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Search of human proteins with 54792745
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|54792745 SH2 domain containing 1B [Homo sapiens]
(132 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|54792745 SH2 domain containing 1B [Homo sapiens] 273 4e-74
gi|169234945 SH2 domain protein 1A isoform 2 [Homo sapiens] 108 2e-24
gi|4506923 SH2 domain protein 1A isoform 1 [Homo sapiens] 106 5e-24
gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sap... 89 1e-18
gi|40254823 SH2 containing inositol phosphatase isoform b [Homo ... 84 3e-17
gi|64085167 SH2 containing inositol phosphatase isoform a [Homo ... 84 3e-17
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 52 1e-07
gi|5729856 GRB2-related adaptor protein [Homo sapiens] 52 1e-07
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 52 2e-07
gi|4503787 fyn-related kinase [Homo sapiens] 52 2e-07
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 51 2e-07
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 51 2e-07
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 51 3e-07
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 51 3e-07
gi|187475373 c-src tyrosine kinase [Homo sapiens] 51 3e-07
gi|4758078 c-src tyrosine kinase [Homo sapiens] 51 3e-07
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 48 3e-06
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 48 3e-06
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 48 3e-06
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 48 3e-06
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 48 3e-06
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 47 3e-06
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 47 6e-06
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 47 6e-06
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 47 6e-06
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 46 7e-06
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 46 7e-06
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 46 7e-06
gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens] 45 1e-05
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 45 2e-05
>gi|54792745 SH2 domain containing 1B [Homo sapiens]
Length = 132
Score = 273 bits (697), Expect = 4e-74
Identities = 132/132 (100%), Positives = 132/132 (100%)
Query: 1 MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKH 60
MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKH
Sbjct: 1 MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKH 60
Query: 61 GYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRWRGLKLELETF 120
GYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRWRGLKLELETF
Sbjct: 61 GYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRWRGLKLELETF 120
Query: 121 VNSNSDYVDVLP 132
VNSNSDYVDVLP
Sbjct: 121 VNSNSDYVDVLP 132
>gi|169234945 SH2 domain protein 1A isoform 2 [Homo sapiens]
Length = 125
Score = 108 bits (269), Expect = 2e-24
Identities = 48/109 (44%), Positives = 77/109 (70%)
Query: 6 YHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYRI 65
YHG+++++ E LLL G+DG++LLRDSES+PGV CLCV + +YTYR+ + + G +
Sbjct: 7 YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSA 66
Query: 66 QTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRWRGLK 114
+TA G K+ F +K LIS F+KP+QG+V+ L P+++ S + +G++
Sbjct: 67 ETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGIR 115
>gi|4506923 SH2 domain protein 1A isoform 1 [Homo sapiens]
Length = 128
Score = 106 bits (265), Expect = 5e-24
Identities = 48/107 (44%), Positives = 75/107 (70%)
Query: 6 YHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYRI 65
YHG+++++ E LLL G+DG++LLRDSES+PGV CLCV + +YTYR+ + + G +
Sbjct: 7 YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSA 66
Query: 66 QTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRWRG 112
+TA G K+ F +K LIS F+KP+QG+V+ L P+++ S + +G
Sbjct: 67 ETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQG 113
>gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo
sapiens]
Length = 1258
Score = 88.6 bits (218), Expect = 1e-18
Identities = 42/98 (42%), Positives = 64/98 (65%)
Query: 5 YYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYR 64
+YH L++ E LL + G DG+FL+RDSES+ G LCV ++ V+TYRI + +
Sbjct: 21 WYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCVLYQKHVHTYRILPDGEDFLA 80
Query: 65 IQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIK 102
+QT++G P + F +L ELI + +PNQG+V LL P++
Sbjct: 81 VQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVE 118
>gi|40254823 SH2 containing inositol phosphatase isoform b [Homo
sapiens]
Length = 1188
Score = 84.0 bits (206), Expect = 3e-17
Identities = 40/95 (42%), Positives = 57/95 (60%)
Query: 7 HGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYRIQ 66
HG +T+ E LL + G DG+FL+R SESI LCV ++N VYTYRI + + +Q
Sbjct: 7 HGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQ 66
Query: 67 TAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPI 101
+EG + F L +LI ++K N G+V HL P+
Sbjct: 67 ASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPV 101
>gi|64085167 SH2 containing inositol phosphatase isoform a [Homo
sapiens]
Length = 1189
Score = 84.0 bits (206), Expect = 3e-17
Identities = 40/95 (42%), Positives = 57/95 (60%)
Query: 7 HGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYRIQ 66
HG +T+ E LL + G DG+FL+R SESI LCV ++N VYTYRI + + +Q
Sbjct: 7 HGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQ 66
Query: 67 TAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPI 101
+EG + F L +LI ++K N G+V HL P+
Sbjct: 67 ASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPV 101
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 52.4 bits (124), Expect = 1e-07
Identities = 38/107 (35%), Positives = 52/107 (48%), Gaps = 10/107 (9%)
Query: 2 DLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHG 61
DL +YHG LT+ E LLL G DG++LLRDS G+ L V K+ V + + E G
Sbjct: 32 DLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHV--EYTG 89
Query: 62 Y-YRIQTAEGSPKQVFPSLKELISKF-EKPNQGMVVHLLKPIKRTSP 106
Y ++ E F SLK+ + F +P G L +K P
Sbjct: 90 YSFKFGFNE------FSSLKDFVKHFANQPLIGSETGTLMVLKHPYP 130
>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
Length = 217
Score = 52.0 bits (123), Expect = 1e-07
Identities = 28/80 (35%), Positives = 47/80 (58%), Gaps = 6/80 (7%)
Query: 4 PYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYY 63
P+Y GR+++Q E +L+K G FL+R+SES PG + V++ + V +++ RE G Y
Sbjct: 59 PWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKY 118
Query: 64 RIQTAEGSPKQVFPSLKELI 83
+ ++ F SL EL+
Sbjct: 119 FLW------EEKFNSLNELV 132
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 51.6 bits (122), Expect = 2e-07
Identities = 28/80 (35%), Positives = 44/80 (55%), Gaps = 6/80 (7%)
Query: 4 PYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYY 63
P++ G++ + E +L K+ DG FL+R+SES PG L V F N V +++ R+ G Y
Sbjct: 59 PWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKY 118
Query: 64 RIQTAEGSPKQVFPSLKELI 83
+ + F SL EL+
Sbjct: 119 FLWVVK------FNSLNELV 132
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 51.6 bits (122), Expect = 2e-07
Identities = 33/98 (33%), Positives = 52/98 (53%), Gaps = 6/98 (6%)
Query: 4 PYYHGRLTKQDCET-LLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGY 62
P++ G + + D E LL E G+FL+R+SES G L V +V YRI R G
Sbjct: 115 PWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGG 174
Query: 63 YRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKP 100
+ + + +++F +L E +S + K + G+ V L KP
Sbjct: 175 FFL-----TRRRIFSTLNEFVSHYTKTSDGLCVKLGKP 207
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 51.2 bits (121), Expect = 2e-07
Identities = 34/113 (30%), Positives = 54/113 (47%), Gaps = 11/113 (9%)
Query: 4 PYYHGRLTKQDCETLLLKEG-VDGNFLLRDSESIPGVLCLCV-----SFKNIVYTYRIFR 57
P++ L+++D E LL G G+FL+R+SES G L V + +V Y+I
Sbjct: 126 PWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRN 185
Query: 58 EKHGYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRW 110
+G + I SP+ FP L EL+ + + G+ L +P + P W
Sbjct: 186 LDNGGFYI-----SPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPW 233
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 51.2 bits (121), Expect = 2e-07
Identities = 34/113 (30%), Positives = 54/113 (47%), Gaps = 11/113 (9%)
Query: 4 PYYHGRLTKQDCETLLLKEG-VDGNFLLRDSESIPGVLCLCV-----SFKNIVYTYRIFR 57
P++ L+++D E LL G G+FL+R+SES G L V + +V Y+I
Sbjct: 126 PWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRN 185
Query: 58 EKHGYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRW 110
+G + I SP+ FP L EL+ + + G+ L +P + P W
Sbjct: 186 LDNGGFYI-----SPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPW 233
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 50.8 bits (120), Expect = 3e-07
Identities = 33/105 (31%), Positives = 54/105 (51%), Gaps = 7/105 (6%)
Query: 5 YYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYR 64
+YHG +++ E LL G++G+FL+R+SES PG + + ++ VY YRI G
Sbjct: 127 WYHGPVSRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLY 185
Query: 65 IQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPI-KRTSPSL 108
+ S + F +L EL+ G++ L P KR P++
Sbjct: 186 V-----SSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTV 225
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 50.8 bits (120), Expect = 3e-07
Identities = 33/105 (31%), Positives = 54/105 (51%), Gaps = 7/105 (6%)
Query: 5 YYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYR 64
+YHG +++ E LL G++G+FL+R+SES PG + + ++ VY YRI G
Sbjct: 146 WYHGPVSRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLY 204
Query: 65 IQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPI-KRTSPSL 108
+ S + F +L EL+ G++ L P KR P++
Sbjct: 205 V-----SSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTV 244
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 50.8 bits (120), Expect = 3e-07
Identities = 30/98 (30%), Positives = 47/98 (47%), Gaps = 7/98 (7%)
Query: 3 LPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGY 62
+P++HG++T++ E LL G FL+R+S + PG LCVS V YRI
Sbjct: 80 MPWFHGKITREQAERLLYPPET-GLFLVRESTNYPGDYTLCVSCDGKVEHYRIM------ 132
Query: 63 YRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKP 100
Y + F +L +L+ + G+ L+KP
Sbjct: 133 YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKP 170
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 50.8 bits (120), Expect = 3e-07
Identities = 30/98 (30%), Positives = 47/98 (47%), Gaps = 7/98 (7%)
Query: 3 LPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGY 62
+P++HG++T++ E LL G FL+R+S + PG LCVS V YRI
Sbjct: 80 MPWFHGKITREQAERLLYPPET-GLFLVRESTNYPGDYTLCVSCDGKVEHYRIM------ 132
Query: 63 YRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKP 100
Y + F +L +L+ + G+ L+KP
Sbjct: 133 YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKP 170
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 47.8 bits (112), Expect = 3e-06
Identities = 33/96 (34%), Positives = 50/96 (52%), Gaps = 6/96 (6%)
Query: 5 YYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYR 64
+YHG +++ E LL ++G+FL+R+SES PG L + + ++ VY YRI G
Sbjct: 158 WYHGPVSRSAAE-YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVY 216
Query: 65 IQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKP 100
+ TAE F +L EL+ G+V L P
Sbjct: 217 V-TAESR----FSTLAELVHHHSTVADGLVTTLHYP 247
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 47.8 bits (112), Expect = 3e-06
Identities = 33/96 (34%), Positives = 50/96 (52%), Gaps = 6/96 (6%)
Query: 5 YYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYR 64
+YHG +++ E LL ++G+FL+R+SES PG L + + ++ VY YRI G
Sbjct: 173 WYHGPVSRSAAE-YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVY 231
Query: 65 IQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKP 100
+ TAE F +L EL+ G+V L P
Sbjct: 232 V-TAESR----FSTLAELVHHHSTVADGLVTTLHYP 262
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 47.8 bits (112), Expect = 3e-06
Identities = 33/96 (34%), Positives = 50/96 (52%), Gaps = 6/96 (6%)
Query: 5 YYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYR 64
+YHG +++ E LL ++G+FL+R+SES PG L + + ++ VY YRI G
Sbjct: 152 WYHGPVSRSAAE-YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVY 210
Query: 65 IQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKP 100
+ TAE F +L EL+ G+V L P
Sbjct: 211 V-TAESR----FSTLAELVHHHSTVADGLVTTLHYP 241
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 47.8 bits (112), Expect = 3e-06
Identities = 33/96 (34%), Positives = 50/96 (52%), Gaps = 6/96 (6%)
Query: 5 YYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYR 64
+YHG +++ E LL ++G+FL+R+SES PG L + + ++ VY YRI G
Sbjct: 158 WYHGPVSRSAAE-YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVY 216
Query: 65 IQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKP 100
+ TAE F +L EL+ G+V L P
Sbjct: 217 V-TAESR----FSTLAELVHHHSTVADGLVTTLHYP 247
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 47.8 bits (112), Expect = 3e-06
Identities = 33/96 (34%), Positives = 50/96 (52%), Gaps = 6/96 (6%)
Query: 5 YYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYR 64
+YHG +++ E LL ++G+FL+R+SES PG L + + ++ VY YRI G
Sbjct: 137 WYHGPVSRSAAE-YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVY 195
Query: 65 IQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKP 100
+ TAE F +L EL+ G+V L P
Sbjct: 196 V-TAESR----FSTLAELVHHHSTVADGLVTTLHYP 226
>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
[Homo sapiens]
Length = 593
Score = 47.4 bits (111), Expect = 3e-06
Identities = 37/113 (32%), Positives = 52/113 (46%), Gaps = 13/113 (11%)
Query: 5 YYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYR 64
++H +T + E LLL GVDG+FL R S+S PG L V +N T+ + YY
Sbjct: 6 WFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVR-RNGAVTHIKIQNTGDYYD 64
Query: 65 IQTAEGSPKQVFPSLKELISKFE------KPNQGMVVHLLKPIKRTSP-SLRW 110
+ E F +L EL+ + K G V+ L P+ P S RW
Sbjct: 65 LYGGE-----KFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERW 112
Score = 40.4 bits (93), Expect = 4e-04
Identities = 31/109 (28%), Positives = 55/109 (50%), Gaps = 10/109 (9%)
Query: 5 YYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYR 64
++HG L+ ++ E LL ++G G+FL+R+S+S PG L V + + K +
Sbjct: 112 WFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVM 171
Query: 65 IQTAE-----GSPKQVFPSLKELISKFEK----PNQGMVVHLLKPIKRT 104
I+ E G ++ F SL +L+ ++K G V+ L +P+ T
Sbjct: 172 IRCQELKYDVGGGER-FDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTT 219
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 46.6 bits (109), Expect = 6e-06
Identities = 29/101 (28%), Positives = 52/101 (51%), Gaps = 7/101 (6%)
Query: 3 LPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGY 62
+P++HG+++ Q+ L+ DG FL+R+S PG LCVSF V YR+ + G+
Sbjct: 79 MPWFHGKISGQEA-VQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL-HRDGH 136
Query: 63 YRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKR 103
I A F +L +++ + K + L++P ++
Sbjct: 137 LTIDEA-----VFFCNLMDMVEHYSKDKGAICTKLVRPKRK 172
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 46.6 bits (109), Expect = 6e-06
Identities = 29/101 (28%), Positives = 52/101 (51%), Gaps = 7/101 (6%)
Query: 3 LPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGY 62
+P++HG+++ Q+ L+ DG FL+R+S PG LCVSF V YR+ + G+
Sbjct: 121 MPWFHGKISGQEA-VQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL-HRDGH 178
Query: 63 YRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKR 103
I A F +L +++ + K + L++P ++
Sbjct: 179 LTIDEA-----VFFCNLMDMVEHYSKDKGAICTKLVRPKRK 214
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 46.6 bits (109), Expect = 6e-06
Identities = 29/101 (28%), Positives = 52/101 (51%), Gaps = 7/101 (6%)
Query: 3 LPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGY 62
+P++HG+++ Q+ L+ DG FL+R+S PG LCVSF V YR+ + G+
Sbjct: 120 MPWFHGKISGQEA-VQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL-HRDGH 177
Query: 63 YRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKR 103
I A F +L +++ + K + L++P ++
Sbjct: 178 LTIDEA-----VFFCNLMDMVEHYSKDKGAICTKLVRPKRK 213
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 46.2 bits (108), Expect = 7e-06
Identities = 32/102 (31%), Positives = 51/102 (50%), Gaps = 6/102 (5%)
Query: 3 LPYYHGRLTKQDCETLLLKEGV-DGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHG 61
LP++ G +T+++ E L++ G+ DG +LLR S + G L V+ + Y I RE +G
Sbjct: 13 LPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72
Query: 62 YYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKR 103
Y I G P+ +L + + G+V L KP R
Sbjct: 73 TYAI---AGGRTHASPA--DLCHYHSQESDGLVCLLKKPFNR 109
Score = 40.8 bits (94), Expect = 3e-04
Identities = 26/102 (25%), Positives = 56/102 (54%), Gaps = 7/102 (6%)
Query: 3 LPYYHGRLTKQDCETL-LLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHG 61
+P++HG++++++ E + L+ +G FL+R ++ G LC+ + V YRI ++K G
Sbjct: 166 MPWFHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKVLHYRIDKDKTG 224
Query: 62 YYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKR 103
++ EG + F +L +L+ + G++ L P ++
Sbjct: 225 --KLSIPEG---KKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 46.2 bits (108), Expect = 7e-06
Identities = 32/102 (31%), Positives = 51/102 (50%), Gaps = 6/102 (5%)
Query: 3 LPYYHGRLTKQDCETLLLKEGV-DGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHG 61
LP++ G +T+++ E L++ G+ DG +LLR S + G L V+ + Y I RE +G
Sbjct: 13 LPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72
Query: 62 YYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKR 103
Y I G P+ +L + + G+V L KP R
Sbjct: 73 TYAI---AGGRTHASPA--DLCHYHSQESDGLVCLLKKPFNR 109
Score = 40.8 bits (94), Expect = 3e-04
Identities = 26/102 (25%), Positives = 56/102 (54%), Gaps = 7/102 (6%)
Query: 3 LPYYHGRLTKQDCETL-LLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHG 61
+P++HG++++++ E + L+ +G FL+R ++ G LC+ + V YRI ++K G
Sbjct: 166 MPWFHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKVLHYRIDKDKTG 224
Query: 62 YYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKR 103
++ EG + F +L +L+ + G++ L P ++
Sbjct: 225 --KLSIPEG---KKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 46.2 bits (108), Expect = 7e-06
Identities = 32/111 (28%), Positives = 55/111 (49%), Gaps = 19/111 (17%)
Query: 10 LTKQDCETLLLKEG-VDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHG----YYR 64
++++D E LL G + G+F++RDSE+ G L V R + + G +Y+
Sbjct: 149 ISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSV---------RDYDPRQGDTVKHYK 199
Query: 65 IQTAEG-----SPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRW 110
I+T + SP+ F +L+EL+ ++K N G+ L P + P W
Sbjct: 200 IRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPW 250
>gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens]
Length = 825
Score = 45.4 bits (106), Expect = 1e-05
Identities = 35/108 (32%), Positives = 51/108 (47%), Gaps = 9/108 (8%)
Query: 5 YYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRI----FREKH 60
+YHGR+ +Q E L+ + DG+FL+RDS S PG L +KN+ ++I R
Sbjct: 154 WYHGRIPRQVSENLVQR---DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSE 210
Query: 61 GYYRIQ-TAEGSPKQVFPSLKELISKFEKP-NQGMVVHLLKPIKRTSP 106
Y R+Q E P L +P +Q + +PI RT P
Sbjct: 211 AYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVP 258
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 45.1 bits (105), Expect = 2e-05
Identities = 36/107 (33%), Positives = 57/107 (53%), Gaps = 12/107 (11%)
Query: 5 YYHGRLTKQDCETLLLK-EGVDGNFLLRDSESIPGVLCLCVS-FKNI----VYTYRIFRE 58
+Y G++T+++ E LLL E G FL+R+SE+ G CL VS F N V Y+I +
Sbjct: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 210
Query: 59 KHGYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTS 105
G + I + + F SL++L++ + K G+ H L + TS
Sbjct: 211 DSGGFYI-----TSRTQFNSLQQLVAYYSKHADGL-CHRLTTVCPTS 251
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.140 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,190,103
Number of Sequences: 37866
Number of extensions: 217452
Number of successful extensions: 643
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 79
Number of HSP's successfully gapped in prelim test: 55
Number of HSP's that attempted gapping in prelim test: 515
Number of HSP's gapped (non-prelim): 148
length of query: 132
length of database: 18,247,518
effective HSP length: 91
effective length of query: 41
effective length of database: 14,801,712
effective search space: 606870192
effective search space used: 606870192
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 56 (26.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.