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Search of human proteins with 5453758
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5453758 nebulette sarcomeric isoform [Homo sapiens]
(1014 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5453758 nebulette sarcomeric isoform [Homo sapiens] 2020 0.0
gi|115527120 nebulin [Homo sapiens] 802 0.0
gi|47087157 nebulette non-muscle isoform [Homo sapiens] 201 4e-51
gi|46049092 nebulin-related anchoring protein isoform C [Homo sa... 194 4e-49
gi|46049105 nebulin-related anchoring protein isoform S [Homo sa... 194 4e-49
gi|5453710 LIM and SH3 protein 1 [Homo sapiens] 120 5e-27
gi|169217576 PREDICTED: similar to nebulin [Homo sapiens] 91 4e-18
gi|118498362 kinectin 1 isoform b [Homo sapiens] 66 1e-10
gi|118498368 kinectin 1 isoform c [Homo sapiens] 63 1e-09
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 63 2e-09
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 63 2e-09
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 63 2e-09
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 63 2e-09
gi|239752495 PREDICTED: similar to nebulin [Homo sapiens] 62 2e-09
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 62 3e-09
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 62 3e-09
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 62 3e-09
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 62 3e-09
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 62 3e-09
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 60 1e-08
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 60 1e-08
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 60 1e-08
gi|20357552 cortactin isoform a [Homo sapiens] 59 2e-08
gi|20357556 cortactin isoform b [Homo sapiens] 59 2e-08
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 58 5e-08
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 57 7e-08
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 56 2e-07
gi|19224660 protein kinase C and casein kinase substrate in neur... 55 3e-07
gi|24308229 protein kinase C and casein kinase substrate in neur... 55 3e-07
gi|87299628 biorientation of chromosomes in cell division 1-like... 54 1e-06
>gi|5453758 nebulette sarcomeric isoform [Homo sapiens]
Length = 1014
Score = 2020 bits (5233), Expect = 0.0
Identities = 1014/1014 (100%), Positives = 1014/1014 (100%)
Query: 1 MRVPVFEDIKDETEEEKIGEEENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKK 60
MRVPVFEDIKDETEEEKIGEEENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKK
Sbjct: 1 MRVPVFEDIKDETEEEKIGEEENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKK 60
Query: 61 SKDKCTFVTDSPMLNHVKNIGAFISEAKYKGTIKADLSNSLYKRMPATIDSVFAGEVTQL 120
SKDKCTFVTDSPMLNHVKNIGAFISEAKYKGTIKADLSNSLYKRMPATIDSVFAGEVTQL
Sbjct: 61 SKDKCTFVTDSPMLNHVKNIGAFISEAKYKGTIKADLSNSLYKRMPATIDSVFAGEVTQL 120
Query: 121 QSEVAYKQKHDAAKGFSDYAHMKEPPEVKHAMEVNKHQSNISYRKDVQDTHTYSAELDRP 180
QSEVAYKQKHDAAKGFSDYAHMKEPPEVKHAMEVNKHQSNISYRKDVQDTHTYSAELDRP
Sbjct: 121 QSEVAYKQKHDAAKGFSDYAHMKEPPEVKHAMEVNKHQSNISYRKDVQDTHTYSAELDRP 180
Query: 181 DIKMATQISKIISNAEYKKGQGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMK 240
DIKMATQISKIISNAEYKKGQGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMK
Sbjct: 181 DIKMATQISKIISNAEYKKGQGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMK 240
Query: 241 DKKHHYNPLESASFRQNQLAATLASNVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLS 300
DKKHHYNPLESASFRQNQLAATLASNVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLS
Sbjct: 241 DKKHHYNPLESASFRQNQLAATLASNVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLS 300
Query: 301 GREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSY 360
GREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSY
Sbjct: 301 GREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSY 360
Query: 361 QASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPEFLHVKYITNLLREKEYKKDLENEI 420
QASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPEFLHVKYITNLLREKEYKKDLENEI
Sbjct: 361 QASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPEFLHVKYITNLLREKEYKKDLENEI 420
Query: 421 KGKGMELNSEVLDIQRAKRASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEI 480
KGKGMELNSEVLDIQRAKRASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEI
Sbjct: 421 KGKGMELNSEVLDIQRAKRASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEI 480
Query: 481 ASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSM 540
ASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSM
Sbjct: 481 ASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSM 540
Query: 541 DIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKKEVG 600
DIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKKEVG
Sbjct: 541 DIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKKEVG 600
Query: 601 AGTAVKDSPEIERVKKNQQNISSVKYKEEIKHATAISDPPELKRVKENQKNISNLQYKEQ 660
AGTAVKDSPEIERVKKNQQNISSVKYKEEIKHATAISDPPELKRVKENQKNISNLQYKEQ
Sbjct: 601 AGTAVKDSPEIERVKKNQQNISSVKYKEEIKHATAISDPPELKRVKENQKNISNLQYKEQ 660
Query: 661 NYKATPVSMTPEIERVRRNQEQLSAVKYKGELQRGTAISDPPELKRAKENQKNISNVYYR 720
NYKATPVSMTPEIERVRRNQEQLSAVKYKGELQRGTAISDPPELKRAKENQKNISNVYYR
Sbjct: 661 NYKATPVSMTPEIERVRRNQEQLSAVKYKGELQRGTAISDPPELKRAKENQKNISNVYYR 720
Query: 721 GQLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHI 780
GQLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHI
Sbjct: 721 GQLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHI 780
Query: 781 SMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVD 840
SMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVD
Sbjct: 781 SMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVD 840
Query: 841 LKVWRTDPGSIFDLDPLEDNIQSRSLHMLSEKASHYRRHWSRSHSSSTFGTGLGDDRSEI 900
LKVWRTDPGSIFDLDPLEDNIQSRSLHMLSEKASHYRRHWSRSHSSSTFGTGLGDDRSEI
Sbjct: 841 LKVWRTDPGSIFDLDPLEDNIQSRSLHMLSEKASHYRRHWSRSHSSSTFGTGLGDDRSEI 900
Query: 901 SEIYPSFSCCSEVTRPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYR 960
SEIYPSFSCCSEVTRPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYR
Sbjct: 901 SEIYPSFSCCSEVTRPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYR 960
Query: 961 AMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFVN 1014
AMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFVN
Sbjct: 961 AMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFVN 1014
>gi|115527120 nebulin [Homo sapiens]
Length = 6669
Score = 802 bits (2071), Expect = 0.0
Identities = 462/1088 (42%), Positives = 649/1088 (59%), Gaps = 121/1088 (11%)
Query: 33 VIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKYKGT 92
V +D + LA + T + SD++YKE+ K + C V D+P + K + +SE KYK
Sbjct: 5596 VTDDKNTVLALRNTLIESDLKYKEKHVKERGTCHAVPDTPQILLAKTVSNLVSENKYKDH 5655
Query: 93 IKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMKEPPEVKHAM 152
+K L+ Y +P T D+V EVT+ S+ YK+K KG S+Y+ M EPPEVKHAM
Sbjct: 5656 VKKHLAQGSYTTLPETRDTVHVKEVTKHVSDTNYKKKFVKEKGKSNYSIMLEPPEVKHAM 5715
Query: 153 EVNKHQSNISYRKDVQDTHTYSAELDRPDIKMATQISKIISNAEYK-KGQGIMNKEPAVI 211
EV K QS+++YRKD ++ Y+ DRPDIK ATQ +K S EY+ K + + +++
Sbjct: 5716 EVAKKQSDVAYRKDAKENLHYTTVADRPDIKKATQAAKQASEVEYRAKHRKEGSHGLSML 5775
Query: 212 GRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYKK 271
GRPD E A +A+KLSSQ+KY+E FD E K K YNP +S ++ + A LAS VKYK
Sbjct: 5776 GRPDIEMAKKAAKLSSQVKYRENFDKE-KGKTPKYNPKDSQLYKVMKDANNLASEVKYKA 5834
Query: 272 DIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNA 331
D++ +H PV+D+ L ++HVL S++ S +YKK +E++KG YH D +E LH K
Sbjct: 5835 DLKKLHKPVTDMKESLIMNHVLNTSQLASSYQYKKKYEKSKGHYHTIPDNLEQLHLKEAT 5894
Query: 332 VLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDL 391
LQS VKYKE+YEK +GKPML+F ETP+Y +KE+Q+MQS K Y++D+E+ IKGR+ L
Sbjct: 5895 ELQSIVKYKEKYEKERGKPMLDF-ETPTYITAKESQQMQSGKEYRKDYEESIKGRNLTGL 5953
Query: 392 DKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKK 451
+ TP LHVKY T + EKEY+KDLE I+GKG+ + D+ RAK A+++ +EKEYK+
Sbjct: 5954 EVTPALLHVKYATKIASEKEYRKDLEESIRGKGLTEMEDTPDMLRAKNATQILNEKEYKR 6013
Query: 452 DLESIIKGKGMQAGT------------------------------------DTLEMQHAK 475
DLE +KG+G+ A DT E+ HA+
Sbjct: 6014 DLELEVKGRGLNAMANETPDFMRARNATDIASQIKYKQSAEMEKANFTSVVDTPEIIHAQ 6073
Query: 476 KAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKG 535
+ ++S+K YK D E + + DT ++QR ++ + S QY+ DL+N KGK
Sbjct: 6074 QVKNLSSQKKYKEDAEKSMSY--YETVLDTPEIQRVRENQKNFSLLQYQCDLKNS-KGK- 6129
Query: 536 MQVSMDIPDILRAKRTSEIYSQRKYKDEA---------------------------EKML 568
+ V D P+ILR K + +S YK++ ++ +
Sbjct: 6130 ITVVQDTPEILRVKENQKNFSSVLYKEDVSPGTAIGKTPEMMRVKQTQDHISSVKYKEAI 6189
Query: 569 SNYSTIADTPEIQRIKTTQQNISAVFYKKEVGAGTAVKDSPEIERVKKNQQNISSVKYKE 628
+ I D PE++R+K TQ++IS+V YK+ +G G +PEIERVK+NQ+N SSV YKE
Sbjct: 6190 GQGTPIPDLPEVKRVKETQKHISSVMYKENLGTGIPTTVTPEIERVKRNQENFSSVLYKE 6249
Query: 629 EIKHATAISDPPELKRVKENQKNISNLQYKEQNYKATPVSMTPEIERVRRNQEQLSAVKY 688
+ PE++RVK NQ+N S++ YKE K TP+++TPE+ERV+ NQE +S+V Y
Sbjct: 6250 NLGKGIPTPITPEMERVKRNQENFSSVLYKENMGKGTPLAVTPEMERVKHNQENISSVLY 6309
Query: 689 KGELQRGTAISDPPELKRAKENQKNISNVYYRGQLGRATTLSVTPEMERVKKNQENISSV 748
K + + TA PE++R K NQ+NIS+V Y+ LG+AT TPEMERVK+NQEN SSV
Sbjct: 6310 KENVGKATATPVTPEMQRVKRNQENISSVLYKENLGKATPTPFTPEMERVKRNQENFSSV 6369
Query: 749 KYTQD--------------------------------HKQMKGRPSLILDTPAMRHVKEA 776
Y ++ KQ++G+ + +LDTP MR V+E
Sbjct: 6370 LYKENMRKATPTPVTPEMERAKRNQENISSVLYSDSFRKQIQGKAAYVLDTPEMRRVRET 6429
Query: 777 QNHISMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPG 836
Q HIS VKYHEDFEK KG FTPVV DP+TERV+KN Q SD Y+G+ +VEM+++
Sbjct: 6430 QRHISTVKYHEDFEKHKGC-FTPVVTDPITERVKKNMQDFSDINYRGIQRKVVEMEQKRN 6488
Query: 837 -----IIVDLKVWRTDPGSIFDLDPLEDNIQSRSLHMLSEKASHYRRHWSRSHSSSTFGT 891
I L+VWRT+PGS+FD DP EDNIQSRSLHM++ +A RR +S S+S
Sbjct: 6489 DQDQETITGLRVWRTNPGSVFDYDPAEDNIQSRSLHMINVQAQ--RRSREQSRSASALSI 6546
Query: 892 GLGDDRSEISEIYPSFSCCSEVTRPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMR--- 948
G+++SE SE ++ SD G + AY+ + + +SV++ +
Sbjct: 6547 SGGEEKSEHSEAPDH-----HLSTYSDGGVFAVSTAYKHAKTTELPQQRSSSVATQQTTV 6601
Query: 949 -SMQHSPNL--RTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGML 1005
S+ P+ + +RAMYDY A D DEVSF+DGD I+NVQ ID+GWMYGTVQRTGRTGML
Sbjct: 6602 SSIPSHPSTAGKIFRAMYDYMAADADEVSFKDGDAIINVQAIDEGWMYGTVQRTGRTGML 6661
Query: 1006 PANYIEFV 1013
PANY+E +
Sbjct: 6662 PANYVEAI 6669
Score = 408 bits (1048), Expect = e-113
Identities = 319/1011 (31%), Positives = 471/1011 (46%), Gaps = 219/1011 (21%)
Query: 4 PVFEDIKDETE--EEKIGEEENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKS 61
P+ K T+ EK + E+ + Y V+++ LA+ + IS I+Y++ ++KS
Sbjct: 5389 PINRHFKYATQLMNEKKYRADYEQRKDKYHLVVDEPRHLLAKTAGDQISQIKYRKNYEKS 5448
Query: 62 KDKCTFVT------------------------------------DSPMLNHVKNIGAFIS 85
KDK T + D+PML HV+ + +S
Sbjct: 5449 KDKFTSIVDTPEHLRTTKVNKQISDILYKLEYNKAKPRGYTTIHDTPMLLHVRKVKDEVS 5508
Query: 86 EAKYKGTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMK-- 143
+ KYK + + SN + P + A + ++ + + YK++++A K AH K
Sbjct: 5509 DLKYKEVYQRNKSNCTIE--PDAVHIKAAKDAYKVNTNLDYKKQYEANK-----AHWKWT 5561
Query: 144 -EPPEVKHAMEVNKHQSNISYR------------------------------------KD 166
+ P+ A + + QS+ Y+ K
Sbjct: 5562 PDRPDFLQAAKSSLQQSDFEYKLDREFLKGCKLSVTDDKNTVLALRNTLIESDLKYKEKH 5621
Query: 167 VQDTHTYSAELDRPDIKMATQISKIISNAEYKK------GQGIMNKEPAVIGRPDFEHAV 220
V++ T A D P I +A +S ++S +YK QG P D H
Sbjct: 5622 VKERGTCHAVPDTPQILLAKTVSNLVSENKYKDHVKKHLAQGSYTTLPET---RDTVHVK 5678
Query: 221 EASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYKKDI-QNMH-D 278
E +K S YK+KF E K K ++ LE + A S+V Y+KD +N+H
Sbjct: 5679 EVTKHVSDTNYKKKFVKE-KGKSNYSIMLEPPEVKHAMEVAKKQSDVAYRKDAKENLHYT 5737
Query: 279 PVSDLPNLLFLDHVLKASKMLSGREY--KKLFEENKGMYHFDADAVEHLHHKGNAVLQSQ 336
V+D P+ + +A+K S EY K E + G+ +E K A L SQ
Sbjct: 5738 TVADRPD---IKKATQAAKQASEVEYRAKHRKEGSHGLSMLGRPDIEMA--KKAAKLSSQ 5792
Query: 337 VKYKEEYEKNKGK-PMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSL------ 389
VKY+E ++K KGK P ++ Y+ K+A + SE YK D +K K + +
Sbjct: 5793 VKYRENFDKEKGKTPKYNPKDSQLYKVMKDANNLASEVKYKADLKKLHKPVTDMKESLIM 5852
Query: 390 ---------------------------DLDKTPEFLHVKYITNLLREKEYKKDLENEIKG 422
+ E LH+K T L +YK+ E E +G
Sbjct: 5853 NHVLNTSQLASSYQYKKKYEKSKGHYHTIPDNLEQLHLKEATELQSIVKYKEKYEKE-RG 5911
Query: 423 KGMELNSEVLDIQRAKRASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEIAS 482
K M L+ E AK + +M S KEY+KD E IKG+ + T + H K A +IAS
Sbjct: 5912 KPM-LDFETPTYITAKESQQMQSGKEYRKDYEESIKGRNLTGLEVTPALLHVKYATKIAS 5970
Query: 483 EKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVS--- 539
EK+Y++DLE I+GKG+ DT D+ RAK A+++ ++K+YK+DLE E+KG+G+
Sbjct: 5971 EKEYRKDLEESIRGKGLTEMEDTPDMLRAKNATQILNEKEYKRDLELEVKGRGLNAMANE 6030
Query: 540 ---------------------------------MDIPDILRAKRTSEIYSQRKYKDEAEK 566
+D P+I+ A++ + SQ+KYK++AEK
Sbjct: 6031 TPDFMRARNATDIASQIKYKQSAEMEKANFTSVVDTPEIIHAQQVKNLSSQKKYKEDAEK 6090
Query: 567 MLSNYSTIADTPEIQ-----------------------------------RIKTTQQNIS 591
+S Y T+ DTPEIQ R+K Q+N S
Sbjct: 6091 SMSYYETVLDTPEIQRVRENQKNFSLLQYQCDLKNSKGKITVVQDTPEILRVKENQKNFS 6150
Query: 592 AVFYKKEVGAGTAVKDSPEIERVKKNQQNISSVKYKEEIKHATAISDPPELKRVKENQKN 651
+V YK++V GTA+ +PE+ RVK+ Q +ISSVKYKE I T I D PE+KRVKE QK+
Sbjct: 6151 SVLYKEDVSPGTAIGKTPEMMRVKQTQDHISSVKYKEAIGQGTPIPDLPEVKRVKETQKH 6210
Query: 652 ISNLQYKEQNYKATPVSMTPEIERVRRNQEQLSAVKYKGELQRGTAISDPPELKRAKENQ 711
IS++ YKE P ++TPEIERV+RNQE S+V YK L +G PE++R K NQ
Sbjct: 6211 ISSVMYKENLGTGIPTTVTPEIERVKRNQENFSSVLYKENLGKGIPTPITPEMERVKRNQ 6270
Query: 712 KNISNVYYRGQLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMR 771
+N S+V Y+ +G+ T L+VTPEMERVK NQENISSV Y K+ G+ + TP M+
Sbjct: 6271 ENFSSVLYKENMGKGTPLAVTPEMERVKHNQENISSVLY----KENVGKATATPVTPEMQ 6326
Query: 772 HVKEAQNHISMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYK 822
VK Q +IS V Y E+ K FTP + ERV++N + S YK
Sbjct: 6327 RVKRNQENISSVLYKENLGKATPTPFTPEM-----ERVKRNQENFSSVLYK 6372
Score = 209 bits (533), Expect = 8e-54
Identities = 220/895 (24%), Positives = 378/895 (42%), Gaps = 129/895 (14%)
Query: 30 YKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKY 89
++ V++ + LA+ + SD++YKE F K+K K TF D+P ++H K++G S Y
Sbjct: 4400 FRSVVDPPEIVLAKINSVNQSDVKYKETFNKAKGKYTFSPDTPHISHSKDMGKLYSTILY 4459
Query: 90 KGTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKG-FSDYAHMKEPPEV 148
KG + + Y I V A + SE+ YK+ ++ KG + + E P V
Sbjct: 4460 KGAWEGTKAYG-YTLDERYIPIVGAKHADLVNSELKYKETYEKQKGHYLAGKVIGEFPGV 4518
Query: 149 KHAMEVNKHQSNISYRKDVQDT--------------------------------HTYSAE 176
H ++ K +S ++YRK +DT H +++
Sbjct: 4519 VHCLDFQKMRSALNYRKHYEDTKANVHIPNDMMNHVLAKRCQYILSDLEYRHYFHQWTSL 4578
Query: 177 LDRPDIKMATQISKIISNAEYK------KGQGIMNKEPAVIGRPDFEHAVEASKLSSQIK 230
L+ P++ +I+S+ YK KG G V P HA ++ L SQ++
Sbjct: 4579 LEEPNVIRVRNAQEILSDNVYKDDLNWLKGIGCY-----VWDTPQILHAKKSYDLQSQLQ 4633
Query: 231 YKEKFDNEMKDKKHHYNPLESASFRQNQLAATL-ASNVKYKKDIQNMHDPVSDLPNLLFL 289
Y K+ +YN + + + + AS VKYK++ + D + + +
Sbjct: 4634 YTA----AGKENLQNYNLVTDTPLYVTAVQSGINASEVKYKENYHQIKDKYTTVLETVDY 4689
Query: 290 DHVLKASKMLSGREYKKLFEENKG-MYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKG 348
D + S YK+ ++ K Y + + H K L S +KY+EEYEK K
Sbjct: 4690 DRTRNLKNLYSSNLYKEAWDRVKATSYILPSSTLSLTHAKNQKHLASHIKYREEYEKFKA 4749
Query: 349 KPML--EFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPEFLHVKYITNL 406
L + P+ K+ +++Y+ +EK K + + D E + K
Sbjct: 4750 LYTLPRSVDDDPNTARCLRVGKLNIDRLYRSVYEKN-KMKIHIVPDMV-EMVTAKDSQKK 4807
Query: 407 LREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKKDLESIIKGKGMQAGT 466
+ E +Y+ L I +++N V ++ ++ S+ YK DL + +KG G
Sbjct: 4808 VSEIDYRLRLHEWICHPDLQVNDHV------RKVTDQISDIVYKDDL-NWLKGIGCYV-W 4859
Query: 467 DTLEMQHAKKAAEIASEKDYKRD-LETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKK 525
DT E+ HAK A ++ + YK L+T ++ TDT +A K+ + S Y
Sbjct: 4860 DTPEILHAKHAYDLRDDIKYKAHMLKTR---NDYKLVTDTPVYVQAVKSGKQLSDAVYHY 4916
Query: 526 DLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKT 585
D + ++GK + + D+ RA ++ S YK + + Y DTP + IK
Sbjct: 4917 DYVHSVRGKVAPTTKTV-DLDRALHAYKLQSSNLYKTSLRTLPTGYRLPGDTPHFKHIKD 4975
Query: 586 TQQNISAVFYK------KEVGAGTAVKDSPEIERVKKNQQNISSVKYKEEIKHAT----- 634
T+ S YK K G KD P + + N N++S + E+ H
Sbjct: 4976 TRYMSSYFKYKEAYEHTKAYGYTLGPKDVPFVHVRRVN--NVTSERLYRELYHKLKDKIH 5033
Query: 635 AISDPPELKRVKENQKNISNLQYKEQNYK----ATPVSMTPEIERVRRNQEQLSAVKYKG 690
D PE+++VK+ Q+ +S L YK +K + TP++ R + S +KYK
Sbjct: 5034 TTPDTPEIRQVKKTQEAVSELIYKSDFFKMQGHMISLPYTPQVIHCRYVGDITSDIKYKE 5093
Query: 691 ELQ----RGTAISDPPELKRAKENQKNISNVYY----RGQLGRATTLSVTPEMERVKKNQ 742
+LQ G + D P++ R++ +K SN Y R + + TPE +V++ +
Sbjct: 5094 DLQVLKGFGCFLYDTPDMVRSRHLRKLWSNYLYTDKARKMRDKYKVVLDTPEYRKVQELK 5153
Query: 743 ENISSVKYTQDHKQMKGRPSLILDTP---------------------------------- 768
++S + Y K+ K + + DTP
Sbjct: 5154 THLSELVYRAAGKKQKSIFTSVPDTPDLLRAKRGQKLQSQYLYVELATKERPHHHAGNQT 5213
Query: 769 -AMRHVKEAQNHISMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYK 822
A++H K+ ++ +S KY +EK K + +TPV D P+ R ++ SD YK
Sbjct: 5214 TALKHAKDVKDMVSEKKYKIQYEKMKDK-YTPVPDTPILIRAKRAYWNASDLRYK 5267
Score = 207 bits (528), Expect = 3e-53
Identities = 215/847 (25%), Positives = 385/847 (45%), Gaps = 66/847 (7%)
Query: 7 EDIKDETEEEKIGEEENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCT 66
+ KD T K+ ++ + QV PV+ + ++ +SD+ YK + + K KC
Sbjct: 486 DQCKDHTY--KVHPDKTKFTQVTDSPVLLQAQVN-----SKQLSDLNYKAKHESEKFKCH 538
Query: 67 FVTDSPMLNHVKNIGAFISEAKYKGTIKADLSNSLYKRMPATIDSV---FAGEVTQLQSE 123
D+P K +S+ YK D S K+ +D++ A T+ S+
Sbjct: 539 IPPDTPAFIQHKVNAYNLSDNLYK----QDWEKSKAKKFDIKVDAIPLLAAKANTKNTSD 594
Query: 124 VAYKQKHDAAKG-FSDYAHMKEPPEVKHAMEVNKHQSNISYRKDVQDTHTYSAEL-DRPD 181
V YK+ ++ KG + + P++ H+++V K+QS+ Y+++ + T S + P
Sbjct: 595 VMYKKDYEKNKGKMIGVLSINDDPKMLHSLKVAKNQSDRLYKENYEKTKAKSMNYCETPK 654
Query: 182 IKMATQISKIISNAEYKK--GQGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEM 239
++ TQ+ K S A YK + ++ + P H ++ + +S YK +++ +
Sbjct: 655 YQLDTQL-KNFSEARYKDLYVKDVLGHYVGSMEDPYHTHCMKVAAQNSDKSYKAEYEED- 712
Query: 240 KDKKHHYNPLESASFRQNQLAATLASNVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKML 299
K K + + +L K D + V+D P LL +K L
Sbjct: 713 KGKCYFPQTITQEYEAIKKLDQCKDHTYKVHPD-KTKFTAVTDSPVLL---QAQLNTKQL 768
Query: 300 SGREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPS 359
S YK E K H ADA + + H+ NA S YK+++EK+K K V+
Sbjct: 769 SDLNYKAKHEGEKFKCHIPADAPQFIQHRVNAYNLSDNVYKQDWEKSKAKKFDIKVDAIP 828
Query: 360 YQASKEAQKMQSEKVYKEDFEKEIKGR--SSLDLDKTPEFLHVKYITNLLREKEYKKDLE 417
A+K K S+ +YK+D+EK KG+ +L ++ P+ LH ++EY+KD E
Sbjct: 829 LLAAKANTKNTSDVMYKKDYEKS-KGKMIGALSINDDPKMLHSLKTAKNQSDREYRKDYE 887
Query: 418 NEIKGKGM-ELNSEVLDIQRAKRASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKK 476
K K + ++L + +AK++ +AS+ +YK L S D++ + AKK
Sbjct: 888 ---KSKTIYTAPLDMLQVTQAKKSQAIASDVDYKHILHS------YSYPPDSINVDLAKK 938
Query: 477 AAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGM 536
A + S+ +YK D + +KG G V +L++++AK+AS++ ++K+Y++ + +K +
Sbjct: 939 AYALQSDVEYKADYNSWMKGCGW-VPFGSLEMEKAKRASDILNEKKYRQH-PDTLKFTSI 996
Query: 537 QVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYK 596
+ D P +++K S YK + E+++ Y+ D P+ + K NIS YK
Sbjct: 997 E---DAPITVQSKINQAQRSDIAYKAKGEEIIHKYNLPPDLPQFIQAKVNAYNISENMYK 1053
Query: 597 KEV----GAGTAVK-DSPEIERVKKNQQNISSVKYKEEIKHA-------TAISDPPELKR 644
++ G ++ D+ I K +Q S V+YK++ + A ++ D P+L
Sbjct: 1054 ADLKDLSKKGYDLRTDAIPIRAAKAARQAASDVQYKKDYEKAKGKMVGFQSLQDDPKLVH 1113
Query: 645 VKENQKNISNLQYKEQNYKATPVSMTP----EIERVRRNQEQLSAVKYKGELQRGTAISD 700
K S+ +YK+ K TP + ++ Q+ +S V YK L T + D
Sbjct: 1114 YMNVAKIQSDREYKKDYEKTKSKYNTPHDMFNVVAAKKAQDVVSNVNYKHSLHHYTYLPD 1173
Query: 701 PPELKRAKE-NQKNISNVYYRGQLGRATTLSVTP----EMERVKKNQENISSVKYTQDHK 755
+L+ +K Q NVY + P ++E+VKK + ++ KY Q
Sbjct: 1174 AMDLELSKNMMQIQSDNVYKEDYNNWMKGIGWIPIGSLDVEKVKKAGDALNEKKYRQHPD 1233
Query: 756 QMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQV 815
+K + I+D+P M K+ +S + Y E K + +T D P + + N
Sbjct: 1234 TLKF--TSIVDSPVMVQAKQNTKQVSDILYKAKGEDVKHK-YTMSPDLPQFLQAKCNAYN 1290
Query: 816 VSDAAYK 822
+SD YK
Sbjct: 1291 ISDVCYK 1297
Score = 204 bits (520), Expect = 3e-52
Identities = 225/855 (26%), Positives = 376/855 (43%), Gaps = 95/855 (11%)
Query: 42 ARKCTELISDIRYKEEFKKSKDK-CTFVTDSPMLNHVKNIGAFISEAKYKGTIKADLSNS 100
++K +L S +YKE+F+K+K + TD+P L +K + +SE KY+ + D++ +
Sbjct: 89 SQKMQDLFSPNKYKEKFEKTKGQPYASTTDTPELRRIKKVQDQLSEVKYR--MDGDVAKT 146
Query: 101 LYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMKEPPEVKHAMEVNKHQSN 160
+ D A +V+Q S+V YKQ + K Y + PE+ A++ S
Sbjct: 147 ICHVDEKAKDIEHAKKVSQQVSKVLYKQNWEDTK--DKYLLPPDAPELVQAVKNTAMFSK 204
Query: 161 ISYRKDVQ-DTHTYSAELDRPDIKMATQISKIISNAEYKKGQGIMNKE-PAVIGRPDFEH 218
Y +D + D + D P+++ Q K +S+ YKKG + + PD E
Sbjct: 205 KLYTEDWEADKSLFYPYNDSPELRRVAQAQKALSDVAYKKGLAEQQAQFTPLADPPDIEF 264
Query: 219 AVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYKKDIQNMHD 278
A + + S+ KYKE ++N++K K E A+ R N A S KY++D +NM D
Sbjct: 265 AKKVTNQVSKQKYKEDYENKIKGKWSETPCFEVANARMN---ADNISTRKYQEDFENMKD 321
Query: 279 PV----SDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDA------DAVEHLHHK 328
+ ++ P KA S +YK+ +E+NKG ++ + L
Sbjct: 322 QIYFMQTETPEYKMNK---KAGVAASKVKYKEDYEKNKGKADYNVLPASENPQLRQLKAA 378
Query: 329 GNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSS 388
G+A+ S YKE YEK K K + + ETP ++ Q S+K YK+ + K+I G
Sbjct: 379 GDAL--SDKLYKENYEKTKAK-SINYCETPKFKLDTVLQNFSSDKKYKDSYLKDILGH-Y 434
Query: 389 LDLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGM-------------ELN------- 428
+ + P H +T +K YK + E E +GKG +L+
Sbjct: 435 VGSFEDPYHSHCMKVTAQNSDKNYKAEYE-EDRGKGFFPQTITQEYEAIKKLDQCKDHTY 493
Query: 429 ---------SEVLD---IQRAKRASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKK 476
++V D + +A+ S+ S+ YK ES + DT K
Sbjct: 494 KVHPDKTKFTQVTDSPVLLQAQVNSKQLSDLNYKAKHES--EKFKCHIPPDTPAFIQHKV 551
Query: 477 AAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGK-- 534
A S+ YK+D E + K K + D + + AK ++ S YKKD E KGK
Sbjct: 552 NAYNLSDNLYKQDWE-KSKAKKFDIKVDAIPLLAAKANTKNTSDVMYKKDYEKN-KGKMI 609
Query: 535 GMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVF 594
G+ D P +L + + ++ S R YK+ EK + +TP+ Q + T +N S
Sbjct: 610 GVLSINDDPKMLHSLKVAKNQSDRLYKENYEKTKAKSMNYCETPKYQ-LDTQLKNFSEAR 668
Query: 595 YK----KEV-GAGTAVKDSPEIERVKKNQQNISSVKYKEEIKHATAISDPPELKRVKENQ 649
YK K+V G + P K S YK E + P+ + +
Sbjct: 669 YKDLYVKDVLGHYVGSMEDPYHTHCMKVAAQNSDKSYKAEYEEDKGKCYFPQ--TITQEY 726
Query: 650 KNISNL-QYKEQNYKATP-------VSMTPEIERVRRNQEQLSAVKYK----GELQRGTA 697
+ I L Q K+ YK P V+ +P + + + N +QLS + YK GE +
Sbjct: 727 EAIKKLDQCKDHTYKVHPDKTKFTAVTDSPVLLQAQLNTKQLSDLNYKAKHEGEKFKCHI 786
Query: 698 ISDPPELKRAKENQKNISNVYYRGQLGRATTLSVTPEMERV-----KKNQENISSVKYTQ 752
+D P+ + + N N+S+ Y+ ++ +++ + K N +N S V Y +
Sbjct: 787 PADAPQFIQHRVNAYNLSDNVYKQDWEKSKAKKFDIKVDAIPLLAAKANTKNTSDVMYKK 846
Query: 753 DHKQMKGR---PSLILDTPAMRHVKEAQNHISMVKYHEDFEKTKGRGFTPVVDDPVTERV 809
D+++ KG+ I D P M H + + S +Y +D+EK+K +T +D +
Sbjct: 847 DYEKSKGKMIGALSINDDPKMLHSLKTAKNQSDREYRKDYEKSK-TIYTAPLDMLQVTQA 905
Query: 810 RKNTQVVSDAAYKGV 824
+K+ + SD YK +
Sbjct: 906 KKSQAIASDVDYKHI 920
Score = 202 bits (515), Expect = 1e-51
Identities = 224/922 (24%), Positives = 401/922 (43%), Gaps = 127/922 (13%)
Query: 7 EDIKDETEEEKIG-EEENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKC 65
+D+KD E+K + E +D+ Y PV + + A++ SD+RYKE F+K+K K
Sbjct: 5220 KDVKDMVSEKKYKIQYEKMKDK--YTPVPDTPILIRAKRAYWNASDLRYKETFQKTKGKY 5277
Query: 66 TFVTDSPMLNHVKNIGAFISEAKYKGTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVA 125
V D+ + + + + IS+ KYK + L +++ +P + VT S+V
Sbjct: 5278 HTVKDALDIVYHRKVTDDISKIKYKENYMSQL--GIWRSIPDRPEHFHHRAVTDTVSDVK 5335
Query: 126 YKQKHDAAKGFSDYAHMKEPPEVKHAMEVNKHQSNISYRKDVQDTHT-YSAELDRP---D 181
YK+ KG YA+ + P+ A + S Y++ + T + + D P
Sbjct: 5336 YKEDLTWLKGIGCYAY--DTPDFTLAEKNKTLYSKYKYKEVFERTKSDFKYVADSPINRH 5393
Query: 182 IKMATQI---SKIISNAEYKKGQGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNE 238
K ATQ+ K ++ E +K +K V+ P A A SQIKY++ ++ +
Sbjct: 5394 FKYATQLMNEKKYRADYEQRK-----DKYHLVVDEPRHLLAKTAGDQISQIKYRKNYE-K 5447
Query: 239 MKDKKHHY--NPLESASFRQNQLAATLASNVKYKKDIQNMHDPVSDLPNLLFLDHVLKAS 296
KDK P + + N+ + + ++Y K + + D P LL HV K
Sbjct: 5448 SKDKFTSIVDTPEHLRTTKVNKQISDILYKLEYNKAKPRGYTTIHDTPMLL---HVRKVK 5504
Query: 297 KMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVE 356
+S +YK++++ NK + DAV K + + + YK++YE NK +
Sbjct: 5505 DEVSDLKYKEVYQRNKSNCTIEPDAVHIKAAKDAYKVNTNLDYKKQYEANKAH-WKWTPD 5563
Query: 357 TPSYQASKEAQKMQSEKVYKED--------------------------------FEKEIK 384
P + + ++ QS+ YK D EK +K
Sbjct: 5564 RPDFLQAAKSSLQQSDFEYKLDREFLKGCKLSVTDDKNTVLALRNTLIESDLKYKEKHVK 5623
Query: 385 GRSSLD-LDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEM 443
R + + TP+ L K ++NL+ E +YK ++ + E D K ++
Sbjct: 5624 ERGTCHAVPDTPQILLAKTVSNLVSENKYKDHVKKHLAQGSYTTLPETRDTVHVKEVTKH 5683
Query: 444 ASEKEYKKDLESIIKGKGMQAGTDTLE-------MQHAKKAAEIASEKDYKRDL------ 490
S+ YKK +K KG + LE M+ AKK +++A KD K +L
Sbjct: 5684 VSDTNYKK---KFVKEKGKSNYSIMLEPPEVKHAMEVAKKQSDVAYRKDAKENLHYTTVA 5740
Query: 491 ----------------ETEIKGKGMQVSTDTL------DVQRAKKASEMASQKQYKKDLE 528
E E + K + + L D++ AKKA++++SQ +Y+++ +
Sbjct: 5741 DRPDIKKATQAAKQASEVEYRAKHRKEGSHGLSMLGRPDIEMAKKAAKLSSQVKYRENFD 5800
Query: 529 NEIKGKGMQVSMDIPDILRA-KRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQ 587
E KGK + + + + K + + S+ KYK + +K+ + + ++ + + T
Sbjct: 5801 KE-KGKTPKYNPKDSQLYKVMKDANNLASEVKYKADLKKLHKPVTDMKESLIMNHVLNTS 5859
Query: 588 QNISAVFYKKEV----GAGTAVKDSPEIERVKKNQQNISSVKYKEEIKHATAIS----DP 639
Q S+ YKK+ G + D+ E +K+ + S VKYKE+ + +
Sbjct: 5860 QLASSYQYKKKYEKSKGHYHTIPDNLEQLHLKEATELQSIVKYKEKYEKERGKPMLDFET 5919
Query: 640 PELKRVKENQKNISNLQYK---EQNYKA---TPVSMTPEIERVRRNQEQLSAVKYKGELQ 693
P KE+Q+ S +Y+ E++ K T + +TP + V+ + S +Y+ +L+
Sbjct: 5920 PTYITAKESQQMQSGKEYRKDYEESIKGRNLTGLEVTPALLHVKYATKIASEKEYRKDLE 5979
Query: 694 RG------TAISDPPELKRAKENQKNISNVYYRGQL-------GRATTLSVTPEMERVKK 740
T + D P++ RAK + ++ Y+ L G + TP+ R +
Sbjct: 5980 ESIRGKGLTEMEDTPDMLRAKNATQILNEKEYKRDLELEVKGRGLNAMANETPDFMRARN 6039
Query: 741 NQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEKTKGRGFTPV 800
+ S +KY Q + K + ++DTP + H ++ +N S KY ED EK+ + V
Sbjct: 6040 ATDIASQIKYKQSAEMEKANFTSVVDTPEIIHAQQVKNLSSQKKYKEDAEKSMSY-YETV 6098
Query: 801 VDDPVTERVRKNTQVVSDAAYK 822
+D P +RVR+N + S Y+
Sbjct: 6099 LDTPEIQRVRENQKNFSLLQYQ 6120
Score = 200 bits (508), Expect = 6e-51
Identities = 214/887 (24%), Positives = 368/887 (41%), Gaps = 119/887 (13%)
Query: 35 EDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKYKGTIK 94
+D+ R+ + S+ Y+E + K KDK D+P + VK +SE YK
Sbjct: 5002 KDVPFVHVRRVNNVTSERLYRELYHKLKDKIHTTPDTPEIRQVKKTQEAVSELIYKSDFF 5061
Query: 95 ADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMKEPPEVKHAMEV 154
+ + +P T + V + S++ YK+ KGF + + + P++ + +
Sbjct: 5062 KMQGHMI--SLPYTPQVIHCRYVGDITSDIKYKEDLQVLKGFGCFLY--DTPDMVRSRHL 5117
Query: 155 NKHQSNISYRKDVQDTHT-YSAELDRPDIK----MATQISKIISNAEYKKGQGIMNKEPA 209
K SN Y + Y LD P+ + + T +S+++ A KK + I P
Sbjct: 5118 RKLWSNYLYTDKARKMRDKYKVVLDTPEYRKVQELKTHLSELVYRAAGKKQKSIFTSVPD 5177
Query: 210 VIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKY 269
PD A KL SQ Y E K++ HH+ ++ + + + + S KY
Sbjct: 5178 T---PDLLRAKRGQKLQSQYLYVEL---ATKERPHHHAGNQTTALKHAKDVKDMVSEKKY 5231
Query: 270 KKDIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKG 329
K + M D + +P+ L +A S YK+ F++ KG YH DA++ ++H+
Sbjct: 5232 KIQYEKMKDKYTPVPDTPILIRAKRAYWNASDLRYKETFQKTKGKYHTVKDALDIVYHRK 5291
Query: 330 NAVLQSQVKYKEEYEKNKG--------------------------KPMLEFV-------- 355
S++KYKE Y G K L ++
Sbjct: 5292 VTDDISKIKYKENYMSQLGIWRSIPDRPEHFHHRAVTDTVSDVKYKEDLTWLKGIGCYAY 5351
Query: 356 ETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPEFLHVKYITNLLREKEYKKD 415
+TP + +++ + + S+ YKE FE+ K D +P H KY T L+ EK+Y+ D
Sbjct: 5352 DTPDFTLAEKNKTLYSKYKYKEVFER-TKSDFKYVAD-SPINRHFKYATQLMNEKKYRAD 5409
Query: 416 LENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKKDLE-------SII----------- 457
E K K + E + AK A + S+ +Y+K+ E SI+
Sbjct: 5410 YEQR-KDKYHLVVDEPRHL-LAKTAGDQISQIKYRKNYEKSKDKFTSIVDTPEHLRTTKV 5467
Query: 458 ----------------KGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQV 501
K +G DT + H +K + S+ YK + +
Sbjct: 5468 NKQISDILYKLEYNKAKPRGYTTIHDTPMLLHVRKVKDEVSDLKYKEVYQR--NKSNCTI 5525
Query: 502 STDTLDVQRAKKASEMASQKQYKKDLE-NEIKGKGMQVSMDIPDILRAKRTSEIYSQRKY 560
D + ++ AK A ++ + YKK E N+ K + D PD L+A ++S S +Y
Sbjct: 5526 EPDAVHIKAAKDAYKVNTNLDYKKQYEANKAHWKW---TPDRPDFLQAAKSSLQQSDFEY 5582
Query: 561 KDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYK----KEVGAGTAVKDSPEIERVKK 616
K + E + ++ D S + YK KE G AV D+P+I K
Sbjct: 5583 KLDREFLKGCKLSVTDDKNTVLALRNTLIESDLKYKEKHVKERGTCHAVPDTPQILLAKT 5642
Query: 617 NQQNISSVKYKEEIK------HATAISDPPELKRVKENQKNISNLQYKEQNYKATPVS-- 668
+S KYK+ +K T + + + VKE K++S+ YK++ K S
Sbjct: 5643 VSNLVSENKYKDHVKKHLAQGSYTTLPETRDTVHVKEVTKHVSDTNYKKKFVKEKGKSNY 5702
Query: 669 ----MTPEIERVRRNQEQLSAVKYKGELQRG---TAISDPPELKRAKENQKNISNVYYRG 721
PE++ ++ S V Y+ + + T ++D P++K+A + K S V YR
Sbjct: 5703 SIMLEPPEVKHAMEVAKKQSDVAYRKDAKENLHYTTVADRPDIKKATQAAKQASEVEYRA 5762
Query: 722 QLGRATTLSVT----PEMERVKKNQENISSVKYTQDHKQMKGRPSLI--LDTPAMRHVKE 775
+ + + ++ P++E KK + S VKY ++ + KG+ D+ + +K+
Sbjct: 5763 KHRKEGSHGLSMLGRPDIEMAKKAAKLSSQVKYRENFDKEKGKTPKYNPKDSQLYKVMKD 5822
Query: 776 AQNHISMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYK 822
A N S VKY D +K + T + + + V +Q+ S YK
Sbjct: 5823 ANNLASEVKYKADLKKLH-KPVTDMKESLIMNHVLNTSQLASSYQYK 5868
Score = 194 bits (493), Expect = 4e-49
Identities = 216/902 (23%), Positives = 395/902 (43%), Gaps = 99/902 (10%)
Query: 16 EKIGEEENEE------DQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVT 69
+K G+ NE D V + V + + M LA+ T+ +SD+ YK E +K K K T
Sbjct: 1461 KKAGDALNERKYRQHPDTVKFTSVPDSMGMVLAQHNTKQLSDLNYKVEGEKLKHKYTIDP 1520
Query: 70 DSPMLNHVKNIGAFISEAKYKGTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQK 129
+ P K +S+A YK K ++ Y P I V A + S+ YK+
Sbjct: 1521 ELPQFIQAKVNALNMSDAHYKADWKKTIAKG-YDLRPDAIPIVAAKSSRNIASDCKYKEA 1579
Query: 130 HDAAKGFS-DYAHMKEPPEVKHAMEVNKHQSNISYRKDVQDTHT-YSAELDRPDIKMATQ 187
++ AKG + +++ P++ H M V K QS+ Y+K + + T Y LD + A +
Sbjct: 1580 YEKAKGKQVGFLSLQDDPKLVHYMNVAKIQSDREYKKGYEASKTKYHTPLDMVSVTAAKK 1639
Query: 188 ISKIISNAEYKKGQGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYN 247
++ +NA Y++ P + + EH+ A ++ S YK F N MK +
Sbjct: 1640 SQEVATNANYRQSYHHYTLLPDAL---NVEHSRNAMQIQSDNLYKSDFTNWMKG--IGWV 1694
Query: 248 PLESASFRQNQLAATLASNVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLS--GREYK 305
P+ES + + A + S KY++ + + + + ++ L S L+ R Y
Sbjct: 1695 PIESLEVEKAKKAGEILSEKKYRQHPEKLKFTYA----MDTMEQALNKSNKLNMDKRLYT 1750
Query: 306 KLFEENKGMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKE 365
+ + ++K H D + L + N + S YK +E+ K K + + +A++
Sbjct: 1751 EKWNKDKTTIHVMPDTPDILLSRVNQITMSDKLYKAGWEEEKKKGYDLRPDAIAIKAARA 1810
Query: 366 AQKMQSEKVYKEDFEKEIKGR--SSLDLDKTPEFLHVKYITNLLREKEYKKDLENE---- 419
++ + S+ YK+ +E + KG+ L+ P+ +H + + ++EYKK E
Sbjct: 1811 SRDIASDYKYKKAYE-QAKGKHIGFRSLEDDPKLVHFMQVAKMQSDREYKKGYEKSKTSF 1869
Query: 420 ------------IKGKGMELNS-------------EVLDIQRAKRASEMASEKEYKKDLE 454
K + + N+ + + + AK ++ S+ +YK D
Sbjct: 1870 HTPVDMLSVVAAKKSQEVATNANYRNVIHTYNMLPDAMSFELAKNMMQIQSDNQYKADYA 1929
Query: 455 SIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVST--DTLDVQRAK 512
+KG G +LE + KKA EI SEK Y++ +T ++ ST D++++ A+
Sbjct: 1930 DFMKGIGW-LPLGSLEAEKNKKAMEIISEKKYRQHPDT------LKYSTLMDSMNMVLAQ 1982
Query: 513 KASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYK---DEAEKMLS 569
+++ ++ YK+ E + K K + + DIP I+ AK + S + YK +E++K
Sbjct: 1983 NNAKIMNEHLYKQAWEAD-KTK-VHIMPDIPQIILAKANAINMSDKLYKLSLEESKK--K 2038
Query: 570 NYSTIADTPEIQRIKTTQQNISAVFYK--KEVGAGTAV-----KDSPEIERVKKNQQNIS 622
Y D I+ K ++ S YK E G G V +D P++ + + S
Sbjct: 2039 GYDLRPDAIPIKAAKASRDIASDYKYKYNYEKGKGKMVGFRSLEDDPKLVHSMQVAKMQS 2098
Query: 623 SVKYKEEIKHA-TAISDPPELKRV---KENQKNISNLQYKEQNYK------ATPVSMTPE 672
+YK+ ++ T+ P ++ V K+ Q NI+N YK +K A + +T
Sbjct: 2099 DREYKKNYENTKTSYHTPADMLSVTAAKDAQANITNTNYKHLIHKYILLPDAMNIELTRN 2158
Query: 673 IERVRRNQEQLSAVK--YKGELQRGTAISDPPELKRAKENQKNISNVYYRGQLGRATTLS 730
+ R++ + E YKG G + + E+++AK+ + S+ YR
Sbjct: 2159 MNRIQSDNEYKQDYNEWYKG---LGWSPAGSLEVEKAKKATEYASDQKYRQHPSNFQFKK 2215
Query: 731 VTPEMERV--KKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHED 788
+T M+ V K+N ++ YT D + K + ++ DTP + K+ Q S Y
Sbjct: 2216 LTDSMDMVLAKQNAHTMNKHLYTIDWNKDKTKIHVMPDTPDILQAKQNQTLYSQKLYKLG 2275
Query: 789 FEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYK-------GVHPHIVEMDRRPGIIVDL 841
+E+ +G+ VD + + + + SD YK G H + P +++ +
Sbjct: 2276 WEEALKKGYDLPVDAISVQLAKASRDIASDYKYKQGYRKQLGHHVGFRSLQDDPKLVLSM 2335
Query: 842 KV 843
V
Sbjct: 2336 NV 2337
Score = 182 bits (461), Expect = 2e-45
Identities = 213/874 (24%), Positives = 356/874 (40%), Gaps = 120/874 (13%)
Query: 50 SDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKYKGTIKADLSNSLYKRMPATI 109
S+++YKE + + KDK T V ++ + +N+ S YK + S Y +T+
Sbjct: 4665 SEVKYKENYHQIKDKYTTVLETVDYDRTRNLKNLYSSNLYKEAWDRVKATS-YILPSSTL 4723
Query: 110 DSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAH-MKEPPEVKHAMEVNKHQSNISYRK--- 165
A L S + Y+++++ K + + P + V K + YR
Sbjct: 4724 SLTHAKNQKHLASHIKYREEYEKFKALYTLPRSVDDDPNTARCLRVGKLNIDRLYRSVYE 4783
Query: 166 ----------------DVQDTHTYSAELD----------RPDIKMATQISKI---ISNAE 196
+D+ +E+D PD+++ + K+ IS+
Sbjct: 4784 KNKMKIHIVPDMVEMVTAKDSQKKVSEIDYRLRLHEWICHPDLQVNDHVRKVTDQISDIV 4843
Query: 197 YK------KGQGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLE 250
YK KG G V P+ HA A L IKYK +K + + +
Sbjct: 4844 YKDDLNWLKGIGCY-----VWDTPEILHAKHAYDLRDDIKYKAHM---LKTRNDYKLVTD 4895
Query: 251 SASFRQNQLAATLASNVKYKKD-IQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFE 309
+ + Q + S+ Y D + ++ V+ + LD L A K+ S YK
Sbjct: 4896 TPVYVQAVKSGKQLSDAVYHYDYVHSVRGKVAPTTKTVDLDRALHAYKLQSSNLYKTSLR 4955
Query: 310 ENKGMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNK------GKPMLEFV-------- 355
Y D H K + S KYKE YE K G + FV
Sbjct: 4956 TLPTGYRLPGDTPHFKHIKDTRYMSSYFKYKEAYEHTKAYGYTLGPKDVPFVHVRRVNNV 5015
Query: 356 ---------------------ETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKT 394
+TP + K+ Q+ SE +YK DF K ++G + L T
Sbjct: 5016 TSERLYRELYHKLKDKIHTTPDTPEIRQVKKTQEAVSELIYKSDFFK-MQGHM-ISLPYT 5073
Query: 395 PEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKKDLE 454
P+ +H +Y+ ++ + +YK+DL+ +KG G L + D+ R++ ++ S Y D
Sbjct: 5074 PQVIHCRYVGDITSDIKYKEDLQ-VLKGFGCFLY-DTPDMVRSRHLRKLWSNYLYT-DKA 5130
Query: 455 SIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVST-DTLDVQRAKK 513
++ K + DT E + ++ SE Y+ + K K + S DT D+ RAK+
Sbjct: 5131 RKMRDK-YKVVLDTPEYRKVQELKTHLSELVYRAAGK---KQKSIFTSVPDTPDLLRAKR 5186
Query: 514 ASEMASQKQYKK--DLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNY 571
++ SQ Y + E G Q + + AK ++ S++KYK + EKM Y
Sbjct: 5187 GQKLQSQYLYVELATKERPHHHAGNQTTA----LKHAKDVKDMVSEKKYKIQYEKMKDKY 5242
Query: 572 STIADTPEIQRIKTTQQNISAVFYK----KEVGAGTAVKDSPEIERVKKNQQNISSVKYK 627
+ + DTP + R K N S + YK K G VKD+ +I +K +IS +KYK
Sbjct: 5243 TPVPDTPILIRAKRAYWNASDLRYKETFQKTKGKYHTVKDALDIVYHRKVTDDISKIKYK 5302
Query: 628 EEIKHAT----AISDPPELKRVKENQKNISNLQYKEQNYKATPVSM----TPEIERVRRN 679
E +I D PE + +S+++YKE + TP+ +N
Sbjct: 5303 ENYMSQLGIWRSIPDRPEHFHHRAVTDTVSDVKYKEDLTWLKGIGCYAYDTPDFTLAEKN 5362
Query: 680 QEQLSAVKYKGELQRGTA----ISDPPELKRAKENQKNISNVYYRGQLGRATT----LSV 731
+ S KYK +R + ++D P + K + ++ YR + +
Sbjct: 5363 KTLYSKYKYKEVFERTKSDFKYVADSPINRHFKYATQLMNEKKYRADYEQRKDKYHLVVD 5422
Query: 732 TPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEK 791
P K + IS +KY +++++ K + + I+DTP + IS + Y ++ K
Sbjct: 5423 EPRHLLAKTAGDQISQIKYRKNYEKSKDKFTSIVDTPEHLRTTKVNKQISDILYKLEYNK 5482
Query: 792 TKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVH 825
K RG+T + D P+ VRK VSD YK V+
Sbjct: 5483 AKPRGYTTIHDTPMLLHVRKVKDEVSDLKYKEVY 5516
Score = 177 bits (448), Expect = 6e-44
Identities = 221/930 (23%), Positives = 393/930 (42%), Gaps = 147/930 (15%)
Query: 26 DQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFIS 85
D+ + V + + A+ T+ +SD+ YK + + K KC D+P + +S
Sbjct: 745 DKTKFTAVTDSPVLLQAQLNTKQLSDLNYKAKHEGEKFKCHIPADAPQFIQHRVNAYNLS 804
Query: 86 EAKYKGTIKADLSNSLYKRMPATIDSV---FAGEVTQLQSEVAYKQKHDAAKGFSDYA-H 141
+ YK D S K+ +D++ A T+ S+V YK+ ++ +KG A
Sbjct: 805 DNVYK----QDWEKSKAKKFDIKVDAIPLLAAKANTKNTSDVMYKKDYEKSKGKMIGALS 860
Query: 142 MKEPPEVKHAMEVNKHQSNISYRKDVQDT------------------------------- 170
+ + P++ H+++ K+QS+ YRKD + +
Sbjct: 861 INDDPKMLHSLKTAKNQSDREYRKDYEKSKTIYTAPLDMLQVTQAKKSQAIASDVDYKHI 920
Query: 171 -HTYSAELDRPDIKMATQISKIISNAEYKKGQGIMNKEPAVI--GRPDFEHAVEASKLSS 227
H+YS D ++ +A + + S+ EYK K + G + E A AS + +
Sbjct: 921 LHSYSYPPDSINVDLAKKAYALQSDVEYKADYNSWMKGCGWVPFGSLEMEKAKRASDILN 980
Query: 228 QIKYKEKFDN-----------------------------EMKDKKHHYN-PLESASFRQN 257
+ KY++ D + ++ H YN P + F Q
Sbjct: 981 EKKYRQHPDTLKFTSIEDAPITVQSKINQAQRSDIAYKAKGEEIIHKYNLPPDLPQFIQA 1040
Query: 258 QLAATLASNVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKML-SGREYKKLFEENKG-MY 315
++ A S YK D++++ DL KA++ S +YKK +E+ KG M
Sbjct: 1041 KVNAYNISENMYKADLKDLSKKGYDLRTDAIPIRAAKAARQAASDVQYKKDYEKAKGKMV 1100
Query: 316 HFDA--DAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETP----SYQASKEAQKM 369
F + D + +H+ A +QS +YK++YEK K K TP + A+K+AQ +
Sbjct: 1101 GFQSLQDDPKLVHYMNVAKIQSDREYKKDYEKTKSK-----YNTPHDMFNVVAAKKAQDV 1155
Query: 370 QSEKVYKEDFEKEIKGRSSLDLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNS 429
S YK ++DL+ + + ++ + YK+D N +KG G +
Sbjct: 1156 VSNVNYKHSLHHYTYLPDAMDLELSKNMMQIQ------SDNVYKEDYNNWMKGIGW-IPI 1208
Query: 430 EVLDIQRAKRASEMASEKEYKKDLESI-------------------------IKGKGMQA 464
LD+++ K+A + +EK+Y++ +++ K KG
Sbjct: 1209 GSLDVEKVKKAGDALNEKKYRQHPDTLKFTSIVDSPVMVQAKQNTKQVSDILYKAKGEDV 1268
Query: 465 ------GTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMA 518
D + AK A S+ YKRD ++ KG V D + + AK + +A
Sbjct: 1269 KHKYTMSPDLPQFLQAKCNAYNISDVCYKRDWH-DLIAKGNNVLGDAIPITAAKASRNIA 1327
Query: 519 SQKQYKKDLENEIKGK--GMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIAD 576
S +YK+ E KGK G + D P ++ +++ S R+YK E ++Y T D
Sbjct: 1328 SDYKYKEAYEKS-KGKHVGFRSLQDDPKLVHYMNVAKLQSDREYKKNYENTKTSYHTPGD 1386
Query: 577 TPEIQRIKTTQQNISAVFYKKEVGAGTAVKDSPEIERVKKNQQNISSVKYKEEI-KHATA 635
I K Q + V YK+ + T + D+ +E + Q S YK+E
Sbjct: 1387 MVSITAAKMAQDVATNVNYKQPLHHYTYLPDAMSLEHTRNVNQIQSDNVYKDEYNSFLKG 1446
Query: 636 ISDPP----ELKRVKENQKNISNLQYKE--QNYKATPVSMTPEIERVRRNQEQLSAVKYK 689
I P E+++VK+ ++ +Y++ K T V + + + N +QLS + YK
Sbjct: 1447 IGWIPIGSLEVEKVKKAGDALNERKYRQHPDTVKFTSVPDSMGMVLAQHNTKQLSDLNYK 1506
Query: 690 --GELQRGTAISDP--PELKRAKENQKNISNVYYRGQLGR--ATTLSVTPEMERV--KKN 741
GE + DP P+ +AK N N+S+ +Y+ + A + P+ + K+
Sbjct: 1507 VEGEKLKHKYTIDPELPQFIQAKVNALNMSDAHYKADWKKTIAKGYDLRPDAIPIVAAKS 1566
Query: 742 QENISS-VKYTQDHKQMKGRPSLIL---DTPAMRHVKEAQNHISMVKYHEDFEKTKGRGF 797
NI+S KY + +++ KG+ L D P + H S +Y + +E +K +
Sbjct: 1567 SRNIASDCKYKEAYEKAKGKQVGFLSLQDDPKLVHYMNVAKIQSDREYKKGYEASKTKYH 1626
Query: 798 TPVVDDPVTERVRKNTQVVSDAAYKGVHPH 827
TP+ VT +K+ +V ++A Y+ + H
Sbjct: 1627 TPLDMVSVT-AAKKSQEVATNANYRQSYHH 1655
Score = 176 bits (447), Expect = 8e-44
Identities = 208/828 (25%), Positives = 349/828 (42%), Gaps = 89/828 (10%)
Query: 30 YKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKY 89
+ PV + + A++ E++ DI+Y++++ +K K T +T++P+L+ + + + Y
Sbjct: 4156 FTPVDDRVDYVTAKQSGEILDDIKYRKDWNATKSKYT-LTETPLLHTAQEAARILDQYLY 4214
Query: 90 KGTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKG-FSDYAHMKEPPEV 148
K + + Y P + V A +QSE+ YK +H KG + M++ P++
Sbjct: 4215 KEGWERQKATG-YILPPDAVPFVHAHHCNDVQSELKYKAEHVKQKGHYVGVPTMRDDPKL 4273
Query: 149 KHAMEVNKHQSNISYRKDVQDTHT-YSAELDRPDIKMATQISKIISNAEYKKGQGIMNKE 207
+ Q+ Y++D T + D + A Q ++S+ +Y+ N
Sbjct: 4274 VWFEHAGQIQNERLYKEDYHKTKAKINIPADMVSVLAAKQGQTLVSDIDYR------NYL 4327
Query: 208 PAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNV 267
+ PD ++A K A L S+
Sbjct: 4328 HQWMCHPDQNDVIQARK-----------------------------------AYDLQSDN 4352
Query: 268 KYKKDIQNMHDPVSDLPNLLFLDHV--LKASKMLSGREYKKLFEENKGMYHFDADAVEHL 325
Y+ D++ + + +P L +DHV K +M+S +YKK EN + D E +
Sbjct: 4353 VYRADLEWLRG-IGWIP-LDSVDHVRVTKNQEMMSQIKYKKNALENYPNFRSVVDPPEIV 4410
Query: 326 HHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKG 385
K N+V QS VKYKE + K KGK +TP SK+ K+ S +YK +E
Sbjct: 4411 LAKINSVNQSDVKYKETFNKAKGKYTFS-PDTPHISHSKDMGKLYSTILYKGAWEGTKAY 4469
Query: 386 RSSLDLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVL----DIQRAKRAS 441
+LD P + K+ + E +YK+ E K KG L +V+ +
Sbjct: 4470 GYTLDERYIP-IVGAKHADLVNSELKYKETYE---KQKGHYLAGKVIGEFPGVVHCLDFQ 4525
Query: 442 EMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQV 501
+M S Y+K E + D + AK+ I S+ +Y+
Sbjct: 4526 KMRSALNYRKHYED--TKANVHIPNDMMNHVLAKRCQYILSDLEYRHYFHQ------WTS 4577
Query: 502 STDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYK 561
+ +V R + A E+ S YK DL N +KG G V D P IL AK++ ++ SQ +Y
Sbjct: 4578 LLEEPNVIRVRNAQEILSDNVYKDDL-NWLKGIGCYV-WDTPQILHAKKSYDLQSQLQYT 4635
Query: 562 DEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKKEV----GAGTAVKDSPEIERVKKN 617
++ L NY+ + DTP + N S V YK+ T V ++ + +R +
Sbjct: 4636 AAGKENLQNYNLVTDTPLYVTAVQSGINASEVKYKENYHQIKDKYTTVLETVDYDRTRNL 4695
Query: 618 QQNISSVKYKE---EIKHATAI--SDPPELKRVKENQKNISNLQYKE--QNYKA-----T 665
+ SS YKE +K + I S L K + S+++Y+E + +KA
Sbjct: 4696 KNLYSSNLYKEAWDRVKATSYILPSSTLSLTHAKNQKHLASHIKYREEYEKFKALYTLPR 4755
Query: 666 PVSMTPEIERVRR----NQEQLSAVKYKGELQRGTAISDPPELKRAKENQKNISNVYYRG 721
V P R R N ++L Y+ + + D E+ AK++QK +S + YR
Sbjct: 4756 SVDDDPNTARCLRVGKLNIDRLYRSVYEKNKMKIHIVPDMVEMVTAKDSQKKVSEIDYRL 4815
Query: 722 QLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHIS 781
+L + V+K + IS + Y D +KG + DTP + H K A +
Sbjct: 4816 RLHEWICHPDLQVNDHVRKVTDQISDIVYKDDLNWLKGIGCYVWDTPEILHAKHAYDLRD 4875
Query: 782 MVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIV 829
+KY KT+ + V D PV + K+ + +SDA Y + H V
Sbjct: 4876 DIKYKAHMLKTR-NDYKLVTDTPVYVQAVKSGKQLSDAVYHYDYVHSV 4922
Score = 175 bits (443), Expect = 2e-43
Identities = 208/901 (23%), Positives = 370/901 (41%), Gaps = 154/901 (17%)
Query: 36 DLSMELARKCTELISDIR-YKEEFKKSKDKCTFVTDSP--MLNHVKNIGAFISEAKYKGT 92
D + K +L D R Y E++ K K + D+P +L+ V I +S+ YK
Sbjct: 1730 DTMEQALNKSNKLNMDKRLYTEKWNKDKTTIHVMPDTPDILLSRVNQIT--MSDKLYKAG 1787
Query: 93 IKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKG-FSDYAHMKEPPEVKHA 151
+ + Y P I A + S+ YK+ ++ AKG + +++ P++ H
Sbjct: 1788 WEEEKKKG-YDLRPDAIAIKAARASRDIASDYKYKKAYEQAKGKHIGFRSLEDDPKLVHF 1846
Query: 152 MEVNKHQSNISYRKDVQDTHT-YSAELDRPDIKMATQISKIISNAEYKKGQGIMNKEPAV 210
M+V K QS+ Y+K + + T + +D + A + ++ +NA Y+ N P
Sbjct: 1847 MQVAKMQSDREYKKGYEKSKTSFHTPVDMLSVVAAKKSQEVATNANYRNVIHTYNMLPDA 1906
Query: 211 IGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYK 270
+ FE A ++ S +YK + + MK + PL S +N+ A + S KY+
Sbjct: 1907 MS---FELAKNMMQIQSDNQYKADYADFMKGIG--WLPLGSLEAEKNKKAMEIISEKKYR 1961
Query: 271 KDIQNM-HDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKG 329
+ + + + D N++ + +K+++ YK+ +E +K H D + + K
Sbjct: 1962 QHPDTLKYSTLMDSMNMVLAQN---NAKIMNEHLYKQAWEADKTKVHIMPDIPQIILAKA 2018
Query: 330 NAV------------------------------------LQSQVKYKEEYEKNKGKPM-- 351
NA+ + S KYK YEK KGK +
Sbjct: 2019 NAINMSDKLYKLSLEESKKKGYDLRPDAIPIKAAKASRDIASDYKYKYNYEKGKGKMVGF 2078
Query: 352 LEFVETPSYQASKEAQKMQSEKVYKEDFEK------------EIKGRSSLDLDKT----- 394
+ P S + KMQS++ YK+++E + + T
Sbjct: 2079 RSLEDDPKLVHSMQVAKMQSDREYKKNYENTKTSYHTPADMLSVTAAKDAQANITNTNYK 2138
Query: 395 ---------PEFLHVKYITNLLR---EKEYKKDLENEIKGKGMELNSEVLDIQRAKRASE 442
P+ ++++ N+ R + EYK+D KG G L++++AK+A+E
Sbjct: 2139 HLIHKYILLPDAMNIELTRNMNRIQSDNEYKQDYNEWYKGLGWSPAGS-LEVEKAKKATE 2197
Query: 443 MASEKEYK----------------------------KDLESIIKGKG---MQAGTDTLEM 471
AS+++Y+ K L +I K + DT ++
Sbjct: 2198 YASDQKYRQHPSNFQFKKLTDSMDMVLAKQNAHTMNKHLYTIDWNKDKTKIHVMPDTPDI 2257
Query: 472 QHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEI 531
AK+ + S+K YK E +K KG + D + VQ AK + ++AS +YK+ ++
Sbjct: 2258 LQAKQNQTLYSQKLYKLGWEEALK-KGYDLPVDAISVQLAKASRDIASDYKYKQGYRKQL 2316
Query: 532 KGK-GMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNI 590
G + D P ++ + +++ S+R+YK + EK + +S+ D + K Q+ +
Sbjct: 2317 GHHVGFRSLQDDPKLVLSMNVAKMQSEREYKKDFEKWKTKFSSPVDMLGVVLAKKCQELV 2376
Query: 591 SAVFYKKEVGAGTAVKDSPEIERVKKNQQNISSVKYKEEIKHATAISDPPELKRVKENQK 650
S V YK + T + D ++ + KK + S YK +++ I P
Sbjct: 2377 SDVDYKNYLHQWTCLPDQNDVVQAKKVYELQSENLYKSDLEWLRGIGWSP---------- 2426
Query: 651 NISNLQYKEQNYKATPVSMTPEIERVRRNQEQLSAVKYKGELQRG--TAISDPPELKRAK 708
+ +L E E+ +R E +S KY+ R T+I D ++ AK
Sbjct: 2427 -LGSL----------------EAEKNKRASEIISEKKYRQPPDRNKFTSIPDAMDIVLAK 2469
Query: 709 ENQKNISNVYYRGQLGRATT----LSVTPEMERVKKNQENISSVKYTQDHKQMKGRP-SL 763
N KN S+ YR + T + TP++ K N N S Y ++++K + L
Sbjct: 2470 TNAKNRSDRLYREAWDKDKTQIHIMPDTPDIVLAKANLINTSDKLYRMGYEELKRKGYDL 2529
Query: 764 ILDTPAMRHVKEAQNHISMVKYHEDFEKTKGR--GFTPVVDDPVTERVRKNTQVVSDAAY 821
+D ++ K ++ S KY E F K G G + DDP ++ SD Y
Sbjct: 2530 PVDAIPIKAAKASREIASEYKYKEGFRKQLGHHIGARNIEDDPKMMWSMHVAKIQSDREY 2589
Query: 822 K 822
K
Sbjct: 2590 K 2590
Score = 170 bits (431), Expect = 5e-42
Identities = 211/843 (25%), Positives = 359/843 (42%), Gaps = 114/843 (13%)
Query: 43 RKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKYKG-TIKADLSNSL 101
RK T+ ISDI YK++ K +V D+P + H K+ + KYK +K L
Sbjct: 4833 RKVTDQISDIVYKDDLNWLKGIGCYVWDTPEILHAKHAYDLRDDIKYKAHMLKTRNDYKL 4892
Query: 102 YKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMKEPPEVKHAMEVNKHQSNI 161
P + +V +G KQ DA + DY H
Sbjct: 4893 VTDTPVYVQAVKSG-----------KQLSDAVYHY-DYVH-------------------- 4920
Query: 162 SYRKDVQDTHTYSAELDRPDIKMATQISKIISNAEYKKGQGIMNKEPAVIG-RPDFEHAV 220
S R V T T + +LDR A K+ S+ YK + + G P F+H
Sbjct: 4921 SVRGKVAPT-TKTVDLDR-----ALHAYKLQSSNLYKTSLRTLPTGYRLPGDTPHFKHIK 4974
Query: 221 EASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYKKDIQNMHDPV 280
+ +SS KYKE +++ K + P + F + + S Y++ + D +
Sbjct: 4975 DTRYMSSYFKYKEAYEHT-KAYGYTLGP-KDVPFVHVRRVNNVTSERLYRELYHKLKDKI 5032
Query: 281 SDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQSQVKYK 340
P+ + V K + +S YK F + +G + +H + + S +KYK
Sbjct: 5033 HTTPDTPEIRQVKKTQEAVSELIYKSDFFKMQGHMISLPYTPQVIHCRYVGDITSDIKYK 5092
Query: 341 EEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPEFLHV 400
E+ + KG + +TP S+ +K+ S +Y D ++++ + + LD TPE+ V
Sbjct: 5093 EDLQVLKGFGCFLY-DTPDMVRSRHLRKLWSNYLYT-DKARKMRDKYKVVLD-TPEYRKV 5149
Query: 401 KYITNLLREKEYKKDLENEIKGKGMELN-SEVLDIQRAKRASEMASEKEYKKDLESIIKG 459
+ + L E Y+ + K K + + + D+ RAKR ++ S+ Y +E K
Sbjct: 5150 QELKTHLSELVYRAAGK---KQKSIFTSVPDTPDLLRAKRGQKLQSQYLY---VELATKE 5203
Query: 460 KGMQ-AGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMA 518
+ AG T ++HAK ++ SEK YK E ++K K V DT + RAK+A A
Sbjct: 5204 RPHHHAGNQTTALKHAKDVKDMVSEKKYKIQYE-KMKDKYTPVP-DTPILIRAKRAYWNA 5261
Query: 519 SQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTP 578
S +YK+ + + KGK V D DI+ ++ ++ S+ KYK+ L + +I D P
Sbjct: 5262 SDLRYKETFQ-KTKGKYHTVK-DALDIVYHRKVTDDISKIKYKENYMSQLGIWRSIPDRP 5319
Query: 579 EIQRIKTTQQNISAVFYKKEV----GAGTAVKDSPEIERVKKNQQNISSVKYKEEIKHAT 634
E + +S V YK+++ G G D+P+ +KN+ S KYKE +
Sbjct: 5320 EHFHHRAVTDTVSDVKYKEDLTWLKGIGCYAYDTPDFTLAEKNKTLYSKYKYKEVFERTK 5379
Query: 635 A----ISDPPELKRVKE-----NQKNISNLQYKEQNYKATPVSMTPEIERVRRNQEQLSA 685
+ ++D P + K N+K Y+++ K V P + +Q+S
Sbjct: 5380 SDFKYVADSPINRHFKYATQLMNEKKY-RADYEQRKDKYHLVVDEPRHLLAKTAGDQISQ 5438
Query: 686 VKYKGELQRG----TAISDPPELKRAKENQKNISNVYYRGQLGRA-----TTLSVTPEME 736
+KY+ ++ T+I D PE R + K IS++ Y+ + +A TT+ TP +
Sbjct: 5439 IKYRKNYEKSKDKFTSIVDTPEHLRTTKVNKQISDILYKLEYNKAKPRGYTTIHDTPMLL 5498
Query: 737 RVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEKTKGRG 796
V+K ++ +S +KY + +++ K ++ D ++ K+A + + Y + +E K
Sbjct: 5499 HVRKVKDEVSDLKYKEVYQRNKSNCTIEPDAVHIKAAKDAYKVNTNLDYKKQYEANKAHW 5558
Query: 797 -FTP---------------------------------VVDDPVTERVRKNTQVVSDAAYK 822
+TP V DD T +NT + SD YK
Sbjct: 5559 KWTPDRPDFLQAAKSSLQQSDFEYKLDREFLKGCKLSVTDDKNTVLALRNTLIESDLKYK 5618
Query: 823 GVH 825
H
Sbjct: 5619 EKH 5621
Score = 166 bits (420), Expect = 1e-40
Identities = 220/949 (23%), Positives = 388/949 (40%), Gaps = 133/949 (14%)
Query: 26 DQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFIS 85
D++ + V + L LA+ ++ Y E + K K + + D+P + + S
Sbjct: 3181 DKLKFTSVTDSLEQVLAKNNALNMNKRLYTEAWDKDKTQVHIMPDTPEIMLARQNKINYS 3240
Query: 86 EAKYKGTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAH-MKE 144
E+ Y+ ++ + Y I V A + S+ YK+ + G A + +
Sbjct: 3241 ESLYRQAME-EAKKEGYDLRSDAIPIVAAKASRDIASDYKYKEAYRKQLGHHIGARAVHD 3299
Query: 145 PPEVKHAMEVNKHQSNISYRKDVQDTHT-YSAELDRPDIKMATQISKIISNAEYKKGQGI 203
P++ ++ + K QS+ Y+KD + T YS+ +D I +A + ++S+ +YK
Sbjct: 3300 DPKIMWSLHIAKVQSDREYKKDFEKYKTRYSSPVDMLGIVLAKKCQTLVSDVDYKHP--- 3356
Query: 204 MNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATL 263
+++ + + D HA +A L S YK + K + P++S + + A L
Sbjct: 3357 LHEWICLPDQNDIIHARKAYDLQSDNLYKSDLEWM---KGIGWVPIDSLEVVRAKRAGEL 3413
Query: 264 ASNVKYKKDIQNMH-DPVSDLPN-LLFLDHVLKASKML---------------------- 299
S+ Y++ + + ++D P +L ++ L +K L
Sbjct: 3414 LSDTIYRQRPETLKFTSITDTPEQVLAKNNALNMNKRLYTEAWDNDKKTIHVMPDTPEIM 3473
Query: 300 ---------SGREYKKLFEENKGM-YHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGK 349
S + YK EE+K Y DA+ K + + S KYKE Y K G
Sbjct: 3474 LAKLNRINYSDKLYKLALEESKKEGYDLRLDAIPIQAAKASRDIASDYKYKEGYRKQLGH 3533
Query: 350 PM--LEFVETPSYQASKEAQKMQSEKVYKEDFEK-EIKGRSSLD---------------- 390
+ + P S K+QS++ YK++FEK + K S +D
Sbjct: 3534 HIGARNIKDDPKMMWSIHVAKIQSDREYKKEFEKWKTKFSSPVDMLGVVLAKKCQILVSD 3593
Query: 391 ------------LDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAK 438
L + + + +L + YK DLE ++G G V ++++ K
Sbjct: 3594 IDYKHPLHEWTCLPDQNDVIQARKAYDLQSDAIYKSDLE-WLRGIGWVPIGSV-EVEKVK 3651
Query: 439 RASEMASEKEYKK-----------DLESIIKGKG--------------------MQAGTD 467
RA E+ S+++Y++ D I+ K + D
Sbjct: 3652 RAGEILSDRKYRQPADQLKFTCITDTPEIVLAKNNALTMSKHLYTEAWDADKTSIHVMPD 3711
Query: 468 TLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDL 527
T ++ AK + S+K Y + + E K K + D + ++ AK + ++AS +YK+
Sbjct: 3712 TPDILLAKSNSANISQKLYTKGWD-ESKMKDYDLRADAISIKSAKASRDIASDYKYKEAY 3770
Query: 528 ENEIKGK--GMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKT 585
E + KG G Q D P I+ A +I S+R+YK E +K + +S+ D I K
Sbjct: 3771 EKQ-KGHHIGAQSIEDDPKIMCAIHAGKIQSEREYKKEFQKWKTKFSSPVDMLSILLAKK 3829
Query: 586 TQQNISAVFYKKEVGAGTAVKDSPEIERVKKNQQNISSVKYKEEIKHATAI----SDPPE 641
Q ++ + Y+ + T + D +I + KK S YK +++ I PE
Sbjct: 3830 CQTLVTDIDYRNYLHEWTCMPDQNDIIQAKKAYDLQSDALYKADLEWLRGIGWMPQGSPE 3889
Query: 642 LKRVKENQKNISNLQYKEQ--NYKATPVSMTPEIERVRRNQEQLSAVKYKGELQRGTA-- 697
+ RVK Q + Y+ N K T + TPE+ + N E +S KY+ +
Sbjct: 3890 VLRVKNAQNIFCDSVYRTPVVNLKYTSIVDTPEVVLAKSNAENISIPKYREVWDKDKTSI 3949
Query: 698 --ISDPPELKRAKENQKNISNVYYRG-----QLGRATTLSVTPEMERVKKNQENISSVKY 750
+ D PE+ A+ N N+SN YR + G L P ++ K ++E S KY
Sbjct: 3950 HIMPDTPEINLARANALNVSNKLYREGWDEMKAGCDVRLDAIP-IQAAKASREIASDYKY 4008
Query: 751 TQDHKQMKGRPSLIL---DTPAMRHVKEAQNHISMVKYHEDFEKTKGRGFTPVVDDPVTE 807
DH++ KG L D +R A + +Y D+ K K + +PV D ++
Sbjct: 4009 KLDHEKQKGHYVGTLTARDDNKIRWALIADKLQNEREYRLDWAKWKAKIQSPV--DMLSI 4066
Query: 808 RVRKNTQ-VVSDAAYKGVHPHIVEMDRRPGIIVDLKVWRTDPGSIFDLD 855
KN+Q +VSD Y+ M + +I K + +++ D
Sbjct: 4067 LHSKNSQALVSDMDYRNYLHQWTCMPDQNDVIQAKKAYELQSDNVYKAD 4115
Score = 165 bits (417), Expect = 2e-40
Identities = 193/735 (26%), Positives = 315/735 (42%), Gaps = 73/735 (9%)
Query: 116 EVTQLQSEVAYKQKHDAAKGFSDYAHMKEPPEVKHAMEVNKHQSNISYRKDVQDTHTYS- 174
++ L S YK+K + KG YA + PE++ +V S + YR D T
Sbjct: 91 KMQDLFSPNKYKEKFEKTKG-QPYASTTDTPELRRIKKVQDQLSEVKYRMDGDVAKTICH 149
Query: 175 AELDRPDIKMATQISKIISNAEYKKGQGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKEK 234
+ DI+ A ++S+ +S YK Q + + + PD V+A K ++ K
Sbjct: 150 VDEKAKDIEHAKKVSQQVSKVLYK--QNWEDTKDKYLLPPDAPELVQAVKNTAMFSKKLY 207
Query: 235 FDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYKKDI---QNMHDPVSDLPNLLFLDH 291
++ DK Y +S R+ A S+V YKK + Q P++D P++ F
Sbjct: 208 TEDWEADKSLFYPYNDSPELRRVAQAQKALSDVAYKKGLAEQQAQFTPLADPPDIEFAK- 266
Query: 292 VLKASKMLSGREYKKLFEEN-KGMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKP 350
K + +S ++YK+ +E KG + + E + + NA S KY+E++E K +
Sbjct: 267 --KVTNQVSKQKYKEDYENKIKGKWS-ETPCFEVANARMNADNISTRKYQEDFENMKDQI 323
Query: 351 MLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSS---LDLDKTPEFLHVKYITNLL 407
ETP Y+ +K+A S+ YKED+EK KG++ L + P+ +K + L
Sbjct: 324 YFMQTETPEYKMNKKAGVAASKVKYKEDYEKN-KGKADYNVLPASENPQLRQLKAAGDAL 382
Query: 408 REKEYKKDLENEIKGKGMELN-SEVLDIQRAKRASEMASEKEYKKDLESIIKGKGMQAGT 466
+K YK EN K K +N E + +S+K+YK I G + +
Sbjct: 383 SDKLYK---ENYEKTKAKSINYCETPKFKLDTVLQNFSSDKKYKDSYLKDILGHYVGSFE 439
Query: 467 DTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKD 526
D H K S+K+YK + E E +GKG T T + + KK + YK
Sbjct: 440 DPYH-SHCMKVTAQNSDKNYKAEYE-EDRGKGFFPQTITQEYEAIKKL-DQCKDHTYKVH 496
Query: 527 LENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTT 586
+ K K QV+ D P +L+A+ S+ S YK + E DTP + K
Sbjct: 497 PD---KTKFTQVT-DSPVLLQAQVNSKQLSDLNYKAKHESEKFKCHIPPDTPAFIQHKVN 552
Query: 587 QQNISAVFYKKEVGAGTAVKDSPEIERV-----KKNQQNISSVKYKEEIKH-------AT 634
N+S YK++ A K +++ + K N +N S V YK++ +
Sbjct: 553 AYNLSDNLYKQDWEKSKAKKFDIKVDAIPLLAAKANTKNTSDVMYKKDYEKNKGKMIGVL 612
Query: 635 AISDPPELKRVKENQKNISNLQYKEQNYKATPVSMTPEIERVRRNQEQLSAVKYKGELQR 694
+I+D P++ + KN S+ YKE NY+ T ++ KY+ + Q
Sbjct: 613 SINDDPKMLHSLKVAKNQSDRLYKE-NYEKTKA----------KSMNYCETPKYQLDTQ- 660
Query: 695 GTAISDPPELKRAKENQKNISNVYYRGQLGRATTLSVTPEMERVKKNQENISSVKYTQDH 754
LK E ++Y + LG P K S Y ++
Sbjct: 661 ---------LKNFSE--ARYKDLYVKDVLGHYVGSMEDPYHTHCMKVAAQNSDKSYKAEY 709
Query: 755 KQMKGR----PSLILDTPAMRHVKEAQNHISMVKYHEDFEKTKGRGFTPVVDDPVTERVR 810
++ KG+ ++ + A++ + + ++H K H D KTK FT V D PV + +
Sbjct: 710 EEDKGKCYFPQTITQEYEAIKKLDQCKDH--TYKVHPD--KTK---FTAVTDSPVLLQAQ 762
Query: 811 KNTQVVSDAAYKGVH 825
NT+ +SD YK H
Sbjct: 763 LNTKQLSDLNYKAKH 777
Score = 165 bits (417), Expect = 2e-40
Identities = 215/851 (25%), Positives = 357/851 (41%), Gaps = 67/851 (7%)
Query: 11 DETEEEKIGEE-ENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTF-- 67
D K E+ EN +DQ+++ E ++ +K S ++YKE+++K+K K +
Sbjct: 305 DNISTRKYQEDFENMKDQIYFMQT-ETPEYKMNKKAGVAASKVKYKEDYEKNKGKADYNV 363
Query: 68 --VTDSPMLNHVKNIGAFISEAKYKGTIKADLSNSL-YKRMPA-TIDSVFAGEVTQLQSE 123
+++P L +K G +S+ YK + + S+ Y P +D+V + S+
Sbjct: 364 LPASENPQLRQLKAAGDALSDKLYKENYEKTKAKSINYCETPKFKLDTV----LQNFSSD 419
Query: 124 VAYKQKHDAAKGFSDYAHMKEPPEVKHAMEVNKHQSNISYRKDVQD-------THTYSAE 176
YK + Y E P H M+V S+ +Y+ + ++ T + E
Sbjct: 420 KKYKDSY-LKDILGHYVGSFEDPYHSHCMKVTAQNSDKNYKAEYEEDRGKGFFPQTITQE 478
Query: 177 LDRPDIKMATQISKIISNAEYKKGQGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFD 236
+ IK Q K K V P A SK S + YK K +
Sbjct: 479 YEA--IKKLDQCKDHTYKVHPDK-----TKFTQVTDSPVLLQAQVNSKQLSDLNYKAKHE 531
Query: 237 NEMKDKKHHYNPLESASFRQNQLAATLASNVKYKKDIQNMHDPVSDLP-NLLFLDHVLKA 295
+E K K H P ++ +F Q+++ A S+ YK+D + D+ + + L
Sbjct: 532 SE-KFKCH--IPPDTPAFIQHKVNAYNLSDNLYKQDWEKSKAKKFDIKVDAIPLLAAKAN 588
Query: 296 SKMLSGREYKKLFEENKGM---YHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPML 352
+K S YKK +E+NKG D + LH A QS YKE YEK K K M
Sbjct: 589 TKNTSDVMYKKDYEKNKGKMIGVLSINDDPKMLHSLKVAKNQSDRLYKENYEKTKAKSM- 647
Query: 353 EFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPEFLHVKYITNLLREKEY 412
+ ETP YQ + + SE YK+ + K++ G ++ P H + +K Y
Sbjct: 648 NYCETPKYQLDTQLKNF-SEARYKDLYVKDVLGHYVGSME-DPYHTHCMKVAAQNSDKSY 705
Query: 413 KKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQ 472
K + E E KGK + + + K+ + + YK + A TD+ +
Sbjct: 706 KAEYE-EDKGKCYFPQTITQEYEAIKKL-DQCKDHTYKVHPDK----TKFTAVTDSPVLL 759
Query: 473 HAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIK 532
A+ + S+ +YK E E K K + D + + + S YK+D E K
Sbjct: 760 QAQLNTKQLSDLNYKAKHEGE-KFK-CHIPADAPQFIQHRVNAYNLSDNVYKQDWEKS-K 816
Query: 533 GKGMQVSMDIPDILRA----KRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQ 588
K + +D +L A K TS++ ++ Y+ KM+ S D + +KT +
Sbjct: 817 AKKFDIKVDAIPLLAAKANTKNTSDVMYKKDYEKSKGKMIGALSINDDPKMLHSLKTAKN 876
Query: 589 NISAVF---YKKEVGAGTAVKDSPEIERVKKNQQNISSVKYKEEIKHATAISDPPELKRV 645
+ Y+K TA D ++ + KK+Q S V YK + + D +
Sbjct: 877 QSDREYRKDYEKSKTIYTAPLDMLQVTQAKKSQAIASDVDYKHILHSYSYPPDSINVDLA 936
Query: 646 KENQKNISNLQYK-EQNYKATPVSMTP----EIERVRRNQEQLSAVKYK--GELQRGTAI 698
K+ S+++YK + N P E+E+ +R + L+ KY+ + + T+I
Sbjct: 937 KKAYALQSDVEYKADYNSWMKGCGWVPFGSLEMEKAKRASDILNEKKYRQHPDTLKFTSI 996
Query: 699 SDPPELKRAKENQKNISNVYYRGQ----LGRATTLSVTPEMERVKKNQENISSVKYTQDH 754
D P ++K NQ S++ Y+ + + + P+ + K N NIS Y D
Sbjct: 997 EDAPITVQSKINQAQRSDIAYKAKGEEIIHKYNLPPDLPQFIQAKVNAYNISENMYKADL 1056
Query: 755 KQM-KGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEKTKGR--GFTPVVDDPVTERVRK 811
K + K L D +R K A+ S V+Y +D+EK KG+ GF + DDP
Sbjct: 1057 KDLSKKGYDLRTDAIPIRAAKAARQAASDVQYKKDYEKAKGKMVGFQSLQDDPKLVHYMN 1116
Query: 812 NTQVVSDAAYK 822
++ SD YK
Sbjct: 1117 VAKIQSDREYK 1127
Score = 163 bits (412), Expect = 9e-40
Identities = 215/936 (22%), Positives = 386/936 (41%), Gaps = 137/936 (14%)
Query: 10 KDETEEEKIGEEENEE--DQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTF 67
K++ E I E++ + D + Y +++ ++M LA+ +++++ YK+ ++ K K
Sbjct: 1947 KNKKAMEIISEKKYRQHPDTLKYSTLMDSMNMVLAQNNAKIMNEHLYKQAWEADKTKVHI 2006
Query: 68 VTDSPMLNHVKNIGAFISEAKYKGTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYK 127
+ D P + K +S+ YK +++ Y P I A + S+ YK
Sbjct: 2007 MPDIPQIILAKANAINMSDKLYKLSLEESKKKG-YDLRPDAIPIKAAKASRDIASDYKYK 2065
Query: 128 QKHDAAKG-FSDYAHMKEPPEVKHAMEVNKHQSNISYRKDVQDTHT-YSAELDRPDIKMA 185
++ KG + +++ P++ H+M+V K QS+ Y+K+ ++T T Y D + A
Sbjct: 2066 YNYEKGKGKMVGFRSLEDDPKLVHSMQVAKMQSDREYKKNYENTKTSYHTPADMLSVTAA 2125
Query: 186 TQISKIISNAEYKKGQGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHH 245
I+N YK +++K + + E +++ S +YK+ ++ K
Sbjct: 2126 KDAQANITNTNYKH---LIHKYILLPDAMNIELTRNMNRIQSDNEYKQDYNEWYKGLG-- 2180
Query: 246 YNPLESASFRQNQLAATLASNVKYKKDI------------------QNMHDP-------- 279
++P S + + A AS+ KY++ QN H
Sbjct: 2181 WSPAGSLEVEKAKKATEYASDQKYRQHPSNFQFKKLTDSMDMVLAKQNAHTMNKHLYTID 2240
Query: 280 ----------VSDLPNLLFLDHVLKASKMLSGREYKKLFEEN-KGMYHFDADAVEHLHHK 328
+ D P++L + + S + YK +EE K Y DA+ K
Sbjct: 2241 WNKDKTKIHVMPDTPDIL---QAKQNQTLYSQKLYKLGWEEALKKGYDLPVDAISVQLAK 2297
Query: 329 GNAVLQSQVKYKEEYEKNKGKPM--LEFVETPSYQASKEAQKMQSEKVYKEDFEK-EIKG 385
+ + S KYK+ Y K G + + P S KMQSE+ YK+DFEK + K
Sbjct: 2298 ASRDIASDYKYKQGYRKQLGHHVGFRSLQDDPKLVLSMNVAKMQSEREYKKDFEKWKTKF 2357
Query: 386 RSSLDL------DKTPE---------FLH-------------VKYITNLLREKEYKKDLE 417
S +D+ K E +LH K + L E YK DLE
Sbjct: 2358 SSPVDMLGVVLAKKCQELVSDVDYKNYLHQWTCLPDQNDVVQAKKVYELQSENLYKSDLE 2417
Query: 418 NEIKGKGME-LNSEVLDIQRAKRASEMASEKEYKK-----------DLESIIKGKG---- 461
++G G L S L+ ++ KRASE+ SEK+Y++ D I+ K
Sbjct: 2418 -WLRGIGWSPLGS--LEAEKNKRASEIISEKKYRQPPDRNKFTSIPDAMDIVLAKTNAKN 2474
Query: 462 ----------------MQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDT 505
+ DT ++ AK S+K Y+ E E+K KG + D
Sbjct: 2475 RSDRLYREAWDKDKTQIHIMPDTPDIVLAKANLINTSDKLYRMGYE-ELKRKGYDLPVDA 2533
Query: 506 LDVQRAKKASEMASQKQYKKDLENEIKGK-GMQVSMDIPDILRAKRTSEIYSQRKYKDEA 564
+ ++ AK + E+AS+ +YK+ ++ G + D P ++ + ++I S R+YK +
Sbjct: 2534 IPIKAAKASREIASEYKYKEGFRKQLGHHIGARNIEDDPKMMWSMHVAKIQSDREYKKDF 2593
Query: 565 EKMLSNYSTIADTPEIQRIKTTQQNISAVFYKKEVGAGTAVKDSPEIERVKKNQQNISSV 624
EK + +S+ D + K Q +S V YK + T + D ++ ++ S
Sbjct: 2594 EKWKTKFSSPVDMLGVVLAKKCQTLVSDVDYKNYLHQWTCLPDQSDVIHARQAYDLQSDN 2653
Query: 625 KYKEEIKHATAI----SDPPELKRVKENQKNISNLQYKE--QNYKATPVSMTPEIERVRR 678
YK +++ I S E ++ K + +S+ Y++ +K + + + + +
Sbjct: 2654 LYKSDLQWLKGIGWMTSGSLEDEKNKRATQILSDHVYRQHPDQFKFSSLMDSIPMVLAKN 2713
Query: 679 NQEQLSAVKYKGELQRGTA----ISDPPELKRAKENQKNISNVYYRGQLGRATTLSVTPE 734
N ++ Y + + D PE+ AK+N+ N S Y+ L A
Sbjct: 2714 NAITMNHRLYTEAWDKDKTTVHIMPDTPEVLLAKQNKVNYSEKLYKLGLEEAKRKGYDMR 2773
Query: 735 MERV-----KKNQENISSVKYTQDHKQMKGR---PSLILDTPAMRHVKEAQNHISMVKYH 786
++ + K +++ S KY + +++ G I D P M S +Y
Sbjct: 2774 VDAIPIKAAKASRDIASEFKYKEGYRKQLGHHIGARAIRDDPKMMWSMHVAKIQSDREYK 2833
Query: 787 EDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYK 822
+DFEK K + F+ VD +K +VSD YK
Sbjct: 2834 KDFEKWKTK-FSSPVDMLGVVLAKKCQTLVSDVDYK 2868
Score = 155 bits (392), Expect = 2e-37
Identities = 170/699 (24%), Positives = 307/699 (43%), Gaps = 57/699 (8%)
Query: 157 HQSNISYRKDVQDTHTYSAELDRPDIKMATQISKIISNAEYKKGQGIMNKEPAVIGRPDF 216
+++ + D + + T L +P + + +K +P+ P
Sbjct: 32 YETTTTRTSDYEQSETSKPALAQPALAQPASAKPVERRKVIRK-----KVDPSKFMTPYI 86
Query: 217 EHAVEASKLSSQIKYKEKFDNEMKDKKHHY-NPLESASFRQNQLAATLASNVKYKKD--- 272
H+ + L S KYKEKF+ K K Y + ++ R+ + S VKY+ D
Sbjct: 87 AHSQKMQDLFSPNKYKEKFE---KTKGQPYASTTDTPELRRIKKVQDQLSEVKYRMDGDV 143
Query: 273 ---IQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKG 329
I ++ + D ++H K S+ +S YK+ +E+ K Y DA E +
Sbjct: 144 AKTICHVDEKAKD------IEHAKKVSQQVSKVLYKQNWEDTKDKYLLPPDAPELVQAVK 197
Query: 330 NAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSL 389
N + S+ Y E++E +K + ++P + +AQK S+ YK+ ++
Sbjct: 198 NTAMFSKKLYTEDWEADKSL-FYPYNDSPELRRVAQAQKALSDVAYKKGLAEQ--QAQFT 254
Query: 390 DLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEY 449
L P+ K +TN + +++YK+D EN+IKGK E + ++ A+ ++ S ++Y
Sbjct: 255 PLADPPDIEFAKKVTNQVSKQKYKEDYENKIKGKWSE--TPCFEVANARMNADNISTRKY 312
Query: 450 KKDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGK---GMQVSTDTL 506
++D E+ +K + T+T E + KKA AS+ YK D E KGK + +++
Sbjct: 313 QEDFEN-MKDQIYFMQTETPEYKMNKKAGVAASKVKYKEDYEKN-KGKADYNVLPASENP 370
Query: 507 DVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEK 566
+++ K A + S K YK++ E + K K + + P S +KYKD K
Sbjct: 371 QLRQLKAAGDALSDKLYKENYE-KTKAKSINY-CETPKFKLDTVLQNFSSDKKYKDSYLK 428
Query: 567 -MLSNY-STIADTPEIQRIKTTQQNISAVF---YKKEVGAGTAVKD-SPEIERVKK-NQQ 619
+L +Y + D +K T QN + Y+++ G G + + E E +KK +Q
Sbjct: 429 DILGHYVGSFEDPYHSHCMKVTAQNSDKNYKAEYEEDRGKGFFPQTITQEYEAIKKLDQC 488
Query: 620 NISSVKYKEEIKHATAISDPPELKRVKENQKNISNLQYK----EQNYKATPVSMTPEIER 675
+ K + T ++D P L + + N K +S+L YK + +K TP +
Sbjct: 489 KDHTYKVHPDKTKFTQVTDSPVLLQAQVNSKQLSDLNYKAKHESEKFKCHIPPDTPAFIQ 548
Query: 676 VRRNQEQLSAVKYKGELQRGTAIS-----DPPELKRAKENQKNISNVYY-------RGQL 723
+ N LS YK + ++ A D L AK N KN S+V Y +G++
Sbjct: 549 HKVNAYNLSDNLYKQDWEKSKAKKFDIKVDAIPLLAAKANTKNTSDVMYKKDYEKNKGKM 608
Query: 724 GRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHISMV 783
+++ P+M K +N S Y +++++ K + +TP + + +N S
Sbjct: 609 IGVLSINDDPKMLHSLKVAKNQSDRLYKENYEKTKAKSMNYCETPKYQLDTQLKN-FSEA 667
Query: 784 KYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYK 822
+Y + + K + ++DP K SD +YK
Sbjct: 668 RYKDLYVKDVLGHYVGSMEDPYHTHCMKVAAQNSDKSYK 706
Score = 153 bits (387), Expect = 7e-37
Identities = 205/877 (23%), Positives = 351/877 (40%), Gaps = 106/877 (12%)
Query: 16 EKIGEEENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLN 75
+K+ E+ E D+ + P + + + + +SD+ YK+ + + + T + D P +
Sbjct: 204 KKLYTEDWEADKSLFYPYNDSPELRRVAQAQKALSDVAYKKGLAEQQAQFTPLADPPDIE 263
Query: 76 HVKNIGAFISEAKYK---------------------GTIKAD-------------LSNSL 101
K + +S+ KYK + AD + + +
Sbjct: 264 FAKKVTNQVSKQKYKEDYENKIKGKWSETPCFEVANARMNADNISTRKYQEDFENMKDQI 323
Query: 102 YKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAHM--KEPPEVKHAMEVNKHQS 159
Y T + + S+V YK+ ++ KG +DY + E P+++ S
Sbjct: 324 YFMQTETPEYKMNKKAGVAASKVKYKEDYEKNKGKADYNVLPASENPQLRQLKAAGDALS 383
Query: 160 NISYRKDVQDTHTYSAE-LDRPDIKMATQISKIISNAEYKKG--QGIMNKEPAVIGRPDF 216
+ Y+++ + T S + P K+ T + S+ +YK + I+ P
Sbjct: 384 DKLYKENYEKTKAKSINYCETPKFKLDTVLQNFSSDKKYKDSYLKDILGHYVGSFEDPYH 443
Query: 217 EHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYKKDIQNM 276
H ++ + +S YK +++ E + K + +L K D +
Sbjct: 444 SHCMKVTAQNSDKNYKAEYE-EDRGKGFFPQTITQEYEAIKKLDQCKDHTYKVHPD-KTK 501
Query: 277 HDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQSQ 336
V+D P LL SK LS YK E K H D + HK NA S
Sbjct: 502 FTQVTDSPVLL---QAQVNSKQLSDLNYKAKHESEKFKCHIPPDTPAFIQHKVNAYNLSD 558
Query: 337 VKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGR--SSLDLDKT 394
YK+++EK+K K V+ A+K K S+ +YK+D+EK KG+ L ++
Sbjct: 559 NLYKQDWEKSKAKKFDIKVDAIPLLAAKANTKNTSDVMYKKDYEKN-KGKMIGVLSINDD 617
Query: 395 PEFLHVKYITNLLREKEYKKDLENEIKGKGM---ELNSEVLDIQRAKRASEMASEKEYKK 451
P+ LH + ++ YK++ E + K K M E LD Q K SE + Y K
Sbjct: 618 PKMLHSLKVAKNQSDRLYKENYE-KTKAKSMNYCETPKYQLDTQ-LKNFSEARYKDLYVK 675
Query: 452 DLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRA 511
D+ G M+ T H K A S+K YK + E E KGK T T + +
Sbjct: 676 DVLGHYVG-SMEDPYHT----HCMKVAAQNSDKSYKAEYE-EDKGKCYFPQTITQEYEAI 729
Query: 512 KKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNY 571
KK + YK + K K V+ D P +L+A+ ++ S YK + E
Sbjct: 730 KKL-DQCKDHTYKVHPD---KTKFTAVT-DSPVLLQAQLNTKQLSDLNYKAKHEGEKFKC 784
Query: 572 STIADTPEIQRIKTTQQNISAVFYKKEVGAGTAVKDSPEIERV-----KKNQQNISSVKY 626
AD P+ + + N+S YK++ A K +++ + K N +N S V Y
Sbjct: 785 HIPADAPQFIQHRVNAYNLSDNVYKQDWEKSKAKKFDIKVDAIPLLAAKANTKNTSDVMY 844
Query: 627 KEEIKH-------ATAISDPPELKRVKENQKNISNLQYKEQNYKATPVSMTPEIERVRRN 679
K++ + A +I+D P++ + KN S+ +Y++ K+ +
Sbjct: 845 KKDYEKSKGKMIGALSINDDPKMLHSLKTAKNQSDREYRKDYEKSKTIY----------- 893
Query: 680 QEQLSAVKYKGELQRGTAISDPPELKRAKENQKNISNVYYRGQLGRATTLSVTPEMERVK 739
TA D ++ +AK++Q S+V Y+ L + + ++ K
Sbjct: 894 ----------------TAPLDMLQVTQAKKSQAIASDVDYKHILHSYSYPPDSINVDLAK 937
Query: 740 KNQENISSVKYTQDHKQ-MKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEKTKGRGFT 798
K S V+Y D+ MKG + + M K A + ++ KY + + K FT
Sbjct: 938 KAYALQSDVEYKADYNSWMKGCGWVPFGSLEMEKAKRASDILNEKKYRQHPDTLK---FT 994
Query: 799 PVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRP 835
+ D P+T + + N SD AYK I+ P
Sbjct: 995 SIEDAPITVQSKINQAQRSDIAYKAKGEEIIHKYNLP 1031
Score = 148 bits (374), Expect = 2e-35
Identities = 202/907 (22%), Positives = 384/907 (42%), Gaps = 132/907 (14%)
Query: 12 ETEEEKIGEEENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEF------------- 58
+ + ++ +++ E+ + Y ++ L + LA+KC L+SD+ YK
Sbjct: 3311 KVQSDREYKKDFEKYKTRYSSPVDMLGIVLAKKCQTLVSDVDYKHPLHEWICLPDQNDII 3370
Query: 59 --KKSKDKCTFVTDSPMLNHVKNIGAF------ISEAKYKGTIKADLSNSLYKRMPATI- 109
+K+ D + L +K IG + AK G + LS+++Y++ P T+
Sbjct: 3371 HARKAYDLQSDNLYKSDLEWMKGIGWVPIDSLEVVRAKRAGEL---LSDTIYRQRPETLK 3427
Query: 110 --------DSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMKEPPEVKHAMEVNKHQSNI 161
+ V A ++ Y + D K M + PE+ A + S+
Sbjct: 3428 FTSITDTPEQVLAKNNALNMNKRLYTEAWDNDK--KTIHVMPDTPEIMLAKLNRINYSDK 3485
Query: 162 SYRKDVQDTHT--YSAELDRPDIKMATQISKIISNAEYKKGQ--------GIMNKEPAVI 211
Y+ ++++ Y LD I+ A I S+ +YK+G G N +
Sbjct: 3486 LYKLALEESKKEGYDLRLDAIPIQAAKASRDIASDYKYKEGYRKQLGHHIGARN----IK 3541
Query: 212 GRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYKK 271
P ++ +K+ S +YK++F+ K K +P++ + L S++ YK
Sbjct: 3542 DDPKMMWSIHVAKIQSDREYKKEFE---KWKTKFSSPVDMLGVVLAKKCQILVSDIDYKH 3598
Query: 272 DIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNA 331
+ + LP+ + KA + S YK E +G+ +VE K
Sbjct: 3599 PLHEW----TCLPDQNDVIQARKAYDLQSDAIYKSDLEWLRGIGWVPIGSVEVEKVKRAG 3654
Query: 332 VLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLD- 390
+ S KY++ ++ K +TP +K S+ +Y E ++ + ++S+
Sbjct: 3655 EILSDRKYRQPADQLK---FTCITDTPEIVLAKNNALTMSKHLYTEAWDAD---KTSIHV 3708
Query: 391 LDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYK 450
+ TP+ L K + + +K Y K + E K K +L ++ + I+ AK + ++AS+ +YK
Sbjct: 3709 MPDTPDILLAKSNSANISQKLYTKGWD-ESKMKDYDLRADAISIKSAKASRDIASDYKYK 3767
Query: 451 KDLESIIKGKGMQAGTDTLE----MQHAKKAAEIASEKDYKRDLE--------------- 491
+ E K KG G ++E + A A +I SE++YK++ +
Sbjct: 3768 EAYE---KQKGHHIGAQSIEDDPKIMCAIHAGKIQSEREYKKEFQKWKTKFSSPVDMLSI 3824
Query: 492 ----------TEIKGKGM----QVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQ 537
T+I + D D+ +AKKA ++ S YK DLE ++G G
Sbjct: 3825 LLAKKCQTLVTDIDYRNYLHEWTCMPDQNDIIQAKKAYDLQSDALYKADLE-WLRGIGW- 3882
Query: 538 VSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYK- 596
+ P++LR K I+ Y+ + Y++I DTPE+ K+ +NIS Y+
Sbjct: 3883 MPQGSPEVLRVKNAQNIFCDSVYRTPVVNL--KYTSIVDTPEVVLAKSNAENISIPKYRE 3940
Query: 597 ---KEVGAGTAVKDSPEIERVKKNQQNISSVKYKE---EIKHATAIS-DPPELKRVKENQ 649
K+ + + D+PEI + N N+S+ Y+E E+K + D ++ K ++
Sbjct: 3941 VWDKDKTSIHIMPDTPEINLARANALNVSNKLYREGWDEMKAGCDVRLDAIPIQAAKASR 4000
Query: 650 KNISNLQYKEQNYKA-------------TPVSMTPEIERVRRNQE-QLSAVKYKGELQRG 695
+ S+ +YK + K + ++++ +E +L K+K ++Q
Sbjct: 4001 EIASDYKYKLDHEKQKGHYVGTLTARDDNKIRWALIADKLQNEREYRLDWAKWKAKIQSP 4060
Query: 696 TAISDPPELKRAKENQKNISNVYYRGQLGRATTLSVTPEMERVKKNQENISSVKYTQDHK 755
D + +K +Q +S++ YR L + T + ++ + KK E S Y D +
Sbjct: 4061 V---DMLSILHSKNSQALVSDMDYRNYLHQWTCMPDQNDVIQAKKAYELQSDNVYKADLE 4117
Query: 756 QMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQV 815
++G + D+ ++ H K A + S KY E FTPV D +++ ++
Sbjct: 4118 WLRGIGWMPNDSVSVNHAKHAADIFSEKKYRTKIETL---NFTPVDDRVDYVTAKQSGEI 4174
Query: 816 VSDAAYK 822
+ D Y+
Sbjct: 4175 LDDIKYR 4181
Score = 147 bits (372), Expect = 4e-35
Identities = 198/856 (23%), Positives = 368/856 (42%), Gaps = 118/856 (13%)
Query: 30 YKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFV-TDSPMLNHVKNIGAFISEAK 88
Y + + +S+E R ++ SD YK+E+ ++ S + VK G ++E K
Sbjct: 1412 YTYLPDAMSLEHTRNVNQIQSDNVYKDEYNSFLKGIGWIPIGSLEVEKVKKAGDALNERK 1471
Query: 89 YK---GTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMKEP 145
Y+ T+K + +P ++ V A T+ S++ YK + + K Y E
Sbjct: 1472 YRQHPDTVK-------FTSVPDSMGMVLAQHNTKQLSDLNYKVEGEKLK--HKYTIDPEL 1522
Query: 146 PEVKHAMEVNKHQSNISYRKDVQDTHTYSAELDRPD---IKMATQISKIISNAEYK---- 198
P+ A + S+ Y+ D + T +L RPD I A I S+ +YK
Sbjct: 1523 PQFIQAKVNALNMSDAHYKADWKKTIAKGYDL-RPDAIPIVAAKSSRNIASDCKYKEAYE 1581
Query: 199 KGQGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQ 258
K +G ++ P H + +K+ S +YK+ ++ K ++ PL+ S +
Sbjct: 1582 KAKGKQVGFLSLQDDPKLVHYMNVAKIQSDREYKKGYE---ASKTKYHTPLDMVSVTAAK 1638
Query: 259 LAATLASNVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEE-NKGMYHF 317
+ +A+N Y++ + + LP+ L ++H A ++ S YK F KG+
Sbjct: 1639 KSQEVATNANYRQSYHH----YTLLPDALNVEHSRNAMQIQSDNLYKSDFTNWMKGIGWV 1694
Query: 318 DADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEK-VYK 376
+++E K + S+ KY++ EK K ++ +E QA ++ K+ +K +Y
Sbjct: 1695 PIESLEVEKAKKAGEILSEKKYRQHPEKLKFTYAMDTME----QALNKSNKLNMDKRLYT 1750
Query: 377 EDFEKEIKGRSSLD-LDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQ 435
E + K+ ++++ + TP+ L + + +K YK E E K KG +L + + I+
Sbjct: 1751 EKWNKD---KTTIHVMPDTPDILLSRVNQITMSDKLYKAGWEEE-KKKGYDLRPDAIAIK 1806
Query: 436 RAKRASEMASEKEYKKDLESIIKGK--GMQAGTDTLEMQHAKKAAEIASEKDYKRDLETE 493
A+ + ++AS+ +YKK E KGK G ++ D ++ H + A++ S+++YK+ E
Sbjct: 1807 AARASRDIASDYKYKKAYEQ-AKGKHIGFRSLEDDPKLVHFMQVAKMQSDREYKKGYEKS 1865
Query: 494 --------------IKGKGMQVST---------------DTLDVQRAKKASEMASQKQYK 524
K +V+T D + + AK ++ S QYK
Sbjct: 1866 KTSFHTPVDMLSVVAAKKSQEVATNANYRNVIHTYNMLPDAMSFELAKNMMQIQSDNQYK 1925
Query: 525 KDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIK 584
D + +KG G + + + + K+ EI S++KY+ + + YST+ D+ + +
Sbjct: 1926 ADYADFMKGIGW-LPLGSLEAEKNKKAMEIISEKKYRQHPDTL--KYSTLMDSMNMVLAQ 1982
Query: 585 TTQQNISAVFYKKEVGAGTA----VKDSPEIERVKKNQQNISSVKYKEEIKHATAIS--- 637
+ ++ YK+ A + D P+I K N N+S YK ++ +
Sbjct: 1983 NNAKIMNEHLYKQAWEADKTKVHIMPDIPQIILAKANAINMSDKLYKLSLEESKKKGYDL 2042
Query: 638 --DPPELKRVKENQKNISNLQYKEQNYKATPVSMTPEIERVRRNQEQLSAVKYKGELQRG 695
D +K K ++ S+ +YK NY+ K KG++
Sbjct: 2043 RPDAIPIKAAKASRDIASDYKYK-YNYE-----------------------KGKGKMVGF 2078
Query: 696 TAISDPPELKRAKENQKNISNVYYRGQLGRATTLSVTP----EMERVKKNQENISSVKYT 751
++ D P+L + + K S+ Y+ T TP + K Q NI++ Y
Sbjct: 2079 RSLEDDPKLVHSMQVAKMQSDREYKKNYENTKTSYHTPADMLSVTAAKDAQANITNTNY- 2137
Query: 752 QDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDF-EKTKGRGFTPVVDDPVTERVR 810
K + + L+ D + + S +Y +D+ E KG G++P V E+ +
Sbjct: 2138 ---KHLIHKYILLPDAMNIELTRNMNRIQSDNEYKQDYNEWYKGLGWSPAGSLEV-EKAK 2193
Query: 811 KNTQVVSDAAYKGVHP 826
K T+ SD Y+ HP
Sbjct: 2194 KATEYASDQKYR-QHP 2208
Score = 146 bits (368), Expect = 1e-34
Identities = 220/947 (23%), Positives = 389/947 (41%), Gaps = 148/947 (15%)
Query: 7 EDIKDETEEEKIGEE--ENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDK 64
ED K++ + + + DQ + +++ + M LA+ ++ Y E + K K
Sbjct: 2674 EDEKNKRATQILSDHVYRQHPDQFKFSSLMDSIPMVLAKNNAITMNHRLYTEAWDKDKTT 2733
Query: 65 CTFVTDSPMLNHVKNIGAFISEAKYKGTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEV 124
+ D+P + K SE YK ++ R+ A I A + SE
Sbjct: 2734 VHIMPDTPEVLLAKQNKVNYSEKLYKLGLEEAKRKGYDMRVDA-IPIKAAKASRDIASEF 2792
Query: 125 AYKQKHDAAKGFSDYAH-MKEPPEVKHAMEVNKHQSNISYRKDVQDTHT-YSAELDRPDI 182
YK+ + G A +++ P++ +M V K QS+ Y+KD + T +S+ +D +
Sbjct: 2793 KYKEGYRKQLGHHIGARAIRDDPKMMWSMHVAKIQSDREYKKDFEKWKTKFSSPVDMLGV 2852
Query: 183 KMATQISKIISNAEYKKGQGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKE--------- 233
+A + ++S+ +YK +++ + + D HA +A L S YK
Sbjct: 2853 VLAKKCQTLVSDVDYKN---YLHQWTCLPDQSDVIHARQAYDLQSDNMYKSDLQWMRGIG 2909
Query: 234 ------------KFDNEMKDKKHHYNPLESASFRQ--NQLAATLASN-----------VK 268
K E+ K + P + F + L LA N
Sbjct: 2910 WVSIGSLDVEKCKRATEILSDKIYRQPPDRFKFTSVTDSLEQVLAKNNALNMNKRLYTEA 2969
Query: 269 YKKDIQNMHDPVSDLPNLLFL-DHVLKASKMLSGREYKKLFEENKGM-YHFDADAVEHLH 326
+ KD +H + D P ++ + + S+ L YK EE K Y +DA+ +
Sbjct: 2970 WDKDKTQIHI-MPDTPEIMLARQNKINYSETL----YKLANEEAKKKGYDLRSDAIPIVA 3024
Query: 327 HKGNAVLQSQVKYKEEYEKNKGKPM--LEFVETPSYQASKEAQKMQSEKVYKEDFEK-EI 383
K + + S KYK+ Y K G + + P S K+QS++ YK+DFEK +
Sbjct: 3025 AKASRDVISDYKYKDGYRKQLGHHIGARNIEDDPKMMWSMHVAKIQSDREYKKDFEKWKT 3084
Query: 384 KGRSSLD----------------------------LDKTPEFLHVKYITNLLREKEYKKD 415
K S +D L + +H + +L + YK D
Sbjct: 3085 KFSSPVDMLGVVLAKKCQTLVSDVDYKNYLHEWTCLPDQNDVIHARQAYDLQSDNIYKSD 3144
Query: 416 LENEIKGKG-MELNSEVLDIQRAKRASEMASEKEYKK------------DLESII-KGKG 461
L+ ++G G + + S +D+ + KRA+E+ S+ Y++ LE ++ K
Sbjct: 3145 LQ-WLRGIGWVPIGS--MDVVKCKRAAEILSDNIYRQPPDKLKFTSVTDSLEQVLAKNNA 3201
Query: 462 MQAGT------------------DTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVST 503
+ DT E+ A++ SE Y++ +E E K +G + +
Sbjct: 3202 LNMNKRLYTEAWDKDKTQVHIMPDTPEIMLARQNKINYSESLYRQAME-EAKKEGYDLRS 3260
Query: 504 DTLDVQRAKKASEMASQKQYKKDLENEIKGK-GMQVSMDIPDILRAKRTSEIYSQRKYKD 562
D + + AK + ++AS +YK+ ++ G + D P I+ + +++ S R+YK
Sbjct: 3261 DAIPIVAAKASRDIASDYKYKEAYRKQLGHHIGARAVHDDPKIMWSLHIAKVQSDREYKK 3320
Query: 563 EAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKKEVGAGTAVKDSPEIERVKKNQQNIS 622
+ EK + YS+ D I K Q +S V YK + + D +I +K S
Sbjct: 3321 DFEKYKTRYSSPVDMLGIVLAKKCQTLVSDVDYKHPLHEWICLPDQNDIIHARKAYDLQS 3380
Query: 623 SVKYKEEIKHATAIS----DPPELKRVKENQKNISNLQYKE--QNYKATPVSMTPEIERV 676
YK +++ I D E+ R K + +S+ Y++ + K T ++ TPE
Sbjct: 3381 DNLYKSDLEWMKGIGWVPIDSLEVVRAKRAGELLSDTIYRQRPETLKFTSITDTPEQVLA 3440
Query: 677 RRN----QEQLSAVKYKGELQRGTAISDPPELKRAKENQKNISNVYYRGQL------GRA 726
+ N ++L + + + + D PE+ AK N+ N S+ Y+ L G
Sbjct: 3441 KNNALNMNKRLYTEAWDNDKKTIHVMPDTPEIMLAKLNRINYSDKLYKLALEESKKEGYD 3500
Query: 727 TTLSVTPEMERVKKNQENISSVKYTQDHKQMKGR---PSLILDTPAMR---HVKEAQNHI 780
L P ++ K +++ S KY + +++ G I D P M HV + Q
Sbjct: 3501 LRLDAIP-IQAAKASRDIASDYKYKEGYRKQLGHHIGARNIKDDPKMMWSIHVAKIQ--- 3556
Query: 781 SMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQV-VSDAAYKGVHP 826
S +Y ++FEK K + +PV D + + K Q+ VSD YK HP
Sbjct: 3557 SDREYKKEFEKWKTKFSSPV--DMLGVVLAKKCQILVSDIDYK--HP 3599
Score = 137 bits (346), Expect = 4e-32
Identities = 200/872 (22%), Positives = 370/872 (42%), Gaps = 98/872 (11%)
Query: 14 EEEKIGEEENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPM 73
+ E+ +++ E+ + + ++ L + LA+KC EL+SD+ YK + T + D
Sbjct: 2341 QSEREYKKDFEKWKTKFSSPVDMLGVVLAKKCQELVSDVDYKNYL----HQWTCLPDQND 2396
Query: 74 LNHVKNIGAFISEAKYK--------------GTIKAD--------LSNSLYKR------- 104
+ K + SE YK G+++A+ +S Y++
Sbjct: 2397 VVQAKKVYELQSENLYKSDLEWLRGIGWSPLGSLEAEKNKRASEIISEKKYRQPPDRNKF 2456
Query: 105 --MPATIDSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMKEPPEVKHAMEVNKHQSNIS 162
+P +D V A + +S+ Y++ D K + M + P++ A + S+
Sbjct: 2457 TSIPDAMDIVLAKTNAKNRSDRLYREAWDKDK--TQIHIMPDTPDIVLAKANLINTSDKL 2514
Query: 163 YRKDVQDTHT--YSAELDRPDIKMATQISKIISNAEYKKGQGIMNKEPAVIGRPDFEH-- 218
YR ++ Y +D IK A +I S EYK +G + IG + E
Sbjct: 2515 YRMGYEELKRKGYDLPVDAIPIKAAKASREIAS--EYKYKEGFRKQLGHHIGARNIEDDP 2572
Query: 219 ----AVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYKKDIQ 274
++ +K+ S +YK+ F+ K K +P++ + TL S+V YK +
Sbjct: 2573 KMMWSMHVAKIQSDREYKKDFE---KWKTKFSSPVDMLGVVLAKKCQTLVSDVDYKNYLH 2629
Query: 275 NMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQ 334
+ LP+ + H +A + S YK + KG+ + ++E +K +
Sbjct: 2630 QW----TCLPDQSDVIHARQAYDLQSDNLYKSDLQWLKGIGWMTSGSLEDEKNKRATQIL 2685
Query: 335 SQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLD-LDK 393
S Y++ ++ K +++ + P A A M + ++Y E ++K+ ++++ +
Sbjct: 2686 SDHVYRQHPDQFKFSSLMDSI--PMVLAKNNAITM-NHRLYTEAWDKD---KTTVHIMPD 2739
Query: 394 TPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKKDL 453
TPE L K EK YK LE E K KG ++ + + I+ AK + ++ASE +YK+
Sbjct: 2740 TPEVLLAKQNKVNYSEKLYKLGLE-EAKRKGYDMRVDAIPIKAAKASRDIASEFKYKEGY 2798
Query: 454 ESIIKGK-GMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAK 512
+ G +A D +M + A+I S+++YK+D E + K K D L V AK
Sbjct: 2799 RKQLGHHIGARAIRDDPKMMWSMHVAKIQSDREYKKDFE-KWKTK-FSSPVDMLGVVLAK 2856
Query: 513 KASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYS 572
K + S YK L D D++ A++ ++ S YK + + M
Sbjct: 2857 KCQTLVSDVDYKNYLHQ------WTCLPDQSDVIHARQAYDLQSDNMYKSDLQWMRGIGW 2910
Query: 573 TIADTPEIQRIKTTQQNISAVFYKK--EVGAGTAVKDSPEIERVKKNQQNISSVKYKEE- 629
+ ++++ K + +S Y++ + T+V DS E K N N++ Y E
Sbjct: 2911 VSIGSLDVEKCKRATEILSDKIYRQPPDRFKFTSVTDSLEQVLAKNNALNMNKRLYTEAW 2970
Query: 630 IKHATAI---SDPPELKRVKENQKNISNLQYKEQNYKATPV-----SMTPEIERVRRNQE 681
K T I D PE+ ++N+ N S YK N +A S I + +++
Sbjct: 2971 DKDKTQIHIMPDTPEIMLARQNKINYSETLYKLANEEAKKKGYDLRSDAIPIVAAKASRD 3030
Query: 682 QLSAVKYKGELQR-------GTAISDPPELKRAKENQKNISNVYYRGQLGRATTLSVTP- 733
+S KYK ++ I D P++ + K S+ Y+ + T +P
Sbjct: 3031 VISDYKYKDGYRKQLGHHIGARNIEDDPKMMWSMHVAKIQSDREYKKDFEKWKTKFSSPV 3090
Query: 734 ---EMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFE 790
+ KK Q +S V D+K + + D + H ++A + S Y D +
Sbjct: 3091 DMLGVVLAKKCQTLVSDV----DYKNYLHEWTCLPDQNDVIHARQAYDLQSDNIYKSDLQ 3146
Query: 791 KTKGRGFTPVVDDPVTERVRKNTQVVSDAAYK 822
+G G+ P+ V + ++ +++SD Y+
Sbjct: 3147 WLRGIGWVPIGSMDVV-KCKRAAEILSDNIYR 3177
>gi|47087157 nebulette non-muscle isoform [Homo sapiens]
Length = 270
Score = 201 bits (510), Expect = 4e-51
Identities = 96/100 (96%), Positives = 96/100 (96%)
Query: 915 RPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVS 974
RP APVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVS
Sbjct: 171 RPGIIVAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVS 230
Query: 975 FRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFVN 1014
FRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFVN
Sbjct: 231 FRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFVN 270
Score = 162 bits (410), Expect = 1e-39
Identities = 85/130 (65%), Positives = 99/130 (76%), Gaps = 3/130 (2%)
Query: 711 QKNISNVYYRGQLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRP-SLILDTPA 769
+K N +Y Q TT++ TPE R+K+ E S VKY +D ++ KGR S++ DTP
Sbjct: 49 KKPYCNAHYPKQ--SFTTVADTPENLRLKQQSELQSQVKYKRDFEESKGRGFSIVTDTPE 106
Query: 770 MRHVKEAQNHISMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIV 829
++ +K Q IS VKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIV
Sbjct: 107 LQRLKRTQEQISNVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIV 166
Query: 830 EMDRRPGIIV 839
EMDRRPGIIV
Sbjct: 167 EMDRRPGIIV 176
Score = 71.6 bits (174), Expect = 3e-12
Identities = 51/137 (37%), Positives = 68/137 (49%), Gaps = 8/137 (5%)
Query: 512 KKASEMASQKQYKKD--LENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLS 569
K A M + K Y+K + D P+ LR K+ SE+ SQ KYK + E+
Sbjct: 36 KMALNMNNYKGYEKKPYCNAHYPKQSFTTVADTPENLRLKQQSELQSQVKYKRDFEESKG 95
Query: 570 N-YSTIADTPEIQRIKTTQQNISAVFY----KKEVGAG-TAVKDSPEIERVKKNQQNISS 623
+S + DTPE+QR+K TQ+ IS V Y +K G G T V D P ERV+KN Q +S
Sbjct: 96 RGFSIVTDTPELQRLKRTQEQISNVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSD 155
Query: 624 VKYKEEIKHATAISDPP 640
YK H + P
Sbjct: 156 AAYKGVHPHIVEMDRRP 172
Score = 64.7 bits (156), Expect = 4e-10
Identities = 38/98 (38%), Positives = 56/98 (57%), Gaps = 10/98 (10%)
Query: 603 TAVKDSPEIERVKKNQQNISSVKYKEEIKHA-----TAISDPPELKRVKENQKNISNLQY 657
T V D+PE R+K+ + S VKYK + + + + ++D PEL+R+K Q+ ISN++Y
Sbjct: 63 TTVADTPENLRLKQQSELQSQVKYKRDFEESKGRGFSIVTDTPELQRLKRTQEQISNVKY 122
Query: 658 KEQNYKA-----TPVSMTPEIERVRRNQEQLSAVKYKG 690
E K TPV P ERVR+N + +S YKG
Sbjct: 123 HEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKG 160
Score = 63.5 bits (153), Expect = 9e-10
Identities = 35/95 (36%), Positives = 54/95 (56%), Gaps = 2/95 (2%)
Query: 467 DTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKD 526
DT E K+ +E+ S+ YKRD E E KG+G + TDT ++QR K+ E S +Y +D
Sbjct: 67 DTPENLRLKQQSELQSQVKYKRDFE-ESKGRGFSIVTDTPELQRLKRTQEQISNVKYHED 125
Query: 527 LENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYK 561
E + KG+G +D P R ++ +++ S YK
Sbjct: 126 FE-KTKGRGFTPVVDDPVTERVRKNTQVVSDAAYK 159
Score = 59.7 bits (143), Expect = 1e-08
Identities = 36/95 (37%), Positives = 50/95 (52%), Gaps = 1/95 (1%)
Query: 319 ADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKED 378
AD E+L K + LQSQVKYK ++E++KG+ +TP Q K Q+ S Y ED
Sbjct: 66 ADTPENLRLKQQSELQSQVKYKRDFEESKGRGFSIVTDTPELQRLKRTQEQISNVKYHED 125
Query: 379 FEKEIKGRSSLDLDKTPEFLHVKYITNLLREKEYK 413
FEK KGR + P V+ T ++ + YK
Sbjct: 126 FEK-TKGRGFTPVVDDPVTERVRKNTQVVSDAAYK 159
Score = 55.5 bits (132), Expect = 3e-07
Identities = 42/170 (24%), Positives = 80/170 (47%), Gaps = 29/170 (17%)
Query: 634 TAISDPPELKRVKENQKNISNLQYKEQNYKA-----TPVSMTPEIERVRRNQEQLSAVKY 688
T ++D PE R+K+ + S ++YK ++ + V+ TPE++R++R QEQ+S VKY
Sbjct: 63 TTVADTPENLRLKQQSELQSQVKYKRDFEESKGRGFSIVTDTPELQRLKRTQEQISNVKY 122
Query: 689 KGELQRG-----TAISDPPELKRAKENQKNISNVYYRG------QLGRATTLSVTPEMER 737
+ ++ T + D P +R ++N + +S+ Y+G ++ R + V P +
Sbjct: 123 HEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVAPVLPG 182
Query: 738 VKKNQENISSVKYTQDHKQMKG--RPSLILDTPAMRHVKEAQNHISMVKY 785
Y Q H Q G + + +M+H + + +M Y
Sbjct: 183 A-----------YQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDY 221
Score = 55.5 bits (132), Expect = 3e-07
Identities = 31/94 (32%), Positives = 50/94 (53%), Gaps = 2/94 (2%)
Query: 394 TPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKKDL 453
TPE L +K + L + +YK+D E E KG+G + ++ ++QR KR E S +Y +D
Sbjct: 68 TPENLRLKQQSELQSQVKYKRDFE-ESKGRGFSIVTDTPELQRLKRTQEQISNVKYHEDF 126
Query: 454 ESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYK 487
E KG+G D + +K ++ S+ YK
Sbjct: 127 EK-TKGRGFTPVVDDPVTERVRKNTQVVSDAAYK 159
Score = 54.7 bits (130), Expect = 4e-07
Identities = 32/89 (35%), Positives = 47/89 (52%), Gaps = 2/89 (2%)
Query: 436 RAKRASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIK 495
R K+ SE+ S+ +YK+D E KG+G TDT E+Q K+ E S Y D E + K
Sbjct: 73 RLKQQSELQSQVKYKRDFEES-KGRGFSIVTDTPELQRLKRTQEQISNVKYHEDFE-KTK 130
Query: 496 GKGMQVSTDTLDVQRAKKASEMASQKQYK 524
G+G D +R +K +++ S YK
Sbjct: 131 GRGFTPVVDDPVTERVRKNTQVVSDAAYK 159
Score = 47.0 bits (110), Expect = 9e-05
Identities = 38/172 (22%), Positives = 79/172 (45%), Gaps = 17/172 (9%)
Query: 89 YKGTIKADLSNSLYKRMPATI-----DSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMK 143
YKG K N+ Y + T +++ + ++LQS+V YK+ + +KG ++ +
Sbjct: 44 YKGYEKKPYCNAHYPKQSFTTVADTPENLRLKQQSELQSQVKYKRDFEESKG-RGFSIVT 102
Query: 144 EPPEVKHAMEVNKHQSNISYRKDVQDT--HTYSAELDRPDIKMATQISKIISNAEYKKGQ 201
+ PE++ + SN+ Y +D + T ++ +D P + + ++++S+A YK
Sbjct: 103 DTPELQRLKRTQEQISNVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYK--- 159
Query: 202 GI------MNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYN 247
G+ M++ P +I P A + S + + M+ +H N
Sbjct: 160 GVHPHIVEMDRRPGIIVAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPN 211
Score = 46.6 bits (109), Expect = 1e-04
Identities = 37/177 (20%), Positives = 74/177 (41%), Gaps = 24/177 (13%)
Query: 6 FEDIKDETEEEKIGEEENEEDQVFYKPVIEDLS------------MELARKCTELISDIR 53
F + D E ++ ++ + QV YK E+ ++ ++ E IS+++
Sbjct: 62 FTTVADTPENLRLKQQSELQSQVKYKRDFEESKGRGFSIVTDTPELQRLKRTQEQISNVK 121
Query: 54 YKEEFKKSKDK-CTFVTDSPMLNHVKNIGAFISEAKYKGTIKADLSNSLYKRMPATIDSV 112
Y E+F+K+K + T V D P+ V+ +S+A YKG + + +R + V
Sbjct: 122 YHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIV--EMDRRPGIIVAPV 179
Query: 113 FAGEVTQLQSEVAYKQKHDAAKGFSDYAHMKEPPEVKHAMEVNKHQSNISYRKDVQD 169
G AY+Q H G+ + ++H+ + +++ Y +D
Sbjct: 180 LPG---------AYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDED 227
Score = 45.1 bits (105), Expect = 3e-04
Identities = 36/114 (31%), Positives = 54/114 (47%), Gaps = 10/114 (8%)
Query: 270 KKDIQNMHDP------VSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGM-YHFDADAV 322
KK N H P V+D P L L + S++ S +YK+ FEE+KG + D
Sbjct: 49 KKPYCNAHYPKQSFTTVADTPENLRLK---QQSELQSQVKYKRDFEESKGRGFSIVTDTP 105
Query: 323 EHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYK 376
E K S VKY E++EK KG+ V+ P + ++ ++ S+ YK
Sbjct: 106 ELQRLKRTQEQISNVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYK 159
Score = 44.3 bits (103), Expect = 6e-04
Identities = 28/95 (29%), Positives = 48/95 (50%), Gaps = 2/95 (2%)
Query: 356 ETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPEFLHVKYITNLLREKEYKKD 415
+TP K+ ++QS+ YK DFE E KGR + TPE +K + +Y +D
Sbjct: 67 DTPENLRLKQQSELQSQVKYKRDFE-ESKGRGFSIVTDTPELQRLKRTQEQISNVKYHED 125
Query: 416 LENEIKGKGMELNSEVLDIQRAKRASEMASEKEYK 450
E + KG+G + +R ++ +++ S+ YK
Sbjct: 126 FE-KTKGRGFTPVVDDPVTERVRKNTQVVSDAAYK 159
>gi|46049092 nebulin-related anchoring protein isoform C [Homo
sapiens]
Length = 1695
Score = 194 bits (493), Expect = 4e-49
Identities = 198/822 (24%), Positives = 376/822 (45%), Gaps = 57/822 (6%)
Query: 26 DQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFIS 85
D++ Y V + + A+ + +S + Y+ +++K+K T D P L K S
Sbjct: 449 DKLKYSSVTDTPQIVQAKINAQQLSHVNYRADYEKNKLNYTLPQDVPQLVKAKTNAKLFS 508
Query: 86 EAKYKGTIKADLSNSLYKRMPATIDSVFAGEVT-QLQSEVAYKQKHDAAKGFSDYAHMKE 144
E KYK + ++ A S+ A + + +L S + YK++++ KG A
Sbjct: 509 EVKYKEGWEKTKGKGFEMKLDAM--SLLAAKASGELASNIKYKEEYEKTKG---KAMGTA 563
Query: 145 PPEVKHAMEVNKHQSNISYRKDVQDTHT-YSAELDRPDIKMATQISKIISNAEYKKGQGI 203
+ H++++ K S + Y+K +++ T + +D +I+ A + + S+ +Y+K
Sbjct: 564 DSRLLHSLQIAKMSSEVEYKKGFEESKTRFHLPMDMVNIRHAKKAQTLASDLDYRKK--- 620
Query: 204 MNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATL 263
+++ + + A +A L S+++YK K + S + Q + A L
Sbjct: 621 LHEYTVLPEDMKTQWAKKAYGLQSELQYKADL---AWMKGVGWLTEGSLNLEQAKKAGQL 677
Query: 264 ASNVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVE 323
S Y++ + + + + + ++H K+ ++ SG YK E++ Y D
Sbjct: 678 VSEKNYRQRVDELK--FTSVTDSSQMEHAKKSQELQSGVAYKAGNEQSVHQYTISKDEPL 735
Query: 324 HLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEI 383
L + NA S+ YK +E K K +++ ++ A+K + + SE YKED+E+
Sbjct: 736 FLQARANAANLSEKLYKSSWENQKAKGFELRLDSLTFLAAKAKRDLASEVKYKEDYERS- 794
Query: 384 KGR--SSLDLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRAS 441
+G+ + D+ + H ++ L E EYKK E+ ++ +++ + A++A
Sbjct: 795 RGKLIGAKDVQGDSQMSHSLQMSKLQSELEYKKGFED--TKSQCHVSLDMVHLVHARKAQ 852
Query: 442 EMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQV 501
+A++ YK A ++++ AKKA + S+ Y+ D++ +KG G V
Sbjct: 853 HLATDVGYK------TAEHHFTALPTDMKVEWAKKAYGLQSDNQYRADVKW-MKGMGW-V 904
Query: 502 STDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYK 561
+T +L+V++AKKA E+ S+K+Y++ + +K ++ D P++++A+ + R Y+
Sbjct: 905 ATGSLNVEQAKKAGELISEKKYRQH-PDALKFTSIK---DTPEMVQARISYTQAVDRLYR 960
Query: 562 DEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKK-----EVGAGTAVKDSPEIERVKK 616
++ E + +Y+ AD PE+ K NIS YK+ G D+ + K
Sbjct: 961 EQGENIKHHYTPTADLPEVLLAKLNAMNISETRYKESWSKLRDGGYKLRLDALPFQAAKA 1020
Query: 617 NQQNISSVKYKE-------EIKHATAISDPPELKRVKENQKNISNLQYKE--QNYKA--- 664
+ + IS KYKE ++ + ++ D L S++ YK+ ++ KA
Sbjct: 1021 SGEIISDYKYKEAFEKMKGQMLGSRSLEDDISLAHSVYATSLQSDVNYKKGFEHSKAQFH 1080
Query: 665 TPVSMTPEIERVRRNQEQLSAVKYKGELQRGTAISDPPELKRAKENQKNISNVYYRGQL- 723
P+ M + ++ Q S YK L + T++++ L AK+ K S YR L
Sbjct: 1081 LPLDMA-ALVHAKKAQTLASNQDYKHPLPQYTSLAEDLRLSCAKKAHKLQSENLYRSDLN 1139
Query: 724 ---GRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHI 780
G A + T E+E KK E IS KY Q K + + DTP + H K N I
Sbjct: 1140 FMRGVACVIPGTLEIEGRKKASELISESKYRQHPHSFK--YTAVTDTPNLLHAK-FSNQI 1196
Query: 781 SMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYK 822
+ + ++ + +T + P R + N +SDA YK
Sbjct: 1197 TNERLYKAAGEDARHEYTMTLGLPEFIRAKTNAANLSDARYK 1238
Score = 189 bits (480), Expect = 1e-47
Identities = 218/821 (26%), Positives = 357/821 (43%), Gaps = 103/821 (12%)
Query: 42 ARKCTELISDIRYKEEFKKSKDKCTF----VTDSPMLNHVKNIGAFISEAKYKGTIKADL 97
A+K EL SDI+Y+++F K K + D+ +L +++ +SE KYK + +
Sbjct: 322 AKKAHELASDIKYRQDFNKMKGAAHYHSLPAQDNLVLKQAQSVNKLVSENKYKENYQNHM 381
Query: 98 SNSLYKRMPATIDSVFAGEVTQLQSEVAYK--QKHDAAKGFSDYAHMKE-PPEVKHAMEV 154
Y+ + ++ A +V L S VAYK KHD DY + P + AM++
Sbjct: 382 -RGRYEGVGMDRRTLHAMKVGSLASNVAYKADYKHDIV----DYNYPATLTPSYQTAMKL 436
Query: 155 NKHQSNISYRKDVQDTHTYSAELDRPDIKM----ATQISKIISNAEYKKGQGIMNKEPAV 210
+ +YR+ + D YS+ D P I A Q+S + A+Y+K + V
Sbjct: 437 -VPLKDANYRQSI-DKLKYSSVTDTPQIVQAKINAQQLSHVNYRADYEKNKLNYTLPQDV 494
Query: 211 IGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYK 270
P A +KL S++KYKE + E K L++ S + + LASN+KYK
Sbjct: 495 ---PQLVKAKTNAKLFSEVKYKEGW--EKTKGKGFEMKLDAMSLLAAKASGELASNIKYK 549
Query: 271 KDIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKGN 330
++ + + L H L+ +KM S EYKK FEE+K +H D V H K
Sbjct: 550 EEYEKTKGKAMGTADSRLL-HSLQIAKMSSEVEYKKGFEESKTRFHLPMDMVNIRHAKKA 608
Query: 331 AVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLD 390
L S + Y+++ + P E Q +K+A +QSE YK D
Sbjct: 609 QTLASDLDYRKKLHEYTVLP-----EDMKTQWAKKAYGLQSELQYKADLA---------- 653
Query: 391 LDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYK 450
+KG G L L++++AK+A ++ SEK Y+
Sbjct: 654 ----------------------------WMKGVGW-LTEGSLNLEQAKKAGQLVSEKNYR 684
Query: 451 KDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQR 510
+ ++ + + TD+ +M+HAKK+ E+ S YK E + +S D +
Sbjct: 685 QRVDEL----KFTSVTDSSQMEHAKKSQELQSGVAYKAGNEQSV--HQYTISKDEPLFLQ 738
Query: 511 AKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAE----K 566
A+ + S+K YK EN+ K KG ++ +D L AK ++ S+ KYK++ E K
Sbjct: 739 ARANAANLSEKLYKSSWENQ-KAKGFELRLDSLTFLAAKAKRDLASEVKYKEDYERSRGK 797
Query: 567 MLSNYSTIADTPEIQRIKTTQQNISAVFYKK---EVGAGTAVK-DSPEIERVKKNQQNIS 622
++ D+ ++ ++ S + YKK + + V D + +K Q +
Sbjct: 798 LIGAKDVQGDSQMSHSLQMSKLQ-SELEYKKGFEDTKSQCHVSLDMVHLVHARKAQHLAT 856
Query: 623 SVKYKEEIKHATAISDPPELKRVKENQKNISNLQY-------KEQNYKATPVSMTPEIER 675
V YK H TA+ +++ K+ S+ QY K + AT + +E+
Sbjct: 857 DVGYKTAEHHFTALPTDMKVEWAKKAYGLQSDNQYRADVKWMKGMGWVATG---SLNVEQ 913
Query: 676 VRRNQEQLSAVKYK--GELQRGTAISDPPELKRAKENQKNISNVYYRGQ----LGRATTL 729
++ E +S KY+ + + T+I D PE+ +A+ + + YR Q T
Sbjct: 914 AKKAGELISEKKYRQHPDALKFTSIKDTPEMVQARISYTQAVDRLYREQGENIKHHYTPT 973
Query: 730 SVTPEMERVKKNQENISSVKYTQDHKQMK-GRPSLILDTPAMRHVKEAQNHISMVKYHED 788
+ PE+ K N NIS +Y + +++ G L LD + K + IS KY E
Sbjct: 974 ADLPEVLLAKLNAMNISETRYKESWSKLRDGGYKLRLDALPFQAAKASGEIISDYKYKEA 1033
Query: 789 FEKTKGR--GFTPVVDDPVTERVRKNTQVVSDAAYKGVHPH 827
FEK KG+ G + DD T + SD YK H
Sbjct: 1034 FEKMKGQMLGSRSLEDDISLAHSVYATSLQSDVNYKKGFEH 1074
Score = 187 bits (474), Expect = 6e-47
Identities = 223/888 (25%), Positives = 384/888 (43%), Gaps = 98/888 (11%)
Query: 3 VPVFEDIKDETEEEKIGEEENEE-DQVFYK---PVIEDLSMELARKCTELISDIRYKEEF 58
+P E ++ + +GEE E+ +Q K P + + + A+K +L S + YK
Sbjct: 138 LPDPEIVRMVEARKSLGEEYTEDYEQPRGKGSFPAMITPAYQRAKKANQLASQVEYKRGH 197
Query: 59 KKSKDKCTFVTDSPMLNHVKNIGAFISEAKYKGTIKADLSNSLYKRMPATIDSVF--AGE 116
+ + + V D+P L K S+ +Y + + PA I + A
Sbjct: 198 DERISRFSTVVDTPELLRSKAGAQLQSDVRYTEDYEQQRGKGSF---PAMITPAYQIAKR 254
Query: 117 VTQLQSEVAYKQKHD-----------AAKGF----------SDYAHMKE----------- 144
+L S+V Y Q++ A+G Y E
Sbjct: 255 ANELASDVRYHQQYQKEMRGMAGPAIGAEGILTRECADQYGQGYPEEYEEHRGKGSFPAM 314
Query: 145 -PPEVKHAMEVNKHQSNISYRKDVQDT------HTYSAELDRPDIKMATQISKIISNAEY 197
P ++A + ++ S+I YR+D H+ A+ D +K A ++K++S +Y
Sbjct: 315 ITPAYQNAKKAHELASDIKYRQDFNKMKGAAHYHSLPAQ-DNLVLKQAQSVNKLVSENKY 373
Query: 198 KKG-QGIMNKEPAVIGRPDFE-HAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFR 255
K+ Q M +G HA++ L+S + YK + +++ D ++Y + S+
Sbjct: 374 KENYQNHMRGRYEGVGMDRRTLHAMKVGSLASNVAYKADYKHDIVD--YNYPATLTPSY- 430
Query: 256 QNQLAATLASNVKYKKDIQNM-HDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGM 314
Q + + Y++ I + + V+D P ++ ++ LS Y+ +E+NK
Sbjct: 431 QTAMKLVPLKDANYRQSIDKLKYSSVTDTPQIV---QAKINAQQLSHVNYRADYEKNKLN 487
Query: 315 YHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKV 374
Y D + + K NA L S+VKYKE +EK KGK ++ S A+K + ++ S
Sbjct: 488 YTLPQDVPQLVKAKTNAKLFSEVKYKEGWEKTKGKGFEMKLDAMSLLAAKASGELASNIK 547
Query: 375 YKEDFEKEIKGRSSLDLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDI 434
YKE++EK KG++ D LH I + E EYKK E E K + L ++++I
Sbjct: 548 YKEEYEK-TKGKAMGTADS--RLLHSLQIAKMSSEVEYKKGFE-ESKTR-FHLPMDMVNI 602
Query: 435 QRAKRASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEI 494
+ AK+A +AS+ +Y+K L + ++ Q AKKA + SE YK DL +
Sbjct: 603 RHAKKAQTLASDLDYRKKLHE------YTVLPEDMKTQWAKKAYGLQSELQYKADL-AWM 655
Query: 495 KGKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEI 554
KG G ++ +L++++AKKA ++ S+K Y++ ++ E+K + D + AK++ E+
Sbjct: 656 KGVGW-LTEGSLNLEQAKKAGQLVSEKNYRQRVD-ELKFTSV---TDSSQMEHAKKSQEL 710
Query: 555 YSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYK----KEVGAGTAVK-DSP 609
S YK E+ + Y+ D P + + N+S YK + G ++ DS
Sbjct: 711 QSGVAYKAGNEQSVHQYTISKDEPLFLQARANAANLSEKLYKSSWENQKAKGFELRLDSL 770
Query: 610 EIERVKKNQQNISSVKYKEEIKH-------ATAISDPPELKRVKENQKNISNLQYK---E 659
K + S VKYKE+ + A + ++ + K S L+YK E
Sbjct: 771 TFLAAKAKRDLASEVKYKEDYERSRGKLIGAKDVQGDSQMSHSLQMSKLQSELEYKKGFE 830
Query: 660 QNYKATPVSM-TPEIERVRRNQEQLSAVKYKGELQRGTAISDPPELKRAKENQKNISNVY 718
VS+ + R+ Q + V YK TA+ +++ AK+ S+
Sbjct: 831 DTKSQCHVSLDMVHLVHARKAQHLATDVGYKTAEHHFTALPTDMKVEWAKKAYGLQSDNQ 890
Query: 719 YRGQL----GRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVK 774
YR + G + + +E+ KK E IS KY Q +K + I DTP M +
Sbjct: 891 YRADVKWMKGMGWVATGSLNVEQAKKAGELISEKKYRQHPDALKF--TSIKDTPEMVQAR 948
Query: 775 EAQNHISMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYK 822
+ Y E E K +TP D P + N +S+ YK
Sbjct: 949 ISYTQAVDRLYREQGENIK-HHYTPTADLPEVLLAKLNAMNISETRYK 995
Score = 171 bits (432), Expect = 4e-42
Identities = 204/823 (24%), Positives = 348/823 (42%), Gaps = 90/823 (10%)
Query: 26 DQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFIS 85
D++ + V + ME A+K EL S + YK ++S + T D P+ + A +S
Sbjct: 688 DELKFTSVTDSSQMEHAKKSQELQSGVAYKAGNEQSVHQYTISKDEPLFLQARANAANLS 747
Query: 86 EAKYKGTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKG-FSDYAHMKE 144
E YK + + + R+ + + + A L SEV YK+ ++ ++G ++
Sbjct: 748 EKLYKSSWENQKAKGFELRLDS-LTFLAAKAKRDLASEVKYKEDYERSRGKLIGAKDVQG 806
Query: 145 PPEVKHAMEVNKHQSNISYRKDVQDTHTYS-AELDRPDIKMATQISKIISNAEYKKGQGI 203
++ H+++++K QS + Y+K +DT + LD + A + + ++ YK +
Sbjct: 807 DSQMSHSLQMSKLQSELEYKKGFEDTKSQCHVSLDMVHLVHARKAQHLATDVGYKTAEHH 866
Query: 204 MNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHH-YNPLESASFRQNQLAAT 262
P + VE +K + ++ ++ ++K K + S + Q + A
Sbjct: 867 FTALPT-------DMKVEWAKKAYGLQSDNQYRADVKWMKGMGWVATGSLNVEQAKKAGE 919
Query: 263 LASNVKYKKDIQNMH-DPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADA 321
L S KY++ + + D P ++ + R Y++ E K Y AD
Sbjct: 920 LISEKKYRQHPDALKFTSIKDTPEMV---QARISYTQAVDRLYREQGENIKHHYTPTADL 976
Query: 322 VEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEK 381
E L K NA+ S+ +YKE + K + ++ +QA+K + ++ S+ YKE FEK
Sbjct: 977 PEVLLAKLNAMNISETRYKESWSKLRDGGYKLRLDALPFQAAKASGEIISDYKYKEAFEK 1036
Query: 382 EIKGR--SSLDLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKR 439
+KG+ S L+ H Y T+L + YKK E+ + L+ L AK+
Sbjct: 1037 -MKGQMLGSRSLEDDISLAHSVYATSLQSDVNYKKGFEHSKAQFHLPLDMAAL--VHAKK 1093
Query: 440 ASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGM 499
A +AS ++YK L + + L + AKKA ++ SE Y+ DL ++G
Sbjct: 1094 AQTLASNQDYKHPLPQYT------SLAEDLRLSCAKKAHKLQSENLYRSDLNF-MRGVAC 1146
Query: 500 QVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRK 559
V TL+++ KKASE+ S+ +Y++ + K + D P++L AK +++I ++R
Sbjct: 1147 -VIPGTLEIEGRKKASELISESKYRQH-PHSFKYTAVT---DTPNLLHAKFSNQITNERL 1201
Query: 560 YKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKKEVGAGTAVKDSPEIERVKKNQQ 619
YK E Y T PE R K N
Sbjct: 1202 YKAAGEDARHEY-------------------------------TMTLGLPEFIRAKTNAA 1230
Query: 620 NISSVKYKEEIKHATAIS-----DPPELKRVKENQKNISNLQY-----KEQNYKATPVSM 669
N+S +YKE ++ A + + + + S+ Y KE+ P S+
Sbjct: 1231 NLSDARYKESWRNLRAQGYKLTIEALPFQAARASGDIASDFLYRHDFVKERGKLIGPQSV 1290
Query: 670 T--PEIERVRRNQEQLSAVKYKGELQRGTAIS--------DPPELKRAKENQKNISNVYY 719
P I+ RR + S ++Y+ RG S D L AK Q S+ Y
Sbjct: 1291 RDDPRIQHCRRMGQLQSELQYR----RGATSSQAQFHLPMDMVHLVHAKNAQALASDHDY 1346
Query: 720 RGQLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNH 779
R Q + T L +M KK S ++Y D MKG L L +P M K+A
Sbjct: 1347 RTQYHKFTALPEDLKMAWAKKAHALQSELRYKSDLIGMKGIGWLALRSPQMESAKKAGEL 1406
Query: 780 ISMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYK 822
IS KY + + K FT VVD P + + ++ Y+
Sbjct: 1407 ISETKYRKKPDSIK---FTTVVDSPDLVHAKNSYMHCNERMYR 1446
Score = 162 bits (409), Expect = 2e-39
Identities = 150/566 (26%), Positives = 254/566 (44%), Gaps = 43/566 (7%)
Query: 294 KASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLE 353
KA+++ S EYK+ +E + D E L K A LQS V+Y E+YE+ +GK
Sbjct: 183 KANQLASQVEYKRGHDERISRFSTVVDTPELLRSKAGAQLQSDVRYTEDYEQQRGKGSFP 242
Query: 354 FVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPEFLHVKYITNLLRE---K 410
+ TP+YQ +K A ++ S+ Y + ++KE++G + P +T + +
Sbjct: 243 AMITPAYQIAKRANELASDVRYHQQYQKEMRGMAG------PAIGAEGILTRECADQYGQ 296
Query: 411 EYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKKDLESIIKGKG---MQAGTD 467
Y ++ E E +GKG Q AK+A E+AS+ +Y++D +KG D
Sbjct: 297 GYPEEYE-EHRGKGSFPAMITPAYQNAKKAHELASDIKYRQDFNK-MKGAAHYHSLPAQD 354
Query: 468 TLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDL 527
L ++ A+ ++ SE YK + + ++G+ V D + A K +AS YK D
Sbjct: 355 NLVLKQAQSVNKLVSENKYKENYQNHMRGRYEGVGMDRRTL-HAMKVGSLASNVAYKADY 413
Query: 528 ENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQ 587
+++I ++ P A + + Y+ +K+ YS++ DTP+I + K
Sbjct: 414 KHDIVDYNYPATL-TPSYQTAMKLVPL-KDANYRQSIDKL--KYSSVTDTPQIVQAKINA 469
Query: 588 QNISAVFYKKEVGAG----TAVKDSPEIERVKKNQQNISSVKYKE-----EIKHATAISD 638
Q +S V Y+ + T +D P++ + K N + S VKYKE + K D
Sbjct: 470 QQLSHVNYRADYEKNKLNYTLPQDVPQLVKAKTNAKLFSEVKYKEGWEKTKGKGFEMKLD 529
Query: 639 PPELKRVKENQKNISNLQYKEQNYKATPVSMTPEIERVRRN---QEQLSAVKYKGELQ-- 693
L K + + SN++YKE+ K +M R+ + + S V+YK +
Sbjct: 530 AMSLLAAKASGELASNIKYKEEYEKTKGKAMGTADSRLLHSLQIAKMSSEVEYKKGFEES 589
Query: 694 --RGTAISDPPELKRAKENQKNISNVYYRGQLGRATTLSVTPEMERVKKNQENISSVKYT 751
R D ++ AK+ Q S++ YR +L T L + + KK S ++Y
Sbjct: 590 KTRFHLPMDMVNIRHAKKAQTLASDLDYRKKLHEYTVLPEDMKTQWAKKAYGLQSELQYK 649
Query: 752 QDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEKTKGRGFTPVVDDPVTERVRK 811
D MKG L + + K+A +S Y + ++ K FT V D E +K
Sbjct: 650 ADLAWMKGVGWLTEGSLNLEQAKKAGQLVSEKNYRQRVDELK---FTSVTDSSQMEHAKK 706
Query: 812 NTQVVSDAAYK-----GVHPHIVEMD 832
+ ++ S AYK VH + + D
Sbjct: 707 SQELQSGVAYKAGNEQSVHQYTISKD 732
Score = 160 bits (406), Expect = 4e-39
Identities = 195/804 (24%), Positives = 338/804 (42%), Gaps = 82/804 (10%)
Query: 36 DLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKYKGTIKA 95
D+ +E A+K L SD +Y+ + K K T S + K G ISE KY+ A
Sbjct: 873 DMKVEWAKKAYGLQSDNQYRADVKWMKGMGWVATGSLNVEQAKKAGELISEKKYRQHPDA 932
Query: 96 DLSNSLYKRMPATIDS--VFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMKEPPEVK---- 149
L + K P + + + V +L E KH Y + PEV
Sbjct: 933 -LKFTSIKDTPEMVQARISYTQAVDRLYREQGENIKHH-------YTPTADLPEVLLAKL 984
Query: 150 HAMEVNKHQSNISYRKDVQDTHTYSAELDRPDIKMATQISKIISNAEYK----KGQGIMN 205
+AM +++ + S+ K ++D Y LD + A +IIS+ +YK K +G M
Sbjct: 985 NAMNISETRYKESWSK-LRDGG-YKLRLDALPFQAAKASGEIISDYKYKEAFEKMKGQML 1042
Query: 206 KEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLAS 265
++ H+V A+ L S + YK+ F++ K + PL+ A+ + A TLAS
Sbjct: 1043 GSRSLEDDISLAHSVYATSLQSDVNYKKGFEHS---KAQFHLPLDMAALVHAKKAQTLAS 1099
Query: 266 NVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHL 325
N YK + DL L KA K+ S Y+ +G+ +E
Sbjct: 1100 NQDYKHPLPQYTSLAEDLR----LSCAKKAHKLQSENLYRSDLNFMRGVACVIPGTLEIE 1155
Query: 326 HHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYK---EDFEKE 382
K + L S+ KY++ K + +TP+ +K + ++ +E++YK ED E
Sbjct: 1156 GRKKASELISESKYRQHPHSFKYTAV---TDTPNLLHAKFSNQITNERLYKAAGEDARHE 1212
Query: 383 IKGRSSLDLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASE 442
L PEF+ K L + YK+ N ++ +G +L E L Q A+ + +
Sbjct: 1213 YTMTLGL-----PEFIRAKTNAANLSDARYKESWRN-LRAQGYKLTIEALPFQAARASGD 1266
Query: 443 MASEKEYKKDLESIIKGK--GMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQ 500
+AS+ Y+ D +GK G Q+ D +QH ++ ++ SE Y+R +
Sbjct: 1267 IASDFLYRHDFVKE-RGKLIGPQSVRDDPRIQHCRRMGQLQSELQYRRGATSS--QAQFH 1323
Query: 501 VSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILR---AKRTSEIYSQ 557
+ D + + AK A +AS Y+ +P+ L+ AK+ + S+
Sbjct: 1324 LPMDMVHLVHAKNAQALASDHDYRTQYHKFTA---------LPEDLKMAWAKKAHALQSE 1374
Query: 558 RKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKKEVGA--GTAVKDSPEIERVK 615
+YK + M +P+++ K + IS Y+K+ + T V DSP++ K
Sbjct: 1375 LRYKSDLIGMKGIGWLALRSPQMESAKKAGELISETKYRKKPDSIKFTTVVDSPDLVHAK 1434
Query: 616 KNQQNISSVKYK----EEIKHATAISDPPELKRVKENQKNISNLQYKEQNYKATPVSMTP 671
+ + + Y+ E + T I D P+ R + N ++S+ Y+ + S
Sbjct: 1435 NSYMHCNERMYRSGDAESLHRYTLIPDHPDFTRARLNALHLSDKVYRNSWEQTRAGSYDF 1494
Query: 672 EIERV-----RRNQEQLSAVKYKGELQRGT-------AISDPPELKRAKENQKNISNVYY 719
++ + R ++E S +YK R ++ D P +K + S+ Y
Sbjct: 1495 RLDAIPFQTARASREIASDFRYKEAFLRDRGLQIGYRSVDDDPRMKHFLNVGRLQSDNEY 1554
Query: 720 RGQLGRATTL----SVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKE 775
+ ++ + + P + + K++Q+ S V Y Q Q P + +RH ++
Sbjct: 1555 KKDFAKSRSQFHSSTDQPGLLQAKRSQQLASDVHYRQPLPQPTCDPEQL----GLRHAQK 1610
Query: 776 AQNHISMVKYHEDFEKTKGRGFTP 799
A S VKY D T+G G+TP
Sbjct: 1611 AHQLQSDVKYKSDLNLTRGVGWTP 1634
Score = 142 bits (358), Expect = 2e-33
Identities = 170/740 (22%), Positives = 310/740 (41%), Gaps = 83/740 (11%)
Query: 16 EKIGEEENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDK-CTFVTDSPML 74
+++ E+ E + Y P + + LA+ IS+ RYKE + K +D D+
Sbjct: 956 DRLYREQGENIKHHYTPTADLPEVLLAKLNAMNISETRYKESWSKLRDGGYKLRLDALPF 1015
Query: 75 NHVKNIGAFISEAKYKGTIKADLSNSLYKR-MPATIDSVFAGEVTQLQSEVAYKQKHDAA 133
K G IS+ KYK + L R + I + T LQS+V YK+ + +
Sbjct: 1016 QAAKASGEIISDYKYKEAFEKMKGQMLGSRSLEDDISLAHSVYATSLQSDVNYKKGFEHS 1075
Query: 134 KGFSDYAHMKEPPEVKHAMEVNKHQSNISYRKDVQDTHTYSAELDRPDIKMATQISKIIS 193
K + + + + HA + SN Y+ + + + +L + A + K+ S
Sbjct: 1076 K--AQFHLPLDMAALVHAKKAQTLASNQDYKHPLPQYTSLAEDLR---LSCAKKAHKLQS 1130
Query: 194 NAEYKKGQGIMNKEPAVI-GRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESA 252
Y+ M VI G + E +AS+L S+ KY++
Sbjct: 1131 ENLYRSDLNFMRGVACVIPGTLEIEGRKKASELISESKYRQ----------------HPH 1174
Query: 253 SFRQNQLAATLASNVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENK 312
SF+ + V+D PNLL H ++++ + R YK E+ +
Sbjct: 1175 SFK---------------------YTAVTDTPNLL---HAKFSNQITNERLYKAAGEDAR 1210
Query: 313 GMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSE 372
Y E + K NA S +YKE + + + +E +QA++ + + S+
Sbjct: 1211 HEYTMTLGLPEFIRAKTNAANLSDARYKESWRNLRAQGYKLTIEALPFQAARASGDIASD 1270
Query: 373 KVYKEDFEKE---IKGRSSLDLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNS 429
+Y+ DF KE + G S+ D P H + + L E +Y++ + L
Sbjct: 1271 FLYRHDFVKERGKLIGPQSVRDD--PRIQHCRRMGQLQSELQYRRGATS--SQAQFHLPM 1326
Query: 430 EVLDIQRAKRASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRD 489
+++ + AK A +AS+ +Y+ A + L+M AKKA + SE YK D
Sbjct: 1327 DMVHLVHAKNAQALASDHDYRTQYHK------FTALPEDLKMAWAKKAHALQSELRYKSD 1380
Query: 490 LETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAK 549
L +KG G ++ + ++ AKKA E+ S+ +Y+K + IK +D PD++ AK
Sbjct: 1381 L-IGMKGIGW-LALRSPQMESAKKAGELISETKYRKK-PDSIK---FTTVVDSPDLVHAK 1434
Query: 550 RTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKK-----EVGAGTA 604
+ ++R Y+ + L Y+ I D P+ R + ++S Y+ G+
Sbjct: 1435 NSYMHCNERMYRSGDAESLHRYTLIPDHPDFTRARLNALHLSDKVYRNSWEQTRAGSYDF 1494
Query: 605 VKDSPEIERVKKNQQNISSVKYKEEIKH-------ATAISDPPELKRVKENQKNISNLQY 657
D+ + + +++ S +YKE ++ D P +K + S+ +Y
Sbjct: 1495 RLDAIPFQTARASREIASDFRYKEAFLRDRGLQIGYRSVDDDPRMKHFLNVGRLQSDNEY 1554
Query: 658 KEQNYKAT----PVSMTPEIERVRRNQEQLSAVKYKGELQRGTAISDPPELKRAKENQKN 713
K+ K+ + P + + +R+Q+ S V Y+ L + T + L+ A++ +
Sbjct: 1555 KKDFAKSRSQFHSSTDQPGLLQAKRSQQLASDVHYRQPLPQPTCDPEQLGLRHAQKAHQL 1614
Query: 714 ISNVYYRGQLGRATTLSVTP 733
S+V Y+ L + TP
Sbjct: 1615 QSDVKYKSDLNLTRGVGWTP 1634
Score = 37.0 bits (84), Expect = 0.094
Identities = 19/61 (31%), Positives = 32/61 (52%), Gaps = 1/61 (1%)
Query: 765 LDTPAMRHVKEAQNHISMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGV 824
L P + + EA+ + +Y ED+E+ +G+G P + P +R +K Q+ S YK
Sbjct: 138 LPDPEIVRMVEARKSLGE-EYTEDYEQPRGKGSFPAMITPAYQRAKKANQLASQVEYKRG 196
Query: 825 H 825
H
Sbjct: 197 H 197
>gi|46049105 nebulin-related anchoring protein isoform S [Homo
sapiens]
Length = 1730
Score = 194 bits (493), Expect = 4e-49
Identities = 198/822 (24%), Positives = 376/822 (45%), Gaps = 57/822 (6%)
Query: 26 DQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFIS 85
D++ Y V + + A+ + +S + Y+ +++K+K T D P L K S
Sbjct: 484 DKLKYSSVTDTPQIVQAKINAQQLSHVNYRADYEKNKLNYTLPQDVPQLVKAKTNAKLFS 543
Query: 86 EAKYKGTIKADLSNSLYKRMPATIDSVFAGEVT-QLQSEVAYKQKHDAAKGFSDYAHMKE 144
E KYK + ++ A S+ A + + +L S + YK++++ KG A
Sbjct: 544 EVKYKEGWEKTKGKGFEMKLDAM--SLLAAKASGELASNIKYKEEYEKTKG---KAMGTA 598
Query: 145 PPEVKHAMEVNKHQSNISYRKDVQDTHT-YSAELDRPDIKMATQISKIISNAEYKKGQGI 203
+ H++++ K S + Y+K +++ T + +D +I+ A + + S+ +Y+K
Sbjct: 599 DSRLLHSLQIAKMSSEVEYKKGFEESKTRFHLPMDMVNIRHAKKAQTLASDLDYRKK--- 655
Query: 204 MNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATL 263
+++ + + A +A L S+++YK K + S + Q + A L
Sbjct: 656 LHEYTVLPEDMKTQWAKKAYGLQSELQYKADL---AWMKGVGWLTEGSLNLEQAKKAGQL 712
Query: 264 ASNVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVE 323
S Y++ + + + + + ++H K+ ++ SG YK E++ Y D
Sbjct: 713 VSEKNYRQRVDELK--FTSVTDSSQMEHAKKSQELQSGVAYKAGNEQSVHQYTISKDEPL 770
Query: 324 HLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEI 383
L + NA S+ YK +E K K +++ ++ A+K + + SE YKED+E+
Sbjct: 771 FLQARANAANLSEKLYKSSWENQKAKGFELRLDSLTFLAAKAKRDLASEVKYKEDYERS- 829
Query: 384 KGR--SSLDLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRAS 441
+G+ + D+ + H ++ L E EYKK E+ ++ +++ + A++A
Sbjct: 830 RGKLIGAKDVQGDSQMSHSLQMSKLQSELEYKKGFED--TKSQCHVSLDMVHLVHARKAQ 887
Query: 442 EMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQV 501
+A++ YK A ++++ AKKA + S+ Y+ D++ +KG G V
Sbjct: 888 HLATDVGYK------TAEHHFTALPTDMKVEWAKKAYGLQSDNQYRADVKW-MKGMGW-V 939
Query: 502 STDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYK 561
+T +L+V++AKKA E+ S+K+Y++ + +K ++ D P++++A+ + R Y+
Sbjct: 940 ATGSLNVEQAKKAGELISEKKYRQH-PDALKFTSIK---DTPEMVQARISYTQAVDRLYR 995
Query: 562 DEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKK-----EVGAGTAVKDSPEIERVKK 616
++ E + +Y+ AD PE+ K NIS YK+ G D+ + K
Sbjct: 996 EQGENIKHHYTPTADLPEVLLAKLNAMNISETRYKESWSKLRDGGYKLRLDALPFQAAKA 1055
Query: 617 NQQNISSVKYKE-------EIKHATAISDPPELKRVKENQKNISNLQYKE--QNYKA--- 664
+ + IS KYKE ++ + ++ D L S++ YK+ ++ KA
Sbjct: 1056 SGEIISDYKYKEAFEKMKGQMLGSRSLEDDISLAHSVYATSLQSDVNYKKGFEHSKAQFH 1115
Query: 665 TPVSMTPEIERVRRNQEQLSAVKYKGELQRGTAISDPPELKRAKENQKNISNVYYRGQL- 723
P+ M + ++ Q S YK L + T++++ L AK+ K S YR L
Sbjct: 1116 LPLDMA-ALVHAKKAQTLASNQDYKHPLPQYTSLAEDLRLSCAKKAHKLQSENLYRSDLN 1174
Query: 724 ---GRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHI 780
G A + T E+E KK E IS KY Q K + + DTP + H K N I
Sbjct: 1175 FMRGVACVIPGTLEIEGRKKASELISESKYRQHPHSFK--YTAVTDTPNLLHAK-FSNQI 1231
Query: 781 SMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYK 822
+ + ++ + +T + P R + N +SDA YK
Sbjct: 1232 TNERLYKAAGEDARHEYTMTLGLPEFIRAKTNAANLSDARYK 1273
Score = 191 bits (484), Expect = 4e-48
Identities = 216/827 (26%), Positives = 360/827 (43%), Gaps = 99/827 (11%)
Query: 32 PVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKYKG 91
P ++L ++ A+ +L+S++ YK++ + S+ ++P +V I F S+ KYK
Sbjct: 351 PAQDNLVLKQAQSVNKLVSEVEYKKDLESSRGHSINYCETPQFRNVSKISKFTSDNKYKE 410
Query: 92 TIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYK--QKHDAAKGFSDYAHMKE-PPEV 148
+ + Y+ + ++ A +V L S VAYK KHD DY + P
Sbjct: 411 NYQNHM-RGRYEGVGMDRRTLHAMKVGSLASNVAYKADYKHDIV----DYNYPATLTPSY 465
Query: 149 KHAMEVNKHQSNISYRKDVQDTHTYSAELDRPDIKM----ATQISKIISNAEYKKGQGIM 204
+ AM++ + +YR+ + D YS+ D P I A Q+S + A+Y+K +
Sbjct: 466 QTAMKL-VPLKDANYRQSI-DKLKYSSVTDTPQIVQAKINAQQLSHVNYRADYEKNKLNY 523
Query: 205 NKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLA 264
V P A +KL S++KYKE + E K L++ S + + LA
Sbjct: 524 TLPQDV---PQLVKAKTNAKLFSEVKYKEGW--EKTKGKGFEMKLDAMSLLAAKASGELA 578
Query: 265 SNVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEH 324
SN+KYK++ + + L H L+ +KM S EYKK FEE+K +H D V
Sbjct: 579 SNIKYKEEYEKTKGKAMGTADSRLL-HSLQIAKMSSEVEYKKGFEESKTRFHLPMDMVNI 637
Query: 325 LHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIK 384
H K L S + Y+++ + P E Q +K+A +QSE YK D
Sbjct: 638 RHAKKAQTLASDLDYRKKLHEYTVLP-----EDMKTQWAKKAYGLQSELQYKADLA---- 688
Query: 385 GRSSLDLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMA 444
+KG G L L++++AK+A ++
Sbjct: 689 ----------------------------------WMKGVGW-LTEGSLNLEQAKKAGQLV 713
Query: 445 SEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTD 504
SEK Y++ ++ + + TD+ +M+HAKK+ E+ S YK E + +S D
Sbjct: 714 SEKNYRQRVDEL----KFTSVTDSSQMEHAKKSQELQSGVAYKAGNEQSV--HQYTISKD 767
Query: 505 TLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEA 564
+A+ + S+K YK EN+ K KG ++ +D L AK ++ S+ KYK++
Sbjct: 768 EPLFLQARANAANLSEKLYKSSWENQ-KAKGFELRLDSLTFLAAKAKRDLASEVKYKEDY 826
Query: 565 E----KMLSNYSTIADTPEIQRIKTTQQNISAVFYKK---EVGAGTAVK-DSPEIERVKK 616
E K++ D+ ++ ++ S + YKK + + V D + +K
Sbjct: 827 ERSRGKLIGAKDVQGDSQMSHSLQMSKLQ-SELEYKKGFEDTKSQCHVSLDMVHLVHARK 885
Query: 617 NQQNISSVKYKEEIKHATAISDPPELKRVKENQKNISNLQY-------KEQNYKATPVSM 669
Q + V YK H TA+ +++ K+ S+ QY K + AT
Sbjct: 886 AQHLATDVGYKTAEHHFTALPTDMKVEWAKKAYGLQSDNQYRADVKWMKGMGWVATG--- 942
Query: 670 TPEIERVRRNQEQLSAVKYK--GELQRGTAISDPPELKRAKENQKNISNVYYRGQ----L 723
+ +E+ ++ E +S KY+ + + T+I D PE+ +A+ + + YR Q
Sbjct: 943 SLNVEQAKKAGELISEKKYRQHPDALKFTSIKDTPEMVQARISYTQAVDRLYREQGENIK 1002
Query: 724 GRATTLSVTPEMERVKKNQENISSVKYTQDHKQMK-GRPSLILDTPAMRHVKEAQNHISM 782
T + PE+ K N NIS +Y + +++ G L LD + K + IS
Sbjct: 1003 HHYTPTADLPEVLLAKLNAMNISETRYKESWSKLRDGGYKLRLDALPFQAAKASGEIISD 1062
Query: 783 VKYHEDFEKTKGR--GFTPVVDDPVTERVRKNTQVVSDAAYKGVHPH 827
KY E FEK KG+ G + DD T + SD YK H
Sbjct: 1063 YKYKEAFEKMKGQMLGSRSLEDDISLAHSVYATSLQSDVNYKKGFEH 1109
Score = 189 bits (481), Expect = 9e-48
Identities = 235/925 (25%), Positives = 385/925 (41%), Gaps = 137/925 (14%)
Query: 3 VPVFEDIKDETEEEKIGEEENEE-DQVFYK---PVIEDLSMELARKCTELISDIRYKEEF 58
+P E ++ + +GEE E+ +Q K P + + + A+K +L S + YK
Sbjct: 138 LPDPEIVRMVEARKSLGEEYTEDYEQPRGKGSFPAMITPAYQRAKKANQLASQVEYKRGH 197
Query: 59 KKSKDKCTFVTDSPMLNHVKNIGAFISEAKYKGTIKADLSNSLYKRMPATIDSVF--AGE 116
+ + + V D+P L K S+ +Y + + PA I + A
Sbjct: 198 DERISRFSTVVDTPELLRSKAGAQLQSDVRYTEDYEQQRGKGSF---PAMITPAYQIAKR 254
Query: 117 VTQLQSEVAYKQKHD-----------AAKGF----------SDYAHMKE----------- 144
+L S+V Y Q++ A+G Y E
Sbjct: 255 ANELASDVRYHQQYQKEMRGMAGPAIGAEGILTRECADQYGQGYPEEYEEHRGKGSFPAM 314
Query: 145 -PPEVKHAMEVNKHQSNISYRKDVQDT------HTYSAELDRPDIKMATQISKIISNAEY 197
P ++A + ++ S+I YR+D H+ A+ D +K A ++K++S EY
Sbjct: 315 ITPAYQNAKKAHELASDIKYRQDFNKMKGAAHYHSLPAQ-DNLVLKQAQSVNKLVSEVEY 373
Query: 198 KKG-QGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQ 256
KK + P F + + SK +S KYKE + N M+ + E +
Sbjct: 374 KKDLESSRGHSINYCETPQFRNVSKISKFTSDNKYKENYQNHMRGR------YEGVGMDR 427
Query: 257 NQLAA----TLASNVKYKKDIQNMHD---------------------PVSDLPNLLFLDH 291
L A +LASNV YK D + HD P+ D +D
Sbjct: 428 RTLHAMKVGSLASNVAYKADYK--HDIVDYNYPATLTPSYQTAMKLVPLKDANYRQSIDK 485
Query: 292 VLKAS--------------KMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQSQV 337
+ +S + LS Y+ +E+NK Y D + + K NA L S+V
Sbjct: 486 LKYSSVTDTPQIVQAKINAQQLSHVNYRADYEKNKLNYTLPQDVPQLVKAKTNAKLFSEV 545
Query: 338 KYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPEF 397
KYKE +EK KGK ++ S A+K + ++ S YKE++EK KG++ D
Sbjct: 546 KYKEGWEKTKGKGFEMKLDAMSLLAAKASGELASNIKYKEEYEK-TKGKAMGTADS--RL 602
Query: 398 LHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKKDLESII 457
LH I + E EYKK E E K + L ++++I+ AK+A +AS+ +Y+K L
Sbjct: 603 LHSLQIAKMSSEVEYKKGFE-ESKTR-FHLPMDMVNIRHAKKAQTLASDLDYRKKLHE-- 658
Query: 458 KGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEM 517
+ ++ Q AKKA + SE YK DL +KG G ++ +L++++AKKA ++
Sbjct: 659 ----YTVLPEDMKTQWAKKAYGLQSELQYKADL-AWMKGVGW-LTEGSLNLEQAKKAGQL 712
Query: 518 ASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADT 577
S+K Y++ ++ E+K + D + AK++ E+ S YK E+ + Y+ D
Sbjct: 713 VSEKNYRQRVD-ELKFTSV---TDSSQMEHAKKSQELQSGVAYKAGNEQSVHQYTISKDE 768
Query: 578 PEIQRIKTTQQNISAVFYK----KEVGAGTAVK-DSPEIERVKKNQQNISSVKYKEEIKH 632
P + + N+S YK + G ++ DS K + S VKYKE+ +
Sbjct: 769 PLFLQARANAANLSEKLYKSSWENQKAKGFELRLDSLTFLAAKAKRDLASEVKYKEDYER 828
Query: 633 -------ATAISDPPELKRVKENQKNISNLQYK---EQNYKATPVSM-TPEIERVRRNQE 681
A + ++ + K S L+YK E VS+ + R+ Q
Sbjct: 829 SRGKLIGAKDVQGDSQMSHSLQMSKLQSELEYKKGFEDTKSQCHVSLDMVHLVHARKAQH 888
Query: 682 QLSAVKYKGELQRGTAISDPPELKRAKENQKNISNVYYRGQL----GRATTLSVTPEMER 737
+ V YK TA+ +++ AK+ S+ YR + G + + +E+
Sbjct: 889 LATDVGYKTAEHHFTALPTDMKVEWAKKAYGLQSDNQYRADVKWMKGMGWVATGSLNVEQ 948
Query: 738 VKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEKTKGRGF 797
KK E IS KY Q +K + I DTP M + + Y E E K +
Sbjct: 949 AKKAGELISEKKYRQHPDALKF--TSIKDTPEMVQARISYTQAVDRLYREQGENIK-HHY 1005
Query: 798 TPVVDDPVTERVRKNTQVVSDAAYK 822
TP D P + N +S+ YK
Sbjct: 1006 TPTADLPEVLLAKLNAMNISETRYK 1030
Score = 171 bits (432), Expect = 4e-42
Identities = 204/823 (24%), Positives = 348/823 (42%), Gaps = 90/823 (10%)
Query: 26 DQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFIS 85
D++ + V + ME A+K EL S + YK ++S + T D P+ + A +S
Sbjct: 723 DELKFTSVTDSSQMEHAKKSQELQSGVAYKAGNEQSVHQYTISKDEPLFLQARANAANLS 782
Query: 86 EAKYKGTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKG-FSDYAHMKE 144
E YK + + + R+ + + + A L SEV YK+ ++ ++G ++
Sbjct: 783 EKLYKSSWENQKAKGFELRLDS-LTFLAAKAKRDLASEVKYKEDYERSRGKLIGAKDVQG 841
Query: 145 PPEVKHAMEVNKHQSNISYRKDVQDTHTYS-AELDRPDIKMATQISKIISNAEYKKGQGI 203
++ H+++++K QS + Y+K +DT + LD + A + + ++ YK +
Sbjct: 842 DSQMSHSLQMSKLQSELEYKKGFEDTKSQCHVSLDMVHLVHARKAQHLATDVGYKTAEHH 901
Query: 204 MNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHH-YNPLESASFRQNQLAAT 262
P + VE +K + ++ ++ ++K K + S + Q + A
Sbjct: 902 FTALPT-------DMKVEWAKKAYGLQSDNQYRADVKWMKGMGWVATGSLNVEQAKKAGE 954
Query: 263 LASNVKYKKDIQNMH-DPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADA 321
L S KY++ + + D P ++ + R Y++ E K Y AD
Sbjct: 955 LISEKKYRQHPDALKFTSIKDTPEMV---QARISYTQAVDRLYREQGENIKHHYTPTADL 1011
Query: 322 VEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEK 381
E L K NA+ S+ +YKE + K + ++ +QA+K + ++ S+ YKE FEK
Sbjct: 1012 PEVLLAKLNAMNISETRYKESWSKLRDGGYKLRLDALPFQAAKASGEIISDYKYKEAFEK 1071
Query: 382 EIKGR--SSLDLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKR 439
+KG+ S L+ H Y T+L + YKK E+ + L+ L AK+
Sbjct: 1072 -MKGQMLGSRSLEDDISLAHSVYATSLQSDVNYKKGFEHSKAQFHLPLDMAAL--VHAKK 1128
Query: 440 ASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGM 499
A +AS ++YK L + + L + AKKA ++ SE Y+ DL ++G
Sbjct: 1129 AQTLASNQDYKHPLPQYT------SLAEDLRLSCAKKAHKLQSENLYRSDLNF-MRGVAC 1181
Query: 500 QVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRK 559
V TL+++ KKASE+ S+ +Y++ + K + D P++L AK +++I ++R
Sbjct: 1182 -VIPGTLEIEGRKKASELISESKYRQH-PHSFKYTAVT---DTPNLLHAKFSNQITNERL 1236
Query: 560 YKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKKEVGAGTAVKDSPEIERVKKNQQ 619
YK E Y T PE R K N
Sbjct: 1237 YKAAGEDARHEY-------------------------------TMTLGLPEFIRAKTNAA 1265
Query: 620 NISSVKYKEEIKHATAIS-----DPPELKRVKENQKNISNLQY-----KEQNYKATPVSM 669
N+S +YKE ++ A + + + + S+ Y KE+ P S+
Sbjct: 1266 NLSDARYKESWRNLRAQGYKLTIEALPFQAARASGDIASDFLYRHDFVKERGKLIGPQSV 1325
Query: 670 T--PEIERVRRNQEQLSAVKYKGELQRGTAIS--------DPPELKRAKENQKNISNVYY 719
P I+ RR + S ++Y+ RG S D L AK Q S+ Y
Sbjct: 1326 RDDPRIQHCRRMGQLQSELQYR----RGATSSQAQFHLPMDMVHLVHAKNAQALASDHDY 1381
Query: 720 RGQLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNH 779
R Q + T L +M KK S ++Y D MKG L L +P M K+A
Sbjct: 1382 RTQYHKFTALPEDLKMAWAKKAHALQSELRYKSDLIGMKGIGWLALRSPQMESAKKAGEL 1441
Query: 780 ISMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYK 822
IS KY + + K FT VVD P + + ++ Y+
Sbjct: 1442 ISETKYRKKPDSIK---FTTVVDSPDLVHAKNSYMHCNERMYR 1481
Score = 164 bits (414), Expect = 5e-40
Identities = 152/596 (25%), Positives = 263/596 (44%), Gaps = 68/596 (11%)
Query: 294 KASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLE 353
KA+++ S EYK+ +E + D E L K A LQS V+Y E+YE+ +GK
Sbjct: 183 KANQLASQVEYKRGHDERISRFSTVVDTPELLRSKAGAQLQSDVRYTEDYEQQRGKGSFP 242
Query: 354 FVETPSYQASKEAQKMQSEKVYKEDFEKEI------------------------------ 383
+ TP+YQ +K A ++ S+ Y + ++KE+
Sbjct: 243 AMITPAYQIAKRANELASDVRYHQQYQKEMRGMAGPAIGAEGILTRECADQYGQGYPEEY 302
Query: 384 ---KGRSSLDLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLD---IQRA 437
+G+ S TP + + K L + +Y++D N++KG + D +++A
Sbjct: 303 EEHRGKGSFPAMITPAYQNAKKAHELASDIKYRQDF-NKMKGAAHYHSLPAQDNLVLKQA 361
Query: 438 KRASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGK 497
+ +++ SE EYKKDLES +G + +T + ++ K ++ S+ YK + + ++G+
Sbjct: 362 QSVNKLVSEVEYKKDLES-SRGHSINY-CETPQFRNVSKISKFTSDNKYKENYQNHMRGR 419
Query: 498 GMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQ 557
V D + A K +AS YK D +++I ++ P A + +
Sbjct: 420 YEGVGMDRRTL-HAMKVGSLASNVAYKADYKHDIVDYNYPATL-TPSYQTAMKLVPL-KD 476
Query: 558 RKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKKEVGAG----TAVKDSPEIER 613
Y+ +K+ YS++ DTP+I + K Q +S V Y+ + T +D P++ +
Sbjct: 477 ANYRQSIDKL--KYSSVTDTPQIVQAKINAQQLSHVNYRADYEKNKLNYTLPQDVPQLVK 534
Query: 614 VKKNQQNISSVKYKE-----EIKHATAISDPPELKRVKENQKNISNLQYKEQNYKATPVS 668
K N + S VKYKE + K D L K + + SN++YKE+ K +
Sbjct: 535 AKTNAKLFSEVKYKEGWEKTKGKGFEMKLDAMSLLAAKASGELASNIKYKEEYEKTKGKA 594
Query: 669 MTPEIERVRRN---QEQLSAVKYKGELQ----RGTAISDPPELKRAKENQKNISNVYYRG 721
M R+ + + S V+YK + R D ++ AK+ Q S++ YR
Sbjct: 595 MGTADSRLLHSLQIAKMSSEVEYKKGFEESKTRFHLPMDMVNIRHAKKAQTLASDLDYRK 654
Query: 722 QLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHIS 781
+L T L + + KK S ++Y D MKG L + + K+A +S
Sbjct: 655 KLHEYTVLPEDMKTQWAKKAYGLQSELQYKADLAWMKGVGWLTEGSLNLEQAKKAGQLVS 714
Query: 782 MVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYK-----GVHPHIVEMD 832
Y + ++ K FT V D E +K+ ++ S AYK VH + + D
Sbjct: 715 EKNYRQRVDELK---FTSVTDSSQMEHAKKSQELQSGVAYKAGNEQSVHQYTISKD 767
Score = 160 bits (406), Expect = 4e-39
Identities = 195/804 (24%), Positives = 338/804 (42%), Gaps = 82/804 (10%)
Query: 36 DLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKYKGTIKA 95
D+ +E A+K L SD +Y+ + K K T S + K G ISE KY+ A
Sbjct: 908 DMKVEWAKKAYGLQSDNQYRADVKWMKGMGWVATGSLNVEQAKKAGELISEKKYRQHPDA 967
Query: 96 DLSNSLYKRMPATIDS--VFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMKEPPEVK---- 149
L + K P + + + V +L E KH Y + PEV
Sbjct: 968 -LKFTSIKDTPEMVQARISYTQAVDRLYREQGENIKHH-------YTPTADLPEVLLAKL 1019
Query: 150 HAMEVNKHQSNISYRKDVQDTHTYSAELDRPDIKMATQISKIISNAEYK----KGQGIMN 205
+AM +++ + S+ K ++D Y LD + A +IIS+ +YK K +G M
Sbjct: 1020 NAMNISETRYKESWSK-LRDGG-YKLRLDALPFQAAKASGEIISDYKYKEAFEKMKGQML 1077
Query: 206 KEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLAS 265
++ H+V A+ L S + YK+ F++ K + PL+ A+ + A TLAS
Sbjct: 1078 GSRSLEDDISLAHSVYATSLQSDVNYKKGFEHS---KAQFHLPLDMAALVHAKKAQTLAS 1134
Query: 266 NVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHL 325
N YK + DL L KA K+ S Y+ +G+ +E
Sbjct: 1135 NQDYKHPLPQYTSLAEDLR----LSCAKKAHKLQSENLYRSDLNFMRGVACVIPGTLEIE 1190
Query: 326 HHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYK---EDFEKE 382
K + L S+ KY++ K + +TP+ +K + ++ +E++YK ED E
Sbjct: 1191 GRKKASELISESKYRQHPHSFKYTAV---TDTPNLLHAKFSNQITNERLYKAAGEDARHE 1247
Query: 383 IKGRSSLDLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASE 442
L PEF+ K L + YK+ N ++ +G +L E L Q A+ + +
Sbjct: 1248 YTMTLGL-----PEFIRAKTNAANLSDARYKESWRN-LRAQGYKLTIEALPFQAARASGD 1301
Query: 443 MASEKEYKKDLESIIKGK--GMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQ 500
+AS+ Y+ D +GK G Q+ D +QH ++ ++ SE Y+R +
Sbjct: 1302 IASDFLYRHDFVKE-RGKLIGPQSVRDDPRIQHCRRMGQLQSELQYRRGATSS--QAQFH 1358
Query: 501 VSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILR---AKRTSEIYSQ 557
+ D + + AK A +AS Y+ +P+ L+ AK+ + S+
Sbjct: 1359 LPMDMVHLVHAKNAQALASDHDYRTQYHKFTA---------LPEDLKMAWAKKAHALQSE 1409
Query: 558 RKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKKEVGA--GTAVKDSPEIERVK 615
+YK + M +P+++ K + IS Y+K+ + T V DSP++ K
Sbjct: 1410 LRYKSDLIGMKGIGWLALRSPQMESAKKAGELISETKYRKKPDSIKFTTVVDSPDLVHAK 1469
Query: 616 KNQQNISSVKYK----EEIKHATAISDPPELKRVKENQKNISNLQYKEQNYKATPVSMTP 671
+ + + Y+ E + T I D P+ R + N ++S+ Y+ + S
Sbjct: 1470 NSYMHCNERMYRSGDAESLHRYTLIPDHPDFTRARLNALHLSDKVYRNSWEQTRAGSYDF 1529
Query: 672 EIERV-----RRNQEQLSAVKYKGELQRGT-------AISDPPELKRAKENQKNISNVYY 719
++ + R ++E S +YK R ++ D P +K + S+ Y
Sbjct: 1530 RLDAIPFQTARASREIASDFRYKEAFLRDRGLQIGYRSVDDDPRMKHFLNVGRLQSDNEY 1589
Query: 720 RGQLGRATTL----SVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKE 775
+ ++ + + P + + K++Q+ S V Y Q Q P + +RH ++
Sbjct: 1590 KKDFAKSRSQFHSSTDQPGLLQAKRSQQLASDVHYRQPLPQPTCDPEQL----GLRHAQK 1645
Query: 776 AQNHISMVKYHEDFEKTKGRGFTP 799
A S VKY D T+G G+TP
Sbjct: 1646 AHQLQSDVKYKSDLNLTRGVGWTP 1669
Score = 142 bits (358), Expect = 2e-33
Identities = 170/740 (22%), Positives = 310/740 (41%), Gaps = 83/740 (11%)
Query: 16 EKIGEEENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDK-CTFVTDSPML 74
+++ E+ E + Y P + + LA+ IS+ RYKE + K +D D+
Sbjct: 991 DRLYREQGENIKHHYTPTADLPEVLLAKLNAMNISETRYKESWSKLRDGGYKLRLDALPF 1050
Query: 75 NHVKNIGAFISEAKYKGTIKADLSNSLYKR-MPATIDSVFAGEVTQLQSEVAYKQKHDAA 133
K G IS+ KYK + L R + I + T LQS+V YK+ + +
Sbjct: 1051 QAAKASGEIISDYKYKEAFEKMKGQMLGSRSLEDDISLAHSVYATSLQSDVNYKKGFEHS 1110
Query: 134 KGFSDYAHMKEPPEVKHAMEVNKHQSNISYRKDVQDTHTYSAELDRPDIKMATQISKIIS 193
K + + + + HA + SN Y+ + + + +L + A + K+ S
Sbjct: 1111 K--AQFHLPLDMAALVHAKKAQTLASNQDYKHPLPQYTSLAEDLR---LSCAKKAHKLQS 1165
Query: 194 NAEYKKGQGIMNKEPAVI-GRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESA 252
Y+ M VI G + E +AS+L S+ KY++
Sbjct: 1166 ENLYRSDLNFMRGVACVIPGTLEIEGRKKASELISESKYRQ----------------HPH 1209
Query: 253 SFRQNQLAATLASNVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENK 312
SF+ + V+D PNLL H ++++ + R YK E+ +
Sbjct: 1210 SFK---------------------YTAVTDTPNLL---HAKFSNQITNERLYKAAGEDAR 1245
Query: 313 GMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSE 372
Y E + K NA S +YKE + + + +E +QA++ + + S+
Sbjct: 1246 HEYTMTLGLPEFIRAKTNAANLSDARYKESWRNLRAQGYKLTIEALPFQAARASGDIASD 1305
Query: 373 KVYKEDFEKE---IKGRSSLDLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNS 429
+Y+ DF KE + G S+ D P H + + L E +Y++ + L
Sbjct: 1306 FLYRHDFVKERGKLIGPQSVRDD--PRIQHCRRMGQLQSELQYRRGATS--SQAQFHLPM 1361
Query: 430 EVLDIQRAKRASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRD 489
+++ + AK A +AS+ +Y+ A + L+M AKKA + SE YK D
Sbjct: 1362 DMVHLVHAKNAQALASDHDYRTQYHK------FTALPEDLKMAWAKKAHALQSELRYKSD 1415
Query: 490 LETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAK 549
L +KG G ++ + ++ AKKA E+ S+ +Y+K + IK +D PD++ AK
Sbjct: 1416 L-IGMKGIGW-LALRSPQMESAKKAGELISETKYRKK-PDSIK---FTTVVDSPDLVHAK 1469
Query: 550 RTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKK-----EVGAGTA 604
+ ++R Y+ + L Y+ I D P+ R + ++S Y+ G+
Sbjct: 1470 NSYMHCNERMYRSGDAESLHRYTLIPDHPDFTRARLNALHLSDKVYRNSWEQTRAGSYDF 1529
Query: 605 VKDSPEIERVKKNQQNISSVKYKEEIKH-------ATAISDPPELKRVKENQKNISNLQY 657
D+ + + +++ S +YKE ++ D P +K + S+ +Y
Sbjct: 1530 RLDAIPFQTARASREIASDFRYKEAFLRDRGLQIGYRSVDDDPRMKHFLNVGRLQSDNEY 1589
Query: 658 KEQNYKAT----PVSMTPEIERVRRNQEQLSAVKYKGELQRGTAISDPPELKRAKENQKN 713
K+ K+ + P + + +R+Q+ S V Y+ L + T + L+ A++ +
Sbjct: 1590 KKDFAKSRSQFHSSTDQPGLLQAKRSQQLASDVHYRQPLPQPTCDPEQLGLRHAQKAHQL 1649
Query: 714 ISNVYYRGQLGRATTLSVTP 733
S+V Y+ L + TP
Sbjct: 1650 QSDVKYKSDLNLTRGVGWTP 1669
Score = 139 bits (351), Expect = 1e-32
Identities = 139/519 (26%), Positives = 238/519 (45%), Gaps = 40/519 (7%)
Query: 338 KYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPEF 397
+Y E+YE+ +GK + TP+YQ +K+A ++ S+ YK ++ I R S +D TPE
Sbjct: 156 EYTEDYEQPRGKGSFPAMITPAYQRAKKANQLASQVEYKRGHDERI-SRFSTVVD-TPEL 213
Query: 398 LHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKKDLESII 457
L K L + Y +D E + +GKG Q AKRA+E+AS+ Y + + +
Sbjct: 214 LRSKAGAQLQSDVRYTEDYEQQ-RGKGSFPAMITPAYQIAKRANELASDVRYHQQYQKEM 272
Query: 458 KG-KGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASE 516
+G G G + + + ++Y+ E +GKG + T Q AKKA E
Sbjct: 273 RGMAGPAIGAEGILTRECADQYGQGYPEEYE-----EHRGKGSFPAMITPAYQNAKKAHE 327
Query: 517 MASQKQYKKDLENEIKGKGMQVSMDIPDIL---RAKRTSEIYSQRKYKDEAEKMLSNYST 573
+AS +Y++D N++KG S+ D L +A+ +++ S+ +YK + E +
Sbjct: 328 LASDIKYRQDF-NKMKGAAHYHSLPAQDNLVLKQAQSVNKLVSEVEYKKDLESSRGHSIN 386
Query: 574 IADTPEIQRIKTTQQNISAVFYKKEV-----GAGTAVKDSPEIERVKKNQQNISSVKYKE 628
+TP+ + + + S YK+ G V K S+V YK
Sbjct: 387 YCETPQFRNVSKISKFTSDNKYKENYQNHMRGRYEGVGMDRRTLHAMKVGSLASNVAYKA 446
Query: 629 EIKHATAISDPPELKRVKENQKNISNLQYKEQNY-------KATPVSMTPEIERVRRNQE 681
+ KH + P Q + + K+ NY K + V+ TP+I + + N +
Sbjct: 447 DYKHDIVDYNYP-ATLTPSYQTAMKLVPLKDANYRQSIDKLKYSSVTDTPQIVQAKINAQ 505
Query: 682 QLSAVKYKGELQRG----TAISDPPELKRAKENQKNISNVYYRGQLGRATTLSVTPEMER 737
QLS V Y+ + ++ T D P+L +AK N K S V Y+ + +++
Sbjct: 506 QLSHVNYRADYEKNKLNYTLPQDVPQLVKAKTNAKLFSEVKYKEGWEKTKGKGFEMKLDA 565
Query: 738 V-----KKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEKT 792
+ K + E S++KY +++++ KG+ D+ + H + S V+Y + FE++
Sbjct: 566 MSLLAAKASGELASNIKYKEEYEKTKGKAMGTADS-RLLHSLQIAKMSSEVEYKKGFEES 624
Query: 793 KGRGFTPVVDDPVTERVRKNTQ-VVSDAAY-KGVHPHIV 829
K R P+ D V R K Q + SD Y K +H + V
Sbjct: 625 KTRFHLPM--DMVNIRHAKKAQTLASDLDYRKKLHEYTV 661
>gi|5453710 LIM and SH3 protein 1 [Homo sapiens]
Length = 261
Score = 120 bits (302), Expect = 5e-27
Identities = 92/285 (32%), Positives = 128/285 (44%), Gaps = 60/285 (21%)
Query: 732 TPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEK 791
T +M KN + Y H K +++ DTP +K+ S V+Y E+FEK
Sbjct: 34 TCKMTLNMKNYKGYEKKPYCNAHYP-KQSFTMVADTPENLRLKQQSELQSQVRYKEEFEK 92
Query: 792 TKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVDLKVWRTDPGSI 851
KG+GF+ VV+D P + + + I ++K
Sbjct: 93 NKGKGFS----------------VVADT------PELQRIKKTQDQISNIK--------- 121
Query: 852 FDLDPLEDNIQSRSLHMLSEKASHYRRHWSRSHSSSTFGTGLGDDRSEISEIYPSFSCCS 911
Y + +S + G G+ +R + S+ S+
Sbjct: 122 ------------------------YHEEFEKSRMGPSGGEGMEPERRD-SQDGSSYRRPL 156
Query: 912 EVTRPSD--EGAPVLPGAYQQSHSQGYG-YMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQ 968
E +P APV QQ +Q YG Y + S++ + YRA+YDYSA
Sbjct: 157 EQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAA 216
Query: 969 DEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
DEDEVSF+DGD IVNVQ IDDGWMYGTV+RTG TGMLPANY+E +
Sbjct: 217 DEDEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTGMLPANYVEAI 261
Score = 60.5 bits (145), Expect = 8e-09
Identities = 34/95 (35%), Positives = 57/95 (60%), Gaps = 8/95 (8%)
Query: 711 QKNISNVYYRGQLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRP-SLILDTPA 769
+K N +Y Q T ++ TPE R+K+ E S V+Y ++ ++ KG+ S++ DTP
Sbjct: 49 KKPYCNAHYPKQ--SFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPE 106
Query: 770 MRHVKEAQNHISMVKYHEDFEKTK-----GRGFTP 799
++ +K+ Q+ IS +KYHE+FEK++ G G P
Sbjct: 107 LQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEP 141
Score = 60.5 bits (145), Expect = 8e-09
Identities = 33/69 (47%), Positives = 40/69 (57%)
Query: 319 ADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKED 378
AD E+L K + LQSQV+YKEE+EKNKGK +TP Q K+ Q S Y E+
Sbjct: 66 ADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEE 125
Query: 379 FEKEIKGRS 387
FEK G S
Sbjct: 126 FEKSRMGPS 134
Score = 52.4 bits (124), Expect = 2e-06
Identities = 28/67 (41%), Positives = 43/67 (64%), Gaps = 5/67 (7%)
Query: 570 NYSTIADTPEIQRIKTTQQNISAVFYKKEV----GAG-TAVKDSPEIERVKKNQQNISSV 624
+++ +ADTPE R+K + S V YK+E G G + V D+PE++R+KK Q IS++
Sbjct: 61 SFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNI 120
Query: 625 KYKEEIK 631
KY EE +
Sbjct: 121 KYHEEFE 127
Score = 51.2 bits (121), Expect = 5e-06
Identities = 27/67 (40%), Positives = 42/67 (62%), Gaps = 5/67 (7%)
Query: 603 TAVKDSPEIERVKKNQQNISSVKYKEEI-----KHATAISDPPELKRVKENQKNISNLQY 657
T V D+PE R+K+ + S V+YKEE K + ++D PEL+R+K+ Q ISN++Y
Sbjct: 63 TMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKY 122
Query: 658 KEQNYKA 664
E+ K+
Sbjct: 123 HEEFEKS 129
Score = 50.1 bits (118), Expect = 1e-05
Identities = 27/63 (42%), Positives = 38/63 (60%), Gaps = 1/63 (1%)
Query: 504 DTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDE 563
DT + R K+ SE+ SQ +YK++ E KGKG V D P++ R K+T + S KY +E
Sbjct: 67 DTPENLRLKQQSELQSQVRYKEEFEKN-KGKGFSVVADTPELQRIKKTQDQISNIKYHEE 125
Query: 564 AEK 566
EK
Sbjct: 126 FEK 128
Score = 48.5 bits (114), Expect = 3e-05
Identities = 33/114 (28%), Positives = 61/114 (53%), Gaps = 8/114 (7%)
Query: 649 QKNISNLQYKEQNYKATPVSMTPEIERVRRNQEQLSAVKYKGELQRG-----TAISDPPE 703
+K N Y +Q++ T V+ TPE R+++ E S V+YK E ++ + ++D PE
Sbjct: 49 KKPYCNAHYPKQSF--TMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPE 106
Query: 704 LKRAKENQKNISNVYYRGQLGRATTLSVTPE-MERVKKNQENISSVKYTQDHKQ 756
L+R K+ Q ISN+ Y + ++ E ME +++ ++ SS + + +Q
Sbjct: 107 LQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQ 160
Score = 45.4 bits (106), Expect = 3e-04
Identities = 22/66 (33%), Positives = 42/66 (63%), Gaps = 5/66 (7%)
Query: 634 TAISDPPELKRVKENQKNISNLQYKEQNYKA-----TPVSMTPEIERVRRNQEQLSAVKY 688
T ++D PE R+K+ + S ++YKE+ K + V+ TPE++R+++ Q+Q+S +KY
Sbjct: 63 TMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKY 122
Query: 689 KGELQR 694
E ++
Sbjct: 123 HEEFEK 128
Score = 43.5 bits (101), Expect = 0.001
Identities = 24/67 (35%), Positives = 35/67 (52%), Gaps = 1/67 (1%)
Query: 467 DTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKD 526
DT E K+ +E+ S+ YK + E KGKG V DT ++QR KK + S +Y ++
Sbjct: 67 DTPENLRLKQQSELQSQVRYKEEFEKN-KGKGFSVVADTPELQRIKKTQDQISNIKYHEE 125
Query: 527 LENEIKG 533
E G
Sbjct: 126 FEKSRMG 132
Score = 39.3 bits (90), Expect = 0.019
Identities = 27/100 (27%), Positives = 49/100 (49%), Gaps = 8/100 (8%)
Query: 394 TPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKKDL 453
TPE L +K + L + YK++ E KGKG + ++ ++QR K+ + S +Y ++
Sbjct: 68 TPENLRLKQQSELQSQVRYKEEFEKN-KGKGFSVVADTPELQRIKKTQDQISNIKYHEEF 126
Query: 454 ESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETE 493
E G G M+ ++ ++ S Y+R LE +
Sbjct: 127 EKSRMGPSGGEG-----MEPERRDSQDGS--SYRRPLEQQ 159
Score = 38.5 bits (88), Expect = 0.032
Identities = 21/45 (46%), Positives = 28/45 (62%), Gaps = 1/45 (2%)
Query: 46 TELISDIRYKEEFKKSKDK-CTFVTDSPMLNHVKNIGAFISEAKY 89
+EL S +RYKEEF+K+K K + V D+P L +K IS KY
Sbjct: 78 SELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKY 122
Score = 38.1 bits (87), Expect = 0.042
Identities = 22/61 (36%), Positives = 30/61 (49%), Gaps = 1/61 (1%)
Query: 436 RAKRASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIK 495
R K+ SE+ S+ YK++ E KGKG DT E+Q KK + S Y + E
Sbjct: 73 RLKQQSELQSQVRYKEEFEKN-KGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRM 131
Query: 496 G 496
G
Sbjct: 132 G 132
Score = 36.2 bits (82), Expect = 0.16
Identities = 31/88 (35%), Positives = 42/88 (47%), Gaps = 10/88 (11%)
Query: 270 KKDIQNMHDP------VSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGM-YHFDADAV 322
KK N H P V+D P L L + S++ S YK+ FE+NKG + AD
Sbjct: 49 KKPYCNAHYPKQSFTMVADTPENLRLK---QQSELQSQVRYKEEFEKNKGKGFSVVADTP 105
Query: 323 EHLHHKGNAVLQSQVKYKEEYEKNKGKP 350
E K S +KY EE+EK++ P
Sbjct: 106 ELQRIKKTQDQISNIKYHEEFEKSRMGP 133
Score = 35.8 bits (81), Expect = 0.21
Identities = 22/98 (22%), Positives = 48/98 (48%), Gaps = 6/98 (6%)
Query: 76 HVKNIGAFISEAKYKGTIKADLSNSLYKRMPATI-----DSVFAGEVTQLQSEVAYKQKH 130
H + ++ YKG K N+ Y + T+ +++ + ++LQS+V YK++
Sbjct: 31 HCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEF 90
Query: 131 DAAKGFSDYAHMKEPPEVKHAMEVNKHQSNISYRKDVQ 168
+ KG ++ + + PE++ + SNI Y ++ +
Sbjct: 91 EKNKG-KGFSVVADTPELQRIKKTQDQISNIKYHEEFE 127
>gi|169217576 PREDICTED: similar to nebulin [Homo sapiens]
Length = 410
Score = 91.3 bits (225), Expect = 4e-18
Identities = 103/428 (24%), Positives = 192/428 (44%), Gaps = 35/428 (8%)
Query: 220 VEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYKKDIQNM--- 276
+ A ++S+++ K+ D + K + +E + + + +AS KYK+ +
Sbjct: 6 INALQISNKLYQKDWNDTKQKGYDIRADAIE---IKHAKASREIASEYKYKEGYRKQLGH 62
Query: 277 ---HDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNAVL 333
+ D P ++ H A+K+ S REYKK +E++KG+++ D + + K VL
Sbjct: 63 HMGFRTLQDDPKSVWAIH---AAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVL 119
Query: 334 QSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDK 393
S + Y+ + P + +K+A +QS+ +YK D E +KG L +
Sbjct: 120 VSDIDYRNYLHQWTCLP-----DQNDVIQAKKAYDLQSDNLYKSDLE-WLKGIGWLP-EG 172
Query: 394 TPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNS--EVLDIQRAKRASEMASEKEYKK 451
+ E + VK NLL E+ Y+ IK + ++ S + ++ +AK + SE Y+
Sbjct: 173 SVEVMRVKNAQNLLNERLYR------IKPEALKFTSIVDTPEVIQAKINAVQISEPLYRN 226
Query: 452 DLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRA 511
E + + DT M +K A S K Y++ E ++K G + D + +Q A
Sbjct: 227 AWEK--EKANVNVPADTPLMLQSKINALQISNKRYQQAWE-DVKMTGYDLRADAIGIQHA 283
Query: 512 KKASEMASQKQYKKDLENEIKGK--GMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLS 569
K + ++AS YK E + KG G + + + P ++ A ++ + R YK +
Sbjct: 284 KASRDIASDYLYKTAYEKQ-KGHYIGCRSAKEDPKLVWAANVLKMQNDRLYKKAYNDHKA 342
Query: 570 NYSTIADTPEIQRIKTTQQNISAVFYKKEVGAGTAVKDSPEIERVKK--NQQNISSVKYK 627
S D I K Q S V Y+ + + D ++ + +K + Q+ SV +
Sbjct: 343 KISIPVDMVSISAAKEGQALASDVDYRHYLHHWSCFPDQNDVIQARKAYDLQSDVSVSPR 402
Query: 628 EEIKHATA 635
+++ H A
Sbjct: 403 KQVPHCFA 410
Score = 77.0 bits (188), Expect = 8e-14
Identities = 83/349 (23%), Positives = 140/349 (40%), Gaps = 43/349 (12%)
Query: 519 SQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSN---YSTIA 575
S K Y+KD N+ K KG + D +I AK + EI S+ KYK+ K L + + T+
Sbjct: 12 SNKLYQKDW-NDTKQKGYDIRADAIEIKHAKASREIASEYKYKEGYRKQLGHHMGFRTLQ 70
Query: 576 DTPE----IQRIKTTQQNISAVFYKKEVGAGTAVKDSPEIERVKKNQQNISSVKYKEEIK 631
D P+ I K Y+K G D I + KK Q +S + Y+ +
Sbjct: 71 DDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLH 130
Query: 632 HATAISDPPELKRVKENQKNISNLQYKEQNYKATPVSMTPEIERVRRNQEQLSAVKYKGE 691
T + D ++ + K+ S+ YK L +K G
Sbjct: 131 QWTCLPDQNDVIQAKKAYDLQSDNLYKSD----------------------LEWLKGIGW 168
Query: 692 LQRGTAISDPPELKRAKENQKNISNVYYR--GQLGRATTLSVTPEMERVKKNQENISSVK 749
L G+ E+ R K Q ++ YR + + T++ TPE+ + K N IS
Sbjct: 169 LPEGSV-----EVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEPL 223
Query: 750 YTQDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEKTKGRGFTPVVDDPVTERV 809
Y ++ K ++ DTP M K IS +Y + +E K G+ D +
Sbjct: 224 YRNAWEKEKANVNVPADTPLMLQSKINALQISNKRYQQAWEDVKMTGYDLRADAIGIQHA 283
Query: 810 RKNTQVVSDAAYKGVHPHIVEMDRRPGIIVDLKVWRTDPGSIFDLDPLE 858
+ + + SD YK + +++ G + + + DP ++ + L+
Sbjct: 284 KASRDIASDYLYKTAY------EKQKGHYIGCRSAKEDPKLVWAANVLK 326
Score = 69.7 bits (169), Expect = 1e-11
Identities = 99/442 (22%), Positives = 179/442 (40%), Gaps = 60/442 (13%)
Query: 119 QLQSEVAYKQKHDAA-KGFSDYAHMKEPPEVKHAMEV-NKHQSNISYRKDVQDTHTYSAE 176
Q+ +++ K +D KG+ A E K + E+ ++++ YRK + +
Sbjct: 10 QISNKLYQKDWNDTKQKGYDIRADAIEIKHAKASREIASEYKYKEGYRKQLGHHMGFRTL 69
Query: 177 LDRPDIKMATQISKIISNAEYKKGQGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFD 236
D P A +KI S+ EYKK
Sbjct: 70 QDDPKSVWAIHAAKIQSDREYKKAY----------------------------------- 94
Query: 237 NEMKDKKHHYNPLESASFRQNQLAATLASNVKYKKDIQNMHDPVSDLPNLLFLDHVLKAS 296
K K H PL+ S Q + L S++ Y+ + + LP+ + KA
Sbjct: 95 --EKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQW----TCLPDQNDVIQAKKAY 148
Query: 297 KMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVE 356
+ S YK E KG+ +VE + K L ++ Y+ + E K V+
Sbjct: 149 DLQSDNLYKSDLEWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALK---FTSIVD 205
Query: 357 TPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPEFLHVKYITNLLREKEYKKDL 416
TP +K SE +Y+ +EKE K ++ D TP L K + K Y++
Sbjct: 206 TPEVIQAKINAVQISEPLYRNAWEKE-KANVNVPAD-TPLMLQSKINALQISNKRYQQAW 263
Query: 417 ENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKKDLESIIKGK--GMQAGTDTLEMQHA 474
E ++K G +L ++ + IQ AK + ++AS+ YK E KG G ++ + ++ A
Sbjct: 264 E-DVKMTGYDLRADAIGIQHAKASRDIASDYLYKTAYEK-QKGHYIGCRSAKEDPKLVWA 321
Query: 475 KKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGK 534
++ +++ YK+ + K K + + D + + AK+ +AS Y+ L +
Sbjct: 322 ANVLKMQNDRLYKK-AYNDHKAK-ISIPVDMVSISAAKEGQALASDVDYRHYLHH----- 374
Query: 535 GMQVSMDIPDILRAKRTSEIYS 556
D D+++A++ ++ S
Sbjct: 375 -WSCFPDQNDVIQARKAYDLQS 395
Score = 44.3 bits (103), Expect = 6e-04
Identities = 65/321 (20%), Positives = 124/321 (38%), Gaps = 27/321 (8%)
Query: 30 YKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKY 89
++ + +D A ++ SD YK+ ++KSK D + K +S+ Y
Sbjct: 66 FRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDY 125
Query: 90 KGTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMKEPPEVK 149
+ + + +P D + A + LQS+ YK + KG P
Sbjct: 126 RNYLHQ------WTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWL-----PEGSV 174
Query: 150 HAMEVNKHQSNISYR--KDVQDTHTYSAELDRPDIKMATQISKIISNAEYKKGQGIMNKE 207
M V Q+ ++ R + + +++ +D P++ A + IS Y+ KE
Sbjct: 175 EVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEPLYRNA---WEKE 231
Query: 208 PAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPL--ESASFRQNQLAATLAS 265
A + P + SK+++ +++ +D K L ++ + + + +AS
Sbjct: 232 KANVNVPADTPLMLQSKINALQISNKRYQQAWEDVKMTGYDLRADAIGIQHAKASRDIAS 291
Query: 266 NVKYKKDIQNMHD------PVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDA 319
+ YK + + P L++ +VL KM + R YKK + ++K
Sbjct: 292 DYLYKTAYEKQKGHYIGCRSAKEDPKLVWAANVL---KMQNDRLYKKAYNDHKAKISIPV 348
Query: 320 DAVEHLHHKGNAVLQSQVKYK 340
D V K L S V Y+
Sbjct: 349 DMVSISAAKEGQALASDVDYR 369
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 66.2 bits (160), Expect = 1e-10
Identities = 121/623 (19%), Positives = 261/623 (41%), Gaps = 48/623 (7%)
Query: 154 VNKHQSNISYRKDV-QDTHTYSAELDRPDIKMATQISKIISNAEYKKGQGIMNKEPAVIG 212
VNK +S +D+ + A++ + ++A Q S + E K ++ ++ I
Sbjct: 561 VNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHK---VIAEKDKQIK 617
Query: 213 RPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYKKD 272
+ + A E +L+S+ + E+KD ++ N L A ++ Q A + ++ +
Sbjct: 618 QTEDSLASERDRLTSK-------EEELKDIQN-MNFLLKAEVQKLQALANEQAAAAHELE 669
Query: 273 IQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNAV 332
V D + L+ L+ E+K L ++NK + + + N
Sbjct: 670 KMQQSVYVKD-DKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKD 728
Query: 333 LQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLD 392
+ Q++ + + K K + E +ET Q + + +++ + + KE++ + D
Sbjct: 729 VVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND 788
Query: 393 KTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKKD 452
+ V+ + ++ EK+ K IK L +E+L + ++ +++ + + +
Sbjct: 789 QVSFASLVEELKKVIHEKDGK------IKSVEELLEAELLKVANKEKTVQLSITSKVQ-E 841
Query: 453 LESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETE---IKGKGMQVSTDTLDVQ 509
L++++KGK Q T ++ +K ++A+ + +DL+ E +K +V+ L +
Sbjct: 842 LQNLLKGKEEQMNTMKAVLEEKEK--DLANTGKWLQDLQEENESLKAHVQEVAQHNL--K 897
Query: 510 RAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDIL-RAKRTSEIYSQRK-YKDEAEKM 567
A AS+ + K+ ENE+K + D+ + + ++ + K +K + E++
Sbjct: 898 EASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQL 957
Query: 568 LS-NYSTIADTPE----IQRIKTTQQNISAVFYKKEVGAGTAVKDSPEIERVKKNQQNIS 622
NY + P ++ I ++ IS ++ + + ++KD+ E +R K N
Sbjct: 958 KQQNYQQASSFPPHEELLKVISEREKEISGLWNELD-----SLKDAVEHQRKKNNDLREK 1012
Query: 623 SVKYKEEIKHATAISDPPELKRVKENQKNIS--NLQYKEQNYKATPVSMTPEIERVRRNQ 680
+ + E + + K KE Q+ + L+ KE K P P + +
Sbjct: 1013 NWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPS--NLSYGE 1070
Query: 681 EQLSAVKYKGELQRGTAISDPPE-----LKRAKENQKNISNVYYRGQLGRATTLSVTPEM 735
K E GT+ S+ + LK A E + + + A T + ++
Sbjct: 1071 WLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKL 1130
Query: 736 ERVKKNQENISSVKYTQDHKQMK 758
+R + +EN VK + HK +K
Sbjct: 1131 QRSVEQEENKWKVKVDESHKTIK 1153
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 63.2 bits (152), Expect = 1e-09
Identities = 126/659 (19%), Positives = 276/659 (41%), Gaps = 90/659 (13%)
Query: 154 VNKHQSNISYRKDV-QDTHTYSAELDRPDIKMATQISKIISNAEYKKGQGIMNKEPAVIG 212
VNK +S +D+ + A++ + ++A Q S + E K ++ ++ I
Sbjct: 561 VNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHK---VIAEKDKQIK 617
Query: 213 RPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYKKD 272
+ + A E +L+S+ + E+KD ++ N L A ++ Q A + ++ +
Sbjct: 618 QTEDSLASERDRLTSK-------EEELKDIQN-MNFLLKAEVQKLQALANEQAAAAHELE 669
Query: 273 IQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNAV 332
V D + L+ L+ E+K L ++NK + + + N
Sbjct: 670 KMQQSVYVKD-DKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKD 728
Query: 333 LQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLD 392
+ Q++ + + K K + E +ET Q + + +++ + + KE++ + D
Sbjct: 729 VVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND 788
Query: 393 KTPEFLHVKYITNLLREKEYK----------------------KDLENEIKGKGMELNSE 430
+ V+ + ++ EK+ K +DL+ EIK L E
Sbjct: 789 QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA----LKEE 844
Query: 431 VLDIQRAKRASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDL 490
+ ++Q K ++ S ++L++++KGK Q T ++ +K ++A+ + +DL
Sbjct: 845 IGNVQLEK--AQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEK--DLANTGKWLQDL 900
Query: 491 ETE---IKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDIL- 546
+ E +K +V+ L + A AS+ + K+ ENE+K + D+
Sbjct: 901 QEENESLKAHVQEVAQHNL--KEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSS 958
Query: 547 RAKRTSEIYSQRK-YKDEAEKMLS-NYSTIADTPE----IQRIKTTQQNISAVFYKKEVG 600
+ + ++ + K +K + E++ NY + P ++ I ++ IS ++ + +
Sbjct: 959 KTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELD-- 1016
Query: 601 AGTAVKDSPEIERVKKN--QQNISSVKY--KEEIKHA-TAISDPPEL----------KRV 645
++KD+ E +R K N QQ + +V+ KE +K +S P L K+
Sbjct: 1017 ---SLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKA 1073
Query: 646 KE------NQKNISNLQYKEQNYKATPVSMTPEIERVRRNQEQLSAVKYKGELQRGTAIS 699
KE + + L++K + + E E+ + + + K LQR
Sbjct: 1074 KECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQK--LQRSVEQE 1131
Query: 700 DPPELKRAKENQKNISNVYYRGQLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMK 758
+ + E+ K I + +++ S E+ER++ ++I +++ ++H +M+
Sbjct: 1132 ENKWKVKVDESHKTIKQM-------QSSFTSSEQELERLRSENKDIENLRREREHLEME 1183
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 62.8 bits (151), Expect = 2e-09
Identities = 32/80 (40%), Positives = 44/80 (55%), Gaps = 2/80 (2%)
Query: 931 SHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDG 990
SHS+G + SS + Q + YRAMY Y Q+EDE+ R+GD + +Q DDG
Sbjct: 591 SHSRGPSHPLDLGTSSPNTSQI--HWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDG 648
Query: 991 WMYGTVQRTGRTGMLPANYI 1010
W G +RT + G P NY+
Sbjct: 649 WFVGVSRRTQKFGTFPGNYV 668
Score = 46.6 bits (109), Expect = 1e-04
Identities = 18/51 (35%), Positives = 32/51 (62%)
Query: 961 AMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIE 1011
A Y + E E+SFR G++I ++ +++ W G + TGR G+ PA+Y++
Sbjct: 461 AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQ 511
Score = 42.0 bits (97), Expect = 0.003
Identities = 18/52 (34%), Positives = 30/52 (57%), Gaps = 2/52 (3%)
Query: 960 RAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIE 1011
R +D+ AQ E++ + GD + + +D W+ G + GR G+ PANY+E
Sbjct: 386 RLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEG--EHHGRLGIFPANYVE 435
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 62.8 bits (151), Expect = 2e-09
Identities = 32/80 (40%), Positives = 44/80 (55%), Gaps = 2/80 (2%)
Query: 931 SHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDG 990
SHS+G + SS + Q + YRAMY Y Q+EDE+ R+GD + +Q DDG
Sbjct: 249 SHSRGPSHPLDLGTSSPNTSQI--HWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDG 306
Query: 991 WMYGTVQRTGRTGMLPANYI 1010
W G +RT + G P NY+
Sbjct: 307 WFVGVSRRTQKFGTFPGNYV 326
Score = 46.6 bits (109), Expect = 1e-04
Identities = 18/51 (35%), Positives = 32/51 (62%)
Query: 961 AMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIE 1011
A Y + E E+SFR G++I ++ +++ W G + TGR G+ PA+Y++
Sbjct: 119 AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQ 169
Score = 42.0 bits (97), Expect = 0.003
Identities = 18/52 (34%), Positives = 30/52 (57%), Gaps = 2/52 (3%)
Query: 960 RAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIE 1011
R +D+ AQ E++ + GD + + +D W+ G + GR G+ PANY+E
Sbjct: 44 RLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEG--EHHGRLGIFPANYVE 93
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 62.8 bits (151), Expect = 2e-09
Identities = 34/86 (39%), Positives = 50/86 (58%), Gaps = 7/86 (8%)
Query: 926 GAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQ 985
G QQ +Q Q V+ RS Q S +L +Y+A+Y Y Q++DE+ RDGD + ++
Sbjct: 1069 GGSQQPQAQ------QRRVTPDRS-QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVME 1121
Query: 986 PIDDGWMYGTVQRTGRTGMLPANYIE 1011
DDGW GT +RT + G P NY++
Sbjct: 1122 KCDDGWFVGTSRRTKQFGTFPGNYVK 1147
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/91 (26%), Positives = 43/91 (47%), Gaps = 4/91 (4%)
Query: 923 VLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIV 982
V+P +Q ++ +G + ++ + +R RA +D+ AQ E+ + GD +
Sbjct: 786 VIPTHHQFITNERFGDL--LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVY 843
Query: 983 NVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
+ ID W G + GR G+ P YIE +
Sbjct: 844 IYKQIDQNWYEG--EHHGRVGIFPRTYIELL 872
Score = 42.0 bits (97), Expect = 0.003
Identities = 15/53 (28%), Positives = 31/53 (58%)
Query: 961 AMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
A ++++ + E+SFR G+ I ++ +D+ W G + T R G+ P Y++ +
Sbjct: 896 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 948
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 62.8 bits (151), Expect = 2e-09
Identities = 34/86 (39%), Positives = 50/86 (58%), Gaps = 7/86 (8%)
Query: 926 GAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQ 985
G QQ +Q Q V+ RS Q S +L +Y+A+Y Y Q++DE+ RDGD + ++
Sbjct: 1210 GGSQQPQAQ------QRRVTPDRS-QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVME 1262
Query: 986 PIDDGWMYGTVQRTGRTGMLPANYIE 1011
DDGW GT +RT + G P NY++
Sbjct: 1263 KCDDGWFVGTSRRTKQFGTFPGNYVK 1288
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/91 (26%), Positives = 43/91 (47%), Gaps = 4/91 (4%)
Query: 923 VLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIV 982
V+P +Q ++ +G + ++ + +R RA +D+ AQ E+ + GD +
Sbjct: 764 VIPTHHQFITNERFGDL--LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVY 821
Query: 983 NVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
+ ID W G + GR G+ P YIE +
Sbjct: 822 IYKQIDQNWYEG--EHHGRVGIFPRTYIELL 850
Score = 42.0 bits (97), Expect = 0.003
Identities = 15/53 (28%), Positives = 31/53 (58%)
Query: 961 AMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
A ++++ + E+SFR G+ I ++ +D+ W G + T R G+ P Y++ +
Sbjct: 874 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 926
>gi|239752495 PREDICTED: similar to nebulin [Homo sapiens]
Length = 237
Score = 62.4 bits (150), Expect = 2e-09
Identities = 49/158 (31%), Positives = 79/158 (50%), Gaps = 14/158 (8%)
Query: 437 AKRASEMASEKEYKKDLESIIKGKGMQ-AGTDTLEMQHAKKAAEIASEKDYKRDLETEIK 495
A A+++ S++EYKK E K KG+ D + + AKK + S+ DY+ L
Sbjct: 51 AIHAAKIQSDREYKKAYE---KSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQ--- 104
Query: 496 GKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIY 555
D DV +AKKA ++ S YK DLE +KG G + +++R K +
Sbjct: 105 ---WTCLPDQNDVIQAKKAYDLQSDNLYKSDLE-WLKGIGWLPEGSV-EVMRVKNAQNLL 159
Query: 556 SQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAV 593
++R Y+ + E + +++I DTPE+ + K IS V
Sbjct: 160 NERLYRIKPEAL--KFTSIVDTPEVIQAKINAVQISEV 195
Score = 55.1 bits (131), Expect = 3e-07
Identities = 46/171 (26%), Positives = 78/171 (45%), Gaps = 9/171 (5%)
Query: 523 YKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQR 582
Y+K L + + G + D P + A ++I S R+YK EK ++T D I +
Sbjct: 29 YRKQLGHHM---GFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQ 85
Query: 583 IKTTQQNISAVFYKKEVGAGTAVKDSPEIERVKKNQQNISSVKYKEEIKHATAISDPPE- 641
K Q +S + Y+ + T + D ++ + KK S YK +++ I PE
Sbjct: 86 AKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWLPEG 145
Query: 642 ---LKRVKENQKNISNLQY--KEQNYKATPVSMTPEIERVRRNQEQLSAVK 687
+ RVK Q ++ Y K + K T + TPE+ + + N Q+S V+
Sbjct: 146 SVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVE 196
Score = 53.9 bits (128), Expect = 7e-07
Identities = 46/162 (28%), Positives = 81/162 (50%), Gaps = 15/162 (9%)
Query: 293 LKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPML 352
+ A+K+ S REYKK +E++KG+++ D + + K VL S + Y+ + P
Sbjct: 52 IHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLP-- 109
Query: 353 EFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPEFLHVKYITNLLREKEY 412
+ +K+A +QS+ +YK D E +KG L + + E + VK NLL E+ Y
Sbjct: 110 ---DQNDVIQAKKAYDLQSDNLYKSDLE-WLKGIGWLP-EGSVEVMRVKNAQNLLNERLY 164
Query: 413 KKDLENEIKGKGMELNS--EVLDIQRAKRASEMASEKEYKKD 452
+ IK + ++ S + ++ +AK + SE E +D
Sbjct: 165 R------IKPEALKFTSIVDTPEVIQAKINAVQISEVEKSRD 200
Score = 48.5 bits (114), Expect = 3e-05
Identities = 52/193 (26%), Positives = 91/193 (47%), Gaps = 20/193 (10%)
Query: 338 KYKEEYEKNKGKPM--LEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTP 395
KYKE Y K G M + P + A K+QS++ YK+ +EK KG + LD
Sbjct: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKS-KGIHNTPLDMM- 81
Query: 396 EFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKKDLES 455
+ K L+ + +Y+ L + D+ +AK+A ++ S+ YK DLE
Sbjct: 82 SIVQAKKCQVLVSDIDYRNYLHQ------WTCLPDQNDVIQAKKAYDLQSDNLYKSDLE- 134
Query: 456 IIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVST--DTLDVQRAKK 513
+KG G ++E+ K A + +E+ Y+ IK + ++ ++ DT +V +AK
Sbjct: 135 WLKGIGW-LPEGSVEVMRVKNAQNLLNERLYR------IKPEALKFTSIVDTPEVIQAKI 187
Query: 514 ASEMASQKQYKKD 526
+ S+ + +D
Sbjct: 188 NAVQISEVEKSRD 200
Score = 46.2 bits (108), Expect = 2e-04
Identities = 46/172 (26%), Positives = 71/172 (41%), Gaps = 13/172 (7%)
Query: 559 KYKDEAEKMLSN---YSTIADTPE----IQRIKTTQQNISAVFYKKEVGAGTAVKDSPEI 611
KYK+ K L + + T+ D P+ I K Y+K G D I
Sbjct: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSI 83
Query: 612 ERVKKNQQNISSVKYKEEIKHATAISDPPELKRVKENQKNISNLQYKEQNYKATPVSMTP 671
+ KK Q +S + Y+ + T + D ++ + K+ S+ YK + P
Sbjct: 84 VQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWLP 143
Query: 672 ----EIERVRRNQEQLSAVKY--KGELQRGTAISDPPELKRAKENQKNISNV 717
E+ RV+ Q L+ Y K E + T+I D PE+ +AK N IS V
Sbjct: 144 EGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEV 195
Score = 39.7 bits (91), Expect = 0.015
Identities = 36/136 (26%), Positives = 62/136 (45%), Gaps = 7/136 (5%)
Query: 687 KYKGELQRGTAISDPP----ELKRAKENQKNISNVYYRGQLGRATTLSVTPEMERVKKNQ 742
+YK ++ I + P + +AK+ Q +S++ YR L + T L ++ + KK
Sbjct: 62 EYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAY 121
Query: 743 ENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEKTKGRGFTPVVD 802
+ S Y D + +KG L + + VK AQN ++ Y E K FT +VD
Sbjct: 122 DLQSDNLYKSDLEWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALK---FTSIVD 178
Query: 803 DPVTERVRKNTQVVSD 818
P + + N +S+
Sbjct: 179 TPEVIQAKINAVQISE 194
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 62.0 bits (149), Expect = 3e-09
Identities = 30/71 (42%), Positives = 45/71 (63%), Gaps = 1/71 (1%)
Query: 941 QTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTG 1000
Q V+ RS Q S +L +Y+A+Y Y Q++DE+ RDGD + ++ DDGW GT +RT
Sbjct: 667 QRRVTPDRS-QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTK 725
Query: 1001 RTGMLPANYIE 1011
+ G P NY++
Sbjct: 726 QFGTFPGNYVK 736
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/91 (26%), Positives = 43/91 (47%), Gaps = 4/91 (4%)
Query: 923 VLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIV 982
V+P +Q ++ +G + ++ + +R RA +D+ AQ E+ + GD +
Sbjct: 470 VIPTHHQFITNERFGDL--LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVY 527
Query: 983 NVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
+ ID W G + GR G+ P YIE +
Sbjct: 528 IYKQIDQNWYEG--EHHGRVGIFPRTYIELL 556
Score = 42.0 bits (97), Expect = 0.003
Identities = 15/53 (28%), Positives = 31/53 (58%)
Query: 961 AMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
A ++++ + E+SFR G+ I ++ +D+ W G + T R G+ P Y++ +
Sbjct: 580 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 632
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 62.0 bits (149), Expect = 3e-09
Identities = 30/71 (42%), Positives = 45/71 (63%), Gaps = 1/71 (1%)
Query: 941 QTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTG 1000
Q V+ RS Q S +L +Y+A+Y Y Q++DE+ RDGD + ++ DDGW GT +RT
Sbjct: 708 QRRVTPDRS-QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTK 766
Query: 1001 RTGMLPANYIE 1011
+ G P NY++
Sbjct: 767 QFGTFPGNYVK 777
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/91 (26%), Positives = 43/91 (47%), Gaps = 4/91 (4%)
Query: 923 VLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIV 982
V+P +Q ++ +G + ++ + +R RA +D+ AQ E+ + GD +
Sbjct: 511 VIPTHHQFITNERFGDL--LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVY 568
Query: 983 NVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
+ ID W G + GR G+ P YIE +
Sbjct: 569 IYKQIDQNWYEG--EHHGRVGIFPRTYIELL 597
Score = 42.0 bits (97), Expect = 0.003
Identities = 15/53 (28%), Positives = 31/53 (58%)
Query: 961 AMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
A ++++ + E+SFR G+ I ++ +D+ W G + T R G+ P Y++ +
Sbjct: 621 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 673
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 62.0 bits (149), Expect = 3e-09
Identities = 30/71 (42%), Positives = 45/71 (63%), Gaps = 1/71 (1%)
Query: 941 QTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTG 1000
Q V+ RS Q S +L +Y+A+Y Y Q++DE+ RDGD + ++ DDGW GT +RT
Sbjct: 832 QRRVTPDRS-QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTK 890
Query: 1001 RTGMLPANYIE 1011
+ G P NY++
Sbjct: 891 QFGTFPGNYVK 901
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/91 (26%), Positives = 43/91 (47%), Gaps = 4/91 (4%)
Query: 923 VLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIV 982
V+P +Q ++ +G + ++ + +R RA +D+ AQ E+ + GD +
Sbjct: 615 VIPTHHQFITNERFGDL--LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVY 672
Query: 983 NVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
+ ID W G + GR G+ P YIE +
Sbjct: 673 IYKQIDQNWYEG--EHHGRVGIFPRTYIELL 701
Score = 42.0 bits (97), Expect = 0.003
Identities = 15/53 (28%), Positives = 31/53 (58%)
Query: 961 AMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
A ++++ + E+SFR G+ I ++ +D+ W G + T R G+ P Y++ +
Sbjct: 725 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 777
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 62.0 bits (149), Expect = 3e-09
Identities = 30/71 (42%), Positives = 45/71 (63%), Gaps = 1/71 (1%)
Query: 941 QTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTG 1000
Q V+ RS Q S +L +Y+A+Y Y Q++DE+ RDGD + ++ DDGW GT +RT
Sbjct: 743 QRRVTPDRS-QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTK 801
Query: 1001 RTGMLPANYIE 1011
+ G P NY++
Sbjct: 802 QFGTFPGNYVK 812
Score = 46.2 bits (108), Expect = 2e-04
Identities = 99/446 (22%), Positives = 165/446 (36%), Gaps = 78/446 (17%)
Query: 600 GAGTAVKDSPEIERVKKN-----QQNISSVKYKEEIKHATAISDPPE--LKRVKENQKNI 652
GA ++ SP + V + Q SV +T I +P L+ +E QK +
Sbjct: 233 GAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRL 292
Query: 653 SNLQYKEQNYKATPVSMTPEIERVRRNQEQLSAVKYKGELQRGTAISDPPELKRAKENQK 712
S+L + PVS RR EQ SA + G AI KRAK++ +
Sbjct: 293 SSL--------SDPVSE-------RRVGEQDSAPTQEKPTSPGKAIE-----KRAKDDSR 332
Query: 713 NISNVYYRGQLGRATTLSVTPEMERVKKNQE-------NISSVKYTQDHKQMKGRPSLIL 765
+ V L + V + +++++ I + D R S
Sbjct: 333 RV--VKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSE 390
Query: 766 DTPAMRHVKEAQNHISMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVH 825
DT + V +++ +S + D EK R T P+ R ++ + S +
Sbjct: 391 DTKSPLSVPRSKSEMSYI----DGEKVVKRSATL----PLPAR---SSSLKSSSERNDWE 439
Query: 826 PHIVEMDRRPGIIVDLKVWRTDPGSIFDLDPLEDNI-----QSRSLHMLSEKASHYRRHW 880
P P VD + +R +P SI++ P + ++ S ++ E +S +
Sbjct: 440 P--------PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYI 491
Query: 881 --SRSHSSSTFGTGLGDDRSEIS---EIYPS--------FSCCSEVTRPSDEGAPVLPGA 927
S H+ G D + + +IY S S + RPS + +
Sbjct: 492 YSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSAST--KDS 549
Query: 928 YQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPI 987
H Y+ T +R +R RA +D+ AQ E+ + GD + + I
Sbjct: 550 ESPRHFIPADYLESTE-EFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI 608
Query: 988 DDGWMYGTVQRTGRTGMLPANYIEFV 1013
D W G + GR G+ P YIE +
Sbjct: 609 DQNWYEG--EHHGRVGIFPRTYIELL 632
Score = 42.0 bits (97), Expect = 0.003
Identities = 15/53 (28%), Positives = 31/53 (58%)
Query: 961 AMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
A ++++ + E+SFR G+ I ++ +D+ W G + T R G+ P Y++ +
Sbjct: 656 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 708
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 62.0 bits (149), Expect = 3e-09
Identities = 30/71 (42%), Positives = 45/71 (63%), Gaps = 1/71 (1%)
Query: 941 QTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTG 1000
Q V+ RS Q S +L +Y+A+Y Y Q++DE+ RDGD + ++ DDGW GT +RT
Sbjct: 611 QRRVTPDRS-QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTK 669
Query: 1001 RTGMLPANYIE 1011
+ G P NY++
Sbjct: 670 QFGTFPGNYVK 680
Score = 43.9 bits (102), Expect = 8e-04
Identities = 94/424 (22%), Positives = 157/424 (37%), Gaps = 73/424 (17%)
Query: 617 NQQNISSVKYKEEIKHATAISDPPE--LKRVKENQKNISNLQYKEQNYKATPVSMTPEIE 674
+ Q SV +T I +P L+ +E QK +S+L + PVS
Sbjct: 123 DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSL--------SDPVSE----- 169
Query: 675 RVRRNQEQLSAVKYKGELQRGTAISDPPELKRAKENQKNISNVYYRGQLGRATTLSVTPE 734
RR EQ SA + G AI KRAK++ + + V L + V
Sbjct: 170 --RRVGEQDSAPTQEKPTSPGKAIE-----KRAKDDSRRV--VKSTQDLSDVSMDEVGIP 220
Query: 735 MERVKKNQE-------NISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHE 787
+ +++++ I + D R S DT + V +++ +S +
Sbjct: 221 LRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYI---- 276
Query: 788 DFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVDLKVWRTD 847
D EK R T P+ R ++ + S + P P VD + +R +
Sbjct: 277 DGEKVVKRSATL----PLPAR---SSSLKSSSERNDWEP--------PDKKVDTRKYRAE 321
Query: 848 PGSIFDLDPLEDNI-----QSRSLHMLSEKASHYRRHW--SRSHSSSTFGTGLGDDRSEI 900
P SI++ P + ++ S ++ E +S + S H+ G D + +
Sbjct: 322 PKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSL 381
Query: 901 S---EIYPS--------FSCCSEVTRPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMRS 949
+IY S S + RPS + + H Y+ T +R
Sbjct: 382 ENERQIYKSVLEGGDIPLQGLSGLKRPSSSAST--KDSESPRHFIPADYLESTE-EFIRR 438
Query: 950 MQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANY 1009
+R RA +D+ AQ E+ + GD + + ID W G + GR G+ P Y
Sbjct: 439 RHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTY 496
Query: 1010 IEFV 1013
IE +
Sbjct: 497 IELL 500
Score = 42.0 bits (97), Expect = 0.003
Identities = 15/53 (28%), Positives = 31/53 (58%)
Query: 961 AMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
A ++++ + E+SFR G+ I ++ +D+ W G + T R G+ P Y++ +
Sbjct: 524 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 576
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 60.1 bits (144), Expect = 1e-08
Identities = 25/60 (41%), Positives = 41/60 (68%), Gaps = 2/60 (3%)
Query: 954 PNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
P R +A+YD+ ++EDE+SF+ GD I ++ +DD WM G + G++G+ P NYI+F+
Sbjct: 671 PKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELM--GKSGIFPKNYIQFL 728
Score = 43.9 bits (102), Expect = 8e-04
Identities = 18/51 (35%), Positives = 34/51 (66%), Gaps = 2/51 (3%)
Query: 961 AMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIE 1011
A ++Y + +DE+SF +G+ I+ + +++ W G V+ GRTG+ P N++E
Sbjct: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVE 567
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 60.1 bits (144), Expect = 1e-08
Identities = 25/60 (41%), Positives = 41/60 (68%), Gaps = 2/60 (3%)
Query: 954 PNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
P R +A+YD+ ++EDE+SF+ GD I ++ +DD WM G + G++G+ P NYI+F+
Sbjct: 707 PKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELM--GKSGIFPKNYIQFL 764
Score = 43.9 bits (102), Expect = 8e-04
Identities = 18/51 (35%), Positives = 34/51 (66%), Gaps = 2/51 (3%)
Query: 961 AMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIE 1011
A ++Y + +DE+SF +G+ I+ + +++ W G V+ GRTG+ P N++E
Sbjct: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVE 603
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 60.1 bits (144), Expect = 1e-08
Identities = 25/60 (41%), Positives = 41/60 (68%), Gaps = 2/60 (3%)
Query: 954 PNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
P R +A+YD+ ++EDE+SF+ GD I ++ +DD WM G + G++G+ P NYI+F+
Sbjct: 730 PKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELM--GKSGIFPKNYIQFL 787
Score = 43.9 bits (102), Expect = 8e-04
Identities = 18/51 (35%), Positives = 34/51 (66%), Gaps = 2/51 (3%)
Query: 961 AMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIE 1011
A ++Y + +DE+SF +G+ I+ + +++ W G V+ GRTG+ P N++E
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVE 626
>gi|20357552 cortactin isoform a [Homo sapiens]
Length = 550
Score = 58.9 bits (141), Expect = 2e-08
Identities = 35/95 (36%), Positives = 46/95 (48%), Gaps = 14/95 (14%)
Query: 929 QQSHSQGYGYMHQTSVSSMRSMQHSP-NLRTYR-----------AMYDYSAQDEDEVSFR 976
+ S QG Y + S + H P TY A+YDY A +DE+SF
Sbjct: 455 EASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFD 514
Query: 977 DGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIE 1011
D I N++ IDDGW G + GR G+ PANY+E
Sbjct: 515 PDDIITNIEMIDDGWWRGVCK--GRYGLFPANYVE 547
>gi|20357556 cortactin isoform b [Homo sapiens]
Length = 513
Score = 58.9 bits (141), Expect = 2e-08
Identities = 35/95 (36%), Positives = 46/95 (48%), Gaps = 14/95 (14%)
Query: 929 QQSHSQGYGYMHQTSVSSMRSMQHSP-NLRTYR-----------AMYDYSAQDEDEVSFR 976
+ S QG Y + S + H P TY A+YDY A +DE+SF
Sbjct: 418 EASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFD 477
Query: 977 DGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIE 1011
D I N++ IDDGW G + GR G+ PANY+E
Sbjct: 478 PDDIITNIEMIDDGWWRGVCK--GRYGLFPANYVE 510
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 57.8 bits (138), Expect = 5e-08
Identities = 183/862 (21%), Positives = 345/862 (40%), Gaps = 136/862 (15%)
Query: 5 VFEDIKDETEEEKIGEEENEEDQVFYKPVIEDLSMEL---ARKCTELISDIRYKEEFKKS 61
+ ED + T E E++ + K + D+ ME +K EL+ + E +K
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421
Query: 62 K--------------DKCTFVTDSPMLNHVKNIGAFISEAKYKGTIKADLSN-SLYK--- 103
+ + ++++P K++G ++E +K ++ N SL K
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQ----KSLGHEVNELTSSRLLKLEMENQSLTKTVE 477
Query: 104 RMPATIDSVF--AGEVTQLQSE---------------VAYKQKHDAAKGFSDYAHMKEPP 146
+ T+DSV A ++ +++ E V KQ + S MKE
Sbjct: 478 ELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDL-MKEKA 536
Query: 147 EVKHAMEVNKHQSNISYRKDVQDTHTYSAELDRPDIKMATQISKIISNAEYKKGQGIMNK 206
+++ +E + S + ++ + L++ + Q S+I + A K + K
Sbjct: 537 QLEKTIETLRENSE----RQIKILEQENEHLNQT-VSSLRQRSQISAEARVKD----IEK 587
Query: 207 EPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPL-ESASFRQNQLAATLAS 265
E ++ E E S S+I+++++ ++K + HY E A +N+L
Sbjct: 588 ENKIL----HESIKETSSKLSKIEFEKR---QIKKELEHYKEKGERAEELENELHHLEKE 640
Query: 266 NVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHL 325
N +K I N+ + L + L+ R+ KK + K + F +++E
Sbjct: 641 NELLQKKITNLKITCEKIEALEQENSELEREN----RKLKKTLDSFKNLT-FQLESLE-- 693
Query: 326 HHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKG 385
K N+ L +E E + L+ Q E ++++SEK E+ KG
Sbjct: 694 --KENSQLD-----EENLELRRNVESLKCASMKMAQLQLENKELESEK------EQLKKG 740
Query: 386 RSSLDLD-KTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMA 444
L K E L V Y + + +K LEN K K +L SE+ D++ + +
Sbjct: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNK-KIQQLESELQDLEMENQTLQKN 799
Query: 445 SE--KEYKKDLESIIK-GKGMQAGTDTLEMQHAKKAAEIASEKDYKR-DLETEIKGKGMQ 500
E K K LE + K K ++ T LE + EK+ KR + EIK ++
Sbjct: 800 LEELKISSKRLEQLEKENKSLEQETSQLEKDKKQL------EKENKRLRQQAEIKDTTLE 853
Query: 501 ---VSTDTLDVQRAKKASEMASQKQY---KKDLENEIKGKGMQVSMDIPDI--LRAKRTS 552
V L+ + + E+ K+ K+LE E K + ++DI + LR S
Sbjct: 854 ENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS 913
Query: 553 EIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKKEVGAGTAVKDSPEI- 611
E ++ ++ EK+ I E R+ +Q+ + E + +K S EI
Sbjct: 914 EKLKTQQMNNDLEKLTHELEKIGLNKE--RLLHDEQSTDDRYKLLESKLESTLKKSLEIK 971
Query: 612 -ERVKKNQQNIS-SVKYKEEIKHATAISDPPELKRVKENQKNISNLQYKEQNYKATPVSM 669
E++ + + S Y ++++ ELK VK+N + + Q +E+ +++P
Sbjct: 972 EEKIAALEARLEESTNYNQQLRQ--------ELKTVKKNYEALKQRQDEERMVQSSPPIS 1023
Query: 670 TPEIERVRRNQE---QLSAVKYK-GELQRGTAISD------PPELKRAKENQKNISN--V 717
+ + R +QE +L VK + E++R A +LK+ + N+ +
Sbjct: 1024 GEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQIL 1083
Query: 718 YYRGQLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRH----- 772
+ Q + T + + K EN S +Q M L++ ++ +
Sbjct: 1084 ALQRQTVSLQEQNTTLQTQNAKLQVEN--STLNSQSTSLMNQNAQLLIQQSSLENENESV 1141
Query: 773 VKEAQN----HISMVKYHEDFE 790
+KE ++ + S++K HE E
Sbjct: 1142 IKEREDLKSLYDSLIKDHEKLE 1163
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 57.4 bits (137), Expect = 7e-08
Identities = 185/863 (21%), Positives = 346/863 (40%), Gaps = 137/863 (15%)
Query: 5 VFEDIKDETEEEKIGEEENEEDQVFYKPVIEDLSMEL---ARKCTELISDIRYKEEFKKS 61
+ ED + T E E++ + K + D+ ME +K EL+ + E +K
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421
Query: 62 K--------------DKCTFVTDSPMLNHVKNIGAFISEAKYKGTIKADLSN-SLYK--- 103
+ + ++++P K++G ++E +K ++ N SL K
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQ----KSLGHEVNELTSSRLLKLEMENQSLTKTVE 477
Query: 104 RMPATIDSVF--AGEVTQLQSE---------------VAYKQKHDAAKGFSDYAHMKEPP 146
+ T+DSV A ++ +++ E V KQ + S MKE
Sbjct: 478 ELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDL-MKEKA 536
Query: 147 EVKHAMEVNKHQSNISYRKDVQDTHTYSAELDRPDIKMATQISKIISNAEYKKGQGIMNK 206
+++ +E + S + ++ + L++ + Q S+I + A K + K
Sbjct: 537 QLEKTIETLRENSE----RQIKILEQENEHLNQT-VSSLRQRSQISAEARVKD----IEK 587
Query: 207 EPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPL-ESASFRQNQLAATLAS 265
E ++ E E S S+I+++++ ++K + HY E A +N+L
Sbjct: 588 ENKIL----HESIKETSSKLSKIEFEKR---QIKKELEHYKEKGERAEELENELHHLEKE 640
Query: 266 NVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHL 325
N +K I N+ + L + L+ R+ KK + K + F +++E
Sbjct: 641 NELLQKKITNLKITCEKIEALEQENSELEREN----RKLKKTLDSFKNLT-FQLESLE-- 693
Query: 326 HHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKG 385
K N+ L +E E + L+ Q E ++++SEK E+ KG
Sbjct: 694 --KENSQLD-----EENLELRRNVESLKCASMKMAQLQLENKELESEK------EQLKKG 740
Query: 386 RSSLDLD-KTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMA 444
L K E L V Y + + +K LEN K K +L SE+ D++ + +
Sbjct: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNK-KIQQLESELQDLEMENQTLQKN 799
Query: 445 SE--KEYKKDLESIIK-GKGMQAGTDTLEMQHAKKAAEIASEKDYKR-DLETEIKGKGMQ 500
E K K LE + K K ++ T LE + EK+ KR + EIK ++
Sbjct: 800 LEELKISSKRLEQLEKENKSLEQETSQLEKDKKQL------EKENKRLRQQAEIKDTTLE 853
Query: 501 ---VSTDTLDVQRAKKASEMASQKQY---KKDLENEIKGKGMQVSMDIPDI--LRAKRTS 552
V L+ + + E+ K+ K+LE E K + ++DI + LR S
Sbjct: 854 ENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS 913
Query: 553 EIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKK-EVGAGTAVKDSPEI 611
E ++ ++ EK+ I E R+ +Q+ YK E + +K S EI
Sbjct: 914 EKLKTQQMNNDLEKLTHELEKIGLNKE--RLLHDEQSTDDSRYKLLESKLESTLKKSLEI 971
Query: 612 --ERVKKNQQNIS-SVKYKEEIKHATAISDPPELKRVKENQKNISNLQYKEQNYKATPVS 668
E++ + + S Y ++++ ELK VK+N + + Q +E+ +++P
Sbjct: 972 KEEKIAALEARLEESTNYNQQLRQ--------ELKTVKKNYEALKQRQDEERMVQSSPPI 1023
Query: 669 MTPEIERVRRNQE---QLSAVKYK-GELQRGTAISD------PPELKRAKENQKNISN-- 716
+ + R +QE +L VK + E++R A +LK+ + N+
Sbjct: 1024 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI 1083
Query: 717 VYYRGQLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRH---- 772
+ + Q + T + + K EN S +Q M L++ ++ +
Sbjct: 1084 LALQRQTVSLQEQNTTLQTQNAKLQVEN--STLNSQSTSLMNQNAQLLIQQSSLENENES 1141
Query: 773 -VKEAQN----HISMVKYHEDFE 790
+KE ++ + S++K HE E
Sbjct: 1142 VIKEREDLKSLYDSLIKDHEKLE 1164
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 55.8 bits (133), Expect = 2e-07
Identities = 25/69 (36%), Positives = 40/69 (57%), Gaps = 3/69 (4%)
Query: 946 SMRSMQHSPNL---RTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRT 1002
SM +++ P L YR + Y Q E E+ ++GD + + +DGW GT+QR GRT
Sbjct: 812 SMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRT 871
Query: 1003 GMLPANYIE 1011
G+ P +++E
Sbjct: 872 GLFPGSFVE 880
Score = 46.6 bits (109), Expect = 1e-04
Identities = 29/98 (29%), Positives = 49/98 (50%), Gaps = 6/98 (6%)
Query: 917 SDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTY-RAMYDYSAQDEDEVSF 975
S G+PV A S + G + + + S +P L Y +A+Y Y ++ ++ F
Sbjct: 159 STPGSPVFLSAAAGSTA---GSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKF 215
Query: 976 RDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
GD IV + +D+ W +G + G G LPA+YI+ +
Sbjct: 216 NKGDIIVLRRKVDEQWYHGELH--GTQGFLPASYIQCI 251
Score = 46.6 bits (109), Expect = 1e-04
Identities = 20/55 (36%), Positives = 28/55 (50%)
Query: 956 LRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYI 1010
L Y A+Y Y Q DE+ G+ ++ DGW G RTG +G+ P NY+
Sbjct: 466 LNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
Score = 32.3 bits (72), Expect = 2.3
Identities = 16/79 (20%), Positives = 42/79 (53%), Gaps = 8/79 (10%)
Query: 937 GYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDE----VSFRDGDYIVNVQPIDDGWM 992
G++ + + ++ + H+P +A+YD+ +D+D+ ++F + + ++ +D+ W
Sbjct: 241 GFLPASYIQCIQPLPHAPPQG--KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWA 298
Query: 993 YGTVQRTGRTGMLPANYIE 1011
G + + G+ P Y+E
Sbjct: 299 EGML--GDKIGIFPLLYVE 315
>gi|19224660 protein kinase C and casein kinase substrate in neurons 3
[Homo sapiens]
Length = 424
Score = 55.1 bits (131), Expect = 3e-07
Identities = 26/55 (47%), Positives = 39/55 (70%), Gaps = 2/55 (3%)
Query: 960 RAMYDYSAQDEDEVSFRDGDYIVNVQPIDD-GWMYGTVQRTGRTGMLPANYIEFV 1013
RA+YDY+ Q+ DE+SFR G+ ++ + D+ GW G +Q +GR G+ PANY+E V
Sbjct: 369 RALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQ-SGRIGLYPANYVECV 422
>gi|24308229 protein kinase C and casein kinase substrate in neurons 1
[Homo sapiens]
Length = 444
Score = 55.1 bits (131), Expect = 3e-07
Identities = 63/297 (21%), Positives = 127/297 (42%), Gaps = 31/297 (10%)
Query: 722 QLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHIS 781
++ T SVTPE + KK Q+ + K QD ++ + + +L+ + +N
Sbjct: 174 EMNSKTEQSVTPEQQ--KKLQDKVDKCK--QDVQKTQEKYEKVLEDVGKTTPQYMENMEQ 229
Query: 782 MVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVDL 841
+ + + FE+ + V+ D ++++ + +++Y V+ + + R DL
Sbjct: 230 VFEQCQQFEEKRLVFLKEVLLD-----IKRHLNLAENSSYIHVYRELEQAIRGADAQEDL 284
Query: 842 KVWRTDPGSIFDLD-PLEDNIQSRSLHMLSEKASHYRRHWSRSHSSSTFG---TGLGDDR 897
+ +R+ G ++ P + H ++K ++ + +++T T DR
Sbjct: 285 RWFRSTSGPGMPMNWPQFEEWNPDLPHTTTKKEKQPKKAEGVALTNATGAVESTSQAGDR 344
Query: 898 SEISEIYPSFSCCSEVTRPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLR 957
+S D G P +G +T+ + S +R
Sbjct: 345 GSVSSY--------------DRGQPYATEWSDDESGNPFGGS-ETNGGANPFEDDSKGVR 389
Query: 958 TYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDD-GWMYGTVQRTGRTGMLPANYIEFV 1013
RA+YDY Q++DE+SF+ GD + + D+ GW G + +G+ G+ PANY+E +
Sbjct: 390 V-RALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLD-SGQLGLYPANYVEAI 444
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 53.5 bits (127), Expect = 1e-06
Identities = 86/370 (23%), Positives = 148/370 (40%), Gaps = 80/370 (21%)
Query: 364 KEAQKMQSEKVYKEDFEKEIKGRSSLDLD------------------KTPEFLHVKYITN 405
+E +K ++EK + + + +GRSS+DL+ K + L K +
Sbjct: 516 EEKRKQKAEKT--KSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALS 573
Query: 406 LLREKEYKKDLENEIKGKGMELNS-EVLDIQRAKRASEMASEKEYKKDLESIIKGKGMQA 464
R+K+ + EN K + E +S E L +++S KE K K +
Sbjct: 574 KKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARR 633
Query: 465 GTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQ--KQ 522
+++L + K E E+++KR T + +G+Q TDT DV+R + SE+ ++ ++
Sbjct: 634 LSESLHVVDENKN-ESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQK 692
Query: 523 YKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQR 582
K L+NE + KD++E TP ++
Sbjct: 693 QKSTLKNE--------------------------KHLKKDDSE-----------TPHLKS 715
Query: 583 IKTTQQNISAVFYKKEVGAGTAVKDSPEIERVKKNQQNISSVKYKEEIKHATAISDPPEL 642
+ KKEV + K+ PE E+ + KYK + H T D EL
Sbjct: 716 L-----------LKKEVKSS---KEKPEREKTPSEDKLSVKHKYKGDCMHKT--GDETEL 759
Query: 643 KRVKENQKNISNLQYKEQNYKATPVSMTPEIERVRRNQEQLSAVKYKGELQRGTAISDPP 702
++ K N+Q + Q K + T E + RN+ +LS + G+ I
Sbjct: 760 HSSEKGLKVEENIQKQSQQTKLSSDDKT-ERKSKHRNERKLSVLGKDGKPVSEYIIKTDE 818
Query: 703 ELKRAKENQK 712
++ KEN K
Sbjct: 819 NVR--KENNK 826
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.351
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,445,051
Number of Sequences: 37866
Number of extensions: 1656365
Number of successful extensions: 9094
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 141
Number of HSP's successfully gapped in prelim test: 438
Number of HSP's that attempted gapping in prelim test: 6491
Number of HSP's gapped (non-prelim): 1356
length of query: 1014
length of database: 18,247,518
effective HSP length: 112
effective length of query: 902
effective length of database: 14,006,526
effective search space: 12633886452
effective search space used: 12633886452
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.