Guide to the Human Genome
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Search of human proteins with 55743149

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
         (1298 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]             2681   0.0  
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]             2681   0.0  
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]         124   8e-28
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]         124   8e-28
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]         124   8e-28
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]           124   8e-28
gi|19913367 transducin beta-like 1Y [Homo sapiens]                    124   8e-28
gi|19913365 transducin beta-like 1Y [Homo sapiens]                    124   8e-28
gi|15150805 transducin beta-like 1Y [Homo sapiens]                    124   8e-28
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...   120   6e-27
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...   107   1e-22
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...   107   1e-22
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...   107   1e-22
gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]             100   1e-20
gi|32189425 WD repeat domain 69 [Homo sapiens]                         96   2e-19
gi|157739942 gemin 5 [Homo sapiens]                                    95   4e-19
gi|4502477 beta-transducin repeat containing protein isoform 2 [...    90   2e-17
gi|16117783 beta-transducin repeat containing protein isoform 1 ...    90   2e-17
gi|48928050 F-box and WD repeat domain containing 11 isoform C [...    88   6e-17
gi|48928048 F-box and WD repeat domain containing 11 isoform A [...    88   6e-17
gi|48928046 F-box and WD repeat domain containing 11 isoform B [...    88   6e-17
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...    87   8e-17
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...    87   1e-16
gi|16554629 WD repeat domain 5 [Homo sapiens]                          86   2e-16
gi|16554627 WD repeat domain 5 [Homo sapiens]                          86   2e-16
gi|23199987 WD repeat domain 5B [Homo sapiens]                         84   9e-16
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     82   3e-15
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            81   6e-15
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     80   2e-14
gi|118402582 cell division cycle 20 [Homo sapiens]                     79   2e-14

>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
          Length = 1298

 Score = 2681 bits (6950), Expect = 0.0
 Identities = 1298/1298 (100%), Positives = 1298/1298 (100%)

Query: 1    MSQVRQVGLLAAGCQPWNKDVCAASGDRFAYCATLAIYIYQLDHRYNEFKLHAIMSEHKK 60
            MSQVRQVGLLAAGCQPWNKDVCAASGDRFAYCATLAIYIYQLDHRYNEFKLHAIMSEHKK
Sbjct: 1    MSQVRQVGLLAAGCQPWNKDVCAASGDRFAYCATLAIYIYQLDHRYNEFKLHAIMSEHKK 60

Query: 61   TITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDVVAF 120
            TITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDVVAF
Sbjct: 61   TITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDVVAF 120

Query: 121  VSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGHIDGSLSIFHPG 180
            VSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGHIDGSLSIFHPG
Sbjct: 121  VSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGHIDGSLSIFHPG 180

Query: 181  NKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLLVVNLHYGIRLVDSESLSCITTFNL 240
            NKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLLVVNLHYGIRLVDSESLSCITTFNL
Sbjct: 181  NKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLLVVNLHYGIRLVDSESLSCITTFNL 240

Query: 241  PSAAASVQCLAWVPSAPGMFITGDSQVGVLRIWNVSRTTPIDNLKLKKTGFHCLHVLNSP 300
            PSAAASVQCLAWVPSAPGMFITGDSQVGVLRIWNVSRTTPIDNLKLKKTGFHCLHVLNSP
Sbjct: 241  PSAAASVQCLAWVPSAPGMFITGDSQVGVLRIWNVSRTTPIDNLKLKKTGFHCLHVLNSP 300

Query: 301  PRKKFSVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKW 360
            PRKKFSVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKW
Sbjct: 301  PRKKFSVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKW 360

Query: 361  DFLRDLGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSW 420
            DFLRDLGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSW
Sbjct: 361  DFLRDLGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSW 420

Query: 421  APGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGF 480
            APGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGF
Sbjct: 421  APGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGF 480

Query: 481  CIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSG 540
            CIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSG
Sbjct: 481  CIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSG 540

Query: 541  HTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYL 600
            HTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYL
Sbjct: 541  HTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYL 600

Query: 601  LISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTA 660
            LISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTA
Sbjct: 601  LISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTA 660

Query: 661  LVTPVQINILADRSWEEIIGNTDYAIEPGTPPLLCGKVSRDIRQEIEKLTANSQVKKLRW 720
            LVTPVQINILADRSWEEIIGNTDYAIEPGTPPLLCGKVSRDIRQEIEKLTANSQVKKLRW
Sbjct: 661  LVTPVQINILADRSWEEIIGNTDYAIEPGTPPLLCGKVSRDIRQEIEKLTANSQVKKLRW 720

Query: 721  FSECLSPPGGSDNLWNLVAVIKGQDDSLLPQNYCKGIMHLKHLIKFRTSEAQELTTVKMS 780
            FSECLSPPGGSDNLWNLVAVIKGQDDSLLPQNYCKGIMHLKHLIKFRTSEAQELTTVKMS
Sbjct: 721  FSECLSPPGGSDNLWNLVAVIKGQDDSLLPQNYCKGIMHLKHLIKFRTSEAQELTTVKMS 780

Query: 781  KFGGGIGVPAKEERLKEAAEIHLRLGQIQRYCELMVELGEWDKALSIAPGVSVKYWKKLM 840
            KFGGGIGVPAKEERLKEAAEIHLRLGQIQRYCELMVELGEWDKALSIAPGVSVKYWKKLM
Sbjct: 781  KFGGGIGVPAKEERLKEAAEIHLRLGQIQRYCELMVELGEWDKALSIAPGVSVKYWKKLM 840

Query: 841  QRRADQLIQEDKDDVIPYCIAIGDVKKLVHFFMSRGQLKEALLVAQAACEGNMQPLHVSV 900
            QRRADQLIQEDKDDVIPYCIAIGDVKKLVHFFMSRGQLKEALLVAQAACEGNMQPLHVSV
Sbjct: 841  QRRADQLIQEDKDDVIPYCIAIGDVKKLVHFFMSRGQLKEALLVAQAACEGNMQPLHVSV 900

Query: 901  PKGASYSDDIYKEDFNELLHKVSKELAEWYFQDGRAVLAACCHLAIDNIELAMAYLIRGN 960
            PKGASYSDDIYKEDFNELLHKVSKELAEWYFQDGRAVLAACCHLAIDNIELAMAYLIRGN
Sbjct: 901  PKGASYSDDIYKEDFNELLHKVSKELAEWYFQDGRAVLAACCHLAIDNIELAMAYLIRGN 960

Query: 961  ELELAVCVGTVLGESAAPATHYALELLARKCMMISVCFPCVGYSVPFCYVNRNLAADLLL 1020
            ELELAVCVGTVLGESAAPATHYALELLARKCMMISVCFPCVGYSVPFCYVNRNLAADLLL
Sbjct: 961  ELELAVCVGTVLGESAAPATHYALELLARKCMMISVCFPCVGYSVPFCYVNRNLAADLLL 1020

Query: 1021 MIPDNELHLIKLCAFYPGCTEEINDLHDKCKLPTVEECMQLAETARADDNIFETVKYYLL 1080
            MIPDNELHLIKLCAFYPGCTEEINDLHDKCKLPTVEECMQLAETARADDNIFETVKYYLL
Sbjct: 1021 MIPDNELHLIKLCAFYPGCTEEINDLHDKCKLPTVEECMQLAETARADDNIFETVKYYLL 1080

Query: 1081 SQEPEKALPIGISFVKEYISSSDWTLDTIYPVLDLLSYIRTEKLLLHTCTEARNELLILC 1140
            SQEPEKALPIGISFVKEYISSSDWTLDTIYPVLDLLSYIRTEKLLLHTCTEARNELLILC
Sbjct: 1081 SQEPEKALPIGISFVKEYISSSDWTLDTIYPVLDLLSYIRTEKLLLHTCTEARNELLILC 1140

Query: 1141 GYIGALLAIRRQYQSIVPALYEYTSQLLKRREVSVPLKIEYLSEELDAWRACTQSTNRSL 1200
            GYIGALLAIRRQYQSIVPALYEYTSQLLKRREVSVPLKIEYLSEELDAWRACTQSTNRSL
Sbjct: 1141 GYIGALLAIRRQYQSIVPALYEYTSQLLKRREVSVPLKIEYLSEELDAWRACTQSTNRSL 1200

Query: 1201 EDSPYTPPSDSQRMIYATLLKRLKEESLKGIIGPDYVTGSNLPSHSDIHISCLTGLKIQG 1260
            EDSPYTPPSDSQRMIYATLLKRLKEESLKGIIGPDYVTGSNLPSHSDIHISCLTGLKIQG
Sbjct: 1201 EDSPYTPPSDSQRMIYATLLKRLKEESLKGIIGPDYVTGSNLPSHSDIHISCLTGLKIQG 1260

Query: 1261 PVFFLEDGKSAISLNDALMWAKVNPFSPLGTGIRLNPF 1298
            PVFFLEDGKSAISLNDALMWAKVNPFSPLGTGIRLNPF
Sbjct: 1261 PVFFLEDGKSAISLNDALMWAKVNPFSPLGTGIRLNPF 1298


>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
          Length = 1322

 Score = 2681 bits (6950), Expect = 0.0
 Identities = 1298/1298 (100%), Positives = 1298/1298 (100%)

Query: 1    MSQVRQVGLLAAGCQPWNKDVCAASGDRFAYCATLAIYIYQLDHRYNEFKLHAIMSEHKK 60
            MSQVRQVGLLAAGCQPWNKDVCAASGDRFAYCATLAIYIYQLDHRYNEFKLHAIMSEHKK
Sbjct: 25   MSQVRQVGLLAAGCQPWNKDVCAASGDRFAYCATLAIYIYQLDHRYNEFKLHAIMSEHKK 84

Query: 61   TITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDVVAF 120
            TITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDVVAF
Sbjct: 85   TITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDVVAF 144

Query: 121  VSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGHIDGSLSIFHPG 180
            VSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGHIDGSLSIFHPG
Sbjct: 145  VSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGHIDGSLSIFHPG 204

Query: 181  NKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLLVVNLHYGIRLVDSESLSCITTFNL 240
            NKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLLVVNLHYGIRLVDSESLSCITTFNL
Sbjct: 205  NKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLLVVNLHYGIRLVDSESLSCITTFNL 264

Query: 241  PSAAASVQCLAWVPSAPGMFITGDSQVGVLRIWNVSRTTPIDNLKLKKTGFHCLHVLNSP 300
            PSAAASVQCLAWVPSAPGMFITGDSQVGVLRIWNVSRTTPIDNLKLKKTGFHCLHVLNSP
Sbjct: 265  PSAAASVQCLAWVPSAPGMFITGDSQVGVLRIWNVSRTTPIDNLKLKKTGFHCLHVLNSP 324

Query: 301  PRKKFSVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKW 360
            PRKKFSVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKW
Sbjct: 325  PRKKFSVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKW 384

Query: 361  DFLRDLGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSW 420
            DFLRDLGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSW
Sbjct: 385  DFLRDLGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSW 444

Query: 421  APGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGF 480
            APGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGF
Sbjct: 445  APGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGF 504

Query: 481  CIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSG 540
            CIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSG
Sbjct: 505  CIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSG 564

Query: 541  HTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYL 600
            HTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYL
Sbjct: 565  HTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYL 624

Query: 601  LISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTA 660
            LISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTA
Sbjct: 625  LISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTA 684

Query: 661  LVTPVQINILADRSWEEIIGNTDYAIEPGTPPLLCGKVSRDIRQEIEKLTANSQVKKLRW 720
            LVTPVQINILADRSWEEIIGNTDYAIEPGTPPLLCGKVSRDIRQEIEKLTANSQVKKLRW
Sbjct: 685  LVTPVQINILADRSWEEIIGNTDYAIEPGTPPLLCGKVSRDIRQEIEKLTANSQVKKLRW 744

Query: 721  FSECLSPPGGSDNLWNLVAVIKGQDDSLLPQNYCKGIMHLKHLIKFRTSEAQELTTVKMS 780
            FSECLSPPGGSDNLWNLVAVIKGQDDSLLPQNYCKGIMHLKHLIKFRTSEAQELTTVKMS
Sbjct: 745  FSECLSPPGGSDNLWNLVAVIKGQDDSLLPQNYCKGIMHLKHLIKFRTSEAQELTTVKMS 804

Query: 781  KFGGGIGVPAKEERLKEAAEIHLRLGQIQRYCELMVELGEWDKALSIAPGVSVKYWKKLM 840
            KFGGGIGVPAKEERLKEAAEIHLRLGQIQRYCELMVELGEWDKALSIAPGVSVKYWKKLM
Sbjct: 805  KFGGGIGVPAKEERLKEAAEIHLRLGQIQRYCELMVELGEWDKALSIAPGVSVKYWKKLM 864

Query: 841  QRRADQLIQEDKDDVIPYCIAIGDVKKLVHFFMSRGQLKEALLVAQAACEGNMQPLHVSV 900
            QRRADQLIQEDKDDVIPYCIAIGDVKKLVHFFMSRGQLKEALLVAQAACEGNMQPLHVSV
Sbjct: 865  QRRADQLIQEDKDDVIPYCIAIGDVKKLVHFFMSRGQLKEALLVAQAACEGNMQPLHVSV 924

Query: 901  PKGASYSDDIYKEDFNELLHKVSKELAEWYFQDGRAVLAACCHLAIDNIELAMAYLIRGN 960
            PKGASYSDDIYKEDFNELLHKVSKELAEWYFQDGRAVLAACCHLAIDNIELAMAYLIRGN
Sbjct: 925  PKGASYSDDIYKEDFNELLHKVSKELAEWYFQDGRAVLAACCHLAIDNIELAMAYLIRGN 984

Query: 961  ELELAVCVGTVLGESAAPATHYALELLARKCMMISVCFPCVGYSVPFCYVNRNLAADLLL 1020
            ELELAVCVGTVLGESAAPATHYALELLARKCMMISVCFPCVGYSVPFCYVNRNLAADLLL
Sbjct: 985  ELELAVCVGTVLGESAAPATHYALELLARKCMMISVCFPCVGYSVPFCYVNRNLAADLLL 1044

Query: 1021 MIPDNELHLIKLCAFYPGCTEEINDLHDKCKLPTVEECMQLAETARADDNIFETVKYYLL 1080
            MIPDNELHLIKLCAFYPGCTEEINDLHDKCKLPTVEECMQLAETARADDNIFETVKYYLL
Sbjct: 1045 MIPDNELHLIKLCAFYPGCTEEINDLHDKCKLPTVEECMQLAETARADDNIFETVKYYLL 1104

Query: 1081 SQEPEKALPIGISFVKEYISSSDWTLDTIYPVLDLLSYIRTEKLLLHTCTEARNELLILC 1140
            SQEPEKALPIGISFVKEYISSSDWTLDTIYPVLDLLSYIRTEKLLLHTCTEARNELLILC
Sbjct: 1105 SQEPEKALPIGISFVKEYISSSDWTLDTIYPVLDLLSYIRTEKLLLHTCTEARNELLILC 1164

Query: 1141 GYIGALLAIRRQYQSIVPALYEYTSQLLKRREVSVPLKIEYLSEELDAWRACTQSTNRSL 1200
            GYIGALLAIRRQYQSIVPALYEYTSQLLKRREVSVPLKIEYLSEELDAWRACTQSTNRSL
Sbjct: 1165 GYIGALLAIRRQYQSIVPALYEYTSQLLKRREVSVPLKIEYLSEELDAWRACTQSTNRSL 1224

Query: 1201 EDSPYTPPSDSQRMIYATLLKRLKEESLKGIIGPDYVTGSNLPSHSDIHISCLTGLKIQG 1260
            EDSPYTPPSDSQRMIYATLLKRLKEESLKGIIGPDYVTGSNLPSHSDIHISCLTGLKIQG
Sbjct: 1225 EDSPYTPPSDSQRMIYATLLKRLKEESLKGIIGPDYVTGSNLPSHSDIHISCLTGLKIQG 1284

Query: 1261 PVFFLEDGKSAISLNDALMWAKVNPFSPLGTGIRLNPF 1298
            PVFFLEDGKSAISLNDALMWAKVNPFSPLGTGIRLNPF
Sbjct: 1285 PVFFLEDGKSAISLNDALMWAKVNPFSPLGTGIRLNPF 1322


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score =  124 bits (310), Expect = 8e-28
 Identities = 104/376 (27%), Positives = 166/376 (44%), Gaps = 49/376 (13%)

Query: 306 SVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD 365
           S Q+P+KN   +   E        +N+A S+   HA    +DG V   ++ + K   LR 
Sbjct: 132 SHQNPSKNREATVNGE--------ENRAHSVN-NHAKPMEIDGEV---EIPSSKATVLR- 178

Query: 366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLT---------------AVYTSPG 410
            GH   +F C + P   +LLA+ S D T ++W++N  +                 +  P 
Sbjct: 179 -GHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236

Query: 411 NEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSK 470
           N+ V  SL W   G   +A G+    A IW  + G +     +H    IF + W+ K + 
Sbjct: 237 NKDVT-SLDWNTNG-TLLATGSYDGFARIWT-EDGNLASTLGQH-KGPIFALKWNRKGNY 292

Query: 471 RIATCSSDGFCIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVAT 529
            ++        I     G+   ++  H A     DW QNN    +     T++ ++    
Sbjct: 293 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCS---TDMCIHVCRL 348

Query: 530 SSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVR 589
             D+P+K F GHT +V  +KW P    +L S SDD T++IW   Q+ CI+ L  H   + 
Sbjct: 349 GCDRPVKTFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 407

Query: 590 GLMWNTEIP--------YLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP 641
            + W+   P         +L S S+D T+++WD   G C  T+  H   VY +   P   
Sbjct: 408 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK 467

Query: 642 FTMASCSRDSTVRLWS 657
           + +AS S D  V +W+
Sbjct: 468 Y-LASGSFDKCVHIWN 482



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 41/144 (28%), Positives = 71/144 (49%), Gaps = 17/144 (11%)

Query: 354 DMGAKKWDFLRDL------GHVETIFDCKFKPDDPN--------LLATASFDGTIKVWDI 399
           DM  K W   +++       H + I+  K+ P  P         +LA+ASFD T+++WDI
Sbjct: 382 DMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 441

Query: 400 NTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGI 459
                 +T   ++  +YS++++P G   +A G+      IWN Q G ++  +   GT GI
Sbjct: 442 ERGVCTHTLTKHQEPVYSVAFSPDG-KYLASGSFDKCVHIWNTQSGNLVHSY--RGTGGI 498

Query: 460 FCIAWSHKDSKRIATCSSDGFCII 483
           F + W+ +  K  A+ S    C++
Sbjct: 499 FEVCWNARGDKVGASASDGSVCVL 522



 Score = 34.7 bits (78), Expect = 0.61
 Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 4/60 (6%)

Query: 55  MSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNA 114
           +++H++ + ++++ P    L ASGS D  V IWN     ++     T GI      CWNA
Sbjct: 450 LTKHQEPVYSVAFSPDGKYL-ASGSFDKCVHIWNTQSGNLVHSYRGTGGI---FEVCWNA 505


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score =  124 bits (310), Expect = 8e-28
 Identities = 104/376 (27%), Positives = 166/376 (44%), Gaps = 49/376 (13%)

Query: 306 SVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD 365
           S Q+P+KN   +   E        +N+A S+   HA    +DG V   ++ + K   LR 
Sbjct: 132 SHQNPSKNREATVNGE--------ENRAHSVN-NHAKPMEIDGEV---EIPSSKATVLR- 178

Query: 366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLT---------------AVYTSPG 410
            GH   +F C + P   +LLA+ S D T ++W++N  +                 +  P 
Sbjct: 179 -GHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236

Query: 411 NEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSK 470
           N+ V  SL W   G   +A G+    A IW  + G +     +H    IF + W+ K + 
Sbjct: 237 NKDVT-SLDWNTNG-TLLATGSYDGFARIWT-EDGNLASTLGQH-KGPIFALKWNRKGNY 292

Query: 471 RIATCSSDGFCIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVAT 529
            ++        I     G+   ++  H A     DW QNN    +     T++ ++    
Sbjct: 293 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCS---TDMCIHVCRL 348

Query: 530 SSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVR 589
             D+P+K F GHT +V  +KW P    +L S SDD T++IW   Q+ CI+ L  H   + 
Sbjct: 349 GCDRPVKTFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 407

Query: 590 GLMWNTEIP--------YLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP 641
            + W+   P         +L S S+D T+++WD   G C  T+  H   VY +   P   
Sbjct: 408 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK 467

Query: 642 FTMASCSRDSTVRLWS 657
           + +AS S D  V +W+
Sbjct: 468 Y-LASGSFDKCVHIWN 482



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 41/144 (28%), Positives = 71/144 (49%), Gaps = 17/144 (11%)

Query: 354 DMGAKKWDFLRDL------GHVETIFDCKFKPDDPN--------LLATASFDGTIKVWDI 399
           DM  K W   +++       H + I+  K+ P  P         +LA+ASFD T+++WDI
Sbjct: 382 DMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 441

Query: 400 NTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGI 459
                 +T   ++  +YS++++P G   +A G+      IWN Q G ++  +   GT GI
Sbjct: 442 ERGVCTHTLTKHQEPVYSVAFSPDG-KYLASGSFDKCVHIWNTQSGNLVHSY--RGTGGI 498

Query: 460 FCIAWSHKDSKRIATCSSDGFCII 483
           F + W+ +  K  A+ S    C++
Sbjct: 499 FEVCWNARGDKVGASASDGSVCVL 522



 Score = 34.7 bits (78), Expect = 0.61
 Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 4/60 (6%)

Query: 55  MSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNA 114
           +++H++ + ++++ P    L ASGS D  V IWN     ++     T GI      CWNA
Sbjct: 450 LTKHQEPVYSVAFSPDGKYL-ASGSFDKCVHIWNTQSGNLVHSYRGTGGI---FEVCWNA 505


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score =  124 bits (310), Expect = 8e-28
 Identities = 104/376 (27%), Positives = 166/376 (44%), Gaps = 49/376 (13%)

Query: 306 SVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD 365
           S Q+P+KN   +   E        +N+A S+   HA    +DG V   ++ + K   LR 
Sbjct: 183 SHQNPSKNREATVNGE--------ENRAHSVN-NHAKPMEIDGEV---EIPSSKATVLR- 229

Query: 366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLT---------------AVYTSPG 410
            GH   +F C + P   +LLA+ S D T ++W++N  +                 +  P 
Sbjct: 230 -GHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287

Query: 411 NEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSK 470
           N+ V  SL W   G   +A G+    A IW  + G +     +H    IF + W+ K + 
Sbjct: 288 NKDVT-SLDWNTNG-TLLATGSYDGFARIWT-EDGNLASTLGQH-KGPIFALKWNRKGNY 343

Query: 471 RIATCSSDGFCIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVAT 529
            ++        I     G+   ++  H A     DW QNN    +     T++ ++    
Sbjct: 344 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCS---TDMCIHVCRL 399

Query: 530 SSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVR 589
             D+P+K F GHT +V  +KW P    +L S SDD T++IW   Q+ CI+ L  H   + 
Sbjct: 400 GCDRPVKTFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458

Query: 590 GLMWNTEIP--------YLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP 641
            + W+   P         +L S S+D T+++WD   G C  T+  H   VY +   P   
Sbjct: 459 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK 518

Query: 642 FTMASCSRDSTVRLWS 657
           + +AS S D  V +W+
Sbjct: 519 Y-LASGSFDKCVHIWN 533



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 41/144 (28%), Positives = 71/144 (49%), Gaps = 17/144 (11%)

Query: 354 DMGAKKWDFLRDL------GHVETIFDCKFKPDDPN--------LLATASFDGTIKVWDI 399
           DM  K W   +++       H + I+  K+ P  P         +LA+ASFD T+++WDI
Sbjct: 433 DMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 492

Query: 400 NTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGI 459
                 +T   ++  +YS++++P G   +A G+      IWN Q G ++  +   GT GI
Sbjct: 493 ERGVCTHTLTKHQEPVYSVAFSPDG-KYLASGSFDKCVHIWNTQSGNLVHSY--RGTGGI 549

Query: 460 FCIAWSHKDSKRIATCSSDGFCII 483
           F + W+ +  K  A+ S    C++
Sbjct: 550 FEVCWNARGDKVGASASDGSVCVL 573



 Score = 34.7 bits (78), Expect = 0.61
 Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 4/60 (6%)

Query: 55  MSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNA 114
           +++H++ + ++++ P    L ASGS D  V IWN     ++     T GI      CWNA
Sbjct: 501 LTKHQEPVYSVAFSPDGKYL-ASGSFDKCVHIWNTQSGNLVHSYRGTGGI---FEVCWNA 556


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score =  124 bits (310), Expect = 8e-28
 Identities = 104/376 (27%), Positives = 166/376 (44%), Gaps = 49/376 (13%)

Query: 306 SVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD 365
           S Q+P+KN   +   E        +N+A S+   HA    +DG V   ++ + K   LR 
Sbjct: 183 SHQNPSKNREATVNGE--------ENRAHSVN-NHAKPMEIDGEV---EIPSSKATVLR- 229

Query: 366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLT---------------AVYTSPG 410
            GH   +F C + P   +LLA+ S D T ++W++N  +                 +  P 
Sbjct: 230 -GHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287

Query: 411 NEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSK 470
           N+ V  SL W   G   +A G+    A IW  + G +     +H    IF + W+ K + 
Sbjct: 288 NKDVT-SLDWNTNG-TLLATGSYDGFARIWT-EDGNLASTLGQH-KGPIFALKWNRKGNY 343

Query: 471 RIATCSSDGFCIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVAT 529
            ++        I     G+   ++  H A     DW QNN    +     T++ ++    
Sbjct: 344 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCS---TDMCIHVCRL 399

Query: 530 SSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVR 589
             D+P+K F GHT +V  +KW P    +L S SDD T++IW   Q+ CI+ L  H   + 
Sbjct: 400 GCDRPVKTFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458

Query: 590 GLMWNTEIP--------YLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP 641
            + W+   P         +L S S+D T+++WD   G C  T+  H   VY +   P   
Sbjct: 459 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK 518

Query: 642 FTMASCSRDSTVRLWS 657
           + +AS S D  V +W+
Sbjct: 519 Y-LASGSFDKCVHIWN 533



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 41/144 (28%), Positives = 71/144 (49%), Gaps = 17/144 (11%)

Query: 354 DMGAKKWDFLRDL------GHVETIFDCKFKPDDPN--------LLATASFDGTIKVWDI 399
           DM  K W   +++       H + I+  K+ P  P         +LA+ASFD T+++WDI
Sbjct: 433 DMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 492

Query: 400 NTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGI 459
                 +T   ++  +YS++++P G   +A G+      IWN Q G ++  +   GT GI
Sbjct: 493 ERGVCTHTLTKHQEPVYSVAFSPDG-KYLASGSFDKCVHIWNTQSGNLVHSY--RGTGGI 549

Query: 460 FCIAWSHKDSKRIATCSSDGFCII 483
           F + W+ +  K  A+ S    C++
Sbjct: 550 FEVCWNARGDKVGASASDGSVCVL 573



 Score = 34.7 bits (78), Expect = 0.61
 Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 4/60 (6%)

Query: 55  MSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNA 114
           +++H++ + ++++ P    L ASGS D  V IWN     ++     T GI      CWNA
Sbjct: 501 LTKHQEPVYSVAFSPDGKYL-ASGSFDKCVHIWNTQSGNLVHSYRGTGGI---FEVCWNA 556


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  124 bits (310), Expect = 8e-28
 Identities = 103/376 (27%), Positives = 162/376 (43%), Gaps = 49/376 (13%)

Query: 306 SVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD 365
           S Q+P KN   +   E        +N A  +   H+    +DG V   ++   K   LR 
Sbjct: 130 SQQNPPKNREATVNGE--------ENGAHEIN-NHSKPMEIDGDV---EIPPNKATVLR- 176

Query: 366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLT---------------AVYTSPG 410
            GH   +F C + P   +LLA+ S D T ++W++N  +                 +  P 
Sbjct: 177 -GHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234

Query: 411 NEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSK 470
           N+ V  SL W   G   +A G+    A IW  + G +     +H    IF + W+ K + 
Sbjct: 235 NKDVT-SLDWNSDG-TLLAMGSYDGFARIWT-ENGNLASTLGQH-KGPIFALKWNKKGNY 290

Query: 471 RIATCSSDGFCIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVAT 529
            ++        I     G+   ++  H A     DW  N   M    C  T++ ++    
Sbjct: 291 VLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNN---MTFASCS-TDMCIHVCRL 346

Query: 530 SSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVR 589
             D P+K F GHT +V  +KW P    +L S SDD T++IW   QDAC++ L  H+  + 
Sbjct: 347 GCDHPVKTFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQDACVHDLQAHSKEIY 405

Query: 590 GLMW--------NTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP 641
            + W        N     +L S S+D T+++WD  +G C  T+  H   VY +   P   
Sbjct: 406 TIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGK 465

Query: 642 FTMASCSRDSTVRLWS 657
           + +AS S D  V +W+
Sbjct: 466 Y-LASGSFDKYVHIWN 480



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 69/266 (25%), Positives = 121/266 (45%), Gaps = 35/266 (13%)

Query: 381 DPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIW 440
           D  LLA  S+DG  ++W  N   A  T   ++G I++L W   G   ++ G  +    IW
Sbjct: 246 DGTLLAMGSYDGFARIWTENGNLAS-TLGQHKGPIFALKWNKKGNYVLSAGVDKT-TIIW 303

Query: 441 NVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCI----------IRTIDGKV 490
           +   G+  Q+F  H    +  + W  +++   A+CS+D  CI          ++T  G  
Sbjct: 304 DAHTGEAKQQFPFHSAPALD-VDW--QNNMTFASCSTD-MCIHVCRLGCDHPVKTFQG-- 357

Query: 491 LHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKW 550
                H   V    W  +   ++A+  +D  ++++  +   D  +     H+ +++ +KW
Sbjct: 358 -----HTNEVNAIKWDPSGM-LLASCSDDMTLKIW--SMKQDACVHDLQAHSKEIYTIKW 409

Query: 551 SPLREG--------ILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLI 602
           SP            +L S S D TVR+WD  Q  C + L  H  PV  + ++ +  YL  
Sbjct: 410 SPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLA- 468

Query: 603 SGSWDYTIKVWDTREGTCVDTVYDHG 628
           SGS+D  + +W+T+ G+ V +    G
Sbjct: 469 SGSFDKYVHIWNTQSGSLVHSYQGTG 494



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 68/271 (25%), Positives = 114/271 (42%), Gaps = 30/271 (11%)

Query: 410 GNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQK---GKIIQRFNEH----------GT 456
           G+E  ++  +W P   + +A G+  + A IWN+ +   G   Q    H            
Sbjct: 177 GHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235

Query: 457 NGIFCIAWSHKDSKRIATCSSDGFCIIRTIDGKVLHKY-KHPAAVFGCDWSQNNKDMIAT 515
             +  + W+  D   +A  S DGF  I T +G +     +H   +F   W++    +++ 
Sbjct: 236 KDVTSLDWN-SDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSA 294

Query: 516 GCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQD 575
           G + T + ++   T   +  + F  H+A    V W         S S D  + +     D
Sbjct: 295 GVDKTTI-IWDAHTGEAK--QQFPFHSAPALDVDWQ--NNMTFASCSTDMCIHVCRLGCD 349

Query: 576 ACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLT 635
             +    GHT  V  + W+     LL S S D T+K+W  ++  CV  +  H  ++Y + 
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIK 408

Query: 636 CHPSRPFT--------MASCSRDSTVRLWSL 658
             P+ P T        +AS S DSTVRLW +
Sbjct: 409 WSPTGPATSNPNSSIMLASASFDSTVRLWDV 439



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 41/144 (28%), Positives = 70/144 (48%), Gaps = 17/144 (11%)

Query: 354 DMGAKKWDFLRDL------GHVETIFDCKFKPDDPN--------LLATASFDGTIKVWDI 399
           DM  K W   +D        H + I+  K+ P  P         +LA+ASFD T+++WD+
Sbjct: 380 DMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDV 439

Query: 400 NTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGI 459
                 +T   ++  +YS++++P G   +A G+      IWN Q G ++  +   GT GI
Sbjct: 440 EQGVCTHTLMKHQEPVYSVAFSPDG-KYLASGSFDKYVHIWNTQSGSLVHSY--QGTGGI 496

Query: 460 FCIAWSHKDSKRIATCSSDGFCII 483
           F + W+ +  K  A+ S    C++
Sbjct: 497 FEVCWNARGDKVGASASDGSVCVL 520



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 90/398 (22%), Positives = 155/398 (38%), Gaps = 93/398 (23%)

Query: 54  IMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAE-------QKVIAKLDSTKG--I 104
           ++  H+  +   +W P + DL ASGS D+   IWN+ E       Q V+       G  +
Sbjct: 174 VLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232

Query: 105 PAS---LSWCWNAE-DVVAFVSHRGPLFIWTISGPDSGVI-VHKDAHSFLSDICMFRWHT 159
           P++    S  WN++  ++A  S+ G   IWT +G  +  +  HK        I   +W  
Sbjct: 233 PSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHK------GPIFALKW-- 284

Query: 160 HQKGK-VVFGHIDGSLSIF--HPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLL 216
           ++KG  V+   +D +  I+  H G   Q+           D ++ +T   +   STD  +
Sbjct: 285 NKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMT---FASCSTDMCI 341

Query: 217 VVNLHYGIRLVDSESLSC---ITTFNLPSAAASVQCLAWVPSAPGMFITGDSQVGVLRIW 273
            V             L C   + TF        V  + W PS  GM +   S    L+IW
Sbjct: 342 HVC-----------RLGCDHPVKTFQ--GHTNEVNAIKWDPS--GMLLASCSDDMTLKIW 386

Query: 274 NVSRTTPIDNLKLKKTGFHCLHVLNSPPRKKFSVQ-SPTKNHYTSSTSEAVPPPTLTQNQ 332
           ++ +               C+H L +  ++ ++++ SPT             P T   N 
Sbjct: 387 SMKQDA-------------CVHDLQAHSKEIYTIKWSPT------------GPATSNPNS 421

Query: 333 AFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD------LGHVETIFDCKFKPDDPNLLA 386
           +  L                +D   + WD  +       + H E ++   F PD    LA
Sbjct: 422 SIMLASAS------------FDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDG-KYLA 468

Query: 387 TASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGG 424
           + SFD  + +W+  + + V++  G  G I+ + W   G
Sbjct: 469 SGSFDKYVHIWNTQSGSLVHSYQGTGG-IFEVCWNARG 505


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  124 bits (310), Expect = 8e-28
 Identities = 103/376 (27%), Positives = 162/376 (43%), Gaps = 49/376 (13%)

Query: 306 SVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD 365
           S Q+P KN   +   E        +N A  +   H+    +DG V   ++   K   LR 
Sbjct: 130 SQQNPPKNREATVNGE--------ENGAHEIN-NHSKPMEIDGDV---EIPPNKATVLR- 176

Query: 366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLT---------------AVYTSPG 410
            GH   +F C + P   +LLA+ S D T ++W++N  +                 +  P 
Sbjct: 177 -GHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234

Query: 411 NEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSK 470
           N+ V  SL W   G   +A G+    A IW  + G +     +H    IF + W+ K + 
Sbjct: 235 NKDVT-SLDWNSDG-TLLAMGSYDGFARIWT-ENGNLASTLGQH-KGPIFALKWNKKGNY 290

Query: 471 RIATCSSDGFCIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVAT 529
            ++        I     G+   ++  H A     DW  N   M    C  T++ ++    
Sbjct: 291 VLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNN---MTFASCS-TDMCIHVCRL 346

Query: 530 SSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVR 589
             D P+K F GHT +V  +KW P    +L S SDD T++IW   QDAC++ L  H+  + 
Sbjct: 347 GCDHPVKTFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQDACVHDLQAHSKEIY 405

Query: 590 GLMW--------NTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP 641
            + W        N     +L S S+D T+++WD  +G C  T+  H   VY +   P   
Sbjct: 406 TIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGK 465

Query: 642 FTMASCSRDSTVRLWS 657
           + +AS S D  V +W+
Sbjct: 466 Y-LASGSFDKYVHIWN 480



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 69/266 (25%), Positives = 121/266 (45%), Gaps = 35/266 (13%)

Query: 381 DPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIW 440
           D  LLA  S+DG  ++W  N   A  T   ++G I++L W   G   ++ G  +    IW
Sbjct: 246 DGTLLAMGSYDGFARIWTENGNLAS-TLGQHKGPIFALKWNKKGNYVLSAGVDKT-TIIW 303

Query: 441 NVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCI----------IRTIDGKV 490
           +   G+  Q+F  H    +  + W  +++   A+CS+D  CI          ++T  G  
Sbjct: 304 DAHTGEAKQQFPFHSAPALD-VDW--QNNMTFASCSTD-MCIHVCRLGCDHPVKTFQG-- 357

Query: 491 LHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKW 550
                H   V    W  +   ++A+  +D  ++++  +   D  +     H+ +++ +KW
Sbjct: 358 -----HTNEVNAIKWDPSGM-LLASCSDDMTLKIW--SMKQDACVHDLQAHSKEIYTIKW 409

Query: 551 SPLREG--------ILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLI 602
           SP            +L S S D TVR+WD  Q  C + L  H  PV  + ++ +  YL  
Sbjct: 410 SPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLA- 468

Query: 603 SGSWDYTIKVWDTREGTCVDTVYDHG 628
           SGS+D  + +W+T+ G+ V +    G
Sbjct: 469 SGSFDKYVHIWNTQSGSLVHSYQGTG 494



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 68/271 (25%), Positives = 114/271 (42%), Gaps = 30/271 (11%)

Query: 410 GNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQK---GKIIQRFNEH----------GT 456
           G+E  ++  +W P   + +A G+  + A IWN+ +   G   Q    H            
Sbjct: 177 GHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235

Query: 457 NGIFCIAWSHKDSKRIATCSSDGFCIIRTIDGKVLHKY-KHPAAVFGCDWSQNNKDMIAT 515
             +  + W+  D   +A  S DGF  I T +G +     +H   +F   W++    +++ 
Sbjct: 236 KDVTSLDWN-SDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSA 294

Query: 516 GCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQD 575
           G + T + ++   T   +  + F  H+A    V W         S S D  + +     D
Sbjct: 295 GVDKTTI-IWDAHTGEAK--QQFPFHSAPALDVDWQ--NNMTFASCSTDMCIHVCRLGCD 349

Query: 576 ACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLT 635
             +    GHT  V  + W+     LL S S D T+K+W  ++  CV  +  H  ++Y + 
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIK 408

Query: 636 CHPSRPFT--------MASCSRDSTVRLWSL 658
             P+ P T        +AS S DSTVRLW +
Sbjct: 409 WSPTGPATSNPNSSIMLASASFDSTVRLWDV 439



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 41/144 (28%), Positives = 70/144 (48%), Gaps = 17/144 (11%)

Query: 354 DMGAKKWDFLRDL------GHVETIFDCKFKPDDPN--------LLATASFDGTIKVWDI 399
           DM  K W   +D        H + I+  K+ P  P         +LA+ASFD T+++WD+
Sbjct: 380 DMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDV 439

Query: 400 NTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGI 459
                 +T   ++  +YS++++P G   +A G+      IWN Q G ++  +   GT GI
Sbjct: 440 EQGVCTHTLMKHQEPVYSVAFSPDG-KYLASGSFDKYVHIWNTQSGSLVHSY--QGTGGI 496

Query: 460 FCIAWSHKDSKRIATCSSDGFCII 483
           F + W+ +  K  A+ S    C++
Sbjct: 497 FEVCWNARGDKVGASASDGSVCVL 520



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 90/398 (22%), Positives = 155/398 (38%), Gaps = 93/398 (23%)

Query: 54  IMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAE-------QKVIAKLDSTKG--I 104
           ++  H+  +   +W P + DL ASGS D+   IWN+ E       Q V+       G  +
Sbjct: 174 VLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232

Query: 105 PAS---LSWCWNAE-DVVAFVSHRGPLFIWTISGPDSGVI-VHKDAHSFLSDICMFRWHT 159
           P++    S  WN++  ++A  S+ G   IWT +G  +  +  HK        I   +W  
Sbjct: 233 PSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHK------GPIFALKW-- 284

Query: 160 HQKGK-VVFGHIDGSLSIF--HPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLL 216
           ++KG  V+   +D +  I+  H G   Q+           D ++ +T   +   STD  +
Sbjct: 285 NKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMT---FASCSTDMCI 341

Query: 217 VVNLHYGIRLVDSESLSC---ITTFNLPSAAASVQCLAWVPSAPGMFITGDSQVGVLRIW 273
            V             L C   + TF        V  + W PS  GM +   S    L+IW
Sbjct: 342 HVC-----------RLGCDHPVKTFQ--GHTNEVNAIKWDPS--GMLLASCSDDMTLKIW 386

Query: 274 NVSRTTPIDNLKLKKTGFHCLHVLNSPPRKKFSVQ-SPTKNHYTSSTSEAVPPPTLTQNQ 332
           ++ +               C+H L +  ++ ++++ SPT             P T   N 
Sbjct: 387 SMKQDA-------------CVHDLQAHSKEIYTIKWSPT------------GPATSNPNS 421

Query: 333 AFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD------LGHVETIFDCKFKPDDPNLLA 386
           +  L                +D   + WD  +       + H E ++   F PD    LA
Sbjct: 422 SIMLASAS------------FDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDG-KYLA 468

Query: 387 TASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGG 424
           + SFD  + +W+  + + V++  G  G I+ + W   G
Sbjct: 469 SGSFDKYVHIWNTQSGSLVHSYQGTGG-IFEVCWNARG 505


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  124 bits (310), Expect = 8e-28
 Identities = 103/376 (27%), Positives = 162/376 (43%), Gaps = 49/376 (13%)

Query: 306 SVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD 365
           S Q+P KN   +   E        +N A  +   H+    +DG V   ++   K   LR 
Sbjct: 130 SQQNPPKNREATVNGE--------ENGAHEIN-NHSKPMEIDGDV---EIPPNKATVLR- 176

Query: 366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLT---------------AVYTSPG 410
            GH   +F C + P   +LLA+ S D T ++W++N  +                 +  P 
Sbjct: 177 -GHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234

Query: 411 NEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSK 470
           N+ V  SL W   G   +A G+    A IW  + G +     +H    IF + W+ K + 
Sbjct: 235 NKDVT-SLDWNSDG-TLLAMGSYDGFARIWT-ENGNLASTLGQH-KGPIFALKWNKKGNY 290

Query: 471 RIATCSSDGFCIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVAT 529
            ++        I     G+   ++  H A     DW  N   M    C  T++ ++    
Sbjct: 291 VLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNN---MTFASCS-TDMCIHVCRL 346

Query: 530 SSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVR 589
             D P+K F GHT +V  +KW P    +L S SDD T++IW   QDAC++ L  H+  + 
Sbjct: 347 GCDHPVKTFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQDACVHDLQAHSKEIY 405

Query: 590 GLMW--------NTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP 641
            + W        N     +L S S+D T+++WD  +G C  T+  H   VY +   P   
Sbjct: 406 TIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGK 465

Query: 642 FTMASCSRDSTVRLWS 657
           + +AS S D  V +W+
Sbjct: 466 Y-LASGSFDKYVHIWN 480



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 69/266 (25%), Positives = 121/266 (45%), Gaps = 35/266 (13%)

Query: 381 DPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIW 440
           D  LLA  S+DG  ++W  N   A  T   ++G I++L W   G   ++ G  +    IW
Sbjct: 246 DGTLLAMGSYDGFARIWTENGNLAS-TLGQHKGPIFALKWNKKGNYVLSAGVDKT-TIIW 303

Query: 441 NVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCI----------IRTIDGKV 490
           +   G+  Q+F  H    +  + W  +++   A+CS+D  CI          ++T  G  
Sbjct: 304 DAHTGEAKQQFPFHSAPALD-VDW--QNNMTFASCSTD-MCIHVCRLGCDHPVKTFQG-- 357

Query: 491 LHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKW 550
                H   V    W  +   ++A+  +D  ++++  +   D  +     H+ +++ +KW
Sbjct: 358 -----HTNEVNAIKWDPSGM-LLASCSDDMTLKIW--SMKQDACVHDLQAHSKEIYTIKW 409

Query: 551 SPLREG--------ILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLI 602
           SP            +L S S D TVR+WD  Q  C + L  H  PV  + ++ +  YL  
Sbjct: 410 SPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLA- 468

Query: 603 SGSWDYTIKVWDTREGTCVDTVYDHG 628
           SGS+D  + +W+T+ G+ V +    G
Sbjct: 469 SGSFDKYVHIWNTQSGSLVHSYQGTG 494



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 68/271 (25%), Positives = 114/271 (42%), Gaps = 30/271 (11%)

Query: 410 GNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQK---GKIIQRFNEH----------GT 456
           G+E  ++  +W P   + +A G+  + A IWN+ +   G   Q    H            
Sbjct: 177 GHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235

Query: 457 NGIFCIAWSHKDSKRIATCSSDGFCIIRTIDGKVLHKY-KHPAAVFGCDWSQNNKDMIAT 515
             +  + W+  D   +A  S DGF  I T +G +     +H   +F   W++    +++ 
Sbjct: 236 KDVTSLDWN-SDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSA 294

Query: 516 GCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQD 575
           G + T + ++   T   +  + F  H+A    V W         S S D  + +     D
Sbjct: 295 GVDKTTI-IWDAHTGEAK--QQFPFHSAPALDVDWQ--NNMTFASCSTDMCIHVCRLGCD 349

Query: 576 ACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLT 635
             +    GHT  V  + W+     LL S S D T+K+W  ++  CV  +  H  ++Y + 
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIK 408

Query: 636 CHPSRPFT--------MASCSRDSTVRLWSL 658
             P+ P T        +AS S DSTVRLW +
Sbjct: 409 WSPTGPATSNPNSSIMLASASFDSTVRLWDV 439



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 41/144 (28%), Positives = 70/144 (48%), Gaps = 17/144 (11%)

Query: 354 DMGAKKWDFLRDL------GHVETIFDCKFKPDDPN--------LLATASFDGTIKVWDI 399
           DM  K W   +D        H + I+  K+ P  P         +LA+ASFD T+++WD+
Sbjct: 380 DMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDV 439

Query: 400 NTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGI 459
                 +T   ++  +YS++++P G   +A G+      IWN Q G ++  +   GT GI
Sbjct: 440 EQGVCTHTLMKHQEPVYSVAFSPDG-KYLASGSFDKYVHIWNTQSGSLVHSY--QGTGGI 496

Query: 460 FCIAWSHKDSKRIATCSSDGFCII 483
           F + W+ +  K  A+ S    C++
Sbjct: 497 FEVCWNARGDKVGASASDGSVCVL 520



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 90/398 (22%), Positives = 155/398 (38%), Gaps = 93/398 (23%)

Query: 54  IMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAE-------QKVIAKLDSTKG--I 104
           ++  H+  +   +W P + DL ASGS D+   IWN+ E       Q V+       G  +
Sbjct: 174 VLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232

Query: 105 PAS---LSWCWNAE-DVVAFVSHRGPLFIWTISGPDSGVI-VHKDAHSFLSDICMFRWHT 159
           P++    S  WN++  ++A  S+ G   IWT +G  +  +  HK        I   +W  
Sbjct: 233 PSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHK------GPIFALKW-- 284

Query: 160 HQKGK-VVFGHIDGSLSIF--HPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLL 216
           ++KG  V+   +D +  I+  H G   Q+           D ++ +T   +   STD  +
Sbjct: 285 NKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMT---FASCSTDMCI 341

Query: 217 VVNLHYGIRLVDSESLSC---ITTFNLPSAAASVQCLAWVPSAPGMFITGDSQVGVLRIW 273
            V             L C   + TF        V  + W PS  GM +   S    L+IW
Sbjct: 342 HVC-----------RLGCDHPVKTFQ--GHTNEVNAIKWDPS--GMLLASCSDDMTLKIW 386

Query: 274 NVSRTTPIDNLKLKKTGFHCLHVLNSPPRKKFSVQ-SPTKNHYTSSTSEAVPPPTLTQNQ 332
           ++ +               C+H L +  ++ ++++ SPT             P T   N 
Sbjct: 387 SMKQDA-------------CVHDLQAHSKEIYTIKWSPT------------GPATSNPNS 421

Query: 333 AFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD------LGHVETIFDCKFKPDDPNLLA 386
           +  L                +D   + WD  +       + H E ++   F PD    LA
Sbjct: 422 SIMLASAS------------FDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDG-KYLA 468

Query: 387 TASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGG 424
           + SFD  + +W+  + + V++  G  G I+ + W   G
Sbjct: 469 SGSFDKYVHIWNTQSGSLVHSYQGTGG-IFEVCWNARG 505


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score =  120 bits (302), Expect = 6e-27
 Identities = 100/376 (26%), Positives = 162/376 (43%), Gaps = 48/376 (12%)

Query: 306 SVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD 365
           S Q   KN   ++  E        +N A ++   H     +DG V   ++   K   LR 
Sbjct: 119 SQQGSAKNGENTANGE--------ENGAHTIANNHTDMMEVDGDV---EIPPNKAVVLR- 166

Query: 366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTS---------------PG 410
            GH   +F C + P   +LLA+ S D T ++W+++  +   ++               P 
Sbjct: 167 -GHESEVFICAWNPVS-DLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224

Query: 411 NEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSK 470
           N+ V  SL W   G   +A G+    A IW  + G +     +H    IF + W+ K + 
Sbjct: 225 NKDVT-SLDWNSEG-TLLATGSYDGFARIWT-KDGNLASTLGQH-KGPIFALKWNKKGNF 280

Query: 471 RIATCSSDGFCIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVAT 529
            ++        I     G+   ++  H A     DW  NN       C  T++ ++    
Sbjct: 281 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT---FASCS-TDMCIHVCKL 336

Query: 530 SSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVR 589
             D+P+K F GHT +V  +KW P    +L S SDD T++IW   QD C++ L  H   + 
Sbjct: 337 GQDRPIKTFQGHTNEVNAIKWDPTGN-LLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIY 395

Query: 590 GLMWNTEIP--------YLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP 641
            + W+   P         +L S S+D T+++WD   G C+ T+  H   VY +   P   
Sbjct: 396 TIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGR 455

Query: 642 FTMASCSRDSTVRLWS 657
           + +AS S D  V +W+
Sbjct: 456 Y-LASGSFDKCVHIWN 470



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 69/256 (26%), Positives = 118/256 (46%), Gaps = 35/256 (13%)

Query: 384 LLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQ 443
           LLAT S+DG  ++W  +   A  T   ++G I++L W   G   ++ G  +    IW+  
Sbjct: 239 LLATGSYDGFARIWTKDGNLAS-TLGQHKGPIFALKWNKKGNFILSAGVDKT-TIIWDAH 296

Query: 444 KGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCI----------IRTIDGKVLHK 493
            G+  Q+F  H    +  + W   ++   A+CS+D  CI          I+T  G     
Sbjct: 297 TGEAKQQFPFHSAPALD-VDWQSNNT--FASCSTD-MCIHVCKLGQDRPIKTFQG----- 347

Query: 494 YKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPL 553
             H   V    W     +++A+  +D  ++++  +   D  +     H  +++ +KWSP 
Sbjct: 348 --HTNEVNAIKWDPTG-NLLASCSDDMTLKIW--SMKQDNCVHDLQAHNKEIYTIKWSPT 402

Query: 554 REG--------ILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGS 605
             G        +L S S D TVR+WD  +  CI+ L  H  PV  + ++ +  YL  SGS
Sbjct: 403 GPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLA-SGS 461

Query: 606 WDYTIKVWDTREGTCV 621
           +D  + +W+T+ G  V
Sbjct: 462 FDKCVHIWNTQTGALV 477



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 41/144 (28%), Positives = 71/144 (49%), Gaps = 17/144 (11%)

Query: 354 DMGAKKWDFLRD------LGHVETIFDCKFKPDDPN--------LLATASFDGTIKVWDI 399
           DM  K W   +D        H + I+  K+ P  P         +LA+ASFD T+++WD+
Sbjct: 370 DMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDV 429

Query: 400 NTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGI 459
           +    ++T   ++  +YS++++P G   +A G+      IWN Q G ++  +   GT GI
Sbjct: 430 DRGICIHTLTKHQEPVYSVAFSPDG-RYLASGSFDKCVHIWNTQTGALVHSY--RGTGGI 486

Query: 460 FCIAWSHKDSKRIATCSSDGFCII 483
           F + W+    K  A+ S    C++
Sbjct: 487 FEVCWNAAGDKVGASASDGSVCVL 510



 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 73/283 (25%), Positives = 116/283 (40%), Gaps = 27/283 (9%)

Query: 351 GLYDMGAKKW----DFLRDLG-HVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAV 405
           G YD  A+ W    +    LG H   IF  K+     N + +A  D T  +WD +T  A 
Sbjct: 243 GSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKG-NFILSAGVDKTTIIWDAHTGEAK 301

Query: 406 YTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWS 465
              P +      + W     N  A  ++     +  + + + I+ F  H TN +  I W 
Sbjct: 302 QQFPFHSAPALDVDWQSN--NTFASCSTDMCIHVCKLGQDRPIKTFQGH-TNEVNAIKWD 358

Query: 466 HKDSKRIATCSSDGFCIIRTI--DGKVLHKYKHPAAVFGCDWSQ-----NNKD---MIAT 515
                 +A+CS D    I ++  D  V     H   ++   WS      NN +   M+A+
Sbjct: 359 -PTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLAS 417

Query: 516 GCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREG-ILCSGSDDGTVRIWDYTQ 574
              D+ VR++ V       +   + H   V+ V +SP  +G  L SGS D  V IW+   
Sbjct: 418 ASFDSTVRLWDVDRGIC--IHTLTKHQEPVYSVAFSP--DGRYLASGSFDKCVHIWNTQT 473

Query: 575 DACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRE 617
            A ++   G T  +  + WN     +  S S D ++ V D R+
Sbjct: 474 GALVHSYRG-TGGIFEVCWNAAGDKVGASAS-DGSVCVLDLRK 514



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 89/394 (22%), Positives = 146/394 (37%), Gaps = 85/394 (21%)

Query: 54  IMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKL---------DSTKGI 104
           ++  H+  +   +W P + DL ASGS D+   IWN++E                +  + +
Sbjct: 164 VLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDV 222

Query: 105 PAS---LSWCWNAE-DVVAFVSHRGPLFIWTISGPDSGVI-VHKDAHSFLSDICMFRWHT 159
           P++    S  WN+E  ++A  S+ G   IWT  G  +  +  HK        I   +W  
Sbjct: 223 PSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHK------GPIFALKW-- 274

Query: 160 HQKGK-VVFGHIDGSLSIF--HPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLL 216
           ++KG  ++   +D +  I+  H G   Q+                  AL+ D  S +   
Sbjct: 275 NKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFH-----------SAPALDVDWQSNNTFA 323

Query: 217 VVNLHYGIRLVDSESLSCITTFNLPSAAASVQCLAWVPSAPGMFITGDSQVGVLRIWNVS 276
             +    I +        I TF        V  + W P+  G  +   S    L+IW++ 
Sbjct: 324 SCSTDMCIHVCKLGQDRPIKTFQ--GHTNEVNAIKWDPT--GNLLASCSDDMTLKIWSMK 379

Query: 277 RTTPIDNLKLKKTGFHCLHVLNSPPRKKFSVQSPTKNHYTSSTSEAVPPPTLTQNQAFSL 336
           +    DN         C+H           +Q+  K  YT   S   P    T N   +L
Sbjct: 380 Q----DN---------CVH----------DLQAHNKEIYTIKWSPTGPG---TNNPNANL 413

Query: 337 PPGHAVCCFLDGGVGLYDMGAKKWDFLRDL------GHVETIFDCKFKPDDPNLLATASF 390
               A           +D   + WD  R +       H E ++   F PD    LA+ SF
Sbjct: 414 MLASA----------SFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDG-RYLASGSF 462

Query: 391 DGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGG 424
           D  + +W+  T   V++  G  G I+ + W   G
Sbjct: 463 DKCVHIWNTQTGALVHSYRGTGG-IFEVCWNAAG 495


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score =  107 bits (266), Expect = 1e-22
 Identities = 78/277 (28%), Positives = 128/277 (46%), Gaps = 18/277 (6%)

Query: 383 NLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNV 442
           N + + S D T+KVW   T   + T  G+ G ++S        N I  G++     +WN 
Sbjct: 274 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRD---NIIISGSTDRTLKVWNA 330

Query: 443 QKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCIIRTID-GKVLHKYKHPAAVF 501
           + G+ I     H T+ + C+   H   KR+ + S D    +  I+ G+ LH      A  
Sbjct: 331 ETGECIHTLYGH-TSTVRCM---HLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAV 386

Query: 502 GCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSG 561
            C   Q +   + +G  D  V+V+   T +   L    GHT +V+ +++  +    + SG
Sbjct: 387 RC--VQYDGRRVVSGAYDFMVKVWDPETETC--LHTLQGHTNRVYSLQFDGIH---VVSG 439

Query: 562 SDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCV 621
           S D ++R+WD     CI+ L GH +   G+     I   L+SG+ D T+K+WD + G C+
Sbjct: 440 SLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI---LVSGNADSTVKIWDIKTGQCL 496

Query: 622 DTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 658
            T+         +TC       + + S D TV+LW L
Sbjct: 497 QTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDL 533



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 47/229 (20%), Positives = 91/229 (39%), Gaps = 54/229 (23%)

Query: 366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGL 425
           +GHV  +   ++   D   + + ++D  +KVWD  T T ++T  G+   +YSL +   G+
Sbjct: 380 MGHVAAVRCVQY---DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGI 434

Query: 426 NCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCIIRT 485
           + ++G        +W+V+ G                                     I T
Sbjct: 435 HVVSGSLD-TSIRVWDVETGN-----------------------------------CIHT 458

Query: 486 IDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKV 545
           + G       H +   G +   N   ++ +G  D+ V+++ + T   Q L+   G     
Sbjct: 459 LTG-------HQSLTSGMELKDN---ILVSGNADSTVKIWDIKTG--QCLQTLQGPNKHQ 506

Query: 546 FHVKWSPLREGILCSGSDDGTVRIWDY-TQDACINILNGHTAPVRGLMW 593
             V      +  + + SDDGTV++WD  T +   N++   +    G++W
Sbjct: 507 SAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVW 555



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 87/403 (21%), Positives = 152/403 (37%), Gaps = 88/403 (21%)

Query: 45  RYNEFKLHAIMSEHKK-TITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKL-DSTK 102
           R  E K   ++  H    IT + +C +      SGS DN + +W+    K +  L   T 
Sbjct: 248 RRGELKSPKVLKGHDDHVITCLQFCGNR---IVSGSDDNTLKVWSAVTGKCLRTLVGHTG 304

Query: 103 GIPASLSWCWNAEDVVAFVSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQK 162
           G+ +S       ++++   S    L +W     ++G  +H       +  CM   H H+K
Sbjct: 305 GVWSSQM----RDNIIISGSTDRTLKVW---NAETGECIHTLYGHTSTVRCM---HLHEK 354

Query: 163 GKVVFGHIDGSLSIFHPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLLVVNLHY 222
            +VV G  D +L ++        HVL             V A+         ++     +
Sbjct: 355 -RVVSGSRDATLRVWDIETGQCLHVLMGH----------VAAVRCVQYDGRRVVSGAYDF 403

Query: 223 GIRLVDSESLSCITTFNLPSAAASVQCLAWVPSAPGMFITGDSQVGVLRIWNVSRTTPID 282
            +++ D E+ +C+ T  L      V  L +     G+ +   S    +R+W+V       
Sbjct: 404 MVKVWDPETETCLHT--LQGHTNRVYSLQF----DGIHVVSGSLDTSIRVWDV------- 450

Query: 283 NLKLKKTGFHCLHVLNSPPRKKFSVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAV 342
                +TG +C+H L                H + ++   +    L    A         
Sbjct: 451 -----ETG-NCIHTLT--------------GHQSLTSGMELKDNILVSGNA--------- 481

Query: 343 CCFLDGGVGLYDMGAKKWDFLRDL----GHVETIFDCKFKPDDPNLLATASFDGTIKVWD 398
               D  V ++D+  K    L+ L     H   +   +F   + N + T+S DGT+K+WD
Sbjct: 482 ----DSTVKIWDI--KTGQCLQTLQGPNKHQSAVTCLQF---NKNFVITSSDDGTVKLWD 532

Query: 399 INT-----LTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNG 436
           + T           S G+ GV++ +  +   L C  G  SRNG
Sbjct: 533 LKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVG--SRNG 573


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score =  107 bits (266), Expect = 1e-22
 Identities = 78/277 (28%), Positives = 128/277 (46%), Gaps = 18/277 (6%)

Query: 383 NLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNV 442
           N + + S D T+KVW   T   + T  G+ G ++S        N I  G++     +WN 
Sbjct: 392 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRD---NIIISGSTDRTLKVWNA 448

Query: 443 QKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCIIRTID-GKVLHKYKHPAAVF 501
           + G+ I     H T+ + C+   H   KR+ + S D    +  I+ G+ LH      A  
Sbjct: 449 ETGECIHTLYGH-TSTVRCM---HLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAV 504

Query: 502 GCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSG 561
            C   Q +   + +G  D  V+V+   T +   L    GHT +V+ +++  +    + SG
Sbjct: 505 RC--VQYDGRRVVSGAYDFMVKVWDPETETC--LHTLQGHTNRVYSLQFDGIH---VVSG 557

Query: 562 SDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCV 621
           S D ++R+WD     CI+ L GH +   G+     I   L+SG+ D T+K+WD + G C+
Sbjct: 558 SLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI---LVSGNADSTVKIWDIKTGQCL 614

Query: 622 DTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 658
            T+         +TC       + + S D TV+LW L
Sbjct: 615 QTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDL 651



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 47/229 (20%), Positives = 91/229 (39%), Gaps = 54/229 (23%)

Query: 366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGL 425
           +GHV  +   ++   D   + + ++D  +KVWD  T T ++T  G+   +YSL +   G+
Sbjct: 498 MGHVAAVRCVQY---DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGI 552

Query: 426 NCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCIIRT 485
           + ++G        +W+V+ G                                     I T
Sbjct: 553 HVVSGSLD-TSIRVWDVETGN-----------------------------------CIHT 576

Query: 486 IDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKV 545
           + G       H +   G +   N   ++ +G  D+ V+++ + T   Q L+   G     
Sbjct: 577 LTG-------HQSLTSGMELKDN---ILVSGNADSTVKIWDIKTG--QCLQTLQGPNKHQ 624

Query: 546 FHVKWSPLREGILCSGSDDGTVRIWDY-TQDACINILNGHTAPVRGLMW 593
             V      +  + + SDDGTV++WD  T +   N++   +    G++W
Sbjct: 625 SAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVW 673



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 87/403 (21%), Positives = 152/403 (37%), Gaps = 88/403 (21%)

Query: 45  RYNEFKLHAIMSEHKK-TITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKL-DSTK 102
           R  E K   ++  H    IT + +C +      SGS DN + +W+    K +  L   T 
Sbjct: 366 RRGELKSPKVLKGHDDHVITCLQFCGNR---IVSGSDDNTLKVWSAVTGKCLRTLVGHTG 422

Query: 103 GIPASLSWCWNAEDVVAFVSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQK 162
           G+ +S       ++++   S    L +W     ++G  +H       +  CM   H H+K
Sbjct: 423 GVWSSQM----RDNIIISGSTDRTLKVW---NAETGECIHTLYGHTSTVRCM---HLHEK 472

Query: 163 GKVVFGHIDGSLSIFHPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLLVVNLHY 222
            +VV G  D +L ++        HVL             V A+         ++     +
Sbjct: 473 -RVVSGSRDATLRVWDIETGQCLHVLMGH----------VAAVRCVQYDGRRVVSGAYDF 521

Query: 223 GIRLVDSESLSCITTFNLPSAAASVQCLAWVPSAPGMFITGDSQVGVLRIWNVSRTTPID 282
            +++ D E+ +C+ T  L      V  L +     G+ +   S    +R+W+V       
Sbjct: 522 MVKVWDPETETCLHT--LQGHTNRVYSLQF----DGIHVVSGSLDTSIRVWDV------- 568

Query: 283 NLKLKKTGFHCLHVLNSPPRKKFSVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAV 342
                +TG +C+H L                H + ++   +    L    A         
Sbjct: 569 -----ETG-NCIHTLT--------------GHQSLTSGMELKDNILVSGNA--------- 599

Query: 343 CCFLDGGVGLYDMGAKKWDFLRDL----GHVETIFDCKFKPDDPNLLATASFDGTIKVWD 398
               D  V ++D+  K    L+ L     H   +   +F   + N + T+S DGT+K+WD
Sbjct: 600 ----DSTVKIWDI--KTGQCLQTLQGPNKHQSAVTCLQF---NKNFVITSSDDGTVKLWD 650

Query: 399 INT-----LTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNG 436
           + T           S G+ GV++ +  +   L C  G  SRNG
Sbjct: 651 LKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVG--SRNG 691


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score =  107 bits (266), Expect = 1e-22
 Identities = 78/277 (28%), Positives = 128/277 (46%), Gaps = 18/277 (6%)

Query: 383 NLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNV 442
           N + + S D T+KVW   T   + T  G+ G ++S        N I  G++     +WN 
Sbjct: 312 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRD---NIIISGSTDRTLKVWNA 368

Query: 443 QKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCIIRTID-GKVLHKYKHPAAVF 501
           + G+ I     H T+ + C+   H   KR+ + S D    +  I+ G+ LH      A  
Sbjct: 369 ETGECIHTLYGH-TSTVRCM---HLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAV 424

Query: 502 GCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSG 561
            C   Q +   + +G  D  V+V+   T +   L    GHT +V+ +++  +    + SG
Sbjct: 425 RC--VQYDGRRVVSGAYDFMVKVWDPETETC--LHTLQGHTNRVYSLQFDGIH---VVSG 477

Query: 562 SDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCV 621
           S D ++R+WD     CI+ L GH +   G+     I   L+SG+ D T+K+WD + G C+
Sbjct: 478 SLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI---LVSGNADSTVKIWDIKTGQCL 534

Query: 622 DTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 658
            T+         +TC       + + S D TV+LW L
Sbjct: 535 QTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDL 571



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 47/229 (20%), Positives = 91/229 (39%), Gaps = 54/229 (23%)

Query: 366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGL 425
           +GHV  +   ++   D   + + ++D  +KVWD  T T ++T  G+   +YSL +   G+
Sbjct: 418 MGHVAAVRCVQY---DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGI 472

Query: 426 NCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCIIRT 485
           + ++G        +W+V+ G                                     I T
Sbjct: 473 HVVSGSLD-TSIRVWDVETGN-----------------------------------CIHT 496

Query: 486 IDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKV 545
           + G       H +   G +   N   ++ +G  D+ V+++ + T   Q L+   G     
Sbjct: 497 LTG-------HQSLTSGMELKDN---ILVSGNADSTVKIWDIKTG--QCLQTLQGPNKHQ 544

Query: 546 FHVKWSPLREGILCSGSDDGTVRIWDY-TQDACINILNGHTAPVRGLMW 593
             V      +  + + SDDGTV++WD  T +   N++   +    G++W
Sbjct: 545 SAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVW 593



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 87/403 (21%), Positives = 152/403 (37%), Gaps = 88/403 (21%)

Query: 45  RYNEFKLHAIMSEHKK-TITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKL-DSTK 102
           R  E K   ++  H    IT + +C +      SGS DN + +W+    K +  L   T 
Sbjct: 286 RRGELKSPKVLKGHDDHVITCLQFCGNR---IVSGSDDNTLKVWSAVTGKCLRTLVGHTG 342

Query: 103 GIPASLSWCWNAEDVVAFVSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQK 162
           G+ +S       ++++   S    L +W     ++G  +H       +  CM   H H+K
Sbjct: 343 GVWSSQM----RDNIIISGSTDRTLKVW---NAETGECIHTLYGHTSTVRCM---HLHEK 392

Query: 163 GKVVFGHIDGSLSIFHPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLLVVNLHY 222
            +VV G  D +L ++        HVL             V A+         ++     +
Sbjct: 393 -RVVSGSRDATLRVWDIETGQCLHVLMGH----------VAAVRCVQYDGRRVVSGAYDF 441

Query: 223 GIRLVDSESLSCITTFNLPSAAASVQCLAWVPSAPGMFITGDSQVGVLRIWNVSRTTPID 282
            +++ D E+ +C+ T  L      V  L +     G+ +   S    +R+W+V       
Sbjct: 442 MVKVWDPETETCLHT--LQGHTNRVYSLQF----DGIHVVSGSLDTSIRVWDV------- 488

Query: 283 NLKLKKTGFHCLHVLNSPPRKKFSVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAV 342
                +TG +C+H L                H + ++   +    L    A         
Sbjct: 489 -----ETG-NCIHTLT--------------GHQSLTSGMELKDNILVSGNA--------- 519

Query: 343 CCFLDGGVGLYDMGAKKWDFLRDL----GHVETIFDCKFKPDDPNLLATASFDGTIKVWD 398
               D  V ++D+  K    L+ L     H   +   +F   + N + T+S DGT+K+WD
Sbjct: 520 ----DSTVKIWDI--KTGQCLQTLQGPNKHQSAVTCLQF---NKNFVITSSDDGTVKLWD 570

Query: 399 INT-----LTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNG 436
           + T           S G+ GV++ +  +   L C  G  SRNG
Sbjct: 571 LKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVG--SRNG 611


>gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
          Length = 323

 Score =  100 bits (248), Expect = 1e-20
 Identities = 70/250 (28%), Positives = 120/250 (48%), Gaps = 11/250 (4%)

Query: 372 IFDCKFKPDDPNLLATASFDGTIKVWDINTLTA---VYTSPGNEGVIYSLSWAPG-GLNC 427
           +FD  +  ++ ++L T S DG++++WD         VY     E  +YS+ W+   G   
Sbjct: 70  LFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQE--VYSVDWSQTRGEQL 127

Query: 428 IAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCIIRTID 487
           +  G+      +W+   GK +  F  H +  I+   WS       A+ S D    I  + 
Sbjct: 128 VVSGSWDQTVKLWDPTVGKSLCTFRGHESI-IYSTIWSPHIPGCFASASGDQTLRIWDVK 186

Query: 488 --GKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKV 545
             G  +    H A +  CDW + N++++ TG  D ++R + +     QP+    GHT  +
Sbjct: 187 AAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVR-QPVFELLGHTYAI 245

Query: 546 FHVKWSPLREGILCSGSDDGTVRIWDYTQ-DACINILNGHTAPVRGLMWNTEIPYLLISG 604
             VK+SP    +L S S D TVR W++++ D+ +  +  HT    GL ++ + P  +   
Sbjct: 246 RRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADC 305

Query: 605 SWDYTIKVWD 614
           SWD TIK++D
Sbjct: 306 SWDETIKIYD 315



 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 80/303 (26%), Positives = 122/303 (40%), Gaps = 36/303 (11%)

Query: 408 SPGNEGVIYSLS-WAPGGLNCIAG---GTSRNGAFIWNVQKGKIIQRFNEHGTN-GIFCI 462
           +PG  G     S + PG L C      G +  G  +        ++ F     N G+F +
Sbjct: 14  TPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSFDWNDGLFDV 73

Query: 463 AWSHKDSKRIATCSSDGFCIIRTIDGKV--LHKYK-HPAAVFGCDWSQNN-KDMIATGCE 518
            WS  +   + TCS DG   +         L  YK H   V+  DWSQ   + ++ +G  
Sbjct: 74  TWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSW 133

Query: 519 DTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACI 578
           D  V+++         L  F GH + ++   WSP   G   S S D T+RIWD       
Sbjct: 134 DQTVKLWDPTVGKS--LCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVR 191

Query: 579 NILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRE-GTCVDTVYDHGADVYGLTCH 637
            ++  H A +    W      LL++G+ D +++ WD R     V  +  H   +  +   
Sbjct: 192 IVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFS 251

Query: 638 PSRPFTMASCSRDSTVRLWSLT---------------------ALVTPVQINILADRSWE 676
           P     +ASCS D TVR W+ +                     +L +P Q+   AD SW+
Sbjct: 252 PFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQV---ADCSWD 308

Query: 677 EII 679
           E I
Sbjct: 309 ETI 311



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 50/175 (28%), Positives = 83/175 (47%), Gaps = 8/175 (4%)

Query: 545 VFHVKWSPLREGILCSGSDDGTVRIWDYTQDAC-INILNGHTAPVRGLMWN-TEIPYLLI 602
           +F V WS   E +L + S DG++++WD  + A  + +   H   V  + W+ T    L++
Sbjct: 70  LFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVV 129

Query: 603 SGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTA-- 660
           SGSWD T+K+WD   G  + T   H + +Y     P  P   AS S D T+R+W + A  
Sbjct: 130 SGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAG 189

Query: 661 --LVTPVQINILADRSWEEIIGNTDYAIEPGTPPLLCGKVSRDIRQEIEKLTANS 713
             +V P     +    W +   N +  +       L G   R++RQ + +L  ++
Sbjct: 190 VRIVIPAHQAEILSCDWCKY--NENLLVTGAVDCSLRGWDLRNVRQPVFELLGHT 242



 Score = 37.4 bits (85), Expect = 0.094
 Identities = 19/61 (31%), Positives = 29/61 (47%)

Query: 58  HKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDV 117
           H+  I +  W PH P  FAS S D  + IW+V    V   + + +    S  WC   E++
Sbjct: 154 HESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENL 213

Query: 118 V 118
           +
Sbjct: 214 L 214



 Score = 37.0 bits (84), Expect = 0.12
 Identities = 30/122 (24%), Positives = 49/122 (40%), Gaps = 5/122 (4%)

Query: 54  IMSEHKKTITAISWCP-HNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCW 112
           +  EH + + ++ W       L  SGS D  V +W+    K +      + I  S  W  
Sbjct: 106 VYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSP 165

Query: 113 NAEDVVAFVSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGHIDG 172
           +     A  S    L IW +    +GV +   AH   ++I    W  + +  +V G +D 
Sbjct: 166 HIPGCFASASGDQTLRIWDVKA--AGVRIVIPAHQ--AEILSCDWCKYNENLLVTGAVDC 221

Query: 173 SL 174
           SL
Sbjct: 222 SL 223



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 23/86 (26%), Positives = 39/86 (45%), Gaps = 3/86 (3%)

Query: 54  IMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNV--AEQKVIAKLDSTKGIPASLSWC 111
           ++  H+  I +  WC +N +L  +G+ D  +  W++    Q V   L  T  I       
Sbjct: 193 VIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSP 252

Query: 112 WNAEDVVAFVSHRGPLFIWTISGPDS 137
           ++A  V+A  S+   +  W  S PDS
Sbjct: 253 FHA-SVLASCSYDFTVRFWNFSKPDS 277


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 81/325 (24%), Positives = 145/325 (44%), Gaps = 28/325 (8%)

Query: 344 CFLDGGVGLYDMGAKKWDF-----LRDL-GHVETIFDCKFKPDDPNLLATASFDGTIKVW 397
           CF+ G    YD   K WD      L  L GH   ++   F     + +AT SFD T K+W
Sbjct: 106 CFITGS---YDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW 162

Query: 398 DINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTN 457
            + T    +T  G+   I  LS+ P     +A G+    A +W++Q G+ +     H   
Sbjct: 163 SVETGKCYHTFRGHTAEIVCLSFNPQS-TLVATGSMDTTAKLWDIQNGEEVYTLRGHSAE 221

Query: 458 GIFCIAWSHKDSKRIATCSSDGFCII------RTIDGKVLHKYKHPAAVFGCDWSQNNKD 511
            I  +++ +    RI T S D   ++      R ++  + H  +  +A F  D S     
Sbjct: 222 -IISLSF-NTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS----- 274

Query: 512 MIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWD 571
           +I TG  D   +++    ++ + +   +GH  ++    +    + ++ + S DGT RI+ 
Sbjct: 275 LILTGSMDKTCKLW--DATNGKCVATLTGHDDEILDSCFDYTGK-LIATASADGTARIFS 331

Query: 572 YTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADV 631
                CI  L GH   +  + +N +  +LL +GS D T ++WD + G C+  +  H  ++
Sbjct: 332 AATRKCIAKLEGHEGEISKISFNPQGNHLL-TGSSDKTARIWDAQTGQCLQVLEGHTDEI 390

Query: 632 YGLTCHPSRPFTMASCSRDSTVRLW 656
           +    +      +   S+D+T R+W
Sbjct: 391 FSCAFNYKGNIVITG-SKDNTCRIW 414



 Score = 88.2 bits (217), Expect = 5e-17
 Identities = 80/289 (27%), Positives = 119/289 (41%), Gaps = 23/289 (7%)

Query: 333 AFSLPPGHAVCCFLDGGVGLYDMGAKKWD------FLRDLGHVETIFDCKFKPDDPNLLA 386
           AF+ P G  +        G +D   K W       +    GH   I    F P    L+A
Sbjct: 141 AFNNPYGDKIA------TGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQS-TLVA 193

Query: 387 TASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGK 446
           T S D T K+WDI     VYT  G+   I SLS+   G   I G        +W+   G+
Sbjct: 194 TGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHT-VVVWDADTGR 252

Query: 447 IIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFC-IIRTIDGK-VLHKYKHPAAVFGCD 504
            +     H        A  + D   I T S D  C +    +GK V     H   +    
Sbjct: 253 KVNILIGHCAE--ISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310

Query: 505 WSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDD 564
           +    K +IAT   D   R++  AT   + +    GH  ++  + ++P    +L +GS D
Sbjct: 311 FDYTGK-LIATASADGTARIFSAATR--KCIAKLEGHEGEISKISFNPQGNHLL-TGSSD 366

Query: 565 GTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVW 613
            T RIWD     C+ +L GHT  +    +N +   ++I+GS D T ++W
Sbjct: 367 KTARIWDAQTGQCLQVLEGHTDEIFSCAFNYK-GNIVITGSKDNTCRIW 414



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 31/99 (31%), Positives = 50/99 (50%), Gaps = 1/99 (1%)

Query: 560 SGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGT 619
           +GS D T ++WD      +N L GH   V  + +N      + +GS+D T K+W    G 
Sbjct: 109 TGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK 168

Query: 620 CVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 658
           C  T   H A++  L+ +P     +A+ S D+T +LW +
Sbjct: 169 CYHTFRGHTAEIVCLSFNPQSTL-VATGSMDTTAKLWDI 206



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 25/79 (31%), Positives = 40/79 (50%), Gaps = 1/79 (1%)

Query: 580 ILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPS 639
           +L  H  P+  +  N       I+GS+D T K+WDT  G  ++T+  H   VY +  +  
Sbjct: 87  VLKAHILPLTNVALNKS-GSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145

Query: 640 RPFTMASCSRDSTVRLWSL 658
               +A+ S D T +LWS+
Sbjct: 146 YGDKIATGSFDKTCKLWSV 164


>gi|157739942 gemin 5 [Homo sapiens]
          Length = 1508

 Score = 95.1 bits (235), Expect = 4e-19
 Identities = 212/1058 (20%), Positives = 376/1058 (35%), Gaps = 259/1058 (24%)

Query: 23   AASGDRFAYCATLAIYIYQLDHRYNE------FKLHAIMSEHKKTITAISWCPH--NPDL 74
            A  G  F + A  ++++ ++     E      F++   +  H + ++  ++  H    +L
Sbjct: 22   AVPGGLFGFAARTSVFLVRVGPGAGESPGTPPFRVIGELVGHTERVSGFTFSHHPGQYNL 81

Query: 75   FASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDVVAFVSHRGPLFIWTISG 134
             A+ S D  V IW+V  + V+ +    +   ++L W    +D++     +G +F +  + 
Sbjct: 82   CATSSDDGTVKIWDVETKTVVTEHALHQHTISTLHWSPRVKDLIVSGDEKGVVFCYWFNR 141

Query: 135  PDSGVIVHKDAHSFLSDICMF--RWHTHQKGKVVFGHIDGSLSIFHPGNKNQK-HVLRPE 191
             DS        H F+    +F      H +  V  G+ DG + I     K +  H LR  
Sbjct: 142  NDS-------QHLFIEPRTIFCLTCSPHHEDLVAIGYKDGIVVIIDISKKGEVIHRLR-- 192

Query: 192  SLEGTDEEDPVTALEWDPLSTDYLLVVNLHYGIRLVDSESLSCITTFNLPSAAASVQCLA 251
                   +D + ++ W PL  +  L +N        ++   + IT  N          +A
Sbjct: 193  -----GHDDEIHSIAWCPLPGEDCLSINQE------ETSEEAEITNGN---------AVA 232

Query: 252  WVPSAPGMFITGDSQVGVLRIWNVSRTTPIDNLKL--------------KKTGFHCLHVL 297
              P   G ++   S+   +RIW+ SR   +  LKL              K+  +  LH  
Sbjct: 233  QAPVTKGCYLATGSKDQTIRIWSCSRGRGVMILKLPFLKRRGGGIDPTVKERLWLTLHWP 292

Query: 298  NSPPRK-----------KFSVQSPTKNHYT--SSTSEAVPPPTLTQNQA---FSLPPGHA 341
            ++ P +           ++ +    +  YT  S++SE        QN +   F+L P   
Sbjct: 293  SNQPTQLVSSCFGGELLQWDLTQSWRRKYTLFSASSEG-------QNHSRIVFNLCPLQT 345

Query: 342  -------VCCFLDGGVGLYDMGAKKWDF-LRDLGHVETIFDCKFKPDDPNLLATASFDGT 393
                   +   +D  V  +D+   +  + L  LG     +   F   D   LA    DG 
Sbjct: 346  EDDKQLLLSTSMDRDVKCWDIATLECSWTLPSLGGFA--YSLAFSSVDIGSLAIGVGDGM 403

Query: 394  IKVWDINTLTAVYTSP----GNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQ 449
            I+VW+  ++   Y       G +  + +L W P    C+A GT      +++    K  Q
Sbjct: 404  IRVWNTLSIKNNYDVKNFWQGVKSKVTALCWHPTKEGCLAFGTDDGKVGLYDTYSNKPPQ 463

Query: 450  RFNEHGTNGIFCIAWS------------HKDSKRIATCSSDG--------------FCII 483
              + +    ++ +AW              + S  + +C  +G              F I 
Sbjct: 464  ISSTYHKKTVYTLAWGPPVPPMSLGGEGDRPSLALYSCGGEGIVLQHNPWKLSGEAFDIN 523

Query: 484  RTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRV------------------- 524
            + I      KYK P       W  + K M A G ED ++ +                   
Sbjct: 524  KLIRDTNSIKYKLPVHT-EISWKADGKIM-ALGNEDGSIEIFQIPNLKLICTIQQHHKLV 581

Query: 525  ----------------YYVATSSD------------------------QPLKVFSGHTAK 544
                            Y +A+ S+                        +P +  SGHTAK
Sbjct: 582  NTISWHHEHGSQPELSYLMASGSNNAVIYVHNLKTVIESSPESPVTITEPYRTLSGHTAK 641

Query: 545  VFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISG 604
            +  V WSP  +G L S S DGT ++WD  ++  +    GH   +  + W+   P  + SG
Sbjct: 642  ITSVAWSPHHDGRLVSASYDGTAQVWDALREEPLCNFRGHRGRLLCVAWSPLDPDCIYSG 701

Query: 605  SWDYTIKVWDTREGTCVDTVYDHGADVYGLTC------HPSRPFTMASCSRDSTVRLWSL 658
            + D+ +  W T       ++ DH     G           S+P       +  T+R    
Sbjct: 702  ADDFCVHKWLT-------SMQDHSRPPQGKKSIELEKKRLSQPKAKPKKKKKPTLR---- 750

Query: 659  TALVTPVQINILADRSWEEIIGNT-------------DYAIEPGTP----------PLLC 695
                TPV++  +     E +  N+             + A EP  P          P++C
Sbjct: 751  ----TPVKLESIDGNEEESMKENSGPVENGVSDQEGEEQAREPELPCGLAPAVSREPVIC 806

Query: 696  GKVSRDIRQEIEKLTANSQVKKLRWFSECLSPPGGSDNLWNLVAVIKGQDDSLLP----- 750
              VS     E  K+T N++V  L+       PP           + K +  SLLP     
Sbjct: 807  TPVSSGF--EKSKVTINNKVILLK-----KEPPKEKPE----TLIKKRKARSLLPLSTSL 855

Query: 751  QNYCKGIMHLKHLIKFRTSEAQELTTVKMSKFGG--GIGVPAKEERLKEAAEI----HLR 804
             +  K  +H   L+      ++EL     +       +G+      L    +I    HL 
Sbjct: 856  DHRSKEELHQDCLVLATAKHSRELNEDVSADVEERFHLGLFTDRATLYRMIDIEGKGHLE 915

Query: 805  LGQIQRYCELMVELGE--------------WDKALSIAPGVSVKYWKKLMQRRADQL-IQ 849
             G  + + +LM+  G+               D  +++AP      W   ++  A QL  Q
Sbjct: 916  NGHPELFHQLMLWKGDLKGVLQTAAERGELTDNLVAMAPAAGYHVWLWAVEAFAKQLCFQ 975

Query: 850  EDKDDVIPYCIAIGDVKKLVHFFMSRGQLKEALLVAQA 887
            +       + ++I  V + V    S    +EA+ +A+A
Sbjct: 976  DQYVKAASHLLSIHKVYEAVELLKSNHFYREAIAIAKA 1013



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 81/327 (24%), Positives = 131/327 (40%), Gaps = 46/327 (14%)

Query: 310 PTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRDL-GH 368
           P+ N Y +  S+AVP         F      +V     G       G   +  + +L GH
Sbjct: 10  PSPNWYCARCSDAVP------GGLFGFAARTSVFLVRVGPGAGESPGTPPFRVIGELVGH 63

Query: 369 VETI--FDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLN 426
            E +  F     P   NL AT+S DGT+K+WD+ T T V     ++  I +L W+P   +
Sbjct: 64  TERVSGFTFSHHPGQYNLCATSSDDGTVKIWDVETKTVVTEHALHQHTISTLHWSPRVKD 123

Query: 427 CIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCIIRTI 486
            I  G  +   F +   +      F E  T  IFC+  S      +A    DG  +I  I
Sbjct: 124 LIVSGDEKGVVFCYWFNRNDSQHLFIEPRT--IFCLTCSPHHEDLVAIGYKDGIVVIIDI 181

Query: 487 D--GKVLHKYK-HPAAVFGCDWSQ-NNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHT 542
              G+V+H+ + H   +    W     +D ++   E+T+           +  ++ +G+ 
Sbjct: 182 SKKGEVIHRLRGHDDEIHSIAWCPLPGEDCLSINQEETS-----------EEAEITNGNA 230

Query: 543 AKVFHVKWSPLREG-ILCSGSDDGTVRIWDYTQDACINILNGHTAPVRG----------- 590
                V  +P+ +G  L +GS D T+RIW  ++   + IL       RG           
Sbjct: 231 -----VAQAPVTKGCYLATGSKDQTIRIWSCSRGRGVMILKLPFLKRRGGGIDPTVKERL 285

Query: 591 ---LMWNTEIPYLLISGSWDYTIKVWD 614
              L W +  P  L+S  +   +  WD
Sbjct: 286 WLTLHWPSNQPTQLVSSCFGGELLQWD 312


>gi|4502477 beta-transducin repeat containing protein isoform 2
           [Homo sapiens]
          Length = 569

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 76/292 (26%), Positives = 131/292 (44%), Gaps = 39/292 (13%)

Query: 381 DPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIW 440
           D   + +   D TIK+WD NTL       G+ G +  L +       I  G+S +   +W
Sbjct: 276 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDE---RVIITGSSDSTVRVW 332

Query: 441 NVQKGKIIQRFNEHGTNGIFCIAWSHK--DSKRIATCSSDGFCIIRTIDGKVLHKYK--- 495
           +V  G+++     H      C A  H   ++  + TCS D    +  +        +   
Sbjct: 333 DVNTGEMLNTLIHH------CEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVL 386

Query: 496 --HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPL 553
             H AAV   D+       I +   D  ++V+   TS+ + ++  +GH   +  +++   
Sbjct: 387 VGHRAAVNVVDFDDK---YIVSASGDRTIKVWN--TSTCEFVRTLNGHKRGIACLQY--- 438

Query: 554 REGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVW 613
           R+ ++ SGS D T+R+WD    AC+ +L GH   VR + ++ +    ++SG++D  IKVW
Sbjct: 439 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNK---RIVSGAYDGKIKVW 495

Query: 614 D--------TREGT-CVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLW 656
           D           GT C+ T+ +H   V+ L       F + S S D T+ +W
Sbjct: 496 DLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFD---EFQIVSSSHDDTILIW 544



 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 47/155 (30%), Positives = 77/155 (49%), Gaps = 14/155 (9%)

Query: 507 QNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGT 566
           Q ++ +I TG  D+ VRV+ V T   + L     H   V H++++    G++ + S D +
Sbjct: 314 QYDERVIITGSSDSTVRVWDVNTG--EMLNTLIHHCEAVLHLRFN---NGMMVTCSKDRS 368

Query: 567 VRIWDYTQDACIN---ILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDT 623
           + +WD      I    +L GH A V  + ++ +    ++S S D TIKVW+T     V T
Sbjct: 369 IAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKY---IVSASGDRTIKVWNTSTCEFVRT 425

Query: 624 VYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 658
           +  H     G+ C   R   + S S D+T+RLW +
Sbjct: 426 LNGHKR---GIACLQYRDRLVVSGSSDNTIRLWDI 457



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 38/129 (29%), Positives = 63/129 (48%), Gaps = 16/129 (12%)

Query: 541 HTAKVFHVKWSPLREGILC---------SGSDDGTVRIWDYTQDACINILNGHTAPVRGL 591
           H+ +  H + S   +G+ C         SG  D T++IWD     C  IL GHT  V  L
Sbjct: 255 HSLQRIHCR-SETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCL 313

Query: 592 MWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDS 651
            ++  +   +I+GS D T++VWD   G  ++T+  H   V  L  +      M +CS+D 
Sbjct: 314 QYDERV---IITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGM---MVTCSKDR 367

Query: 652 TVRLWSLTA 660
           ++ +W + +
Sbjct: 368 SIAVWDMAS 376


>gi|16117783 beta-transducin repeat containing protein isoform 1
           [Homo sapiens]
          Length = 605

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 76/292 (26%), Positives = 131/292 (44%), Gaps = 39/292 (13%)

Query: 381 DPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIW 440
           D   + +   D TIK+WD NTL       G+ G +  L +       I  G+S +   +W
Sbjct: 312 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDE---RVIITGSSDSTVRVW 368

Query: 441 NVQKGKIIQRFNEHGTNGIFCIAWSHK--DSKRIATCSSDGFCIIRTIDGKVLHKYK--- 495
           +V  G+++     H      C A  H   ++  + TCS D    +  +        +   
Sbjct: 369 DVNTGEMLNTLIHH------CEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVL 422

Query: 496 --HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPL 553
             H AAV   D+       I +   D  ++V+   TS+ + ++  +GH   +  +++   
Sbjct: 423 VGHRAAVNVVDFDDK---YIVSASGDRTIKVWN--TSTCEFVRTLNGHKRGIACLQY--- 474

Query: 554 REGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVW 613
           R+ ++ SGS D T+R+WD    AC+ +L GH   VR + ++ +    ++SG++D  IKVW
Sbjct: 475 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNK---RIVSGAYDGKIKVW 531

Query: 614 D--------TREGT-CVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLW 656
           D           GT C+ T+ +H   V+ L       F + S S D T+ +W
Sbjct: 532 DLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFD---EFQIVSSSHDDTILIW 580



 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 47/155 (30%), Positives = 77/155 (49%), Gaps = 14/155 (9%)

Query: 507 QNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGT 566
           Q ++ +I TG  D+ VRV+ V T   + L     H   V H++++    G++ + S D +
Sbjct: 350 QYDERVIITGSSDSTVRVWDVNTG--EMLNTLIHHCEAVLHLRFN---NGMMVTCSKDRS 404

Query: 567 VRIWDYTQDACIN---ILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDT 623
           + +WD      I    +L GH A V  + ++ +    ++S S D TIKVW+T     V T
Sbjct: 405 IAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKY---IVSASGDRTIKVWNTSTCEFVRT 461

Query: 624 VYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 658
           +  H     G+ C   R   + S S D+T+RLW +
Sbjct: 462 LNGHKR---GIACLQYRDRLVVSGSSDNTIRLWDI 493



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 38/129 (29%), Positives = 63/129 (48%), Gaps = 16/129 (12%)

Query: 541 HTAKVFHVKWSPLREGILC---------SGSDDGTVRIWDYTQDACINILNGHTAPVRGL 591
           H+ +  H + S   +G+ C         SG  D T++IWD     C  IL GHT  V  L
Sbjct: 291 HSLQRIHCR-SETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCL 349

Query: 592 MWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDS 651
            ++  +   +I+GS D T++VWD   G  ++T+  H   V  L  +      M +CS+D 
Sbjct: 350 QYDERV---IITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGM---MVTCSKDR 403

Query: 652 TVRLWSLTA 660
           ++ +W + +
Sbjct: 404 SIAVWDMAS 412


>gi|48928050 F-box and WD repeat domain containing 11 isoform C
           [Homo sapiens]
          Length = 542

 Score = 87.8 bits (216), Expect = 6e-17
 Identities = 68/283 (24%), Positives = 126/283 (44%), Gaps = 41/283 (14%)

Query: 391 DGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQR 450
           D +IK+WD  +L  +    G+ G +  L +       I  G+S +   +W+V  G+++  
Sbjct: 259 DNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE---RVIVTGSSDSTVRVWDVNTGEVLNT 315

Query: 451 FNEHG--------TNGIFCIAWSHKDSKRIATCSSDGFCIIRTIDGKVLHKYKHPAAVFG 502
              H         +NG+       +        S+    + R + G       H AAV  
Sbjct: 316 LIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVG-------HRAAVNV 368

Query: 503 CDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGS 562
            D+       I +   D  ++V+  +TS+ + ++  +GH   +  +++   R+ ++ SGS
Sbjct: 369 VDFDDK---YIVSASGDRTIKVW--STSTCEFVRTLNGHKRGIACLQY---RDRLVVSGS 420

Query: 563 DDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREG---- 618
            D T+R+WD    AC+ +L GH   VR + ++ +    ++SG++D  IKVWD +      
Sbjct: 421 SDNTIRLWDIECGACLRVLEGHEELVRCIRFDNK---RIVSGAYDGKIKVWDLQAALDPR 477

Query: 619 -----TCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLW 656
                 C+ T+ +H   V+ L       F + S S D T+ +W
Sbjct: 478 APASTLCLRTLVEHSGRVFRLQFD---EFQIISSSHDDTILIW 517



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 48/155 (30%), Positives = 76/155 (49%), Gaps = 14/155 (9%)

Query: 507 QNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGT 566
           Q ++ +I TG  D+ VRV+ V T   + L     H   V H+++S    G++ + S D +
Sbjct: 287 QYDERVIVTGSSDSTVRVWDVNTG--EVLNTLIHHNEAVLHLRFS---NGLMVTCSKDRS 341

Query: 567 VRIWDYTQDACIN---ILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDT 623
           + +WD      I    +L GH A V  + ++ +    ++S S D TIKVW T     V T
Sbjct: 342 IAVWDMASATDITLRRVLVGHRAAVNVVDFDDKY---IVSASGDRTIKVWSTSTCEFVRT 398

Query: 624 VYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 658
           +  H     G+ C   R   + S S D+T+RLW +
Sbjct: 399 LNGHKR---GIACLQYRDRLVVSGSSDNTIRLWDI 430



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 31/103 (30%), Positives = 55/103 (53%), Gaps = 6/103 (5%)

Query: 558 LCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRE 617
           + SG  D +++IWD T   C+ +L GHT  V  L ++  +   +++GS D T++VWD   
Sbjct: 253 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERV---IVTGSSDSTVRVWDVNT 309

Query: 618 GTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTA 660
           G  ++T+  H   V  L         M +CS+D ++ +W + +
Sbjct: 310 GEVLNTLIHHNEAVLHLRFSNG---LMVTCSKDRSIAVWDMAS 349



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 57/236 (24%), Positives = 96/236 (40%), Gaps = 49/236 (20%)

Query: 339 GHAVCCFLDGGVGLYDMGAKKWDFLRDL--GHVETIFDCKFKPDDPNLLATASFDGTIKV 396
           G  V C  D  + ++DM +     LR +  GH   +    F   D   + +AS D TIKV
Sbjct: 331 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF---DDKYIVSASGDRTIKV 387

Query: 397 WDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGT 456
           W  +T   V T  G++  I  L +       +  G+S N   +W+++ G  ++    H  
Sbjct: 388 WSTSTCEFVRTLNGHKRGIACLQYRD---RLVVSGSSDNTIRLWDIECGACLRVLEGH-E 443

Query: 457 NGIFCIAWSHKDSKRIATCSSDGFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATG 516
             + CI +   D+KRI + + DG   I+  D +     + PA               +T 
Sbjct: 444 ELVRCIRF---DNKRIVSGAYDG--KIKVWDLQAALDPRAPA---------------STL 483

Query: 517 CEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDY 572
           C                 L+    H+ +VF +++   +   + S S D T+ IWD+
Sbjct: 484 C-----------------LRTLVEHSGRVFRLQFDEFQ---IISSSHDDTILIWDF 519


>gi|48928048 F-box and WD repeat domain containing 11 isoform A
           [Homo sapiens]
          Length = 508

 Score = 87.8 bits (216), Expect = 6e-17
 Identities = 68/283 (24%), Positives = 126/283 (44%), Gaps = 41/283 (14%)

Query: 391 DGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQR 450
           D +IK+WD  +L  +    G+ G +  L +       I  G+S +   +W+V  G+++  
Sbjct: 225 DNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE---RVIVTGSSDSTVRVWDVNTGEVLNT 281

Query: 451 FNEHG--------TNGIFCIAWSHKDSKRIATCSSDGFCIIRTIDGKVLHKYKHPAAVFG 502
              H         +NG+       +        S+    + R + G       H AAV  
Sbjct: 282 LIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVG-------HRAAVNV 334

Query: 503 CDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGS 562
            D+       I +   D  ++V+  +TS+ + ++  +GH   +  +++   R+ ++ SGS
Sbjct: 335 VDFDDK---YIVSASGDRTIKVW--STSTCEFVRTLNGHKRGIACLQY---RDRLVVSGS 386

Query: 563 DDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREG---- 618
            D T+R+WD    AC+ +L GH   VR + ++ +    ++SG++D  IKVWD +      
Sbjct: 387 SDNTIRLWDIECGACLRVLEGHEELVRCIRFDNK---RIVSGAYDGKIKVWDLQAALDPR 443

Query: 619 -----TCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLW 656
                 C+ T+ +H   V+ L       F + S S D T+ +W
Sbjct: 444 APASTLCLRTLVEHSGRVFRLQFD---EFQIISSSHDDTILIW 483



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 48/155 (30%), Positives = 76/155 (49%), Gaps = 14/155 (9%)

Query: 507 QNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGT 566
           Q ++ +I TG  D+ VRV+ V T   + L     H   V H+++S    G++ + S D +
Sbjct: 253 QYDERVIVTGSSDSTVRVWDVNTG--EVLNTLIHHNEAVLHLRFS---NGLMVTCSKDRS 307

Query: 567 VRIWDYTQDACIN---ILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDT 623
           + +WD      I    +L GH A V  + ++ +    ++S S D TIKVW T     V T
Sbjct: 308 IAVWDMASATDITLRRVLVGHRAAVNVVDFDDKY---IVSASGDRTIKVWSTSTCEFVRT 364

Query: 624 VYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 658
           +  H     G+ C   R   + S S D+T+RLW +
Sbjct: 365 LNGHKR---GIACLQYRDRLVVSGSSDNTIRLWDI 396



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 31/103 (30%), Positives = 55/103 (53%), Gaps = 6/103 (5%)

Query: 558 LCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRE 617
           + SG  D +++IWD T   C+ +L GHT  V  L ++  +   +++GS D T++VWD   
Sbjct: 219 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERV---IVTGSSDSTVRVWDVNT 275

Query: 618 GTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTA 660
           G  ++T+  H   V  L         M +CS+D ++ +W + +
Sbjct: 276 GEVLNTLIHHNEAVLHLRFSNG---LMVTCSKDRSIAVWDMAS 315



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 57/236 (24%), Positives = 96/236 (40%), Gaps = 49/236 (20%)

Query: 339 GHAVCCFLDGGVGLYDMGAKKWDFLRDL--GHVETIFDCKFKPDDPNLLATASFDGTIKV 396
           G  V C  D  + ++DM +     LR +  GH   +    F   D   + +AS D TIKV
Sbjct: 297 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF---DDKYIVSASGDRTIKV 353

Query: 397 WDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGT 456
           W  +T   V T  G++  I  L +       +  G+S N   +W+++ G  ++    H  
Sbjct: 354 WSTSTCEFVRTLNGHKRGIACLQYRD---RLVVSGSSDNTIRLWDIECGACLRVLEGH-E 409

Query: 457 NGIFCIAWSHKDSKRIATCSSDGFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATG 516
             + CI +   D+KRI + + DG   I+  D +     + PA               +T 
Sbjct: 410 ELVRCIRF---DNKRIVSGAYDG--KIKVWDLQAALDPRAPA---------------STL 449

Query: 517 CEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDY 572
           C                 L+    H+ +VF +++   +   + S S D T+ IWD+
Sbjct: 450 C-----------------LRTLVEHSGRVFRLQFDEFQ---IISSSHDDTILIWDF 485


>gi|48928046 F-box and WD repeat domain containing 11 isoform B
           [Homo sapiens]
          Length = 529

 Score = 87.8 bits (216), Expect = 6e-17
 Identities = 68/283 (24%), Positives = 126/283 (44%), Gaps = 41/283 (14%)

Query: 391 DGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQR 450
           D +IK+WD  +L  +    G+ G +  L +       I  G+S +   +W+V  G+++  
Sbjct: 246 DNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE---RVIVTGSSDSTVRVWDVNTGEVLNT 302

Query: 451 FNEHG--------TNGIFCIAWSHKDSKRIATCSSDGFCIIRTIDGKVLHKYKHPAAVFG 502
              H         +NG+       +        S+    + R + G       H AAV  
Sbjct: 303 LIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVG-------HRAAVNV 355

Query: 503 CDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGS 562
            D+       I +   D  ++V+  +TS+ + ++  +GH   +  +++   R+ ++ SGS
Sbjct: 356 VDFDDK---YIVSASGDRTIKVW--STSTCEFVRTLNGHKRGIACLQY---RDRLVVSGS 407

Query: 563 DDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREG---- 618
            D T+R+WD    AC+ +L GH   VR + ++ +    ++SG++D  IKVWD +      
Sbjct: 408 SDNTIRLWDIECGACLRVLEGHEELVRCIRFDNK---RIVSGAYDGKIKVWDLQAALDPR 464

Query: 619 -----TCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLW 656
                 C+ T+ +H   V+ L       F + S S D T+ +W
Sbjct: 465 APASTLCLRTLVEHSGRVFRLQFD---EFQIISSSHDDTILIW 504



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 48/155 (30%), Positives = 76/155 (49%), Gaps = 14/155 (9%)

Query: 507 QNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGT 566
           Q ++ +I TG  D+ VRV+ V T   + L     H   V H+++S    G++ + S D +
Sbjct: 274 QYDERVIVTGSSDSTVRVWDVNTG--EVLNTLIHHNEAVLHLRFS---NGLMVTCSKDRS 328

Query: 567 VRIWDYTQDACIN---ILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDT 623
           + +WD      I    +L GH A V  + ++ +    ++S S D TIKVW T     V T
Sbjct: 329 IAVWDMASATDITLRRVLVGHRAAVNVVDFDDKY---IVSASGDRTIKVWSTSTCEFVRT 385

Query: 624 VYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 658
           +  H     G+ C   R   + S S D+T+RLW +
Sbjct: 386 LNGHKR---GIACLQYRDRLVVSGSSDNTIRLWDI 417



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 31/103 (30%), Positives = 55/103 (53%), Gaps = 6/103 (5%)

Query: 558 LCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRE 617
           + SG  D +++IWD T   C+ +L GHT  V  L ++  +   +++GS D T++VWD   
Sbjct: 240 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERV---IVTGSSDSTVRVWDVNT 296

Query: 618 GTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTA 660
           G  ++T+  H   V  L         M +CS+D ++ +W + +
Sbjct: 297 GEVLNTLIHHNEAVLHLRFSNG---LMVTCSKDRSIAVWDMAS 336



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 57/236 (24%), Positives = 96/236 (40%), Gaps = 49/236 (20%)

Query: 339 GHAVCCFLDGGVGLYDMGAKKWDFLRDL--GHVETIFDCKFKPDDPNLLATASFDGTIKV 396
           G  V C  D  + ++DM +     LR +  GH   +    F   D   + +AS D TIKV
Sbjct: 318 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF---DDKYIVSASGDRTIKV 374

Query: 397 WDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGT 456
           W  +T   V T  G++  I  L +       +  G+S N   +W+++ G  ++    H  
Sbjct: 375 WSTSTCEFVRTLNGHKRGIACLQYRD---RLVVSGSSDNTIRLWDIECGACLRVLEGH-E 430

Query: 457 NGIFCIAWSHKDSKRIATCSSDGFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATG 516
             + CI +   D+KRI + + DG   I+  D +     + PA               +T 
Sbjct: 431 ELVRCIRF---DNKRIVSGAYDG--KIKVWDLQAALDPRAPA---------------STL 470

Query: 517 CEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDY 572
           C                 L+    H+ +VF +++   +   + S S D T+ IWD+
Sbjct: 471 C-----------------LRTLVEHSGRVFRLQFDEFQ---IISSSHDDTILIWDF 506


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score = 87.4 bits (215), Expect = 8e-17
 Identities = 77/278 (27%), Positives = 131/278 (47%), Gaps = 30/278 (10%)

Query: 361 DFLRDL-GHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLS 419
           DF R L GH +++ D  F      LLA+ S D TIK+WD      + T  G++  + S++
Sbjct: 141 DFERTLKGHTDSVQDISFDHSG-KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVA 199

Query: 420 WAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDG 479
             P G + ++    +    +W VQ G  ++ F  H       +   ++D   IA+CS+D 
Sbjct: 200 IMPNGDHIVSASRDKT-IKMWEVQTGYCVKTFTGH--REWVRMVRPNQDGTLIASCSNDQ 256

Query: 480 FC---IIRTIDGKV-LHKYKH--------PAAVF-------GCDWSQNNKD--MIATGCE 518
                ++ T + K  L +++H        P + +       G +  ++ K    + +G  
Sbjct: 257 TVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSR 316

Query: 519 DTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACI 578
           D  ++++ V+T     L    GH   V  V +    + IL S +DD T+R+WDY    C+
Sbjct: 317 DKTIKMWDVSTG--MCLMTLVGHDNWVRGVLFHSGGKFIL-SCADDKTLRVWDYKNKRCM 373

Query: 579 NILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTR 616
             LN H   V  L ++   PY +++GS D T+KVW+ R
Sbjct: 374 KTLNAHEHFVTSLDFHKTAPY-VVTGSVDQTVKVWECR 410



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 70/247 (28%), Positives = 108/247 (43%), Gaps = 44/247 (17%)

Query: 439 IWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSD---------GFCIIRTIDGK 489
           +W+ + G   +    H T+ +  I++ H   K +A+CS+D         GF  IRT+ G 
Sbjct: 134 VWDYETGDFERTLKGH-TDSVQDISFDHS-GKLLASCSADMTIKLWDFQGFECIRTMHG- 190

Query: 490 VLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVK 549
             H +   +          N D I +   D  ++++ V T     +K F+GH   V  V+
Sbjct: 191 --HDHNVSSVAI-----MPNGDHIVSASRDKTIKMWEVQTG--YCVKTFTGHREWVRMVR 241

Query: 550 WSPLREG-ILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPY--------- 599
             P ++G ++ S S+D TVR+W      C   L  H   V  + W  E  Y         
Sbjct: 242 --PNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGS 299

Query: 600 ----------LLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSR 649
                      L+SGS D TIK+WD   G C+ T+  H   V G+  H    F + SC+ 
Sbjct: 300 ETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFIL-SCAD 358

Query: 650 DSTVRLW 656
           D T+R+W
Sbjct: 359 DKTLRVW 365



 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 82/311 (26%), Positives = 136/311 (43%), Gaps = 61/311 (19%)

Query: 383 NLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGG---LNCIAGGTSRNGAFI 439
           +++ +AS D TIKVWD  T     T  G+   +  +S+   G    +C A  T +    +
Sbjct: 121 SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIK----L 176

Query: 440 WNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSD----------GFCIIRTIDGK 489
           W+ Q  + I+  + H  N        + D   I + S D          G+C ++T  G 
Sbjct: 177 WDFQGFECIRTMHGHDHNVSSVAIMPNGD--HIVSASRDKTIKMWEVQTGYC-VKTFTG- 232

Query: 490 VLHKYKHPAAVFGCDW---SQNNKD--MIATGCEDTNVRVYYVATSSDQPLKVFSGHTAK 544
             H+          +W    + N+D  +IA+   D  VRV+ VAT   +       H   
Sbjct: 233 --HR----------EWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECK--AELREHEHV 278

Query: 545 VFHVKWSP------LREG-------------ILCSGSDDGTVRIWDYTQDACINILNGHT 585
           V  + W+P      + E               L SGS D T+++WD +   C+  L GH 
Sbjct: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHD 338

Query: 586 APVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMA 645
             VRG+++++   ++L S + D T++VWD +   C+ T+  H   V  L  H + P+ + 
Sbjct: 339 NWVRGVLFHSGGKFIL-SCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVT 397

Query: 646 SCSRDSTVRLW 656
             S D TV++W
Sbjct: 398 G-SVDQTVKVW 407



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 39/120 (32%), Positives = 65/120 (54%), Gaps = 3/120 (2%)

Query: 539 SGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIP 598
           SGH + V  V + P+   ++ S S+D T+++WDY        L GHT  V+ + ++    
Sbjct: 105 SGHRSPVTRVIFHPVFS-VMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFD-HSG 162

Query: 599 YLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 658
            LL S S D TIK+WD +   C+ T++ H  +V  +   P+    + S SRD T+++W +
Sbjct: 163 KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDH-IVSASRDKTIKMWEV 221


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 77/309 (24%), Positives = 137/309 (44%), Gaps = 25/309 (8%)

Query: 361 DFLRDLGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPG---NEGVIY- 416
           +F   +G    I  C F P+   +LATA + G  K+W +     ++T  G   N G I  
Sbjct: 223 NFCSQIGDDRPISYCHFSPNS-KMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVF 281

Query: 417 ----SLSWAPGGLN---CIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDS 469
               ++S  P  +N   C A G+ +    +W++   + +     H T  +  + W H   
Sbjct: 282 HPKSTVSLDPKDVNLASCAADGSVK----LWSLDSDEPVADIEGH-TVRVARVMW-HPSG 335

Query: 470 KRIATCSSDGFCIIRTIDGK--VLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYV 527
           + + T   D    +  ++ +  +LH+  H   V+   + Q+   +  TG  D   RV+ +
Sbjct: 336 RFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGS-LAGTGGLDAFGRVWDL 394

Query: 528 ATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAP 587
            T   + +    GH  +++ + +SP    I  +GS D T ++WD  Q  C+  +  H   
Sbjct: 395 RTG--RCIMFLEGHLKEIYGINFSPNGYHI-ATGSGDNTCKVWDLRQRRCVYTIPAHQNL 451

Query: 588 VRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASC 647
           V G+ +       L++G++D T K+W     + + T+  H   V GL    S    +A+C
Sbjct: 452 VTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDI-SSDGQLIATC 510

Query: 648 SRDSTVRLW 656
           S D T +LW
Sbjct: 511 SYDRTFKLW 519



 Score = 38.9 bits (89), Expect = 0.032
 Identities = 18/66 (27%), Positives = 31/66 (46%), Gaps = 7/66 (10%)

Query: 600 LLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPS-------RPFTMASCSRDST 652
           +L +  W    K+W   +   + T+  H  +V  +  HP        +   +ASC+ D +
Sbjct: 245 MLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGS 304

Query: 653 VRLWSL 658
           V+LWSL
Sbjct: 305 VKLWSL 310


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 70/293 (23%), Positives = 123/293 (41%), Gaps = 50/293 (17%)

Query: 367 GHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLN 426
           GH   I D  +  D  NLL +AS D T+K+WD+++   + T  G+   ++  ++ P   N
Sbjct: 85  GHKLGISDVAWSSDS-NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS-N 142

Query: 427 CIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCIIRTI 486
            I  G+      IW+V+ GK ++    H ++ +  + ++ +D   I + S DG C I   
Sbjct: 143 LIVSGSFDESVRIWDVKTGKCLKTLPAH-SDPVSAVHFN-RDGSLIVSSSYDGLCRI--- 197

Query: 487 DGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVF 546
                             W   +   + T  +D N  V +V                   
Sbjct: 198 ------------------WDTASGQCLKTLIDDDNPPVSFV------------------- 220

Query: 547 HVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIP--YLLISG 604
             K+SP  + IL +  D+ T+++WDY++  C+    GH      +  N  +     ++SG
Sbjct: 221 --KFSPNGKYILAATLDN-TLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277

Query: 605 SWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP-FTMASCSRDSTVRLW 656
           S D  + +W+ +    V  +  H   V    CHP+      A+   D T++LW
Sbjct: 278 SEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 73/259 (28%), Positives = 126/259 (48%), Gaps = 15/259 (5%)

Query: 406 YTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWS 465
           +T  G+   + S+ ++P G   +A  ++     IW    GK  +  + H   GI  +AWS
Sbjct: 39  FTLAGHTKAVSSVKFSPNG-EWLASSSADKLIKIWGAYDGKFEKTISGHKL-GISDVAWS 96

Query: 466 HKDSKRIATCSSDGFCIIRTID-GKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVR 523
             DS  + + S D    I  +  GK L   K H   VF C+++  + ++I +G  D +VR
Sbjct: 97  -SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVR 154

Query: 524 VYYVATSSDQPLKVFSGHTAKVFHVKWSPLREG-ILCSGSDDGTVRIWDYTQDACIN-IL 581
           ++ V T   + LK    H+  V  V ++  R+G ++ S S DG  RIWD     C+  ++
Sbjct: 155 IWDVKTG--KCLKTLPAHSDPVSAVHFN--RDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210

Query: 582 NGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPS-- 639
           +    PV  + ++    Y+L + + D T+K+WD  +G C+ T   H  + Y +  + S  
Sbjct: 211 DDDNPPVSFVKFSPNGKYIL-AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269

Query: 640 RPFTMASCSRDSTVRLWSL 658
               + S S D+ V +W+L
Sbjct: 270 GGKWIVSGSEDNLVYIWNL 288



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 59/267 (22%), Positives = 106/267 (39%), Gaps = 22/267 (8%)

Query: 49  FKLHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASL 108
           + L   ++ H K ++++ + P N +  AS S D L+ IW   + K    +   K   + +
Sbjct: 35  YALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93

Query: 109 SWCWNAEDVVAFVSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFG 168
           +W  ++  +V+  S    L IW +S      +     HS     C F     Q   +V G
Sbjct: 94  AWSSDSNLLVS-ASDDKTLKIWDVS--SGKCLKTLKGHSNYVFCCNF---NPQSNLIVSG 147

Query: 169 HIDGSLSIFHPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLLVVNLHYG--IRL 226
             D S+ I+          L   S       DPV+A+ +   + D  L+V+  Y    R+
Sbjct: 148 SFDESVRIWDVKTGKCLKTLPAHS-------DPVSAVHF---NRDGSLIVSSSYDGLCRI 197

Query: 227 VDSESLSCITTFNLPSAAASVQCLAWVPSAPGMFITGDSQVGVLRIWNVSRTTPIDNLKL 286
            D+ S  C+ T  +      V  + + P+  G +I   +    L++W+ S+   +     
Sbjct: 198 WDTASGQCLKTL-IDDDNPPVSFVKFSPN--GKYILAATLDNTLKLWDYSKGKCLKTYTG 254

Query: 287 KKTGFHCLHVLNSPPRKKFSVQSPTKN 313
            K   +C+    S    K+ V     N
Sbjct: 255 HKNEKYCIFANFSVTGGKWIVSGSEDN 281



 Score = 34.3 bits (77), Expect = 0.80
 Identities = 16/43 (37%), Positives = 26/43 (60%), Gaps = 1/43 (2%)

Query: 77  SGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDVVA 119
           SGS DNLV IWN+  ++++ KL     +  S + C   E+++A
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA-CHPTENIIA 317


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 70/293 (23%), Positives = 123/293 (41%), Gaps = 50/293 (17%)

Query: 367 GHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLN 426
           GH   I D  +  D  NLL +AS D T+K+WD+++   + T  G+   ++  ++ P   N
Sbjct: 85  GHKLGISDVAWSSDS-NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS-N 142

Query: 427 CIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCIIRTI 486
            I  G+      IW+V+ GK ++    H ++ +  + ++ +D   I + S DG C I   
Sbjct: 143 LIVSGSFDESVRIWDVKTGKCLKTLPAH-SDPVSAVHFN-RDGSLIVSSSYDGLCRI--- 197

Query: 487 DGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVF 546
                             W   +   + T  +D N  V +V                   
Sbjct: 198 ------------------WDTASGQCLKTLIDDDNPPVSFV------------------- 220

Query: 547 HVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIP--YLLISG 604
             K+SP  + IL +  D+ T+++WDY++  C+    GH      +  N  +     ++SG
Sbjct: 221 --KFSPNGKYILAATLDN-TLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277

Query: 605 SWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP-FTMASCSRDSTVRLW 656
           S D  + +W+ +    V  +  H   V    CHP+      A+   D T++LW
Sbjct: 278 SEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 73/259 (28%), Positives = 126/259 (48%), Gaps = 15/259 (5%)

Query: 406 YTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWS 465
           +T  G+   + S+ ++P G   +A  ++     IW    GK  +  + H   GI  +AWS
Sbjct: 39  FTLAGHTKAVSSVKFSPNG-EWLASSSADKLIKIWGAYDGKFEKTISGHKL-GISDVAWS 96

Query: 466 HKDSKRIATCSSDGFCIIRTID-GKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVR 523
             DS  + + S D    I  +  GK L   K H   VF C+++  + ++I +G  D +VR
Sbjct: 97  -SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVR 154

Query: 524 VYYVATSSDQPLKVFSGHTAKVFHVKWSPLREG-ILCSGSDDGTVRIWDYTQDACIN-IL 581
           ++ V T   + LK    H+  V  V ++  R+G ++ S S DG  RIWD     C+  ++
Sbjct: 155 IWDVKTG--KCLKTLPAHSDPVSAVHFN--RDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210

Query: 582 NGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPS-- 639
           +    PV  + ++    Y+L + + D T+K+WD  +G C+ T   H  + Y +  + S  
Sbjct: 211 DDDNPPVSFVKFSPNGKYIL-AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269

Query: 640 RPFTMASCSRDSTVRLWSL 658
               + S S D+ V +W+L
Sbjct: 270 GGKWIVSGSEDNLVYIWNL 288



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 59/267 (22%), Positives = 106/267 (39%), Gaps = 22/267 (8%)

Query: 49  FKLHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASL 108
           + L   ++ H K ++++ + P N +  AS S D L+ IW   + K    +   K   + +
Sbjct: 35  YALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93

Query: 109 SWCWNAEDVVAFVSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFG 168
           +W  ++  +V+  S    L IW +S      +     HS     C F     Q   +V G
Sbjct: 94  AWSSDSNLLVS-ASDDKTLKIWDVS--SGKCLKTLKGHSNYVFCCNF---NPQSNLIVSG 147

Query: 169 HIDGSLSIFHPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLLVVNLHYG--IRL 226
             D S+ I+          L   S       DPV+A+ +   + D  L+V+  Y    R+
Sbjct: 148 SFDESVRIWDVKTGKCLKTLPAHS-------DPVSAVHF---NRDGSLIVSSSYDGLCRI 197

Query: 227 VDSESLSCITTFNLPSAAASVQCLAWVPSAPGMFITGDSQVGVLRIWNVSRTTPIDNLKL 286
            D+ S  C+ T  +      V  + + P+  G +I   +    L++W+ S+   +     
Sbjct: 198 WDTASGQCLKTL-IDDDNPPVSFVKFSPN--GKYILAATLDNTLKLWDYSKGKCLKTYTG 254

Query: 287 KKTGFHCLHVLNSPPRKKFSVQSPTKN 313
            K   +C+    S    K+ V     N
Sbjct: 255 HKNEKYCIFANFSVTGGKWIVSGSEDN 281



 Score = 34.3 bits (77), Expect = 0.80
 Identities = 16/43 (37%), Positives = 26/43 (60%), Gaps = 1/43 (2%)

Query: 77  SGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDVVA 119
           SGS DNLV IWN+  ++++ KL     +  S + C   E+++A
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA-CHPTENIIA 317


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 84.0 bits (206), Expect = 9e-16
 Identities = 75/300 (25%), Positives = 127/300 (42%), Gaps = 20/300 (6%)

Query: 366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGL 425
           +GH E +   KF P+    LA++S D  I +W         T  G+   I  ++W+    
Sbjct: 38  VGHTEAVSSVKFSPNG-EWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96

Query: 426 NCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCIIRT 485
             ++    +    +W+V+ GK ++    H +N +FC  ++   +  I+    +   I   
Sbjct: 97  RLVSASDDKT-LKLWDVRSGKCLKTLKGH-SNYVFCCNFNPPSNLIISGSFDETVKIWEV 154

Query: 486 IDGKVL-----HKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVF-S 539
             GK L     H     A  F C  S     +I +G  D   R++  A  S Q LK    
Sbjct: 155 KTGKCLKTLSAHSDPVSAVHFNCSGS-----LIVSGSYDGLCRIWDAA--SGQCLKTLVD 207

Query: 540 GHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIP- 598
                V  VK+SP  + IL + + D T+++WDY++  C+    GH      +  N  +  
Sbjct: 208 DDNPPVSFVKFSPNGKYIL-TATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTG 266

Query: 599 -YLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP-FTMASCSRDSTVRLW 656
              ++SGS D  + +W+ +    V  +  H   V    CHP+      A+   D T++LW
Sbjct: 267 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 72/257 (28%), Positives = 120/257 (46%), Gaps = 13/257 (5%)

Query: 407 TSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSH 466
           T  G+   + S+ ++P G   +A  ++     IW    GK  +    H    I  +AWS 
Sbjct: 36  TLVGHTEAVSSVKFSPNG-EWLASSSADRLIIIWGAYDGKYEKTLYGHNLE-ISDVAWS- 92

Query: 467 KDSKRIATCSSDGFCIIRTI-DGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRV 524
            DS R+ + S D    +  +  GK L   K H   VF C+++  + ++I +G  D  V++
Sbjct: 93  SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPS-NLIISGSFDETVKI 151

Query: 525 YYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINIL-NG 583
           + V T   + LK  S H+  V  V ++     ++ SGS DG  RIWD     C+  L + 
Sbjct: 152 WEVKTG--KCLKTLSAHSDPVSAVHFN-CSGSLIVSGSYDGLCRIWDAASGQCLKTLVDD 208

Query: 584 HTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPS--RP 641
              PV  + ++    Y+L + + D T+K+WD   G C+ T   H  + Y +  + S    
Sbjct: 209 DNPPVSFVKFSPNGKYIL-TATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGG 267

Query: 642 FTMASCSRDSTVRLWSL 658
             + S S D+ V +W+L
Sbjct: 268 KWIVSGSEDNLVYIWNL 284



 Score = 37.0 bits (84), Expect = 0.12
 Identities = 73/356 (20%), Positives = 138/356 (38%), Gaps = 61/356 (17%)

Query: 49  FKLHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASL 108
           + L   +  H + ++++ + P N +  AS S D L+IIW   + K    L       + +
Sbjct: 31  YALKCTLVGHTEAVSSVKFSP-NGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDV 89

Query: 109 SWCWNAEDVVAFVSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFG 168
           +W  ++  +V+  S    L +W +       +     HS     C F         ++ G
Sbjct: 90  AWSSDSSRLVS-ASDDKTLKLWDVR--SGKCLKTLKGHSNYVFCCNF---NPPSNLIISG 143

Query: 169 HIDGSLSIFHPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLLVVNLHYGI-RLV 227
             D ++ I+          L   S       DPV+A+ ++   +  L+V   + G+ R+ 
Sbjct: 144 SFDETVKIWEVKTGKCLKTLSAHS-------DPVSAVHFN--CSGSLIVSGSYDGLCRIW 194

Query: 228 DSESLSCITTFNLPSAAASVQCLAWVPSAPGMFITGDSQVGVLRIWNVSRTTPIDNLKLK 287
           D+ S  C+ T  +      V  + + P+  G +I   +    L++W+ SR   +      
Sbjct: 195 DAASGQCLKTL-VDDDNPPVSFVKFSPN--GKYILTATLDNTLKLWDYSRGRCLKTYTGH 251

Query: 288 KTGFHCLHVLNSPPRKKFSVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLD 347
           K   +C+          F+  S T   +  S SE                         D
Sbjct: 252 KNEKYCI----------FANFSVTGGKWIVSGSE-------------------------D 276

Query: 348 GGVGLYDMGAKKWDFLRDL-GHVETIFDCKFKPDDPNLLATASF--DGTIKVWDIN 400
             V ++++  K  + ++ L GH + +      P + NL+A+A+   D TIK+W  N
Sbjct: 277 NLVYIWNLQTK--EIVQKLQGHTDVVISAACHPTE-NLIASAALENDKTIKLWMSN 329


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 63/216 (29%), Positives = 101/216 (46%), Gaps = 14/216 (6%)

Query: 468 DSKRIATCSSD---GFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRV 524
           DS  + +CS D    +  + +    VL++  H   V+  D S  +    A+G  D   R+
Sbjct: 353 DSSGLLSCSEDMSIRYWDLGSFTNTVLYQ-GHAYPVWDLDISPYSL-YFASGSHDRTARL 410

Query: 525 YYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGH 584
           +  +     PL++++GH A V  VK+ P     L +GS D TVR+W   Q   + +  GH
Sbjct: 411 W--SFDRTYPLRIYAGHLADVDCVKFHP-NSNYLATGSTDKTVRLWSAQQGNSVRLFTGH 467

Query: 585 TAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTM 644
             PV  L ++    YL  +G  D  +K+WD   GT    +  H  ++  LT  P     +
Sbjct: 468 RGPVLSLAFSPNGKYLASAGE-DQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGL-I 525

Query: 645 ASCSRDSTVRLWSLTALVTPVQINILADRSWEEIIG 680
           AS S D++VR+W     +     +  AD S  E++G
Sbjct: 526 ASASMDNSVRVWD----IRNTYCSAPADGSSSELVG 557



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 61/254 (24%), Positives = 115/254 (45%), Gaps = 12/254 (4%)

Query: 340 HAVCCFLDGGVGLYDMGAKKWDFLRDLGHVETIFDCKFKPDDPNLLATASFDGTIKVWDI 399
           H  C  L+      D    +   LR  GH   ++  +F  D   LL+  S D +I+ WD+
Sbjct: 315 HLACDILEEEDDEDDNAGTEMKILR--GHCGPVYSTRFLADSSGLLS-CSEDMSIRYWDL 371

Query: 400 NTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGI 459
            + T      G+   ++ L  +P  L   +G   R  A +W+  +   ++ +  H  + +
Sbjct: 372 GSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRT-ARLWSFDRTYPLRIYAGHLAD-V 429

Query: 460 FCIAWSHKDSKRIATCSSDGFCIIRTID-GKVLHKYK-HPAAVFGCDWSQNNKDMIATGC 517
            C+ + H +S  +AT S+D    + +   G  +  +  H   V    +S N K + + G 
Sbjct: 430 DCVKF-HPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAG- 487

Query: 518 EDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDAC 577
           ED  ++++ +A+ +    K   GHT  +  + +SP   G++ S S D +VR+WD     C
Sbjct: 488 EDQRLKLWDLASGT--LYKELRGHTDNITSLTFSP-DSGLIASASMDNSVRVWDIRNTYC 544

Query: 578 INILNGHTAPVRGL 591
               +G ++ + G+
Sbjct: 545 SAPADGSSSELVGV 558


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 81.3 bits (199), Expect = 6e-15
 Identities = 80/340 (23%), Positives = 145/340 (42%), Gaps = 52/340 (15%)

Query: 367 GHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLN 426
           GH E +    F P     LA+ S D T++ WD++T T  +T  G+   + S+SW+P G  
Sbjct: 112 GHSEAVISVAFSPTG-KYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRK 170

Query: 427 CIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAW----SHKDSKRIATCSSDGFC- 481
            +A G       +W+   GK + R     +  I  ++W    ++ + + +A+ S DG   
Sbjct: 171 -LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 229

Query: 482 IIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVY--------------- 525
           I  T  G+       H  +V    W  +   ++ +  +D  ++V+               
Sbjct: 230 IWDTTAGRCERILTGHTQSVTCLRWGGDG--LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287

Query: 526 ----YVATSSDQPLKVFSGHTAKV------FHVKWSPLREGI--------------LCSG 561
                +A S+D  L+  +   A+              L+E                L SG
Sbjct: 288 HWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSG 347

Query: 562 SDDGTVRIWDYTQD-ACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTC 620
           SDD T+ +W   +D   +  + GH A +  ++++ +   ++ S S+D +IK+WD R G  
Sbjct: 348 SDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPD-SRIVASASFDKSIKLWDGRTGKY 406

Query: 621 VDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTA 660
           + ++  H A VY +         + S S DST+++W + A
Sbjct: 407 LASLRGHVAAVYQIAWSADSRL-LVSGSSDSTLKVWDVKA 445



 Score = 78.2 bits (191), Expect = 5e-14
 Identities = 87/367 (23%), Positives = 141/367 (38%), Gaps = 66/367 (17%)

Query: 345 FLDGGVGLYDMGAKKWDFLRDL------GHVETIFDCKFKPDDPNLLATASFDGTIKVWD 398
           +L  G G  D   + WD   +       GH   +    + PD   L A+   +G I +WD
Sbjct: 128 YLASGSG--DTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKL-ASGCKNGQILLWD 184

Query: 399 INTLTAV-YTSPGNEGVIYSLSWAPGGLN----CIAGGTSRNGAFIWNVQKGKIIQRFNE 453
            +T   V  T  G+   I  LSW P   N     +A  +      IW+   G+  +    
Sbjct: 185 PSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTG 244

Query: 454 HGTNGIFCIAW-------SHKDSKRIATCSSDGFCIIRTIDGKVLHKYKHPAAVFGCDW- 505
           H T  + C+ W       S    + I    +    + RT+ G   H +         D+ 
Sbjct: 245 H-TQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQG---HGHWVNTMALSTDYA 300

Query: 506 -----------SQNNKDM-------------------------IATGCEDTNVRVYYVAT 529
                      S N +D+                         + +G +D  + ++  A 
Sbjct: 301 LRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAE 360

Query: 530 SSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVR 589
              +PL   +GH A +  V +SP    I+ S S D ++++WD      +  L GH A V 
Sbjct: 361 DK-KPLTRMTGHQALINQVLFSP-DSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVY 418

Query: 590 GLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSR 649
            + W+ +   LL+SGS D T+KVWD +       +  H  +VY +   P     +AS  +
Sbjct: 419 QIAWSAD-SRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ-RVASGGK 476

Query: 650 DSTVRLW 656
           D  +R+W
Sbjct: 477 DKCLRIW 483


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 61/248 (24%), Positives = 106/248 (42%), Gaps = 49/248 (19%)

Query: 367 GHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLN 426
           GH   ++   F PD  N L ++S DGT+++W + T T +    G+   ++   ++P G  
Sbjct: 541 GHSGPVYGASFSPDR-NYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYY 599

Query: 427 CIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCIIRTI 486
            ++GG  R  A +W                                   ++D +  +R  
Sbjct: 600 FVSGGHDRV-ARLW-----------------------------------ATDHYQPLRIF 623

Query: 487 DGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVF 546
            G +        A   C     N + +ATG  D  VR++ V   +   +++F+GH   + 
Sbjct: 624 AGHL--------ADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNC--VRIFTGHKGPIH 673

Query: 547 HVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSW 606
            + +SP     L +G+ DG V +WD      +  L GHT  V  L ++ +   +L SGS 
Sbjct: 674 SLTFSP-NGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRD-GEILASGSM 731

Query: 607 DYTIKVWD 614
           D T+++WD
Sbjct: 732 DNTVRLWD 739



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 73/289 (25%), Positives = 119/289 (41%), Gaps = 42/289 (14%)

Query: 380 DDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFI 439
           DD +L+A    D T++VW +                      P  L  +   +  +   +
Sbjct: 480 DDSSLIAGGFADSTVRVWSVT---------------------PKKLRSVKQASDLS---L 515

Query: 440 WNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSD-GFCIIRTIDGKV-------- 490
            + +   +++R  +  T     I + H      A+ S D  + +  + DG V        
Sbjct: 516 IDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTF 575

Query: 491 --LHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFH 547
             L  YK H   V+   +S      ++ G  D   R++  AT   QPL++F+GH A V  
Sbjct: 576 TCLVGYKGHNYPVWDTQFSPYGYYFVSGG-HDRVARLW--ATDHYQPLRIFAGHLADVNC 632

Query: 548 VKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWD 607
            ++ P     + +GS D TVR+WD     C+ I  GH  P+  L ++    + L +G+ D
Sbjct: 633 TRFHP-NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRF-LATGATD 690

Query: 608 YTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLW 656
             + +WD   G  V  +  H   V  L         +AS S D+TVRLW
Sbjct: 691 GRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEI-LASGSMDNTVRLW 738



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 48/144 (33%), Positives = 71/144 (49%), Gaps = 11/144 (7%)

Query: 518 EDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDAC 577
           +D   R+    T+S+  LK+  GH+  V+   +SP R  +L S S+DGTVR+W      C
Sbjct: 521 DDVLERIMDEKTASE--LKILYGHSGPVYGASFSPDRNYLL-SSSEDGTVRLWSLQTFTC 577

Query: 578 INILNGHTAPVRGLMWNTEIP---YLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGL 634
           +    GH  PV    W+T+     Y  +SG  D   ++W T     +     H ADV   
Sbjct: 578 LVGYKGHNYPV----WDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCT 633

Query: 635 TCHPSRPFTMASCSRDSTVRLWSL 658
             HP+  + +A+ S D TVRLW +
Sbjct: 634 RFHPNSNY-VATGSADRTVRLWDV 656



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 39/140 (27%), Positives = 73/140 (52%), Gaps = 13/140 (9%)

Query: 345 FLDGGVGLYDMGAKKW--DFLRDL----GHVETIFDCKFKPDDPNLLATASFDGTIKVWD 398
           F+ GG   +D  A+ W  D  + L    GH+  +   +F P+  N +AT S D T+++WD
Sbjct: 600 FVSGG---HDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNS-NYVATGSADRTVRLWD 655

Query: 399 INTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNG 458
           +     V    G++G I+SL+++P G   +A G +     +W++  G ++     H T+ 
Sbjct: 656 VLNGNCVRIFTGHKGPIHSLTFSPNG-RFLATGATDGRVLLWDIGHGLMVGELKGH-TDT 713

Query: 459 IFCIAWSHKDSKRIATCSSD 478
           +  + +S +D + +A+ S D
Sbjct: 714 VCSLRFS-RDGEILASGSMD 732



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 49/179 (27%), Positives = 78/179 (43%), Gaps = 19/179 (10%)

Query: 508 NNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTV 567
           ++  +IA G  D+ VRV+ V     + +K  S  +              ++   SDD   
Sbjct: 480 DDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLS--------------LIDKESDDVLE 525

Query: 568 RIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDH 627
           RI D    + + IL GH+ PV G  ++ +  YLL S S D T+++W  +  TC+     H
Sbjct: 526 RIMDEKTASELKILYGHSGPVYGASFSPDRNYLL-SSSEDGTVRLWSLQTFTCLVGYKGH 584

Query: 628 GADVYGLTCHPSRPFTMASCSRDSTVRLWSLTALVTPVQI--NILADRSWEEIIGNTDY 684
              V+     P   +   S   D   RLW+ T    P++I    LAD +      N++Y
Sbjct: 585 NYPVWDTQFSP-YGYYFVSGGHDRVARLWA-TDHYQPLRIFAGHLADVNCTRFHPNSNY 641



 Score = 30.8 bits (68), Expect = 8.8
 Identities = 19/77 (24%), Positives = 39/77 (50%), Gaps = 2/77 (2%)

Query: 54  IMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWN 113
           I + HK  I ++++ P N    A+G+TD  V++W++    ++ +L        SL +  +
Sbjct: 664 IFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRD 722

Query: 114 AEDVVAFVSHRGPLFIW 130
            E ++A  S    + +W
Sbjct: 723 GE-ILASGSMDNTVRLW 738


>gi|118402582 cell division cycle 20 [Homo sapiens]
          Length = 499

 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 77/287 (26%), Positives = 129/287 (44%), Gaps = 25/287 (8%)

Query: 383 NLLATASFDGTIKVW-----DINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGA 437
           N+LA A  D ++ +W     DI  L  +   PG    I S++W   G N +A GTS    
Sbjct: 196 NVLAVA-LDNSVYLWSASSGDILQLLQM-EQPGE--YISSVAWIKEG-NYLAVGTSSAEV 250

Query: 438 FIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCI---IRTIDGKVLHKY 494
            +W+VQ+ K ++    H    +  ++W+   S  +++ S  G      +R  +  V    
Sbjct: 251 QLWDVQQQKRLRNMTSHSAR-VGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATLS 306

Query: 495 KHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQ--PLKVFSGHTAKVFHVKWSP 552
            H   V G  W+ + + + A+G  D  V V+  A       PL+ F+ H   V  V W P
Sbjct: 307 GHSQEVCGLRWAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 365

Query: 553 LREGILCSG--SDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLIS-GSWDYT 609
            +  +L +G  + D  +RIW+    AC++ ++ H + V  ++W+     L+   G     
Sbjct: 366 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQ 424

Query: 610 IKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLW 656
           + +W       V  +  H + V  LT  P    T+AS + D T+RLW
Sbjct: 425 LVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLW 470



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 44/155 (28%), Positives = 69/155 (44%), Gaps = 11/155 (7%)

Query: 504 DWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREG-ILCSGS 562
           DWS  N  ++A   +++   VY  + SS   L++        +    + ++EG  L  G+
Sbjct: 191 DWSSGN--VLAVALDNS---VYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGT 245

Query: 563 DDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGT-CV 621
               V++WD  Q   +  +  H+A V  L WN+   Y+L SGS    I   D R     V
Sbjct: 246 SSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS---YILSSGSRSGHIHHHDVRVAEHHV 302

Query: 622 DTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLW 656
            T+  H  +V GL   P     +AS   D+ V +W
Sbjct: 303 ATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW 336



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 44/164 (26%), Positives = 69/164 (42%), Gaps = 24/164 (14%)

Query: 13  GCQPWNKDVCAASGDRFAYCATLAIYIYQLDHRYNEFKLHAIMSEHKKTITAISWCPHNP 72
           G   WN  + + SG R  +       I+  D R  E  + A +S H + +  + W P   
Sbjct: 272 GSLSWNSYILS-SGSRSGH-------IHHHDVRVAEHHV-ATLSGHSQEVCGLRWAPDGR 322

Query: 73  DLFASGSTDNLVIIWNVAEQK----VIAKLDSTKGIPASLSWCWNAEDVVAF---VSHRG 125
            L ASG  DNLV +W  A  +     +      +G   +++WC    +V+A     S R 
Sbjct: 323 HL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDR- 380

Query: 126 PLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGH 169
            + IW +       +   DAH   S +C   W  H K +++ GH
Sbjct: 381 HIRIWNVC--SGACLSAVDAH---SQVCSILWSPHYK-ELISGH 418


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.431 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,634,848
Number of Sequences: 37866
Number of extensions: 2492141
Number of successful extensions: 8817
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 176
Number of HSP's successfully gapped in prelim test: 153
Number of HSP's that attempted gapping in prelim test: 5442
Number of HSP's gapped (non-prelim): 1941
length of query: 1298
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1184
effective length of database: 13,930,794
effective search space: 16494060096
effective search space used: 16494060096
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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