Guide to the Human Genome
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Search of human proteins with 5453766

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5453766 NEL-like protein 2 isoform b precursor [Homo
sapiens]
         (816 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|223029476 NEL-like protein 2 isoform d [Homo sapiens]             1799   0.0  
gi|223029472 NEL-like protein 2 isoform b precursor [Homo sapiens]   1799   0.0  
gi|223029470 NEL-like protein 2 isoform a [Homo sapiens]             1799   0.0  
gi|5453766 NEL-like protein 2 isoform b precursor [Homo sapiens]     1799   0.0  
gi|223029474 NEL-like protein 2 isoform c [Homo sapiens]             1765   0.0  
gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens]           1047   0.0  
gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens]            929   0.0  
gi|66346695 fibrillin 2 precursor [Homo sapiens]                      166   6e-41
gi|24430141 fibrillin 1 precursor [Homo sapiens]                      157   4e-38
gi|56237021 fibrillin 3 precursor [Homo sapiens]                      156   6e-38
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]              155   1e-37
gi|134244285 Notch homolog 3 [Homo sapiens]                           154   2e-37
gi|24041035 notch 2 preproprotein [Homo sapiens]                      147   5e-35
gi|118572606 hemicentin 1 [Homo sapiens]                              147   5e-35
gi|148833508 notch1 preproprotein [Homo sapiens]                      146   9e-35
gi|40807489 egf-like module containing, mucin-like, hormone rece...   142   1e-33
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]              139   1e-32
gi|17978491 CD97 antigen isoform 1 precursor [Homo sapiens]           138   2e-32
gi|21704279 jagged 2 isoform b precursor [Homo sapiens]               136   9e-32
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]              135   2e-31
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]              135   2e-31
gi|34734066 fibulin 1 isoform D [Homo sapiens]                        135   2e-31
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]              135   2e-31
gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens]   135   2e-31
gi|4557679 jagged 1 precursor [Homo sapiens]                          134   3e-31
gi|46249414 latent transforming growth factor beta binding prote...   130   4e-30
gi|46249412 latent transforming growth factor beta binding prote...   130   4e-30
gi|110347437 latent transforming growth factor beta binding prot...   129   8e-30
gi|110347412 latent transforming growth factor beta binding prot...   129   8e-30
gi|110347431 latent transforming growth factor beta binding prot...   129   8e-30

>gi|223029476 NEL-like protein 2 isoform d [Homo sapiens]
          Length = 839

 Score = 1799 bits (4660), Expect = 0.0
 Identities = 816/816 (100%), Positives = 816/816 (100%)

Query: 1   MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF 60
           MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF
Sbjct: 24  MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF 83

Query: 61  QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG 120
           QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG
Sbjct: 84  QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG 143

Query: 121 HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS 180
           HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS
Sbjct: 144 HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS 203

Query: 181 TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK 240
           TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK
Sbjct: 204 TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK 263

Query: 241 IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT 300
           IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT
Sbjct: 264 IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT 323

Query: 301 IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE 360
           IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE
Sbjct: 324 IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE 383

Query: 361 CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA 420
           CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA
Sbjct: 384 CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA 443

Query: 421 VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC 480
           VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC
Sbjct: 444 VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC 503

Query: 481 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV 540
           TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV
Sbjct: 504 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV 563

Query: 541 CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
           CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC
Sbjct: 564 CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 623

Query: 601 EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC 660
           EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC
Sbjct: 624 EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC 683

Query: 661 SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ 720
           SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ
Sbjct: 684 SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ 743

Query: 721 QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV 780
           QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV
Sbjct: 744 QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV 803

Query: 781 RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL 816
           RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL
Sbjct: 804 RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL 839


>gi|223029472 NEL-like protein 2 isoform b precursor [Homo sapiens]
          Length = 816

 Score = 1799 bits (4660), Expect = 0.0
 Identities = 816/816 (100%), Positives = 816/816 (100%)

Query: 1   MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF 60
           MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF
Sbjct: 1   MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF 60

Query: 61  QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG 120
           QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG
Sbjct: 61  QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG 120

Query: 121 HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS 180
           HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS
Sbjct: 121 HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS 180

Query: 181 TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK 240
           TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK
Sbjct: 181 TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK 240

Query: 241 IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT 300
           IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT
Sbjct: 241 IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT 300

Query: 301 IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE 360
           IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE
Sbjct: 301 IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE 360

Query: 361 CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA 420
           CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA
Sbjct: 361 CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA 420

Query: 421 VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC 480
           VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC
Sbjct: 421 VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC 480

Query: 481 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV 540
           TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV
Sbjct: 481 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV 540

Query: 541 CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
           CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC
Sbjct: 541 CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600

Query: 601 EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC 660
           EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC
Sbjct: 601 EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC 660

Query: 661 SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ 720
           SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ
Sbjct: 661 SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ 720

Query: 721 QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV 780
           QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV
Sbjct: 721 QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV 780

Query: 781 RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL 816
           RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL
Sbjct: 781 RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL 816


>gi|223029470 NEL-like protein 2 isoform a [Homo sapiens]
          Length = 866

 Score = 1799 bits (4660), Expect = 0.0
 Identities = 816/816 (100%), Positives = 816/816 (100%)

Query: 1   MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF 60
           MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF
Sbjct: 51  MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF 110

Query: 61  QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG 120
           QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG
Sbjct: 111 QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG 170

Query: 121 HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS 180
           HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS
Sbjct: 171 HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS 230

Query: 181 TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK 240
           TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK
Sbjct: 231 TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK 290

Query: 241 IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT 300
           IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT
Sbjct: 291 IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT 350

Query: 301 IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE 360
           IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE
Sbjct: 351 IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE 410

Query: 361 CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA 420
           CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA
Sbjct: 411 CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA 470

Query: 421 VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC 480
           VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC
Sbjct: 471 VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC 530

Query: 481 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV 540
           TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV
Sbjct: 531 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV 590

Query: 541 CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
           CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC
Sbjct: 591 CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 650

Query: 601 EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC 660
           EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC
Sbjct: 651 EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC 710

Query: 661 SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ 720
           SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ
Sbjct: 711 SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ 770

Query: 721 QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV 780
           QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV
Sbjct: 771 QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV 830

Query: 781 RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL 816
           RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL
Sbjct: 831 RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL 866


>gi|5453766 NEL-like protein 2 isoform b precursor [Homo sapiens]
          Length = 816

 Score = 1799 bits (4660), Expect = 0.0
 Identities = 816/816 (100%), Positives = 816/816 (100%)

Query: 1   MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF 60
           MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF
Sbjct: 1   MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF 60

Query: 61  QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG 120
           QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG
Sbjct: 61  QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG 120

Query: 121 HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS 180
           HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS
Sbjct: 121 HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS 180

Query: 181 TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK 240
           TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK
Sbjct: 181 TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK 240

Query: 241 IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT 300
           IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT
Sbjct: 241 IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT 300

Query: 301 IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE 360
           IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE
Sbjct: 301 IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE 360

Query: 361 CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA 420
           CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA
Sbjct: 361 CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA 420

Query: 421 VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC 480
           VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC
Sbjct: 421 VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC 480

Query: 481 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV 540
           TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV
Sbjct: 481 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV 540

Query: 541 CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
           CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC
Sbjct: 541 CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600

Query: 601 EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC 660
           EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC
Sbjct: 601 EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC 660

Query: 661 SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ 720
           SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ
Sbjct: 661 SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ 720

Query: 721 QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV 780
           QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV
Sbjct: 721 QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV 780

Query: 781 RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL 816
           RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL
Sbjct: 781 RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL 816


>gi|223029474 NEL-like protein 2 isoform c [Homo sapiens]
          Length = 815

 Score = 1765 bits (4571), Expect = 0.0
 Identities = 798/799 (99%), Positives = 799/799 (100%)

Query: 18  AVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTPRSIKASTATAEQF 77
           +VWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTPRSIKASTATAEQF
Sbjct: 17  SVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTPRSIKASTATAEQF 76

Query: 78  FQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNEVRLHYRSGSHRPH 137
           FQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNEVRLHYRSGSHRPH
Sbjct: 77  FQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNEVRLHYRSGSHRPH 136

Query: 138 TEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLPLGTTFWLGQRNNA 197
           TEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLPLGTTFWLGQRNNA
Sbjct: 137 TEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLPLGTTFWLGQRNNA 196

Query: 198 HGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILAKTSAKLSR 257
           HGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILAKTSAKLSR
Sbjct: 197 HGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILAKTSAKLSR 256

Query: 258 AEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKS 317
           AEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKS
Sbjct: 257 AEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKS 316

Query: 318 ALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPAL 377
           ALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPAL
Sbjct: 317 ALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPAL 376

Query: 378 DCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAY 437
           DCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAY
Sbjct: 377 DCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAY 436

Query: 438 CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENA 497
           CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENA
Sbjct: 437 CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENA 496

Query: 498 LCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDID 557
           LCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDID
Sbjct: 497 LCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDID 556

Query: 558 ECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDT 617
           ECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDT
Sbjct: 557 ECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDT 616

Query: 618 ICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVC 677
           ICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVC
Sbjct: 617 ICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVC 676

Query: 678 DCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCP 737
           DCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCP
Sbjct: 677 DCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCP 736

Query: 738 DVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLC 797
           DVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLC
Sbjct: 737 DVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLC 796

Query: 798 QCKNGHICCSVDPQCLQEL 816
           QCKNGHICCSVDPQCLQEL
Sbjct: 797 QCKNGHICCSVDPQCLQEL 815


>gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens]
          Length = 810

 Score = 1047 bits (2707), Expect = 0.0
 Identities = 452/813 (55%), Positives = 586/813 (72%), Gaps = 13/813 (1%)

Query: 5   VLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTP 64
           +L+  FC+      V G G+DP LQ+D++TEL+L  +T GV QV G+HN +KAFLFQD  
Sbjct: 6   ILVVWFCVCTARTVV-GFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIE 64

Query: 65  RSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNE 124
           R I A+   +E+  Q  RNK EFTIL T++Q    SGVILSI  L+H Y ELESSG R+E
Sbjct: 65  REIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDE 124

Query: 125 VRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLP 184
           +R HY     +P TE  PY +AD +WHK++L++SASHL+LH+DCN+IYERV++ P T+LP
Sbjct: 125 IRYHYIHNG-KPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDTNLP 183

Query: 185 LGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMEL 244
            G   WLGQRN  HG FKGI+QD +++ MP G+I QCP+LN TCPTC+DF  LVQ IM+L
Sbjct: 184 PGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGIMDL 243

Query: 245 QDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDG--CKNCTCLNGTIQ 302
           Q++LAK +AKL+ AE R+++L+ C+CE+TC + G  YR+ +SW+DG  C+NCTC +G ++
Sbjct: 244 QELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVE 303

Query: 303 CETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECK 362
           C  + CP  +C   S   ++ G+CCK C+  C + G+   EG+R    S        EC+
Sbjct: 304 CRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCR------ECR 357

Query: 363 DQTM-KLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAV 421
              + K+ E   CP L+C E   I   + CC+VC+G++FC+E   C ENS C+N N +A 
Sbjct: 358 GGVLVKITEM--CPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKAT 415

Query: 422 CSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCT 481
           C C+ G+ +++ D+AYCEDIDECA   HYC  NT+CVN PG + C C  GYIR+DD+SCT
Sbjct: 416 CECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCT 475

Query: 482 EHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVC 541
           EHDEC + QHNCDENA+C NTV GH+C CKPGY GNGT C+AFC++GCR GG C+A N C
Sbjct: 476 EHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKC 535

Query: 542 ACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE 601
            CP GFTG  CE DIDECS+G ++C + + C+NLPGWYHCECR G+HD+G +S SGESC 
Sbjct: 536 VCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCI 595

Query: 602 DIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS 661
           DIDEC    H+C ND+ C NL GG+DC CP G +C+GDC H+G +KHNGQ+W L+ DRCS
Sbjct: 596 DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCS 655

Query: 662 VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQ 721
           VCSC++G + CRR  CDC+NP+ DLFCCPECD R++SQCL QNG  LY SGD W  +CQQ
Sbjct: 656 VCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQ 715

Query: 722 CRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVR 781
           CRCL+GEVDCWPL CP++ CE++ + E ECCPRCV+DPC AD I  DI KTCLD   V R
Sbjct: 716 CRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSR 775

Query: 782 FTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQ 814
            +GS W   G+ CT C+CKNG +CCSVD +CLQ
Sbjct: 776 LSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQ 808



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 50/192 (26%), Positives = 80/192 (41%), Gaps = 34/192 (17%)

Query: 635 NCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLF------- 687
           +C   C   G +  +   WV + D C  C+C++G V CRRM C   N + D         
Sbjct: 268 HCEKTCQVSGLLYRDQDSWV-DGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQ 326

Query: 688 CCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCR---CLQGEVDCWPLPCPDVECEFS 744
           CC  C P+    C++  G+ L        ++C++CR    ++    C PL C + +    
Sbjct: 327 CCKVCRPK----CIY-GGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKD---H 378

Query: 745 ILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHI 804
           ILPEN+CC  C      A+  +      C            +W    T    C+CK+G+I
Sbjct: 379 ILPENQCCRVCRGHNFCAEGPKCGENSEC-----------KNWNTKAT----CECKSGYI 423

Query: 805 CCSVDPQCLQEL 816
               D    +++
Sbjct: 424 SVQGDSAYCEDI 435


>gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens]
          Length = 763

 Score =  929 bits (2400), Expect = 0.0
 Identities = 420/813 (51%), Positives = 545/813 (67%), Gaps = 60/813 (7%)

Query: 5   VLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTP 64
           +L+  FC+      V G G+DP LQ+D++TEL+L  +T GV QV G+HN +KAFLFQD  
Sbjct: 6   ILVVWFCVCTARTVV-GFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIE 64

Query: 65  RSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNE 124
           R I A+   +E+  Q  RNK EFTIL T++Q    SGVILSI  L+H Y ELESSG R+E
Sbjct: 65  REIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDE 124

Query: 125 VRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLP 184
           +R HY     +P TE  PY +AD +WHK++L++SASHL+LH+DCN+IYERV++ P T+LP
Sbjct: 125 IRYHYIHNG-KPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDTNLP 183

Query: 185 LGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMEL 244
            G   WLGQRN  HG FKGI+QD +++ MP G+I QCP+LN TCPTC+DF  LVQ IM+L
Sbjct: 184 PGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGIMDL 243

Query: 245 QDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDG--CKNCTCLNGTIQ 302
           Q++LAK +AKL+ AE R+++L+ C+CE+TC + G  YR+ +SW+DG  C+NCTC +G ++
Sbjct: 244 QELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVE 303

Query: 303 CETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECK 362
           C  + CP  +C   S   ++ G+CCK C+  C + G+   EG+R    S        EC+
Sbjct: 304 CRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCR------ECR 357

Query: 363 DQTM-KLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAV 421
              + K+ E   CP L+C E   I   + CC+VC+G++FC+E   C ENS C+N N +A 
Sbjct: 358 GGVLVKITEM--CPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKAT 415

Query: 422 CSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCT 481
           C C+ G+ +++ D+AYCEDIDECA   HYC  NT+CVN PG + C C  GYIR+DD+SCT
Sbjct: 416 CECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCT 475

Query: 482 EHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVC 541
           EHDEC + QHNCDENA+C NTV GH+C CKPGY GNGT C+AFC++GCR GG C+A N C
Sbjct: 476 EHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKC 535

Query: 542 ACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE 601
            CP GFTG  CE DIDEC+     C + + CINL G + C C           PSG S  
Sbjct: 536 VCPSGFTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLC-----------PSGPS-- 582

Query: 602 DIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS 661
                                             C+GDC H+G +KHNGQ+W L+ DRCS
Sbjct: 583 ----------------------------------CSGDCPHEGGLKHNGQVWTLKEDRCS 608

Query: 662 VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQ 721
           VCSC++G + CRR  CDC+NP+ DLFCCPECD R++SQCL QNG  LY SGD W  +CQQ
Sbjct: 609 VCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQ 668

Query: 722 CRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVR 781
           CRCL+GEVDCWPL CP++ CE++ + E ECCPRCV+DPC AD I  DI KTCLD   V R
Sbjct: 669 CRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSR 728

Query: 782 FTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQ 814
            +GS W   G+ CT C+CKNG +CCSVD +CLQ
Sbjct: 729 LSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQ 761



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 50/192 (26%), Positives = 80/192 (41%), Gaps = 34/192 (17%)

Query: 635 NCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLF------- 687
           +C   C   G +  +   WV + D C  C+C++G V CRRM C   N + D         
Sbjct: 268 HCEKTCQVSGLLYRDQDSWV-DGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQ 326

Query: 688 CCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCR---CLQGEVDCWPLPCPDVECEFS 744
           CC  C P+    C++  G+ L        ++C++CR    ++    C PL C + +    
Sbjct: 327 CCKVCRPK----CIY-GGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKD---H 378

Query: 745 ILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHI 804
           ILPEN+CC  C      A+  +      C            +W    T    C+CK+G+I
Sbjct: 379 ILPENQCCRVCRGHNFCAEGPKCGENSEC-----------KNWNTKAT----CECKSGYI 423

Query: 805 CCSVDPQCLQEL 816
               D    +++
Sbjct: 424 SVQGDSAYCEDI 435


>gi|66346695 fibrillin 2 precursor [Homo sapiens]
          Length = 2912

 Score =  166 bits (421), Expect = 6e-41
 Identities = 136/474 (28%), Positives = 187/474 (39%), Gaps = 75/474 (15%)

Query: 343  EGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCS 402
            E ERN +    G CV             + G    DCP  H+++ S    + C   + CS
Sbjct: 1161 ECERNPLLCRGGTCV------------NTEGSFQCDCPLGHELSPSR---EDCVDINECS 1205

Query: 403  ERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPG 462
               N   N  C N+     CSC  G++A   D   C DIDEC      C  +T C N+ G
Sbjct: 1206 LSDNLCRNGKCVNMIGTYQCSCNPGYQA-TPDRQGCTDIDECMIMNGGC--DTQCTNSEG 1262

Query: 463  SFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTC 521
            S+ C C  GY +  D  SC + DEC  N   CD    C N  G + C+C  G+  +    
Sbjct: 1263 SYECSCSEGYALMPDGRSCADIDECENNPDICD-GGQCTNIPGEYRCLCYDGFMASMDMK 1321

Query: 522  KAFCKDGC-RNGGACI--------AANVCACPQGFT---GPSCETDIDECSDGFVQCDSR 569
                 + C  N   C+         + +C C  G++   G +  TD+DEC  G   CD  
Sbjct: 1322 TCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMH 1381

Query: 570  ANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCR 629
            A+C+N+PG + C CR+G+  NG+       C D+DEC  G H C+ +  C N  G Y C 
Sbjct: 1382 ASCLNIPGSFKCSCREGWIGNGI------KCIDLDECSNGTHQCSINAQCVNTPGSYRCA 1435

Query: 630  CPHGKNCTG-------DCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCENP 682
            C  G    G       +C  +  +  NGQ   L       C C+ GF            P
Sbjct: 1436 CSEGFTGDGFTCSDVDECAENINLCENGQ--CLNVPGAYRCECEMGF-----------TP 1482

Query: 683  TVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQG-EVDCWPLPCPDV-E 740
              D   C + D     +C  QN        +  +     C C  G E+D     C D+ E
Sbjct: 1483 ASDSRSCQDID-----ECSFQNICVFGTCNN--LPGMFHCICDDGYELDRTGGNCTDIDE 1535

Query: 741  CEFSILPENECC---PRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHG 791
            C   I   N  C   P      C  D   N     C+D        G+ ++K G
Sbjct: 1536 CADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNR-----VGNCYLKFG 1584



 Score =  164 bits (415), Expect = 3e-40
 Identities = 104/299 (34%), Positives = 137/299 (45%), Gaps = 26/299 (8%)

Query: 393  KVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCR 452
            K C   + C    N      C N     +C C+ G+ ++++    C D+DEC  G H C 
Sbjct: 1321 KTCIDVNECDLNSNICMFGECENTKGSFICHCQLGY-SVKKGTTGCTDVDECEIGAHNCD 1379

Query: 453  ENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKP 512
             +  C+N PGSF C C+ G+I  +   C + DEC    H C  NA C NT G + C C  
Sbjct: 1380 MHASCLNIPGSFKCSCREGWIG-NGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSE 1438

Query: 513  GYTGNGTTCKAF--CKDG---CRNGGACI---AANVCACPQGFT----GPSCETDIDECS 560
            G+TG+G TC     C +    C N G C+    A  C C  GFT      SC+ DIDECS
Sbjct: 1439 GFTGDGFTCSDVDECAENINLCEN-GQCLNVPGAYRCECEMGFTPASDSRSCQ-DIDECS 1496

Query: 561  DGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICF 620
              F        C NLPG +HC C DGY        +G +C DIDEC     +C N  +C 
Sbjct: 1497 --FQNICVFGTCNNLPGMFHCICDDGYE----LDRTGGNCTDIDEC-ADPINCVNG-LCV 1548

Query: 621  NLDGGYDCRCP--HGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVC 677
            N  G Y+C CP     N TG    D +V +    +    D    C+ + G  + R   C
Sbjct: 1549 NTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCC 1607



 Score =  139 bits (350), Expect = 1e-32
 Identities = 89/289 (30%), Positives = 127/289 (43%), Gaps = 25/289 (8%)

Query: 399  DFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCV 458
            D C E      N +C N      C C  GF +  +    CEDIDEC+ G + C+ N  C+
Sbjct: 1810 DECKEIPGICANGVCINQIGSFRCECPTGF-SYNDLLLVCEDIDECSNGDNLCQRNADCI 1868

Query: 459  NTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNG 518
            N+PGS+ C C  G+    + +C + +EC+   + C  + LC +  G + C+C  G+  + 
Sbjct: 1869 NSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVC-SHGLCVDLQGSYQCICHNGFKASQ 1927

Query: 519  TTCKAFCKDGCR----NGGAC---IAANVCACPQGF--TGPSCETDIDECSDGFVQCDSR 569
                    D C       G C   + +  C C  GF  T  +   DIDECS  F Q    
Sbjct: 1928 DQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRN 1987

Query: 570  ANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCR 629
              C N  G + C C +GY      +P G++C D +EC     SC+  T C NL+G + C 
Sbjct: 1988 GRCFNEIGSFKCLCNEGYE----LTPDGKNCIDTNECVALPGSCSPGT-CQNLEGSFRCI 2042

Query: 630  CPHG-----KNC--TGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVM 671
            CP G     +NC    +C  D  +   G            C C  GFV+
Sbjct: 2043 CPPGYEVKSENCIDINECDEDPNICLFGS--CTNTPGGFQCLCPPGFVL 2089



 Score =  135 bits (341), Expect = 1e-31
 Identities = 103/322 (31%), Positives = 132/322 (40%), Gaps = 63/322 (19%)

Query: 401  CSERHNCMENSI-----CRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCR-EN 454
            C + + C +N +     C N      C+C  G+ ALRED   C+D+DECAEG H C    
Sbjct: 2251 CEDINECAQNPLLCAFRCMNTFGSYECTCPIGY-ALREDQKMCKDLDECAEGLHDCESRG 2309

Query: 455  TMCVNTPGSFMCICKTGYI-RIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPG 513
             MC N  G+FMCIC  G   R D   C + +EC T    C EN  C N +G + C C  G
Sbjct: 2310 MMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGIC-ENGRCVNIIGSYRCECNEG 2368

Query: 514  Y--TGNGTTC-------------KAFCK------------DGCRNGGACIAANVCACPQG 546
            +  + +GT C             +  C+            + C +GG         CP  
Sbjct: 2369 FQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLP 2428

Query: 547  FT---------GPSCET---DIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFS 594
             T         GP   T   DIDEC      C +   CIN  G + C C+ GY  +    
Sbjct: 2429 GTAQYKKICPHGPGYTTDGRDIDECKVMPNLC-TNGQCINTMGSFRCFCKVGYTTD---- 2483

Query: 595  PSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPH-------GKNCTGDCIHDGKVK 647
             SG SC D+DEC      C  + IC N +G Y C CP        GK C  D       +
Sbjct: 2484 ISGTSCIDLDECSQSPKPC--NYICKNTEGSYQCSCPRGYVLQEDGKTCK-DLDECQTKQ 2540

Query: 648  HNGQIWVLENDRCSVCSCQNGF 669
            HN Q   +       C C  GF
Sbjct: 2541 HNCQFLCVNTLGGFTCKCPPGF 2562



 Score =  133 bits (334), Expect = 8e-31
 Identities = 89/280 (31%), Positives = 132/280 (47%), Gaps = 34/280 (12%)

Query: 395  CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
            C   D CS+      N IC+N      CSC  G+  L+ED   C+D+DEC   +H C+  
Sbjct: 2489 CIDLDECSQSPKPC-NYICKNTEGSYQCSCPRGY-VLQEDGKTCKDLDECQTKQHNCQ-- 2544

Query: 455  TMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGY 514
             +CVNT G F C C  G+ +    +C +++EC +    C    +C NT G  +C C+ G+
Sbjct: 2545 FLCVNTLGGFTCKCPPGFTQ-HHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGF 2603

Query: 515  T--GNGTTCKAF--------CKDGCRNGGACIAANVCACPQG----FTGPSCETDIDECS 560
            +    G  C+          C+ GC+N    +    C CPQG    +    C  D +ECS
Sbjct: 2604 SLDATGLNCEDVDECDGNHRCQHGCQN---ILGGYRCGCPQGYIQHYQWNQC-VDENECS 2659

Query: 561  DGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICF 620
            +    C S A+C N  G Y C C  G+     F     +C D++EC + ++ C  +  C 
Sbjct: 2660 NPNA-CGS-ASCYNTLGSYKCACPSGF----SFDQFSSACHDVNECSSSKNPC--NYGCS 2711

Query: 621  NLDGGYDCRCPHG--KNCTGDCIHDGKVKHNGQIWVLEND 658
            N +GGY C CP G  +   G C+  G   + GQ   L+ +
Sbjct: 2712 NTEGGYLCGCPPGYYRVGQGHCV-SGMGFNKGQYLSLDTE 2750



 Score =  132 bits (331), Expect = 2e-30
 Identities = 126/467 (26%), Positives = 173/467 (37%), Gaps = 97/467 (20%)

Query: 338  GRTYFEGERNTVYSSSGVCVLYECKDQ--TMKLVESSGCPALDCPESHQITLSHSCCKVC 395
            GR +++ + N   +  G+C   +C++   + K   +SG  ALD  E +           C
Sbjct: 1067 GRPFYK-DINECKAFPGMCTYGKCRNTIGSFKCRCNSGF-ALDMEERN-----------C 1113

Query: 396  KGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENT 455
               D C    +   + IC N      C C +G+ +       C DIDEC      CR  T
Sbjct: 1114 TDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGT 1173

Query: 456  MCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGY 514
             CVNT GSF C C  G+ +      C + +EC  + + C  N  C N +G + C C PGY
Sbjct: 1174 -CVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLC-RNGKCVNMIGTYQCSCNPGY 1231

Query: 515  --TGNGTTCKAFCKDGCRNGGA---CI---AANVCACPQGFT----GPSCETDIDECSDG 562
              T +   C    +    NGG    C     +  C+C +G+     G SC  DIDEC + 
Sbjct: 1232 QATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC-ADIDECENN 1290

Query: 563  FVQCDSRANCINLPGWYHCECRDGY----------------------------HDNGMF- 593
               CD    C N+PG Y C C DG+                            +  G F 
Sbjct: 1291 PDICDG-GQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFI 1349

Query: 594  ---------SPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDG 644
                           C D+DEC  G H+C     C N+ G + C C  G    G    D 
Sbjct: 1350 CHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDL 1409

Query: 645  KVKHNGQIWVLENDRC------SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSS 698
                NG      N +C        C+C  GF             T D F C + D    +
Sbjct: 1410 DECSNGTHQCSINAQCVNTPGSYRCACSEGF-------------TGDGFTCSDVDECAEN 1456

Query: 699  QCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCW-PLPCPDV-ECEF 743
              L +NG+ L       V    +C C  G         C D+ EC F
Sbjct: 1457 INLCENGQCLN------VPGAYRCECEMGFTPASDSRSCQDIDECSF 1497



 Score =  126 bits (316), Expect = 9e-29
 Identities = 116/404 (28%), Positives = 171/404 (42%), Gaps = 74/404 (18%)

Query: 437  YCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDE 495
            + +DI+EC      C     C NT GSF C C +G+ + +++ +CT+ DEC  +   C  
Sbjct: 1070 FYKDINECKAFPGMCTYGK-CRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCG- 1127

Query: 496  NALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDG---------CRNGGACIAAN---VCAC 543
            + +C NT G   C C  GY  +G      C D          CR GG C+       C C
Sbjct: 1128 SGICVNTPGSFECECFEGYE-SGFMMMKNCMDIDECERNPLLCR-GGTCVNTEGSFQCDC 1185

Query: 544  PQGFT-GPSCE--TDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
            P G    PS E   DI+ECS     C +   C+N+ G Y C C  GY      +P  + C
Sbjct: 1186 PLGHELSPSREDCVDINECSLSDNLCRN-GKCVNMIGTYQCSCNPGYQA----TPDRQGC 1240

Query: 601  EDIDECGTGRHSCANDTICFNLDGGYDCRC-------PHGKNCTG--DCIHDGKVKHNGQ 651
             DIDEC      C  DT C N +G Y+C C       P G++C    +C ++  +   GQ
Sbjct: 1241 TDIDECMIMNGGC--DTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQ 1298

Query: 652  IWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNS 711
               +  +    C C +GF+    M        +D+    ECD   S+ C+    E   N+
Sbjct: 1299 CTNIPGEYR--CLCYDGFMASMDM-----KTCIDV---NECDLN-SNICMFGECE---NT 1344

Query: 712  GDTWVQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITK 771
              +++ +CQ    L   V      C DV                  D C+      D+  
Sbjct: 1345 KGSFICHCQ----LGYSVKKGTTGCTDV------------------DECEIGAHNCDMHA 1382

Query: 772  TCLDEMNVVRFT-GSSWIKHGTECT-LCQCKNGHICCSVDPQCL 813
            +CL+     + +    WI +G +C  L +C NG   CS++ QC+
Sbjct: 1383 SCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCV 1426



 Score =  119 bits (299), Expect = 9e-27
 Identities = 120/423 (28%), Positives = 162/423 (38%), Gaps = 86/423 (20%)

Query: 393 KVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCR 452
           + C   D C +     +N  C N +    C C  GF  L  D   C D DEC    + C 
Sbjct: 571 QACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFE-LTTDGKNCVDHDECTT-TNMCL 628

Query: 453 ENTMCVNTPGSFMCICKTGYIRI-DDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCK 511
            N MC+N  GSF CICK G++   +   CT+ DEC T       N  C N+ G   C C 
Sbjct: 629 -NGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQT--PGICMNGHCINSEGSFRCDCP 685

Query: 512 PGYT--GNGTTC-----KAFCKDGCRNG-------GACIAAN-VCACPQGFTGPSCE--- 553
           PG     +G  C     ++ C  G + G       GA   +   CA P    G  C+   
Sbjct: 686 PGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCP 745

Query: 554 ---------------------TDIDECSDGFVQCDSRAN--CINLPGWYHCECRDGYHDN 590
                                 DI+EC+   +  D  AN  C NL G Y C C  GY  +
Sbjct: 746 AKNSAEFHGLCSSGVGITVDGRDINECA---LDPDICANGICENLRGSYRCNCNSGYEPD 802

Query: 591 GMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNG 650
                SG +C DIDEC   R  C N  +C N  G Y C CP G       +   + +   
Sbjct: 803 A----SGRNCIDIDECLVNRLLCDNG-LCRNTPGSYSCTCPPG------YVFRTETETCE 851

Query: 651 QIWVLENDRCSVCSCQNGFVMCRRMVCDC----ENPTVDLFCCPECDPRL-----SSQC- 700
            I   E++ C   +C+N         C+C    +  +  L C              S+C 
Sbjct: 852 DINECESNPCVNGACRNNL---GSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCE 908

Query: 701 LHQNGETLYNS-----GDTWVQNCQQCR----CLQGEVDCWPLPCPDV-ECEF--SILPE 748
           ++ NG TL +      G  W   C++C     C +G      + C DV ECE    + P 
Sbjct: 909 VNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPN 968

Query: 749 NEC 751
             C
Sbjct: 969 GRC 971



 Score =  117 bits (292), Expect = 6e-26
 Identities = 118/458 (25%), Positives = 168/458 (36%), Gaps = 99/458 (21%)

Query: 385  ITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDEC 444
            ++ S  CC + K +      + C       +     +C   +GFR         EDIDEC
Sbjct: 1601 VSRSSCCCSLGKAWG-----NPCETCPPVNSTEYYTLCPGGEGFRP-NPITIILEDIDEC 1654

Query: 445  AEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYS-CTEHDECITNQHNCDENALCFNTV 503
             E    C+    C+NT GSF C C  GY   +D   C + DEC  +   C     C+NT+
Sbjct: 1655 QELPGLCQGGN-CINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGT-CYNTL 1712

Query: 504  GGHNCVCKPGY-------------------TGNGTTC--------------------KAF 524
            G + C+C P Y                   + NGTTC                    KA+
Sbjct: 1713 GNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAW 1772

Query: 525  CK--DGCRNGGACIAANVCACPQGFT---GPSCETDIDECSDGFVQCDSRANCINLPGWY 579
             K  + C   G      +C    GFT         DIDEC +    C +   CIN  G +
Sbjct: 1773 NKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGIC-ANGVCINQIGSF 1831

Query: 580  HCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCT-- 637
             CEC  G+  N +       CEDIDEC  G + C  +  C N  G Y C C  G   +  
Sbjct: 1832 RCECPTGFSYNDLLL----VCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPN 1887

Query: 638  ------GDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVM------------CRRMVC-- 677
                   +C+    V  +G    L+      C C NGF              C R  C  
Sbjct: 1888 GACVDRNECLEIPNVCSHGLCVDLQGS--YQCICHNGFKASQDQTMCMDVDECERHPCGN 1945

Query: 678  -DCENP--TVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPL 734
              C+N   + +  C P  +   ++ CL      +      + Q C+  RC   E+  +  
Sbjct: 1946 GTCKNTVGSYNCLCYPGFELTHNNDCL-----DIDECSSFFGQVCRNGRCF-NEIGSFKC 1999

Query: 735  PCPDVECEFSILPENECC---PRCVTDP--CQADTIRN 767
             C +    + + P+ + C     CV  P  C   T +N
Sbjct: 2000 LCNE---GYELTPDGKNCIDTNECVALPGSCSPGTCQN 2034



 Score =  108 bits (269), Expect = 3e-23
 Identities = 146/613 (23%), Positives = 214/613 (34%), Gaps = 157/613 (25%)

Query: 292  KNCTCLN--GTIQCETL----ICPNPDCPLKSALAYVDGKC----CKECKSICQFQGRTY 341
            +N  C+N  G+ +CE      + PN  C  ++    +   C    C + +   Q      
Sbjct: 1863 RNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNG 1922

Query: 342  FEGERN-TVYSSSGVCVLYECKDQTMK---------------LVESSGCPALDCPESH-- 383
            F+  ++ T+      C  + C + T K               L  ++ C  +D   S   
Sbjct: 1923 FKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFG 1982

Query: 384  QITLSHSC--------CKVCKGYDFCSERHNCMENS------------ICRNLNDRAVCS 423
            Q+  +  C        C   +GY+   +  NC++ +             C+NL     C 
Sbjct: 1983 QVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCI 2042

Query: 424  CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDD-YSC-- 480
            C  G+    E+   C DI+EC E  + C   + C NTPG F C+C  G++  D+   C  
Sbjct: 2043 CPPGYEVKSEN---CIDINECDEDPNICLFGS-CTNTPGGFQCLCPPGFVLSDNGRRCFD 2098

Query: 481  TEHDECITNQHNCDENALC-----FNTVGGHNCVCKPGYTGNGTTCKAFCKD-------- 527
            T    C TN     EN  C     FNT     C  K    G G  C+   KD        
Sbjct: 2099 TRQSFCFTN----FENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDL 2154

Query: 528  -------------------------GCRNGGACIAAN---VCACPQG----FTGPSCETD 555
                                     G  + G CI  +    C CP G    +TG  C  D
Sbjct: 2155 CPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRC-VD 2213

Query: 556  IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCAN 615
             DECS G         C N+ G + C C +G+    M      +CEDI+EC      CA 
Sbjct: 2214 TDECSIG--NPCGNGTCTNVIGSFECNCNEGFEPGPMM-----NCEDINECAQNPLLCA- 2265

Query: 616  DTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS--VCSCQNGFVMCR 673
               C N  G Y+C CP G     D           Q    + D C+  +  C++  +MC+
Sbjct: 2266 -FRCMNTFGSYECTCPIGYALRED-----------QKMCKDLDECAEGLHDCESRGMMCK 2313

Query: 674  RMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNC------QQCRCLQG 727
             ++      T    C P    R   +      E     G      C       +C C +G
Sbjct: 2314 NLI-----GTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEG 2368

Query: 728  EVDCWPLPCPDVECEFSILPENECCPRCVTDPCQ-ADTIRNDITKT--CLDEMNVVRFTG 784
                +       EC  +   +  C    +   CQ A + RN +TK+  C D        G
Sbjct: 2369 ----FQSSSSGTECLDN--RQGLCFAEVLQTICQMASSSRNLVTKSECCCD-------GG 2415

Query: 785  SSWIKHGTECTLC 797
              W   G +C LC
Sbjct: 2416 RGW---GHQCELC 2425



 Score =  107 bits (268), Expect = 3e-23
 Identities = 104/366 (28%), Positives = 140/366 (38%), Gaps = 61/366 (16%)

Query: 291 CKNCTCLN--GTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNT 348
           C N  C+N  G+ +C        DCP   A+  +DG+ C +                R+T
Sbjct: 668 CMNGHCINSEGSFRC--------DCPPGLAVG-MDGRVCVDTHM-------------RST 705

Query: 349 VYSS--SGVCVLYE----------CKDQTMKLVES-SGCPALDCPESHQITLSHSCCKVC 395
            Y     GVCV             C +      E    CPA +  E H +  S     V 
Sbjct: 706 CYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITV- 764

Query: 396 KGYDF--CSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRE 453
            G D   C+   +   N IC NL     C+C  G+         C DIDEC   R  C +
Sbjct: 765 DGRDINECALDPDICANGICENLRGSYRCNCNSGYEP-DASGRNCIDIDECLVNRLLC-D 822

Query: 454 NTMCVNTPGSFMCICKTGYI-RIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKP 512
           N +C NTPGS+ C C  GY+ R +  +C + +EC +N   C  N  C N +G  NC C P
Sbjct: 823 NGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNP--C-VNGACRNNLGSFNCECSP 879

Query: 513 GYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANC 572
           G   + T            G  CI +    C        CE +I+  +     C +    
Sbjct: 880 GSKLSST------------GLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAA 927

Query: 573 INLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPH 632
              P    CE  D     G+    G +CED++EC      C N   C N  G + C CP 
Sbjct: 928 WGSP-CERCEL-DTACPRGLARIKGVTCEDVNECEVFPGVCPNGR-CVNSKGSFHCECPE 984

Query: 633 GKNCTG 638
           G    G
Sbjct: 985 GLTLDG 990



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 67/208 (32%), Positives = 91/208 (43%), Gaps = 26/208 (12%)

Query: 439 EDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENAL 498
           + ID C    + C  N  C+ T  S+ C C  GY +  +  C + DEC +N   C  N  
Sbjct: 493 QTIDICKHHANLCL-NGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNP--C-TNGD 548

Query: 499 CFNTVGGHNCVCKPGYTGNGTTCKAFCKDGC-RNG-----GACIAAN---VCACPQGF-- 547
           C NT G + C C  G+    T       D C +NG     G C+  +    C C  GF  
Sbjct: 549 CVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFEL 608

Query: 548 --TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDE 605
              G +C  D DEC+           CIN  G + C C+ G+    + +P+G  C D+DE
Sbjct: 609 TTDGKNC-VDHDECTT--TNMCLNGMCINEDGSFKCICKPGF----VLAPNGRYCTDVDE 661

Query: 606 CGTGRHSCANDTICFNLDGGYDCRCPHG 633
           C T    C N   C N +G + C CP G
Sbjct: 662 CQT-PGICMNGH-CINSEGSFRCDCPPG 687



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 79/297 (26%), Positives = 107/297 (36%), Gaps = 77/297 (25%)

Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEH 483
           C  G++ L   N     I   + G  +C    MC  + G     C +  I+         
Sbjct: 97  CCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQ--------- 147

Query: 484 DECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTC-KAFCKDGCRNGGACIAANVCA 542
                    C    +   T    +C C+ GY G  T C +  C++GC+NGG CI  N CA
Sbjct: 148 --------QCSVRCMNGGTCADDHCQCQKGYIG--TYCGQPVCENGCQNGGRCIGPNRCA 197

Query: 543 CPQGFTGPSCETDI----------DECSDG---FVQCDSRANCINL-PGWYH-CE----- 582
           C  GFTGP CE D           ++   G    + C     C  +   W H CE     
Sbjct: 198 CVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQ 257

Query: 583 ---CRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG---KNC 636
              CR G+  N        +C+D+DEC      C     C N  G ++CRCP G      
Sbjct: 258 PQPCRRGFIPNIRTG----ACQDVDECQAIPGICQGGN-CINTVGSFECRCPAGHKQSET 312

Query: 637 TGDCIHDGKVKHNGQIWVLENDRCSVCS--CQNGFVMCRRMVCDCENPTVDLFC-CP 690
           T  C               + D CS+    C+ G         +C N     FC CP
Sbjct: 313 TQKC--------------EDIDECSIIPGICETG---------ECSNTVGSYFCVCP 346



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 97/388 (25%), Positives = 132/388 (34%), Gaps = 101/388 (26%)

Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
           C+  D C       +   C N      C C  G +   E    CEDIDEC+     C E 
Sbjct: 274 CQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQ-SETTQKCEDIDECSIIPGIC-ET 331

Query: 455 TMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHN-CDE---NALCFNTVGGH---- 506
             C NT GS+ C+C  GY+     + T+   CI  +   C     N  C   + G     
Sbjct: 332 GECSNTVGSYFCVCPRGYV-----TSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKM 386

Query: 507 NCVCKPGYT-GNGTTCKA-----------FCKDGCRNGGACIAANVCACP-----QGFTG 549
            C C+PG   G GT  +A            C DG   GG  I  +  + P      GF  
Sbjct: 387 QCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGLPMGG--IPGSAGSRPGGTGGNGFAP 444

Query: 550 PSCETDIDECSDGFVQ-------------------------------------CDSRAN- 571
                       GF+                                      C   AN 
Sbjct: 445 SGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANL 504

Query: 572 -----CINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGY 626
                CI     Y CEC  GY  +     +   C D+DEC +  + C N   C N  G Y
Sbjct: 505 CLNGRCIPTVSSYRCECNMGYKQD-----ANGDCIDVDECTS--NPCTNGD-CVNTPGSY 556

Query: 627 DCRCPHGKNCT---------GDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVC 677
            C+C  G   T          +CI +G +  NG+   +  D    C C  GF     +  
Sbjct: 557 YCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGR--CVNTDGSFQCICNAGF----ELTT 610

Query: 678 DCENPTVDLFCCPECDPRLSSQCLHQNG 705
           D +N  VD   C   +  L+  C++++G
Sbjct: 611 DGKN-CVDHDECTTTNMCLNGMCINEDG 637



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 77/288 (26%), Positives = 101/288 (35%), Gaps = 76/288 (26%)

Query: 389 HSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCED--IDECAE 446
           HS C  C G+      + C+   ICRN       SC DGF + R +   C    I     
Sbjct: 94  HSYC--CPGWKTLPGGNQCIV-PICRN-------SCGDGFCS-RPNMCTCSSGQISSTCG 142

Query: 447 GRHYCRENTMCVN--TPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVG 504
            +   + +  C+N  T     C C+ GYI     +      C   ++ C     C   +G
Sbjct: 143 SKSIQQCSVRCMNGGTCADDHCQCQKGYIG----TYCGQPVC---ENGCQNGGRC---IG 192

Query: 505 GHNCVCKPGYTG----------------NGTTCKAFCKDGCRNGGACIAANVCA------ 542
            + C C  G+TG                N   C+     G   G  C     CA      
Sbjct: 193 PNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQ-----GQLTGIVCTKTLCCATIGRAW 247

Query: 543 -------------CPQGFTGPSCET----DIDECSDGFVQCDSRANCINLPGWYHCECRD 585
                        C +GF  P+  T    D+DEC      C    NCIN  G + C C  
Sbjct: 248 GHPCEMCPAQPQPCRRGFI-PNIRTGACQDVDECQAIPGICQG-GNCINTVGSFECRCPA 305

Query: 586 GYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG 633
           G+      S + + CEDIDEC      C     C N  G Y C CP G
Sbjct: 306 GHKQ----SETTQKCEDIDECSIIPGICETGE-CSNTVGSYFCVCPRG 348



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 59/223 (26%), Positives = 85/223 (38%), Gaps = 55/223 (24%)

Query: 294  CTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSS 353
            C C  G  Q  T    N +C  + +L           K ICQ           NT  S  
Sbjct: 2556 CKCPPGFTQHHTACIDNNECGSQPSLC--------GAKGICQ-----------NTPGS-- 2594

Query: 354  GVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSIC 413
                 + C+ Q    ++++G                     C+  D C   H C     C
Sbjct: 2595 -----FSCECQRGFSLDATGLN-------------------CEDVDECDGNHRCQHG--C 2628

Query: 414  RNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYI 473
            +N+     C C  G+    + N  C D +EC+        +  C NT GS+ C C +G+ 
Sbjct: 2629 QNILGGYRCGCPQGYIQHYQWN-QCVDENECSNPN--ACGSASCYNTLGSYKCACPSGF- 2684

Query: 474  RIDDYSCTEHD--ECITNQHNCDENALCFNTVGGHNCVCKPGY 514
              D +S   HD  EC ++++ C  N  C NT GG+ C C PGY
Sbjct: 2685 SFDQFSSACHDVNECSSSKNPC--NYGCSNTEGGYLCGCPPGY 2725



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 67/241 (27%), Positives = 83/241 (34%), Gaps = 58/241 (24%)

Query: 396 KGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENT 455
           K    CS R  CM    C + +    C C+ G+        YC     C  G   C+   
Sbjct: 144 KSIQQCSVR--CMNGGTCADDH----CQCQKGYIG-----TYCGQ-PVCENG---CQNGG 188

Query: 456 MCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHN--CD--------ENALCFNTVG- 504
            C+   G   C C  G+             C T  +N  C            LC  T+G 
Sbjct: 189 RCI---GPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGR 245

Query: 505 --GHNCV--------CKPGYTGNGTTCKAFCKDGCR------NGGACI---AANVCACPQ 545
             GH C         C+ G+  N  T      D C+       GG CI    +  C CP 
Sbjct: 246 AWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPA 305

Query: 546 GF----TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE 601
           G     T   CE DIDECS     C++   C N  G Y C C  GY    + S  G  C 
Sbjct: 306 GHKQSETTQKCE-DIDECSIIPGICET-GECSNTVGSYFCVCPRGY----VTSTDGSRCI 359

Query: 602 D 602
           D
Sbjct: 360 D 360


>gi|24430141 fibrillin 1 precursor [Homo sapiens]
          Length = 2871

 Score =  157 bits (397), Expect = 4e-38
 Identities = 93/251 (37%), Positives = 120/251 (47%), Gaps = 24/251 (9%)

Query: 393  KVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCR 452
            K C   + C    N   +  C N     +C C  G+   ++    C DI+EC  G H C 
Sbjct: 1276 KTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSG-KKGKTGCTDINECEIGAHNCG 1334

Query: 453  ENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKP 512
            ++ +C NT GSF C C  G+I  D   CT+ DEC    H C ++A C NT+G + C+CK 
Sbjct: 1335 KHAVCTNTAGSFKCSCSPGWIG-DGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKE 1393

Query: 513  GYTGNGTTCKAF--CKDG---CRNGGACIAA---NVCACPQGFT----GPSCETDIDECS 560
            GYTG+G TC     C +    C N G C+ A     C C  GF     G +CE DIDECS
Sbjct: 1394 GYTGDGFTCTDLDECSENLNLCGN-GQCLNAPGGYRCECDMGFVPSADGKACE-DIDECS 1451

Query: 561  DGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICF 620
                       C NLPG + CEC  GY        SG +C D++EC     +C +   C 
Sbjct: 1452 --LPNICVFGTCHNLPGLFRCECEIGYE----LDRSGGNCTDVNEC-LDPTTCISGN-CV 1503

Query: 621  NLDGGYDCRCP 631
            N  G Y C CP
Sbjct: 1504 NTPGSYICDCP 1514



 Score =  150 bits (379), Expect = 5e-36
 Identities = 151/556 (27%), Positives = 211/556 (37%), Gaps = 87/556 (15%)

Query: 288  IDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDG-KCCKECKSICQFQGRTYFEGER 346
            ID C+    L G  QC   +    D   K    Y  G    K C  I + Q        R
Sbjct: 1071 IDECRISPDLCGRGQC---VNTPGDFECKCDEGYESGFMMMKNCMDIDECQ--------R 1119

Query: 347  NTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHN 406
            + +    GVC              + G    +CP  HQ++ + S C      + C    +
Sbjct: 1120 DPLLCRGGVCH------------NTEGSYRCECPPGHQLSPNISACI---DINECELSAH 1164

Query: 407  CMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMC 466
               N  C NL  +  C+C  G+ +   D  +C DIDEC+     C   T C N+ GS+ C
Sbjct: 1165 LCPNGRCVNLIGKYQCACNPGYHST-PDRLFCVDIDECSIMNGGCE--TFCTNSEGSYEC 1221

Query: 467  ICKTGYIRIDDY-SCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFC 525
             C+ G+  + D  SCT+ DEC  N + CD    C N  G + C+C  G+  +        
Sbjct: 1222 SCQPGFALMPDQRSCTDIDECEDNPNICD-GGQCTNIPGEYRCLCYDGFMASEDMKTCVD 1280

Query: 526  KDGCR-NGGACIAAN--------VCACPQGFTGPSCET---DIDECSDGFVQCDSRANCI 573
             + C  N   C++          +C C  G++G   +T   DI+EC  G   C   A C 
Sbjct: 1281 VNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCT 1340

Query: 574  NLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG 633
            N  G + C C  G+  +G+       C D+DEC  G H C+    C N  G Y C C  G
Sbjct: 1341 NTAGSFKCSCSPGWIGDGI------KCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEG 1394

Query: 634  K-----NCT--GDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFV-----MCRRMVCDCEN 681
                   CT   +C  +  +  NGQ   L       C C  GFV          + +C  
Sbjct: 1395 YTGDGFTCTDLDECSENLNLCGNGQ--CLNAPGGYRCECDMGFVPSADGKACEDIDECSL 1452

Query: 682  PTVDLFCCPECDPRLSSQCLHQNGETLYNSGD--TWVQNC-QQCRCLQGEVDCWP----L 734
            P + +F      P L  +C  + G  L  SG   T V  C     C+ G     P     
Sbjct: 1453 PNICVFGTCHNLPGL-FRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYIC 1511

Query: 735  PCPDVECEFSILPENECCPRCVTDPCQAD-TIRNDITKT-CLDEMNV-------VRFTGS 785
             CP    +F + P    C    +  C  D   R D   T C +E+ V           G 
Sbjct: 1512 DCPP---DFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGK 1568

Query: 786  SWIKHGTECTLCQCKN 801
            +W   GT C +C   N
Sbjct: 1569 AW---GTPCEMCPAVN 1581



 Score =  145 bits (366), Expect = 1e-34
 Identities = 140/482 (29%), Positives = 186/482 (38%), Gaps = 79/482 (16%)

Query: 291  CKNCTCLNGTIQCETLICPNPDCPLKSALAYVDG--KCCKECKSICQFQGRTYF------ 342
            C   TC N T+   T ICP PD         V+G   C    +S+C    R Y+      
Sbjct: 1658 CGPGTCYN-TVGNYTCICP-PD------YMQVNGGNNCMDMRRSLCY---RNYYADNQTC 1706

Query: 343  EGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALD-----CPESHQITLSHSCCKVCKG 397
            +GE     +    C  Y       K  E    P+ D     C       +      +   
Sbjct: 1707 DGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVD 1766

Query: 398  YDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMC 457
             D C E     EN +C N+     C C  GF    +    CEDIDEC  G   C+ N  C
Sbjct: 1767 IDECREIPGVCENGVCINMVGSFRCECPVGF-FYNDKLLVCEDIDECQNG-PVCQRNAEC 1824

Query: 458  VNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGN 517
            +NT GS+ C CK GY       C + +EC    + C  +  C +TVG   C+C  G+  N
Sbjct: 1825 INTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNIC-SHGQCIDTVGSFYCLCHTGFKTN 1883

Query: 518  G--TTCKAF--C-KDGCRNGGA--CIAANVCACPQGFT---GPSCETDIDECSDGFVQCD 567
               T C     C +D C NG     I +  C C  GF       C  D+DEC+ G     
Sbjct: 1884 DDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDC-IDVDECASGNGNLC 1942

Query: 568  SRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYD 627
                CIN  G + C+C +GY      +P G +C DI+EC      CA  T C NLDG Y 
Sbjct: 1943 RNGQCINTVGSFQCQCNEGYE----VAPDGRTCVDINECLLEPRKCAPGT-CQNLDGSYR 1997

Query: 628  CRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC-SVCSCQNGFVMCRRMVCDCENPTVDL 686
            C CP G                   + L+N++C  +  C     +C   +  C N     
Sbjct: 1998 CICPPG-------------------YSLQNEKCEDIDECVEEPEIC--ALGTCSNTEGSF 2036

Query: 687  FC-CPE----------CDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRC-LQGEVDCWPL 734
             C CPE          C     S C  +      +S  +   + Q+C C L+GE   W  
Sbjct: 2037 KCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGE--GWGD 2094

Query: 735  PC 736
            PC
Sbjct: 2095 PC 2096



 Score =  143 bits (361), Expect = 6e-34
 Identities = 126/421 (29%), Positives = 169/421 (40%), Gaps = 62/421 (14%)

Query: 235  HGLVQKIMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNC 294
            H   +K ME ++++           QR    + C  E  C  K             C+N 
Sbjct: 2256 HDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGI----------CENG 2305

Query: 295  TCLN--GTIQCET----LICPNPDCPLKSALAYVDGKCCKEC-KSICQFQGRTYFEGERN 347
             CLN  G+  CE        PN D      L   +G C  E  +++CQ          RN
Sbjct: 2306 RCLNTRGSYTCECNDGFTASPNQD----ECLDNREGYCFTEVLQNMCQIGS-----SNRN 2356

Query: 348  TVYSSSGVCVLYECKDQTMKLVESSGCPALD--CPESHQITLSHSCCKVCKGYDFCSERH 405
             V  S   C          ++    G  A    CP       + +        D C   H
Sbjct: 2357 PVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGA------DIDECKVIH 2410

Query: 406  NCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFM 465
            +   N  C N      C C+ G+       + C D++EC +    C  N +C NT GS+ 
Sbjct: 2411 DVCRNGECVNDRGSYHCICKTGYTPDITGTS-CVDLNECNQAPKPC--NFICKNTEGSYQ 2467

Query: 466  CICKTGYIRIDD-YSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTC--K 522
            C C  GYI  +D  SC + DEC T QHNC    LC NT+GG  C C PG+T + T+C   
Sbjct: 2468 CSCPKGYILQEDGRSCKDLDECATKQHNCQ--FLCVNTIGGFTCKCPPGFTQHHTSCIDN 2525

Query: 523  AFCKDG---CRNGGACI---AANVCACPQGF----TGPSCETDIDECSDGFVQCDSRANC 572
              C      C + G C     +  C C +GF    TG SCE D+DEC +G  +C     C
Sbjct: 2526 NECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCE-DVDEC-EGNHRCQH--GC 2581

Query: 573  INLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPH 632
             N+ G Y C C  GY  +  ++     C D +EC    H C   + C N  G Y C CP 
Sbjct: 2582 QNIIGGYRCSCPQGYLQHYQWN----QCVDENEC-LSAHICGGAS-CHNTLGSYKCMCPA 2635

Query: 633  G 633
            G
Sbjct: 2636 G 2636



 Score =  142 bits (358), Expect = 1e-33
 Identities = 164/616 (26%), Positives = 227/616 (36%), Gaps = 140/616 (22%)

Query: 191  LGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILAK 250
            LG  +N  G FK         + P+GF      L+ +   C D        + +    AK
Sbjct: 2026 LGTCSNTEGSFK--------CLCPEGF-----SLSSSGRRCQD--------LRMSYCYAK 2064

Query: 251  -TSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICP 309
                K S  + R +   +C     C +KG      E W D C+              +CP
Sbjct: 2065 FEGGKCSSPKSRNHSKQEC----CCALKG------EGWGDPCE--------------LCP 2100

Query: 310  N-PD------CPLKSAL------AYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVC 356
              PD      CP  S +      + VD   CKE   +C+       +G          + 
Sbjct: 2101 TEPDEAFRQICPYGSGIIVGPDDSAVDMDECKE-PDVCKHGQCINTDGSYRCECPFGYIL 2159

Query: 357  VLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYD-----FCSERHNCMENS 411
               EC D T +    + C    C       +    C   +G++      C + + C +N 
Sbjct: 2160 AGNECVD-TDECSVGNPCGNGTCKN----VIGGFECTCEEGFEPGPMMTCEDINECAQNP 2214

Query: 412  I-----CRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTM-CVNTPGSFM 465
            +     C N      C C  G+  LRED   C+D DEC EG+H C E  M C N  G++M
Sbjct: 2215 LLCAFRCVNTYGSYECKCPVGY-VLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYM 2273

Query: 466  CICKTGY-IRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTG--NGTTC- 521
            CIC  GY  R D   C + +EC T    C EN  C NT G + C C  G+T   N   C 
Sbjct: 2274 CICGPGYQRRPDGEGCVDENECQTKPGIC-ENGRCLNTRGSYTCECNDGFTASPNQDECL 2332

Query: 522  ---KAFC-----KDGCRNGGA---CIAANVCACPQG-FTGPSCE---------------- 553
               + +C     ++ C+ G +    +  + C C  G   GP CE                
Sbjct: 2333 DNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPH 2392

Query: 554  --------TDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDE 605
                     DIDEC      C     C+N  G YHC C+ GY  +     +G SC D++E
Sbjct: 2393 GRGFMTNGADIDECKVIHDVC-RNGECVNDRGSYHCICKTGYTPD----ITGTSCVDLNE 2447

Query: 606  CGTGRHSCANDTICFNLDGGYDCRCP-------HGKNCTGDCIHDGKVKHNGQIWVLEND 658
            C      C  + IC N +G Y C CP        G++C  D       +HN Q   +   
Sbjct: 2448 CNQAPKPC--NFICKNTEGSYQCSCPKGYILQEDGRSCK-DLDECATKQHNCQFLCVNTI 2504

Query: 659  RCSVCSCQNGFVMCRRMVCDCENPTVDLFCCPE---CDPRLSS-QCLHQNGETLYNSGDT 714
                C C  GF        D    T D+  C     C     S  C  Q G +L  +G +
Sbjct: 2505 GGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSS 2564

Query: 715  W--VQNCQ-QCRCLQG 727
               V  C+   RC  G
Sbjct: 2565 CEDVDECEGNHRCQHG 2580



 Score =  122 bits (306), Expect = 1e-27
 Identities = 135/511 (26%), Positives = 189/511 (36%), Gaps = 102/511 (19%)

Query: 369 VESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGF 428
           + + G     C   +Q TL+ +    C+  D C +      N  C N +    C C  GF
Sbjct: 505 INNQGSYTCQCRAGYQSTLTRT---ECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGF 561

Query: 429 RALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECI 487
              R D   CED+DEC+  R+ C  N MC+N  GSF CICK G+ +  D   C + +EC 
Sbjct: 562 HVTR-DGKNCEDMDECSI-RNMCL-NGMCINEDGSFKCICKPGFQLASDGRYCKDINECE 618

Query: 488 TNQHNCDENALCFNTVGGHNCVCKPGYTG--NGTTC-----KAFCKDGCRNG-------G 533
           T       N  C NT G + C C PG     +G  C     ++ C  G + G       G
Sbjct: 619 T--PGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFG 676

Query: 534 ACIAANVCA-------------------------CPQGFTGPSCETDIDECSDGFVQCDS 568
           A   +  C                          C  G    S  +DI+EC+     C +
Sbjct: 677 AVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPN 736

Query: 569 RANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC 628
              C NL G Y C C  GY        +G++C DI+EC      C N   C N  G + C
Sbjct: 737 -GICENLRGTYKCICNSGYE----VDSTGKNCVDINECVLNSLLCDNGQ-CRNTPGSFVC 790

Query: 629 RCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRR----MVCDCENPTV 684
            CP G       I+   +K    I     D C    C NG  +C+      +C+C + + 
Sbjct: 791 TCPKG------FIYKPDLKTCEDI-----DECESSPCING--VCKNSPGSFICECSSEST 837

Query: 685 DLFCCPECDPRLSSQC----------LHQNGETLYNS-----GDTWVQNCQQCR----CL 725
                  C   +   C          ++ NG TL +      G  W   C  C+    C 
Sbjct: 838 LDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICG 897

Query: 726 QGEVDCWPLPCPDV-ECE-FSILPENECCPR---CVTDPCQADTIRNDITKTCLDEMNVV 780
           +G        C D+ ECE F  + +N  C          C +    +   + CLD    +
Sbjct: 898 KGYSRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLD----I 953

Query: 781 RFTGSSWIKHGTECTL---CQCKNGHICCSV 808
           R           ECTL    + +    CCSV
Sbjct: 954 RLETCFLRYEDEECTLPIAGRHRMDACCCSV 984



 Score =  115 bits (287), Expect = 2e-25
 Identities = 94/349 (26%), Positives = 138/349 (39%), Gaps = 86/349 (24%)

Query: 289  DGCKNCTCLN--GTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGER 346
            D C+N  C+N  G+  C   IC     P  +  + VD   C +    C F  +       
Sbjct: 2411 DVCRNGECVNDRGSYHC---ICKTGYTPDITGTSCVDLNECNQAPKPCNFICK------- 2460

Query: 347  NTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCS-ERH 405
            NT  S       Y+C                 CP+ +   +     + CK  D C+ ++H
Sbjct: 2461 NTEGS-------YQCS----------------CPKGY---ILQEDGRSCKDLDECATKQH 2494

Query: 406  NCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFM 465
            NC    +C N      C C  GF    + +  C D +EC    + C    +C NTPGSF 
Sbjct: 2495 NCQ--FLCVNTIGGFTCKCPPGFT---QHHTSCIDNNECTSDINLCGSKGICQNTPGSFT 2549

Query: 466  CICKTGY-IRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAF 524
            C C+ G+ +     SC + DEC  N H C     C N +GG+ C C  GY       + +
Sbjct: 2550 CECQRGFSLDQTGSSCEDVDECEGN-HRCQHG--CQNIIGGYRCSCPQGY------LQHY 2600

Query: 525  CKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECR 584
              + C +   C++A++C                            A+C N  G Y C C 
Sbjct: 2601 QWNQCVDENECLSAHIC--------------------------GGASCHNTLGSYKCMCP 2634

Query: 585  DGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG 633
             G+     +      C+DI+ECG+ +  C+    C N +GGY C CP G
Sbjct: 2635 AGF----QYEQFSGGCQDINECGSAQAPCSYG--CSNTEGGYLCGCPPG 2677



 Score =  114 bits (284), Expect = 5e-25
 Identities = 120/483 (24%), Positives = 168/483 (34%), Gaps = 122/483 (25%)

Query: 291  CKNCTCLN--GTIQCET----------LICPN-------PDCPLKSALAYVDGKCCKECK 331
            C+N  C+N  G+ +CE           L+C +       P C   +      G    +CK
Sbjct: 1777 CENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCK 1836

Query: 332  SICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSC 391
               +F   T    +RN       +C   +C D     V S  C            L H+ 
Sbjct: 1837 PGYRFTS-TGQCNDRNECQEIPNICSHGQCIDT----VGSFYC------------LCHTG 1879

Query: 392  CKVCKGYDFCSERHNCME----NSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEG 447
             K       C + + C      N  CRN      C C  GF  +   N  C D+DECA G
Sbjct: 1880 FKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGF--ILSHNNDCIDVDECASG 1937

Query: 448  RHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENALCFNTVGGH 506
                  N  C+NT GSF C C  GY +  D  +C + +EC+     C     C N  G +
Sbjct: 1938 NGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGT-CQNLDGSY 1996

Query: 507  NCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCA---------CPQGF----TGPSCE 553
             C+C PGY+     C+    D C       A   C+         CP+GF    +G  C+
Sbjct: 1997 RCICPPGYSLQNEKCEDI--DECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQ 2054

Query: 554  T----------DIDECSDGFVQCDSRANC---INLPGWYH-CECRDGYHD---------- 589
                       +  +CS    +  S+  C   +   GW   CE      D          
Sbjct: 2055 DLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYG 2114

Query: 590  NGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTG-DCIHDGKVKH 648
            +G+     +S  D+DEC            C N DG Y C CP G    G +C+       
Sbjct: 2115 SGIIVGPDDSAVDMDEC--KEPDVCKHGQCINTDGSYRCECPFGYILAGNECV------- 2165

Query: 649  NGQIWVLENDRCSV-----------------CSCQNGFVMCRRMVCD-----CENPTVDL 686
                   + D CSV                 C+C+ GF     M C+      +NP +  
Sbjct: 2166 -------DTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCA 2218

Query: 687  FCC 689
            F C
Sbjct: 2219 FRC 2221



 Score =  110 bits (274), Expect = 7e-24
 Identities = 135/558 (24%), Positives = 192/558 (34%), Gaps = 153/558 (27%)

Query: 290  GCKN-CTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNT 348
            GC+  CT   G+ +C    C      +    +  D   C++  +IC     T   GE   
Sbjct: 1207 GCETFCTNSEGSYECS---CQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRC 1263

Query: 349  VYSSSGVCVLYECKDQTMKLVESSGCPAL-DCPESHQITLSHSCCK-----VC------- 395
            +           C D  M   +   C  + +C  +  I LS +C       +C       
Sbjct: 1264 L-----------CYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYS 1312

Query: 396  --KGYDFCSE-------RHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAE 446
              KG   C++        HNC ++++C N      CSC  G+     D   C D+DEC+ 
Sbjct: 1313 GKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIG---DGIKCTDLDECSN 1369

Query: 447  GRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGH 506
            G H C ++  C NT GS+ C+CK GY   D ++CT+ DEC  N + C  N  C N  GG+
Sbjct: 1370 GTHMCSQHADCKNTMGSYRCLCKEGYTG-DGFTCTDLDECSENLNLCG-NGQCLNAPGGY 1427

Query: 507  NCVCKPGY--TGNGTTCKAF------------------------CKDGC---RNGGACIA 537
             C C  G+  + +G  C+                          C+ G    R+GG C  
Sbjct: 1428 RCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTD 1487

Query: 538  AN--------------------VCACPQGFT------------GPSCETDIDECSD-GFV 564
             N                    +C CP  F               +C  DI    D G  
Sbjct: 1488 VNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDT 1547

Query: 565  QCD-------SRANCINLPG--W-YHCECRDGYHDNG--MFSPSGES---------CEDI 603
             C        S+A+C    G  W   CE     + +   +  P GE           EDI
Sbjct: 1548 ACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDI 1607

Query: 604  DECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVC 663
            DEC      C     C N  G + CRCP G         D +V  +    V E +   +C
Sbjct: 1608 DECQELPGLCQGGK-CINTFGSFQCRCPTGYYLN----EDTRVCDD----VNECETPGIC 1658

Query: 664  SCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQ--------NGETL------- 708
                 +       C C    + +     C     S C           +GE L       
Sbjct: 1659 GPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKM 1718

Query: 709  ----YNSGDTWVQNCQQC 722
                YN G  W + C+QC
Sbjct: 1719 CCCSYNIGRAWNKPCEQC 1736



 Score = 99.8 bits (247), Expect = 9e-21
 Identities = 138/559 (24%), Positives = 203/559 (36%), Gaps = 157/559 (28%)

Query: 288  IDGCKNCTCLNGTIQCE--TLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGE 345
            ID C++  C+NG  +    + IC   +C  +S L      C +  K  C    +T  +G 
Sbjct: 808  IDECESSPCINGVCKNSPGSFIC---ECSSESTLDPTKTICIETIKGTC---WQTVIDG- 860

Query: 346  RNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERH 405
                 + +G  +  +C            C +L            S C +C+    C + +
Sbjct: 861  -RCEININGATLKSQC------------CSSLGAAWG-------SPCTLCQVDPICGKGY 900

Query: 406  NCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFM 465
            + ++ + C                         EDIDEC      C+ N +CVNT GSF 
Sbjct: 901  SRIKGTQC-------------------------EDIDECEVFPGVCK-NGLCVNTRGSFK 934

Query: 466  CICKTG------------------YIRIDDYSCT-------EHDECITN------QHNCD 494
            C C +G                  ++R +D  CT         D C  +         C+
Sbjct: 935  CQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECE 994

Query: 495  ENALCFNTVGGHNCVCKPGY-TGNGTTCKAFCKD--------------GCRNGGACIAAN 539
            E  +         C   PG+ T   T  K F KD               CRN    I + 
Sbjct: 995  ECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRN---TIGSF 1051

Query: 540  VCACPQGFTGPSCE---TDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPS 596
             C C  GF   S E   TDIDEC      C  R  C+N PG + C+C +GY    M    
Sbjct: 1052 KCRCDSGFALDSEERNCTDIDECRISPDLC-GRGQCVNTPGDFECKCDEGYESGFMMM-- 1108

Query: 597  GESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGD---CIHDGKVKHNGQIW 653
             ++C DIDEC      C    +C N +G Y C CP G   + +   CI   + + +  + 
Sbjct: 1109 -KNCMDIDECQRDPLLCRGG-VCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHL- 1165

Query: 654  VLENDRC------SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNG-- 705
               N RC        C+C  G+           + T D   C + D     +C   NG  
Sbjct: 1166 -CPNGRCVNLIGKYQCACNPGY-----------HSTPDRLFCVDID-----ECSIMNGGC 1208

Query: 706  ETL-YNSGDTWVQNCQQCRCLQGEVDCWPLPCPDV-ECEF--SILPENECCP-----RCV 756
            ET   NS  ++  +CQ    L  +       C D+ ECE   +I    +C       RC+
Sbjct: 1209 ETFCTNSEGSYECSCQPGFALMPD----QRSCTDIDECEDNPNICDGGQCTNIPGEYRCL 1264

Query: 757  TDPCQADTIRNDITKTCLD 775
               C    + ++  KTC+D
Sbjct: 1265 ---CYDGFMASEDMKTCVD 1280



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 68/202 (33%), Positives = 85/202 (42%), Gaps = 26/202 (12%)

Query: 442 DECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFN 501
           D C   R+ C +N  C+ TPGS  C C  G+       C + DEC  N     E   C N
Sbjct: 451 DYCQLVRYLC-QNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCAGGE---CIN 506

Query: 502 TVGGHNCVCKPGYTGNGTTCKAFCKDGCR------NGGACIAAN---VCACPQGF----T 548
             G + C C+ GY    T  +    D C       N G CI  +    C C  GF     
Sbjct: 507 NQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRD 566

Query: 549 GPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGT 608
           G +CE D+DECS           CIN  G + C C+ G+      +  G  C+DI+EC T
Sbjct: 567 GKNCE-DMDECS--IRNMCLNGMCINEDGSFKCICKPGF----QLASDGRYCKDINECET 619

Query: 609 GRHSCANDTICFNLDGGYDCRC 630
               C N   C N DG Y C C
Sbjct: 620 -PGICMNGR-CVNTDGSYRCEC 639



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 70/262 (26%), Positives = 97/262 (37%), Gaps = 63/262 (24%)

Query: 396 KGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENT 455
           KG + C  R+N                 C  G++ L   N     I   + G  +C    
Sbjct: 54  KGPNVCGSRYNAY---------------CCPGWKTLPGGNQCIVPICRHSCGDGFCSRPN 98

Query: 456 MCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYT 515
           MC    G     C +  I+  +  C     C  +                 +C+C+ GY 
Sbjct: 99  MCTCPSGQIAPSCGSRSIQHCNIRCMNGGSCSDD-----------------HCLCQKGYI 141

Query: 516 GNGTTC-KAFCKDGCRNGGACIAANVCACPQGFTGPSCETDI----------DECSDG-- 562
           G  T C +  C+ GC NGG C+A N CAC  GFTGP CE D           ++   G  
Sbjct: 142 G--THCGQPVCESGCLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQL 199

Query: 563 -FVQCDSRANCINL-PGWYH-CE--------CRDGYHDNGMFSPSGESCEDIDECGTGRH 611
             + C     C  +   W H CE        CR G+  N        +C+D+DEC     
Sbjct: 200 SGIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNIRTG----ACQDVDECQAIPG 255

Query: 612 SCANDTICFNLDGGYDCRCPHG 633
            C     C N  G ++C+CP G
Sbjct: 256 LCQGGN-CINTVGSFECKCPAG 276



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 42/143 (29%), Positives = 64/143 (44%), Gaps = 24/143 (16%)

Query: 572 CINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCP 631
           CI  PG   CEC  G+         GE C D+DEC   ++ CA    C N  G Y C+C 
Sbjct: 465 CIPTPGSCRCECNKGFQ----LDLRGE-CIDVDECE--KNPCAGGE-CINNQGSYTCQCR 516

Query: 632 HGKNCT---------GDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCENP 682
            G   T          +C+ +G++ +NG+   +  D    C C  GF + R    +CE  
Sbjct: 517 AGYQSTLTRTECRDIDECLQNGRICNNGR--CINTDGSFHCVCNAGFHVTRDGK-NCE-- 571

Query: 683 TVDLFCCPECDPRLSSQCLHQNG 705
             D+  C   +  L+  C++++G
Sbjct: 572 --DMDECSIRNMCLNGMCINEDG 592



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 47/188 (25%), Positives = 67/188 (35%), Gaps = 11/188 (5%)

Query: 294  CTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSI-CQFQGRTYFEGERNTVYSS 352
            C C  G  Q  T    N +C     L    G C     S  C+ Q     +   ++    
Sbjct: 2509 CKCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDV 2568

Query: 353  SGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSI 412
                  + C+     ++    C    CP+ +   L H     C   + C   H C   S 
Sbjct: 2569 DECEGNHRCQHGCQNIIGGYRC---SCPQGY---LQHYQWNQCVDENECLSAHICGGAS- 2621

Query: 413  CRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY 472
            C N      C C  GF+   + +  C+DI+EC   +  C     C NT G ++C C  GY
Sbjct: 2622 CHNTLGSYKCMCPAGFQ-YEQFSGGCQDINECGSAQAPCSYG--CSNTEGGYLCGCPPGY 2678

Query: 473  IRIDDYSC 480
             RI    C
Sbjct: 2679 FRIGQGHC 2686



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 140/628 (22%), Positives = 205/628 (32%), Gaps = 162/628 (25%)

Query: 267  QCYCERTCTMKGTTYREFESWIDG---CKNCTCLN--GTIQCETLICPNPDCPLKSALAY 321
            +C C+   T  G T  + +   +    C N  CLN  G  +CE        C +   +  
Sbjct: 1388 RCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCE--------CDM-GFVPS 1438

Query: 322  VDGKCCK---ECK--SICQFQGRTY-----FEGERNTVYS---SSGVCV-LYECKDQTMK 367
             DGK C+   EC   +IC F G  +     F  E    Y    S G C  + EC D T  
Sbjct: 1439 ADGKACEDIDECSLPNICVF-GTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTC 1497

Query: 368  L----VESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCS 423
            +    V + G    DCP   ++  +   C   +         NC  +   R  N    CS
Sbjct: 1498 ISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRS-------GNCYLDIRPRGDNGDTACS 1550

Query: 424  CRDGFRALREDNAYCEDIDECAEGRHYCRENTMC--VNTPGSFMCICKTGY--------I 473
               G    +           C+ G+ +     MC  VNT   +  +C  G         +
Sbjct: 1551 NEIGVGVSKASCC-------CSLGKAWGTPCEMCPAVNT-SEYKILCPGGEGFRPNPITV 1602

Query: 474  RIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGG 533
             ++D      DEC      C +   C NT G   C C  GY  N  T      + C   G
Sbjct: 1603 ILEDI-----DECQELPGLC-QGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPG 1656

Query: 534  AC--------IAANVCACPQGFT----GPSC-ETDIDECSDGFVQCDSRANCINLPGWYH 580
             C        +    C CP  +     G +C +     C   +   +   +   L     
Sbjct: 1657 ICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTK 1716

Query: 581  CECRDGYHDNGMFSPSGESCE----------------------------DIDECGTGRHS 612
              C   Y+    ++   E C                             DIDEC      
Sbjct: 1717 KMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGV 1776

Query: 613  CANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMC 672
            C N  +C N+ G + C CP G              +N ++ V E+    +  CQNG V C
Sbjct: 1777 CENG-VCINMVGSFRCECPVG------------FFYNDKLLVCED----IDECQNGPV-C 1818

Query: 673  RRMVCDCENPTVDLFCCPECDP--RLSS--QCLHQNGETLYNSGDTWVQNCQQCR--CLQ 726
            +R   +C N      C  +C P  R +S  QC  +N              CQ+    C  
Sbjct: 1819 QRN-AECINTAGSYRC--DCKPGYRFTSTGQCNDRN-------------ECQEIPNICSH 1862

Query: 727  GEVDCWPLPCPDVECEFSIL-----PENECCPRCV-TDPCQADTIRNDITKTCLDEMNVV 780
            G+       C D    F  L       N+    C+  + C+ D   N   +  +   N  
Sbjct: 1863 GQ-------CIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFN-C 1914

Query: 781  RFTGSSWIKHGTEC---TLCQCKNGHIC 805
            R      + H  +C     C   NG++C
Sbjct: 1915 RCNHGFILSHNNDCIDVDECASGNGNLC 1942



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 39/124 (31%), Positives = 51/124 (41%), Gaps = 20/124 (16%)

Query: 447 GRHYCRENTMCVNTPGSFMCICKTGYI-RIDDYSCTEHDECITNQHNCDENALCFNTVGG 505
           GR +     MC   P      C+ G+I  I   +C + DEC      C +   C NTVG 
Sbjct: 214 GRAWGHPCEMCPAQPHP----CRRGFIPNIRTGACQDVDECQAIPGLC-QGGNCINTVGS 268

Query: 506 HNCVCKPGYTGNGTTCKAFCKD--------GCRNGGAC---IAANVCACPQGF-TGPSCE 553
             C C  G+  N  + K  C+D        G   GG C   +++  C CP GF T P   
Sbjct: 269 FECKCPAGHKLNEVSQK--CEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGT 326

Query: 554 TDID 557
             ID
Sbjct: 327 RCID 330


>gi|56237021 fibrillin 3 precursor [Homo sapiens]
          Length = 2809

 Score =  156 bits (395), Expect = 6e-38
 Identities = 112/366 (30%), Positives = 159/366 (43%), Gaps = 37/366 (10%)

Query: 291  CKNCTCLN--GTIQCET-----LICPNPDCPLKSALAYVDGKCCK-ECKSICQFQGRTYF 342
            C+  TC N  G+ +C+      L      C      +  DG C   +C ++      +  
Sbjct: 1082 CRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCH 1141

Query: 343  EGERNTVYSSSGVCVLYECKDQT----MKLVESSGCPALDCPESHQITLSHSCCKVCKGY 398
             G ++T     G   + EC+ Q     +  + + G     C + + +       + C   
Sbjct: 1142 AGFQSTP-DRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDG---RACADV 1197

Query: 399  DFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCV 458
            D C E     +   C N+     C C DGF A   D   C D+DEC    H C     C 
Sbjct: 1198 DECEENPRVCDQGHCTNMPGGHRCLCYDGFMAT-PDMRTCVDVDECDLNPHICLHGD-CE 1255

Query: 459  NTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGN 517
            NT GSF+C C+ GY +R     C++ DEC    HNCD +A C N  G  +C C PG+ G+
Sbjct: 1256 NTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGD 1315

Query: 518  GTTCKAF--C---KDGCRNGGACI---AANVCACPQGFTGPS--CETDIDECSDGFVQCD 567
            G  C     C   +  C   G C+    +  C C QGF G    CE D DEC++    CD
Sbjct: 1316 GFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCE-DRDECAENVDLCD 1374

Query: 568  SRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYD 627
            +   C+N PG Y CEC  G+      +    +C+D+DEC  G + CA  + C NL G + 
Sbjct: 1375 N-GQCLNAPGGYRCECEMGFDP----TEDHRACQDVDECAQG-NLCAFGS-CENLPGMFR 1427

Query: 628  CRCPHG 633
            C C  G
Sbjct: 1428 CICNGG 1433



 Score =  144 bits (363), Expect = 3e-34
 Identities = 159/541 (29%), Positives = 208/541 (38%), Gaps = 92/541 (17%)

Query: 266  DQCYCERTCT-----MKGTT---YREFESWIDGCKNCTCLN--GTIQCETLICPNPDCPL 315
            ++C  +  C      M G T     E ES+   C N  C+N  G+ +CE        CP 
Sbjct: 847  ERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCE--------CP- 897

Query: 316  KSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCP 375
            +  +    G+ C + +    F    + E E            +  C    +  VE   CP
Sbjct: 898  EGLMLDASGRLCVDVRLEPCFL--RWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACP 955

Query: 376  ALDCPESHQIT------LSHSCCKVCKGYDFCSERHNCM------ENSICRNLNDRAVCS 423
                PES +        L  +      G  F  + + C        +  CRN      C+
Sbjct: 956  D---PESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCA 1012

Query: 424  CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIR--IDDYSCT 481
            C  GF AL      C DIDEC      C + T CVNTPGSF C C  GY    +   +C 
Sbjct: 1013 CAGGF-ALDAQERNCTDIDECRISPDLCGQGT-CVNTPGSFECECFPGYESGFMLMKNCM 1070

Query: 482  EHDECITNQHNCDENALCFNTVGGHNCVCKPGY--TGNGTTC----KAFCKDGCRNGGAC 535
            + DEC  +   C     C NT G + C C PG+  T  GT C    +    DG    G C
Sbjct: 1071 DVDECARDPLLC-RGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQC 1129

Query: 536  ---IAANVCACPQGFTG----PSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYH 588
               I A  C+C  GF        C  DI+EC      CD   +CIN  G Y C C  GY 
Sbjct: 1130 VNVIGAFQCSCHAGFQSTPDRQGC-VDINECRVQNGGCD--VHCINTEGSYRCSCGQGY- 1185

Query: 589  DNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGD---CIHDGK 645
                  P G +C D+DEC      C +   C N+ GG+ C C  G   T D   C+   +
Sbjct: 1186 ---SLMPDGRACADVDECEENPRVC-DQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDE 1241

Query: 646  VKHNGQIWV---LENDRCS-VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCL 701
               N  I +    EN + S VC CQ G+ M R+    C +          CD   S  CL
Sbjct: 1242 CDLNPHICLHGDCENTKGSFVCHCQLGY-MVRKGATGCSDVDECEVGGHNCDSHAS--CL 1298

Query: 702  HQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDV-ECEFSILPENECCPR--CVTD 758
            +  G                CRCL G V      C D+ EC   +  E+ C PR  C+  
Sbjct: 1299 NIPGSF-------------SCRCLPGWVGD-GFECHDLDEC---VSQEHRCSPRGDCLNV 1341

Query: 759  P 759
            P
Sbjct: 1342 P 1342



 Score =  134 bits (337), Expect = 3e-31
 Identities = 101/339 (29%), Positives = 143/339 (42%), Gaps = 56/339 (16%)

Query: 313  CPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCV----LYECKDQTMKL 368
            CPL    AY   K C         +GR   E        + G C+     + C  Q    
Sbjct: 2339 CPLPGTSAY--RKLCPHGSGYTA-EGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYT 2395

Query: 369  VESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGF 428
             +++    LD  E         C +V K   F           +C+N     +CSC  G+
Sbjct: 2396 PDATATTCLDMDE---------CSQVPKPCTF-----------LCKNTKGSFLCSCPRGY 2435

Query: 429  RALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECIT 488
              L ED   C+D+DEC   +H C+   +CVNT G+F C C  G+ +    +C ++DEC  
Sbjct: 2436 -LLEEDGRTCKDLDECTSRQHNCQ--FLCVNTVGAFTCRCPPGFTQ-HHQACFDNDECSA 2491

Query: 489  NQHNCDENALCFNTVGGHNCVCKPGYT--GNGTTCKAF--------CKDGCRNGGACIAA 538
                C  +  C NT G   C C  G+T   +G  C+          C+ GC+N    +  
Sbjct: 2492 QPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQ---LGG 2548

Query: 539  NVCACPQGFTGPS----CETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFS 594
              C+CPQGFT  S    C  D +EC+     C S A+C N  G + C C  G+     F 
Sbjct: 2549 YRCSCPQGFTQHSQWAQC-VDENECALSPPTCGS-ASCRNTLGGFRCVCPSGFD----FD 2602

Query: 595  PSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG 633
             +   C+++DEC   R  C+    C N  GG+ C CP G
Sbjct: 2603 QALGGCQEVDECAGRRGPCSYS--CANTPGGFLCGCPQG 2639



 Score =  130 bits (326), Expect = 6e-30
 Identities = 102/372 (27%), Positives = 140/372 (37%), Gaps = 84/372 (22%)

Query: 371  SSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRA 430
            + G     CP  H++T   + C+     D CS       +  C N+     CSC  GF++
Sbjct: 1090 TDGSYKCQCPPGHELTAKGTACE---DIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQS 1146

Query: 431  LREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITN 489
               D   C DI+EC      C  +  C+NT GS+ C C  GY +  D  +C + DEC  N
Sbjct: 1147 T-PDRQGCVDINECRVQNGGC--DVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEEN 1203

Query: 490  QHNCDENALCFNTVGGHNCVCKPGY--TGNGTTCKAFCKDGCRNGGACIAANVCACPQGF 547
               CD+   C N  GGH C+C  G+  T +  TC                          
Sbjct: 1204 PRVCDQGH-CTNMPGGHRCLCYDGFMATPDMRTC-------------------------- 1236

Query: 548  TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECG 607
                   D+DEC      C    +C N  G + C C+ GY    M       C D+DEC 
Sbjct: 1237 ------VDVDECDLNPHIC-LHGDCENTKGSFVCHCQLGY----MVRKGATGCSDVDECE 1285

Query: 608  TGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSV----- 662
             G H+C +   C N+ G + CRC  G       + DG   H+    V +  RCS      
Sbjct: 1286 VGGHNCDSHASCLNIPGSFSCRCLPG------WVGDGFECHDLDECVSQEHRCSPRGDCL 1339

Query: 663  -------CSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTW 715
                   C+C+ GF               D F C + D    +  L  NG+ L   G   
Sbjct: 1340 NVPGSYRCTCRQGF-------------AGDGFFCEDRDECAENVDLCDNGQCLNAPGG-- 1384

Query: 716  VQNCQQCRCLQG 727
                 +C C  G
Sbjct: 1385 ----YRCECEMG 1392



 Score =  122 bits (307), Expect = 1e-27
 Identities = 84/287 (29%), Positives = 117/287 (40%), Gaps = 21/287 (7%)

Query: 399  DFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCV 458
            D C E      N IC N      C C  GF         CED+DEC      C++N  C+
Sbjct: 1723 DECGEIPAICANGICINQIGSFRCECPAGFN-YNSILLACEDVDECGSRESPCQQNADCI 1781

Query: 459  NTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNG 518
            N PGS+ C C  GY      +C   +EC    + C     C +T G + C+C  G+  + 
Sbjct: 1782 NIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGD-CMDTEGSYMCLCHRGFQASA 1840

Query: 519  TTCKAFCKDGCR----NGGAC---IAANVCACPQGF--TGPSCETDIDECSDGFVQCDSR 569
                    D C       G C   I +  C C  GF  T      D DEC+    Q    
Sbjct: 1841 DQTLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRF 1900

Query: 570  ANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCR 629
             +C+N  G +HC C+DG+      +  G++C D +EC +   +C   T C NL+G + C 
Sbjct: 1901 GHCLNTAGSFHCLCQDGFE----LTADGKNCVDTNECLSLAGTCLPGT-CQNLEGSFRCI 1955

Query: 630  CPHGKNCTGD-CIHDGKVKHNGQIWVL----ENDRCSVCSCQNGFVM 671
            CP G     D CI   +      + +      +     C C  GFV+
Sbjct: 1956 CPPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVL 2002



 Score =  119 bits (299), Expect = 9e-27
 Identities = 123/513 (23%), Positives = 185/513 (36%), Gaps = 108/513 (21%)

Query: 343  EGERNTVYSSSGVCV----LYECKDQTMKLVESSGCPALDCPESHQITLSHSC------- 391
            E   N    ++GVCV     + C+      ++ +G   ++C ++ + ++ H C       
Sbjct: 2087 ECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTG---INCVDTDECSVGHPCGQGTCTN 2143

Query: 392  ------CKVCKGYD-----FCSERHNCMENSI-----CRNLNDRAVCSCRDGFRALREDN 435
                  C    G++      C +   C  N +     C N     +C+C  G+  LRED 
Sbjct: 2144 VIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGY-TLREDG 2202

Query: 436  AYCEDIDECAEGRHYCRENTM-CVNTPGSFMCICKTGYIRI--DDYSCTEHDECITNQHN 492
            A C D+DECA+G+  C    M C N  G+F C+C  G   +      CT+ +EC      
Sbjct: 2203 AMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDL 2262

Query: 493  CDENALCFNTVGGHNCVCKPGYTGNGT---------------TCKAFCKDGCRNGGACIA 537
            C  N  C NT G   C C  G+  + T                 +  C+    +  A   
Sbjct: 2263 C-VNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTR 2321

Query: 538  ANVCACPQGFTGPSCE------------------------TDIDECSDGFVQCDSRANCI 573
            A  C       GP CE                         D+DEC      C +   CI
Sbjct: 2322 AECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLC-AHGECI 2380

Query: 574  NLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPH- 632
            N  G + C C+ GY  +     +  +C D+DEC      C    +C N  G + C CP  
Sbjct: 2381 NSLGSFRCHCQAGYTPDA----TATTCLDMDECSQVPKPCT--FLCKNTKGSFLCSCPRG 2434

Query: 633  ------GKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDL 686
                  G+ C  D       +HN Q   +       C C  GF    +   D +  +   
Sbjct: 2435 YLLEEDGRTCK-DLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQP 2493

Query: 687  FCC---PECDPRLSS-QCLHQNGETLYNSGDTWVQNCQQC----RC---LQGEVDCWPLP 735
              C     C     S +C    G TL +SG    ++  +C    RC    Q ++  +   
Sbjct: 2494 GPCGAHGHCHNTPGSFRCECHQGFTLVSSGH-GCEDVNECDGPHRCQHGCQNQLGGYRCS 2552

Query: 736  CPDVECEFS----ILPENECC---PRCVTDPCQ 761
            CP    + S     + ENEC    P C +  C+
Sbjct: 2553 CPQGFTQHSQWAQCVDENECALSPPTCGSASCR 2585



 Score =  112 bits (279), Expect = 2e-24
 Identities = 126/485 (25%), Positives = 177/485 (36%), Gaps = 109/485 (22%)

Query: 379  CPESHQITLSHSCCKVCK-GYDFCSERHNCMENS------------ICRNLNDRAVCSCR 425
            C   H +  + S   +C+ G++  ++  NC++ +             C+NL     C C 
Sbjct: 1898 CRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICP 1957

Query: 426  DGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDD-YSC--TE 482
             GF+   +   +C DIDEC+E  + C   T C N+PGSF C+C  G++  D+ + C  T 
Sbjct: 1958 PGFQVQSD---HCIDIDECSEEPNLCLFGT-CTNSPGSFQCLCPPGFVLSDNGHRCFDTR 2013

Query: 483  HDECITN-QHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDG------------- 528
               C T  +         FNT     C  K    G G  C+   ++G             
Sbjct: 2014 QSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHG 2073

Query: 529  ---------------CRNGGAC---IAANV-----CACPQG----FTGPSCETDIDECSD 561
                             N G C   +  N      C CP G    FTG +C  D DECS 
Sbjct: 2074 AVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINC-VDTDECSV 2132

Query: 562  GFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFN 621
            G   C  +  C N+ G + C C DG+    M      +CEDIDEC      CA    C N
Sbjct: 2133 GH-PC-GQGTCTNVIGGFECACADGFEPGLMM-----TCEDIDECSLNPLLCA--FRCHN 2183

Query: 622  LDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCEN 681
             +G Y C CP G         DG +  +            V  C +G   C     +C+N
Sbjct: 2184 TEGSYLCTCPAGYTLR----EDGAMCRD------------VDECADGQQDCHARGMECKN 2227

Query: 682  PTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQN--CQQCRCLQ--GEVDCWPLPCP 737
              +  F C  C P +  + L  +GE   +  +   Q   C   RC+   G   C      
Sbjct: 2228 -LIGTFAC-VCPPGM--RPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRC------ 2277

Query: 738  DVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFT-----GSSWIKHGT 792
            D +  F   P    C      PC A+ ++            V R       G  W   G 
Sbjct: 2278 DCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGW---GP 2334

Query: 793  ECTLC 797
             C LC
Sbjct: 2335 RCELC 2339



 Score =  109 bits (273), Expect = 9e-24
 Identities = 119/467 (25%), Positives = 169/467 (36%), Gaps = 107/467 (22%)

Query: 288  IDGCKNCTCLNGTI----QCETL---ICPNPDCPLKSALAYVDGKCCKECKSICQFQGRT 340
            I G  +C CL G +    +C  L   +     C  +     V G     C+    F G  
Sbjct: 1300 IPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQ--GFAGDG 1357

Query: 341  YFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDF 400
            +F  +R+    +  +C   +C       + + G    +C      T  H   + C+  D 
Sbjct: 1358 FFCEDRDECAENVDLCDNGQC-------LNAPGGYRCECEMGFDPTEDH---RACQDVDE 1407

Query: 401  CSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNT 460
            C++ + C   S C NL     C C  G+  L      C DI+ECA+  +    N +C+NT
Sbjct: 1408 CAQGNLCAFGS-CENLPGMFRCICNGGYE-LDRGGGNCTDINECADPVNCI--NGVCINT 1463

Query: 461  PGSFMCICKTGY-IRIDDYSC--TEHDECITNQHNCDENAL-CFNTVG----GHNCVCKP 512
            PGS++C C   + +      C  T    C    H+  ++ + C   +G      +C C  
Sbjct: 1464 PGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSL 1523

Query: 513  GYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCET----DIDECSDGFVQCDS 568
            G    G  C+      C          +C   +GF  P+  T    DIDEC +    C  
Sbjct: 1524 GRAW-GNPCEL-----CPMANTTEYRTLCPGGEGFQ-PNRITVILEDIDECQELPGLCQG 1576

Query: 569  RANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC 628
              +C+N  G + CEC  GYH     S     CEDIDEC T    C   T C+N  G Y C
Sbjct: 1577 -GDCVNTFGSFQCECPPGYH----LSEHTRICEDIDECSTHSGICGPGT-CYNTLGNYTC 1630

Query: 629  RCP-------HGKNCTGDCIHDGKVKHNGQIWVLENDRCSVC------SCQNGFVMCRRM 675
             CP        G NC                    + R SVC      +CQN        
Sbjct: 1631 VCPAEYLQVNGGNNCM-------------------DMRKSVCFRHYNGTCQNELAF---- 1667

Query: 676  VCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQC 722
                 N T  + CC                   YN G  W + C+ C
Sbjct: 1668 -----NVTRKMCCCS------------------YNIGQAWNRPCEAC 1691



 Score =  103 bits (258), Expect = 5e-22
 Identities = 126/480 (26%), Positives = 175/480 (36%), Gaps = 129/480 (26%)

Query: 352 SSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENS 411
           S G+C L  C       V + G     C    +++      K C  ++ C+    C+ N 
Sbjct: 496 SGGLCHLGRC-------VNTEGSFQCVCNAGFELSPDG---KNCVDHNECATSTMCV-NG 544

Query: 412 ICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTG 471
           +C N +    C C+ GF  L     YC DIDEC +    C  N  C NT GSF C C  G
Sbjct: 545 VCLNEDGSFSCLCKPGF-LLAPGGHYCMDIDEC-QTPGIC-VNGHCTNTEGSFRCQCLGG 601

Query: 472 -------------YIRIDDYSCTEHDEC-------ITNQHNCDENALCFNTVGGHNCVCK 511
                        ++R   Y   E   C       +T    C     C N   G    C+
Sbjct: 602 LAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECC-----CANPDHGFGEPCQ 656

Query: 512 PGYTGNGTTCKAFCKDG-------------------CRNGGACIAANV-----CACPQGF 547
                +    +A C  G                   C NG   +  N+     C C  G+
Sbjct: 657 LCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANG---VCENLRGSYRCVCNLGY 713

Query: 548 ----TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDI 603
               +G  C TD+DEC+   + CD+   C N PG Y C C  G+H    F    E C+D+
Sbjct: 714 EAGASGKDC-TDVDECALNSLLCDN-GWCQNSPGSYSCSCPPGFH----FWQDTEICKDV 767

Query: 604 DECGTGRHSCANDTICFNLDGGYDCRC-------PHGKNC----TGDC---IHDGKVKHN 649
           DEC +    C +  +C NL G Y C+C       P G  C     G C   I + + + N
Sbjct: 768 DECLSS--PCVSG-VCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVN 824

Query: 650 --------------GQIWVLENDRCSV-CSCQNGFVMCRRMVCDCENPTVDLFCCPECDP 694
                         G  W    +RC +  +C  GF     + CD  N         EC+ 
Sbjct: 825 LQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVN---------ECE- 874

Query: 695 RLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQG-EVDCWPLPCPDVECE--FSILPENEC 751
             S   +  NG  +  +G        +C C +G  +D     C DV  E  F    E+EC
Sbjct: 875 --SFPGVCPNGRCVNTAGSF------RCECPEGLMLDASGRLCVDVRLEPCFLRWDEDEC 926



 Score =  103 bits (258), Expect = 5e-22
 Identities = 82/282 (29%), Positives = 108/282 (38%), Gaps = 41/282 (14%)

Query: 395  CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
            C G + C E  N   +  C +     +C C  GF+A   D   C DIDEC   R  C   
Sbjct: 1803 CVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQA-SADQTLCMDIDEC--DRQPCGNG 1859

Query: 455  TMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGY 514
            T C N  GS+ C+C  G++   +  C + DEC T          C NT G  +C+C+ G+
Sbjct: 1860 T-CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGF 1918

Query: 515  --TGNGTTCKAFCKDGCRNGGACIAANV--------CACPQGFTGPSCE-TDIDECSDGF 563
              T +G  C     +     G C+            C CP GF   S    DIDECS+  
Sbjct: 1919 ELTADGKNC-VDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEP 1977

Query: 564  VQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLD 623
              C     C N PG + C C  G+    + S +G  C D              + CF   
Sbjct: 1978 NLC-LFGTCTNSPGSFQCLCPPGF----VLSDNGHRCFD-----------TRQSFCFTRF 2021

Query: 624  GGYDCRCPHGKNCTGD--CIHDGKVKHNGQIWVLENDRCSVC 663
                C  P   N T    C      K  G+ W    D C +C
Sbjct: 2022 EAGKCSVPKAFNTTKTRCCCS----KRPGEGW---GDPCELC 2056



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 89/312 (28%), Positives = 122/312 (39%), Gaps = 68/312 (21%)

Query: 374 CPALDCPESHQITLSHSCCKVCKGYDF--CSERHNCMENSICRNLNDRAVCSCRDGFRAL 431
           CPA D  E  Q   S        G D   C+       N +C NL     C C  G+ A 
Sbjct: 658 CPAKDSAE-FQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEA- 715

Query: 432 REDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQ 490
                 C D+DECA     C +N  C N+PGS+ C C  G+    D   C + DEC+++ 
Sbjct: 716 GASGKDCTDVDECALNSLLC-DNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSP 774

Query: 491 HNCDENALCFNTVGGHNCVCKPG--YTGNGTTCKAFCKDGC-----------RNGGACIA 537
             C  + +C N  G + C C PG     +GT C    K  C              GA + 
Sbjct: 775 --C-VSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLR 831

Query: 538 ANVC------------------ACPQGF---TGPSCETDIDECSDGFVQCDSRANCINLP 576
           +  C                  AC +GF   TG +C+ D++EC + F        C+N  
Sbjct: 832 SECCATLGAAWGSPCERCEIDPACARGFARMTGVTCD-DVNEC-ESFPGVCPNGRCVNTA 889

Query: 577 GWYHCECRDGYHDNGMFSPSGESCEDI-----------DECGT---GRHSCANDTICFNL 622
           G + CEC +G     M   SG  C D+           DECG    G++    D  C ++
Sbjct: 890 GSFRCECPEGL----MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRM--DVCCCSI 943

Query: 623 DG--GYDCR-CP 631
               G +C  CP
Sbjct: 944 GAVWGVECEACP 955



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 65/209 (31%), Positives = 91/209 (43%), Gaps = 28/209 (13%)

Query: 439 EDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQ-HNCDENA 497
           + ID C    + C  N  C+ TP S+ C C  GY +     C + DEC ++  H+ D   
Sbjct: 407 QTIDICRHFTNLCL-NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGD--- 462

Query: 498 LCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGC-RNGGACIAANV--------CACPQGF- 547
            C N  G ++C C PG+    T       D C  +GG C             C C  GF 
Sbjct: 463 -CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFE 521

Query: 548 ---TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDID 604
               G +C  D +EC+     C +   C+N  G + C C+ G+    + +P G  C DID
Sbjct: 522 LSPDGKNC-VDHNECATS-TMCVNGV-CLNEDGSFSCLCKPGF----LLAPGGHYCMDID 574

Query: 605 ECGTGRHSCANDTICFNLDGGYDCRCPHG 633
           EC T    C N   C N +G + C+C  G
Sbjct: 575 ECQT-PGICVNGH-CTNTEGSFRCQCLGG 601



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 74/264 (28%), Positives = 103/264 (39%), Gaps = 37/264 (14%)

Query: 385  ITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDEC 444
            +T +  CC + + +      + C    +      R +C   +GF+  R      EDIDEC
Sbjct: 1514 VTRASCCCSLGRAWG-----NPCELCPMANTTEYRTLCPGGEGFQPNRI-TVILEDIDEC 1567

Query: 445  AEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYS--CTEHDECITNQHNCDENALCFNT 502
             E    C+    CVNT GSF C C  GY  + +++  C + DEC T+   C     C+NT
Sbjct: 1568 QELPGLCQGGD-CVNTFGSFQCECPPGY-HLSEHTRICEDIDECSTHSGICGPGT-CYNT 1624

Query: 503  VGGHNCVCKPGY--TGNGTTCKAFCKDGC--RNGGAC-------IAANVCACPQGFTGPS 551
            +G + CVC   Y     G  C    K  C     G C       +   +C C     G +
Sbjct: 1625 LGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI-GQA 1683

Query: 552  CETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRH 611
                 + C    +  D +  C N    +  +   G               DIDECG    
Sbjct: 1684 WNRPCEACPTP-ISPDYQILCGNQAPGFLTDIHTG------------KPLDIDECGEIPA 1730

Query: 612  SCANDTICFNLDGGYDCRCPHGKN 635
             CAN  IC N  G + C CP G N
Sbjct: 1731 ICANG-ICINQIGSFRCECPAGFN 1753



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 75/290 (25%), Positives = 103/290 (35%), Gaps = 72/290 (24%)

Query: 444 CAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTV 503
           C EG  +C +  +C    G+    C                  ++    C  + +   T 
Sbjct: 90  CGEG--FCSQPNLCTCADGTLAPSCG-----------------VSRGSGCSVSCMNGGTC 130

Query: 504 GGHNCVCKPGYTGNGTTC-KAFCKDGCRNGGACIAANVCACPQGFTGPSCETDI------ 556
            G +C+C+ GYTG  T C +  C  GC NGG CI  N CAC  GF GP CE D       
Sbjct: 131 RGASCLCQKGYTG--TVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCF 188

Query: 557 -----DECSDGF--VQCDSRANCINLP-GW-YHCE--------CRDGYHDNGMFSPSGES 599
                + C      + C     C  +   W   CE        CR G+  N        +
Sbjct: 189 GQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTG----A 244

Query: 600 CEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDR 659
           C+D+DEC      C   + C N+ G + CRCP G   +         +      VL   R
Sbjct: 245 CQDVDECQAVPGLCQGGS-CVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGR 303

Query: 660 CS----------VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQ 699
           C+           C C  G        C    P  +L     C PR S++
Sbjct: 304 CAGDLAGHYTRRQCCCDRG-------RCWAAGPVPEL-----CPPRGSNE 341



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 84/339 (24%), Positives = 115/339 (33%), Gaps = 76/339 (22%)

Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEH 483
           CR GF       A C+D+DEC      C+  + CVN  GSF C C  G+ R+ D S    
Sbjct: 232 CRRGFIPNIHTGA-CQDVDECQAVPGLCQGGS-CVNMVGSFHCRCPVGH-RLSDSSAACE 288

Query: 484 DECITNQHNCDENALCFNTVGGH----NCVCK---------------------------- 511
           D       +      C   + GH     C C                             
Sbjct: 289 DYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQ 348

Query: 512 -----PGYTGNGTTCKAFCKDGCR--------NGGACIAANVCACPQGFTGPSCET---D 555
                PG+ G       F  +G          N     A  + +   G +     T    
Sbjct: 349 RLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQT 408

Query: 556 IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCAN 615
           ID C   F        C+  P  Y CEC  GY  +      GE C D+DEC +   S  +
Sbjct: 409 IDICRH-FTNLCLNGRCLPTPSSYRCECNVGYTQD----VRGE-CIDVDECTS---SPCH 459

Query: 616 DTICFNLDGGYDCRCPHGKNCT---------GDCIHDGKVKHNGQIWVLENDRCSVCSCQ 666
              C N+ G Y CRC  G   T          +CI  G + H G+   +  +    C C 
Sbjct: 460 HGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGR--CVNTEGSFQCVCN 517

Query: 667 NGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNG 705
            GF     +  D +N  VD   C      ++  CL+++G
Sbjct: 518 AGF----ELSPDGKN-CVDHNECATSTMCVNGVCLNEDG 551



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 64/258 (24%), Positives = 86/258 (33%), Gaps = 77/258 (29%)

Query: 389 HSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCS------CRDGFRALREDNAYCEDID 442
           H+ C  C G+     R  C+   ICR       CS      C DG  A            
Sbjct: 65  HAYC--CPGWRTFPGRSQCVV-PICRRACGEGFCSQPNLCTCADGTLA-----------P 110

Query: 443 ECAEGRHY-CRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFN 501
            C   R   C  + M   T     C+C+ GY              +  Q  CD    C N
Sbjct: 111 SCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGT-----------VCGQPICDRG--CHN 157

Query: 502 ---TVGGHNCVCKPGYTG--------NGTTCKAFCKDGCRN---GGACIAANVCA----- 542
               +G + C C  G+ G         G        +GC++   G  C  A  CA     
Sbjct: 158 GGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRA 217

Query: 543 --------------CPQGFTGPSCET----DIDECSDGFVQCDSRANCINLPGWYHCECR 584
                         C +GF  P+  T    D+DEC      C    +C+N+ G +HC C 
Sbjct: 218 WGLPCELCPAQPHPCRRGFI-PNIHTGACQDVDECQAVPGLCQG-GSCVNMVGSFHCRCP 275

Query: 585 DGYHDNGMFSPSGESCED 602
            G+      S S  +CED
Sbjct: 276 VGHR----LSDSSAACED 289


>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
          Length = 1231

 Score =  155 bits (393), Expect = 1e-37
 Identities = 123/420 (29%), Positives = 164/420 (39%), Gaps = 60/420 (14%)

Query: 401  CSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNT 460
            C +   C +  +C  +   A+CSC  G+ A+  D   CED DEC  G H C     CVNT
Sbjct: 683  CKDNGPCKQ--VCSTVGGSAICSCFPGY-AIMADGVSCEDQDECLMGAHDCSRRQFCVNT 739

Query: 461  PGSFMCI-----CKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNC----VCK 511
             GSF C+     C  GYI      C + +EC+T+ H C     C NT+G  +C     C+
Sbjct: 740  LGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCE 799

Query: 512  PGYTGNGTTCKAF---------CKDG--CRNG-GACIAANVCACPQGFTGP---SCETDI 556
            PGY      C+           C+ G  C+N  G+        C  GF      +C  DI
Sbjct: 800  PGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNC-VDI 858

Query: 557  DECSDGFVQCDSRANCINLPGWYHCE-----CRDGYHDNGMFSPSGESCEDIDECGTGRH 611
            +EC+     C    +CIN  G Y C+     C  GYH     S  G  C D++EC TG H
Sbjct: 859  NECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHA----SDDGTKCVDVNECETGVH 914

Query: 612  SCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS---------- 661
             C    +C NL G Y C C  G     D    G +  N + W      C           
Sbjct: 915  RCGEGQVCHNLPGSYRCDCKAG--FQRDAFGRGCIDVN-ECWASPGRLCQHTCENTLGSY 971

Query: 662  VCSCQNGFVMCR-RMVCDCENPTVDLFCCPECDPRLSS-QCLHQNGETLYNSGDTW--VQ 717
             CSC +GF++      C+  N      C  EC     S QC  + G  L   G T   + 
Sbjct: 972  RCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDID 1031

Query: 718  NCQQCRCLQGEVDCWPLP----CPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTC 773
             C Q   +     C  +P    C   E  +++      C     D C   T      +TC
Sbjct: 1032 ECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKD--VDECALGTHNCSEAETC 1089



 Score =  136 bits (343), Expect = 7e-32
 Identities = 93/303 (30%), Positives = 134/303 (44%), Gaps = 76/303 (25%)

Query: 388  SHSC-----CKVCKGYDFCSERHNCMENSI------CRNLNDRAVCS--CRDGFRALR-- 432
            +H+C     C+  KG  +C  R  CM+  +      C ++N+    S  CR GF  +   
Sbjct: 819  THTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTV 878

Query: 433  -------------------EDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYI 473
                               +D   C D++EC  G H C E  +C N PGS+ C CK G+ 
Sbjct: 879  GSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQ 938

Query: 474  RIDDY--SCTEHDECITN-----QHNCDENALCFNTVGGHNCVCKPGY--TGNGTTCKAF 524
            R D +   C + +EC  +     QH C+      NT+G + C C  G+    +G  C+  
Sbjct: 939  R-DAFGRGCIDVNECWASPGRLCQHTCE------NTLGSYRCSCASGFLLAADGKRCEDV 991

Query: 525  -------CKDGCRNGGACIAANVCACPQGF----TGPSCETDIDECSDGF-VQCDSRANC 572
                   C   C N      +  C C QG+     G +C TDIDEC+ G  + C  R  C
Sbjct: 992  NECEAQRCSQECAN---IYGSYQCYCRQGYQLAEDGHTC-TDIDECAQGAGILCTFR--C 1045

Query: 573  INLPGWYHCEC-RDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC--- 628
            +N+PG Y C C   GY      + +G SC+D+DEC  G H+C+    C N+ G + C   
Sbjct: 1046 LNVPGSYQCACPEQGY----TMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRF 1101

Query: 629  RCP 631
             CP
Sbjct: 1102 ECP 1104



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 110/416 (26%), Positives = 160/416 (38%), Gaps = 72/416 (17%)

Query: 439 EDIDECAE-GRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENA 497
           +D DEC       C+   +C+NT GS+ C C  G+   DD      +          E A
Sbjct: 603 DDQDECLLLPGELCQH--LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPA 660

Query: 498 LC--FNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFT----GPS 551
           L   F+ V   N +  P    N       CK  C   G    + +C+C  G+     G S
Sbjct: 661 LKSEFSQVAS-NTIPLPLPQPNTCKDNGPCKQVCSTVG---GSAICSCFPGYAIMADGVS 716

Query: 552 CETDIDECSDGFVQCDSRANCINLPGWYHCE-----CRDGYHDNGMFSPSGESCEDIDEC 606
           CE D DEC  G   C  R  C+N  G ++C      C DGY  N     +   C DI+EC
Sbjct: 717 CE-DQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILN-----AHRKCVDINEC 770

Query: 607 GTGRHSCANDTICFNLDGGYDCRCPHGKNC-TGDCIHDGKVKHNGQIWVLENDRCSV--C 663
            T  H+C+    C N  G +   C     C  G  + DG+ +        + D C++   
Sbjct: 771 VTDLHTCSRGEHCVNTLGSF--HCYKALTCEPGYALKDGECE--------DVDECAMGTH 820

Query: 664 SCQNGFVMCR----------RMVC------DCENPTVDLFCCPECDPRLSSQCLHQNGET 707
           +CQ GF +C+          R  C      D E   VD+  C      LS  C  + G +
Sbjct: 821 TCQPGF-LCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTS----LSEPC--RPGFS 873

Query: 708 LYNSGDTWVQNCQQCRCLQG-EVDCWPLPCPDV-ECEFSI--LPENECC---PRCVTDPC 760
             N+  ++        C +G         C DV ECE  +    E + C   P      C
Sbjct: 874 CINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDC 933

Query: 761 QADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTL----CQCKNGHICCSVDPQC 812
           +A   R+   + C+D +N    +     +H  E TL    C C +G +  +   +C
Sbjct: 934 KAGFQRDAFGRGCID-VNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRC 988



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 41/156 (26%), Positives = 63/156 (40%), Gaps = 16/156 (10%)

Query: 356  CVLYECKDQTMKLVESSGCPALDCPESHQITLS-HSCCKVCKGYDFCSERHNCMENSICR 414
            C    C  +   +  S  C    C + +Q+    H+C  +    D C++    +    C 
Sbjct: 994  CEAQRCSQECANIYGSYQCY---CRQGYQLAEDGHTCTDI----DECAQGAGILCTFRCL 1046

Query: 415  NLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCI---CKTG 471
            N+     C+C +    +  +   C+D+DECA G H C E   C N  GSF C+   C   
Sbjct: 1047 NVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPN 1106

Query: 472  YIRIDDYSC---TEHD--ECITNQHNCDENALCFNT 502
            Y+++    C   T HD  EC  +        L F T
Sbjct: 1107 YVQVSKTKCERTTCHDFLECQNSPARITHYQLNFQT 1142



 Score = 34.7 bits (78), Expect = 0.37
 Identities = 30/110 (27%), Positives = 47/110 (42%), Gaps = 19/110 (17%)

Query: 639 DCIHDGKVKHN---GQIWVLENDRCSVCSCQNG-------FVMCRRMVCDCENPTVDLFC 688
           DC+  G V+     GQ + ++      CSC  G       F++C  +  +C    V    
Sbjct: 72  DCLQGGFVRGRVPAGQSYFVDFGSTE-CSCPPGGGKISCQFMLCPELPPNCIEAVVVADS 130

Query: 689 CPECDPRLSSQCLHQNGETLYNSGDT-WVQNCQQCRC--LQGEVDCWPLP 735
           CP+C       C+H   +  Y +G T  +  C+ C C    GE+ C+ LP
Sbjct: 131 CPQCG---QVGCVHAGHK--YAAGHTVHLPPCRACHCPDAGGELICYQLP 175


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score =  154 bits (390), Expect = 2e-37
 Identities = 147/529 (27%), Positives = 209/529 (39%), Gaps = 100/529 (18%)

Query: 288 IDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGER- 346
           +D C    CLNG    + +   N  CP +       G+ C E    CQ Q      G   
Sbjct: 237 VDDCPGHRCLNGGTCVDGVNTYNCQCPPEWT-----GQFCTEDVDECQLQPNACHNGGTC 291

Query: 347 -NTVYSSSGVCVLYECKDQTMKLVESSGCPALDC---PESHQITLSHSCC-------KVC 395
            NT+   S VCV     +   + ++   C    C      H    S  C         +C
Sbjct: 292 FNTLGGHSCVCVNGWTGESCSQNIDD--CATAVCFHGATCHDRVASFYCACPMGKTGLLC 349

Query: 396 KGYDFCSERHNCMENSIC--RNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRE 453
              D C   + C E++IC    +N RA+C+C  GF       A  +D+DEC+ G + C  
Sbjct: 350 HLDDACVS-NPCHEDAICDTNPVNGRAICTCPPGFTG----GACDQDVDECSIGANPCEH 404

Query: 454 NTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPG 513
              CVNT GSF+C C  GY        T+ +EC++    C   A C + +G   C+C  G
Sbjct: 405 LGRCVNTQGSFLCQCGRGY--TGPRCETDVNECLSGP--CRNQATCLDRIGQFTCICMAG 460

Query: 514 YTGNGTTCKA---FCKDG-CRNGGAC---IAANVCACPQGFTGPSCETDIDECSDGFVQC 566
           +T  GT C+     C+   C NGG C   +    C CP GF+G +C+ D+DEC+     C
Sbjct: 461 FT--GTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECAS--TPC 516

Query: 567 DSRANCINLPGWYHCECRDGYHD---------------------NGMFSPS--------G 597
            + A C++ P  Y C C +G+                       +G+ S S        G
Sbjct: 517 RNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTG 576

Query: 598 ESCE-DIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLE 656
             CE  +DEC +    C +   C +L   Y CRCP G   TG       V     I    
Sbjct: 577 TRCESQVDECRS--QPCRHGGKCLDLVDKYLCRCPSG--TTG-------VNCEVNIDDCA 625

Query: 657 NDRCSVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWV 716
           ++ C+   C++G     R  C C+       C  E +   SS C           G + V
Sbjct: 626 SNPCTFGVCRDGI---NRYDCVCQPGFTGPLCNVEINECASSPC---------GEGGSCV 673

Query: 717 --QNCQQCRCLQGEVD--CWP--LPCPDVECEFSILPENECCPRCVTDP 759
             +N  +C C  G +   C P   PC    C   I  +     RCV +P
Sbjct: 674 DGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEP 722



 Score =  139 bits (351), Expect = 8e-33
 Identities = 125/464 (26%), Positives = 175/464 (37%), Gaps = 126/464 (27%)

Query: 407 CMENSICRNLNDRAV-CSCRDGFRALREDNAYCE-DIDECAEGRHYCRENTMCVNTPGSF 464
           C     CR   D    C+C  GF     +   CE ++D+C    H C     CV+   ++
Sbjct: 206 CRNGGTCRQSGDLTYDCACLPGF-----EGQNCEVNVDDCPG--HRCLNGGTCVDGVNTY 258

Query: 465 MCICKTGYIRIDDYSCTEH-DECITNQHNCDENALCFNTVGGHNCVCKPGYTG------- 516
            C C   +       CTE  DEC    + C     CFNT+GGH+CVC  G+TG       
Sbjct: 259 NCQCPPEWT---GQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNI 315

Query: 517 ---------NGTTC-----KAFC-----KDG--CRNGGACIA----------------AN 539
                    +G TC       +C     K G  C    AC++                  
Sbjct: 316 DDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRA 375

Query: 540 VCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGES 599
           +C CP GFTG +C+ D+DECS G   C+    C+N  G + C+C  GY        +G  
Sbjct: 376 ICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY--------TGPR 427

Query: 600 CE-DIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLEND 658
           CE D++EC +G   C N   C +  G + C C  G                G    ++ D
Sbjct: 428 CETDVNECLSG--PCRNQATCLDRIGQFTCICMAG--------------FTGTYCEVDID 471

Query: 659 RCSVCSCQNGFVMCRRMV----CDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDT 714
            C    C NG V C+  V    C C +      C  + D   S+ C  +NG    +  D 
Sbjct: 472 ECQSSPCVNGGV-CKDRVNGFSCTCPSGFSGSTCQLDVDECASTPC--RNGAKCVDQPDG 528

Query: 715 WVQNCQQCRCLQG---------EVDCWPLPCPDVECEFSILPEN-ECCPRCVTDPCQADT 764
           +     +CRC +G           DC P PC    C   I   +  C P      C++  
Sbjct: 529 Y-----ECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQ- 582

Query: 765 IRNDITKTCLDEMNVVRFTGSSWIKHGTECT------LCQCKNG 802
                    +DE        S   +HG +C       LC+C +G
Sbjct: 583 ---------VDECR------SQPCRHGGKCLDLVDKYLCRCPSG 611



 Score =  114 bits (284), Expect = 5e-25
 Identities = 138/561 (24%), Positives = 194/561 (34%), Gaps = 154/561 (27%)

Query: 262 MNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLI------CPN----- 310
           ++R+ Q  C     M G T    E  ID C++  C+NG + C+  +      CP+     
Sbjct: 447 LDRIGQFTC---ICMAGFTGTYCEVDIDECQSSPCVNGGV-CKDRVNGFSCTCPSGFSGS 502

Query: 311 ------PDC---PLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYEC 361
                  +C   P ++    VD     EC+    F+G      +RN    S   C    C
Sbjct: 503 TCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLC---DRNVDDCSPDPCHHGRC 559

Query: 362 KD--QTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSE----------RHNCME 409
            D   +     + G     C        S  C    K  D   +            NC  
Sbjct: 560 VDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEV 619

Query: 410 N-----------SICRNLNDRAVCSCRDGFRALREDNAYCE-DIDECAEGRHYCRENTMC 457
           N            +CR+  +R  C C+ GF         C  +I+ECA     C E   C
Sbjct: 620 NIDDCASNPCTFGVCRDGINRYDCVCQPGF-----TGPLCNVEINECASSP--CGEGGSC 672

Query: 458 VNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCD----ENALCFNTVGGHNCVCKPG 513
           V+    F C+C  G +            C+   H C      + +C++  GG  CVC+PG
Sbjct: 673 VDGENGFRCLCPPGSL---------PPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPG 723

Query: 514 YTG------------------NGTTCKA-------FCKDG----------------CRNG 532
           ++G                   G TC +        C  G                C +G
Sbjct: 724 WSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHG 783

Query: 533 GACIAA----NVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYH 588
           G C +A     VC+CPQG+ GP C+ D+DEC+ G   C     C NL G + C C  GY 
Sbjct: 784 GRCESAPGQLPVCSCPQGWQGPRCQQDVDECA-GPAPCGPHGICTNLAGSFSCTCHGGY- 841

Query: 589 DNGMFSPSGESC-EDIDECGTGRHSCANDTICFNLDGGYDCRCP---HGKNCTGD---CI 641
                  +G SC +DI++C    + C N   C +  G + C C     G  C  D   C+
Sbjct: 842 -------TGPSCDQDINDCDP--NPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECL 892

Query: 642 HDG-----------------KVKHNGQIWVLENDRCSVCSCQNGFVM---CRRMVCDCEN 681
            +                     + G     +   CS  SC NG           C C  
Sbjct: 893 SNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRP 952

Query: 682 PTVDLFCCPECDPRLSSQCLH 702
                 C  E DP LS  CLH
Sbjct: 953 GYTGAHCQHEADPCLSRPCLH 973



 Score =  102 bits (254), Expect = 1e-21
 Identities = 100/346 (28%), Positives = 132/346 (38%), Gaps = 75/346 (21%)

Query: 407  CMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMC 466
            C+    C++      CSC  GF   R       D+DEC      C   T C +   SF C
Sbjct: 858  CLNGGSCQDGVGSFSCSCLPGFAGPR----CARDVDECLSNP--CGPGT-CTDHVASFTC 910

Query: 467  ICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKA--F 524
             C  GY     + C E D    +  +C     C + V   +C+C+PGYTG     +A   
Sbjct: 911  TCPPGY---GGFHC-EQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPC 966

Query: 525  CKDGCRNGGACIAANV---CACPQGFTGPSCETDIDECSDGFVQCDSR-----ANCINLP 576
                C +GG C AA+    C C + FTGP C+T +D CS    Q   R     A C+  P
Sbjct: 967  LSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPP 1026

Query: 577  GWYH--CE-----CRDGYHDNGM----FSPSGESCEDID--------ECGTGRH------ 611
            GW    C+     CR+     G+       +G  C D D        E  TG H      
Sbjct: 1027 GWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVD 1086

Query: 612  -----SCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQ 666
                  C +   C    GGY C C  G N  GD   D            + D C+   CQ
Sbjct: 1087 PCLAQPCQHGGTCRGYMGGYMCECLPGYN--GDNCED------------DVDECASQPCQ 1132

Query: 667  NG---FVMCRRMVCDCENPTVDLFCCPECD-----PRLSS--QCLH 702
            +G     +  R +C C   T+ + C    D     P L S  +CLH
Sbjct: 1133 HGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLH 1178



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 90/348 (25%), Positives = 128/348 (36%), Gaps = 70/348 (20%)

Query: 421  VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC 480
            VCSC  G++  R      +D+DECA G   C  + +C N  GSF C C  GY      SC
Sbjct: 795  VCSCPQGWQGPRCQ----QDVDECA-GPAPCGPHGICTNLAGSFSCTCHGGY---TGPSC 846

Query: 481  TEH-DECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKA-FCKDGCRNGGAC--- 535
             +  ++C  N   C     C + VG  +C C PG+ G         C       G C   
Sbjct: 847  DQDINDCDPNP--CLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDH 904

Query: 536  IAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSP 595
            +A+  C CP G+ G  CE D+ +CS     C +   C++    + C CR GY        
Sbjct: 905  VASFTCTCPPGYGGFHCEQDLPDCSPS--SCFNGGTCVDGVNSFSCLCRPGY-------- 954

Query: 596  SGESCE-DIDECGTGRHSCANDTICFNLDGGYDCRCPH---GKNCT-------------- 637
            +G  C+ + D C +    C +  +C     G+ C C     G  C               
Sbjct: 955  TGAHCQHEADPCLS--RPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNG 1012

Query: 638  GDCIHDGKV-----KHNGQIWVLENDRCSVCSCQNGF---VMCR----------RMVCDC 679
            G C+  G         +G++  + +  C   + Q G     +C+             C C
Sbjct: 1013 GRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVC 1072

Query: 680  ENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQG 727
                    C  E DP L+  C H      Y  G         C CL G
Sbjct: 1073 PEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGG-------YMCECLPG 1113



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 101/417 (24%), Positives = 137/417 (32%), Gaps = 115/417 (27%)

Query: 407  CMENSICRNLNDRAVCSCRDGFRALREDNAYCED-IDECAEGRHYCRENTMCVNTPGSFM 465
            C     CR      +C C  G+     DN  CED +DECA     C+    C++    ++
Sbjct: 1093 CQHGGTCRGYMGGYMCECLPGYNG---DN--CEDDVDECAS--QPCQHGGSCIDLVARYL 1145

Query: 466  CICKTGYIRIDDYSCT-EHDEC-----ITNQHNCDENALCFNTVGGHNCVCKPGYTGNGT 519
            C C  G + +    C    D+C     + +   C  N  C + VGG  C C PGYTG   
Sbjct: 1146 CSCPPGTLGV---LCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTG--L 1200

Query: 520  TCKAFCKDGCRNGGACIAANV------------CACPQGFTGPSCETDIDECSDGFVQCD 567
             C+A   + CR+G AC AA+             C C  GF+GP C+T +  C      C 
Sbjct: 1201 RCEADINE-CRSG-ACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCES--QPCQ 1256

Query: 568  SRANCINLPG-----WYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNL 622
                C   PG      + C C   +         G  CE +         C     C   
Sbjct: 1257 HGGQCRPSPGPGGGLTFTCHCAQPFW--------GPRCERVAR-SCRELQCPVGVPCQQT 1307

Query: 623  DGGYDCRCPHGKN-------------------CTGDCIHDGKVKHNGQIWVLENDRCSVC 663
              G  C CP G +                       C+H G  +               C
Sbjct: 1308 PRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFR------C 1361

Query: 664  SCQNGFV-----------------MCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGE 706
            +C  G+                   C R  C  +    D  C  EC+   S  C    G+
Sbjct: 1362 ACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRG--DQRCDRECN---SPGCGWDGGD 1416

Query: 707  TLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQAD 763
               + GD W    +QC  LQ    CW L              + C P C +  C  D
Sbjct: 1417 CSLSVGDPW----RQCEALQ----CWRL-----------FNNSRCDPACSSPACLYD 1454



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 116/456 (25%), Positives = 162/456 (35%), Gaps = 108/456 (23%)

Query: 444 CAEGRHYCRENTMCVNTPG-SFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNT 502
           C +G   C     C   P     C+C  G++      C   D C +    C    +C ++
Sbjct: 43  CLDGSP-CANGGRCTQLPSREAACLCPPGWV---GERCQLEDPCHSGP--CAGRGVCQSS 96

Query: 503 V----GGHNCVCKPGYTGNGTTCKAFCKDG-CRNGGACIAAN----VCACPQGFTGPSCE 553
           V       +C C  G+ G   +    C    C +G  C        +C+CP G+ G SC 
Sbjct: 97  VVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCR 156

Query: 554 TDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPS----------------- 596
           +D+DEC  G   C     C+N PG + C+C  GY      +P+                 
Sbjct: 157 SDVDECRVG-EPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQS 215

Query: 597 --------------GESCE-DIDECGTGRHSCANDTICFNLDGGYDCRCP---HGKNCTG 638
                         G++CE ++D+C    H C N   C +    Y+C+CP    G+ CT 
Sbjct: 216 GDLTYDCACLPGFEGQNCEVNVDDC--PGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTE 273

Query: 639 D---CIHDGKVKHNGQIWVLENDRCSVCSCQNGFV--MCRRMVCDCENPTVDLFCCPECD 693
           D   C       HNG          S C C NG+    C + + DC   T   F    C 
Sbjct: 274 DVDECQLQPNACHNGGTCFNTLGGHS-CVCVNGWTGESCSQNIDDC--ATAVCFHGATCH 330

Query: 694 PRLSS-QCLHQNGET--LYNSGDTWVQN-CQQ--------------CRCLQG-------- 727
            R++S  C    G+T  L +  D  V N C +              C C  G        
Sbjct: 331 DRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQ 390

Query: 728 ---EVDCWPLPCPD----VECEFSILPE---NECCPRCVTD--PCQADTIRNDITKTCLD 775
              E      PC      V  + S L +       PRC TD   C +   RN    TCLD
Sbjct: 391 DVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQ--ATCLD 448

Query: 776 EMN------VVRFTGSSWIKHGTECTLCQCKNGHIC 805
            +       +  FTG+       EC    C NG +C
Sbjct: 449 RIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVC 484


>gi|24041035 notch 2 preproprotein [Homo sapiens]
          Length = 2471

 Score =  147 bits (370), Expect = 5e-35
 Identities = 167/605 (27%), Positives = 230/605 (38%), Gaps = 142/605 (23%)

Query: 288 IDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEG--- 344
           ID C N  C NG +  + +   N  CP +       G+ C E    C  Q      G   
Sbjct: 261 IDDCPNHRCQNGGVCVDGVNTYNCRCPPQWT-----GQFCTEDVDECLLQPNACQNGGTC 315

Query: 345 -ERNTVYSSSGVCVLY----ECKDQTMKLVESSGCPALDCPESHQITLSHSC-CKVCKGY 398
             RN  Y    VCV      +C +       +S  P   C +      S SC C   K  
Sbjct: 316 ANRNGGYGC--VCVNGWSGDDCSENIDDCAFASCTPGSTCIDR---VASFSCMCPEGKAG 370

Query: 399 DFCSERHNCMEN-----SICRN--LNDRAVCSCRDGFRALREDNAYC-EDIDECAEGR-H 449
             C     C+ N     ++C    LN + +C+C  G++      A C ED+DECA    +
Sbjct: 371 LLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKG-----ADCTEDVDECAMANSN 425

Query: 450 YCRENTMCVNTPGSFMCICKTGYIRIDDYSCT-EHDECITNQHNCDENALCFNTVGGHNC 508
            C     CVNT G+F C C  GY       C  + +EC ++   C  +A C + +GG  C
Sbjct: 426 PCEHAGKCVNTDGAFHCECLKGYA---GPRCEMDINECHSDP--CQNDATCLDKIGGFTC 480

Query: 509 VCKPGYTGNGTTCKAFCKD----GCRNGGACIAAN---VCACPQGFTGPSCETDIDECSD 561
           +C PG+   G  C+    +     C N G C+       C CP GFTGP C+ DID+CS 
Sbjct: 481 LCMPGF--KGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSS 538

Query: 562 GFVQCDSRANCINLPGWYHCECRDGYH--------DNGMFSP------------------ 595
               C + A CI+ P  Y C+C  G+         DN    P                  
Sbjct: 539 --TPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICN 596

Query: 596 ---SGESCED-IDECGTGRHSCANDTICFNLDGGYDCRC---PHGKNC--------TGDC 640
               G  C D IDEC +    C ND  C +L  GY C C     G NC        +  C
Sbjct: 597 PGYMGAICSDQIDECYSS--PCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPC 654

Query: 641 IH----DGKVKHN--------GQIWVLENDRCSVCSCQNGFVMCRRMV----CDCENPTV 684
           IH    DG  +++        GQ   ++ D C+   C+ G   C   V    C C     
Sbjct: 655 IHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKG-ATCINGVNGFRCICPEGPH 713

Query: 685 DLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDVECEFS 744
              C  + +  LS+ C+H N         T   +  +C C  G V         + CE  
Sbjct: 714 HPSCYSQVNECLSNPCIHGN--------CTGGLSGYKCLCDAGWV--------GINCE-- 755

Query: 745 ILPENECCPRCVTDPCQ----ADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCK 800
            + +NE    C+++PCQ     D + N    TC        F G +   +  EC    C 
Sbjct: 756 -VDKNE----CLSNPCQNGGTCDNLVNGYRCTCKK-----GFKGYNCQVNIDECASNPCL 805

Query: 801 NGHIC 805
           N   C
Sbjct: 806 NQGTC 810



 Score =  134 bits (338), Expect = 3e-31
 Identities = 154/618 (24%), Positives = 224/618 (36%), Gaps = 133/618 (21%)

Query: 271 ERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKEC 330
           E TC + G T +E + W D C +  C NG+  C T +     C     L    G+ C+  
Sbjct: 130 ECTCQV-GFTGKECQ-WTDACLSHPCANGS-TC-TTVANQFSC---KCLTGFTGQKCETD 182

Query: 331 KSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHS 390
            + C   G     G    +  S      Y+C  Q  +      C +L  P +    ++  
Sbjct: 183 VNECDIPGHCQHGGTCLNLPGS------YQC--QCPQGFTGQYCDSLYVPCAPSPCVNGG 234

Query: 391 CCKVCKGYDFCSERHNCM---ENSIC-RNLNDRAVCSCRDGFRALREDNAY--------- 437
            C+    + F     NC+   E S C RN++D     C++G   +   N Y         
Sbjct: 235 TCRQTGDFTF---ECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWT 291

Query: 438 ----CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEH-DECITNQHN 492
                ED+DEC    + C+    C N  G + C+C  G+   D   C+E+ D+C     +
Sbjct: 292 GQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDD---CSENIDDCAF--AS 346

Query: 493 CDENALCFNTVGGHNCVCKPGYTGNGTTCKAFC-KDGCRNGGAC-----IAANVCACPQG 546
           C   + C + V   +C+C  G  G        C  + C  G  C         +C CPQG
Sbjct: 347 CTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQG 406

Query: 547 FTGPSCETDIDECS-DGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE-DID 604
           + G  C  D+DEC+      C+    C+N  G +HCEC  GY        +G  CE DI+
Sbjct: 407 YKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGY--------AGPRCEMDIN 458

Query: 605 ECGTGRHSCANDTICFNLDGGYDCRCP---HGKNC--------TGDCIHDG----KVKH- 648
           EC +    C ND  C +  GG+ C C     G +C        +  C+++G    KV   
Sbjct: 459 ECHS--DPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRF 516

Query: 649 --------NGQIWVLENDRCSVCSCQNGFVMC----RRMVCDCENPTVDLFC---CPECD 693
                    G +  ++ D CS   C NG   C        C C      + C      CD
Sbjct: 517 QCLCPPGFTGPVCQIDIDDCSSTPCLNG-AKCIDHPNGYECQCATGFTGVLCEENIDNCD 575

Query: 694 PRLSSQCLHQNGETLY----NSG------DTWVQNCQQCRCLQG----------EVDCWP 733
           P        Q+G   Y    N G         +  C    CL            + +C P
Sbjct: 576 PDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQP 635

Query: 734 LPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVR------FTGSSW 787
                V CE +          C ++PC        I   C+D +N         FTG   
Sbjct: 636 -GTSGVNCEINF-------DDCASNPC--------IHGICMDGINRYSCVCSPGFTGQRC 679

Query: 788 IKHGTECTLCQCKNGHIC 805
                EC    C+ G  C
Sbjct: 680 NIDIDECASNPCRKGATC 697



 Score =  116 bits (290), Expect = 1e-25
 Identities = 137/540 (25%), Positives = 187/540 (34%), Gaps = 116/540 (21%)

Query: 288  IDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERN 347
            I+ C +  CLN     + L      CPL        GK C+   ++C             
Sbjct: 1026 INECSSHPCLNEGTCVDGLGTYRCSCPLGYT-----GKNCQTLVNLCS-----------R 1069

Query: 348  TVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNC 407
            +   + G CV  + + Q +     SG     C       + +  C +          H C
Sbjct: 1070 SPCKNKGTCVQKKAESQCLC---PSGWAGAYCD------VPNVSCDIAASRRGVLVEHLC 1120

Query: 408  MENSICRNLNDRAVCSCRDGFRALREDNAYCED-IDECAEGRHYCRENTMCVNTPGSFMC 466
              + +C N  +   C C  G+       +YCE+ +DECA     C+    C +  G + C
Sbjct: 1121 QHSGVCINAGNTHYCQCPLGYTG-----SYCEEQLDECASNP--CQHGATCSDFIGGYRC 1173

Query: 467  ICKTGYIRID-DYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFC 525
             C  GY  ++ +Y   E DEC      C     C + V    C C PG    G  C+   
Sbjct: 1174 ECVPGYQGVNCEY---EVDEC--QNQPCQNGGTCIDLVNHFKCSCPPGT--RGLLCEENI 1226

Query: 526  KD-----GCRNGGAC---IAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPG 577
             D      C NGG C   I    C C  GF G  CE DI+EC       +   +CI L  
Sbjct: 1227 DDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTN 1286

Query: 578  WYHCECRDGYHDNGMFSPSGESCED-IDECGTGRHSCANDTIC---FNLDGGYDCRCP-- 631
             Y C CR  +        +G  CE  +D C   +  C N   C    N+  G+ CRCP  
Sbjct: 1287 DYLCVCRSAF--------TGRHCETFVDVC--PQMPCLNGGTCAVASNMPDGFICRCPPG 1336

Query: 632  -HGKNCTGDCIHDGKVK-HNGQ--IWVLENDRC---SVCSCQNGFVM--CRR-------- 674
              G  C   C   G+VK   G+  +      RC   S   C++G     C+         
Sbjct: 1337 FSGARCQSSC---GQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQR 1393

Query: 675  ----MVCDCENP----TVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQ 726
                  C C  P      +L+  P   P   + CL Q        G    + C    C  
Sbjct: 1394 QPPYYSCQCAPPFSGSRCELYTAPPSTP--PATCLSQYCADKARDG-VCDEACNSHACQW 1450

Query: 727  GEVDC-------W-----PLPCPDVECEFSILPENECCPRCVTDPCQADTIR-NDITKTC 773
               DC       W     PLPC D          N+C   C T  C  D       +KTC
Sbjct: 1451 DGGDCSLTMENPWANCSSPLPCWD-------YINNQCDELCNTVECLFDNFECQGNSKTC 1503



 Score =  112 bits (280), Expect = 1e-24
 Identities = 131/498 (26%), Positives = 181/498 (36%), Gaps = 122/498 (24%)

Query: 407 CMENSICRNL-NDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTP--GS 463
           C+   +C    N    C C +GF        YC+  D C + R  C+    CV     G 
Sbjct: 35  CVNEGMCVTYHNGTGYCKCPEGFLG-----EYCQHRDPCEKNR--CQNGGTCVAQAMLGK 87

Query: 464 FMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKA 523
             C C +G+   D    T H  C  ++   +       +   + C C+ G+TG       
Sbjct: 88  ATCRCASGFTGEDCQYSTSHP-CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTD 146

Query: 524 FC-KDGCRNGGACIA-ANV--CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWY 579
            C    C NG  C   AN   C C  GFTG  CETD++EC D    C     C+NLPG Y
Sbjct: 147 ACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNEC-DIPGHCQHGGTCLNLPGSY 205

Query: 580 HCECRDGY---HDNGMFSP----------------------------SGESCE-DIDECG 607
            C+C  G+   + + ++ P                             G +CE +ID+C 
Sbjct: 206 QCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDC- 264

Query: 608 TGRHSCANDTICFNLDGGYDCRCP---HGKNCTGD---CIHDGKVKHNGQIWVLENDRCS 661
              H C N  +C +    Y+CRCP    G+ CT D   C+       NG      N    
Sbjct: 265 -PNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYG 323

Query: 662 VCSCQNGFV--MCRRMVCDCENPTVDLFCCP--ECDPRLSS-QCLHQNGET--LYNSGDT 714
            C C NG+    C   + DC   +    C P   C  R++S  C+   G+   L +  D 
Sbjct: 324 -CVCVNGWSGDDCSENIDDCAFAS----CTPGSTCIDRVASFSCMCPEGKAGLLCHLDDA 378

Query: 715 WVQN-CQQ--------------CRCLQG--EVDCWPLPCPDVECEFSILPENEC-----C 752
            + N C +              C C QG    DC      DV+ E ++   N C     C
Sbjct: 379 CISNPCHKGALCDTNPLNGQYICTCPQGYKGADC----TEDVD-ECAMANSNPCEHAGKC 433

Query: 753 -----------------PRCVTD--PCQADTIRNDITKTCLDEMN------VVRFTGSSW 787
                            PRC  D   C +D  +ND   TCLD++       +  F G   
Sbjct: 434 VNTDGAFHCECLKGYAGPRCEMDINECHSDPCQND--ATCLDKIGGFTCLCMPGFKGVHC 491

Query: 788 IKHGTECTLCQCKNGHIC 805
                EC    C N   C
Sbjct: 492 ELEINECQSNPCVNNGQC 509



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 106/441 (24%), Positives = 161/441 (36%), Gaps = 84/441 (19%)

Query: 407  CMENSICRNLNDRAVCSCRDGFRALREDNAYCE-DIDECAEGRHYCRENTMCVNTPGSFM 465
            C     C NL +   C+C+ GF+        C+ +IDECA     C     C +    + 
Sbjct: 766  CQNGGTCDNLVNGYRCTCKKGFKGYN-----CQVNIDECASNP--CLNQGTCFDDISGYT 818

Query: 466  CICKTGYIRIDDYSC-TEHDECITNQHNCDENALCFNTVG--GHNCVCKPGYTGNGTTCK 522
            C C   Y      +C T    C  N   C+  A+C  +     + C+C PG+ G   T  
Sbjct: 819  CHCVLPYT---GKNCQTVLAPCSPNP--CENAAVCKESPNFESYTCLCAPGWQGQRCTID 873

Query: 523  A--FCKDGCRNGGACI---AANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPG 577
                    C N G C     + +C CP GF+G  CE DID+C      C +  +C++   
Sbjct: 874  IDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLAN--PCQNGGSCMDGVN 931

Query: 578  WYHCECRDGYHDNGMFSPSGESCE-DIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNC 636
             + C C  G+        +G+ C+ D++EC +    C N   C +    Y C+C  G   
Sbjct: 932  TFSCLCLPGF--------TGDKCQTDMNECLS--EPCKNGGTCSDYVNSYTCKCQAG--- 978

Query: 637  TGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVM---CRRMVCDCENPTVDLFCCPECD 693
                  DG    N        + C+  SC NG           C C       FC  E +
Sbjct: 979  -----FDGVHCEN------NINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEIN 1027

Query: 694  PRLSSQCLHQNGETLYNSGDTWVQNC------QQCRCLQGEVDCWPLPCPDVECEFSILP 747
               S  CL++   T  +   T+  +C      + C+ L     C   PC +         
Sbjct: 1028 ECSSHPCLNEG--TCVDGLGTYRCSCPLGYTGKNCQTLVNL--CSRSPCKNKGTCVQKKA 1083

Query: 748  ENEC-CPRCVTDP-CQADTIRNDITKT---------------CLDEMNV------VRFTG 784
            E++C CP       C    +  DI  +               C++  N       + +TG
Sbjct: 1084 ESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTG 1143

Query: 785  SSWIKHGTECTLCQCKNGHIC 805
            S   +   EC    C++G  C
Sbjct: 1144 SYCEEQLDECASNPCQHGATC 1164


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  147 bits (370), Expect = 5e-35
 Identities = 99/287 (34%), Positives = 124/287 (43%), Gaps = 38/287 (13%)

Query: 371  SSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRA 430
            S G  +  CP    +    S    C   D C+  + C  +  C N      CSC  G   
Sbjct: 5084 SKGDRSNQCPSGFTLD---SVGPFCADEDECAAGNPCSHS--CHNAMGTYYCSCPKGL-T 5137

Query: 431  LREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCI--CKTGYIRIDD-YSCTEHDECI 487
            +  D   C+DIDECA GRH C     C NT GS+ C+  C +G+ R  D  SC + +EC 
Sbjct: 5138 IAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINEC- 5196

Query: 488  TNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCK-------------AFCKDGCRNGGA 534
              Q +   +  CFN +G  +C C+PGY   G  C                CK+  R G  
Sbjct: 5197 --QESSPCHQRCFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKN-TRGGYK 5253

Query: 535  CIAANVCACPQGFTGPSCET--DIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGM 592
            CI      CP G T     T  DIDEC DG  QC     C N  G Y C C  GY   G+
Sbjct: 5254 CIDL----CPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGV 5309

Query: 593  FSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGD 639
                G  C DI+EC      CA+   C N  G + C CP G++  GD
Sbjct: 5310 ----GRPCMDINECEQVPKPCAHQ--CSNTPGSFKCICPPGQHLLGD 5350



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 110/436 (25%), Positives = 163/436 (37%), Gaps = 67/436 (15%)

Query: 293  NCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSS 352
            +C    GT  C         CP    +A  DG+ C++    C     T   G+       
Sbjct: 5120 SCHNAMGTYYCS--------CPKGLTIA-ADGRTCQDIDE-CALGRHTCHAGQDCDNTIG 5169

Query: 353  SGVCVLYECKDQTMKLVESSGCPAL-DCPES---HQ-----ITLSHSCCKVCKGYDF--- 400
            S  CV+  C     +  +   C  + +C ES   HQ     I   H  C+   GY     
Sbjct: 5170 SYRCVV-RCGSGFRRTSDGLSCQDINECQESSPCHQRCFNAIGSFHCGCE--PGYQLKGR 5226

Query: 401  -CSERHNCMENSICRNLNDRAVCSCRDGFRAL--------REDNAYCEDIDECAEGRHYC 451
             C + + C +N +CR   D+   + R G++ +        + +N  C DIDEC +G H C
Sbjct: 5227 KCMDVNECRQN-VCRP--DQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDECKDGTHQC 5283

Query: 452  RENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVC 510
            R N +C NT GS+ C+C  GY  +     C + +EC      C     C NT G   C+C
Sbjct: 5284 RYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQ--CSNTPGSFKCIC 5341

Query: 511  KPG--YTGNGTTCKAFCKDGCRNGGACIA----ANVCACPQGFTGPSCETDIDECSDGFV 564
             PG    G+G +C     +   N G   +    A        +               + 
Sbjct: 5342 PPGQHLLGDGKSCAGL--ERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYS 5399

Query: 565  QC-DSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLD 623
            +  +SR +           C +G         S ++C DIDEC     +C ++  C N  
Sbjct: 5400 EYRNSRTSLSRTRRTIRKTCPEG------SEASHDTCVDIDEC-ENTDACQHE--CKNTF 5450

Query: 624  GGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS---VCSCQNGFVMCRRMVC--D 678
            G Y C CP G   T    H+GK   +    + +N  C    +C    G   C    C  +
Sbjct: 5451 GSYQCICPPGYQLT----HNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPN 5506

Query: 679  CENPTVDLFCCPECDP 694
             +   V  FC   C P
Sbjct: 5507 YQRDPVSGFCLKNCPP 5522


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score =  146 bits (368), Expect = 9e-35
 Identities = 152/595 (25%), Positives = 224/595 (37%), Gaps = 124/595 (20%)

Query: 267 QCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKC 326
           +C C     + G T +  E  ID C    C NG    + +   N  CP +       G+ 
Sbjct: 242 ECAC-----LPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWT-----GQY 291

Query: 327 CKECKSICQFQGRTYFEGE--RNTVYSSSGVCVL-YECKDQTMKLVESSGCPALDCPESH 383
           C E    CQ        G    NT    + VCV  +  +D +  + + +          H
Sbjct: 292 CTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCH 351

Query: 384 QITLSHSC-CK------VCKGYDFCSERHNCMENSIC--RNLNDRAVCSCRDGFRALRED 434
               S  C C       +C   D C   + C E S C    +N +A+C+C  G+      
Sbjct: 352 DRVASFYCECPHGRTGLLCHLNDACIS-NPCNEGSNCDTNPVNGKAICTCPSGYTG---- 406

Query: 435 NAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCD 494
            A  +D+DEC+ G + C     C+NT GSF C C  GY         + +EC++N   C 
Sbjct: 407 PACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGY--TGPRCEIDVNECVSNP--CQ 462

Query: 495 ENALCFNTVGGHNCVCKPGYTG-----NGTTCKAFCKDGCRNGGAC---IAANVCACPQG 546
            +A C + +G   C+C PGY G     N   C       C + G C   I    C CP G
Sbjct: 463 NDATCLDQIGEFQCICMPGYEGVHCEVNTDEC---ASSPCLHNGRCLDKINEFQCECPTG 519

Query: 547 FTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE-DIDE 605
           FTG  C+ D+DEC+     C + A C++ P  Y C C +GY        +G  CE DIDE
Sbjct: 520 FTGHLCQYDVDECAS--TPCKNGAKCLDGPNTYTCVCTEGY--------TGTHCEVDIDE 569

Query: 606 C-------GTGRHSCANDT-ICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLEN 657
           C       G+ +   A  T +C     G+ C     +  +  C H G  +        + 
Sbjct: 570 CDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQ--------DR 621

Query: 658 DRCSVCSCQNGFV--MCRRMVCDCENPTVDLFCCPE--------CDPRLSSQCLHQN--- 704
           D   +C C  G     C   + DC +   D   C +        C+P  +    + N   
Sbjct: 622 DNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDE 681

Query: 705 --GETLYNSGDTWVQNCQQ------CRCLQGEVDCWPLPCPDVECEFSILPENECCPRCV 756
             G   +N G      C+       CRC +G  D  P    +V               C 
Sbjct: 682 CAGNPCHNGG-----TCEDGINGFTCRCPEGYHD--PTCLSEVN-------------ECN 721

Query: 757 TDPCQADTIRNDITKTCLDEMNVVR------FTGSSWIKHGTECTLCQCKNGHIC 805
           ++PC        +   C D +N  +      ++G++   +  EC    C NG  C
Sbjct: 722 SNPC--------VHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTC 768



 Score =  126 bits (317), Expect = 7e-29
 Identities = 114/436 (26%), Positives = 167/436 (38%), Gaps = 87/436 (19%)

Query: 407 CMENSICRNLNDRAVCSCRDGFRALREDNAYCE-DIDECAEGRHYCRENTMCVNTPGSFM 465
           C+ N  C +  +   C C  GF         C+ D+DECA     C+    C++ P ++ 
Sbjct: 499 CLHNGRCLDKINEFQCECPTGFTG-----HLCQYDVDECASTP--CKNGAKCLDGPNTYT 551

Query: 466 CICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNG--TTCKA 523
           C+C  GY     +   + DEC  +   C   + C + V    C+C+PGYTG+   T    
Sbjct: 552 CVCTEGYT--GTHCEVDIDEC--DPDPCHYGS-CKDGVATFTCLCRPGYTGHHCETNINE 606

Query: 524 FCKDGCRNGGACIA---ANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYH 580
                CR+GG C     A +C C +G TGP+CE ++D+C+     CDS   C++    Y 
Sbjct: 607 CSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASS--PCDS-GTCLDKIDGYE 663

Query: 581 CECRDGYHDNGMFSPSGESCE-DIDECGTGRHSCANDTICFNLDGGYDCRCP---HGKNC 636
           C C  GY        +G  C  +IDEC    + C N   C +   G+ CRCP   H   C
Sbjct: 664 CACEPGY--------TGSMCNINIDEC--AGNPCHNGGTCEDGINGFTCRCPEGYHDPTC 713

Query: 637 TGD--------CIH------------DGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRM- 675
             +        C+H            D     +G    + N+ C    C NG   C+ M 
Sbjct: 714 LSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGT-CKDMT 772

Query: 676 ---VCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNC--QQCRCLQGEVD 730
              VC C        C    +   S+ CL+Q          T + +    +C CL     
Sbjct: 773 SGYVCTCREGFSGPNCQTNINECASNPCLNQG---------TCIDDVAGYKCNCL----- 818

Query: 731 CWPLPCPDVECEFSILPENECCPRCVTDPCQ-ADTIRNDITKTCLDEMNVVRFTGSSWIK 789
              LP     CE  + P       C   PC+     R          +    + G +   
Sbjct: 819 ---LPYTGATCEVVLAP-------CAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEV 868

Query: 790 HGTECTLCQCKNGHIC 805
              EC L  C++G  C
Sbjct: 869 DINECVLSPCRHGASC 884



 Score =  120 bits (300), Expect = 7e-27
 Identities = 127/498 (25%), Positives = 179/498 (35%), Gaps = 131/498 (26%)

Query: 407  CMENSICRNLNDRAVCSCRDGFRALREDNAYCE-DIDECAEGRHYCRENTMCVNTPGSFM 465
            C     C +  + A C C  GFR       +CE DI+ECA     CR    C +   S+ 
Sbjct: 916  CHNGGSCTDGINTAFCDCLPGFRG-----TFCEEDINECASDP--CRNGANCTDCVDSYT 968

Query: 466  CICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFC 525
            C C  G+  I      E++     + +C     C + +    C+C PG+TG+      +C
Sbjct: 969  CTCPAGFSGIH----CENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGS------YC 1018

Query: 526  KDG--------CRNGGAC---IAANVCACPQGFTGPSCETDID----------------- 557
            +          C +GG C     +  C CPQG+TGP+C+  +                  
Sbjct: 1019 QHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTH 1078

Query: 558  -----ECSDGF---------VQCDSRAN---------------CINLPGWYHCECRDGYH 588
                 EC  G+         V C+  A                C++    +HC C+ GY 
Sbjct: 1079 TQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGY- 1137

Query: 589  DNGMFSPSGESCED-IDECGTGRHSCANDTICFNLDGGYDCRCP---HGKNCTGDCIHDG 644
                   +G  CED +DEC      C N   C +  GGY C+C    HG NC+ +   D 
Sbjct: 1138 -------TGSYCEDLVDECSPS--PCQNGATCTDYLGGYSCKCVAGYHGVNCSEEI--DE 1186

Query: 645  KVKH---NGQIWVLENDRCSVCSCQNGF--VMCRRMVCDCENPTVDLFCCPECDPRLSSQ 699
             + H   NG    L+      CSC  G   V C   V DC  P   +   P+C    +  
Sbjct: 1187 CLSHPCQNGGT-CLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFN--NGT 1243

Query: 700  CLHQNGETLYNSGDTWVQNCQQCRCLQGEV-DCWPLPCP------------DVECEFSIL 746
            C+ Q G         +V      RC +G+V +C   PC             D  CE    
Sbjct: 1244 CVDQVGGYSCTCPPGFVGE----RC-EGDVNECLSNPCDARGTQNCVQRVNDFHCECRAG 1298

Query: 747  PENECCPRCVTDPCQADTIRNDITKTCLDEMNVVR---------FTGSSWIKHGTECTLC 797
                 C   V + C+    +N    TC    N  R         F G++       C   
Sbjct: 1299 HTGRRC-ESVINGCKGKPCKNG--GTCAVASNTARGFICKCPAGFEGATCENDARTCGSL 1355

Query: 798  QCKNGHICCS--VDPQCL 813
            +C NG  C S    P CL
Sbjct: 1356 RCLNGGTCISGPRSPTCL 1373



 Score =  119 bits (298), Expect = 1e-26
 Identities = 94/331 (28%), Positives = 127/331 (38%), Gaps = 70/331 (21%)

Query: 407  CMENSICRNLNDRAVCSCRDGFRALREDNAYCED-IDECAEGRHYCRENTMCVNTPGSFM 465
            C    +C +  +   C C+ G+       +YCED +DEC+     C+    C +  G + 
Sbjct: 1116 CQHGGLCVDAGNTHHCRCQAGYTG-----SYCEDLVDECSPSP--CQNGATCTDYLGGYS 1168

Query: 466  CICKTGYIRIDDYSCTEH-DECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAF 524
            C C  GY  ++   C+E  DEC++  H C     C +    + C C  G    G  C+  
Sbjct: 1169 CKCVAGYHGVN---CSEEIDECLS--HPCQNGGTCLDLPNTYKCSCPRGT--QGVHCEIN 1221

Query: 525  CKD------------GCRNGGACI---AANVCACPQGFTGPSCETDIDECSDGFVQCDSR 569
              D             C N G C+       C CP GF G  CE D++EC      CD+R
Sbjct: 1222 VDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNECLSN--PCDAR 1279

Query: 570  A--NCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTIC---FNLDG 624
               NC+     +HCECR G+        +G  CE +     G+  C N   C    N   
Sbjct: 1280 GTQNCVQRVNDFHCECRAGH--------TGRRCESVINGCKGK-PCKNGGTCAVASNTAR 1330

Query: 625  GYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMC---RRMVCDCEN 681
            G+ C+CP G      C +D +              C    C NG       R   C C  
Sbjct: 1331 GFICKCPAGFE-GATCENDART-------------CGSLRCLNGGTCISGPRSPTCLCLG 1376

Query: 682  PTVDLFCCPECDPRLSSQCLHQNGETLYNSG 712
            P    F  PEC    SS CL   G   YN G
Sbjct: 1377 P----FTGPECQFPASSPCL--GGNPCYNQG 1401



 Score =  115 bits (289), Expect = 1e-25
 Identities = 123/451 (27%), Positives = 172/451 (38%), Gaps = 119/451 (26%)

Query: 409  ENSICRNLNDRAVCSCRDGFRALREDNAYCE-DIDECAEGRHYCRENTMCVNTPGSFMCI 467
            ++  C +  D   C+C  G+       + C  +IDECA     C     C +    F C 
Sbjct: 651  DSGTCLDKIDGYECACEPGYTG-----SMCNINIDECAGNP--CHNGGTCEDGINGFTCR 703

Query: 468  CKTGYIRIDDYSC-TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTG-----NGTTC 521
            C  GY    D +C +E +EC  N + C   A C +++ G+ C C PG++G     N   C
Sbjct: 704  CPEGY---HDPTCLSEVNEC--NSNPCVHGA-CRDSLNGYKCDCDPGWSGTNCDINNNEC 757

Query: 522  KAFCKDGCRNGGAC---IAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGW 578
            ++   + C NGG C    +  VC C +GF+GP+C+T+I+EC+     C ++  CI+    
Sbjct: 758  ES---NPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASN--PCLNQGTCIDDVAG 812

Query: 579  YHCE---------------------CRDG--------YHDNGMFSPS---GESCE-DIDE 605
            Y C                      CR+G        Y       P+   G++CE DI+E
Sbjct: 813  YKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINE 872

Query: 606  CGTGRHSCANDTICFNLDGGYDCRCP---HGKNCTGDCIHDGKVK--HNGQIWVLENDRC 660
            C      C +   C N  GGY C C     G+NC  D I D +    HNG          
Sbjct: 873  CVLS--PCRHGASCQNTHGGYRCHCQAGYSGRNCETD-IDDCRPNPCHNGG--------- 920

Query: 661  SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ 720
               SC +G        CDC       FC  + +   S  C  +NG            NC 
Sbjct: 921  ---SCTDGI---NTAFCDCLPGFRGTFCEEDINECASDPC--RNG-----------ANCT 961

Query: 721  QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV 780
             C      VD +   CP     FS +      P C    C           TC+D +N  
Sbjct: 962  DC------VDSYTCTCP---AGFSGIHCENNTPDCTESSCFNG-------GTCVDGINSF 1005

Query: 781  R------FTGSSWIKHGTECTLCQCKNGHIC 805
                   FTGS       EC    C +G  C
Sbjct: 1006 TCLCPPGFTGSYCQHDVNECDSQPCLHGGTC 1036



 Score =  111 bits (277), Expect = 3e-24
 Identities = 125/492 (25%), Positives = 177/492 (35%), Gaps = 140/492 (28%)

Query: 403  ERHNCMENSICRNLNDRAVCSCRDGFRA-------------------------------- 430
            E + C+    C+++    VC+CR+GF                                  
Sbjct: 758  ESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNC 817

Query: 431  -LREDNAYCEDI-DECAEGRHYCRENTMCVNTPG--SFMCICKTGYIRIDDYSC-TEHDE 485
             L    A CE +   CA     CR    C  +    SF C+C TG+      +C  + +E
Sbjct: 818  LLPYTGATCEVVLAPCAPSP--CRNGGECRQSEDYESFSCVCPTGW---QGQTCEVDINE 872

Query: 486  CITNQHNCDENALCFNTVGGHNCVCKPGYTG-NGTTCKAFCK-DGCRNGGAC---IAANV 540
            C+ +   C   A C NT GG+ C C+ GY+G N  T    C+ + C NGG+C   I    
Sbjct: 873  CVLSP--CRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAF 930

Query: 541  CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
            C C  GF G  CE DI+EC+     C + ANC +    Y C C  G+        SG  C
Sbjct: 931  CDCLPGFRGTFCEEDINECASD--PCRNGANCTDCVDSYTCTCPAGF--------SGIHC 980

Query: 601  E-DIDECGTGRHSCANDTICFNLDGGYDCRCP---HGKNCTGD--------CIHDGKVKH 648
            E +  +C     SC N   C +    + C CP    G  C  D        C+H G  + 
Sbjct: 981  ENNTPDC--TESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQ- 1037

Query: 649  NGQIWVLENDRCSV--CSCQNGFV--MCRRMV----------------------CDCENP 682
                     D C    C+C  G+    C+ +V                      C+C + 
Sbjct: 1038 ---------DGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSG 1088

Query: 683  TVDLFC-CPECDPRLSSQCLHQNGETLYNSGDTWVQ--NCQQCRCLQGEVDCWPLPCPDV 739
               L+C  P     +++Q    +   L   G   V   N   CRC  G    +   C D+
Sbjct: 1089 WTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSY---CEDL 1145

Query: 740  ECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMN------VVRFTGSSWIKHGTE 793
                     +EC P     PCQ          TC D +       V  + G +  +   E
Sbjct: 1146 --------VDECSP----SPCQNGA-------TCTDYLGGYSCKCVAGYHGVNCSEEIDE 1186

Query: 794  CTLCQCKNGHIC 805
            C    C+NG  C
Sbjct: 1187 CLSHPCQNGGTC 1198



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 119/469 (25%), Positives = 166/469 (35%), Gaps = 113/469 (24%)

Query: 401 CSER-HNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMC-- 457
           CS+    C+    C   N    C C   F   R     C+D + C      C+    C  
Sbjct: 24  CSQPGETCLNGGKCEAANGTEACVCGGAFVGPR-----CQDPNPCLSTP--CKNAGTCHV 76

Query: 458 VNTPG--SFMCICKTGYIRIDDYSCTEHDE-CITNQHNCDENALC-FNTVGGHNCVCKPG 513
           V+  G   + C C  G+        T  D  C+TN   C     C   T+  + C C PG
Sbjct: 77  VDRRGVADYACSCALGFS--GPLCLTPLDNACLTNP--CRNGGTCDLLTLTEYKCRCPPG 132

Query: 514 YTGNGTTCKAFCKDG-CRNGGACI---AANVCACPQGFTGPSCETDIDECSDGFVQCDSR 569
           ++G        C    C NGG C+   A+ +C CP  F GP+C  D++EC      C   
Sbjct: 133 WSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHG 192

Query: 570 ANCINLPGWYHCECRDGY-----------------HDNGMFSP--------------SGE 598
             C N  G Y C CR  +                  + G   P              +G+
Sbjct: 193 GTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQ 252

Query: 599 SCED-IDECGTGRHSCANDTICFNLDGGYDCRCP---HGKNCTGD----------CIHDG 644
           +CE+ ID+C    ++C N   C +    Y+CRCP    G+ CT D          C + G
Sbjct: 253 NCEENIDDC--PGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGG 310

Query: 645 KV--KHNGQIWVLEN-----------DRCSVCSCQNGFVMCRRMV---CDCENPTVDLFC 688
                H G   V  N           D C+  +C +G     R+    C+C +    L C
Sbjct: 311 TCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLC 370

Query: 689 CPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQG--------EVDCWPL---PCP 737
                  L+  C+        N     V     C C  G        +VD   L   PC 
Sbjct: 371 ------HLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCE 424

Query: 738 DVECEFSILPENEC-C------PRCVTD--PCQADTIRNDITKTCLDEM 777
                 + L   EC C      PRC  D   C ++  +ND   TCLD++
Sbjct: 425 HAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQND--ATCLDQI 471



 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 124/524 (23%), Positives = 182/524 (34%), Gaps = 126/524 (24%)

Query: 266  DQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVD-- 323
            D C   R    +G T    ++ +  C +  C NG    +T      +CP      Y D  
Sbjct: 1038 DGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVP 1097

Query: 324  GKCCK--------ECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCP 375
               C+        +   +CQ  G     G  +     +G    Y C+D    LV+   C 
Sbjct: 1098 SVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSY-CED----LVDE--CS 1150

Query: 376  ALDCPESHQIT--LSHSCCKVCKGYDF--CSER------HNCMENSICRNLNDRAVCSCR 425
               C      T  L    CK   GY    CSE       H C     C +L +   CSC 
Sbjct: 1151 PSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCP 1210

Query: 426  DGFRALREDNAYCE-DIDEC------AEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDY 478
             G + +     +CE ++D+C            C  N  CV+  G + C C  G++   + 
Sbjct: 1211 RGTQGV-----HCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFV--GER 1263

Query: 479  SCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTG----------------NGTTCK 522
               + +EC++N  +      C   V   +C C+ G+TG                NG TC 
Sbjct: 1264 CEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCA 1323

Query: 523  -------------------AFCKDG--------CRNGGACIA---ANVCACPQGFTGPSC 552
                               A C++         C NGG CI+   +  C C   FTGP C
Sbjct: 1324 VASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPEC 1383

Query: 553  ETDIDECSDGFVQCDSRANC--INLPGWYHCECRDGYHDNGM------FSPSG------- 597
            +        G   C ++  C   +   +Y C C   +  NG+      +S  G       
Sbjct: 1384 QFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKF--NGLLCHILDYSFGGGAGRDIP 1441

Query: 598  -----ESCEDIDEC--GTGRHSCA---NDTICFNLDGGYDCRCPHG---KNCTGDCIHDG 644
                 E+CE + EC    G   C+   N+  C   DGG DC        KNCT   +   
Sbjct: 1442 PPLIEEACE-LPECQEDAGNKVCSLQCNNHAC-GWDGG-DCSLNFNDPWKNCT-QSLQCW 1497

Query: 645  KVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLFC 688
            K   +G      + +C+   C      C+R    C NP  D +C
Sbjct: 1498 KYFSDGHC----DSQCNSAGCLFDGFDCQRAEGQC-NPLYDQYC 1536


>gi|40807489 egf-like module containing, mucin-like, hormone
           receptor-like sequence 1 [Homo sapiens]
          Length = 886

 Score =  142 bits (359), Expect = 1e-33
 Identities = 89/251 (35%), Positives = 118/251 (47%), Gaps = 41/251 (16%)

Query: 395 CKGYDFCSERHN-CMENSICRNLNDRAVCSCRDGFRAL--------REDNAYCEDIDECA 445
           CK  D CS+    C  NS C+NL+ R  CSC DGF +         +  N  C DI+EC 
Sbjct: 78  CKDIDECSQSPQPCGPNSSCKNLSGRYKCSCLDGFSSPTGNDWVPGKPGNFSCTDINECL 137

Query: 446 EGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGG 505
                C E++ CVN+ GS+ C C+ G+I  +  +C + DEC  +   C E+A C NTVG 
Sbjct: 138 TSS-VCPEHSDCVNSMGSYSCSCQVGFISRNS-TCEDVDEC-ADPRACPEHATCNNTVGN 194

Query: 506 HNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQ 565
           ++C C PG+  +                           QG    SCE DIDEC++    
Sbjct: 195 YSCFCNPGFESSSGHLSF---------------------QGLKA-SCE-DIDECTE---M 228

Query: 566 CDSRANCINLPGWYHCECRDGYH-DNGM--FSPSGESCEDIDECGTGRHSCANDTICFNL 622
           C   + C N PG Y C C  G+   NG   F+  G  C DIDEC     +C  ++IC N 
Sbjct: 229 CPINSTCTNTPGSYFCTCHPGFAPSNGQLNFTDQGVECRDIDECRQDPSTCGPNSICTNA 288

Query: 623 DGGYDCRCPHG 633
            G Y C C  G
Sbjct: 289 LGSYSCGCIAG 299



 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 59/183 (32%), Positives = 83/183 (45%), Gaps = 31/183 (16%)

Query: 359 YECKDQTMKLVESSGCPA-LDCPESHQITLSHSC-CKV--------CKGYDFCSERHNCM 408
           + C D   + + SS CP   DC  S     S+SC C+V        C+  D C++   C 
Sbjct: 128 FSCTDIN-ECLTSSVCPEHSDCVNSMG---SYSCSCQVGFISRNSTCEDVDECADPRACP 183

Query: 409 ENSICRNLNDRAVCSCRDGFRA------LREDNAYCEDIDECAEGRHYCRENTMCVNTPG 462
           E++ C N      C C  GF +       +   A CEDIDEC E    C  N+ C NTPG
Sbjct: 184 EHATCNNTVGNYSCFCNPGFESSSGHLSFQGLKASCEDIDECTE---MCPINSTCTNTPG 240

Query: 463 SFMCICKTGY------IRIDDYS--CTEHDECITNQHNCDENALCFNTVGGHNCVCKPGY 514
           S+ C C  G+      +   D    C + DEC  +   C  N++C N +G ++C C  G+
Sbjct: 241 SYFCTCHPGFAPSNGQLNFTDQGVECRDIDECRQDPSTCGPNSICTNALGSYSCGCIAGF 300

Query: 515 TGN 517
             N
Sbjct: 301 HPN 303



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 48/154 (31%), Positives = 64/154 (41%), Gaps = 21/154 (13%)

Query: 557 DECSDGFVQCDSRANCINLPGWYHCECRDGY-HDNGM--FSPSGESCEDIDECGTGRHSC 613
           + C D  + C + A C N    Y+C C+ G+   NG   F   G  C+DIDEC      C
Sbjct: 33  NNCRDSTL-CPAYATCTNTVDSYYCACKQGFLSSNGQNHFKDPGVRCKDIDECSQSPQPC 91

Query: 614 ANDTICFNLDGGYDCRCPHG-KNCTGDCIHDGKVKHNGQIWVLENDRCSV---------- 662
             ++ C NL G Y C C  G  + TG+    GK  +     + E    SV          
Sbjct: 92  GPNSSCKNLSGRYKCSCLDGFSSPTGNDWVPGKPGNFSCTDINECLTSSVCPEHSDCVNS 151

Query: 663 -----CSCQNGFVMCRRMVCDCENPTVDLFCCPE 691
                CSCQ GF+  R   C+  +   D   CPE
Sbjct: 152 MGSYSCSCQVGFI-SRNSTCEDVDECADPRACPE 184


>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
          Length = 1184

 Score =  139 bits (349), Expect = 1e-32
 Identities = 115/400 (28%), Positives = 150/400 (37%), Gaps = 67/400 (16%)

Query: 401  CSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNT 460
            C +   C +  +C  +   A+CSC  G+ A+  D   CEDI+EC    H C     CVNT
Sbjct: 683  CKDNGPCKQ--VCSTVGGSAICSCFPGY-AIMADGVSCEDINECVTDLHTCSRGEHCVNT 739

Query: 461  PGSFMC----ICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTG 516
             GSF C     C+ GY  + D  C + DEC    H C    LC NT G   C        
Sbjct: 740  LGSFHCYKALTCEPGY-ALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYC-------- 790

Query: 517  NGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLP 576
                 +  C DG               P+G    +C  DI+EC+     C    +CIN  
Sbjct: 791  ---QARQRCMDGFLQD-----------PEG----NC-VDINECTSLSEPCRPGFSCINTV 831

Query: 577  GWYHCE-----CRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCP 631
            G Y C+     C  GYH     S  G  C D++EC TG H C    +C NL G Y C C 
Sbjct: 832  GSYTCQRNPLICARGYH----ASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCK 887

Query: 632  HGKNCTGDCIHDGKVKHNGQIWVLENDRCS----------VCSCQNGFVMCR-RMVCDCE 680
             G     D    G +  N + W      C            CSC +GF++      C+  
Sbjct: 888  AG--FQRDAFGRGCIDVN-ECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDV 944

Query: 681  NPTVDLFCCPECDPRLSS-QCLHQNGETLYNSGDTW--VQNCQQCRCLQGEVDCWPLP-- 735
            N      C  EC     S QC  + G  L   G T   +  C Q   +     C  +P  
Sbjct: 945  NECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGS 1004

Query: 736  --CPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTC 773
              C   E  +++      C     D C   T      +TC
Sbjct: 1005 YQCACPEQGYTMTANGRSCKD--VDECALGTHNCSEAETC 1042



 Score =  136 bits (343), Expect = 7e-32
 Identities = 93/303 (30%), Positives = 134/303 (44%), Gaps = 76/303 (25%)

Query: 388  SHSC-----CKVCKGYDFCSERHNCMENSI------CRNLNDRAVCS--CRDGFRALR-- 432
            +H+C     C+  KG  +C  R  CM+  +      C ++N+    S  CR GF  +   
Sbjct: 772  THTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTV 831

Query: 433  -------------------EDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYI 473
                               +D   C D++EC  G H C E  +C N PGS+ C CK G+ 
Sbjct: 832  GSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQ 891

Query: 474  RIDDY--SCTEHDECITN-----QHNCDENALCFNTVGGHNCVCKPGY--TGNGTTCKAF 524
            R D +   C + +EC  +     QH C+      NT+G + C C  G+    +G  C+  
Sbjct: 892  R-DAFGRGCIDVNECWASPGRLCQHTCE------NTLGSYRCSCASGFLLAADGKRCEDV 944

Query: 525  -------CKDGCRNGGACIAANVCACPQGF----TGPSCETDIDECSDGF-VQCDSRANC 572
                   C   C N      +  C C QG+     G +C TDIDEC+ G  + C  R  C
Sbjct: 945  NECEAQRCSQECAN---IYGSYQCYCRQGYQLAEDGHTC-TDIDECAQGAGILCTFR--C 998

Query: 573  INLPGWYHCEC-RDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC--- 628
            +N+PG Y C C   GY      + +G SC+D+DEC  G H+C+    C N+ G + C   
Sbjct: 999  LNVPGSYQCACPEQGY----TMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRF 1054

Query: 629  RCP 631
             CP
Sbjct: 1055 ECP 1057



 Score =  121 bits (303), Expect = 3e-27
 Identities = 101/378 (26%), Positives = 149/378 (39%), Gaps = 104/378 (27%)

Query: 395  CKGYDFC-SERHNCMENSICRNLNDRAVC----SCRDGFRALREDNAYCEDIDECAEGRH 449
            C+  + C ++ H C     C N      C    +C  G+ AL++    CED+DECA G H
Sbjct: 717  CEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGY-ALKDGE--CEDVDECAMGTH 773

Query: 450  YCRENTMCVNTPGSFMC----ICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGG 505
             C+   +C NT GSF C     C  G+++  + +C + +EC +    C     C NTVG 
Sbjct: 774  TCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGS 833

Query: 506  HNC-----VCKPGY--TGNGTTC--------------------------KAFCKDGCRN- 531
            + C     +C  GY  + +GT C                          +  CK G +  
Sbjct: 834  YTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRD 893

Query: 532  --GGACIAANVC-ACPQGFTGPSCETDID----ECSDGFV------------QCDSR--- 569
              G  CI  N C A P      +CE  +      C+ GF+            +C+++   
Sbjct: 894  AFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCS 953

Query: 570  ANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCR 629
              C N+ G Y C CR GY      +  G +C DIDEC  G         C N+ G Y C 
Sbjct: 954  QECANIYGSYQCYCRQGY----QLAEDGHTCTDIDECAQGAGILCTFR-CLNVPGSYQCA 1008

Query: 630  CP--------HGKNC---------TGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVM- 671
            CP        +G++C         T +C  + +  HN    +  + RC    C   +V  
Sbjct: 1009 CPEQGYTMTANGRSCKDVDECALGTHNC-SEAETCHN----IQGSFRCLRFECPPNYVQV 1063

Query: 672  ----CRRMVC----DCEN 681
                C R  C    +C+N
Sbjct: 1064 SKTKCERTTCHDFLECQN 1081



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 93/398 (23%), Positives = 148/398 (37%), Gaps = 127/398 (31%)

Query: 482 EHDECITNQHNCDENALCFNTVGGHNCVCKPGYT--GNGTTCK----------------- 522
           + DEC+       ++ LC NTVG ++C C PG++   +G TC+                 
Sbjct: 604 DQDECLLLPGELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALK 662

Query: 523 -AFCK-------------DGCRNGGACI-------AANVCACPQGFT----GPSCETDID 557
             F +             + C++ G C         + +C+C  G+     G SCE DI+
Sbjct: 663 SEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCE-DIN 721

Query: 558 ECSDGFVQCDSRANCINLPGWYHC----ECRDGYHDNGMFSPSGESCEDIDECGTGRHSC 613
           EC      C    +C+N  G +HC     C  GY      +     CED+DEC  G H+C
Sbjct: 722 ECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGY------ALKDGECEDVDECAMGTHTC 775

Query: 614 ANDTICFNLDGGYDC----RCPHG--KNCTGDCIHDGKVKHNGQIWVLENDRCSVCS--C 665
               +C N  G + C    RC  G  ++  G+C+              + + C+  S  C
Sbjct: 776 QPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCV--------------DINECTSLSEPC 821

Query: 666 QNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETL----YNSGDTWVQNC-- 719
           + GF         C N TV  + C + +P + ++  H + +       N  +T V  C  
Sbjct: 822 RPGF--------SCIN-TVGSYTC-QRNPLICARGYHASDDGTKCVDVNECETGVHRCGE 871

Query: 720 -QQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMN 778
            Q C  L G   C                            C+A   R+   + C+D +N
Sbjct: 872 GQVCHNLPGSYRC---------------------------DCKAGFQRDAFGRGCID-VN 903

Query: 779 VVRFTGSSWIKHGTECTL----CQCKNGHICCSVDPQC 812
               +     +H  E TL    C C +G +  +   +C
Sbjct: 904 ECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRC 941



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 41/156 (26%), Positives = 63/156 (40%), Gaps = 16/156 (10%)

Query: 356  CVLYECKDQTMKLVESSGCPALDCPESHQITLS-HSCCKVCKGYDFCSERHNCMENSICR 414
            C    C  +   +  S  C    C + +Q+    H+C  +    D C++    +    C 
Sbjct: 947  CEAQRCSQECANIYGSYQCY---CRQGYQLAEDGHTCTDI----DECAQGAGILCTFRCL 999

Query: 415  NLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCI---CKTG 471
            N+     C+C +    +  +   C+D+DECA G H C E   C N  GSF C+   C   
Sbjct: 1000 NVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPN 1059

Query: 472  YIRIDDYSC---TEHD--ECITNQHNCDENALCFNT 502
            Y+++    C   T HD  EC  +        L F T
Sbjct: 1060 YVQVSKTKCERTTCHDFLECQNSPARITHYQLNFQT 1095



 Score = 34.7 bits (78), Expect = 0.37
 Identities = 30/110 (27%), Positives = 47/110 (42%), Gaps = 19/110 (17%)

Query: 639 DCIHDGKVKHN---GQIWVLENDRCSVCSCQNG-------FVMCRRMVCDCENPTVDLFC 688
           DC+  G V+     GQ + ++      CSC  G       F++C  +  +C    V    
Sbjct: 72  DCLQGGFVRGRVPAGQSYFVDFGSTE-CSCPPGGGKISCQFMLCPELPPNCIEAVVVADS 130

Query: 689 CPECDPRLSSQCLHQNGETLYNSGDT-WVQNCQQCRC--LQGEVDCWPLP 735
           CP+C       C+H   +  Y +G T  +  C+ C C    GE+ C+ LP
Sbjct: 131 CPQCG---QVGCVHAGHK--YAAGHTVHLPPCRACHCPDAGGELICYQLP 175


>gi|17978491 CD97 antigen isoform 1 precursor [Homo sapiens]
          Length = 835

 Score =  138 bits (347), Expect = 2e-32
 Identities = 80/246 (32%), Positives = 109/246 (44%), Gaps = 54/246 (21%)

Query: 407 CMENSICRNLNDRAVCSCRDGFRALRE----DNAYCEDIDECAE-GRHYCRENTMCVNTP 461
           C +NS C N      C C  GF +  E        C+DI+ECA   +  C + + C NT 
Sbjct: 30  CPQNSSCVNAT---ACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTE 86

Query: 462 GSFMCICKTGYIRID---------DYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKP 512
           GS+ C+C  GY  +          + +C + DEC  N   C     C NT+G + C C P
Sbjct: 87  GSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLP 146

Query: 513 GYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANC 572
           G+       K   +D                      P   TD++EC+ G   C S  +C
Sbjct: 147 GF-------KFIPED----------------------PKVCTDVNECTSGQNPCHSSTHC 177

Query: 573 INLPGWYHCECRDGYHD-----NGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYD 627
           +N  G Y C CR G+       NG   P+   CED+DEC +G+H C + T+CFN  G Y 
Sbjct: 178 LNNVGSYQCRCRPGWQPIPGSPNG---PNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYS 234

Query: 628 CRCPHG 633
           CRC  G
Sbjct: 235 CRCRPG 240



 Score =  110 bits (274), Expect = 7e-24
 Identities = 70/245 (28%), Positives = 100/245 (40%), Gaps = 52/245 (21%)

Query: 370 ESSGCPALDCPESHQITLSHSC----------------CKVCKGYDFCS--ERHNCMENS 411
           +S GC A  CP++     + +C                 + C   + C+   + +C + S
Sbjct: 22  DSRGC-ARWCPQNSSCVNATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFS 80

Query: 412 ICRNLNDRAVCSCRDGFRAL-------REDNAYCEDIDECAEGRHYCRENTMCVNTPGSF 464
            C N      C C  G+  +        E    C+D+DEC +    C+    CVNT GS+
Sbjct: 81  DCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSY 140

Query: 465 MCICKTGY--IRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCK 522
            C C  G+  I  D   CT+ +EC + Q+ C  +  C N VG + C C+PG+        
Sbjct: 141 TCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQP------ 194

Query: 523 AFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCE 582
                            +   P G     CE D+DECS G  QCDS   C N  G Y C 
Sbjct: 195 -----------------IPGSPNGPNNTVCE-DVDECSSGQHQCDSSTVCFNTVGSYSCR 236

Query: 583 CRDGY 587
           CR G+
Sbjct: 237 CRPGW 241



 Score = 32.0 bits (71), Expect = 2.4
 Identities = 16/54 (29%), Positives = 26/54 (48%), Gaps = 6/54 (11%)

Query: 394 VCKGYDFCSE-RHNCMENSICRNLNDRAVCSCRDGFRAL-----REDNAYCEDI 441
           VC+  D CS  +H C  +++C N      C CR G++        + +  CED+
Sbjct: 206 VCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDM 259


>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
          Length = 1200

 Score =  136 bits (342), Expect = 9e-32
 Identities = 151/583 (25%), Positives = 207/583 (35%), Gaps = 131/583 (22%)

Query: 264 RLDQCYCERTCTMKGTTYREF--ESWIDGCKNCTCLNGTI--QCETLICPNPDCPLKSAL 319
           R D+ Y   TC        +F      D   N  C++G +  +C+  +C    C L    
Sbjct: 197 RCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQ-GCNLLHGG 255

Query: 320 AYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDC 379
             V G    EC+    +QGR   E            CV Y             GC    C
Sbjct: 256 CTVPG----ECRCSYGWQGRFCDE------------CVPYP------------GCVHGSC 287

Query: 380 PESHQITLSHSCCKVC--KGYDFCSERHNCMENSICRNLN-DRAVCSCRDGFRALREDNA 436
            E  Q     +   +   K  ++C   H C     C N   D+  C+C DG+        
Sbjct: 288 VEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSG------ 341

Query: 437 YCEDIDECAEGRHYCRENT-----MCVNTPGSFMCICKTGYIRIDDYSCT-EHDECITNQ 490
                  C +  H C  N       C   P  F C C +G+      +C  + DEC +N 
Sbjct: 342 -----RNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGW---SGPTCALDIDECASNP 393

Query: 491 HNCDENALCFNTVGGHNCVCKPGYTGNGTTCKA---FCKDGCRNGGAC---IAANVCACP 544
             C     C + V G  C+C   +   G TC+     C+  C++GG C   +    C CP
Sbjct: 394 --CAAGGTCVDQVDGFECICPEQWV--GATCQLDVNDCRGQCQHGGTCKDLVNGYQCVCP 449

Query: 545 QGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE-DI 603
           +GF G  CE + DEC+     C S   C +L   +HC C  G+        SG  CE D+
Sbjct: 450 RGFGGRHCELERDECASS--PCHSGGLCEDLADGFHCHCPQGF--------SGPLCEVDV 499

Query: 604 DECGTGRHSCANDTICFNLDGGYDCRCPH---GKNCT--------GDC-IHD--GKVKHN 649
           D C      C N   C+NL+G Y C CP    GKNC+        G C + D  G     
Sbjct: 500 DLCEPS--PCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGP 557

Query: 650 GQIWVLENDRCSV---CSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGE 706
           G      +  C     C  Q G        C C++     +C    D  L   C  +NG 
Sbjct: 558 GMPGTAASGVCGPHGRCVSQPG----GNFSCICDSGFTGTYCHENIDDCLGQPC--RNGG 611

Query: 707 TLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQAD--- 763
           T  +  D +     +C C  G    W       E E      N+C P    DPC +    
Sbjct: 612 TCIDEVDAF-----RCFCPSG----W-------EGELCDTNPNDCLP----DPCHSRGRC 651

Query: 764 -TIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHIC 805
             + ND    C D      + G +      +C    C NG  C
Sbjct: 652 YDLVNDFYCACDD-----GWKGKTCHSREFQCDAYTCSNGGTC 689



 Score =  117 bits (292), Expect = 6e-26
 Identities = 117/463 (25%), Positives = 166/463 (35%), Gaps = 131/463 (28%)

Query: 407 CMENSICRNLNDRAVCSCRDGFRALREDNAYCE-DIDECAEGRHYCRENTMCVNTPGSFM 465
           C    +C +L D   C C  GF         CE D+D C      CR    C N  G + 
Sbjct: 469 CHSGGLCEDLADGFHCHCPQGF-----SGPLCEVDVDLCEPSP--CRNGARCYNLEGDYY 521

Query: 466 CICKTGYIRIDDY---------------SCTEHDECITNQHN----------CDENALCF 500
           C C       DD+               +C   D C ++             C  +  C 
Sbjct: 522 CACP------DDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCV 575

Query: 501 NTVGGH-NCVCKPGYTGNGTTCKAFCKD----GCRNGGACIA---ANVCACPQGFTGPSC 552
           +  GG+ +C+C  G+TG  T C     D     CRNGG CI    A  C CP G+ G  C
Sbjct: 576 SQPGGNFSCICDSGFTG--TYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC 633

Query: 553 ETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFS----------PSGESCED 602
           +T+ ++C      C SR  C +L   ++C C DG+      S           +G +C D
Sbjct: 634 DTNPNDCLPD--PCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYD 691

Query: 603 IDE--------------CGTGRHS------CANDTICFNLDGGYDCRCP---HGKNCT-- 637
             +              C   ++S      C N   C      + C C     G+ CT  
Sbjct: 692 SGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHN 751

Query: 638 -GDC----IHDGKVKHNGQIWVLENDRCSVCSCQNGFVM--CRRMVCDCENP--TVDLFC 688
             DC     ++G +  +G  W         C C  GF    CR  + +C++        C
Sbjct: 752 TNDCNPLPCYNGGICVDGVNWFR-------CECAPGFAGPDCRINIDECQSSPCAYGATC 804

Query: 689 CPE-------CDP-RLSSQCLHQNG--------ETLYNSGDTWVQNCQQCRCLQGEVDCW 732
             E       C P R   +C    G         T +  G +WV++C  CRCL G  DC 
Sbjct: 805 VDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCS 864

Query: 733 PLPCPDVECEFSILPE--NECCP-----------RCVTDPCQA 762
            + C    C  +  PE  +  CP           +C+  PC+A
Sbjct: 865 KVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEA 907



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 56/211 (26%), Positives = 81/211 (38%), Gaps = 31/211 (14%)

Query: 393 KVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCR 452
           K C   +F  + + C     C +  D   C+C  G++      + C      +   + C 
Sbjct: 669 KTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWK-----GSTCAVAKNSSCLPNPCV 723

Query: 453 ENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKP 512
               CV +  SF CIC+ G+   +  +CT H+    N   C    +C + V    C C P
Sbjct: 724 NGGTCVGSGASFSCICRDGW---EGRTCT-HNTNDCNPLPCYNGGICVDGVNWFRCECAP 779

Query: 513 GYTG-----NGTTCKAFCKDGCRNGGAC---IAANVCACPQGFTGPSCETDIDECSDGFV 564
           G+ G     N   C++     C  G  C   I    C+CP G  GP C+  I     GF 
Sbjct: 780 GFAGPDCRINIDECQS---SPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI-----GFG 831

Query: 565 Q-CDSRANCI-NLPGWYH----CECRDGYHD 589
           + C SR     +   W      C C DG  D
Sbjct: 832 RSCWSRGTPFPHGSSWVEDCNSCRCLDGRRD 862



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 16/55 (29%), Positives = 26/55 (47%)

Query: 272 RTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKC 326
           R+C  +GT +    SW++ C +C CL+G   C  + C    C L      +  +C
Sbjct: 832 RSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQC 886


>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
          Length = 601

 Score =  135 bits (340), Expect = 2e-31
 Identities = 119/387 (30%), Positives = 157/387 (40%), Gaps = 86/387 (22%)

Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
           C+G   C ++        CR+  D  VCSC  G++ L  D   CED++EC  G H CR  
Sbjct: 180 CRGGGPCKQQ--------CRDTGDEVVCSCFVGYQLL-SDGVSCEDVNECITGSHSCRLG 230

Query: 455 TMCVNTPGSFMC----ICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVC 510
             C+NT GSF C     C TGY   +D SC + DEC +  HNC  + +C NT+G   C  
Sbjct: 231 ESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRP 290

Query: 511 KPGYTGNGTTCKA-FCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSR 569
           K         CK+ F +D   N   CI                  DI+EC      C   
Sbjct: 291 K-------LQCKSGFIQDALGN---CI------------------DINECLSISAPCPIG 322

Query: 570 ANCINLPGWYHCE-----CRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDG 624
             CIN  G Y C+     C  GYH N      G  C D+DEC      C     C N  G
Sbjct: 323 HTCINTEGSYTCQKNVPNCGRGYHLN----EEGTRCVDVDECAPPAEPCGKGHRCVNSPG 378

Query: 625 GYDCRCPHGKNCTG---DCIHDGKV-KHNGQI--WVLENDRCS-VCSCQNGFVMCRRMVC 677
            + C C  G    G    C+   +  ++ G++     EN   S +CSC  GF +      
Sbjct: 379 SFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRL------ 432

Query: 678 DCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGE--VDCWPLP 735
                +VD   C + +   SS C  Q    +Y S         QC C +G    D   + 
Sbjct: 433 -----SVDGRSCEDINECSSSPC-SQECANVYGS--------YQCYCRRGYQLSDVDGVT 478

Query: 736 CPDV-ECEFSILPE--NECCPRCVTDP 759
           C D+ EC    LP   + C  RC+  P
Sbjct: 479 CEDIDEC---ALPTGGHICSYRCINIP 502



 Score =  135 bits (339), Expect = 2e-31
 Identities = 119/411 (28%), Positives = 173/411 (42%), Gaps = 101/411 (24%)

Query: 268 CYCERTCTMKGTTYREFESWIDGCKNC----TCLN--GTIQCETLICPNPDCPLKSALAY 321
           C+        G +  +    I G  +C    +C+N  G+ +C+       D    +    
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQR------DSSCGTGYEL 254

Query: 322 VDGKCCK---ECKS---------ICQ-----FQGRTYFEGERNTVYSSSGVCV-LYECKD 363
            +   CK   EC+S         ICQ     F+ R   + +   +  + G C+ + EC  
Sbjct: 255 TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINEC-- 312

Query: 364 QTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCS 423
               L  S+ CP           + H+C      Y        C +N          V +
Sbjct: 313 ----LSISAPCP-----------IGHTCINTEGSY-------TCQKN----------VPN 340

Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYS--CT 481
           C  G+  L E+   C D+DECA     C +   CVN+PGSF C CKTGY   D  S  C 
Sbjct: 341 CGRGYH-LNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY-FDGISRMCV 398

Query: 482 EHDECITNQHN-CDENALCFNTVGGHNCVCKPGY--TGNGTTCKAF-------CKDGCRN 531
           + +EC       C     C NT+G + C C  G+  + +G +C+         C   C N
Sbjct: 399 DVNECQRYPGRLCGHK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECAN 456

Query: 532 GGACIAANVCACPQGF-----TGPSCETDIDECS--DGFVQCDSRANCINLPGWYHCEC- 583
                 +  C C +G+      G +CE DIDEC+   G   C  R  CIN+PG + C C 
Sbjct: 457 ---VYGSYQCYCRRGYQLSDVDGVTCE-DIDECALPTGGHICSYR--CINIPGSFQCSCP 510

Query: 584 RDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC---RCP 631
             GY      +P+G +C+DIDEC TG H+C+ +  CFN+ GG+ C    CP
Sbjct: 511 SSGYR----LAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 49/135 (36%), Positives = 64/135 (47%), Gaps = 19/135 (14%)

Query: 524 FCKDGCRNGGACIA-------ANVCACPQGF----TGPSCETDIDECSDGFVQCDSRANC 572
           +  D CR GG C           VC+C  G+     G SCE D++EC  G   C    +C
Sbjct: 175 YLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCE-DVNECITGSHSCRLGESC 233

Query: 573 INLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCR--- 629
           IN  G + C+ RD     G       SC+DIDEC +G H+C  D IC N  G + CR   
Sbjct: 234 INTVGSFRCQ-RDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292

Query: 630 -CPHG--KNCTGDCI 641
            C  G  ++  G+CI
Sbjct: 293 QCKSGFIQDALGNCI 307


>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
          Length = 566

 Score =  135 bits (340), Expect = 2e-31
 Identities = 119/387 (30%), Positives = 157/387 (40%), Gaps = 86/387 (22%)

Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
           C+G   C ++        CR+  D  VCSC  G++ L  D   CED++EC  G H CR  
Sbjct: 180 CRGGGPCKQQ--------CRDTGDEVVCSCFVGYQLL-SDGVSCEDVNECITGSHSCRLG 230

Query: 455 TMCVNTPGSFMC----ICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVC 510
             C+NT GSF C     C TGY   +D SC + DEC +  HNC  + +C NT+G   C  
Sbjct: 231 ESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRP 290

Query: 511 KPGYTGNGTTCKA-FCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSR 569
           K         CK+ F +D   N   CI                  DI+EC      C   
Sbjct: 291 K-------LQCKSGFIQDALGN---CI------------------DINECLSISAPCPIG 322

Query: 570 ANCINLPGWYHCE-----CRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDG 624
             CIN  G Y C+     C  GYH N      G  C D+DEC      C     C N  G
Sbjct: 323 HTCINTEGSYTCQKNVPNCGRGYHLN----EEGTRCVDVDECAPPAEPCGKGHRCVNSPG 378

Query: 625 GYDCRCPHGKNCTG---DCIHDGKV-KHNGQI--WVLENDRCS-VCSCQNGFVMCRRMVC 677
            + C C  G    G    C+   +  ++ G++     EN   S +CSC  GF +      
Sbjct: 379 SFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRL------ 432

Query: 678 DCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGE--VDCWPLP 735
                +VD   C + +   SS C  Q    +Y S         QC C +G    D   + 
Sbjct: 433 -----SVDGRSCEDINECSSSPC-SQECANVYGS--------YQCYCRRGYQLSDVDGVT 478

Query: 736 CPDV-ECEFSILPE--NECCPRCVTDP 759
           C D+ EC    LP   + C  RC+  P
Sbjct: 479 CEDIDEC---ALPTGGHICSYRCINIP 502



 Score =  135 bits (339), Expect = 2e-31
 Identities = 119/411 (28%), Positives = 173/411 (42%), Gaps = 101/411 (24%)

Query: 268 CYCERTCTMKGTTYREFESWIDGCKNC----TCLN--GTIQCETLICPNPDCPLKSALAY 321
           C+        G +  +    I G  +C    +C+N  G+ +C+       D    +    
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQR------DSSCGTGYEL 254

Query: 322 VDGKCCK---ECKS---------ICQ-----FQGRTYFEGERNTVYSSSGVCV-LYECKD 363
            +   CK   EC+S         ICQ     F+ R   + +   +  + G C+ + EC  
Sbjct: 255 TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINEC-- 312

Query: 364 QTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCS 423
               L  S+ CP           + H+C      Y        C +N          V +
Sbjct: 313 ----LSISAPCP-----------IGHTCINTEGSY-------TCQKN----------VPN 340

Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYS--CT 481
           C  G+  L E+   C D+DECA     C +   CVN+PGSF C CKTGY   D  S  C 
Sbjct: 341 CGRGYH-LNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY-FDGISRMCV 398

Query: 482 EHDECITNQHN-CDENALCFNTVGGHNCVCKPGY--TGNGTTCKAF-------CKDGCRN 531
           + +EC       C     C NT+G + C C  G+  + +G +C+         C   C N
Sbjct: 399 DVNECQRYPGRLCGHK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECAN 456

Query: 532 GGACIAANVCACPQGF-----TGPSCETDIDECS--DGFVQCDSRANCINLPGWYHCEC- 583
                 +  C C +G+      G +CE DIDEC+   G   C  R  CIN+PG + C C 
Sbjct: 457 ---VYGSYQCYCRRGYQLSDVDGVTCE-DIDECALPTGGHICSYR--CINIPGSFQCSCP 510

Query: 584 RDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC---RCP 631
             GY      +P+G +C+DIDEC TG H+C+ +  CFN+ GG+ C    CP
Sbjct: 511 SSGYR----LAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 49/135 (36%), Positives = 64/135 (47%), Gaps = 19/135 (14%)

Query: 524 FCKDGCRNGGACIA-------ANVCACPQGF----TGPSCETDIDECSDGFVQCDSRANC 572
           +  D CR GG C           VC+C  G+     G SCE D++EC  G   C    +C
Sbjct: 175 YLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCE-DVNECITGSHSCRLGESC 233

Query: 573 INLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCR--- 629
           IN  G + C+ RD     G       SC+DIDEC +G H+C  D IC N  G + CR   
Sbjct: 234 INTVGSFRCQ-RDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292

Query: 630 -CPHG--KNCTGDCI 641
            C  G  ++  G+CI
Sbjct: 293 QCKSGFIQDALGNCI 307


>gi|34734066 fibulin 1 isoform D [Homo sapiens]
          Length = 703

 Score =  135 bits (340), Expect = 2e-31
 Identities = 119/387 (30%), Positives = 157/387 (40%), Gaps = 86/387 (22%)

Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
           C+G   C ++        CR+  D  VCSC  G++ L  D   CED++EC  G H CR  
Sbjct: 180 CRGGGPCKQQ--------CRDTGDEVVCSCFVGYQLL-SDGVSCEDVNECITGSHSCRLG 230

Query: 455 TMCVNTPGSFMC----ICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVC 510
             C+NT GSF C     C TGY   +D SC + DEC +  HNC  + +C NT+G   C  
Sbjct: 231 ESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRP 290

Query: 511 KPGYTGNGTTCKA-FCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSR 569
           K         CK+ F +D   N   CI                  DI+EC      C   
Sbjct: 291 K-------LQCKSGFIQDALGN---CI------------------DINECLSISAPCPIG 322

Query: 570 ANCINLPGWYHCE-----CRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDG 624
             CIN  G Y C+     C  GYH N      G  C D+DEC      C     C N  G
Sbjct: 323 HTCINTEGSYTCQKNVPNCGRGYHLN----EEGTRCVDVDECAPPAEPCGKGHRCVNSPG 378

Query: 625 GYDCRCPHGKNCTG---DCIHDGKV-KHNGQI--WVLENDRCS-VCSCQNGFVMCRRMVC 677
            + C C  G    G    C+   +  ++ G++     EN   S +CSC  GF +      
Sbjct: 379 SFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRL------ 432

Query: 678 DCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGE--VDCWPLP 735
                +VD   C + +   SS C  Q    +Y S         QC C +G    D   + 
Sbjct: 433 -----SVDGRSCEDINECSSSPC-SQECANVYGS--------YQCYCRRGYQLSDVDGVT 478

Query: 736 CPDV-ECEFSILPE--NECCPRCVTDP 759
           C D+ EC    LP   + C  RC+  P
Sbjct: 479 CEDIDEC---ALPTGGHICSYRCINIP 502



 Score =  135 bits (339), Expect = 2e-31
 Identities = 119/411 (28%), Positives = 173/411 (42%), Gaps = 101/411 (24%)

Query: 268 CYCERTCTMKGTTYREFESWIDGCKNC----TCLN--GTIQCETLICPNPDCPLKSALAY 321
           C+        G +  +    I G  +C    +C+N  G+ +C+       D    +    
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQR------DSSCGTGYEL 254

Query: 322 VDGKCCK---ECKS---------ICQ-----FQGRTYFEGERNTVYSSSGVCV-LYECKD 363
            +   CK   EC+S         ICQ     F+ R   + +   +  + G C+ + EC  
Sbjct: 255 TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINEC-- 312

Query: 364 QTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCS 423
               L  S+ CP           + H+C      Y        C +N          V +
Sbjct: 313 ----LSISAPCP-----------IGHTCINTEGSY-------TCQKN----------VPN 340

Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYS--CT 481
           C  G+  L E+   C D+DECA     C +   CVN+PGSF C CKTGY   D  S  C 
Sbjct: 341 CGRGYH-LNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY-FDGISRMCV 398

Query: 482 EHDECITNQHN-CDENALCFNTVGGHNCVCKPGY--TGNGTTCKAF-------CKDGCRN 531
           + +EC       C     C NT+G + C C  G+  + +G +C+         C   C N
Sbjct: 399 DVNECQRYPGRLCGHK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECAN 456

Query: 532 GGACIAANVCACPQGF-----TGPSCETDIDECS--DGFVQCDSRANCINLPGWYHCEC- 583
                 +  C C +G+      G +CE DIDEC+   G   C  R  CIN+PG + C C 
Sbjct: 457 ---VYGSYQCYCRRGYQLSDVDGVTCE-DIDECALPTGGHICSYR--CINIPGSFQCSCP 510

Query: 584 RDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC---RCP 631
             GY      +P+G +C+DIDEC TG H+C+ +  CFN+ GG+ C    CP
Sbjct: 511 SSGYR----LAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 49/135 (36%), Positives = 64/135 (47%), Gaps = 19/135 (14%)

Query: 524 FCKDGCRNGGACIA-------ANVCACPQGF----TGPSCETDIDECSDGFVQCDSRANC 572
           +  D CR GG C           VC+C  G+     G SCE D++EC  G   C    +C
Sbjct: 175 YLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCE-DVNECITGSHSCRLGESC 233

Query: 573 INLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCR--- 629
           IN  G + C+ RD     G       SC+DIDEC +G H+C  D IC N  G + CR   
Sbjct: 234 INTVGSFRCQ-RDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292

Query: 630 -CPHG--KNCTGDCI 641
            C  G  ++  G+CI
Sbjct: 293 QCKSGFIQDALGNCI 307


>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
          Length = 683

 Score =  135 bits (340), Expect = 2e-31
 Identities = 119/387 (30%), Positives = 157/387 (40%), Gaps = 86/387 (22%)

Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
           C+G   C ++        CR+  D  VCSC  G++ L  D   CED++EC  G H CR  
Sbjct: 180 CRGGGPCKQQ--------CRDTGDEVVCSCFVGYQLL-SDGVSCEDVNECITGSHSCRLG 230

Query: 455 TMCVNTPGSFMC----ICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVC 510
             C+NT GSF C     C TGY   +D SC + DEC +  HNC  + +C NT+G   C  
Sbjct: 231 ESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRP 290

Query: 511 KPGYTGNGTTCKA-FCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSR 569
           K         CK+ F +D   N   CI                  DI+EC      C   
Sbjct: 291 K-------LQCKSGFIQDALGN---CI------------------DINECLSISAPCPIG 322

Query: 570 ANCINLPGWYHCE-----CRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDG 624
             CIN  G Y C+     C  GYH N      G  C D+DEC      C     C N  G
Sbjct: 323 HTCINTEGSYTCQKNVPNCGRGYHLN----EEGTRCVDVDECAPPAEPCGKGHRCVNSPG 378

Query: 625 GYDCRCPHGKNCTG---DCIHDGKV-KHNGQI--WVLENDRCS-VCSCQNGFVMCRRMVC 677
            + C C  G    G    C+   +  ++ G++     EN   S +CSC  GF +      
Sbjct: 379 SFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRL------ 432

Query: 678 DCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGE--VDCWPLP 735
                +VD   C + +   SS C  Q    +Y S         QC C +G    D   + 
Sbjct: 433 -----SVDGRSCEDINECSSSPC-SQECANVYGS--------YQCYCRRGYQLSDVDGVT 478

Query: 736 CPDV-ECEFSILPE--NECCPRCVTDP 759
           C D+ EC    LP   + C  RC+  P
Sbjct: 479 CEDIDEC---ALPTGGHICSYRCINIP 502



 Score =  135 bits (339), Expect = 2e-31
 Identities = 119/411 (28%), Positives = 173/411 (42%), Gaps = 101/411 (24%)

Query: 268 CYCERTCTMKGTTYREFESWIDGCKNC----TCLN--GTIQCETLICPNPDCPLKSALAY 321
           C+        G +  +    I G  +C    +C+N  G+ +C+       D    +    
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQR------DSSCGTGYEL 254

Query: 322 VDGKCCK---ECKS---------ICQ-----FQGRTYFEGERNTVYSSSGVCV-LYECKD 363
            +   CK   EC+S         ICQ     F+ R   + +   +  + G C+ + EC  
Sbjct: 255 TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINEC-- 312

Query: 364 QTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCS 423
               L  S+ CP           + H+C      Y        C +N          V +
Sbjct: 313 ----LSISAPCP-----------IGHTCINTEGSY-------TCQKN----------VPN 340

Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYS--CT 481
           C  G+  L E+   C D+DECA     C +   CVN+PGSF C CKTGY   D  S  C 
Sbjct: 341 CGRGYH-LNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY-FDGISRMCV 398

Query: 482 EHDECITNQHN-CDENALCFNTVGGHNCVCKPGY--TGNGTTCKAF-------CKDGCRN 531
           + +EC       C     C NT+G + C C  G+  + +G +C+         C   C N
Sbjct: 399 DVNECQRYPGRLCGHK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECAN 456

Query: 532 GGACIAANVCACPQGF-----TGPSCETDIDECS--DGFVQCDSRANCINLPGWYHCEC- 583
                 +  C C +G+      G +CE DIDEC+   G   C  R  CIN+PG + C C 
Sbjct: 457 ---VYGSYQCYCRRGYQLSDVDGVTCE-DIDECALPTGGHICSYR--CINIPGSFQCSCP 510

Query: 584 RDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC---RCP 631
             GY      +P+G +C+DIDEC TG H+C+ +  CFN+ GG+ C    CP
Sbjct: 511 SSGYR----LAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 49/135 (36%), Positives = 64/135 (47%), Gaps = 19/135 (14%)

Query: 524 FCKDGCRNGGACIA-------ANVCACPQGF----TGPSCETDIDECSDGFVQCDSRANC 572
           +  D CR GG C           VC+C  G+     G SCE D++EC  G   C    +C
Sbjct: 175 YLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCE-DVNECITGSHSCRLGESC 233

Query: 573 INLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCR--- 629
           IN  G + C+ RD     G       SC+DIDEC +G H+C  D IC N  G + CR   
Sbjct: 234 INTVGSFRCQ-RDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292

Query: 630 -CPHG--KNCTGDCI 641
            C  G  ++  G+CI
Sbjct: 293 QCKSGFIQDALGNCI 307


>gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens]
          Length = 814

 Score =  135 bits (339), Expect = 2e-31
 Identities = 151/603 (25%), Positives = 202/603 (33%), Gaps = 108/603 (17%)

Query: 272 RTCTMKGTTYREFESWI-DGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKEC 330
           R C+  G TY   E++  D C  C CL GTI C    CP   CP         G CC  C
Sbjct: 136 RGCSQNGQTYGNGETFSPDACTTCRCLEGTITCNQKPCPRGPCP-------EPGACCPHC 188

Query: 331 KSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHS 390
           K  C ++G+ Y EG   T  SSS  C+   C    ++ +    CP   CPE   +     
Sbjct: 189 KPGCDYEGQLYEEGV--TFLSSSNPCLQCTCLRSRVRCMALK-CPPSPCPEP--VLRPGH 243

Query: 391 CCKVCKGYDFCSERHNCMENS-----------ICRNLNDRAVCSCRD-----GFRALRED 434
           CC  C+G   C+E  +  E+            ICR L     C  R+      + A    
Sbjct: 244 CCPTCQG---CTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASLCPYPARPLP 300

Query: 435 NAYCEDIDEC-AEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCT----EHDECITN 489
              C   D C   GR +     +    P S  C C  G ++ +   C      H   I  
Sbjct: 301 GTCCPVCDGCFLNGREHRSGEPVGSGDPCSH-CRCANGSVQCEPLPCPPVPCRHPGKIPG 359

Query: 490 QHNCDENALCFNTVGGHNCVCKPGYT--GNGTTCKAFCKDG---CRNGGACIAANVCACP 544
           Q  C     C     GH    +  +     G   +  C+ G   C      +    CA P
Sbjct: 360 QC-CPVCDGC--EYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTP--CALP 414

Query: 545 QGFTG--PSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMF--------- 593
                  P+CE D +E ++G         C        C C+DG    G           
Sbjct: 415 ASGRQLCPACELDGEEFAEGVQWEPDGRPCTA------CVCQDGVPKCGAVLCPPAPCQH 468

Query: 594 --SPSGESCEDIDECGTGRHSCANDT----------ICFNLDGGYDCR---CPH------ 632
              P G  C   D C       AN             C   DG   C    CP       
Sbjct: 469 PTQPPGACCPSCDSCTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTTCARP 528

Query: 633 ----GKNCTG--DCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCD---CENPT 683
               G+ C    DCI + +V  +G+ +    D C  C CQ G   C+   C    C +P 
Sbjct: 529 QSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAHPL 588

Query: 684 VDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDVECEF 743
               C  +C         + +G    +  D     C+ CRCL G V C    C  + C  
Sbjct: 589 PGTCCPNDCSGCAFGGKEYPSGADFPHPSDP----CRLCRCLSGNVQCLARRCVPLPCPE 644

Query: 744 SILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGH 803
            +L   ECCP+C   P  A   R         E          +   G  C  C C +G 
Sbjct: 645 PVLLPGECCPQCPAAPAPAGCPRPGAAHARHQEY---------FSPPGDPCRRCLCLDGS 695

Query: 804 ICC 806
           + C
Sbjct: 696 VSC 698



 Score =  110 bits (276), Expect = 4e-24
 Identities = 142/577 (24%), Positives = 197/577 (34%), Gaps = 116/577 (20%)

Query: 274 CTMKGTTYREFESWI---DGCKNCTCLNGTIQCE----TLICPNPDCPLKSALAYVDGKC 326
           CT  G+ +   + W    D C+ C CL G IQC       +CP P  PL        G C
Sbjct: 251 CTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASLCPYPARPLP-------GTC 303

Query: 327 CKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQIT 386
           C  C   C   GR +  GE      S   C    C + +++  E   CP + C   H   
Sbjct: 304 CPVCDG-CFLNGREHRSGEP---VGSGDPCSHCRCANGSVQC-EPLPCPPVPC--RHPGK 356

Query: 387 LSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNA---------- 436
           +   CC VC G ++   ++   E    +       CSC+ G  +  E             
Sbjct: 357 IPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTPCALPAS 416

Query: 437 ------YCE-DIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITN 489
                  CE D +E AEG  +  +   C        C+C+ G  +     C     C   
Sbjct: 417 GRQLCPACELDGEEFAEGVQWEPDGRPCT------ACVCQDGVPKCGAVLCPPAP-C--- 466

Query: 490 QHNCDENALCFNTVGG---HNCVCKPG--YTGNGTTCKA-FCKDGCRNGGAC-IAANVCA 542
           QH       C  +      H+ V   G  +T   + C A  C+DG             CA
Sbjct: 467 QHPTQPPGACCPSCDSCTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTTCA 526

Query: 543 CPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCED 602
            PQ   G  C    D   +  V  D  +          C C++G+            C+ 
Sbjct: 527 RPQSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGH----------AHCQP 576

Query: 603 IDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSV 662
                     C        L G   C CP+  +C+G C   GK   +G  +   +D C +
Sbjct: 577 --------RPCPRAPCAHPLPG--TC-CPN--DCSG-CAFGGKEYPSGADFPHPSDPCRL 622

Query: 663 CSCQNGFVMCRRMVC---DCENPTV-DLFCCPECD--------PRL-SSQCLHQNGETLY 709
           C C +G V C    C    C  P +    CCP+C         PR  ++   HQ  E   
Sbjct: 623 CRCLSGNVQCLARRCVPLPCPEPVLLPGECCPQCPAAPAPAGCPRPGAAHARHQ--EYFS 680

Query: 710 NSGDTWVQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDI 769
             GD     C++C CL G V C  LPCP   C      +  CCP C              
Sbjct: 681 PPGDP----CRRCLCLDGSVSCQRLPCPPAPCAHP--RQGPCCPSC-------------- 720

Query: 770 TKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHICC 806
              CL +      +G  +      C LC C  G + C
Sbjct: 721 -DGCLYQGKEFA-SGERFPSPTAACHLCLCWEGSVSC 755



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 88/321 (27%), Positives = 114/321 (35%), Gaps = 58/321 (18%)

Query: 508 CVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCD 567
           CVC+ G    G         GC   G           + F+  +C T    C +G + C+
Sbjct: 117 CVCQDGAAHCGPQAHLPHCRGCSQNGQTYGNG-----ETFSPDACTTC--RCLEGTITCN 169

Query: 568 S----RANCINLPGWYHCECRDG-------YHDNGMFSPSGESCEDIDECGTGRHSC--- 613
                R  C   PG     C+ G       Y +   F  S   C     C   R  C   
Sbjct: 170 QKPCPRGPCPE-PGACCPHCKPGCDYEGQLYEEGVTFLSSSNPCLQCT-CLRSRVRCMAL 227

Query: 614 -ANDTICFN--LDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFV 670
               + C    L  G+ C       C G C   G    +GQ W    D C +C C  G +
Sbjct: 228 KCPPSPCPEPVLRPGHCC-----PTCQG-CTEGGSHWEHGQEWTTPGDPCRICRCLEGHI 281

Query: 671 MCRRMVCD--CENPTVDL--FCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQ 726
            CR+  C   C  P   L   CCP CD    +   H++GE +  SGD     C  CRC  
Sbjct: 282 QCRQRECASLCPYPARPLPGTCCPVCDGCFLNGREHRSGEPV-GSGDP----CSHCRCAN 336

Query: 727 GEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTC-LDEMNVVRFTGS 785
           G V C PLPCP V C        +CCP C  D C+    +    +T  L E  +      
Sbjct: 337 GSVQCEPLPCPPVPCRHPGKIPGQCCPVC--DGCEYQGHQYQSQETFRLQERGL------ 388

Query: 786 SWIKHGTECTLCQCKNGHICC 806
                   C  C C+ G + C
Sbjct: 389 --------CVRCSCQAGEVSC 401



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 137/602 (22%), Positives = 186/602 (30%), Gaps = 164/602 (27%)

Query: 234 FHGLVQKIMELQDILAKTSAKLSRAEQRMNRLDQCYCERT---CTMKGTTYREFESWI-D 289
           +H L + +  L+  + +   +    + R+ +L+ C C      C   G  + E   W  D
Sbjct: 53  WHPLREWLGRLEAAVMELREQNKDLQTRVRQLESCECHPASPQCWGLGRAWPEGARWEPD 112

Query: 290 GCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTV 349
            C  C C +G   C     P    P               C+  C   G+TY  GE    
Sbjct: 113 ACTACVCQDGAAHCG----PQAHLP--------------HCRG-CSQNGQTYGNGET--- 150

Query: 350 YSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCK-GYDFCSERHNCM 408
             S   C    C + T+   +   CP   CPE        +CC  CK G D+        
Sbjct: 151 -FSPDACTTCRCLEGTITCNQKP-CPRGPCPEPG------ACCPHCKPGCDY-------- 194

Query: 409 ENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCIC 468
                                                EG+ Y    T   ++     C C
Sbjct: 195 -------------------------------------EGQLYEEGVTFLSSSNPCLQCTC 217

Query: 469 KTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDG 528
               +R     C            C E  L            +PG+      C   C+ G
Sbjct: 218 LRSRVRCMALKCPPSP--------CPEPVL------------RPGH------CCPTCQ-G 250

Query: 529 CRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINL--------PGWYH 580
           C  GG+          Q +T P     I  C +G +QC  R  C +L        PG   
Sbjct: 251 CTEGGSHWEHG-----QEWTTPGDPCRICRCLEGHIQCRQR-ECASLCPYPARPLPGTC- 303

Query: 581 CECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDC 640
           C   DG   NG    SGE     D C   R  CAN ++           C H     G C
Sbjct: 304 CPVCDGCFLNGREHRSGEPVGSGDPCSHCR--CANGSVQCEPLPCPPVPCRHPGKIPGQC 361

Query: 641 --IHDGKVKHNGQIWVLENDR------CSVCSCQNGFVMCRRMVCD---CENPTVDLFCC 689
             + DG      Q    E  R      C  CSCQ G V C    C    C  P      C
Sbjct: 362 CPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTPCALPASGRQLC 421

Query: 690 PECDPRLSSQCLHQNGETLYNSGDTWVQN---CQQCRCLQGEVDCWPLPCPDVECEFSIL 746
           P C+          +GE  +  G  W  +   C  C C  G   C  + CP   C+    
Sbjct: 422 PACE---------LDGEE-FAEGVQWEPDGRPCTACVCQDGVPKCGAVLCPPAPCQHPTQ 471

Query: 747 PENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHICC 806
           P   CCP C  D C   +               V   G ++    + C  C C++G + C
Sbjct: 472 PPGACCPSC--DSCTYHS--------------QVYANGQNFTDADSPCHACHCQDGTVTC 515

Query: 807 SV 808
           S+
Sbjct: 516 SL 517



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 117/506 (23%), Positives = 163/506 (32%), Gaps = 123/506 (24%)

Query: 274 CTMKGTTYREFESWIDG--CKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECK 331
           C + G  +R  E    G  C +C C NG++QCE L CP   C        + G+CC  C 
Sbjct: 310 CFLNGREHRSGEPVGSGDPCSHCRCANGSVQCEPLPCPPVPCRHPGK---IPGQCCPVCD 366

Query: 332 SICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDC--PESHQITLSH 389
             C++QG  Y + +        G+CV   C+   +   E   CP   C  P S       
Sbjct: 367 G-CEYQGHQY-QSQETFRLQERGLCVRCSCQAGEVSCEEQE-CPVTPCALPAS-----GR 418

Query: 390 SCCKVCK--GYDFCSERHNCMENSICRNLNDRAVCSCRDGF--------------RALRE 433
             C  C+  G +F        +   C        C C+DG                  + 
Sbjct: 419 QLCPACELDGEEFAEGVQWEPDGRPC------TACVCQDGVPKCGAVLCPPAPCQHPTQP 472

Query: 434 DNAYCEDIDEC-------AEGRHYCRENTMCVNTPGSFMCICKTGYIRID---------- 476
             A C   D C       A G+++   ++ C        C C+ G +             
Sbjct: 473 PGACCPSCDSCTYHSQVYANGQNFTDADSPC------HACHCQDGTVTCSLVDCPPTTCA 526

Query: 477 ------DYSCTEHDECITNQ----------HNCDENALCFNTVGGHNCVCKP------GY 514
                    C    +CI  +          H  D    C    G  +C  +P       +
Sbjct: 527 RPQSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAH 586

Query: 515 TGNGTTCKAFCKDGCRNGGACIAANVCACPQG--FTGPSCETDIDECSDGFVQCDSRANC 572
              GT C   C  GC  GG          P G  F  PS    +  C  G VQC +R  C
Sbjct: 587 PLPGTCCPNDCS-GCAFGGK-------EYPSGADFPHPSDPCRLCRCLSGNVQCLAR-RC 637

Query: 573 INLP--------GWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDG 624
           + LP        G    +C       G   P        +        C     C  LDG
Sbjct: 638 VPLPCPEPVLLPGECCPQCPAAPAPAGCPRPGAAHARHQEYFSPPGDPCRR---CLCLDG 694

Query: 625 GYDCR--------CPHGK------NCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFV 670
              C+        C H +      +C G C++ GK   +G+ +      C +C C  G V
Sbjct: 695 SVSCQRLPCPPAPCAHPRQGPCCPSCDG-CLYQGKEFASGERFPSPTAACHLCLCWEGSV 753

Query: 671 MCRRMVCD---CENPTVDLFCCPECD 693
            C    C    C  P     CCP+CD
Sbjct: 754 SCEPKACAPALCPFPARG-DCCPDCD 778



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 68/261 (26%), Positives = 97/261 (37%), Gaps = 43/261 (16%)

Query: 559 CSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTI 618
           C DG   C  +A+   LP   HC    G   NG    +GE+    D C T R  C   TI
Sbjct: 119 CQDGAAHCGPQAH---LP---HCR---GCSQNGQTYGNGETFSP-DACTTCR--CLEGTI 166

Query: 619 CFNLDGGYDCRCPHG----KNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRR 674
             N        CP       +C   C ++G++   G  ++  ++ C  C+C    V C  
Sbjct: 167 TCNQKPCPRGPCPEPGACCPHCKPGCDYEGQLYEEGVTFLSSSNPCLQCTCLRSRVRCMA 226

Query: 675 MVCD---CENPTVDL-FCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVD 730
           + C    C  P +    CCP C          ++G+     GD     C+ CRCL+G + 
Sbjct: 227 LKCPPSPCPEPVLRPGHCCPTCQGCTEGGSHWEHGQEWTTPGDP----CRICRCLEGHIQ 282

Query: 731 CWPLPCPDVECEFSILP-ENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIK 789
           C    C  + C +   P    CCP C  D C                +N         + 
Sbjct: 283 CRQRECASL-CPYPARPLPGTCCPVC--DGCF---------------LNGREHRSGEPVG 324

Query: 790 HGTECTLCQCKNGHICCSVDP 810
            G  C+ C+C NG + C   P
Sbjct: 325 SGDPCSHCRCANGSVQCEPLP 345



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 48/176 (27%), Positives = 68/176 (38%), Gaps = 39/176 (22%)

Query: 274 CTMKGTTYREFESWI----DGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKE 329
           C   G  +   + +     D C+ C CL+G++ C+ L CP   C          G CC  
Sbjct: 665 CPRPGAAHARHQEYFSPPGDPCRRCLCLDGSVSCQRLPCPPAPCAHPR-----QGPCCPS 719

Query: 330 CKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSH 389
           C   C +QG+ +  GER    S +  C L  C + ++     +  PAL CP         
Sbjct: 720 CDG-CLYQGKEFASGER--FPSPTAACHLCLCWEGSVSCEPKACAPAL-CP----FPARG 771

Query: 390 SCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALR---EDNAYCEDID 442
            CC  C G     E H               + SCR G R  R   ++N YC  +D
Sbjct: 772 DCCPDCDG-----EGH--------------GIGSCRGGMRETRGLGQNNLYCPRVD 808


>gi|4557679 jagged 1 precursor [Homo sapiens]
          Length = 1218

 Score =  134 bits (338), Expect = 3e-31
 Identities = 140/524 (26%), Positives = 201/524 (38%), Gaps = 114/524 (21%)

Query: 288 IDGCKNCTCLNGTIQC----ETLICPNPDCPLKSALAYVDGKCCKECKSICQ------FQ 337
           ID C+   C NG  QC        C  P+          +GK C   K  C+        
Sbjct: 526 IDYCEPNPCQNGA-QCYNRASDYFCKCPED--------YEGKNCSHLKDHCRTTPCEVID 576

Query: 338 GRTYFEGERNTV----YSSSGVCVLY-ECKDQTMKLVESSGCPALDCPESHQITLSHSCC 392
             T      +T     Y SS VC  + +CK Q      S G    DC +    T  H   
Sbjct: 577 SCTVAMASNDTPEGVRYISSNVCGPHGKCKSQ------SGGKFTCDCNKGFTGTYCHENI 630

Query: 393 KVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCE-DIDECAEGRHYC 451
             C       E + C     C +  +   C C DG+     + AYCE +I++C++    C
Sbjct: 631 NDC-------ESNPCRNGGTCIDGVNSYKCICSDGW-----EGAYCETNINDCSQNP--C 676

Query: 452 RENTMCVNTPGSFMCICKTGYIRIDDYSCTEHD-ECITNQHNCDENALCFNTVGGHNCVC 510
                C +    F C CK G+      +C   D +C  ++  C+    C++      C+C
Sbjct: 677 HNGGTCRDLVNDFYCDCKNGW---KGKTCHSRDSQC--DEATCNNGGTCYDEGDAFKCMC 731

Query: 511 KPGYTGNGTTCK-----AFCKDGCRNGGACIAAN---VCACPQGFTGPSCETDIDECSDG 562
             G+   GTTC      +   + C NGG C+       C C +G+ GP C  + ++CS  
Sbjct: 732 PGGW--EGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPH 789

Query: 563 FVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE-DIDECGTGRHSCANDTICFN 621
              C +   C++   WY CEC  G+        +G  C  +I+EC +    CA    C +
Sbjct: 790 --PCYNSGTCVDGDNWYRCECAPGF--------AGPDCRININECQSS--PCAFGATCVD 837

Query: 622 LDGGYDCRCPHG------KNCTG-DCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRR 674
              GY C CP G      +  +G  CI  G V  +G  W   +D C+ C C NG + C +
Sbjct: 838 EINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKW---DDDCNTCQCLNGRIACSK 894

Query: 675 MVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPL 734
           +                C PR    CL   G +   SG       Q C  +  +  C+  
Sbjct: 895 V---------------WCGPR---PCLLHKGHSECPSG-------QSCIPILDD-QCFVH 928

Query: 735 PCPDV-ECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEM 777
           PC  V EC  S L   +   +C +D    D   N IT T   EM
Sbjct: 929 PCTGVGECRSSSLQPVK--TKCTSDSYYQDNCAN-ITFTFNKEM 969



 Score =  112 bits (280), Expect = 1e-24
 Identities = 113/448 (25%), Positives = 163/448 (36%), Gaps = 97/448 (21%)

Query: 407 CMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMC 466
           C+    C+N  +R  C C  GF      N    DID C      C+    C N    + C
Sbjct: 496 CLNGGHCQNEINRFQCLCPTGFSG----NLCQLDIDYCEPNP--CQNGAQCYNRASDYFC 549

Query: 467 ICKTGY-----IRIDDYS----CTEHDECIT--------------NQHNCDENALCFNTV 503
            C   Y       + D+     C   D C                + + C  +  C +  
Sbjct: 550 KCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQS 609

Query: 504 GGH-NCVCKPGYTGNGTTCKAFCKD----GCRNGGACIA---ANVCACPQGFTGPSCETD 555
           GG   C C  G+TG  T C     D     CRNGG CI    +  C C  G+ G  CET+
Sbjct: 610 GGKFTCDCNKGFTG--TYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETN 667

Query: 556 IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDID-ECGTGRHSCA 614
           I++CS     C +   C +L   ++C+C++G+         G++C   D +C     +C 
Sbjct: 668 INDCSQN--PCHNGGTCRDLVNDFYCDCKNGW--------KGKTCHSRDSQCDEA--TCN 715

Query: 615 NDTICFNLDGGYDCRCP---HGKNC----TGDCIHDGKVKHNGQIWVLENDRCSVCSCQN 667
           N   C++    + C CP    G  C       C+ +    HNG   V+ N     C C+ 
Sbjct: 716 NGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPN--PCHNGGTCVV-NGESFTCVCKE 772

Query: 668 GF--VMCRRMVCDCE-NPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRC 724
           G+   +C +   DC  +P  +   C +                    GD W     +C C
Sbjct: 773 GWEGPICAQNTNDCSPHPCYNSGTCVD--------------------GDNW----YRCEC 808

Query: 725 LQGEV--DCW--PLPCPDVECEFSILPENECCP-RCVTDPCQADTIRNDITKTCLDEMNV 779
             G    DC      C    C F     +E    RCV  P  +     +++      M  
Sbjct: 809 APGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGS 868

Query: 780 VRFTGSSWIKHGTECTLCQCKNGHICCS 807
           V   G+ W     +C  CQC NG I CS
Sbjct: 869 VIPDGAKW---DDDCNTCQCLNGRIACS 893



 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 104/394 (26%), Positives = 148/394 (37%), Gaps = 129/394 (32%)

Query: 391 CCKVCK------GYDFCSERHN--CMENSI---CRNLNDRAVCSCRDGFRALREDNAYCE 439
           C K C+      G+  C +  N  CME  +   C     R  CS + G   L  D   C 
Sbjct: 196 CNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGD---CR 252

Query: 440 DIDECAEGRH--YCRENTMCVNTPGS--------FMCICKT---GYIRIDDYS-CTEHDE 485
               C  G    YC +   C+  PG         + C+C+T   G +   D + C  H  
Sbjct: 253 ----CQYGWQGLYCDK---CIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQP 305

Query: 486 CITNQHNCDENALCFNT-VGGHNCVCKPGYTG-NGTTCKAFC-KDGCRNGGACIAANV-- 540
           C+           C NT    + C C  GY+G N    +  C  D C N G+C   ++  
Sbjct: 306 CLNG-------GTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGF 358

Query: 541 -CACPQGFTGPSCETDIDECS--------------DGF---------------------- 563
            C C  G+TGP+C T+ID+CS              +GF                      
Sbjct: 359 ECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEA 418

Query: 564 VQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE-DIDECGTGRHSCANDTICFNL 622
             C +  +C NL   Y+C+C  G+         G++C+ +I++C      C ND  C +L
Sbjct: 419 KPCVNAKSCKNLIASYYCDCLPGW--------MGQNCDININDC---LGQCQNDASCRDL 467

Query: 623 DGGYDCRCP---HGKNCTGD--------CIHDGKVKH-------------NGQIWVLEND 658
             GY C CP    G +C  D        C++ G  ++             +G +  L+ D
Sbjct: 468 VNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDID 527

Query: 659 RCSVCSCQNGFVMCRRMVCDCENPTVDLFC-CPE 691
            C    CQNG          C N   D FC CPE
Sbjct: 528 YCEPNPCQNG--------AQCYNRASDYFCKCPE 553



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 21/65 (32%), Positives = 29/65 (44%), Gaps = 10/65 (15%)

Query: 272 RTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLIC-PNP--------DCPL-KSALAY 321
           R C   G+   +   W D C  C CLNG I C  + C P P        +CP  +S +  
Sbjct: 861 RPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPI 920

Query: 322 VDGKC 326
           +D +C
Sbjct: 921 LDDQC 925


>gi|46249414 latent transforming growth factor beta binding protein 1
            isoform LTBP-1L [Homo sapiens]
          Length = 1722

 Score =  130 bits (328), Expect = 4e-30
 Identities = 129/442 (29%), Positives = 170/442 (38%), Gaps = 62/442 (14%)

Query: 333  ICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCC 392
            IC ++G  + E +R  V       V + C     +  E S      CP     +   + C
Sbjct: 900  IC-YEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCI--CPAGFMASEEGTNC 956

Query: 393  ---KVCKGYDFCSERHNCMENSICRNLNDRAVCS-CRDGFRALREDNAYCEDIDECAEGR 448
                 C   D C E H       C N      C  C  G+R  +     CEDIDEC    
Sbjct: 957  IDVDECLRPDVCGEGH-------CVNTVGAFRCEYCDSGYRMTQRGR--CEDIDECLNPS 1007

Query: 449  HYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNC 508
                E   CVN+PGS+ C+  T   R  +  C + DEC+  + N   N  C N  G + C
Sbjct: 1008 TCPDEQ--CVNSPGSYQCVPCTEGFRGWNGQCLDVDECL--EPNVCANGDCSNLEGSYMC 1063

Query: 509  VCKPGYTGNGTTCKAFCK--DGCRNGGACIAANV--------CACPQGF----TGPSCET 554
             C  GYT   T     C+  D C+ G  C+            C C QG+        CE 
Sbjct: 1064 SCHKGYT--RTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCE- 1120

Query: 555  DIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCA 614
            DIDEC    + C +   C N  G + C C  GY  +G+    G+ CEDI+EC   +  C 
Sbjct: 1121 DIDECQHRHL-C-AHGQCRNTEGSFQCVCDQGYRASGL----GDHCEDINECLEDKSVCQ 1174

Query: 615  NDTICFNLDGGYDCRCPHG------KNC--TGDCIHDGKVKHNGQIWVLENDRCSVCSCQ 666
                C N  G YDC CP G      K C    +C H G     G+   L  +    C CQ
Sbjct: 1175 RGD-CINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGE--CLNTEGSFHCVCQ 1231

Query: 667  NGF-VMCRRMVCDCENPTVDLFCCPE---CDPRLSS-QCLHQNGETLYNSGDTWVQNCQQ 721
             GF +      C+  +  V+   C     CD    S +CL   G      G   V +  +
Sbjct: 1232 QGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCV-DVNE 1290

Query: 722  CRCLQGEVDCWPLPCPDVECEF 743
            C  L G   C    C +VE  F
Sbjct: 1291 CELLSGV--CGEAFCENVEGSF 1310



 Score =  130 bits (327), Expect = 5e-30
 Identities = 113/384 (29%), Positives = 155/384 (40%), Gaps = 92/384 (23%)

Query: 399  DFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCV 458
            D C   H       C NL  R  C C +G+R   E    C DIDEC + +H C +   C 
Sbjct: 883  DICGAGH-------CINLPVRYTCICYEGYR-FSEQQRKCVDIDECTQVQHLCSQG-RCE 933

Query: 459  NTPGSFMCICKTGYIRIDD-YSCTEHDECITNQHNCDENALCFNTVGGHNC-VCKPGYTG 516
            NT GSF+CIC  G++  ++  +C + DEC+     C E   C NTVG   C  C  GY  
Sbjct: 934  NTEGSFLCICPAGFMASEEGTNCIDVDECL-RPDVCGEGH-CVNTVGAFRCEYCDSGYRM 991

Query: 517  -------------NGTTCK-------------AFCKDG-------CRNGGACIAANVCA- 542
                         N +TC                C +G       C +   C+  NVCA 
Sbjct: 992  TQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCAN 1051

Query: 543  -------------CPQGFTGPSCE---TDIDECSDGFVQCDSRANCINLPGWYHCECRDG 586
                         C +G+T         DIDEC  G +  + +  C N  G + C C  G
Sbjct: 1052 GDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQ--CKNTEGSFRCTCGQG 1109

Query: 587  YHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTG-------- 638
            Y      S + + CEDIDEC   RH CA+   C N +G + C C  G   +G        
Sbjct: 1110 Y----QLSAAKDQCEDIDEC-QHRHLCAHGQ-CRNTEGSFQCVCDQGYRASGLGDHCEDI 1163

Query: 639  -DCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVC----DCENPTVDLFCCP--E 691
             +C+ D  V   G    +       C+C +GF +     C    +CE+P +   C P  E
Sbjct: 1164 NECLEDKSVCQRGD--CINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGL---CGPQGE 1218

Query: 692  C-DPRLSSQCLHQNGETLYNSGDT 714
            C +   S  C+ Q G ++   G T
Sbjct: 1219 CLNTEGSFHCVCQQGFSISADGRT 1242



 Score =  102 bits (253), Expect = 2e-21
 Identities = 109/410 (26%), Positives = 155/410 (37%), Gaps = 107/410 (26%)

Query: 284  FESWIDGCKNCTCLNGTIQCETLICPNPDCP-------LKSALAYVDGKCCKECKSI--C 334
            F  W     N  CL+     E  +C N DC              Y      K C+ I  C
Sbjct: 1030 FRGW-----NGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDEC 1084

Query: 335  QFQGRTYFEGE-RNTVYSSSGVC----VLYECKDQTMKLVESSGCPALDCPESHQITLSH 389
            Q QG     G+ +NT  S    C     L   KDQ   + E            H+   +H
Sbjct: 1085 Q-QGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQ----------HRHLCAH 1133

Query: 390  SCCK--------VC-KGY------DFCSERHNCMEN-SICR-----NLNDRAVCSCRDGF 428
              C+        VC +GY      D C + + C+E+ S+C+     N      C+C DGF
Sbjct: 1134 GQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGF 1193

Query: 429  RALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECI 487
            +   +DN  C+DI+EC E    C     C+NT GSF C+C+ G+ I  D  +C + DEC+
Sbjct: 1194 QL--DDNKTCQDINEC-EHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECV 1250

Query: 488  TNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGF 547
             N   CD +  C NT G   C+C  G+               ++G  C+  N C    G 
Sbjct: 1251 NNT-VCDSHGFCDNTAGSFRCLCYQGF------------QAPQDGQGCVDVNECELLSGV 1297

Query: 548  TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE------ 601
             G                    A C N+ G + C C D   +N  +SP    C       
Sbjct: 1298 CG-------------------EAFCENVEGSFLCVCAD---ENQEYSPMTGQCRSRTSTD 1335

Query: 602  ---DIDECGTGRHSC---AND-TICFNLDG----GYDCRCPHGKNCTGDC 640
               D+D+    +  C    ND ++C N+        +C C  G     +C
Sbjct: 1336 LDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNC 1385



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 103/361 (28%), Positives = 135/361 (37%), Gaps = 56/361 (15%)

Query: 440  DIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENAL 498
            +I+EC      C     C+N P  + CIC  GY        C + DEC   QH C +   
Sbjct: 874  EINECTVNPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGR- 931

Query: 499  CFNTVGGHNCVCKPGYTGN--GTTC--------KAFCKDG-CRNGGACIAANVCACPQGF 547
            C NT G   C+C  G+  +  GT C           C +G C N         C      
Sbjct: 932  CENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRM 991

Query: 548  TGPSCETDIDECSDGFVQCDSRANCINLPGWYHC-ECRDGYHD-NGMFSPSGESCEDIDE 605
            T      DIDEC +     D +  C+N PG Y C  C +G+   NG        C D+DE
Sbjct: 992  TQRGRCEDIDECLNPSTCPDEQ--CVNSPGSYQCVPCTEGFRGWNG-------QCLDVDE 1042

Query: 606  CGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS---- 661
            C    + CAN   C NL+G Y C C  G   T D  H   +    Q  +  N +C     
Sbjct: 1043 C-LEPNVCANGD-CSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEG 1100

Query: 662  --VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNC 719
               C+C  G+ +       CE+         EC  R    C H  G+     G       
Sbjct: 1101 SFRCTCGQGYQLSAAK-DQCED-------IDECQHR--HLCAH--GQCRNTEGSF----- 1143

Query: 720  QQCRCLQG-EVDCWPLPCPDV-EC--EFSILPENECCPRCVTDPCQA-DTIRNDITKTCL 774
             QC C QG         C D+ EC  + S+    +C     +  C   D  + D  KTC 
Sbjct: 1144 -QCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQ 1202

Query: 775  D 775
            D
Sbjct: 1203 D 1203



 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 104/424 (24%), Positives = 142/424 (33%), Gaps = 106/424 (25%)

Query: 289  DGCKNCTCLNG------TIQCETLICPNPDCPLKSALAYVDGKCCK---ECKSICQFQGR 339
            +G   CTC  G        QCE +     +C  +   A+  G+C       + +C    R
Sbjct: 1099 EGSFRCTCGQGYQLSAAKDQCEDI----DECQHRHLCAH--GQCRNTEGSFQCVCDQGYR 1152

Query: 340  TYFEGER----NTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVC 395
                G+     N       VC   +C       + ++G     CP+  Q+  +    K C
Sbjct: 1153 ASGLGDHCEDINECLEDKSVCQRGDC-------INTAGSYDCTCPDGFQLDDN----KTC 1201

Query: 396  KGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENT 455
            +  + C     C     C N      C C+ GF ++  D   CEDIDEC      C  + 
Sbjct: 1202 QDINECEHPGLCGPQGECLNTEGSFHCVCQQGF-SISADGRTCEDIDECVNNT-VCDSHG 1259

Query: 456  MCVNTPGSFMCICKTGYIRIDD-YSCTEHDECITNQHNCDENALCFNTVGGHNCVC---K 511
             C NT GSF C+C  G+    D   C + +EC      C E A C N  G   CVC    
Sbjct: 1260 FCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGE-AFCENVEGSFLCVCADEN 1318

Query: 512  PGYTGNGTTC------------------KAFCKDGCRNGGAC---IAANV----CACPQG 546
              Y+     C                  K  C     +   C   +A NV    C C  G
Sbjct: 1319 QEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSG 1378

Query: 547  FT-GPSCET-------------------------------------DIDECSDGFVQCDS 568
               G +CE                                      D DEC     +   
Sbjct: 1379 AGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICK 1438

Query: 569  RANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC 628
               C+N    Y C C+ G +    + P    C D+DEC     SC  D  C N +G Y+C
Sbjct: 1439 NGFCLNTRPGYECYCKQGTY----YDPVKLQCFDMDEC-QDPSSCI-DGQCVNTEGSYNC 1492

Query: 629  RCPH 632
             C H
Sbjct: 1493 FCTH 1496



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 73/287 (25%), Positives = 106/287 (36%), Gaps = 60/287 (20%)

Query: 550  PSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTG 609
            P+  T+I+EC+     C +  +CINLP  Y C C +GY     FS     C DIDEC   
Sbjct: 869  PTQVTEINECTVNPDICGA-GHCINLPVRYTCICYEGYR----FSEQQRKCVDIDECTQV 923

Query: 610  RHSCANDTICFNLDGGYDCRCP-------HGKNC--TGDCIHDGKVKHNGQIWVLENDRC 660
            +H C+    C N +G + C CP        G NC    +C+          +  +   RC
Sbjct: 924  QHLCSQGR-CENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRC 982

Query: 661  SVCSCQNGFVMCRRMVC----DCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWV 716
                C +G+ M +R  C    +C NP+     CP+       QC++  G           
Sbjct: 983  EY--CDSGYRMTQRGRCEDIDECLNPST----CPD------EQCVNSPGS---------- 1020

Query: 717  QNCQQC---------RCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRN 767
              C  C         +CL  +    P  C + +C  S L  +  C       C     R 
Sbjct: 1021 YQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDC--SNLEGSYMC------SCHKGYTRT 1072

Query: 768  DITKTC--LDEMNVVRFTGSSWIKHGTECTLCQCKNGHICCSVDPQC 812
               K C  +DE        +   K+      C C  G+   +   QC
Sbjct: 1073 PDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQC 1119



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 61/268 (22%), Positives = 84/268 (31%), Gaps = 52/268 (19%)

Query: 409  ENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCIC 468
            +N  C N      C C+ G          C D+DEC +    C +   CVNT GS+ C C
Sbjct: 1438 KNGFCLNTRPGYECYCKQG-TYYDPVKLQCFDMDECQDPSS-CIDG-QCVNTEGSYNCFC 1494

Query: 469  KTGYIR-IDDYSCTEHDECITNQHNCDE-NALCFNTVGGHNCVCKPGYTGNGTTCKAFCK 526
                +    +  C    E        D    LC+  +       +P      T  +  C 
Sbjct: 1495 THPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCL 1554

Query: 527  DGCRNGGACIA---------ANVCACP------------------------------QGF 547
             G   G  C           A +C  P                                F
Sbjct: 1555 YGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRF 1614

Query: 548  TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECG 607
                 E   +EC  G +       C+ +   Y C+C DGYH       +  +C D++EC 
Sbjct: 1615 LNSFEELQAEEC--GILNGCENGRCVRVQEGYTCDCFDGYH----LDTAKMTCVDVNECD 1668

Query: 608  --TGRHSCANDTICFNLDGGYDCRCPHG 633
                R S   +  C N DG Y C C  G
Sbjct: 1669 ELNNRMSLCKNAKCINTDGSYKCLCLPG 1696



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 29/92 (31%), Positives = 44/92 (47%), Gaps = 4/92 (4%)

Query: 406  NCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAE--GRHYCRENTMCVNTPGS 463
            N  EN  C  + +   C C DG+  L      C D++EC E   R    +N  C+NT GS
Sbjct: 1630 NGCENGRCVRVQEGYTCDCFDGYH-LDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGS 1688

Query: 464  FMCICKTGYIRIDDYS-CTEHDECITNQHNCD 494
            + C+C  GY+  D  + CT  +  +  + + D
Sbjct: 1689 YKCLCLPGYVPSDKPNYCTPLNTALNLEKDSD 1720



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 23/65 (35%), Positives = 34/65 (52%), Gaps = 3/65 (4%)

Query: 453  ENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDEC--ITNQHNCDENALCFNTVGGHNCV 509
            EN  CV     + C C  GY +     +C + +EC  + N+ +  +NA C NT G + C+
Sbjct: 1633 ENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCL 1692

Query: 510  CKPGY 514
            C PGY
Sbjct: 1693 CLPGY 1697



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 27/87 (31%), Positives = 44/87 (50%), Gaps = 9/87 (10%)

Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEH 483
           C  G++  R +N +C+DI+EC + +  C  N  C+NT GS+ C CK G+     +S    
Sbjct: 612 CLPGYK--RVNNTFCQDINEC-QLQGVC-PNGECLNTMGSYRCTCKIGFGPDPTFSSCVP 667

Query: 484 DECITNQHNCDENALCFNTV-GGHNCV 509
           D  + +    +E   C+  V  G  C+
Sbjct: 668 DPPVIS----EEKGPCYRLVSSGRQCM 690



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 19/54 (35%), Positives = 24/54 (44%)

Query: 501 NTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCET 554
           N  GG  C       G+    K  C   C+NGG C+   +C C  G  G +CET
Sbjct: 167 NVCGGRCCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGTKGKACET 220



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 32/109 (29%), Positives = 45/109 (41%), Gaps = 22/109 (20%)

Query: 465 MCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGT--TC- 521
           M  C  GY R+++  C + +EC   Q  C  N  C NT+G + C CK G+  + T  +C 
Sbjct: 609 MMECLPGYKRVNNTFCQDINECQL-QGVCP-NGECLNTMGSYRCTCKIGFGPDPTFSSCV 666

Query: 522 ---------KAFCKDGCRNGGAC-------IAANVCACPQGFT-GPSCE 553
                    K  C     +G  C       +   +C C  G   GP CE
Sbjct: 667 PDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCE 715



 Score = 36.6 bits (83), Expect = 0.096
 Identities = 14/36 (38%), Positives = 18/36 (50%)

Query: 525 CKDGCRNGGACIAANVCACPQGFTGPSCETDIDECS 560
           C   C NGG C + + C CP  FTG  C+  +   S
Sbjct: 403 CHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVHGAS 438



 Score = 35.0 bits (79), Expect = 0.28
 Identities = 22/69 (31%), Positives = 29/69 (42%), Gaps = 9/69 (13%)

Query: 527  DGCRNGGACIAAN---VCACPQGF---TGPSCETDIDECSD--GFVQCDSRANCINLPGW 578
            +GC NG  C+       C C  G+   T      D++EC +    +     A CIN  G 
Sbjct: 1630 NGCENG-RCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGS 1688

Query: 579  YHCECRDGY 587
            Y C C  GY
Sbjct: 1689 YKCLCLPGY 1697


>gi|46249412 latent transforming growth factor beta binding protein
           1 isoform LTBP-1S [Homo sapiens]
          Length = 1396

 Score =  130 bits (328), Expect = 4e-30
 Identities = 129/442 (29%), Positives = 170/442 (38%), Gaps = 62/442 (14%)

Query: 333 ICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCC 392
           IC ++G  + E +R  V       V + C     +  E S      CP     +   + C
Sbjct: 574 IC-YEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCI--CPAGFMASEEGTNC 630

Query: 393 ---KVCKGYDFCSERHNCMENSICRNLNDRAVCS-CRDGFRALREDNAYCEDIDECAEGR 448
                C   D C E H       C N      C  C  G+R  +     CEDIDEC    
Sbjct: 631 IDVDECLRPDVCGEGH-------CVNTVGAFRCEYCDSGYRMTQRGR--CEDIDECLNPS 681

Query: 449 HYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNC 508
               E   CVN+PGS+ C+  T   R  +  C + DEC+  + N   N  C N  G + C
Sbjct: 682 TCPDEQ--CVNSPGSYQCVPCTEGFRGWNGQCLDVDECL--EPNVCANGDCSNLEGSYMC 737

Query: 509 VCKPGYTGNGTTCKAFCK--DGCRNGGACIAANV--------CACPQGF----TGPSCET 554
            C  GYT   T     C+  D C+ G  C+            C C QG+        CE 
Sbjct: 738 SCHKGYT--RTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCE- 794

Query: 555 DIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCA 614
           DIDEC    + C +   C N  G + C C  GY  +G+    G+ CEDI+EC   +  C 
Sbjct: 795 DIDECQHRHL-C-AHGQCRNTEGSFQCVCDQGYRASGL----GDHCEDINECLEDKSVCQ 848

Query: 615 NDTICFNLDGGYDCRCPHG------KNC--TGDCIHDGKVKHNGQIWVLENDRCSVCSCQ 666
               C N  G YDC CP G      K C    +C H G     G+   L  +    C CQ
Sbjct: 849 RGD-CINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGE--CLNTEGSFHCVCQ 905

Query: 667 NGF-VMCRRMVCDCENPTVDLFCCPE---CDPRLSS-QCLHQNGETLYNSGDTWVQNCQQ 721
            GF +      C+  +  V+   C     CD    S +CL   G      G   V +  +
Sbjct: 906 QGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCV-DVNE 964

Query: 722 CRCLQGEVDCWPLPCPDVECEF 743
           C  L G   C    C +VE  F
Sbjct: 965 CELLSGV--CGEAFCENVEGSF 984



 Score =  130 bits (327), Expect = 5e-30
 Identities = 113/384 (29%), Positives = 155/384 (40%), Gaps = 92/384 (23%)

Query: 399 DFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCV 458
           D C   H       C NL  R  C C +G+R   E    C DIDEC + +H C +   C 
Sbjct: 557 DICGAGH-------CINLPVRYTCICYEGYR-FSEQQRKCVDIDECTQVQHLCSQG-RCE 607

Query: 459 NTPGSFMCICKTGYIRIDD-YSCTEHDECITNQHNCDENALCFNTVGGHNC-VCKPGYTG 516
           NT GSF+CIC  G++  ++  +C + DEC+     C E   C NTVG   C  C  GY  
Sbjct: 608 NTEGSFLCICPAGFMASEEGTNCIDVDECL-RPDVCGEGH-CVNTVGAFRCEYCDSGYRM 665

Query: 517 -------------NGTTCK-------------AFCKDG-------CRNGGACIAANVCA- 542
                        N +TC                C +G       C +   C+  NVCA 
Sbjct: 666 TQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCAN 725

Query: 543 -------------CPQGFTGPSCE---TDIDECSDGFVQCDSRANCINLPGWYHCECRDG 586
                        C +G+T         DIDEC  G +  + +  C N  G + C C  G
Sbjct: 726 GDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQ--CKNTEGSFRCTCGQG 783

Query: 587 YHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTG-------- 638
           Y      S + + CEDIDEC   RH CA+   C N +G + C C  G   +G        
Sbjct: 784 Y----QLSAAKDQCEDIDEC-QHRHLCAHGQ-CRNTEGSFQCVCDQGYRASGLGDHCEDI 837

Query: 639 -DCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVC----DCENPTVDLFCCP--E 691
            +C+ D  V   G    +       C+C +GF +     C    +CE+P +   C P  E
Sbjct: 838 NECLEDKSVCQRGD--CINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGL---CGPQGE 892

Query: 692 C-DPRLSSQCLHQNGETLYNSGDT 714
           C +   S  C+ Q G ++   G T
Sbjct: 893 CLNTEGSFHCVCQQGFSISADGRT 916



 Score =  102 bits (253), Expect = 2e-21
 Identities = 109/410 (26%), Positives = 155/410 (37%), Gaps = 107/410 (26%)

Query: 284  FESWIDGCKNCTCLNGTIQCETLICPNPDCP-------LKSALAYVDGKCCKECKSI--C 334
            F  W     N  CL+     E  +C N DC              Y      K C+ I  C
Sbjct: 704  FRGW-----NGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDEC 758

Query: 335  QFQGRTYFEGE-RNTVYSSSGVC----VLYECKDQTMKLVESSGCPALDCPESHQITLSH 389
            Q QG     G+ +NT  S    C     L   KDQ   + E            H+   +H
Sbjct: 759  Q-QGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQ----------HRHLCAH 807

Query: 390  SCCK--------VC-KGY------DFCSERHNCMEN-SICR-----NLNDRAVCSCRDGF 428
              C+        VC +GY      D C + + C+E+ S+C+     N      C+C DGF
Sbjct: 808  GQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGF 867

Query: 429  RALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECI 487
            +   +DN  C+DI+EC E    C     C+NT GSF C+C+ G+ I  D  +C + DEC+
Sbjct: 868  QL--DDNKTCQDINEC-EHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECV 924

Query: 488  TNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGF 547
             N   CD +  C NT G   C+C  G+               ++G  C+  N C    G 
Sbjct: 925  NNT-VCDSHGFCDNTAGSFRCLCYQGF------------QAPQDGQGCVDVNECELLSGV 971

Query: 548  TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE------ 601
             G                    A C N+ G + C C D   +N  +SP    C       
Sbjct: 972  CG-------------------EAFCENVEGSFLCVCAD---ENQEYSPMTGQCRSRTSTD 1009

Query: 602  ---DIDECGTGRHSC---AND-TICFNLDG----GYDCRCPHGKNCTGDC 640
               D+D+    +  C    ND ++C N+        +C C  G     +C
Sbjct: 1010 LDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNC 1059



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 103/361 (28%), Positives = 135/361 (37%), Gaps = 56/361 (15%)

Query: 440 DIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENAL 498
           +I+EC      C     C+N P  + CIC  GY        C + DEC   QH C +   
Sbjct: 548 EINECTVNPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGR- 605

Query: 499 CFNTVGGHNCVCKPGYTGN--GTTC--------KAFCKDG-CRNGGACIAANVCACPQGF 547
           C NT G   C+C  G+  +  GT C           C +G C N         C      
Sbjct: 606 CENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRM 665

Query: 548 TGPSCETDIDECSDGFVQCDSRANCINLPGWYHC-ECRDGYHD-NGMFSPSGESCEDIDE 605
           T      DIDEC +     D +  C+N PG Y C  C +G+   NG        C D+DE
Sbjct: 666 TQRGRCEDIDECLNPSTCPDEQ--CVNSPGSYQCVPCTEGFRGWNG-------QCLDVDE 716

Query: 606 CGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS---- 661
           C    + CAN   C NL+G Y C C  G   T D  H   +    Q  +  N +C     
Sbjct: 717 C-LEPNVCANGD-CSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEG 774

Query: 662 --VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNC 719
              C+C  G+ +       CE+         EC  R    C H  G+     G       
Sbjct: 775 SFRCTCGQGYQLSAAK-DQCED-------IDECQHR--HLCAH--GQCRNTEGSF----- 817

Query: 720 QQCRCLQG-EVDCWPLPCPDV-EC--EFSILPENECCPRCVTDPCQA-DTIRNDITKTCL 774
            QC C QG         C D+ EC  + S+    +C     +  C   D  + D  KTC 
Sbjct: 818 -QCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQ 876

Query: 775 D 775
           D
Sbjct: 877 D 877



 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 104/424 (24%), Positives = 142/424 (33%), Gaps = 106/424 (25%)

Query: 289  DGCKNCTCLNG------TIQCETLICPNPDCPLKSALAYVDGKCCK---ECKSICQFQGR 339
            +G   CTC  G        QCE +     +C  +   A+  G+C       + +C    R
Sbjct: 773  EGSFRCTCGQGYQLSAAKDQCEDI----DECQHRHLCAH--GQCRNTEGSFQCVCDQGYR 826

Query: 340  TYFEGER----NTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVC 395
                G+     N       VC   +C       + ++G     CP+  Q+  +    K C
Sbjct: 827  ASGLGDHCEDINECLEDKSVCQRGDC-------INTAGSYDCTCPDGFQLDDN----KTC 875

Query: 396  KGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENT 455
            +  + C     C     C N      C C+ GF ++  D   CEDIDEC      C  + 
Sbjct: 876  QDINECEHPGLCGPQGECLNTEGSFHCVCQQGF-SISADGRTCEDIDECVNNT-VCDSHG 933

Query: 456  MCVNTPGSFMCICKTGYIRIDD-YSCTEHDECITNQHNCDENALCFNTVGGHNCVC---K 511
             C NT GSF C+C  G+    D   C + +EC      C E A C N  G   CVC    
Sbjct: 934  FCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGE-AFCENVEGSFLCVCADEN 992

Query: 512  PGYTGNGTTC------------------KAFCKDGCRNGGAC---IAANV----CACPQG 546
              Y+     C                  K  C     +   C   +A NV    C C  G
Sbjct: 993  QEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSG 1052

Query: 547  FT-GPSCET-------------------------------------DIDECSDGFVQCDS 568
               G +CE                                      D DEC     +   
Sbjct: 1053 AGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICK 1112

Query: 569  RANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC 628
               C+N    Y C C+ G +    + P    C D+DEC     SC  D  C N +G Y+C
Sbjct: 1113 NGFCLNTRPGYECYCKQGTY----YDPVKLQCFDMDEC-QDPSSCI-DGQCVNTEGSYNC 1166

Query: 629  RCPH 632
             C H
Sbjct: 1167 FCTH 1170



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 73/287 (25%), Positives = 106/287 (36%), Gaps = 60/287 (20%)

Query: 550 PSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTG 609
           P+  T+I+EC+     C +  +CINLP  Y C C +GY     FS     C DIDEC   
Sbjct: 543 PTQVTEINECTVNPDICGA-GHCINLPVRYTCICYEGYR----FSEQQRKCVDIDECTQV 597

Query: 610 RHSCANDTICFNLDGGYDCRCP-------HGKNC--TGDCIHDGKVKHNGQIWVLENDRC 660
           +H C+    C N +G + C CP        G NC    +C+          +  +   RC
Sbjct: 598 QHLCSQGR-CENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRC 656

Query: 661 SVCSCQNGFVMCRRMVC----DCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWV 716
               C +G+ M +R  C    +C NP+     CP+       QC++  G           
Sbjct: 657 EY--CDSGYRMTQRGRCEDIDECLNPST----CPD------EQCVNSPGS---------- 694

Query: 717 QNCQQC---------RCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRN 767
             C  C         +CL  +    P  C + +C  S L  +  C       C     R 
Sbjct: 695 YQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDC--SNLEGSYMC------SCHKGYTRT 746

Query: 768 DITKTC--LDEMNVVRFTGSSWIKHGTECTLCQCKNGHICCSVDPQC 812
              K C  +DE        +   K+      C C  G+   +   QC
Sbjct: 747 PDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQC 793



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 61/268 (22%), Positives = 84/268 (31%), Gaps = 52/268 (19%)

Query: 409  ENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCIC 468
            +N  C N      C C+ G          C D+DEC +    C +   CVNT GS+ C C
Sbjct: 1112 KNGFCLNTRPGYECYCKQG-TYYDPVKLQCFDMDECQDPSS-CIDG-QCVNTEGSYNCFC 1168

Query: 469  KTGYIR-IDDYSCTEHDECITNQHNCDE-NALCFNTVGGHNCVCKPGYTGNGTTCKAFCK 526
                +    +  C    E        D    LC+  +       +P      T  +  C 
Sbjct: 1169 THPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCL 1228

Query: 527  DGCRNGGACIA---------ANVCACP------------------------------QGF 547
             G   G  C           A +C  P                                F
Sbjct: 1229 YGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRF 1288

Query: 548  TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECG 607
                 E   +EC  G +       C+ +   Y C+C DGYH       +  +C D++EC 
Sbjct: 1289 LNSFEELQAEEC--GILNGCENGRCVRVQEGYTCDCFDGYH----LDTAKMTCVDVNECD 1342

Query: 608  --TGRHSCANDTICFNLDGGYDCRCPHG 633
                R S   +  C N DG Y C C  G
Sbjct: 1343 ELNNRMSLCKNAKCINTDGSYKCLCLPG 1370



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 29/92 (31%), Positives = 44/92 (47%), Gaps = 4/92 (4%)

Query: 406  NCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAE--GRHYCRENTMCVNTPGS 463
            N  EN  C  + +   C C DG+  L      C D++EC E   R    +N  C+NT GS
Sbjct: 1304 NGCENGRCVRVQEGYTCDCFDGYH-LDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGS 1362

Query: 464  FMCICKTGYIRIDDYS-CTEHDECITNQHNCD 494
            + C+C  GY+  D  + CT  +  +  + + D
Sbjct: 1363 YKCLCLPGYVPSDKPNYCTPLNTALNLEKDSD 1394



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 23/65 (35%), Positives = 34/65 (52%), Gaps = 3/65 (4%)

Query: 453  ENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDEC--ITNQHNCDENALCFNTVGGHNCV 509
            EN  CV     + C C  GY +     +C + +EC  + N+ +  +NA C NT G + C+
Sbjct: 1307 ENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCL 1366

Query: 510  CKPGY 514
            C PGY
Sbjct: 1367 CLPGY 1371



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 27/87 (31%), Positives = 44/87 (50%), Gaps = 9/87 (10%)

Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEH 483
           C  G++  R +N +C+DI+EC + +  C  N  C+NT GS+ C CK G+     +S    
Sbjct: 286 CLPGYK--RVNNTFCQDINEC-QLQGVC-PNGECLNTMGSYRCTCKIGFGPDPTFSSCVP 341

Query: 484 DECITNQHNCDENALCFNTV-GGHNCV 509
           D  + +    +E   C+  V  G  C+
Sbjct: 342 DPPVIS----EEKGPCYRLVSSGRQCM 364



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 32/109 (29%), Positives = 45/109 (41%), Gaps = 22/109 (20%)

Query: 465 MCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGT--TC- 521
           M  C  GY R+++  C + +EC   Q  C  N  C NT+G + C CK G+  + T  +C 
Sbjct: 283 MMECLPGYKRVNNTFCQDINECQL-QGVCP-NGECLNTMGSYRCTCKIGFGPDPTFSSCV 340

Query: 522 ---------KAFCKDGCRNGGAC-------IAANVCACPQGFT-GPSCE 553
                    K  C     +G  C       +   +C C  G   GP CE
Sbjct: 341 PDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCE 389



 Score = 36.6 bits (83), Expect = 0.096
 Identities = 14/36 (38%), Positives = 18/36 (50%)

Query: 525 CKDGCRNGGACIAANVCACPQGFTGPSCETDIDECS 560
           C   C NGG C + + C CP  FTG  C+  +   S
Sbjct: 77  CHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVHGAS 112



 Score = 35.0 bits (79), Expect = 0.28
 Identities = 22/69 (31%), Positives = 29/69 (42%), Gaps = 9/69 (13%)

Query: 527  DGCRNGGACIAAN---VCACPQGF---TGPSCETDIDECSD--GFVQCDSRANCINLPGW 578
            +GC NG  C+       C C  G+   T      D++EC +    +     A CIN  G 
Sbjct: 1304 NGCENG-RCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGS 1362

Query: 579  YHCECRDGY 587
            Y C C  GY
Sbjct: 1363 YKCLCLPGY 1371


>gi|110347437 latent transforming growth factor beta binding protein
           4 isoform c [Homo sapiens]
          Length = 1557

 Score =  129 bits (325), Expect = 8e-30
 Identities = 107/394 (27%), Positives = 136/394 (34%), Gaps = 90/394 (22%)

Query: 379 CPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYC 438
           CP  +Q    H     C+  D C++         C+NL     C C  GFR     +A  
Sbjct: 589 CPAGYQAA-PHGAS--CQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRG----SACE 641

Query: 439 EDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENA 497
           ED+DECA+    C     C NT GSF C C  G+  R     C + DEC  +   C    
Sbjct: 642 EDVDECAQEPPPCGPGR-CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGR 700

Query: 498 LCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCE---- 553
            C NT G   CVC  G+  N    +    D C N  AC        P  F   +C     
Sbjct: 701 -CENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHH 759

Query: 554 ------TDIDECSDGFVQCDSRANCINLPGWYHCECRDGY-------------------- 587
                 TD+DECS G   C    +C N  G + C C  GY                    
Sbjct: 760 LHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGD 819

Query: 588 ---------HDNGMFS----------PSGESCEDIDECGTGRHSCANDTICFNLDGGYDC 628
                    + +G F+          P G SC D+DEC           IC N DG ++C
Sbjct: 820 FCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS--EEDLCQSGICTNTDGSFEC 877

Query: 629 RCPHGKNCTGD---CIHDGKVKHNGQIWVLENDRCS--------VCSCQNGFVMCRRMVC 677
            CP G     D   C+   + +  G   +  + RC         V  C  G+       C
Sbjct: 878 ICPPGHRAGPDLASCLDVDECRERGPA-LCGSQRCENSPGSYRCVRDCDPGYHAGPEGTC 936

Query: 678 D-----------------CENPTVDLFCCPECDP 694
           D                 CEN      C P CDP
Sbjct: 937 DDVDECQEYGPEICGAQRCENTPGSYRCTPACDP 970



 Score =  127 bits (320), Expect = 3e-29
 Identities = 86/283 (30%), Positives = 115/283 (40%), Gaps = 34/283 (12%)

Query: 379  CPESHQITLSHSCCKVCKGYDFCSE-RHNCMENSICRNLNDRAVCSCRDGFRALREDNAY 437
            CP  H +         C   D CS     C  +  C N      CSC  G+RA       
Sbjct: 754  CPSGHHLHRGR-----CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGP 808

Query: 438  CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRID-DYSCTEHDECITNQHNCDEN 496
            C D++EC EG  +C  +  C+NT GSF C C  GY       SC + DEC  ++ +  ++
Sbjct: 809  CADVNECLEG-DFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDEC--SEEDLCQS 865

Query: 497  ALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAAN------------VCACP 544
             +C NT G   C+C PG+            D CR  G  +  +            V  C 
Sbjct: 866  GICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCD 925

Query: 545  QGF-TGP--SCETDIDECSDGFVQCDSRANCINLPGWYHCE--CRDGYHDNGMFSPSGES 599
             G+  GP  +C+ D+DEC +   +      C N PG Y C   C  GY         G  
Sbjct: 926  PGYHAGPEGTCD-DVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPT-----PGGG 979

Query: 600  CEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIH 642
            C+D+DEC   R  C    +C NL G + C C  G     D  H
Sbjct: 980  CQDVDEC-RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRH 1021



 Score =  124 bits (311), Expect = 4e-28
 Identities = 107/353 (30%), Positives = 136/353 (38%), Gaps = 51/353 (14%)

Query: 422 CSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYS-C 480
           C+C  GFR L      C D+DEC      C     C N+PGSF C+C  G+      + C
Sbjct: 503 CACDSGFR-LSPQGTRCIDVDECRRVPPPCAPGR-CENSPGSFRCVCGPGFRAGPRAAEC 560

Query: 481 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTG--NGTTCKAFCK----DGCRNGGA 534
            + DEC      CD    C NT G   CVC  GY    +G +C+   +     G    GA
Sbjct: 561 LDVDECHRVPPPCDLGR-CENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA 619

Query: 535 CI---AANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNG 591
           C     +  C CP GF G +CE D+DEC+     C     C N  G +HC C  G+   G
Sbjct: 620 CKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPC-GPGRCDNTAGSFHCACPAGFRSRG 678

Query: 592 MFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG--KNCTGDCIHDGKVKHN 649
                G  C+D+DEC      C     C N +G + C CP G   N  G    D     N
Sbjct: 679 ----PGAPCQDVDECARSPPPCTYGR-CENTEGSFQCVCPMGFQPNTAGSECEDVDECEN 733

Query: 650 -----GQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQN 704
                GQ  V         +C +G  + R    D +  +      P C P     C +  
Sbjct: 734 HLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSG---APPCGPH--GHCTNTE 788

Query: 705 GETLYNSGDTWVQNCQQCRCLQG--EVDCWPLPCPDV-EC---EFSILPENEC 751
           G               +C C  G       P PC DV EC   +F   P  EC
Sbjct: 789 GSF-------------RCSCAPGYRAPSGRPGPCADVNECLEGDF-CFPHGEC 827



 Score =  117 bits (292), Expect = 6e-26
 Identities = 88/270 (32%), Positives = 119/270 (44%), Gaps = 35/270 (12%)

Query: 395  CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
            C   + C E   C  +  C N +    C+C  G+R      A C D+DEC+E    C+  
Sbjct: 809  CADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRP-GPRGASCLDVDECSE-EDLCQSG 866

Query: 455  TMCVNTPGSFMCICKTGYIRIDDY-SCTEHDECITNQHNCDENALCFNTVGGHNCV--CK 511
             +C NT GSF CIC  G+    D  SC + DEC         +  C N+ G + CV  C 
Sbjct: 867  -ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCD 925

Query: 512  PGY-TGNGTTCKAFCKDGCRNGGACIA-ANVC-----------ACPQGFT---GPSCETD 555
            PGY  G   TC     D C+  G  I  A  C           AC  G+    G  C+ D
Sbjct: 926  PGYHAGPEGTCDDV--DECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQ-D 982

Query: 556  IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCAN 615
            +DEC +    C + A C NLPG + C C  GY      +  G  C D++EC T +  C  
Sbjct: 983  VDECRNRSF-CGAHAVCQNLPGSFQCLCDQGYEG----ARDGRHCVDVNECETLQGVC-G 1036

Query: 616  DTICFNLDGGYDCRCPHGKN----CTGDCI 641
              +C N++G + C CP+        TG C+
Sbjct: 1037 AALCENVEGSFLCVCPNSPEEFDPMTGRCV 1066



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 66/207 (31%), Positives = 86/207 (41%), Gaps = 34/207 (16%)

Query: 360  ECKDQTMKLVESSGCPALD------CPESHQITLSHSCCKVCKGYDFCSERHNCMENSI- 412
            EC ++   L +S  C   D      CP  H+     + C      D C ER   +  S  
Sbjct: 856  ECSEED--LCQSGICTNTDGSFECICPPGHRAGPDLASCL---DVDECRERGPALCGSQR 910

Query: 413  CRNL--NDRAVCSCRDGFRALREDNAYCEDIDECAE-GRHYCRENTMCVNTPGSFMCI-- 467
            C N   + R V  C  G+ A  E    C+D+DEC E G   C     C NTPGS+ C   
Sbjct: 911  CENSPGSYRCVRDCDPGYHAGPEGT--CDDVDECQEYGPEICGAQR-CENTPGSYRCTPA 967

Query: 468  CKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKD 527
            C  GY       C + DEC  N+  C  +A+C N  G   C+C  GY            +
Sbjct: 968  CDPGYQPTPGGGCQDVDEC-RNRSFCGAHAVCQNLPGSFQCLCDQGY------------E 1014

Query: 528  GCRNGGACIAANVCACPQGFTGPS-CE 553
            G R+G  C+  N C   QG  G + CE
Sbjct: 1015 GARDGRHCVDVNECETLQGVCGAALCE 1041



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 90/384 (23%), Positives = 127/384 (33%), Gaps = 96/384 (25%)

Query: 395  CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
            C+  D C  R  C  +++C+NL     C C  G+   R D  +C D++EC   +  C   
Sbjct: 980  CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGAR-DGRHCVDVNECETLQGVCGA- 1037

Query: 455  TMCVNTPGSFMCICKTGYIRIDDYS--CTEHDECITNQHNCDENALCFNTVGGHN----- 507
             +C N  GSF+C+C       D  +  C                A     +         
Sbjct: 1038 ALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPL 1097

Query: 508  ----CVCKPGYTGNGTTCKAF---CKDGCRNGGACIAANV----CACPQGFT-GPSCETD 555
                   + G  G+G     F     D C N    +A NV    C C  G   G  C   
Sbjct: 1098 PRRPSTPRQGPVGSGRRECYFDTAAPDACDN---ILARNVTWQECCCTVGEGWGSGCR-- 1152

Query: 556  IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC--EDIDECGTGRHSC 613
            I +C  G    + ++ C               H  G  +PSG+     D+DEC   R   
Sbjct: 1153 IQQCP-GTETAEYQSLCP--------------HGRGYLAPSGDLSLRRDVDECQLFRDQV 1197

Query: 614  ANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS--VCSCQNGFVM 671
                +C N   GY C C            +G   H  ++  ++ND C+    +C+ G   
Sbjct: 1198 CKSGVCVNTAPGYSCYC-----------SNGYYYHTQRLECIDNDECADEEPACEGG--R 1244

Query: 672  CRRMV----CDCENPTV-----------------------------DLFCCPECDPRLSS 698
            C   V    C CE P V                             DL C     PRL  
Sbjct: 1245 CVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVC---SHPRLDR 1301

Query: 699  QCLHQNGETLYNSGDTWVQNCQQC 722
            Q  +     LY  G+ W  +C  C
Sbjct: 1302 QATYTECCCLY--GEAWGMDCALC 1323



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 38/139 (27%), Positives = 60/139 (43%), Gaps = 5/139 (3%)

Query: 382  SHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDI 441
            +  +T    CC V +G+        C           +++C    G+ A   D +   D+
Sbjct: 1131 ARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEY---QSLCPHGRGYLAPSGDLSLRRDV 1187

Query: 442  DECAEGRHYCRENTMCVNTPGSFMCICKTG-YIRIDDYSCTEHDECITNQHNCDENALCF 500
            DEC   R    ++ +CVNT   + C C  G Y       C ++DEC   +  C E   C 
Sbjct: 1188 DECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPAC-EGGRCV 1246

Query: 501  NTVGGHNCVCKPGYTGNGT 519
            NTVG ++C C+P    +G+
Sbjct: 1247 NTVGSYHCTCEPPLVLDGS 1265



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 49/166 (29%), Positives = 68/166 (40%), Gaps = 26/166 (15%)

Query: 360  ECKDQTMKLVESSGCP--------ALDCPESHQITLSHSCCKV--CKGY--DFCSERHNC 407
            EC+++   L  S  C           DC   +      +C  V  C+ Y  + C  +   
Sbjct: 897  ECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQR-- 954

Query: 408  MENSICRNLNDRAVCS--CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFM 465
                 C N      C+  C  G++        C+D+DEC   R +C  + +C N PGSF 
Sbjct: 955  -----CENTPGSYRCTPACDPGYQPT--PGGGCQDVDEC-RNRSFCGAHAVCQNLPGSFQ 1006

Query: 466  CICKTGYIRI-DDYSCTEHDECITNQHNCDENALCFNTVGGHNCVC 510
            C+C  GY    D   C + +EC T Q  C   ALC N  G   CVC
Sbjct: 1007 CLCDQGYEGARDGRHCVDVNECETLQGVCGA-ALCENVEGSFLCVC 1051



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 26/65 (40%), Positives = 33/65 (50%), Gaps = 3/65 (4%)

Query: 410  NSICRNLNDRAVCSCRDGFRALREDNAYCEDIDEC--AEGRHYCRENTMCVNTPGSFMCI 467
            N  C  + +   C C DG+R L      C DI+EC  AE       N  C+NT GSF CI
Sbjct: 1478 NGRCVRVPEGFTCRCFDGYR-LDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCI 1536

Query: 468  CKTGY 472
            C+ G+
Sbjct: 1537 CRPGF 1541



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 28/81 (34%), Positives = 37/81 (45%), Gaps = 13/81 (16%)

Query: 438  CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRID--DYSCTEHDECITNQHNCD- 494
            C  +D C  GR        CV  P  F C C  GY R+D    +C + +EC   +     
Sbjct: 1470 CGILDGCTNGR--------CVRVPEGFTCRCFDGY-RLDMTRMACVDINECDEAEAASPL 1520

Query: 495  -ENALCFNTVGGHNCVCKPGY 514
              NA C NT G   C+C+PG+
Sbjct: 1521 CVNARCLNTDGSFRCICRPGF 1541



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 32/117 (27%), Positives = 48/117 (41%), Gaps = 13/117 (11%)

Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCS---CRDGFRALREDNAYCEDIDECAEGRHYC 451
           C+G       H+C   S     ++R       C  GF  +   N  CED+DECA G   C
Sbjct: 245 CRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERV---NGSCEDVDECATGGR-C 300

Query: 452 RENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNC 508
           +    C NT G + C+C  G++ +D    +    CI+     +    CF  +    C
Sbjct: 301 QHGE-CANTRGGYTCVCPDGFL-LD----SSRSSCISQHVISEAKGPCFRVLRDGGC 351



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 26/87 (29%), Positives = 38/87 (43%), Gaps = 10/87 (11%)

Query: 550  PSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTG 609
            P  E + +EC  G +   +   C+ +P  + C C DGY        +  +C DI+EC   
Sbjct: 1461 PYEELEAEEC--GILDGCTNGRCVRVPEGFTCRCFDGYR----LDMTRMACVDINECDEA 1514

Query: 610  RHS---CANDTICFNLDGGYDCRCPHG 633
              +   C N   C N DG + C C  G
Sbjct: 1515 EAASPLCVN-ARCLNTDGSFRCICRPG 1540



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 38/132 (28%), Positives = 57/132 (43%), Gaps = 27/132 (20%)

Query: 468 CKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGY--TGNGTTC---- 521
           C TG+ R++  SC + DEC T    C ++  C NT GG+ CVC  G+    + ++C    
Sbjct: 277 CPTGFERVNG-SCEDVDECATGGR-C-QHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 333

Query: 522 -----KAFCKDGCRNGGAC------IAANVCACPQ--GFTGPSCETDIDECSDGFVQCDS 568
                K  C    R+GG        I   +C C +     G  C+      S+GF     
Sbjct: 334 VISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGF----- 388

Query: 569 RANCINLPGWYH 580
           R  C   PG+++
Sbjct: 389 REICPAGPGYHY 400



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 18/35 (51%), Positives = 20/35 (57%), Gaps = 2/35 (5%)

Query: 599 SCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG 633
           SCED+DEC TG      +  C N  GGY C CP G
Sbjct: 287 SCEDVDECATGGRCQHGE--CANTRGGYTCVCPDG 319



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 34/116 (29%), Positives = 44/116 (37%), Gaps = 22/116 (18%)

Query: 499 CFNTVGGHNCVCK-PGYTGNGTTCKA-----------FCKDGCRNGGACIAANVCACPQG 546
           CF  + G  C    PG       C+             C +   N    ++A    CP G
Sbjct: 222 CFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSER-VSAPDGPCPTG 280

Query: 547 F--TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
           F     SCE D+DEC+ G  +C     C N  G Y C C DG+    +   S  SC
Sbjct: 281 FERVNGSCE-DVDECATGG-RCQ-HGECANTRGGYTCVCPDGF----LLDSSRSSC 329



 Score = 35.4 bits (80), Expect = 0.21
 Identities = 16/42 (38%), Positives = 20/42 (47%), Gaps = 1/42 (2%)

Query: 513 GYTGNGTTCKAF-CKDGCRNGGACIAANVCACPQGFTGPSCE 553
           G    G   +AF C   C NGG C+  + C CP  F G  C+
Sbjct: 73  GAAPGGPGFRAFLCPLICHNGGVCVKPDRCLCPPDFAGKFCQ 114



 Score = 35.0 bits (79), Expect = 0.28
 Identities = 23/70 (32%), Positives = 31/70 (44%), Gaps = 11/70 (15%)

Query: 527  DGCRNGGACIAAN---VCACPQGF----TGPSCETDIDECSDGFVQCDS--RANCINLPG 577
            DGC NG  C+       C C  G+    T  +C  DI+EC +          A C+N  G
Sbjct: 1474 DGCTNG-RCVRVPEGFTCRCFDGYRLDMTRMAC-VDINECDEAEAASPLCVNARCLNTDG 1531

Query: 578  WYHCECRDGY 587
             + C CR G+
Sbjct: 1532 SFRCICRPGF 1541


>gi|110347412 latent transforming growth factor beta binding protein 4
            isoform b [Homo sapiens]
          Length = 1587

 Score =  129 bits (325), Expect = 8e-30
 Identities = 107/394 (27%), Positives = 136/394 (34%), Gaps = 90/394 (22%)

Query: 379  CPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYC 438
            CP  +Q    H     C+  D C++         C+NL     C C  GFR     +A  
Sbjct: 619  CPAGYQAA-PHGAS--CQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRG----SACE 671

Query: 439  EDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENA 497
            ED+DECA+    C     C NT GSF C C  G+  R     C + DEC  +   C    
Sbjct: 672  EDVDECAQEPPPCGPGR-CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGR 730

Query: 498  LCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCE---- 553
             C NT G   CVC  G+  N    +    D C N  AC        P  F   +C     
Sbjct: 731  -CENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHH 789

Query: 554  ------TDIDECSDGFVQCDSRANCINLPGWYHCECRDGY-------------------- 587
                  TD+DECS G   C    +C N  G + C C  GY                    
Sbjct: 790  LHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGD 849

Query: 588  ---------HDNGMFS----------PSGESCEDIDECGTGRHSCANDTICFNLDGGYDC 628
                     + +G F+          P G SC D+DEC           IC N DG ++C
Sbjct: 850  FCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS--EEDLCQSGICTNTDGSFEC 907

Query: 629  RCPHGKNCTGD---CIHDGKVKHNGQIWVLENDRCS--------VCSCQNGFVMCRRMVC 677
             CP G     D   C+   + +  G   +  + RC         V  C  G+       C
Sbjct: 908  ICPPGHRAGPDLASCLDVDECRERGPA-LCGSQRCENSPGSYRCVRDCDPGYHAGPEGTC 966

Query: 678  D-----------------CENPTVDLFCCPECDP 694
            D                 CEN      C P CDP
Sbjct: 967  DDVDECQEYGPEICGAQRCENTPGSYRCTPACDP 1000



 Score =  127 bits (320), Expect = 3e-29
 Identities = 86/283 (30%), Positives = 115/283 (40%), Gaps = 34/283 (12%)

Query: 379  CPESHQITLSHSCCKVCKGYDFCSE-RHNCMENSICRNLNDRAVCSCRDGFRALREDNAY 437
            CP  H +         C   D CS     C  +  C N      CSC  G+RA       
Sbjct: 784  CPSGHHLHRGR-----CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGP 838

Query: 438  CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRID-DYSCTEHDECITNQHNCDEN 496
            C D++EC EG  +C  +  C+NT GSF C C  GY       SC + DEC  ++ +  ++
Sbjct: 839  CADVNECLEG-DFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDEC--SEEDLCQS 895

Query: 497  ALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAAN------------VCACP 544
             +C NT G   C+C PG+            D CR  G  +  +            V  C 
Sbjct: 896  GICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCD 955

Query: 545  QGF-TGP--SCETDIDECSDGFVQCDSRANCINLPGWYHCE--CRDGYHDNGMFSPSGES 599
             G+  GP  +C+ D+DEC +   +      C N PG Y C   C  GY         G  
Sbjct: 956  PGYHAGPEGTCD-DVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPT-----PGGG 1009

Query: 600  CEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIH 642
            C+D+DEC   R  C    +C NL G + C C  G     D  H
Sbjct: 1010 CQDVDEC-RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRH 1051



 Score =  124 bits (311), Expect = 4e-28
 Identities = 107/353 (30%), Positives = 136/353 (38%), Gaps = 51/353 (14%)

Query: 422 CSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYS-C 480
           C+C  GFR L      C D+DEC      C     C N+PGSF C+C  G+      + C
Sbjct: 533 CACDSGFR-LSPQGTRCIDVDECRRVPPPCAPGR-CENSPGSFRCVCGPGFRAGPRAAEC 590

Query: 481 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTG--NGTTCKAFCK----DGCRNGGA 534
            + DEC      CD    C NT G   CVC  GY    +G +C+   +     G    GA
Sbjct: 591 LDVDECHRVPPPCDLGR-CENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA 649

Query: 535 CI---AANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNG 591
           C     +  C CP GF G +CE D+DEC+     C     C N  G +HC C  G+   G
Sbjct: 650 CKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPC-GPGRCDNTAGSFHCACPAGFRSRG 708

Query: 592 MFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG--KNCTGDCIHDGKVKHN 649
                G  C+D+DEC      C     C N +G + C CP G   N  G    D     N
Sbjct: 709 ----PGAPCQDVDECARSPPPCTYGR-CENTEGSFQCVCPMGFQPNTAGSECEDVDECEN 763

Query: 650 -----GQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQN 704
                GQ  V         +C +G  + R    D +  +      P C P     C +  
Sbjct: 764 HLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSG---APPCGPH--GHCTNTE 818

Query: 705 GETLYNSGDTWVQNCQQCRCLQG--EVDCWPLPCPDV-EC---EFSILPENEC 751
           G               +C C  G       P PC DV EC   +F   P  EC
Sbjct: 819 GSF-------------RCSCAPGYRAPSGRPGPCADVNECLEGDF-CFPHGEC 857



 Score =  117 bits (292), Expect = 6e-26
 Identities = 88/270 (32%), Positives = 119/270 (44%), Gaps = 35/270 (12%)

Query: 395  CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
            C   + C E   C  +  C N +    C+C  G+R      A C D+DEC+E    C+  
Sbjct: 839  CADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRP-GPRGASCLDVDECSE-EDLCQSG 896

Query: 455  TMCVNTPGSFMCICKTGYIRIDDY-SCTEHDECITNQHNCDENALCFNTVGGHNCV--CK 511
             +C NT GSF CIC  G+    D  SC + DEC         +  C N+ G + CV  C 
Sbjct: 897  -ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCD 955

Query: 512  PGY-TGNGTTCKAFCKDGCRNGGACIA-ANVC-----------ACPQGFT---GPSCETD 555
            PGY  G   TC     D C+  G  I  A  C           AC  G+    G  C+ D
Sbjct: 956  PGYHAGPEGTCDDV--DECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQ-D 1012

Query: 556  IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCAN 615
            +DEC +    C + A C NLPG + C C  GY      +  G  C D++EC T +  C  
Sbjct: 1013 VDECRNRSF-CGAHAVCQNLPGSFQCLCDQGYEG----ARDGRHCVDVNECETLQGVC-G 1066

Query: 616  DTICFNLDGGYDCRCPHGKN----CTGDCI 641
              +C N++G + C CP+        TG C+
Sbjct: 1067 AALCENVEGSFLCVCPNSPEEFDPMTGRCV 1096



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 66/207 (31%), Positives = 86/207 (41%), Gaps = 34/207 (16%)

Query: 360  ECKDQTMKLVESSGCPALD------CPESHQITLSHSCCKVCKGYDFCSERHNCMENSI- 412
            EC ++   L +S  C   D      CP  H+     + C      D C ER   +  S  
Sbjct: 886  ECSEED--LCQSGICTNTDGSFECICPPGHRAGPDLASCL---DVDECRERGPALCGSQR 940

Query: 413  CRNL--NDRAVCSCRDGFRALREDNAYCEDIDECAE-GRHYCRENTMCVNTPGSFMCI-- 467
            C N   + R V  C  G+ A  E    C+D+DEC E G   C     C NTPGS+ C   
Sbjct: 941  CENSPGSYRCVRDCDPGYHAGPEGT--CDDVDECQEYGPEICGAQR-CENTPGSYRCTPA 997

Query: 468  CKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKD 527
            C  GY       C + DEC  N+  C  +A+C N  G   C+C  GY            +
Sbjct: 998  CDPGYQPTPGGGCQDVDEC-RNRSFCGAHAVCQNLPGSFQCLCDQGY------------E 1044

Query: 528  GCRNGGACIAANVCACPQGFTGPS-CE 553
            G R+G  C+  N C   QG  G + CE
Sbjct: 1045 GARDGRHCVDVNECETLQGVCGAALCE 1071



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 90/384 (23%), Positives = 127/384 (33%), Gaps = 96/384 (25%)

Query: 395  CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
            C+  D C  R  C  +++C+NL     C C  G+   R D  +C D++EC   +  C   
Sbjct: 1010 CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGAR-DGRHCVDVNECETLQGVCGA- 1067

Query: 455  TMCVNTPGSFMCICKTGYIRIDDYS--CTEHDECITNQHNCDENALCFNTVGGHN----- 507
             +C N  GSF+C+C       D  +  C                A     +         
Sbjct: 1068 ALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPL 1127

Query: 508  ----CVCKPGYTGNGTTCKAF---CKDGCRNGGACIAANV----CACPQGFT-GPSCETD 555
                   + G  G+G     F     D C N    +A NV    C C  G   G  C   
Sbjct: 1128 PRRPSTPRQGPVGSGRRECYFDTAAPDACDN---ILARNVTWQECCCTVGEGWGSGCR-- 1182

Query: 556  IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC--EDIDECGTGRHSC 613
            I +C  G    + ++ C               H  G  +PSG+     D+DEC   R   
Sbjct: 1183 IQQCP-GTETAEYQSLCP--------------HGRGYLAPSGDLSLRRDVDECQLFRDQV 1227

Query: 614  ANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS--VCSCQNGFVM 671
                +C N   GY C C            +G   H  ++  ++ND C+    +C+ G   
Sbjct: 1228 CKSGVCVNTAPGYSCYC-----------SNGYYYHTQRLECIDNDECADEEPACEGG--R 1274

Query: 672  CRRMV----CDCENPTV-----------------------------DLFCCPECDPRLSS 698
            C   V    C CE P V                             DL C     PRL  
Sbjct: 1275 CVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVC---SHPRLDR 1331

Query: 699  QCLHQNGETLYNSGDTWVQNCQQC 722
            Q  +     LY  G+ W  +C  C
Sbjct: 1332 QATYTECCCLY--GEAWGMDCALC 1353



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 38/139 (27%), Positives = 60/139 (43%), Gaps = 5/139 (3%)

Query: 382  SHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDI 441
            +  +T    CC V +G+        C           +++C    G+ A   D +   D+
Sbjct: 1161 ARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEY---QSLCPHGRGYLAPSGDLSLRRDV 1217

Query: 442  DECAEGRHYCRENTMCVNTPGSFMCICKTG-YIRIDDYSCTEHDECITNQHNCDENALCF 500
            DEC   R    ++ +CVNT   + C C  G Y       C ++DEC   +  C E   C 
Sbjct: 1218 DECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPAC-EGGRCV 1276

Query: 501  NTVGGHNCVCKPGYTGNGT 519
            NTVG ++C C+P    +G+
Sbjct: 1277 NTVGSYHCTCEPPLVLDGS 1295



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 49/166 (29%), Positives = 68/166 (40%), Gaps = 26/166 (15%)

Query: 360  ECKDQTMKLVESSGCP--------ALDCPESHQITLSHSCCKV--CKGY--DFCSERHNC 407
            EC+++   L  S  C           DC   +      +C  V  C+ Y  + C  +   
Sbjct: 927  ECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQR-- 984

Query: 408  MENSICRNLNDRAVCS--CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFM 465
                 C N      C+  C  G++        C+D+DEC   R +C  + +C N PGSF 
Sbjct: 985  -----CENTPGSYRCTPACDPGYQPT--PGGGCQDVDEC-RNRSFCGAHAVCQNLPGSFQ 1036

Query: 466  CICKTGYIRI-DDYSCTEHDECITNQHNCDENALCFNTVGGHNCVC 510
            C+C  GY    D   C + +EC T Q  C   ALC N  G   CVC
Sbjct: 1037 CLCDQGYEGARDGRHCVDVNECETLQGVCGA-ALCENVEGSFLCVC 1081



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 26/65 (40%), Positives = 33/65 (50%), Gaps = 3/65 (4%)

Query: 410  NSICRNLNDRAVCSCRDGFRALREDNAYCEDIDEC--AEGRHYCRENTMCVNTPGSFMCI 467
            N  C  + +   C C DG+R L      C DI+EC  AE       N  C+NT GSF CI
Sbjct: 1508 NGRCVRVPEGFTCRCFDGYR-LDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCI 1566

Query: 468  CKTGY 472
            C+ G+
Sbjct: 1567 CRPGF 1571



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 28/81 (34%), Positives = 37/81 (45%), Gaps = 13/81 (16%)

Query: 438  CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRID--DYSCTEHDECITNQHNCD- 494
            C  +D C  GR        CV  P  F C C  GY R+D    +C + +EC   +     
Sbjct: 1500 CGILDGCTNGR--------CVRVPEGFTCRCFDGY-RLDMTRMACVDINECDEAEAASPL 1550

Query: 495  -ENALCFNTVGGHNCVCKPGY 514
              NA C NT G   C+C+PG+
Sbjct: 1551 CVNARCLNTDGSFRCICRPGF 1571



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 32/117 (27%), Positives = 48/117 (41%), Gaps = 13/117 (11%)

Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCS---CRDGFRALREDNAYCEDIDECAEGRHYC 451
           C+G       H+C   S     ++R       C  GF  +   N  CED+DECA G   C
Sbjct: 275 CRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERV---NGSCEDVDECATGGR-C 330

Query: 452 RENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNC 508
           +    C NT G + C+C  G++ +D    +    CI+     +    CF  +    C
Sbjct: 331 QHGE-CANTRGGYTCVCPDGFL-LD----SSRSSCISQHVISEAKGPCFRVLRDGGC 381



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 26/87 (29%), Positives = 38/87 (43%), Gaps = 10/87 (11%)

Query: 550  PSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTG 609
            P  E + +EC  G +   +   C+ +P  + C C DGY        +  +C DI+EC   
Sbjct: 1491 PYEELEAEEC--GILDGCTNGRCVRVPEGFTCRCFDGYR----LDMTRMACVDINECDEA 1544

Query: 610  RHS---CANDTICFNLDGGYDCRCPHG 633
              +   C N   C N DG + C C  G
Sbjct: 1545 EAASPLCVN-ARCLNTDGSFRCICRPG 1570



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 38/132 (28%), Positives = 57/132 (43%), Gaps = 27/132 (20%)

Query: 468 CKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGY--TGNGTTC---- 521
           C TG+ R++  SC + DEC T    C ++  C NT GG+ CVC  G+    + ++C    
Sbjct: 307 CPTGFERVNG-SCEDVDECATGGR-C-QHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 363

Query: 522 -----KAFCKDGCRNGGAC------IAANVCACPQ--GFTGPSCETDIDECSDGFVQCDS 568
                K  C    R+GG        I   +C C +     G  C+      S+GF     
Sbjct: 364 VISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGF----- 418

Query: 569 RANCINLPGWYH 580
           R  C   PG+++
Sbjct: 419 REICPAGPGYHY 430



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 18/35 (51%), Positives = 20/35 (57%), Gaps = 2/35 (5%)

Query: 599 SCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG 633
           SCED+DEC TG      +  C N  GGY C CP G
Sbjct: 317 SCEDVDECATGGRCQHGE--CANTRGGYTCVCPDG 349



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 34/116 (29%), Positives = 44/116 (37%), Gaps = 22/116 (18%)

Query: 499 CFNTVGGHNCVCK-PGYTGNGTTCKA-----------FCKDGCRNGGACIAANVCACPQG 546
           CF  + G  C    PG       C+             C +   N    ++A    CP G
Sbjct: 252 CFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSER-VSAPDGPCPTG 310

Query: 547 F--TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
           F     SCE D+DEC+ G  +C     C N  G Y C C DG+    +   S  SC
Sbjct: 311 FERVNGSCE-DVDECATGG-RCQ-HGECANTRGGYTCVCPDGF----LLDSSRSSC 359



 Score = 35.0 bits (79), Expect = 0.28
 Identities = 23/70 (32%), Positives = 31/70 (44%), Gaps = 11/70 (15%)

Query: 527  DGCRNGGACIAAN---VCACPQGF----TGPSCETDIDECSDGFVQCDS--RANCINLPG 577
            DGC NG  C+       C C  G+    T  +C  DI+EC +          A C+N  G
Sbjct: 1504 DGCTNG-RCVRVPEGFTCRCFDGYRLDMTRMAC-VDINECDEAEAASPLCVNARCLNTDG 1561

Query: 578  WYHCECRDGY 587
             + C CR G+
Sbjct: 1562 SFRCICRPGF 1571



 Score = 34.3 bits (77), Expect = 0.48
 Identities = 11/25 (44%), Positives = 14/25 (56%)

Query: 529 CRNGGACIAANVCACPQGFTGPSCE 553
           C NGG C+  + C CP  F G  C+
Sbjct: 120 CHNGGVCVKPDRCLCPPDFAGKFCQ 144


>gi|110347431 latent transforming growth factor beta binding protein 4
            isoform a [Homo sapiens]
          Length = 1624

 Score =  129 bits (325), Expect = 8e-30
 Identities = 107/394 (27%), Positives = 136/394 (34%), Gaps = 90/394 (22%)

Query: 379  CPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYC 438
            CP  +Q    H     C+  D C++         C+NL     C C  GFR     +A  
Sbjct: 656  CPAGYQAA-PHGAS--CQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRG----SACE 708

Query: 439  EDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENA 497
            ED+DECA+    C     C NT GSF C C  G+  R     C + DEC  +   C    
Sbjct: 709  EDVDECAQEPPPCGPGR-CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGR 767

Query: 498  LCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCE---- 553
             C NT G   CVC  G+  N    +    D C N  AC        P  F   +C     
Sbjct: 768  -CENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHH 826

Query: 554  ------TDIDECSDGFVQCDSRANCINLPGWYHCECRDGY-------------------- 587
                  TD+DECS G   C    +C N  G + C C  GY                    
Sbjct: 827  LHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGD 886

Query: 588  ---------HDNGMFS----------PSGESCEDIDECGTGRHSCANDTICFNLDGGYDC 628
                     + +G F+          P G SC D+DEC           IC N DG ++C
Sbjct: 887  FCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS--EEDLCQSGICTNTDGSFEC 944

Query: 629  RCPHGKNCTGD---CIHDGKVKHNGQIWVLENDRCS--------VCSCQNGFVMCRRMVC 677
             CP G     D   C+   + +  G   +  + RC         V  C  G+       C
Sbjct: 945  ICPPGHRAGPDLASCLDVDECRERGPA-LCGSQRCENSPGSYRCVRDCDPGYHAGPEGTC 1003

Query: 678  D-----------------CENPTVDLFCCPECDP 694
            D                 CEN      C P CDP
Sbjct: 1004 DDVDECQEYGPEICGAQRCENTPGSYRCTPACDP 1037



 Score =  127 bits (320), Expect = 3e-29
 Identities = 86/283 (30%), Positives = 115/283 (40%), Gaps = 34/283 (12%)

Query: 379  CPESHQITLSHSCCKVCKGYDFCSE-RHNCMENSICRNLNDRAVCSCRDGFRALREDNAY 437
            CP  H +         C   D CS     C  +  C N      CSC  G+RA       
Sbjct: 821  CPSGHHLHRGR-----CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGP 875

Query: 438  CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRID-DYSCTEHDECITNQHNCDEN 496
            C D++EC EG  +C  +  C+NT GSF C C  GY       SC + DEC  ++ +  ++
Sbjct: 876  CADVNECLEG-DFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDEC--SEEDLCQS 932

Query: 497  ALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAAN------------VCACP 544
             +C NT G   C+C PG+            D CR  G  +  +            V  C 
Sbjct: 933  GICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCD 992

Query: 545  QGF-TGP--SCETDIDECSDGFVQCDSRANCINLPGWYHCE--CRDGYHDNGMFSPSGES 599
             G+  GP  +C+ D+DEC +   +      C N PG Y C   C  GY         G  
Sbjct: 993  PGYHAGPEGTCD-DVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPT-----PGGG 1046

Query: 600  CEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIH 642
            C+D+DEC   R  C    +C NL G + C C  G     D  H
Sbjct: 1047 CQDVDEC-RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRH 1088



 Score =  124 bits (311), Expect = 4e-28
 Identities = 107/353 (30%), Positives = 136/353 (38%), Gaps = 51/353 (14%)

Query: 422 CSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYS-C 480
           C+C  GFR L      C D+DEC      C     C N+PGSF C+C  G+      + C
Sbjct: 570 CACDSGFR-LSPQGTRCIDVDECRRVPPPCAPGR-CENSPGSFRCVCGPGFRAGPRAAEC 627

Query: 481 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTG--NGTTCKAFCK----DGCRNGGA 534
            + DEC      CD    C NT G   CVC  GY    +G +C+   +     G    GA
Sbjct: 628 LDVDECHRVPPPCDLGR-CENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA 686

Query: 535 CI---AANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNG 591
           C     +  C CP GF G +CE D+DEC+     C     C N  G +HC C  G+   G
Sbjct: 687 CKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPC-GPGRCDNTAGSFHCACPAGFRSRG 745

Query: 592 MFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG--KNCTGDCIHDGKVKHN 649
                G  C+D+DEC      C     C N +G + C CP G   N  G    D     N
Sbjct: 746 ----PGAPCQDVDECARSPPPCTYGR-CENTEGSFQCVCPMGFQPNTAGSECEDVDECEN 800

Query: 650 -----GQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQN 704
                GQ  V         +C +G  + R    D +  +      P C P     C +  
Sbjct: 801 HLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSG---APPCGPH--GHCTNTE 855

Query: 705 GETLYNSGDTWVQNCQQCRCLQG--EVDCWPLPCPDV-EC---EFSILPENEC 751
           G               +C C  G       P PC DV EC   +F   P  EC
Sbjct: 856 GSF-------------RCSCAPGYRAPSGRPGPCADVNECLEGDF-CFPHGEC 894



 Score =  117 bits (292), Expect = 6e-26
 Identities = 88/270 (32%), Positives = 119/270 (44%), Gaps = 35/270 (12%)

Query: 395  CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
            C   + C E   C  +  C N +    C+C  G+R      A C D+DEC+E    C+  
Sbjct: 876  CADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRP-GPRGASCLDVDECSE-EDLCQSG 933

Query: 455  TMCVNTPGSFMCICKTGYIRIDDY-SCTEHDECITNQHNCDENALCFNTVGGHNCV--CK 511
             +C NT GSF CIC  G+    D  SC + DEC         +  C N+ G + CV  C 
Sbjct: 934  -ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCD 992

Query: 512  PGY-TGNGTTCKAFCKDGCRNGGACIA-ANVC-----------ACPQGFT---GPSCETD 555
            PGY  G   TC     D C+  G  I  A  C           AC  G+    G  C+ D
Sbjct: 993  PGYHAGPEGTCDDV--DECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQ-D 1049

Query: 556  IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCAN 615
            +DEC +    C + A C NLPG + C C  GY      +  G  C D++EC T +  C  
Sbjct: 1050 VDECRNRSF-CGAHAVCQNLPGSFQCLCDQGYEG----ARDGRHCVDVNECETLQGVC-G 1103

Query: 616  DTICFNLDGGYDCRCPHGKN----CTGDCI 641
              +C N++G + C CP+        TG C+
Sbjct: 1104 AALCENVEGSFLCVCPNSPEEFDPMTGRCV 1133



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 66/207 (31%), Positives = 86/207 (41%), Gaps = 34/207 (16%)

Query: 360  ECKDQTMKLVESSGCPALD------CPESHQITLSHSCCKVCKGYDFCSERHNCMENSI- 412
            EC ++   L +S  C   D      CP  H+     + C      D C ER   +  S  
Sbjct: 923  ECSEED--LCQSGICTNTDGSFECICPPGHRAGPDLASCL---DVDECRERGPALCGSQR 977

Query: 413  CRNL--NDRAVCSCRDGFRALREDNAYCEDIDECAE-GRHYCRENTMCVNTPGSFMCI-- 467
            C N   + R V  C  G+ A  E    C+D+DEC E G   C     C NTPGS+ C   
Sbjct: 978  CENSPGSYRCVRDCDPGYHAGPEGT--CDDVDECQEYGPEICGAQR-CENTPGSYRCTPA 1034

Query: 468  CKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKD 527
            C  GY       C + DEC  N+  C  +A+C N  G   C+C  GY            +
Sbjct: 1035 CDPGYQPTPGGGCQDVDEC-RNRSFCGAHAVCQNLPGSFQCLCDQGY------------E 1081

Query: 528  GCRNGGACIAANVCACPQGFTGPS-CE 553
            G R+G  C+  N C   QG  G + CE
Sbjct: 1082 GARDGRHCVDVNECETLQGVCGAALCE 1108



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 90/384 (23%), Positives = 127/384 (33%), Gaps = 96/384 (25%)

Query: 395  CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
            C+  D C  R  C  +++C+NL     C C  G+   R D  +C D++EC   +  C   
Sbjct: 1047 CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGAR-DGRHCVDVNECETLQGVCGA- 1104

Query: 455  TMCVNTPGSFMCICKTGYIRIDDYS--CTEHDECITNQHNCDENALCFNTVGGHN----- 507
             +C N  GSF+C+C       D  +  C                A     +         
Sbjct: 1105 ALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPL 1164

Query: 508  ----CVCKPGYTGNGTTCKAF---CKDGCRNGGACIAANV----CACPQGFT-GPSCETD 555
                   + G  G+G     F     D C N    +A NV    C C  G   G  C   
Sbjct: 1165 PRRPSTPRQGPVGSGRRECYFDTAAPDACDN---ILARNVTWQECCCTVGEGWGSGCR-- 1219

Query: 556  IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC--EDIDECGTGRHSC 613
            I +C  G    + ++ C               H  G  +PSG+     D+DEC   R   
Sbjct: 1220 IQQCP-GTETAEYQSLCP--------------HGRGYLAPSGDLSLRRDVDECQLFRDQV 1264

Query: 614  ANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS--VCSCQNGFVM 671
                +C N   GY C C            +G   H  ++  ++ND C+    +C+ G   
Sbjct: 1265 CKSGVCVNTAPGYSCYC-----------SNGYYYHTQRLECIDNDECADEEPACEGG--R 1311

Query: 672  CRRMV----CDCENPTV-----------------------------DLFCCPECDPRLSS 698
            C   V    C CE P V                             DL C     PRL  
Sbjct: 1312 CVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVC---SHPRLDR 1368

Query: 699  QCLHQNGETLYNSGDTWVQNCQQC 722
            Q  +     LY  G+ W  +C  C
Sbjct: 1369 QATYTECCCLY--GEAWGMDCALC 1390



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 38/139 (27%), Positives = 60/139 (43%), Gaps = 5/139 (3%)

Query: 382  SHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDI 441
            +  +T    CC V +G+        C           +++C    G+ A   D +   D+
Sbjct: 1198 ARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEY---QSLCPHGRGYLAPSGDLSLRRDV 1254

Query: 442  DECAEGRHYCRENTMCVNTPGSFMCICKTG-YIRIDDYSCTEHDECITNQHNCDENALCF 500
            DEC   R    ++ +CVNT   + C C  G Y       C ++DEC   +  C E   C 
Sbjct: 1255 DECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPAC-EGGRCV 1313

Query: 501  NTVGGHNCVCKPGYTGNGT 519
            NTVG ++C C+P    +G+
Sbjct: 1314 NTVGSYHCTCEPPLVLDGS 1332



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 49/166 (29%), Positives = 68/166 (40%), Gaps = 26/166 (15%)

Query: 360  ECKDQTMKLVESSGCP--------ALDCPESHQITLSHSCCKV--CKGY--DFCSERHNC 407
            EC+++   L  S  C           DC   +      +C  V  C+ Y  + C  +   
Sbjct: 964  ECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQR-- 1021

Query: 408  MENSICRNLNDRAVCS--CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFM 465
                 C N      C+  C  G++        C+D+DEC   R +C  + +C N PGSF 
Sbjct: 1022 -----CENTPGSYRCTPACDPGYQPT--PGGGCQDVDEC-RNRSFCGAHAVCQNLPGSFQ 1073

Query: 466  CICKTGYIRI-DDYSCTEHDECITNQHNCDENALCFNTVGGHNCVC 510
            C+C  GY    D   C + +EC T Q  C   ALC N  G   CVC
Sbjct: 1074 CLCDQGYEGARDGRHCVDVNECETLQGVCGA-ALCENVEGSFLCVC 1118



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 26/65 (40%), Positives = 33/65 (50%), Gaps = 3/65 (4%)

Query: 410  NSICRNLNDRAVCSCRDGFRALREDNAYCEDIDEC--AEGRHYCRENTMCVNTPGSFMCI 467
            N  C  + +   C C DG+R L      C DI+EC  AE       N  C+NT GSF CI
Sbjct: 1545 NGRCVRVPEGFTCRCFDGYR-LDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCI 1603

Query: 468  CKTGY 472
            C+ G+
Sbjct: 1604 CRPGF 1608



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 28/81 (34%), Positives = 37/81 (45%), Gaps = 13/81 (16%)

Query: 438  CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRID--DYSCTEHDECITNQHNCD- 494
            C  +D C  GR        CV  P  F C C  GY R+D    +C + +EC   +     
Sbjct: 1537 CGILDGCTNGR--------CVRVPEGFTCRCFDGY-RLDMTRMACVDINECDEAEAASPL 1587

Query: 495  -ENALCFNTVGGHNCVCKPGY 514
              NA C NT G   C+C+PG+
Sbjct: 1588 CVNARCLNTDGSFRCICRPGF 1608



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 32/117 (27%), Positives = 48/117 (41%), Gaps = 13/117 (11%)

Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCS---CRDGFRALREDNAYCEDIDECAEGRHYC 451
           C+G       H+C   S     ++R       C  GF  +   N  CED+DECA G   C
Sbjct: 312 CRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERV---NGSCEDVDECATGGR-C 367

Query: 452 RENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNC 508
           +    C NT G + C+C  G++ +D    +    CI+     +    CF  +    C
Sbjct: 368 QHGE-CANTRGGYTCVCPDGFL-LD----SSRSSCISQHVISEAKGPCFRVLRDGGC 418



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 26/87 (29%), Positives = 38/87 (43%), Gaps = 10/87 (11%)

Query: 550  PSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTG 609
            P  E + +EC  G +   +   C+ +P  + C C DGY        +  +C DI+EC   
Sbjct: 1528 PYEELEAEEC--GILDGCTNGRCVRVPEGFTCRCFDGYR----LDMTRMACVDINECDEA 1581

Query: 610  RHS---CANDTICFNLDGGYDCRCPHG 633
              +   C N   C N DG + C C  G
Sbjct: 1582 EAASPLCVN-ARCLNTDGSFRCICRPG 1607



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 38/132 (28%), Positives = 57/132 (43%), Gaps = 27/132 (20%)

Query: 468 CKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGY--TGNGTTC---- 521
           C TG+ R++  SC + DEC T    C ++  C NT GG+ CVC  G+    + ++C    
Sbjct: 344 CPTGFERVNG-SCEDVDECATGGR-C-QHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 400

Query: 522 -----KAFCKDGCRNGGAC------IAANVCACPQ--GFTGPSCETDIDECSDGFVQCDS 568
                K  C    R+GG        I   +C C +     G  C+      S+GF     
Sbjct: 401 VISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGF----- 455

Query: 569 RANCINLPGWYH 580
           R  C   PG+++
Sbjct: 456 REICPAGPGYHY 467



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 18/35 (51%), Positives = 20/35 (57%), Gaps = 2/35 (5%)

Query: 599 SCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG 633
           SCED+DEC TG      +  C N  GGY C CP G
Sbjct: 354 SCEDVDECATGGRCQHGE--CANTRGGYTCVCPDG 386



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 34/116 (29%), Positives = 44/116 (37%), Gaps = 22/116 (18%)

Query: 499 CFNTVGGHNCVCK-PGYTGNGTTCKA-----------FCKDGCRNGGACIAANVCACPQG 546
           CF  + G  C    PG       C+             C +   N    ++A    CP G
Sbjct: 289 CFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSER-VSAPDGPCPTG 347

Query: 547 F--TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
           F     SCE D+DEC+ G  +C     C N  G Y C C DG+    +   S  SC
Sbjct: 348 FERVNGSCE-DVDECATGG-RCQ-HGECANTRGGYTCVCPDGF----LLDSSRSSC 396



 Score = 35.0 bits (79), Expect = 0.28
 Identities = 23/70 (32%), Positives = 31/70 (44%), Gaps = 11/70 (15%)

Query: 527  DGCRNGGACIAAN---VCACPQGF----TGPSCETDIDECSDGFVQCDS--RANCINLPG 577
            DGC NG  C+       C C  G+    T  +C  DI+EC +          A C+N  G
Sbjct: 1541 DGCTNG-RCVRVPEGFTCRCFDGYRLDMTRMAC-VDINECDEAEAASPLCVNARCLNTDG 1598

Query: 578  WYHCECRDGY 587
             + C CR G+
Sbjct: 1599 SFRCICRPGF 1608



 Score = 34.3 bits (77), Expect = 0.48
 Identities = 11/25 (44%), Positives = 14/25 (56%)

Query: 529 CRNGGACIAANVCACPQGFTGPSCE 553
           C NGG C+  + C CP  F G  C+
Sbjct: 157 CHNGGVCVKPDRCLCPPDFAGKFCQ 181


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.138    0.475 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,641,765
Number of Sequences: 37866
Number of extensions: 2008551
Number of successful extensions: 12882
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 206
Number of HSP's successfully gapped in prelim test: 265
Number of HSP's that attempted gapping in prelim test: 5515
Number of HSP's gapped (non-prelim): 2667
length of query: 816
length of database: 18,247,518
effective HSP length: 111
effective length of query: 705
effective length of database: 14,044,392
effective search space: 9901296360
effective search space used: 9901296360
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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