +SD D + +++S
Sbjct: 1002 NSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDS-----SDSSDSSN 1056
Query: 1659 YAEYSFTSLPVPESNLRTRNAIKRLHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLEC 1718
++ S +S S+ DS D+ ESS SD S+ S+ + +
Sbjct: 1057 SSDSSDSSDSSDSSD-----------SSDSSDSSDSSESS--DSSDSSNSSDSSDSSDSS 1103
Query: 1719 QHKRSRRVRRSKGCDCCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQ 1778
S S S + S + +N + S++ ++ + S S S
Sbjct: 1104 DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSS 1163
Query: 1779 ANPYSEGQFLDEHHSVNFHLGLKEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEI 1838
+ S S + D+ +DS S++ ++ S S + +
Sbjct: 1164 DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1223
Query: 1839 CDMDSSEAMSLESQESPNENFKTVGPCLGDSKNVSQESLETKEEKPE 1885
DSS+ S ES +S + + + DS + S S T + E
Sbjct: 1224 DSSDSSD--SNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDE 1268
Score = 34.3 bits (77), Expect = 1.6
Identities = 56/326 (17%), Positives = 132/326 (40%), Gaps = 17/326 (5%)
Query: 1114 EDSKMMITEEQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNECGSLDKTSPEMSNSNN--D 1171
E S DS + D + SS S+N S D S + S+S+N D
Sbjct: 925 ESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSD 984
Query: 1172 ERKKALISSRKTSTECASSTENSFVVSSSSVSNTTVAGTPPYPTSRRQTFITLEKFDGSE 1231
+ S S++ ++S+++S SS SN++ + ++ + + + D S+
Sbjct: 985 SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSD 1044
Query: 1232 NRPFSPSPLNNISSTVTVKNNQETMIKTDFLPKAKQREGTFSKSDSEKIVNGTKRSSRRA 1291
+ S S ++ S++ ++ ++ +D + + + S S+ + + SS +
Sbjct: 1045 SSDSSDS--SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDS--SNSSDSSDSS 1100
Query: 1292 GKAEQTGNKRSKPLMRSEPEKNTEESVEGIVVLENNPPGLLNQTECVSDNQVHLSESTME 1351
++ + + S S N+ +S + +++ + + SD+ SES+
Sbjct: 1101 DSSDSSDSSDSSDSSDSSDSSNSSDSSDS---SDSSDSSDSSNSSDSSDS----SESSDS 1153
Query: 1352 HDNTKLKAATVENAVLLETNTVEEKNVEINLESKENTPPVVISADQMVNEDSQVQITPNQ 1411
D++ ++ + +++ + N + +S +++ S+D + DS +
Sbjct: 1154 SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD----SSDSSDSSDSSDSSDSSD 1209
Query: 1412 KTLRRSSRRRSEVVESTTESQDKENS 1437
+ S S+ +S+ S E+S
Sbjct: 1210 SSDSSDSSDSSDSSDSSDSSDSNESS 1235
Score = 33.9 bits (76), Expect = 2.0
Identities = 69/456 (15%), Positives = 167/456 (36%), Gaps = 34/456 (7%)
Query: 1114 EDSKMMITEEQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNECGSLDKTSPEMS------- 1166
+ S + + DS+ + D + + S SN+ S S + S
Sbjct: 872 DSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSD 931
Query: 1167 NSNNDERKKALISSRKTSTECASSTENSFVVSSSSVSNTTVAGTPPYPTSRRQTFITLEK 1226
NSN+ + + SS + + +S + NS S+SS S+ + + ++ + + +
Sbjct: 932 NSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDS 991
Query: 1227 FDGSENRPFSPSPLNNISSTVTVKNNQETMIKTDFLPKAKQREGTFSKSDSEKIVNGTKR 1286
D S++ S S ++ SS + +N + + + SDS + +
Sbjct: 992 SDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSD-SSDSSD 1050
Query: 1287 SSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEGIVVLENNPPGLLNQTECVSDNQVHLS 1346
SS + ++ + + S S ++ +S E +++ + + SD+ S
Sbjct: 1051 SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSS-DSS 1109
Query: 1347 ESTMEHDNTKLKAATVENAVLLETNTVEEKNVEINLESKENTPPVVISADQMVNEDSQVQ 1406
+S+ D++ ++ + +++ + N + +S E++ S+D + DS
Sbjct: 1110 DSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSD----SSDSSDSSDSSDS 1165
Query: 1407 ITPNQKTLRRSSRRRSEVVESTTESQDKENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQ 1466
+ + S S+ +S+ S ++S + S
Sbjct: 1166 SDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS------------ 1213
Query: 1467 KLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQNKKKADPENIKSEGDGTQDIVDKSS 1526
++ + + + + ++S ++++ + +D + D T D D+S
Sbjct: 1214 ---SDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESD 1270
Query: 1527 EKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEE 1562
+ G + G S ++ SDS+ + +
Sbjct: 1271 SQSKSGNGN------NNGSDSDSDSEGSDSNHSTSD 1300
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 75.9 bits (185), Expect = 5e-13
Identities = 240/1223 (19%), Positives = 445/1223 (36%), Gaps = 235/1223 (19%)
Query: 1003 NGKRDSFLAQTKNKKENMKPAAKLKLESSSLKV-----KGEILLEEEKSTDFVFIPPEGK 1057
N FL Q + E + A KL+ + V K + LEE+ +++F + K
Sbjct: 329 NSSYVKFLKQATDNSE-ISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNK 387
Query: 1058 D--AKERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEP----MEIPT---- 1107
+ KE + D + E K ++ + P D+S+ Q + +PT
Sbjct: 388 EKNTKEHKVIDAKFET-KARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQR 446
Query: 1108 -----------LTRKPKEDSKMMITEEQMDSDIV-----IPQDVTEDCGMAEHLEKSSLS 1151
RK + + T E +D DIV +P+D+ E+ A ++ SS+
Sbjct: 447 TNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQ-SSVD 505
Query: 1152 NNECGS------LDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSSSSVSNT 1205
+ GS ++ +S +++ S+ D R K+ T + E ++ S+SN+
Sbjct: 506 HQGDGSSGTEQEVESSSVKLNISSKDNR-----GGIKSKTTAKVTKELYVKLTPVSLSNS 560
Query: 1206 TVAGT-----PPYPTSRRQTFIT--LEKFD-GSENRPFSPSPLNNISSTVTVKN-NQETM 1256
+ G P + + LEK G EN N +S + + +
Sbjct: 561 PIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPR 620
Query: 1257 IKTDFLPKAKQREGTFSKSDSE---------KIVNGTKRSSRRAGKAEQTGNKRSKPLMR 1307
+KT L + + S SD E K+ ++ +R N + L +
Sbjct: 621 VKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPK 680
Query: 1308 SEPEKNTEE---SVEGIVVLENNPPGLLNQTECVSDNQVHLSESTM--------EHDNTK 1356
S+ + ++ S E + +L+ + + N++H + T+ + D K
Sbjct: 681 SKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGK 740
Query: 1357 LKAATVENAVLLETNTVEEKNVEINLESKENTPPVVISADQMVNEDSQVQITPNQKTLRR 1416
K + + +T + I + K T + N DS+++ +
Sbjct: 741 RKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQ------SESSNYDSELEKEIKSMSKIG 794
Query: 1417 SSRRRSEVVESTTESQDKENS-HQKKERRKEEEKPLQKSPLHIKDDVLPKQKL----IAE 1471
++R + + +T + E+ H KK + K L+ S DD KQ+ AE
Sbjct: 795 AARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAE 854
Query: 1472 QTLQEN--LIEKGSNLHEKTLGETSAN--------------------AETEQNKKKADPE 1509
T+ ++ ++E L +K S + AET++ K +
Sbjct: 855 GTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTK 914
Query: 1510 NIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRS 1569
K DG DI +K +K S E SE D ++K+ KK+
Sbjct: 915 TCKKVQDGLSDIAEKFLKKD-----------------QSDETSEDDKKQSKKGTEEKKKP 957
Query: 1570 GKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICE-----KQDE 1624
+K +KV+K E Q ++ + E + + IC KQ +
Sbjct: 958 SDFK-------------KKVIKME------QQYESSSDGTEKLPEREEICHFPKGIKQIK 998
Query: 1625 SNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSF---TSLPVPESNLRTRNAIK 1681
+ T D S ++ ++K+E S YAE S S E A
Sbjct: 999 NGTT---DGEKKSKKIR-----DKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYG 1050
Query: 1682 RLHKRDSF--------DNCSLGESSKIGIS-DISSLSEKTFQTLECQHKRSRRVRRSKGC 1732
R KR +CS ++ K + D + S+K + +E + +R+ +R+
Sbjct: 1051 REKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKE 1110
Query: 1733 DCCGEKSQPQEKS----------------LIGLKNTENNDVEIS-ETKKADVQAPVSPS- 1774
G S E+S + +K + N + S + K+AD+ + S
Sbjct: 1111 IQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDI 1170
Query: 1775 ETSQANPYSEGQF-------LDEHHSVNFHLGLKEDN--DTINDSLIVSETKSKENTMQE 1825
E N EG + E+ ++ H G + + + ++ S+ V+ ++ E
Sbjct: 1171 EDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPE 1230
Query: 1826 SLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTVG------PCLGDSKN-VSQESLE 1878
+ + + E ++ S E S S + P E K G P ++KN V+ ES
Sbjct: 1231 NRIAKKMLLEEIKANLSSDEDGS--SDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDS 1288
Query: 1879 TKEEKPEETPKMELSLENVTVEG--------------------NACKVTESNLEKAKTME 1918
EE + + L +TV N KV+ + E + E
Sbjct: 1289 DSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQE 1348
Query: 1919 LNVGNEAS-FHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSD 1977
V E S ++R +T +++A +EEN+R+ + ++ +E ++ E N S +
Sbjct: 1349 SGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSE-NKSNSEEE 1407
Query: 1978 NTTPVKLNAQTEISEQTAAGELD-------GGNDVSDLHSSEETNTKMKN--NEEMMIGE 2028
+ + E E+ E D G + + ++ T+ +N EE +
Sbjct: 1408 EEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRK 1467
Query: 2029 AMAETGHDGETENEGITTKTSKP 2051
+AE + E E I + + P
Sbjct: 1468 RIAEREREREKLREVIEIEDASP 1490
Score = 61.2 bits (147), Expect = 1e-08
Identities = 117/627 (18%), Positives = 246/627 (39%), Gaps = 60/627 (9%)
Query: 994 KISGMERKSNGKRDSFLAQTKNKKENMKPAAKLKLESSSLKVKGEILLE---EEKSTDFV 1050
K+SG E+ +A+TK K +++K K++ + + L + +E S D
Sbjct: 885 KLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDK 944
Query: 1051 FIPPEGKDAKERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEPMEIPTLTR 1110
+G + K++ +D +K+V+K M + S D +EE P +
Sbjct: 945 KQSKKGTEEKKK-PSDFKKKVIK--------MEQQYESSSDGTEKLPEREEICHFPKGIK 995
Query: 1111 KPKEDSKMMITEEQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNEC-GSLDKTSPEMSNSN 1169
+ K + T+ + S + + + ++++ EKS+ + C S DK S +
Sbjct: 996 QIKNGT----TDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGR 1051
Query: 1170 NDERKKALISSRKTSTECASSTENSFVVSSSSVSNTTVAGTPPYPTSRRQTFI---TLEK 1226
+R K L S + +C+SS + + +++ RR T E
Sbjct: 1052 EKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEI 1111
Query: 1227 FDGSENRPFSPSPLNNISSTVTVKNNQETMI-----KTDFLPKAKQREGTFSKSDSEKIV 1281
GS + S +N + ++ +I + K+++ + S S I
Sbjct: 1112 QSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIE 1171
Query: 1282 NGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEGIVVLENNPPGLLNQTECVSDN 1341
+ + S EQ ++ L+ S + S G L + P ++ + +D
Sbjct: 1172 DDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSS--GDEALSKSVPVTVDDDDDDNDP 1229
Query: 1342 QVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVEINLESKENTPPVVISADQMVNE 1401
+ +++ + + +KA + + EE +++EN P A VN
Sbjct: 1230 ENRIAKKMLLEE---IKANLSSDEDGSSDDEPEEGKKRTGKQNEEN--PGDEEAKNQVNS 1284
Query: 1402 DSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQK-------KERRK-----EEEK 1449
+S ++K R R ++ S ES +++ + K + RRK E+
Sbjct: 1285 ESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDS 1344
Query: 1450 PLQKSPL-----HIKDDVLPKQKLIAEQTLQEN-------LIEKGSNLHEKTLGETSANA 1497
Q+S + +D+ P+ + + L+EN + + E + E +N+
Sbjct: 1345 DFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNS 1404
Query: 1498 ETEQNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSS 1557
E E+ +K+ + E + E + +D D S+ +GR + + L + +N+ +
Sbjct: 1405 EEEEEEKEEEEEEEEEEEEEEEDEND-DSKSPGKGRKKIRKILKDDKLRTETQNALKEEE 1463
Query: 1558 EAKEEGSRKKRSGKWKNKSNESVDIQD 1584
E ++ + ++R + K E ++I+D
Sbjct: 1464 ERRKRIAERERE---REKLREVIEIED 1487
Score = 56.6 bits (135), Expect = 3e-07
Identities = 199/1035 (19%), Positives = 364/1035 (35%), Gaps = 239/1035 (23%)
Query: 1276 DSEKIVNGTKRSSRRAGKAEQTGNKRSKPLMRSEPE---KNTEESVEGIVVL--ENNPPG 1330
DSE + +R K+ TG + K + EP+ NT E ++ +V + P
Sbjct: 432 DSEHMHQNVPTEEQRTNKS--TGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPED 489
Query: 1331 LLNQTECVSDNQVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVEINLESKENTPP 1390
+ E + Q S+++H E VE +V++N+ SK+N
Sbjct: 490 IFENLETAMEVQ-----SSVDHQGDGSSGTEQE---------VESSSVKLNISSKDNRGG 535
Query: 1391 VVISADQMVNEDSQVQITP----------------------------NQK---------- 1412
+ V ++ V++TP N K
Sbjct: 536 IKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQEN 595
Query: 1413 -------------TLRRSSRRRSEVVEST-----------TESQDKENSHQKKER----- 1443
L S RRS V++T T + D+E + KE+
Sbjct: 596 SDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSV 655
Query: 1444 --RKEEEKPLQKSPL-HIKDDVLPKQKLIAEQTLQEN--------LIEKGSNLHEKTLGE 1492
RK++++ S + + K + LPK K +T+ +N ++++ S + + +
Sbjct: 656 PVRKKDKRNSSDSAIDNPKPNKLPKSK--QSETVDQNSDSDEMLAILKEVSRMSHSSSSD 713
Query: 1493 TSAN-----------AETEQNKKKADPENIKSEGDGT--QDIVDKSSEKLVRGRTRYQTR 1539
T N +T+ K KS G+ KS++ + + + QT+
Sbjct: 714 TDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQ 773
Query: 1540 RASQGLLSSIENSESDSSEAKEEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAEN 1599
S S +E S+ + KKR K+ + ++EK K+ +N
Sbjct: 774 SESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDS------SEDEKHSKK---GMDN 824
Query: 1600 QSHDYKATSEEDVSIKSPICEKQDESNTVICQDSTVTSD--LLQVPDDLPNVCEEKNETS 1657
Q H TS+E S E++ E T + TV D ++++ D LP + T
Sbjct: 825 QGHKNLKTSQEG---SSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTD 881
Query: 1658 -----KYAEYSFTSLPV--------PESNLRTRNAIK----------RLHKRDSFDNCSL 1694
E SFTSL V +L+T+ K + K+D D S
Sbjct: 882 GVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSE 941
Query: 1695 GE--SSKIGISDISSLSE--KTFQTLECQHKRS-----------------RRVRRSKGCD 1733
+ SK G + S+ K +E Q++ S + +++ K
Sbjct: 942 DDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGT 1001
Query: 1734 CCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHS 1793
GEK + + K E +D T K D ++S+ G + E
Sbjct: 1002 TDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGD------SCDSSEDKKSKNGAYGRE--- 1052
Query: 1794 VNFHLGLKEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQE 1853
K+ + S + S +T + S+ +E+ C+ +E +E
Sbjct: 1053 -------KKRCKLLGKSSRKRQDCSSSDTEKYSM-------KEDGCNSSDKRLKRIELRE 1098
Query: 1854 SPNENFK--TVGPCLGDSKNVSQESLETKEEKPEET----------PKMELSLENVTVEG 1901
N + K T G S + ++ES E ++K + T K SL T
Sbjct: 1099 RRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRK 1158
Query: 1902 NACKVTESNLEKAKTMELNVGNEASFHGQE----------RTKTGISEEAAIEENKR--- 1948
A +T S+ + + N E S Q+ + TG + + E +
Sbjct: 1159 QA-DITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVP 1217
Query: 1949 ----NDDSEADTAKLNAKEVATEEFNSDISL----SDNTTPVKLNAQTEISEQTAAGELD 2000
+DD + D AK++ EE +++S S + P + +T + G+ +
Sbjct: 1218 VTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEE 1277
Query: 2001 GGNDV-SDLHSSEETNTKMKNNEEMMIGEAMAETGHDGE------TENEGITTKTSKPDE 2053
N V S+ S E + K + ++ + G GE E++ + + +
Sbjct: 1278 AKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVS 1337
Query: 2054 AETNMLTAEMDNFVCDTVEMSTEE---GIIDANKTETNTEYSKSEEKLDNNQMVMESDIL 2110
+E + + ++ V + V S +E A K E ++K ++ ++ D
Sbjct: 1338 SEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSS 1397
Query: 2111 QEDHHTSQKVEEPSQ 2125
E+ S++ EE +
Sbjct: 1398 SENKSNSEEEEEEKE 1412
Score = 49.3 bits (116), Expect = 5e-05
Identities = 115/575 (20%), Positives = 221/575 (38%), Gaps = 70/575 (12%)
Query: 975 MEESSGPYSDGTENSQLNVKI----SGMERKSNGKRDSFLAQTKNKKENMKPAAKLKLES 1030
ME+ SDGTE +I G+++ NG D K + + K +L +
Sbjct: 967 MEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYA 1026
Query: 1031 SSLKVKGEIL--LEEEKSTDFVFIPPE------GKDAKER---ILTDHQKEVLKTKRCDI 1079
KG+ E++KS + + + GK +++R +D +K +K C+
Sbjct: 1027 EKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCN- 1085
Query: 1080 PAMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITEEQMDSDIVIPQDVTEDC 1139
S ++ ++ L + SK E Q S ++ +ED
Sbjct: 1086 ------------------SSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSED- 1126
Query: 1140 GMAEHLEKSSLSNNECGSLDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSS 1199
+K S+ + + K S + +RK+A I+S +S++ +NS S
Sbjct: 1127 ---NKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITS-SSSSDIEDDDQNSIGEGS 1182
Query: 1200 SSVSNTTVAGTPPYPTSRRQTFITLEKF-DGSENRPFSPSPLNNISSTVTVKNNQETMIK 1258
S P + + F S + S S + + + + K
Sbjct: 1183 SDEQKIK-------PVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAK 1235
Query: 1259 TDFLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKA--EQTGNKRSKPLMRSEPEKNTEE 1316
L + K + S+ + + +R GK E G++ +K + SE + ++EE
Sbjct: 1236 KMLLEEIKANLSSDEDGSSD---DEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEE 1292
Query: 1317 SVEGIVVLENNPPGLLNQTECVSDNQVHLSESTM--EHDNTKLKAATVENAVLLETNTVE 1374
S + LL VSD + + T EH K + ++ E + +
Sbjct: 1293 SKK-----PRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQ 1347
Query: 1375 EKNVEINL-ESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQD 1433
E V + ES++ P SA + ++ NQ++ ++ +RR V+ + S++
Sbjct: 1348 ESGVSEEVSESEDEQRPRTRSA-------KKAELEENQRSYKQKKKRRRIKVQEDSSSEN 1400
Query: 1434 KENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGET 1493
K NS +++E ++EEE+ ++ ++D K + + I K L +T +
Sbjct: 1401 KSNSEEEEEEKEEEEEE-EEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTET--QN 1457
Query: 1494 SANAETEQNKKKADPENIKSEGDGTQDIVDKSSEK 1528
+ E E+ K+ A+ E + + +I D S K
Sbjct: 1458 ALKEEEERRKRIAEREREREKLREVIEIEDASPTK 1492
Score = 38.1 bits (87), Expect = 0.11
Identities = 105/504 (20%), Positives = 183/504 (36%), Gaps = 82/504 (16%)
Query: 1797 HLGLKED-------NDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSL 1849
HL L+ED D +N E K + + G E D+ SEA
Sbjct: 368 HLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLS 427
Query: 1850 ESQ---ESPNENFKTVGPCLGDSKNVSQESLETKEE---KPEETPKMELSLENVTVEGNA 1903
Q E ++N T S + + KEE +P T + +L ++ V+V +
Sbjct: 428 RKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSE-DLDMDIVSVPSSV 486
Query: 1904 CKVTESNLEKAKTMELNVGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAKE 1963
+ NLE A ++ +V ++ G T+ + E ++++ N + D+ +
Sbjct: 487 PEDIFENLETAMEVQSSVDHQGD--GSSGTEQEV-ESSSVKLNISSKDNRGGIKSKTTAK 543
Query: 1964 VATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKMKNNEE 2023
V E + +S + +P+K E+ + D + S N K+ E+
Sbjct: 544 VTKELYVKLTPVSLSNSPIKGADCQEVPQD------------KDGYKSCGLNPKL---EK 588
Query: 2024 MMIGEAMAETGHDGETENEGITTKTSKPDEAETNMLTAEMDNFVCDTVEMSTEEGIIDAN 2083
+G+ ++NE + E E ++L E D V+ +
Sbjct: 589 CGLGQE--------NSDNEHLV-------ENEVSLLLEESDLRRSPRVKTTPLR-----R 628
Query: 2084 KTETNTEYSKSEEKLDNNQMVMESDILQEDHHTSQKVEEPSQCLASGTAISELIIEDNNA 2143
TETN S S+E+ + + ++E S V + + +S +AI +N
Sbjct: 629 PTETNPVTSNSDEECN--------ETVKEKQKLSVPVRKKDKRNSSDSAI-------DNP 673
Query: 2144 SPQKLRELDPSLVSANDSPSGMQTRCVWSPLASPSTSILKRGLKRSQEDEISSPVNKVR- 2202
P KL + S +S S +ILK + S + +N++
Sbjct: 674 KPNKLPKSKQSETVDQNSDS------------DEMLAILKEVSRMSHSSSSDTDINEIHT 721
Query: 2203 -RVSFADPIYQAGLADDIDRRCSIVRSHSSNSSPIGKSVKTSPTTQSKHNTTSAKGFLSP 2261
+ D QAG D R+ S S + GKS K+S ++ K T S
Sbjct: 722 NHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYD- 780
Query: 2262 GSRSPKFKSSKKCLISEMAKESIP 2285
+ KS K + K+ IP
Sbjct: 781 SELEKEIKSMSKIGAARTTKKRIP 804
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 75.9 bits (185), Expect = 5e-13
Identities = 240/1223 (19%), Positives = 445/1223 (36%), Gaps = 235/1223 (19%)
Query: 1003 NGKRDSFLAQTKNKKENMKPAAKLKLESSSLKV-----KGEILLEEEKSTDFVFIPPEGK 1057
N FL Q + E + A KL+ + V K + LEE+ +++F + K
Sbjct: 367 NSSYVKFLKQATDNSE-ISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNK 425
Query: 1058 D--AKERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEP----MEIPT---- 1107
+ KE + D + E K ++ + P D+S+ Q + +PT
Sbjct: 426 EKNTKEHKVIDAKFET-KARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQR 484
Query: 1108 -----------LTRKPKEDSKMMITEEQMDSDIV-----IPQDVTEDCGMAEHLEKSSLS 1151
RK + + T E +D DIV +P+D+ E+ A ++ SS+
Sbjct: 485 TNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQ-SSVD 543
Query: 1152 NNECGS------LDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSSSSVSNT 1205
+ GS ++ +S +++ S+ D R K+ T + E ++ S+SN+
Sbjct: 544 HQGDGSSGTEQEVESSSVKLNISSKDNR-----GGIKSKTTAKVTKELYVKLTPVSLSNS 598
Query: 1206 TVAGT-----PPYPTSRRQTFIT--LEKFD-GSENRPFSPSPLNNISSTVTVKN-NQETM 1256
+ G P + + LEK G EN N +S + + +
Sbjct: 599 PIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPR 658
Query: 1257 IKTDFLPKAKQREGTFSKSDSE---------KIVNGTKRSSRRAGKAEQTGNKRSKPLMR 1307
+KT L + + S SD E K+ ++ +R N + L +
Sbjct: 659 VKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPK 718
Query: 1308 SEPEKNTEE---SVEGIVVLENNPPGLLNQTECVSDNQVHLSESTM--------EHDNTK 1356
S+ + ++ S E + +L+ + + N++H + T+ + D K
Sbjct: 719 SKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGK 778
Query: 1357 LKAATVENAVLLETNTVEEKNVEINLESKENTPPVVISADQMVNEDSQVQITPNQKTLRR 1416
K + + +T + I + K T + N DS+++ +
Sbjct: 779 RKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQ------SESSNYDSELEKEIKSMSKIG 832
Query: 1417 SSRRRSEVVESTTESQDKENS-HQKKERRKEEEKPLQKSPLHIKDDVLPKQKL----IAE 1471
++R + + +T + E+ H KK + K L+ S DD KQ+ AE
Sbjct: 833 AARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAE 892
Query: 1472 QTLQEN--LIEKGSNLHEKTLGETSAN--------------------AETEQNKKKADPE 1509
T+ ++ ++E L +K S + AET++ K +
Sbjct: 893 GTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTK 952
Query: 1510 NIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRS 1569
K DG DI +K +K S E SE D ++K+ KK+
Sbjct: 953 TCKKVQDGLSDIAEKFLKKD-----------------QSDETSEDDKKQSKKGTEEKKKP 995
Query: 1570 GKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICE-----KQDE 1624
+K +KV+K E Q ++ + E + + IC KQ +
Sbjct: 996 SDFK-------------KKVIKME------QQYESSSDGTEKLPEREEICHFPKGIKQIK 1036
Query: 1625 SNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSF---TSLPVPESNLRTRNAIK 1681
+ T D S ++ ++K+E S YAE S S E A
Sbjct: 1037 NGTT---DGEKKSKKIR-----DKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYG 1088
Query: 1682 RLHKRDSF--------DNCSLGESSKIGIS-DISSLSEKTFQTLECQHKRSRRVRRSKGC 1732
R KR +CS ++ K + D + S+K + +E + +R+ +R+
Sbjct: 1089 REKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKE 1148
Query: 1733 DCCGEKSQPQEKS----------------LIGLKNTENNDVEIS-ETKKADVQAPVSPS- 1774
G S E+S + +K + N + S + K+AD+ + S
Sbjct: 1149 IQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDI 1208
Query: 1775 ETSQANPYSEGQF-------LDEHHSVNFHLGLKEDN--DTINDSLIVSETKSKENTMQE 1825
E N EG + E+ ++ H G + + + ++ S+ V+ ++ E
Sbjct: 1209 EDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPE 1268
Query: 1826 SLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTVG------PCLGDSKN-VSQESLE 1878
+ + + E ++ S E S S + P E K G P ++KN V+ ES
Sbjct: 1269 NRIAKKMLLEEIKANLSSDEDGS--SDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDS 1326
Query: 1879 TKEEKPEETPKMELSLENVTVEG--------------------NACKVTESNLEKAKTME 1918
EE + + L +TV N KV+ + E + E
Sbjct: 1327 DSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQE 1386
Query: 1919 LNVGNEAS-FHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSD 1977
V E S ++R +T +++A +EEN+R+ + ++ +E ++ E N S +
Sbjct: 1387 SGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSE-NKSNSEEE 1445
Query: 1978 NTTPVKLNAQTEISEQTAAGELD-------GGNDVSDLHSSEETNTKMKN--NEEMMIGE 2028
+ + E E+ E D G + + ++ T+ +N EE +
Sbjct: 1446 EEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRK 1505
Query: 2029 AMAETGHDGETENEGITTKTSKP 2051
+AE + E E I + + P
Sbjct: 1506 RIAEREREREKLREVIEIEDASP 1528
Score = 61.2 bits (147), Expect = 1e-08
Identities = 117/627 (18%), Positives = 246/627 (39%), Gaps = 60/627 (9%)
Query: 994 KISGMERKSNGKRDSFLAQTKNKKENMKPAAKLKLESSSLKVKGEILLE---EEKSTDFV 1050
K+SG E+ +A+TK K +++K K++ + + L + +E S D
Sbjct: 923 KLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDK 982
Query: 1051 FIPPEGKDAKERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEPMEIPTLTR 1110
+G + K++ +D +K+V+K M + S D +EE P +
Sbjct: 983 KQSKKGTEEKKK-PSDFKKKVIK--------MEQQYESSSDGTEKLPEREEICHFPKGIK 1033
Query: 1111 KPKEDSKMMITEEQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNEC-GSLDKTSPEMSNSN 1169
+ K + T+ + S + + + ++++ EKS+ + C S DK S +
Sbjct: 1034 QIKNGT----TDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGR 1089
Query: 1170 NDERKKALISSRKTSTECASSTENSFVVSSSSVSNTTVAGTPPYPTSRRQTFI---TLEK 1226
+R K L S + +C+SS + + +++ RR T E
Sbjct: 1090 EKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEI 1149
Query: 1227 FDGSENRPFSPSPLNNISSTVTVKNNQETMI-----KTDFLPKAKQREGTFSKSDSEKIV 1281
GS + S +N + ++ +I + K+++ + S S I
Sbjct: 1150 QSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIE 1209
Query: 1282 NGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEGIVVLENNPPGLLNQTECVSDN 1341
+ + S EQ ++ L+ S + S G L + P ++ + +D
Sbjct: 1210 DDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSS--GDEALSKSVPVTVDDDDDDNDP 1267
Query: 1342 QVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVEINLESKENTPPVVISADQMVNE 1401
+ +++ + + +KA + + EE +++EN P A VN
Sbjct: 1268 ENRIAKKMLLEE---IKANLSSDEDGSSDDEPEEGKKRTGKQNEEN--PGDEEAKNQVNS 1322
Query: 1402 DSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQK-------KERRK-----EEEK 1449
+S ++K R R ++ S ES +++ + K + RRK E+
Sbjct: 1323 ESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDS 1382
Query: 1450 PLQKSPL-----HIKDDVLPKQKLIAEQTLQEN-------LIEKGSNLHEKTLGETSANA 1497
Q+S + +D+ P+ + + L+EN + + E + E +N+
Sbjct: 1383 DFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNS 1442
Query: 1498 ETEQNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSS 1557
E E+ +K+ + E + E + +D D S+ +GR + + L + +N+ +
Sbjct: 1443 EEEEEEKEEEEEEEEEEEEEEEDEND-DSKSPGKGRKKIRKILKDDKLRTETQNALKEEE 1501
Query: 1558 EAKEEGSRKKRSGKWKNKSNESVDIQD 1584
E ++ + ++R + K E ++I+D
Sbjct: 1502 ERRKRIAERERE---REKLREVIEIED 1525
Score = 56.6 bits (135), Expect = 3e-07
Identities = 199/1035 (19%), Positives = 364/1035 (35%), Gaps = 239/1035 (23%)
Query: 1276 DSEKIVNGTKRSSRRAGKAEQTGNKRSKPLMRSEPE---KNTEESVEGIVVL--ENNPPG 1330
DSE + +R K+ TG + K + EP+ NT E ++ +V + P
Sbjct: 470 DSEHMHQNVPTEEQRTNKS--TGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPED 527
Query: 1331 LLNQTECVSDNQVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVEINLESKENTPP 1390
+ E + Q S+++H E VE +V++N+ SK+N
Sbjct: 528 IFENLETAMEVQ-----SSVDHQGDGSSGTEQE---------VESSSVKLNISSKDNRGG 573
Query: 1391 VVISADQMVNEDSQVQITP----------------------------NQK---------- 1412
+ V ++ V++TP N K
Sbjct: 574 IKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQEN 633
Query: 1413 -------------TLRRSSRRRSEVVEST-----------TESQDKENSHQKKER----- 1443
L S RRS V++T T + D+E + KE+
Sbjct: 634 SDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSV 693
Query: 1444 --RKEEEKPLQKSPL-HIKDDVLPKQKLIAEQTLQEN--------LIEKGSNLHEKTLGE 1492
RK++++ S + + K + LPK K +T+ +N ++++ S + + +
Sbjct: 694 PVRKKDKRNSSDSAIDNPKPNKLPKSK--QSETVDQNSDSDEMLAILKEVSRMSHSSSSD 751
Query: 1493 TSAN-----------AETEQNKKKADPENIKSEGDGT--QDIVDKSSEKLVRGRTRYQTR 1539
T N +T+ K KS G+ KS++ + + + QT+
Sbjct: 752 TDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQ 811
Query: 1540 RASQGLLSSIENSESDSSEAKEEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAEN 1599
S S +E S+ + KKR K+ + ++EK K+ +N
Sbjct: 812 SESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDS------SEDEKHSKK---GMDN 862
Query: 1600 QSHDYKATSEEDVSIKSPICEKQDESNTVICQDSTVTSD--LLQVPDDLPNVCEEKNETS 1657
Q H TS+E S E++ E T + TV D ++++ D LP + T
Sbjct: 863 QGHKNLKTSQEG---SSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTD 919
Query: 1658 -----KYAEYSFTSLPV--------PESNLRTRNAIK----------RLHKRDSFDNCSL 1694
E SFTSL V +L+T+ K + K+D D S
Sbjct: 920 GVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSE 979
Query: 1695 GE--SSKIGISDISSLSE--KTFQTLECQHKRS-----------------RRVRRSKGCD 1733
+ SK G + S+ K +E Q++ S + +++ K
Sbjct: 980 DDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGT 1039
Query: 1734 CCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHS 1793
GEK + + K E +D T K D ++S+ G + E
Sbjct: 1040 TDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGD------SCDSSEDKKSKNGAYGRE--- 1090
Query: 1794 VNFHLGLKEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQE 1853
K+ + S + S +T + S+ +E+ C+ +E +E
Sbjct: 1091 -------KKRCKLLGKSSRKRQDCSSSDTEKYSM-------KEDGCNSSDKRLKRIELRE 1136
Query: 1854 SPNENFK--TVGPCLGDSKNVSQESLETKEEKPEET----------PKMELSLENVTVEG 1901
N + K T G S + ++ES E ++K + T K SL T
Sbjct: 1137 RRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRK 1196
Query: 1902 NACKVTESNLEKAKTMELNVGNEASFHGQE----------RTKTGISEEAAIEENKR--- 1948
A +T S+ + + N E S Q+ + TG + + E +
Sbjct: 1197 QA-DITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVP 1255
Query: 1949 ----NDDSEADTAKLNAKEVATEEFNSDISL----SDNTTPVKLNAQTEISEQTAAGELD 2000
+DD + D AK++ EE +++S S + P + +T + G+ +
Sbjct: 1256 VTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEE 1315
Query: 2001 GGNDV-SDLHSSEETNTKMKNNEEMMIGEAMAETGHDGE------TENEGITTKTSKPDE 2053
N V S+ S E + K + ++ + G GE E++ + + +
Sbjct: 1316 AKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVS 1375
Query: 2054 AETNMLTAEMDNFVCDTVEMSTEE---GIIDANKTETNTEYSKSEEKLDNNQMVMESDIL 2110
+E + + ++ V + V S +E A K E ++K ++ ++ D
Sbjct: 1376 SEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSS 1435
Query: 2111 QEDHHTSQKVEEPSQ 2125
E+ S++ EE +
Sbjct: 1436 SENKSNSEEEEEEKE 1450
Score = 49.3 bits (116), Expect = 5e-05
Identities = 115/575 (20%), Positives = 221/575 (38%), Gaps = 70/575 (12%)
Query: 975 MEESSGPYSDGTENSQLNVKI----SGMERKSNGKRDSFLAQTKNKKENMKPAAKLKLES 1030
ME+ SDGTE +I G+++ NG D K + + K +L +
Sbjct: 1005 MEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYA 1064
Query: 1031 SSLKVKGEIL--LEEEKSTDFVFIPPE------GKDAKER---ILTDHQKEVLKTKRCDI 1079
KG+ E++KS + + + GK +++R +D +K +K C+
Sbjct: 1065 EKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCN- 1123
Query: 1080 PAMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITEEQMDSDIVIPQDVTEDC 1139
S ++ ++ L + SK E Q S ++ +ED
Sbjct: 1124 ------------------SSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSED- 1164
Query: 1140 GMAEHLEKSSLSNNECGSLDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSS 1199
+K S+ + + K S + +RK+A I+S +S++ +NS S
Sbjct: 1165 ---NKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITS-SSSSDIEDDDQNSIGEGS 1220
Query: 1200 SSVSNTTVAGTPPYPTSRRQTFITLEKF-DGSENRPFSPSPLNNISSTVTVKNNQETMIK 1258
S P + + F S + S S + + + + K
Sbjct: 1221 SDEQKIK-------PVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAK 1273
Query: 1259 TDFLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKA--EQTGNKRSKPLMRSEPEKNTEE 1316
L + K + S+ + + +R GK E G++ +K + SE + ++EE
Sbjct: 1274 KMLLEEIKANLSSDEDGSSD---DEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEE 1330
Query: 1317 SVEGIVVLENNPPGLLNQTECVSDNQVHLSESTM--EHDNTKLKAATVENAVLLETNTVE 1374
S + LL VSD + + T EH K + ++ E + +
Sbjct: 1331 SKK-----PRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQ 1385
Query: 1375 EKNVEINL-ESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQD 1433
E V + ES++ P SA + ++ NQ++ ++ +RR V+ + S++
Sbjct: 1386 ESGVSEEVSESEDEQRPRTRSA-------KKAELEENQRSYKQKKKRRRIKVQEDSSSEN 1438
Query: 1434 KENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGET 1493
K NS +++E ++EEE+ ++ ++D K + + I K L +T +
Sbjct: 1439 KSNSEEEEEEKEEEEEE-EEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTET--QN 1495
Query: 1494 SANAETEQNKKKADPENIKSEGDGTQDIVDKSSEK 1528
+ E E+ K+ A+ E + + +I D S K
Sbjct: 1496 ALKEEEERRKRIAEREREREKLREVIEIEDASPTK 1530
Score = 38.1 bits (87), Expect = 0.11
Identities = 105/504 (20%), Positives = 183/504 (36%), Gaps = 82/504 (16%)
Query: 1797 HLGLKED-------NDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSL 1849
HL L+ED D +N E K + + G E D+ SEA
Sbjct: 406 HLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLS 465
Query: 1850 ESQ---ESPNENFKTVGPCLGDSKNVSQESLETKEE---KPEETPKMELSLENVTVEGNA 1903
Q E ++N T S + + KEE +P T + +L ++ V+V +
Sbjct: 466 RKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSE-DLDMDIVSVPSSV 524
Query: 1904 CKVTESNLEKAKTMELNVGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAKE 1963
+ NLE A ++ +V ++ G T+ + E ++++ N + D+ +
Sbjct: 525 PEDIFENLETAMEVQSSVDHQGD--GSSGTEQEV-ESSSVKLNISSKDNRGGIKSKTTAK 581
Query: 1964 VATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKMKNNEE 2023
V E + +S + +P+K E+ + D + S N K+ E+
Sbjct: 582 VTKELYVKLTPVSLSNSPIKGADCQEVPQD------------KDGYKSCGLNPKL---EK 626
Query: 2024 MMIGEAMAETGHDGETENEGITTKTSKPDEAETNMLTAEMDNFVCDTVEMSTEEGIIDAN 2083
+G+ ++NE + E E ++L E D V+ +
Sbjct: 627 CGLGQE--------NSDNEHLV-------ENEVSLLLEESDLRRSPRVKTTPLR-----R 666
Query: 2084 KTETNTEYSKSEEKLDNNQMVMESDILQEDHHTSQKVEEPSQCLASGTAISELIIEDNNA 2143
TETN S S+E+ + + ++E S V + + +S +AI +N
Sbjct: 667 PTETNPVTSNSDEECN--------ETVKEKQKLSVPVRKKDKRNSSDSAI-------DNP 711
Query: 2144 SPQKLRELDPSLVSANDSPSGMQTRCVWSPLASPSTSILKRGLKRSQEDEISSPVNKVR- 2202
P KL + S +S S +ILK + S + +N++
Sbjct: 712 KPNKLPKSKQSETVDQNSDS------------DEMLAILKEVSRMSHSSSSDTDINEIHT 759
Query: 2203 -RVSFADPIYQAGLADDIDRRCSIVRSHSSNSSPIGKSVKTSPTTQSKHNTTSAKGFLSP 2261
+ D QAG D R+ S S + GKS K+S ++ K T S
Sbjct: 760 NHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYD- 818
Query: 2262 GSRSPKFKSSKKCLISEMAKESIP 2285
+ KS K + K+ IP
Sbjct: 819 SELEKEIKSMSKIGAARTTKKRIP 842
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 74.3 bits (181), Expect = 1e-12
Identities = 163/837 (19%), Positives = 322/837 (38%), Gaps = 128/837 (15%)
Query: 1353 DNTKLKAATVENAVLLETNTVEE--KNVEINLESKENTP-PVVISADQMVNEDSQVQITP 1409
D + K T E+ E +T + + +E +S+E + P + + ++ I
Sbjct: 244 DTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILL 303
Query: 1410 NQKTLRRSSRRRSEVVESTTESQDKENSHQKKERRKEEEKPLQKSPLH---------IKD 1460
N+ + SS ++++ ST + + K +S++K ER+KE+++ +K H +KD
Sbjct: 304 NKDVQQESSEQKNK---STDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKD 360
Query: 1461 DVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSAN---------------------AET 1499
+ K+K + L EK SN KT+ T + ++
Sbjct: 361 EKQAKEKEVESLKLPS---EKNSN-KAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDL 416
Query: 1500 EQNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIEN-------- 1551
++ + E + S+ +I EK + +T+ QT +S+G S+ +
Sbjct: 417 SSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYL 476
Query: 1552 -----SESDS----SEAKEEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQ-- 1600
S+SD + ++ +++K + + N + +++K K + K + Q
Sbjct: 477 YSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGR 536
Query: 1601 -SHDYKATSEEDVSIKSPICEKQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKY 1659
S D + +S + + K+ ++ + V+ + ++ + D NV E + +Y
Sbjct: 537 SSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSK---KRKKDSRNVEENSKKKQQY 593
Query: 1660 AEYSFTSLPVPE----SNLRTRNAIKRLHKRDSFDNCSLGESSKIGISDISSLSEKTFQT 1715
E S +L E + + +K +H + + S + + D K
Sbjct: 594 EEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVD----ENKNESK 649
Query: 1716 LECQHKR----------------SRRVRRS-KGCDCCGEKSQPQEKSLIGLKNTENNDVE 1758
LE +HKR +R V+R + + C E+ Q Q+ +L K+ + +D E
Sbjct: 650 LEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSE 709
Query: 1759 ISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGLKEDNDTINDSLIVSE--T 1816
K + S E + L H K ++T L SE
Sbjct: 710 TPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDET---ELHSSEKGL 766
Query: 1817 KSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTVGPCLGDSKNVSQES 1876
K +EN ++S + ++ D +E ++S + N + + D K VS+
Sbjct: 767 KVEENIQKQSQ-------QTKLSSDDKTE------RKSKHRNERKLSVLGKDGKPVSEYI 813
Query: 1877 LETKEEKPEETPKME--LSLENVTVEGNACKVTESNLEKAKTMELNVGNEASFHGQERTK 1934
++T E +E K E LS E E + + ++S ++K S ++
Sbjct: 814 IKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQK-----------DSLGSKQHGI 862
Query: 1935 TGISEEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTTPVKLNAQTEISE-Q 1993
T + E+K + DS + L +EV +E SL + +K ++T+ + +
Sbjct: 863 TLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVK 922
Query: 1994 TAAGELDGG------NDVSDLHSSEETNTKMKNNEEMMIGEAMAETGHDGETENEGITTK 2047
EL G D + E N K + + + ETG + E +
Sbjct: 923 VVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAH 982
Query: 2048 TSKPDEAETNMLTAEMDNFVCDTVEMST--EEGIIDANKTETNTEYSKSEEKLDNNQ 2102
+++ D + L + + D ST E + D +K+ + SK +K D N+
Sbjct: 983 STQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENK 1039
Score = 64.3 bits (155), Expect = 1e-09
Identities = 238/1281 (18%), Positives = 471/1281 (36%), Gaps = 186/1281 (14%)
Query: 958 AKQKFLLLLPGLETVEMMEESSGPYSDGTENSQLNVKISGMERKSNGKRDSFLAQTKNKK 1017
AK+K LL E +EE ++ T++S K G R S +S + K
Sbjct: 498 AKEKEERLLRRQINREKLEEKRKQKAEKTKSS----KTKGQGRSSVDLEESSTKSLEPKA 553
Query: 1018 ENMKPAAKLKLESSSLKVKGEILLEEEKSTDFVFIPPEGKDAKERILTDHQKEVLKT-KR 1076
+K K E L+ K + + +K + V E K++ + KE LKT +
Sbjct: 554 ARIKEVLK---ERKVLEKKVALSKKRKKDSRNV----EENSKKKQQYEEDSKETLKTSEH 606
Query: 1077 CDIPAMYNNLDVSQDTLFTQYSQ--EEPMEIPTLTRKPKEDSKMMITEEQMDSDIVIPQD 1134
C+ + ++ ++ ++ S+ E + + K +SK+ ++ S VI +
Sbjct: 607 CEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEG 666
Query: 1135 VTEDCGMAE---HLEKSSLSNNECGSLDKTSPEMSNSNNDERK----KALISSRKTSTEC 1187
V E+ + +E+S + E T + D+ + K+L+ S++
Sbjct: 667 VQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKE 726
Query: 1188 ASSTENSFVVSSSSVSNTTVAGTPPYPTSRRQTFITLEKFDGSENRPFSPSPLNNISSTV 1247
E + SV + G + T + EK E S +SS
Sbjct: 727 KPEREKTPSEDKLSVKHK-YKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDD 785
Query: 1248 TV--KNNQETMIKTDFLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRSKPL 1305
K+ K L K + + E + + RR + +S+
Sbjct: 786 KTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRS 845
Query: 1306 MRSEPEKNTEESVEGIVVLENNPPGLLNQTECVSDNQVHLSESTMEHDNTKLKAATVENA 1365
S+ +K++ S + + L+ ++E S+++ + + M+ + LK V +
Sbjct: 846 SDSKIQKDSLGSKQHGITLQR-------RSESYSEDKCDMDSTNMD---SNLKPEEVVHK 895
Query: 1366 VLLETNTVEEKNVEINLESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEVV 1425
T ++ E+ + + +SK + QV++ + L+ + +++
Sbjct: 896 EKRRTKSLLEEKLVLKSKSK--------------TQGKQVKVVETE--LQEGATKQATTP 939
Query: 1426 ESTTESQDKENSHQKKERRKEEEKPLQKSPLH------------IKDDVLPKQKL-IAEQ 1472
+ E +EN +K+ + K E+KP +++ + + D + KL +A++
Sbjct: 940 KPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKE 999
Query: 1473 TLQENLIEKGSNLHEKTL-GETSANAETEQNKKKADPENIKSEGDGTQDIVDKSSEKLVR 1531
+ + + L K G S + + K EN + DG + VD S EK R
Sbjct: 1000 KYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKE--VDSSHEK-AR 1056
Query: 1532 GRTRYQTRRASQGLLSSIENSESDSSEAKEE-----------GS---RKKRSGKWK---N 1574
G + ++ S+ L + S S EE GS R K+SG
Sbjct: 1057 GNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPE 1116
Query: 1575 KSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDESNTVICQDST 1634
+ +D + E V + + ++ + E++ K+ ++DE T DS
Sbjct: 1117 QEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCTA-DSK 1175
Query: 1635 VTSDLLQVPDDLPNVCEEKNETS-KYAEYSFTSLPVPESNLRTRNAIKRLHKRDSFDNCS 1693
T+ P P N S K+A++ T K++H + + +
Sbjct: 1176 ATA-----PAYKPGRGTGVNSNSEKHADHRST-------------LTKKMHIQSAVSKMN 1217
Query: 1694 LGESSKI--GISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQEKSLIGLKN 1751
GE I G ++++ SE + L + RV+++ E + +L
Sbjct: 1218 PGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKNTAAEEHVAQGDATL----- 1272
Query: 1752 TENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVNF----HLGLKEDNDTI 1807
+ +++ S + + P+ S P + + + E + + H L + T+
Sbjct: 1273 EHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTVLEGSTASTSPADHSALPNQSLTV 1332
Query: 1808 NDSLIVSETKSKEN----TMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTVG 1863
+S ++ + SKE T+ + I + R ++ +A L+ ++ K +
Sbjct: 1333 RESEVLKTSDSKEGGEGFTVDTPAKASITSKRHI---PEAHQATLLDGKQG-----KVIM 1384
Query: 1864 PCLGDSKNVSQESLE-TKEEKPEETPKMELSLENVTVEGNACKVTESNLEKAKTMELNVG 1922
P V E+ TKE + K E ++ E N + ++ +E K + V
Sbjct: 1385 PLGSKLTGVIVENENITKEGGLVDMAKKE---NDLNAEPNLKQTIKATVENGKKDGIAVD 1441
Query: 1923 NEASFHGQERTKT---------GISEEAAIEENKRNDDSEADT----------------- 1956
+ + ++ +T G ++ +I+ +RN++SE DT
Sbjct: 1442 HVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNGQ 1501
Query: 1957 ----------AKLNAKEVATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGELDGGNDVS 2006
A+ + +TE + D++LS PVK T S +T E+
Sbjct: 1502 TEDVATGPRRAEKTSVATSTEGKDKDVTLS----PVKAGPATTTSSETRQSEVALPCTSI 1557
Query: 2007 DLHSSEETNTKMKNNEEMMIGE-------AMAETG----HDGETENEGITTKTSKPDEAE 2055
+ T +NN + E A AE G +G E+E T T + + E
Sbjct: 1558 EADEGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEGFAESETFLTSTKEGESGE 1617
Query: 2056 TNMLTAE---MDNFVCDTVEMSTEEGIIDANKTETNTEYSKSEEKLDNNQMVMESDILQE 2112
+ +E D V++ + + + + SEEK D + + +S+I++
Sbjct: 1618 CAVAESEDRAADLLAVHAVKIEANVNSVVTEEKDDAVTSAGSEEKCDGS-LSRDSEIVEG 1676
Query: 2113 DHHTSQKVEEPSQCLASGTAI 2133
+VE ++GT I
Sbjct: 1677 TITFISEVESDGAVTSAGTEI 1697
Score = 40.0 bits (92), Expect = 0.028
Identities = 97/467 (20%), Positives = 174/467 (37%), Gaps = 65/467 (13%)
Query: 1750 KNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGLKEDNDTIND 1809
K ++N S ++ D+ VS S+ N G +E +N GLK + +
Sbjct: 2621 KTGDDNSTRKSFPEEGDIMVTVS----SEENVCDIG---NEESPLNVLGGLKLKANLKME 2673
Query: 1810 SLIVSETKSKENTMQ--ESL----PSGIVNFREEICDMDSSEAMSLESQESPNENFKTVG 1863
+ + SE + + ESL PSGI + E + +E++++E N F+T
Sbjct: 2674 AYVPSEEEKNGEILAPPESLCGGKPSGIAELQRE--PLLVNESLNVE-----NSGFRTNE 2726
Query: 1864 PCLGDSKNVSQESLETKEEKPEETPKMELSLENVTVEGNACKVTESNLEKAKTMELNVGN 1923
+S N + S K+ +S +V + + E ++ K K + + +
Sbjct: 2727 EIHSESYNKGEISSGRKDNAEA------ISGHSVEADPKEVEEEERHMPKRKRKQHYLSS 2780
Query: 1924 EASFHGQERTKTGISEEAAIEENKRN--DDSEADTAKLNAKEVATEEFNSDISLSDNTTP 1981
E E ++ IE +R + DT + N++++ EE S +++TT
Sbjct: 2781 E-----DEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDL--EELPKTSSETNSTTS 2833
Query: 1982 VKLNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKMKNNEEMMIGEAMAETGHDGETEN 2041
+ + E S GE ND + S EE + + + ET
Sbjct: 2834 RVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVET-------- 2885
Query: 2042 EGITTKTSKPDEAETNMLTAEMDNFVCDTVEMSTEEGIID-ANKTETNTEYSKSEEKLDN 2100
T K + +T ++T E M T+E + AN E + EEK+
Sbjct: 2886 ---TLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVT 2942
Query: 2101 N-----QMVMESDILQEDHHTSQKVEEPSQCLASGTAISELIIEDNNASPQKLRELDPSL 2155
+ + S + +D +S+ + + ++ +ED E +
Sbjct: 2943 SVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDP-------VEDKKEQESDEEEEEEE- 2994
Query: 2156 VSANDSPSGMQTRCVWSPLASPSTSILKRGLKRSQEDEISSPVNKVR 2202
D PSG TR A S + L +KR + E+S P + R
Sbjct: 2995 ---EDEPSGATTRSTTRSEAQRSKTQLSPSIKRKR--EVSPPGARTR 3036
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 73.2 bits (178), Expect = 3e-12
Identities = 232/1201 (19%), Positives = 455/1201 (37%), Gaps = 195/1201 (16%)
Query: 1188 ASSTENSFVVSSSSVSNTTVAGTPPYPTSRRQTFITLEKFDGSENRPFSPSPLNNISSTV 1247
+ +T + + +SS+ + ++A TP P S QT T P+P+ I ST
Sbjct: 619 SQTTGVAIPLHASSLDDVSLASTPKRP-STSQTVST-------------PAPVPVIESTE 664
Query: 1248 TVKNNQETMIKTDFLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRSKPLMR 1307
++ KQ + F EK N ++ + EQ + RS+
Sbjct: 665 AIEAKAAL----------KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKI 714
Query: 1308 SEPEKNTEESVEGIVVLENNPPGLLNQTECVSDNQVHLSESTMEHD---NTK---LKAAT 1361
S + E +L++N G + + + L+ +T + + NT L+ A
Sbjct: 715 STQLDFASKRYE---MLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGAN 771
Query: 1362 VENAV--LLETNTVEEKNVEINLESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSSR 1419
+ AV + N +EK + E + + + A+Q + Q L RS
Sbjct: 772 EKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSET 831
Query: 1420 RRSEVVESTTESQDKENSHQKKERRKEEEKPLQ------------------KSPLHIKDD 1461
+ + S E + E SH KK+ E E+ ++ LH+
Sbjct: 832 ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTK 891
Query: 1462 VLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQNKKKADPENIKSEGDGTQDI 1521
L K TL+++L SN+ + ++S Q K D +++ S+ T++
Sbjct: 892 ELLKNAQKEIATLKQHL----SNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQ 947
Query: 1522 VDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWKNKSNESVD 1581
V+ E+L +T Q +++S+E S + + EE RK + K ES +
Sbjct: 948 VNDLKERL---KTSTSNVEQYQAMVTSLEESLNKEKQVTEE-VRKNIEVRLK----ESAE 999
Query: 1582 IQDQ-EEKVVKQECIKAENQSHDYKA--TSEEDVS-IKSPICEKQDESNTVICQDSTVTS 1637
Q Q E+K+++ E K E Q +A + E+ +S +K + Q+E + + ST S
Sbjct: 1000 FQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALS 1059
Query: 1638 DLLQVPDDLPNVCEEKNETSKYAEYSF-TSLPVPESNLRTRNAIKRLHKRDSFDNCSLGE 1696
+ Q D C+E+ + + A+ + L + +++ A K + S
Sbjct: 1060 NEQQARRD----CQEQAKIAVEAQNKYERELMLHAADVEALQAAK--------EQVSKMA 1107
Query: 1697 SSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKG----CDCCGEKSQPQEKSLIGLKNT 1752
S + + + + +E Q LEC+ R R K C C E + Q + L
Sbjct: 1108 SVRQHLEETTQKAES--QLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLL--HDQI 1163
Query: 1753 ENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGLKEDNDTINDSLI 1812
E ++ + K VQ P++ S + + S+ Q L+ + F KE +T +
Sbjct: 1164 EKLSDKVVASVKEGVQGPLNVSLSEEGK--SQEQILE---ILRFIRREKEIAETRFEVAQ 1218
Query: 1813 VSETKSK------ENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTVGPCL 1866
V + + E +QE L + RE++ A ++ E + +T+ +
Sbjct: 1219 VESLRYRQRVELLERELQE-LQDSLNAEREKV----QVTAKTMAQHEELMKKTETMNVVM 1273
Query: 1867 GDSKNVSQESLETKEEKPEETPKMELSLENVTVEGNACKVTESNLEKAKTMELNVGNEAS 1926
+K + +E KE ++ +M+ + +E + + E+N E ++ + +
Sbjct: 1274 ETNKMLREE----KERLEQDLQQMQAKVRK--LELDILPLQEANAELSEKSGMLQAEKKL 1327
Query: 1927 FHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEF---------------NS 1971
+E K + + +++ D+E L+ KEV T+ S
Sbjct: 1328 L--EEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARS 1385
Query: 1972 DISLSDNTTPVK-----LNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKMK------- 2019
+ SL++N ++ LN + ++T +LD + D+ +T T++K
Sbjct: 1386 NASLTNNQNLIQSLKEDLN-KVRTEKETIQKDLDA--KIIDIQEKVKTITQVKKIGRRYK 1442
Query: 2020 ------NNEEMMIGEAMAETGHDGETENEGI-----TTKTSKPDEAETNMLTAEMDNFVC 2068
++ + E A++ D + ++ + +T E ++ L ++++N
Sbjct: 1443 TQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQK 1502
Query: 2069 DTVEMSTEEGIIDANKTETNTEYSKSEEKLDN---NQMVMESDILQEDHHTSQKVEEPSQ 2125
E TE + + +E S+ + L + + + I +++ T + +
Sbjct: 1503 TLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKS 1562
Query: 2126 CLASGTAISELIIED-------NNASPQKLRELDPSLVSANDSPSGMQTRCVWSPLASPS 2178
+A + + + ++ N A Q+ ELD + + G +R
Sbjct: 1563 KIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISR---------- 1612
Query: 2179 TSILKRGLKRSQE------DEISSPVNKVRRVSFADPIYQAGLADDIDRRCSIVRSHSSN 2232
L+R L+ QE DE P NKV + + + R +S
Sbjct: 1613 ---LERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGE--------RGIAST 1661
Query: 2233 SSPIGKSVKTSPTTQSKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPTESVY 2292
S P ++K +P + T+A G++S S + + PT +V
Sbjct: 1662 SDPPTANIKPTPVVSTPSKVTAA---AMAGNKSTPRASIRPMVTPATVTNPTTTPTATVM 1718
Query: 2293 P 2293
P
Sbjct: 1719 P 1719
Score = 42.0 bits (97), Expect = 0.007
Identities = 154/853 (18%), Positives = 323/853 (37%), Gaps = 109/853 (12%)
Query: 1324 LENNPPGLLNQT-ECVSDNQVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVEINL 1382
L ++ L+N+T EC S +E N +LKA T +N E +++N+ I
Sbjct: 61 LSHSQERLVNETRECQS------LRLELEKLNNQLKALTEKNK---ELEIAQDRNIAIQS 111
Query: 1383 ESKENTPPVVISADQMVNEDSQVQ-----ITPNQKTL----RRSSRRRSEVVESTTESQD 1433
+ + ++ + ++ +T + K L + S+ + E+ E Q
Sbjct: 112 QFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQA 171
Query: 1434 KENSHQKKERRKEEEKPL---QKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTL 1490
+ S + +E+R E+EK L Q + L+ + + L + ++E NL K
Sbjct: 172 SDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK- 230
Query: 1491 GETSANAETEQNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIE 1550
E + E + N K E+++ + + ++ E+ ++ + LS++
Sbjct: 231 -EEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLY 289
Query: 1551 NSESDSSEAK--------EEGSRKKRSGKWKNKS--NESVDIQDQEEKVVKQECIK---- 1596
S +D SEAK EE + + NK+ + ++++ ++++ K+ K
Sbjct: 290 KSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRL 349
Query: 1597 ---AENQSHDYKAT-------SEEDVSIKSPICEKQDESNTVICQDSTVTSDLLQVPDDL 1646
EN + AT SEE+++ SP + + + + + ++ D L
Sbjct: 350 EKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQL 409
Query: 1647 PNVCEEKNETSKYAEYSFTSLPVPESNL-RTRNAIKRLHKRDSFDNCSLGESSKIGISDI 1705
E +KY + + L R R +R K + SL + + +I
Sbjct: 410 LLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVA----SLSVKLEQAMKEI 465
Query: 1706 SSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQEKSLIGLKNTENNDVEISETKKA 1765
L E T + +K+S + R + + Q K L ++ V + E ++A
Sbjct: 466 QRLQEDT----DKANKQSSVLERD------NRRMEIQVKDL-----SQQIRVLLMELEEA 510
Query: 1766 DVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGLKEDNDTINDSLIVS-----ETKSKE 1820
+ E S A+ S + + +H ++ E+ N L+V+ ET+ +E
Sbjct: 511 RGNHVIRDEEVSSADISSSSEVISQHLVSYRNI---EELQQQNQRLLVALRELGETRERE 567
Query: 1821 NTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTVGPCLGDSKNVSQESLETK 1880
QE+ S I + ++ S LE ++ + + +++ + L
Sbjct: 568 E--QETTSSKITELQLKL----ESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILL--S 619
Query: 1881 EEKPEETPKMELSLENVTVEGNACK-VTESNLEKAKTMELNVGNEASFHGQERTKTGISE 1939
+ P SL++V++ + T + + + EA K + +
Sbjct: 620 QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAI-----EAKAALKQ 674
Query: 1940 EAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGEL 1999
I EN + + +E + + E E+ +D+ + +L+ ++ E
Sbjct: 675 LQEIFENYKKEKAENEKIQNEQLEKLQEQV-TDLRSQNTKISTQLDFASKRYEMLQDNVE 733
Query: 2000 DGGNDVSDLHSSEETNTKMKNNEEMMIGE------------AMAETGHDGETENEGITTK 2047
+++ LH + T +E +I A+AE + + + +
Sbjct: 734 GYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKL 793
Query: 2048 TSKPDEAETNMLTAEMDNFVCDTVEMSTEEGIIDANKTETNTEYSKSEEKLDNN----QM 2103
+ + L AE + T +GI++ ++TET S EKL++ +
Sbjct: 794 SEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKK 853
Query: 2104 VMESDILQEDHHT 2116
+E+++ E HT
Sbjct: 854 KLENEV--EQRHT 864
>gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo
sapiens]
Length = 1257
Score = 72.4 bits (176), Expect = 5e-12
Identities = 155/748 (20%), Positives = 279/748 (37%), Gaps = 112/748 (14%)
Query: 1309 EPEKNTEESVEGIVVLENNPPGLLNQTECVSDNQVHL-SESTMEHDNTKLKAATVENAVL 1367
E +K+ EES+E + L+ P TE S+ + ++ S S E + +LK+ +
Sbjct: 419 EEKKDLEESMEEALKLDQEMP----LTEVKSEPEENIDSNSESEREEIELKSPRGRRRIA 474
Query: 1368 LETNTVEEKNVEINLESK---ENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEV 1424
+ N+++++ E E K +T + D E + ++ +K + ++ +
Sbjct: 475 RDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKK 534
Query: 1425 VESTTESQDKENSHQKKERRKEEEKPLQKSPLHIKDDVLP--------------KQKLIA 1470
E + + D+E +K + R+E E ++D+ P K + I
Sbjct: 535 QEDSDKDSDEEE--EKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIY 592
Query: 1471 EQTLQENLIEKGSNLH-----------------EKTLGETSANAETEQNKKKADPENIKS 1513
E +++ I+ G L+ ++ + ++ KKKA K+
Sbjct: 593 EASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKA-----KN 647
Query: 1514 EGDGTQDIV-DKSSEKLVRGRTRYQTRRASQGL--LSSIENSESDSSEAKEEGSRKKRSG 1570
+ D +D D+ +K RGR ++ +S LS NSE S + +
Sbjct: 648 KEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDS--ETEDA 705
Query: 1571 KWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDESNTVIC 1630
KN NE + ++D+ EK N++ + EE+ I + I ++ D +
Sbjct: 706 LEKNLINEELSLKDELEK----------NENLNDDKLDEENPKISAHILKENDRTQMQPL 755
Query: 1631 QDSTV-TSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLR---TRNAIKRLHKR 1686
+ + + Q+ N E+ E K AE S P+ R T++ + K
Sbjct: 756 ETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKS------PKGKGRRSKTKDLSLEIIKI 809
Query: 1687 DSFDNCSLGESSKIGIS--DISSLSEKTFQTL------EC------------QHKRSRRV 1726
SF G I ++SSL K F + +C Q +++
Sbjct: 810 SSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRKILGQSSPEKKI 869
Query: 1727 RRSKGCDCCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQ 1786
R G + SQ + IG + +N + E ++ + P +E++Q +
Sbjct: 870 RIENGMEMTNTVSQERTSDCIGSEGMKNLNFE-QHFERENEGMPSLIAESNQCIQQLTSE 928
Query: 1787 FLDEHHSVNFHLGLKEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEA 1846
D ++ LKED D + LI ET + L E++ ++SSE+
Sbjct: 929 RFDSPAEETVNIPLKEDEDAM--PLIGPETLVCHEVDLDDLDEKDKTSIEDVA-VESSES 985
Query: 1847 MSLES-----QESPNENFKTVGPCL---GDSKNVSQESLETKEEKPEETPKMELSLENVT 1898
SL S NF P +S++V ES T E E E +
Sbjct: 986 NSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDSIAEESQEGLCERES 1045
Query: 1899 VEGNACKVTESNLEKAKTMELNVGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAK 1958
G E+N+ + E+ GQ+R G S A ++ KR + AK
Sbjct: 1046 ANG-----FETNVASGTCSIIVQERESREKGQKRPSDGNSGLMA-KKQKRTPKRTSAAAK 1099
Query: 1959 LNAKEVATEEFNSDISLSDNT---TPVK 1983
+ D+ + DN+ TPVK
Sbjct: 1100 NEKNGTGQSSDSEDLPVLDNSSKCTPVK 1127
Score = 42.4 bits (98), Expect = 0.006
Identities = 166/814 (20%), Positives = 308/814 (37%), Gaps = 116/814 (14%)
Query: 1110 RKPKEDSKMMITEEQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNECGSLDKTSP----EM 1165
+K E+ K TE+++ + +DV +D AE E L + K E
Sbjct: 481 KKEIEEEK---TEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQED 537
Query: 1166 SNSNNDERKKALISSRKTSTECASSTENSFVVSSSSVSNTTVAGTPPYPTSRRQTF---- 1221
S+ ++DE ++ +T ++C S E ++ T V Y + Q
Sbjct: 538 SDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVK--VKYGRGKTQKIYEAS 595
Query: 1222 ITLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTDFLPKAKQREGTFSKSDSEKIV 1281
I + D E N+ VK ++ PK KQ++ +K DSEK
Sbjct: 596 IKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEK-- 653
Query: 1282 NGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEGIVVLENNPPGLLNQTECVSDN 1341
KR E+ +KR +P ++S L +N P L++T N
Sbjct: 654 -DEKRDE------ERQKSKRGRPPLKS--------------TLSSNMPYGLSKTA----N 688
Query: 1342 QVHLSESTMEHDNTKLKAATVENAVLLETNTV-EEKNVEINLESKENTPPVVISADQMVN 1400
S+S T E+A LE N + EE +++ LE EN ++ D++
Sbjct: 689 SEGKSDSCSSDSET-------EDA--LEKNLINEELSLKDELEKNEN-----LNDDKLDE 734
Query: 1401 EDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSH------QKKERRKEEEKPLQKS 1454
E+ ++ + L+ + R + + +E T + + EN K E+ +E +K +KS
Sbjct: 735 ENPKI----SAHILKENDRTQMQPLE-TLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKS 789
Query: 1455 PLHIKDDVLPKQKLIAEQTLQENL-IEKGSNLHEKTLGETSANAETEQNKKKADPENIKS 1513
PK K +T +L I K S+ + G D +N S
Sbjct: 790 ---------PKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSS 840
Query: 1514 --EGDGTQDIVDKSSEKLVRGRTRYQTR-RASQGL-LSSIENSESDSSEAKEEGSRKKRS 1569
E + Q + +K ++ + G++ + + R G+ +++ + E S EG +
Sbjct: 841 ATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNF 900
Query: 1570 GKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDE----- 1624
+ + NE + E +CI+ + S + + +EE V+I P+ E +D
Sbjct: 901 EQHFERENEGMPSLIAE----SNQCIQ-QLTSERFDSPAEETVNI--PLKEDEDAMPLIG 953
Query: 1625 SNTVICQDSTVTSDLLQVPD--DLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKR 1682
T++C + V D L D + +V E +E++ PV + N + +
Sbjct: 954 PETLVCHE--VDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPL-- 1009
Query: 1683 LHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQ 1742
++ S+ S I I ++ S++E++ + L C+ + + + C Q +
Sbjct: 1010 --TLSQDESRSVKSESDITI-EVDSIAEESQEGL-CERESANGFETNVASGTCSIIVQER 1065
Query: 1743 EKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGLKE 1802
E G K + + + K+ + P S ++ GQ D E
Sbjct: 1066 ESREKGQKRPSDGNSGLMAKKQK--RTPKRTSAAAKNEKNGTGQSSD-----------SE 1112
Query: 1803 DNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTV 1862
D +++S + K + + L I D + + SP +
Sbjct: 1113 DLPVLDNSSKCTPVKHLNVSKPQKLARSPARISPHIKDGEKDKHREKHPNSSPRTYKWSF 1172
Query: 1863 GPCLGDSKNVSQESLETKEEKPEETPKMELSLEN 1896
D+ N S E + +EK +E K +SL++
Sbjct: 1173 QLNELDNMN-STERISFLQEKLQEIRKYYMSLKS 1205
>gi|115334673 retinoblastoma-binding protein 1 isoform II [Homo
sapiens]
Length = 1203
Score = 70.9 bits (172), Expect = 2e-11
Identities = 154/754 (20%), Positives = 281/754 (37%), Gaps = 110/754 (14%)
Query: 1309 EPEKNTEESVEGIVVLENNPPGLLNQTECVSDNQVHL-SESTMEHDNTKLKAATVENAVL 1367
E +K+ EES+E + L+ P TE S+ + ++ S S E + +LK+ +
Sbjct: 419 EEKKDLEESMEEALKLDQEMP----LTEVKSEPEENIDSNSESEREEIELKSPRGRRRIA 474
Query: 1368 LETNTVEEKNVEINLESK---ENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEV 1424
+ N+++++ E E K +T + D E + ++ +K + ++ +
Sbjct: 475 RDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKK 534
Query: 1425 VESTTESQDKENSHQKKERRKEEEKPLQKSPLHIKDDVLP--------------KQKLIA 1470
E + + D+E +K + R+E E ++D+ P K + I
Sbjct: 535 QEDSDKDSDEEE--EKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIY 592
Query: 1471 EQTLQENLIEKGSNLH-----------------EKTLGETSANAETEQNKKKADPENIKS 1513
E +++ I+ G L+ ++ + ++ KKKA K+
Sbjct: 593 EASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKA-----KN 647
Query: 1514 EGDGTQDIV-DKSSEKLVRGRTRYQTRRASQGL--LSSIENSESDSSEAKEEGSRKKRSG 1570
+ D +D D+ +K RGR ++ +S LS NSE S + +
Sbjct: 648 KEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDS--ETEDA 705
Query: 1571 KWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDESNTVIC 1630
KN NE + ++D+ EK N++ + EE+ I + I ++ D +
Sbjct: 706 LEKNLINEELSLKDELEK----------NENLNDDKLDEENPKISAHILKENDRTQMQPL 755
Query: 1631 QDSTV-TSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLR---TRNAIKRLHKR 1686
+ + + Q+ N E+ E K AE S P+ R T++ + K
Sbjct: 756 ETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKS------PKGKGRRSKTKDLSLEIIKI 809
Query: 1687 DSFDNCSLGESSKIGIS--DISSLSEKTFQTL------EC------------QHKRSRRV 1726
SF G I ++SSL K F + +C Q +++
Sbjct: 810 SSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRKILGQSSPEKKI 869
Query: 1727 RRSKGCDCCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQ 1786
R G + SQ + IG + +N + E ++ + P +E++Q +
Sbjct: 870 RIENGMEMTNTVSQERTSDCIGSEGMKNLNFE-QHFERENEGMPSLIAESNQCIQQLTSE 928
Query: 1787 FLDEHHSVNFHLGLKEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEA 1846
D ++ LKED D + LI ET + L E++ ++SSE+
Sbjct: 929 RFDSPAEETVNIPLKEDEDAM--PLIGPETLVCHEVDLDDLDEKDKTSIEDVA-VESSES 985
Query: 1847 MSLES-----QESPNENFKTVGPCL---GDSKNVSQESLETKEEKPEETPKMELSLENVT 1898
SL S NF P +S++V ES T E E E +
Sbjct: 986 NSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDSIAEESQEGLCERES 1045
Query: 1899 VEGNACKVTESNLEKAKTMELNVGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAK 1958
G E+N+ + E+ GQ+R G S A ++ KR + AK
Sbjct: 1046 ANG-----FETNVASGTCSIIVQERESREKGQKRPSDGNSGLMA-KKQKRTPKRTSAAAK 1099
Query: 1959 LNAKEVATEEFNSDISLSDNTTPV-KLNAQTEIS 1991
+ D+ + DN+ + +N+ IS
Sbjct: 1100 NEKNGTGQSSDSEDLPVLDNSNELDNMNSTERIS 1133
Score = 41.2 bits (95), Expect = 0.013
Identities = 144/698 (20%), Positives = 270/698 (38%), Gaps = 102/698 (14%)
Query: 1110 RKPKEDSKMMITEEQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNECGSLDKTSP----EM 1165
+K E+ K TE+++ + +DV +D AE E L + K E
Sbjct: 481 KKEIEEEK---TEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQED 537
Query: 1166 SNSNNDERKKALISSRKTSTECASSTENSFVVSSSSVSNTTVAGTPPYPTSRRQTF---- 1221
S+ ++DE ++ +T ++C S E ++ T V Y + Q
Sbjct: 538 SDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVK--VKYGRGKTQKIYEAS 595
Query: 1222 ITLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTDFLPKAKQREGTFSKSDSEKIV 1281
I + D E N+ VK ++ PK KQ++ +K DSEK
Sbjct: 596 IKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEK-- 653
Query: 1282 NGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEGIVVLENNPPGLLNQTECVSDN 1341
KR E+ +KR +P ++S L +N P L++T N
Sbjct: 654 -DEKRDE------ERQKSKRGRPPLKS--------------TLSSNMPYGLSKTA----N 688
Query: 1342 QVHLSESTMEHDNTKLKAATVENAVLLETNTV-EEKNVEINLESKENTPPVVISADQMVN 1400
S+S T E+A LE N + EE +++ LE EN ++ D++
Sbjct: 689 SEGKSDSCSSDSET-------EDA--LEKNLINEELSLKDELEKNEN-----LNDDKLDE 734
Query: 1401 EDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSH------QKKERRKEEEKPLQKS 1454
E+ ++ + L+ + R + + +E T + + EN K E+ +E +K +KS
Sbjct: 735 ENPKI----SAHILKENDRTQMQPLE-TLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKS 789
Query: 1455 PLHIKDDVLPKQKLIAEQTLQENL-IEKGSNLHEKTLGETSANAETEQNKKKADPENIKS 1513
PK K +T +L I K S+ + G D +N S
Sbjct: 790 ---------PKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSS 840
Query: 1514 --EGDGTQDIVDKSSEKLVRGRTRYQTR-RASQGL-LSSIENSESDSSEAKEEGSRKKRS 1569
E + Q + +K ++ + G++ + + R G+ +++ + E S EG +
Sbjct: 841 ATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNF 900
Query: 1570 GKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDE----- 1624
+ + NE + E +CI+ + S + + +EE V+I P+ E +D
Sbjct: 901 EQHFERENEGMPSLIAE----SNQCIQ-QLTSERFDSPAEETVNI--PLKEDEDAMPLIG 953
Query: 1625 SNTVICQDSTVTSDLLQVPD--DLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKR 1682
T++C + V D L D + +V E +E++ PV + N + +
Sbjct: 954 PETLVCHE--VDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPL-- 1009
Query: 1683 LHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQ 1742
++ S+ S I I ++ S++E++ + L C+ + + + C Q +
Sbjct: 1010 --TLSQDESRSVKSESDITI-EVDSIAEESQEGL-CERESANGFETNVASGTCSIIVQER 1065
Query: 1743 EKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQAN 1780
E G K + + + K+ S + ++ N
Sbjct: 1066 ESREKGQKRPSDGNSGLMAKKQKRTPKRTSAAAKNEKN 1103
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 70.1 bits (170), Expect = 3e-11
Identities = 228/1238 (18%), Positives = 470/1238 (37%), Gaps = 190/1238 (15%)
Query: 949 EELKPVLTQAKQKFLLLLPGLETVEMMEESSGPYSDGTENSQLNVKISGMERKS------ 1002
EEL + ++ + F ++ V+ + E G D +Q N K + E ++
Sbjct: 768 EELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHM 827
Query: 1003 --NGKRDSFLAQTKNKKENMKPAAK--LKLESSSLKVKGEILLEEEKSTDFVFIPPEGKD 1058
K L + + + + +K K +SS +K E+ + ++ + + ++
Sbjct: 828 DFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQE------LQEKTRE 881
Query: 1059 AKERILTDHQ-KEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSK 1117
+ER+ Q KE L+ + + + + TL T+ Q+ E+ TLT++ K+D K
Sbjct: 882 VQERLNEMEQLKEQLENRDSTLQTVER-----EKTLITEKLQQTLEEVKTLTQE-KDDLK 935
Query: 1118 MM-----ITEEQMDSDIVIPQDVTEDC---------GMAEHLE-----KSSLSNNECGSL 1158
+ I +Q+ SDI ++ D + +H E KS +S +L
Sbjct: 936 QLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNL 995
Query: 1159 D------KTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSSSSVSNTTVAGTPP 1212
+T E KK + ++ T T A +N + + +
Sbjct: 996 HMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLI------ 1049
Query: 1213 YPTSRRQTFITLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTDFLPKAKQREGTF 1272
+ + LE +E NI +T++N +E + D L K +Q
Sbjct: 1050 --QEKNELQQMLESVI-AEKEQLKTDLKENIE--MTIENQEELRLLGDELKK-QQEIVAQ 1103
Query: 1273 SKSDSEKIVNGTKRSSRRAGKAEQTGNKRSKPLMRSEPEK-NTEESVEGIVVLENNPPGL 1331
K+ + K R+ R + E+ ++S+ L + + N +E + + N L
Sbjct: 1104 EKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENL 1163
Query: 1332 LNQTECVSDNQVHLSESTME------HDNTKLKAATVENAVLLETNTVEEKNVEINLESK 1385
N+ + H+ +E + ++K+ T E VL E +K+ E +
Sbjct: 1164 KNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKEL----QKSFETERDHL 1219
Query: 1386 ENTPPVVISADQMVNED---SQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQKKE 1442
+ + E+ + + + +Q+T+ R SE +QD E SH K +
Sbjct: 1220 RGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQ 1279
Query: 1443 RRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQN 1502
EE P+ LH + ++LP K ++E QE + E + T +++ A E
Sbjct: 1280 ----EEIPV----LHEEQELLPNVKEVSET--QETMNELELLTEQSTTKDSTTLARIEME 1329
Query: 1503 KKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEE 1562
+ + + + +S+ + ++ + K ++ + + + + ++ ++ +E
Sbjct: 1330 RLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETL-------AKIQES 1382
Query: 1563 GSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQ 1622
S++++S K K NE+ I + E+ ++ + E + + + E
Sbjct: 1383 QSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEI--------EMLGLSKRLQESH 1434
Query: 1623 DESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKR 1682
DE +V + DL ++ + L + ++ E K + +L T +K
Sbjct: 1435 DEMKSVAKEKD----DLQRLQEVLQSESDQLKENIK---------EIVAKHLETEEELKV 1481
Query: 1683 LHKRDSFDNCSLGESSKIGISDISSLSEKTFQ--TLECQHKRSRRVRRSKGCDCCGEKSQ 1740
H C L E + +LSEK + T++ Q + ++K + ++ Q
Sbjct: 1482 AH-------CCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQ 1534
Query: 1741 PQEKSLIGLKNTENNDVEISETKKADVQA--PVSPSETSQANPYSEGQFLDEHHSVNFHL 1798
K + ++ N + E +KA A + N E Q + +
Sbjct: 1535 FNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQ-----EEIQIMI 1589
Query: 1799 GLKEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNEN 1858
KE+ + ++L + + KENT +E + M ESQE +
Sbjct: 1590 KEKEEMKRVQEALQIERDQLKENT------------KEIVAKMK-------ESQEKEYQF 1630
Query: 1859 FKTVGPCLGDSKNVSQESLETKEEKPEETPKMELSLENVTVEG-NACKVTESNLEKAKTM 1917
K + N +QE + E E+ +L+LEN+ E ++ NLE+ +++
Sbjct: 1631 LKMT------AVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSV 1684
Query: 1918 ELNVGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSD 1977
+ER + ++EE + E D K N +E T + L
Sbjct: 1685 T-----------KER-----DDLRSVEETLK---VERDQLKENLRETITRDLEKQEEL-- 1723
Query: 1978 NTTPVKLNAQTEISEQTAAGELDGGNDVSDL-----HSSEETNTK-MKNNEEMMIGEAMA 2031
+ L E ++ + N++S++ HS++ + +K EE+ I
Sbjct: 1724 KIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHL 1783
Query: 2032 ETGHDGETENEGITT-KTSKPDEAETNM------LTAEMDNFVCDTVEMSTEEGIIDANK 2084
+ + + GI + KT K + ++ L ++ + ++ T + D N+
Sbjct: 1784 KEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKK--DVNE 1841
Query: 2085 TETNTEYSKSEEKLDNNQMVMESDILQEDHHTSQKVEE 2122
T+ + +K +Q + S + E+ + +QK+ E
Sbjct: 1842 TQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHE 1879
Score = 65.5 bits (158), Expect = 6e-10
Identities = 178/891 (19%), Positives = 337/891 (37%), Gaps = 126/891 (14%)
Query: 1300 KRSKPLMRSEPEKNTEESVEGIVVLENNPPGLLNQTECVSDNQVHLSESTMEHDNTKLKA 1359
K ++ + + EK+ + E I VL L N E VS+ Q ++E + + + K
Sbjct: 1261 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKE-VSETQETMNELELLTEQSTTKD 1319
Query: 1360 ATVENAVLLETNTVEEKNVEINLESKENTPPVVISADQMVNEDSQVQITPNQ------KT 1413
+T + +E + EK E S+E + D + +++ +Q +T
Sbjct: 1320 STTLARIEMERLRLNEKFQE----SQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRET 1375
Query: 1414 LRRSSRRRSEVVESTTESQDKENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAE-- 1471
L + +S+ E + ++K+N K E+ KP + L I+ ++L K + E
Sbjct: 1376 LAKIQESQSKQ-EQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESH 1434
Query: 1472 -------------QTLQENLIEKGSNLHEKTLGETSANAETEQNKKKADPENIKSEGDGT 1518
Q LQE L + L E + + ETE+ K A +K + +
Sbjct: 1435 DEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHC-CLKEQEETI 1493
Query: 1519 QDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWKNKSNE 1578
++ SEK T ++ + + ++N + E +E+ + K+
Sbjct: 1494 NELRVNLSEKETEIST---IQKQLEAINDKLQNKIQEIYEKEEQFNIKQ----------- 1539
Query: 1579 SVDIQDQEEKVVKQECIKAENQSHDYKATSEED--VSIKSPICEKQDESNTVICQDSTV- 1635
I + +EKV + + K ++ D S E + + + + E Q+E +I + +
Sbjct: 1540 ---ISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMK 1596
Query: 1636 -TSDLLQVP-DDLPNVCEE---KNETSKYAEYSFTSLPVPESNLRTRNAIKRLHKRDSFD 1690
+ LQ+ D L +E K + S+ EY F + I+ H ++ F
Sbjct: 1597 RVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIE--HLKEQF- 1653
Query: 1691 NCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQEKSLI--G 1748
E+ K+ + +I + + + Q L + R V + + E++ E+ +
Sbjct: 1654 -----ETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKEN 1708
Query: 1749 LKNTENNDVEISETKKADVQAPVSPSET---------SQANPYSEGQFLDEHHSVNF--- 1796
L+ T D+E E K ET + N S Q EH +
Sbjct: 1709 LRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQ 1768
Query: 1797 -----------HLGLKEDNDTINDSL--IVSETKSKENTMQESLPSGIVNFREEICDMDS 1843
H+ LKE +TI D L IVSE K + MQ+ L + +E+I ++ +
Sbjct: 1769 DLKIQEELRIAHMHLKEQQETI-DKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKA 1827
Query: 1844 SEAMSLESQESPNENFKTVGPCLGDSKNVSQESLETKEEKPEETPKMELSLENVTVEGNA 1903
+E + ++ NE K VS+ K+ K + +L +EN+ N
Sbjct: 1828 NEHQLITLKKDVNET----------QKKVSEMEQLKKQIKDQSLTLSKLEIENL----NL 1873
Query: 1904 CKVTESNLEKAKTMELNVGNEASFHGQERTKTGISEEAAIEENKRND---DSEADTAKLN 1960
+ NLE+ K++ N + + +E +++E K D E TA++
Sbjct: 1874 AQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKE-SLQETKARDLEIQQELKTARML 1932
Query: 1961 AKEVATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKMKN 2020
+KE +S+ T + ++I + + + + +L E ++K
Sbjct: 1933 SKEHKETVDKLREKISEKTIQI-----SDIQKDLDKSKDELQKKIQELQKKELQLLRVKE 1987
Query: 2021 NEEMMIGEAMAETGHDGETENEGITTKTSKPDEAET-NMLTAEMDNFVCDTVEMSTEEGI 2079
+ M H E E + K EA+ +M + MDNF + E I
Sbjct: 1988 DVNM---------SHKKINEME----QLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEI 2034
Query: 2080 IDANKTETNTEYSKSEEKLDNNQMVMESDILQEDHHTSQKVEEPSQCLASG 2130
K K K++ +Q + + + +V+ + L+ G
Sbjct: 2035 RIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDG 2085
Score = 38.1 bits (87), Expect = 0.11
Identities = 128/627 (20%), Positives = 253/627 (40%), Gaps = 74/627 (11%)
Query: 1275 SDSEKIVNGTKR-SSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEGIVVLENNPPGLLN 1333
S+ ++ VN K+ R K + SK L E +ES E I ++ +
Sbjct: 1541 SEVQEKVNELKQFKEHRKAKDSALQSIESKML---ELTNRLQESQEEIQIMIKEKEEMKR 1597
Query: 1334 QTECVSDNQVHLSESTMEHDNTKLKAATVENAVLLET--NTVEEKNVEINLESKENTPPV 1391
E + + L E+T E ++ E L T N +EK EI KE
Sbjct: 1598 VQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIE-HLKEQFETQ 1656
Query: 1392 VISADQMVNEDSQVQ--ITPNQKTLRRSSRRRSEV--VESTTE---SQDKENSHQKKERR 1444
++ + + E+ ++ + N + +R ++ R ++ VE T + Q KEN + R
Sbjct: 1657 KLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRD 1716
Query: 1445 KEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQNKK 1504
E+++ L+ +H+K+ KL + + N I SN+ +K L ++ + + K
Sbjct: 1717 LEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEI---SNM-QKDLEHSNDALKAQDLKI 1772
Query: 1505 KADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGS 1564
+ + Q+ +DK +RG +T + S + +ENS + E +E
Sbjct: 1773 QEELRIAHMHLKEQQETIDK-----LRGIVSEKTDKLS-NMQKDLENSNAKLQEKIQELK 1826
Query: 1565 RKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAE--NQSHDYKATSEEDVSIKSPICEKQ 1622
+ K D+ + ++KV + E +K + +QS E++++ + E
Sbjct: 1827 ANEHQLITLKK-----DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENL 1881
Query: 1623 DESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKR 1682
+E +V+ + +L +V + L ++ E+ + E L + + L+T + +
Sbjct: 1882 EEMKSVMKE----RDNLRRVEETLKLERDQLKESLQ--ETKARDLEI-QQELKTARMLSK 1934
Query: 1683 LHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQ 1742
HK ++ D +SEKT Q + Q + + +SK D +K Q
Sbjct: 1935 EHK-ETVDKLR------------EKISEKTIQISDIQ----KDLDKSK--DELQKKIQEL 1975
Query: 1743 EKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGLKE 1802
+K + L + DV +S K ++ E + ++ + NF L K+
Sbjct: 1976 QKKELQLLRVK-EDVNMSHKK-------INEMEQLKKQFEAQNLSMQSVRMDNFQL-TKK 2026
Query: 1803 DNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTV 1862
++++ + IV++ + + ++ESL F + +M +++ N K
Sbjct: 2027 LHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREM--------IARDRQNHQVKPE 2078
Query: 1863 GPCLGDSKNVSQESLETKEEKPEETPK 1889
L D + ESL K + +E K
Sbjct: 2079 KRLLSDGQQHLTESLREKCSRIKELLK 2105
Score = 33.5 bits (75), Expect = 2.7
Identities = 83/418 (19%), Positives = 169/418 (40%), Gaps = 26/418 (6%)
Query: 1743 EKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGLKE 1802
EK + LK E ND++ E + + E + S + L +H V ++ L
Sbjct: 520 EKEEMELKLKEKNDLDEFEALERKTK---KDQEMQLIHEISNLKNLVKHAEV-YNQDL-- 573
Query: 1803 DNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTV 1862
+N+ + ++ E + + +QE + S + E MD S SLES E P + +T+
Sbjct: 574 ENELSSKVELLREKEDQIKKLQEYIDSQ----KLENIKMDLS--YSLESIEDPKQMKQTL 627
Query: 1863 GPCLGDSKNVSQESLETKEEKPEETPKMELSLENVTVEGNACKVTESNLEKAKTMELNVG 1922
+ + +ES + E E KM+ N ++ +S LE K M++++
Sbjct: 628 FDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLE 687
Query: 1923 NEASFHGQERTK-TGISEEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTTP 1981
E E TK T + + ++ N + E L KE+ E ++ +
Sbjct: 688 KELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQ-KELNKEVEENEALREEVILL 746
Query: 1982 VKLNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKMKNNEEMMIGEAMAETGHDGETEN 2041
+L + E+ D ++ + S ++ ++E + + E G+T++
Sbjct: 747 SELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEI---GKTKD 803
Query: 2042 EGITTKTS--KPDEAETNMLTAEMDNFVCDTVEMSTEEGIIDANKTETNTEYSKSEEKLD 2099
+ TT+++ D+ N T MD +M EE + + SK +K D
Sbjct: 804 DLATTQSNYKSTDQEFQNFKTLHMD--FEQKYKMVLEE---NERMNQEIVNLSKEAQKFD 858
Query: 2100 NNQMVMESDILQEDHHTSQKVEEPSQCLASGTAISELIIEDNNASPQKLRELDPSLVS 2157
++ +++++ + +K E + L + E + +N S + E + +L++
Sbjct: 859 SSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQL--ENRDSTLQTVEREKTLIT 914
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 68.6 bits (166), Expect = 7e-11
Identities = 234/1282 (18%), Positives = 484/1282 (37%), Gaps = 163/1282 (12%)
Query: 987 ENSQLNVKISGMERKSNGKRDSFLAQTKNKKENMKPAAKLKLESSSLKVKGEILLEEEKS 1046
EN +L ++ + ++ L+ + KE ++ ++K+E +L K + L+ E+ S
Sbjct: 1695 ENDRLRAEVHPAGDTAKECMETLLSSNASMKEELE---RVKMEYETLSKKFQSLMSEKDS 1751
Query: 1047 TDFVFIPPEGKDAKERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEPMEIP 1106
+ E +D K +I + V K + ++N T ++E IP
Sbjct: 1752 -----LSEEVQDLKHQI----EGNVSKQANLEATEKHDNQ--------TNVTEEGTQSIP 1794
Query: 1107 TLTRKPKEDSKMMITEEQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNECGSLDKTSP--- 1163
T + +DS M T + P + + +++ NN +D+
Sbjct: 1795 GETEE--QDSLSMSTRPTCSESV--PSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIA 1850
Query: 1164 --EMSNSNNDERKKALISSRKTSTECASSTENSFVVSSSSVSNTTVAGTPPYPTSRRQTF 1221
E N E + L + + T S+ + + V+ + R T
Sbjct: 1851 GLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTK 1910
Query: 1222 I---TLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTDFLP-KAKQREGTFSKSDS 1277
+ E+ D E R + N S ++ + IK + L + K + S+ +
Sbjct: 1911 LKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEE 1970
Query: 1278 EKIVNGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEGIVVLENNPPGLLNQTEC 1337
EK +Q +++K + SE K E ++G N E
Sbjct: 1971 EK---------------QQLVKEKTK--VESEIRKEYLEKIQGAQKEPGNKSHAKELQEL 2013
Query: 1338 VSDNQVHLSESTMEHDNTKLKAATVENAV--LLETNTVEEKNVEINLESKENTPPVV--- 1392
+ + Q + + + + K + +E V L T +K++EI +KEN V
Sbjct: 2014 LKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEI---TKENLAQAVEHR 2070
Query: 1393 ------ISADQMVNEDSQ---VQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQKKER 1443
+++ +++ +D+Q ++ + L++ + E V+S + +D++ +++
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDL--ERRLE 2128
Query: 1444 RKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQNK 1503
+ EE+ +K + K D L ++K+ E+T+ E I+ N +K + + N ++ +
Sbjct: 2129 QAEEKHLKEKKNMQEKLDALRREKVHLEETIGE--IQVTLNKKDKEVQQLQENLDSTVTQ 2186
Query: 1504 KKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRAS--------QGLLSSIENSESD 1555
A +++ S D ++D++ + + Q++ L +
Sbjct: 2187 LAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIH 2246
Query: 1556 SSEAKEEGSRKKRSGK-WKNKSNESVDIQ----DQEEKVVKQECIKAENQSHDYKATSEE 1610
E K SR + + W++K+ V +Q D + K+ + E H Y ++ E
Sbjct: 2247 MEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNE 2306
Query: 1611 DVSIKSPICEKQDE----SNTV-IC--QDSTVTSDLLQVPDDLPN--VCEEKNETSKYAE 1661
++S + +D+ SN++ C Q + + Q D+ N E+ ET A
Sbjct: 2307 LAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQAS 2366
Query: 1662 YSFTSLPVPESNLRTRNAIKRLHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLE---C 1718
TS E N++ + I L ++ E+ ++ I+++ +K + LE
Sbjct: 2367 RELTSRLHEEINMKEQKIISLLSGKE--------EAIQVAIAELRQQHDKEIKELENLLS 2418
Query: 1719 QHKRSRRVRRSKGCDCCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQ 1778
Q + V + + +Q E LK + +++ + V++ +S + +
Sbjct: 2419 QEEEENIVLEEENKKAVDKTNQLMET----LKTIKKENIQQKAQLDSFVKS-MSSLQNDR 2473
Query: 1779 ANPYSEGQFLDEHHSVNFHLGLKEDNDTINDSLIVSETKSKE------------NTMQES 1826
+ Q L+E HL + + D + K KE N+
Sbjct: 2474 DRIVGDYQQLEER-----HLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAK 2528
Query: 1827 LPSGIVNFREEICDM----DSSEAMSLESQESPNENFKTVGPCLGDSKNVSQESLETKEE 1882
L + ++ +RE++ + DS + LE Q N+ + L + +ES E E+
Sbjct: 2529 LDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEK---LKESEEANED 2585
Query: 1883 KPEETPKMELSLENVTVEGNACKVTESNLEKAKTMELNVGNEASFHGQERTK-TGISEEA 1941
++ ++++ E + KV+ S L + T G +H Q + K + +
Sbjct: 2586 LRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLS 2645
Query: 1942 AIEENKRNDDSEAD-----TAKLNAKEVA--TEEFNSDISLSDNTTPVKLNAQTEISEQT 1994
A+ + + +E + K AK+V ++ ++ + + N +TE +E+
Sbjct: 2646 ALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRN-ETETAEER 2704
Query: 1995 AAGELDGGNDVSDLHSSEETNTKMKNNEEMMI---GEAMAETGHDGETENEGITTKTSKP 2051
A + D+ ++ TK I G +M+ + + NE + K
Sbjct: 2705 VA---ELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKY 2761
Query: 2052 DEAETNMLTAEMDNFVCDTVEMSTEEGIIDANKTETNTEYSKSEEKLDNNQMVMESDILQ 2111
D + + + + + E N TE N+ EKL+ + + +L
Sbjct: 2762 DASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENS--LSHLEKLNQQLLSKDEQLL- 2818
Query: 2112 EDHHTSQKVEEPSQCLASGTAISELIIEDNNASPQKLRELDPSLVSANDSPSGMQTRCVW 2171
H +SQ + +Q + A++ L E ++ L L S G Q R
Sbjct: 2819 --HLSSQLEDSYNQVQSFSKAMASLQNERDH--------LWNELEKFRKSEEGKQ-RSAA 2867
Query: 2172 SPLASPS-TSILKRGLKRSQED 2192
P SP+ LK+ + Q D
Sbjct: 2868 QPSTSPAEVQSLKKAMSSLQND 2889
Score = 53.1 bits (126), Expect = 3e-06
Identities = 178/969 (18%), Positives = 362/969 (37%), Gaps = 156/969 (16%)
Query: 1250 KNNQETMIKTDFLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRSKPLMRSE 1309
K + ET+ +T + E +FS ++ +N K S G +T ++ L R+E
Sbjct: 886 KRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFS---LGVEIKTLKEQLNLLSRAE 942
Query: 1310 PEKN--TEESVEGIVVLENN-----PPGLLNQTECVSDNQVHLSESTMEHDNTKLKAATV 1362
K EE E L+ N P G +++ E ++ L + E KL+AA +
Sbjct: 943 EAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEEL--QHEFDLLKKENEQRKRKLQAALI 1000
Query: 1363 ENAVLLE-TNTVEEKNVEINLESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRR 1421
LL+ + +EE+ + ESK+ P ++ ++ +
Sbjct: 1001 NRKELLQRVSRLEEELANLKDESKKEIP-----------------LSETERGEVEEDKEN 1043
Query: 1422 SEVVESTTESQDKENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEK 1481
E E S+ +E K+ E+E LQ HI+ D+ ++KL AE+ Q + +
Sbjct: 1044 KEYSEKCVTSKCQEIEIYLKQTISEKEVELQ----HIRKDL--EEKLAAEEQFQALVKQM 1097
Query: 1482 GSNLHEKTLGETSANAETEQN----KKKADPENIKSEGDGTQDI---------------- 1521
L +KT AE +N +K S+GD +
Sbjct: 1098 NQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEH 1157
Query: 1522 -----------VDKSSEKLVRGRTRYQTRRASQGLLSSIENSE----SDSSEAKEEGSRK 1566
++K E+L + T R + +L + E + + K++ +R
Sbjct: 1158 WKPELEEKILALEKEKEQLQKKLQEALTSR--KAILKKAQEKERHLREELKQQKDDYNRL 1215
Query: 1567 KRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDESN 1626
+ ++K NE++ Q ++ ++ +E I + S D + + ++ P+ + ++ +
Sbjct: 1216 QEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHH 1275
Query: 1627 TVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKRLHKR 1686
T +S N+C + S+ A V + IK K
Sbjct: 1276 TQPVLES--------------NLCPDWPSHSEDASALQGGTSVAQ--------IKAQLKE 1313
Query: 1687 DSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSK--------GCDCCGEK 1738
+ L S+++ SE+ FQ E +K+ + K + +K
Sbjct: 1314 IEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQK 1373
Query: 1739 SQPQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSV-NFH 1797
+ + + GL++ ++ E +K +S E + Y GQ ++ ++
Sbjct: 1374 LESSQLQIAGLEHLRELQPKLDELQKL-----ISKKEEDVS--YLSGQLSEKEAALTKIQ 1426
Query: 1798 LGLKEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNE 1857
+ E D I E ++KE+ + I + E+C+M E + +
Sbjct: 1427 TEIIEQEDLIKALHTQLEMQAKEHDER------IKQLQVELCEMKQKPEEIGEESRAKQQ 1480
Query: 1858 NFKTVGPCLGDSKNVSQESLETKEEKPEETPKMELSLENVTVEGNACKVTESNLEKAKTM 1917
+ + L K +E+ +E ELSL T+E ++T+S +
Sbjct: 1481 IQRKLQAALISRKEALKENKSLQE---------ELSLARGTIE----RLTKSLAD----- 1522
Query: 1918 ELNVGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSD 1977
V ++ S +E+ T + A ++E + +E D + L N +S S
Sbjct: 1523 ---VESQVSAQNKEK-DTVLGRLALLQEERDKLITEMDRSLLE---------NQSLSSSC 1569
Query: 1978 NTTPVKLNAQTEISEQTAAGELDG--GNDVSDLHSSEETNTKMKNNEEMMIGEAMAETGH 2035
+ + L TE E+ E++ + +++ +E + +++ E+++ ++ +
Sbjct: 1570 ESLKLALEGLTEDKEKLVK-EIESLKSSKIAESTEWQEKHKELQKEYEILL-QSYENVSN 1627
Query: 2036 DGETENEGITTKTSKPDEAETNMLTAEMDNFVCDTVEMSTEEGIIDANKTETNTEYSKSE 2095
+ E + + E + + E + + E+ + + + SK +
Sbjct: 1628 EAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQ 1687
Query: 2096 EKLDNNQMVMESDILQ-EDHHTSQKVEEPSQCLASGTAISELIIEDNNASPQKLRELDPS 2154
+ L+ + E+D L+ E H +E + L S A + +E + L + S
Sbjct: 1688 KILELEE---ENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQS 1744
Query: 2155 LVSANDSPS 2163
L+S DS S
Sbjct: 1745 LMSEKDSLS 1753
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 67.4 bits (163), Expect = 2e-10
Identities = 172/952 (18%), Positives = 356/952 (37%), Gaps = 125/952 (13%)
Query: 1254 ETMIKTDFLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRS-----KPLMRS 1308
E +IK+ L +AK +E T + + E+ +N + +R + + + KR L +
Sbjct: 910 EGLIKSKILLEAKVKELT-ERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKV 968
Query: 1309 EPEKNTEESV-----EGIVVLENNPPGLLNQTECVSD-NQVHLSESTMEHDNT----KLK 1358
E EK+ E+ E + LE N L + + + + +Q L + +E D K+
Sbjct: 969 EKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKIN 1028
Query: 1359 AATVENAVLLETNTVEEKNVEINLESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSS 1418
A + LE + +EK + +LE + + D ++++S + + +++ +
Sbjct: 1029 AKLEQQTDDLEGSLEQEKKLRADLERAKRK----LEGDLKMSQESIMDLENDKQQIEEKL 1084
Query: 1419 RRRSEVVESTTESQDKENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENL 1478
+++ + D E H + ++K +E + L ++++ AE TL+ +
Sbjct: 1085 KKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEEL--------EEEIEAEHTLRAKI 1136
Query: 1479 IEKGSNLHEKTLGETSANAETEQNKKKADPE-NIKSEGDGTQDIVDKSSEKLVRGRTRYQ 1537
++ S+L + L E S E A E N K E + + D L T
Sbjct: 1137 EKQRSDL-ARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAT 1195
Query: 1538 TRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK-NKSNESVDIQDQEEKVVKQECIK 1596
R+ ++ + + K++ ++K K + + +++ + + +++ C
Sbjct: 1196 LRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRT 1255
Query: 1597 AENQSHDYKATSEEDVSI--------------KSPICEKQDESNTVICQDSTVTSDLLQV 1642
E+Q + KA E+ + + + +E ++I Q + L Q
Sbjct: 1256 VEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQ 1315
Query: 1643 PDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKRLHKRDSFDNCSLGESSKIGI 1702
++L EE+ + ++ +S+ + ++ ++ + L +
Sbjct: 1316 LEELKRQMEEETKAKNAMAHAL------QSSRHDCDLLREQYEEEQEAKAELQRALSKAN 1369
Query: 1703 SDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQEKSLIGLKNTENNDVEISET 1762
S+++ K ++T Q + K ++ Q E++ T N+ E
Sbjct: 1370 SEVAQWRTK-YETDAIQRTEELEEAKKK----LAQRLQEAEENT----ETANSKCASLEK 1420
Query: 1763 KKADVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGLKEDNDTINDSLIVSETKSKENT 1822
K +Q V ++ LD+ NF L E +++S E KE+
Sbjct: 1421 TKQRLQGEVEDLMRDLERSHTACATLDKKQR-NFDKVLAEWKQKLDESQAELEAAQKESR 1479
Query: 1823 MQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTVGPCLGDSKNVSQESLETKEE 1882
+ + N EE+ +D E + E++ E KN+ QE+ +TK+
Sbjct: 1480 SLSTELFKMRNAYEEV--VDQLETLRRENKNLQEEISDLTEQIAETGKNL-QEAEKTKKL 1536
Query: 1883 KPEETPKMELSLENVTVEGNACKVTESNLEKAKTMELNVGNEASFHGQERTKTGISEEAA 1942
+E ++++LE V E +LE ++ L V E S E + I ++
Sbjct: 1537 VEQEKSDLQVALEEV----------EGSLEHEESKILRVQLELSQVKSELDRKVIEKDEE 1586
Query: 1943 IEENKRNDDSEADTAK-----------------------LNAKEVATEEFNSDIS----- 1974
IE+ KRN A+ + LN E+ N ++
Sbjct: 1587 IEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKH 1646
Query: 1975 -------LSDNTTPV--KLNAQTEISEQTAAGELDGGNDVSDLHS-----SEETNTKMKN 2020
L D+ + L + ++ EQ A E G + +L + T+ +
Sbjct: 1647 LRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLS 1706
Query: 2021 NEEMMIGEAMAETGHDGETENEGITTKTSKPDEAETNMLTAEMDNFVCDT--VEMSTEEG 2078
+E++ + H T T K EA+ AE++N + ++ E ++
Sbjct: 1707 EQELLDASDRVQLLHSQNTS----LINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKA 1762
Query: 2079 IIDANKTETNTEYSKSEEKLDNNQMVMESDILQEDHHTSQKVEEPSQCLASG 2130
I DA E K E+ + M+ ++ Q +++E Q G
Sbjct: 1763 ITDA---AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKG 1811
Score = 49.3 bits (116), Expect = 5e-05
Identities = 61/288 (21%), Positives = 140/288 (48%), Gaps = 26/288 (9%)
Query: 1338 VSDNQVHLSESTMEHDNTKLKAATVE--NAVLLETNTVEEKNVEINLESKENTPPVVISA 1395
+ D+Q+HL ++ +++ K + A VE N +LLE E + +++ LE E T +S
Sbjct: 1654 LKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLE----ELEEMKVALEQTERTRR--LSE 1707
Query: 1396 DQMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQKKERRKEEEKPLQKSP 1455
++++ +VQ+ +Q T +++++ E + ++ + ENS Q+ +E+ K
Sbjct: 1708 QELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQA-EVENSIQESRNAEEKAKKAITDA 1766
Query: 1456 LHIKDDVLPKQKLIAE-QTLQENLIEKGSNLHEKTLGETSANAETEQNKKKADPENIKSE 1514
+ +++ +Q A + +++NL + +L + L E A K+ EN E
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR-LDEAEQLALKGGKKQIQKLENRVRE 1825
Query: 1515 GDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSES--------DSSEAKEEGSRK 1566
+ D+ K + ++G +Y+ R+ + + E+ ++ D +AK + S K
Sbjct: 1826 LENELDVEQKRGAEALKGAHKYE-RKVKEMTYQAEEDHKNILRLQDLVDKLQAKVK-SYK 1883
Query: 1567 KRSGKWKNKSNESVD----IQDQEEKVVKQECIKAENQSHDYKATSEE 1610
+++ + + ++N + +Q + E+ ++ I AE+Q + +A S +
Sbjct: 1884 RQAEEAEEQANTQLSRCRRVQHELEEAAERADI-AESQVNKLRAKSRD 1930
>gi|115334679 retinoblastoma-binding protein 1 isoform III [Homo
sapiens]
Length = 1188
Score = 67.0 bits (162), Expect = 2e-10
Identities = 165/824 (20%), Positives = 305/824 (37%), Gaps = 126/824 (15%)
Query: 1309 EPEKNTEESVEGIVVLENNPPGLLNQTECVSDNQVHL-SESTMEHDNTKLKAATVENAVL 1367
E +K+ EES+E + L+ P TE S+ + ++ S S E + +LK+ +
Sbjct: 419 EEKKDLEESMEEALKLDQEMP----LTEVKSEPEENIDSNSESEREEIELKSPRGRRRIA 474
Query: 1368 LETNTVEEKNVEINLESK---ENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEV 1424
+ N+++++ E E K +T + D E + ++ +K + ++ +
Sbjct: 475 RDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKK 534
Query: 1425 VESTTESQDKENSHQKKERRKEEEKPLQKSPLHIKDDVLP--------------KQKLIA 1470
E + + D+E +K + R+E E ++D+ P K + I
Sbjct: 535 QEDSDKDSDEEE--EKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIY 592
Query: 1471 EQTLQENLIEKGSNLH-----------------EKTLGETSANAETEQNKKKADPENIKS 1513
E +++ I+ G L+ ++ + ++ KKKA K+
Sbjct: 593 EASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKA-----KN 647
Query: 1514 EGDGTQDIV-DKSSEKLVRGRTRYQTRRASQGL--LSSIENSESDSSEAKEEGSRKKRSG 1570
+ D +D D+ +K RGR ++ +S LS NSE S + +
Sbjct: 648 KEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDS--ETEDA 705
Query: 1571 KWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDESNTVIC 1630
KN NE + ++D+ EK N++ + EE+ I + I ++ D +
Sbjct: 706 LEKNLINEELSLKDELEK----------NENLNDDKLDEENPKISAHILKENDRTQMQPL 755
Query: 1631 QDSTV-TSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLR---TRNAIKRLHKR 1686
+ + + Q+ N E+ E K AE S P+ R T++ + K
Sbjct: 756 ETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKS------PKGKGRRSKTKDLSLEIIKI 809
Query: 1687 DSFDNCSLGESSKIGIS--DISSLSEKTFQTL------EC------------QHKRSRRV 1726
SF G I ++SSL K F + +C Q +++
Sbjct: 810 SSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRKILGQSSPEKKI 869
Query: 1727 RRSKGCDCCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQ 1786
R G + SQ + IG + +N + E ++ + P +E++Q +
Sbjct: 870 RIENGMEMTNTVSQERTSDCIGSEGMKNLNFE-QHFERENEGMPSLIAESNQCIQQLTSE 928
Query: 1787 FLDEHHSVNFHLGLKEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEA 1846
D ++ LKED D + LI ET + L E++ ++SSE+
Sbjct: 929 RFDSPAEETVNIPLKEDEDAM--PLIGPETLVCHEVDLDDLDEKDKTSIEDVA-VESSES 985
Query: 1847 MSLES-----QESPNENFKTVGPCL---GDSKNVSQESLETKEEKPEETPKMELSLENVT 1898
SL S NF P +S++V ES T E E E +
Sbjct: 986 NSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDSIAEESQEGLCERES 1045
Query: 1899 VEGNACKVTESNLEKAKTMELNVGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAK 1958
G E+N+ + E+ GQ+R G S A ++ KR + AK
Sbjct: 1046 ANG-----FETNVASGTCSIIVQERESREKGQKRPSDGNSGLMA-KKQKRTPKRTSAAAK 1099
Query: 1959 LNAKEVATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKM 2018
E N L + + +++ E ++ + ++V+ + K
Sbjct: 1100 --------NEKNGTDELDNMNSTERISFLQEKLQEIRKYYMSLKSEVATI-DRRRKRLKK 1150
Query: 2019 KNNEEMMIGEAMAETGHDGETENEGITTKTSKPDEAETNMLTAE 2062
K+ E G +M+ D G++ +S P + N+L E
Sbjct: 1151 KDREVSHAGASMSSASSD-----TGMSPSSSSPPQ---NVLAVE 1186
Score = 42.7 bits (99), Expect = 0.004
Identities = 146/714 (20%), Positives = 276/714 (38%), Gaps = 102/714 (14%)
Query: 1110 RKPKEDSKMMITEEQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNECGSLDKTSP----EM 1165
+K E+ K TE+++ + +DV +D AE E L + K E
Sbjct: 481 KKEIEEEK---TEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQED 537
Query: 1166 SNSNNDERKKALISSRKTSTECASSTENSFVVSSSSVSNTTVAGTPPYPTSRRQTF---- 1221
S+ ++DE ++ +T ++C S E ++ T V Y + Q
Sbjct: 538 SDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVK--VKYGRGKTQKIYEAS 595
Query: 1222 ITLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTDFLPKAKQREGTFSKSDSEKIV 1281
I + D E N+ VK ++ PK KQ++ +K DSEK
Sbjct: 596 IKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEK-- 653
Query: 1282 NGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEGIVVLENNPPGLLNQTECVSDN 1341
KR E+ +KR +P ++S L +N P L++T N
Sbjct: 654 -DEKRDE------ERQKSKRGRPPLKS--------------TLSSNMPYGLSKTA----N 688
Query: 1342 QVHLSESTMEHDNTKLKAATVENAVLLETNTV-EEKNVEINLESKENTPPVVISADQMVN 1400
S+S T E+A LE N + EE +++ LE EN ++ D++
Sbjct: 689 SEGKSDSCSSDSET-------EDA--LEKNLINEELSLKDELEKNEN-----LNDDKLDE 734
Query: 1401 EDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSH------QKKERRKEEEKPLQKS 1454
E+ ++ + L+ + R + + +E T + + EN K E+ +E +K +KS
Sbjct: 735 ENPKI----SAHILKENDRTQMQPLE-TLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKS 789
Query: 1455 PLHIKDDVLPKQKLIAEQTLQENL-IEKGSNLHEKTLGETSANAETEQNKKKADPENIKS 1513
PK K +T +L I K S+ + G D +N S
Sbjct: 790 ---------PKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSS 840
Query: 1514 --EGDGTQDIVDKSSEKLVRGRTRYQTR-RASQGL-LSSIENSESDSSEAKEEGSRKKRS 1569
E + Q + +K ++ + G++ + + R G+ +++ + E S EG +
Sbjct: 841 ATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNF 900
Query: 1570 GKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDE----- 1624
+ + NE + E +CI+ + S + + +EE V+I P+ E +D
Sbjct: 901 EQHFERENEGMPSLIAE----SNQCIQ-QLTSERFDSPAEETVNI--PLKEDEDAMPLIG 953
Query: 1625 SNTVICQDSTVTSDLLQVPD--DLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKR 1682
T++C + V D L D + +V E +E++ PV + N + +
Sbjct: 954 PETLVCHE--VDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPL-- 1009
Query: 1683 LHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQ 1742
++ S+ S I I ++ S++E++ + L C+ + + + C Q +
Sbjct: 1010 --TLSQDESRSVKSESDITI-EVDSIAEESQEGL-CERESANGFETNVASGTCSIIVQER 1065
Query: 1743 EKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVNF 1796
E G K + + + K+ S + ++ N E ++ ++F
Sbjct: 1066 ESREKGQKRPSDGNSGLMAKKQKRTPKRTSAAAKNEKNGTDELDNMNSTERISF 1119
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 64.3 bits (155), Expect = 1e-09
Identities = 162/802 (20%), Positives = 313/802 (39%), Gaps = 105/802 (13%)
Query: 981 PYSDGTENS---QLNVKISGMERKSNGKRDSFLAQTKN-KKENMKPAAKLKLESSSLKVK 1036
P +D T++S Q + KI+G RK++ K +TK K+E +K ++S L K
Sbjct: 1033 PKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTK 1092
Query: 1037 GEILLEEEKSTDFVFIPPEGKDAKERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQ 1096
E+ K + P + K K + T+ +K V K D + + + T +
Sbjct: 1093 E----EKAKKPNEKNKPLDNKGEKRKRKTE-EKGVDK----DFESSSMKISKLEVTEIVK 1143
Query: 1097 YSQEEPMEIPT--LTRKPKEDSKMMITEEQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNE 1154
S + ME T + R P++D I+ I + ++ + G E++ + + +
Sbjct: 1144 PSPKRKMEPDTEKMDRTPEKDK---ISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEK 1200
Query: 1155 CGSLDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSSSSVSNTTVAGTPPYP 1214
L+ TS ++ E+ K + + T TE +SST + S+SS + V +
Sbjct: 1201 ---LESTSSKV----KQEKVKGKVRRKVTGTEGSSSTLVDY-TSTSSTGGSPVRKSEEKT 1252
Query: 1215 TSRRQTFITLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTDFLPKAKQREGTFSK 1274
++R T+E+++ P E +I +P++K + F
Sbjct: 1253 DTKRTVIKTMEEYNNDNTAP------------------AEDVIIMIQVPQSKWDKDDFES 1294
Query: 1275 SDSEKIVNGTKRSSRRAGKAEQTGNKRSKPL-MRSEPEKNTEESVEGIVVLENNPPGLLN 1333
+ + V T+ S A N +KP + PEK +E S + +
Sbjct: 1295 EEED--VKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEK-----------IQK 1341
Query: 1334 QTECVSDNQVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVEINLESKENTPPVVI 1393
T+ VS + + ++ + K T + + + +E++N E + K +T P
Sbjct: 1342 FTKDVSHEIIQHEVKSSKNSASSEKGKTKDR----DYSVLEKENPE---KRKNSTQPEKE 1394
Query: 1394 SADQMVNEDSQVQ-ITPNQKTLRRSSRRRSEVVEST---TESQDKENSHQKKE----RRK 1445
S +NE + ++ + K R S + S S T ++DK+ + +E +R+
Sbjct: 1395 SNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRR 1454
Query: 1446 EEEKPLQK---SPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQN 1502
+E+ L + SP KD ++ E + +L +KG+ +K+ S + + +
Sbjct: 1455 DEKNELTRRKDSPSRNKDSASGQKNKPRE---ERDLPKKGTGDSKKSNSSPSRDRKPHDH 1511
Query: 1503 KKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEE 1562
K D + E K EK V R + LL + E+ + +
Sbjct: 1512 KATYDTKRPNEETKSVDKNPCKDREKHVL-EARNNKESSGNKLLYILNPPETQVEKEQIT 1570
Query: 1563 GSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQ 1622
G K + K K + + S + + + + + D SE +VS+ K+
Sbjct: 1571 GQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESD----SESNVSV------KE 1620
Query: 1623 DESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKR 1682
+ES+ I +D + D + +E +T+ + + +S+ + R
Sbjct: 1621 EESSGNISKD---------LKDKIVEKAKESLDTAAVVQVGISR---NQSHSSPSVSPSR 1668
Query: 1683 LHKRDSFDNCSLGESSKIGIS-DISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQP 1741
H S S+ S D +K + +HK+ ++ ++ G + EKSQ
Sbjct: 1669 SHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQK 1728
Query: 1742 QEKSLIGLKNTENNDVEISETK 1763
+ K+ +N D E + K
Sbjct: 1729 HKHK--KKKSKKNKDKEKEKEK 1748
Score = 49.7 bits (117), Expect = 4e-05
Identities = 167/889 (18%), Positives = 342/889 (38%), Gaps = 111/889 (12%)
Query: 1351 EHDNTKLKAATVENAVLLETNTVEEKNVEINL--ESKENTPPVVISADQMVNEDSQVQIT 1408
+ DNTK K ENA +K+ + ES+ P ++ + E + V+
Sbjct: 876 QKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEEN 935
Query: 1409 PNQKTLRRSSRRRSEVVESTTESQDKEN----SHQKKERRKEEEKPLQKSPLHIKDDVLP 1464
SR + V E D E+ S +K++R E +KP K D
Sbjct: 936 KTDSLFVLPSRDDATPVRD--EPMDAESITFKSVSEKDKR-ERDKPKAKG------DKTK 986
Query: 1465 KQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQNKKKADPENIKSEGDGTQDIVDK 1524
++ + + +EN+++ EK GE + +E KKA E K+ D T+
Sbjct: 987 RKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKT--DNTKSSSSS 1044
Query: 1525 SSEKLVRGRTRYQTRRASQGLLSS----IENSESDSSE--AKEEGSRKKRSGKWKNKSNE 1578
++ + G R ++++ + E + D S+ E+ + K+ K N+ N+
Sbjct: 1045 QKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNK 1104
Query: 1579 SVDIQDQEEK-VVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDESNTVICQDSTVTS 1637
+D + ++ K +++ + + +S K + E I P +++ E +T D T
Sbjct: 1105 PLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTE-KMDRTPEK 1163
Query: 1638 DLLQVPDDLPNVCEEKNETSKY--AEYSFTSLPVPESNLRTRNAIKRLHK-----RDSFD 1690
D + + + + ET K + + ++ P L + ++ + K R
Sbjct: 1164 DKISLSAPAKKI-KLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVT 1222
Query: 1691 NCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQEKSLIGLK 1750
S+ + + SS + E + R V ++ + + + P E +I ++
Sbjct: 1223 GTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTME-EYNNDNTAPAEDVIIMIQ 1281
Query: 1751 NTENN-DVEISETKKADVQA---------PVSPSETSQANPYSEGQFLDEHHSVNFHLGL 1800
++ D + E+++ DV++ P S + P + ++ ++ + +
Sbjct: 1282 VPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEK--I 1339
Query: 1801 KEDNDTINDSLIVSETKSKENTMQESLPSGIVNFRE-EICDMDSSEAMSLESQESPNENF 1859
++ ++ +I E KS +N+ S G R+ + + ++ E +Q N
Sbjct: 1340 QKFTKDVSHEIIQHEVKSSKNS--ASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNL 1397
Query: 1860 KTVGPCLGDSKNVSQESLETKEEKPEE----------TPKMELSLENVTVEGNACKVTES 1909
+ G+ K++SQ S E + + TP + + T E ++ K +
Sbjct: 1398 DRLNE-QGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDE 1456
Query: 1910 NLEKAKTMELNVGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEF 1969
E + + N+ S GQ+ EE D+ K N+ +
Sbjct: 1457 KNELTRRKDSPSRNKDSASGQKNKPR--------EERDLPKKGTGDSKKSNSSPSRDRKP 1508
Query: 1970 NSDISLSDNTTPVKLNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKMKNNEEMMIGEA 2029
+ + D P +E+T + + + D + H E N K + +++
Sbjct: 1509 HDHKATYDTKRP---------NEETKSVDKNPCKD-REKHVLEARNNKESSGNKLLYILN 1558
Query: 2030 MAETGHDGETENEGIT------TKTSKPDEAETNMLTAEMDNFVCDTVEMSTEEGIIDAN 2083
ET + E E IT T KP + ++ L++++ +T E + E D N
Sbjct: 1559 PPET----QVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTR---ETDEAAFEP---DYN 1608
Query: 2084 KTETNTEYSKSEEKLDNNQMVMESDILQEDHHTSQKVEEPSQCLASGTAISELIIEDNNA 2143
++++ + S EE+ N + D+ K+ E ++ A+ ++ I N +
Sbjct: 1609 ESDSESNVSVKEEESSGN---ISKDL-------KDKIVEKAKESLDTAAVVQVGISRNQS 1658
Query: 2144 SPQKLRELDPSL-VSANDSPSGMQTRCVWSPLASPSTSILKRGLKRSQE 2191
PS+ S + SPSG QTR S +S + K+ K+ ++
Sbjct: 1659 ------HSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEK 1701
Score = 37.0 bits (84), Expect = 0.24
Identities = 126/677 (18%), Positives = 249/677 (36%), Gaps = 89/677 (13%)
Query: 1445 KEEEKPLQKSPLHIKDDVLPK---QKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQ 1501
+E P + PL+I++ + + + Q+ + I GSN EK N +
Sbjct: 823 RENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNI--GSNYPEKLSARDGHNQKDNT 880
Query: 1502 NKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKE 1561
K+ + EN +G G + +++ RR E SE +
Sbjct: 881 KSKEKESENAPGDGKGNK-------------HKKHRKRRKG-------EESEGFLNPELL 920
Query: 1562 EGSRKKR--SGKWKNKSNESVDIQDQEEKV-VKQECIKAENQSHDYKATSEEDVSIK--- 1615
E SRK R +G +NK++ + +++ V+ E + AE S +K+ SE+D +
Sbjct: 921 ETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAE--SITFKSVSEKDKRERDKP 978
Query: 1616 -------------SPICEKQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEY 1662
S + +K++ V + + P P + + K ET K
Sbjct: 979 KAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNT 1038
Query: 1663 SFTSLPVPESNLRTRNAIKRLHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKR 1722
+S + + + ++ H + + ++ + + S K+ + + K
Sbjct: 1039 KSSS--SSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKA 1096
Query: 1723 SRRVRRSKGCDCCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPY 1782
+ ++K D GEK + + + K+ E++ ++IS K +V V PS + P
Sbjct: 1097 KKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKIS---KLEVTEIVKPSPKRKMEPD 1153
Query: 1783 SEG-QFLDEHHSVNFHLGLK------EDNDTINDSLIVSETKSKENTMQESLPSGIVNFR 1835
+E E ++ K E I + +S TK + ES S + +
Sbjct: 1154 TEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKL-ESTSSKVK--Q 1210
Query: 1836 EEICDMDSSEAMSLESQESPNENFKTVGPCLGDSKNVSQESLETK-------------EE 1882
E++ + E S ++ + G S+E +TK
Sbjct: 1211 EKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNT 1270
Query: 1883 KPEE-------TPKMELSLENVTVEGNACKVTE--SNLEKAKTMELNVGNEAS----FHG 1929
P E P+ + ++ E K T+ S++ K ++ NV + S +
Sbjct: 1271 APAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPE 1330
Query: 1930 QERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTTPVKLNAQTE 1989
+E + ++ + + E ++K +A + + D S+ + P K T+
Sbjct: 1331 KESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQ 1390
Query: 1990 ISEQTAAGEL-DGGNDVSDLHSSEETNTKMKNNEEMMIGEAMAETGHDGETENEGITTKT 2048
+++ L + GN S SS+E T K++ D +T+ + +
Sbjct: 1391 PEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSS 1450
Query: 2049 SKPDEAETNMLTAEMDN 2065
SK + E N LT D+
Sbjct: 1451 SKRRD-EKNELTRRKDS 1466
Score = 35.4 bits (80), Expect = 0.70
Identities = 80/392 (20%), Positives = 155/392 (39%), Gaps = 50/392 (12%)
Query: 1869 SKNVSQESLETKEEKPEETPKMELSLENVTVEGNACKVTESNLEKAKTMELNVGNEASFH 1928
SK+V E L TKEEK ++ + L+N + K KT E V +
Sbjct: 1081 SKDVKSEKLTTKEEKAKKPNEKNKPLDN-----------KGEKRKRKTEEKGVDKDFESS 1129
Query: 1929 GQERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTTPVKLNAQT 1988
+ +K ++E I + E DT K++ T E ISLS +KLN +T
Sbjct: 1130 SMKISKLEVTE---IVKPSPKRKMEPDTEKMD----RTPE-KDKISLSAPAKKIKLNRET 1181
Query: 1989 EISEQTAAGELDGGNDVSDLHSSEETNTKMKNNEEMMIGEAMAE-TGHDGETENEGITTK 2047
++ + E + N E T++K+K +E + G+ + TG +G + T
Sbjct: 1182 --GKKIGSTE-NISNTKEPSEKLESTSSKVK--QEKVKGKVRRKVTGTEGSSSTLVDYTS 1236
Query: 2048 TSKPDEAETNMLTAEMDNFVCDTVEMSTEEGIIDANKTETNTEYSKSEEKLDNNQMVMES 2107
TS + + D T+ +I + N + +E+ + Q V +S
Sbjct: 1237 TSSTGGSPVRKSEEKTD----------TKRTVIKTMEEYNNDNTAPAEDVIIMIQ-VPQS 1285
Query: 2108 DILQEDHHTSQKVEEPSQCLAS----GTAISELIIEDNNASPQKLRELDPSLVSANDSPS 2163
++D + ++ + +Q ++S + I + + +N +E +PS +
Sbjct: 1286 KWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKD 1345
Query: 2164 GMQTRCVWSPLASPSTSILKRGLKRSQEDEISSPVNKVRRVSFADPIYQAGLADDIDRRC 2223
+S +++ ++G + ++ + N +R + P ++ L DR
Sbjct: 1346 VSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNL----DR-- 1399
Query: 2224 SIVRSHSSNSSPIGKSVKTSPTTQSKHNTTSA 2255
+ N + +S K + T KH++T A
Sbjct: 1400 ---LNEQGNFKSLSQSSKEA-RTSDKHDSTRA 1427
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 64.3 bits (155), Expect = 1e-09
Identities = 162/802 (20%), Positives = 313/802 (39%), Gaps = 105/802 (13%)
Query: 981 PYSDGTENS---QLNVKISGMERKSNGKRDSFLAQTKN-KKENMKPAAKLKLESSSLKVK 1036
P +D T++S Q + KI+G RK++ K +TK K+E +K ++S L K
Sbjct: 1067 PKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTK 1126
Query: 1037 GEILLEEEKSTDFVFIPPEGKDAKERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQ 1096
E+ K + P + K K + T+ +K V K D + + + T +
Sbjct: 1127 E----EKAKKPNEKNKPLDNKGEKRKRKTE-EKGVDK----DFESSSMKISKLEVTEIVK 1177
Query: 1097 YSQEEPMEIPT--LTRKPKEDSKMMITEEQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNE 1154
S + ME T + R P++D I+ I + ++ + G E++ + + +
Sbjct: 1178 PSPKRKMEPDTEKMDRTPEKDK---ISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEK 1234
Query: 1155 CGSLDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSSSSVSNTTVAGTPPYP 1214
L+ TS ++ E+ K + + T TE +SST + S+SS + V +
Sbjct: 1235 ---LESTSSKV----KQEKVKGKVRRKVTGTEGSSSTLVDY-TSTSSTGGSPVRKSEEKT 1286
Query: 1215 TSRRQTFITLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTDFLPKAKQREGTFSK 1274
++R T+E+++ P E +I +P++K + F
Sbjct: 1287 DTKRTVIKTMEEYNNDNTAP------------------AEDVIIMIQVPQSKWDKDDFES 1328
Query: 1275 SDSEKIVNGTKRSSRRAGKAEQTGNKRSKPL-MRSEPEKNTEESVEGIVVLENNPPGLLN 1333
+ + V T+ S A N +KP + PEK +E S + +
Sbjct: 1329 EEED--VKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEK-----------IQK 1375
Query: 1334 QTECVSDNQVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVEINLESKENTPPVVI 1393
T+ VS + + ++ + K T + + + +E++N E + K +T P
Sbjct: 1376 FTKDVSHEIIQHEVKSSKNSASSEKGKTKDR----DYSVLEKENPE---KRKNSTQPEKE 1428
Query: 1394 SADQMVNEDSQVQ-ITPNQKTLRRSSRRRSEVVEST---TESQDKENSHQKKE----RRK 1445
S +NE + ++ + K R S + S S T ++DK+ + +E +R+
Sbjct: 1429 SNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRR 1488
Query: 1446 EEEKPLQK---SPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQN 1502
+E+ L + SP KD ++ E + +L +KG+ +K+ S + + +
Sbjct: 1489 DEKNELTRRKDSPSRNKDSASGQKNKPRE---ERDLPKKGTGDSKKSNSSPSRDRKPHDH 1545
Query: 1503 KKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEE 1562
K D + E K EK V R + LL + E+ + +
Sbjct: 1546 KATYDTKRPNEETKSVDKNPCKDREKHVL-EARNNKESSGNKLLYILNPPETQVEKEQIT 1604
Query: 1563 GSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQ 1622
G K + K K + + S + + + + + D SE +VS+ K+
Sbjct: 1605 GQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESD----SESNVSV------KE 1654
Query: 1623 DESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKR 1682
+ES+ I +D + D + +E +T+ + + +S+ + R
Sbjct: 1655 EESSGNISKD---------LKDKIVEKAKESLDTAAVVQVGISR---NQSHSSPSVSPSR 1702
Query: 1683 LHKRDSFDNCSLGESSKIGIS-DISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQP 1741
H S S+ S D +K + +HK+ ++ ++ G + EKSQ
Sbjct: 1703 SHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQK 1762
Query: 1742 QEKSLIGLKNTENNDVEISETK 1763
+ K+ +N D E + K
Sbjct: 1763 HKHK--KKKSKKNKDKEKEKEK 1782
Score = 49.7 bits (117), Expect = 4e-05
Identities = 167/889 (18%), Positives = 342/889 (38%), Gaps = 111/889 (12%)
Query: 1351 EHDNTKLKAATVENAVLLETNTVEEKNVEINL--ESKENTPPVVISADQMVNEDSQVQIT 1408
+ DNTK K ENA +K+ + ES+ P ++ + E + V+
Sbjct: 910 QKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEEN 969
Query: 1409 PNQKTLRRSSRRRSEVVESTTESQDKEN----SHQKKERRKEEEKPLQKSPLHIKDDVLP 1464
SR + V E D E+ S +K++R E +KP K D
Sbjct: 970 KTDSLFVLPSRDDATPVRD--EPMDAESITFKSVSEKDKR-ERDKPKAKG------DKTK 1020
Query: 1465 KQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQNKKKADPENIKSEGDGTQDIVDK 1524
++ + + +EN+++ EK GE + +E KKA E K+ D T+
Sbjct: 1021 RKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKT--DNTKSSSSS 1078
Query: 1525 SSEKLVRGRTRYQTRRASQGLLSS----IENSESDSSE--AKEEGSRKKRSGKWKNKSNE 1578
++ + G R ++++ + E + D S+ E+ + K+ K N+ N+
Sbjct: 1079 QKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNK 1138
Query: 1579 SVDIQDQEEK-VVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDESNTVICQDSTVTS 1637
+D + ++ K +++ + + +S K + E I P +++ E +T D T
Sbjct: 1139 PLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTE-KMDRTPEK 1197
Query: 1638 DLLQVPDDLPNVCEEKNETSKY--AEYSFTSLPVPESNLRTRNAIKRLHK-----RDSFD 1690
D + + + + ET K + + ++ P L + ++ + K R
Sbjct: 1198 DKISLSAPAKKI-KLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVT 1256
Query: 1691 NCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQEKSLIGLK 1750
S+ + + SS + E + R V ++ + + + P E +I ++
Sbjct: 1257 GTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTME-EYNNDNTAPAEDVIIMIQ 1315
Query: 1751 NTENN-DVEISETKKADVQA---------PVSPSETSQANPYSEGQFLDEHHSVNFHLGL 1800
++ D + E+++ DV++ P S + P + ++ ++ + +
Sbjct: 1316 VPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEK--I 1373
Query: 1801 KEDNDTINDSLIVSETKSKENTMQESLPSGIVNFRE-EICDMDSSEAMSLESQESPNENF 1859
++ ++ +I E KS +N+ S G R+ + + ++ E +Q N
Sbjct: 1374 QKFTKDVSHEIIQHEVKSSKNS--ASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNL 1431
Query: 1860 KTVGPCLGDSKNVSQESLETKEEKPEE----------TPKMELSLENVTVEGNACKVTES 1909
+ G+ K++SQ S E + + TP + + T E ++ K +
Sbjct: 1432 DRLNE-QGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDE 1490
Query: 1910 NLEKAKTMELNVGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEF 1969
E + + N+ S GQ+ EE D+ K N+ +
Sbjct: 1491 KNELTRRKDSPSRNKDSASGQKNKPR--------EERDLPKKGTGDSKKSNSSPSRDRKP 1542
Query: 1970 NSDISLSDNTTPVKLNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKMKNNEEMMIGEA 2029
+ + D P +E+T + + + D + H E N K + +++
Sbjct: 1543 HDHKATYDTKRP---------NEETKSVDKNPCKD-REKHVLEARNNKESSGNKLLYILN 1592
Query: 2030 MAETGHDGETENEGIT------TKTSKPDEAETNMLTAEMDNFVCDTVEMSTEEGIIDAN 2083
ET + E E IT T KP + ++ L++++ +T E + E D N
Sbjct: 1593 PPET----QVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTR---ETDEAAFEP---DYN 1642
Query: 2084 KTETNTEYSKSEEKLDNNQMVMESDILQEDHHTSQKVEEPSQCLASGTAISELIIEDNNA 2143
++++ + S EE+ N + D+ K+ E ++ A+ ++ I N +
Sbjct: 1643 ESDSESNVSVKEEESSGN---ISKDL-------KDKIVEKAKESLDTAAVVQVGISRNQS 1692
Query: 2144 SPQKLRELDPSL-VSANDSPSGMQTRCVWSPLASPSTSILKRGLKRSQE 2191
PS+ S + SPSG QTR S +S + K+ K+ ++
Sbjct: 1693 ------HSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEK 1735
Score = 37.0 bits (84), Expect = 0.24
Identities = 126/677 (18%), Positives = 249/677 (36%), Gaps = 89/677 (13%)
Query: 1445 KEEEKPLQKSPLHIKDDVLPK---QKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQ 1501
+E P + PL+I++ + + + Q+ + I GSN EK N +
Sbjct: 857 RENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNI--GSNYPEKLSARDGHNQKDNT 914
Query: 1502 NKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKE 1561
K+ + EN +G G + +++ RR E SE +
Sbjct: 915 KSKEKESENAPGDGKGNK-------------HKKHRKRRKG-------EESEGFLNPELL 954
Query: 1562 EGSRKKR--SGKWKNKSNESVDIQDQEEKV-VKQECIKAENQSHDYKATSEEDVSIK--- 1615
E SRK R +G +NK++ + +++ V+ E + AE S +K+ SE+D +
Sbjct: 955 ETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAE--SITFKSVSEKDKRERDKP 1012
Query: 1616 -------------SPICEKQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEY 1662
S + +K++ V + + P P + + K ET K
Sbjct: 1013 KAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNT 1072
Query: 1663 SFTSLPVPESNLRTRNAIKRLHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKR 1722
+S + + + ++ H + + ++ + + S K+ + + K
Sbjct: 1073 KSSS--SSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKA 1130
Query: 1723 SRRVRRSKGCDCCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPY 1782
+ ++K D GEK + + + K+ E++ ++IS K +V V PS + P
Sbjct: 1131 KKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKIS---KLEVTEIVKPSPKRKMEPD 1187
Query: 1783 SEG-QFLDEHHSVNFHLGLK------EDNDTINDSLIVSETKSKENTMQESLPSGIVNFR 1835
+E E ++ K E I + +S TK + ES S + +
Sbjct: 1188 TEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKL-ESTSSKVK--Q 1244
Query: 1836 EEICDMDSSEAMSLESQESPNENFKTVGPCLGDSKNVSQESLETK-------------EE 1882
E++ + E S ++ + G S+E +TK
Sbjct: 1245 EKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNT 1304
Query: 1883 KPEE-------TPKMELSLENVTVEGNACKVTE--SNLEKAKTMELNVGNEAS----FHG 1929
P E P+ + ++ E K T+ S++ K ++ NV + S +
Sbjct: 1305 APAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPE 1364
Query: 1930 QERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTTPVKLNAQTE 1989
+E + ++ + + E ++K +A + + D S+ + P K T+
Sbjct: 1365 KESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQ 1424
Query: 1990 ISEQTAAGEL-DGGNDVSDLHSSEETNTKMKNNEEMMIGEAMAETGHDGETENEGITTKT 2048
+++ L + GN S SS+E T K++ D +T+ + +
Sbjct: 1425 PEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSS 1484
Query: 2049 SKPDEAETNMLTAEMDN 2065
SK + E N LT D+
Sbjct: 1485 SKRRD-EKNELTRRKDS 1500
Score = 35.4 bits (80), Expect = 0.70
Identities = 80/392 (20%), Positives = 155/392 (39%), Gaps = 50/392 (12%)
Query: 1869 SKNVSQESLETKEEKPEETPKMELSLENVTVEGNACKVTESNLEKAKTMELNVGNEASFH 1928
SK+V E L TKEEK ++ + L+N + K KT E V +
Sbjct: 1115 SKDVKSEKLTTKEEKAKKPNEKNKPLDN-----------KGEKRKRKTEEKGVDKDFESS 1163
Query: 1929 GQERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTTPVKLNAQT 1988
+ +K ++E I + E DT K++ T E ISLS +KLN +T
Sbjct: 1164 SMKISKLEVTE---IVKPSPKRKMEPDTEKMD----RTPE-KDKISLSAPAKKIKLNRET 1215
Query: 1989 EISEQTAAGELDGGNDVSDLHSSEETNTKMKNNEEMMIGEAMAE-TGHDGETENEGITTK 2047
++ + E + N E T++K+K +E + G+ + TG +G + T
Sbjct: 1216 --GKKIGSTE-NISNTKEPSEKLESTSSKVK--QEKVKGKVRRKVTGTEGSSSTLVDYTS 1270
Query: 2048 TSKPDEAETNMLTAEMDNFVCDTVEMSTEEGIIDANKTETNTEYSKSEEKLDNNQMVMES 2107
TS + + D T+ +I + N + +E+ + Q V +S
Sbjct: 1271 TSSTGGSPVRKSEEKTD----------TKRTVIKTMEEYNNDNTAPAEDVIIMIQ-VPQS 1319
Query: 2108 DILQEDHHTSQKVEEPSQCLAS----GTAISELIIEDNNASPQKLRELDPSLVSANDSPS 2163
++D + ++ + +Q ++S + I + + +N +E +PS +
Sbjct: 1320 KWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKD 1379
Query: 2164 GMQTRCVWSPLASPSTSILKRGLKRSQEDEISSPVNKVRRVSFADPIYQAGLADDIDRRC 2223
+S +++ ++G + ++ + N +R + P ++ L DR
Sbjct: 1380 VSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNL----DR-- 1433
Query: 2224 SIVRSHSSNSSPIGKSVKTSPTTQSKHNTTSA 2255
+ N + +S K + T KH++T A
Sbjct: 1434 ---LNEQGNFKSLSQSSKEA-RTSDKHDSTRA 1461
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 62.8 bits (151), Expect = 4e-09
Identities = 89/440 (20%), Positives = 173/440 (39%), Gaps = 39/440 (8%)
Query: 1147 KSSLSNNECGSLDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSSSSVSNTT 1206
K S S++E + S +S + + + KK +S+KT+TE + N S ++
Sbjct: 173 KKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSND 232
Query: 1207 VAGTPPYPTSRRQTFITL--EKFDGSEN-----RPFSPSPLNNISSTVTVKNNQETMIKT 1259
S F+ L + D S N R +S + N S T ++T
Sbjct: 233 PISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNA 292
Query: 1260 DFLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVE 1319
A+ + +K DS+K+ K+ ++ + T + ++ + K+T++ +
Sbjct: 293 KKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKK 352
Query: 1320 GIVVLENNPPGLLNQTECVSDNQVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVE 1379
L + + D + + + E + K N K
Sbjct: 353 -----------KLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNL----------KKAS 391
Query: 1380 INLESKENTPPVVISAD---QMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKEN 1436
N + K++ + S D ++ +++SQ ++K + +++ + E +T++ D E
Sbjct: 392 KNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDA-DSEP 450
Query: 1437 SHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIE-KGSNLHEKTLGETSA 1495
K+ +K+E+K + S KDD K AE T E+ +E K H K E
Sbjct: 451 KGDSKKGKKDEKKGKKDSK---KDDKKKDAKKNAESTEMESDLELKKDKKHSK---EKKG 504
Query: 1496 NAETEQNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESD 1555
+ + + + D E+ +E D + K+S K+ T + G I+ S+
Sbjct: 505 SKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGT 564
Query: 1556 SSEAKEEGSRKKRSGKWKNK 1575
S+ +K EG KR + +K
Sbjct: 565 SANSKMEGLESKRGFRMSSK 584
Score = 47.8 bits (112), Expect = 1e-04
Identities = 78/384 (20%), Positives = 158/384 (41%), Gaps = 48/384 (12%)
Query: 1397 QMVNEDSQVQITPNQKTLRRS-----SRRRSEVVESTTESQDKE----NSHQKKERRKEE 1447
Q+V E ++ Q ++ L+ S S++ E+ ESQ+ + N QK ++ +
Sbjct: 146 QIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKN 205
Query: 1448 EKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQNKKKAD 1507
K LH K++ PK+ L +T + + E S E S N + ++D
Sbjct: 206 SKKTNTEFLHTKNN--PKKDLKRSKTSNDPISEICS--------ENSLNVDFLMLVGQSD 255
Query: 1508 PENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKK 1567
E+I + ++ +S+ T+Y + + S + DS +AK++ + K
Sbjct: 256 DESINFDA-WLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVK 314
Query: 1568 RSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDESNT 1627
++ K +D ++K VK++ + +S D K ++ K + + + +T
Sbjct: 315 KNVK-----------KDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDT 363
Query: 1628 VICQDSTVT--SDLLQVPDDLPNVCE-EKNETSKYAEYSFTSLPVPESNLRTRNAIKRLH 1684
+ST T D +D N+ + KN+ K T ES L ++ + K
Sbjct: 364 KKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKD-E 422
Query: 1685 KRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQEK 1744
K+D D+ + +K + + ++ + K + ++ K + S+ +K
Sbjct: 423 KKDKKDSKT---DNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGK------KDSKKDDK 473
Query: 1745 SLIGLKNTEN----NDVEISETKK 1764
KN E+ +D+E+ + KK
Sbjct: 474 KKDAKKNAESTEMESDLELKKDKK 497
>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
Length = 1094
Score = 60.8 bits (146), Expect = 2e-08
Identities = 126/654 (19%), Positives = 258/654 (39%), Gaps = 80/654 (12%)
Query: 1393 ISADQM-VNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQKKERRKEE---E 1448
+S++Q+ + +D +++ ++ + R E+ E E+Q +E + ERR +E E
Sbjct: 171 LSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELERE 230
Query: 1449 KPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQNKKKADP 1508
++ + + D L L ++ L++ E ++ HE + ETE+N+ + +
Sbjct: 231 MRTERELVERRQDQLGLMSLQLQEALKKQ--EAKADEHEGAIKNKLRQTETEKNQLEQEL 288
Query: 1509 E---NIKSEGDGTQDIVDKSSEKLVRGRTRYQ-TRRASQGLLSSIENSESDSSEAKEEGS 1564
E + ++ +G+++ + E+L T+ + R+ Q +S I +S+ + + E
Sbjct: 289 ELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDW 348
Query: 1565 RKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDE 1624
R +R E D++ Q + Q ++ A + E +K + K E
Sbjct: 349 RFRR-----GVEREKQDLEKQMSDLRVQ---------LNFSAMASELEEVKRCMERKDKE 394
Query: 1625 SNTVICQDSTVTSDL-------LQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTR 1677
+ Q +T +L LQ+ D L + + + + AE L + E
Sbjct: 395 KAHLASQVENLTRELENGEKQQLQMLDRLKEI--QNHFDTCEAERKHADLQISELTRHAE 452
Query: 1678 NAIKRLHK--RDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRR------- 1728
+A K+ + + + +L E ++ D+ ++++ + + +HK+ R
Sbjct: 453 DATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVD 512
Query: 1729 ---SKGCDCCGEKSQPQEKSLIGLKNTENNDVEISE--TKKADVQAPVSPSETSQANPYS 1783
K EK + + + L+ EN E+++ TK+A + + E + S
Sbjct: 513 ELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKS 572
Query: 1784 EGQFLDEHHSVNFHLGLKEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDS 1843
H + L +K DTI+ + SE K K++ +Q + + EEI ++
Sbjct: 573 --------HQADLELEVKNSLDTIH--RLESELK-KQSKIQSQMKVEKAHLEEEIAELKK 621
Query: 1844 SEAMSLESQESPNENFKTVGPCLGDSKNVSQESLETK--------------EEKPEETPK 1889
S+A E+ K + D N E K + + EET
Sbjct: 622 SQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETAT 681
Query: 1890 M--ELSLENVTVEGNACKVTESNLEKAKTM-ELNVGNEASFHGQERTKTGISEEAAIEEN 1946
+ +L LE V K S+L+ KT E N+ +E+++ E I
Sbjct: 682 IITQLKLER-DVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEA----ENHIRTL 736
Query: 1947 KRNDDSEADTAKLNAKEVATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGELD 2000
K E + AK++ ++ + D + T N + ++ Q +L+
Sbjct: 737 KAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLE 790
Score = 40.4 bits (93), Expect = 0.022
Identities = 134/688 (19%), Positives = 272/688 (39%), Gaps = 86/688 (12%)
Query: 1251 NNQETMIKTDFLPKAKQREGTFSKSDSE--KIVNGTKRSSRRAGKAEQTGNKRSKPLMRS 1308
++++ + DF + +R S+SD+E + + A K E ++ + L
Sbjct: 172 SSEQIRLGDDFNRELSRR----SRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQEL 227
Query: 1309 EPEKNTEESVEGIVVLENNPPGLLNQTECVSDNQVHLSESTMEHDNTKLKAATVENAV-- 1366
E E TE +V + GL++ + L E+ + + KA E A+
Sbjct: 228 EREMRTERE---LVERRQDQLGLMS---------LQLQEALKKQE---AKADEHEGAIKN 272
Query: 1367 -LLETNTVEEKNVEINLE-SKENTPPVVISADQMVN--EDSQVQITPNQKTLRRSSRRRS 1422
L +T T E+ +E LE S+ S + +++ E+ + Q+T + + + S
Sbjct: 273 KLRQTET-EKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVS 331
Query: 1423 EVVESTTESQDKENSHQKKERRKEEEKP---LQKSPLHIKDDVLPKQKLIAE--QTLQEN 1477
++ + + QD++ + R E EK Q S L ++ + + E + ++
Sbjct: 332 QISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERK 391
Query: 1478 LIEKGSNLHE-KTLGETSANAETEQNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRY 1536
EK + + L N E +Q + + I++ D T + K ++ + TR+
Sbjct: 392 DKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFD-TCEAERKHADLQISELTRH 450
Query: 1537 --QTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGK-----WK----------NKSNES 1579
+ ++ LS ++ SE+ EA++ K + WK K +E+
Sbjct: 451 AEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSET 510
Query: 1580 VD-IQDQEEKVVKQECIKAENQSHDYKATSE--------EDVSIKSPICEKQDESNTVIC 1630
VD + + +++K+ K E ++ Y A + DV K + E++ S
Sbjct: 511 VDELTGKNNQILKE---KDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKL 567
Query: 1631 QD-STVTSDL-LQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKRLHKRDS 1688
+D + +DL L+V + L + ++E K ++ + + V +++L I L K +
Sbjct: 568 RDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQ-SQMKVEKAHLEEE--IAELKKSQA 624
Query: 1689 FDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQEKSLIG 1748
D L E + I D+S++ L + + + V + KS+ +E + I
Sbjct: 625 QDKAKLLEMQE-SIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATII 683
Query: 1749 LKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGLKEDNDTIN 1808
+ DV E K D+ + + +T E L +H K++
Sbjct: 684 TQLKLERDVHQRELK--DLTSSLQSVKTKHEQNIQE---LMKH--------FKKEKSEAE 730
Query: 1809 DSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTVGPCLGD 1868
+ + + +S E + G + + CD + E L E+ N+ K CL D
Sbjct: 731 NHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEE---LTQNENENKKLKLKYQCLKD 787
Query: 1869 SKNVSQESLETKEEKPEETPKMELSLEN 1896
++ + +EE + L L++
Sbjct: 788 QLEEREKHISIEEEHLRRMEEARLQLKD 815
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 59.7 bits (143), Expect = 3e-08
Identities = 181/930 (19%), Positives = 356/930 (38%), Gaps = 179/930 (19%)
Query: 1343 VHLSESTMEHDNT----KLKAATVENAVLLETNTVEEK-------NVEINLESKENTPPV 1391
V++S+ + +D T K A + V N+ +EK + +++L+S N+ +
Sbjct: 454 VNISQCYLAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKIL 513
Query: 1392 VISA----------DQMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQKK 1441
+ D M +ED ++ ++T ++ E ++ T E SH++K
Sbjct: 514 NVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEK 573
Query: 1442 ERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQE---NLIEKGSNLHEKTLGETSANAE 1498
+ + + L+K ++ K + L + I E+ QE ++ ++ E L E E
Sbjct: 574 RKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEE 633
Query: 1499 TEQNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSE 1558
+ + + + G D +++++ + T+ +T A+ L ++ ++ +
Sbjct: 634 NAERRLAIFKDLV-----GKCDTREEAAKDIC--ATKVETEEATACL--ELKFNQIKAEL 684
Query: 1559 AKEEGSRKKRSGKWKNKSNES----VDIQDQEEKVVKQ-----ECIKAENQSHDYKATSE 1609
AK +G K + K + NES +++ +K++ Q E I +Q D T
Sbjct: 685 AKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKED---TIN 741
Query: 1610 EDVSIKSPI-----CEKQDESNTVICQDSTVTSDLLQVP-DDLPNVCEEKNETSKYAEYS 1663
E ++KS + C + +++++I + + ++ ++VP D +C E+ ++ E
Sbjct: 742 EFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNE-NELQ 800
Query: 1664 FTSLPVPESNLRTRNAIKRLHKRDSFDNCSLGESSKIGISDIS----------------- 1706
P + ++ +AI K+ ++ E I + +
Sbjct: 801 QDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKN 860
Query: 1707 -------------------SLSEKTFQTL--ECQHKRSRRVRRSKGCDCCGEKSQPQEKS 1745
SLSEK TL E Q +S K+Q QE+
Sbjct: 861 EKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEK 920
Query: 1746 LIGLKN---------TEN-NDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVN 1795
++ L N T N + +++ TK +++ S S+ S +D + +
Sbjct: 921 IMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISN---------IDLLNLRD 971
Query: 1796 FHLGLKEDN------DTI-NDSLIVSETK-------SKENTMQESLPSGIVNFREEICDM 1841
G +EDN D + ND L+ + K ++EN+ S+ I +EI
Sbjct: 972 LSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSI-EAIWEECKEIVKA 1030
Query: 1842 DSSEAMSLESQESPNE-------NFKTVGPCLGDSKNVSQESLETKEEKPEETPKMELSL 1894
S ++ +E E E +K L + ++ +Q+ L ++E + K EL
Sbjct: 1031 SSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQE 1090
Query: 1895 ENVTVEGNACKVTES-----------NLEKAKTMELNVGNEASFHGQERTKTGISEEAAI 1943
+NVT++ V E KAK EL E K S A +
Sbjct: 1091 KNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQ-------KVECSHSAKL 1143
Query: 1944 EENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGELDGGN 2003
E++ +S + N KE E + + + +L + EI++ T N
Sbjct: 1144 EQDILEKESIILKLERNLKEF-QEHLQDSVKNTKDLNVKELKLKEEITQLT--------N 1194
Query: 2004 DVSDL-------HSSEETNTK--MKNNEEMMIGEAMAET-GHDGETENEGITTKTSKPDE 2053
++ D+ EETN + K EE+ A + D + + E K +
Sbjct: 1195 NLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTD 1254
Query: 2054 AETNMLTAEMDNFVCDTVEMSTEEGIIDANKTETNTEYSKSEEKLDNNQMVMESDILQED 2113
A+ + + + V M E+ ++ E + ++ ++LD Q ++ ++
Sbjct: 1255 AKKQIKQVQKEVSV-----MRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQ---LKE 1306
Query: 2114 HHTSQKVEEPSQ---CLASGTAISELIIED 2140
+QKVEE Q + E IIED
Sbjct: 1307 QLNNQKVEEAIQQYERACKDLNVKEKIIED 1336
Score = 48.1 bits (113), Expect = 1e-04
Identities = 194/1160 (16%), Positives = 436/1160 (37%), Gaps = 161/1160 (13%)
Query: 986 TENSQLNVKISGMERKSNGKRDSFLAQTKNKKENMKPAAKL--KLESSSLKVKGEILLEE 1043
T+N ++ I+ +++K + + + +N K +M+ K K ++SSL + +++ E
Sbjct: 721 TQNQRIKELINIIDQK-----EDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNE 775
Query: 1044 EKSTDFVFIPPEGKDAKERILTDHQK-EVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEP 1102
V +P KD+K +I ++ ++ + ++ + PA ++ VS Q EE
Sbjct: 776 T-----VEVP---KDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEV 827
Query: 1103 M-------EIPTLTRKPKEDSKMMIT-EEQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNE 1154
+I L + ++T E ++ ++ ++ + + ++ SLS +
Sbjct: 828 RPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQ--IVHFQQELSLSEKK 885
Query: 1155 CGSLDKTSPEMSNS--------------NNDERKKALISSRKTSTECASSTENSFVVSSS 1200
+L K ++ ++ N ++ +K + S + T S T N VS
Sbjct: 886 NLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNN---VSQI 942
Query: 1201 SVSNTTVAGTPPYPTSRRQTFITLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTD 1260
+ +T + + + + I L + L+N S + N Q ++ D
Sbjct: 943 KLMHTKIDELRTLDSVSQISNIDL----------LNLRDLSNGSEEDNLPNTQLDLLGND 992
Query: 1261 FLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEG 1320
+L + +E + + E + + + + K ++++ +K+ +
Sbjct: 993 YLVSKQVKEYRIQEPNRENSFHSSIEAIW----------EECKEIVKASSKKSHQ----- 1037
Query: 1321 IVVLENNPPGLLNQTECVSDNQVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVEI 1380
I LE L + + D L E EH N E + ++EKNV +
Sbjct: 1038 IEELEQQIEKLQAEVKGYKDENNRLKEK--EHKNQDDLLKEKETLIQQLKEELQEKNVTL 1095
Query: 1381 NLESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQK 1440
+++ + V+ + ++E +Q K + ++ VE + ++ +++ +K
Sbjct: 1096 DVQIQH-----VVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEK 1150
Query: 1441 KERRKEEEKPLQKSPLHIKDDVLPKQKL-IAEQTLQENLIEKGSNLHEKTLGETSANAET 1499
+ + E+ L++ H++D V + L + E L+E + + +NL + + E
Sbjct: 1151 ESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQD--MKHLLQLKEE 1208
Query: 1500 EQNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEA 1559
E+ + + E +K E + SS + +Q L + ++ E D ++
Sbjct: 1209 EEETNRQETEKLKEE-------LSASSAR-------------TQNLKADLQRKEEDYADL 1248
Query: 1560 KEEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSH---DYKATSEEDV--SI 1614
KE+ + K+ K K + +D+ ++ E K +NQ D K + + + +
Sbjct: 1249 KEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQL 1308
Query: 1615 KSPICEKQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNL 1674
+ E+ + C+D V ++ +D+ EE+ +T + + L
Sbjct: 1309 NNQKVEEAIQQYERACKDLNVKEKII---EDMRMTLEEQEQTQVEQDQVLEAKLEEVERL 1365
Query: 1675 RT-----RNAIKRLHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRS 1729
T + L +++ + E++ + +++L ++ ++ + + ++
Sbjct: 1366 ATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEE 1425
Query: 1730 KGCDCCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQ--- 1786
K K ++ K E+ + + + ++ + S + E +
Sbjct: 1426 KMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQL 1485
Query: 1787 --FLDEHHSVNFHLGLKEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSS 1844
L+ +++DN+ I+SET E + + P I + D D
Sbjct: 1486 VAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISS-----ADPDKL 1540
Query: 1845 EAMSLESQESPNENFKTVGPCLGDSKNVSQESLETKEEKPEETPKMELSLENVTVEGNAC 1904
+ L + + N G + DS VS T+ ++ PK EL ++ ++ N
Sbjct: 1541 QTEPLSTSFEISRNKIEDGSVVLDSCEVS-----TENDQSTRFPKPELEIQFTPLQPNKM 1595
Query: 1905 KVTESNLEKAKTMELNVGNEASFHGQERTKTGISEEAAIEENKRN-----------DDSE 1953
V T+++ ++R + E+ ENK+N D
Sbjct: 1596 AVKHPGCTTPVTVKIP-------KARKRKSNEMEEDLVKCENKKNATPRTNLKFPISDDR 1648
Query: 1954 ADTAKLNAKEVATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGELDGGNDVSDLHSSEE 2013
+ K K SL + + +N T+ E G L D HS
Sbjct: 1649 NSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKE----GTLQKFGDFLQ-HSPSI 1703
Query: 2014 TNTKMKNNEEMMIGEAMAETGHDGETENEGITTKTSKPDEAETNMLTAEMDNFVCDTVEM 2073
+K K E M ++ E E + S+P A+ + T+E + +++
Sbjct: 1704 LQSKAKKIIETMSSSKLSNV----EASKENV----SQPKRAKRKLYTSE----ISSPIDI 1751
Query: 2074 STEEGIIDANKTETNTEYSK 2093
S + ++D E++ + K
Sbjct: 1752 SGQVILMDQKMKESDHQIIK 1771
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 59.3 bits (142), Expect = 5e-08
Identities = 243/1261 (19%), Positives = 479/1261 (37%), Gaps = 197/1261 (15%)
Query: 944 MLVYPEELKPVLTQAKQK-FLLLLPGLETVEMMEESSGPYSDGTENSQLNVKISGMERKS 1002
M EEL+ ++++ F L L T + EE+ ++++ +I +E+ S
Sbjct: 394 MTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLK-----AEMDEQIKTIEKTS 448
Query: 1003 NGKRDSF---LAQTKN------KKENMKPAAKL-KLESSSLKVKGEILLEEEKSTDFVFI 1052
+R S L++ K KK + + AKL KL L K + L ++ ++ + F
Sbjct: 449 EEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREF- 507
Query: 1053 PPEGKDAKERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKP 1112
+ K A E+ +++ K + + K L++ + + T+ S+ + ++ ++
Sbjct: 508 QEQMKVALEKSQSEYLK-ISQEKEQQESLALEELELQKKAILTE-SENKLRDL----QQE 561
Query: 1113 KEDSKMMITEEQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNE--CGSLDKTSPEMSNSNN 1170
E + I E + + + ++ + +A HLE +N+ ++K E+ + +
Sbjct: 562 AETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKH 621
Query: 1171 DE----RKKALISSRKTSTECASSTENSFVVSSSSVSNTTVAGTPPYPTSRRQTFITLEK 1226
+ +K + ++ TE E + + + + +T LEK
Sbjct: 622 QQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKT---LEK 678
Query: 1227 FDGSENRPFSPSPLNNISSTVTVKNNQETMIKTDFLPKAKQREGTFSKSDSEK------- 1279
D + S S + K +E + D K KQ +K D +K
Sbjct: 679 LDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQE--LEAKMDEQKNHHQQQV 736
Query: 1280 --IVNGTKRSSRRAGKAEQTGNKRSKPLMRSEPE--KNTEESVEGIVVLENNPPGLLNQT 1335
I+ + S +R KA + + + L++ + K + VE + G L Q
Sbjct: 737 DSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQA 796
Query: 1336 ECVSDNQVHLSESTMEHDNTKL---KAATVENAVL-LETNTVEEKNVEINLESKENTPPV 1391
D V S + H+ TK + A ++ +L LET + +E+++
Sbjct: 797 SAKLD--VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCT 854
Query: 1392 VISADQMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQKKERRKEEEKPL 1451
+ A ++ +D Q+ + + + ++V ES E +KE K+ ++E L
Sbjct: 855 ELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMIL 914
Query: 1452 QKSPLHIKDDVLPKQKLIAEQ----TLQENLIEKGSNLHEKTLGETSANAETEQ---NKK 1504
Q K+ + QKL A++ L E K N EK + + A+ Q KK
Sbjct: 915 QMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKN-QEKKMEKVKQKAKEMQETLKKK 973
Query: 1505 KADPE-NIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGL---LSSIENSESDSSEAK 1560
D E +K E + T + EK + + S G+ +S +E ++ + E+
Sbjct: 974 LLDQEAKLKKELENTA-LELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESL 1032
Query: 1561 EEGSRKKRS---GKWKNKSNE---------SVDIQDQEEKV--VKQECI----KAENQSH 1602
E R++ + W+ K N+ + +Q++E++V +KQ+ + + E +
Sbjct: 1033 TEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNK 1092
Query: 1603 DYKATSEEDVSIKSPICEKQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEY 1662
+ EE V + + E Q++ +++ D ++ L + + N++ K E
Sbjct: 1093 EITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLK--EN 1150
Query: 1663 SFTSLPVPESNLRTRNAIKRLHKRDSFDNCSLGESSKIGISDISS---LSEKTFQTLECQ 1719
+F + E + L E K +S+++S +++ FQ+L+
Sbjct: 1151 TFLQEQLVELKM-------------------LAEEDKRKVSELTSKLKTTDEEFQSLKSS 1191
Query: 1720 HKRSRRVRRSKGCDCCGEKSQPQEKSLIGLKNTE-------NNDVEISETKKADVQAPVS 1772
H++S + K + + + I K TE N + IS +K + + +S
Sbjct: 1192 HEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRIS 1251
Query: 1773 PSETSQANPYSEGQFLDEHHSVNFHLGLKEDNDTINDSLIVSETKSKENTMQESLPSGIV 1832
+ H K + + VSE +++ + E + +
Sbjct: 1252 HCQ---------------------HRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNI 1290
Query: 1833 NFREEICDMDSSEAMSLESQESPNENFKTVGPCLGDSKNVSQESLETKEEKPEETPKMEL 1892
+F++ ++ E ++S ++ E+ T L Q++ KE + K EL
Sbjct: 1291 SFQQATHQLEEKE-NQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQL-KKEL 1348
Query: 1893 SLENVTV------EGNACKVTESNLEKAKTMELNVGNEASFHGQERTKTGISEEAAIEEN 1946
S EN+ E KV S+L K T +LNV + S E+ EAAI
Sbjct: 1349 S-ENINAVTLMKEELKEKKVEISSLSKQLT-DLNVQLQNSISLSEK-------EAAISSL 1399
Query: 1947 KRNDDSEADTAKLNAKEVATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGEL--DGGND 2004
++ D E L D + T E+ +A E D N
Sbjct: 1400 RKQYDEE------------------KCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNK 1441
Query: 2005 VSDLHSSEETNTKMKNNEEMMIGEAMAETGHDGETENEGITTKTSKPDEAETNMLTAEMD 2064
S+ ++ N T + + + E + +K + + + N+L E+D
Sbjct: 1442 FSEWKKKAQSRFTQHQN-----------TVKELQIQLE-LKSKEAYEKDEQINLLKEELD 1489
Query: 2065 NFVCDTVEMSTEEGIIDANKTETNTEYSKSEEKLDNNQMVMESDILQ----EDHHTSQKV 2120
+ D K E + SK E+K N + ++S + EDH T + +
Sbjct: 1490 Q----------QNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTI 1539
Query: 2121 E 2121
E
Sbjct: 1540 E 1540
Score = 43.9 bits (102), Expect = 0.002
Identities = 201/996 (20%), Positives = 377/996 (37%), Gaps = 152/996 (15%)
Query: 1250 KNNQETMIKTDFLPKAKQREGTFSKS--DSE-KIVNGTKRSSRRAGKAEQTGNKRSKPLM 1306
KN ++ M K KAK+ + T K D E K+ + ++ + E+ N + +
Sbjct: 950 KNQEKKMEKVK--QKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMA 1007
Query: 1307 R----------SEPEKNTEESVEGIVVLENNPPGLLNQTECVSDNQVHLSESTMEH---- 1352
+ S E N +E +E + + LN + + +++ ++
Sbjct: 1008 QANSAGISDAVSRLETNQKEQIESLTEVHRRE---LNDVISIWEKKLNQQAEELQEIHEI 1064
Query: 1353 --DNTKLKAATVENAVLLETNTVEEKNVEINLESKENTPPVVISADQMVNEDSQVQITPN 1410
+ + A ++ +LL EE N EI +E + D +NE
Sbjct: 1065 QLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEG-----VKQDTTLNE--------- 1110
Query: 1411 QKTLRRSSRRRSEVVESTTESQDKENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIA 1470
L+ +++S V S + + K +H +K E L KS +K++ +++L+
Sbjct: 1111 ---LQEQLKQKSAHVNSLAQDETKLKAHLEKL-----EVDLNKS---LKENTFLQEQLVE 1159
Query: 1471 EQTLQENLIEKGSNLHEK--TLGET--SANAETEQNKKKADPENIK----SEGDGTQ-DI 1521
+ L E K S L K T E S + E++ K + ++++ SE Q DI
Sbjct: 1160 LKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDI 1219
Query: 1522 VDKSSEKLVRGRTRYQTRRASQ---GLLSSIENSESDSSEAKEE-------GSRKKRSGK 1571
K +E L+ +T +S +LS I + + +++ KE S + +
Sbjct: 1220 CCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLR 1279
Query: 1572 WKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPIC-EKQDESNTVIC 1630
+ +++I Q+ +E ENQ KA E V+ K + E ++
Sbjct: 1280 QLTEEQNTLNISFQQATHQLEE---KENQIKSMKADIESLVTEKEALQKEGGNQQQAASE 1336
Query: 1631 QDSTVTSDLLQVPDDLPNVCEEKNETS-KYAEYSFTSLPVPESNLRTRN---------AI 1680
++S +T ++ +++ V K E K E S S + + N++ +N AI
Sbjct: 1337 KESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAI 1396
Query: 1681 KRLHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQ 1740
L K+ + C L + + + +LS++ LE S + K +K+Q
Sbjct: 1397 SSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK------KKAQ 1450
Query: 1741 PQEKSLIGLKNTENN-----DVEISETKKADVQAPVSPSETSQANPYSE---GQFLDEHH 1792
+ +NT +++ E + D Q + E Q N + G+ D+
Sbjct: 1451 SR---FTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKS 1507
Query: 1793 SV-----NFHLGLKEDNDTINDSLIVSETKSKENTMQ-ESLPSGIVNFREEICDMDSSEA 1846
+ N LK I + E + T++ ESL + N+ ++ D++ E
Sbjct: 1508 KMEKKESNLETELKSQTARIMEL----EDHITQKTIEIESLNEVLKNYNQQK-DIEHKEL 1562
Query: 1847 MSLESQESPNENFKTVGPCLGDSKNVSQESLETKEE-----KPE-ETPKMELSLENVTVE 1900
+ ++F+ +G + ++E + T E K E ET K EL N++V+
Sbjct: 1563 VQ------KLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVK 1616
Query: 1901 GNA--CKVTESNLEK---AKTMELNVGNEASFHGQERTKTGISEEAAIEENKRNDDSEAD 1955
K E LE AK EL E ++ EE +E + +E+
Sbjct: 1617 SKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEE---KEEQYKKGTESH 1673
Query: 1956 TAKLNAK------EV-ATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGELDGGNDVSDL 2008
++LN K EV EE + S + T + + ++ T E D V
Sbjct: 1674 LSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKT 1733
Query: 2009 HSSE----ETNTKMKNNEEMMIGEAMAETGHDGETENEGITTKTSKPDEAETNMLTAE-- 2062
+ + + N K +G+ ET + K + AE +
Sbjct: 1734 YEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSM 1793
Query: 2063 MDNFVCDTVEMSTEEGIIDANKTETNTEYSKSEEKLDNNQMVMESDI---LQEDHHT--- 2116
+ + + E + + +I A E E K+ + N + D+ LQE T
Sbjct: 1794 IGHLQEELEEKNKKYSLIVAQHVEK--EGGKNNIQAKQNLENVFDDVQKTLQEKELTCQI 1851
Query: 2117 -SQKVEEPSQCLASGTAISELIIEDNNASPQKLREL 2151
QK++E CL + + +E+ + +KL+ L
Sbjct: 1852 LEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQAL 1887
Score = 32.7 bits (73), Expect = 4.5
Identities = 67/341 (19%), Positives = 143/341 (41%), Gaps = 33/341 (9%)
Query: 1249 VKNNQETMIKTDFLPKAKQREGTFSK---SDSEKIVNGTKRSSRRAGKAEQTGNKRSKPL 1305
+K+ + + +T +P++ + +++ +DS+ V K + ++ ++ K L
Sbjct: 1695 LKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ--KTYEEKISVLQRNLTEKEKLL 1752
Query: 1306 MRSEPEKNTEESVEGIVVLENNPPGLLNQTECVSDNQVHLSESTMEHDNTKLKAATVENA 1365
R EK EE+V + L + E Q H +S + H +L+ + +
Sbjct: 1753 QRVGQEK--EETVSSHFEMRCQYQERLIKLEHAEAKQ-HEDQSMIGHLQEELEEKNKKYS 1809
Query: 1366 VLLETNTVEEKNVEINLESKENTPPVVISADQMVNE-DSQVQITPNQ-KTLRRSSRRRSE 1423
+++ + VE++ + N+++K+N V + + E + QI + K L R+ E
Sbjct: 1810 LIVAQH-VEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKE 1868
Query: 1424 V----VESTTESQDKENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLI 1479
V +E T +K + Q+ + R + + L+++ L + KL++ Q N +
Sbjct: 1869 VHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDL 1928
Query: 1480 E---KGSNLHEKTLGE-------------TSANAETEQNKKKADPENIKSEGDGTQDIVD 1523
E G+ ++ LG+ E E KK+ D E + +D+
Sbjct: 1929 EFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLEL 1988
Query: 1524 KSSEKLVRGRTRYQTRRA--SQGLLSSIENSESDSSEAKEE 1562
K + L + + T+ A Q L +I+ + + + E + E
Sbjct: 1989 KHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAE 2029
>gi|109637791 transcription factor-like nuclear regulator [Homo
sapiens]
Length = 2624
Score = 59.3 bits (142), Expect = 5e-08
Identities = 202/1144 (17%), Positives = 424/1144 (37%), Gaps = 148/1144 (12%)
Query: 1095 TQYSQEEPMEIPTLTRKPK-------EDSKMMITEEQMDSDIVIPQDVTEDCG---MAEH 1144
+Q P+++ +KPK E +++I++E++ +++ ++ E C +H
Sbjct: 694 SQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANV--EKNENESCADRDTPQH 751
Query: 1145 LEKSSLSNNECGSLDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSSSSVSN 1204
+E S + E + + ND + K EC S EN+ + V
Sbjct: 752 MEDQSRKDFE-----EEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPI 806
Query: 1205 TTVAGTPPYP-----TSRRQTFITLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKT 1259
P P T RR+ K + E S + TV + + + M+
Sbjct: 807 LRTRFQKPKPNIGRGTGRREIS---SKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPA 863
Query: 1260 DFLPKAKQRE----GTFSKSDSEKIVN----------GTKRSSRRAGKAEQTG------- 1298
+ K Q + G + S EKI++ G K R E+T
Sbjct: 864 EINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATE 923
Query: 1299 --NKRSKPLMRSE--PEKNTEESVEGIVVLENNPPGLLNQTECVSDNQVHLSESTMEHDN 1354
+K + R E P+KN E V+ + +E + N++ + ++++T E D
Sbjct: 924 EIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESS-PREKTPEVTDATEEIDK 982
Query: 1355 T-----KLKAATVENAVLLETNTVEEKNVEINLESKEN-----TPPVVISADQMVNEDSQ 1404
+ K + EN E V+E ++N +E+ TP V+ + +++ E+++
Sbjct: 983 NLEETGRRKISPRENGPE-EVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETE 1041
Query: 1405 VQITPNQKTL---RRSSRRRSEVVESTTESQDKENSHQKKERRKEEEKPLQKSPLHI--K 1459
+++P + L + +++ + +S + + + + +E E L+++ I +
Sbjct: 1042 REVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQ 1101
Query: 1460 DDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQNKKKADPENIKSEGDGTQ 1519
++ L + K + E + + EKT A E +++ ++ I E +G +
Sbjct: 1102 ENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPE 1161
Query: 1520 DI--VDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRS-GKWKNKS 1576
++ VD+ L +R ++ ++ + E E+D E + E S ++ + K
Sbjct: 1162 EVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVG 1221
Query: 1577 NESVDIQDQEEKVVKQECIKAE-----NQSHDYKATSEEDVSIKSPICEKQDESNTVICQ 1631
D+++ E++ ++E + AE + D K T + D+ PI EK V+
Sbjct: 1222 KMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDI----PIMEKVSGKMAVV-- 1275
Query: 1632 DSTVTSDLLQVPDD------LPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKR--L 1683
+ +DL + + +C + + ++ + T + E+ L + ++
Sbjct: 1276 -EEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDT 1334
Query: 1684 HKRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQE 1743
H S N + S + DI ++S + L H R S+ E S
Sbjct: 1335 HLMQSGSN----DFSAVPSLDIQNISS---EVLSMMHTPVEEKRNSE-----KEVSSHFS 1382
Query: 1744 KSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGLKED 1803
I + E++ E+ + DV S S++ P E + L+ + K
Sbjct: 1383 HFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLP-QEQKPLEIKPAPFVRSRFKRP 1441
Query: 1804 NDTINDSLIVSET---------KSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQES 1854
+ + + ET K E E++ N + + EA + S+E
Sbjct: 1442 KPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREK 1501
Query: 1855 PNENFK----TVGPCLGDSKNVS-QESLETKEEK---PEETPKMELSLENVTVEGNACKV 1906
+ + PC +N+S S E KEE P + +S+ V ++
Sbjct: 1502 DTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEM 1561
Query: 1907 TESNLEKAKTMELNVGN---EASFHGQERTKTGISEEAAIEENKR---NDDSEADTAKLN 1960
ES ++ A+ + + GQ + + I+E + D++E ++
Sbjct: 1562 KESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVS 1621
Query: 1961 AKEVATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKMKN 2020
++ TE I + + P + E Q V +LH + +TN +++
Sbjct: 1622 NSQIETE-----IEVPSSAVPE--HRMYENQSQVVL--------VENLHVN-KTNETIRH 1665
Query: 2021 NEEMMIGEAMAETGHDGETENEGITTKTSKPDEAETNMLTAEMDNFVCDTVEMSTEEGII 2080
+ + + T + + SK +E +T + E E+ ++
Sbjct: 1666 ENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSK------EGKPEDHLL 1719
Query: 2081 DANKTETNTEYSKSEEKLDNNQMVMESDILQEDHHTSQKVEEPSQCLASGTAISELIIED 2140
+ T + E L + ++ D + K++ + + + E + D
Sbjct: 1720 QKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGD 1779
Query: 2141 NNAS 2144
N+ S
Sbjct: 1780 NSPS 1783
Score = 40.4 bits (93), Expect = 0.022
Identities = 147/782 (18%), Positives = 264/782 (33%), Gaps = 192/782 (24%)
Query: 946 VYPEELKPVLTQAKQKFLLLLPGLETVEMMEESSGPYS-DGTENSQLNVKISGMERKSNG 1004
+ P E P + A ++ L E+ E +GP + + ++K +G E S
Sbjct: 1125 ISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSRE 1184
Query: 1005 KR-----------------DSFLAQTKNKKENMKPAAKLKLESSSLKVKGEILLEEEKST 1047
K + ++ +N E +KP K+ E+ +++ EI E+
Sbjct: 1185 KTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKM--ETDLKEIREEISQREKVLA 1242
Query: 1048 DFVFIPPEGKDAKERILTDHQ-KEVLKTKRCDIPAMYNNLDVSQDTLFTQYSQEE----P 1102
+F I + D KE D E + K + M +L + F + EE
Sbjct: 1243 EFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTE 1302
Query: 1103 MEIPTLTRKPKED-----SKMMITEEQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNECGS 1157
++ L + K D +++ T +D + Q + D L+ ++S+
Sbjct: 1303 EKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSM 1362
Query: 1158 LDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSSSSVSNTTVAGTPPYPTSR 1217
+ E NS + +SS + + +S T S T V G
Sbjct: 1363 MHTPVEEKRNSEKE------VSSHFSHFKISSQTHES--------DKTEVQGIQSPDVPE 1408
Query: 1218 RQTFITLEKFDGSENRPFSPSPLNNISS-------------------------------- 1245
+ + I L K E +P P + S
Sbjct: 1409 QFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSET 1468
Query: 1246 ----TVTVKNNQETMIKTDFLPKA--------KQREGTFSKSDSEKIV---NGTKRSSRR 1290
T+ ++ N E +TD LP + + T + E ++ T+R+
Sbjct: 1469 KKMETIVMQENNE---QTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSP 1525
Query: 1291 AGKAEQTGNKRSKPLMRSEP-------EKNT--EESVEGIVVLENNPPGLLN-------- 1333
+ E +S P+ +++ NT +E E ++ G L
Sbjct: 1526 SNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRK 1585
Query: 1334 --QTECVSDNQ----VHLSESTMEHDNTKLKAATVENA---------------------- 1365
Q + V + + + + D T+ K TV N+
Sbjct: 1586 TGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQ 1645
Query: 1366 ---VLLETNTVEEKNVEINLESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRS 1422
VL+E V + N I E+K P V S+ QM Q + PN R S++
Sbjct: 1646 SQVVLVENLHVNKTNETIRHENK----PYVPSSAQMTRRKFQ-KAKPNLG--RAHSKKEE 1698
Query: 1423 EVVESTTESQDKENSHQKKERRKE--------EEKPLQKSPLHI---KDDVLPKQKLIAE 1471
V+E T Q KE + +K +EK + L + KD V K+ +A+
Sbjct: 1699 PVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAK 1758
Query: 1472 QTLQENLIEKGSNLHEKTLGETSANAETEQ---NKKKADPENIKSEG------DGTQDIV 1522
+ + + E+T+G+ S ++ E+ NK + P+ + DG I
Sbjct: 1759 IDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTIS 1818
Query: 1523 DKSS-----------------------EKLVRGRTRYQTRRASQGLLSSIENSESDSSEA 1559
S K VRG+T + RAS+ +L ++ S+ + +A
Sbjct: 1819 STSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDA 1878
Query: 1560 KE 1561
+
Sbjct: 1879 DD 1880
>gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]
Length = 1462
Score = 57.4 bits (137), Expect = 2e-07
Identities = 117/540 (21%), Positives = 212/540 (39%), Gaps = 79/540 (14%)
Query: 1162 SPEMSNSNNDERKKALISSRKTSTEC------------ASSTENSFVVSSSSVSNTT--- 1206
S S+S + RK+A S RKT+++ A+ +N VV V+
Sbjct: 549 SKSRSSSKSGHRKRASKSPRKTASQLSENKPVKTEPLRATMAQNENVVVQPVVAENIPVI 608
Query: 1207 -VAGTPPYPTSRRQTFITLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTDFLPKA 1265
++ +PP + ++ + + L I ST ++ N +ET + + +
Sbjct: 609 PLSDSPPPSRWKPGQKPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKRE 668
Query: 1266 KQREG---TFSK-SDSEKIVNGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEGI 1321
K E T+SK SD + RS ++ RS+ L S + S
Sbjct: 669 KNSESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPSS---- 724
Query: 1322 VVLENNPPGLLNQTECV-SDNQVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVEI 1380
++ + ++C S + +S +L+++ +N+V ++ + E
Sbjct: 725 --RSHSRNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSV---SHKKHSSSSEK 779
Query: 1381 NLESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDK------ 1434
L SK V D+ + + ++ +L SS V++T +Q+K
Sbjct: 780 TLHSK-----YVKGRDR---SSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQGQM 831
Query: 1435 ENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENL---IEKGSNLHEKTLG 1491
E +H K+E+ + EEK KS + P K ++TL+ENL + GS K
Sbjct: 832 ERTHNKQEKNRGEEK--SKS-----ERECPHSK---KRTLKENLSDHLRNGSKPKRKNYA 881
Query: 1492 ----ETSANAE---TEQNKKKADPENIKSEGDGTQDIVDKSSE--KLVRGRTRYQTRRA- 1541
++ +N+E T+ +K + P + K EG+ T D + SE V+ T+ T +
Sbjct: 882 GSKWDSESNSERDVTKNSKNDSHPSSDKEEGEATSDSESEVSEIHIKVKPTTKSSTNTSL 941
Query: 1542 ---SQGLLSSIENSESDSSEAKEEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAE 1598
+ SS + + + SE S R K+K +++ + K VK++ +
Sbjct: 942 PDDNGAWKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKLKGKK 1001
Query: 1599 NQSHDYKATSEEDVSIKSPICEKQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSK 1658
++ H KA + P E +E I D VT + + E NET K
Sbjct: 1002 DKKH--KAPKRKQAFHWQPPLEFGEEEEEEI-DDKQVTQESKE------KKVSENNETIK 1052
Score = 56.6 bits (135), Expect = 3e-07
Identities = 167/844 (19%), Positives = 307/844 (36%), Gaps = 94/844 (11%)
Query: 1230 SENRPFSPSPLNNISS-TVTVKNNQETMIKTDFLPKAKQREGTFSKSDSEKIVNGTKRSS 1288
S R +S S + SS T + +++ + + + R T SKS S RSS
Sbjct: 495 SSKRDWSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKSRSS 554
Query: 1289 RRAG---KAEQTGNKRSKPLMRSEPEK---------NTEESVEGIVVLENNPPGLLNQTE 1336
++G +A ++ K + L ++P K E V VV EN P L+ +
Sbjct: 555 SKSGHRKRASKSPRKTASQLSENKPVKTEPLRATMAQNENVVVQPVVAENIPVIPLSDSP 614
Query: 1337 CVS---DNQVHLSESTMEHDNTKLKA-------ATVENAVLLETNTVEEKNV-EINLESK 1385
S Q S K K +T A + ET + + E N ES
Sbjct: 615 PPSRWKPGQKPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNSESD 674
Query: 1386 ENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQKKERRK 1445
++T + S+ + + ++ R +R RS + SH + +
Sbjct: 675 QSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPSSRSHSRNKYSD 734
Query: 1446 EEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLI--EKGSNLHEKTLGETSANAETEQNK 1503
+ S I D + K + ++N + +K S+ EKTL +++ + +
Sbjct: 735 HSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTL-----HSKYVKGR 789
Query: 1504 KKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEG 1563
++ SE + D S + V+ T+ + QG + N + EE
Sbjct: 790 DRSSCVRKYSESRSSLDYSSDSEQSSVQA-TQSAQEKEKQGQMERTHNKQ--EKNRGEEK 846
Query: 1564 SRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQD 1623
S+ +R K ++ D K + D ++ SE DV+ S K D
Sbjct: 847 SKSERECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWDSESNSERDVTKNS----KND 902
Query: 1624 ESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKRL 1683
+ ++ TSD ++ + + T+K S T+ +P+ N +++ +R
Sbjct: 903 SHPSSDKEEGEATSD---SESEVSEIHIKVKPTTK----SSTNTSLPDDNGAWKSSKQRT 955
Query: 1684 HKRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQE 1743
DS +CS E+++ + + L+ +H + + + KG K+ ++
Sbjct: 956 STSDSEGSCSNSENNR---GKPQKHKHGSKENLKREHTKKVK-EKLKGKKDKKHKAPKRK 1011
Query: 1744 KSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGLKED 1803
++ E + E E V + S+ N + L S L K D
Sbjct: 1012 QAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSEEDLSGKHD 1071
Query: 1804 NDTI----------NDSLIVSET--KSKENT--------MQESLPSGIVNFRE-----EI 1838
T+ + L +S T ++EN ++ES+P+G+ + + EI
Sbjct: 1072 TVTVSSDLDQFTKDDSKLSISPTALNTEENVACLQNIQHVEESVPNGVEDVLQTDDNMEI 1131
Query: 1839 CDMDSSEAMSLESQESPNENFKTVGPCLGDSKNVSQESLETKEEKPEETPKMELSLENVT 1898
C D S +E + SP N + P D V ++ + T E E K E S+
Sbjct: 1132 CTPDRSSPAKVE-ETSPLGNARLDTP---DINIVLKQDMAT-EHPQAEVVKQESSMSESK 1186
Query: 1899 VEGNACKVTESNLEKAKTMELNVGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAK 1958
V G K S+ A G+ K ++E++ I +
Sbjct: 1187 VLGEVGKQDSSSASLASA------------GESTGKKEVAEKSQINLIDKKWKPLQGVGN 1234
Query: 1959 LNAKEVATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKM 2018
L A AT +S + + TT ++ Q E + ++ G+ ++ + N +
Sbjct: 1235 LAAPNAAT---SSAVEVKVLTTVPEMKPQGLRIEIKSKNKVRPGSLFDEVRKTARLNRRP 1291
Query: 2019 KNNE 2022
+N E
Sbjct: 1292 RNQE 1295
Score = 56.6 bits (135), Expect = 3e-07
Identities = 141/765 (18%), Positives = 278/765 (36%), Gaps = 126/765 (16%)
Query: 1375 EKNVEINLESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDK 1434
+K+V+ +L S Q + S T ++ + SR +S + +
Sbjct: 504 DKDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKSRSSSKSGHRKRA 563
Query: 1435 ENSHQKKERRKEEEKPLQKSPLHI---KDDVLPKQKLIAE-------------------- 1471
S +K + E KP++ PL +++ + Q ++AE
Sbjct: 564 SKSPRKTASQLSENKPVKTEPLRATMAQNENVVVQPVVAENIPVIPLSDSPPPSRWKPGQ 623
Query: 1472 -------QTLQE------NLIEKGSNLHEKTLGETSANAETEQNKKKADPENIKSEGDGT 1518
+ +QE +L+ S + ET +++ + +K N +S+
Sbjct: 624 KPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREK-----NSESDQSTY 678
Query: 1519 QDIVDKSSEKLVRGRTRYQTRRA-------SQGLLSSIENSESDSSEAKEEGSRKKRSGK 1571
D+SSE R R+R R+ S+ L SS S S SS + S
Sbjct: 679 SKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPSSRSHSRNKYSDHSQC 738
Query: 1572 WKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDESNTVICQ 1631
++ S S+ D + +N K +S + ++ S + +D S+ V
Sbjct: 739 SRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCV--- 795
Query: 1632 DSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKRLHKRDSFDN 1691
+ +E+ +YS S +S+++ + + K+ +
Sbjct: 796 -------------------RKYSESRSSLDYSSDS---EQSSVQATQSAQEKEKQGQMER 833
Query: 1692 CSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQEKSLIGLK- 1750
+ G EK+ EC H + R ++ + D S+P+ K+ G K
Sbjct: 834 THNKQEKNRG-------EEKSKSERECPHSKKRTLKENLS-DHLRNGSKPKRKNYAGSKW 885
Query: 1751 -NTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSV------NFHLGLKED 1803
+ N++ ++++ K D P S E +A SE + + H V + + L +D
Sbjct: 886 DSESNSERDVTKNSKND-SHPSSDKEEGEATSDSESEVSEIHIKVKPTTKSSTNTSLPDD 944
Query: 1804 NDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTVG 1863
N S + T E + S + + + S E + E + E K
Sbjct: 945 NGAWKSSKQRTSTSDSEGSCSNSENN---RGKPQKHKHGSKENLKREHTKKVKEKLKG-- 999
Query: 1864 PCLGDSKNVS---------QESLETKEEKPE---------ETPKMELSLENVTVEGNACK 1905
D K+ + Q LE EE+ E E+ + ++S N T++ N K
Sbjct: 1000 --KKDKKHKAPKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILK 1057
Query: 1906 VTESNLE--KAKTMELNVGNEASFHGQERTKTGISEEAA-IEEN---KRNDDSEADTAKL 1959
+S+ E K + V ++ ++ +K IS A EEN +N ++
Sbjct: 1058 TEKSSEEDLSGKHDTVTVSSDLDQFTKDDSKLSISPTALNTEENVACLQNIQHVEESVPN 1117
Query: 1960 NAKEVATEEFNSDISLSDNTTPVKLNAQTEISE---QTAAGELDGGNDVSDLH-SSEETN 2015
++V + N +I D ++P K+ + + T + D++ H +E
Sbjct: 1118 GVEDVLQTDDNMEICTPDRSSPAKVEETSPLGNARLDTPDINIVLKQDMATEHPQAEVVK 1177
Query: 2016 TKMKNNEEMMIGEAMAETGHDGETENEGITT-KTSKPDEAETNML 2059
+ +E ++GE + + G +T K ++++ N++
Sbjct: 1178 QESSMSESKVLGEVGKQDSSSASLASAGESTGKKEVAEKSQINLI 1222
Score = 52.0 bits (123), Expect = 7e-06
Identities = 88/426 (20%), Positives = 160/426 (37%), Gaps = 56/426 (13%)
Query: 1146 EKSSLSNNECGSLDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSF-------VVS 1198
E+SS+ + + +M ++N + K K+ EC S + + + +
Sbjct: 812 EQSSVQATQSAQEKEKQGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRN 871
Query: 1199 SSSVSNTTVAGTPPYPTSRRQTFITLEKFDGS---------ENRPFSPSPLNNISSTV-- 1247
S AG+ S + +T + S E S S ++ I V
Sbjct: 872 GSKPKRKNYAGSKWDSESNSERDVTKNSKNDSHPSSDKEEGEATSDSESEVSEIHIKVKP 931
Query: 1248 TVKNNQETMIKTD--FLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRSKPL 1305
T K++ T + D +KQR T SDSE S GK Q SK
Sbjct: 932 TTKSSTNTSLPDDNGAWKSSKQRTST---SDSE---GSCSNSENNRGKP-QKHKHGSKEN 984
Query: 1306 MRSEPEKNTEESVEGIVVLENNPPGLLNQ------TECVSDNQVHLSESTMEHDNTKLKA 1359
++ E K +E ++G ++ P E + + + + + ++ + K
Sbjct: 985 LKREHTKKVKEKLKGKKDKKHKAPKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKV 1044
Query: 1360 ATVENAVLLETNTVE-EKNVEINLESKENTPPVVISADQMVNEDSQVQITP--------- 1409
+ EN ++ N ++ EK+ E +L K +T V DQ +DS++ I+P
Sbjct: 1045 S--ENNETIKDNILKTEKSSEEDLSGKHDTVTVSSDLDQFTKDDSKLSISPTALNTEENV 1102
Query: 1410 ----NQKTLRRSSRRRSEVVESTTESQDKENSHQKKERRKEEEKPLQKSPLHIKD-DVLP 1464
N + + S E V T ++ + + + EE PL + L D +++
Sbjct: 1103 ACLQNIQHVEESVPNGVEDVLQTDDNMEICTPDRSSPAKVEETSPLGNARLDTPDINIVL 1162
Query: 1465 KQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQNKKKADPENIKSEGDGTQDIVDK 1524
KQ + E E + ++ S K LGE + + A E G +++ +K
Sbjct: 1163 KQDMATEHPQAEVVKQESSMSESKVLGEVGKQDSSSASLASA------GESTGKKEVAEK 1216
Query: 1525 SSEKLV 1530
S L+
Sbjct: 1217 SQINLI 1222
Score = 37.0 bits (84), Expect = 0.24
Identities = 120/602 (19%), Positives = 209/602 (34%), Gaps = 62/602 (10%)
Query: 978 SSGPYSDGTENSQLNVKISGMERKSNGKRDSFLAQTKNKKENMKPAAKLKLESSSLKVKG 1037
SS YS +E S + S E++ G+ + +T NK+E K +G
Sbjct: 803 SSLDYSSDSEQSSVQATQSAQEKEKQGQME----RTHNKQE---------------KNRG 843
Query: 1038 EILLEEEKSTDFVFIPPEGKDAKERILTDHQKEVLKTKRCDIPAMYNNLDVSQDTLFTQY 1097
E EKS P K + L+DH + K KR + + + + + T+
Sbjct: 844 E-----EKSKSERECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWDSESNSERDVTKN 898
Query: 1098 SQEEPMEIPTLTRKPKEDSKMMITEEQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNECGS 1157
S+ + + KE+ + E S+I I T L + +
Sbjct: 899 SKND-----SHPSSDKEEGEATSDSESEVSEIHIKVKPTTKSSTNTSLPDDNGAWKSSKQ 953
Query: 1158 LDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSSSSVSNTTVAGTPPYPTSR 1217
TS + +N E + K ++ E++ V P R
Sbjct: 954 RTSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKLKGKKDKKHKAP---KR 1010
Query: 1218 RQTFITLE--KFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTDFLPKAKQREGTFSKS 1275
+Q F +F E + S V N ET IK + L K
Sbjct: 1011 KQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNET-IKDNILKTEKS-------- 1061
Query: 1276 DSEKIVNGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEGIVVLENNPPGLLNQT 1335
SE+ ++G + + +Q SK L S NTEE+V + +++ + N
Sbjct: 1062 -SEEDLSGKHDTVTVSSDLDQFTKDDSK-LSISPTALNTEENVACLQNIQHVEESVPNGV 1119
Query: 1336 ECVSDNQVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVEINLE---SKENTPPVV 1392
E V ++ T + + A VE L ++ ++ I L+ + E+ V
Sbjct: 1120 EDVLQTDDNMEICTPDRSSP----AKVEETSPLGNARLDTPDINIVLKQDMATEHPQAEV 1175
Query: 1393 ISADQMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQKKERRKEEEKPLQ 1452
+ + ++E + Q + SS + EST + + E S +K KPLQ
Sbjct: 1176 VKQESSMSESKVLGEVGKQDS---SSASLASAGESTGKKEVAEKSQINLIDKKW--KPLQ 1230
Query: 1453 K-SPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQNKKKAD---- 1507
L + + T + +G + K+ + + ++ +K A
Sbjct: 1231 GVGNLAAPNAATSSAVEVKVLTTVPEMKPQGLRIEIKSKNKVRPGSLFDEVRKTARLNRR 1290
Query: 1508 PENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKK 1567
P N +S D D S+ R+R ++ S+ S+ S S S S +
Sbjct: 1291 PRNQESSSDEQTPSRDDDSQSRSPSRSRSKSETKSRHRTRSVSYSHSRSRSRSSTSSYRS 1350
Query: 1568 RS 1569
RS
Sbjct: 1351 RS 1352
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 57.0 bits (136), Expect = 2e-07
Identities = 158/867 (18%), Positives = 308/867 (35%), Gaps = 119/867 (13%)
Query: 1244 SSTVTVKNNQETMIKTDFLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRSK 1303
S+ + E + DFL + + + +V TK R + ++ +K
Sbjct: 493 STQYNILEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQR--ADSRESLKPAAK 550
Query: 1304 PLMRSEPEKNTEESVEGIVVLEN--NPPGLLNQTECVSDNQVHLSESTMEHDNTKLKAAT 1361
PL K ++E + + + PP +V E M + +K T
Sbjct: 551 PLPSKSVRKESKEETPEVTKVNHVEKPP------------KVESKEKVMVKKDKPIKTET 598
Query: 1362 VENAVLLETNTVEEKNVEINLESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRR 1421
+ V EK V SKE PV + ++ Q T + +
Sbjct: 599 KPS--------VTEKEVP----SKEEPSPV------------KAEVAEKQATDVKPKAAK 634
Query: 1422 SEVVESTTESQDKENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEK 1481
+ V+ T+ + ++ +K++ +KE K K+P IK + PK++ + ++ +E I+K
Sbjct: 635 EKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTP--IKKEEKPKKEEVKKEVKKE--IKK 690
Query: 1482 GSNLHEKTLGETSANAETEQNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRA 1541
K ++ KK+ P+ +K E V K +K V+ + + ++
Sbjct: 691 EEKKEPK-----------KEVKKETPPKEVKKE-------VKKEEKKEVK-KEEKEPKKE 731
Query: 1542 SQGLLSSIENSESDSSEAKEEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQS 1601
+ L + S + SEAK+ + K + K + + + ++ K + IK E ++
Sbjct: 732 IKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKA 791
Query: 1602 HDYKATSEEDVSIKSPICEKQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAE 1661
+ A + + + + + ++ L+ P+DL EE K E
Sbjct: 792 AEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEE----LKAEE 847
Query: 1662 YSFTSLPVPESNLRTRNAIKRLHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHK 1721
T P+ L D L E+ + I E T E +
Sbjct: 848 VDVTKDIKPQLELIE-------------DEEKLKETEPVEAYVIQKEREVTKGPAESPDE 894
Query: 1722 RSRRVRRSKGCDCCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANP 1781
C+ E+ +P EK + +D+E E + A + + +
Sbjct: 895 GITTTEGEGECEQTPEELEPVEKQGV-------DDIEKFEDEGAGFEESSETGDYEEKAE 947
Query: 1782 YSEGQFLDEHHSVNFHLGLKEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDM 1841
E + +E + + + + T ++ +E + +ES+ SG ++ +
Sbjct: 948 TEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASG-----DDRAEE 1002
Query: 1842 DSSEAMSLESQESPNENFKTVGPCLGDSKNVSQESLETKEEKPEETPKMELSLENVTVEG 1901
D EA+ E E D ++ ++++ E +E +PE+ + + V
Sbjct: 1003 DMDEAIEKGEAEQSEEE--------ADEEDKAEDARE-EEYEPEKMEAEDYVMAVVDKAA 1053
Query: 1902 NACKVTES-NLEKAKTMELNV---GNE--ASFHGQERTKTGISEEAAIEENKRNDDSEAD 1955
A E T +L G E +S H + SE A +E R D E
Sbjct: 1054 EAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEF 1113
Query: 1956 TAKLNAKEVATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGELDGGNDV---SDLHSSE 2012
TA + E + + + +TP + + +E+T + + N S L+S E
Sbjct: 1114 TATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQE 1173
Query: 2013 ETN----TKMKNNEEMMIGEAMAETGHDGETENEGITTKTSKPDEAETNMLTAEMDNFVC 2068
+ T + E DG+ N +T + E + + + C
Sbjct: 1174 YSKPADVTPLNG-----FSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYC 1228
Query: 2069 DTVEMSTEEGIIDANKTETNTEYSKSE 2095
V+ ST I D+ ++ + S S+
Sbjct: 1229 SEVKASTTLDIKDSISAVSSEKVSPSK 1255
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform 2
[Homo sapiens]
Length = 782
Score = 57.0 bits (136), Expect = 2e-07
Identities = 79/433 (18%), Positives = 179/433 (41%), Gaps = 50/433 (11%)
Query: 1250 KNNQETMIKTDFLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKAE-QTGNKRSKPLMRS 1308
K++ + + L + K+R+ K++ +++ N R S+R E + + R + +R+
Sbjct: 5 KDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRN 64
Query: 1309 EP---EKNTEESVEGIVVLENNPPGLLNQTECVSDNQVHLSESTMEHDNTKLKAATVENA 1365
P E + E+ E L PP +++ E +VH + + + ++ + E
Sbjct: 65 SPYRREDSMEDRGEEDDSLAIKPPQQMSRKE-----KVHHRKDEKRKEKRRHRSHSAEGG 119
Query: 1366 VLLETNTVEEKNVEINLESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEVV 1425
+ V+EK E + ++ + + ++ R SRR + +
Sbjct: 120 ---KHARVKEKEREHERRKRHR--------EEQDKARREWERQKRREMAREHSRRERDRL 168
Query: 1426 ESTTESQDKENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNL 1485
E +++E +++++ + E+K ++ AE+ +E + +
Sbjct: 169 EQLERKRERERKMREQQKEQREQKERERR---------------AEERRKEREARREVSA 213
Query: 1486 HEKTLGETSANAETEQNKKKADPENIKSE---GDGTQDIVDKSSEK---LVRGRTRYQTR 1539
H +T+ E ++ + ++ P + GDG + + ++ E+ L + +
Sbjct: 214 HHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSE 273
Query: 1540 RASQGLLSSIENSESDSSEAKEEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAEN 1599
R + SS S S S E +EE ++ G +S E + +++EE+ +A
Sbjct: 274 RKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASE 333
Query: 1600 QSHDYKATSEEDVSIKSPICEKQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKY 1659
QS + SEE++S E+++E++ ++ +S D + + V E ++S
Sbjct: 334 QSAE--EVSEEEMSEDE---ERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSAL 388
Query: 1660 AEYSFTSLPVPES 1672
E + VP+S
Sbjct: 389 TEGDY----VPDS 397
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 56.2 bits (134), Expect = 4e-07
Identities = 258/1379 (18%), Positives = 523/1379 (37%), Gaps = 193/1379 (13%)
Query: 969 LETVEMME---ESSGPYSDGT-----ENSQLNVKISGMERKSNGKRDSFLAQTKNKKENM 1020
LET M+E E + SD EN QL K+ ME + + R + + + +
Sbjct: 357 LETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKK-IEELMEENMTL 415
Query: 1021 KPAAKLKLESSSLKVKGEILLEEEKSTDFVFIPPEGKDAKERILTDHQKEVLKTKRCDIP 1080
+ A K ++ S L + E LE+ T E +A ++ L E+ ++ +
Sbjct: 416 EMAQKQSMDES-LHLGWE--LEQISRTS------ELSEAPQKSLGHEVNELTSSRLLKLE 466
Query: 1081 AMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITEEQMDSDIVIPQDVTEDCG 1140
+L + + L T E + + KE+ ++ E ++++IV + ++C
Sbjct: 467 MENQSLTKTVEELRTTVDSVEG-NASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC- 524
Query: 1141 MAEHLEKSSLSNNECGSLDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSSS 1200
++L K + E L+KT E N++ + K L + + SS +S+
Sbjct: 525 --QNLSKDLMK--EKAQLEKTI-ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAE 579
Query: 1201 SVSNTTVAGTPPYPTSRRQTFITLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTD 1260
+ S ++T L K + F + K + ++ +
Sbjct: 580 ARVKDIEKENKILHESIKETSSKLSKIE------FEKRQIKKELEHYKEKGERAEELENE 633
Query: 1261 FLPKAKQREGTFSKSDSEKIV-NGTKRSSRRAGKAEQTGNKRSKPL---------MRSEP 1310
K+ E K + KI + + + E+ K K L + S
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLE 693
Query: 1311 EKNTEESVEGIVVLENNPPGLLNQTECVSDN--QVHLSESTMEHDNTKLKA------ATV 1362
++N++ E + + N + +C S Q+ L +E + +LK A+
Sbjct: 694 KENSQLDEENLELRRN-----VESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASF 748
Query: 1363 ENAVLLETN----TVEEKNVEINLESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSS 1418
+ LE + +E + ++ LE+ + S Q + ++Q + N + L+ SS
Sbjct: 749 KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQT-LQKNLEELKISS 807
Query: 1419 RRRSEVVESTTESQDKENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENL 1478
+R E +E +S ++E S +K++++ E+ ++ L +Q I + TL+EN
Sbjct: 808 -KRLEQLEKENKSLEQETSQLEKDKKQLEK----------ENKRLRQQAEIKDTTLEENN 856
Query: 1479 IEKGS-NLHEKTLG-ETSANAETEQNKKKADPENIKSEGDGTQDI-------VDKSSEKL 1529
++ G+ KTL E E+ K+ + EN + T DI D SEKL
Sbjct: 857 VKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKL 916
Query: 1530 VRGRTRYQTRRASQGLLSSIENSES--DSSEAKEEGSRKKRSGKWKNKSNESVDIQDQEE 1587
+ + + L N E ++ ++ K K ++ +S++I +EE
Sbjct: 917 KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEI--KEE 974
Query: 1588 KVVKQECIKAENQSHDYKATSEEDVSIKS--PICEKQDESNTVIC-------------QD 1632
K+ E E+ +++ + E K+ + ++QDE V +
Sbjct: 975 KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERES 1034
Query: 1633 STVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRN--------AIKRLH 1684
T +LL+V D L V E+N + AE +L L T+N A++R
Sbjct: 1035 QETTRELLKVKDRLIEV--ERNNATLQAEKQ--ALKTQLKQLETQNNNLQAQILALQRQT 1090
Query: 1685 KRDSFDNCSL-GESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQE 1743
N +L +++K+ + + + S+ T ++ ++ + + + E +
Sbjct: 1091 VSLQEQNTTLQTQNAKLQVENSTLNSQST----SLMNQNAQLLIQQSSLENENESVIKER 1146
Query: 1744 KSLIGLKNTENNDVE----ISETKKADVQAPVSPSET-SQANPYSEGQFLDEHHSVNFHL 1798
+ L L ++ D E + E + ++ ++ +S T A+ E + D N L
Sbjct: 1147 EDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLL 1206
Query: 1799 GLKEDNDTINDSLIVSETKS-KENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNE 1857
K + + L V + K EN E++ + E ++ + + L+ E
Sbjct: 1207 KQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQT 1266
Query: 1858 NFKTVGPCLGDSKNVSQESLETKEEK-PEETPKMELSLENVTVEGNACKVTESNLEKAK- 1915
+ K + L +SK + Q LE + K E+ +++++ + + + NLE+
Sbjct: 1267 DHKNLKSLLNNSK-LEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENR 1325
Query: 1916 ---------------TMELNVGNEASFHGQE----------RTKTGISEEAAIEENKRND 1950
+E N+ ++ FH ++ R + EE +++ K D
Sbjct: 1326 HLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYD 1385
Query: 1951 DSEAD------TAKLNAKEVATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGELDGGND 2004
S T K+ + ++ N + S TP + ++ + D +
Sbjct: 1386 PSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSV 1445
Query: 2005 VSD-LHSSEETNTKMKNNEEMMIGEAMAETGHDGETENEGITTKTSKPDEAETNMLTAEM 2063
S+ L + TK + ++ + G TEN + PD+ T E+
Sbjct: 1446 GSNSLEDGQTLGTKKSSTMNDLVQSMVLAGQWTGSTENLEV------PDDISTGKRRKEL 1499
Query: 2064 DNFVCDTVEMSTEEGIIDANKTETNTEYSKSEEKLDNNQMVMESDI----LQEDHHTSQK 2119
T ++ T ++ +S++ ++N DI + +D T +
Sbjct: 1500 GAMAFSTTAINF--------STVNSSAGFRSKQLVNNKDTTSFEDISPQGVSDDSSTGSR 1551
Query: 2120 V--EEPSQCLASGTAISELIIEDNNASPQKLRELDPSLVSANDSPSGMQTRCVWSPLASP 2177
V P+ + T+ S +NNAS L E+ V+ P +S
Sbjct: 1552 VHASRPASLDSGRTSTSN---SNNNAS---LHEVKAGAVNNQSRPQSH---------SSG 1596
Query: 2178 STSILKRGLKRSQEDEISSPVNKVRRVSFADPIYQAGLADDIDRRCSIVRSHSSNSSPI 2236
S+L + SSP+ ++R + + P+ Q +++ ++ R +++ S S +
Sbjct: 1597 EFSLLHD--HEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVV 1653
>gi|38788260 bromodomain PHD finger transcription factor isoform 2
[Homo sapiens]
Length = 2903
Score = 55.8 bits (133), Expect = 5e-07
Identities = 131/662 (19%), Positives = 238/662 (35%), Gaps = 103/662 (15%)
Query: 1433 DKENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGE 1492
+K++ K+ + +KP ++ P+ + DD+ + + +++ Q +++ H +
Sbjct: 1119 EKKDQDVKELLDSDSDKPCKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEGFHLR---- 1174
Query: 1493 TSANAETEQNK---------------KKADPENIKSEG--DGTQDIVDKSSEKL------ 1529
TS +T+ +K +K E IK EG G SS+ L
Sbjct: 1175 TSYKKKTKSSKLDGLLERRIKQFTLEEKQRLEKIKLEGGIKGIGKTSTNSSKNLSESPVI 1234
Query: 1530 VRGRTRYQTRRASQGLLSSIEN----------SESDSSEAK-EEGSRKKRSGKWKNKSNE 1578
+ + Q+ Q + N SESDSS + + S K++ +
Sbjct: 1235 TKAKEGCQSDSMRQEQSPNANNDQPEDLIQGCSESDSSVLRMSDPSHTTNKLYPKDRVLD 1294
Query: 1579 SVDIQDQEEKVVKQECIK-----------AENQSHDYKATSEEDVSIKSPICEKQDESNT 1627
V I+ E K KQ I+ + Q T D I D+ T
Sbjct: 1295 DVSIRSPETKCPKQNSIENDIEEKVSDLASRGQEPSKSKTKGNDFFIDDSKLASADDIGT 1354
Query: 1628 VICQ----------DSTVTSDLLQVPDDLPNVCEEKNET--SKYAEYSFTSLPVPESNLR 1675
+IC+ D+ V+S + +P +++ T S+ ++ ESN
Sbjct: 1355 LICKNKKPLIQEESDTIVSSSKSALHSSVPKSTNDRDATPLSRAMDFEGKLGCDSESNST 1414
Query: 1676 TRNAIKRLHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLE---CQHKRSRRVRRS--- 1729
N+ + +DS + + ++S IS+ E+ + LE C+
Sbjct: 1415 LENSSDTVSIQDSSEEDMIVQNSNESISEQFRTREQDVEVLEPLKCELVSGESTGNCEDR 1474
Query: 1730 ---KGCDCCGEKSQPQEK----------SLIGLKNT---ENNDVEISETKKADVQAPVSP 1773
KG + G+K Q+K I LKNT +NN+ SE K
Sbjct: 1475 LPVKGTEANGKKPSQQKKLEERPVNKCSDQIKLKNTTDKKNNENRESEKKGQRTSTFQIN 1534
Query: 1774 SETSQANPYSEGQFLDEHHSVNFHLGLKEDNDTINDSLIVSETKSKENTMQESLPSGIVN 1833
+ ++ Y +G+ L E G E N + I+ E K T++ES +N
Sbjct: 1535 GKDNKPKIYLKGECLKEISESRVVSGNVEPK-VNNINKIIPENDIKSLTVKESAIRPFIN 1593
Query: 1834 ---FREEICDMDSSEAMS-LESQESPNENFKTVGPCLGDSKNVSQESLETKEEKPEETPK 1889
E+ + +SSE S L S N++ L +K T E+
Sbjct: 1594 GDVIMEDFNERNSSETKSHLLSSSDAEGNYRDSLETLPSTKESDSTQTTTPSASCPESNS 1653
Query: 1890 MELSLENVTVEGNACKVT---------ESNLEKAKTME--LNVGNEASFHGQERTKTGIS 1938
+ +E++ +E + K ESNL E L + + +G+ + KT I+
Sbjct: 1654 VN-QVEDMEIETSEVKKVTSSPITSEEESNLSNDFIDENGLPINKNENVNGESKRKTVIT 1712
Query: 1939 EEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGE 1998
E + + + K+ +S + + +T T++S + G
Sbjct: 1713 EVTTMTSTVATESKTVIKVEKGDKQTVV---SSTENCAKSTVTTTTTTVTKLSTPSTGGS 1769
Query: 1999 LD 2000
+D
Sbjct: 1770 VD 1771
Score = 39.7 bits (91), Expect = 0.037
Identities = 46/211 (21%), Positives = 92/211 (43%), Gaps = 16/211 (7%)
Query: 1816 TKSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTVGPCLGDSKNVSQE 1875
T+ N + S S + EEI + ++ +++ +SP E K DSK+ +++
Sbjct: 534 TEDLTNKARGSNKSFLAAANEEILESIRAKKGDIDNVKSPEETEKDKNETENDSKD-AEK 592
Query: 1876 SLETKEEKPEETPKMELSLENVTVEGNACKVTESNLEKAKTMELNVGNEASFHGQERTKT 1935
+ E E++ E + + ++ +G + + TE +K ++ N+G + T
Sbjct: 593 NREEFEDQSLEKDSDDKTPDDDPEQGKSEEPTEVG-DKGNSVSANLG--------DNTTN 643
Query: 1936 GISEEAAIEENKRND---DSEADTAKLNAKEVATEEFNSDISLSDNTTPVKLNAQTEISE 1992
SEE + E + D++ + K+VA+ E D+ N T N T +
Sbjct: 644 ATSEETSPSEGRSPVGCLSETPDSSNMAEKKVAS-ELPQDVPEEPNKTCESSN--TSATT 700
Query: 1993 QTAAGELDGGNDVSDLHSSEETNTKMKNNEE 2023
+ L+ N S+L+SS+ + K ++ E
Sbjct: 701 TSIQPNLENSNSSSELNSSQSESAKAADDPE 731
Score = 39.3 bits (90), Expect = 0.049
Identities = 140/791 (17%), Positives = 284/791 (35%), Gaps = 127/791 (16%)
Query: 1465 KQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQNKKKADPENIKS--EGDGTQDIV 1522
++++ + E+L K ++ L + KK D +N+KS E + ++
Sbjct: 524 REEIHRHMDITEDLTNKARGSNKSFLAAANEEILESIRAKKGDIDNVKSPEETEKDKNET 583
Query: 1523 DKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSS--EAKEEGSRKKRSGKWKNKSNESV 1580
+ S+ + R ++ + S+E D + + E+G ++ + ++ S
Sbjct: 584 ENDSKDAEKNREEFEDQ--------SLEKDSDDKTPDDDPEQGKSEEPTEVGDKGNSVSA 635
Query: 1581 DIQDQEEKVVKQECIKAENQS--------HDYKATSEEDVSIKSPICEKQDESNTVICQD 1632
++ D +E +E +S D +E+ V+ + P ++ + T C+
Sbjct: 636 NLGDNTTNATSEETSPSEGRSPVGCLSETPDSSNMAEKKVASELPQDVPEEPNKT--CES 693
Query: 1633 STVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKRLHK------R 1686
S ++ + +L N S +E S + PE+ R + + + +
Sbjct: 694 SNTSATTTSIQPNLENSNSSSELNSSQSE-SAKAADDPENGERESHTPVSIQEEIVGDFK 752
Query: 1687 DSFDNCSLGESSKIG-------------ISDISSLSE-KTFQTLECQHKRSRRVRRSKG- 1731
N L ES G + S LS+ K+ Q H+ ++ + K
Sbjct: 753 SEKSNGELSESPGAGKGASGSTRIITRLRNPDSKLSQLKSQQVAAAAHEANKLFKEGKEV 812
Query: 1732 --CDCCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQF-L 1788
+ GE S+ K + +K NN ++ + K V N YS F L
Sbjct: 813 LVVNSQGEISRLSTKKEVIMKGNINNYFKLGQEGKYRV----------YHNQYSTNSFAL 862
Query: 1789 DEH-----HSVNFHLGLK---------EDNDTINDS--LIVSETKSKENTMQESLPSGIV 1832
++H H HL K + N +++ S L +S + ++ ++PS +
Sbjct: 863 NKHQHREDHDKRRHLAHKFCLTPAGEFKWNGSVHGSKVLTISTLRLTITQLENNIPSSFL 922
Query: 1833 N-----------FREEICDMDSSEAMS---LESQESPNENFKTVGPCLGDSKNVSQESLE 1878
+ ++C A++ LE P LG ++ S+E
Sbjct: 923 HPNWASHRANWIKAVQMCSKPREFALALAILECAVKPVVMLPIWRESLGHTRLHRMTSIE 982
Query: 1879 TKEEKPEETPKMELSLENVTVEGNACKVT---ESNLEKAKTMELNVGNEASFHGQERT-- 1933
+E++ + + + E + K T + + K K E V + +T
Sbjct: 983 REEKEKVKKKEKKQEEEETMQQATWVKYTFPVKHQVWKQKGEEYRVTGYGGWSWISKTHV 1042
Query: 1934 ---------KTGISEEAAIEENKRNDDSEADTA------------KLNAKEVATEEFNSD 1972
T ++ ++E K N D D + K+ E SD
Sbjct: 1043 YRFVPKLPGNTNVNYRKSLEGTKNNMDENMDESDKRKCSRSPKKIKIEPDSEKDEVKGSD 1102
Query: 1973 ISLSDNTTPVKLNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKMKNNEEMMIGEAMAE 2032
+ + + ++ TE +Q LD +D E + MK + E+
Sbjct: 1103 AAKGADQNEMDISKITEKKDQDVKELLDSDSDKPCKEEPMEVDDDMKTESHVNCQES--- 1159
Query: 2033 TGHDGETENEGITTKTSKPDEAETNMLTAEMDNFVCD-TVE-------MSTEEGIIDANK 2084
+ D +EG +TS + +++ L ++ + T+E + E GI K
Sbjct: 1160 SQVDVVNVSEGFHLRTSYKKKTKSSKLDGLLERRIKQFTLEEKQRLEKIKLEGGIKGIGK 1219
Query: 2085 TETNTEYSKSEEK-LDNNQMVMESDILQEDHHTSQKVEEPSQCL--ASGTAISELIIEDN 2141
T TN+ + SE + + +SD ++++ + ++P + S + S L + D
Sbjct: 1220 TSTNSSKNLSESPVITKAKEGCQSDSMRQEQSPNANNDQPEDLIQGCSESDSSVLRMSDP 1279
Query: 2142 NASPQKLRELD 2152
+ + KL D
Sbjct: 1280 SHTTNKLYPKD 1290
Score = 36.2 bits (82), Expect = 0.41
Identities = 92/484 (19%), Positives = 187/484 (38%), Gaps = 52/484 (10%)
Query: 1817 KSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTVGPCLGDSKNVSQES 1876
K+ N+ + S ++ +E C DS + ++SPN N + S S
Sbjct: 1219 KTSTNSSKNLSESPVITKAKEGCQSDS-----MRQEQSPNANNDQPEDLIQGCSE-SDSS 1272
Query: 1877 LETKEEKPEETPKM---ELSLENVTVEGNACKVTESNLEKAKTMELNVGNEASFHGQERT 1933
+ + T K+ + L++V++ K + N + +E V + AS GQE +
Sbjct: 1273 VLRMSDPSHTTNKLYPKDRVLDDVSIRSPETKCPKQNSIE-NDIEEKVSDLAS-RGQEPS 1330
Query: 1934 KTGIS-EEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTTPVKLNAQTEISE 1992
K+ + I+++K + T K+ +E SD +S + + + + ++
Sbjct: 1331 KSKTKGNDFFIDDSKLASADDIGTLICKNKKPLIQE-ESDTIVSSSKSALHSSVPKSTND 1389
Query: 1993 QTAAGELDGGNDVSDLHSSEETNTKMKNNEEMMIGEAMAETGHDGETENEGITTKTSKPD 2052
+ A + L E+N+ ++N+ + + + +E + NE I+ + +
Sbjct: 1390 RDATPLSRAMDFEGKLGCDSESNSTLENSSDTVSIQDSSEEDMIVQNSNESISEQF-RTR 1448
Query: 2053 EAETNMLTAEMDNFVCDTVEMSTE---EGIIDANKTETNTEYSKSEEKLDNNQMVMESDI 2109
E + +L + C+ V + E + TE N + ++KL+ + SD
Sbjct: 1449 EQDVEVL----EPLKCELVSGESTGNCEDRLPVKGTEANGKKPSQQKKLEERPVNKCSDQ 1504
Query: 2110 LQEDHHTSQKVEEPSQCLASGTAISELIIEDNNASP------QKLRELDPS-LVSANDSP 2162
++ + T +K E + G S I + P + L+E+ S +VS N
Sbjct: 1505 IKLKNTTDKKNNENRESEKKGQRTSTFQINGKDNKPKIYLKGECLKEISESRVVSGN--- 1561
Query: 2163 SGMQTRCVWSPLASPSTSILKRGLKRSQEDEISSPVNKVRRVSFADPIYQAGLADDIDRR 2222
P + + + + + ++ + +R D I + D +R
Sbjct: 1562 ------------VEPKVNNINKIIPENDIKSLTVKESAIRPFINGDVI----MEDFNERN 1605
Query: 2223 CSIVRSHSSNSSP----IGKSVKTSPTTQSKHNT-TSAKGFLSPGSRSPKFKSSKKCLIS 2277
S +SH +SS S++T P+T+ +T T+ P S S + S
Sbjct: 1606 SSETKSHLLSSSDAEGNYRDSLETLPSTKESDSTQTTTPSASCPESNSVNQVEDMEIETS 1665
Query: 2278 EMAK 2281
E+ K
Sbjct: 1666 EVKK 1669
Score = 32.0 bits (71), Expect = 7.8
Identities = 64/355 (18%), Positives = 119/355 (33%), Gaps = 60/355 (16%)
Query: 1084 NNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITEEQMDSDIVIPQDVTEDCGMAE 1143
+ L+ S DT+ Q S EE M + E + T EQ D + E
Sbjct: 1413 STLENSSDTVSIQDSSEEDMIVQNSNESISEQFR---TREQ-------------DVEVLE 1456
Query: 1144 HLEKSSLSNNECGSLDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSSSSVS 1203
L+ +S G+ + P N ++ +K + + + +++
Sbjct: 1457 PLKCELVSGESTGNCEDRLPVKGTEANGKKPS---QQKKLEERPVNKCSDQIKLKNTTDK 1513
Query: 1204 NTTVAGTPPYPTSRRQTFITLEKFDGSENRP---FSPSPLNNISSTVTVKNNQETMIKT- 1259
R TF + +G +N+P L IS + V N E +
Sbjct: 1514 KNNENRESEKKGQRTSTF----QINGKDNKPKIYLKGECLKEISESRVVSGNVEPKVNNI 1569
Query: 1260 -DFLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESV 1318
+P+ + T +S +NG + +S L S+ E N +S+
Sbjct: 1570 NKIIPENDIKSLTVKESAIRPFINGDV--IMEDFNERNSSETKSHLLSSSDAEGNYRDSL 1627
Query: 1319 EGIVVLENNPPGLLNQTECVSDNQVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNV 1378
E + ST E D+T+ + N VE+ +
Sbjct: 1628 ETL-------------------------PSTKESDSTQTTTPSASCPESNSVNQVEDMEI 1662
Query: 1379 EINLESKENTPPVVISADQMVNED----SQVQITPNQKTLRRSSRRRSEVVESTT 1429
E + K + P+ + ++ D + + I N+ + S+R++ + E TT
Sbjct: 1663 ETSEVKKVTSSPITSEEESNLSNDFIDENGLPINKNE-NVNGESKRKTVITEVTT 1716
>gi|38788274 bromodomain PHD finger transcription factor isoform 1
[Homo sapiens]
Length = 2920
Score = 55.8 bits (133), Expect = 5e-07
Identities = 131/662 (19%), Positives = 238/662 (35%), Gaps = 103/662 (15%)
Query: 1433 DKENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGE 1492
+K++ K+ + +KP ++ P+ + DD+ + + +++ Q +++ H +
Sbjct: 993 EKKDQDVKELLDSDSDKPCKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEGFHLR---- 1048
Query: 1493 TSANAETEQNK---------------KKADPENIKSEG--DGTQDIVDKSSEKL------ 1529
TS +T+ +K +K E IK EG G SS+ L
Sbjct: 1049 TSYKKKTKSSKLDGLLERRIKQFTLEEKQRLEKIKLEGGIKGIGKTSTNSSKNLSESPVI 1108
Query: 1530 VRGRTRYQTRRASQGLLSSIEN----------SESDSSEAK-EEGSRKKRSGKWKNKSNE 1578
+ + Q+ Q + N SESDSS + + S K++ +
Sbjct: 1109 TKAKEGCQSDSMRQEQSPNANNDQPEDLIQGCSESDSSVLRMSDPSHTTNKLYPKDRVLD 1168
Query: 1579 SVDIQDQEEKVVKQECIK-----------AENQSHDYKATSEEDVSIKSPICEKQDESNT 1627
V I+ E K KQ I+ + Q T D I D+ T
Sbjct: 1169 DVSIRSPETKCPKQNSIENDIEEKVSDLASRGQEPSKSKTKGNDFFIDDSKLASADDIGT 1228
Query: 1628 VICQ----------DSTVTSDLLQVPDDLPNVCEEKNET--SKYAEYSFTSLPVPESNLR 1675
+IC+ D+ V+S + +P +++ T S+ ++ ESN
Sbjct: 1229 LICKNKKPLIQEESDTIVSSSKSALHSSVPKSTNDRDATPLSRAMDFEGKLGCDSESNST 1288
Query: 1676 TRNAIKRLHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLE---CQHKRSRRVRRS--- 1729
N+ + +DS + + ++S IS+ E+ + LE C+
Sbjct: 1289 LENSSDTVSIQDSSEEDMIVQNSNESISEQFRTREQDVEVLEPLKCELVSGESTGNCEDR 1348
Query: 1730 ---KGCDCCGEKSQPQEK----------SLIGLKNT---ENNDVEISETKKADVQAPVSP 1773
KG + G+K Q+K I LKNT +NN+ SE K
Sbjct: 1349 LPVKGTEANGKKPSQQKKLEERPVNKCSDQIKLKNTTDKKNNENRESEKKGQRTSTFQIN 1408
Query: 1774 SETSQANPYSEGQFLDEHHSVNFHLGLKEDNDTINDSLIVSETKSKENTMQESLPSGIVN 1833
+ ++ Y +G+ L E G E N + I+ E K T++ES +N
Sbjct: 1409 GKDNKPKIYLKGECLKEISESRVVSGNVEPK-VNNINKIIPENDIKSLTVKESAIRPFIN 1467
Query: 1834 ---FREEICDMDSSEAMS-LESQESPNENFKTVGPCLGDSKNVSQESLETKEEKPEETPK 1889
E+ + +SSE S L S N++ L +K T E+
Sbjct: 1468 GDVIMEDFNERNSSETKSHLLSSSDAEGNYRDSLETLPSTKESDSTQTTTPSASCPESNS 1527
Query: 1890 MELSLENVTVEGNACKVT---------ESNLEKAKTME--LNVGNEASFHGQERTKTGIS 1938
+ +E++ +E + K ESNL E L + + +G+ + KT I+
Sbjct: 1528 VN-QVEDMEIETSEVKKVTSSPITSEEESNLSNDFIDENGLPINKNENVNGESKRKTVIT 1586
Query: 1939 EEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGE 1998
E + + + K+ +S + + +T T++S + G
Sbjct: 1587 EVTTMTSTVATESKTVIKVEKGDKQTVV---SSTENCAKSTVTTTTTTVTKLSTPSTGGS 1643
Query: 1999 LD 2000
+D
Sbjct: 1644 VD 1645
Score = 36.2 bits (82), Expect = 0.41
Identities = 92/484 (19%), Positives = 187/484 (38%), Gaps = 52/484 (10%)
Query: 1817 KSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTVGPCLGDSKNVSQES 1876
K+ N+ + S ++ +E C DS + ++SPN N + S S
Sbjct: 1093 KTSTNSSKNLSESPVITKAKEGCQSDS-----MRQEQSPNANNDQPEDLIQGCSE-SDSS 1146
Query: 1877 LETKEEKPEETPKM---ELSLENVTVEGNACKVTESNLEKAKTMELNVGNEASFHGQERT 1933
+ + T K+ + L++V++ K + N + +E V + AS GQE +
Sbjct: 1147 VLRMSDPSHTTNKLYPKDRVLDDVSIRSPETKCPKQNSIE-NDIEEKVSDLAS-RGQEPS 1204
Query: 1934 KTGIS-EEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTTPVKLNAQTEISE 1992
K+ + I+++K + T K+ +E SD +S + + + + ++
Sbjct: 1205 KSKTKGNDFFIDDSKLASADDIGTLICKNKKPLIQE-ESDTIVSSSKSALHSSVPKSTND 1263
Query: 1993 QTAAGELDGGNDVSDLHSSEETNTKMKNNEEMMIGEAMAETGHDGETENEGITTKTSKPD 2052
+ A + L E+N+ ++N+ + + + +E + NE I+ + +
Sbjct: 1264 RDATPLSRAMDFEGKLGCDSESNSTLENSSDTVSIQDSSEEDMIVQNSNESISEQF-RTR 1322
Query: 2053 EAETNMLTAEMDNFVCDTVEMSTE---EGIIDANKTETNTEYSKSEEKLDNNQMVMESDI 2109
E + +L + C+ V + E + TE N + ++KL+ + SD
Sbjct: 1323 EQDVEVL----EPLKCELVSGESTGNCEDRLPVKGTEANGKKPSQQKKLEERPVNKCSDQ 1378
Query: 2110 LQEDHHTSQKVEEPSQCLASGTAISELIIEDNNASP------QKLRELDPS-LVSANDSP 2162
++ + T +K E + G S I + P + L+E+ S +VS N
Sbjct: 1379 IKLKNTTDKKNNENRESEKKGQRTSTFQINGKDNKPKIYLKGECLKEISESRVVSGN--- 1435
Query: 2163 SGMQTRCVWSPLASPSTSILKRGLKRSQEDEISSPVNKVRRVSFADPIYQAGLADDIDRR 2222
P + + + + + ++ + +R D I + D +R
Sbjct: 1436 ------------VEPKVNNINKIIPENDIKSLTVKESAIRPFINGDVI----MEDFNERN 1479
Query: 2223 CSIVRSHSSNSSP----IGKSVKTSPTTQSKHNT-TSAKGFLSPGSRSPKFKSSKKCLIS 2277
S +SH +SS S++T P+T+ +T T+ P S S + S
Sbjct: 1480 SSETKSHLLSSSDAEGNYRDSLETLPSTKESDSTQTTTPSASCPESNSVNQVEDMEIETS 1539
Query: 2278 EMAK 2281
E+ K
Sbjct: 1540 EVKK 1543
Score = 32.0 bits (71), Expect = 7.8
Identities = 64/355 (18%), Positives = 119/355 (33%), Gaps = 60/355 (16%)
Query: 1084 NNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITEEQMDSDIVIPQDVTEDCGMAE 1143
+ L+ S DT+ Q S EE M + E + T EQ D + E
Sbjct: 1287 STLENSSDTVSIQDSSEEDMIVQNSNESISEQFR---TREQ-------------DVEVLE 1330
Query: 1144 HLEKSSLSNNECGSLDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSSSSVS 1203
L+ +S G+ + P N ++ +K + + + +++
Sbjct: 1331 PLKCELVSGESTGNCEDRLPVKGTEANGKKPS---QQKKLEERPVNKCSDQIKLKNTTDK 1387
Query: 1204 NTTVAGTPPYPTSRRQTFITLEKFDGSENRP---FSPSPLNNISSTVTVKNNQETMIKT- 1259
R TF + +G +N+P L IS + V N E +
Sbjct: 1388 KNNENRESEKKGQRTSTF----QINGKDNKPKIYLKGECLKEISESRVVSGNVEPKVNNI 1443
Query: 1260 -DFLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESV 1318
+P+ + T +S +NG + +S L S+ E N +S+
Sbjct: 1444 NKIIPENDIKSLTVKESAIRPFINGDV--IMEDFNERNSSETKSHLLSSSDAEGNYRDSL 1501
Query: 1319 EGIVVLENNPPGLLNQTECVSDNQVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNV 1378
E + ST E D+T+ + N VE+ +
Sbjct: 1502 ETL-------------------------PSTKESDSTQTTTPSASCPESNSVNQVEDMEI 1536
Query: 1379 EINLESKENTPPVVISADQMVNED----SQVQITPNQKTLRRSSRRRSEVVESTT 1429
E + K + P+ + ++ D + + I N+ + S+R++ + E TT
Sbjct: 1537 ETSEVKKVTSSPITSEEESNLSNDFIDENGLPINKNE-NVNGESKRKTVITEVTT 1590
>gi|21735569 claspin [Homo sapiens]
Length = 1339
Score = 55.5 bits (132), Expect = 7e-07
Identities = 158/828 (19%), Positives = 316/828 (38%), Gaps = 87/828 (10%)
Query: 1464 PKQKLIAEQTLQENLIEKGSNLHEKTLGETSANA-ETEQNKKKADPENIKSEGDGTQDIV 1522
P K A QT+ N+I K K E A+ KK D + G+ Q +
Sbjct: 541 PAAKPRAGQTVNVNVIVKDMGTDGKE--ELKADVVPVTLAPKKLDGASHTKPGEKLQVLK 598
Query: 1523 DKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWKNKSNESVDI 1582
K E + R + +R + L + + E + E +E + G+ K + E +
Sbjct: 599 AKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEE 658
Query: 1583 QDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDESNTVICQDSTVTSDLLQV 1642
++EE+ ++E + ++ ++ +SEE I++ ++ D+ N + L V
Sbjct: 659 LEEEEEKEEEEEEEGNQETAEFLLSSEE---IETKDEKEMDKENNDGSSEIGKAVGFLSV 715
Query: 1643 PDDLPN---VCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKRLHKRDSFDNCSL--GES 1697
P L + + K+ +SK + P E + N+ K+ K D D+CSL ES
Sbjct: 716 PKSLSSDSTLLLFKDSSSKMGYF-----PTEEKSETDENSGKQPSKLDEDDSCSLLTKES 770
Query: 1698 SKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQEKSLIGLKNTENNDV 1757
S ++ + ++Q Q R + G G +S L ++ +
Sbjct: 771 SHNSSFELIGSTIPSYQPCNRQTGRGTSFFPTAG----GFRSPSPGLFRASLVSSASK-- 824
Query: 1758 EISETKKADVQAPVSPS-ETSQANPYSEGQFLDEHHSVNFHLGLKEDNDT----INDSLI 1812
S K ++ P+ S + A+P + FL + +F L++D + + L
Sbjct: 825 --SSGKLSEPSLPIEDSQDLYNASPEPKTLFLG---AGDFQFCLEDDTQSQLLDADGFLN 879
Query: 1813 VSETKSKENTMQESLPSGIVNFR------EEICDMDSSEAMSLESQESPNENFK------ 1860
V +++ ++ LP ++ +E+ D+ + + S + P ++ K
Sbjct: 880 VRNHRNQYQALKPRLPLASMDENAMDANMDELLDLCTGKFTSQAEKHLPRKSDKKENMEE 939
Query: 1861 TVGPCLG-----DSKNVSQESLETKEEKPEETPKMELSLENVTVEGNACKVTESNLEKAK 1915
+ C G D+ + L +E++ ME +L + K E E+
Sbjct: 940 LLNLCSGKFTSQDASTPASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFG 999
Query: 1916 TMELNVGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAK-----------EV 1964
L V N+ F E + + A+E+++ DD E + K + K E
Sbjct: 1000 DFRL-VSNDNEFDSDEDEHSDSGNDLALEDHE--DDDEEELLKRSEKLKRQMRLRKYLED 1056
Query: 1965 ATEEFNSDISLSDNTTPVKLNA-QTEISEQTAAGELDGGNDVSDLHSS---EETNTKMKN 2020
E SD+ D +++ + ++ ++ + + + + +H ++ +++
Sbjct: 1057 EAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRL 1116
Query: 2021 NEEMMIGEAMAETGHDGETENEGITTKTSKPDEAETNMLTAEMDNFVCDTVEMSTEEGII 2080
+E + + + G + D+A ++MD F D+ + TEE +
Sbjct: 1117 YQERYLADGDLHSDGPGRMRK----FRWKNIDDA------SQMDLFHRDSDDDQTEEQ-L 1165
Query: 2081 DANKTETNTEYSKSEEKLDNNQMVMESDILQEDHHTSQKVEEPSQCLASGTAISELIIED 2140
D ++ E + E+ L M + I E+ +++ E SQ + ++ ++
Sbjct: 1166 DESEARWRKERIEREQWL--RDMAQQGKITAEE---EEEIGEDSQFMILAKKVTAKALQK 1220
Query: 2141 NNASPQKLRELDPSLVSANDS--PSGMQTRCVWSPLASPSTSILKRGLKRSQEDEISSPV 2198
N + P ++E L + ++ P Q S L P + K L + S+P
Sbjct: 1221 NASRPMVIQESKSLLRNPFEAIRPGSAQQVKTGSLLNQPKAVLQK--LAALSDHNPSAPR 1278
Query: 2199 NKVRRVSFADPIYQAGLADDIDRRCSIVRSHSSNSSPIGKSVKTSPTT 2246
N V +A A + + R S +SP K +KT +T
Sbjct: 1279 NSRNFVFHTLSPVKAEAAKESSKSQVKKRGPSFMTSPSPKHLKTDDST 1326
Score = 34.7 bits (78), Expect = 1.2
Identities = 55/313 (17%), Positives = 115/313 (36%), Gaps = 40/313 (12%)
Query: 1966 TEEFNSDISLSDNTTPVKLNAQTEISEQTAAGELDGGNDVSDLHSSEE--TNTKMKNNEE 2023
T E S++ L N V + + + G + +S+ S EE + K+KN
Sbjct: 2 TGEVGSEVHLEINDPNVISQEEADSPSDSGQGSYETIGPLSEGDSDEEIFVSKKLKNR-- 59
Query: 2024 MMIGEAMAETGHDGETENEGITTKTSKPDEAETNMLTAEMDNFVCDTVEMSTEEGIIDAN 2083
K + ++ET A + D+ E +E +
Sbjct: 60 -----------------------KVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGK 96
Query: 2084 KTETNTEYSKSEEKLDNNQMVMESDILQEDHHTSQKVEEPSQCLASGTAISELIIEDNNA 2143
T+ Y + D+++ ME + QE+ K P L+ + S D +
Sbjct: 97 NTKIKRIY---KTVADSDESYMEKSLYQENLEAQVK---PCLELSLQSGNSTDFTTDRKS 150
Query: 2144 SPQKLRELDPSLVSANDSPSGMQTRCVWSPLASPSTSILKRGLKRSQEDEISSPVNKVRR 2203
S + + + + + A + + R LK+ ++QED++ P N
Sbjct: 151 SKKHIHDKEGT---AGKAKVKSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQPFNDSGC 207
Query: 2204 VSFADPIYQAGLADD----IDRRCSIVRSHSSNSSPIGKSVKTSPTTQSKHNTTSAKGFL 2259
+ +++ GL D+ ++ S+ ++ + + K K P+ +S ++ L
Sbjct: 208 LLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEEGSEL 267
Query: 2260 SPGSRSPKFKSSK 2272
S G+ + K+++
Sbjct: 268 SKGTTRKERKAAR 280
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 54.7 bits (130), Expect = 1e-06
Identities = 70/371 (18%), Positives = 150/371 (40%), Gaps = 52/371 (14%)
Query: 1333 NQTECVSDNQVHLSESTMEHDNTKLK----AATVENAVLLETNTVEEKNVEINLESKENT 1388
+Q E + N V E+ NT+++ AA +E E +K ++ LE ++
Sbjct: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREER--RQKRLQEALERQKEF 121
Query: 1389 PPVVISAD------QMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQKKE 1442
P + A +M N+ ++ + T ++ S + R E+ E+ T ++ S+QK +
Sbjct: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEK-SESRQERYEIEETETVTK----SYQKND 176
Query: 1443 RRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAE---- 1498
R EE + +++ PK+ I E ++ + EK + E+T+ + N +
Sbjct: 177 WRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSE 236
Query: 1499 ---------------------TEQNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQ 1537
E++K++A+ E + E + + I + +K+ R R +
Sbjct: 237 EPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIE 296
Query: 1538 T----------RRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWKNKSNESVDIQDQEE 1587
RR ++ E + + E + +KR+ + + + E +E
Sbjct: 297 AEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEER 356
Query: 1588 KVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDESNTVICQDSTVTSDLLQVPDDLP 1647
+ +K+E +A + +A EE ++ KQ E Q++ + + ++ +
Sbjct: 357 QRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGK 416
Query: 1648 NVCEEKNETSK 1658
V E+K + K
Sbjct: 417 WVNEKKAQEDK 427
Score = 48.5 bits (114), Expect = 8e-05
Identities = 89/420 (21%), Positives = 155/420 (36%), Gaps = 58/420 (13%)
Query: 1717 ECQHKRSRRVRRSKGCDCCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQAPVSPSET 1776
E +R RR R+ + Q QE+ +G + VE++ + + +
Sbjct: 36 EAARERRRRARQER-------LRQKQEEESLG---QVTDQVEVNAQNSVPDEEAKTTTTN 85
Query: 1777 SQANPYSEGQFLD------EHHSVNFHLGL---KEDNDTINDSLIVSETKSKENTMQESL 1827
+Q E FL+ E L KE + TI D+ + ++ +N E+
Sbjct: 86 TQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENE 145
Query: 1828 PSGIVNFREEICDMDSSEAMSLESQESPNENF-KTVGPCLGDSKNVSQESLETKEEKPEE 1886
+ +E E +E E+ +++ K ++K +E E +EEKP+
Sbjct: 146 TT-----EKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKR 200
Query: 1887 TPKMELSLENVTVEGNACKVTESNLEKAKTMELNVGNEASFHG-QERTKTGISEEAAIEE 1945
E +E + E K TES E+ M L G +S QE + S+E + E
Sbjct: 201 GSIGENQVEVMVEE----KTTESQ-EETVVMSLKNGQISSEEPKQEEEREQGSDEISHHE 255
Query: 1946 NKRNDD---SEADTAKLNAKEVATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGELDGG 2002
+D +EA+ A+L A+E + D ++D A+ E E+ AA E +
Sbjct: 256 KMEEEDKERAEAERARLEAEERERIKAEQDKKIADE------RARIEAEEKAAAQERE-- 307
Query: 2003 NDVSDLHSSEETNTKMKNNEEMMIGEAMAETGHDGETENEGITTKTSKPDEAETNMLTAE 2062
E +M+ E+ E + E K + AE E
Sbjct: 308 ------RREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKE 361
Query: 2063 MDNFVCDTVEMSTEEGIIDANKTETNTEYSKSEEKLDNNQMVMESDILQEDHHTSQKVEE 2122
+ + + + E E +K EE+ N Q+ + +QE +KVE+
Sbjct: 362 EEKRAAEERQRARAE----------EEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQ 411
Score = 35.0 bits (79), Expect = 0.92
Identities = 81/451 (17%), Positives = 164/451 (36%), Gaps = 52/451 (11%)
Query: 1264 KAKQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRS---KPLMRSEPEKNTEESVEG 1320
+A++RE ++ D +KI + R A Q +R + MR E ++ EE
Sbjct: 273 EAEERERIKAEQD-KKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQR- 330
Query: 1321 IVVLENNPPGLLNQTECVSDNQVHLSESTMEHDNTKLKAATVENAVLLETNT---VEEKN 1377
++ + + + + + +E + +AA E VEE+
Sbjct: 331 ---IKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQK 387
Query: 1378 VEINLESKENT-PPVVISADQM--------VNEDSQVQITPNQKTLRRSSRRRSEVVEST 1428
LE K++ I +++ VNE + L++ + V++
Sbjct: 388 RNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAK 447
Query: 1429 TESQDKENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLH-E 1487
E ++ KKE K+E+ K P + ++K E Q H E
Sbjct: 448 REKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTE 507
Query: 1488 KTLGETSANAETEQNKKKADPE-------------NIKSEGDGTQDIVDKSSEKLVRGRT 1534
T A + + + P+ ++E + + + K E +
Sbjct: 508 NTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEE 567
Query: 1535 RYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQEC 1594
+ R + +L E + +EE RK R + K + E ++ + + E K++
Sbjct: 568 LKKKREERRKVL-----EEEEQRRKQEEADRKLREEEEKRRLKEEIE-RRRAEAAEKRQK 621
Query: 1595 IKAENQSHD---YKATSEEDVSIKSPICEKQDESNTVICQDSTVTSD-----LLQVPDDL 1646
+ + S D +K + + S+K I E+ + N + + S V S + ++ L
Sbjct: 622 MPEDGLSDDKKPFKCFTPKGSSLK--IEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRL 679
Query: 1647 PNVCE--EKNETSKYAEYSFTSLPVPESNLR 1675
E +++K + + + LPVP +R
Sbjct: 680 EQYTSAIEGTKSAKPTKPAASDLPVPAEGVR 710
Score = 34.7 bits (78), Expect = 1.2
Identities = 89/484 (18%), Positives = 183/484 (37%), Gaps = 36/484 (7%)
Query: 1416 RSSRRRSEVVESTTESQDKENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQ 1475
R + +R++ E + + + Q++ R+K+EE+ L + ++ + +T
Sbjct: 24 RIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 83
Query: 1476 ENLIEKGSNLHEKTLGETSANAETEQNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTR 1535
N +G + E E A E + K+ + + E D T I D S
Sbjct: 84 TNTQVEGDD--EAAFLERLARREERRQKRLQEALERQKEFDPT--ITDAS--------LS 131
Query: 1536 YQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECI 1595
+RR + + + SE+++E + + + KS + D +D EE K++
Sbjct: 132 LPSRRMQNDTAENETTEKEEKSESRQERYEIEET-ETVTKSYQKNDWRDAEEN-KKEDKE 189
Query: 1596 KAENQSHDYKATSEEDVSIKSPICEKQDESNTVICQDSTVTSDLL--QVPDDLPNVCEEK 1653
K E + K S + ++ + EK ES Q+ TV L Q+ + P EE+
Sbjct: 190 KEEEEEEKPKRGSIGENQVEVMVEEKTTES-----QEETVVMSLKNGQISSEEPKQEEER 244
Query: 1654 ----NETSKYAEYSFTSLPVPESNLRTRNAIKRLHKRDSFDNCSLGESSKIGISDISSLS 1709
+E S + + E+ A +R + D E ++I + ++
Sbjct: 245 EQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQ 304
Query: 1710 EKTFQTLECQHK-RSRRVRRSKGCDCCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQ 1768
E+ + E + + R R ++ E+ + + +K E E E ++ +
Sbjct: 305 ERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE--ERQRIKEE 362
Query: 1769 APVSPSETSQANPYSEGQFLDEHHSVNFHLGLKEDNDTINDSLIVSETKSKENTMQESLP 1828
+ E +A E + E N L K+ + ETK K +++ +
Sbjct: 363 EKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKH--------AMQETKIKGEKVEQKIE 414
Query: 1829 SGIVNFREEICDMDSSEAMSLESQESPNENFKTVGPCLGDSKNVSQESLETKEEKPEETP 1888
VN ++ D + + + +E + D +E ++ ++ K ++ P
Sbjct: 415 GKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474
Query: 1889 KMEL 1892
K E+
Sbjct: 475 KEEV 478
Score = 32.7 bits (73), Expect = 4.5
Identities = 74/420 (17%), Positives = 142/420 (33%), Gaps = 48/420 (11%)
Query: 1583 QDQEEKVVKQECIKAENQSHDYKATSEEDV--SIKSPICEKQDESNTVICQDSTVTSDLL 1640
Q +EE ++ E I + D + + E + + + +KQ+E + D +
Sbjct: 13 QKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQN 72
Query: 1641 QVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKRLHKRDSFDNCSLGESSKI 1700
VPD+ + E +F R + + L ++ FD
Sbjct: 73 SVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT-------- 124
Query: 1701 GISDIS-SLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQEKSLIGLKNTENNDVEI 1759
I+D S SL + Q +++ + + +S+ E+ + +E + +N+ +
Sbjct: 125 -ITDASLSLPSRRMQNDTAENETTEKEEKSESRQ---ERYEIEETETVTKSYQKNDWRDA 180
Query: 1760 SETKKADVQAPVSPSETSQANPYSEGQ---FLDEHHSVNFHLGLKEDNDTINDSLIVSET 1816
E KK D + E + E Q ++E + + +T+ SL +
Sbjct: 181 EENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTT-------ESQEETVVMSLKNGQI 233
Query: 1817 KSKENTMQESLPSGI------VNFREEICDMDSSEAMSLESQESPNENFKTVGPCLGDSK 1870
S+E +E G EE + +E LE++E + +
Sbjct: 234 SSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERA 293
Query: 1871 NVSQESLETKEEKP----EETPKMELSLENVTVEGNACKVTESNL-----------EKAK 1915
+ E +E+ EE +M + E K E ++A
Sbjct: 294 RIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAA 353
Query: 1916 TMELNVGNEASFHGQERTKTGISEE--AAIEENKRNDDSEADTAKLNAKEVATEEFNSDI 1973
+ E +ER + EE A +EE KRN E + ++ E+ I
Sbjct: 354 EERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKI 413
>gi|224586823 coiled-coil domain containing 110 isoform b [Homo
sapiens]
Length = 796
Score = 54.3 bits (129), Expect = 1e-06
Identities = 143/772 (18%), Positives = 295/772 (38%), Gaps = 130/772 (16%)
Query: 946 VYPEELKPVLTQAKQKFLLL-LPGLETVEMMEESSGPY--SDGTENSQLNVKISGMERKS 1002
+ P+ VL Q + F L + L+ V M E+ + + + + + + +E K
Sbjct: 50 IQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKL 109
Query: 1003 NGKRDSFLAQTKNKKENMKPAAKLKLESSSLKVKGEILLEEEKSTDFV-----------F 1051
+G + L Q+ N + L L +S+ + I++ +++D +
Sbjct: 110 SGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPT 169
Query: 1052 IPPEGKDAKERILTDHQK---EVLKTKRCD--------IPAMYNNLDVSQDTLFTQYSQE 1100
PP + ++ D K LK C+ I M L S D ++
Sbjct: 170 APPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNEL 229
Query: 1101 EPMEI-PTLTRKPK-------EDSKMMITEEQMDSDIVIPQDV-TEDCGMAEHLEKSSLS 1151
+ ++ P + R K +D I EE +D ++ +D+ ++ E L K L
Sbjct: 230 QTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNL--NEDIKSKRISELEALVKKLLP 287
Query: 1152 NNE------------CGSLDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSS 1199
E C L K+ N K+ I+ + + S + +S
Sbjct: 288 FRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSF 347
Query: 1200 SSVSNTTVAGTPPYPTSRRQTFITLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKT 1259
+ + RQ F+ + SEN S +N+++ K
Sbjct: 348 LDQTKHEMKD------KERQPFLVKQGSIISENE--KTSKVNSVTEQCVAK----IQYLQ 395
Query: 1260 DFLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVE 1319
++L ++ Q + + +SE + +K KPL+ + T+ ++
Sbjct: 396 NYLKESVQIQKKVMELESENLNLKSKM----------------KPLIFT-----TQSLIQ 434
Query: 1320 GIVVLENNPPGLLNQTECVSDNQVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVE 1379
+ E L+ + + E + E K + N + + T+EEKN++
Sbjct: 435 KVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQ 494
Query: 1380 INLESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTES----QDKE 1435
++LE ++ ++ + DQ+ +++ + Q + + + R S +E+ + QD++
Sbjct: 495 LSLEKQQ----MMEALDQLKSKEHKTQ--SDMAIVNNENNRMSIEMEAMKTNILLIQDEK 548
Query: 1436 NSHQKKERRKEEEK-----PLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTL 1490
+KK + +EK L++S L I + K+K +T QE L++ + +
Sbjct: 549 EMLEKKTHQLLKEKSSLGNELKESQLEI---IQLKEKERLAKTEQETLLQIIETVKD--- 602
Query: 1491 GETSANAETEQNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIE 1550
+K + E E + I+++ E + YQ+ A + L I+
Sbjct: 603 -------------EKLNLETTLQESTAARQIMEREIENI----QTYQS-TAEENFLQEIK 644
Query: 1551 NSESDSSEAK----EEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKA 1606
N++S++S K E G + K ++ I +E K QE IK EN
Sbjct: 645 NAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFEN---SISR 701
Query: 1607 TSEEDVSIKSPICEKQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSK 1658
+E+ + +++ + ++E +T+ + + + L + D +C + N+ SK
Sbjct: 702 LTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSD---KICNQHNDPSK 750
Score = 32.0 bits (71), Expect = 7.8
Identities = 47/232 (20%), Positives = 101/232 (43%), Gaps = 21/232 (9%)
Query: 1825 ESLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTV----GPCLGDSKNVSQESLETK 1880
E+ + N EE + S + + E + + FK + G +K + +++++
Sbjct: 437 ETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLS 496
Query: 1881 EEKPEETPKMEL--SLENVTVEGNACKVTESN-----LEKAKTMELNVGNEASFHGQERT 1933
EK + ++ S E+ T A E+N +E KT L + +E +++T
Sbjct: 497 LEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEML-EKKT 555
Query: 1934 KTGISEEAAIEENKRNDDSEADTAKLNAKE-VATEEFNSDISLSDNTTPVKLNAQTEISE 1992
+ E++++ + +S+ + +L KE +A E + + + + KLN +T + E
Sbjct: 556 HQLLKEKSSLGNELK--ESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQE 613
Query: 1993 QTAAGELDGG--NDVSDLHSSEETN----TKMKNNEEMMIGEAMAETGHDGE 2038
TAA ++ ++ S+ E N K +E + +++E G + E
Sbjct: 614 STAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECE 665
>gi|239753245 PREDICTED: similar to UPF0634 protein C [Homo sapiens]
Length = 710
Score = 53.9 bits (128), Expect = 2e-06
Identities = 94/502 (18%), Positives = 195/502 (38%), Gaps = 54/502 (10%)
Query: 1230 SENRPFSPSPLNNISSTVTVKNNQETMIKTDFLPKAKQREGTFSKSDSEKIVNGTKRSSR 1289
S+ +P S + + S + + ++ + KQ + + +D E V+ +
Sbjct: 162 SQKQPASKTASDKTDSALNTATEIKDGLQCGTVSSQKQ-QALKATTDEEGSVSNIATEIK 220
Query: 1290 RAGKAEQTGNKRSKPLMRSEPEKN-----TEESVEGIV--VLENNPPGLLNQTECVSDNQ 1342
K+ +++ L + EK+ T E +G + + + P L T D+
Sbjct: 221 DGEKSGTVSSQKKPALKATSDEKDSFSNITREKKDGEISRTVSSQKPPALKATSVKEDSV 280
Query: 1343 VHLSESTMEHDNTK---------LKAATVENAVLLETNTVEEKNVEINLESKENTPPVVI 1393
++++ + + ++ LKA E LL ++ + S P +
Sbjct: 281 LNIAREKKDGEKSRTVSFDQPPGLKATRDEKDSLLNIARGKKNGEKTRRVSSRKKPALKA 340
Query: 1394 SADQMVNEDSQVQITPNQKT---LRRSSRRRSEVVESTTESQD------KENSHQKKERR 1444
++D+ +DS IT +K R+ S ++ ++ T++ +D +EN +K R
Sbjct: 341 TSDE---KDSFSNITRGKKDGEISRKVSSQKPPTLKGTSDEEDSVLGIARENKDGEKSRT 397
Query: 1445 KEEEKPLQ-KSPLHIKDDVL--PKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQ 1501
EKP K+ KD VL + K E+T + + +K S E T E + + +
Sbjct: 398 VSSEKPPGLKASSDEKDSVLNIARGKKYGEKTKRVSSRKKPSL--EATSDEKDSFSNITR 455
Query: 1502 NKKKAD---------PENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENS 1552
KK + P +K D ++ + E ++R + GL ++ +
Sbjct: 456 EKKDGEISRKVSSQKPPALKGTSDEEDSVLGIARENKDGEKSRTVSSEKPPGLKATSDEK 515
Query: 1553 ES---------DSSEAKEEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSHD 1603
+S D + + SRKK + K + +SV +E+K ++ + +
Sbjct: 516 DSVLNIARGKKDGEKTRTVSSRKKPALKATSDEKDSVLYIAREKKDGEKSRTVSSQKQPA 575
Query: 1604 YKATSEEDVSIKSPICEKQDE--SNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAE 1661
KA +++ S+ + EK+DE S TV Q D + N+ E + +
Sbjct: 576 LKAICDKEDSVPNMATEKKDEQISGTVSSQKQPALKATSDKKDSVSNIPTEIKDGQQSGT 635
Query: 1662 YSFTSLPVPESNLRTRNAIKRL 1683
S P ++ ++++ +
Sbjct: 636 VSSQKQPAWKATSVKKDSVSNI 657
>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
Length = 282
Score = 53.5 bits (127), Expect = 2e-06
Identities = 54/228 (23%), Positives = 97/228 (42%), Gaps = 19/228 (8%)
Query: 1411 QKTLRRSSRRRSEVVESTTESQDKENSHQKKERRKEE--EKPLQKSPLHIKDDVLPKQKL 1468
Q+ RRS+R + +V T E + K S +K + K + E+ + S + + KQ+
Sbjct: 14 QEPKRRSARLSAMLVPVTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQAVAET---KQEA 70
Query: 1469 IAEQTLQENLIEKGSNLHEKTLGETSANAETEQN----------KKKADPENIKSEG-DG 1517
+ E+ EN + + E E E+N KK+A +K+E D
Sbjct: 71 VVEEDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQ 130
Query: 1518 TQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWKNKSN 1577
+D D++ EK G+ + G N + + ++ KE+G +K GK +
Sbjct: 131 KEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDG-KKGEDGKGNGEDG 189
Query: 1578 ESVDIQDQEEKVVKQECIKAENQSHDYKATSEE--DVSIKSPICEKQD 1623
+ ++EE+ K+ EN+ K +E DV +K E++D
Sbjct: 190 KEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKERED 237
Score = 51.2 bits (121), Expect = 1e-05
Identities = 51/236 (21%), Positives = 100/236 (42%), Gaps = 19/236 (8%)
Query: 1405 VQITPNQKTLRRSSRRR----SEVVESTTESQDKENSHQKKERRKEE---------EKPL 1451
V +TP K R SS R+ S+++E ++ + + K+E EE E +
Sbjct: 28 VPVTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKI 87
Query: 1452 QKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQNKKKADP--- 1508
++P K+ V K++ I + T + ++ K E E +QN++K +
Sbjct: 88 TEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKE 147
Query: 1509 -ENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKK 1567
++ K E DG +D +EK + + ++ G + + E E +EE ++
Sbjct: 148 DKDEKGEEDGKED--KNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKET 205
Query: 1568 RSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQD 1623
GK E D ++ ++ VK++ + E+ D EE K + E+++
Sbjct: 206 GDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEE 261
Score = 38.5 bits (88), Expect = 0.083
Identities = 47/236 (19%), Positives = 101/236 (42%), Gaps = 17/236 (7%)
Query: 1375 EKNVEINLES-KENTPPVVISADQMVN-EDSQVQITPNQKTLRRSSRRRSEVVESTTESQ 1432
E+N++ + ++ E V+ D N ++ + +IT + + + E +E TE
Sbjct: 53 EENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEKG 112
Query: 1433 DK-------ENSHQKKERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNL 1485
+ E +++++++++EE ++ K+D K + ++ N EKG +
Sbjct: 113 GEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGN--EKGEDA 170
Query: 1486 HEKTLGETSANAETEQNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGL 1545
EK G+ + + K E+ K E D + K +E G+ + +
Sbjct: 171 KEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENED---GKEKGDKKEGKDVK 227
Query: 1546 LSSIENSESDSSEAKEEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQS 1601
+ E D E +EG ++ +GK K E + ++++E + + + K E QS
Sbjct: 228 VKEDEKEREDGKE--DEGGNEEEAGKEKEDLKEEEEGKEEDE-IKEDDGKKEEPQS 280
Score = 35.4 bits (80), Expect = 0.70
Identities = 58/275 (21%), Positives = 101/275 (36%), Gaps = 36/275 (13%)
Query: 1878 ETKEEKPEETPKMELSLENVTVEGNACKVTESNLEKAKT--MELNVGNEASFHGQERTKT 1935
+ ++E + ++ L VT E + + S K K+ ME N+ A + + +
Sbjct: 11 DMRQEPKRRSARLSAMLVPVTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQAVAETKQEA 70
Query: 1936 GISEEAAIEENKRNDDSEADTAKLNAKEV----------ATEEFNSD-----ISLSDNTT 1980
+ E+ EN +N +++ A + KE+ ATE+ + +
Sbjct: 71 VVEED--YNENAKNGEAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEE 128
Query: 1981 PVKLNAQTEISEQTAAGELD----GGNDVSDLHSSEETNTKMKNNEEMMIGEAMAETGHD 2036
K + + + E+ AG+ D G D + + E K E+ GE G D
Sbjct: 129 DQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGED 188
Query: 2037 G--------ETENEGITTKTSKPDEAETNMLTAEMDNFVCDTVEMSTEEGIIDANKTETN 2088
G E E+ T + ++ + E + E E+G D E
Sbjct: 189 GKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNE-- 246
Query: 2089 TEYSKSEEKLDNNQMVMESDILQEDHHTSQKVEEP 2123
E K +E L + E D ++ED K EEP
Sbjct: 247 EEAGKEKEDLKEEEEGKEEDEIKED---DGKKEEP 278
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.346
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,935,289
Number of Sequences: 37866
Number of extensions: 4142041
Number of successful extensions: 19075
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 797
Number of HSP's that attempted gapping in prelim test: 14834
Number of HSP's gapped (non-prelim): 3732
length of query: 2472
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2353
effective length of database: 13,741,464
effective search space: 32333664792
effective search space used: 32333664792
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.