Search of human proteins with 54607077

Search of human proteins with 54607077

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|54607077 ankyrin repeat domain 57 [Homo sapiens]
         (525 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|54607077 ankyrin repeat domain 57 [Homo sapiens]                  1076   0.0  
gi|95147559 ankyrin repeat domain 43 [Homo sapiens]                   182   9e-46
gi|157743267 ankyrin repeat domain 58 [Homo sapiens]                  135   1e-31
gi|71274172 ankyrin repeat domain 56 [Homo sapiens]                   122   8e-28
gi|239758051 PREDICTED: hypothetical protein [Homo sapiens]            89   1e-17
gi|30348954 mindbomb homolog 1 [Homo sapiens]                          55   1e-07
gi|140161500 ankyrin repeat and sterile alpha motif domain conta...    55   2e-07
gi|38176283 ankyrin repeat and SOCS box-containing protein 7 iso...    52   2e-06
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is...    52   2e-06
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is...    52   2e-06
gi|30089994 ankyrin repeat and SOCS box-containing protein 7 iso...    52   2e-06
gi|21264330 mindbomb homolog 2 [Homo sapiens]                          51   2e-06
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         50   7e-06
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                     50   7e-06
gi|62420875 integrin-linked kinase [Homo sapiens]                      49   1e-05
gi|62420873 integrin-linked kinase [Homo sapiens]                      49   1e-05
gi|4758606 integrin-linked kinase [Homo sapiens]                       49   1e-05
gi|76563940 synuclein alpha interacting protein [Homo sapiens]         49   1e-05
gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]       47   4e-05
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]       47   4e-05
gi|112799849 tumor protein p53 binding protein, 2 isoform 1 [Hom...    47   6e-05
gi|4885643 tumor protein p53 binding protein, 2 isoform 2 [Homo ...    47   6e-05
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is...    47   6e-05
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                    47   6e-05
gi|16975496 cortactin binding protein 2 [Homo sapiens]                 47   6e-05
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ...    46   7e-05
gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo ...    46   7e-05
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu...    46   7e-05
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    46   7e-05
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...    46   1e-04

>gi|54607077 ankyrin repeat domain 57 [Homo sapiens]
          Length = 525

 Score = 1076 bits (2783), Expect = 0.0
 Identities = 525/525 (100%), Positives = 525/525 (100%)

Query: 1   MEGPAEWGPEAALGPEAVLRFLAERGGRALHAELVQHFRGALGGEPEQRARARAHFKELV 60
           MEGPAEWGPEAALGPEAVLRFLAERGGRALHAELVQHFRGALGGEPEQRARARAHFKELV
Sbjct: 1   MEGPAEWGPEAALGPEAVLRFLAERGGRALHAELVQHFRGALGGEPEQRARARAHFKELV 60

Query: 61  NAVATVRVDPADGAKYVHLKKRFCEGPSEPSGDPPRIQVTAEPEAPDGPAGPEARDRLPD 120
           NAVATVRVDPADGAKYVHLKKRFCEGPSEPSGDPPRIQVTAEPEAPDGPAGPEARDRLPD
Sbjct: 61  NAVATVRVDPADGAKYVHLKKRFCEGPSEPSGDPPRIQVTAEPEAPDGPAGPEARDRLPD 120

Query: 121 AAAPESLPGQGRELGEGEPPAPAHWPPLSAGARRKNSRRDVQPLPRTPAPGPSEDLELPP 180
           AAAPESLPGQGRELGEGEPPAPAHWPPLSAGARRKNSRRDVQPLPRTPAPGPSEDLELPP
Sbjct: 121 AAAPESLPGQGRELGEGEPPAPAHWPPLSAGARRKNSRRDVQPLPRTPAPGPSEDLELPP 180

Query: 181 HGCEEADRGSSLVGATAQRPARQNLRDLVMGSSPQLKRSVCPGGSSPGSSSGGGRGRGGG 240
           HGCEEADRGSSLVGATAQRPARQNLRDLVMGSSPQLKRSVCPGGSSPGSSSGGGRGRGGG
Sbjct: 181 HGCEEADRGSSLVGATAQRPARQNLRDLVMGSSPQLKRSVCPGGSSPGSSSGGGRGRGGG 240

Query: 241 DSDSASVASSSAEEESSGGGSVTLDPLEHAWMLSASDGKWDSLEGLLTCEPGLLVKRDFI 300
           DSDSASVASSSAEEESSGGGSVTLDPLEHAWMLSASDGKWDSLEGLLTCEPGLLVKRDFI
Sbjct: 241 DSDSASVASSSAEEESSGGGSVTLDPLEHAWMLSASDGKWDSLEGLLTCEPGLLVKRDFI 300

Query: 301 TGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLL 360
           TGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLL
Sbjct: 301 TGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLL 360

Query: 361 VGAYDADVDIRDYSGKKASQYLSRSIAEEIKNLVGALDEGDGESAAGSGGGRWRLSKVLP 420
           VGAYDADVDIRDYSGKKASQYLSRSIAEEIKNLVGALDEGDGESAAGSGGGRWRLSKVLP
Sbjct: 361 VGAYDADVDIRDYSGKKASQYLSRSIAEEIKNLVGALDEGDGESAAGSGGGRWRLSKVLP 420

Query: 421 SHLITYKLSHALEDGGDHHHHHHSAEGWVGGKAKDPGRKASGSSSGRIKPRLNKIRFRTQ 480
           SHLITYKLSHALEDGGDHHHHHHSAEGWVGGKAKDPGRKASGSSSGRIKPRLNKIRFRTQ
Sbjct: 421 SHLITYKLSHALEDGGDHHHHHHSAEGWVGGKAKDPGRKASGSSSGRIKPRLNKIRFRTQ 480

Query: 481 IVHTTPSFRDPEQPLEGRGEEGVGEERPVKGHSPFTLRPKSNVFG 525
           IVHTTPSFRDPEQPLEGRGEEGVGEERPVKGHSPFTLRPKSNVFG
Sbjct: 481 IVHTTPSFRDPEQPLEGRGEEGVGEERPVKGHSPFTLRPKSNVFG 525


>gi|95147559 ankyrin repeat domain 43 [Homo sapiens]
          Length = 549

 Score =  182 bits (461), Expect = 9e-46
 Identities = 151/475 (31%), Positives = 204/475 (42%), Gaps = 69/475 (14%)

Query: 11  AALGPEAVLRFLAERGGRALHAELVQHFRGAL-GGEPEQRARARAHFKELVNAVATVRVD 69
           A +   AVL FL E GG+  ++EL+  F+  L  G+P  RA  R  FK+ VN VA V+  
Sbjct: 12  AGVSQAAVLGFLQEHGGKVRNSELLSRFKPLLDAGDPRGRAARRDRFKQFVNNVAVVK-- 69

Query: 70  PADGAKYVHLKKR---------------FCEGPSEPS-----------GDPPRIQVTAEP 103
             DG K+V L+K+                   PS+P+           G PP ++V    
Sbjct: 70  ELDGVKFVVLRKKPRPPEPEPAPFGPPGAAAQPSKPTSTVLPRSASAPGAPPLVRVPRPV 129

Query: 104 EAPDGPAGPEARDRLPDAAAPESLPGQGRELGEGEPPAPAHWPPLSAGARRKNSRRDVQP 163
           E P     P      P    P S P Q       +PP PA    L      +    D  P
Sbjct: 130 EPPGDLGLPTEPQDTP--GGPASEPAQPPGERSADPPLPA----LELAQATERPSADAAP 183

Query: 164 LPRTPAPGPSEDLELPPHGCEEADRGSSLVGATAQR------------PARQNLRDLVMG 211
            PR P+   S   + P     +A+ G        Q+            PA   LR    G
Sbjct: 184 PPRAPSEAASPCSDPP-----DAEPGPGAAKGPPQQKPCMLPVRCVPAPATLRLRAEEPG 238

Query: 212 SSPQLKRSVCPGGSS------PGSSSGGGRGRGGGDSD--------SASVASSSAEEESS 257
              QL     P  S           SG G G G G S            + S  AEE  +
Sbjct: 239 LRRQLSEEPSPRSSPLLLRRLSVEESGLGLGLGPGRSPHLRRLSRAGPRLLSPDAEELPA 298

Query: 258 GG--GSVTLDPLEHAWMLSASDGKWD-SLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGR 314
                +V L+P EH W++  + G+W   L GLL  + GL  KRDF++GFT LHWAAK G 
Sbjct: 299 APPPSAVPLEPSEHEWLVRTAGGRWTHQLHGLLLRDRGLAAKRDFMSGFTALHWAAKSGD 358

Query: 315 QELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYS 374
            E+   LV  A +   PV+++AR+ GGYT LHLAA+HGH +   LLV    A V +RD+S
Sbjct: 359 GEMALQLVEVARRSGAPVDVNARSHGGYTPLHLAALHGHEDAAVLLVVRLGAQVHVRDHS 418

Query: 375 GKKASQYLSRSIAEEIKNLVGALDEGDGESAAGSGGGRWRLSKVLPSHLITYKLS 429
           G++A QYL    +  ++ L+G            +GGG   L+   P  +    LS
Sbjct: 419 GRRAYQYLRPGSSYALRRLLGDPGLRGTTEPDATGGGSGSLAARRPVQVAATILS 473


>gi|157743267 ankyrin repeat domain 58 [Homo sapiens]
          Length = 315

 Score =  135 bits (339), Expect = 1e-31
 Identities = 86/216 (39%), Positives = 124/216 (57%), Gaps = 21/216 (9%)

Query: 224 GSSPGSSSGGGRGRGGGDS----DSASVASSSAEEES------SGGGS--VTLDPLEHAW 271
           G+   S++G GR RG          A+ A   +EE +      SG GS  + L+P EHAW
Sbjct: 58  GTLMHSAAGSGRRRGALRELLGLQRAAPAGWLSEERAEELGGPSGPGSSRLCLEPREHAW 117

Query: 272 MLSASDGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLP 331
           +L+A++G+++ L  LL  EP LL++ D ITG++ LHW AKHGR E L ++ +FA +  L 
Sbjct: 118 ILAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLR 177

Query: 332 VNIDARTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSGKKASQYLSRSIAEEIK 391
           +++ A  SGG T LHLAA+ GH  V+K+LVGA  AD   RD+SG +A  YL       ++
Sbjct: 178 LDVSAPGSGGLTPLHLAALQGHDMVIKVLVGALGADATRRDHSGHRACHYLRPDAPWRLR 237

Query: 392 NLVGALDEGDGESAAG--------SGGGRWRLSKVL 419
            L GA +E + ES +G        SG   WR +  +
Sbjct: 238 ELSGA-EEWEMESGSGCTNLNNNSSGTTAWRAASAV 272


>gi|71274172 ankyrin repeat domain 56 [Homo sapiens]
          Length = 793

 Score =  122 bits (306), Expect = 8e-28
 Identities = 66/157 (42%), Positives = 96/157 (61%), Gaps = 3/157 (1%)

Query: 240 GDSDSASVASSSAEEESSGGGSVTLDPLEHAWMLSASDGKWDSLEGLLTCEPGLLVKRDF 299
           G+  +A     ++E +SS    V LD  EH W++  + G W  +  L   +P L + +DF
Sbjct: 572 GEGSAALAPHRTSEHKSS---LVPLDAREHEWIVKLASGSWIQVWTLFWEDPQLALHKDF 628

Query: 300 ITGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKL 359
           +TG+T LHW AKHG    L  LV+ A K  + ++++ R+S GYT LHLAA+HGH  V+KL
Sbjct: 629 LTGYTALHWIAKHGDLRALQDLVSGAKKAGIVLDVNVRSSCGYTPLHLAAIHGHQGVIKL 688

Query: 360 LVGAYDADVDIRDYSGKKASQYLSRSIAEEIKNLVGA 396
           LV    + V++RD SGKK  QYL+ + + EI  L+GA
Sbjct: 689 LVQRLASRVNVRDSSGKKPWQYLTSNTSGEIWQLLGA 725



 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 62/177 (35%), Positives = 76/177 (42%), Gaps = 41/177 (23%)

Query: 13  LGPEAVLRFLAERGGRALHAELVQHFRGAL---GGEPEQRARARAHFKELVNAVATVRVD 69
           L  EA+L FL + GGR  +A L+ HF+  L      P Q    R  FK  VN+VA VR D
Sbjct: 5   LSQEALLDFLCQAGGRVTNAALLSHFKSFLRDPDASPSQHQHRRELFKGFVNSVAAVRQD 64

Query: 70  PADGAKYVHLKKRF--------CEGPSEP-------------------SGDPPRIQV--- 99
           P DG KYV LK+R+         + P EP                    G+PP+ Q    
Sbjct: 65  P-DGTKYVVLKRRYRDLLGEEGLQRPREPPAAAPSAGGAAPCSPRGARRGEPPQQQPRRR 123

Query: 100 TAEPEAPDGPAGPEARDRLPDAAAPESLPGQGRE----LGEGEPPAPAHWPPLSAGA 152
             E E  + PAG  A  R  DAA    LPG         G G   +P   PP+ A A
Sbjct: 124 RREKEPEEEPAGAAA--RAADAAC-NGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAA 177


>gi|239758051 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 243

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 84/224 (37%), Positives = 104/224 (46%), Gaps = 24/224 (10%)

Query: 133 ELGEGEPPAPAHWPPLSAGARRKNSRRDVQPLPRTPAPGPSEDLELPPHGCEEADRGSSL 192
           ELG+GEP +P    P   G RRK+S     P P    P  S+DLE PPHGC+EADRG S 
Sbjct: 24  ELGKGEP-SPCTGRPEQRG-RRKSSLAPPAPTPDA-GPQTSKDLEPPPHGCQEADRGGSW 80

Query: 193 VGATAQRPARQNLRDLVMGSSPQLKRSVCPGGSSPGSSSGGGRGRGGGDSDSASVASSSA 252
            GAT  RP RQNL DL   S   LKR++CPGGSS G+       R    + +A    S  
Sbjct: 81  -GATTSRPFRQNLSDLGRHSVLPLKRNLCPGGSSLGAPPLRTPQRRV--TLAAQRWLSRP 137

Query: 253 EEESSGGGSVTLDPLEHAWMLSASDGKW--DSLEGLLTCEPGLLVKRDFITGFTCLHWAA 310
           +  + G G      L+    L+A   +W  DSL G                G + LH   
Sbjct: 138 QRRAVGLGE-----LDQGAQLAALGLRWGVDSLGGCPRASQP--------AGHSGLHHTL 184

Query: 311 KHGRQELLAMLVNFANKHQLPVNIDA---RTSGGYTALHLAAMH 351
              R+ L        +  QLP    A   +    YTALHLAAM+
Sbjct: 185 TCLRRHLALQAGASGHAGQLPQRASAAWEQQGQSYTALHLAAMY 228


>gi|30348954 mindbomb homolog 1 [Homo sapiens]
          Length = 1006

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 31/77 (40%), Positives = 47/77 (61%), Gaps = 3/77 (3%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           GF  LH AA  G    + +L++   K   P  +D +   GYTALHLAA++ HVEV +LLV
Sbjct: 596 GFNALHHAALRGNPSAMRVLLS---KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLV 652

Query: 362 GAYDADVDIRDYSGKKA 378
              +A++DI++ + + A
Sbjct: 653 HQGNANLDIQNVNQQTA 669



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 35/105 (33%), Positives = 52/105 (49%), Gaps = 7/105 (6%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           G+T LH AA +   E+  +LV     HQ   N+D +     TALHLA    H ++V+LLV
Sbjct: 632 GYTALHLAALNNHVEVAELLV-----HQGNANLDIQNVNQQTALHLAVERQHTQIVRLLV 686

Query: 362 GAYDADVDIRDYSG-KKASQYLSRSIAEEIKNLVGALDEGDGESA 405
            A  A +DI+D  G     + L      +++ L    D G  ++A
Sbjct: 687 RA-GAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAA 730



 Score = 33.5 bits (75), Expect = 0.49
 Identities = 15/38 (39%), Positives = 26/38 (68%), Gaps = 1/38 (2%)

Query: 341 GYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSGKKA 378
           G+TA+  A+ +GHV+++KLL+   + DV+  D  G +A
Sbjct: 464 GHTAMQAASQNGHVDILKLLL-KQNVDVEAEDKDGDRA 500



 Score = 31.2 bits (69), Expect = 2.4
 Identities = 34/124 (27%), Positives = 57/124 (45%), Gaps = 17/124 (13%)

Query: 269 HAWMLSAS-DGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANK 327
           H  M +AS +G  D L+ LL  +  + V+ +   G   +H AA      ++ +L      
Sbjct: 465 HTAMQAASQNGHVDILKLLL--KQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVL------ 516

Query: 328 HQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV--GAY------DADVDIRDYSGKKAS 379
           H+   +++AR     T LH+A   GH++VVK L+  G +      + D  + D   KK  
Sbjct: 517 HRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRD 576

Query: 380 QYLS 383
             L+
Sbjct: 577 DILA 580


>gi|140161500 ankyrin repeat and sterile alpha motif domain
           containing 1 [Homo sapiens]
          Length = 1134

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 49/161 (30%), Positives = 71/161 (44%), Gaps = 26/161 (16%)

Query: 212 SSPQLKRSVCPGGSSPGSSSGGGRGRGGGDSDSASVASSSAEEESSGGGSVTLD-----P 266
           S  +L      GG       GGG G GGG   S+S   SS      G     +D     P
Sbjct: 24  SGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHPLSSLLSMWRGPNVNCVDSTGYTP 83

Query: 267 LEHAWMLSASDGKWDSLEGLLTCEPGLLVKRDFIT------GFTCLHWAAKHGRQELLAM 320
           L HA    A +G  D +E        +L++ D +T      G   LH AA  G  +++ +
Sbjct: 84  LHHA----ALNGHKDVVE--------VLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRL 131

Query: 321 LVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           L++    H     ++ + +   TALH AA +GH EVVK+L+
Sbjct: 132 LIHQGPSH---TRVNEQNNDNETALHCAAQYGHTEVVKVLL 169



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 48/188 (25%), Positives = 71/188 (37%), Gaps = 61/188 (32%)

Query: 223 GGSSPGSSSGGGRGRGGGDSDSASVASSSAEEESSGGG-------SVTLDPLEHAWMLSA 275
           GG   G S GGG G GGG     S +   +   S   G       S    PL HA    A
Sbjct: 33  GGGGGGGSGGGGGGSGGGGGGLGSSSHPLSSLLSMWRGPNVNCVDSTGYTPLHHA----A 88

Query: 276 SDGKWDSLEGLLTCEPGLLVKRDFIT------GFTCLHWAAKHGRQELLAMLVNFANKHQ 329
            +G  D +E        +L++ D +T      G   LH AA  G  +++ +L++    H 
Sbjct: 89  LNGHKDVVE--------VLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSH- 139

Query: 330 LPVNIDARTSGGYTALHLAAMHGH---------------------------------VEV 356
               ++ + +   TALH AA +GH                                 +EV
Sbjct: 140 --TRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEV 197

Query: 357 VKLLVGAY 364
           VK+L+ A+
Sbjct: 198 VKMLLNAH 205



 Score = 35.8 bits (81), Expect = 0.099
 Identities = 25/60 (41%), Positives = 36/60 (60%), Gaps = 6/60 (10%)

Query: 304 TCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLVGA 363
           T L  AA +GR E++ ML+N A+ + L  N        +T LHLAA +GH  VV++L+ A
Sbjct: 184 TPLDLAALYGRLEVVKMLLN-AHPNLLSCNTKK-----HTPLHLAARNGHKAVVQVLLDA 237



 Score = 34.7 bits (78), Expect = 0.22
 Identities = 18/43 (41%), Positives = 28/43 (65%), Gaps = 1/43 (2%)

Query: 333 NIDARTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSG 375
           N++   S GYT LH AA++GH +VV++L+   DA  ++ D  G
Sbjct: 72  NVNCVDSTGYTPLHHAALNGHKDVVEVLL-RNDALTNVADSKG 113


>gi|38176283 ankyrin repeat and SOCS box-containing protein 7
           isoform 2 [Homo sapiens]
          Length = 318

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 27/73 (36%), Positives = 46/73 (63%), Gaps = 4/73 (5%)

Query: 297 RDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEV 356
           +D I GFT LH+AA HGR  +  +++    +  +   I+A+++ G+T LH+AA +G    
Sbjct: 76  KDLIGGFTALHYAAMHGRARIARLMLESEYRSDI---INAKSNDGWTPLHVAAHYGRDSF 132

Query: 357 VKLLVGAYDADVD 369
           V+LL+  + A+VD
Sbjct: 133 VRLLL-EFKAEVD 144



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 21/68 (30%), Positives = 37/68 (54%), Gaps = 6/68 (8%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           G+T LH++A  G++  + + +       +   I     GG+TALH AAMHG   + +L++
Sbjct: 47  GWTLLHFSAARGKERCVRVFLEHGADPTVKDLI-----GGFTALHYAAMHGRARIARLML 101

Query: 362 -GAYDADV 368
              Y +D+
Sbjct: 102 ESEYRSDI 109


>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
           isoform b [Homo sapiens]
          Length = 1176

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 28/71 (39%), Positives = 46/71 (64%), Gaps = 6/71 (8%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           G TCLH AAK G  E++++L++        V+++A+ SGG+T +  AA H H+EV+++L+
Sbjct: 717 GSTCLHHAAKIGNLEMVSLLLSTGQ-----VDVNAQDSGGWTPIIWAAEHKHIEVIRMLL 771

Query: 362 GAYDADVDIRD 372
               ADV + D
Sbjct: 772 -TRGADVTLTD 781



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 57/243 (23%), Positives = 89/243 (36%), Gaps = 39/243 (16%)

Query: 161 VQPLPRTPAPGPSEDLELPPHGCEEADRGSSLVG-ATAQRPARQNLRDLVMGSSPQLKRS 219
           V P   T AP P    +  P   + +   + + G    +RP    L D +  S P L   
Sbjct: 520 VTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSL--- 576

Query: 220 VCPGGSSPGSSSGGGRGRGGGDSDSASVASSSAEEESSGGGSVTLDPLEHAWMLSASDGK 279
             P G   G  S  G   G G     ++  +   +ES     +   P +    LS   G+
Sbjct: 577 TLPNG---GCLSAVGLPLGPGRE---ALEKALVIQESERRKKLRFHPRQ--LYLSVKQGE 628

Query: 280 WDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAML------VNFANKHQLPVN 333
              +  +L        + D  +  T LH AA+ G  E+  +L      +N  +K Q    
Sbjct: 629 LQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPL 688

Query: 334 IDA---------------------RTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRD 372
           ++A                     +   G T LH AA  G++E+V LL+     DV+ +D
Sbjct: 689 MEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQD 748

Query: 373 YSG 375
             G
Sbjct: 749 SGG 751



 Score = 29.6 bits (65), Expect = 7.1
 Identities = 22/74 (29%), Positives = 36/74 (48%), Gaps = 7/74 (9%)

Query: 305 CLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLVGAY 364
           CLHWA+  G   +  +L+N         ++ A    G T LH+AA   + + V LL  + 
Sbjct: 787 CLHWASFTGSAAIAEVLLN------ARCDLHAVNYHGDTPLHIAARESYHDCV-LLFLSR 839

Query: 365 DADVDIRDYSGKKA 378
            A+ ++R+  G  A
Sbjct: 840 GANPELRNKEGDTA 853


>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
           isoform a [Homo sapiens]
          Length = 1210

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 28/71 (39%), Positives = 46/71 (64%), Gaps = 6/71 (8%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           G TCLH AAK G  E++++L++        V+++A+ SGG+T +  AA H H+EV+++L+
Sbjct: 751 GSTCLHHAAKIGNLEMVSLLLSTGQ-----VDVNAQDSGGWTPIIWAAEHKHIEVIRMLL 805

Query: 362 GAYDADVDIRD 372
               ADV + D
Sbjct: 806 -TRGADVTLTD 815



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 57/243 (23%), Positives = 89/243 (36%), Gaps = 39/243 (16%)

Query: 161 VQPLPRTPAPGPSEDLELPPHGCEEADRGSSLVG-ATAQRPARQNLRDLVMGSSPQLKRS 219
           V P   T AP P    +  P   + +   + + G    +RP    L D +  S P L   
Sbjct: 554 VTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSL--- 610

Query: 220 VCPGGSSPGSSSGGGRGRGGGDSDSASVASSSAEEESSGGGSVTLDPLEHAWMLSASDGK 279
             P G   G  S  G   G G     ++  +   +ES     +   P +    LS   G+
Sbjct: 611 TLPNG---GCLSAVGLPLGPGRE---ALEKALVIQESERRKKLRFHPRQ--LYLSVKQGE 662

Query: 280 WDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAML------VNFANKHQLPVN 333
              +  +L        + D  +  T LH AA+ G  E+  +L      +N  +K Q    
Sbjct: 663 LQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPL 722

Query: 334 IDA---------------------RTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRD 372
           ++A                     +   G T LH AA  G++E+V LL+     DV+ +D
Sbjct: 723 MEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQD 782

Query: 373 YSG 375
             G
Sbjct: 783 SGG 785



 Score = 29.6 bits (65), Expect = 7.1
 Identities = 22/74 (29%), Positives = 36/74 (48%), Gaps = 7/74 (9%)

Query: 305 CLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLVGAY 364
           CLHWA+  G   +  +L+N         ++ A    G T LH+AA   + + V LL  + 
Sbjct: 821 CLHWASFTGSAAIAEVLLN------ARCDLHAVNYHGDTPLHIAARESYHDCV-LLFLSR 873

Query: 365 DADVDIRDYSGKKA 378
            A+ ++R+  G  A
Sbjct: 874 GANPELRNKEGDTA 887


>gi|30089994 ankyrin repeat and SOCS box-containing protein 7
           isoform 1 [Homo sapiens]
          Length = 274

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 27/73 (36%), Positives = 46/73 (63%), Gaps = 4/73 (5%)

Query: 297 RDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEV 356
           +D I GFT LH+AA HGR  +  +++    +  +   I+A+++ G+T LH+AA +G    
Sbjct: 76  KDLIGGFTALHYAAMHGRARIARLMLESEYRSDI---INAKSNDGWTPLHVAAHYGRDSF 132

Query: 357 VKLLVGAYDADVD 369
           V+LL+  + A+VD
Sbjct: 133 VRLLL-EFKAEVD 144



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 21/68 (30%), Positives = 37/68 (54%), Gaps = 6/68 (8%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           G+T LH++A  G++  + + +       +   I     GG+TALH AAMHG   + +L++
Sbjct: 47  GWTLLHFSAARGKERCVRVFLEHGADPTVKDLI-----GGFTALHYAAMHGRARIARLML 101

Query: 362 -GAYDADV 368
              Y +D+
Sbjct: 102 ESEYRSDI 109


>gi|21264330 mindbomb homolog 2 [Homo sapiens]
          Length = 1013

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 40/107 (37%), Positives = 57/107 (53%), Gaps = 8/107 (7%)

Query: 266 PLEHAWMLSASDGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFA 325
           PL  A  +SA  G    +E +LT  P + V      GFT LH A+  G    LA+    A
Sbjct: 625 PLHSA--ISAGTGASGIVE-VLTEVPNIDVTATNSQGFTLLHHASLKGHA--LAVRKILA 679

Query: 326 NKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRD 372
              QL   +DA+   G+TALHLAA++ H EV ++L+     DV++R+
Sbjct: 680 RARQL---VDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRN 723



 Score = 35.8 bits (81), Expect = 0.099
 Identities = 25/77 (32%), Positives = 36/77 (46%), Gaps = 6/77 (7%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           GFT LH AA +  +E+  +L+          +++ R     + LHLA    HV +V LLV
Sbjct: 692 GFTALHLAALNNHREVAQILIREGR-----CDVNVRNRKLQSPLHLAVQQAHVGLVPLLV 746

Query: 362 GAYDADVDIRDYSGKKA 378
            A    V+  D  G  A
Sbjct: 747 DA-GCSVNAEDEEGDTA 762



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 28/91 (30%), Positives = 44/91 (48%), Gaps = 8/91 (8%)

Query: 270 AWMLSASDGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQ 329
           A  ++A  G+ + +  LL    G+ +  D   G T LH+AA   + E   +L++   +  
Sbjct: 526 ALQVAAYLGQVELIRLLLQARAGVDLPDD--EGNTALHYAALGNQPEATRVLLSAGCR-- 581

Query: 330 LPVNIDARTSGGYTALHLAAMHGHVEVVKLL 360
                DA  S   TALH+A   G +EVV+ L
Sbjct: 582 ----ADAINSTQSTALHVAVQRGFLEVVRAL 608



 Score = 31.2 bits (69), Expect = 2.4
 Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 6/62 (9%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           G T L  AA  G+ EL+ +L+      Q    +D     G TALH AA+    E  ++L+
Sbjct: 523 GRTALQVAAYLGQVELIRLLL------QARAGVDLPDDEGNTALHYAALGNQPEATRVLL 576

Query: 362 GA 363
            A
Sbjct: 577 SA 578



 Score = 30.4 bits (67), Expect = 4.1
 Identities = 27/108 (25%), Positives = 45/108 (41%), Gaps = 7/108 (6%)

Query: 289 CEPGLLVKRDFITGFTCLHWA--AKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALH 346
           CE G  V        T LH A  A  G   ++ +L    N     +++ A  S G+T LH
Sbjct: 609 CERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN-----IDVTATNSQGFTLLH 663

Query: 347 LAAMHGHVEVVKLLVGAYDADVDIRDYSGKKASQYLSRSIAEEIKNLV 394
            A++ GH   V+ ++      VD +   G  A    + +   E+  ++
Sbjct: 664 HASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQIL 711


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 36/109 (33%), Positives = 55/109 (50%), Gaps = 9/109 (8%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           G   LH A+K G  E+++ L+      Q   N+DA T  G TALH+A++ G  EVVK+LV
Sbjct: 74  GLNALHLASKEGHVEVVSELL------QREANVDAATKKGNTALHIASLAGQAEVVKVLV 127

Query: 362 GAYDADVDIRDYSGKKASQYLSRSIAEEIKNLVGALDEGDGESAAGSGG 410
               A+V+ +  +G       ++    E+   +  LD G  +S A   G
Sbjct: 128 -TNGANVNAQSQNGFTPLYMAAQENHLEVVKFL--LDNGASQSLATEDG 173



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 26/74 (35%), Positives = 44/74 (59%), Gaps = 7/74 (9%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           G+T LH AAK  + ++   L+ +        + +A T  G  ++HLAA  GHV++V LL+
Sbjct: 631 GYTPLHIAAKKNQMDIATTLLEYG------ADANAVTRQGIASVHLAAQEGHVDMVSLLL 684

Query: 362 GAYDADVDIRDYSG 375
           G  +A+V++ + SG
Sbjct: 685 GR-NANVNLSNKSG 697



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 39/138 (28%), Positives = 57/138 (41%), Gaps = 30/138 (21%)

Query: 300 ITGFTCLHWAAKHGRQELLAMLVNF-------ANKHQLPVNIDAR--------------- 337
           + G T LH AA+ G+ E++  LV         A   Q P++I AR               
Sbjct: 464 VRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGA 523

Query: 338 -----TSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSGKKASQYLSRSIAEEIKN 392
                T+ GYT LHL+A  GH +V   L+  + A + I    G       ++    E+ N
Sbjct: 524 SPNAATTSGYTPLHLSAREGHEDVAAFLLD-HGASLSITTKKGFTPLHVAAKYGKLEVAN 582

Query: 393 LVGALDEGDGESAAGSGG 410
           L+  L +     AAG  G
Sbjct: 583 LL--LQKSASPDAAGKSG 598



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 23/60 (38%), Positives = 33/60 (55%), Gaps = 6/60 (10%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           G+T LH    +G  ++    VNF  +H   VN  A+T  GYT LH AA  GH  ++ +L+
Sbjct: 730 GYTPLHVGCHYGNIKI----VNFLLQHSAKVN--AKTKNGYTPLHQAAQQGHTHIINVLL 783



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 33/96 (34%), Positives = 51/96 (53%), Gaps = 8/96 (8%)

Query: 300 ITGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKL 359
           + GFT LH A K  R +++ +L+    KH    +I A T  G T +H+AA  GHV +V  
Sbjct: 398 LNGFTPLHIACKKNRIKVMELLL----KHG--ASIQAVTESGLTPIHVAAFMGHVNIVSQ 451

Query: 360 LVGAYDADVDIRDYSGKKASQYLSRS-IAEEIKNLV 394
           L+  + A  +  +  G+ A    +RS  AE ++ LV
Sbjct: 452 LM-HHGASPNTTNVRGETALHMAARSGQAEVVRYLV 486



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 30/103 (29%), Positives = 53/103 (51%), Gaps = 9/103 (8%)

Query: 273 LSASDGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLPV 332
           L+A +G  D +  LL     + +     +G T LH AA+  R  +  +LVN         
Sbjct: 670 LAAQEGHVDMVSLLLGRNANVNLSNK--SGLTPLHLAAQEDRVNVAEVLVNQG------A 721

Query: 333 NIDARTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSG 375
           ++DA+T  GYT LH+   +G++++V  L+  + A V+ +  +G
Sbjct: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLL-QHSAKVNAKTKNG 763



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 22/58 (37%), Positives = 33/58 (56%), Gaps = 6/58 (10%)

Query: 304 TCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           T LH A+K G   ++ +L++   K      IDA+T  G T LH  A  GH +VV++L+
Sbjct: 270 TPLHVASKRGNANMVKLLLDRGAK------IDAKTRDGLTPLHCGARSGHEQVVEMLL 321



 Score = 37.4 bits (85), Expect = 0.034
 Identities = 27/94 (28%), Positives = 45/94 (47%), Gaps = 7/94 (7%)

Query: 301 TGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLL 360
           +GFT LH AA +G   +  +L+N A        +D       T LH+A+  G+  +VKLL
Sbjct: 234 SGFTPLHIAAHYGNINVATLLLNRA------AAVDFTARNDITPLHVASKRGNANMVKLL 287

Query: 361 VGAYDADVDIRDYSGKKASQYLSRSIAEEIKNLV 394
           +    A +D +   G       +RS  E++  ++
Sbjct: 288 LDR-GAKIDAKTRDGLTPLHCGARSGHEQVVEML 320



 Score = 34.7 bits (78), Expect = 0.22
 Identities = 26/64 (40%), Positives = 33/64 (51%), Gaps = 2/64 (3%)

Query: 332 VNIDARTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSGKKASQYLS-RSIAEEI 390
           V+I+     G  ALHLA+  GHVEVV  L+   +A+VD     G  A    S    AE +
Sbjct: 65  VDINICNQNGLNALHLASKEGHVEVVSELL-QREANVDAATKKGNTALHIASLAGQAEVV 123

Query: 391 KNLV 394
           K LV
Sbjct: 124 KVLV 127



 Score = 34.3 bits (77), Expect = 0.29
 Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 6/56 (10%)

Query: 306 LHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           LH AA+    +  A+L+   N      N D  +  G+T LH+AA +G++ V  LL+
Sbjct: 206 LHIAARKDDTKAAALLLQNDN------NADVESKSGFTPLHIAAHYGNINVATLLL 255



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 6/60 (10%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           GFT L+ AA+    E++  L++      L       T  G+T L +A   GH +VV LL+
Sbjct: 140 GFTPLYMAAQENHLEVVKFLLDNGASQSLA------TEDGFTPLAVALQQGHDQVVSLLL 193



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 22/70 (31%), Positives = 36/70 (51%), Gaps = 9/70 (12%)

Query: 301 TGFTCLHWAAKHGRQELLAMLVNF-ANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKL 359
           +G T LH AA +  Q++  +L++  A+ H       A    GYT LH+AA    +++   
Sbjct: 597 SGLTPLHVAAHYDNQKVALLLLDQGASPH-------AAAKNGYTPLHIAAKKNQMDIATT 649

Query: 360 LVGAYDADVD 369
           L+  Y AD +
Sbjct: 650 LL-EYGADAN 658



 Score = 31.6 bits (70), Expect = 1.9
 Identities = 21/60 (35%), Positives = 33/60 (55%), Gaps = 6/60 (10%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           G + LH A +      + +L+    +H +PV  D  T+   TALH+AA  GH +V K+L+
Sbjct: 334 GLSPLHMATQGDHLNCVQLLL----QHNVPV--DDVTNDYLTALHVAAHCGHYKVAKVLL 387



 Score = 30.0 bits (66), Expect = 5.4
 Identities = 17/58 (29%), Positives = 31/58 (53%), Gaps = 6/58 (10%)

Query: 304 TCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           T LH AA  G  ++  +L++         N +A+   G+T LH+A     ++V++LL+
Sbjct: 369 TALHVAAHCGHYKVAKVLLD------KKANPNAKALNGFTPLHIACKKNRIKVMELLL 420


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 34/103 (33%), Positives = 49/103 (47%), Gaps = 27/103 (26%)

Query: 286 LLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANK-------HQLPVNI---- 334
           LL  +PG+ V    + G T LH AA+ G   +  +L++  +         Q P+++    
Sbjct: 588 LLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAET 647

Query: 335 ----------------DARTSGGYTALHLAAMHGHVEVVKLLV 361
                           +A TS GYTALHLAA +GH+  VKLLV
Sbjct: 648 GHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLV 690



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 31/77 (40%), Positives = 42/77 (54%), Gaps = 8/77 (10%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           G+T LH AA++G    + +LV      +   ++ AR     TALHLAA HGH EVV+ LV
Sbjct: 670 GYTALHLAARNGHLATVKLLV------EEKADVLARGPLNQTALHLAAAHGHSEVVEELV 723

Query: 362 GAYDADVDIRDYSGKKA 378
            A    +D+ D  G  A
Sbjct: 724 SA--DVIDLFDEQGLSA 738



 Score = 36.6 bits (83), Expect = 0.058
 Identities = 20/75 (26%), Positives = 37/75 (49%), Gaps = 6/75 (8%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           G T +H A +HG++ ++ +L+         V++  +    +  LH AA  GH+ +VKLL 
Sbjct: 537 GRTPMHVACQHGQENIVRILLRRG------VDVSLQGKDAWLPLHYAAWQGHLPIVKLLA 590

Query: 362 GAYDADVDIRDYSGK 376
                 V+ +   G+
Sbjct: 591 KQPGVSVNAQTLDGR 605



 Score = 33.9 bits (76), Expect = 0.37
 Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 7/58 (12%)

Query: 304 TCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           T LH AA HG  E++  LV+          ID     G +ALHLAA   H + V+ L+
Sbjct: 705 TALHLAAAHGHSEVVEELVSADV-------IDLFDEQGLSALHLAAQGRHAQTVETLL 755



 Score = 29.6 bits (65), Expect = 7.1
 Identities = 22/75 (29%), Positives = 41/75 (54%), Gaps = 7/75 (9%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           G T LH A +   + ++ +L+  A K    ++++A+    +TALH AA +G     +LL+
Sbjct: 471 GSTPLHMAVERRVRGVVELLL--ARK----ISVNAKDEDQWTALHFAAQNGDESSTRLLL 524

Query: 362 GAYDADVDIRDYSGK 376
              +A V+  D+ G+
Sbjct: 525 -EKNASVNEVDFEGR 538


>gi|62420875 integrin-linked kinase [Homo sapiens]
          Length = 452

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 28/80 (35%), Positives = 41/80 (51%), Gaps = 7/80 (8%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           GF+ LHWA + GR  ++ ML+           I+    G  T LHLAA HGH ++V+ L+
Sbjct: 34  GFSPLHWACREGRSAVVEMLI------MRGARINVMNRGDDTPLHLAASHGHRDIVQKLL 87

Query: 362 GAYDADVDIRDYSGKKASQY 381
             Y AD++  +  G     Y
Sbjct: 88  -QYKADINAVNEHGNVPLHY 106


>gi|62420873 integrin-linked kinase [Homo sapiens]
          Length = 452

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 28/80 (35%), Positives = 41/80 (51%), Gaps = 7/80 (8%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           GF+ LHWA + GR  ++ ML+           I+    G  T LHLAA HGH ++V+ L+
Sbjct: 34  GFSPLHWACREGRSAVVEMLI------MRGARINVMNRGDDTPLHLAASHGHRDIVQKLL 87

Query: 362 GAYDADVDIRDYSGKKASQY 381
             Y AD++  +  G     Y
Sbjct: 88  -QYKADINAVNEHGNVPLHY 106


>gi|4758606 integrin-linked kinase [Homo sapiens]
          Length = 452

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 28/80 (35%), Positives = 41/80 (51%), Gaps = 7/80 (8%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           GF+ LHWA + GR  ++ ML+           I+    G  T LHLAA HGH ++V+ L+
Sbjct: 34  GFSPLHWACREGRSAVVEMLI------MRGARINVMNRGDDTPLHLAASHGHRDIVQKLL 87

Query: 362 GAYDADVDIRDYSGKKASQY 381
             Y AD++  +  G     Y
Sbjct: 88  -QYKADINAVNEHGNVPLHY 106


>gi|76563940 synuclein alpha interacting protein [Homo sapiens]
          Length = 919

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 28/107 (26%), Positives = 60/107 (56%), Gaps = 10/107 (9%)

Query: 285 GLLTCEPGLLVKRDFITGFTC-------LHWAAKHGRQELLAMLVNFANKHQLPVNIDAR 337
           G L C   ++ + + I   +C       +H+A  +G++++L  L+ F  +    +++D  
Sbjct: 396 GQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQG--ISLDEV 453

Query: 338 TSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSGKKASQYLSR 384
              G +A+H+A+ HG++  ++ LV  Y A+V +++++G+K SQ   R
Sbjct: 454 DQDGNSAVHVASQHGYLGCIQTLV-EYGANVTMQNHAGEKPSQSAER 499


>gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]
          Length = 1120

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 49/153 (32%), Positives = 70/153 (45%), Gaps = 22/153 (14%)

Query: 304 TCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLVGA 363
           T LH AAK+G +E++  L+         + I+ +T  G TALH AA++G  EVV+LL+  
Sbjct: 109 TPLHLAAKNGHREVIRQLLRAG------IEINRQTKTG-TALHEAALYGKTEVVRLLLEG 161

Query: 364 YDADVDIRDYSGKKA----SQYLSRSIAEEIKNLVGALDEGDGESAAGSGGGRWRLS--- 416
              DV+IR+   + A    +Q+ +   + EIK L   L E  G     +    W L    
Sbjct: 162 -GVDVNIRNTYNQTALDIVNQFTTSQASREIKQL---LREASGILKVRALKDFWNLHDPT 217

Query: 417 --KVLPSHLITYKLSHALEDGGDHHHHHHSAEG 447
              V    +IT    H   DG    H H S  G
Sbjct: 218 ALNVRAGDVITVLEQH--PDGRWKGHIHESQRG 248



 Score = 36.2 bits (82), Expect = 0.075
 Identities = 55/205 (26%), Positives = 72/205 (35%), Gaps = 49/205 (23%)

Query: 86   GPSEPSGDPPRIQVTAEPEAPDGPAGP-----EARDRLPDAAAPESLPGQGRELGEGEP- 139
            GP E +  P R +  +EP  P  P GP      A D   +   PE  P      GEG P 
Sbjct: 812  GPKEGATGPRR-RTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPF 870

Query: 140  -----------PAPAHWPPL--------------SAGARRKNSRRDVQPLP--------R 166
                       P PA  PP               S   +R+   R+ +PL          
Sbjct: 871  AEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVA 930

Query: 167  TPAPGPSEDLELPPHGCEEADRGSSLVGATAQRPARQNLRDLVMGSSPQLKRSV--CPGG 224
            +  PGP+  L  P  G  E+   SSL          Q +    +  SP ++  V  CPG 
Sbjct: 931  SATPGPAAPLPSPTPG--ESPPASSLPQPEPSSLPAQGV-PTPLAPSPAMQPPVPPCPG- 986

Query: 225  SSPG-SSSGGGRGRGGGDSDSASVA 248
              PG  SS   R  G  +  +A  A
Sbjct: 987  --PGLESSAASRWNGETEPPAAPAA 1009



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 20/56 (35%), Positives = 32/56 (57%), Gaps = 6/56 (10%)

Query: 306 LHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           LH+AA  GR E + +L+  +        ++A +  G   LHLAA +GH EV ++L+
Sbjct: 4   LHYAAWQGRLEPVRLLLRAS------AAVNAASLDGQIPLHLAAQYGHYEVSEMLL 53



 Score = 29.6 bits (65), Expect = 7.1
 Identities = 43/156 (27%), Positives = 58/156 (37%), Gaps = 28/156 (17%)

Query: 102 EPEAPDGPAGPEARDRLPDAAAPESLPGQGRE-----LGEGEPPAPAHWPPLSA------ 150
           +P  P     PE  +R P   +  SLPGQG         +G P +PA  PP  A      
Sbjct: 641 DPSPPQERNLPEGTERPPKLCS--SLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSY 698

Query: 151 ----GARRKNSRRDVQPLPRTPAPGPSEDLELPPHGCEEADRGSSL--VGATAQRPARQN 204
                A   +  R  +       PGP+E       G  E   GS+L       +RP R  
Sbjct: 699 LAGPPATPPDPPRPKRRSHSLSRPGPTEG---DAEGEAEGPVGSTLGSYATLTRRPGRSA 755

Query: 205 LRDLVMGSSPQLKRSVCPGGSSPGSSSGGGRGRGGG 240
           L    + +SP +  +  P   +P S S   R R  G
Sbjct: 756 L----VRTSPSV--TPTPARGTPRSQSFALRARRKG 785


>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
          Length = 1202

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 49/153 (32%), Positives = 70/153 (45%), Gaps = 22/153 (14%)

Query: 304 TCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLVGA 363
           T LH AAK+G +E++  L+         + I+ +T  G TALH AA++G  EVV+LL+  
Sbjct: 191 TPLHLAAKNGHREVIRQLLRAG------IEINRQTKTG-TALHEAALYGKTEVVRLLLEG 243

Query: 364 YDADVDIRDYSGKKA----SQYLSRSIAEEIKNLVGALDEGDGESAAGSGGGRWRLS--- 416
              DV+IR+   + A    +Q+ +   + EIK L   L E  G     +    W L    
Sbjct: 244 -GVDVNIRNTYNQTALDIVNQFTTSQASREIKQL---LREASGILKVRALKDFWNLHDPT 299

Query: 417 --KVLPSHLITYKLSHALEDGGDHHHHHHSAEG 447
              V    +IT    H   DG    H H S  G
Sbjct: 300 ALNVRAGDVITVLEQH--PDGRWKGHIHESQRG 330



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 31/91 (34%), Positives = 46/91 (50%), Gaps = 11/91 (12%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           GF+ LH AA  G  EL+A+L+      +    +D + S G   LH AA  G +E V+LL+
Sbjct: 49  GFSALHHAALGGSLELIALLL------EAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLL 102

Query: 362 GAYDADVDIRDYSGK----KASQYLSRSIAE 388
            A  A V+     G+     A+QY    ++E
Sbjct: 103 RA-SAAVNAASLDGQIPLHLAAQYGHYEVSE 132



 Score = 36.2 bits (82), Expect = 0.075
 Identities = 55/205 (26%), Positives = 72/205 (35%), Gaps = 49/205 (23%)

Query: 86   GPSEPSGDPPRIQVTAEPEAPDGPAGP-----EARDRLPDAAAPESLPGQGRELGEGEP- 139
            GP E +  P R +  +EP  P  P GP      A D   +   PE  P      GEG P 
Sbjct: 894  GPKEGATGPRR-RTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPF 952

Query: 140  -----------PAPAHWPPL--------------SAGARRKNSRRDVQPLP--------R 166
                       P PA  PP               S   +R+   R+ +PL          
Sbjct: 953  AEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVA 1012

Query: 167  TPAPGPSEDLELPPHGCEEADRGSSLVGATAQRPARQNLRDLVMGSSPQLKRSV--CPGG 224
            +  PGP+  L  P  G  E+   SSL          Q +    +  SP ++  V  CPG 
Sbjct: 1013 SATPGPAAPLPSPTPG--ESPPASSLPQPEPSSLPAQGV-PTPLAPSPAMQPPVPPCPG- 1068

Query: 225  SSPG-SSSGGGRGRGGGDSDSASVA 248
              PG  SS   R  G  +  +A  A
Sbjct: 1069 --PGLESSAASRWNGETEPPAAPAA 1091



 Score = 35.8 bits (81), Expect = 0.099
 Identities = 21/60 (35%), Positives = 33/60 (55%), Gaps = 6/60 (10%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           G   LH+AA  GR E + +L+  +        ++A +  G   LHLAA +GH EV ++L+
Sbjct: 82  GMRPLHYAAWQGRLEPVRLLLRAS------AAVNAASLDGQIPLHLAAQYGHYEVSEMLL 135



 Score = 29.6 bits (65), Expect = 7.1
 Identities = 43/156 (27%), Positives = 58/156 (37%), Gaps = 28/156 (17%)

Query: 102 EPEAPDGPAGPEARDRLPDAAAPESLPGQGRE-----LGEGEPPAPAHWPPLSA------ 150
           +P  P     PE  +R P   +  SLPGQG         +G P +PA  PP  A      
Sbjct: 723 DPSPPQERNLPEGTERPPKLCS--SLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSY 780

Query: 151 ----GARRKNSRRDVQPLPRTPAPGPSEDLELPPHGCEEADRGSSL--VGATAQRPARQN 204
                A   +  R  +       PGP+E       G  E   GS+L       +RP R  
Sbjct: 781 LAGPPATPPDPPRPKRRSHSLSRPGPTEG---DAEGEAEGPVGSTLGSYATLTRRPGRSA 837

Query: 205 LRDLVMGSSPQLKRSVCPGGSSPGSSSGGGRGRGGG 240
           L    + +SP +  +  P   +P S S   R R  G
Sbjct: 838 L----VRTSPSV--TPTPARGTPRSQSFALRARRKG 867


>gi|112799849 tumor protein p53 binding protein, 2 isoform 1 [Homo
            sapiens]
          Length = 1134

 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 54/201 (26%), Positives = 83/201 (41%), Gaps = 21/201 (10%)

Query: 170  PGPSEDLELPPHGCEEADRGSSLVGATAQ-RPARQNLRDLVMGSSPQLKRSVCPGGS--S 226
            P PS  L+  P G    D   +L     +  P   ++ D+ +   P       P G    
Sbjct: 830  PAPSPGLDYEPEGVP--DNSPNLQNNPEEPNPEAPHVLDVYLEEYPPYPPPPYPSGEPEG 887

Query: 227  PGSSSGGGR-----GRGGGDSDSASVASSSAEEESSGGGSVTLDPLEHAWMLSAS-DGKW 280
            PG  S   R     G+        +    +  E  + G  V  +PL  A +L +S +G++
Sbjct: 888  PGEDSVSMRPPEITGQVSLPPGKRTNLRKTGSERIAHGMRVKFNPL--ALLLDSSLEGEF 945

Query: 281  DSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSG 340
            D ++ ++       +  D   G T LH A   G  E++  LV F       VN++A  S 
Sbjct: 946  DLVQRIIYEVDDPSLPND--EGITALHNAVCAGHTEIVKFLVQFG------VNVNAADSD 997

Query: 341  GYTALHLAAMHGHVEVVKLLV 361
            G+T LH AA   +V+V K LV
Sbjct: 998  GWTPLHCAASCNNVQVCKFLV 1018


>gi|4885643 tumor protein p53 binding protein, 2 isoform 2 [Homo
           sapiens]
          Length = 1005

 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 54/201 (26%), Positives = 83/201 (41%), Gaps = 21/201 (10%)

Query: 170 PGPSEDLELPPHGCEEADRGSSLVGATAQ-RPARQNLRDLVMGSSPQLKRSVCPGGS--S 226
           P PS  L+  P G    D   +L     +  P   ++ D+ +   P       P G    
Sbjct: 701 PAPSPGLDYEPEGVP--DNSPNLQNNPEEPNPEAPHVLDVYLEEYPPYPPPPYPSGEPEG 758

Query: 227 PGSSSGGGR-----GRGGGDSDSASVASSSAEEESSGGGSVTLDPLEHAWMLSAS-DGKW 280
           PG  S   R     G+        +    +  E  + G  V  +PL  A +L +S +G++
Sbjct: 759 PGEDSVSMRPPEITGQVSLPPGKRTNLRKTGSERIAHGMRVKFNPL--ALLLDSSLEGEF 816

Query: 281 DSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSG 340
           D ++ ++       +  D   G T LH A   G  E++  LV F       VN++A  S 
Sbjct: 817 DLVQRIIYEVDDPSLPND--EGITALHNAVCAGHTEIVKFLVQFG------VNVNAADSD 868

Query: 341 GYTALHLAAMHGHVEVVKLLV 361
           G+T LH AA   +V+V K LV
Sbjct: 869 GWTPLHCAASCNNVQVCKFLV 889


>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
           isoform 1 [Homo sapiens]
          Length = 1298

 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 28/81 (34%), Positives = 47/81 (58%), Gaps = 6/81 (7%)

Query: 292 GLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMH 351
           G LV      G TCLH AAK G  E++  L++        ++++ +  GG+T +  A  +
Sbjct: 829 GALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQ-----MDVNCQDDGGWTPMIWATEY 883

Query: 352 GHVEVVKLLVGAYDADVDIRD 372
            HV++VKLL+ +  +D++IRD
Sbjct: 884 KHVDLVKLLL-SKGSDINIRD 903



 Score = 37.0 bits (84), Expect = 0.044
 Identities = 18/42 (42%), Positives = 25/42 (59%)

Query: 334 IDARTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSG 375
           +D + + G T LHLAA  GH EVV+ L+     DV+ +D  G
Sbjct: 832 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGG 873



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 55/215 (25%), Positives = 85/215 (39%), Gaps = 33/215 (15%)

Query: 167 TPAPGPSEDLELPPHGCEEADRGSSLVGATAQRPARQNLRDLVMGSSPQLKRSVCPGGSS 226
           TP PG  +       G     R  +  G+ A  P  ++  D + G++  +     P G +
Sbjct: 652 TPVPGQEK-------GSALEGRADTTTGSAAGPPLSED--DKLQGAASHVPEGFDPTGPA 702

Query: 227 ------PGSSSGGGRGRGGGDSDSASVASSSAEEESSGGGSVTLDPLEHAWMLSASDGKW 280
                 PG S G G+       +SA +A  S + +      +   P +     SA  G+ 
Sbjct: 703 GLGRPTPGLSQGPGKET----LESALIALDSEKPKK-----LRFHPKQ--LYFSARQGEL 751

Query: 281 DSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSG 340
             +  +L        K +     + LH AA+ G  ++  MLV      Q   NID  +  
Sbjct: 752 QKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLV------QAGANIDTCSED 805

Query: 341 GYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSG 375
             T L  AA + H+E VK L+ A  A VD +D  G
Sbjct: 806 QRTPLMEAAENNHLEAVKYLIKA-GALVDPKDAEG 839



 Score = 31.6 bits (70), Expect = 1.9
 Identities = 27/80 (33%), Positives = 41/80 (51%), Gaps = 9/80 (11%)

Query: 305 CLHWAAKHGRQELLAMLVNFANKHQL-PVNIDARTSGGYTALHLAAMHGHVEVVKLLVGA 363
           CLHWAA  G  ++  +L+  A K  L  VNI      G + LH+AA     + V L + +
Sbjct: 909 CLHWAAFSGCVDIAEILL--AAKCDLHAVNIH-----GDSPLHIAARENRYDCVVLFL-S 960

Query: 364 YDADVDIRDYSGKKASQYLS 383
            D+DV +++  G+   Q  S
Sbjct: 961 RDSDVTLKNKEGETPLQCAS 980


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 36/119 (30%), Positives = 56/119 (47%), Gaps = 9/119 (7%)

Query: 306 LHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLVGAYD 365
           LH AA HG  + L +LV      Q  +++D R S G T L LAA  GHVE V +L+    
Sbjct: 554 LHLAAYHGHHQALEVLV------QSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLIN-QG 606

Query: 366 ADVDIRDYSGKKASQY--LSRSIAEEIKNLVGALDEGDGESAAGSGGGRWRLSKVLPSH 422
           A + ++DY  K+   +   +   +E ++ L+G  +  +        G    +  VL  H
Sbjct: 607 ASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGH 665



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 38/124 (30%), Positives = 65/124 (52%), Gaps = 26/124 (20%)

Query: 266 PLEHAWMLSASDGKWDSLEGLLT--CEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVN 323
           PL +A   S +DGK   LE LL     PG+  K+    G+  +H++A +G +  L ++ +
Sbjct: 474 PLHYA-ATSDTDGK--CLEYLLRNDANPGIRDKQ----GYNAVHYSAAYGHRLCLQLIAS 526

Query: 324 FANKHQLPVNIDARTSGG-----------YTALHLAAMHGHVEVVKLLVGAYDADVDIRD 372
                + P+++   TSG             + LHLAA HGH + +++LV +   D+D+R+
Sbjct: 527 -----ETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSL-LDLDVRN 580

Query: 373 YSGK 376
            SG+
Sbjct: 581 SSGR 584



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 28/71 (39%), Positives = 40/71 (56%), Gaps = 7/71 (9%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           G T LH AA  G  E++ +L++         NI+A       A+H AA  GH+EVVKLLV
Sbjct: 140 GRTALHHAAFSGHGEMVKLLLSRG------ANINAFDKKDRRAIHWAAYMGHIEVVKLLV 193

Query: 362 GAYDADVDIRD 372
            ++ A+V  +D
Sbjct: 194 -SHGAEVTCKD 203



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 38/134 (28%), Positives = 57/134 (42%), Gaps = 32/134 (23%)

Query: 273 LSASDGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKH---- 328
           L+A  G  + ++ L+     +LVK D+I   T +H AA +G  E L +L+  A       
Sbjct: 589 LAAFKGHVECVDVLINQGASILVK-DYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVD 647

Query: 329 ------QLPV--------------------NIDARTSGGYTALHLAAMHGHVEVVKLLVG 362
                 Q P+                    N+DA+   G TALH  A+ GH E V  L+ 
Sbjct: 648 IQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALL- 706

Query: 363 AYDADVDIRDYSGK 376
            + A   +RD  G+
Sbjct: 707 QHGAKCLLRDSRGR 720



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 29/103 (28%), Positives = 47/103 (45%), Gaps = 29/103 (28%)

Query: 302 GFTCLHWAAKHGRQELLAMLVN-----------FANKHQLPVN----------------- 333
           G+T LHWA  +G +  + +L+            F+  H   +N                 
Sbjct: 756 GYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASI 815

Query: 334 IDARTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSGK 376
           ++A  S G T LH AA   HVE ++LL+ +++A V+  D +GK
Sbjct: 816 VNATDSKGRTPLHAAAFTDHVECLQLLL-SHNAQVNSVDSTGK 857



 Score = 36.6 bits (83), Expect = 0.058
 Identities = 22/67 (32%), Positives = 33/67 (49%), Gaps = 9/67 (13%)

Query: 306 LHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLVGAYD 365
           +HWAA  G  E++ +LV+          +  +    YT LH AA  G + VVK L+   D
Sbjct: 177 IHWAAYMGHIEVVKLLVSHG------AEVTCKDKKSYTPLHAAASSGMISVVKYLL---D 227

Query: 366 ADVDIRD 372
             VD+ +
Sbjct: 228 LGVDMNE 234



 Score = 33.9 bits (76), Expect = 0.37
 Identities = 34/110 (30%), Positives = 48/110 (43%), Gaps = 11/110 (10%)

Query: 272 MLSASDGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLP 331
           MLS  +G  D +  LL     +  K  +  G T LH  A  G +E +  L+    K  L 
Sbjct: 658 MLSVLNGHTDCVYSLLNKGANVDAKDKW--GRTALHRGAVTGHEECVDALLQHGAKCLL- 714

Query: 332 VNIDARTSGGYTALHLAAMHGHVEVVKLLV---GAYDADVDIRDYSGKKA 378
                R S G T +HL+A  GH+ V+  L+    + DA+    D  G  A
Sbjct: 715 -----RDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTA 759



 Score = 33.5 bits (75), Expect = 0.49
 Identities = 27/92 (29%), Positives = 46/92 (50%), Gaps = 12/92 (13%)

Query: 286 LLTCEPGLLVKRDFITGFTCLHWAAK--HGRQELLAMLVNFANKHQLPVNIDARTSGGYT 343
           L+ C  G +V +    GFT LH+AA   HG   L  ++ N A+       ++ ++  G T
Sbjct: 258 LIDC--GAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGAD-------VNMKSKDGKT 308

Query: 344 ALHLAAMHGHVEVVKLLVGAYDADVDIRDYSG 375
            LH+ A+HG     + ++ +  A +D  D +G
Sbjct: 309 PLHMTALHGRFSRSQTIIQS-GAVIDCEDKNG 339



 Score = 33.1 bits (74), Expect = 0.64
 Identities = 34/113 (30%), Positives = 50/113 (44%), Gaps = 9/113 (7%)

Query: 273 LSASDGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLPV 332
           L+A  G  D    LL+    +    DF  G TCLH AA  G  E L +L+N         
Sbjct: 378 LAALSGFSDCCRKLLSSGFDIDTPDDF--GRTCLHAAAAGGNLECLNLLLNTG------A 429

Query: 333 NIDARTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSGKKASQYLSRS 385
           + + +   G + LH AA + + + +  LVG+  A V+  D  G     Y + S
Sbjct: 430 DFNKKDKFGRSPLHYAAANCNYQCLFALVGS-GASVNDLDERGCTPLHYAATS 481



 Score = 32.7 bits (73), Expect = 0.83
 Identities = 18/46 (39%), Positives = 28/46 (60%), Gaps = 1/46 (2%)

Query: 333 NIDARTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSGKKA 378
           N++     G TALH AA  GH E+VKLL+ +  A+++  D   ++A
Sbjct: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLL-SRGANINAFDKKDRRA 176



 Score = 32.7 bits (73), Expect = 0.83
 Identities = 20/60 (33%), Positives = 27/60 (45%), Gaps = 6/60 (10%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           G T LH  A HGR      ++      Q    ID     G T LH+AA +GH  ++  L+
Sbjct: 306 GKTPLHMTALHGRFSRSQTII------QSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 25/91 (27%), Positives = 45/91 (49%), Gaps = 4/91 (4%)

Query: 272 MLSASDGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLP 331
           M++A +G+ +++E L++     L  +D     T LH A   G +    +++       L 
Sbjct: 861 MMAAENGQTNTVEMLVSSASAELTLQDNSKN-TALHLACSKGHETSALLILEKITDRNL- 918

Query: 332 VNIDARTSGGYTALHLAAMHGHVEVVKLLVG 362
             I+A  +   T LH+AA +G   VV+ L+G
Sbjct: 919 --INATNAALQTPLHVAARNGLTMVVQELLG 947



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 23/61 (37%), Positives = 33/61 (54%), Gaps = 4/61 (6%)

Query: 302 GFTCLHWAAKHGRQELL-AMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLL 360
           G T +H +A  G   +L A+L + A+    P   D   + GYTALH A  +GH   V+LL
Sbjct: 719 GRTPIHLSAACGHIGVLGALLQSAASMDANPATAD---NHGYTALHWACYNGHETCVELL 775

Query: 361 V 361
           +
Sbjct: 776 L 776


>gi|16975496 cortactin binding protein 2 [Homo sapiens]
          Length = 1663

 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 76/303 (25%), Positives = 107/303 (35%), Gaps = 55/303 (18%)

Query: 90  PSGDPPRIQVTAEPEAPDGPAGPEARDRLPDAAAPESLPGQGRELGEGEPPAPAHWPPLS 149
           PS   P+++V  +             D    A+ P SLP   R + E   P  +      
Sbjct: 556 PSPPHPQLKVIIDSSRASNTGAKV--DNKTVASTPSSLPQGNRVINEENLPKSSS----- 608

Query: 150 AGARRKNSRRDVQPLPRTPAPGPSEDLELPPHGCEEADRGSSLVGATAQRPARQNLRDLV 209
                          P+ P P PS DL + P GC  +   +S VGA     A   L    
Sbjct: 609 ---------------PQLP-PKPSIDLTVAPAGCAVSALATSQVGAWPA--ATPGLNQPA 650

Query: 210 MGSSPQLKRSVCPGGSSPGSSSGGGRGRGGGDS--DSASVASSSAEEESSGGGSVTLDPL 267
              S  +  +     SS    S      G  DS   +AS  S S       GG   L   
Sbjct: 651 CSDSSLVIPTTIAFCSSINPVSASSCRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGR 710

Query: 268 EHAWMLSASDGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAML------ 321
                 +A+ G    L  LL  E GL +      G + L+ AAK+G  + + +L      
Sbjct: 711 PTLLQQAAAQGNVTLLSMLLN-EEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ 769

Query: 322 VNFANKH---------------------QLPVNIDARTSGGYTALHLAAMHGHVEVVKLL 360
           VN A+K+                         NI+    GG T L+LA  +G+ E +KLL
Sbjct: 770 VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829

Query: 361 VGA 363
           + A
Sbjct: 830 LEA 832



 Score = 35.8 bits (81), Expect = 0.099
 Identities = 24/88 (27%), Positives = 48/88 (54%), Gaps = 8/88 (9%)

Query: 274 SASDGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLPVN 333
           +A+ G ++ +E L++ +  +    D   G T L+ A K+G +E + +L+      +   N
Sbjct: 784 AAAQGHFECVELLISYDANINHAAD--GGQTPLYLACKNGNKECIKLLL------EAGTN 835

Query: 334 IDARTSGGYTALHLAAMHGHVEVVKLLV 361
              +T+ G+T +H A   G+V+ +KLL+
Sbjct: 836 RSVKTTDGWTPVHAAVDTGNVDSLKLLM 863


>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
           sapiens]
          Length = 226

 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 34/116 (29%), Positives = 55/116 (47%), Gaps = 8/116 (6%)

Query: 275 ASDGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNI 334
           A  GK + L+  +  +  L  + D  +  T LHWA   G  E++  L+      QL V +
Sbjct: 14  AYSGKLEELKESILADKSLATRTDQDSR-TALHWACSAGHTEIVEFLL------QLGVPV 66

Query: 335 DARTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSGKKASQYLSRSIAEEI 390
           + +   G++ LH+AA  G  E+VK L+G   A V+  + +G     Y +     EI
Sbjct: 67  NDKDDAGWSPLHIAASAGRDEIVKALLGK-GAQVNAVNQNGCTPLHYAASKNRHEI 121



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 32/103 (31%), Positives = 52/103 (50%), Gaps = 9/103 (8%)

Query: 273 LSASDGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLPV 332
           ++AS G+ + ++ LL    G  V      G T LH+AA   R E+  ML+          
Sbjct: 79  IAASAGRDEIVKALLG--KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG------A 130

Query: 333 NIDARTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSG 375
           N DA+     TA+H AA  G+++++ +L+  Y A  +I+D  G
Sbjct: 131 NPDAKDHYEATAMHRAAAKGNLKMIHILL-YYKASTNIQDTEG 172


>gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo
           sapiens]
          Length = 151

 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 34/116 (29%), Positives = 55/116 (47%), Gaps = 8/116 (6%)

Query: 275 ASDGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNI 334
           A  GK + L+  +  +  L  + D  +  T LHWA   G  E++  L+      QL V +
Sbjct: 14  AYSGKLEELKESILADKSLATRTDQDSR-TALHWACSAGHTEIVEFLL------QLGVPV 66

Query: 335 DARTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSGKKASQYLSRSIAEEI 390
           + +   G++ LH+AA  G  E+VK L+G   A V+  + +G     Y +     EI
Sbjct: 67  NDKDDAGWSPLHIAASAGRDEIVKALLGK-GAQVNAVNQNGCTPLHYAASKNRHEI 121


>gi|116875852 HECT domain and ankyrin repeat containing, E3
           ubiquitin protein ligase 1 [Homo sapiens]
          Length = 909

 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 27/74 (36%), Positives = 41/74 (55%), Gaps = 7/74 (9%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           G T +HW A +GR ELL  LV   +      ++D   + G TALH+A  +GH   V+ L+
Sbjct: 131 GLTAIHWLAVNGRTELLHDLVQHVS------DVDVEDAMGQTALHVACQNGHKTTVQCLL 184

Query: 362 GAYDADVDIRDYSG 375
            +  AD++  + SG
Sbjct: 185 DS-GADINRPNVSG 197


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 45/141 (31%), Positives = 67/141 (47%), Gaps = 23/141 (16%)

Query: 233 GGRGRGGGDSDSASVASSSAEEESSGGGSVTLDPLEHAWMLSASDGKWDSLEGLLTCEPG 292
           G R  GGG    A+ AS++AE          ++P       +  +G  + ++ L+T  P 
Sbjct: 3   GRRCAGGG----AACASAAAE---------AVEPAARELFEACRNGDVERVKRLVT--PE 47

Query: 293 LLVKRDFI-TGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMH 351
            +  RD      T LH+AA  GR++++  L+      Q   N+ AR  GG   LH A   
Sbjct: 48  KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLL------QNGANVQARDDGGLIPLHNACSF 101

Query: 352 GHVEVVKLLVGAYDADVDIRD 372
           GH EVV LL+  + AD + RD
Sbjct: 102 GHAEVVNLLL-RHGADPNARD 121



 Score = 37.0 bits (84), Expect = 0.044
 Identities = 25/69 (36%), Positives = 37/69 (53%), Gaps = 7/69 (10%)

Query: 304 TCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLVGA 363
           T LH AA +   E+   L+      Q   +++A+  GG   LH AA +GHV+V  LL+  
Sbjct: 681 TPLHLAAGYNNLEVAEYLL------QHGADVNAQDKGGLIPLHNAASYGHVDVAALLI-K 733

Query: 364 YDADVDIRD 372
           Y+A V+  D
Sbjct: 734 YNACVNATD 742



 Score = 36.6 bits (83), Expect = 0.058
 Identities = 24/69 (34%), Positives = 37/69 (53%), Gaps = 7/69 (10%)

Query: 304 TCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLVGA 363
           T LH+AA + R  ++  L+      Q   ++ A+  GG   LH A  +GH EV +LLV  
Sbjct: 528 TPLHFAAGYNRVSVVEYLL------QHGADVHAKDKGGLVPLHNACSYGHYEVAELLV-K 580

Query: 364 YDADVDIRD 372
           + A V++ D
Sbjct: 581 HGAVVNVAD 589



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 26/85 (30%), Positives = 46/85 (54%), Gaps = 7/85 (8%)

Query: 304 TCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLVGA 363
           T LH A++    +++ ++V    KH+  VN  A  + G T+LH AA  GH++  +LL+ +
Sbjct: 402 TPLHVASEKAHNDVVEVVV----KHEAKVN--ALDNLGQTSLHRAAYCGHLQTCRLLL-S 454

Query: 364 YDADVDIRDYSGKKASQYLSRSIAE 388
           Y  D +I    G  A Q  + ++ +
Sbjct: 455 YGCDPNIISLQGFTALQMGNENVQQ 479



 Score = 34.7 bits (78), Expect = 0.22
 Identities = 32/105 (30%), Positives = 52/105 (49%), Gaps = 9/105 (8%)

Query: 274 SASDGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLPVN 333
           +A  G+ D +E LL     +  + D   G   LH A   G  E++ +L+    +H    N
Sbjct: 65  AAGFGRKDVVEYLLQNGANVQARDD--GGLIPLHNACSFGHAEVVNLLL----RHGADPN 118

Query: 334 IDARTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSGKKA 378
             AR +  YT LH AA+ G ++V  +L+  + A+  IR+  G+ A
Sbjct: 119 --ARDNWNYTPLHEAAIKGKIDVCIVLL-QHGAEPTIRNTDGRTA 160



 Score = 33.9 bits (76), Expect = 0.37
 Identities = 20/58 (34%), Positives = 31/58 (53%), Gaps = 6/58 (10%)

Query: 304 TCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           T LH AA + R +++ +L+      Q   ++ A+  G    LH A  +GH EV +LLV
Sbjct: 213 TPLHLAAGYNRVKIVQLLL------QHGADVHAKDKGDLVPLHNACSYGHYEVTELLV 264



 Score = 32.7 bits (73), Expect = 0.83
 Identities = 22/66 (33%), Positives = 37/66 (56%), Gaps = 10/66 (15%)

Query: 309 AAKHGRQELLAMLVNFANKHQLPVNIDARTSGGY--TALHLAAMHGHVEVVKLLVGAYDA 366
           +A+ G +E +  L+        P+N++   S G   T LHLAA +  V++V+LL+  + A
Sbjct: 184 SARSGNEEKMMALLT-------PLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLL-QHGA 235

Query: 367 DVDIRD 372
           DV  +D
Sbjct: 236 DVHAKD 241



 Score = 32.7 bits (73), Expect = 0.83
 Identities = 35/103 (33%), Positives = 47/103 (45%), Gaps = 14/103 (13%)

Query: 306 LHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLVGAYD 365
           LH A  +G  E+  +LV    KH   VN  A     +T LH AA    VEV  LL+ +Y 
Sbjct: 248 LHNACSYGHYEVTELLV----KHGACVN--AMDLWQFTPLHEAASKNRVEVCSLLL-SYG 300

Query: 366 ADVDIRDYSGKKA-----SQYLSRSIAEEIK--NLVGALDEGD 401
           AD  + +   K A     +  L   +A E K  +L+ A  E D
Sbjct: 301 ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREAD 343



 Score = 30.8 bits (68), Expect = 3.2
 Identities = 22/60 (36%), Positives = 29/60 (48%), Gaps = 6/60 (10%)

Query: 302 GFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV 361
           G   LH A  +G  E+  +LV    KH   VN+       +T LH AA  G  E+ KLL+
Sbjct: 559 GLVPLHNACSYGHYEVAELLV----KHGAVVNVADLWK--FTPLHEAAAKGKYEICKLLL 612


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 48/165 (29%), Positives = 76/165 (46%), Gaps = 23/165 (13%)

Query: 252 AEEESSGG--GSVTLDPLEHAWMLSASDGKWDSLEGLLTC--EPGLLVKRDFITGFTCLH 307
           AE  ++ G  G+V   PL     L+A  G+   +  LL C  +P    +    +G+T LH
Sbjct: 613 AESHANMGALGAVNWTPLH----LAARHGEEAVVSALLQCGADPNAAEQ----SGWTPLH 664

Query: 308 WAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLVGAYDAD 367
            A +   +     ++N    H    N+ AR   G+T  HLAA+ G+  ++K+LV A  A 
Sbjct: 665 LAVQ---RSTFLSVINLLEHH---ANVHARNKVGWTPAHLAALKGNTAILKVLVEA-GAQ 717

Query: 368 VDIRDYSGKKASQYLSRSIAEEIKNLVGALDEGDGESAAGSGGGR 412
           +D++D       Q   RS  + I + +    EG   S A  GG +
Sbjct: 718 LDVQDGVSCTPLQLALRSRKQGIMSFL----EGKEPSVATLGGSK 758



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 23/64 (35%), Positives = 36/64 (56%), Gaps = 6/64 (9%)

Query: 301 TGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLL 360
           +G+  LH AA  G+  +  ML+ +    +LP      T  G+T LHLAA  GH+E++ LL
Sbjct: 559 SGYGPLHTAAARGKYLICKMLLRYGASLELP------THQGWTPLHLAAYKGHLEIIHLL 612

Query: 361 VGAY 364
             ++
Sbjct: 613 AESH 616



 Score = 37.4 bits (85), Expect = 0.034
 Identities = 48/170 (28%), Positives = 75/170 (44%), Gaps = 41/170 (24%)

Query: 287 LTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALH 346
           L  + G  V      G+T LH AA++  + +  +LV+     Q   N+    + G T LH
Sbjct: 446 LLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS----RQADPNL--HEAEGKTPLH 499

Query: 347 LAAMHGHVEVVKLLVGAYDADVDIRDYS-----------GK-KASQYLSRSIAEEIKNLV 394
           +AA  GHV +VKLL  +  A++D +  +           GK +A Q+L +S A     + 
Sbjct: 500 VAAYFGHVSLVKLLT-SQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGA-----VP 553

Query: 395 GALDE-GDGESAAGSGGGRWRLSKVL----------------PSHLITYK 427
            ALD+ G G     +  G++ + K+L                P HL  YK
Sbjct: 554 DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.133    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,709,242
Number of Sequences: 37866
Number of extensions: 1533877
Number of successful extensions: 14894
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 341
Number of HSP's successfully gapped in prelim test: 834
Number of HSP's that attempted gapping in prelim test: 9209
Number of HSP's gapped (non-prelim): 5006
length of query: 525
length of database: 18,247,518
effective HSP length: 107
effective length of query: 418
effective length of database: 14,195,856
effective search space: 5933867808
effective search space used: 5933867808
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.