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Search of human proteins with 55741571
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55741571 leucine rich repeat and fibronectin type III domain
containing 2 [Homo sapiens]
(789 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55741571 leucine rich repeat and fibronectin type III domain ... 1581 0.0
gi|31542244 leucine rich repeat and fibronectin type III domain ... 699 0.0
gi|149773484 leucine rich repeat and fibronectin type III domain... 639 0.0
gi|27363458 leucine rich repeat and fibronectin type III domain ... 626 e-179
gi|13375646 leucine rich repeat and fibronectin type III domain ... 607 e-173
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 152 9e-37
gi|51317373 netrin-G1 ligand [Homo sapiens] 142 1e-33
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 140 5e-33
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 139 1e-32
gi|109150416 peroxidasin [Homo sapiens] 127 4e-29
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 127 5e-29
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 125 2e-28
gi|126517478 peroxidasin homolog-like [Homo sapiens] 124 3e-28
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 110 5e-24
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 108 3e-23
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 108 3e-23
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 108 3e-23
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 104 3e-22
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 104 3e-22
gi|188528675 slit homolog 1 [Homo sapiens] 102 2e-21
gi|4759146 slit homolog 2 [Homo sapiens] 101 2e-21
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 100 9e-21
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 100 9e-21
gi|193083136 leucine-rich repeat, immunoglobulin-like and transm... 99 1e-20
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 96 1e-19
gi|225579152 insulin-like growth factor binding protein, acid la... 94 4e-19
gi|4826772 insulin-like growth factor binding protein, acid labi... 94 4e-19
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 94 6e-19
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 94 6e-19
gi|11321571 slit homolog 3 [Homo sapiens] 92 1e-18
>gi|55741571 leucine rich repeat and fibronectin type III domain
containing 2 [Homo sapiens]
Length = 789
Score = 1581 bits (4094), Expect = 0.0
Identities = 789/789 (100%), Positives = 789/789 (100%)
Query: 1 METLLGGLLAFGMAFAVVDACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLG 60
METLLGGLLAFGMAFAVVDACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLG
Sbjct: 1 METLLGGLLAFGMAFAVVDACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLG 60
Query: 61 GNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTL 120
GNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTL
Sbjct: 61 GNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTL 120
Query: 121 RGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSL 180
RGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSL
Sbjct: 121 RGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSL 180
Query: 181 DHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFG 240
DHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFG
Sbjct: 181 DHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFG 240
Query: 241 GNPLHCNCELLWLRRLERDDDLETCGSPGGLKGRYFWHVREEEFVCEPPLITQHTHKLLV 300
GNPLHCNCELLWLRRLERDDDLETCGSPGGLKGRYFWHVREEEFVCEPPLITQHTHKLLV
Sbjct: 241 GNPLHCNCELLWLRRLERDDDLETCGSPGGLKGRYFWHVREEEFVCEPPLITQHTHKLLV 300
Query: 301 LEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGTLDIFITTSQDSGAFTCI 360
LEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGTLDIFITTSQDSGAFTCI
Sbjct: 301 LEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGTLDIFITTSQDSGAFTCI 360
Query: 361 AANAAGEATAMVEVSIVQLPHLSNSTSRTAPPKSRLSDITGSSKTSRGGGGSGGGEPPKS 420
AANAAGEATAMVEVSIVQLPHLSNSTSRTAPPKSRLSDITGSSKTSRGGGGSGGGEPPKS
Sbjct: 361 AANAAGEATAMVEVSIVQLPHLSNSTSRTAPPKSRLSDITGSSKTSRGGGGSGGGEPPKS 420
Query: 421 PPERAVLVSEVTTTSALVKWSVSKSAPRVKMYQLQYNCSDDEVLIYRMIPASNKAFVVNN 480
PPERAVLVSEVTTTSALVKWSVSKSAPRVKMYQLQYNCSDDEVLIYRMIPASNKAFVVNN
Sbjct: 421 PPERAVLVSEVTTTSALVKWSVSKSAPRVKMYQLQYNCSDDEVLIYRMIPASNKAFVVNN 480
Query: 481 LVSGTGYDLCVLAMWDDTATTLTATNIVGCAQFFTKADYPQCQSMHSQILGGTMILVIGG 540
LVSGTGYDLCVLAMWDDTATTLTATNIVGCAQFFTKADYPQCQSMHSQILGGTMILVIGG
Sbjct: 481 LVSGTGYDLCVLAMWDDTATTLTATNIVGCAQFFTKADYPQCQSMHSQILGGTMILVIGG 540
Query: 541 IIVATLLVFIVILMVRYKVCNHEAPSKMAAAVSNVYSQTNGAQPPPPSSAPAGAPPQGPP 600
IIVATLLVFIVILMVRYKVCNHEAPSKMAAAVSNVYSQTNGAQPPPPSSAPAGAPPQGPP
Sbjct: 541 IIVATLLVFIVILMVRYKVCNHEAPSKMAAAVSNVYSQTNGAQPPPPSSAPAGAPPQGPP 600
Query: 601 KVVVRNELLDFTASLARASDSSSSSSLGSGEAAGLGRAPWRIPPSAPRPKPSLDRLMGAF 660
KVVVRNELLDFTASLARASDSSSSSSLGSGEAAGLGRAPWRIPPSAPRPKPSLDRLMGAF
Sbjct: 601 KVVVRNELLDFTASLARASDSSSSSSLGSGEAAGLGRAPWRIPPSAPRPKPSLDRLMGAF 660
Query: 661 ASLDLKSQRKEELLDSRTPAGRGAGTSARGHHSDREPLLGPPAARARSLLPLPLEGKAKR 720
ASLDLKSQRKEELLDSRTPAGRGAGTSARGHHSDREPLLGPPAARARSLLPLPLEGKAKR
Sbjct: 661 ASLDLKSQRKEELLDSRTPAGRGAGTSARGHHSDREPLLGPPAARARSLLPLPLEGKAKR 720
Query: 721 SHSFDMGDFAAAAAGGVVPGGYSPPRKVSNIWTKRSLSVNGMLLPFEESDLVGARGTFGS 780
SHSFDMGDFAAAAAGGVVPGGYSPPRKVSNIWTKRSLSVNGMLLPFEESDLVGARGTFGS
Sbjct: 721 SHSFDMGDFAAAAAGGVVPGGYSPPRKVSNIWTKRSLSVNGMLLPFEESDLVGARGTFGS 780
Query: 781 SEWVMESTV 789
SEWVMESTV
Sbjct: 781 SEWVMESTV 789
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 699 bits (1803), Expect = 0.0
Identities = 344/583 (59%), Positives = 441/583 (75%), Gaps = 6/583 (1%)
Query: 1 METLLGGLLAFGMAFAVVDACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLG 60
ME +L L G+A CPK CVCQ LS +L TLC KGLLFVPP+IDRRTVELRL
Sbjct: 1 MEKILFYLFLIGIAVKA-QICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLA 59
Query: 61 GNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTL 120
NF+ +I R+DFANMT LVDLTLSRNTIS I P +F DL +LR+LHL+SNRL + D
Sbjct: 60 DNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMF 119
Query: 121 RGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSL 180
GL NL HLI+NNNQL I+ AF+D + LE+LDLSYNNL +PWD+V +MV+LH LSL
Sbjct: 120 SGLSNLHHLILNNNQLTLISSTAFDD-VFALEELDLSYNNLETIPWDAVEKMVSLHTLSL 178
Query: 181 DHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFG 240
DHN++D+I +GTF+ L K+ RLD+TSN+LQKLPPDP+F R+Q A + + SFG
Sbjct: 179 DHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFG 238
Query: 241 GNPLHCNCELLWLRRLERDDDLETCGSPGGLKGRYFWHVREEEFVCEPPLITQHTHKLLV 300
GNPLHCNCELLWLRRL R+DDLETC SP L GRYFW + EEEF+CEPPLIT+HTH++ V
Sbjct: 239 GNPLHCNCELLWLRRLSREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRV 298
Query: 301 LEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGTLDIFITTSQDSGAFTCI 360
LEGQ ATL+CKA GDP P IHW++P+ +L+ N++R+ VYDNGTLDI ITT +D+GAFTCI
Sbjct: 299 LEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCI 358
Query: 361 AANAAGEATAMVEVSIVQLPHLSNSTSRTAPPKSRLSDITGSSKTSRGGGGSGGGEPPKS 420
A+N AGEAT +V++ I++LPHL NST+ P SDI+ S+K+ S G
Sbjct: 359 ASNPAGEATQIVDLHIIKLPHLLNSTNHIHEPDPGSSDISTSTKSGSNTSSSNG---DTK 415
Query: 421 PPERAVLVSEVTTTSALVKWSVSKSAPRVKMYQLQYNCSDDEVLIYRMIPASNKAFVVNN 480
+ ++V+E T+++AL+K++ ++ P ++M+Q+QYN + D+ L+YRMIP ++K F+VNN
Sbjct: 416 LSQDKIVVAEATSSTALLKFNFQRNIPGIRMFQIQYNGTYDDTLVYRMIPPTSKTFLVNN 475
Query: 481 LVSGTGYDLCVLAMWDDTATTLTATNIVGCAQFFTKADYPQCQSMHSQILGGTMILVIGG 540
L +GT YDLCVLA++DD T+LTAT +VGC QF T+ DY +C M SQ LGGTMI++IGG
Sbjct: 476 LAAGTMYDLCVLAIYDDGITSLTATRVVGCIQFTTEQDYVRCHFMQSQFLGGTMIIIIGG 535
Query: 541 IIVATLLVFIVILMVRYKVCNHEAPSKMAAAVSNVYSQTNGAQ 583
IIVA++LVFI+ILM+RYKVCN+ K+ VSNVYSQTNGAQ
Sbjct: 536 IIVASVLVFIIILMIRYKVCNNNGQHKV-TKVSNVYSQTNGAQ 577
>gi|149773484 leucine rich repeat and fibronectin type III domain
containing 1 [Homo sapiens]
Length = 771
Score = 639 bits (1647), Expect = 0.0
Identities = 370/787 (47%), Positives = 482/787 (61%), Gaps = 67/787 (8%)
Query: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVD 80
CP C+CQN++ +L LC GLLFVPP IDRR VELRL NFI + R+DFANMT LV
Sbjct: 34 CPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRRDFANMTSLVH 93
Query: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140
LTLSRNTI + +F DL +LR+LHLDSNRL + D LRGL NL+HLI+ NNQ+ +
Sbjct: 94 LTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRRVE 153
Query: 141 DEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLA 200
AF+ FL T+EDLDLSYNNL LPW++V +MVNL+ L+LDHNL+DHIAEGTF L KL
Sbjct: 154 SAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLV 213
Query: 201 RLDLTSNRLQKLPPDPIFARSQASALTATPFAP-PLSFSFGGNPLHCNCELLWLRRLERD 259
RLD+TSNRL KLPPD +F RSQ + P P PL+ SFGGNPLHCNCELLWLRRL R+
Sbjct: 214 RLDMTSNRLHKLPPDGLFLRSQGTG----PKPPTPLTVSFGGNPLHCNCELLWLRRLTRE 269
Query: 260 DDLETCGSPGGLKGRYFWHVREEEFVCEPPLIT-QHTHKLLVLEGQAATLKCKAIGDPSP 318
DDLETC +P L RYFW + EEEF+CEPPLIT Q + LV+EGQA +L+C+A+GDP P
Sbjct: 270 DDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEP 329
Query: 319 LIHWVAPDDRLVGNSSRTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVSIVQ 378
++HWVAPD RL+GNSSRT V +GTLD+ ITT +DSG FTCIA+NAAGEATA VEV +V
Sbjct: 330 VVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVP 389
Query: 379 LPHLSNSTSRTAPPKSRLSDITGSSKTSRGGGGSGGGEPPKSPPERAVLVSEVTTTSALV 438
LP + APP + +T + G G S ER ++ +E+T+ S L+
Sbjct: 390 LPLM-------APPPAAPPPLTEPGSSDIATPGRPGAN--DSAAERRLVAAELTSNSVLI 440
Query: 439 KWSVSKSAPRVKMYQLQYNCSDDEVLIYRMIPASNKAFVVNNLVSGTGYDLCVLAMWDDT 498
+W + P ++MYQ+QYN S D+ L+YRMIP++++ F+VN+L +G YDLCVLA++DD
Sbjct: 441 RWPAQRPVPGIRMYQVQYNSSVDDSLVYRMIPSTSQTFLVNDLAAGRAYDLCVLAVYDDG 500
Query: 499 ATTLTATNIVGCAQFFTKADYPQCQSMHSQILGGTMILVIGGIIVATLLVFIVILMVRYK 558
AT L AT +VGC QF T D C+ + + LGGTMI+ IGG+IVA++LVFIV+LM+RYK
Sbjct: 501 ATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAIGGVIVASVLVFIVLLMIRYK 560
Query: 559 V-----CNHEAPSKMAAAVSNVYSQTNGAQPPPPSSAPAGAPPQGPPKVVVRNELLDFTA 613
V S+ VS+V SQTNGA + A V ++ A
Sbjct: 561 VYGDGDSRRVKGSRSLPRVSHVCSQTNGAGTGAAQAPALPAQDHYEALREVESQAAPAVA 620
Query: 614 SLARASDSSSSSSLGSGEAAGLGRAPWRIPPSAPRPKPSLDRLMGAFASLDLKSQRKEEL 673
A+A ++ ++S+ P+ L R +G A+ L
Sbjct: 621 VEAKAMEAETASA---------------------EPEVVLGRSLGGSAT-------SLCL 652
Query: 674 LDSRTPAGRGAGTSARGHHSDREPLLGPPAARARSLLPLP----LEGKAKRSHSFDMGDF 729
L S +G +A G R L PP + +L +P + ++ +SFD GD+
Sbjct: 653 LPSEETSGE-ESRAAVGPRRSRSGALEPPTSAPPTLALVPGGAAARPRPQQRYSFD-GDY 710
Query: 730 AAAAAGGVVPGGYSPPRKVSNIWTKRS---LSVNGMLLPFEESDL----VGARGTFGSSE 782
G + +S PR+ RS L G E+ DL A F S+E
Sbjct: 711 ------GALFQSHSYPRRARRTKRHRSTPHLDGAGGGAAGEDGDLGLGSARACLAFTSTE 764
Query: 783 WVMESTV 789
W++ESTV
Sbjct: 765 WMLESTV 771
>gi|27363458 leucine rich repeat and fibronectin type III domain
containing 4 [Homo sapiens]
Length = 635
Score = 626 bits (1615), Expect = e-179
Identities = 346/651 (53%), Positives = 430/651 (66%), Gaps = 39/651 (5%)
Query: 8 LLAFGMAFAVVDACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHI 67
LLA G A ACP CVCQNLSESL TLC +GLLFVPP++DRRTVELRL NFI +
Sbjct: 9 LLASGAA-----ACPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQAL 63
Query: 68 SRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQ 127
DF NMTGLVDLTLSRN I+ I +F DLESLRSLHLD NRL LG +LRG VNLQ
Sbjct: 64 GPPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGPVNLQ 123
Query: 128 HLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDH 187
HLI++ NQLG IA AF+DFL +LEDLDLSYNNL +PW + M LH L+LDHNL+D
Sbjct: 124 HLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHNLIDA 183
Query: 188 IAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFGGNPLHCN 247
+ G FA L +L+RLDLTSNRL L PDP+F+R + + A+P PL SF GNPLHCN
Sbjct: 184 LPPGAFAQLGQLSRLDLTSNRLATLAPDPLFSRGRDA--EASP--APLVLSFSGNPLHCN 239
Query: 248 CELLWLRRLERDDDLETCGSPGGLKGRYFWHVREEEFVCEPPLITQHTHKLLVLEGQAAT 307
CELLWLRRL R DDLETC SP GL GRYFW V E EF CEPPLI +HT +L VLEGQ AT
Sbjct: 240 CELLWLRRLARPDDLETCASPPGLAGRYFWAVPEGEFSCEPPLIARHTQRLWVLEGQRAT 299
Query: 308 LKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGTLDIFITTSQDSGAFTCIAANAAGE 367
L+C+A+GDP+P +HWV PDDRLVGNSSR + NGTL+I +T + D+G +TCIA N AGE
Sbjct: 300 LRCRALGDPAPTMHWVGPDDRLVGNSSRARAFPNGTLEIGVTGAGDAGGYTCIATNPAGE 359
Query: 368 ATAMVEVSIVQLPHLSNSTSRTAPPKSRLSDITGSSKTSRGGGGSGGGEPPKSPPERAVL 427
ATA VE+ ++ LPH NS++ P SDI S++T+ G G+ EP AV
Sbjct: 360 ATARVELRVLALPHGGNSSAEGGRPGP--SDIAASARTAAEGEGTLESEP-------AVQ 410
Query: 428 VSEVTTTSALVKWSVSKSAPRVKMYQLQYNCSDDEVLIYRMIPASNKAFVVNNLVSGTGY 487
V+EVT TS LV W + A V M+Q+QYN S+DE LIYR++PAS+ F++ +LV G Y
Sbjct: 411 VTEVTATSGLVSWGPGRPADPVWMFQIQYNSSEDETLIYRIVPASSHHFLLKHLVPGADY 470
Query: 488 DLCVLAMWDDTA-TTLTATNIVGCAQFFTKADYPQCQSMHSQILGGTMILVIGGIIVATL 546
DLC+LA+ + LTAT ++GCA F T P C ++ + +LGGT+ + +GG++VA L
Sbjct: 471 DLCLLALSPAAGPSDLTATRLLGCAHFSTLPASPLCHALQAHVLGGTLTVAVGGVLVAAL 530
Query: 547 LVFIVILMVRYKVCNHEAPSKMAAAVSNVYSQTNGAQPPPPSSAPAGAPPQGPPKVVVRN 606
LVF V L+VR + + ++ +S+V SQTNG PS P PP+ PP R+
Sbjct: 531 LVFTVALLVRGRGAGN---GRLPLKLSHVQSQTNGG----PSPTPKAHPPRSPPPRPQRS 583
Query: 607 ELLD------------FTASLARASDSSSSSSLGSGEAAGLGRAPWRIPPS 645
LD + AR S S LG+G G+G + R+ S
Sbjct: 584 CSLDLGDAGCYGYARRLGGAWARRSHSVHGGLLGAG-CRGVGGSAERLEES 633
Score = 38.5 bits (88), Expect = 0.024
Identities = 39/116 (33%), Positives = 49/116 (42%), Gaps = 28/116 (24%)
Query: 681 GRGAGT-------SARGHHSDREPLLGPPAARARSLLPLPLEGKAKRSHSFDMGDFAAAA 733
GRGAG S ++ P P A RS P P +RS S D+GD
Sbjct: 541 GRGAGNGRLPLKLSHVQSQTNGGPSPTPKAHPPRSPPPRP-----QRSCSLDLGD----- 590
Query: 734 AGGVVPGGYSPPRKVSNIWTKRSLSVNGMLLPFEESDLVGARGTFGSSEWVMESTV 789
G Y R++ W +RS SV+G LL G RG GS+E + ES V
Sbjct: 591 -----AGCYGYARRLGGAWARRSHSVHGGLLG------AGCRGVGGSAERLEESVV 635
>gi|13375646 leucine rich repeat and fibronectin type III domain
containing 3 [Homo sapiens]
Length = 628
Score = 607 bits (1564), Expect = e-173
Identities = 310/585 (52%), Positives = 398/585 (68%), Gaps = 8/585 (1%)
Query: 16 AVVDACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANM 75
A CP+ C CQ S L LCP GLLFVPP +DRR ELRL NFI + R+D ANM
Sbjct: 23 ATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIASVRRRDLANM 82
Query: 76 TGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQ 135
TGL+ L+LSRNTI H+ +F DL +LR+LHLD NRL SLGE LRGLVNL+HLI++NNQ
Sbjct: 83 TGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQ 142
Query: 136 LGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFAD 195
L +A A +D TLEDLDLSYNNL LPW+++ R+ N++ L LDHNLL + G F+
Sbjct: 143 LAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSR 202
Query: 196 LQKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFGGNPLHCNCELLWLRR 255
L KLARLD+TSNRL +PPDP+F+R A A L +FGGNPLHCNCEL+WLRR
Sbjct: 203 LHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRR 262
Query: 256 LERDDDLETCGSPGGLKGRYFWHVREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGD 315
L R+DDLE C SP L GRYFW V EEEFVCEPP++T + L V G+ A L+C+A+GD
Sbjct: 263 LAREDDLEACASPPALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAVGD 322
Query: 316 PSPLIHWVAPDDRLVGNSSRTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVS 375
P P + WV+P RL+GNSSR + NGTL++ +T D G FTCIAANAAGEATA VE++
Sbjct: 323 PEPRVRWVSPQGRLLGNSSRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELT 382
Query: 376 I--VQLPHLSNSTSRTAPPKSRLSDITGSSKTSRGGGGSGGGEPPKSPPERAVLVSEVTT 433
+ P L+NSTS P +T S S + G P +R V V+E
Sbjct: 383 VGPPPPPQLANSTSCDPPRDGDPDALTPPSAASASAKVADTG----PPTDRGVQVTEHGA 438
Query: 434 TSALVKWSVSKSAPRVKMYQLQYNCSDDEVLIYRMIPASNKAFVVNNLVSGTGYDLCVLA 493
T+ALV+W + P ++MYQ+QYN S D++L+YRMIPA +++F++ +L SG YDLCVLA
Sbjct: 439 TAALVQWPDQRPIPGIRMYQIQYNSSADDILVYRMIPAESRSFLLTDLASGRTYDLCVLA 498
Query: 494 MWDDTATTLTATNIVGCAQFFTKADYPQCQSMHSQILGGTMILVIGGIIVATLLVFIVIL 553
+++D+AT LTAT VGCA+F T+ C + H+ LGGTMI+ +GG+IVA++LVFI +L
Sbjct: 499 VYEDSATGLTATRPVGCARFSTEPALRPCGAPHAPFLGGTMIIALGGVIVASVLVFIFVL 558
Query: 554 MVRYKVCNHEAP--SKMAAAVSNVYSQTNGAQPPPPSSAPAGAPP 596
++RYKV + P +K+ A VS+V SQTNGA P P+ AP P
Sbjct: 559 LMRYKVHGGQPPGKAKIPAPVSSVCSQTNGALGPTPTPAPPAPEP 603
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 152 bits (385), Expect = 9e-37
Identities = 128/450 (28%), Positives = 187/450 (41%), Gaps = 87/450 (19%)
Query: 20 ACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLV 79
+CP C C N + + +C + L VP I T L L N I I F ++ L
Sbjct: 56 SCPVACSCSNQASRV--ICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLE 113
Query: 80 DLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNN----- 134
L LS+N + I+ +F L SL +L L NRL ++ L L+ L + NN
Sbjct: 114 ILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESI 173
Query: 135 --------------------QLGGIADEAFEDF---------------------LLTLED 153
+L I++ AFE L+ LE+
Sbjct: 174 PSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEE 233
Query: 154 LDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLP 213
L+LS N L + S + + +L +L L H + I F DL+ L L+L+ N L LP
Sbjct: 234 LELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLP 293
Query: 214 PDPIFARSQASALTATPFAPPLSFSFGGNPLHCNCELLWLRRLERD------DDLETCGS 267
D TP NP HCNC++LWL ++ C +
Sbjct: 294 HD-----------LFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHA 342
Query: 268 PGGLKGRYFWHVREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDD 327
P GLKGRY + + F C P+I + L V EG AA LKC+ G ++W+ P+
Sbjct: 343 PAGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNG 401
Query: 328 RLVGNSS---RTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVSIVQLPHLSN 384
L+ + S R +V +GTL+ T QD+G +TC+ N+AG TA +++ +
Sbjct: 402 TLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAV----- 456
Query: 385 STSRTAPPKSRLSDITGSSKTSRGGGGSGG 414
D + T GGGG GG
Sbjct: 457 -------------DPVAAGGTGSGGGGPGG 473
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 142 bits (358), Expect = 1e-33
Identities = 123/435 (28%), Positives = 181/435 (41%), Gaps = 78/435 (17%)
Query: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVD 80
CP C C N + +C K L VP I T L L N I I F ++ L
Sbjct: 47 CPSVCSCSNQFSKV--ICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEI 104
Query: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNN------ 134
L LSRN I I+ +F L +L +L L NRL ++ L L+ L + NN
Sbjct: 105 LQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIP 164
Query: 135 -------------------QLGGIADEAFEDF---------------------LLTLEDL 154
+L I++ AFE L+ L++L
Sbjct: 165 SYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDEL 224
Query: 155 DLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPP 214
DLS N+L + S + +++L +L + + + I F +LQ L ++L N L LP
Sbjct: 225 DLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPH 284
Query: 215 DPIFARSQASALTATPFAPPLSFSFGGNPLHCNCELLWLRRLERD------DDLETCGSP 268
D TP NP +CNC++LWL +D C +P
Sbjct: 285 D-----------LFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTP 333
Query: 269 GGLKGRYFWHVREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDR 328
LKGRY + + F C P+I + L V EG AA LKC+A + W+ P+
Sbjct: 334 PNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRA-STSLTSVSWITPNGT 392
Query: 329 LVGNSS---RTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVSIVQLPHLSNS 385
++ + + R AV +GTL+ T QD+G +TC+ +N+ G TA + N
Sbjct: 393 VMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATL---------NV 443
Query: 386 TSRTAPPKSRLSDIT 400
T+ T P S S +T
Sbjct: 444 TAATTTPFSYFSTVT 458
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 140 bits (353), Expect = 5e-33
Identities = 103/346 (29%), Positives = 164/346 (47%), Gaps = 29/346 (8%)
Query: 57 LRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLG 116
L +G N +++IS + F+ + L LTL + ++ + + L SL SLHL + ++
Sbjct: 158 LEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMP 217
Query: 117 EDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLH 176
+ L +L+HL ++ L + A + L L L ++ NL +P+ + + +V L
Sbjct: 218 VYAFKRLFHLKHLEIDYWPLLDMMP-ANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLT 276
Query: 177 QLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPI----------FARSQASAL 226
L+L +N + I G F+DL +L L + +L+ + P +++ L
Sbjct: 277 HLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETL 336
Query: 227 TATPFAPPLSF---SFGGNPLHCNCELLWLRRLERDDDLE------TCGSPGGLKGRYFW 277
F+ P + S NPL C+C LLW+ L+R L+ C P ++ R F
Sbjct: 337 EENVFSSPRALEVLSINNNPLACDCRLLWI--LQRQPTLQFGGQQPMCAGPDTIRERSFK 394
Query: 278 HVREEE----FVCEPPLITQHT-HKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGN 332
F C+ P I + LLV EGQ L+C A GDP P+I WV P R +
Sbjct: 395 DFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITT 454
Query: 333 SS--RTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVSI 376
S R V +GTL+I QDSG + CIA+NAAG T +++
Sbjct: 455 KSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTV 500
Score = 76.6 bits (187), Expect = 8e-14
Identities = 54/193 (27%), Positives = 98/193 (50%), Gaps = 3/193 (1%)
Query: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVD 80
CP C C ++S+ C + L+ +P I T L L N + ++ ++F + L +
Sbjct: 28 CPARCECSAQNKSVS--CHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEE 85
Query: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140
+ LS N I++++P +F +L +LRSL L NRL + GL NL L ++ N++ +
Sbjct: 86 IDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILL 145
Query: 141 DEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLA 200
D F+D L L+ L++ N+L + + +++L QL+L+ L + + L+ L
Sbjct: 146 DYMFQD-LHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLI 204
Query: 201 RLDLTSNRLQKLP 213
L L + +P
Sbjct: 205 SLHLKHLNINNMP 217
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 139 bits (350), Expect = 1e-32
Identities = 103/346 (29%), Positives = 160/346 (46%), Gaps = 29/346 (8%)
Query: 57 LRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLG 116
L +G N ++ +SR+ FA + L +LTL R ++ + S L SL +L L + SL
Sbjct: 155 LEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLE 214
Query: 117 EDTLRGLVNLQHLIVNNNQLGGIADEAFEDFL--LTLEDLDLSYNNLHGLPWDSVRRMVN 174
+ R L L HL ++N L +E L L L L +++ N+ +P ++R +
Sbjct: 215 DQNFRRLPGLLHLEIDNWPL---LEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAH 271
Query: 175 LHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQ----------AS 224
L L+L HN + + G+F DL +L L L L + P Q S
Sbjct: 272 LTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLS 331
Query: 225 ALTATPFAPPLSFS---FGGNPLHCNCELLWL----RRLERDDDLETCGSPGGLKGRYFW 277
L + F + GNPL C+C LLW+ + L D L C +P ++G
Sbjct: 332 TLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLPACATPAEVRGDALR 391
Query: 278 HVRE----EEFVCEPPLITQ-HTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGN 332
++ + E FVC P I + ++ G+ C+A G+P+P + WV P R V
Sbjct: 392 NLPDSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTA 451
Query: 333 SS--RTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVSI 376
+S R V GTL+I QDSG +TC+A+NA G T +++
Sbjct: 452 TSAGRARVLPGGTLEIQDARPQDSGTYTCVASNAGGNDTYFATLTV 497
Score = 71.2 bits (173), Expect = 3e-12
Identities = 59/207 (28%), Positives = 89/207 (42%), Gaps = 25/207 (12%)
Query: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVD 80
CP C C + ++ C + L VP I T L L N I ++ D A + L +
Sbjct: 25 CPARCECTVQTRAVA--CTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEE 82
Query: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140
L LS N I+H++P +F +L LR L L N+L + L NL L ++ N+L +
Sbjct: 83 LDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILL 142
Query: 141 DEAFEDF-----------------------LLTLEDLDLSYNNLHGLPWDSVRRMVNLHQ 177
D F+D LL LE+L L NL L +S+ + +L
Sbjct: 143 DYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGA 202
Query: 178 LSLDHNLLDHIAEGTFADLQKLARLDL 204
L L H + + + F L L L++
Sbjct: 203 LRLRHLAIASLEDQNFRRLPGLLHLEI 229
Score = 44.7 bits (104), Expect = 3e-04
Identities = 36/107 (33%), Positives = 49/107 (45%), Gaps = 1/107 (0%)
Query: 103 RSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLH 162
R L L NR+ L L L L+ L ++ N + + AF + L L L L N L
Sbjct: 57 RLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFAN-LPRLRVLRLRGNQLK 115
Query: 163 GLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRL 209
+P R+ NL L L N L + + TF DL L RL++ N L
Sbjct: 116 LIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDL 162
Score = 40.4 bits (93), Expect = 0.006
Identities = 23/67 (34%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
Query: 154 LDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLP 213
L+LS N + L + + L +L L N + H+ G FA+L +L L L N+L+ +P
Sbjct: 59 LELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIP 118
Query: 214 PDPIFAR 220
P +F R
Sbjct: 119 PG-VFTR 124
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 127 bits (319), Expect = 4e-29
Identities = 101/346 (29%), Positives = 153/346 (44%), Gaps = 56/346 (16%)
Query: 30 LSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVDLTLSRNTIS 89
+++ G CPS+ L F R TV ++ + A T ++DL +R I
Sbjct: 28 VAQKPGAGCPSRCLCF------RTTVRCM----HLLLEAVPAVAPQTSILDLRFNR--IR 75
Query: 90 HIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLL 149
IQP +F L +L +L L++N++ + L NL++L + N++ I +AF+ L
Sbjct: 76 EIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKG-LA 134
Query: 150 TLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRL 209
+LE L L +N + L DS + + L +L L +N + H+ GTF L+ + RL L SN L
Sbjct: 135 SLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTL 194
Query: 210 QKLPPDPIFARSQASALTATPFAPPLSFSFGGNPLHCNCELLWLRRLERD-------DDL 262
HC+CE+LWL L +
Sbjct: 195 -----------------------------------HCDCEILWLADLLKTYAESGNAQAA 219
Query: 263 ETCGSPGGLKGRYFWHVREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHW 322
C P ++GR + EE CE P IT V G C+A G+P P I W
Sbjct: 220 AICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIW 279
Query: 323 VAPDDRL-VGNSSRTAVYDNGTLDIFITTSQDSGAFTCIAANAAGE 367
+ ++ L + SR + D+GTL I T D G + C+A N AGE
Sbjct: 280 LRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGE 325
Score = 84.3 bits (207), Expect = 4e-16
Identities = 107/416 (25%), Positives = 157/416 (37%), Gaps = 68/416 (16%)
Query: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVD 80
CP C+C + L LL P + +T L L N I I F + L
Sbjct: 36 CPSRCLCFRTTVRCMHL-----LLEAVPAVAPQTSILDLRFNRIREIQPGAFRRLRNLNT 90
Query: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140
L L+ N I I +F DLE+L+ L+L N + S+ +GL +L+ L ++ NQ+ +
Sbjct: 91 LLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLD 150
Query: 141 DEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLA 200
++F+ L LE L L N + L + + ++ +L LD N L E + L L
Sbjct: 151 PDSFQH-LPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILW--LADLL 207
Query: 201 RLDLTSNRLQKLPPDPIFARSQA-SALTATP-----------FAPPLSFSFGGNPLHCNC 248
+ S Q R Q S T TP P + GN ++ C
Sbjct: 208 KTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTC 267
Query: 249 --------ELLWLRR-------------------------LERDDDLETCGSP---GGLK 272
E++WLR E D + C + G +K
Sbjct: 268 RAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVK 327
Query: 273 G-----RYFWHVREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDD 327
RYF FV +P Q+T VL G++ TL+C A G P P I W D
Sbjct: 328 TQEVTLRYFGSPARPTFVIQP----QNTE---VLVGESVTLECSATGHPPPRISWTRGDR 380
Query: 328 RLVGNSSRTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVSIVQLPHLS 383
+ R + +G L I DSG + C A N A + + LP +
Sbjct: 381 TPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFT 436
Score = 45.8 bits (107), Expect = 2e-04
Identities = 26/88 (29%), Positives = 39/88 (44%), Gaps = 1/88 (1%)
Query: 289 PLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGTLDIFI 348
P T +V+EGQ +C+A G+P P+I W +L R V +GTL I
Sbjct: 433 PQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQL-SVDRRHLVLSSGTLRISG 491
Query: 349 TTSQDSGAFTCIAANAAGEATAMVEVSI 376
D G + C A N G + +++
Sbjct: 492 VALHDQGQYECQAVNIIGSQKVVAHLTV 519
Score = 38.9 bits (89), Expect = 0.019
Identities = 25/83 (30%), Positives = 38/83 (45%), Gaps = 2/83 (2%)
Query: 303 GQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGTLDIFITTSQDSGAFTCIAA 362
G L C + G+P P I W D V S + + G L I D+G + C+A
Sbjct: 539 GANVQLPCSSQGEPEPAITW-NKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVAR 597
Query: 363 NAAGEATAMVEVSIVQLPHLSNS 385
N G A+ + +S V +P +S +
Sbjct: 598 NTIGSASVSMVLS-VNVPDVSRN 619
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 127 bits (318), Expect = 5e-29
Identities = 104/377 (27%), Positives = 155/377 (41%), Gaps = 57/377 (15%)
Query: 56 ELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSL 115
+L +G N ++ ++ FA + L LTL R +S + + L +L +L L + L
Sbjct: 160 KLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRL 219
Query: 116 GEDTLRGL------------------------VNLQHLIVNNNQLGGIADEAFEDFLLTL 151
LRGL +NL L + L + +A L L
Sbjct: 220 PAGALRGLGQLKELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYH-LSFL 278
Query: 152 EDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQK 211
LDLS N + +P + +V L +L L L IA F L LD+ N LQ
Sbjct: 279 RVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQT 338
Query: 212 LPPDPIFARSQASALTATPFAPPL-SFSFGGNPLHCNCELLWLRRLERDDDL----ETCG 266
L TA P L + GNPL C+C LLWL RL R D C
Sbjct: 339 LEE------------TAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACA 386
Query: 267 SPGGLKGRYFWHVRE----EEFVCEPPLITQHTHKLLVLE-GQAATLKCKAIGDPSPLIH 321
P ++G+ + F C+P LI + + ++ E G A C GDP+P +
Sbjct: 387 GPHHVQGKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVS 446
Query: 322 WVAPDDRLVGNSSRTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVSIVQLPH 381
W+ P +G + R V ++GTL+I +D GA+ C+ +N AG + + ++Q+
Sbjct: 447 WMRPHGAWLGRAGRVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQV-- 504
Query: 382 LSNSTSRTAPPKSRLSD 398
PP LSD
Sbjct: 505 --------EPPNGTLSD 513
Score = 66.2 bits (160), Expect = 1e-10
Identities = 59/207 (28%), Positives = 94/207 (45%), Gaps = 3/207 (1%)
Query: 20 ACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLV 79
+CP C C S+ LC + L VP + T L L GN + + + + ++ L
Sbjct: 30 SCPAVCDCT--SQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQ 87
Query: 80 DLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGI 139
+L LS N +S ++P +F L+SL +L L NRL +G GL L L + NQ+
Sbjct: 88 ELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLF 147
Query: 140 ADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKL 199
D AF + L +L+ L++ N+L + + + L L+L+ L + A L L
Sbjct: 148 LDGAFGE-LGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPAL 206
Query: 200 ARLDLTSNRLQKLPPDPIFARSQASAL 226
L L + +LP + Q L
Sbjct: 207 VALRLRELDIGRLPAGALRGLGQLKEL 233
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 125 bits (314), Expect = 2e-28
Identities = 109/407 (26%), Positives = 174/407 (42%), Gaps = 54/407 (13%)
Query: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVD 80
CP C C N + +C +GL VP I T L L N I I F ++ L
Sbjct: 46 CPSVCSCSNQFSKV--VCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEV 103
Query: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140
L L RN+I I+ +F L SL +L L N L + L L+ L + NN + I
Sbjct: 104 LQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIP 163
Query: 141 DEAFE------------------------DFLLTLEDLDLSYNNLHGLPWDSVRRMVNLH 176
AF + L L+ L+L N+ +P ++ +V L
Sbjct: 164 SYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMP--NLTPLVGLE 221
Query: 177 QLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPI----------FARSQASAL 226
+L + N I G+F L L +L + ++++ + + A + S+L
Sbjct: 222 ELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSL 281
Query: 227 TATPFAP---PLSFSFGGNPLHCNCELLWLRRLERD---DDLETCG---SPGGLKGRYFW 277
F P + NP +C+C++LWL R+ + CG +P ++GRY
Sbjct: 282 PHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLV 341
Query: 278 HVREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSS--- 334
V + F C P I L + EG+ A LKC+ P + W+ P+ ++ ++S
Sbjct: 342 EVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRT--PPMSSVKWLLPNGTVLSHASRHP 399
Query: 335 RTAVYDNGTLDIFITTSQDSGAFTCIAANAAG--EATAMVEVSIVQL 379
R +V ++GTL+ D+G +TC+ N AG A+A + VS +L
Sbjct: 400 RISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAEL 446
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 124 bits (312), Expect = 3e-28
Identities = 104/356 (29%), Positives = 147/356 (41%), Gaps = 73/356 (20%)
Query: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVD 80
CP C+C + L +L P + ++T L L N I I F + L
Sbjct: 24 CPSRCLCFKSTVRCMHL-----MLDHIPQVPQQTTVLDLRFNRIREIPGSAFKKLKNLNT 78
Query: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140
L L+ N I I +F LE+L L+L N + +L + T +GL++L+HL ++ NQL +
Sbjct: 79 LLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQ 138
Query: 141 DEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLA 200
E F D L L +L L +N L I G+F++L L
Sbjct: 139 PETFGDLL-------------------------RLERLFLHNNKLSKIPAGSFSNLDSLK 173
Query: 201 RLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFGGNPLHCNCELLWLRRL---- 256
RL L SN L C+C+L+WL L
Sbjct: 174 RLRLDSNALV-----------------------------------CDCDLMWLGELLQGF 198
Query: 257 ---ERDDDLETCGSPGGLKGRYFWHVREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAI 313
TC P L GR V EEF C+ P IT + V G C+A
Sbjct: 199 AQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAE 258
Query: 314 GDPSPLIHWVAPDDRL-VGNSSRTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEA 368
G+P P I W+ + L + + +R V+D+GTL I T D G + C+A N+AGEA
Sbjct: 259 GNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEA 314
Score = 50.1 bits (118), Expect = 8e-06
Identities = 95/375 (25%), Positives = 135/375 (36%), Gaps = 77/375 (20%)
Query: 70 QDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPS------LGEDTLRGL 123
+ F ++ L L L N +S I SF +L+SL+ L LDSN L LGE L+G
Sbjct: 140 ETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGE-LLQGF 198
Query: 124 VNLQHLIVNNN-----QLGG--IADEAFEDF-----LLTLEDLDL---SYNNLH------ 162
H +L G +A E+F +T E D+ S N ++
Sbjct: 199 AQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAE 258
Query: 163 GLPWDSVRRMVNLHQLSL-DHNLLDHIAEGTF----------ADLQKLARLDLTSNRLQK 211
G P + + N H L L D L+ +GT Q +AR + Q
Sbjct: 259 GNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQS 318
Query: 212 -------LPPDPIFARSQASALTATPFAPPLSFSFGGNPLHCNCELLWLRRLERDDDLET 264
LP P F + L G+P + + W R D+ LE
Sbjct: 319 AMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHP---HPLITWTR----DNGLEL 371
Query: 265 CGS-----PGGL---------KGRYFWHVREEE---------FVCEPPLITQHTHKLLVL 301
GS GL GR+ H V PP T +VL
Sbjct: 372 DGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVL 431
Query: 302 EGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGTLDIFITTSQDSGAFTCIA 361
E A C+A G+P P+I W +L T V +GTL I D G + C A
Sbjct: 432 EEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHT-VLSSGTLRIDRAAQHDQGQYECQA 490
Query: 362 ANAAGEATAMVEVSI 376
++ G V++++
Sbjct: 491 VSSLGVKKVSVQLTV 505
Score = 43.1 bits (100), Expect = 0.001
Identities = 25/90 (27%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 290 LITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGTLDIFIT 349
+ TQ V G+ + C A G+P P+I W ++ S + V D GTL I+
Sbjct: 512 VFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQIT-ESGKFHVDDEGTLTIYDA 570
Query: 350 TSQDSGAFTCIAANAAGEATAMVEVSIVQL 379
D G + C+A N+ G A + +++ +
Sbjct: 571 GFPDQGRYECVARNSFGLAVTNMFLTVTAI 600
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 110 bits (275), Expect = 5e-24
Identities = 94/359 (26%), Positives = 156/359 (43%), Gaps = 31/359 (8%)
Query: 57 LRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLG 116
L +G N +++IS + F+ + L LTL + ++ I + L L L L + ++
Sbjct: 172 LEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIR 231
Query: 117 EDTLRGLVNLQHLIVNN-NQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNL 175
+ + + L L+ L +++ L + + L L L +++ NL +P+ +VR +V L
Sbjct: 232 DYSFKRLYRLKVLEISHWPYLDTMTPNCL--YGLNLTSLSITHCNLTAVPYLAVRHLVYL 289
Query: 176 HQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASALTA-----TP 230
L+L +N + I +L +L + L +L + P + L T
Sbjct: 290 RFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTT 349
Query: 231 FAPPLSFSFGG--------NPLHCNCELLWLRR----LERDDDLETCGSPGGLKGRYFWH 278
+ S G NPL C+C LLW+ R L + TC +P ++G+ F
Sbjct: 350 LEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKD 409
Query: 279 VRE----EEFVCEPPLITQH-THKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNS 333
+ F C I ++ V EG C+A GDP P I W++P LV
Sbjct: 410 FPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAK 469
Query: 334 S--RTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVSI----VQLPHLSNST 386
S R V+ +GTL++ QD+G + CIAANA G + + + PH N T
Sbjct: 470 SNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKT 528
Score = 79.7 bits (195), Expect = 1e-14
Identities = 67/241 (27%), Positives = 111/241 (46%), Gaps = 32/241 (13%)
Query: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVD 80
CP C C ++ LC K + VP I T L LG N I +++ +FA+ L +
Sbjct: 42 CPPRCECS--AQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEE 99
Query: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140
L L+ N +S ++P +F +L +LR+L L SNRL + GL NL L ++ N++ +
Sbjct: 100 LELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILL 159
Query: 141 DEAFEDF-----------------------LLTLEDLDLSYNNLHGLPWDSVRRMVNLHQ 177
D F+D L +LE L L NL +P +++ + L
Sbjct: 160 DYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIV 219
Query: 178 LSLDHNLLDHIAEGTFADLQKLARLDLTS-NRLQKLPPDPIFARSQASA------LTATP 230
L L H ++ I + +F L +L L+++ L + P+ ++ + S LTA P
Sbjct: 220 LRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVP 279
Query: 231 F 231
+
Sbjct: 280 Y 280
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 108 bits (269), Expect = 3e-23
Identities = 122/556 (21%), Positives = 212/556 (38%), Gaps = 119/556 (21%)
Query: 62 NFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLR 121
N + + + + ++ L +L ++ N +S I P +F+ L +L LHL+SNRL +
Sbjct: 126 NKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFD 185
Query: 122 GLVNLQHLIVNNNQLGGIADEAFEDF-----------------------LLTLEDLDLSY 158
L NL+ L++ N + I D F+ L LE +
Sbjct: 186 ALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYD 245
Query: 159 NNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFA------------------------ 194
N L +P +++++VNL L L+ N ++ I G F+
Sbjct: 246 NRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAV 305
Query: 195 -DLQKLARLDLTSN-RLQKLPPDPIFARSQASALTATPFA------------PPL-SFSF 239
+L L +++ T+N RL + P+ F + +L A P L S
Sbjct: 306 DNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISI 365
Query: 240 GGNPLHCNCELLWLR------RLERDDDLETCGSPGGLKGRYF--WHVREEEFVCEPPLI 291
NP+ C+C + W+ R D L C P +G+ H R+ +C P +
Sbjct: 366 HSNPIRCDCVIRWMNMNKTNIRFMEPDSL-FCVDPPEFQGQNVRQVHFRDMMEICLPLIA 424
Query: 292 TQHTHKLLVLE-GQAATLKCKAIGDPSPLIHWVAPD-DRLVGN--SSRTAVYDNGTLDIF 347
+ L +E G + C+A +P P I+W+ P +L+ N + + V+ GTLDI
Sbjct: 425 PESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDIN 484
Query: 348 ITTSQDSGAFTCIAANAAGEATAMVEVSIVQLPHLSNSTSRTAPPKSRLSDITGSSKTSR 407
T ++ G +TCIA N G A KS + + GS
Sbjct: 485 GVTPKEGGLYTCIATNLVG-----------------------ADLKSVMIKVDGSFPQDN 521
Query: 408 GGGGSGGGEPPKSPPERAVLVSEVTTTSALVKWSVSKSAPRVKMYQLQY-NCSDDEVLIY 466
G + + + ++ S LV W S + + + +
Sbjct: 522 NGSLN-------------IKIRDIQANSVLVSWKASSKILKSSVKWTAFVKTENSHAAQS 568
Query: 467 RMIPASNKAFVVNNLVSGTGYDLCVLAMWDDTATTLTATNIVGCAQFFTKADYPQCQSMH 526
IP+ K + + +L T Y +C+ T+ N C TK +P Q +
Sbjct: 569 ARIPSDVKVYNLTHLNPSTEYKICI------DIPTIYQKNRKKCVNVTTKGLHPD-QKEY 621
Query: 527 SQILGGTMILVIGGII 542
+ T++ +GG++
Sbjct: 622 EKNNTTTLMACLGGLL 637
Score = 64.3 bits (155), Expect = 4e-10
Identities = 62/208 (29%), Positives = 90/208 (43%), Gaps = 15/208 (7%)
Query: 21 CPKYCVCQN---------LSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQ- 70
CP+ C C+ E+ C GLL P + T L L N I I
Sbjct: 29 CPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
Query: 71 DF-ANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHL 129
DF N+TGL LS+N +S + + + L S++L+ N+L L E L L NLQ L
Sbjct: 89 DFPVNLTGL---DLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQEL 145
Query: 130 IVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIA 189
+N+N L I+ AF L L L L+ N L + + NL L + N + I
Sbjct: 146 YINHNLLSTISPGAFIG-LHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIK 204
Query: 190 EGTFADLQKLARLDLTSNRLQKLPPDPI 217
+ F L L L + L ++P + +
Sbjct: 205 DMNFKPLINLRSLVIAGINLTEIPDNAL 232
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 108 bits (269), Expect = 3e-23
Identities = 122/556 (21%), Positives = 212/556 (38%), Gaps = 119/556 (21%)
Query: 62 NFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLR 121
N + + + + ++ L +L ++ N +S I P +F+ L +L LHL+SNRL +
Sbjct: 126 NKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFD 185
Query: 122 GLVNLQHLIVNNNQLGGIADEAFEDF-----------------------LLTLEDLDLSY 158
L NL+ L++ N + I D F+ L LE +
Sbjct: 186 ALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYD 245
Query: 159 NNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFA------------------------ 194
N L +P +++++VNL L L+ N ++ I G F+
Sbjct: 246 NRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAV 305
Query: 195 -DLQKLARLDLTSN-RLQKLPPDPIFARSQASALTATPFA------------PPL-SFSF 239
+L L +++ T+N RL + P+ F + +L A P L S
Sbjct: 306 DNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISI 365
Query: 240 GGNPLHCNCELLWLR------RLERDDDLETCGSPGGLKGRYF--WHVREEEFVCEPPLI 291
NP+ C+C + W+ R D L C P +G+ H R+ +C P +
Sbjct: 366 HSNPIRCDCVIRWMNMNKTNIRFMEPDSL-FCVDPPEFQGQNVRQVHFRDMMEICLPLIA 424
Query: 292 TQHTHKLLVLE-GQAATLKCKAIGDPSPLIHWVAPD-DRLVGN--SSRTAVYDNGTLDIF 347
+ L +E G + C+A +P P I+W+ P +L+ N + + V+ GTLDI
Sbjct: 425 PESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDIN 484
Query: 348 ITTSQDSGAFTCIAANAAGEATAMVEVSIVQLPHLSNSTSRTAPPKSRLSDITGSSKTSR 407
T ++ G +TCIA N G A KS + + GS
Sbjct: 485 GVTPKEGGLYTCIATNLVG-----------------------ADLKSVMIKVDGSFPQDN 521
Query: 408 GGGGSGGGEPPKSPPERAVLVSEVTTTSALVKWSVSKSAPRVKMYQLQY-NCSDDEVLIY 466
G + + + ++ S LV W S + + + +
Sbjct: 522 NGSLN-------------IKIRDIQANSVLVSWKASSKILKSSVKWTAFVKTENSHAAQS 568
Query: 467 RMIPASNKAFVVNNLVSGTGYDLCVLAMWDDTATTLTATNIVGCAQFFTKADYPQCQSMH 526
IP+ K + + +L T Y +C+ T+ N C TK +P Q +
Sbjct: 569 ARIPSDVKVYNLTHLNPSTEYKICI------DIPTIYQKNRKKCVNVTTKGLHPD-QKEY 621
Query: 527 SQILGGTMILVIGGII 542
+ T++ +GG++
Sbjct: 622 EKNNTTTLMACLGGLL 637
Score = 64.3 bits (155), Expect = 4e-10
Identities = 62/208 (29%), Positives = 90/208 (43%), Gaps = 15/208 (7%)
Query: 21 CPKYCVCQN---------LSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQ- 70
CP+ C C+ E+ C GLL P + T L L N I I
Sbjct: 29 CPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
Query: 71 DF-ANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHL 129
DF N+TGL LS+N +S + + + L S++L+ N+L L E L L NLQ L
Sbjct: 89 DFPVNLTGL---DLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQEL 145
Query: 130 IVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIA 189
+N+N L I+ AF L L L L+ N L + + NL L + N + I
Sbjct: 146 YINHNLLSTISPGAFIG-LHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIK 204
Query: 190 EGTFADLQKLARLDLTSNRLQKLPPDPI 217
+ F L L L + L ++P + +
Sbjct: 205 DMNFKPLINLRSLVIAGINLTEIPDNAL 232
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 108 bits (269), Expect = 3e-23
Identities = 122/556 (21%), Positives = 212/556 (38%), Gaps = 119/556 (21%)
Query: 62 NFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLR 121
N + + + + ++ L +L ++ N +S I P +F+ L +L LHL+SNRL +
Sbjct: 126 NKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFD 185
Query: 122 GLVNLQHLIVNNNQLGGIADEAFEDF-----------------------LLTLEDLDLSY 158
L NL+ L++ N + I D F+ L LE +
Sbjct: 186 ALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYD 245
Query: 159 NNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFA------------------------ 194
N L +P +++++VNL L L+ N ++ I G F+
Sbjct: 246 NRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAV 305
Query: 195 -DLQKLARLDLTSN-RLQKLPPDPIFARSQASALTATPFA------------PPL-SFSF 239
+L L +++ T+N RL + P+ F + +L A P L S
Sbjct: 306 DNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISI 365
Query: 240 GGNPLHCNCELLWLR------RLERDDDLETCGSPGGLKGRYF--WHVREEEFVCEPPLI 291
NP+ C+C + W+ R D L C P +G+ H R+ +C P +
Sbjct: 366 HSNPIRCDCVIRWMNMNKTNIRFMEPDSL-FCVDPPEFQGQNVRQVHFRDMMEICLPLIA 424
Query: 292 TQHTHKLLVLE-GQAATLKCKAIGDPSPLIHWVAPD-DRLVGN--SSRTAVYDNGTLDIF 347
+ L +E G + C+A +P P I+W+ P +L+ N + + V+ GTLDI
Sbjct: 425 PESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDIN 484
Query: 348 ITTSQDSGAFTCIAANAAGEATAMVEVSIVQLPHLSNSTSRTAPPKSRLSDITGSSKTSR 407
T ++ G +TCIA N G A KS + + GS
Sbjct: 485 GVTPKEGGLYTCIATNLVG-----------------------ADLKSVMIKVDGSFPQDN 521
Query: 408 GGGGSGGGEPPKSPPERAVLVSEVTTTSALVKWSVSKSAPRVKMYQLQY-NCSDDEVLIY 466
G + + + ++ S LV W S + + + +
Sbjct: 522 NGSLN-------------IKIRDIQANSVLVSWKASSKILKSSVKWTAFVKTENSHAAQS 568
Query: 467 RMIPASNKAFVVNNLVSGTGYDLCVLAMWDDTATTLTATNIVGCAQFFTKADYPQCQSMH 526
IP+ K + + +L T Y +C+ T+ N C TK +P Q +
Sbjct: 569 ARIPSDVKVYNLTHLNPSTEYKICI------DIPTIYQKNRKKCVNVTTKGLHPD-QKEY 621
Query: 527 SQILGGTMILVIGGII 542
+ T++ +GG++
Sbjct: 622 EKNNTTTLMACLGGLL 637
Score = 64.3 bits (155), Expect = 4e-10
Identities = 62/208 (29%), Positives = 90/208 (43%), Gaps = 15/208 (7%)
Query: 21 CPKYCVCQN---------LSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQ- 70
CP+ C C+ E+ C GLL P + T L L N I I
Sbjct: 29 CPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
Query: 71 DF-ANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHL 129
DF N+TGL LS+N +S + + + L S++L+ N+L L E L L NLQ L
Sbjct: 89 DFPVNLTGL---DLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQEL 145
Query: 130 IVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIA 189
+N+N L I+ AF L L L L+ N L + + NL L + N + I
Sbjct: 146 YINHNLLSTISPGAFIG-LHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIK 204
Query: 190 EGTFADLQKLARLDLTSNRLQKLPPDPI 217
+ F L L L + L ++P + +
Sbjct: 205 DMNFKPLINLRSLVIAGINLTEIPDNAL 232
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 104 bits (260), Expect = 3e-22
Identities = 113/407 (27%), Positives = 176/407 (43%), Gaps = 54/407 (13%)
Query: 55 VELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPS 114
+ L L N + I + F + L L + N + I +F L +LRSL L L
Sbjct: 168 LRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLRE 227
Query: 115 LGEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVN 174
+ + L GL +L+ L +NQL + A E + L+ LDL+ N L + M++
Sbjct: 228 ISDYALEGLQSLESLSFYDNQLARVPRRALEQ-VPGLKFLDLNKNPLQRVGPGDFANMLH 286
Query: 175 LHQLSLDHNLLDHIAEGTFA--DLQKLARLDLTSN-RLQKLPPDPIFARSQASAL----- 226
L +L L +N+ + ++ FA +L +L +LD+T+N RL + P Q L
Sbjct: 287 LKELGL-NNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNN 345
Query: 227 --------TATPFAPPLSFSFGGNPLHCNCELLW-------LRRLERDDDLETCGSPGGL 271
T GNP+ C+C + W +R +E L C P L
Sbjct: 346 ALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTL--CAEPPDL 403
Query: 272 KGRYFWHV--REEEFVCEPPLITQHTH--KLLVLEGQAATLKCKAIGDPSPLIHWVAPDD 327
+ V RE C PLI+ + L V G++ L C+A+ +P P I+WV P
Sbjct: 404 QRLPVREVPFREMTDHC-LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAG 462
Query: 328 -RLVGNSS--RTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVSI-------- 376
RL + R VY GTL++ T++++G +TC+A N G T V V +
Sbjct: 463 LRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRALLQPG 522
Query: 377 ----------VQLPHLSN-STSRTAPPKSRLSDITGSSKTSRGGGGS 412
VQ H + S PP + +++T SS +S G G+
Sbjct: 523 RDEGQGLELRVQETHPYHILLSWVTPPNTVSTNLTWSSASSLRGQGA 569
Score = 85.5 bits (210), Expect = 2e-16
Identities = 63/201 (31%), Positives = 91/201 (45%), Gaps = 10/201 (4%)
Query: 21 CPKYCVCQ---------NLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQD 71
CP C CQ + E+ C L VPP + T L L N I+ + + +
Sbjct: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
Query: 72 FANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIV 131
+ L +L LS+N+ S + F L L SLHL+ N+L L + + GL +LQ L +
Sbjct: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
Query: 132 NNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEG 191
N+NQL IA AF L L L L+ N L + + NL L + N +D I +
Sbjct: 149 NHNQLYRIAPRAFSG-LSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDM 207
Query: 192 TFADLQKLARLDLTSNRLQKL 212
F L L L L L+++
Sbjct: 208 NFRPLANLRSLVLAGMNLREI 228
Score = 37.7 bits (86), Expect = 0.042
Identities = 25/88 (28%), Positives = 43/88 (48%), Gaps = 1/88 (1%)
Query: 127 QHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLD 186
Q L++ +N + + D++ +L L +LDLS N+ + L L L+ N L
Sbjct: 72 QTLLLQSNSIVRV-DQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLT 130
Query: 187 HIAEGTFADLQKLARLDLTSNRLQKLPP 214
+ + +FA L L L L N+L ++ P
Sbjct: 131 RLEDHSFAGLASLQELYLNHNQLYRIAP 158
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 104 bits (260), Expect = 3e-22
Identities = 113/407 (27%), Positives = 176/407 (43%), Gaps = 54/407 (13%)
Query: 55 VELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPS 114
+ L L N + I + F + L L + N + I +F L +LRSL L L
Sbjct: 168 LRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLRE 227
Query: 115 LGEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVN 174
+ + L GL +L+ L +NQL + A E + L+ LDL+ N L + M++
Sbjct: 228 ISDYALEGLQSLESLSFYDNQLARVPRRALEQ-VPGLKFLDLNKNPLQRVGPGDFANMLH 286
Query: 175 LHQLSLDHNLLDHIAEGTFA--DLQKLARLDLTSN-RLQKLPPDPIFARSQASAL----- 226
L +L L +N+ + ++ FA +L +L +LD+T+N RL + P Q L
Sbjct: 287 LKELGL-NNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNN 345
Query: 227 --------TATPFAPPLSFSFGGNPLHCNCELLW-------LRRLERDDDLETCGSPGGL 271
T GNP+ C+C + W +R +E L C P L
Sbjct: 346 ALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTL--CAEPPDL 403
Query: 272 KGRYFWHV--REEEFVCEPPLITQHTH--KLLVLEGQAATLKCKAIGDPSPLIHWVAPDD 327
+ V RE C PLI+ + L V G++ L C+A+ +P P I+WV P
Sbjct: 404 QRLPVREVPFREMTDHC-LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAG 462
Query: 328 -RLVGNSS--RTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVSI-------- 376
RL + R VY GTL++ T++++G +TC+A N G T V V +
Sbjct: 463 LRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRALLQPG 522
Query: 377 ----------VQLPHLSN-STSRTAPPKSRLSDITGSSKTSRGGGGS 412
VQ H + S PP + +++T SS +S G G+
Sbjct: 523 RDEGQGLELRVQETHPYHILLSWVTPPNTVSTNLTWSSASSLRGQGA 569
Score = 85.5 bits (210), Expect = 2e-16
Identities = 63/201 (31%), Positives = 91/201 (45%), Gaps = 10/201 (4%)
Query: 21 CPKYCVCQ---------NLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQD 71
CP C CQ + E+ C L VPP + T L L N I+ + + +
Sbjct: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
Query: 72 FANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIV 131
+ L +L LS+N+ S + F L L SLHL+ N+L L + + GL +LQ L +
Sbjct: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
Query: 132 NNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEG 191
N+NQL IA AF L L L L+ N L + + NL L + N +D I +
Sbjct: 149 NHNQLYRIAPRAFSG-LSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDM 207
Query: 192 TFADLQKLARLDLTSNRLQKL 212
F L L L L L+++
Sbjct: 208 NFRPLANLRSLVLAGMNLREI 228
Score = 37.7 bits (86), Expect = 0.042
Identities = 25/88 (28%), Positives = 43/88 (48%), Gaps = 1/88 (1%)
Query: 127 QHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLD 186
Q L++ +N + + D++ +L L +LDLS N+ + L L L+ N L
Sbjct: 72 QTLLLQSNSIVRV-DQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLT 130
Query: 187 HIAEGTFADLQKLARLDLTSNRLQKLPP 214
+ + +FA L L L L N+L ++ P
Sbjct: 131 RLEDHSFAGLASLQELYLNHNQLYRIAP 158
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 102 bits (253), Expect = 2e-21
Identities = 81/272 (29%), Positives = 112/272 (41%), Gaps = 46/272 (16%)
Query: 20 ACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLV 79
ACP C C + C GL +P +I R T L L GN I I + DFA + L
Sbjct: 33 ACPALCTCTGTTVD----CHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLR 88
Query: 80 DLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGI 139
L L N I ++ +F D++ L L L+ N+L L E L+ NNQ
Sbjct: 89 VLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPE-----------LLFQNNQ---- 133
Query: 140 ADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKL 199
L LDLS N + +P + R +L L LD N + I EG F L+ L
Sbjct: 134 ----------ALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGL 183
Query: 200 ARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPL-SFSFGGNPLHCNCELLWLRRLER 258
L L +N + +P +++ P L +F N L C+C L WL + R
Sbjct: 184 EVLTLNNNNITTIP------------VSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLR 231
Query: 259 DDD----LETCGSPGGLKGRYFWHVREEEFVC 286
C P L+G V++ EF C
Sbjct: 232 QRPTIGLFTQCSGPASLRGLNVAEVQKSEFSC 263
Score = 87.4 bits (215), Expect = 5e-17
Identities = 74/272 (27%), Positives = 106/272 (38%), Gaps = 70/272 (25%)
Query: 20 ACPKYCVCQNLSESLGTL-CPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGL 78
+CP C C N G + C KGL +P ++ E+RL N I I F+ L
Sbjct: 281 SCPAMCTCSN-----GIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKL 335
Query: 79 VDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGG 138
+ LS N I+ I P +F L SL SL L N++ L GL LQ L++N N++
Sbjct: 336 RRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINC 395
Query: 139 IADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQK 198
I +AF+D + NL LSL N + +A+GTF L+
Sbjct: 396 IRPDAFQD-------------------------LQNLSLLSLYDNKIQSLAKGTFTSLRA 430
Query: 199 LARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFGGNPLHCNCELLWLRRLER 258
+ L L NP C+C L WL R
Sbjct: 431 IQTLHLAQ-----------------------------------NPFICDCNLKWLADFLR 455
Query: 259 DDDLET----CGSPGGLKGRYFWHVREEEFVC 286
+ +ET C SP L + ++ ++F C
Sbjct: 456 TNPIETSGARCASPRRLANKRIGQIKSKKFRC 487
Score = 75.5 bits (184), Expect = 2e-13
Identities = 72/273 (26%), Positives = 108/273 (39%), Gaps = 71/273 (26%)
Query: 21 CPKYCVCQ-NLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQD-FANMTGL 78
CP C C+ N+ E C S L +P I + T ELRL N I + F +T L
Sbjct: 513 CPHKCRCEANVVE-----CSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHL 567
Query: 79 VDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGG 138
+ LS N +S I+ +F S+ LHL +N+L S+ RGL L+ L++ NN++
Sbjct: 568 KKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISC 627
Query: 139 IADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQK 198
I +++F + N+ LSL N + ++ G F LQ
Sbjct: 628 IHNDSFTG-------------------------LRNVRLLSLYDNQITTVSPGAFDTLQS 662
Query: 199 LARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFGGNPLHCNCELLWLRRLER 258
L+ L+L + NP +CNC+L WL R
Sbjct: 663 LSTLNLLA-----------------------------------NPFNCNCQLAWLGGWLR 687
Query: 259 DDDLET----CGSPGGLKGRYFWHVREEEFVCE 287
+ T C +P L+ V +F CE
Sbjct: 688 KRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCE 720
Score = 57.0 bits (136), Expect = 7e-08
Identities = 46/194 (23%), Positives = 85/194 (43%), Gaps = 41/194 (21%)
Query: 100 ESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYN 159
+++ L+LD N+ +L L LQ + ++NN++ +++ +F + + L L LSYN
Sbjct: 761 KNVTELYLDGNQF-TLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTN-MSQLTTLILSYN 818
Query: 160 NLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFA 219
L +P + + + +L LSL N + + EG FAD+ L+ L
Sbjct: 819 ALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHL----------------- 861
Query: 220 RSQASALTATPFAPPLSFSFGGNPLHCNCELLWL----RRLERDDDLETCGSPGGLKGRY 275
+ G NPL+C+C L WL + ++ + C P ++G+
Sbjct: 862 ------------------AIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKL 903
Query: 276 FWHVREEEFVCEPP 289
++F C+ P
Sbjct: 904 LLTTPAKKFECQGP 917
Score = 55.1 bits (131), Expect = 3e-07
Identities = 41/139 (29%), Positives = 55/139 (39%), Gaps = 27/139 (19%)
Query: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNF----------------- 63
CP+ C C + C +K L +P I + EL L GN
Sbjct: 734 CPQECACLDTV----VRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLV 789
Query: 64 ------IIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGE 117
I +S F NM+ L L LS N + I P +F L SLR L L N + +L E
Sbjct: 790 DLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQE 849
Query: 118 DTLRGLVNLQHLIVNNNQL 136
+ +L HL + N L
Sbjct: 850 GIFADVTSLSHLAIGANPL 868
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 101 bits (252), Expect = 2e-21
Identities = 84/288 (29%), Positives = 120/288 (41%), Gaps = 51/288 (17%)
Query: 9 LAFGMAFAVVD-----ACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNF 63
L+ G+ A+++ ACP C C + C L VP +I R T L L GN
Sbjct: 11 LSLGLVLAILNKVAPQACPAQCSCSGSTVD----CHGLALRSVPRNIPRNTERLDLNGNN 66
Query: 64 IIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGL 123
I I++ DFA + L L L N IS I+ +F DL+ L L L+ N L E G
Sbjct: 67 ITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGT 126
Query: 124 VNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHN 183
L LDLS N + +P + R V++ L LD+N
Sbjct: 127 AKLYR-------------------------LDLSENQIQAIPRKAFRGAVDIKNLQLDYN 161
Query: 184 LLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPL-SFSFGGN 242
+ I +G F L+ L L L +N + +L ++ + P L +F N
Sbjct: 162 QISCIEDGAFRALRDLEVLTLNNNNITRL------------SVASFNHMPKLRTFRLHSN 209
Query: 243 PLHCNCELL----WLRRLERDDDLETCGSPGGLKGRYFWHVREEEFVC 286
L+C+C L WLR+ R C P L+G V++ EFVC
Sbjct: 210 NLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVC 257
Score = 85.5 bits (210), Expect = 2e-16
Identities = 74/270 (27%), Positives = 107/270 (39%), Gaps = 68/270 (25%)
Query: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVD 80
CP C C N C KGL +P ++ E+RL N I I F+ L
Sbjct: 273 CPAACTCSNNIVD----CRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRR 328
Query: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140
+ LS N IS + P +F L SL SL L N++ L + GL +LQ L++N N++ +
Sbjct: 329 IDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLR 388
Query: 141 DEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLA 200
+AF+D LH NL+ LSL N L IA+GTF+ L+ +
Sbjct: 389 VDAFQD--------------LH-----------NLNLLSLYDNKLQTIAKGTFSPLRAIQ 423
Query: 201 RLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFGGNPLHCNCELLWLRRLERDD 260
+ L NP C+C L WL +
Sbjct: 424 TMHLAQ-----------------------------------NPFICDCHLKWLADYLHTN 448
Query: 261 DLET----CGSPGGLKGRYFWHVREEEFVC 286
+ET C SP L + ++ ++F C
Sbjct: 449 PIETSGARCTSPRRLANKRIGQIKSKKFRC 478
Score = 61.2 bits (147), Expect = 4e-09
Identities = 48/165 (29%), Positives = 77/165 (46%), Gaps = 30/165 (18%)
Query: 20 ACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNF---------------- 63
ACP+ C C+ + C ++ L +P I + T ELRL N
Sbjct: 505 ACPEKCRCEGTTVD----CSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQL 560
Query: 64 ---------IIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPS 114
I I F +G+ ++ L+ N + ++Q F LESL++L L SNR+
Sbjct: 561 RKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITC 620
Query: 115 LGEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYN 159
+G D+ GL +++ L + +NQ+ +A AF D L +L L+L N
Sbjct: 621 VGNDSFIGLSSVRLLSLYDNQITTVAPGAF-DTLHSLSTLNLLAN 664
Score = 59.7 bits (143), Expect = 1e-08
Identities = 45/142 (31%), Positives = 67/142 (47%), Gaps = 6/142 (4%)
Query: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVD 80
CP C C + C +KGL +P I R EL L GN + ++ +N L
Sbjct: 727 CPTECTCLDTV----VRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKE-LSNYKHLTL 781
Query: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140
+ LS N IS + SF ++ L +L L NRL + T GL +L+ L ++ N + +
Sbjct: 782 IDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVP 841
Query: 141 DEAFEDFLLTLEDLDLSYNNLH 162
+ AF D L L L + N L+
Sbjct: 842 EGAFND-LSALSHLAIGANPLY 862
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 99.8 bits (247), Expect = 9e-21
Identities = 103/358 (28%), Positives = 148/358 (41%), Gaps = 57/358 (15%)
Query: 30 LSESLGTLCPSKGLLFVPP----DIDRRTVELRLGGNFIIHISRQDFANMTGLVDLTLSR 85
LS SL TL SK + P + R T +L L N I I F + L L L R
Sbjct: 186 LSRSLLTLRLSKNRITQLPVRAFKLPRLT-QLDLNRNRIRLIEGLTFQGLNSLEVLKLQR 244
Query: 86 NTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIADEAFE 145
N IS + +F L + LHL+ N L + +L GL L L ++NN + I + +
Sbjct: 245 NNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWS 304
Query: 146 DFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLT 205
F L +L LS+NNL L +S+ + +L L L HN + HIAEG F L+ L LDL
Sbjct: 305 -FCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLD 363
Query: 206 SNRLQKLPPDPIFARSQASALT-ATPFAPPLS---------------FSFGGNPLH---- 245
N + D A S +L+ T F + + GGN +
Sbjct: 364 HNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQF 423
Query: 246 --------------------CNCELLWL-----RRLERDDDLETCGSPGGLKGRYFWHVR 280
C+C+L WL R+ + TC P LKG+ + V
Sbjct: 424 DAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVP 483
Query: 281 EEEFVCE----PPLITQHTHKLLVLEGQAATLKCKAI-GDPSPLIHWVAPDDRLVGNS 333
E FVC+ P +ITQ + + G+ C A SP+ D+ ++ N+
Sbjct: 484 PESFVCDDFLKPQIITQ-PETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNA 540
Score = 63.2 bits (152), Expect = 9e-10
Identities = 89/391 (22%), Positives = 149/391 (38%), Gaps = 70/391 (17%)
Query: 56 ELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSL 115
EL L N + + + A ++ L L LS N+ISHI +F L SLR L LD N +
Sbjct: 311 ELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGT 370
Query: 116 GEDT---------------------------LRGLVNLQHLIVNNNQLGGIADEAFEDFL 148
EDT GL L+HL + N + + +AF +
Sbjct: 371 IEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVK-M 429
Query: 149 LTLEDLDLSYNN------LHGLPWDSVRRMVNL-------HQLSLDHNLLDHIAEGTFA- 194
L++L +S ++ L LP + RM+ H SL + + +F
Sbjct: 430 KNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVC 489
Query: 195 -DLQKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFG-GNPLHCNCELLW 252
D K + + + D F S AS+ ++ P++F++ N + N ++
Sbjct: 490 DDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSS-----PMTFAWKKDNEVLTNADMEN 544
Query: 253 LRRLERDDD--------LETCGSPGGLKGRY----------FWHVREEEFVCEPPLITQH 294
+ D L G +GRY + + V P T+
Sbjct: 545 FVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKT 604
Query: 295 THKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGTLDIFITTS--- 351
H + + A L+C A G P+P I W + ++ D+F T
Sbjct: 605 PHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKI 664
Query: 352 QDSGAFTCIAANAAGEATAMVEVSIVQLPHL 382
D+G ++C A N+AG +A +++++ P L
Sbjct: 665 DDAGVYSCTAQNSAGSISANATLTVLETPSL 695
Score = 50.8 bits (120), Expect = 5e-06
Identities = 53/197 (26%), Positives = 86/197 (43%), Gaps = 37/197 (18%)
Query: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVD 80
C C C +SL C +GL +P D+ T
Sbjct: 41 CAAACTCAG--DSLD--CGGRGLAALPGDLPSWT------------------------RS 72
Query: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRL---PSLGEDTLRGLVNLQHLIVNNNQLG 137
L LS N +S I P F DL +L+ ++L++N L PSLG + ++ L + +N++
Sbjct: 73 LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAAS----SHVVSLFLQHNKIR 128
Query: 138 GIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQ 197
+ + + L+LE LDLS NN+ + + +L+L N + + G F L
Sbjct: 129 SVEGSQLKAY-LSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLS 187
Query: 198 K-LARLDLTSNRLQKLP 213
+ L L L+ NR+ +LP
Sbjct: 188 RSLLTLRLSKNRITQLP 204
Score = 47.8 bits (112), Expect = 4e-05
Identities = 27/93 (29%), Positives = 42/93 (45%)
Query: 285 VCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGTL 344
V E P + +V G+ L+CKA G+P P I W D L DN L
Sbjct: 689 VLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLL 748
Query: 345 DIFITTSQDSGAFTCIAANAAGEATAMVEVSIV 377
+ ++D+G +TC +N G A ++S++
Sbjct: 749 VVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVL 781
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 99.8 bits (247), Expect = 9e-21
Identities = 103/400 (25%), Positives = 159/400 (39%), Gaps = 63/400 (15%)
Query: 29 NLSESLGTLCPSKGLL-FVPPDIDR--RTVELRLGGNFIIHISRQDFANMTGLVDLTLSR 85
NLS SL + ++ + +PP I + L L N I + F + L L + R
Sbjct: 189 NLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQR 248
Query: 86 NTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIADEAFE 145
N IS ++ +F L ++ L L+ N L + + L GL LQ L V+ N + I+ +A+E
Sbjct: 249 NGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWE 308
Query: 146 DFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLT 205
F L +LDLSYN L L + + L +L+L N + HIA+G F L L LDL
Sbjct: 309 -FCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLR 367
Query: 206 SNRLQKLPPDP-------------IFARSQASALTATPFAPPLSFS-------------- 238
+N + D I +Q ++T F S
Sbjct: 368 NNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQE 427
Query: 239 ------------FGGNPLHCNCELLWLRRLERDDDLE-----TCGSPGGLKGRYFWHVRE 281
+ L C+C L WL + D++ + +C P L G+ +V
Sbjct: 428 NAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDL 487
Query: 282 EEFVCE---PPLITQHTHKLLVLEGQAATLKCKAI-GDPSPLIHWVAPDDRLV------- 330
++FVC+ P I H ++ L G TL C A+ SP+ D ++
Sbjct: 488 KDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTEN 547
Query: 331 ----GNSSRTAVYDNGTLDIFITTSQDSGAFTCIAANAAG 366
+ A+ L +F D G + CI N G
Sbjct: 548 FVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFG 587
Score = 60.5 bits (145), Expect = 6e-09
Identities = 49/157 (31%), Positives = 82/157 (52%), Gaps = 3/157 (1%)
Query: 57 LRLGGNFIIHISRQDFANMTG-LVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSL 115
L L N I + F N++ L+ + L+RN +S I P F L L+ L L NR+ +
Sbjct: 172 LNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIF-KLPHLQFLELKRNRIKIV 230
Query: 116 GEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNL 175
T +GL +L+ L + N + + D AF L +E+L+L +NNL + + + L
Sbjct: 231 EGLTFQGLDSLRSLKMQRNGISKLKDGAFFG-LNNMEELELEHNNLTRVNKGWLYGLRML 289
Query: 176 HQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKL 212
QL + N ++ I+ + Q+L+ LDL+ N+L +L
Sbjct: 290 QQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRL 326
Score = 51.2 bits (121), Expect = 4e-06
Identities = 28/103 (27%), Positives = 46/103 (44%)
Query: 285 VCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGTL 344
V E P + V G+ A L+C A G P+P ++W D L+ N L
Sbjct: 692 VLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLL 751
Query: 345 DIFITTSQDSGAFTCIAANAAGEATAMVEVSIVQLPHLSNSTS 387
I +D+G +TCI +N G + ++++ P+ +S S
Sbjct: 752 IIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQS 794
Score = 40.0 bits (92), Expect = 0.008
Identities = 25/99 (25%), Positives = 44/99 (44%), Gaps = 3/99 (3%)
Query: 285 VCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGTL 344
V E P + L + G A L+C A G P+P I W + ++
Sbjct: 598 VNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPED 657
Query: 345 DIFITTS---QDSGAFTCIAANAAGEATAMVEVSIVQLP 380
D+F + +D G ++C+A N AG +A +++++ P
Sbjct: 658 DVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTVLETP 696
Score = 32.0 bits (71), Expect = 2.3
Identities = 19/63 (30%), Positives = 33/63 (52%), Gaps = 1/63 (1%)
Query: 150 TLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRL 209
TL+++ ++YN L +P+ N+ LSL HN++ I L LDL+SN +
Sbjct: 98 TLQEVKMNYNELTEIPYFG-EPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNII 156
Query: 210 QKL 212
++
Sbjct: 157 SEI 159
>gi|193083136 leucine-rich repeat, immunoglobulin-like and
transmembrane domains 3 [Homo sapiens]
Length = 634
Score = 99.4 bits (246), Expect = 1e-20
Identities = 93/327 (28%), Positives = 140/327 (42%), Gaps = 32/327 (9%)
Query: 105 LHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGL 164
L ++ + + + LV LQ+L V N + I +F + L L +L L N+L
Sbjct: 17 LRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYN-LKQLHELRLDGNSLAAF 75
Query: 165 PWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQAS 224
PW S+ M L L L +N + + L+ LA LDL+SNRL LPPD F S +
Sbjct: 76 PWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLPPD--FLESW-T 132
Query: 225 ALTATP-----FAPP-LSFSFGGNPLHCNCELLWLRRLERD--------DDLETCGSPGG 270
L +TP +P + NP C+C + + L + D L TC P
Sbjct: 133 HLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLLDPLMTCSEPER 192
Query: 271 LKGRYFWHVREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLV 330
L G F E C P + K++ G L+C A G P+P I W D V
Sbjct: 193 LTGILFQRAELEH--CLKPSVMTSATKIMSALGSNVLLRCDATGFPTPQITWTRSDSSPV 250
Query: 331 GNSSRTAVYDNGT----LDIFITTSQDSGAFTCIAANAAGEATAMVEVSIVQLPHLSNST 386
+ + G + + +S+D+G + C A N AG + A+V V+++ + T
Sbjct: 251 NYTVIQESPEEGVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTVLGI------T 304
Query: 387 SRTAPPKSRLSDITGSSKTSRGGGGSG 413
+ PP + S+ TG GSG
Sbjct: 305 TTPIPPDT--SERTGDHPEWDVQPGSG 329
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 95.9 bits (237), Expect = 1e-19
Identities = 68/218 (31%), Positives = 101/218 (46%), Gaps = 25/218 (11%)
Query: 20 ACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTV------------------------ 55
ACP C CQ L C GL VP D+D T
Sbjct: 34 ACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLE 93
Query: 56 ELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSL 115
ELRL GN + HI Q F+ + L L L N + I + +L SL+SL LD+N + +
Sbjct: 94 ELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLV 153
Query: 116 GEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNL 175
E + GL +L+HL +++N L I A + L L+ + L+ N + +P + + + +L
Sbjct: 154 PERSFEGLSSLRHLWLDDNALTEIPVRALNN-LPALQAMTLALNRISHIPDYAFQNLTSL 212
Query: 176 HQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLP 213
L L +N + H+ +F L L LDL N+LQ+ P
Sbjct: 213 VVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP 250
Score = 52.0 bits (123), Expect = 2e-06
Identities = 49/180 (27%), Positives = 79/180 (43%), Gaps = 25/180 (13%)
Query: 57 LRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLG 116
+ L N I HI F N+T LV L L N I H+ SF L +L +L L+ N+L
Sbjct: 191 MTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP 250
Query: 117 EDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLH 176
+R L LQ L +NN + I ++AF L L+ + N + + + + + LH
Sbjct: 251 V-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPL-LQTIHFYDNPIQFVGRSAFQYLPKLH 308
Query: 177 QLSLDHNL-----------------------LDHIAEGTFADLQKLARLDLTSNRLQKLP 213
LSL+ + + + G L +L L+L+ N++++LP
Sbjct: 309 TLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP 368
Score = 46.6 bits (109), Expect = 9e-05
Identities = 41/164 (25%), Positives = 66/164 (40%), Gaps = 32/164 (19%)
Query: 78 LVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLG 137
L +L N I I +F+ L+++H N + +G + L L L +N G
Sbjct: 259 LQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN----G 314
Query: 138 GIADEAFEDF--------------------------LLTLEDLDLSYNNLHGLPWDSVRR 171
+ + F D L L L+LS+N + LP S+ R
Sbjct: 315 AMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHR 372
Query: 172 MVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPD 215
L ++ L HN + I TF+ L L LDL+ N ++ + P+
Sbjct: 373 CQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 416
Score = 42.7 bits (99), Expect = 0.001
Identities = 39/133 (29%), Positives = 60/133 (45%), Gaps = 4/133 (3%)
Query: 82 TLSRNTISHIQPFSFLD-LESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140
TLS N IQ F L SL L L + L + L L+ L +++NQ+ +
Sbjct: 309 TLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP 368
Query: 141 DEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLA 200
LE++ L +N + + D+ ++ +L L L N + I F+ L L
Sbjct: 369 SL---HRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLV 425
Query: 201 RLDLTSNRLQKLP 213
+LDLT N+L LP
Sbjct: 426 KLDLTDNQLTTLP 438
Score = 40.8 bits (94), Expect = 0.005
Identities = 30/79 (37%), Positives = 38/79 (48%), Gaps = 3/79 (3%)
Query: 56 ELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSL 115
E+ L N I I F+ ++ L L LS N I I P +F L SL L L N+L +L
Sbjct: 378 EIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL 437
Query: 116 GEDTLRGLVNLQHLIVNNN 134
L GL L HL + N
Sbjct: 438 ---PLAGLGGLMHLKLKGN 453
Score = 34.7 bits (78), Expect = 0.35
Identities = 23/65 (35%), Positives = 32/65 (49%)
Query: 154 LDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLP 213
LDLS NNL L + L +L L N L HI F+ L L L L +N+L +P
Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
Query: 214 PDPIF 218
+ ++
Sbjct: 131 AEALW 135
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 94.4 bits (233), Expect = 4e-19
Identities = 65/195 (33%), Positives = 101/195 (51%), Gaps = 3/195 (1%)
Query: 20 ACPKYCVCQ--NLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTG 77
ACP CVC + ++ L C S+ L +P + T L L GN + + F N++
Sbjct: 78 ACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSS 137
Query: 78 LVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLG 137
L L L + ++P + L LE+L LHL+ N+L SL T L L ++NN+L
Sbjct: 138 LGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLS 197
Query: 138 GIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQ 197
+ D FE L +L DL+L +N+L LP + R + +L +L L N L ++ F+ L
Sbjct: 198 RLEDGLFEG-LGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLA 256
Query: 198 KLARLDLTSNRLQKL 212
+L LDL+ N L+ +
Sbjct: 257 ELRELDLSRNALRAI 271
Score = 89.0 bits (219), Expect = 2e-17
Identities = 57/158 (36%), Positives = 84/158 (53%), Gaps = 1/158 (0%)
Query: 56 ELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSL 115
EL L N + I F + L L L RN I+ + P +FL L++LR L L NR+ L
Sbjct: 260 ELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGL 319
Query: 116 GEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNL 175
EDT GL+ L+ L +++N + + F+D L LE+L L +N + L S + L
Sbjct: 320 LEDTFPGLLGLRVLRLSHNAIASLRPRTFKD-LHFLEELQLGHNRIRQLAERSFEGLGQL 378
Query: 176 HQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLP 213
L+LDHN L + G F L +A ++L+ N L+ LP
Sbjct: 379 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLP 416
Score = 78.6 bits (192), Expect = 2e-14
Identities = 55/172 (31%), Positives = 82/172 (47%), Gaps = 1/172 (0%)
Query: 56 ELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSL 115
+L LG N + + F + L +L L+ N ++++QP F L LR L L N L ++
Sbjct: 212 DLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAI 271
Query: 116 GEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNL 175
+ L LQ L ++ N + +A AF L L LDLS+N + GL D+ ++ L
Sbjct: 272 KANVFVQLPRLQKLYLDRNLIAAVAPGAFLG-LKALRWLDLSHNRVAGLLEDTFPGLLGL 330
Query: 176 HQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASALT 227
L L HN + + TF DL L L L NR+++L Q LT
Sbjct: 331 RVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLT 382
Score = 76.3 bits (186), Expect = 1e-13
Identities = 62/199 (31%), Positives = 86/199 (43%), Gaps = 18/199 (9%)
Query: 57 LRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLG 116
+ L GN + ++ Q F + L L L + + I+P +F L LR L L N L +
Sbjct: 405 MNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIE 464
Query: 117 EDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLH 176
E +L GL L L + +NQL + F+ L LE L LS N L LP D++ +
Sbjct: 465 EQSLWGLAELLELDLTSNQLTHLPHRLFQG-LGKLEYLLLSRNRLAELPADALGPLQRAF 523
Query: 177 QLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLS 236
L + HN L+ + A L +L L L +N L+ P P P L
Sbjct: 524 WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----------------PGLE 567
Query: 237 -FSFGGNPLHCNCELLWLR 254
GNP C C L LR
Sbjct: 568 RLWLEGNPWDCGCPLKALR 586
Score = 37.4 bits (85), Expect = 0.055
Identities = 32/113 (28%), Positives = 48/113 (42%), Gaps = 10/113 (8%)
Query: 55 VELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPS 114
+EL L N + H+ + F + L L LSRN ++ + + L+ L + NRL +
Sbjct: 475 LELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEA 534
Query: 115 LGEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWD 167
L L L L++L + NN L T + L L G PWD
Sbjct: 535 LPNSLLAPLGRLRYLSLRNNSLR----------TFTPQPPGLERLWLEGNPWD 577
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 94.4 bits (233), Expect = 4e-19
Identities = 65/195 (33%), Positives = 101/195 (51%), Gaps = 3/195 (1%)
Query: 20 ACPKYCVCQ--NLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTG 77
ACP CVC + ++ L C S+ L +P + T L L GN + + F N++
Sbjct: 40 ACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSS 99
Query: 78 LVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLG 137
L L L + ++P + L LE+L LHL+ N+L SL T L L ++NN+L
Sbjct: 100 LGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLS 159
Query: 138 GIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQ 197
+ D FE L +L DL+L +N+L LP + R + +L +L L N L ++ F+ L
Sbjct: 160 RLEDGLFEG-LGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLA 218
Query: 198 KLARLDLTSNRLQKL 212
+L LDL+ N L+ +
Sbjct: 219 ELRELDLSRNALRAI 233
Score = 89.0 bits (219), Expect = 2e-17
Identities = 57/158 (36%), Positives = 84/158 (53%), Gaps = 1/158 (0%)
Query: 56 ELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSL 115
EL L N + I F + L L L RN I+ + P +FL L++LR L L NR+ L
Sbjct: 222 ELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGL 281
Query: 116 GEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNL 175
EDT GL+ L+ L +++N + + F+D L LE+L L +N + L S + L
Sbjct: 282 LEDTFPGLLGLRVLRLSHNAIASLRPRTFKD-LHFLEELQLGHNRIRQLAERSFEGLGQL 340
Query: 176 HQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLP 213
L+LDHN L + G F L +A ++L+ N L+ LP
Sbjct: 341 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLP 378
Score = 78.6 bits (192), Expect = 2e-14
Identities = 55/172 (31%), Positives = 82/172 (47%), Gaps = 1/172 (0%)
Query: 56 ELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSL 115
+L LG N + + F + L +L L+ N ++++QP F L LR L L N L ++
Sbjct: 174 DLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAI 233
Query: 116 GEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNL 175
+ L LQ L ++ N + +A AF L L LDLS+N + GL D+ ++ L
Sbjct: 234 KANVFVQLPRLQKLYLDRNLIAAVAPGAFLG-LKALRWLDLSHNRVAGLLEDTFPGLLGL 292
Query: 176 HQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASALT 227
L L HN + + TF DL L L L NR+++L Q LT
Sbjct: 293 RVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLT 344
Score = 76.3 bits (186), Expect = 1e-13
Identities = 62/199 (31%), Positives = 86/199 (43%), Gaps = 18/199 (9%)
Query: 57 LRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLG 116
+ L GN + ++ Q F + L L L + + I+P +F L LR L L N L +
Sbjct: 367 MNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIE 426
Query: 117 EDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLH 176
E +L GL L L + +NQL + F+ L LE L LS N L LP D++ +
Sbjct: 427 EQSLWGLAELLELDLTSNQLTHLPHRLFQG-LGKLEYLLLSRNRLAELPADALGPLQRAF 485
Query: 177 QLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLS 236
L + HN L+ + A L +L L L +N L+ P P P L
Sbjct: 486 WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----------------PGLE 529
Query: 237 -FSFGGNPLHCNCELLWLR 254
GNP C C L LR
Sbjct: 530 RLWLEGNPWDCGCPLKALR 548
Score = 37.4 bits (85), Expect = 0.055
Identities = 32/113 (28%), Positives = 48/113 (42%), Gaps = 10/113 (8%)
Query: 55 VELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPS 114
+EL L N + H+ + F + L L LSRN ++ + + L+ L + NRL +
Sbjct: 437 LELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEA 496
Query: 115 LGEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWD 167
L L L L++L + NN L T + L L G PWD
Sbjct: 497 LPNSLLAPLGRLRYLSLRNNSLR----------TFTPQPPGLERLWLEGNPWD 539
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 93.6 bits (231), Expect = 6e-19
Identities = 66/210 (31%), Positives = 103/210 (49%), Gaps = 5/210 (2%)
Query: 4 LLGGLLAFGMAFAVVDACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNF 63
LL G A+G A CP C C S+ C ++ VP + + L++
Sbjct: 15 LLVGCQAWGAGLAY-HGCPSECTCSRASQ---VECTGARIVAVPTPLPWNAMSLQILNTH 70
Query: 64 IIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGL 123
I ++ F N++ L+ L + +N +S I P +F +L SLR L L +N+L L +GL
Sbjct: 71 ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGL 130
Query: 124 VNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHN 183
+L+ L++++NQL I F L++L L N+L +P + +V L +L+L N
Sbjct: 131 DSLESLLLSSNQLLQIQPAHFSQ-CSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKN 189
Query: 184 LLDHIAEGTFADLQKLARLDLTSNRLQKLP 213
L HI+ F L L L L NRL +P
Sbjct: 190 SLTHISPRVFQHLGNLQVLRLYENRLTDIP 219
Score = 85.5 bits (210), Expect = 2e-16
Identities = 57/164 (34%), Positives = 88/164 (53%), Gaps = 2/164 (1%)
Query: 56 ELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSL 115
EL+L GN + +I F ++ GL L L +N+++HI P F L +L+ L L NRL +
Sbjct: 159 ELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI 218
Query: 116 GEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNL 175
T GLVNLQ L + NQ+G ++ F + L+ L LS N++ LP ++ L
Sbjct: 219 PMGTFDGLVNLQELALQQNQIGLLSPGLFHN-NHNLQRLYLSNNHISQLPPSIFMQLPQL 277
Query: 176 HQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFA 219
++L+L N L ++ G F + L L L N + L PD +F+
Sbjct: 278 NRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSL-PDNVFS 320
Score = 71.2 bits (173), Expect = 3e-12
Identities = 65/226 (28%), Positives = 98/226 (43%), Gaps = 21/226 (9%)
Query: 57 LRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLG 116
L L N I + F + L LTL N++ + F + +LR L L N + SL
Sbjct: 256 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 315
Query: 117 EDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLH 176
++ L LQ LI++ NQ+ I+ AF L L +L L N L L + R + NL
Sbjct: 316 DNVFSNLRQLQVLILSRNQISFISPGAFNG-LTELRELSLHTNALQDLDGNVFRMLANLQ 374
Query: 177 QLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLS 236
+SL +N L + FA++ L + L +N+L+ LP IF
Sbjct: 375 NISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLG-IFDH----------LGKLCE 423
Query: 237 FSFGGNPLHCNCELLWLR--------RLERDDDLETCGSPGGLKGR 274
NP C+ ++L LR RL D + C SP ++G+
Sbjct: 424 LRLYDNPWRCDSDILPLRNWLLLNQPRL-GTDTVPVCFSPANVRGQ 468
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/128 (35%), Positives = 61/128 (47%), Gaps = 1/128 (0%)
Query: 56 ELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSL 115
EL L N I + F+N+ L L LSRN IS I P +F L LR L L +N L L
Sbjct: 303 ELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDL 362
Query: 116 GEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNL 175
+ R L NLQ++ + NN+L + F + + L + L N L LP + L
Sbjct: 363 DGNVFRMLANLQNISLQNNRLRQLPGNIFAN-VNGLMAIQLQNNQLENLPLGIFDHLGKL 421
Query: 176 HQLSLDHN 183
+L L N
Sbjct: 422 CELRLYDN 429
Score = 37.0 bits (84), Expect = 0.071
Identities = 36/115 (31%), Positives = 54/115 (46%), Gaps = 6/115 (5%)
Query: 52 RRTVELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNR 111
R+ L L N I IS F +T L +L+L N + + F L +L+++ L +NR
Sbjct: 323 RQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNR 382
Query: 112 LPSLGEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPW 166
L L + + L + + NNQL + F D L L +L L Y+N PW
Sbjct: 383 LRQLPGNIFANVNGLMAIQLQNNQLENLPLGIF-DHLGKLCELRL-YDN----PW 431
Score = 31.6 bits (70), Expect = 3.0
Identities = 25/90 (27%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 125 NLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNL 184
N L + N + + + F + + L L + N L + + R + +L LSL +N
Sbjct: 60 NAMSLQILNTHITELNESPFLN-ISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNK 118
Query: 185 LDHIAEGTFADLQKLARLDLTSNRLQKLPP 214
L + G F L L L L+SN+L ++ P
Sbjct: 119 LQVLPIGLFQGLDSLESLLLSSNQLLQIQP 148
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 93.6 bits (231), Expect = 6e-19
Identities = 66/210 (31%), Positives = 103/210 (49%), Gaps = 5/210 (2%)
Query: 4 LLGGLLAFGMAFAVVDACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNF 63
LL G A+G A CP C C S+ C ++ VP + + L++
Sbjct: 9 LLVGCQAWGAGLAY-HGCPSECTCSRASQ---VECTGARIVAVPTPLPWNAMSLQILNTH 64
Query: 64 IIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGL 123
I ++ F N++ L+ L + +N +S I P +F +L SLR L L +N+L L +GL
Sbjct: 65 ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGL 124
Query: 124 VNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHN 183
+L+ L++++NQL I F L++L L N+L +P + +V L +L+L N
Sbjct: 125 DSLESLLLSSNQLLQIQPAHFSQ-CSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKN 183
Query: 184 LLDHIAEGTFADLQKLARLDLTSNRLQKLP 213
L HI+ F L L L L NRL +P
Sbjct: 184 SLTHISPRVFQHLGNLQVLRLYENRLTDIP 213
Score = 85.5 bits (210), Expect = 2e-16
Identities = 57/164 (34%), Positives = 88/164 (53%), Gaps = 2/164 (1%)
Query: 56 ELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSL 115
EL+L GN + +I F ++ GL L L +N+++HI P F L +L+ L L NRL +
Sbjct: 153 ELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI 212
Query: 116 GEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNL 175
T GLVNLQ L + NQ+G ++ F + L+ L LS N++ LP ++ L
Sbjct: 213 PMGTFDGLVNLQELALQQNQIGLLSPGLFHN-NHNLQRLYLSNNHISQLPPSIFMQLPQL 271
Query: 176 HQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFA 219
++L+L N L ++ G F + L L L N + L PD +F+
Sbjct: 272 NRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSL-PDNVFS 314
Score = 71.2 bits (173), Expect = 3e-12
Identities = 65/226 (28%), Positives = 98/226 (43%), Gaps = 21/226 (9%)
Query: 57 LRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLG 116
L L N I + F + L LTL N++ + F + +LR L L N + SL
Sbjct: 250 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 309
Query: 117 EDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLH 176
++ L LQ LI++ NQ+ I+ AF L L +L L N L L + R + NL
Sbjct: 310 DNVFSNLRQLQVLILSRNQISFISPGAFNG-LTELRELSLHTNALQDLDGNVFRMLANLQ 368
Query: 177 QLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLS 236
+SL +N L + FA++ L + L +N+L+ LP IF
Sbjct: 369 NISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLG-IFDH----------LGKLCE 417
Query: 237 FSFGGNPLHCNCELLWLR--------RLERDDDLETCGSPGGLKGR 274
NP C+ ++L LR RL D + C SP ++G+
Sbjct: 418 LRLYDNPWRCDSDILPLRNWLLLNQPRL-GTDTVPVCFSPANVRGQ 462
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/128 (35%), Positives = 61/128 (47%), Gaps = 1/128 (0%)
Query: 56 ELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSL 115
EL L N I + F+N+ L L LSRN IS I P +F L LR L L +N L L
Sbjct: 297 ELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDL 356
Query: 116 GEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNL 175
+ R L NLQ++ + NN+L + F + + L + L N L LP + L
Sbjct: 357 DGNVFRMLANLQNISLQNNRLRQLPGNIFAN-VNGLMAIQLQNNQLENLPLGIFDHLGKL 415
Query: 176 HQLSLDHN 183
+L L N
Sbjct: 416 CELRLYDN 423
Score = 37.0 bits (84), Expect = 0.071
Identities = 36/115 (31%), Positives = 54/115 (46%), Gaps = 6/115 (5%)
Query: 52 RRTVELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNR 111
R+ L L N I IS F +T L +L+L N + + F L +L+++ L +NR
Sbjct: 317 RQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNR 376
Query: 112 LPSLGEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPW 166
L L + + L + + NNQL + F D L L +L L Y+N PW
Sbjct: 377 LRQLPGNIFANVNGLMAIQLQNNQLENLPLGIF-DHLGKLCELRL-YDN----PW 425
Score = 31.6 bits (70), Expect = 3.0
Identities = 25/90 (27%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 125 NLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNL 184
N L + N + + + F + + L L + N L + + R + +L LSL +N
Sbjct: 54 NAMSLQILNTHITELNESPFLN-ISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNK 112
Query: 185 LDHIAEGTFADLQKLARLDLTSNRLQKLPP 214
L + G F L L L L+SN+L ++ P
Sbjct: 113 LQVLPIGLFQGLDSLESLLLSSNQLLQIQP 142
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 92.4 bits (228), Expect = 1e-18
Identities = 75/275 (27%), Positives = 117/275 (42%), Gaps = 46/275 (16%)
Query: 20 ACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLV 79
ACP C C S C GL VP I R L L N I I++ DFA
Sbjct: 33 ACPTKCTCSAASVD----CHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAG----- 83
Query: 80 DLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGI 139
L++LR LHL+ N++ + + L L+ L +N N+L +
Sbjct: 84 -------------------LKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVL 124
Query: 140 ADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKL 199
+ F+ L LDLS N + G+P + R + ++ L LD+N + I +G F L+ L
Sbjct: 125 PELLFQS-TPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDL 183
Query: 200 ARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPL-SFSFGGNPLHCNCELL----WLR 254
L L +N + ++ +T+ P + + N L+C+C L WLR
Sbjct: 184 EILTLNNNNISRI------------LVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLR 231
Query: 255 RLERDDDLETCGSPGGLKGRYFWHVREEEFVCEPP 289
+ C +P L+G V+++E+VC P
Sbjct: 232 QRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAP 266
Score = 92.0 bits (227), Expect = 2e-18
Identities = 74/271 (27%), Positives = 110/271 (40%), Gaps = 68/271 (25%)
Query: 20 ACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLV 79
+CP C C N C KGL+ +P ++ VE+RL N I I F L
Sbjct: 279 SCPSPCTCSNNIVD----CRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLK 334
Query: 80 DLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGI 139
+ +S+N IS I P +F L+SL SL L N++ + + GLV+LQ L++N N++ +
Sbjct: 335 RIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCL 394
Query: 140 ADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKL 199
F+D + NL+ LSL N L I++G FA LQ +
Sbjct: 395 RVNTFQD-------------------------LQNLNLLSLYDNKLQTISKGLFAPLQSI 429
Query: 200 ARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFGGNPLHCNCELLWLRRLERD 259
L L NP C+C L WL +D
Sbjct: 430 QTLHLAQ-----------------------------------NPFVCDCHLKWLADYLQD 454
Query: 260 DDLET----CGSPGGLKGRYFWHVREEEFVC 286
+ +ET C SP L + ++ ++F C
Sbjct: 455 NPIETSGARCSSPRRLANKRISQIKSKKFRC 485
Score = 63.5 bits (153), Expect = 7e-10
Identities = 42/142 (29%), Positives = 70/142 (49%), Gaps = 6/142 (4%)
Query: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVD 80
CP+ C C C +KGL +P + + EL L GN + + R+ + + L
Sbjct: 725 CPEQCTCMETV----VRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRE-LSALRHLTL 779
Query: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140
+ LS N+IS + ++F ++ L +L L NRL + GL +L+ L ++ N + +
Sbjct: 780 IDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVP 839
Query: 141 DEAFEDFLLTLEDLDLSYNNLH 162
+ +F D L +L L L N LH
Sbjct: 840 EGSFND-LTSLSHLALGTNPLH 860
Score = 61.6 bits (148), Expect = 3e-09
Identities = 61/273 (22%), Positives = 99/273 (36%), Gaps = 71/273 (26%)
Query: 21 CPKYCVCQNLSESLGTL--CPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGL 78
CP+ C C+ GT+ C ++ L+ +P + +LRL N + TG+
Sbjct: 505 CPEKCRCE------GTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEV------SVLEATGI 552
Query: 79 VDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGG 138
F L +LR ++L +N++ + E G ++Q L++ NQL
Sbjct: 553 -----------------FKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLET 595
Query: 139 IADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQK 198
+ F R + L L L NL+ ++ TFA L
Sbjct: 596 VHGRVF-------------------------RGLSGLKTLMLRSNLIGCVSNDTFAGLSS 630
Query: 199 LARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFGGNPLHCNCELLWLRRLER 258
+ L L NR+ + P S + NP +CNC L WL + R
Sbjct: 631 VRLLSLYDNRITTITPGAFTTLVSLSTINLL-----------SNPFNCNCHLAWLGKWLR 679
Query: 259 DDDLET----CGSPGGLKGRYFWHVREEEFVCE 287
+ + C P LK V ++F C+
Sbjct: 680 KRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCD 712
Score = 56.6 bits (135), Expect = 9e-08
Identities = 47/195 (24%), Positives = 80/195 (41%), Gaps = 41/195 (21%)
Query: 100 ESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYN 159
+ + L+L+ N L ++ + L L +L + ++NN + + + F + + L L LSYN
Sbjct: 752 KDVTELYLEGNHLTAVPRE-LSALRHLTLIDLSNNSISMLTNYTFSN-MSHLSTLILSYN 809
Query: 160 NLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFA 219
L +P + + +L L+L N + + EG+F DL L+ L L
Sbjct: 810 RLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLAL--------------- 854
Query: 220 RSQASALTATPFAPPLSFSFGGNPLHCNCELLWL----RRLERDDDLETCGSPGGLKGRY 275
G NPLHC+C L WL + ++ + C SP + R
Sbjct: 855 --------------------GTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRL 894
Query: 276 FWHVREEEFVCEPPL 290
F C+ P+
Sbjct: 895 LLTTPTHRFQCKGPV 909
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,368,504
Number of Sequences: 37866
Number of extensions: 1709858
Number of successful extensions: 18317
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 363
Number of HSP's successfully gapped in prelim test: 434
Number of HSP's that attempted gapping in prelim test: 13164
Number of HSP's gapped (non-prelim): 3829
length of query: 789
length of database: 18,247,518
effective HSP length: 110
effective length of query: 679
effective length of database: 14,082,258
effective search space: 9561853182
effective search space used: 9561853182
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.