Guide to the Human Genome
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Search of human proteins with 54607014

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|54607014 TBC1 domain family, member 25 [Homo sapiens]
         (688 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|54607014 TBC1 domain family, member 25 [Homo sapiens]             1397   0.0  
gi|13375952 TBC1 domain family, member 17 [Homo sapiens]              187   3e-47
gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]   179   6e-45
gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]   179   6e-45
gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]   179   6e-45
gi|33563376 TBC1 domain family, member 16 [Homo sapiens]              153   6e-37
gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo sa...   110   3e-24
gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo sa...   110   3e-24
gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sa...   107   3e-23
gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sa...   107   3e-23
gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sap...   107   3e-23
gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sap...   107   3e-23
gi|114688046 TBC1 domain family, member 4 [Homo sapiens]               60   5e-09
gi|190014603 TBC1 domain family, member 13 [Homo sapiens]              60   9e-09
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member...    56   1e-07
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]            56   1e-07
gi|23503283 TBC1 domain family, member 21 [Homo sapiens]               56   1e-07
gi|167614488 TBC1 domain family, member 10B [Homo sapiens]             53   8e-07
gi|40068063 TBC1 domain family, member 22B [Homo sapiens]              51   3e-06
gi|148806902 TBC1 domain family, member 12 [Homo sapiens]              51   3e-06
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo...    51   4e-06
gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]    50   5e-06
gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]    50   5e-06
gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]    50   5e-06
gi|38348348 TBC1 domain family, member 10C [Homo sapiens]              50   9e-06
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap...    48   3e-05
gi|13994322 TBC1 domain family, member 10A [Homo sapiens]              48   3e-05
gi|229577000 ecotropic viral integration site 5-like isoform 1 [...    47   5e-05
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H...    47   5e-05
gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo sapi...    47   6e-05

>gi|54607014 TBC1 domain family, member 25 [Homo sapiens]
          Length = 688

 Score = 1397 bits (3615), Expect = 0.0
 Identities = 688/688 (100%), Positives = 688/688 (100%)

Query: 1   MATASGASDLSGSGAPPPGVGAQAAAAAEEEEREVVRVRVKKCESFLPPEFRSFAVDPQI 60
           MATASGASDLSGSGAPPPGVGAQAAAAAEEEEREVVRVRVKKCESFLPPEFRSFAVDPQI
Sbjct: 1   MATASGASDLSGSGAPPPGVGAQAAAAAEEEEREVVRVRVKKCESFLPPEFRSFAVDPQI 60

Query: 61  TSLDVLQHILIRAFDLSGKKNFGISYLGRDRLGQEVYLSLLSDWDLSTAFATASKPYLQL 120
           TSLDVLQHILIRAFDLSGKKNFGISYLGRDRLGQEVYLSLLSDWDLSTAFATASKPYLQL
Sbjct: 61  TSLDVLQHILIRAFDLSGKKNFGISYLGRDRLGQEVYLSLLSDWDLSTAFATASKPYLQL 120

Query: 121 RVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILTQVGRTLSKV 180
           RVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILTQVGRTLSKV
Sbjct: 121 RVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILTQVGRTLSKV 180

Query: 181 QQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRY 240
           QQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRY
Sbjct: 181 QQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRY 240

Query: 241 LLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRSTVLKDVLRTDRAHP 300
           LLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRSTVLKDVLRTDRAHP
Sbjct: 241 LLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRSTVLKDVLRTDRAHP 300

Query: 301 YYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMK 360
           YYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMK
Sbjct: 301 YYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMK 360

Query: 361 RLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAF 420
           RLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAF
Sbjct: 361 RLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAF 420

Query: 421 DDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADAGFGGHRGWPVRQRHMLRPAGGGGST 480
           DDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADAGFGGHRGWPVRQRHMLRPAGGGGST
Sbjct: 421 DDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADAGFGGHRGWPVRQRHMLRPAGGGGST 480

Query: 481 FEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLS 540
           FEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLS
Sbjct: 481 FEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLS 540

Query: 541 EPLLNSPDPLLSSFSHPDSPSSSSPPSTQEASPTGDMAVGSPLMQEVGSPKDPGKSLPPV 600
           EPLLNSPDPLLSSFSHPDSPSSSSPPSTQEASPTGDMAVGSPLMQEVGSPKDPGKSLPPV
Sbjct: 541 EPLLNSPDPLLSSFSHPDSPSSSSPPSTQEASPTGDMAVGSPLMQEVGSPKDPGKSLPPV 600

Query: 601 PPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVL 660
           PPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVL
Sbjct: 601 PPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVL 660

Query: 661 RRARALFADYLQSEVWDSEEGAEATAAS 688
           RRARALFADYLQSEVWDSEEGAEATAAS
Sbjct: 661 RRARALFADYLQSEVWDSEEGAEATAAS 688


>gi|13375952 TBC1 domain family, member 17 [Homo sapiens]
          Length = 648

 Score =  187 bits (475), Expect = 3e-47
 Identities = 100/245 (40%), Positives = 144/245 (58%), Gaps = 8/245 (3%)

Query: 197 PPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMD 256
           PP+++ E+  ++  EG+L +  EL+ RI+ GG+ PSLR+  W++LL       T  E   
Sbjct: 279 PPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKA 338

Query: 257 YMKRKSREYEQLKSEWAQRANPED------LEFIRSTVLKDVLRTDRAHPYYAGPEDGPH 310
           ++++K+ EY ++K +W +  +PE       L   RS + +DV RTDR + +Y GPE+ P 
Sbjct: 339 HIRKKTDEYFRMKLQW-KSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPEN-PG 396

Query: 311 LRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDG 370
           L  L+D+L TY + H  + Y QGMSDL SPIL V+ +E  AF CFCG M+ +  NF    
Sbjct: 397 LGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQ 456

Query: 371 RAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVT 430
             M  +   L LLLR  DP    +L    +  L FC+RWLL+  KREF F D LR+ EV 
Sbjct: 457 ETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVL 516

Query: 431 WSSLP 435
           W+ LP
Sbjct: 517 WTGLP 521



 Score = 34.3 bits (77), Expect = 0.40
 Identities = 25/63 (39%), Positives = 31/63 (49%), Gaps = 7/63 (11%)

Query: 604 GLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRA 663
           GLP P      N  +L  C AIL   RD +M +G   NE+  H + L  K  +  VL RA
Sbjct: 519 GLPGP------NLHLLVAC-AILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRA 571

Query: 664 RAL 666
            AL
Sbjct: 572 EAL 574


>gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]
          Length = 682

 Score =  179 bits (455), Expect = 6e-45
 Identities = 95/245 (38%), Positives = 141/245 (57%), Gaps = 6/245 (2%)

Query: 196 KPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERM 255
           + P+S  E+   ++ EG++   + ++  I+ GG+  +LRK  W++LL  +P   T  ER 
Sbjct: 305 REPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERT 364

Query: 256 DYMKRKSREYEQLKSEWAQRANPED-----LEFIRSTVLKDVLRTDRAHPYYAGPEDGPH 310
              K+K+ EY ++K +W   +  ++     L   RS + KDV RTDR + +Y G +D P 
Sbjct: 365 QLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEG-QDNPG 423

Query: 311 LRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDG 370
           L  LHD+L TY +    + Y QGMSDL SP+L VM++E  AF CF   M ++  NF    
Sbjct: 424 LILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQM 483

Query: 371 RAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVT 430
           + M T+   L  LLR  D  F  YL+   +  L+FC+RWLL+  KREF+F D LR+ EV 
Sbjct: 484 QGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVM 543

Query: 431 WSSLP 435
           W+ LP
Sbjct: 544 WTELP 548



 Score = 33.1 bits (74), Expect = 0.88
 Identities = 17/50 (34%), Positives = 25/50 (50%)

Query: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666
           F L LC AIL   +  IM     +NE+  H + L  K  +  +L +A A+
Sbjct: 552 FHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAI 601


>gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]
          Length = 696

 Score =  179 bits (455), Expect = 6e-45
 Identities = 95/245 (38%), Positives = 141/245 (57%), Gaps = 6/245 (2%)

Query: 196 KPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERM 255
           + P+S  E+   ++ EG++   + ++  I+ GG+  +LRK  W++LL  +P   T  ER 
Sbjct: 319 REPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERT 378

Query: 256 DYMKRKSREYEQLKSEWAQRANPED-----LEFIRSTVLKDVLRTDRAHPYYAGPEDGPH 310
              K+K+ EY ++K +W   +  ++     L   RS + KDV RTDR + +Y G +D P 
Sbjct: 379 QLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEG-QDNPG 437

Query: 311 LRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDG 370
           L  LHD+L TY +    + Y QGMSDL SP+L VM++E  AF CF   M ++  NF    
Sbjct: 438 LILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQM 497

Query: 371 RAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVT 430
           + M T+   L  LLR  D  F  YL+   +  L+FC+RWLL+  KREF+F D LR+ EV 
Sbjct: 498 QGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVM 557

Query: 431 WSSLP 435
           W+ LP
Sbjct: 558 WTELP 562



 Score = 33.1 bits (74), Expect = 0.88
 Identities = 17/50 (34%), Positives = 25/50 (50%)

Query: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666
           F L LC AIL   +  IM     +NE+  H + L  K  +  +L +A A+
Sbjct: 566 FHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAI 615


>gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]
          Length = 713

 Score =  179 bits (455), Expect = 6e-45
 Identities = 95/245 (38%), Positives = 141/245 (57%), Gaps = 6/245 (2%)

Query: 196 KPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERM 255
           + P+S  E+   ++ EG++   + ++  I+ GG+  +LRK  W++LL  +P   T  ER 
Sbjct: 336 REPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERT 395

Query: 256 DYMKRKSREYEQLKSEWAQRANPED-----LEFIRSTVLKDVLRTDRAHPYYAGPEDGPH 310
              K+K+ EY ++K +W   +  ++     L   RS + KDV RTDR + +Y G +D P 
Sbjct: 396 QLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEG-QDNPG 454

Query: 311 LRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDG 370
           L  LHD+L TY +    + Y QGMSDL SP+L VM++E  AF CF   M ++  NF    
Sbjct: 455 LILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQM 514

Query: 371 RAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVT 430
           + M T+   L  LLR  D  F  YL+   +  L+FC+RWLL+  KREF+F D LR+ EV 
Sbjct: 515 QGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVM 574

Query: 431 WSSLP 435
           W+ LP
Sbjct: 575 WTELP 579



 Score = 33.1 bits (74), Expect = 0.88
 Identities = 17/50 (34%), Positives = 25/50 (50%)

Query: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666
           F L LC AIL   +  IM     +NE+  H + L  K  +  +L +A A+
Sbjct: 583 FHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAI 632


>gi|33563376 TBC1 domain family, member 16 [Homo sapiens]
          Length = 767

 Score =  153 bits (386), Expect = 6e-37
 Identities = 91/236 (38%), Positives = 128/236 (54%), Gaps = 6/236 (2%)

Query: 207 YLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYE 266
           +LN  GQ+    +LR  I+ GG++ S+R  VW +LL  Y    T  ER     +K +EY 
Sbjct: 404 HLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYS 463

Query: 267 QLKSEWAQRANPEDLEFIRS---TVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAV 323
           +++ +       E   F R+   TV KDV+RTDR + ++ G ED P++ ++  +L  YAV
Sbjct: 464 EIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRG-EDNPNVESMRRILLNYAV 522

Query: 324 THPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLL 383
            +P V Y QGMSDL +PILA +  E   F CF G+M+       P    M  +  +L+ L
Sbjct: 523 YNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLREL 582

Query: 384 LRHADPDFYQYLQEAGADDL--FFCYRWLLLELKREFAFDDALRMLEVTWSSLPPD 437
           LR     FYQ+L   G D L   FC+RWLLL  KREF   +ALR+ E  W+    D
Sbjct: 583 LRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTD 638



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 17/54 (31%), Positives = 31/54 (57%)

Query: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARALFADY 670
           F LF+C+AI+  + D ++   L  +++ +HF  L    +   VLR+AR+L   +
Sbjct: 640 FHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQF 693


>gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo
           sapiens]
          Length = 1006

 Score =  110 bits (276), Expect = 3e-24
 Identities = 55/145 (37%), Positives = 88/145 (60%), Gaps = 6/145 (4%)

Query: 290 KDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEG 349
           KDV R DR + Y+  P    +L  L D++ +Y   H  V Y QGM DL +P+L  +D++ 
Sbjct: 799 KDVQRCDRNYWYFTPP----NLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQ 854

Query: 350 HAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAG-ADDLFFCYR 408
            A+ CF  +MKR++ NF P+G AM T FA+++ L++  D + ++ + + G     +FCYR
Sbjct: 855 LAYSCFSHLMKRMSQNF-PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 913

Query: 409 WLLLELKREFAFDDALRMLEVTWSS 433
           W LL+ KRE  ++D   + EV W++
Sbjct: 914 WFLLDFKRELLYEDVFAVWEVIWAA 938



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 19/54 (35%), Positives = 32/54 (59%)

Query: 219 ELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEW 272
           EL  ++Y+GG+E  +RK VW +LL  Y  G++ +E        +  Y+Q+ +EW
Sbjct: 557 ELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEW 610



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 16/50 (32%), Positives = 28/50 (56%)

Query: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666
           F+LF+ LA++  +R+ I  N +D+ ++   F+     H    +LR AR L
Sbjct: 946 FVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDL 995


>gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo
           sapiens]
          Length = 1051

 Score =  110 bits (276), Expect = 3e-24
 Identities = 55/145 (37%), Positives = 88/145 (60%), Gaps = 6/145 (4%)

Query: 290 KDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEG 349
           KDV R DR + Y+  P    +L  L D++ +Y   H  V Y QGM DL +P+L  +D++ 
Sbjct: 844 KDVQRCDRNYWYFTPP----NLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQ 899

Query: 350 HAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAG-ADDLFFCYR 408
            A+ CF  +MKR++ NF P+G AM T FA+++ L++  D + ++ + + G     +FCYR
Sbjct: 900 LAYSCFSHLMKRMSQNF-PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 958

Query: 409 WLLLELKREFAFDDALRMLEVTWSS 433
           W LL+ KRE  ++D   + EV W++
Sbjct: 959 WFLLDFKRELLYEDVFAVWEVIWAA 983



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 19/54 (35%), Positives = 32/54 (59%)

Query: 219 ELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEW 272
           EL  ++Y+GG+E  +RK VW +LL  Y  G++ +E        +  Y+Q+ +EW
Sbjct: 602 ELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEW 655



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 16/50 (32%), Positives = 28/50 (56%)

Query: 617  FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666
            F+LF+ LA++  +R+ I  N +D+ ++   F+     H    +LR AR L
Sbjct: 991  FVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDL 1040


>gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo
           sapiens]
          Length = 1032

 Score =  107 bits (268), Expect = 3e-23
 Identities = 54/145 (37%), Positives = 85/145 (58%), Gaps = 6/145 (4%)

Query: 290 KDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEG 349
           KDV R DR + Y+       +L  L +++ +Y   H ++ Y QGM DL +P+L ++D E 
Sbjct: 825 KDVQRCDRNYWYFTPA----NLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEA 880

Query: 350 HAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAG-ADDLFFCYR 408
            AF CF  +MKR+  NF P G AM T FA+++ L++  D + ++ + + G     +FCYR
Sbjct: 881 LAFSCFTELMKRMNQNF-PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 939

Query: 409 WLLLELKREFAFDDALRMLEVTWSS 433
           W LL+ KRE  +DD   + E  W++
Sbjct: 940 WFLLDFKRELVYDDVFLVWETIWAA 964



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 22/50 (44%), Positives = 30/50 (60%), Gaps = 1/50 (2%)

Query: 207 YLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMD 256
           YL+        E LRL IY+GG++P +RK VW +LL  Y  G+T  ER +
Sbjct: 542 YLHDSTSYEEQELLRL-IYYGGIQPEIRKAVWPFLLGHYQFGMTETERKE 590



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 16/50 (32%), Positives = 33/50 (66%)

Query: 617  FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666
            ++LF+ LA++  +RD I+ N +D+ ++   F+ +  +H+  +VL+ AR L
Sbjct: 972  YVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDL 1021


>gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo
            sapiens]
          Length = 1093

 Score =  107 bits (268), Expect = 3e-23
 Identities = 54/145 (37%), Positives = 85/145 (58%), Gaps = 6/145 (4%)

Query: 290  KDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEG 349
            KDV R DR + Y+       +L  L +++ +Y   H ++ Y QGM DL +P+L ++D E 
Sbjct: 886  KDVQRCDRNYWYFTPA----NLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEA 941

Query: 350  HAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAG-ADDLFFCYR 408
             AF CF  +MKR+  NF P G AM T FA+++ L++  D + ++ + + G     +FCYR
Sbjct: 942  LAFSCFTELMKRMNQNF-PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 1000

Query: 409  WLLLELKREFAFDDALRMLEVTWSS 433
            W LL+ KRE  +DD   + E  W++
Sbjct: 1001 WFLLDFKRELVYDDVFLVWETIWAA 1025



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 26/66 (39%), Positives = 37/66 (56%), Gaps = 1/66 (1%)

Query: 207 YLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYE 266
           YL+        E LRL IY+GG++P +RK VW +LL  Y  G+T  ER +  ++    Y 
Sbjct: 542 YLHDSTSYEEQELLRL-IYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYA 600

Query: 267 QLKSEW 272
           Q  +EW
Sbjct: 601 QTMAEW 606



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 16/50 (32%), Positives = 33/50 (66%)

Query: 617  FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666
            ++LF+ LA++  +RD I+ N +D+ ++   F+ +  +H+  +VL+ AR L
Sbjct: 1033 YVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDL 1082


>gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sapiens]
          Length = 1087

 Score =  107 bits (268), Expect = 3e-23
 Identities = 54/145 (37%), Positives = 85/145 (58%), Gaps = 6/145 (4%)

Query: 290  KDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEG 349
            KDV R DR + Y+       +L  L +++ +Y   H ++ Y QGM DL +P+L ++D E 
Sbjct: 880  KDVQRCDRNYWYFTPA----NLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEA 935

Query: 350  HAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAG-ADDLFFCYR 408
             AF CF  +MKR+  NF P G AM T FA+++ L++  D + ++ + + G     +FCYR
Sbjct: 936  LAFSCFTELMKRMNQNF-PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 994

Query: 409  WLLLELKREFAFDDALRMLEVTWSS 433
            W LL+ KRE  +DD   + E  W++
Sbjct: 995  WFLLDFKRELVYDDVFLVWETIWAA 1019



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 22/50 (44%), Positives = 30/50 (60%), Gaps = 1/50 (2%)

Query: 207 YLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMD 256
           YL+        E LRL IY+GG++P +RK VW +LL  Y  G+T  ER +
Sbjct: 597 YLHDSTSYEEQELLRL-IYYGGIQPEIRKAVWPFLLGHYQFGMTETERKE 645



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 16/50 (32%), Positives = 33/50 (66%)

Query: 617  FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666
            ++LF+ LA++  +RD I+ N +D+ ++   F+ +  +H+  +VL+ AR L
Sbjct: 1027 YVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDL 1076


>gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sapiens]
          Length = 1148

 Score =  107 bits (268), Expect = 3e-23
 Identities = 54/145 (37%), Positives = 85/145 (58%), Gaps = 6/145 (4%)

Query: 290  KDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEG 349
            KDV R DR + Y+       +L  L +++ +Y   H ++ Y QGM DL +P+L ++D E 
Sbjct: 941  KDVQRCDRNYWYFTPA----NLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEA 996

Query: 350  HAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAG-ADDLFFCYR 408
             AF CF  +MKR+  NF P G AM T FA+++ L++  D + ++ + + G     +FCYR
Sbjct: 997  LAFSCFTELMKRMNQNF-PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 1055

Query: 409  WLLLELKREFAFDDALRMLEVTWSS 433
            W LL+ KRE  +DD   + E  W++
Sbjct: 1056 WFLLDFKRELVYDDVFLVWETIWAA 1080



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 26/66 (39%), Positives = 37/66 (56%), Gaps = 1/66 (1%)

Query: 207 YLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYE 266
           YL+        E LRL IY+GG++P +RK VW +LL  Y  G+T  ER +  ++    Y 
Sbjct: 597 YLHDSTSYEEQELLRL-IYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYA 655

Query: 267 QLKSEW 272
           Q  +EW
Sbjct: 656 QTMAEW 661



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 16/50 (32%), Positives = 33/50 (66%)

Query: 617  FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666
            ++LF+ LA++  +RD I+ N +D+ ++   F+ +  +H+  +VL+ AR L
Sbjct: 1088 YVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDL 1137


>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
          Length = 1298

 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 50/204 (24%), Positives = 86/204 (42%), Gaps = 16/204 (7%)

Query: 228  GVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRST 287
            GV  S R  +W++L             + Y  R     +Q   + + +   + L   +  
Sbjct: 918  GVPKSRRGEIWQFLA------------LQYRLRHRLPNKQQPPDISYKELLKQLTAQQHA 965

Query: 288  VLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDH 347
            +L D+ RT   HPY++  + GP   +L +LL  Y++   +V YCQG+S +A  +L  M  
Sbjct: 966  ILVDLGRTFPTHPYFS-VQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSE 1024

Query: 348  EGHAFVCFCGIMKRLA--ANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFF 405
            E  AF     +M  L     + PD  ++  +   L  LL     D Y +L+E       +
Sbjct: 1025 E-QAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLY 1083

Query: 406  CYRWLLLELKREFAFDDALRMLEV 429
               W L     +F+     R+ ++
Sbjct: 1084 AAPWFLTLFASQFSLGFVARVFDI 1107


>gi|190014603 TBC1 domain family, member 13 [Homo sapiens]
          Length = 400

 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 42/142 (29%), Positives = 62/142 (43%), Gaps = 18/142 (12%)

Query: 310 HLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVM---------DH-EGHAFVCFCGIM 359
           H   +  +L  YA  +P ++Y QGM+++  P+             +H E   F CF  +M
Sbjct: 207 HWEVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNLM 266

Query: 360 KRLAANFHP---DGRAMAT-KFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELK 415
             +  NF     D +   T K   +   L+  D + Y  LQE      FF +RWL L L 
Sbjct: 267 AEIRDNFIKSLDDSQCGITYKMEKVYSTLKDKDVELYLKLQEQNIKPQFFAFRWLTLLLS 326

Query: 416 REFAFDDALRMLEVTWSSLPPD 437
           +EF   D +R+    W SL  D
Sbjct: 327 QEFLLPDVIRI----WDSLFAD 344


>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
           [Homo sapiens]
          Length = 1168

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 51/237 (21%), Positives = 97/237 (40%), Gaps = 30/237 (12%)

Query: 221 RLRIYHGGVEPSLRKV--VWRYLLNV----------------YPDGLTGRERMDYMKRKS 262
           RL++ +  + P L++V  VW  +L+                    G+    R +  K  +
Sbjct: 755 RLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLA 814

Query: 263 REYEQLKSEWAQRANPEDLEFI---------RSTVLKDVLRTDRAHPYYAGPEDGPHLRA 313
            ++  LK ++  +  P+D+ +          +  +L D+ RT   HPY++       L +
Sbjct: 815 EQFH-LKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQL-S 872

Query: 314 LHDLLTTYAVTHPQVSYCQGMSDLASPILAVM-DHEGHAFVCFCGIMKRLAANFHPDGRA 372
           L+++L  Y++   +V YCQG+S +A  +L  M + E    + F      L   + PD   
Sbjct: 873 LYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMII 932

Query: 373 MATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEV 429
           +  +   L  LL     D Y +L+E       +   W L     +F      R+ ++
Sbjct: 933 LQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDM 989


>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
          Length = 1069

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 53/205 (25%), Positives = 86/205 (41%), Gaps = 25/205 (12%)

Query: 216 RPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQR 275
           RP++L   +   GV  +LR  VW+ L         G    D++  K R           +
Sbjct: 555 RPKQLS-SLVRNGVPEALRGEVWQLL--------AGCHNNDHLVEKYRIL-------ITK 598

Query: 276 ANPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMS 335
            +P+D     S + +D+ RT  AH Y+     G    +L+ +   Y+V   ++ YCQG S
Sbjct: 599 ESPQD-----SAITRDINRTFPAHDYFKDT-GGDGQDSLYKICKAYSVYDEEIGYCQGQS 652

Query: 336 DLASPILAVMDHEGHAFVCFCGIM--KRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQ 393
            LA+ +L  M  E  AF     IM    L   F  +   +  KF  L+ L++   PD Y 
Sbjct: 653 FLAAVLLLHMPEE-QAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYN 711

Query: 394 YLQEAGADDLFFCYRWLLLELKREF 418
           +  +   +   +  +W L     +F
Sbjct: 712 HFLDISLEAHMYASQWFLTLFTAKF 736


>gi|23503283 TBC1 domain family, member 21 [Homo sapiens]
          Length = 336

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 52/248 (20%), Positives = 105/248 (42%), Gaps = 13/248 (5%)

Query: 196 KPPLSDAEFHTYLNHEGQLSRPEE-LRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRER 254
           KPP+   E+ ++ +  G L++  + + + I   G+ P +R   W++L   +    +  ER
Sbjct: 24  KPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHPFVRTEAWKFLTGYFSWQSSQDER 83

Query: 255 MDYMKRKSREYEQLKSEWAQRANP------EDLEFIRSTVLKDVLRTDRAHPYYAGPEDG 308
           +     + + Y+ L  +  ++  P       +    R+ + +D+ +     P      D 
Sbjct: 84  LTVDSMRRKNYKAL-CQMYEKIQPLLENLHRNFTETRNNIARDIQKIYDKDPLGNVLIDK 142

Query: 309 PHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHP 368
             L  +  LL +Y V + Q  Y QG  ++      +++H+   F  F   +++   +   
Sbjct: 143 KRLEKI--LLLSY-VCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLFQFFLQK-TEHSCV 198

Query: 369 DGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREF-AFDDALRML 427
               +A     L  L+   DP F ++L+  GA  +   + W     +R F +FDD  R+ 
Sbjct: 199 INIGVAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSFDDVWRLW 258

Query: 428 EVTWSSLP 435
           EV  +  P
Sbjct: 259 EVLLTGKP 266


>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
          Length = 808

 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 55/225 (24%), Positives = 95/225 (42%), Gaps = 22/225 (9%)

Query: 207 YLNHEGQLSRP-EELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREY 265
           + N +  LSR  ++++LR    G+  SLR   W+YL N        +E ++    K  E 
Sbjct: 339 FSNWDKWLSRRFQKVKLRC-RKGIPSSLRAKAWQYLSN-------SKELLEQNPGKFEEL 390

Query: 266 EQLKSEWAQRANPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTH 325
           E+   +      P+ L+ I     KD+ R    H  +A    G   + L+ +L  Y +  
Sbjct: 391 ERAPGD------PKWLDVIE----KDLHRQFPFHEMFAA-RGGHGQQDLYRILKAYTIYR 439

Query: 326 PQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDG-RAMATKFAHLKLLL 384
           P   YCQ  + +A+ +L  M  E  AF C   I  +    ++  G  A+         LL
Sbjct: 440 PDEGYCQAQAPVAAVLLMHMPAE-QAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALL 498

Query: 385 RHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEV 429
           R A P  +++L+    D + +   W +    R   +   LR+ ++
Sbjct: 499 RRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDM 543


>gi|40068063 TBC1 domain family, member 22B [Homo sapiens]
          Length = 505

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 51/231 (22%), Positives = 89/231 (38%), Gaps = 29/231 (12%)

Query: 228 GVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRST 287
           GV   +R + WR LL+ Y    T R ++  ++RK  EY     ++    N E  +     
Sbjct: 210 GVPREVRPITWR-LLSGYLPANTERRKLT-LQRKREEYFGFIEQYYDSRNEEHHQDTYRQ 267

Query: 288 VLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVM-- 345
           +  D+ RT+   P +  P           +L  +A+ HP   Y QG++DL +P   V   
Sbjct: 268 IHIDIPRTNPLIPLFQQPLVQ---EIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLS 324

Query: 346 ---------------------DHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLL 384
                                  E  +F C   ++  +  N+      +  K   L+ L+
Sbjct: 325 EYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELV 384

Query: 385 RHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLP 435
              D   + + +    + L F +RW+   L RE      +R+ + T+ S P
Sbjct: 385 SRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWD-TYQSEP 434


>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
          Length = 775

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 45/211 (21%), Positives = 85/211 (40%), Gaps = 16/211 (7%)

Query: 228 GVEPSLRKVVWRYL----LNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEF 283
           G+ PS+R  VW       LN+ P      E  +    +++E  +  SE +   + E +  
Sbjct: 484 GLPPSVRGKVWSLAVGNELNITP------ELYEIFLSRAKERWKSFSETSSENDTEGVSV 537

Query: 284 IRSTVLKDVLRTDRAHPY---YAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP 340
                  ++++ D +  +   Y   + GP+   LH +L  Y    P V Y QGMS +A+ 
Sbjct: 538 ADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAV 597

Query: 341 ILAVMDHEGHAFVCFCGIMKR--LAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEA 398
           ++  ++ E  AF+ F  ++ +    A F  D   M   FA  ++         + + +  
Sbjct: 598 LILNLE-EADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSY 656

Query: 399 GADDLFFCYRWLLLELKREFAFDDALRMLEV 429
                 +   W+     +    D A R+ +V
Sbjct: 657 SLTPDIYLIDWIFTLYSKSLPLDLACRVWDV 687


>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
           sapiens]
          Length = 815

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 50/212 (23%), Positives = 85/212 (40%), Gaps = 27/212 (12%)

Query: 210 HEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPD-GLTGRERMDYMKRKSREYEQL 268
           H    +RP+ L   +   GV  +LR  VW+ L   + +  +  R R+   K  ++E    
Sbjct: 521 HSNLGARPKGLSTLV-KSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITKDSAQE---- 575

Query: 269 KSEWAQRANPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQV 328
                            S + +D+ RT  AH Y+     G    +L+ +   Y+V    +
Sbjct: 576 -----------------SVITRDIHRTFPAHDYFKDT-GGDGQESLYKICKAYSVYDEDI 617

Query: 329 SYCQGMSDLASPILAVMDHEGHAFVCFCGIM--KRLAANFHPDGRAMATKFAHLKLLLRH 386
            YCQG S LA+ +L  M  E  AF     IM    L   +  +   +  KF  L+ L++ 
Sbjct: 618 GYCQGQSFLAAVLLLHMPEE-QAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQE 676

Query: 387 ADPDFYQYLQEAGADDLFFCYRWLLLELKREF 418
             PD + +  +   +   +  +W L     +F
Sbjct: 677 QLPDLHSHFSDLNLEAHMYASQWFLTLFTAKF 708


>gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]
          Length = 413

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 50/209 (23%), Positives = 83/209 (39%), Gaps = 10/209 (4%)

Query: 228 GVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFI--- 284
           G+ PS+R  VW   L +  +     E  D    +++E  +  S        ED  F    
Sbjct: 121 GIPPSVRGKVWS--LAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAAD 178

Query: 285 RSTVLKDV-LRTDRAHPYYA-GPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPIL 342
           R   L+ + L   R  P      + GP+   LH +L  Y    P V Y QGMS +A+ ++
Sbjct: 179 REASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLI 238

Query: 343 AVMDHEGHAFVCFCGIMKR--LAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA 400
             +D    AF+ F  ++ +    A F  D   M T FA  ++      P  + + ++   
Sbjct: 239 LNLD-TADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNL 297

Query: 401 DDLFFCYRWLLLELKREFAFDDALRMLEV 429
               +   W+     +    D A R+ +V
Sbjct: 298 TPDIYLIDWIFTLYSKSLPLDLACRIWDV 326


>gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]
          Length = 693

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 50/209 (23%), Positives = 83/209 (39%), Gaps = 10/209 (4%)

Query: 228 GVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFI--- 284
           G+ PS+R  VW   L +  +     E  D    +++E  +  S        ED  F    
Sbjct: 401 GIPPSVRGKVWS--LAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAAD 458

Query: 285 RSTVLKDV-LRTDRAHPYYA-GPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPIL 342
           R   L+ + L   R  P      + GP+   LH +L  Y    P V Y QGMS +A+ ++
Sbjct: 459 REASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLI 518

Query: 343 AVMDHEGHAFVCFCGIMKR--LAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA 400
             +D    AF+ F  ++ +    A F  D   M T FA  ++      P  + + ++   
Sbjct: 519 LNLD-TADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNL 577

Query: 401 DDLFFCYRWLLLELKREFAFDDALRMLEV 429
               +   W+     +    D A R+ +V
Sbjct: 578 TPDIYLIDWIFTLYSKSLPLDLACRIWDV 606


>gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]
          Length = 693

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 50/209 (23%), Positives = 83/209 (39%), Gaps = 10/209 (4%)

Query: 228 GVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFI--- 284
           G+ PS+R  VW   L +  +     E  D    +++E  +  S        ED  F    
Sbjct: 401 GIPPSVRGKVWS--LAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAAD 458

Query: 285 RSTVLKDV-LRTDRAHPYYA-GPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPIL 342
           R   L+ + L   R  P      + GP+   LH +L  Y    P V Y QGMS +A+ ++
Sbjct: 459 REASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLI 518

Query: 343 AVMDHEGHAFVCFCGIMKR--LAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA 400
             +D    AF+ F  ++ +    A F  D   M T FA  ++      P  + + ++   
Sbjct: 519 LNLD-TADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNL 577

Query: 401 DDLFFCYRWLLLELKREFAFDDALRMLEV 429
               +   W+     +    D A R+ +V
Sbjct: 578 TPDIYLIDWIFTLYSKSLPLDLACRIWDV 606


>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
          Length = 446

 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 37/141 (26%), Positives = 59/141 (41%), Gaps = 3/141 (2%)

Query: 287 TVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMD 346
           T+ +D+ R    H  +  P+ G   + L  +L  Y +  P+  YCQ    +A+ +L  + 
Sbjct: 134 TIGRDLHRQFPLHEMFVSPQ-GHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLP 192

Query: 347 HEGHAFVCFCGIMK-RLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFF 405
            E  AF C   I +  L   + P   A+         LLR   P  +++LQ+ G   L +
Sbjct: 193 PE-EAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLY 251

Query: 406 CYRWLLLELKREFAFDDALRM 426
              W L    R   F   LR+
Sbjct: 252 LPEWFLCLFARSLPFPTVLRV 272


>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sapiens]
          Length = 2161

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 57/216 (26%), Positives = 76/216 (35%), Gaps = 40/216 (18%)

Query: 435  PPDPPEHEV--ELVGPPSQVADAGFGGHRGW----------PVRQRHMLRPAGGGGSTFE 482
            PP PPE E       PP ++A       RGW               H     GGGGS+  
Sbjct: 1020 PPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQG 1079

Query: 483  DAVDHL------------ATASQGPGGGGRLLRQASLDGLQQLRDNMG---SRRDPLVQL 527
             A+ +               A  G G  G L++Q  ++G  Q    +    S   P    
Sbjct: 1080 PALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGGGLPPAPSPTSPASPQ 1139

Query: 528  PHPAALISSKSLSEPL----LNSPDPLLSSFSHPDSPSSSSPPSTQEASPTGDMAVGSPL 583
            P PA    S+  S P+    + +P    S  S   S + + PP+  E  PTG    G   
Sbjct: 1140 PPPAVAAPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPE--PTGGGGGG--- 1194

Query: 584  MQEVGSPKDPGKSLPPVPPMGLPPPQEFGRGNPFML 619
                GS   P  ++ PVPP   P P       P  L
Sbjct: 1195 ----GSSPSPAPAMSPVPPSPSPVPTPASPSGPATL 1226



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 27/86 (31%), Positives = 34/86 (39%), Gaps = 27/86 (31%)

Query: 523  PLVQLPHPAALISSKS----LSEPLLNSPDPL--LSSFSHPDSPSSSSPPSTQEASPTGD 576
            PL+ LP PA  +  +       EPL   P PL   +SF  P+SP +  PP     +P   
Sbjct: 1543 PLLVLPPPAPSVDVEDGEFLFVEPL---PPPLEFSNSFEKPESPLTPGPPHPLPDTPA-- 1597

Query: 577  MAVGSPLMQEVGSPKDPGKSLPPVPP 602
                            P   LPPVPP
Sbjct: 1598 ----------------PATPLPPVPP 1607



 Score = 29.6 bits (65), Expect = 9.7
 Identities = 30/116 (25%), Positives = 42/116 (36%), Gaps = 23/116 (19%)

Query: 495 PGGGGRLLRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLSEPLLNSPDPLLSSF 554
           P G G +LRQ S+   +  R  +            P A+  S+SLS P      P     
Sbjct: 879 PPGPGLMLRQKSIGAAEDDRPYLA-----------PPAMKFSRSLSVPGSEDIPP----- 922

Query: 555 SHPDSPSSSSPPSTQEASPTGDMAVGSPLMQEVGSPKDPGKS--LPPVPPMGLPPP 608
                P ++SPP    ++P    + G       G P +PG    LP   P     P
Sbjct: 923 -----PPTTSPPEPPYSTPPVPSSSGRLTPSPRGGPFNPGSGGPLPASSPASFDGP 973


>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
          Length = 508

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 47/213 (22%), Positives = 88/213 (41%), Gaps = 21/213 (9%)

Query: 218 EELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRAN 277
           +++RLR   G + PSLR   W+YL         G+ ++     K  E +          +
Sbjct: 102 KKIRLRCQKG-IPPSLRGRAWQYLSG-------GKVKLQQNPGKFDELDM---------S 144

Query: 278 PEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDL 337
           P D +++   + +D+ R    H  +     G   + L  +L  Y +  P+  YCQ  + +
Sbjct: 145 PGDPKWL-DVIERDLHRQFPFHEMFVS-RGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPI 202

Query: 338 ASPILAVMDHEGHAFVCFCGIMKRLAANFHPDG-RAMATKFAHLKLLLRHADPDFYQYLQ 396
           A+ +L  M  E  AF C   I ++    ++ +   A+      L  LL+   P  +++L 
Sbjct: 203 AAVLLMHMPAE-QAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLS 261

Query: 397 EAGADDLFFCYRWLLLELKREFAFDDALRMLEV 429
               D L +   W +    R   +   LR+ ++
Sbjct: 262 RQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDM 294


>gi|229577000 ecotropic viral integration site 5-like isoform 1
           [Homo sapiens]
          Length = 805

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 46/216 (21%), Positives = 83/216 (38%), Gaps = 25/216 (11%)

Query: 216 RPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQR 275
           R E+L   +   G+    R +VW+ L +              M  K++  E LK      
Sbjct: 103 RKEKLLKELIRKGIPHHFRAIVWQLLCSATD-----------MPVKNQYSELLKM----- 146

Query: 276 ANPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMS 335
           ++P         + +D+ RT   H ++ G +D      L +++  Y++   +V YCQG +
Sbjct: 147 SSP-----CEKLIRRDIARTYPEHEFFKG-QDSLGQEVLFNVMKAYSLVDREVGYCQGSA 200

Query: 336 DLASPILAVMDHEGHAFVCFCGIMK--RLAANFHPDGRAMATKFAHLKLLLRHADPDFYQ 393
            +   +L  M  E  AF  F  +M+  RL   F P    +       + +L+   PD   
Sbjct: 201 FIVGLLLMQMPEE-EAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNT 259

Query: 394 YLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEV 429
           + +        +   W L      F    A R+ ++
Sbjct: 260 HFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDI 295


>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
           sapiens]
          Length = 794

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 46/216 (21%), Positives = 83/216 (38%), Gaps = 25/216 (11%)

Query: 216 RPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQR 275
           R E+L   +   G+    R +VW+ L +              M  K++  E LK      
Sbjct: 103 RKEKLLKELIRKGIPHHFRAIVWQLLCSATD-----------MPVKNQYSELLKM----- 146

Query: 276 ANPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMS 335
           ++P         + +D+ RT   H ++ G +D      L +++  Y++   +V YCQG +
Sbjct: 147 SSP-----CEKLIRRDIARTYPEHEFFKG-QDSLGQEVLFNVMKAYSLVDREVGYCQGSA 200

Query: 336 DLASPILAVMDHEGHAFVCFCGIMK--RLAANFHPDGRAMATKFAHLKLLLRHADPDFYQ 393
            +   +L  M  E  AF  F  +M+  RL   F P    +       + +L+   PD   
Sbjct: 201 FIVGLLLMQMPEE-EAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNT 259

Query: 394 YLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEV 429
           + +        +   W L      F    A R+ ++
Sbjct: 260 HFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDI 295


>gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo
           sapiens]
          Length = 761

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 47/171 (27%), Positives = 82/171 (47%), Gaps = 17/171 (9%)

Query: 228 GVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRST 287
           G+    R+ VW  L + Y   +     +D+ K        ++  + +R+NP+D + +   
Sbjct: 86  GIPKEWRRKVWLTLADHYLHSIA----IDWDKT-------MRFTFNERSNPDD-DSMGIQ 133

Query: 288 VLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMD- 346
           ++KD+ RT  +   Y G E       L  +L  YA  +  V YCQG + LA+ IL VM+ 
Sbjct: 134 IVKDLHRTGCSS--YCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEG 191

Query: 347 HEGHAFVCFCGIMKRL--AANFHPDGRAMATKFAHLKLLLRHADPDFYQYL 395
           +EG A      ++ ++   + F  + RA++   A  + LLR   P+  Q+L
Sbjct: 192 NEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHL 242


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.136    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,053,197
Number of Sequences: 37866
Number of extensions: 1679629
Number of successful extensions: 10535
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 97
Number of HSP's successfully gapped in prelim test: 391
Number of HSP's that attempted gapping in prelim test: 8807
Number of HSP's gapped (non-prelim): 1822
length of query: 688
length of database: 18,247,518
effective HSP length: 109
effective length of query: 579
effective length of database: 14,120,124
effective search space: 8175551796
effective search space used: 8175551796
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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