Guide to the Human Genome
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Search of human proteins with 5453930

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5453930 DNA directed RNA polymerase II polypeptide I [Homo
sapiens]
         (125 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5453930 DNA directed RNA polymerase II polypeptide I [Homo sa...   276   2e-75
gi|7706499 DNA directed RNA polymerase III polypeptide K [Homo s...    54   2e-08
gi|25777707 zinc ribbon domain containing 1 [Homo sapiens]             33   0.043
gi|7657709 zinc ribbon domain containing 1 [Homo sapiens]              33   0.043
gi|239749424 PREDICTED: hypothetical protein XP_002347041 [Homo ...    32   0.095
gi|5803191 transcription elongation factor A 1 isoform 1 [Homo s...    32   0.095
gi|45439355 transcription elongation factor A 1 isoform 2 [Homo ...    32   0.095
gi|38505156 transcription elongation factor A protein 2 isoform ...    31   0.21 
gi|4507385 transcription elongation factor A protein 2 isoform a...    31   0.21 
gi|41054864 regulating synaptic membrane exocytosis 1 [Homo sapi...    30   0.62 
gi|166197671 adaptor-related protein complex 4, beta 1 subunit [...    28   1.4  
gi|223005929 hypothetical protein LOC284071 [Homo sapiens]             28   2.3  
gi|21361146 zinc finger protein 76 (expressed in testis) [Homo s...    28   2.3  
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo...    27   4.0  
gi|239755976 PREDICTED: hypothetical protein [Homo sapiens]            27   4.0  
gi|27894361 nuclear receptor subfamily 4, group A, member 3 isof...    27   4.0  
gi|27894359 nuclear receptor subfamily 4, group A, member 3 isof...    27   4.0  
gi|27894357 nuclear receptor subfamily 4, group A, member 3 isof...    27   4.0  
gi|27894355 nuclear receptor subfamily 4, group A, member 3 isof...    27   4.0  
gi|5453838 Sjogren syndrome/scleroderma autoantigen 1 [Homo sapi...    27   4.0  
gi|102468717 mediator complex subunit 13 [Homo sapiens]                27   5.2  
gi|34485722 karyopherin alpha 3 [Homo sapiens]                         27   5.2  
gi|148612859 coiled-coil-helix-coiled-coil-helix domain containi...    27   5.2  
gi|4502349 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 3 ...    26   6.8  
gi|4504901 karyopherin alpha 4 [Homo sapiens]                          26   6.8  
gi|148664201 cytoskeleton associated protein 2 isoform 2 [Homo s...    26   6.8  
gi|148664244 cytoskeleton associated protein 2 isoform 1 [Homo s...    26   6.8  

>gi|5453930 DNA directed RNA polymerase II polypeptide I [Homo
           sapiens]
          Length = 125

 Score =  276 bits (707), Expect = 2e-75
 Identities = 125/125 (100%), Positives = 125/125 (100%)

Query: 1   MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH 60
           MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
Sbjct: 1   MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH 60

Query: 61  EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG 120
           EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
Sbjct: 61  EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG 120

Query: 121 HRWTE 125
           HRWTE
Sbjct: 121 HRWTE 125


>gi|7706499 DNA directed RNA polymerase III polypeptide K [Homo
           sapiens]
          Length = 108

 Score = 54.3 bits (129), Expect = 2e-08
 Identities = 30/110 (27%), Positives = 47/110 (42%), Gaps = 5/110 (4%)

Query: 16  FCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIADVSQD 75
           FC  C N L  +E +  R   +AC  C Y           N+   ++ E+  ++   +  
Sbjct: 4   FCPGCGNGLIVEEGQ--RCHRFACNTCPYVHNITRKV--TNRKYPKLKEVDDVLGGAAAW 59

Query: 76  PTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHRWTE 125
             +  T +  C KC H  A F Q  +  A++ M  +Y C    CGHRW +
Sbjct: 60  ENVDSTAES-CPKCEHPRAYFMQLQTRSADEPMTTFYKCCNAQCGHRWRD 108


>gi|25777707 zinc ribbon domain containing 1 [Homo sapiens]
          Length = 126

 Score = 33.5 bits (75), Expect = 0.043
 Identities = 17/100 (17%), Positives = 41/100 (41%), Gaps = 2/100 (2%)

Query: 16  FCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIADVSQD 75
           FC +C ++L P    ++ +    C      ++ +   +  + + H++     +  +   +
Sbjct: 19  FCSDCGSVL-PLPGAQDTVTCIRCGFNINVRDFEGKVVKTSVVFHQLGTAMPMSVEEGPE 77

Query: 76  PTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCT 115
              P   D  C +CGH+   +       A++   ++Y CT
Sbjct: 78  CQGP-VVDRRCPRCGHEGMAYHTRQMRSADEGQTVFYTCT 116


>gi|7657709 zinc ribbon domain containing 1 [Homo sapiens]
          Length = 126

 Score = 33.5 bits (75), Expect = 0.043
 Identities = 17/100 (17%), Positives = 41/100 (41%), Gaps = 2/100 (2%)

Query: 16  FCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIADVSQD 75
           FC +C ++L P    ++ +    C      ++ +   +  + + H++     +  +   +
Sbjct: 19  FCSDCGSVL-PLPGAQDTVTCIRCGFNINVRDFEGKVVKTSVVFHQLGTAMPMSVEEGPE 77

Query: 76  PTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCT 115
              P   D  C +CGH+   +       A++   ++Y CT
Sbjct: 78  CQGP-VVDRRCPRCGHEGMAYHTRQMRSADEGQTVFYTCT 116


>gi|239749424 PREDICTED: hypothetical protein XP_002347041 [Homo
           sapiens]
          Length = 287

 Score = 32.3 bits (72), Expect = 0.095
 Identities = 14/44 (31%), Positives = 22/44 (50%), Gaps = 2/44 (4%)

Query: 80  RTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHRW 123
           +T+   C KC  K   + Q  +  A++ M  + VC    CG+RW
Sbjct: 243 QTDLFTCGKCKKKNCTYTQVQTRSADEPMTTFVVCN--ECGNRW 284


>gi|5803191 transcription elongation factor A 1 isoform 1 [Homo
           sapiens]
          Length = 301

 Score = 32.3 bits (72), Expect = 0.095
 Identities = 14/44 (31%), Positives = 22/44 (50%), Gaps = 2/44 (4%)

Query: 80  RTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHRW 123
           +T+   C KC  K   + Q  +  A++ M  + VC    CG+RW
Sbjct: 257 QTDLFTCGKCKKKNCTYTQVQTRSADEPMTTFVVCN--ECGNRW 298


>gi|45439355 transcription elongation factor A 1 isoform 2 [Homo
           sapiens]
          Length = 280

 Score = 32.3 bits (72), Expect = 0.095
 Identities = 14/44 (31%), Positives = 22/44 (50%), Gaps = 2/44 (4%)

Query: 80  RTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHRW 123
           +T+   C KC  K   + Q  +  A++ M  + VC    CG+RW
Sbjct: 236 QTDLFTCGKCKKKNCTYTQVQTRSADEPMTTFVVCN--ECGNRW 277


>gi|38505156 transcription elongation factor A protein 2 isoform b
           [Homo sapiens]
          Length = 272

 Score = 31.2 bits (69), Expect = 0.21
 Identities = 13/44 (29%), Positives = 22/44 (50%), Gaps = 2/44 (4%)

Query: 80  RTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHRW 123
           +T+   C KC  K   + Q  +  +++ M  + VC    CG+RW
Sbjct: 228 QTDLFTCGKCRKKNCTYTQVQTRSSDEPMTTFVVCN--ECGNRW 269


>gi|4507385 transcription elongation factor A protein 2 isoform a
           [Homo sapiens]
          Length = 299

 Score = 31.2 bits (69), Expect = 0.21
 Identities = 13/44 (29%), Positives = 22/44 (50%), Gaps = 2/44 (4%)

Query: 80  RTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHRW 123
           +T+   C KC  K   + Q  +  +++ M  + VC    CG+RW
Sbjct: 255 QTDLFTCGKCRKKNCTYTQVQTRSSDEPMTTFVVCN--ECGNRW 296


>gi|41054864 regulating synaptic membrane exocytosis 1 [Homo
           sapiens]
          Length = 1692

 Score = 29.6 bits (65), Expect = 0.62
 Identities = 9/33 (27%), Positives = 19/33 (57%)

Query: 15  RFCQECNNMLYPKEDKENRILLYACRNCDYQQE 47
           +FC  C   +  + + E++++++ C  C  QQE
Sbjct: 138 KFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQE 170


>gi|166197671 adaptor-related protein complex 4, beta 1 subunit
           [Homo sapiens]
          Length = 739

 Score = 28.5 bits (62), Expect = 1.4
 Identities = 18/65 (27%), Positives = 25/65 (38%), Gaps = 7/65 (10%)

Query: 19  ECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIADVSQDPTL 78
           EC +ML        R+L Y           D    Y   +   +DE+ +I+     DPTL
Sbjct: 490 ECQDML-------GRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDPTL 542

Query: 79  PRTED 83
              ED
Sbjct: 543 GLLED 547


>gi|223005929 hypothetical protein LOC284071 [Homo sapiens]
          Length = 825

 Score = 27.7 bits (60), Expect = 2.3
 Identities = 28/116 (24%), Positives = 43/116 (37%), Gaps = 15/116 (12%)

Query: 15  RFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQI------ 68
           R+ +  +   YP+    N+  L  C N   Q     +       T E D  T++      
Sbjct: 318 RYNENVDYCRYPEYVHPNKAKLNKCSNFSVQDSKKLANGTPETPTVEADTYTKLFQVKPA 377

Query: 69  --------IADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTA 116
                   I D  Q+ T P+T  H  +K   KEAVF       +E  ++ +  C A
Sbjct: 378 NQKKMEETIPD-QQNFTFPKTTPHLTEKQFAKEAVFTADFGLTSEYGLKPHTACPA 432


>gi|21361146 zinc finger protein 76 (expressed in testis) [Homo
           sapiens]
          Length = 570

 Score = 27.7 bits (60), Expect = 2.3
 Identities = 10/14 (71%), Positives = 11/14 (78%)

Query: 112 YVCTAPHCGHRWTE 125
           YVCT P CG R+TE
Sbjct: 315 YVCTVPGCGKRFTE 328


>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
           sapiens]
          Length = 598

 Score = 26.9 bits (58), Expect = 4.0
 Identities = 11/42 (26%), Positives = 17/42 (40%)

Query: 13  GIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIY 54
           G+R C+ C         K  + +  A +NC   +   N C Y
Sbjct: 276 GVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQY 317


>gi|239755976 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 380

 Score = 26.9 bits (58), Expect = 4.0
 Identities = 16/61 (26%), Positives = 28/61 (45%), Gaps = 8/61 (13%)

Query: 4   DGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVD 63
           D  + PGF+G+R CQ        +  ++  +   AC  C      + SC +V +  ++ D
Sbjct: 102 DREFLPGFLGLRSCQRA------ESGRQGNMHWGAC--CLQPSVYEKSCQHVTEAVYQQD 153

Query: 64  E 64
           E
Sbjct: 154 E 154


>gi|27894361 nuclear receptor subfamily 4, group A, member 3 isoform
           b [Homo sapiens]
          Length = 637

 Score = 26.9 bits (58), Expect = 4.0
 Identities = 11/42 (26%), Positives = 17/42 (40%)

Query: 13  GIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIY 54
           G+R C+ C         K  + +  A +NC   +   N C Y
Sbjct: 316 GVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQY 357


>gi|27894359 nuclear receptor subfamily 4, group A, member 3 isoform
           c [Homo sapiens]
          Length = 443

 Score = 26.9 bits (58), Expect = 4.0
 Identities = 11/42 (26%), Positives = 17/42 (40%)

Query: 13  GIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIY 54
           G+R C+ C         K  + +  A +NC   +   N C Y
Sbjct: 305 GVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQY 346


>gi|27894357 nuclear receptor subfamily 4, group A, member 3 isoform
           a [Homo sapiens]
          Length = 626

 Score = 26.9 bits (58), Expect = 4.0
 Identities = 11/42 (26%), Positives = 17/42 (40%)

Query: 13  GIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIY 54
           G+R C+ C         K  + +  A +NC   +   N C Y
Sbjct: 305 GVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQY 346


>gi|27894355 nuclear receptor subfamily 4, group A, member 3 isoform
           a [Homo sapiens]
          Length = 626

 Score = 26.9 bits (58), Expect = 4.0
 Identities = 11/42 (26%), Positives = 17/42 (40%)

Query: 13  GIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIY 54
           G+R C+ C         K  + +  A +NC   +   N C Y
Sbjct: 305 GVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQY 346


>gi|5453838 Sjogren syndrome/scleroderma autoantigen 1 [Homo
           sapiens]
          Length = 199

 Score = 26.9 bits (58), Expect = 4.0
 Identities = 17/69 (24%), Positives = 28/69 (40%), Gaps = 4/69 (5%)

Query: 17  CQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIADVSQDP 76
           C +C  +L   +DK+ +I   AC+  D   + DN  +       +  E    +A  S+ P
Sbjct: 53  CADCGTILL--QDKQRKIYCVACQELDSDVDKDNPALNAQAALSQARE--HQLASASELP 108

Query: 77  TLPRTEDHP 85
              R    P
Sbjct: 109 LGSRPAPQP 117


>gi|102468717 mediator complex subunit 13 [Homo sapiens]
          Length = 2174

 Score = 26.6 bits (57), Expect = 5.2
 Identities = 18/83 (21%), Positives = 34/83 (40%), Gaps = 6/83 (7%)

Query: 4   DGTYEPGFVGIRFCQECNNMLYP-KEDKENRILLYACRNCDYQQEADNSCIYVNKITHEV 62
           D   EP      F +     L+P K+D++N     + R    + + ++    V  ++HE 
Sbjct: 688 DAEQEPKIDPYAFVEGDEEFLFPDKKDRQN-----SEREAGKKHKVEDGTSSVTVLSHEE 742

Query: 63  DELTQIIADVSQDPTLPRTEDHP 85
           D ++     + QD   P +   P
Sbjct: 743 DAMSLFSPSIKQDAPRPTSHARP 765


>gi|34485722 karyopherin alpha 3 [Homo sapiens]
          Length = 521

 Score = 26.6 bits (57), Expect = 5.2
 Identities = 16/46 (34%), Positives = 23/46 (50%), Gaps = 1/46 (2%)

Query: 55  VNKITHEVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSH 100
           V  I    DE TQ++ +       P    HP +K  +KEAV+F S+
Sbjct: 308 VGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKI-NKEAVWFLSN 352


>gi|148612859 coiled-coil-helix-coiled-coil-helix domain
          containing 4 isoform 1 [Homo sapiens]
          Length = 142

 Score = 26.6 bits (57), Expect = 5.2
 Identities = 11/32 (34%), Positives = 17/32 (53%)

Query: 45 QQEADNSCIYVNKITHEVDELTQIIADVSQDP 76
          +QE  +  I+V K  HE     +++AD   DP
Sbjct: 5  RQEGKDRIIFVTKEDHETPSSAELVADDPNDP 36


>gi|4502349 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 3
           [Homo sapiens]
          Length = 393

 Score = 26.2 bits (56), Expect = 6.8
 Identities = 26/96 (27%), Positives = 37/96 (38%), Gaps = 4/96 (4%)

Query: 28  EDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDEL-TQIIADVSQDPTLPRTEDHPC 86
           E+  +R  L       + Q+  NS  Y   +  E+  L T I AD+  DP  PR    P 
Sbjct: 298 EENPHRFDLLVRTQNSWTQDGMNSLTY-QLLARELGPLYTNITADIGTDPRGPRAPSGPR 356

Query: 87  QKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHR 122
              G  +A  F+    +     R   + TA H   R
Sbjct: 357 YPPGSSQA--FRQEMLQRRPPARPGPLSTANHTALR 390


>gi|4504901 karyopherin alpha 4 [Homo sapiens]
          Length = 521

 Score = 26.2 bits (56), Expect = 6.8
 Identities = 16/46 (34%), Positives = 23/46 (50%), Gaps = 1/46 (2%)

Query: 55  VNKITHEVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSH 100
           V  I    DE TQ++ +       P    HP +K  +KEAV+F S+
Sbjct: 308 VGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKI-NKEAVWFLSN 352


>gi|148664201 cytoskeleton associated protein 2 isoform 2 [Homo
           sapiens]
          Length = 683

 Score = 26.2 bits (56), Expect = 6.8
 Identities = 20/64 (31%), Positives = 27/64 (42%), Gaps = 9/64 (14%)

Query: 22  NMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIADVSQDPTLPRT 81
           NM  P E K N ++   C       E  NS + ++  TH+         D +Q P L  T
Sbjct: 83  NMKRPAESKNNTVVGKHCIPLKPSNELTNSTVVID--THKP-------KDSNQTPHLLLT 133

Query: 82  EDHP 85
           ED P
Sbjct: 134 EDDP 137


>gi|148664244 cytoskeleton associated protein 2 isoform 1 [Homo
           sapiens]
          Length = 682

 Score = 26.2 bits (56), Expect = 6.8
 Identities = 20/64 (31%), Positives = 27/64 (42%), Gaps = 9/64 (14%)

Query: 22  NMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIADVSQDPTLPRT 81
           NM  P E K N ++   C       E  NS + ++  TH+         D +Q P L  T
Sbjct: 82  NMKRPAESKNNTVVGKHCIPLKPSNELTNSTVVID--THKP-------KDSNQTPHLLLT 132

Query: 82  EDHP 85
           ED P
Sbjct: 133 EDDP 136


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.448 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,600,879
Number of Sequences: 37866
Number of extensions: 228887
Number of successful extensions: 540
Number of sequences better than 10.0: 27
Number of HSP's better than 10.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 523
Number of HSP's gapped (non-prelim): 30
length of query: 125
length of database: 18,247,518
effective HSP length: 90
effective length of query: 35
effective length of database: 14,839,578
effective search space: 519385230
effective search space used: 519385230
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 55 (25.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
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