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Search of human proteins with 55956794
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55956794 neurotrophic tyrosine kinase, receptor, type 3
isoform c precursor [Homo sapiens]
(612 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55956794 neurotrophic tyrosine kinase, receptor, type 3 isofo... 1272 0.0
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo... 1096 0.0
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 1096 0.0
gi|65506779 neurotrophic tyrosine kinase, receptor, type 2 isofo... 366 e-101
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 366 e-101
gi|65506769 neurotrophic tyrosine kinase, receptor, type 2 isofo... 356 4e-98
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 355 5e-98
gi|55956790 neurotrophic tyrosine kinase, receptor, type 2 isofo... 280 4e-75
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 279 6e-75
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 278 1e-74
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 273 3e-73
gi|126517478 peroxidasin homolog-like [Homo sapiens] 92 1e-18
gi|109150416 peroxidasin [Homo sapiens] 84 5e-16
gi|118572606 hemicentin 1 [Homo sapiens] 82 1e-15
gi|51317373 netrin-G1 ligand [Homo sapiens] 76 8e-14
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 74 5e-13
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 74 5e-13
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 74 5e-13
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 72 1e-12
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 71 3e-12
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 71 3e-12
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 71 3e-12
gi|15147240 brother of CDO [Homo sapiens] 71 3e-12
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 69 1e-11
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 69 2e-11
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 69 2e-11
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 68 2e-11
gi|229089140 leucine rich repeat containing 24 [Homo sapiens] 68 3e-11
gi|41582239 immunoglobulin superfamily containing leucine-rich r... 67 4e-11
gi|5031809 immunoglobulin superfamily containing leucine-rich re... 67 4e-11
>gi|55956794 neurotrophic tyrosine kinase, receptor, type 3 isoform
c precursor [Homo sapiens]
Length = 612
Score = 1272 bits (3292), Expect = 0.0
Identities = 612/612 (100%), Positives = 612/612 (100%)
Query: 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ 60
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ
Sbjct: 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ 60
Query: 61 DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP 120
DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP
Sbjct: 61 DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP 120
Query: 121 RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA 180
RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
Sbjct: 121 RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA 180
Query: 181 KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD 240
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD
Sbjct: 181 KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD 240
Query: 241 VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT 300
VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT
Sbjct: 241 VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT 300
Query: 301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE 360
VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
Sbjct: 301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE 360
Query: 361 GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT 420
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT
Sbjct: 361 GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT 420
Query: 421 VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP 480
VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP
Sbjct: 421 VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP 480
Query: 481 LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTWVFSNIDNHGIL 540
LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTWVFSNIDNHGIL
Sbjct: 481 LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTWVFSNIDNHGIL 540
Query: 541 NLKDNRDHLVPSTHYIYEEPEVQSGEVSYPRSHGFREIMLNPISLPGHSKPLNHGIYVED 600
NLKDNRDHLVPSTHYIYEEPEVQSGEVSYPRSHGFREIMLNPISLPGHSKPLNHGIYVED
Sbjct: 541 NLKDNRDHLVPSTHYIYEEPEVQSGEVSYPRSHGFREIMLNPISLPGHSKPLNHGIYVED 600
Query: 601 VNVYFSKGRHGF 612
VNVYFSKGRHGF
Sbjct: 601 VNVYFSKGRHGF 612
>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform
a precursor [Homo sapiens]
Length = 839
Score = 1096 bits (2834), Expect = 0.0
Identities = 529/530 (99%), Positives = 530/530 (100%)
Query: 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ 60
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ
Sbjct: 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ 60
Query: 61 DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP 120
DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP
Sbjct: 61 DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP 120
Query: 121 RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA 180
RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
Sbjct: 121 RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA 180
Query: 181 KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD 240
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD
Sbjct: 181 KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD 240
Query: 241 VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT 300
VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT
Sbjct: 241 VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT 300
Query: 301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE 360
VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
Sbjct: 301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE 360
Query: 361 GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT 420
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT
Sbjct: 361 GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT 420
Query: 421 VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP 480
VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP
Sbjct: 421 VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP 480
Query: 481 LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTWV 530
LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDT+V
Sbjct: 481 LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYV 530
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
b precursor [Homo sapiens]
Length = 825
Score = 1096 bits (2834), Expect = 0.0
Identities = 529/530 (99%), Positives = 530/530 (100%)
Query: 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ 60
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ
Sbjct: 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ 60
Query: 61 DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP 120
DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP
Sbjct: 61 DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP 120
Query: 121 RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA 180
RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
Sbjct: 121 RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA 180
Query: 181 KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD 240
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD
Sbjct: 181 KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD 240
Query: 241 VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT 300
VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT
Sbjct: 241 VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT 300
Query: 301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE 360
VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
Sbjct: 301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE 360
Query: 361 GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT 420
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT
Sbjct: 361 GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT 420
Query: 421 VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP 480
VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP
Sbjct: 421 VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP 480
Query: 481 LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTWV 530
LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDT+V
Sbjct: 481 LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYV 530
>gi|65506779 neurotrophic tyrosine kinase, receptor, type 2 isoform
e precursor [Homo sapiens]
Length = 537
Score = 366 bits (940), Expect = e-101
Identities = 220/553 (39%), Positives = 308/553 (55%), Gaps = 63/553 (11%)
Query: 7 PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63
PA W G WL + + ACP +C CS + I C P G + FP LE
Sbjct: 10 PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
Query: 64 NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123
N D NIT I I N + L +N D+E Y GL+ LTI +SGL+ + +AF
Sbjct: 61 --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
Query: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183
KN +L++IN + N+LT+LS + F+ L L EL L N F CSCDI W++ QE ++ +
Sbjct: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
Query: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
+Q+LYC+N +PL + I C LP +++ NLTV EG + ++C+ +G P+P++ W
Sbjct: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
Query: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
V L S ++N T+ +L + N++S+D+G ++C+AEN+VG SV LTV++
Sbjct: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
Query: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355
P + LE P CI F V+GNP P L W +NG L ESK I H EY+
Sbjct: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
Query: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDN----FILFD 411
GCL + PTH NNG+YTLIAKN G + I+ HF+ P + N ++++
Sbjct: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
Query: 412 EVSPT--------------PPITVTHKPEEDTFGVSIAVGLAAFA-CVLLVVLFVMINKY 456
+ P VT K + V V +A+ LLV+LF++ K
Sbjct: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
Query: 457 GRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQY 516
R SKFGMKGP +VIS ++DSASPLHHI++G TPSS + GPD V+IGMT+IPVIENPQY
Sbjct: 457 ARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQY 516
Query: 517 FRQGHNCHKPDTW 529
F ++ KPDTW
Sbjct: 517 FGITNSQLKPDTW 529
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
c precursor [Homo sapiens]
Length = 822
Score = 366 bits (939), Expect = e-101
Identities = 223/564 (39%), Positives = 314/564 (55%), Gaps = 64/564 (11%)
Query: 7 PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63
PA W G WL + + ACP +C CS + I C P G + FP LE
Sbjct: 10 PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
Query: 64 NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123
N D NIT I I N + L +N D+E Y GL+ LTI +SGL+ + +AF
Sbjct: 61 --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
Query: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183
KN +L++IN + N+LT+LS + F+ L L EL L N F CSCDI W++ QE ++ +
Sbjct: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
Query: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
+Q+LYC+N +PL + I C LP +++ NLTV EG + ++C+ +G P+P++ W
Sbjct: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
Query: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
V L S ++N T+ +L + N++S+D+G ++C+AEN+VG SV LTV++
Sbjct: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
Query: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355
P + LE P CI F V+GNP P L W +NG L ESK I H EY+
Sbjct: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
Query: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDN----FILFD 411
GCL + PTH NNG+YTLIAKN G + I+ HF+ P + N ++++
Sbjct: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
Query: 412 EVSPT--------------PPITVTHKPEEDTFGVSIAVGLAAFA-CVLLVVLFVMINKY 456
+ P VT K + V V +A+ LLV+LF++ K
Sbjct: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
Query: 457 GRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQY 516
R SKFGMKGP +VIS ++DSASPLHHI++G TPSS + GPD V+IGMT+IPVIENPQY
Sbjct: 457 ARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQY 516
Query: 517 FRQGHNCHKPDTWVFSNIDNHGIL 540
F ++ KPDT+V +I H I+
Sbjct: 517 FGITNSQLKPDTFV-QHIKRHNIV 539
>gi|65506769 neurotrophic tyrosine kinase, receptor, type 2 isoform
d precursor [Homo sapiens]
Length = 553
Score = 356 bits (913), Expect = 4e-98
Identities = 220/569 (38%), Positives = 308/569 (54%), Gaps = 79/569 (13%)
Query: 7 PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63
PA W G WL + + ACP +C CS + I C P G + FP LE
Sbjct: 10 PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
Query: 64 NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123
N D NIT I I N + L +N D+E Y GL+ LTI +SGL+ + +AF
Sbjct: 61 --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
Query: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183
KN +L++IN + N+LT+LS + F+ L L EL L N F CSCDI W++ QE ++ +
Sbjct: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
Query: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
+Q+LYC+N +PL + I C LP +++ NLTV EG + ++C+ +G P+P++ W
Sbjct: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
Query: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
V L S ++N T+ +L + N++S+D+G ++C+AEN+VG SV LTV++
Sbjct: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
Query: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355
P + LE P CI F V+GNP P L W +NG L ESK I H EY+
Sbjct: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
Query: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDN----FILFD 411
GCL + PTH NNG+YTLIAKN G + I+ HF+ P + N ++++
Sbjct: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
Query: 412 EVSPT--------------PPITVTHKPEEDTFGVSIAVGLAAFA-CVLLVVLFVMINKY 456
+ P VT K + V V +A+ LLV+LF++ K
Sbjct: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
Query: 457 GRRSKFGMK----------------GPVAVISGEEDSASPLHHINHGITTPSSLDAGPDT 500
R SKFGMK GP +VIS ++DSASPLHHI++G TPSS + GPD
Sbjct: 457 ARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDA 516
Query: 501 VVIGMTRIPVIENPQYFRQGHNCHKPDTW 529
V+IGMT+IPVIENPQYF ++ KPDTW
Sbjct: 517 VIIGMTKIPVIENPQYFGITNSQLKPDTW 545
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
a precursor [Homo sapiens]
Length = 838
Score = 355 bits (912), Expect = 5e-98
Identities = 224/580 (38%), Positives = 314/580 (54%), Gaps = 80/580 (13%)
Query: 7 PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63
PA W G WL + + ACP +C CS + I C P G + FP LE
Sbjct: 10 PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
Query: 64 NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123
N D NIT I I N + L +N D+E Y GL+ LTI +SGL+ + +AF
Sbjct: 61 --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
Query: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183
KN +L++IN + N+LT+LS + F+ L L EL L N F CSCDI W++ QE ++ +
Sbjct: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
Query: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
+Q+LYC+N +PL + I C LP +++ NLTV EG + ++C+ +G P+P++ W
Sbjct: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
Query: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
V L S ++N T+ +L + N++S+D+G ++C+AEN+VG SV LTV++
Sbjct: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
Query: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355
P + LE P CI F V+GNP P L W +NG L ESK I H EY+
Sbjct: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
Query: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEP---------FPE---- 402
GCL + PTH NNG+YTLIAKN G + I+ HF+ P +P+
Sbjct: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
Query: 403 -----STDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAA-FACVLLVVLFVMINKY 456
+ D + + P VT K + V V +A+ LLV+LF++ K
Sbjct: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
Query: 457 GRRSKFGMK----------------GPVAVISGEEDSASPLHHINHGITTPSSLDAGPDT 500
R SKFGMK GP +VIS ++DSASPLHHI++G TPSS + GPD
Sbjct: 457 ARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDA 516
Query: 501 VVIGMTRIPVIENPQYFRQGHNCHKPDTWVFSNIDNHGIL 540
V+IGMT+IPVIENPQYF ++ KPDT+V +I H I+
Sbjct: 517 VIIGMTKIPVIENPQYFGITNSQLKPDTFV-QHIKRHNIV 555
>gi|55956790 neurotrophic tyrosine kinase, receptor, type 2 isoform
b precursor [Homo sapiens]
Length = 477
Score = 280 bits (715), Expect = 4e-75
Identities = 180/490 (36%), Positives = 257/490 (52%), Gaps = 63/490 (12%)
Query: 7 PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63
PA W G WL + + ACP +C CS + I C P G + FP LE
Sbjct: 10 PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
Query: 64 NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123
N D NIT I I N + L +N D+E Y GL+ LTI +SGL+ + +AF
Sbjct: 61 --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
Query: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183
KN +L++IN + N+LT+LS + F+ L L EL L N F CSCDI W++ QE ++ +
Sbjct: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
Query: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
+Q+LYC+N +PL + I C LP +++ NLTV EG + ++C+ +G P+P++ W
Sbjct: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
Query: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
V L S ++N T+ +L + N++S+D+G ++C+AEN+VG SV LTV++
Sbjct: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
Query: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355
P + LE P CI F V+GNP P L W +NG L ESK I H EY+
Sbjct: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
Query: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEP---------FPE---- 402
GCL + PTH NNG+YTLIAKN G + I+ HF+ P +P+
Sbjct: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
Query: 403 -----STDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAA-FACVLLVVLFVMINKY 456
+ D + + P VT K + V V +A+ LLV+LF++ K
Sbjct: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
Query: 457 GRRSKFGMKG 466
R SKFGMKG
Sbjct: 457 ARHSKFGMKG 466
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
1 [Homo sapiens]
Length = 790
Score = 279 bits (713), Expect = 6e-75
Identities = 172/444 (38%), Positives = 242/444 (54%), Gaps = 20/444 (4%)
Query: 77 SRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSS 136
+ N+T ++IEN + L L D+ L+ LTI SGLR + P AF P L +NLS
Sbjct: 65 AENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSF 124
Query: 137 NRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQ 196
N L +LSW+ Q LSL+EL L N +CSC +RW+Q W+E+G + Q L C Q
Sbjct: 125 NALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQC----HGQ 180
Query: 197 LPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQT 256
PL M + C +P + V N +V GD+ ++ C G L WI+T L+ T
Sbjct: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQ---SAT 237
Query: 257 NLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELR 316
+ + ++ LTL NVTS+ N +TC AEN VG + SV + V +P V E+
Sbjct: 238 VMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMH 297
Query: 317 LEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEG---EISEGCLLFNKPTHYNN 373
CI F V G P P+L WL NG L E+ I E+ + + GCL N+PTH NN
Sbjct: 298 -HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNN 356
Query: 374 GNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVS 433
GNYTL+A NP G A+ +I F+ PF + ++ I + P+ K +E FGVS
Sbjct: 357 GNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPV---EKKDETPFGVS 413
Query: 434 IAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSS 493
+AVGLA FAC+ L L +++NK GRR+KFG+ P AV++ E+ A LH + G ++ S
Sbjct: 414 VAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRP-AVLAPEDGLAMSLHFMTLGGSSLSP 472
Query: 494 LDAGPDTVVIGMTRIPVIENPQYF 517
+ G + + G +IENPQYF
Sbjct: 473 TE-GKGSGLQG----HIIENPQYF 491
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 278 bits (710), Expect = 1e-74
Identities = 175/458 (38%), Positives = 242/458 (52%), Gaps = 42/458 (9%)
Query: 77 SRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSS 136
+ N+T ++IEN + L L D+ L+ LTI SGLR + P AF P L +NLS
Sbjct: 65 AENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSF 124
Query: 137 NRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQ 196
N L +LSW+ Q LSL+EL L N +CSC +RW+Q W+E+G + Q L C Q
Sbjct: 125 NALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQC----HGQ 180
Query: 197 LPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQT 256
PL M + C +P + V N +V GD+ ++ C G L WI+T L+ T
Sbjct: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQ---SAT 237
Query: 257 NLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELR 316
+ + ++ LTL NVTS+ N +TC AEN VG + SV + V +P V E+
Sbjct: 238 VMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMH 297
Query: 317 LEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEG---EISEGCLLFNKPTHYNN 373
CI F V G P P+L WL NG L E+ I E+ + + GCL N+PTH NN
Sbjct: 298 -HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNN 356
Query: 374 GNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKP-------- 425
GNYTL+A NP G A+ +I F+ PF E +P PI V+ P
Sbjct: 357 GNYTLLAANPFGQASASIMAAFMDNPF-----------EFNPEDPIPVSFSPVDTNSTSG 405
Query: 426 ------EEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSAS 479
+E FGVS+AVGLA FAC+ L L +++NK GRR+KFG+ P AV++ E+ A
Sbjct: 406 DPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRP-AVLAPEDGLAM 464
Query: 480 PLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYF 517
LH + G ++ S + G + + G +IENPQYF
Sbjct: 465 SLHFMTLGGSSLSPTE-GKGSGLQG----HIIENPQYF 497
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
3 [Homo sapiens]
Length = 760
Score = 273 bits (698), Expect = 3e-73
Identities = 170/441 (38%), Positives = 239/441 (54%), Gaps = 20/441 (4%)
Query: 80 ITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRL 139
+ + +IEN + L L D+ L+ LTI SGLR + P AF P L +NLS N L
Sbjct: 38 LAASYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL 97
Query: 140 TTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPL 199
+LSW+ Q LSL+EL L N +CSC +RW+Q W+E+G + Q L C Q PL
Sbjct: 98 ESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQC----HGQGPL 153
Query: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLN 259
M + C +P + V N +V GD+ ++ C G L WI+T L+ T +
Sbjct: 154 AHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQ---SATVMK 210
Query: 260 WTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEH 319
+ ++ LTL NVTS+ N +TC AEN VG + SV + V +P V E+
Sbjct: 211 SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMH-HW 269
Query: 320 CIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEG---EISEGCLLFNKPTHYNNGNY 376
CI F V G P P+L WL NG L E+ I E+ + + GCL N+PTH NNGNY
Sbjct: 270 CIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNY 329
Query: 377 TLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAV 436
TL+A NP G A+ +I F+ PF + ++ I + P+ K +E FGVS+AV
Sbjct: 330 TLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPV---EKKDETPFGVSVAV 386
Query: 437 GLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDA 496
GLA FAC+ L L +++NK GRR+KFG+ P AV++ E+ A LH + G ++ S +
Sbjct: 387 GLAVFACLFLSTLLLVLNKCGRRNKFGINRP-AVLAPEDGLAMSLHFMTLGGSSLSPTE- 444
Query: 497 GPDTVVIGMTRIPVIENPQYF 517
G + + G +IENPQYF
Sbjct: 445 GKGSGLQG----HIIENPQYF 461
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 92.0 bits (227), Expect = 1e-18
Identities = 101/410 (24%), Positives = 163/410 (39%), Gaps = 66/410 (16%)
Query: 30 LACPANCVCSKTEINCR------------------------RPDDGNLFPLLEGQDSGNS 65
L CP+ C+C K+ + C R G+ F L+ ++
Sbjct: 22 LPCPSRCLCFKSTVRCMHLMLDHIPQVPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLL 81
Query: 66 NGNASINITDISRNITSIHIENWRSLHT----LNAVDMELYTGL---QKLTIKNSGLRSI 118
N N +I ISRN +EN L+ ++A+D + + GL + L I + L +
Sbjct: 82 NNN---HIRKISRNAFE-GLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEML 137
Query: 119 QPRAFAKNPHLRYINLSSNRLTTLSWQLFQTL-SLRELQLEQNFFNCSCDIRWM----QL 173
QP F L + L +N+L+ + F L SL+ L+L+ N C CD+ W+ Q
Sbjct: 138 QPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQG 197
Query: 174 WQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNG 233
+ + G + + Y G + + C P I+ ++ V G+ TC
Sbjct: 198 FAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRA 257
Query: 234 SGSPLPDVDWIVTGLQSINTHQTNL---NWTNVHAINLTLVNVTSEDNGFTLTCIAENVV 290
G+P P++ WI N H +L NV ++ T E + C+A N
Sbjct: 258 EGNPKPEIIWI------HNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSA 311
Query: 291 GMSNASVALTVY-----YPPRVVSLEEPELRL--EHCIEFVVRGNPPPTLHWLH-NGQPL 342
G + A+ Y P V+ ++ E+ + +E + G+P P + W NG L
Sbjct: 312 GEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLEL 371
Query: 343 RESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
S+ HV S G L N T ++G +T A N GT N
Sbjct: 372 DGSR--HV------ATSSGLYLQN-ITQRDHGRFTCHANNSHGTVQAAAN 412
Score = 55.1 bits (131), Expect = 2e-07
Identities = 46/186 (24%), Positives = 75/186 (40%), Gaps = 18/186 (9%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIV-TGLQSINTHQTNLNWTNVHAINL 268
P + + V G + + C +G P P + W GL+ + + L
Sbjct: 330 PSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHV------ATSSGL 383
Query: 269 TLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRL-EHCIEFVVR- 326
L N+T D+G TC A N G A+ + V PP+ + ++ L EH +E++
Sbjct: 384 YLQNITQRDHG-RFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEA 442
Query: 327 -GNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLG 385
GNPPP + W G L Q +S G L ++ ++ G Y A + LG
Sbjct: 443 DGNPPPVIVWTKTGGQLPVEG-------QHTVLSSGTLRIDRAAQHDQGQYECQAVSSLG 495
Query: 386 TANQTI 391
++
Sbjct: 496 VKKVSV 501
Score = 45.1 bits (105), Expect = 2e-04
Identities = 47/183 (25%), Positives = 68/183 (37%), Gaps = 17/183 (9%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
P+ +V+ + V E C G+P P + W TG Q Q T + + L
Sbjct: 419 PQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQ----HTVLSSGTLR 474
Query: 270 LVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEP-----ELRLEHCIEFV 324
+ D G C A + +G+ SV LTV V + P E+ I
Sbjct: 475 IDRAAQHDQG-QYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCH 533
Query: 325 VRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPL 384
+G P P + W G + ES HV+ EG L + G Y +A+N
Sbjct: 534 AQGEPQPIITWNKEGVQITESGKFHVD-------DEGTLTIYDAGFPDQGRYECVARNSF 586
Query: 385 GTA 387
G A
Sbjct: 587 GLA 589
Score = 34.7 bits (78), Expect = 0.26
Identities = 22/82 (26%), Positives = 39/82 (47%), Gaps = 5/82 (6%)
Query: 220 TVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNG 279
+V G N I+C+ G P P + W G+Q + + +++ LT+ + D G
Sbjct: 521 SVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG----TLTIYDAGFPDQG 576
Query: 280 FTLTCIAENVVGMSNASVALTV 301
C+A N G++ ++ LTV
Sbjct: 577 -RYECVARNSFGLAVTNMFLTV 597
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 83.6 bits (205), Expect = 5e-16
Identities = 83/399 (20%), Positives = 157/399 (39%), Gaps = 50/399 (12%)
Query: 32 CPANCVCSKTEINCRR----------PDDGNL---FPLLEGQDSGNSNGNASINITDISR 78
CP+ C+C +T + C P L F + G ++N ++
Sbjct: 36 CPSRCLCFRTTVRCMHLLLEAVPAVAPQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNN 95
Query: 79 N----ITSIHIENWRSL-------HTLNAVDMELYTGL---QKLTIKNSGLRSIQPRAFA 124
N I S E+ +L + + ++D + + GL ++L + + + ++ P +F
Sbjct: 96 NQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQ 155
Query: 125 KNPHLRYINLSSNRLTTLSWQLFQTL-SLRELQLEQNFFNCSCDIRWM----QLWQEQGE 179
P L + L +NR+T L F L S++ L+L+ N +C C+I W+ + + E G
Sbjct: 156 HLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGN 215
Query: 180 AKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLP 239
A+ + Y G + C+ P I+ + V G+ TC G+P P
Sbjct: 216 AQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKP 275
Query: 240 DVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVAL 299
++ W+ + + LN + + ++ T E + C+A+NV G
Sbjct: 276 EIIWLRNNNELSMKTDSRLNLLDDGTL---MIQNTQETDQGIYQCMAKNVAGEVKTQEVT 332
Query: 300 TVYY-----PPRVVSLEEPELRLEHCI--EFVVRGNPPPTLHWLHNGQ-PLRESKIIHVE 351
Y+ P V+ + E+ + + E G+PPP + W + PL +++
Sbjct: 333 LRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNI- 391
Query: 352 YYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQT 390
G L ++G Y A N + + + T
Sbjct: 392 ------TPSGGLYIQNVVQGDSGEYACSATNNIDSVHAT 424
Score = 51.2 bits (121), Expect = 3e-06
Identities = 49/188 (26%), Positives = 75/188 (39%), Gaps = 23/188 (12%)
Query: 209 LPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQ-SINTHQTNLNWTNVHAIN 267
LP+ +V+ + V EG C G+P P + W G Q S++ L+ +
Sbjct: 432 LPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLS-----SGT 486
Query: 268 LTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVV-------SLEEPELRLEHC 320
L + V D G C A N++G LTV PRV S E+
Sbjct: 487 LRISGVALHDQG-QYECQAVNIIGSQKVVAHLTV--QPRVTPVFASIPSDTTVEVGANVQ 543
Query: 321 IEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIA 380
+ +G P P + W +G + ES H+ EG L N + G Y +A
Sbjct: 544 LPCSSQGEPEPAITWNKDGVQVTESGKFHIS-------PEGFLTINDVGPADAGRYECVA 596
Query: 381 KNPLGTAN 388
+N +G+A+
Sbjct: 597 RNTIGSAS 604
Score = 44.3 bits (103), Expect = 3e-04
Identities = 32/126 (25%), Positives = 56/126 (44%), Gaps = 8/126 (6%)
Query: 182 LNSQNLY---CINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPL 238
L+ Q Y +N GSQ + + + P + + TV G N + C+ G P
Sbjct: 494 LHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPE 553
Query: 239 PDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVA 298
P + W G+Q + + +++ LT+ +V D G C+A N +G ++ S+
Sbjct: 554 PAITWNKDGVQVTESGKFHISPEGF----LTINDVGPADAG-RYECVARNTIGSASVSMV 608
Query: 299 LTVYYP 304
L+V P
Sbjct: 609 LSVNVP 614
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 82.0 bits (201), Expect = 1e-15
Identities = 70/230 (30%), Positives = 101/230 (43%), Gaps = 32/230 (13%)
Query: 179 EAKLNSQNLY-CI--NADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSG 235
E + + +Y C+ N G+ ++N+ P+I +L V+ G I CN G
Sbjct: 1139 ETRTSDSGMYLCVATNIAGNVTQAVKLNVHVP--PKIQRGPKHLKVQVGQRVDIPCNAQG 1196
Query: 236 SPLPDVDWIVTGLQSI---NTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGM 292
+PLP + W G + H +N + T L++ T D G TC+A N+ G
Sbjct: 1197 TPLPVITWSKGGSTMLVDGEHHVSNPDGT------LSIDQATPSDAGI-YTCVATNIAGT 1249
Query: 293 SNASVALTVYYPPRVVSLEEP------ELRLEHCIEF--VVRGNPPPTLHWLHNGQPL-- 342
+ L V PP V LE P E IEF +G P PT+ WLHNG+ L
Sbjct: 1250 DETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTG 1309
Query: 343 RESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
RE I +E +G + L+ T Y+NG Y +A N GT + N
Sbjct: 1310 REPGISILE---DGTL----LVIASVTPYDNGEYICVAVNEAGTTERKYN 1352
Score = 72.4 bits (176), Expect = 1e-12
Identities = 54/189 (28%), Positives = 88/189 (46%), Gaps = 19/189 (10%)
Query: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQ-SINTHQTNLNWTNVHAINLTLVNVTSE 276
N++V E ++ +TC SG PLP + W G S++ L+ + L L+ T E
Sbjct: 2395 NISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRM----LRLMQTTME 2450
Query: 277 DNGFTLTCIAENVVGMSNASVALTVYYPPRVV---SLEEPELRLEHCIEFV--VRGNPPP 331
D G TC+ N G L+V PP +V +LE+ +++ + + V GNP P
Sbjct: 2451 DAG-QYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVP 2509
Query: 332 TLHWLHNGQPLRESKIIHVEYYQEGEISEGCLL-FNKPTHYNNGNYTLIAKNPLGTANQT 390
+ W +GQPL+E + H+ IS G L + G YT +A +P G +++
Sbjct: 2510 EITWHKDGQPLQEDEAHHI-------ISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRS 2562
Query: 391 INGHFLKEP 399
+ + P
Sbjct: 2563 FSLNVFVSP 2571
Score = 70.1 bits (170), Expect = 6e-12
Identities = 66/243 (27%), Positives = 99/243 (40%), Gaps = 28/243 (11%)
Query: 191 NADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQS 250
N GS F +N+ I NLTV + +TC SG P PD+ W+
Sbjct: 2947 NTAGSAKKYFNLNV-HVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLK----- 3000
Query: 251 INTHQTNLNWTNVHAI----NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPR 306
N LN TN + L ++ D G TCIA N G S +LTVY PP
Sbjct: 3001 -NEQPIKLN-TNTLIVPGGRTLQIIRAKVSDGG-EYTCIAINQAGESKKKFSLTVYVPPS 3057
Query: 307 VVSLEEPELRLEH-------CIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEIS 359
+ + L + + +E PPP + W NG+ + ES HVE +G++
Sbjct: 3058 IKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITES--THVEILADGQM- 3114
Query: 360 EGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPI 419
L K + G Y A N G ++ + + P E + ++ + +S P+
Sbjct: 3115 ---LHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETIS--NPV 3169
Query: 420 TVT 422
T+T
Sbjct: 3170 TLT 3172
Score = 67.0 bits (162), Expect = 5e-11
Identities = 58/242 (23%), Positives = 107/242 (44%), Gaps = 23/242 (9%)
Query: 183 NSQNLYCI--NADGSQLPLFRMNISQCDLPEISVSHV--NLTVREGDNAVITCNGSGSPL 238
+S N CI N +G + ++I P ++ + + +++V G+N + CN +G P
Sbjct: 3218 DSGNYTCIASNMEGKAQKYYFLSIQVP--PSVAGAEIPSDVSVLLGENVELVCNANGIPT 3275
Query: 239 PDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVA 298
P + W+ G + I + +T + + L + + D G TC+A N G +
Sbjct: 3276 PLIQWLKDG-KPIASGETERIRVSANGSTLNIYGALTSDTG-KYTCVATNPAGEEDRIFN 3333
Query: 299 LTVYYPPRVVSLEEPELRLEHCIEFVVR------GNPPPTLHWLHNGQPLRESKIIHVEY 352
L VY P + ++ +L ++ + G PPP ++WL NG PL S H+
Sbjct: 3334 LNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSS--HIRL 3391
Query: 353 YQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDE 412
G++ + + + YT +A N G N+ N L+ P + DN + +E
Sbjct: 3392 LAAGQV----IRIVRAQVSDVAVYTCVASNRAGVDNKHYN---LQVFAPPNMDNSMGTEE 3444
Query: 413 VS 414
++
Sbjct: 3445 IT 3446
Score = 64.7 bits (156), Expect = 2e-10
Identities = 53/233 (22%), Positives = 96/233 (41%), Gaps = 28/233 (12%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
P I+ N+TV + C +G P P ++W G +N Q ++ + + +L
Sbjct: 3804 PSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNG-HLLNVDQNQNSYRLLSSGSLV 3862
Query: 270 LVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHC---IEFVVR 326
+++ + +D T C N G +V LTV PP + L +H I
Sbjct: 3863 IISPSVDDTA-TYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTAS 3921
Query: 327 GNPPPTLHWLHNGQPLRESKIIHVEYYQEGE----ISEGCLLFNKPTHYNNGNYTLIAKN 382
G P P++HW NG + G+ +S G + + G YT +A+N
Sbjct: 3922 GVPFPSIHWTKNG----------IRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARN 3971
Query: 383 PLGTANQTINGHFLKEPF--PESTDNFILFD-------EVSPTPPITVTHKPE 426
G+A++ + H + P P+ ++ ++ + E + TP +T + E
Sbjct: 3972 AAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKE 4024
Score = 63.9 bits (154), Expect = 4e-10
Identities = 49/179 (27%), Positives = 83/179 (46%), Gaps = 17/179 (9%)
Query: 213 SVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQ-SINTHQTNLNWTNVHAINLTLV 271
S+ +TV +G + + C G+P P + W+ G ++ H T + H + L L+
Sbjct: 3439 SMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLT----VSTHGMVLQLL 3494
Query: 272 NVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPE---LRLEHCIEF--VVR 326
+ED+G TCIA N G + L V PP + EE E + + + +E +
Sbjct: 3495 KAETEDSG-KYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIAS 3553
Query: 327 GNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLG 385
G P P + W+ +G+PL ++ V+ GE+ L + + G YT +A +P G
Sbjct: 3554 GIPAPKMTWMKDGRPLPQTD--QVQTLGGGEV----LRISTAQVEDTGRYTCLASSPAG 3606
Score = 62.4 bits (150), Expect = 1e-09
Identities = 63/212 (29%), Positives = 90/212 (42%), Gaps = 29/212 (13%)
Query: 213 SVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTG-LQSINTHQTNLNWTNVHAINLTLV 271
S+S VN VREG + + C + P P + W G + + +TH L + I V
Sbjct: 3065 SLSVVN--VREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEV 3122
Query: 272 NVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFV------- 324
+ T + C A NV G + + L VY PP S+E PE E +E +
Sbjct: 3123 SDTGQ-----YVCRAINVAGRDDKNFHLNVYVPP---SIEGPER--EVIVETISNPVTLT 3172
Query: 325 --VRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKN 382
G PPPT+ WL N + + S + V G L + H ++GNYT IA N
Sbjct: 3173 CDATGIPPPTIAWLKNHKRIENSDSLEVRILSGG----SKLQIARSQHSDSGNYTCIASN 3228
Query: 383 PLGTANQTINGHFLKEPFPESTDNFILFDEVS 414
G A + +FL P S + +VS
Sbjct: 3229 MEGKAQKY---YFLSIQVPPSVAGAEIPSDVS 3257
Score = 61.6 bits (148), Expect = 2e-09
Identities = 52/219 (23%), Positives = 90/219 (41%), Gaps = 17/219 (7%)
Query: 180 AKLNSQNLY---CINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGS 236
A+++ +Y IN+ G+ + + + P IS S+ + V + + C G
Sbjct: 1981 AQISDAGIYKCVAINSAGATELFYSLQVHVA--PSISGSNNMVAVVVNNPVRLECEARGI 2038
Query: 237 PLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNAS 296
P P + W+ G +++ L + I L L + D G TC+A N G
Sbjct: 2039 PAPSLTWLKDG-SPVSSFSNGLQVLSGGRI-LALTSAQISDTG-RYTCVAVNAAGEKQRD 2095
Query: 297 VALTVYYPPRVVSLEE-PELRLEHCIEFVVRGN--PPPTLHWLHNGQPLRESKIIHVEYY 353
+ L VY PP ++ E+ + + +E + + + PPPTL WL +G PL + + +
Sbjct: 2096 IDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISE- 2154
Query: 354 QEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
+ L + G YT A N G + N
Sbjct: 2155 -----NRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYN 2188
Score = 59.7 bits (143), Expect = 8e-09
Identities = 58/198 (29%), Positives = 84/198 (42%), Gaps = 26/198 (13%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNL--NWTNVHAIN 267
P I + + TV E A++ C G P P ++W + N NL +T
Sbjct: 4169 PRIRSTEGHYTVNENSQAILPCVADGIPTPAINW-----KKDNVLLANLLGKYTAEPYGE 4223
Query: 268 LTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRV------VSLEEPELRLEHCI 321
L L NV ED+GF TC+A N G +V+LTV+ P VSL + E C
Sbjct: 4224 LILENVVLEDSGF-YTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSC- 4281
Query: 322 EFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAK 381
G P P L W N + II + SE L+ + + ++G Y A+
Sbjct: 4282 --KATGIPLPKLTWTFN------NNIIPAHFDSVNGHSE--LVIERVSKEDSGTYVCTAE 4331
Query: 382 NPLGTANQTINGHFLKEP 399
N +G + I ++KEP
Sbjct: 4332 NSVGFV-KAIGFVYVKEP 4348
Score = 59.7 bits (143), Expect = 8e-09
Identities = 48/189 (25%), Positives = 83/189 (43%), Gaps = 19/189 (10%)
Query: 209 LPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINL 268
LP + ++++ +G+ ++C +G PLP + W N + + N H+ L
Sbjct: 4259 LPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNN----NIIPAHFDSVNGHS-EL 4313
Query: 269 TLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLE-----HCIEF 323
+ V+ ED+G T C AEN VG A + V PP V + P +E +
Sbjct: 4314 VIERVSKEDSG-TYVCTAENSVGFVKAIGFVYVKEPP-VFKGDYPSNWIEPLGGNAILNC 4371
Query: 324 VVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNP 383
V+G+P PT+ W G + S I ++ G L + + G+YT +A N
Sbjct: 4372 EVKGDPTPTIQWNRKGVDIEISHRIR-------QLGNGSLAIYGTVNEDAGDYTCVATNE 4424
Query: 384 LGTANQTIN 392
G ++++
Sbjct: 4425 AGVVERSMS 4433
Score = 59.3 bits (142), Expect = 1e-08
Identities = 43/178 (24%), Positives = 77/178 (43%), Gaps = 16/178 (8%)
Query: 219 LTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDN 278
LTV EG+ + C SG P P++ W G + + + +++ + +
Sbjct: 2206 LTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILS--GGRQLQISIAEKSD 2263
Query: 279 GFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRL------EHCIEFVVRGNPPPT 332
+C+A NV G + L VY P + + + +E V+G PPPT
Sbjct: 2264 AALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPT 2323
Query: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNN-GNYTLIAKNPLGTANQ 389
+ W+ +G PL ++K + + + EG +L K H ++ G Y +A N G ++
Sbjct: 2324 VTWMKDGHPLIKAKGVEI-------LDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDK 2374
Score = 57.8 bits (138), Expect = 3e-08
Identities = 45/182 (24%), Positives = 74/182 (40%), Gaps = 15/182 (8%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
P I+ + V + AVITC SG P P + W G++ + + + +
Sbjct: 3897 PSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLL----PRGDGYRILSSGAI 3952
Query: 270 LVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRL----EHCIEFVV 325
+ T ++ TC+A N G ++ V L V+ PP V+ + EL + +
Sbjct: 3953 EILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPP-VIQPQPSELHVILNNPILLPCEA 4011
Query: 326 RGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLG 385
G P P + W G + S H + G L ++ + G Y +A+NP G
Sbjct: 4012 TGTPSPFITWQKEGINVNTSGRNH------AVLPSGGLQISRAVREDAGTYMCVAQNPAG 4065
Query: 386 TA 387
TA
Sbjct: 4066 TA 4067
Score = 57.0 bits (136), Expect = 5e-08
Identities = 53/206 (25%), Positives = 89/206 (43%), Gaps = 18/206 (8%)
Query: 191 NADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAV-ITCNGSGSPLPDVDWIVTGLQ 249
N G+ L ++N+ +P + H+ V D + ++C G P PD+ W G
Sbjct: 4062 NPAGTALGKIKLNVQ---VPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRA 4118
Query: 250 SINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVS 309
+ + + + + + +L + V D G TC+A NV G S+ S LTV+ PPR+ S
Sbjct: 4119 IVESIRQRV----LSSGSLQIAFVQPGDAGH-YTCMAANVAGSSSTSTKLTVHVPPRIRS 4173
Query: 310 LEEPELRLEH---CIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFN 366
E E+ + V G P P ++W + L + +Y E G L+
Sbjct: 4174 TEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLAN---LLGKYTAE---PYGELILE 4227
Query: 367 KPTHYNNGNYTLIAKNPLGTANQTIN 392
++G YT +A N G T++
Sbjct: 4228 NVVLEDSGFYTCVANNAAGEDTHTVS 4253
Score = 56.2 bits (134), Expect = 8e-08
Identities = 45/141 (31%), Positives = 63/141 (44%), Gaps = 16/141 (11%)
Query: 208 DLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSI-NTHQTNLNWTNVHAI 266
DLPE +TV +A+I C SGSP P W G + + H L+ +
Sbjct: 2877 DLPE------EVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRI--- 2927
Query: 267 NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELR--LEHCIEFV 324
L ++N D G C+AEN G + L V+ PP V+ + L + + I
Sbjct: 2928 -LQILNTQITDIG-RYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLT 2985
Query: 325 --VRGNPPPTLHWLHNGQPLR 343
V G PPP L WL N QP++
Sbjct: 2986 CEVSGFPPPDLSWLKNEQPIK 3006
Score = 55.5 bits (132), Expect = 1e-07
Identities = 48/180 (26%), Positives = 73/180 (40%), Gaps = 19/180 (10%)
Query: 213 SVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTN-LNWTNVHAINLTLV 271
S H ++V + +TC SG P P + W+ G T Q L V I+ V
Sbjct: 3532 SEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQV 3591
Query: 272 NVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPE-----LRLEHCIEFVVR 326
ED G TC+A + G + + V+ PP + +EP + +E
Sbjct: 3592 ----EDTG-RYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSD 3646
Query: 327 GNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEG-CLLFNKPTHYNNGNYTLIAKNPLG 385
PPP + WL NG+ L+ + + + +S G L N + NYT +A N G
Sbjct: 3647 AVPPPVITWLRNGERLQATPRVRI-------LSGGRYLQINNADLGDTANYTCVASNIAG 3699
Score = 54.7 bits (130), Expect = 2e-07
Identities = 39/167 (23%), Positives = 72/167 (43%), Gaps = 17/167 (10%)
Query: 224 GDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLT 283
G NA++ C G P P + W G+ +H+ + +L + +ED G T
Sbjct: 4364 GGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIR----QLGNGSLAIYGTVNEDAG-DYT 4418
Query: 284 CIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPTLHWLHNG 339
C+A N G+ S++LT+ PP +++LE E + + ++ G P PT+ W G
Sbjct: 4419 CVATNEAGVVERSMSLTLQSPP-IITLEPVETVINAGGKIILNCQATGEPQPTITWSRQG 4477
Query: 340 QPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGT 386
+ ++V +S L + + +A+N +G+
Sbjct: 4478 HSISWDDRVNV-------LSNNSLYIADAQKEDTSEFECVARNLMGS 4517
Score = 54.3 bits (129), Expect = 3e-07
Identities = 47/174 (27%), Positives = 76/174 (43%), Gaps = 21/174 (12%)
Query: 229 ITCNGSGSPLPDVDWIVTGLQ-SINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAE 287
I C +G+P P ++W+ GL +++H L V I V+ + TC+A
Sbjct: 3362 IECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVA-----VYTCVAS 3416
Query: 288 NVVGMSNASVALTVYYPPRVV-SLEEPELRL----EHCIEFVVRGNPPPTLHWLHNGQPL 342
N G+ N L V+ PP + S+ E+ + + + G P P++ WL +GQPL
Sbjct: 3417 NRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPL 3476
Query: 343 RESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFL 396
H+ G + L K ++G YT IA N G ++ HF+
Sbjct: 3477 --GLDAHLTVSTHGMV----LQLLKAETEDSGKYTCIASNEAG----EVSKHFI 3520
Score = 53.9 bits (128), Expect = 4e-07
Identities = 54/209 (25%), Positives = 91/209 (43%), Gaps = 20/209 (9%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
P+ S HV L + ++ C +G+P P + W G IN + + N + + L
Sbjct: 3992 PQPSELHVILN----NPILLPCEATGTPSPFITWQKEG---INVNTSGRNHAVLPSGGLQ 4044
Query: 270 LVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVS--LEEPELRLEHCIEFVVR- 326
+ ED G T C+A+N G + + L V PP V+S L+E + ++ I
Sbjct: 4045 ISRAVREDAG-TYMCVAQNPAGTALGKIKLNVQVPP-VISPHLKEYVIAVDKPITLSCEA 4102
Query: 327 -GNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLG 385
G PPP + W +G+ + VE ++ +S G L + G+YT +A N G
Sbjct: 4103 DGLPPPDITWHKDGRAI-------VESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAG 4155
Query: 386 TANQTINGHFLKEPFPESTDNFILFDEVS 414
+++ + P ST+ +E S
Sbjct: 4156 SSSTSTKLTVHVPPRIRSTEGHYTVNENS 4184
Score = 52.4 bits (124), Expect = 1e-06
Identities = 38/134 (28%), Positives = 61/134 (45%), Gaps = 11/134 (8%)
Query: 214 VSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNV 273
V++V++ + + N + C G+P P + W +Q T + + N I L L
Sbjct: 1367 VTNVSVLLNQLTN--LFCEVEGTPSPIIMWYKDNVQV--TESSTIQTVNNGKI-LKLFRA 1421
Query: 274 TSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPE-----LRLEHCIEFVVRGN 328
T ED G +C A N+ G S + V PP ++ P L + +E V+G
Sbjct: 1422 TPEDAG-RYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGT 1480
Query: 329 PPPTLHWLHNGQPL 342
P P +HW +G+PL
Sbjct: 1481 PFPDIHWFKDGKPL 1494
Score = 52.0 bits (123), Expect = 2e-06
Identities = 43/186 (23%), Positives = 74/186 (39%), Gaps = 16/186 (8%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
P+++V N + G I C+ +G P P + W V + + +H+ + L
Sbjct: 612 PKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDG----TLF 667
Query: 270 LVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLE----HCIEFVV 325
+ N +D G C+A N G + L P+++ ++ EL + +E
Sbjct: 668 IKNAAPKDAGI-YGCLASNSAGTDKQNSTLRYIEAPKLMVVQS-ELLVALGDITVMECKT 725
Query: 326 RGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLG 385
G PPP + W LR S + ++ G L + + G+YT +A N G
Sbjct: 726 SGIPPPQVKWFKGDLELRPSTFLIIDPLL------GLLKIQETQDLDAGDYTCVAINEAG 779
Query: 386 TANQTI 391
A I
Sbjct: 780 RATGKI 785
Score = 51.6 bits (122), Expect = 2e-06
Identities = 45/184 (24%), Positives = 77/184 (41%), Gaps = 23/184 (12%)
Query: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAIN---LTLVNVT 274
++++ G N + C G P P + W L ++ + +++ + L ++N+
Sbjct: 801 DVSMEIGSNVTLPCYVQGYPEPTIKW--RRLDNMPIFSRPFSVSSISQLRTGALFILNLW 858
Query: 275 SEDNGFTLTCIAENVVGMSNASVALTVY--------YPPRVVSLEEPELRLEHCIEFVVR 326
+ D G T C AEN G + +TV P V ++ E + C ++
Sbjct: 859 ASDKG-TYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCT--LLA 915
Query: 327 GNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGT 386
GNP P W+ N L ++ I V S+G L + + G YT +A N GT
Sbjct: 916 GNPIPERRWIKNSAMLLQNPYITVR-------SDGSLHIERVQLQDGGEYTCVASNVAGT 968
Query: 387 ANQT 390
N+T
Sbjct: 969 NNKT 972
Score = 51.6 bits (122), Expect = 2e-06
Identities = 50/194 (25%), Positives = 85/194 (43%), Gaps = 21/194 (10%)
Query: 209 LPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINL 268
LP I L+ EG + C SG+P P V W G + I+T ++ ++ +L
Sbjct: 980 LPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKG-ELIST--SSAKFSAGADGSL 1036
Query: 269 TLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRV------VSLEEP-ELRL---- 317
+V+ E++G C A N G + V LTVY PRV +S ++P E+ +
Sbjct: 1037 YVVSPGGEESG-EYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGE 1095
Query: 318 EHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYT 377
E + V+ PPP + W +E+++I + + G + + ++G Y
Sbjct: 1096 EVTLPCEVKSLPPPIITW------AKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYL 1149
Query: 378 LIAKNPLGTANQTI 391
+A N G Q +
Sbjct: 1150 CVATNIAGNVTQAV 1163
Score = 50.1 bits (118), Expect = 6e-06
Identities = 46/181 (25%), Positives = 78/181 (43%), Gaps = 19/181 (10%)
Query: 213 SVSH-VNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLV 271
S SH + V G + + C G P P V W+ G I + H + L +
Sbjct: 2295 SGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEI-LDEGHILQLKNI 2353
Query: 272 NVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVV----SLEEPELRLEHCIEFV--V 325
+V+ D G C+A NV GM++ L+V+ PP ++ S E + ++ +
Sbjct: 2354 HVS--DTG-RYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEA 2410
Query: 326 RGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLL-FNKPTHYNNGNYTLIAKNPL 384
G P P++ W +G P+ S + + +S G +L + T + G YT + +N
Sbjct: 2411 SGIPLPSITWFKDGWPVSLSNSVRI-------LSGGRMLRLMQTTMEDAGQYTCVVRNAA 2463
Query: 385 G 385
G
Sbjct: 2464 G 2464
Score = 48.9 bits (115), Expect = 1e-05
Identities = 41/150 (27%), Positives = 66/150 (44%), Gaps = 12/150 (8%)
Query: 210 PEISVSHVNLTVREGDNAVIT--CNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAIN 267
P I +V + N++I C G P+P + W G Q I + L ++
Sbjct: 1546 PSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDG-QPIMSSSQALYIDKGQYLH 1604
Query: 268 LTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVV-SLEEP---ELRLEHCI-- 321
+ V+ + T TC NV G + S + VY PP + +L P ++ + H +
Sbjct: 1605 IPRAQVS---DSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTL 1661
Query: 322 EFVVRGNPPPTLHWLHNGQPLRESKIIHVE 351
E GNP P L WL +G P++ + I +E
Sbjct: 1662 ECKAAGNPSPILTWLKDGVPVKANDNIRIE 1691
Score = 48.5 bits (114), Expect = 2e-05
Identities = 43/176 (24%), Positives = 66/176 (37%), Gaps = 22/176 (12%)
Query: 226 NAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAIN----LTLVNVTSEDNGFT 281
+ + C G+P PD+ W G L NV ++ L L N D G
Sbjct: 1470 DVALECQVKGTPFPDIHWFKDGKPLF------LGDPNVELLDRGQVLHLKNARRNDKG-R 1522
Query: 282 LTCIAENVVGMSNASVALTVYYPPRVVS---LEEPELRLEHCI--EFVVRGNPPPTLHWL 336
C N G + LT+Y PP + + + + I E RG P P + W
Sbjct: 1523 YQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWY 1582
Query: 337 HNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
+GQP+ S Y +G+ L + ++ YT N GTA ++ +
Sbjct: 1583 KDGQPIMSSS--QALYIDKGQY----LHIPRAQVSDSATYTCHVANVAGTAEKSFH 1632
Score = 48.1 bits (113), Expect = 2e-05
Identities = 37/152 (24%), Positives = 63/152 (41%), Gaps = 11/152 (7%)
Query: 189 CINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGL 248
C+ ++ + + + P++ V L V GD V+ C SG P P V W L
Sbjct: 681 CLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDL 740
Query: 249 QSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVV 308
+ + ++ + L + T + + TC+A N G + + L V PP V
Sbjct: 741 ELRPSTFLIID----PLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPP--V 794
Query: 309 SLEEP-----ELRLEHCIEFVVRGNPPPTLHW 335
++EP E+ + V+G P PT+ W
Sbjct: 795 FIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW 826
Score = 48.1 bits (113), Expect = 2e-05
Identities = 45/183 (24%), Positives = 74/183 (40%), Gaps = 32/183 (17%)
Query: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTG--LQSINTHQTNLNWTNVHAIN----LTLV 271
++ V+E + +TC +G+P+P++ W G LQ H H I+ L +
Sbjct: 2488 DVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAH---------HIISGGRFLQIT 2538
Query: 272 NVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSL------EEPELRLEHCIEFVV 325
NV G TC+A + G + S +L V+ P + + E+ + L V
Sbjct: 2539 NVQVPHTG-RYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVC 2597
Query: 326 RGN--PPPTLHWLHNGQPLRESKIIHVEYYQEGEISEG-CLLFNKPTHYNNGNYTLIAKN 382
PP T+ W +G PL ++ I + + G L N G Y+ +A N
Sbjct: 2598 EAYSYPPATITWFKDGTPLESNRNIRI-------LPGGRTLQILNAQEDNAGRYSCVATN 2650
Query: 383 PLG 385
G
Sbjct: 2651 EAG 2653
Score = 47.4 bits (111), Expect = 4e-05
Identities = 43/184 (23%), Positives = 74/184 (40%), Gaps = 13/184 (7%)
Query: 229 ITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAEN 288
+ C+ +GSP P + W+ G Q I+ N + + V+ N C+A N
Sbjct: 1754 LDCHVTGSPPPTIMWLKDG-QLIDERDGFKILLNGRKLVIAQAQVS---NTGLYRCMAAN 1809
Query: 289 VVGMSNASVALTVYYPPRVVSLEEPELRLEH----CIEFVVRGNPPPTLHWLHNGQPLRE 344
G +TV+ PP + S E + ++ + G P P++ WL + QP+
Sbjct: 1810 TAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNT 1869
Query: 345 SKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPEST 404
++ +++ G + L K + G YT +A N G Q I H + P E
Sbjct: 1870 AQ-GNLKIQSSGRV----LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDA 1924
Query: 405 DNFI 408
+
Sbjct: 1925 GKML 1928
Score = 45.8 bits (107), Expect = 1e-04
Identities = 36/125 (28%), Positives = 53/125 (42%), Gaps = 14/125 (11%)
Query: 229 ITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAEN 288
+ C +G P P + W+ Q +NT Q NL + + L + ED G TC+A N
Sbjct: 1846 LQCIANGIPNPSITWLKDD-QPVNTAQGNLKIQSSGRV-LQIAKTLLEDAG-RYTCVATN 1902
Query: 289 VVGMSNASVALTVYYPPRVVSLEEPELRLEHCI--------EFVVRGNPPPTLHWLHNGQ 340
G + + L V+ PP SLE+ L + E GNP P + W + +
Sbjct: 1903 AAGETQQHIQLHVHEPP---SLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNR 1959
Query: 341 PLRES 345
L S
Sbjct: 1960 LLSGS 1964
Score = 45.8 bits (107), Expect = 1e-04
Identities = 46/196 (23%), Positives = 74/196 (37%), Gaps = 25/196 (12%)
Query: 203 NISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTN 262
NI+ D P ++TV + C P P + W+ G + T + +
Sbjct: 3621 NIAGTDEPR------DITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGG 3674
Query: 263 VHAINLTLVNVTSEDNGFTL--TCIAENVVGMSNASVALTVYYPPRVVSLEEP---ELRL 317
+ + + + D G T TC+A N+ G + LTV PP + + L
Sbjct: 3675 RY------LQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNK 3728
Query: 318 EHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHY-NNGNY 376
+E + G P P + W +G L + H Y I E L + H + G Y
Sbjct: 3729 STVLECIAEGVPTPRITWRKDGAVLAGN---HARY----SILENGFLHIQSAHVTDTGRY 3781
Query: 377 TLIAKNPLGTANQTIN 392
+A N GT + I+
Sbjct: 3782 LCMATNAAGTDRRRID 3797
Score = 45.4 bits (106), Expect = 1e-04
Identities = 52/211 (24%), Positives = 86/211 (40%), Gaps = 24/211 (11%)
Query: 191 NADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTG-LQ 249
NA G ++++ + E + +N TV + + C +G+P+P + W L
Sbjct: 1902 NAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLL 1961
Query: 250 SINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRV-- 307
S +T T LN + + + + D G C+A N G + +L V+ P +
Sbjct: 1962 SGSTSMTFLNRGQI----IDIESAQISDAGI-YKCVAINSAGATELFYSLQVHVAPSISG 2016
Query: 308 ------VSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEG 361
V + P +RL E RG P P+L WL +G P+ S ++ G I
Sbjct: 2017 SNNMVAVVVNNP-VRL----ECEARGIPAPSLTWLKDGSPV-SSFSNGLQVLSGGRI--- 2067
Query: 362 CLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
L + G YT +A N G + I+
Sbjct: 2068 -LALTSAQISDTGRYTCVAVNAAGEKQRDID 2097
Score = 44.7 bits (104), Expect = 3e-04
Identities = 43/174 (24%), Positives = 71/174 (40%), Gaps = 14/174 (8%)
Query: 231 CNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVV 290
C G+P P + W+ G + + + ++ + L + +VT DNG + C+A N
Sbjct: 1288 CPAKGTPKPTIKWLHNG-RELTGREPGISILEDGTL-LVIASVTPYDNGEYI-CVAVNEA 1344
Query: 291 GMSNASVALTVYYPPRVVSLEE---PELRLEHCIEFV--VRGNPPPTLHWLHNGQPLRES 345
G + L V+ PP + E+ + L V G P P + W + + ES
Sbjct: 1345 GTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTES 1404
Query: 346 KIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEP 399
I + G+I L + T + G Y+ A N GT+ + N L P
Sbjct: 1405 STI--QTVNNGKI----LKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPP 1452
Score = 43.5 bits (101), Expect = 6e-04
Identities = 55/205 (26%), Positives = 85/205 (41%), Gaps = 27/205 (13%)
Query: 231 CNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVV 290
C + +P P + W G + + L + + V ED G TC+A N
Sbjct: 2799 CETNAAPPPTLTWYKDG-HPLTSSDKVLILPGGRVLQIPRAKV--EDAG-RYTCVAVNEA 2854
Query: 291 GMSNASVALTVYYPPRV--VSLEEPE-----LRLEHCIEFVVRGNPPPTLHWLHNGQPLR 343
G + + V PP + + + PE + IE + G+P P W +GQPL
Sbjct: 2855 GEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLL 2914
Query: 344 ESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPF--- 400
E H ++ G I + +L + T + G Y +A+N G+A + N + P
Sbjct: 2915 EDD--HHKFLSNGRILQ--ILNTQIT--DIGRYVCVAENTAGSAKKYFNLNVHVPPSVIG 2968
Query: 401 PES------TDNFI-LFDEVSPTPP 418
P+S +NFI L EVS PP
Sbjct: 2969 PKSENLTVVVNNFISLTCEVSGFPP 2993
Score = 43.1 bits (100), Expect = 7e-04
Identities = 41/188 (21%), Positives = 73/188 (38%), Gaps = 15/188 (7%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
P I +L + + V+ C G P P + W G H N +++
Sbjct: 3713 PNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGF-LHIQ 3771
Query: 270 LVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVV---SLEEPELRLEHCIEFVVR 326
+VT D G L C+A N G + L V+ PP + + + ++ +
Sbjct: 3772 SAHVT--DTGRYL-CMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEAT 3828
Query: 327 GNPPPTLHWLHNGQPLRESKIIHVEYYQEGE--ISEGCLLFNKPTHYNNGNYTLIAKNPL 384
G P P+++W NG +++V+ Q +S G L+ P+ + Y N
Sbjct: 3829 GIPKPSINWRKNGH------LLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGA 3882
Query: 385 GTANQTIN 392
G +T++
Sbjct: 3883 GDDKRTVD 3890
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/133 (23%), Positives = 57/133 (42%), Gaps = 9/133 (6%)
Query: 217 VNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSE 276
+N V + + C +G+P P + W+ G+ + L +++
Sbjct: 1649 LNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIE---AGGKKLEIMSAQEI 1705
Query: 277 DNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPE---LRLEHCIEFV--VRGNPPP 331
D G + C+A +V G + V PP + +E + + + +E V G+PPP
Sbjct: 1706 DRGQYI-CVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPP 1764
Query: 332 TLHWLHNGQPLRE 344
T+ WL +GQ + E
Sbjct: 1765 TIMWLKDGQLIDE 1777
Score = 42.0 bits (97), Expect = 0.002
Identities = 52/197 (26%), Positives = 80/197 (40%), Gaps = 22/197 (11%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNL----NWTNVHA 265
P I V + N+TV G+ AV+TC + VD+ +T + N L +
Sbjct: 521 PVIQVPN-NVTVTPGERAVLTC----LIISAVDYNLTWQR--NDRDVRLAEPARIRTLAN 573
Query: 266 INLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPEL---RLEHCIE 322
++L L +V D G C+ + G S ASV LTV PP+V + + + E I
Sbjct: 574 LSLELKSVKFNDAG-EYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIM 632
Query: 323 FVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKN 382
G P P + W N + V ++ S+G L + G Y +A N
Sbjct: 633 CSATGYPKPKIAWTVN-------DMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASN 685
Query: 383 PLGTANQTINGHFLKEP 399
GT Q +++ P
Sbjct: 686 SAGTDKQNSTLRYIEAP 702
Score = 41.2 bits (95), Expect = 0.003
Identities = 42/188 (22%), Positives = 74/188 (39%), Gaps = 13/188 (6%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
P I N++V + C P P + W+ G + + L+ + ++ L
Sbjct: 2104 PNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLK--KPGLSISENRSV-LK 2160
Query: 270 LVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEE-PELRL--EHCIEFVVR 326
+ + +D G TC A NV G + + + ++ PP + +E +L + + I +
Sbjct: 2161 IEDAQVQDTG-RYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCE 2219
Query: 327 --GNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPL 384
G PPP L W G P+ + V G L + + Y+ +A N
Sbjct: 2220 SSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGR----QLQISIAEKSDAALYSCVASNVA 2275
Query: 385 GTANQTIN 392
GTA + N
Sbjct: 2276 GTAKKEYN 2283
Score = 41.2 bits (95), Expect = 0.003
Identities = 42/197 (21%), Positives = 72/197 (36%), Gaps = 25/197 (12%)
Query: 204 ISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNV 263
I++ DL +S + ++ + + C P + W G + N+ N
Sbjct: 2669 INKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIA-ANG 2727
Query: 264 HAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSL------------- 310
H + + ++ D G TC+A N+ G + + PP L
Sbjct: 2728 HTLQIKEAQIS--DTG-RYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNG 2784
Query: 311 EEPELRLEHCIEFVVRGN--PPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKP 368
E ++ + + I N PPPTL W +G PL S + + G + L +
Sbjct: 2785 EAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLI--LPGGRV----LQIPRA 2838
Query: 369 THYNNGNYTLIAKNPLG 385
+ G YT +A N G
Sbjct: 2839 KVEDAGRYTCVAVNEAG 2855
Score = 37.7 bits (86), Expect = 0.031
Identities = 39/179 (21%), Positives = 65/179 (36%), Gaps = 21/179 (11%)
Query: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277
++TV + C P + W G ++N N + + ED
Sbjct: 2584 DVTVILNSPTSLVCEAYSYPPATITWFKDGTPL----ESNRNIRILPGGRTLQILNAQED 2639
Query: 278 NGFTLTCIAENVVGMSNASVALTVYYPPRV---------VSLEEPELRLEH--CIEFVVR 326
N +C+A N G + VY PP + +S +E ++++ + +E
Sbjct: 2640 NAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAY 2699
Query: 327 GNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLG 385
P +L W +GQPL+ HV G L + + G YT +A N G
Sbjct: 2700 AIPSASLSWYKDGQPLKSDD--HVNIAANGH----TLQIKEAQISDTGRYTCVASNIAG 2752
Score = 33.9 bits (76), Expect = 0.45
Identities = 19/93 (20%), Positives = 40/93 (43%), Gaps = 11/93 (11%)
Query: 202 MNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNW- 260
M+++ P I++ V + G ++ C +G P P + W G +++W
Sbjct: 4432 MSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQG--------HSISWD 4483
Query: 261 --TNVHAINLTLVNVTSEDNGFTLTCIAENVVG 291
NV + N + +++ C+A N++G
Sbjct: 4484 DRVNVLSNNSLYIADAQKEDTSEFECVARNLMG 4516
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 76.3 bits (186), Expect = 8e-14
Identities = 67/206 (32%), Positives = 88/206 (42%), Gaps = 16/206 (7%)
Query: 105 LQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLS-LRELQLEQNFFN 163
LQKL + S ++ I+ AF L INL+ N LT L LF L L + L N +N
Sbjct: 245 LQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWN 304
Query: 164 CSCDIRWMQLWQEQGEAKLNSQNLYCI-------NADGSQLPLFRMNISQCDLPEISVSH 216
C+CDI W+ W + + N C N G + N C P I
Sbjct: 305 CNCDILWLSWWIKD----MAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPP 360
Query: 217 VNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQT-NLNWTNVHAINLTLVNVTS 275
+L V EG A + C S S L V WI T ++ TH + + L NVT
Sbjct: 361 ADLNVTEGMAAELKCRASTS-LTSVSWI-TPNGTVMTHGAYKVRIAVLSDGTLNFTNVTV 418
Query: 276 EDNGFTLTCIAENVVGMSNASVALTV 301
+D G TC+ N VG + AS L V
Sbjct: 419 QDTGM-YTCMVSNSVGNTTASATLNV 443
Score = 32.3 bits (72), Expect = 1.3
Identities = 41/151 (27%), Positives = 63/151 (41%), Gaps = 25/151 (16%)
Query: 15 IFLLGSVWLDYVGSVLA--CPANCVCSK--TEINCRRPDDGNLFPLLEGQDSGNSNGNAS 70
+ LL L G V A CP+ C CS +++ C R + L G S
Sbjct: 28 VVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKN-------LREVPDGISTNTRL 80
Query: 71 INITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLR 130
+N+ + I I + +++ L L L + + +R+I+ AF +L
Sbjct: 81 LNLHE--NQIQIIKVNSFKHLRHLEI-----------LQLSRNHIRTIEIGAFNGLANLN 127
Query: 131 YINLSSNRLTTLSWQLFQTLS-LRELQLEQN 160
+ L NRLTT+ F LS L+EL L N
Sbjct: 128 TLELFDNRLTTIPNGAFVYLSKLKELWLRNN 158
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 73.6 bits (179), Expect = 5e-13
Identities = 61/235 (25%), Positives = 105/235 (44%), Gaps = 18/235 (7%)
Query: 79 NITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSG-LRSIQPRAFAKNPHLRYINLSSN 137
++ + I N L +++++ ++ L+K+ N+ L I P AF + P L + L+SN
Sbjct: 285 HLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSN 344
Query: 138 RLTTLSWQLFQTL-SLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQ 196
L+ L ++L +L+E+ + N C C IRWM + + + +L+C++ Q
Sbjct: 345 ALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNM-NKTNIRFMEPDSLFCVDPPEFQ 403
Query: 197 LPLFRMNISQC---DLPEISVSHV-------NLTVREGDNAVITCNGSGSPLPDVDWIVT 246
N+ Q D+ EI + + NL V G C + P P++ WI
Sbjct: 404 ----GQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITP 459
Query: 247 GLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV 301
Q + T + VH+ +N + G TCIA N+VG SV + V
Sbjct: 460 SGQKL-LPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKV 513
Score = 32.7 bits (73), Expect = 1.0
Identities = 32/110 (29%), Positives = 56/110 (50%), Gaps = 4/110 (3%)
Query: 54 FPL-LEGQDSGNSNGNASINITDISR-NITSIHIENWRSLHTLNAVDMELYTGLQKLTIK 111
FP+ L G D +N ++ NI + S+++E L L + + LQ+L I
Sbjct: 90 FPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEE-NKLTELPEKCLSELSNLQELYIN 148
Query: 112 NSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTL-SLRELQLEQN 160
++ L +I P AF +L ++L+SNRL ++ + F L +L L + +N
Sbjct: 149 HNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGEN 198
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 73.6 bits (179), Expect = 5e-13
Identities = 61/235 (25%), Positives = 105/235 (44%), Gaps = 18/235 (7%)
Query: 79 NITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSG-LRSIQPRAFAKNPHLRYINLSSN 137
++ + I N L +++++ ++ L+K+ N+ L I P AF + P L + L+SN
Sbjct: 285 HLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSN 344
Query: 138 RLTTLSWQLFQTL-SLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQ 196
L+ L ++L +L+E+ + N C C IRWM + + + +L+C++ Q
Sbjct: 345 ALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNM-NKTNIRFMEPDSLFCVDPPEFQ 403
Query: 197 LPLFRMNISQC---DLPEISVSHV-------NLTVREGDNAVITCNGSGSPLPDVDWIVT 246
N+ Q D+ EI + + NL V G C + P P++ WI
Sbjct: 404 ----GQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITP 459
Query: 247 GLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV 301
Q + T + VH+ +N + G TCIA N+VG SV + V
Sbjct: 460 SGQKL-LPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKV 513
Score = 32.7 bits (73), Expect = 1.0
Identities = 32/110 (29%), Positives = 56/110 (50%), Gaps = 4/110 (3%)
Query: 54 FPL-LEGQDSGNSNGNASINITDISR-NITSIHIENWRSLHTLNAVDMELYTGLQKLTIK 111
FP+ L G D +N ++ NI + S+++E L L + + LQ+L I
Sbjct: 90 FPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEE-NKLTELPEKCLSELSNLQELYIN 148
Query: 112 NSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTL-SLRELQLEQN 160
++ L +I P AF +L ++L+SNRL ++ + F L +L L + +N
Sbjct: 149 HNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGEN 198
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 73.6 bits (179), Expect = 5e-13
Identities = 61/235 (25%), Positives = 105/235 (44%), Gaps = 18/235 (7%)
Query: 79 NITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSG-LRSIQPRAFAKNPHLRYINLSSN 137
++ + I N L +++++ ++ L+K+ N+ L I P AF + P L + L+SN
Sbjct: 285 HLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSN 344
Query: 138 RLTTLSWQLFQTL-SLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQ 196
L+ L ++L +L+E+ + N C C IRWM + + + +L+C++ Q
Sbjct: 345 ALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNM-NKTNIRFMEPDSLFCVDPPEFQ 403
Query: 197 LPLFRMNISQC---DLPEISVSHV-------NLTVREGDNAVITCNGSGSPLPDVDWIVT 246
N+ Q D+ EI + + NL V G C + P P++ WI
Sbjct: 404 ----GQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITP 459
Query: 247 GLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV 301
Q + T + VH+ +N + G TCIA N+VG SV + V
Sbjct: 460 SGQKL-LPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKV 513
Score = 32.7 bits (73), Expect = 1.0
Identities = 32/110 (29%), Positives = 56/110 (50%), Gaps = 4/110 (3%)
Query: 54 FPL-LEGQDSGNSNGNASINITDISR-NITSIHIENWRSLHTLNAVDMELYTGLQKLTIK 111
FP+ L G D +N ++ NI + S+++E L L + + LQ+L I
Sbjct: 90 FPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEE-NKLTELPEKCLSELSNLQELYIN 148
Query: 112 NSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTL-SLRELQLEQN 160
++ L +I P AF +L ++L+SNRL ++ + F L +L L + +N
Sbjct: 149 HNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGEN 198
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 72.0 bits (175), Expect = 1e-12
Identities = 59/211 (27%), Positives = 91/211 (43%), Gaps = 23/211 (10%)
Query: 103 TGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLS-LRELQLEQNF 161
+ L+KL + NS + I+ AF L +NL+ N L++L LF L L EL L N
Sbjct: 242 SSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNP 301
Query: 162 FNCSCDIRWMQLWQEQ-----------GEAKLNSQNLYCINADGSQLPLFRMNISQCDLP 210
+NC CDI W+ W + A ++ + Y + D + QC P
Sbjct: 302 WNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASF--------QCSAP 353
Query: 211 EISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTL 270
I + +L + EG A + C P+ V W++ ++ + + ++ L
Sbjct: 354 FIMDAPRDLNISEGRMAELKCR--TPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNF 411
Query: 271 VNVTSEDNGFTLTCIAENVVGMSNASVALTV 301
+V D G TC+ NV G SNAS L V
Sbjct: 412 SHVLLSDTG-VYTCMVTNVAGNSNASAYLNV 441
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 71.2 bits (173), Expect = 3e-12
Identities = 54/203 (26%), Positives = 88/203 (43%), Gaps = 6/203 (2%)
Query: 103 TGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLS-LRELQLEQNF 161
T L+KL + ++ + +I+ AF L +NLS N L +L LF L L + L N
Sbjct: 253 TSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNP 312
Query: 162 FNCSCDIRWMQLWQEQGEAKLNSQNLYC---INADGSQLPLFRMNISQCDLPEISVSHVN 218
++C+CD+ W+ W ++ + C G + + C P I +
Sbjct: 313 WHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEPPTD 372
Query: 219 LTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDN 278
L V EG A + C +G+ + V+W+ + + + +H L NVT +D
Sbjct: 373 LNVTEGMAAELKCR-TGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDT 431
Query: 279 GFTLTCIAENVVGMSNASVALTV 301
G TC+ N G + AS L V
Sbjct: 432 G-QYTCMVTNSAGNTTASATLNV 453
Score = 36.6 bits (83), Expect = 0.069
Identities = 24/57 (42%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Query: 105 LQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLS-LRELQLEQN 160
L+ L + + +R I+ AF P L + L NRLTT+ Q F+ LS LREL L N
Sbjct: 112 LEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNN 168
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 71.2 bits (173), Expect = 3e-12
Identities = 62/231 (26%), Positives = 101/231 (43%), Gaps = 10/231 (4%)
Query: 79 NITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSG-LRSIQPRAFAKNPHLRYINLSSN 137
++ + + N L +++ + L KL I N+ L I PRAF P + + L++N
Sbjct: 286 HLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNN 345
Query: 138 RLTTLSWQLFQTL-SLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQ 196
L+ L Q ++L +L+E+ L N C C IRW + L D +
Sbjct: 346 ALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQR 405
Query: 197 LPL----FRMNISQCDLPEISVSHV--NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQS 250
LP+ FR C LP IS +L V G++ V+ C P P++ W+
Sbjct: 406 LPVREVPFREMTDHC-LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLR 464
Query: 251 INTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV 301
+ + L L VT+E+ G TC+A+N+VG +V++ V
Sbjct: 465 LTPAHAGRRYRVYPEGTLELRRVTAEEAGL-YTCVAQNLVGADTKTVSVVV 514
Score = 31.6 bits (70), Expect = 2.2
Identities = 26/95 (27%), Positives = 46/95 (48%), Gaps = 2/95 (2%)
Query: 80 ITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRL 139
+ S+H+E L L LQ+L + ++ L I PRAF+ +L ++L+SN L
Sbjct: 119 LLSLHLEE-NQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLL 177
Query: 140 TTLSWQLFQTL-SLRELQLEQNFFNCSCDIRWMQL 173
+ + F+ L +L L + N + D+ + L
Sbjct: 178 RAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPL 212
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 71.2 bits (173), Expect = 3e-12
Identities = 62/231 (26%), Positives = 101/231 (43%), Gaps = 10/231 (4%)
Query: 79 NITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSG-LRSIQPRAFAKNPHLRYINLSSN 137
++ + + N L +++ + L KL I N+ L I PRAF P + + L++N
Sbjct: 286 HLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNN 345
Query: 138 RLTTLSWQLFQTL-SLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQ 196
L+ L Q ++L +L+E+ L N C C IRW + L D +
Sbjct: 346 ALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQR 405
Query: 197 LPL----FRMNISQCDLPEISVSHV--NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQS 250
LP+ FR C LP IS +L V G++ V+ C P P++ W+
Sbjct: 406 LPVREVPFREMTDHC-LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLR 464
Query: 251 INTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV 301
+ + L L VT+E+ G TC+A+N+VG +V++ V
Sbjct: 465 LTPAHAGRRYRVYPEGTLELRRVTAEEAGL-YTCVAQNLVGADTKTVSVVV 514
Score = 31.6 bits (70), Expect = 2.2
Identities = 26/95 (27%), Positives = 46/95 (48%), Gaps = 2/95 (2%)
Query: 80 ITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRL 139
+ S+H+E L L LQ+L + ++ L I PRAF+ +L ++L+SN L
Sbjct: 119 LLSLHLEE-NQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLL 177
Query: 140 TTLSWQLFQTL-SLRELQLEQNFFNCSCDIRWMQL 173
+ + F+ L +L L + N + D+ + L
Sbjct: 178 RAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPL 212
>gi|15147240 brother of CDO [Homo sapiens]
Length = 1114
Score = 71.2 bits (173), Expect = 3e-12
Identities = 60/210 (28%), Positives = 97/210 (46%), Gaps = 26/210 (12%)
Query: 219 LTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDN 278
+ V +G + ++ C SG P P V W G ++T +N+ L++ TSE++
Sbjct: 240 IIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNL------LIDTTSEED 293
Query: 279 GFTLTCIAENVVGMSNASVAL---TVYYPPRVVSLEEPELRL----EHCIEFVVRGNPPP 331
T C+A+N VG A+V L V+ PP V ++E +L + + VRGNPPP
Sbjct: 294 SGTYRCMADNGVGQPGAAVILYNVQVFEPPEV-TMELSQLVIPWGQSAKLTCEVRGNPPP 352
Query: 332 TLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTI 391
++ WL N PL S Q +S L + G Y +A+N +G+A+ +
Sbjct: 353 SVLWLRNAVPLISS--------QRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVV 404
Query: 392 NGHFLKEPFPESTDNFILFDEVSP-TPPIT 420
L+ P T E++ TPP++
Sbjct: 405 Q---LRTSRPSITPRLWQDAELATGTPPVS 431
Score = 45.4 bits (106), Expect = 1e-04
Identities = 29/102 (28%), Positives = 51/102 (50%), Gaps = 6/102 (5%)
Query: 203 NISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTN 262
N+ + PE+++ L + G +A +TC G+P P V W+ + I++ + L+
Sbjct: 316 NVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLS--- 372
Query: 263 VHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYP 304
L ++++ ED G C+AEN VG ++A V L P
Sbjct: 373 --RRALRVLSMGPEDEG-VYQCMAENEVGSAHAVVQLRTSRP 411
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 69.3 bits (168), Expect = 1e-11
Identities = 58/206 (28%), Positives = 90/206 (43%), Gaps = 13/206 (6%)
Query: 105 LQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQT-LSLRELQLEQNFFN 163
LQ+L I + LR+I+P +F LR +N+S N L TL +F + +L L + N
Sbjct: 299 LQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLA 358
Query: 164 CSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNIS-------QCDLPEISVSH 216
C C + W + Q Q + Q C D + F+ S C P+I
Sbjct: 359 CDCRLLW--ILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKK 416
Query: 217 V-NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTS 275
+ +L V EG + C+ G P P + W+ + I T ++N T + L +
Sbjct: 417 LQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITT-KSNGRATVLGDGTLEIRFAQD 475
Query: 276 EDNGFTLTCIAENVVGMSNASVALTV 301
+D+G CIA N G + +LTV
Sbjct: 476 QDSGM-YVCIASNAAGNDTFTASLTV 500
Score = 52.4 bits (124), Expect = 1e-06
Identities = 54/215 (25%), Positives = 97/215 (45%), Gaps = 29/215 (13%)
Query: 11 SFWRIFLLGSVWLDYVGSVLACPANCVCS--KTEINCRRPDDGNLFPLLEGQDSGNSNGN 68
S W+ FL +V L ++GS + CPA C CS ++C R L + EG
Sbjct: 7 SCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHR---RRLIAIPEGIP------- 56
Query: 69 ASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPH 128
I D+S+N L ++N + Y L+++ + ++ + +++P AF +
Sbjct: 57 IETKILDLSKN----------RLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFN 106
Query: 129 LRYINLSSNRLTTLSWQLFQTLS-LRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNL 187
LR + L NRL + +F LS L +L + +N D + L ++ +L
Sbjct: 107 LRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDL-HNLKSLEVGDNDL 165
Query: 188 YCIN--ADGSQLPLFRMNISQCDL---PEISVSHV 217
I+ A L L ++ + +C+L P ++SH+
Sbjct: 166 VYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHL 200
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 68.6 bits (166), Expect = 2e-11
Identities = 56/216 (25%), Positives = 89/216 (41%), Gaps = 15/216 (6%)
Query: 190 INADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQ 249
+N G + +N+ + + SH LTVREG ++C G P P + W G Q
Sbjct: 953 LNQAGRSEKHYNLNVWVAPVFPLRESHT-LTVREGHPTSLSCECRGVPFPKISWRKDG-Q 1010
Query: 250 SINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVS 309
+ L + L L G T TC NVVG S+ + L V+ PP++
Sbjct: 1011 PLPGEGAGLQHVSAVGRLLYLGQAQLAQEG-TYTCECSNVVGNSSQDLQLEVHVPPQIAG 1069
Query: 310 LEEPELRLE------HCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCL 363
EP ++ +E G PPPT+ W +GQP+ + ++ +G+ L
Sbjct: 1070 PREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAE--LGLQLQNQGQ----SL 1123
Query: 364 LFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEP 399
+ + G Y+ +A+N G A + L P
Sbjct: 1124 HVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPP 1159
Score = 65.9 bits (159), Expect = 1e-10
Identities = 53/196 (27%), Positives = 91/196 (46%), Gaps = 19/196 (9%)
Query: 201 RMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNW 260
R++++ LP + + ++R GD + C GSP P + W V + + + +
Sbjct: 2929 RVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVND-RPVTEGVSEQDG 2987
Query: 261 TNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHC 320
+ L V+ ED+G T C AEN VG + A + V P V+ E +E
Sbjct: 2988 GST----LQRAAVSREDSG-TYVCWAENRVGRTQAVSFVHVKEAP-VLQGEAFSYLVEPV 3041
Query: 321 -----IEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGN 375
++ VVRG+P P +HW+ +G PLR S + H ++ G L ++ + G
Sbjct: 3042 GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRH-------QLQNGSLTIHRTERDDAGR 3094
Query: 376 YTLIAKNPLGTANQTI 391
Y +A+N +G A + +
Sbjct: 3095 YQCLAENEMGVAKKVV 3110
Score = 65.1 bits (157), Expect = 2e-10
Identities = 61/226 (26%), Positives = 95/226 (42%), Gaps = 39/226 (17%)
Query: 179 EAKLNSQNLYCI---NADGSQLPLFRMNISQCDLPEISVSHVNLTVRE--GDNAVITCNG 233
EA+++ + LY N G + F + + +P + TV + G V+TC+
Sbjct: 1901 EAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ---VPPTFENPKTETVSQVAGSPLVLTCDV 1957
Query: 234 SGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAI-----NLTLVNVTSEDNGFTLTCIAEN 288
SG P P V W+ + + + VH + L L + G T TC+AEN
Sbjct: 1958 SGVPAPTVTWLKDRMP--------VESSAVHGVVSRGGRLQLSRLQPAQAG-TYTCVAEN 2008
Query: 289 VVGMSNASVALTVYYPPRVVS---------LEEPELRLEHCIEFVVRGNPPPTLHWLHNG 339
+ + V PR+ S LE E+RL+ + G PPP + WL +G
Sbjct: 2009 TQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEAD----GQPPPDVAWLKDG 2064
Query: 340 QPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLG 385
PL + H+ +Y +G G L+ + G YT +A NP G
Sbjct: 2065 SPLGQDMGPHLRFYLDG----GSLVLKGLRASDAGAYTCVAHNPAG 2106
Score = 64.7 bits (156), Expect = 2e-10
Identities = 47/168 (27%), Positives = 77/168 (45%), Gaps = 17/168 (10%)
Query: 224 GDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLT 283
G + + C G P+PD+ WI GL +H + + +LT ++ T D+
Sbjct: 3042 GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRH----QLQNGSLT-IHRTERDDAGRYQ 3096
Query: 284 CIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPTLHWLHNG 339
C+AEN +G++ V L + P V +E ++ + + +R G P PT+ WL G
Sbjct: 3097 CLAENEMGVAKKVVILVLQSAP-VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAG 3155
Query: 340 QPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTA 387
QPLR S+ + + +G L + G Y +A N LG+A
Sbjct: 3156 QPLRASRRLRT-------LPDGSLWLENVETGDAGTYDCVAHNLLGSA 3196
Score = 64.3 bits (155), Expect = 3e-10
Identities = 50/175 (28%), Positives = 74/175 (42%), Gaps = 16/175 (9%)
Query: 219 LTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDN 278
+ V E + C G P P++ W G ++ T + +T L L S D
Sbjct: 321 VAVMEDHLVQLLCEARGVPTPNITWFKDG--ALLPTSTKVVYTR-GGRQLQLGRAQSSDA 377
Query: 279 GFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEH------CIEFVVRGNPPPT 332
G TC A N VG + + L VY PP + ++ +E V RG+P PT
Sbjct: 378 G-VYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPT 436
Query: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTA 387
L W H G P+ ES +E +G + L P ++G Y+ +A +P G A
Sbjct: 437 LSWHHEGLPVAESNESRLE--TDGSV----LRLESPGEASSGLYSCVASSPAGEA 485
Score = 59.7 bits (143), Expect = 8e-09
Identities = 51/190 (26%), Positives = 75/190 (39%), Gaps = 20/190 (10%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNW----TNVHA 265
P I VN V E + + C SG P PDV W HQ +W +V
Sbjct: 695 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSW-------FKGHQPVSSWMGVTVSVDG 747
Query: 266 INLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVV---SLEEPEL-RLEHCI 321
L + D G + C+A NV G + L V PPR+ SL P L +
Sbjct: 748 RVLRIEQAQLSDAG-SYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRL 806
Query: 322 EFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAK 381
G P PTL WL +G P+ + ++ + G + L ++G Y+ +A
Sbjct: 807 TCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV----LTLASARASDSGRYSCVAV 862
Query: 382 NPLGTANQTI 391
+ +G Q +
Sbjct: 863 SAVGEDRQDV 872
Score = 58.2 bits (139), Expect = 2e-08
Identities = 50/164 (30%), Positives = 77/164 (46%), Gaps = 11/164 (6%)
Query: 186 NLYCI--NADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
N CI N+ GS + R+ + P I +L+ EG +A + C GSP P++ W
Sbjct: 2823 NYLCIAKNSAGSAMGKTRLVVQVP--PVIENGLPDLSTTEGSHAFLPCKARGSPEPNITW 2880
Query: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
G Q ++ + +T + L + N+ +D G T TC AEN VG + V LT+
Sbjct: 2881 DKDG-QPVSGAEG--KFTIQPSGELLVKNLEGQDAG-TYTCTAENAVGRARRRVHLTILV 2936
Query: 304 PPRVVSLE-EPELRL--EHCIEFVVRGNPPPTLHWLHNGQPLRE 344
P +L + LRL + RG+P P + W N +P+ E
Sbjct: 2937 LPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTE 2980
Score = 57.8 bits (138), Expect = 3e-08
Identities = 49/193 (25%), Positives = 82/193 (42%), Gaps = 14/193 (7%)
Query: 229 ITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAEN 288
+TCN +G+P P + W+ G L + LTL + + D+G +C+A +
Sbjct: 806 LTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV-LTLASARASDSG-RYSCVAVS 863
Query: 289 VVGMSNASVALTVYYPPRVVSLEEPELRL----EHCIEFVVRGNPPPTLHWLHNGQPLRE 344
VG V L V+ PP ++ EE + + +E PPP L W +G+PL
Sbjct: 864 AVGEDRQDVVLQVHMPPSILG-EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEP 922
Query: 345 SKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEP-FPES 403
+H+ + L ++ ++ G+YT A N G + + N + P FP
Sbjct: 923 RPGVHL------SADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLR 976
Query: 404 TDNFILFDEVSPT 416
+ + E PT
Sbjct: 977 ESHTLTVREGHPT 989
Score = 55.1 bits (131), Expect = 2e-07
Identities = 60/236 (25%), Positives = 99/236 (41%), Gaps = 38/236 (16%)
Query: 179 EAKLNSQNLY-CI--NADGSQLPLFRMNISQCDLPEI-----SVSHVNLTVREGDNAVIT 230
+A L+S Y CI NA G + F++++ P I + +TV + +
Sbjct: 1314 QANLSSAGHYSCIAANAVGEKTKHFQLSVLLA--PTILGGAEDSADEEVTVTVNNPISLI 1371
Query: 231 CNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVV 290
C P P++ W+ G + L H L ++N ED G TC+ N +
Sbjct: 1372 CEALAFPSPNITWMKDGAPFEASRNIQL-LPGTHG--LQILNAQKEDAG-QYTCVVTNEL 1427
Query: 291 GMSNASVALTVYYPPRV--------VSLEEPELRLE-----HCIEFVVRGNPPPTLHWLH 337
G + + + V PP + V ++E + ++ C + V PPPT+ W
Sbjct: 1428 GEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAV---PPPTIRWYK 1484
Query: 338 NGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHY-NNGNYTLIAKNPLGTANQTIN 392
+GQP+ S + V + EG LL +PT ++G Y +A N G +Q N
Sbjct: 1485 DGQPVTPSSRLQV-------LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFN 1533
Score = 53.1 bits (126), Expect = 7e-07
Identities = 60/243 (24%), Positives = 101/243 (41%), Gaps = 26/243 (10%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
P I+ S NLT+ A++ C SGSP P V W G Q ++ + + N
Sbjct: 2573 PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDG-QKLD-FRLQQGAYRLLPSNAL 2630
Query: 270 LVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVV---- 325
L+ + C+ N VG ++ +TV+ PP + ++ + + V+
Sbjct: 2631 LLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIAD-DQTDFTVTMMAPVVLTCHS 2689
Query: 326 RGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLG 385
G P PT+ W G L ++ G + G L P H G YT A+N G
Sbjct: 2690 TGIPAPTVSWSKAGAQL-GARGSGYRVSPSGALEIGQAL---PIH--AGRYTCSARNSAG 2743
Query: 386 TANQ----TINGHFLKEPFPE-----STDNFILFDEVSPTPPITVTHKPEEDTFGVSIAV 436
A++ T+ + +P P + + +L E S P T+T + E G+++A
Sbjct: 2744 VAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKE----GLNVAT 2799
Query: 437 GLA 439
G++
Sbjct: 2800 GVS 2802
Score = 53.1 bits (126), Expect = 7e-07
Identities = 46/175 (26%), Positives = 73/175 (41%), Gaps = 22/175 (12%)
Query: 225 DNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTC 284
+ ++ C SG P P + W GL T + + L + + + ED G L C
Sbjct: 2772 EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQV----LPGGQLRIAHASPEDAGNYL-C 2826
Query: 285 IAENVVGMSNASVALTVYYPPRVVSLEEPELRLEH----CIEFVVRGNPPPTLHWLHNGQ 340
IA+N G + L V PP V+ P+L + RG+P P + W +GQ
Sbjct: 2827 IAKNSAGSAMGKTRLVVQVPP-VIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQ 2885
Query: 341 PLRESKIIHVEYYQEGEIS---EGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
P+ + EG+ + G LL + G YT A+N +G A + ++
Sbjct: 2886 PVSGA---------EGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVH 2931
Score = 50.8 bits (120), Expect = 4e-06
Identities = 52/241 (21%), Positives = 99/241 (41%), Gaps = 26/241 (10%)
Query: 178 GEAKLNSQNLY---CINADGSQLPLFRMNISQCDLPEISVSH---VNLTVREGDNAVITC 231
G+A+L + Y C N G+ ++ + P+I+ ++V + A + C
Sbjct: 1032 GQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVP--PQIAGPREPPTQVSVVQDGVATLEC 1089
Query: 232 NGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG 291
N +G P P V W G Q + + L N +L + + G +C+AEN+ G
Sbjct: 1090 NATGKPPPTVTWERDG-QPVGA-ELGLQLQN-QGQSLHVERAQAAHTG-RYSCVAENLAG 1145
Query: 292 MSNASVALTVYYPPRVVSLEEPELRLEHCIEFVV------RGNPPPTLHWLHNGQPLRES 345
+ L+V PP ++ +P + + + G PPP + W +P+
Sbjct: 1146 RAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPG 1205
Query: 346 KIIHVEYYQEGEISEGCLL-FNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPEST 404
+ ++ ++ G +L + ++G Y+ +A N G A + + L P E+
Sbjct: 1206 EDTYL-------LAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENE 1258
Query: 405 D 405
D
Sbjct: 1259 D 1259
Score = 50.4 bits (119), Expect = 5e-06
Identities = 44/194 (22%), Positives = 80/194 (41%), Gaps = 22/194 (11%)
Query: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLN 259
F++ + + E S L++ G + C+ G+P P++ W G Q++ + N
Sbjct: 2295 FQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG-QALTRLENNSR 2353
Query: 260 WTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRL-- 317
T V + D G TC+AE+ G S + V PP +V P +
Sbjct: 2354 ATRVLRVR---------DAGL-YTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGL 2403
Query: 318 ---EHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNG 374
+ +E V P P + W +G L+E H ++ + G L + ++G
Sbjct: 2404 APGQLVLECSVEAEPAPKITWHRDGIVLQED--AHTQFPERGRF----LQLQALSTADSG 2457
Query: 375 NYTLIAKNPLGTAN 388
+Y+ A+N G+ +
Sbjct: 2458 DYSCTARNAAGSTS 2471
Score = 48.9 bits (115), Expect = 1e-05
Identities = 58/230 (25%), Positives = 89/230 (38%), Gaps = 37/230 (16%)
Query: 178 GEAKLNSQNLY---CINADGSQLPLFRMNISQCDL-------PEISVSHVNLTVREGDNA 227
G A+L+ +Y +NA G L ++++ P+ +V VR GD A
Sbjct: 1805 GRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAV-----LVRVGDKA 1859
Query: 228 VITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAE 287
V++C P P V W G + +T L + D G +C
Sbjct: 1860 VLSCETDALPEPTVTWYKDGQPLVLAQRTQ---ALRGGQRLEIQEAQVSDKGL-YSCKVS 1915
Query: 288 NVVGMSNASVALTVYYPPRVVSLEEPELRLEH-------CIEFVVRGNPPPTLHWLHNGQ 340
NV G + + LTV PP + E P+ + V G P PT+ WL +
Sbjct: 1916 NVAGEAVRTFTLTVQVPP---TFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRM 1972
Query: 341 PLRESKIIHVEYYQEGEISE-GCLLFNKPTHYNNGNYTLIAKNPLGTANQ 389
P+ ES +H G +S G L ++ G YT +A+N A +
Sbjct: 1973 PV-ESSAVH------GVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARK 2015
Score = 47.8 bits (112), Expect = 3e-05
Identities = 47/177 (26%), Positives = 73/177 (41%), Gaps = 18/177 (10%)
Query: 221 VREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGF 280
V EG + C G P PDV W+ G +L + + +L L + + D G
Sbjct: 2038 VLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY-LDGGSLVLKGLRASDAG- 2095
Query: 281 TLTCIAENVVGMSNASVALTVYYPPRVVSLEEPE----LRLEHCIEFV--VRGNPPPTLH 334
TC+A N G + V PP + + R + V VRG+PP +
Sbjct: 2096 AYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVS 2155
Query: 335 WLHNGQPLRESK--IIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQ 389
WL +G PL S+ ++H S L +K + G +T +A +P G A++
Sbjct: 2156 WLKDGLPLPLSQRTLLHG--------SGHTLRISKVQLADAGIFTCVAASPAGVADR 2204
Score = 47.8 bits (112), Expect = 3e-05
Identities = 29/97 (29%), Positives = 47/97 (48%), Gaps = 5/97 (5%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
P V ++TVR GD+ + C +G P P ++W LQ+ + + + +L
Sbjct: 3118 PVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEW----LQAGQPLRASRRLRTLPDGSLW 3173
Query: 270 LVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPR 306
L NV + D G T C+A N++G + A L V P+
Sbjct: 3174 LENVETGDAG-TYDCVAHNLLGSATARAFLVVRGEPQ 3209
Score = 47.0 bits (110), Expect = 5e-05
Identities = 45/194 (23%), Positives = 80/194 (41%), Gaps = 25/194 (12%)
Query: 219 LTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDN 278
L R G+ + C GSP V W+ GL + +T L+ + H + ++ V + D
Sbjct: 2132 LVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSG-HTLRISKVQLA--DA 2188
Query: 279 GFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCI--------EFVVRGNPP 330
G TC+A + G+++ + L V PP LE E + + + RG P
Sbjct: 2189 GI-FTCVAASPAGVADRNFTLQVQVPP---VLEPVEFQNDVVVVRGSLVELPCEARGVPL 2244
Query: 331 PTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQT 390
P + W+ +G+PL + Q + G ++G Y+ +A + G A +
Sbjct: 2245 PLVSWMKDGEPLLSQSLEQGPSLQLEAVGAG----------DSGTYSCVAVSEAGEARRH 2294
Query: 391 INGHFLKEPFPEST 404
++ P E +
Sbjct: 2295 FQLTVMEPPHIEDS 2308
Score = 44.7 bits (104), Expect = 3e-04
Identities = 41/174 (23%), Positives = 72/174 (41%), Gaps = 17/174 (9%)
Query: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277
N+T + C G P P + W G + ++ + + +T T E
Sbjct: 1170 NITAALHSPLTLLCEAMGIPPPAIRWF-RGEEPVSPGEDTYLLAGGWMLKMTQ---TQEQ 1225
Query: 278 NGFTLTCIAENVVGMSNASVALTVYYPPRVVS--LEEPELRLEHCIEFV---VRGNPPPT 332
+ +C+A N G + + ++ V PP + + LEE L+ + V G+P P
Sbjct: 1226 DSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPK 1285
Query: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNN-GNYTLIAKNPLG 385
L W +G+PL H+ +G LL + ++ G+Y+ IA N +G
Sbjct: 1286 LTWFKDGRPLARGDAHHIS-------PDGVLLQVLQANLSSAGHYSCIAANAVG 1332
Score = 43.1 bits (100), Expect = 7e-04
Identities = 44/185 (23%), Positives = 74/185 (40%), Gaps = 40/185 (21%)
Query: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277
++ V G + C G PLP V W+ G + L+ + +L L V + D
Sbjct: 2224 DVVVVRGSLVELPCEARGVPLPLVSWMKDG-------EPLLSQSLEQGPSLQLEAVGAGD 2276
Query: 278 NGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEP-ELRLEHCIEFVV----RGNPPPT 332
+G T +C+A + G + LTV PP + +P EL L + +G P P
Sbjct: 2277 SG-TYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPN 2335
Query: 333 LHWLHNGQPL-------RESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLG 385
+ W +GQ L R ++++ V + G YT +A++P G
Sbjct: 2336 ITWHKDGQALTRLENNSRATRVLRVR--------------------DAGLYTCLAESPAG 2375
Query: 386 TANQT 390
++
Sbjct: 2376 AIEKS 2380
Score = 42.7 bits (99), Expect = 0.001
Identities = 41/174 (23%), Positives = 70/174 (40%), Gaps = 17/174 (9%)
Query: 223 EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
E + A + C+ + P PD+ W Q ++ + + LV +N
Sbjct: 1573 ENNPAYLYCDTNAIPPPDLTWYRED-QPLSAGDEVSVLQGGRVLQIPLVRA---ENAGRY 1628
Query: 283 TCIAENVVGMSNASVALTVYYPPRVVS-----LEEPELRLEHCIEFV--VRGNPPPTLHW 335
+C A N VG L V PP ++ +EE + + GNP PT+ W
Sbjct: 1629 SCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW 1688
Query: 336 LHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQ 389
L NG P S + V ++G++ L + + +Y +A+N G+A +
Sbjct: 1689 LQNGLPFSPSPRLQV--LEDGQV----LQVSTAEVADAASYMCVAENQAGSAEK 1736
Score = 42.4 bits (98), Expect = 0.001
Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 10/122 (8%)
Query: 268 LTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHC---IEFV 324
L + V D G TC A N+ G S VAL V PP + + LE+ +E +
Sbjct: 659 LQIEKVDLRDEGI-YTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECL 717
Query: 325 VRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPL 384
G PPP + W QP+ S + V +G + L + + G+Y +A N
Sbjct: 718 ASGVPPPDVSWFKGHQPV--SSWMGVTVSVDGRV----LRIEQAQLSDAGSYRCVASNVA 771
Query: 385 GT 386
G+
Sbjct: 772 GS 773
Score = 42.4 bits (98), Expect = 0.001
Identities = 28/128 (21%), Positives = 51/128 (39%), Gaps = 8/128 (6%)
Query: 219 LTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDN 278
+TV + C G+P+P + W+ GL + + + + + V+ +
Sbjct: 1664 VTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQV----LEDGQVLQVSTAEVAD 1719
Query: 279 GFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPE----LRLEHCIEFVVRGNPPPTLH 334
+ C+AEN G + L V PPR+ L+ + L + V +P P +
Sbjct: 1720 AASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT 1779
Query: 335 WLHNGQPL 342
W + Q L
Sbjct: 1780 WYKDSQAL 1787
Score = 41.6 bits (96), Expect = 0.002
Identities = 38/174 (21%), Positives = 70/174 (40%), Gaps = 17/174 (9%)
Query: 224 GDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLT 283
G + C G P P + W GL ++++ L ++ + E + +
Sbjct: 420 GRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDG----SVLRLESPGEASSGLYS 475
Query: 284 CIAENVVGMSNASVALTVYYPPRVVSLE---EPELRLEHCIEFVVR--GNPPPTLHWLHN 338
C+A + G + ++ V PP+++ E + + +E + G+P PT+ WL N
Sbjct: 476 CVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQN 535
Query: 339 GQPLRESKIIHVEYYQEGEISEGCLLFNKPTHY-NNGNYTLIAKNPLGTANQTI 391
G+P E + V S+G L ++G + A N GTA +
Sbjct: 536 GRPAEELAGVQV-------ASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 582
Score = 41.6 bits (96), Expect = 0.002
Identities = 49/224 (21%), Positives = 82/224 (36%), Gaps = 14/224 (6%)
Query: 169 RWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAV 228
R++QL Q A + NA GS FR+ I VN++V + A+
Sbjct: 2444 RFLQL-QALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQ--TAL 2500
Query: 229 ITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAEN 288
+ C G P P V W + + + + +L + V ++D G L C+A N
Sbjct: 2501 LPCQADGVPAPLVSW---RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL-CLASN 2556
Query: 289 VVGMSNASVALTVYYPPRVVSLEEPELRLEH---CIEFVVRGNPPPTLHWLHNGQPLRES 345
G L V PP + H + G+P P + W +GQ L
Sbjct: 2557 SAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLD-- 2614
Query: 346 KIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQ 389
++ + LL P ++ + + N +G A++
Sbjct: 2615 --FRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHR 2656
Score = 40.0 bits (92), Expect = 0.006
Identities = 60/246 (24%), Positives = 98/246 (39%), Gaps = 25/246 (10%)
Query: 109 TIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDI 168
TI+ +G R +A A P + TLSW + L + E N D
Sbjct: 404 TIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWH-HEGLPVAE----SNESRLETDG 458
Query: 169 RWMQLWQEQGEAKLNSQNLY-CINADGSQLPLFRMNISQCDLPEISVSHV--NLTVREGD 225
++L + GEA S LY C+ + + + + ++ P++ V+ +T G
Sbjct: 459 SVLRL-ESPGEA---SSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQ 514
Query: 226 NAVITCNGSGSPLPDVDWIVTG--LQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLT 283
+ C SGSP+P + W+ G + + Q T +H ++ L D+
Sbjct: 515 PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVEL------DHSGLFA 568
Query: 284 CIAENVVGMSNASVALTVY--YPPRV--VSLEEPELRLEHCIEFVVRGNPPPTLHW-LHN 338
C A N G + A V ++V+ + P V V + + EH F +PP W H
Sbjct: 569 CQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHP 628
Query: 339 GQPLRE 344
PL E
Sbjct: 629 KPPLVE 634
Score = 35.0 bits (79), Expect = 0.20
Identities = 38/178 (21%), Positives = 68/178 (38%), Gaps = 28/178 (15%)
Query: 224 GDNAVITCNGSGSPLPDVDW------IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277
G + + C SG P P V+W ++ G + + + +T +V E
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDG------QVLRITGSHVGDEG 285
Query: 278 NGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEP---ELRLEHCIEFV--VRGNPPPT 332
C+A + G L V+ PP + E + +H ++ + RG P P
Sbjct: 286 R---YQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPN 342
Query: 333 LHWLHNGQPLRES-KIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQ 389
+ W +G L S K+++ ++ L + + G YT A N +G A +
Sbjct: 343 ITWFKDGALLPTSTKVVYTRGGRQ-------LQLGRAQSSDAGVYTCKASNAVGAAEK 393
Score = 34.7 bits (78), Expect = 0.26
Identities = 44/191 (23%), Positives = 70/191 (36%), Gaps = 22/191 (11%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
P I +N++V ++ + C P P + W G +L + +
Sbjct: 880 PSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHL------SADKA 933
Query: 270 LVNVTSED--NGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEH----CIEF 323
L+ V D + TC A N G S L V+ P E L + +
Sbjct: 934 LLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSC 993
Query: 324 VVRGNPPPTLHWLHNGQPL--RESKIIHVEYYQEGEISEGCLLF-NKPTHYNNGNYTLIA 380
RG P P + W +GQPL + + HV + G LL+ + G YT
Sbjct: 994 ECRGVPFPKISWRKDGQPLPGEGAGLQHVS-------AVGRLLYLGQAQLAQEGTYTCEC 1046
Query: 381 KNPLGTANQTI 391
N +G ++Q +
Sbjct: 1047 SNVVGNSSQDL 1057
Score = 30.8 bits (68), Expect = 3.8
Identities = 33/118 (27%), Positives = 46/118 (38%), Gaps = 14/118 (11%)
Query: 231 CNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVV 290
C G+P P V W G S H + +L L +V+ D+G C A N V
Sbjct: 24 CGTHGTPKPQVTWR-KGPSSEPLHGQP-GVAVLEEGSLFLASVSPADSG-DYECQATNEV 80
Query: 291 GMSNASVALTVYYPPRVVSLEEPELRL--------EHCIEFVVRGNPPPTLHWLHNGQ 340
G ++ L VY PP S+ E + +E G P P + WL + Q
Sbjct: 81 GSTSRRAKLVVYVPP---SIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQ 135
Score = 29.6 bits (65), Expect = 8.5
Identities = 45/207 (21%), Positives = 68/207 (32%), Gaps = 36/207 (17%)
Query: 203 NISQCD-LPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWT 261
+IS+ D L E+ V V V + C P P + W G + + +
Sbjct: 1443 SISKDDPLGEVGVKEVKTKVNS--TLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGE 1500
Query: 262 NVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPP------------RVVS 309
L + T + C+A NV G + + + PP ++S
Sbjct: 1501 G----RLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILS 1556
Query: 310 LEEPELRLEHCIEFVVRGN-----------PPPTLHWLHNGQPLRESKIIHVEYYQEGEI 358
EE +V N PPP L W QPL V Q G +
Sbjct: 1557 REEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGD--EVSVLQGGRV 1614
Query: 359 SEGCLLFNKPTHYNNGNYTLIAKNPLG 385
+ L+ + N G Y+ A N +G
Sbjct: 1615 LQIPLVRAE----NAGRYSCKASNEVG 1637
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 68.6 bits (166), Expect = 2e-11
Identities = 56/216 (25%), Positives = 89/216 (41%), Gaps = 15/216 (6%)
Query: 190 INADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQ 249
+N G + +N+ + + SH LTVREG ++C G P P + W G Q
Sbjct: 2144 LNQAGHSEKHYNLNVWVAPVFPLRESHT-LTVREGHPTSLSCECRGVPFPKISWRKDG-Q 2201
Query: 250 SINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVS 309
+ L + L L G T TC NVVG S+ + L V+ PP++
Sbjct: 2202 PLPGEGAGLQHVSAVGRLLYLGQAQLAQEG-TYTCECSNVVGNSSQDLQLEVHVPPQIAG 2260
Query: 310 LEEPELRLE------HCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCL 363
EP ++ +E G PPPT+ W +GQP+ + ++ +G+ L
Sbjct: 2261 PREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAE--LGLQLQNQGQ----SL 2314
Query: 364 LFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEP 399
+ + G Y+ +A+N G A + L P
Sbjct: 2315 HVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPP 2350
Score = 65.9 bits (159), Expect = 1e-10
Identities = 53/196 (27%), Positives = 91/196 (46%), Gaps = 19/196 (9%)
Query: 201 RMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNW 260
R++++ LP + + ++R GD + C GSP P + W V + + + +
Sbjct: 4120 RVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVND-RPVTEGVSEQDG 4178
Query: 261 TNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHC 320
+ L V+ ED+G T C AEN VG + A + V P V+ E +E
Sbjct: 4179 GST----LQRAAVSREDSG-TYVCWAENRVGRTQAVSFVHVKEAP-VLQGEAFSYLVEPV 4232
Query: 321 -----IEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGN 375
++ VVRG+P P +HW+ +G PLR S + H ++ G L ++ + G
Sbjct: 4233 GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRH-------QLQNGSLTIHRTERDDAGR 4285
Query: 376 YTLIAKNPLGTANQTI 391
Y +A+N +G A + +
Sbjct: 4286 YQCLAENEMGVAKKVV 4301
Score = 65.1 bits (157), Expect = 2e-10
Identities = 61/226 (26%), Positives = 95/226 (42%), Gaps = 39/226 (17%)
Query: 179 EAKLNSQNLYCI---NADGSQLPLFRMNISQCDLPEISVSHVNLTVRE--GDNAVITCNG 233
EA+++ + LY N G + F + + +P + TV + G V+TC+
Sbjct: 3092 EAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ---VPPTFENPKTETVSQVAGSPLVLTCDV 3148
Query: 234 SGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAI-----NLTLVNVTSEDNGFTLTCIAEN 288
SG P P V W+ + + + VH + L L + G T TC+AEN
Sbjct: 3149 SGVPAPTVTWLKDRMP--------VESSAVHGVVSRGGRLQLSRLQPAQAG-TYTCVAEN 3199
Query: 289 VVGMSNASVALTVYYPPRVVS---------LEEPELRLEHCIEFVVRGNPPPTLHWLHNG 339
+ + V PR+ S LE E+RL+ + G PPP + WL +G
Sbjct: 3200 TQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEAD----GQPPPDVAWLKDG 3255
Query: 340 QPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLG 385
PL + H+ +Y +G G L+ + G YT +A NP G
Sbjct: 3256 SPLGQDMGPHLRFYLDG----GSLVLKGLRASDAGAYTCVAHNPAG 3297
Score = 64.7 bits (156), Expect = 2e-10
Identities = 47/168 (27%), Positives = 77/168 (45%), Gaps = 17/168 (10%)
Query: 224 GDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLT 283
G + + C G P+PD+ WI GL +H + + +LT ++ T D+
Sbjct: 4233 GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRH----QLQNGSLT-IHRTERDDAGRYQ 4287
Query: 284 CIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPTLHWLHNG 339
C+AEN +G++ V L + P V +E ++ + + +R G P PT+ WL G
Sbjct: 4288 CLAENEMGVAKKVVILVLQSAP-VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAG 4346
Query: 340 QPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTA 387
QPLR S+ + + +G L + G Y +A N LG+A
Sbjct: 4347 QPLRASRRLRT-------LPDGSLWLENVETGDAGTYDCVAHNLLGSA 4387
Score = 64.3 bits (155), Expect = 3e-10
Identities = 50/175 (28%), Positives = 74/175 (42%), Gaps = 16/175 (9%)
Query: 219 LTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDN 278
+ V E + C G P P++ W G ++ T + +T L L S D
Sbjct: 1512 VAVMEDHLVQLLCEARGVPTPNITWFKDG--ALLPTSTKVVYTR-GGRQLQLGRAQSSDA 1568
Query: 279 GFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEH------CIEFVVRGNPPPT 332
G TC A N VG + + L VY PP + ++ +E V RG+P PT
Sbjct: 1569 G-VYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPT 1627
Query: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTA 387
L W H G P+ ES +E +G + L P ++G Y+ +A +P G A
Sbjct: 1628 LSWHHEGLPVAESNESRLE--TDGSV----LRLESPGEASSGLYSCVASSPAGEA 1676
Score = 60.8 bits (146), Expect = 3e-09
Identities = 55/240 (22%), Positives = 97/240 (40%), Gaps = 16/240 (6%)
Query: 174 WQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNG 233
W+ +K C + + I D P V N+TV G+ AV++C
Sbjct: 481 WEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRV 540
Query: 234 SGSPLPDVDWIVT-GLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGM 292
G ++ W+ + +T + + ++L + + D G C+A N G+
Sbjct: 541 LGEAPYNLTWVRDWRVLPASTGRV----AQLADLSLEISGIIPTDGG-RYQCVASNANGV 595
Query: 293 SNASVALTVYYPPRV---VSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIH 349
+ ASV L V P+V S + +E + G P P + W Q L+E IH
Sbjct: 596 TRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH 655
Query: 350 VEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFIL 409
V+ ++G L+ + GNY+ A N +GT +T+ ++ P + + +L
Sbjct: 656 VD-------AQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL 708
Score = 59.7 bits (143), Expect = 8e-09
Identities = 51/190 (26%), Positives = 75/190 (39%), Gaps = 20/190 (10%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNW----TNVHA 265
P I VN V E + + C SG P PDV W HQ +W +V
Sbjct: 1886 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSW-------FKGHQPVSSWMGVTVSVDG 1938
Query: 266 INLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVV---SLEEPEL-RLEHCI 321
L + D G + C+A NV G + L V PPR+ SL P L +
Sbjct: 1939 RVLRIEQAQLSDAG-SYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRL 1997
Query: 322 EFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAK 381
G P PTL WL +G P+ + ++ + G + L ++G Y+ +A
Sbjct: 1998 TCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV----LTLASARASDSGRYSCVAV 2053
Query: 382 NPLGTANQTI 391
+ +G Q +
Sbjct: 2054 SAVGEDRQDV 2063
Score = 58.5 bits (140), Expect = 2e-08
Identities = 56/226 (24%), Positives = 89/226 (39%), Gaps = 16/226 (7%)
Query: 177 QGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGS 236
QG A ++ N C + + + D P +S + + V G+ AV+ C SG
Sbjct: 665 QGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGV 724
Query: 237 PLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNAS 296
P P V W GL+ I + + + + E + T TC A N +G ++A
Sbjct: 725 PPPRVIWYRGGLEMILAPEGS-------SSGKLRIPAAQERDAGTYTCRAVNELGDASAE 777
Query: 297 VALTVYYPPRVVSLEEP---ELRLEHCIEFVVRGNPPPTLHWLH-NGQPLRESKIIHVEY 352
+ L V + P++ L EL + G PPPT+ W +GQPL ++
Sbjct: 778 IQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPL-GLRLGAGRG 836
Query: 353 YQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLG----TANQTINGH 394
+ + G L F + Y A+N G A + GH
Sbjct: 837 SRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGH 882
Score = 58.2 bits (139), Expect = 2e-08
Identities = 50/164 (30%), Positives = 77/164 (46%), Gaps = 11/164 (6%)
Query: 186 NLYCI--NADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
N CI N+ GS + R+ + P I +L+ EG +A + C GSP P++ W
Sbjct: 4014 NYLCIAKNSAGSAMGKTRLVVQVP--PVIENGLPDLSTTEGSHAFLPCKARGSPEPNITW 4071
Query: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
G Q ++ + +T + L + N+ +D G T TC AEN VG + V LT+
Sbjct: 4072 DKDG-QPVSGAEG--KFTIQPSGELLVKNLEGQDAG-TYTCTAENAVGRARRRVHLTILV 4127
Query: 304 PPRVVSLE-EPELRL--EHCIEFVVRGNPPPTLHWLHNGQPLRE 344
P +L + LRL + RG+P P + W N +P+ E
Sbjct: 4128 LPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTE 4171
Score = 57.4 bits (137), Expect = 4e-08
Identities = 49/193 (25%), Positives = 82/193 (42%), Gaps = 14/193 (7%)
Query: 229 ITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAEN 288
+TCN +G+P P + W+ G L + LTL + + D+G +C+A +
Sbjct: 1997 LTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV-LTLASARASDSG-RYSCVAVS 2054
Query: 289 VVGMSNASVALTVYYPPRVVSLEEPELRL----EHCIEFVVRGNPPPTLHWLHNGQPLRE 344
VG V L V+ PP ++ EE + + +E PPP L W +G+PL
Sbjct: 2055 AVGEDRQDVVLQVHMPPSILG-EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEP 2113
Query: 345 SKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEP-FPES 403
+H+ + L ++ ++ G+YT A N G + + N + P FP
Sbjct: 2114 RPGVHL------SADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLR 2167
Query: 404 TDNFILFDEVSPT 416
+ + E PT
Sbjct: 2168 ESHTLTVREGHPT 2180
Score = 55.1 bits (131), Expect = 2e-07
Identities = 60/236 (25%), Positives = 99/236 (41%), Gaps = 38/236 (16%)
Query: 179 EAKLNSQNLY-CI--NADGSQLPLFRMNISQCDLPEI-----SVSHVNLTVREGDNAVIT 230
+A L+S Y CI NA G + F++++ P I + +TV + +
Sbjct: 2505 QANLSSAGHYSCIAANAVGEKTKHFQLSVLLA--PTILGGAEDSADEEVTVTVNNPISLI 2562
Query: 231 CNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVV 290
C P P++ W+ G + L H L ++N ED G TC+ N +
Sbjct: 2563 CEALAFPSPNITWMKDGAPFEASRNIQL-LPGTHG--LQILNAQKEDAG-QYTCVVTNEL 2618
Query: 291 GMSNASVALTVYYPPRV--------VSLEEPELRLE-----HCIEFVVRGNPPPTLHWLH 337
G + + + V PP + V ++E + ++ C + V PPPT+ W
Sbjct: 2619 GEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAV---PPPTIRWYK 2675
Query: 338 NGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHY-NNGNYTLIAKNPLGTANQTIN 392
+GQP+ S + V + EG LL +PT ++G Y +A N G +Q N
Sbjct: 2676 DGQPVTPSSRLQV-------LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFN 2724
Score = 53.1 bits (126), Expect = 7e-07
Identities = 60/243 (24%), Positives = 101/243 (41%), Gaps = 26/243 (10%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
P I+ S NLT+ A++ C SGSP P V W G Q ++ + + N
Sbjct: 3764 PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDG-QKLD-FRLQQGAYRLLPSNAL 3821
Query: 270 LVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVV---- 325
L+ + C+ N VG ++ +TV+ PP + ++ + + V+
Sbjct: 3822 LLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIAD-DQTDFTVTMMAPVVLTCHS 3880
Query: 326 RGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLG 385
G P PT+ W G L ++ G + G L P H G YT A+N G
Sbjct: 3881 TGIPAPTVSWSKAGAQL-GARGSGYRVSPSGALEIGQAL---PIH--AGRYTCSARNSAG 3934
Query: 386 TANQ----TINGHFLKEPFPE-----STDNFILFDEVSPTPPITVTHKPEEDTFGVSIAV 436
A++ T+ + +P P + + +L E S P T+T + E G+++A
Sbjct: 3935 VAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKE----GLNVAT 3990
Query: 437 GLA 439
G++
Sbjct: 3991 GVS 3993
Score = 53.1 bits (126), Expect = 7e-07
Identities = 46/175 (26%), Positives = 73/175 (41%), Gaps = 22/175 (12%)
Query: 225 DNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTC 284
+ ++ C SG P P + W GL T + + L + + + ED G L C
Sbjct: 3963 EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQV----LPGGQLRIAHASPEDAGNYL-C 4017
Query: 285 IAENVVGMSNASVALTVYYPPRVVSLEEPELRLEH----CIEFVVRGNPPPTLHWLHNGQ 340
IA+N G + L V PP V+ P+L + RG+P P + W +GQ
Sbjct: 4018 IAKNSAGSAMGKTRLVVQVPP-VIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQ 4076
Query: 341 PLRESKIIHVEYYQEGEIS---EGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
P+ + EG+ + G LL + G YT A+N +G A + ++
Sbjct: 4077 PVSGA---------EGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVH 4122
Score = 50.8 bits (120), Expect = 4e-06
Identities = 52/241 (21%), Positives = 99/241 (41%), Gaps = 26/241 (10%)
Query: 178 GEAKLNSQNLY---CINADGSQLPLFRMNISQCDLPEISVSH---VNLTVREGDNAVITC 231
G+A+L + Y C N G+ ++ + P+I+ ++V + A + C
Sbjct: 2223 GQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVP--PQIAGPREPPTQVSVVQDGVATLEC 2280
Query: 232 NGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG 291
N +G P P V W G Q + + L N +L + + G +C+AEN+ G
Sbjct: 2281 NATGKPPPTVTWERDG-QPVGA-ELGLQLQN-QGQSLHVERAQAAHTG-RYSCVAENLAG 2336
Query: 292 MSNASVALTVYYPPRVVSLEEPELRLEHCIEFVV------RGNPPPTLHWLHNGQPLRES 345
+ L+V PP ++ +P + + + G PPP + W +P+
Sbjct: 2337 RAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPG 2396
Query: 346 KIIHVEYYQEGEISEGCLL-FNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPEST 404
+ ++ ++ G +L + ++G Y+ +A N G A + + L P E+
Sbjct: 2397 EDTYL-------LAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENE 2449
Query: 405 D 405
D
Sbjct: 2450 D 2450
Score = 50.4 bits (119), Expect = 5e-06
Identities = 48/194 (24%), Positives = 81/194 (41%), Gaps = 23/194 (11%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAIN-- 267
P+++ ++TV G +A++ C +G P P V W Q + + +
Sbjct: 786 PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG 845
Query: 268 -LTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV--YYPPRVVSLEEPELRLEH----- 319
L +V ED C A NV G A L V + PP++ S P +R+
Sbjct: 846 VLFFESVAPEDQA-PYVCEARNVFGKVQAEARLIVTGHAPPQIAS-SAPTVRVLEGQPVS 903
Query: 320 --CIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYT 377
CI V+ G P P HWL +G+PL + ++G L ++ + G Y+
Sbjct: 904 LPCI--VLAGRPLPERHWLKDGRPLPPGSRHSIR-------ADGSLHLDRALQEHAGRYS 954
Query: 378 LIAKNPLGTANQTI 391
+A N G+ ++ +
Sbjct: 955 CVATNTAGSQHRDV 968
Score = 50.4 bits (119), Expect = 5e-06
Identities = 44/194 (22%), Positives = 80/194 (41%), Gaps = 22/194 (11%)
Query: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLN 259
F++ + + E S L++ G + C+ G+P P++ W G Q++ + N
Sbjct: 3486 FQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG-QALTRLENNSR 3544
Query: 260 WTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRL-- 317
T V + D G TC+AE+ G S + V PP +V P +
Sbjct: 3545 ATRVLRVR---------DAGL-YTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGL 3594
Query: 318 ---EHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNG 374
+ +E V P P + W +G L+E H ++ + G L + ++G
Sbjct: 3595 APGQLVLECSVEAEPAPKITWHRDGIVLQED--AHTQFPERGRF----LQLQALSTADSG 3648
Query: 375 NYTLIAKNPLGTAN 388
+Y+ A+N G+ +
Sbjct: 3649 DYSCTARNAAGSTS 3662
Score = 49.3 bits (116), Expect = 1e-05
Identities = 45/186 (24%), Positives = 76/186 (40%), Gaps = 19/186 (10%)
Query: 210 PEISVSHVNLTVREGDNAVITCNG-SGSPLPDVDWIVTG--LQSINTHQTNLNWTNVHAI 266
P+I+ S + V EG + C +G PLP+ W+ G L + H ++ A
Sbjct: 885 PQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRH-------SIRAD 937
Query: 267 NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLE---HCIEF 323
++ +++ +C+A N G + V L V PPR+ + E +
Sbjct: 938 GSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPC 997
Query: 324 VVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNP 383
V G P PT+ W +E+ + EG LL +P+ + G Y A N
Sbjct: 998 VASGVPAPTITW------TKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNT 1051
Query: 384 LGTANQ 389
+G ++Q
Sbjct: 1052 VGFSSQ 1057
Score = 48.9 bits (115), Expect = 1e-05
Identities = 58/230 (25%), Positives = 89/230 (38%), Gaps = 37/230 (16%)
Query: 178 GEAKLNSQNLY---CINADGSQLPLFRMNISQCDL-------PEISVSHVNLTVREGDNA 227
G A+L+ +Y +NA G L ++++ P+ +V VR GD A
Sbjct: 2996 GRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAV-----LVRVGDKA 3050
Query: 228 VITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAE 287
V++C P P V W G + +T L + D G +C
Sbjct: 3051 VLSCETDALPEPTVTWYKDGQPLVLAQRTQ---ALRGGQRLEIQEAQVSDKGL-YSCKVS 3106
Query: 288 NVVGMSNASVALTVYYPPRVVSLEEPELRLEH-------CIEFVVRGNPPPTLHWLHNGQ 340
NV G + + LTV PP + E P+ + V G P PT+ WL +
Sbjct: 3107 NVAGEAVRTFTLTVQVPP---TFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRM 3163
Query: 341 PLRESKIIHVEYYQEGEISE-GCLLFNKPTHYNNGNYTLIAKNPLGTANQ 389
P+ ES +H G +S G L ++ G YT +A+N A +
Sbjct: 3164 PV-ESSAVH------GVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARK 3206
Score = 47.8 bits (112), Expect = 3e-05
Identities = 47/177 (26%), Positives = 73/177 (41%), Gaps = 18/177 (10%)
Query: 221 VREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGF 280
V EG + C G P PDV W+ G +L + + +L L + + D G
Sbjct: 3229 VLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY-LDGGSLVLKGLRASDAG- 3286
Query: 281 TLTCIAENVVGMSNASVALTVYYPPRVVSLEEPE----LRLEHCIEFV--VRGNPPPTLH 334
TC+A N G + V PP + + R + V VRG+PP +
Sbjct: 3287 AYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVS 3346
Query: 335 WLHNGQPLRESK--IIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQ 389
WL +G PL S+ ++H S L +K + G +T +A +P G A++
Sbjct: 3347 WLKDGLPLPLSQRTLLHG--------SGHTLRISKVQLADAGIFTCVAASPAGVADR 3395
Score = 47.8 bits (112), Expect = 3e-05
Identities = 29/97 (29%), Positives = 47/97 (48%), Gaps = 5/97 (5%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
P V ++TVR GD+ + C +G P P ++W LQ+ + + + +L
Sbjct: 4309 PVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEW----LQAGQPLRASRRLRTLPDGSLW 4364
Query: 270 LVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPR 306
L NV + D G T C+A N++G + A L V P+
Sbjct: 4365 LENVETGDAG-TYDCVAHNLLGSATARAFLVVRGEPQ 4400
Score = 47.0 bits (110), Expect = 5e-05
Identities = 60/245 (24%), Positives = 92/245 (37%), Gaps = 31/245 (12%)
Query: 208 DLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWI--VTGLQSINTHQTNLNWTNVHA 265
+ P++S+ + +G ++C+ SG P P + W LQ + + T
Sbjct: 606 EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT---- 661
Query: 266 INLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRL---EHCIE 322
L + V ED G +C A N VG +V L PP V ++ L E +
Sbjct: 662 --LIIQGVAPEDAG-NYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 718
Query: 323 FVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKN 382
G PPP + W G + + EG S G L + G YT A N
Sbjct: 719 CEASGVPPPRVIWYRGG--------LEMILAPEGS-SSGKLRIPAAQERDAGTYTCRAVN 769
Query: 383 PLGTANQTIN---GH------FLKEPFPESTDNFILFDEVSPTPPITVT-HKPEEDTFGV 432
LG A+ I GH ++ E + +L + PP TVT + + G+
Sbjct: 770 ELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL 829
Query: 433 SIAVG 437
+ G
Sbjct: 830 RLGAG 834
Score = 47.0 bits (110), Expect = 5e-05
Identities = 45/194 (23%), Positives = 80/194 (41%), Gaps = 25/194 (12%)
Query: 219 LTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDN 278
L R G+ + C GSP V W+ GL + +T L+ + H + ++ V + D
Sbjct: 3323 LVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSG-HTLRISKVQLA--DA 3379
Query: 279 GFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCI--------EFVVRGNPP 330
G TC+A + G+++ + L V PP LE E + + + RG P
Sbjct: 3380 GI-FTCVAASPAGVADRNFTLQVQVPP---VLEPVEFQNDVVVVRGSLVELPCEARGVPL 3435
Query: 331 PTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQT 390
P + W+ +G+PL + Q + G ++G Y+ +A + G A +
Sbjct: 3436 PLVSWMKDGEPLLSQSLEQGPSLQLEAVGAG----------DSGTYSCVAVSEAGEARRH 3485
Query: 391 INGHFLKEPFPEST 404
++ P E +
Sbjct: 3486 FQLTVMEPPHIEDS 3499
Score = 44.7 bits (104), Expect = 3e-04
Identities = 41/174 (23%), Positives = 72/174 (41%), Gaps = 17/174 (9%)
Query: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277
N+T + C G P P + W G + ++ + + +T T E
Sbjct: 2361 NITAALHSPLTLLCEAMGIPPPAIRWF-RGEEPVSPGEDTYLLAGGWMLKMTQ---TQEQ 2416
Query: 278 NGFTLTCIAENVVGMSNASVALTVYYPPRVVS--LEEPELRLEHCIEFV---VRGNPPPT 332
+ +C+A N G + + ++ V PP + + LEE L+ + V G+P P
Sbjct: 2417 DSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPK 2476
Query: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNN-GNYTLIAKNPLG 385
L W +G+PL H+ +G LL + ++ G+Y+ IA N +G
Sbjct: 2477 LTWFKDGRPLARGDAHHIS-------PDGVLLQVLQANLSSAGHYSCIAANAVG 2523
Score = 43.1 bits (100), Expect = 7e-04
Identities = 44/185 (23%), Positives = 74/185 (40%), Gaps = 40/185 (21%)
Query: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277
++ V G + C G PLP V W+ G + L+ + +L L V + D
Sbjct: 3415 DVVVVRGSLVELPCEARGVPLPLVSWMKDG-------EPLLSQSLEQGPSLQLEAVGAGD 3467
Query: 278 NGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEP-ELRLEHCIEFVV----RGNPPPT 332
+G T +C+A + G + LTV PP + +P EL L + +G P P
Sbjct: 3468 SG-TYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPN 3526
Query: 333 LHWLHNGQPL-------RESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLG 385
+ W +GQ L R ++++ V + G YT +A++P G
Sbjct: 3527 ITWHKDGQALTRLENNSRATRVLRVR--------------------DAGLYTCLAESPAG 3566
Query: 386 TANQT 390
++
Sbjct: 3567 AIEKS 3571
Score = 42.7 bits (99), Expect = 0.001
Identities = 41/174 (23%), Positives = 70/174 (40%), Gaps = 17/174 (9%)
Query: 223 EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
E + A + C+ + P PD+ W Q ++ + + LV +N
Sbjct: 2764 ENNPAYLYCDTNAIPPPDLTWYRED-QPLSAGDEVSVLQGGRVLQIPLVRA---ENAGRY 2819
Query: 283 TCIAENVVGMSNASVALTVYYPPRVVS-----LEEPELRLEHCIEFV--VRGNPPPTLHW 335
+C A N VG L V PP ++ +EE + + GNP PT+ W
Sbjct: 2820 SCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW 2879
Query: 336 LHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQ 389
L NG P S + V ++G++ L + + +Y +A+N G+A +
Sbjct: 2880 LQNGLPFSPSPRLQV--LEDGQV----LQVSTAEVADAASYMCVAENQAGSAEK 2927
Score = 42.4 bits (98), Expect = 0.001
Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 10/122 (8%)
Query: 268 LTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHC---IEFV 324
L + V D G TC A N+ G S VAL V PP + + LE+ +E +
Sbjct: 1850 LQIEKVDLRDEGI-YTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECL 1908
Query: 325 VRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPL 384
G PPP + W QP+ S + V +G + L + + G+Y +A N
Sbjct: 1909 ASGVPPPDVSWFKGHQPV--SSWMGVTVSVDGRV----LRIEQAQLSDAGSYRCVASNVA 1962
Query: 385 GT 386
G+
Sbjct: 1963 GS 1964
Score = 42.4 bits (98), Expect = 0.001
Identities = 28/128 (21%), Positives = 51/128 (39%), Gaps = 8/128 (6%)
Query: 219 LTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDN 278
+TV + C G+P+P + W+ GL + + + + + V+ +
Sbjct: 2855 VTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQV----LEDGQVLQVSTAEVAD 2910
Query: 279 GFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPE----LRLEHCIEFVVRGNPPPTLH 334
+ C+AEN G + L V PPR+ L+ + L + V +P P +
Sbjct: 2911 AASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT 2970
Query: 335 WLHNGQPL 342
W + Q L
Sbjct: 2971 WYKDSQAL 2978
Score = 41.6 bits (96), Expect = 0.002
Identities = 38/174 (21%), Positives = 70/174 (40%), Gaps = 17/174 (9%)
Query: 224 GDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLT 283
G + C G P P + W GL ++++ L ++ + E + +
Sbjct: 1611 GRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDG----SVLRLESPGEASSGLYS 1666
Query: 284 CIAENVVGMSNASVALTVYYPPRVVSLE---EPELRLEHCIEFVVR--GNPPPTLHWLHN 338
C+A + G + ++ V PP+++ E + + +E + G+P PT+ WL N
Sbjct: 1667 CVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQN 1726
Query: 339 GQPLRESKIIHVEYYQEGEISEGCLLFNKPTHY-NNGNYTLIAKNPLGTANQTI 391
G+P E + V S+G L ++G + A N GTA +
Sbjct: 1727 GRPAEELAGVQV-------ASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 1773
Score = 41.6 bits (96), Expect = 0.002
Identities = 49/224 (21%), Positives = 82/224 (36%), Gaps = 14/224 (6%)
Query: 169 RWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAV 228
R++QL Q A + NA GS FR+ I VN++V + A+
Sbjct: 3635 RFLQL-QALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQ--TAL 3691
Query: 229 ITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAEN 288
+ C G P P V W + + + + +L + V ++D G L C+A N
Sbjct: 3692 LPCQADGVPAPLVSW---RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL-CLASN 3747
Query: 289 VVGMSNASVALTVYYPPRVVSLEEPELRLEH---CIEFVVRGNPPPTLHWLHNGQPLRES 345
G L V PP + H + G+P P + W +GQ L
Sbjct: 3748 SAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLD-- 3805
Query: 346 KIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQ 389
++ + LL P ++ + + N +G A++
Sbjct: 3806 --FRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHR 3847
Score = 40.0 bits (92), Expect = 0.006
Identities = 60/246 (24%), Positives = 98/246 (39%), Gaps = 25/246 (10%)
Query: 109 TIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDI 168
TI+ +G R +A A P + TLSW + L + E N D
Sbjct: 1595 TIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWH-HEGLPVAE----SNESRLETDG 1649
Query: 169 RWMQLWQEQGEAKLNSQNLY-CINADGSQLPLFRMNISQCDLPEISVSHV--NLTVREGD 225
++L + GEA S LY C+ + + + + ++ P++ V+ +T G
Sbjct: 1650 SVLRL-ESPGEA---SSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQ 1705
Query: 226 NAVITCNGSGSPLPDVDWIVTG--LQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLT 283
+ C SGSP+P + W+ G + + Q T +H ++ L D+
Sbjct: 1706 PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVEL------DHSGLFA 1759
Query: 284 CIAENVVGMSNASVALTVY--YPPRV--VSLEEPELRLEHCIEFVVRGNPPPTLHW-LHN 338
C A N G + A V ++V+ + P V V + + EH F +PP W H
Sbjct: 1760 CQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHP 1819
Query: 339 GQPLRE 344
PL E
Sbjct: 1820 KPPLVE 1825
Score = 38.5 bits (88), Expect = 0.018
Identities = 40/186 (21%), Positives = 76/186 (40%), Gaps = 25/186 (13%)
Query: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINT------HQTNLNWTNV--HAI--- 266
N++ G + + C+ +G P+P++ W+ Q + + +L W V H +
Sbjct: 1309 NVSGMAGQSLTLECDANGFPVPEIVWL-KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDE 1367
Query: 267 --NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRL-----EH 319
+L + D+G +C AEN G + L V PP V+ + L +
Sbjct: 1368 GQSLHFPRIQEGDSGL-YSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADV 1426
Query: 320 CIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLI 379
++ G P P + W + QP+ H++ ++G++ L + G Y +
Sbjct: 1427 ELQCWTSGVPTPQVEWTKDRQPVLPGG-PHLQVQEDGQV----LRITGSHVGDEGRYQCV 1481
Query: 380 AKNPLG 385
A +P G
Sbjct: 1482 AFSPAG 1487
Score = 37.4 bits (85), Expect = 0.041
Identities = 36/125 (28%), Positives = 51/125 (40%), Gaps = 14/125 (11%)
Query: 224 GDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLT 283
G+NA + C G+P P V W G S H + +L L +V+ D+G
Sbjct: 1221 GENASLPCPARGTPKPQVTW-RKGPSSEPLH-GQPGVAVLEEGSLFLASVSPADSG-DYE 1277
Query: 284 CIAENVVGMSNASVALTVYYPPRVVSLEEPELRL--------EHCIEFVVRGNPPPTLHW 335
C A N VG ++ L VY PP S+ E + +E G P P + W
Sbjct: 1278 CQATNEVGSTSRRAKLVVYVPP---SIREDGRKANVSGMAGQSLTLECDANGFPVPEIVW 1334
Query: 336 LHNGQ 340
L + Q
Sbjct: 1335 LKDAQ 1339
Score = 34.3 bits (77), Expect = 0.34
Identities = 44/191 (23%), Positives = 70/191 (36%), Gaps = 22/191 (11%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
P I +N++V ++ + C P P + W G +L + +
Sbjct: 2071 PSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHL------SADKA 2124
Query: 270 LVNVTSED--NGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEH----CIEF 323
L+ V D + TC A N G S L V+ P E L + +
Sbjct: 2125 LLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSC 2184
Query: 324 VVRGNPPPTLHWLHNGQPL--RESKIIHVEYYQEGEISEGCLLF-NKPTHYNNGNYTLIA 380
RG P P + W +GQPL + + HV + G LL+ + G YT
Sbjct: 2185 ECRGVPFPKISWRKDGQPLPGEGAGLQHVS-------AVGRLLYLGQAQLAQEGTYTCEC 2237
Query: 381 KNPLGTANQTI 391
N +G ++Q +
Sbjct: 2238 SNVVGNSSQDL 2248
Score = 32.7 bits (73), Expect = 1.0
Identities = 42/187 (22%), Positives = 67/187 (35%), Gaps = 24/187 (12%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
P++ L V G+ + C G+P P + W G+ Q +VH
Sbjct: 1120 PQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGV----VLQGRGPQGSVH----- 1170
Query: 270 LVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPP-----RVVSLEEPELRLEHCIEFV 324
+ + D G C A N G+ V L V PP L E +
Sbjct: 1171 FAAIRTSDAG-RYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCP 1229
Query: 325 VRGNPPPTLHWLH--NGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKN 382
RG P P + W + +PL + V + EG L + ++G+Y A N
Sbjct: 1230 ARGTPKPQVTWRKGPSSEPLHGQPGVAV-------LEEGSLFLASVSPADSGDYECQATN 1282
Query: 383 PLGTANQ 389
+G+ ++
Sbjct: 1283 EVGSTSR 1289
Score = 31.2 bits (69), Expect = 2.9
Identities = 36/139 (25%), Positives = 50/139 (35%), Gaps = 22/139 (15%)
Query: 267 NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYP------PRVVSLEEPELRLEHC 320
+L L V D+G C A N G ++ L V P PRV+ + E +C
Sbjct: 1083 SLRLAQVQVGDSGH-YECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNC 1141
Query: 321 IEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIA 380
V GNP P L W +G L +G +G + F + G Y A
Sbjct: 1142 ---VAEGNPEPQLSWSKDGVVL------------QGRGPQGSVHFAAIRTSDAGRYRCEA 1186
Query: 381 KNPLGTANQTINGHFLKEP 399
N G + L+ P
Sbjct: 1187 SNSAGVDAWEVELRVLEPP 1205
Score = 29.6 bits (65), Expect = 8.5
Identities = 45/207 (21%), Positives = 68/207 (32%), Gaps = 36/207 (17%)
Query: 203 NISQCD-LPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWT 261
+IS+ D L E+ V V V + C P P + W G + + +
Sbjct: 2634 SISKDDPLGEVGVKEVKTKVNS--TLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGE 2691
Query: 262 NVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPP------------RVVS 309
L + T + C+A NV G + + + PP ++S
Sbjct: 2692 G----RLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILS 2747
Query: 310 LEEPELRLEHCIEFVVRGN-----------PPPTLHWLHNGQPLRESKIIHVEYYQEGEI 358
EE +V N PPP L W QPL V Q G +
Sbjct: 2748 REEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGD--EVSVLQGGRV 2805
Query: 359 SEGCLLFNKPTHYNNGNYTLIAKNPLG 385
+ L+ + N G Y+ A N +G
Sbjct: 2806 LQIPLVRAE----NAGRYSCKASNEVG 2828
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 68.2 bits (165), Expect = 2e-11
Identities = 56/216 (25%), Positives = 89/216 (41%), Gaps = 15/216 (6%)
Query: 190 INADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQ 249
+N G + +N+ + + SH LTVREG ++C G P P + W G Q
Sbjct: 862 LNQAGHSEKHYNLNVWVAPVFPLRESHT-LTVREGHPTRLSCECRGVPFPKISWRKDG-Q 919
Query: 250 SINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVS 309
+ L + L L G T TC NVVG S+ + L V+ PP++
Sbjct: 920 PLPGEGAGLQHVSAVGRLLYLGQAQLAQEG-TYTCECSNVVGNSSQDLQLEVHVPPQIAG 978
Query: 310 LEEPELRLE------HCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCL 363
EP ++ +E G PPPT+ W +GQP+ + ++ +G+ L
Sbjct: 979 PREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAE--LGLQLQNQGQ----SL 1032
Query: 364 LFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEP 399
+ + G Y+ +A+N G A + L P
Sbjct: 1033 HVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPP 1068
Score = 65.5 bits (158), Expect = 1e-10
Identities = 53/196 (27%), Positives = 90/196 (45%), Gaps = 19/196 (9%)
Query: 201 RMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNW 260
R++++ LP + + ++R GD + C GSP P + W V + + + +
Sbjct: 2838 RVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVND-RPVTEGVSEQDG 2896
Query: 261 TNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHC 320
+ L V+ ED+G T C AEN VG + A + V P V+ E +E
Sbjct: 2897 GST----LQRAAVSREDSG-TYVCWAENRVGRTQAVSFVHVKEAP-VLQGEAFSYLVEPV 2950
Query: 321 -----IEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGN 375
++ VVRG+P P +HW+ +G PLR S + H ++ G L + + G
Sbjct: 2951 GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRH-------QLQNGSLTIRRTERDDAGR 3003
Query: 376 YTLIAKNPLGTANQTI 391
Y +A+N +G A + +
Sbjct: 3004 YQCLAENEMGVAKKVV 3019
Score = 65.1 bits (157), Expect = 2e-10
Identities = 61/226 (26%), Positives = 95/226 (42%), Gaps = 39/226 (17%)
Query: 179 EAKLNSQNLYCI---NADGSQLPLFRMNISQCDLPEISVSHVNLTVRE--GDNAVITCNG 233
EA+++ + LY N G + F + + +P + TV + G V+TC+
Sbjct: 1810 EAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ---VPPTFENPKTETVSQVAGSPLVLTCDV 1866
Query: 234 SGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAI-----NLTLVNVTSEDNGFTLTCIAEN 288
SG P P V W+ + + + VH + L L + G T TC+AEN
Sbjct: 1867 SGVPAPTVTWLKDRMP--------VESSAVHGVVSRGGRLQLSRLQPAQAG-TYTCVAEN 1917
Query: 289 VVGMSNASVALTVYYPPRVVS---------LEEPELRLEHCIEFVVRGNPPPTLHWLHNG 339
+ + V PR+ S LE E+RL+ + G PPP + WL +G
Sbjct: 1918 TQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEAD----GQPPPDVAWLKDG 1973
Query: 340 QPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLG 385
PL + H+ +Y +G G L+ + G YT +A NP G
Sbjct: 1974 SPLGQDMGPHLRFYLDG----GSLVLKGLRASDAGAYTCVAHNPAG 2015
Score = 64.3 bits (155), Expect = 3e-10
Identities = 50/175 (28%), Positives = 74/175 (42%), Gaps = 16/175 (9%)
Query: 219 LTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDN 278
+ V E + C G P P++ W G ++ T + +T L L S D
Sbjct: 230 VAVMEDHLVQLLCEARGVPTPNITWFKDG--ALLPTSTKVVYTR-GGRQLQLGRAQSSDA 286
Query: 279 GFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEH------CIEFVVRGNPPPT 332
G TC A N VG + + L VY PP + ++ +E V RG+P PT
Sbjct: 287 G-VYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPT 345
Query: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTA 387
L W H G P+ ES +E +G + L P ++G Y+ +A +P G A
Sbjct: 346 LSWHHEGLPVAESNESRLE--TDGSV----LRLESPGEASSGLYSCVASSPAGEA 394
Score = 64.3 bits (155), Expect = 3e-10
Identities = 47/168 (27%), Positives = 76/168 (45%), Gaps = 17/168 (10%)
Query: 224 GDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLT 283
G + + C G P+PD+ WI GL +H + + +LT+ +D G
Sbjct: 2951 GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRH----QLQNGSLTIRRTERDDAG-RYQ 3005
Query: 284 CIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPTLHWLHNG 339
C+AEN +G++ V L + P V +E ++ + + +R G P PT+ WL G
Sbjct: 3006 CLAENEMGVAKKVVILVLQSAP-VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAG 3064
Query: 340 QPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTA 387
QPLR S+ + + +G L + G Y +A N LG+A
Sbjct: 3065 QPLRASRRLRT-------LPDGSLWLENVETGDAGTYDCVAHNLLGSA 3105
Score = 59.7 bits (143), Expect = 8e-09
Identities = 51/190 (26%), Positives = 75/190 (39%), Gaps = 20/190 (10%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNW----TNVHA 265
P I VN V E + + C SG P PDV W HQ +W +V
Sbjct: 604 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSW-------FKGHQPVSSWMGVTVSVDG 656
Query: 266 INLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVV---SLEEPEL-RLEHCI 321
L + D G + C+A NV G + L V PPR+ SL P L +
Sbjct: 657 RVLRIEQAQLSDAG-SYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRL 715
Query: 322 EFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAK 381
G P PTL WL +G P+ + ++ + G + L ++G Y+ +A
Sbjct: 716 TCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV----LTLASARASDSGRYSCVAV 771
Query: 382 NPLGTANQTI 391
+ +G Q +
Sbjct: 772 SAVGEDRQDV 781
Score = 58.2 bits (139), Expect = 2e-08
Identities = 50/164 (30%), Positives = 77/164 (46%), Gaps = 11/164 (6%)
Query: 186 NLYCI--NADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
N CI N+ GS + R+ + P I +L+ EG +A + C GSP P++ W
Sbjct: 2732 NYLCIAKNSAGSAMGKTRLVVQVP--PVIENGLPDLSTTEGSHAFLPCKARGSPEPNITW 2789
Query: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
G Q ++ + +T + L + N+ +D G T TC AEN VG + V LT+
Sbjct: 2790 DKDG-QPVSGAEG--KFTIQPSGELLVKNLEGQDAG-TYTCTAENAVGRARRRVHLTILV 2845
Query: 304 PPRVVSLE-EPELRL--EHCIEFVVRGNPPPTLHWLHNGQPLRE 344
P +L + LRL + RG+P P + W N +P+ E
Sbjct: 2846 LPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTE 2889
Score = 57.4 bits (137), Expect = 4e-08
Identities = 49/193 (25%), Positives = 82/193 (42%), Gaps = 14/193 (7%)
Query: 229 ITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAEN 288
+TCN +G+P P + W+ G L + LTL + + D+G +C+A +
Sbjct: 715 LTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV-LTLASARASDSG-RYSCVAVS 772
Query: 289 VVGMSNASVALTVYYPPRVVSLEEPELRL----EHCIEFVVRGNPPPTLHWLHNGQPLRE 344
VG V L V+ PP ++ EE + + +E PPP L W +G+PL
Sbjct: 773 AVGEDRQDVVLQVHMPPSILG-EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEP 831
Query: 345 SKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEP-FPES 403
+H+ + L ++ ++ G+YT A N G + + N + P FP
Sbjct: 832 RPGVHL------SADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLR 885
Query: 404 TDNFILFDEVSPT 416
+ + E PT
Sbjct: 886 ESHTLTVREGHPT 898
Score = 55.1 bits (131), Expect = 2e-07
Identities = 60/236 (25%), Positives = 99/236 (41%), Gaps = 38/236 (16%)
Query: 179 EAKLNSQNLY-CI--NADGSQLPLFRMNISQCDLPEI-----SVSHVNLTVREGDNAVIT 230
+A L+S Y CI NA G + F++++ P I + +TV + +
Sbjct: 1223 QANLSSAGHYSCIAANAVGEKTKHFQLSVLLA--PTILGGAEDSADEEVTVTVNNPISLI 1280
Query: 231 CNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVV 290
C P P++ W+ G + L H L ++N ED G TC+ N +
Sbjct: 1281 CEALAFPSPNITWMKDGAPFEASRNIQL-LPGTHG--LQILNAQKEDAG-QYTCVVTNEL 1336
Query: 291 GMSNASVALTVYYPPRV--------VSLEEPELRLE-----HCIEFVVRGNPPPTLHWLH 337
G + + + V PP + V ++E + ++ C + V PPPT+ W
Sbjct: 1337 GEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAV---PPPTIRWYK 1393
Query: 338 NGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHY-NNGNYTLIAKNPLGTANQTIN 392
+GQP+ S + V + EG LL +PT ++G Y +A N G +Q N
Sbjct: 1394 DGQPVTPSSRLQV-------LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFN 1442
Score = 53.1 bits (126), Expect = 7e-07
Identities = 60/243 (24%), Positives = 101/243 (41%), Gaps = 26/243 (10%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
P I+ S NLT+ A++ C SGSP P V W G Q ++ + + N
Sbjct: 2482 PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDG-QKLD-FRLQQGAYRLLPSNAL 2539
Query: 270 LVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVV---- 325
L+ + C+ N VG ++ +TV+ PP + ++ + + V+
Sbjct: 2540 LLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIAD-DQTDFTVTMMAPVVLTCHS 2598
Query: 326 RGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLG 385
G P PT+ W G L ++ G + G L P H G YT A+N G
Sbjct: 2599 TGIPAPTVSWSKAGAQL-GARGSGYRVSPSGALEIGQAL---PIH--AGRYTCSARNSAG 2652
Query: 386 TANQ----TINGHFLKEPFPE-----STDNFILFDEVSPTPPITVTHKPEEDTFGVSIAV 436
A++ T+ + +P P + + +L E S P T+T + E G+++A
Sbjct: 2653 VAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKE----GLNVAT 2708
Query: 437 GLA 439
G++
Sbjct: 2709 GVS 2711
Score = 53.1 bits (126), Expect = 7e-07
Identities = 46/175 (26%), Positives = 73/175 (41%), Gaps = 22/175 (12%)
Query: 225 DNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTC 284
+ ++ C SG P P + W GL T + + L + + + ED G L C
Sbjct: 2681 EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQV----LPGGQLRIAHASPEDAGNYL-C 2735
Query: 285 IAENVVGMSNASVALTVYYPPRVVSLEEPELRLEH----CIEFVVRGNPPPTLHWLHNGQ 340
IA+N G + L V PP V+ P+L + RG+P P + W +GQ
Sbjct: 2736 IAKNSAGSAMGKTRLVVQVPP-VIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQ 2794
Query: 341 PLRESKIIHVEYYQEGEIS---EGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
P+ + EG+ + G LL + G YT A+N +G A + ++
Sbjct: 2795 PVSGA---------EGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVH 2840
Score = 50.8 bits (120), Expect = 4e-06
Identities = 52/241 (21%), Positives = 99/241 (41%), Gaps = 26/241 (10%)
Query: 178 GEAKLNSQNLY---CINADGSQLPLFRMNISQCDLPEISVSH---VNLTVREGDNAVITC 231
G+A+L + Y C N G+ ++ + P+I+ ++V + A + C
Sbjct: 941 GQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVP--PQIAGPREPPTQVSVVQDGVATLEC 998
Query: 232 NGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG 291
N +G P P V W G Q + + L N +L + + G +C+AEN+ G
Sbjct: 999 NATGKPPPTVTWERDG-QPVGA-ELGLQLQN-QGQSLHVERAQAAHTG-RYSCVAENLAG 1054
Query: 292 MSNASVALTVYYPPRVVSLEEPELRLEHCIEFVV------RGNPPPTLHWLHNGQPLRES 345
+ L+V PP ++ +P + + + G PPP + W +P+
Sbjct: 1055 RAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPG 1114
Query: 346 KIIHVEYYQEGEISEGCLL-FNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPEST 404
+ ++ ++ G +L + ++G Y+ +A N G A + + L P E+
Sbjct: 1115 EDTYL-------LAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENE 1167
Query: 405 D 405
D
Sbjct: 1168 D 1168
Score = 50.4 bits (119), Expect = 5e-06
Identities = 44/194 (22%), Positives = 80/194 (41%), Gaps = 22/194 (11%)
Query: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLN 259
F++ + + E S L++ G + C+ G+P P++ W G Q++ + N
Sbjct: 2204 FQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG-QALTRLENNSR 2262
Query: 260 WTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRL-- 317
T V + D G TC+AE+ G S + V PP +V P +
Sbjct: 2263 ATRVLRVR---------DAGL-YTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGL 2312
Query: 318 ---EHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNG 374
+ +E V P P + W +G L+E H ++ + G L + ++G
Sbjct: 2313 APGQLVLECSVEAEPAPKITWHRDGIVLQED--AHTQFPERGRF----LQLQALSTADSG 2366
Query: 375 NYTLIAKNPLGTAN 388
+Y+ A+N G+ +
Sbjct: 2367 DYSCTARNAAGSTS 2380
Score = 48.9 bits (115), Expect = 1e-05
Identities = 58/230 (25%), Positives = 89/230 (38%), Gaps = 37/230 (16%)
Query: 178 GEAKLNSQNLY---CINADGSQLPLFRMNISQCDL-------PEISVSHVNLTVREGDNA 227
G A+L+ +Y +NA G L ++++ P+ +V VR GD A
Sbjct: 1714 GRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAV-----LVRVGDKA 1768
Query: 228 VITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAE 287
V++C P P V W G + +T L + D G +C
Sbjct: 1769 VLSCETDALPEPTVTWYKDGQPLVLAQRTQ---ALRGGQRLEIQEAQVSDKGL-YSCKVS 1824
Query: 288 NVVGMSNASVALTVYYPPRVVSLEEPELRLEH-------CIEFVVRGNPPPTLHWLHNGQ 340
NV G + + LTV PP + E P+ + V G P PT+ WL +
Sbjct: 1825 NVAGEAVRTFTLTVQVPP---TFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRM 1881
Query: 341 PLRESKIIHVEYYQEGEISE-GCLLFNKPTHYNNGNYTLIAKNPLGTANQ 389
P+ ES +H G +S G L ++ G YT +A+N A +
Sbjct: 1882 PV-ESSAVH------GVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARK 1924
Score = 47.8 bits (112), Expect = 3e-05
Identities = 47/177 (26%), Positives = 73/177 (41%), Gaps = 18/177 (10%)
Query: 221 VREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGF 280
V EG + C G P PDV W+ G +L + + +L L + + D G
Sbjct: 1947 VLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY-LDGGSLVLKGLRASDAG- 2004
Query: 281 TLTCIAENVVGMSNASVALTVYYPPRVVSLEEPE----LRLEHCIEFV--VRGNPPPTLH 334
TC+A N G + V PP + + R + V VRG+PP +
Sbjct: 2005 AYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVS 2064
Query: 335 WLHNGQPLRESK--IIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQ 389
WL +G PL S+ ++H S L +K + G +T +A +P G A++
Sbjct: 2065 WLKDGLPLPLSQRTLLHG--------SGHTLRISKVQLADAGIFTCVAASPAGVADR 2113
Score = 47.8 bits (112), Expect = 3e-05
Identities = 29/97 (29%), Positives = 47/97 (48%), Gaps = 5/97 (5%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
P V ++TVR GD+ + C +G P P ++W LQ+ + + + +L
Sbjct: 3027 PVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEW----LQAGQPLRASRRLRTLPDGSLW 3082
Query: 270 LVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPR 306
L NV + D G T C+A N++G + A L V P+
Sbjct: 3083 LENVETGDAG-TYDCVAHNLLGSATARAFLVVRGEPQ 3118
Score = 47.0 bits (110), Expect = 5e-05
Identities = 45/194 (23%), Positives = 80/194 (41%), Gaps = 25/194 (12%)
Query: 219 LTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDN 278
L R G+ + C GSP V W+ GL + +T L+ + H + ++ V + D
Sbjct: 2041 LVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSG-HTLRISKVQLA--DA 2097
Query: 279 GFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCI--------EFVVRGNPP 330
G TC+A + G+++ + L V PP LE E + + + RG P
Sbjct: 2098 GI-FTCVAASPAGVADRNFTLQVQVPP---VLEPVEFQNDVVVVRGSLVELPCEARGVPL 2153
Query: 331 PTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQT 390
P + W+ +G+PL + Q + G ++G Y+ +A + G A +
Sbjct: 2154 PLVSWMKDGEPLLSQSLEQGPSLQLEAVGAG----------DSGTYSCVAVSEAGEARRH 2203
Query: 391 INGHFLKEPFPEST 404
++ P E +
Sbjct: 2204 FQLTVMEPPHIEDS 2217
Score = 44.7 bits (104), Expect = 3e-04
Identities = 41/174 (23%), Positives = 72/174 (41%), Gaps = 17/174 (9%)
Query: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277
N+T + C G P P + W G + ++ + + +T T E
Sbjct: 1079 NITAALHSPLTLLCEAMGIPPPAIRWF-RGEEPVSPGEDTYLLAGGWMLKMTQ---TQEQ 1134
Query: 278 NGFTLTCIAENVVGMSNASVALTVYYPPRVVS--LEEPELRLEHCIEFV---VRGNPPPT 332
+ +C+A N G + + ++ V PP + + LEE L+ + V G+P P
Sbjct: 1135 DSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPK 1194
Query: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNN-GNYTLIAKNPLG 385
L W +G+PL H+ +G LL + ++ G+Y+ IA N +G
Sbjct: 1195 LTWFKDGRPLARGDAHHIS-------PDGVLLQVLQANLSSAGHYSCIAANAVG 1241
Score = 43.1 bits (100), Expect = 7e-04
Identities = 44/185 (23%), Positives = 74/185 (40%), Gaps = 40/185 (21%)
Query: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277
++ V G + C G PLP V W+ G + L+ + +L L V + D
Sbjct: 2133 DVVVVRGSLVELPCEARGVPLPLVSWMKDG-------EPLLSQSLEQGPSLQLEAVGAGD 2185
Query: 278 NGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEP-ELRLEHCIEFVV----RGNPPPT 332
+G T +C+A + G + LTV PP + +P EL L + +G P P
Sbjct: 2186 SG-TYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPN 2244
Query: 333 LHWLHNGQPL-------RESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLG 385
+ W +GQ L R ++++ V + G YT +A++P G
Sbjct: 2245 ITWHKDGQALTRLENNSRATRVLRVR--------------------DAGLYTCLAESPAG 2284
Query: 386 TANQT 390
++
Sbjct: 2285 AIEKS 2289
Score = 42.7 bits (99), Expect = 0.001
Identities = 41/174 (23%), Positives = 70/174 (40%), Gaps = 17/174 (9%)
Query: 223 EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
E + A + C+ + P PD+ W Q ++ + + LV +N
Sbjct: 1482 ENNPAYLYCDTNAIPPPDLTWYRED-QPLSAGDEVSVLQGGRVLQIPLVRA---ENAGRY 1537
Query: 283 TCIAENVVGMSNASVALTVYYPPRVVS-----LEEPELRLEHCIEFV--VRGNPPPTLHW 335
+C A N VG L V PP ++ +EE + + GNP PT+ W
Sbjct: 1538 SCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW 1597
Query: 336 LHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQ 389
L NG P S + V ++G++ L + + +Y +A+N G+A +
Sbjct: 1598 LQNGLPFSPSPRLQV--LEDGQV----LQVSTAEVADAASYMCVAENQAGSAEK 1645
Score = 42.4 bits (98), Expect = 0.001
Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 10/122 (8%)
Query: 268 LTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHC---IEFV 324
L + V D G TC A N+ G S VAL V PP + + LE+ +E +
Sbjct: 568 LQIEKVDLRDEGI-YTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECL 626
Query: 325 VRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPL 384
G PPP + W QP+ S + V +G + L + + G+Y +A N
Sbjct: 627 ASGVPPPDVSWFKGHQPV--SSWMGVTVSVDGRV----LRIEQAQLSDAGSYRCVASNVA 680
Query: 385 GT 386
G+
Sbjct: 681 GS 682
Score = 42.4 bits (98), Expect = 0.001
Identities = 28/128 (21%), Positives = 51/128 (39%), Gaps = 8/128 (6%)
Query: 219 LTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDN 278
+TV + C G+P+P + W+ GL + + + + + V+ +
Sbjct: 1573 VTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQV----LEDGQVLQVSTAEVAD 1628
Query: 279 GFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPE----LRLEHCIEFVVRGNPPPTLH 334
+ C+AEN G + L V PPR+ L+ + L + V +P P +
Sbjct: 1629 AASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT 1688
Query: 335 WLHNGQPL 342
W + Q L
Sbjct: 1689 WYKDSQAL 1696
Score = 41.6 bits (96), Expect = 0.002
Identities = 38/174 (21%), Positives = 70/174 (40%), Gaps = 17/174 (9%)
Query: 224 GDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLT 283
G + C G P P + W GL ++++ L ++ + E + +
Sbjct: 329 GRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDG----SVLRLESPGEASSGLYS 384
Query: 284 CIAENVVGMSNASVALTVYYPPRVVSLE---EPELRLEHCIEFVVR--GNPPPTLHWLHN 338
C+A + G + ++ V PP+++ E + + +E + G+P PT+ WL N
Sbjct: 385 CVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQN 444
Query: 339 GQPLRESKIIHVEYYQEGEISEGCLLFNKPTHY-NNGNYTLIAKNPLGTANQTI 391
G+P E + V S+G L ++G + A N GTA +
Sbjct: 445 GRPAEELAGVQV-------ASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 491
Score = 41.6 bits (96), Expect = 0.002
Identities = 49/224 (21%), Positives = 82/224 (36%), Gaps = 14/224 (6%)
Query: 169 RWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAV 228
R++QL Q A + NA GS FR+ I VN++V + A+
Sbjct: 2353 RFLQL-QALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQ--TAL 2409
Query: 229 ITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAEN 288
+ C G P P V W + + + + +L + V ++D G L C+A N
Sbjct: 2410 LPCQADGVPAPLVSW---RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL-CLASN 2465
Query: 289 VVGMSNASVALTVYYPPRVVSLEEPELRLEH---CIEFVVRGNPPPTLHWLHNGQPLRES 345
G L V PP + H + G+P P + W +GQ L
Sbjct: 2466 SAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLD-- 2523
Query: 346 KIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQ 389
++ + LL P ++ + + N +G A++
Sbjct: 2524 --FRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHR 2565
Score = 40.0 bits (92), Expect = 0.006
Identities = 60/246 (24%), Positives = 98/246 (39%), Gaps = 25/246 (10%)
Query: 109 TIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDI 168
TI+ +G R +A A P + TLSW + L + E N D
Sbjct: 313 TIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWH-HEGLPVAE----SNESRLETDG 367
Query: 169 RWMQLWQEQGEAKLNSQNLY-CINADGSQLPLFRMNISQCDLPEISVSHV--NLTVREGD 225
++L + GEA S LY C+ + + + + ++ P++ V+ +T G
Sbjct: 368 SVLRL-ESPGEA---SSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQ 423
Query: 226 NAVITCNGSGSPLPDVDWIVTG--LQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLT 283
+ C SGSP+P + W+ G + + Q T +H ++ L D+
Sbjct: 424 PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVEL------DHSGLFA 477
Query: 284 CIAENVVGMSNASVALTVY--YPPRV--VSLEEPELRLEHCIEFVVRGNPPPTLHW-LHN 338
C A N G + A V ++V+ + P V V + + EH F +PP W H
Sbjct: 478 CQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHP 537
Query: 339 GQPLRE 344
PL E
Sbjct: 538 KPPLVE 543
Score = 38.5 bits (88), Expect = 0.018
Identities = 40/186 (21%), Positives = 76/186 (40%), Gaps = 25/186 (13%)
Query: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINT------HQTNLNWTNV--HAI--- 266
N++ G + + C+ +G P+P++ W+ Q + + +L W V H +
Sbjct: 27 NVSGMAGQSLTLECDANGFPVPEIVWL-KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDE 85
Query: 267 --NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRL-----EH 319
+L + D+G +C AEN G + L V PP V+ + L +
Sbjct: 86 GQSLHFPRIQEGDSGL-YSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADV 144
Query: 320 CIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLI 379
++ G P P + W + QP+ H++ ++G++ L + G Y +
Sbjct: 145 ELQCWTSGVPTPQVEWTKDRQPVLPGG-PHLQVQEDGQV----LRITGSHVGDEGRYQCV 199
Query: 380 AKNPLG 385
A +P G
Sbjct: 200 AFSPAG 205
Score = 33.5 bits (75), Expect = 0.59
Identities = 44/191 (23%), Positives = 70/191 (36%), Gaps = 22/191 (11%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
P I +N++V ++ + C P P + W G +L + +
Sbjct: 789 PSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHL------SADKA 842
Query: 270 LVNVTSED--NGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEH----CIEF 323
L+ V D + TC A N G S L V+ P E L + +
Sbjct: 843 LLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSC 902
Query: 324 VVRGNPPPTLHWLHNGQPL--RESKIIHVEYYQEGEISEGCLLF-NKPTHYNNGNYTLIA 380
RG P P + W +GQPL + + HV + G LL+ + G YT
Sbjct: 903 ECRGVPFPKISWRKDGQPLPGEGAGLQHVS-------AVGRLLYLGQAQLAQEGTYTCEC 955
Query: 381 KNPLGTANQTI 391
N +G ++Q +
Sbjct: 956 SNVVGNSSQDL 966
Score = 30.0 bits (66), Expect = 6.5
Identities = 45/207 (21%), Positives = 68/207 (32%), Gaps = 36/207 (17%)
Query: 203 NISQCD-LPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWT 261
+IS+ D L E+ V V V + C P P + W G + + +
Sbjct: 1352 SISKDDPLAEVGVKEVKTKVNS--TLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGE 1409
Query: 262 NVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPP------------RVVS 309
L + T + C+A NV G + + + PP ++S
Sbjct: 1410 G----RLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILS 1465
Query: 310 LEEPELRLEHCIEFVVRGN-----------PPPTLHWLHNGQPLRESKIIHVEYYQEGEI 358
EE +V N PPP L W QPL V Q G +
Sbjct: 1466 REEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGD--EVSVLQGGRV 1523
Query: 359 SEGCLLFNKPTHYNNGNYTLIAKNPLG 385
+ L+ + N G Y+ A N +G
Sbjct: 1524 LQIPLVRAE----NAGRYSCKASNEVG 1546
>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
Length = 513
Score = 67.8 bits (164), Expect = 3e-11
Identities = 44/146 (30%), Positives = 78/146 (53%), Gaps = 7/146 (4%)
Query: 105 LQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTL-SLRELQLEQNFFN 163
LQ+L ++ + + ++ +A A L ++LS N+L T+S + Q L SL+ L+L +N +
Sbjct: 148 LQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLTENPWR 207
Query: 164 CSCDIRWMQLW-QEQGEAKLNSQNLYCINADGSQLPL-FRMNISQ----CDLPEISVSHV 217
C C + W+ W +E G+ L S++ + A+ +L L +++S C P + V +
Sbjct: 208 CDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLICIPPSVHVQPL 267
Query: 218 NLTVREGDNAVITCNGSGSPLPDVDW 243
LT G++ + C SG P P V W
Sbjct: 268 ELTANLGEDLRVACQASGYPQPLVTW 293
Score = 33.1 bits (74), Expect = 0.77
Identities = 24/70 (34%), Positives = 36/70 (51%), Gaps = 1/70 (1%)
Query: 105 LQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLS-LRELQLEQNFFN 163
L++L + N+ LR+++ AF P L + L+SNRL L F L+ LR L L N
Sbjct: 76 LRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLA 135
Query: 164 CSCDIRWMQL 173
D ++ L
Sbjct: 136 RLLDFTFLHL 145
>gi|41582239 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
Length = 428
Score = 67.4 bits (163), Expect = 4e-11
Identities = 68/255 (26%), Positives = 112/255 (43%), Gaps = 36/255 (14%)
Query: 75 DISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINL 134
D+S N+ S W LH L+A LQ L + ++ L I AF LR + L
Sbjct: 104 DLSHNLISDFA--WSDLHNLSA--------LQLLKMDSNELTFIPRDAFRSLRALRSLQL 153
Query: 135 SSNRLTTLSWQLFQTLS-LRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQ-NLYCINA 192
+ NRL TL+ F L+ L LQ+ +N F+C+C I W++ W + Q N+ C +
Sbjct: 154 NHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSP 213
Query: 193 DGSQ-LPLFRMNISQCDLPEISVSHV----NLTVREGDNAVITCNGSGSPLPDVDW---I 244
+ PL R+ C P + +S+ +R G + C+ G P P + W I
Sbjct: 214 HVLKGTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQI 273
Query: 245 VTGL-----QSINTHQTNLNWTNVHAI----------NLTLVNVTSEDNGFTLTCIAENV 289
+G+ ++ T L T V + +L + + + G T +C+A N
Sbjct: 274 PSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEG-TYSCLATNE 332
Query: 290 VGMSNASVALTVYYP 304
+G + +SV + + P
Sbjct: 333 LGSAESSVDVALATP 347
>gi|5031809 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
Length = 428
Score = 67.4 bits (163), Expect = 4e-11
Identities = 68/255 (26%), Positives = 112/255 (43%), Gaps = 36/255 (14%)
Query: 75 DISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINL 134
D+S N+ S W LH L+A LQ L + ++ L I AF LR + L
Sbjct: 104 DLSHNLISDFA--WSDLHNLSA--------LQLLKMDSNELTFIPRDAFRSLRALRSLQL 153
Query: 135 SSNRLTTLSWQLFQTLS-LRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQ-NLYCINA 192
+ NRL TL+ F L+ L LQ+ +N F+C+C I W++ W + Q N+ C +
Sbjct: 154 NHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSP 213
Query: 193 DGSQ-LPLFRMNISQCDLPEISVSHV----NLTVREGDNAVITCNGSGSPLPDVDW---I 244
+ PL R+ C P + +S+ +R G + C+ G P P + W I
Sbjct: 214 HVLKGTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQI 273
Query: 245 VTGL-----QSINTHQTNLNWTNVHAI----------NLTLVNVTSEDNGFTLTCIAENV 289
+G+ ++ T L T V + +L + + + G T +C+A N
Sbjct: 274 PSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEG-TYSCLATNE 332
Query: 290 VGMSNASVALTVYYP 304
+G + +SV + + P
Sbjct: 333 LGSAESSVDVALATP 347
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,560,136
Number of Sequences: 37866
Number of extensions: 1280735
Number of successful extensions: 5306
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 219
Number of HSP's successfully gapped in prelim test: 199
Number of HSP's that attempted gapping in prelim test: 2659
Number of HSP's gapped (non-prelim): 1963
length of query: 612
length of database: 18,247,518
effective HSP length: 108
effective length of query: 504
effective length of database: 14,157,990
effective search space: 7135626960
effective search space used: 7135626960
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.