BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|54607014 TBC1 domain family, member 25 [Homo sapiens] (688 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|54607014 TBC1 domain family, member 25 [Homo sapiens] 1397 0.0 gi|13375952 TBC1 domain family, member 17 [Homo sapiens] 187 3e-47 gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens] 179 6e-45 gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens] 179 6e-45 gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens] 179 6e-45 gi|33563376 TBC1 domain family, member 16 [Homo sapiens] 153 6e-37 gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo sa... 110 3e-24 gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo sa... 110 3e-24 gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sa... 107 3e-23 gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sa... 107 3e-23 gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sap... 107 3e-23 gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sap... 107 3e-23 gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 60 5e-09 gi|190014603 TBC1 domain family, member 13 [Homo sapiens] 60 9e-09 gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 56 1e-07 gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 56 1e-07 gi|23503283 TBC1 domain family, member 21 [Homo sapiens] 56 1e-07 gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 53 8e-07 gi|40068063 TBC1 domain family, member 22B [Homo sapiens] 51 3e-06 gi|148806902 TBC1 domain family, member 12 [Homo sapiens] 51 3e-06 gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 51 4e-06 gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens] 50 5e-06 gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens] 50 5e-06 gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens] 50 5e-06 gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 50 9e-06 gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap... 48 3e-05 gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 48 3e-05 gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 47 5e-05 gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 47 5e-05 gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 47 6e-05 >gi|54607014 TBC1 domain family, member 25 [Homo sapiens] Length = 688 Score = 1397 bits (3615), Expect = 0.0 Identities = 688/688 (100%), Positives = 688/688 (100%) Query: 1 MATASGASDLSGSGAPPPGVGAQAAAAAEEEEREVVRVRVKKCESFLPPEFRSFAVDPQI 60 MATASGASDLSGSGAPPPGVGAQAAAAAEEEEREVVRVRVKKCESFLPPEFRSFAVDPQI Sbjct: 1 MATASGASDLSGSGAPPPGVGAQAAAAAEEEEREVVRVRVKKCESFLPPEFRSFAVDPQI 60 Query: 61 TSLDVLQHILIRAFDLSGKKNFGISYLGRDRLGQEVYLSLLSDWDLSTAFATASKPYLQL 120 TSLDVLQHILIRAFDLSGKKNFGISYLGRDRLGQEVYLSLLSDWDLSTAFATASKPYLQL Sbjct: 61 TSLDVLQHILIRAFDLSGKKNFGISYLGRDRLGQEVYLSLLSDWDLSTAFATASKPYLQL 120 Query: 121 RVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILTQVGRTLSKV 180 RVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILTQVGRTLSKV Sbjct: 121 RVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILTQVGRTLSKV 180 Query: 181 QQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRY 240 QQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRY Sbjct: 181 QQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRY 240 Query: 241 LLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRSTVLKDVLRTDRAHP 300 LLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRSTVLKDVLRTDRAHP Sbjct: 241 LLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRSTVLKDVLRTDRAHP 300 Query: 301 YYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMK 360 YYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMK Sbjct: 301 YYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMK 360 Query: 361 RLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAF 420 RLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAF Sbjct: 361 RLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAF 420 Query: 421 DDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADAGFGGHRGWPVRQRHMLRPAGGGGST 480 DDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADAGFGGHRGWPVRQRHMLRPAGGGGST Sbjct: 421 DDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADAGFGGHRGWPVRQRHMLRPAGGGGST 480 Query: 481 FEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLS 540 FEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLS Sbjct: 481 FEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLS 540 Query: 541 EPLLNSPDPLLSSFSHPDSPSSSSPPSTQEASPTGDMAVGSPLMQEVGSPKDPGKSLPPV 600 EPLLNSPDPLLSSFSHPDSPSSSSPPSTQEASPTGDMAVGSPLMQEVGSPKDPGKSLPPV Sbjct: 541 EPLLNSPDPLLSSFSHPDSPSSSSPPSTQEASPTGDMAVGSPLMQEVGSPKDPGKSLPPV 600 Query: 601 PPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVL 660 PPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVL Sbjct: 601 PPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVL 660 Query: 661 RRARALFADYLQSEVWDSEEGAEATAAS 688 RRARALFADYLQSEVWDSEEGAEATAAS Sbjct: 661 RRARALFADYLQSEVWDSEEGAEATAAS 688 >gi|13375952 TBC1 domain family, member 17 [Homo sapiens] Length = 648 Score = 187 bits (475), Expect = 3e-47 Identities = 100/245 (40%), Positives = 144/245 (58%), Gaps = 8/245 (3%) Query: 197 PPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMD 256 PP+++ E+ ++ EG+L + EL+ RI+ GG+ PSLR+ W++LL T E Sbjct: 279 PPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKA 338 Query: 257 YMKRKSREYEQLKSEWAQRANPED------LEFIRSTVLKDVLRTDRAHPYYAGPEDGPH 310 ++++K+ EY ++K +W + +PE L RS + +DV RTDR + +Y GPE+ P Sbjct: 339 HIRKKTDEYFRMKLQW-KSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPEN-PG 396 Query: 311 LRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDG 370 L L+D+L TY + H + Y QGMSDL SPIL V+ +E AF CFCG M+ + NF Sbjct: 397 LGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQ 456 Query: 371 RAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVT 430 M + L LLLR DP +L + L FC+RWLL+ KREF F D LR+ EV Sbjct: 457 ETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVL 516 Query: 431 WSSLP 435 W+ LP Sbjct: 517 WTGLP 521 Score = 34.3 bits (77), Expect = 0.40 Identities = 25/63 (39%), Positives = 31/63 (49%), Gaps = 7/63 (11%) Query: 604 GLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRA 663 GLP P N +L C AIL RD +M +G NE+ H + L K + VL RA Sbjct: 519 GLPGP------NLHLLVAC-AILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRA 571 Query: 664 RAL 666 AL Sbjct: 572 EAL 574 >gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens] Length = 682 Score = 179 bits (455), Expect = 6e-45 Identities = 95/245 (38%), Positives = 141/245 (57%), Gaps = 6/245 (2%) Query: 196 KPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERM 255 + P+S E+ ++ EG++ + ++ I+ GG+ +LRK W++LL +P T ER Sbjct: 305 REPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERT 364 Query: 256 DYMKRKSREYEQLKSEWAQRANPED-----LEFIRSTVLKDVLRTDRAHPYYAGPEDGPH 310 K+K+ EY ++K +W + ++ L RS + KDV RTDR + +Y G +D P Sbjct: 365 QLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEG-QDNPG 423 Query: 311 LRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDG 370 L LHD+L TY + + Y QGMSDL SP+L VM++E AF CF M ++ NF Sbjct: 424 LILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQM 483 Query: 371 RAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVT 430 + M T+ L LLR D F YL+ + L+FC+RWLL+ KREF+F D LR+ EV Sbjct: 484 QGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVM 543 Query: 431 WSSLP 435 W+ LP Sbjct: 544 WTELP 548 Score = 33.1 bits (74), Expect = 0.88 Identities = 17/50 (34%), Positives = 25/50 (50%) Query: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666 F L LC AIL + IM +NE+ H + L K + +L +A A+ Sbjct: 552 FHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAI 601 >gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens] Length = 696 Score = 179 bits (455), Expect = 6e-45 Identities = 95/245 (38%), Positives = 141/245 (57%), Gaps = 6/245 (2%) Query: 196 KPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERM 255 + P+S E+ ++ EG++ + ++ I+ GG+ +LRK W++LL +P T ER Sbjct: 319 REPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERT 378 Query: 256 DYMKRKSREYEQLKSEWAQRANPED-----LEFIRSTVLKDVLRTDRAHPYYAGPEDGPH 310 K+K+ EY ++K +W + ++ L RS + KDV RTDR + +Y G +D P Sbjct: 379 QLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEG-QDNPG 437 Query: 311 LRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDG 370 L LHD+L TY + + Y QGMSDL SP+L VM++E AF CF M ++ NF Sbjct: 438 LILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQM 497 Query: 371 RAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVT 430 + M T+ L LLR D F YL+ + L+FC+RWLL+ KREF+F D LR+ EV Sbjct: 498 QGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVM 557 Query: 431 WSSLP 435 W+ LP Sbjct: 558 WTELP 562 Score = 33.1 bits (74), Expect = 0.88 Identities = 17/50 (34%), Positives = 25/50 (50%) Query: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666 F L LC AIL + IM +NE+ H + L K + +L +A A+ Sbjct: 566 FHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAI 615 >gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens] Length = 713 Score = 179 bits (455), Expect = 6e-45 Identities = 95/245 (38%), Positives = 141/245 (57%), Gaps = 6/245 (2%) Query: 196 KPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERM 255 + P+S E+ ++ EG++ + ++ I+ GG+ +LRK W++LL +P T ER Sbjct: 336 REPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERT 395 Query: 256 DYMKRKSREYEQLKSEWAQRANPED-----LEFIRSTVLKDVLRTDRAHPYYAGPEDGPH 310 K+K+ EY ++K +W + ++ L RS + KDV RTDR + +Y G +D P Sbjct: 396 QLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEG-QDNPG 454 Query: 311 LRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDG 370 L LHD+L TY + + Y QGMSDL SP+L VM++E AF CF M ++ NF Sbjct: 455 LILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQM 514 Query: 371 RAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVT 430 + M T+ L LLR D F YL+ + L+FC+RWLL+ KREF+F D LR+ EV Sbjct: 515 QGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVM 574 Query: 431 WSSLP 435 W+ LP Sbjct: 575 WTELP 579 Score = 33.1 bits (74), Expect = 0.88 Identities = 17/50 (34%), Positives = 25/50 (50%) Query: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666 F L LC AIL + IM +NE+ H + L K + +L +A A+ Sbjct: 583 FHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAI 632 >gi|33563376 TBC1 domain family, member 16 [Homo sapiens] Length = 767 Score = 153 bits (386), Expect = 6e-37 Identities = 91/236 (38%), Positives = 128/236 (54%), Gaps = 6/236 (2%) Query: 207 YLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYE 266 +LN GQ+ +LR I+ GG++ S+R VW +LL Y T ER +K +EY Sbjct: 404 HLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYS 463 Query: 267 QLKSEWAQRANPEDLEFIRS---TVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAV 323 +++ + E F R+ TV KDV+RTDR + ++ G ED P++ ++ +L YAV Sbjct: 464 EIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRG-EDNPNVESMRRILLNYAV 522 Query: 324 THPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLL 383 +P V Y QGMSDL +PILA + E F CF G+M+ P M + +L+ L Sbjct: 523 YNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLREL 582 Query: 384 LRHADPDFYQYLQEAGADDL--FFCYRWLLLELKREFAFDDALRMLEVTWSSLPPD 437 LR FYQ+L G D L FC+RWLLL KREF +ALR+ E W+ D Sbjct: 583 LRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTD 638 Score = 35.4 bits (80), Expect = 0.18 Identities = 17/54 (31%), Positives = 31/54 (57%) Query: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARALFADY 670 F LF+C+AI+ + D ++ L +++ +HF L + VLR+AR+L + Sbjct: 640 FHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQF 693 >gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo sapiens] Length = 1006 Score = 110 bits (276), Expect = 3e-24 Identities = 55/145 (37%), Positives = 88/145 (60%), Gaps = 6/145 (4%) Query: 290 KDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEG 349 KDV R DR + Y+ P +L L D++ +Y H V Y QGM DL +P+L +D++ Sbjct: 799 KDVQRCDRNYWYFTPP----NLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQ 854 Query: 350 HAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAG-ADDLFFCYR 408 A+ CF +MKR++ NF P+G AM T FA+++ L++ D + ++ + + G +FCYR Sbjct: 855 LAYSCFSHLMKRMSQNF-PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 913 Query: 409 WLLLELKREFAFDDALRMLEVTWSS 433 W LL+ KRE ++D + EV W++ Sbjct: 914 WFLLDFKRELLYEDVFAVWEVIWAA 938 Score = 43.1 bits (100), Expect = 9e-04 Identities = 19/54 (35%), Positives = 32/54 (59%) Query: 219 ELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEW 272 EL ++Y+GG+E +RK VW +LL Y G++ +E + Y+Q+ +EW Sbjct: 557 ELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEW 610 Score = 35.0 bits (79), Expect = 0.23 Identities = 16/50 (32%), Positives = 28/50 (56%) Query: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666 F+LF+ LA++ +R+ I N +D+ ++ F+ H +LR AR L Sbjct: 946 FVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDL 995 >gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo sapiens] Length = 1051 Score = 110 bits (276), Expect = 3e-24 Identities = 55/145 (37%), Positives = 88/145 (60%), Gaps = 6/145 (4%) Query: 290 KDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEG 349 KDV R DR + Y+ P +L L D++ +Y H V Y QGM DL +P+L +D++ Sbjct: 844 KDVQRCDRNYWYFTPP----NLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQ 899 Query: 350 HAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAG-ADDLFFCYR 408 A+ CF +MKR++ NF P+G AM T FA+++ L++ D + ++ + + G +FCYR Sbjct: 900 LAYSCFSHLMKRMSQNF-PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 958 Query: 409 WLLLELKREFAFDDALRMLEVTWSS 433 W LL+ KRE ++D + EV W++ Sbjct: 959 WFLLDFKRELLYEDVFAVWEVIWAA 983 Score = 43.1 bits (100), Expect = 9e-04 Identities = 19/54 (35%), Positives = 32/54 (59%) Query: 219 ELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEW 272 EL ++Y+GG+E +RK VW +LL Y G++ +E + Y+Q+ +EW Sbjct: 602 ELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEW 655 Score = 35.0 bits (79), Expect = 0.23 Identities = 16/50 (32%), Positives = 28/50 (56%) Query: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666 F+LF+ LA++ +R+ I N +D+ ++ F+ H +LR AR L Sbjct: 991 FVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDL 1040 >gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sapiens] Length = 1032 Score = 107 bits (268), Expect = 3e-23 Identities = 54/145 (37%), Positives = 85/145 (58%), Gaps = 6/145 (4%) Query: 290 KDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEG 349 KDV R DR + Y+ +L L +++ +Y H ++ Y QGM DL +P+L ++D E Sbjct: 825 KDVQRCDRNYWYFTPA----NLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEA 880 Query: 350 HAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAG-ADDLFFCYR 408 AF CF +MKR+ NF P G AM T FA+++ L++ D + ++ + + G +FCYR Sbjct: 881 LAFSCFTELMKRMNQNF-PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 939 Query: 409 WLLLELKREFAFDDALRMLEVTWSS 433 W LL+ KRE +DD + E W++ Sbjct: 940 WFLLDFKRELVYDDVFLVWETIWAA 964 Score = 44.7 bits (104), Expect = 3e-04 Identities = 22/50 (44%), Positives = 30/50 (60%), Gaps = 1/50 (2%) Query: 207 YLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMD 256 YL+ E LRL IY+GG++P +RK VW +LL Y G+T ER + Sbjct: 542 YLHDSTSYEEQELLRL-IYYGGIQPEIRKAVWPFLLGHYQFGMTETERKE 590 Score = 40.4 bits (93), Expect = 0.006 Identities = 16/50 (32%), Positives = 33/50 (66%) Query: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666 ++LF+ LA++ +RD I+ N +D+ ++ F+ + +H+ +VL+ AR L Sbjct: 972 YVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDL 1021 >gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sapiens] Length = 1093 Score = 107 bits (268), Expect = 3e-23 Identities = 54/145 (37%), Positives = 85/145 (58%), Gaps = 6/145 (4%) Query: 290 KDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEG 349 KDV R DR + Y+ +L L +++ +Y H ++ Y QGM DL +P+L ++D E Sbjct: 886 KDVQRCDRNYWYFTPA----NLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEA 941 Query: 350 HAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAG-ADDLFFCYR 408 AF CF +MKR+ NF P G AM T FA+++ L++ D + ++ + + G +FCYR Sbjct: 942 LAFSCFTELMKRMNQNF-PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 1000 Query: 409 WLLLELKREFAFDDALRMLEVTWSS 433 W LL+ KRE +DD + E W++ Sbjct: 1001 WFLLDFKRELVYDDVFLVWETIWAA 1025 Score = 50.4 bits (119), Expect = 5e-06 Identities = 26/66 (39%), Positives = 37/66 (56%), Gaps = 1/66 (1%) Query: 207 YLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYE 266 YL+ E LRL IY+GG++P +RK VW +LL Y G+T ER + ++ Y Sbjct: 542 YLHDSTSYEEQELLRL-IYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYA 600 Query: 267 QLKSEW 272 Q +EW Sbjct: 601 QTMAEW 606 Score = 40.4 bits (93), Expect = 0.006 Identities = 16/50 (32%), Positives = 33/50 (66%) Query: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666 ++LF+ LA++ +RD I+ N +D+ ++ F+ + +H+ +VL+ AR L Sbjct: 1033 YVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDL 1082 >gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sapiens] Length = 1087 Score = 107 bits (268), Expect = 3e-23 Identities = 54/145 (37%), Positives = 85/145 (58%), Gaps = 6/145 (4%) Query: 290 KDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEG 349 KDV R DR + Y+ +L L +++ +Y H ++ Y QGM DL +P+L ++D E Sbjct: 880 KDVQRCDRNYWYFTPA----NLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEA 935 Query: 350 HAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAG-ADDLFFCYR 408 AF CF +MKR+ NF P G AM T FA+++ L++ D + ++ + + G +FCYR Sbjct: 936 LAFSCFTELMKRMNQNF-PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 994 Query: 409 WLLLELKREFAFDDALRMLEVTWSS 433 W LL+ KRE +DD + E W++ Sbjct: 995 WFLLDFKRELVYDDVFLVWETIWAA 1019 Score = 44.7 bits (104), Expect = 3e-04 Identities = 22/50 (44%), Positives = 30/50 (60%), Gaps = 1/50 (2%) Query: 207 YLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMD 256 YL+ E LRL IY+GG++P +RK VW +LL Y G+T ER + Sbjct: 597 YLHDSTSYEEQELLRL-IYYGGIQPEIRKAVWPFLLGHYQFGMTETERKE 645 Score = 40.4 bits (93), Expect = 0.006 Identities = 16/50 (32%), Positives = 33/50 (66%) Query: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666 ++LF+ LA++ +RD I+ N +D+ ++ F+ + +H+ +VL+ AR L Sbjct: 1027 YVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDL 1076 >gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sapiens] Length = 1148 Score = 107 bits (268), Expect = 3e-23 Identities = 54/145 (37%), Positives = 85/145 (58%), Gaps = 6/145 (4%) Query: 290 KDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEG 349 KDV R DR + Y+ +L L +++ +Y H ++ Y QGM DL +P+L ++D E Sbjct: 941 KDVQRCDRNYWYFTPA----NLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEA 996 Query: 350 HAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAG-ADDLFFCYR 408 AF CF +MKR+ NF P G AM T FA+++ L++ D + ++ + + G +FCYR Sbjct: 997 LAFSCFTELMKRMNQNF-PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 1055 Query: 409 WLLLELKREFAFDDALRMLEVTWSS 433 W LL+ KRE +DD + E W++ Sbjct: 1056 WFLLDFKRELVYDDVFLVWETIWAA 1080 Score = 50.4 bits (119), Expect = 5e-06 Identities = 26/66 (39%), Positives = 37/66 (56%), Gaps = 1/66 (1%) Query: 207 YLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYE 266 YL+ E LRL IY+GG++P +RK VW +LL Y G+T ER + ++ Y Sbjct: 597 YLHDSTSYEEQELLRL-IYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYA 655 Query: 267 QLKSEW 272 Q +EW Sbjct: 656 QTMAEW 661 Score = 40.4 bits (93), Expect = 0.006 Identities = 16/50 (32%), Positives = 33/50 (66%) Query: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666 ++LF+ LA++ +RD I+ N +D+ ++ F+ + +H+ +VL+ AR L Sbjct: 1088 YVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDL 1137 >gi|114688046 TBC1 domain family, member 4 [Homo sapiens] Length = 1298 Score = 60.5 bits (145), Expect = 5e-09 Identities = 50/204 (24%), Positives = 86/204 (42%), Gaps = 16/204 (7%) Query: 228 GVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRST 287 GV S R +W++L + Y R +Q + + + + L + Sbjct: 918 GVPKSRRGEIWQFLA------------LQYRLRHRLPNKQQPPDISYKELLKQLTAQQHA 965 Query: 288 VLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDH 347 +L D+ RT HPY++ + GP +L +LL Y++ +V YCQG+S +A +L M Sbjct: 966 ILVDLGRTFPTHPYFS-VQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSE 1024 Query: 348 EGHAFVCFCGIMKRLA--ANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFF 405 E AF +M L + PD ++ + L LL D Y +L+E + Sbjct: 1025 E-QAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLY 1083 Query: 406 CYRWLLLELKREFAFDDALRMLEV 429 W L +F+ R+ ++ Sbjct: 1084 AAPWFLTLFASQFSLGFVARVFDI 1107 >gi|190014603 TBC1 domain family, member 13 [Homo sapiens] Length = 400 Score = 59.7 bits (143), Expect = 9e-09 Identities = 42/142 (29%), Positives = 62/142 (43%), Gaps = 18/142 (12%) Query: 310 HLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVM---------DH-EGHAFVCFCGIM 359 H + +L YA +P ++Y QGM+++ P+ +H E F CF +M Sbjct: 207 HWEVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNLM 266 Query: 360 KRLAANFHP---DGRAMAT-KFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELK 415 + NF D + T K + L+ D + Y LQE FF +RWL L L Sbjct: 267 AEIRDNFIKSLDDSQCGITYKMEKVYSTLKDKDVELYLKLQEQNIKPQFFAFRWLTLLLS 326 Query: 416 REFAFDDALRMLEVTWSSLPPD 437 +EF D +R+ W SL D Sbjct: 327 QEFLLPDVIRI----WDSLFAD 344 >gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 [Homo sapiens] Length = 1168 Score = 56.2 bits (134), Expect = 1e-07 Identities = 51/237 (21%), Positives = 97/237 (40%), Gaps = 30/237 (12%) Query: 221 RLRIYHGGVEPSLRKV--VWRYLLNV----------------YPDGLTGRERMDYMKRKS 262 RL++ + + P L++V VW +L+ G+ R + K + Sbjct: 755 RLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLA 814 Query: 263 REYEQLKSEWAQRANPEDLEFI---------RSTVLKDVLRTDRAHPYYAGPEDGPHLRA 313 ++ LK ++ + P+D+ + + +L D+ RT HPY++ L + Sbjct: 815 EQFH-LKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQL-S 872 Query: 314 LHDLLTTYAVTHPQVSYCQGMSDLASPILAVM-DHEGHAFVCFCGIMKRLAANFHPDGRA 372 L+++L Y++ +V YCQG+S +A +L M + E + F L + PD Sbjct: 873 LYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMII 932 Query: 373 MATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEV 429 + + L LL D Y +L+E + W L +F R+ ++ Sbjct: 933 LQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDM 989 >gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] Length = 1069 Score = 55.8 bits (133), Expect = 1e-07 Identities = 53/205 (25%), Positives = 86/205 (41%), Gaps = 25/205 (12%) Query: 216 RPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQR 275 RP++L + GV +LR VW+ L G D++ K R + Sbjct: 555 RPKQLS-SLVRNGVPEALRGEVWQLL--------AGCHNNDHLVEKYRIL-------ITK 598 Query: 276 ANPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMS 335 +P+D S + +D+ RT AH Y+ G +L+ + Y+V ++ YCQG S Sbjct: 599 ESPQD-----SAITRDINRTFPAHDYFKDT-GGDGQDSLYKICKAYSVYDEEIGYCQGQS 652 Query: 336 DLASPILAVMDHEGHAFVCFCGIM--KRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQ 393 LA+ +L M E AF IM L F + + KF L+ L++ PD Y Sbjct: 653 FLAAVLLLHMPEE-QAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYN 711 Query: 394 YLQEAGADDLFFCYRWLLLELKREF 418 + + + + +W L +F Sbjct: 712 HFLDISLEAHMYASQWFLTLFTAKF 736 >gi|23503283 TBC1 domain family, member 21 [Homo sapiens] Length = 336 Score = 55.8 bits (133), Expect = 1e-07 Identities = 52/248 (20%), Positives = 105/248 (42%), Gaps = 13/248 (5%) Query: 196 KPPLSDAEFHTYLNHEGQLSRPEE-LRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRER 254 KPP+ E+ ++ + G L++ + + + I G+ P +R W++L + + ER Sbjct: 24 KPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHPFVRTEAWKFLTGYFSWQSSQDER 83 Query: 255 MDYMKRKSREYEQLKSEWAQRANP------EDLEFIRSTVLKDVLRTDRAHPYYAGPEDG 308 + + + Y+ L + ++ P + R+ + +D+ + P D Sbjct: 84 LTVDSMRRKNYKAL-CQMYEKIQPLLENLHRNFTETRNNIARDIQKIYDKDPLGNVLIDK 142 Query: 309 PHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHP 368 L + LL +Y V + Q Y QG ++ +++H+ F F +++ + Sbjct: 143 KRLEKI--LLLSY-VCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLFQFFLQK-TEHSCV 198 Query: 369 DGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREF-AFDDALRML 427 +A L L+ DP F ++L+ GA + + W +R F +FDD R+ Sbjct: 199 INIGVAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSFDDVWRLW 258 Query: 428 EVTWSSLP 435 EV + P Sbjct: 259 EVLLTGKP 266 >gi|167614488 TBC1 domain family, member 10B [Homo sapiens] Length = 808 Score = 53.1 bits (126), Expect = 8e-07 Identities = 55/225 (24%), Positives = 95/225 (42%), Gaps = 22/225 (9%) Query: 207 YLNHEGQLSRP-EELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREY 265 + N + LSR ++++LR G+ SLR W+YL N +E ++ K E Sbjct: 339 FSNWDKWLSRRFQKVKLRC-RKGIPSSLRAKAWQYLSN-------SKELLEQNPGKFEEL 390 Query: 266 EQLKSEWAQRANPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTH 325 E+ + P+ L+ I KD+ R H +A G + L+ +L Y + Sbjct: 391 ERAPGD------PKWLDVIE----KDLHRQFPFHEMFAA-RGGHGQQDLYRILKAYTIYR 439 Query: 326 PQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDG-RAMATKFAHLKLLL 384 P YCQ + +A+ +L M E AF C I + ++ G A+ LL Sbjct: 440 PDEGYCQAQAPVAAVLLMHMPAE-QAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALL 498 Query: 385 RHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEV 429 R A P +++L+ D + + W + R + LR+ ++ Sbjct: 499 RRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDM 543 >gi|40068063 TBC1 domain family, member 22B [Homo sapiens] Length = 505 Score = 51.2 bits (121), Expect = 3e-06 Identities = 51/231 (22%), Positives = 89/231 (38%), Gaps = 29/231 (12%) Query: 228 GVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRST 287 GV +R + WR LL+ Y T R ++ ++RK EY ++ N E + Sbjct: 210 GVPREVRPITWR-LLSGYLPANTERRKLT-LQRKREEYFGFIEQYYDSRNEEHHQDTYRQ 267 Query: 288 VLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVM-- 345 + D+ RT+ P + P +L +A+ HP Y QG++DL +P V Sbjct: 268 IHIDIPRTNPLIPLFQQPLVQ---EIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLS 324 Query: 346 ---------------------DHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLL 384 E +F C ++ + N+ + K L+ L+ Sbjct: 325 EYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELV 384 Query: 385 RHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLP 435 D + + + + L F +RW+ L RE +R+ + T+ S P Sbjct: 385 SRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWD-TYQSEP 434 >gi|148806902 TBC1 domain family, member 12 [Homo sapiens] Length = 775 Score = 51.2 bits (121), Expect = 3e-06 Identities = 45/211 (21%), Positives = 85/211 (40%), Gaps = 16/211 (7%) Query: 228 GVEPSLRKVVWRYL----LNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEF 283 G+ PS+R VW LN+ P E + +++E + SE + + E + Sbjct: 484 GLPPSVRGKVWSLAVGNELNITP------ELYEIFLSRAKERWKSFSETSSENDTEGVSV 537 Query: 284 IRSTVLKDVLRTDRAHPY---YAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP 340 ++++ D + + Y + GP+ LH +L Y P V Y QGMS +A+ Sbjct: 538 ADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAV 597 Query: 341 ILAVMDHEGHAFVCFCGIMKR--LAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEA 398 ++ ++ E AF+ F ++ + A F D M FA ++ + + + Sbjct: 598 LILNLE-EADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSY 656 Query: 399 GADDLFFCYRWLLLELKREFAFDDALRMLEV 429 + W+ + D A R+ +V Sbjct: 657 SLTPDIYLIDWIFTLYSKSLPLDLACRVWDV 687 >gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo sapiens] Length = 815 Score = 50.8 bits (120), Expect = 4e-06 Identities = 50/212 (23%), Positives = 85/212 (40%), Gaps = 27/212 (12%) Query: 210 HEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPD-GLTGRERMDYMKRKSREYEQL 268 H +RP+ L + GV +LR VW+ L + + + R R+ K ++E Sbjct: 521 HSNLGARPKGLSTLV-KSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITKDSAQE---- 575 Query: 269 KSEWAQRANPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQV 328 S + +D+ RT AH Y+ G +L+ + Y+V + Sbjct: 576 -----------------SVITRDIHRTFPAHDYFKDT-GGDGQESLYKICKAYSVYDEDI 617 Query: 329 SYCQGMSDLASPILAVMDHEGHAFVCFCGIM--KRLAANFHPDGRAMATKFAHLKLLLRH 386 YCQG S LA+ +L M E AF IM L + + + KF L+ L++ Sbjct: 618 GYCQGQSFLAAVLLLHMPEE-QAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQE 676 Query: 387 ADPDFYQYLQEAGADDLFFCYRWLLLELKREF 418 PD + + + + + +W L +F Sbjct: 677 QLPDLHSHFSDLNLEAHMYASQWFLTLFTAKF 708 >gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens] Length = 413 Score = 50.4 bits (119), Expect = 5e-06 Identities = 50/209 (23%), Positives = 83/209 (39%), Gaps = 10/209 (4%) Query: 228 GVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFI--- 284 G+ PS+R VW L + + E D +++E + S ED F Sbjct: 121 GIPPSVRGKVWS--LAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAAD 178 Query: 285 RSTVLKDV-LRTDRAHPYYA-GPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPIL 342 R L+ + L R P + GP+ LH +L Y P V Y QGMS +A+ ++ Sbjct: 179 REASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLI 238 Query: 343 AVMDHEGHAFVCFCGIMKR--LAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA 400 +D AF+ F ++ + A F D M T FA ++ P + + ++ Sbjct: 239 LNLD-TADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNL 297 Query: 401 DDLFFCYRWLLLELKREFAFDDALRMLEV 429 + W+ + D A R+ +V Sbjct: 298 TPDIYLIDWIFTLYSKSLPLDLACRIWDV 326 >gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens] Length = 693 Score = 50.4 bits (119), Expect = 5e-06 Identities = 50/209 (23%), Positives = 83/209 (39%), Gaps = 10/209 (4%) Query: 228 GVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFI--- 284 G+ PS+R VW L + + E D +++E + S ED F Sbjct: 401 GIPPSVRGKVWS--LAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAAD 458 Query: 285 RSTVLKDV-LRTDRAHPYYA-GPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPIL 342 R L+ + L R P + GP+ LH +L Y P V Y QGMS +A+ ++ Sbjct: 459 REASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLI 518 Query: 343 AVMDHEGHAFVCFCGIMKR--LAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA 400 +D AF+ F ++ + A F D M T FA ++ P + + ++ Sbjct: 519 LNLD-TADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNL 577 Query: 401 DDLFFCYRWLLLELKREFAFDDALRMLEV 429 + W+ + D A R+ +V Sbjct: 578 TPDIYLIDWIFTLYSKSLPLDLACRIWDV 606 >gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens] Length = 693 Score = 50.4 bits (119), Expect = 5e-06 Identities = 50/209 (23%), Positives = 83/209 (39%), Gaps = 10/209 (4%) Query: 228 GVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFI--- 284 G+ PS+R VW L + + E D +++E + S ED F Sbjct: 401 GIPPSVRGKVWS--LAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAAD 458 Query: 285 RSTVLKDV-LRTDRAHPYYA-GPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPIL 342 R L+ + L R P + GP+ LH +L Y P V Y QGMS +A+ ++ Sbjct: 459 REASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLI 518 Query: 343 AVMDHEGHAFVCFCGIMKR--LAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA 400 +D AF+ F ++ + A F D M T FA ++ P + + ++ Sbjct: 519 LNLD-TADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNL 577 Query: 401 DDLFFCYRWLLLELKREFAFDDALRMLEV 429 + W+ + D A R+ +V Sbjct: 578 TPDIYLIDWIFTLYSKSLPLDLACRIWDV 606 >gi|38348348 TBC1 domain family, member 10C [Homo sapiens] Length = 446 Score = 49.7 bits (117), Expect = 9e-06 Identities = 37/141 (26%), Positives = 59/141 (41%), Gaps = 3/141 (2%) Query: 287 TVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMD 346 T+ +D+ R H + P+ G + L +L Y + P+ YCQ +A+ +L + Sbjct: 134 TIGRDLHRQFPLHEMFVSPQ-GHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLP 192 Query: 347 HEGHAFVCFCGIMK-RLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFF 405 E AF C I + L + P A+ LLR P +++LQ+ G L + Sbjct: 193 PE-EAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLY 251 Query: 406 CYRWLLLELKREFAFDDALRM 426 W L R F LR+ Sbjct: 252 LPEWFLCLFARSLPFPTVLRV 272 >gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sapiens] Length = 2161 Score = 48.1 bits (113), Expect = 3e-05 Identities = 57/216 (26%), Positives = 76/216 (35%), Gaps = 40/216 (18%) Query: 435 PPDPPEHEV--ELVGPPSQVADAGFGGHRGW----------PVRQRHMLRPAGGGGSTFE 482 PP PPE E PP ++A RGW H GGGGS+ Sbjct: 1020 PPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQG 1079 Query: 483 DAVDHL------------ATASQGPGGGGRLLRQASLDGLQQLRDNMG---SRRDPLVQL 527 A+ + A G G G L++Q ++G Q + S P Sbjct: 1080 PALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGGGLPPAPSPTSPASPQ 1139 Query: 528 PHPAALISSKSLSEPL----LNSPDPLLSSFSHPDSPSSSSPPSTQEASPTGDMAVGSPL 583 P PA S+ S P+ + +P S S S + + PP+ E PTG G Sbjct: 1140 PPPAVAAPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPE--PTGGGGGG--- 1194 Query: 584 MQEVGSPKDPGKSLPPVPPMGLPPPQEFGRGNPFML 619 GS P ++ PVPP P P P L Sbjct: 1195 ----GSSPSPAPAMSPVPPSPSPVPTPASPSGPATL 1226 Score = 32.0 bits (71), Expect = 2.0 Identities = 27/86 (31%), Positives = 34/86 (39%), Gaps = 27/86 (31%) Query: 523 PLVQLPHPAALISSKS----LSEPLLNSPDPL--LSSFSHPDSPSSSSPPSTQEASPTGD 576 PL+ LP PA + + EPL P PL +SF P+SP + PP +P Sbjct: 1543 PLLVLPPPAPSVDVEDGEFLFVEPL---PPPLEFSNSFEKPESPLTPGPPHPLPDTPA-- 1597 Query: 577 MAVGSPLMQEVGSPKDPGKSLPPVPP 602 P LPPVPP Sbjct: 1598 ----------------PATPLPPVPP 1607 Score = 29.6 bits (65), Expect = 9.7 Identities = 30/116 (25%), Positives = 42/116 (36%), Gaps = 23/116 (19%) Query: 495 PGGGGRLLRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLSEPLLNSPDPLLSSF 554 P G G +LRQ S+ + R + P A+ S+SLS P P Sbjct: 879 PPGPGLMLRQKSIGAAEDDRPYLA-----------PPAMKFSRSLSVPGSEDIPP----- 922 Query: 555 SHPDSPSSSSPPSTQEASPTGDMAVGSPLMQEVGSPKDPGKS--LPPVPPMGLPPP 608 P ++SPP ++P + G G P +PG LP P P Sbjct: 923 -----PPTTSPPEPPYSTPPVPSSSGRLTPSPRGGPFNPGSGGPLPASSPASFDGP 973 >gi|13994322 TBC1 domain family, member 10A [Homo sapiens] Length = 508 Score = 47.8 bits (112), Expect = 3e-05 Identities = 47/213 (22%), Positives = 88/213 (41%), Gaps = 21/213 (9%) Query: 218 EELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRAN 277 +++RLR G + PSLR W+YL G+ ++ K E + + Sbjct: 102 KKIRLRCQKG-IPPSLRGRAWQYLSG-------GKVKLQQNPGKFDELDM---------S 144 Query: 278 PEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDL 337 P D +++ + +D+ R H + G + L +L Y + P+ YCQ + + Sbjct: 145 PGDPKWL-DVIERDLHRQFPFHEMFVS-RGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPI 202 Query: 338 ASPILAVMDHEGHAFVCFCGIMKRLAANFHPDG-RAMATKFAHLKLLLRHADPDFYQYLQ 396 A+ +L M E AF C I ++ ++ + A+ L LL+ P +++L Sbjct: 203 AAVLLMHMPAE-QAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLS 261 Query: 397 EAGADDLFFCYRWLLLELKREFAFDDALRMLEV 429 D L + W + R + LR+ ++ Sbjct: 262 RQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDM 294 >gi|229577000 ecotropic viral integration site 5-like isoform 1 [Homo sapiens] Length = 805 Score = 47.4 bits (111), Expect = 5e-05 Identities = 46/216 (21%), Positives = 83/216 (38%), Gaps = 25/216 (11%) Query: 216 RPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQR 275 R E+L + G+ R +VW+ L + M K++ E LK Sbjct: 103 RKEKLLKELIRKGIPHHFRAIVWQLLCSATD-----------MPVKNQYSELLKM----- 146 Query: 276 ANPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMS 335 ++P + +D+ RT H ++ G +D L +++ Y++ +V YCQG + Sbjct: 147 SSP-----CEKLIRRDIARTYPEHEFFKG-QDSLGQEVLFNVMKAYSLVDREVGYCQGSA 200 Query: 336 DLASPILAVMDHEGHAFVCFCGIMK--RLAANFHPDGRAMATKFAHLKLLLRHADPDFYQ 393 + +L M E AF F +M+ RL F P + + +L+ PD Sbjct: 201 FIVGLLLMQMPEE-EAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNT 259 Query: 394 YLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEV 429 + + + W L F A R+ ++ Sbjct: 260 HFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDI 295 >gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo sapiens] Length = 794 Score = 47.4 bits (111), Expect = 5e-05 Identities = 46/216 (21%), Positives = 83/216 (38%), Gaps = 25/216 (11%) Query: 216 RPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQR 275 R E+L + G+ R +VW+ L + M K++ E LK Sbjct: 103 RKEKLLKELIRKGIPHHFRAIVWQLLCSATD-----------MPVKNQYSELLKM----- 146 Query: 276 ANPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMS 335 ++P + +D+ RT H ++ G +D L +++ Y++ +V YCQG + Sbjct: 147 SSP-----CEKLIRRDIARTYPEHEFFKG-QDSLGQEVLFNVMKAYSLVDREVGYCQGSA 200 Query: 336 DLASPILAVMDHEGHAFVCFCGIMK--RLAANFHPDGRAMATKFAHLKLLLRHADPDFYQ 393 + +L M E AF F +M+ RL F P + + +L+ PD Sbjct: 201 FIVGLLLMQMPEE-EAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNT 259 Query: 394 YLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEV 429 + + + W L F A R+ ++ Sbjct: 260 HFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDI 295 >gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo sapiens] Length = 761 Score = 47.0 bits (110), Expect = 6e-05 Identities = 47/171 (27%), Positives = 82/171 (47%), Gaps = 17/171 (9%) Query: 228 GVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRST 287 G+ R+ VW L + Y + +D+ K ++ + +R+NP+D + + Sbjct: 86 GIPKEWRRKVWLTLADHYLHSIA----IDWDKT-------MRFTFNERSNPDD-DSMGIQ 133 Query: 288 VLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMD- 346 ++KD+ RT + Y G E L +L YA + V YCQG + LA+ IL VM+ Sbjct: 134 IVKDLHRTGCSS--YCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEG 191 Query: 347 HEGHAFVCFCGIMKRL--AANFHPDGRAMATKFAHLKLLLRHADPDFYQYL 395 +EG A ++ ++ + F + RA++ A + LLR P+ Q+L Sbjct: 192 NEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHL 242 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.136 0.412 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 31,053,197 Number of Sequences: 37866 Number of extensions: 1679629 Number of successful extensions: 10535 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 97 Number of HSP's successfully gapped in prelim test: 391 Number of HSP's that attempted gapping in prelim test: 8807 Number of HSP's gapped (non-prelim): 1822 length of query: 688 length of database: 18,247,518 effective HSP length: 109 effective length of query: 579 effective length of database: 14,120,124 effective search space: 8175551796 effective search space used: 8175551796 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.