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Search of human proteins with 5453754
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5453754 NCK adaptor protein 1 [Homo sapiens]
(377 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 777 0.0
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 541 e-154
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 541 e-154
gi|52630427 NCK adaptor protein 2 isoform B [Homo sapiens] 133 2e-31
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 106 3e-23
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 104 1e-22
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 100 2e-21
gi|5729856 GRB2-related adaptor protein [Homo sapiens] 100 2e-21
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 98 1e-20
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 98 1e-20
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 98 1e-20
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 83 5e-16
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 83 5e-16
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 83 5e-16
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 82 1e-15
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 82 1e-15
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 82 1e-15
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 82 1e-15
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 82 1e-15
gi|193220941 hypothetical protein LOC400581 [Homo sapiens] 81 1e-15
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 80 3e-15
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 80 3e-15
gi|187475373 c-src tyrosine kinase [Homo sapiens] 80 3e-15
gi|4758078 c-src tyrosine kinase [Homo sapiens] 80 3e-15
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 80 3e-15
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 78 1e-14
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 78 1e-14
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 77 3e-14
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 77 3e-14
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 77 3e-14
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 777 bits (2007), Expect = 0.0
Identities = 377/377 (100%), Positives = 377/377 (100%)
Query: 1 MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKN 60
MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKN
Sbjct: 1 MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKN 60
Query: 61 SARKASIVKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAE 120
SARKASIVKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAE
Sbjct: 61 SARKASIVKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAE 120
Query: 121 REDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLA 180
REDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLA
Sbjct: 121 REDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLA 180
Query: 181 AVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVG 240
AVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVG
Sbjct: 181 AVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVG 240
Query: 241 LVPKNYVTVMQNNPLTSGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERG 300
LVPKNYVTVMQNNPLTSGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERG
Sbjct: 241 LVPKNYVTVMQNNPLTSGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERG 300
Query: 301 HEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVEHYKKAP 360
HEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVEHYKKAP
Sbjct: 301 HEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVEHYKKAP 360
Query: 361 IFTSEQGEKLYLVKHLS 377
IFTSEQGEKLYLVKHLS
Sbjct: 361 IFTSEQGEKLYLVKHLS 377
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 541 bits (1394), Expect = e-154
Identities = 264/382 (69%), Positives = 307/382 (80%), Gaps = 9/382 (2%)
Query: 1 MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKN 60
M EEV+V+AK+DY AQQ+QELDIKKNERLWLLDDSK+WWRVRN+ N+TG+VPSNYVERKN
Sbjct: 1 MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKN 60
Query: 61 SARKASIVKNLKDTLGIGKVKRKPSVPD-SASPADDSFVDPG----ERLYDLNMPAYVKF 115
S +K S+VKNLKDTLG+GK +RK S D S +P+ D+ +R+YDLN+PA+VKF
Sbjct: 61 SLKKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKF 120
Query: 116 NYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSL 175
Y+AEREDELSL+KG++V VMEKCSDGWWRGSYNGQ+GWFPSNYV EE D + L
Sbjct: 121 AYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFL 180
Query: 176 SEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKI 235
S + A ++N +VLHVVQ LYPFSS +EELNFEKG+ M+VIEKPENDPEWWKC+
Sbjct: 181 SLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNA 240
Query: 236 NGMVGLVPKNYVTVMQNNPLTSGLEPS-PPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEM 294
G VGLVPKNYV V+ + P L P+ PQ Y PS +G+FAG WYYG VTRHQAE
Sbjct: 241 RGQVGLVPKNYVVVLSDGP---ALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAEC 297
Query: 295 ALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVE 354
ALNERG EGDFLIRDSESSP+DFSVSLKA GKNKHFKVQL + VYCIGQR+F TM+ELVE
Sbjct: 298 ALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCIGQRRFHTMDELVE 357
Query: 355 HYKKAPIFTSEQGEKLYLVKHL 376
HYKKAPIFTSE GEKLYLV+ L
Sbjct: 358 HYKKAPIFTSEHGEKLYLVRAL 379
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 541 bits (1394), Expect = e-154
Identities = 264/382 (69%), Positives = 307/382 (80%), Gaps = 9/382 (2%)
Query: 1 MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKN 60
M EEV+V+AK+DY AQQ+QELDIKKNERLWLLDDSK+WWRVRN+ N+TG+VPSNYVERKN
Sbjct: 1 MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKN 60
Query: 61 SARKASIVKNLKDTLGIGKVKRKPSVPD-SASPADDSFVDPG----ERLYDLNMPAYVKF 115
S +K S+VKNLKDTLG+GK +RK S D S +P+ D+ +R+YDLN+PA+VKF
Sbjct: 61 SLKKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKF 120
Query: 116 NYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSL 175
Y+AEREDELSL+KG++V VMEKCSDGWWRGSYNGQ+GWFPSNYV EE D + L
Sbjct: 121 AYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFL 180
Query: 176 SEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKI 235
S + A ++N +VLHVVQ LYPFSS +EELNFEKG+ M+VIEKPENDPEWWKC+
Sbjct: 181 SLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNA 240
Query: 236 NGMVGLVPKNYVTVMQNNPLTSGLEPS-PPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEM 294
G VGLVPKNYV V+ + P L P+ PQ Y PS +G+FAG WYYG VTRHQAE
Sbjct: 241 RGQVGLVPKNYVVVLSDGP---ALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAEC 297
Query: 295 ALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVE 354
ALNERG EGDFLIRDSESSP+DFSVSLKA GKNKHFKVQL + VYCIGQR+F TM+ELVE
Sbjct: 298 ALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCIGQRRFHTMDELVE 357
Query: 355 HYKKAPIFTSEQGEKLYLVKHL 376
HYKKAPIFTSE GEKLYLV+ L
Sbjct: 358 HYKKAPIFTSEHGEKLYLVRAL 379
>gi|52630427 NCK adaptor protein 2 isoform B [Homo sapiens]
Length = 83
Score = 133 bits (335), Expect = 2e-31
Identities = 60/75 (80%), Positives = 70/75 (93%)
Query: 1 MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKN 60
M EEV+V+AK+DY AQQ+QELDIKKNERLWLLDDSK+WWRVRN+ N+TG+VPSNYVERKN
Sbjct: 1 MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKN 60
Query: 61 SARKASIVKNLKDTL 75
S +K S+VKNLKDTL
Sbjct: 61 SLKKGSLVKNLKDTL 75
Score = 35.8 bits (81), Expect = 0.065
Identities = 18/65 (27%), Positives = 34/65 (52%), Gaps = 5/65 (7%)
Query: 194 VVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNN 253
+V A + +++ D+EL+ +K + + +++ + WW+ R G VP NYV + N
Sbjct: 6 IVIAKWDYTAQQDQELDIKKNERLWLLDDSKT---WWRVRNAANRTGYVPSNYVE--RKN 60
Query: 254 PLTSG 258
L G
Sbjct: 61 SLKKG 65
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 106 bits (265), Expect = 3e-23
Identities = 75/266 (28%), Positives = 118/266 (44%), Gaps = 58/266 (21%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASI 67
+A + Y + ++ +L ++ + + + WW +K G PSNYV K+S +
Sbjct: 1008 IAMYTYESSEQGDLTFQQGDVILVTKKDGDWW-TGTVGDKAGVFPSNYVRLKDSEGSGTA 1066
Query: 68 VKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSL 127
K G + +KP + A V +Y A ++L+L
Sbjct: 1067 GKT-------GSLGKKPEI------------------------AQVIASYTATGPEQLTL 1095
Query: 128 IKGTKVIVMEKCSDGWWRGSYNG-----QVGWFPSNYVT--EEGDSPLGDHVGSLSEKLA 180
G +++ +K GWW G Q+GWFP+NYV G S + S LA
Sbjct: 1096 APGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALA 1155
Query: 181 AVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVG 240
AV V +Y +++ ND+EL F KG +++V+ K DP+WWK ++NG VG
Sbjct: 1156 AVCQ----------VIGMYDYTAQNDDELAFNKGQIINVLNK--EDPDWWK-GEVNGQVG 1202
Query: 241 LVPKNYVTVMQNNPLTSGLEPSPPQC 266
L P NYV LT+ ++PS C
Sbjct: 1203 LFPSNYV------KLTTDMDPSQQWC 1222
Score = 73.2 bits (178), Expect = 4e-13
Identities = 62/263 (23%), Positives = 114/263 (43%), Gaps = 41/263 (15%)
Query: 9 AKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIV 68
A + + A+++ L+ KN+ + +L+ WW + G+ P +YV+ + + S
Sbjct: 920 ALYPWRAKKDNHLNFNKNDVITVLEQQDMWW-FGEVQGQKGWFPKSYVKLISGPIRKS-- 976
Query: 69 KNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLI 128
++ G + S+ ASPA V E + + Y + + +L+
Sbjct: 977 ----TSMDSGSSESPASLKRVASPAAKPVVSGEEFI--------AMYTYESSEQGDLTFQ 1024
Query: 129 KGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYV---TEEGDSPLGDHVGSLSEKLAAVVNN 185
+G ++V +K D WW G+ + G FPSNYV EG G GSL +K
Sbjct: 1025 QGDVILVTKKDGD-WWTGTVGDKAGVFPSNYVRLKDSEGSGTAG-KTGSLGKK------- 1075
Query: 186 LNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWW----KCRKINGMVGL 241
+ Q + ++++ E+L G + ++ + +N WW + R +G
Sbjct: 1076 ------PEIAQVIASYTATGPEQLTLAPGQL--ILIRKKNPGGWWEGELQARGKKRQIGW 1127
Query: 242 VPKNYVTVMQNNPLTSGLEPSPP 264
P NYV ++ +P TS + P+ P
Sbjct: 1128 FPANYVKLL--SPGTSKITPTEP 1148
Score = 67.0 bits (162), Expect = 3e-11
Identities = 48/173 (27%), Positives = 81/173 (46%), Gaps = 21/173 (12%)
Query: 84 PSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGW 143
P+ +SP+ + GE++ L A + + A++++ L+ K + V+E+ D W
Sbjct: 895 PATATGSSPSP--VLGQGEKVEGLQAQAL--YPWRAKKDNHLNFNKNDVITVLEQ-QDMW 949
Query: 144 WRGSYNGQVGWFPSNYV---------TEEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLHV 194
W G GQ GWFP +YV + DS + SL + + +G+
Sbjct: 950 WFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEF-- 1007
Query: 195 VQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYV 247
A+Y + SS +L F++GDV+ V +K D +WW + G+ P NYV
Sbjct: 1008 -IAMYTYESSEQGDLTFQQGDVILVTKK---DGDWW-TGTVGDKAGVFPSNYV 1055
Score = 39.7 bits (91), Expect = 0.004
Identities = 29/128 (22%), Positives = 56/128 (43%), Gaps = 5/128 (3%)
Query: 138 KCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLHVVQA 197
K DG +G Q + +E P S +EK ++ +V++ +A
Sbjct: 689 KKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYY-RA 747
Query: 198 LYPFSSSNDEELNFEKGDVMDV----IEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNN 253
LYPF S + +E+ + GD++ V +++ + W ++ G G P NY + N
Sbjct: 748 LYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPEN 807
Query: 254 PLTSGLEP 261
+ + ++P
Sbjct: 808 EVPAPVKP 815
Score = 35.4 bits (80), Expect = 0.085
Identities = 18/64 (28%), Positives = 31/64 (48%), Gaps = 7/64 (10%)
Query: 124 ELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDS-------PLGDHVGSLS 176
++ ++KG V + GW G G+ GWFP+NY + ++ P+ D + +
Sbjct: 765 DIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPA 824
Query: 177 EKLA 180
KLA
Sbjct: 825 PKLA 828
Score = 35.0 bits (79), Expect = 0.11
Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 7 VVAKFDYVAQQEQELDIKKNERLWLLD-DSKSWWRVRNSMNKTGFVPSNYVE 57
V+ +DY AQ + EL K + + +L+ + WW+ + + G PSNYV+
Sbjct: 1160 VIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN-GQVGLFPSNYVK 1210
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 104 bits (260), Expect = 1e-22
Identities = 74/262 (28%), Positives = 117/262 (44%), Gaps = 58/262 (22%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASI 67
+A + Y + ++ +L ++ + + + WW +K G PSNYV K+S +
Sbjct: 1008 IAMYTYESSEQGDLTFQQGDVILVTKKDGDWW-TGTVGDKAGVFPSNYVRLKDSEGSGTA 1066
Query: 68 VKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSL 127
K G + +KP + A V +Y A ++L+L
Sbjct: 1067 GKT-------GSLGKKPEI------------------------AQVIASYTATGPEQLTL 1095
Query: 128 IKGTKVIVMEKCSDGWWRGSYNG-----QVGWFPSNYVT--EEGDSPLGDHVGSLSEKLA 180
G +++ +K GWW G Q+GWFP+NYV G S + S LA
Sbjct: 1096 APGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALA 1155
Query: 181 AVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVG 240
AV V +Y +++ ND+EL F KG +++V+ K DP+WWK ++NG VG
Sbjct: 1156 AVCQ----------VIGMYDYTAQNDDELAFNKGQIINVLNK--EDPDWWK-GEVNGQVG 1202
Query: 241 LVPKNYVTVMQNNPLTSGLEPS 262
L P NYV LT+ ++PS
Sbjct: 1203 LFPSNYV------KLTTDMDPS 1218
Score = 73.2 bits (178), Expect = 4e-13
Identities = 62/263 (23%), Positives = 114/263 (43%), Gaps = 41/263 (15%)
Query: 9 AKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIV 68
A + + A+++ L+ KN+ + +L+ WW + G+ P +YV+ + + S
Sbjct: 920 ALYPWRAKKDNHLNFNKNDVITVLEQQDMWW-FGEVQGQKGWFPKSYVKLISGPIRKS-- 976
Query: 69 KNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLI 128
++ G + S+ ASPA V E + + Y + + +L+
Sbjct: 977 ----TSMDSGSSESPASLKRVASPAAKPVVSGEEFI--------AMYTYESSEQGDLTFQ 1024
Query: 129 KGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYV---TEEGDSPLGDHVGSLSEKLAAVVNN 185
+G ++V +K D WW G+ + G FPSNYV EG G GSL +K
Sbjct: 1025 QGDVILVTKKDGD-WWTGTVGDKAGVFPSNYVRLKDSEGSGTAG-KTGSLGKK------- 1075
Query: 186 LNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWW----KCRKINGMVGL 241
+ Q + ++++ E+L G + ++ + +N WW + R +G
Sbjct: 1076 ------PEIAQVIASYTATGPEQLTLAPGQL--ILIRKKNPGGWWEGELQARGKKRQIGW 1127
Query: 242 VPKNYVTVMQNNPLTSGLEPSPP 264
P NYV ++ +P TS + P+ P
Sbjct: 1128 FPANYVKLL--SPGTSKITPTEP 1148
Score = 67.0 bits (162), Expect = 3e-11
Identities = 48/173 (27%), Positives = 81/173 (46%), Gaps = 21/173 (12%)
Query: 84 PSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGW 143
P+ +SP+ + GE++ L A + + A++++ L+ K + V+E+ D W
Sbjct: 895 PATATGSSPSP--VLGQGEKVEGLQAQAL--YPWRAKKDNHLNFNKNDVITVLEQ-QDMW 949
Query: 144 WRGSYNGQVGWFPSNYV---------TEEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLHV 194
W G GQ GWFP +YV + DS + SL + + +G+
Sbjct: 950 WFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEF-- 1007
Query: 195 VQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYV 247
A+Y + SS +L F++GDV+ V +K D +WW + G+ P NYV
Sbjct: 1008 -IAMYTYESSEQGDLTFQQGDVILVTKK---DGDWW-TGTVGDKAGVFPSNYV 1055
Score = 39.7 bits (91), Expect = 0.004
Identities = 29/128 (22%), Positives = 56/128 (43%), Gaps = 5/128 (3%)
Query: 138 KCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLHVVQA 197
K DG +G Q + +E P S +EK ++ +V++ +A
Sbjct: 689 KKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYY-RA 747
Query: 198 LYPFSSSNDEELNFEKGDVMDV----IEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNN 253
LYPF S + +E+ + GD++ V +++ + W ++ G G P NY + N
Sbjct: 748 LYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPEN 807
Query: 254 PLTSGLEP 261
+ + ++P
Sbjct: 808 EVPAPVKP 815
Score = 35.4 bits (80), Expect = 0.085
Identities = 18/64 (28%), Positives = 31/64 (48%), Gaps = 7/64 (10%)
Query: 124 ELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDS-------PLGDHVGSLS 176
++ ++KG V + GW G G+ GWFP+NY + ++ P+ D + +
Sbjct: 765 DIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPA 824
Query: 177 EKLA 180
KLA
Sbjct: 825 PKLA 828
Score = 35.0 bits (79), Expect = 0.11
Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 7 VVAKFDYVAQQEQELDIKKNERLWLLD-DSKSWWRVRNSMNKTGFVPSNYVE 57
V+ +DY AQ + EL K + + +L+ + WW+ + + G PSNYV+
Sbjct: 1160 VIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN-GQVGLFPSNYVK 1210
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 100 bits (249), Expect = 2e-21
Identities = 58/172 (33%), Positives = 100/172 (58%), Gaps = 33/172 (19%)
Query: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLT 256
A Y F ++ D+EL+F++GD++ V+ + E D W+K ++NG G +PKNY+
Sbjct: 5 AKYDFKATADDELSFKRGDILKVLNE-ECDQNWYKA-ELNGKDGFIPKNYI--------- 53
Query: 257 SGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPND 316
E P +PW++GK+ R +AE L+++ H+G FLIR+SES+P D
Sbjct: 54 ---EMKP----------------HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGD 94
Query: 317 FSVSLKAQGKNKHFKVQLKETV--YCIGQRKFSTMEELVEHYKKAPIFTSEQ 366
FS+S+K +HFKV L++ Y + KF+++ ELV++++ + ++Q
Sbjct: 95 FSLSVKFGNDVQHFKV-LRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQ 145
Score = 63.2 bits (152), Expect = 4e-10
Identities = 66/249 (26%), Positives = 105/249 (42%), Gaps = 39/249 (15%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLDDS--KSWWRVRNSMNKTGFVPSNYVERKNSARKA 65
+AK+D+ A + EL K+ + L +L++ ++W++ + K GF+P NY+E K
Sbjct: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELN-GKDGFIPKNYIEMK------ 56
Query: 66 SIVKNLKDTLGIGKVKR-KPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDE 124
GK+ R K S D +F+ ++ + A +
Sbjct: 57 ------PHPWFFGKIPRAKAEEMLSKQRHDGAFL--------------IRESESAPGDFS 96
Query: 125 LSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVN 184
LS+ G V + DG G Y V F N + E D V + +
Sbjct: 97 LSVKFGNDVQHFKVLRDG--AGKYFLWVVKF--NSLNELVDYHRSTSVSRNQQIFLRDIE 152
Query: 185 NLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPK 244
+ Q VQAL+ F D EL F +GD + V++ +DP WWK +G G+ P+
Sbjct: 153 QVP--QQPTYVQALFDFDPQEDGELGFRRGDFIHVMD--NSDPNWWK-GACHGQTGMFPR 207
Query: 245 NYVTVMQNN 253
NYVT + N
Sbjct: 208 NYVTPVNRN 216
Score = 44.3 bits (103), Expect = 2e-04
Identities = 19/53 (35%), Positives = 32/53 (60%), Gaps = 1/53 (1%)
Query: 109 MPAYVKFNYMAEREDELSLIKGTKVIVM-EKCSDGWWRGSYNGQVGWFPSNYV 160
M A K+++ A +DELS +G + V+ E+C W++ NG+ G+ P NY+
Sbjct: 1 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI 53
Score = 33.5 bits (75), Expect = 0.32
Identities = 17/54 (31%), Positives = 28/54 (51%)
Query: 7 VVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKN 60
V A FD+ Q++ EL ++ + + ++D+S W +TG P NYV N
Sbjct: 161 VQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVN 214
>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
Length = 217
Score = 100 bits (249), Expect = 2e-21
Identities = 60/172 (34%), Positives = 91/172 (52%), Gaps = 33/172 (19%)
Query: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLT 256
ALY F ++ +EL F KGD + ++ E+D W+K ++ G+ G +PKNY+ V +
Sbjct: 5 ALYSFQATESDELAFNKGDTLKILNM-EDDQNWYKA-ELRGVEGFIPKNYIRVKPH---- 58
Query: 257 SGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPND 316
PWY G+++R AE L +R H G FLIR+SESSP +
Sbjct: 59 ------------------------PWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGE 94
Query: 317 FSVSLKAQGKNKHFKVQLKET--VYCIGQRKFSTMEELVEHYKKAPIFTSEQ 366
FSVS+ + +HFKV L+E Y + + KF+++ ELV+ Y+ I Q
Sbjct: 95 FSVSVNYGDQVQHFKV-LREASGKYFLWEEKFNSLNELVDFYRTTTIAKKRQ 145
Score = 56.6 bits (135), Expect = 4e-08
Identities = 57/250 (22%), Positives = 101/250 (40%), Gaps = 51/250 (20%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLL--DDSKSWWRVRNSMNKTGFVPSNYVERKN----- 60
VA + + A + EL K + L +L +D ++W++ GF+P NY+ K
Sbjct: 4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAE-LRGVEGFIPKNYIRVKPHPWYS 62
Query: 61 ---SARKASIVKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNY 117
S + A + ++ LG ++ S P S + V+ G+++ + Y
Sbjct: 63 GRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVS----VNYGDQVQHFKVLREASGKY 118
Query: 118 MAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSE 177
E SL N V ++ + + ++ L D L
Sbjct: 119 FLWEEKFNSL---------------------NELVDFYRTTTIAKKRQIFLRDEEPLLKS 157
Query: 178 KLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKING 237
A QA + FS+ + +L+F +GD+++V+E+P DP WW+ R G
Sbjct: 158 PGACFA------------QAQFDFSAQDPSQLSFRRGDIIEVLERP--DPHWWRGRSC-G 202
Query: 238 MVGLVPKNYV 247
VG P++YV
Sbjct: 203 RVGFFPRSYV 212
Score = 35.0 bits (79), Expect = 0.11
Identities = 17/50 (34%), Positives = 29/50 (58%), Gaps = 2/50 (4%)
Query: 9 AKFDYVAQQEQELDIKKNERLWLLD-DSKSWWRVRNSMNKTGFVPSNYVE 57
A+FD+ AQ +L ++ + + +L+ WWR R S + GF P +YV+
Sbjct: 165 AQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGR-SCGRVGFFPRSYVQ 213
Score = 33.1 bits (74), Expect = 0.42
Identities = 19/73 (26%), Positives = 35/73 (47%), Gaps = 4/73 (5%)
Query: 109 MPAYVKFNYMAEREDELSLIKGTKVIVMEKCSD-GWWRGSYNGQVGWFPSNYVTEEGDSP 167
M + +++ A DEL+ KG + ++ D W++ G G+ P NY+ + P
Sbjct: 1 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVK---P 57
Query: 168 LGDHVGSLSEKLA 180
+ G +S +LA
Sbjct: 58 HPWYSGRISRQLA 70
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 97.8 bits (242), Expect = 1e-20
Identities = 70/264 (26%), Positives = 123/264 (46%), Gaps = 61/264 (23%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASI 67
+A + Y + + +L + E + + WW + +++G PSNYV+ K+ S
Sbjct: 960 IALYPYSSVEPGDLTFTEGEEILVTQKDGEWW-TGSIGDRSGIFPSNYVKPKDQESFGSA 1018
Query: 68 VKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSL 127
K+ G +KP + A V Y+A ++LSL
Sbjct: 1019 SKS-------GASNKKPEI------------------------AQVTSAYVASGSEQLSL 1047
Query: 128 IKGTKVIVMEKCSDGWWRGSYNG-----QVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAV 182
G +++++K + GWW+G Q GWFP+++V G S SE+
Sbjct: 1048 APGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPS---------SERATPA 1098
Query: 183 VNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLV 242
+ V V+ A+Y ++++N++EL+F KG +++V+ K +DP+WW+ +ING+ GL
Sbjct: 1099 FH-----PVCQVI-AMYDYAANNEDELSFSKGQLINVMNK--DDPDWWQ-GEINGVTGLF 1149
Query: 243 PKNYVTVMQNNPLTSGLEPSPPQC 266
P NYV +T+ +PS C
Sbjct: 1150 PSNYV------KMTTDSDPSQQWC 1167
Score = 65.9 bits (159), Expect = 6e-11
Identities = 46/143 (32%), Positives = 69/143 (48%), Gaps = 11/143 (7%)
Query: 108 NMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSP 167
N+ A ++ A++++ L+ K + V+E+ + WW G +G GWFP +YV P
Sbjct: 873 NLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVK---IIP 928
Query: 168 LGDHVGSLSEKLAAVVNNLNTGQVLHVVQ---ALYPFSSSNDEELNFEKGDVMDVIEKPE 224
+ E L A VN T V + ALYP+SS +L F +G+ + V +K
Sbjct: 929 GSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-- 986
Query: 225 NDPEWWKCRKINGMVGLVPKNYV 247
D EWW I G+ P NYV
Sbjct: 987 -DGEWW-TGSIGDRSGIFPSNYV 1007
Score = 57.8 bits (138), Expect = 2e-08
Identities = 49/193 (25%), Positives = 74/193 (38%), Gaps = 61/193 (31%)
Query: 115 FNYMAEREDELSLIKGTKVIVMEKC--SDGWWRGSYNGQVGWFPSNYV------------ 160
+ + A DE+S G + V EK GW GS+ G GWFP NYV
Sbjct: 739 YPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAV 798
Query: 161 ---------------TEEGDSPLGDH-----------------VGSLSEKLAAVVNNLNT 188
T PL + V + +K +A ++
Sbjct: 799 SPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSP 858
Query: 189 GQVLHV-----------VQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKING 237
G V + QAL +++ D LNF K D++ V+E+ EN WW +++G
Sbjct: 859 GSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN---WW-FGEVHG 914
Query: 238 MVGLVPKNYVTVM 250
G PK+YV ++
Sbjct: 915 GRGWFPKSYVKII 927
Score = 48.9 bits (115), Expect = 7e-06
Identities = 28/85 (32%), Positives = 40/85 (47%), Gaps = 1/85 (1%)
Query: 177 EKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKIN 236
+ L A T VL +ALYPF + N +E++F GD++ V EK +P W
Sbjct: 717 DTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEP-GWLYGSFQ 775
Query: 237 GMVGLVPKNYVTVMQNNPLTSGLEP 261
G G P NYV M ++ + P
Sbjct: 776 GNFGWFPCNYVEKMPSSENEKAVSP 800
Score = 38.1 bits (87), Expect = 0.013
Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 7 VVAKFDYVAQQEQELDIKKNERLWLLD-DSKSWWRVRNSMNKTGFVPSNYVE 57
V+A +DY A E EL K + + +++ D WW+ + TG PSNYV+
Sbjct: 1105 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEIN-GVTGLFPSNYVK 1155
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 97.8 bits (242), Expect = 1e-20
Identities = 70/264 (26%), Positives = 123/264 (46%), Gaps = 61/264 (23%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASI 67
+A + Y + + +L + E + + WW + +++G PSNYV+ K+ S
Sbjct: 987 IALYPYSSVEPGDLTFTEGEEILVTQKDGEWW-TGSIGDRSGIFPSNYVKPKDQESFGSA 1045
Query: 68 VKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSL 127
K+ G +KP + A V Y+A ++LSL
Sbjct: 1046 SKS-------GASNKKPEI------------------------AQVTSAYVASGSEQLSL 1074
Query: 128 IKGTKVIVMEKCSDGWWRGSYNG-----QVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAV 182
G +++++K + GWW+G Q GWFP+++V G S SE+
Sbjct: 1075 APGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPS---------SERATPA 1125
Query: 183 VNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLV 242
+ V V+ A+Y ++++N++EL+F KG +++V+ K +DP+WW+ +ING+ GL
Sbjct: 1126 FH-----PVCQVI-AMYDYAANNEDELSFSKGQLINVMNK--DDPDWWQ-GEINGVTGLF 1176
Query: 243 PKNYVTVMQNNPLTSGLEPSPPQC 266
P NYV +T+ +PS C
Sbjct: 1177 PSNYV------KMTTDSDPSQQWC 1194
Score = 65.9 bits (159), Expect = 6e-11
Identities = 46/143 (32%), Positives = 69/143 (48%), Gaps = 11/143 (7%)
Query: 108 NMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSP 167
N+ A ++ A++++ L+ K + V+E+ + WW G +G GWFP +YV P
Sbjct: 900 NLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVK---IIP 955
Query: 168 LGDHVGSLSEKLAAVVNNLNTGQVLHVVQ---ALYPFSSSNDEELNFEKGDVMDVIEKPE 224
+ E L A VN T V + ALYP+SS +L F +G+ + V +K
Sbjct: 956 GSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-- 1013
Query: 225 NDPEWWKCRKINGMVGLVPKNYV 247
D EWW I G+ P NYV
Sbjct: 1014 -DGEWW-TGSIGDRSGIFPSNYV 1034
Score = 57.8 bits (138), Expect = 2e-08
Identities = 49/193 (25%), Positives = 74/193 (38%), Gaps = 61/193 (31%)
Query: 115 FNYMAEREDELSLIKGTKVIVMEKC--SDGWWRGSYNGQVGWFPSNYV------------ 160
+ + A DE+S G + V EK GW GS+ G GWFP NYV
Sbjct: 766 YPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAV 825
Query: 161 ---------------TEEGDSPLGDH-----------------VGSLSEKLAAVVNNLNT 188
T PL + V + +K +A ++
Sbjct: 826 SPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSP 885
Query: 189 GQVLHV-----------VQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKING 237
G V + QAL +++ D LNF K D++ V+E+ EN WW +++G
Sbjct: 886 GSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN---WW-FGEVHG 941
Query: 238 MVGLVPKNYVTVM 250
G PK+YV ++
Sbjct: 942 GRGWFPKSYVKII 954
Score = 48.9 bits (115), Expect = 7e-06
Identities = 28/85 (32%), Positives = 40/85 (47%), Gaps = 1/85 (1%)
Query: 177 EKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKIN 236
+ L A T VL +ALYPF + N +E++F GD++ V EK +P W
Sbjct: 744 DTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEP-GWLYGSFQ 802
Query: 237 GMVGLVPKNYVTVMQNNPLTSGLEP 261
G G P NYV M ++ + P
Sbjct: 803 GNFGWFPCNYVEKMPSSENEKAVSP 827
Score = 38.1 bits (87), Expect = 0.013
Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 7 VVAKFDYVAQQEQELDIKKNERLWLLD-DSKSWWRVRNSMNKTGFVPSNYVE 57
V+A +DY A E EL K + + +++ D WW+ + TG PSNYV+
Sbjct: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEIN-GVTGLFPSNYVK 1182
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 97.8 bits (242), Expect = 1e-20
Identities = 70/264 (26%), Positives = 123/264 (46%), Gaps = 61/264 (23%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASI 67
+A + Y + + +L + E + + WW + +++G PSNYV+ K+ S
Sbjct: 987 IALYPYSSVEPGDLTFTEGEEILVTQKDGEWW-TGSIGDRSGIFPSNYVKPKDQESFGSA 1045
Query: 68 VKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSL 127
K+ G +KP + A V Y+A ++LSL
Sbjct: 1046 SKS-------GASNKKPEI------------------------AQVTSAYVASGSEQLSL 1074
Query: 128 IKGTKVIVMEKCSDGWWRGSYNG-----QVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAV 182
G +++++K + GWW+G Q GWFP+++V G S SE+
Sbjct: 1075 APGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPS---------SERATPA 1125
Query: 183 VNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLV 242
+ V V+ A+Y ++++N++EL+F KG +++V+ K +DP+WW+ +ING+ GL
Sbjct: 1126 FH-----PVCQVI-AMYDYAANNEDELSFSKGQLINVMNK--DDPDWWQ-GEINGVTGLF 1176
Query: 243 PKNYVTVMQNNPLTSGLEPSPPQC 266
P NYV +T+ +PS C
Sbjct: 1177 PSNYV------KMTTDSDPSQQWC 1194
Score = 65.9 bits (159), Expect = 6e-11
Identities = 46/143 (32%), Positives = 69/143 (48%), Gaps = 11/143 (7%)
Query: 108 NMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSP 167
N+ A ++ A++++ L+ K + V+E+ + WW G +G GWFP +YV P
Sbjct: 900 NLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVK---IIP 955
Query: 168 LGDHVGSLSEKLAAVVNNLNTGQVLHVVQ---ALYPFSSSNDEELNFEKGDVMDVIEKPE 224
+ E L A VN T V + ALYP+SS +L F +G+ + V +K
Sbjct: 956 GSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-- 1013
Query: 225 NDPEWWKCRKINGMVGLVPKNYV 247
D EWW I G+ P NYV
Sbjct: 1014 -DGEWW-TGSIGDRSGIFPSNYV 1034
Score = 57.8 bits (138), Expect = 2e-08
Identities = 49/193 (25%), Positives = 74/193 (38%), Gaps = 61/193 (31%)
Query: 115 FNYMAEREDELSLIKGTKVIVMEKC--SDGWWRGSYNGQVGWFPSNYV------------ 160
+ + A DE+S G + V EK GW GS+ G GWFP NYV
Sbjct: 766 YPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAV 825
Query: 161 ---------------TEEGDSPLGDH-----------------VGSLSEKLAAVVNNLNT 188
T PL + V + +K +A ++
Sbjct: 826 SPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSP 885
Query: 189 GQVLHV-----------VQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKING 237
G V + QAL +++ D LNF K D++ V+E+ EN WW +++G
Sbjct: 886 GSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN---WW-FGEVHG 941
Query: 238 MVGLVPKNYVTVM 250
G PK+YV ++
Sbjct: 942 GRGWFPKSYVKII 954
Score = 48.9 bits (115), Expect = 7e-06
Identities = 28/85 (32%), Positives = 40/85 (47%), Gaps = 1/85 (1%)
Query: 177 EKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKIN 236
+ L A T VL +ALYPF + N +E++F GD++ V EK +P W
Sbjct: 744 DTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEP-GWLYGSFQ 802
Query: 237 GMVGLVPKNYVTVMQNNPLTSGLEP 261
G G P NYV M ++ + P
Sbjct: 803 GNFGWFPCNYVEKMPSSENEKAVSP 827
Score = 38.1 bits (87), Expect = 0.013
Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 7 VVAKFDYVAQQEQELDIKKNERLWLLD-DSKSWWRVRNSMNKTGFVPSNYVE 57
V+A +DY A E EL K + + +++ D WW+ + TG PSNYV+
Sbjct: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEIN-GVTGLFPSNYVK 1182
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 82.8 bits (203), Expect = 5e-16
Identities = 66/244 (27%), Positives = 110/244 (45%), Gaps = 32/244 (13%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASI 67
VA+F+Y+ +Q+ EL + E + L + W +TG P N+VE +
Sbjct: 518 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSG- 576
Query: 68 VKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSL 127
N+ T KV K DS S + + + P E L+ ++ AE D+LS
Sbjct: 577 -ANVLST----KVPLKTKKEDSGSNSQVNSL-PAEWCEALH-------SFTAETSDDLSF 623
Query: 128 IKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLN 187
+G ++ ++E+ W RG + G FP+ +V P S+ LA V
Sbjct: 624 KRGDRIQILERLDSDWCRGRLQDREGIFPAVFV-----RPCPAEAKSM---LAIVPKG-- 673
Query: 188 TGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYV 247
+ALY F N++EL+F+ GD++ +E ++D W ++ G G+ PKNY+
Sbjct: 674 -----RKAKALYDFRGENEDELSFKAGDIITELESVDDD---WMSGELMGKSGIFPKNYI 725
Query: 248 TVMQ 251
+Q
Sbjct: 726 QFLQ 729
Score = 78.2 bits (191), Expect = 1e-14
Identities = 63/247 (25%), Positives = 109/247 (44%), Gaps = 39/247 (15%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASI 67
V D+ A+Q +L++ E ++LL+ + W N N+ G P+NY
Sbjct: 442 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANY------------ 489
Query: 68 VKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSL 127
VK + D G KR+ S G R +F Y+ E++DELS
Sbjct: 490 VKVIIDIPEGGNGKRE---------CVSSHCVKGSR-------CVARFEYIGEQKDELSF 533
Query: 128 IKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLN 187
+G +I+ E ++ W RG G+ G FP N+V D P LS K+ +
Sbjct: 534 SEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSG-ANVLSTKVPLKTKKED 592
Query: 188 TGQVLHV-------VQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVG 240
+G V +AL+ F++ ++L+F++GD + ++E+ ++D W ++ G
Sbjct: 593 SGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD---WCRGRLQDREG 649
Query: 241 LVPKNYV 247
+ P +V
Sbjct: 650 IFPAVFV 656
Score = 62.8 bits (151), Expect = 5e-10
Identities = 44/148 (29%), Positives = 77/148 (52%), Gaps = 12/148 (8%)
Query: 111 AYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGD 170
A V ++ AE+ D+L+L G V ++EK W+RG+ Q+G FP+NYV D P G
Sbjct: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 500
Query: 171 HVGSLSEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWW 230
+ K V ++ G A + + +EL+F +G+++ ++++ N E W
Sbjct: 501 -----NGKRECVSSHCVKGS---RCVARFEYIGEQKDELSFSEGEII-ILKEYVN--EEW 549
Query: 231 KCRKINGMVGLVPKNYVTVMQNNPLTSG 258
++ G G+ P N+V +++ P TSG
Sbjct: 550 ARGEVRGRTGIFPLNFVEPVEDYP-TSG 576
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 82.8 bits (203), Expect = 5e-16
Identities = 66/244 (27%), Positives = 110/244 (45%), Gaps = 32/244 (13%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASI 67
VA+F+Y+ +Q+ EL + E + L + W +TG P N+VE +
Sbjct: 554 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSG- 612
Query: 68 VKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSL 127
N+ T KV K DS S + + + P E L+ ++ AE D+LS
Sbjct: 613 -ANVLST----KVPLKTKKEDSGSNSQVNSL-PAEWCEALH-------SFTAETSDDLSF 659
Query: 128 IKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLN 187
+G ++ ++E+ W RG + G FP+ +V P S+ LA V
Sbjct: 660 KRGDRIQILERLDSDWCRGRLQDREGIFPAVFV-----RPCPAEAKSM---LAIVPKG-- 709
Query: 188 TGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYV 247
+ALY F N++EL+F+ GD++ +E ++D W ++ G G+ PKNY+
Sbjct: 710 -----RKAKALYDFRGENEDELSFKAGDIITELESVDDD---WMSGELMGKSGIFPKNYI 761
Query: 248 TVMQ 251
+Q
Sbjct: 762 QFLQ 765
Score = 78.2 bits (191), Expect = 1e-14
Identities = 63/247 (25%), Positives = 109/247 (44%), Gaps = 39/247 (15%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASI 67
V D+ A+Q +L++ E ++LL+ + W N N+ G P+NY
Sbjct: 478 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANY------------ 525
Query: 68 VKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSL 127
VK + D G KR+ S G R +F Y+ E++DELS
Sbjct: 526 VKVIIDIPEGGNGKRE---------CVSSHCVKGSR-------CVARFEYIGEQKDELSF 569
Query: 128 IKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLN 187
+G +I+ E ++ W RG G+ G FP N+V D P LS K+ +
Sbjct: 570 SEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSG-ANVLSTKVPLKTKKED 628
Query: 188 TGQVLHV-------VQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVG 240
+G V +AL+ F++ ++L+F++GD + ++E+ ++D W ++ G
Sbjct: 629 SGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD---WCRGRLQDREG 685
Query: 241 LVPKNYV 247
+ P +V
Sbjct: 686 IFPAVFV 692
Score = 62.8 bits (151), Expect = 5e-10
Identities = 44/148 (29%), Positives = 77/148 (52%), Gaps = 12/148 (8%)
Query: 111 AYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGD 170
A V ++ AE+ D+L+L G V ++EK W+RG+ Q+G FP+NYV D P G
Sbjct: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 536
Query: 171 HVGSLSEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWW 230
+ K V ++ G A + + +EL+F +G+++ ++++ N E W
Sbjct: 537 -----NGKRECVSSHCVKGS---RCVARFEYIGEQKDELSFSEGEII-ILKEYVN--EEW 585
Query: 231 KCRKINGMVGLVPKNYVTVMQNNPLTSG 258
++ G G+ P N+V +++ P TSG
Sbjct: 586 ARGEVRGRTGIFPLNFVEPVEDYP-TSG 612
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 82.8 bits (203), Expect = 5e-16
Identities = 66/244 (27%), Positives = 110/244 (45%), Gaps = 32/244 (13%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASI 67
VA+F+Y+ +Q+ EL + E + L + W +TG P N+VE +
Sbjct: 577 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGA 636
Query: 68 VKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSL 127
N+ T KV K DS S + + + P E L+ ++ AE D+LS
Sbjct: 637 --NVLST----KVPLKTKKEDSGSNSQVNSL-PAEWCEALH-------SFTAETSDDLSF 682
Query: 128 IKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLN 187
+G ++ ++E+ W RG + G FP+ +V P S+ LA V
Sbjct: 683 KRGDRIQILERLDSDWCRGRLQDREGIFPAVFV-----RPCPAEAKSM---LAIVPKG-- 732
Query: 188 TGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYV 247
+ALY F N++EL+F+ GD++ +E ++D W ++ G G+ PKNY+
Sbjct: 733 -----RKAKALYDFRGENEDELSFKAGDIITELESVDDD---WMSGELMGKSGIFPKNYI 784
Query: 248 TVMQ 251
+Q
Sbjct: 785 QFLQ 788
Score = 66.2 bits (160), Expect = 4e-11
Identities = 64/251 (25%), Positives = 114/251 (45%), Gaps = 36/251 (14%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASI 67
+A D V+Q EL K+ + L +L +++ + TG V + ++ I
Sbjct: 421 IANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMK---------I 471
Query: 68 VKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSL 127
+ L + L + +P+ P A DS L+D + AE+ D+L+L
Sbjct: 472 ITPLDEHL-----RSRPNDPSHAQKPVDSGAPHAVVLHD----------FPAEQVDDLNL 516
Query: 128 IKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLN 187
G V ++EK W+RG+ Q+G FP+NYV D P G + K V ++
Sbjct: 517 TSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG-----NGKRECVSSHCV 571
Query: 188 TGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYV 247
G A + + +EL+F +G+++ ++++ N E W ++ G G+ P N+V
Sbjct: 572 KGS---RCVARFEYIGEQKDELSFSEGEII-ILKEYVN--EEWARGEVRGRTGIFPLNFV 625
Query: 248 TVMQNNPLTSG 258
+++ P TSG
Sbjct: 626 EPVEDYP-TSG 635
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 81.6 bits (200), Expect = 1e-15
Identities = 55/162 (33%), Positives = 82/162 (50%), Gaps = 29/162 (17%)
Query: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLT 256
ALY F +S D L+ KG+ + V+ +N EW + R NG G VP NY+T P+
Sbjct: 99 ALYDFVASGDNTLSITKGEKLRVLGYNQNG-EWSEVRSKNGQ-GWVPSNYIT-----PVN 151
Query: 257 SGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPND 316
S + WY+G V+R AE L+ + G FL+R+SESSP
Sbjct: 152 S-------------------LEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQ 191
Query: 317 FSVSLKAQGKNKHFKVQLKE--TVYCIGQRKFSTMEELVEHY 356
S+SL+ +G+ H+++ VY + +FST+ ELV H+
Sbjct: 192 LSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHH 233
Score = 42.0 bits (97), Expect = 0.001
Identities = 26/61 (42%), Positives = 35/61 (57%), Gaps = 3/61 (4%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLL--DDSKSWWRVRNSMNKTGFVPSNYVERKNSARKA 65
VA +D+VA + L I K E+L +L + + W VR S N G+VPSNY+ NS K
Sbjct: 98 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVR-SKNGQGWVPSNYITPVNSLEKH 156
Query: 66 S 66
S
Sbjct: 157 S 157
Score = 38.1 bits (87), Expect = 0.013
Identities = 20/49 (40%), Positives = 31/49 (63%), Gaps = 3/49 (6%)
Query: 115 FNYMAEREDELSLIKGTKVIVMEKCSDGWWRG--SYNGQVGWFPSNYVT 161
++++A ++ LS+ KG K+ V+ +G W S NGQ GW PSNY+T
Sbjct: 101 YDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYIT 148
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 81.6 bits (200), Expect = 1e-15
Identities = 55/162 (33%), Positives = 82/162 (50%), Gaps = 29/162 (17%)
Query: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLT 256
ALY F +S D L+ KG+ + V+ +N EW + R NG G VP NY+T P+
Sbjct: 114 ALYDFVASGDNTLSITKGEKLRVLGYNQNG-EWSEVRSKNGQ-GWVPSNYIT-----PVN 166
Query: 257 SGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPND 316
S + WY+G V+R AE L+ + G FL+R+SESSP
Sbjct: 167 S-------------------LEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQ 206
Query: 317 FSVSLKAQGKNKHFKVQLKE--TVYCIGQRKFSTMEELVEHY 356
S+SL+ +G+ H+++ VY + +FST+ ELV H+
Sbjct: 207 LSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHH 248
Score = 42.0 bits (97), Expect = 0.001
Identities = 26/61 (42%), Positives = 35/61 (57%), Gaps = 3/61 (4%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLL--DDSKSWWRVRNSMNKTGFVPSNYVERKNSARKA 65
VA +D+VA + L I K E+L +L + + W VR S N G+VPSNY+ NS K
Sbjct: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVR-SKNGQGWVPSNYITPVNSLEKH 171
Query: 66 S 66
S
Sbjct: 172 S 172
Score = 38.1 bits (87), Expect = 0.013
Identities = 20/49 (40%), Positives = 31/49 (63%), Gaps = 3/49 (6%)
Query: 115 FNYMAEREDELSLIKGTKVIVMEKCSDGWWRG--SYNGQVGWFPSNYVT 161
++++A ++ LS+ KG K+ V+ +G W S NGQ GW PSNY+T
Sbjct: 116 YDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYIT 163
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 81.6 bits (200), Expect = 1e-15
Identities = 55/162 (33%), Positives = 82/162 (50%), Gaps = 29/162 (17%)
Query: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLT 256
ALY F +S D L+ KG+ + V+ +N EW + R NG G VP NY+T P+
Sbjct: 93 ALYDFVASGDNTLSITKGEKLRVLGYNQNG-EWSEVRSKNGQ-GWVPSNYIT-----PVN 145
Query: 257 SGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPND 316
S + WY+G V+R AE L+ + G FL+R+SESSP
Sbjct: 146 S-------------------LEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQ 185
Query: 317 FSVSLKAQGKNKHFKVQLKE--TVYCIGQRKFSTMEELVEHY 356
S+SL+ +G+ H+++ VY + +FST+ ELV H+
Sbjct: 186 LSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHH 227
Score = 42.0 bits (97), Expect = 0.001
Identities = 26/61 (42%), Positives = 35/61 (57%), Gaps = 3/61 (4%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLL--DDSKSWWRVRNSMNKTGFVPSNYVERKNSARKA 65
VA +D+VA + L I K E+L +L + + W VR S N G+VPSNY+ NS K
Sbjct: 92 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVR-SKNGQGWVPSNYITPVNSLEKH 150
Query: 66 S 66
S
Sbjct: 151 S 151
Score = 38.1 bits (87), Expect = 0.013
Identities = 20/49 (40%), Positives = 31/49 (63%), Gaps = 3/49 (6%)
Query: 115 FNYMAEREDELSLIKGTKVIVMEKCSDGWWRG--SYNGQVGWFPSNYVT 161
++++A ++ LS+ KG K+ V+ +G W S NGQ GW PSNY+T
Sbjct: 95 YDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYIT 142
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 81.6 bits (200), Expect = 1e-15
Identities = 55/162 (33%), Positives = 82/162 (50%), Gaps = 29/162 (17%)
Query: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLT 256
ALY F +S D L+ KG+ + V+ +N EW + R NG G VP NY+T P+
Sbjct: 99 ALYDFVASGDNTLSITKGEKLRVLGYNQNG-EWSEVRSKNGQ-GWVPSNYIT-----PVN 151
Query: 257 SGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPND 316
S + WY+G V+R AE L+ + G FL+R+SESSP
Sbjct: 152 S-------------------LEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQ 191
Query: 317 FSVSLKAQGKNKHFKVQLKE--TVYCIGQRKFSTMEELVEHY 356
S+SL+ +G+ H+++ VY + +FST+ ELV H+
Sbjct: 192 LSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHH 233
Score = 42.0 bits (97), Expect = 0.001
Identities = 26/61 (42%), Positives = 35/61 (57%), Gaps = 3/61 (4%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLL--DDSKSWWRVRNSMNKTGFVPSNYVERKNSARKA 65
VA +D+VA + L I K E+L +L + + W VR S N G+VPSNY+ NS K
Sbjct: 98 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVR-SKNGQGWVPSNYITPVNSLEKH 156
Query: 66 S 66
S
Sbjct: 157 S 157
Score = 38.1 bits (87), Expect = 0.013
Identities = 20/49 (40%), Positives = 31/49 (63%), Gaps = 3/49 (6%)
Query: 115 FNYMAEREDELSLIKGTKVIVMEKCSDGWWRG--SYNGQVGWFPSNYVT 161
++++A ++ LS+ KG K+ V+ +G W S NGQ GW PSNY+T
Sbjct: 101 YDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYIT 148
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 81.6 bits (200), Expect = 1e-15
Identities = 55/162 (33%), Positives = 82/162 (50%), Gaps = 29/162 (17%)
Query: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLT 256
ALY F +S D L+ KG+ + V+ +N EW + R NG G VP NY+T P+
Sbjct: 78 ALYDFVASGDNTLSITKGEKLRVLGYNQNG-EWSEVRSKNGQ-GWVPSNYIT-----PVN 130
Query: 257 SGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPND 316
S + WY+G V+R AE L+ + G FL+R+SESSP
Sbjct: 131 S-------------------LEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQ 170
Query: 317 FSVSLKAQGKNKHFKVQLKE--TVYCIGQRKFSTMEELVEHY 356
S+SL+ +G+ H+++ VY + +FST+ ELV H+
Sbjct: 171 LSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHH 212
Score = 42.0 bits (97), Expect = 0.001
Identities = 26/61 (42%), Positives = 35/61 (57%), Gaps = 3/61 (4%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLL--DDSKSWWRVRNSMNKTGFVPSNYVERKNSARKA 65
VA +D+VA + L I K E+L +L + + W VR S N G+VPSNY+ NS K
Sbjct: 77 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVR-SKNGQGWVPSNYITPVNSLEKH 135
Query: 66 S 66
S
Sbjct: 136 S 136
Score = 38.1 bits (87), Expect = 0.013
Identities = 20/49 (40%), Positives = 31/49 (63%), Gaps = 3/49 (6%)
Query: 115 FNYMAEREDELSLIKGTKVIVMEKCSDGWWRG--SYNGQVGWFPSNYVT 161
++++A ++ LS+ KG K+ V+ +G W S NGQ GW PSNY+T
Sbjct: 80 YDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYIT 127
>gi|193220941 hypothetical protein LOC400581 [Homo sapiens]
Length = 118
Score = 81.3 bits (199), Expect = 1e-15
Identities = 45/125 (36%), Positives = 66/125 (52%), Gaps = 30/125 (24%)
Query: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLT 256
ALY F ++ +EL F KGD + ++ E+D W+K ++ G+ G +PKNY+ V +
Sbjct: 5 ALYSFQATESDELAFNKGDTLKILNM-EDDQNWYKA-ELRGVEGFIPKNYIRVKPH---- 58
Query: 257 SGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPND 316
PWY G+++R AE L +R H G FLIR+SESSP +
Sbjct: 59 ------------------------PWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGE 94
Query: 317 FSVSL 321
FSVS+
Sbjct: 95 FSVSV 99
Score = 33.1 bits (74), Expect = 0.42
Identities = 19/73 (26%), Positives = 35/73 (47%), Gaps = 4/73 (5%)
Query: 109 MPAYVKFNYMAEREDELSLIKGTKVIVMEKCSD-GWWRGSYNGQVGWFPSNYVTEEGDSP 167
M + +++ A DEL+ KG + ++ D W++ G G+ P NY+ + P
Sbjct: 1 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVK---P 57
Query: 168 LGDHVGSLSEKLA 180
+ G +S +LA
Sbjct: 58 HPWYSGRISRQLA 70
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 80.1 bits (196), Expect = 3e-15
Identities = 53/162 (32%), Positives = 82/162 (50%), Gaps = 29/162 (17%)
Query: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLT 256
ALY F +S D L+ KG+ + V+ N EW + + NG G VP NY+T P+
Sbjct: 68 ALYDFVASGDNTLSITKGEKLRVLGYNHNG-EWCEAQTKNGQ-GWVPSNYIT-----PVN 120
Query: 257 SGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPND 316
S + WY+G V+R+ AE L+ G G FL+R+SESSP
Sbjct: 121 S-------------------LEKHSWYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQ 160
Query: 317 FSVSLKAQGKNKHFKVQLKE--TVYCIGQRKFSTMEELVEHY 356
S+SL+ +G+ H+++ +Y + +F+T+ ELV H+
Sbjct: 161 RSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHH 202
Score = 39.7 bits (91), Expect = 0.004
Identities = 23/60 (38%), Positives = 32/60 (53%), Gaps = 1/60 (1%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLD-DSKSWWRVRNSMNKTGFVPSNYVERKNSARKAS 66
VA +D+VA + L I K E+L +L + W + N G+VPSNY+ NS K S
Sbjct: 67 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHS 126
Score = 36.6 bits (83), Expect = 0.038
Identities = 19/49 (38%), Positives = 31/49 (63%), Gaps = 3/49 (6%)
Query: 115 FNYMAEREDELSLIKGTKVIVMEKCSDGWW--RGSYNGQVGWFPSNYVT 161
++++A ++ LS+ KG K+ V+ +G W + NGQ GW PSNY+T
Sbjct: 70 YDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GWVPSNYIT 117
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 80.1 bits (196), Expect = 3e-15
Identities = 53/162 (32%), Positives = 82/162 (50%), Gaps = 29/162 (17%)
Query: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLT 256
ALY F +S D L+ KG+ + V+ N EW + + NG G VP NY+T P+
Sbjct: 87 ALYDFVASGDNTLSITKGEKLRVLGYNHNG-EWCEAQTKNGQ-GWVPSNYIT-----PVN 139
Query: 257 SGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPND 316
S + WY+G V+R+ AE L+ G G FL+R+SESSP
Sbjct: 140 S-------------------LEKHSWYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQ 179
Query: 317 FSVSLKAQGKNKHFKVQLKE--TVYCIGQRKFSTMEELVEHY 356
S+SL+ +G+ H+++ +Y + +F+T+ ELV H+
Sbjct: 180 RSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHH 221
Score = 39.7 bits (91), Expect = 0.004
Identities = 23/60 (38%), Positives = 32/60 (53%), Gaps = 1/60 (1%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLD-DSKSWWRVRNSMNKTGFVPSNYVERKNSARKAS 66
VA +D+VA + L I K E+L +L + W + N G+VPSNY+ NS K S
Sbjct: 86 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHS 145
Score = 36.6 bits (83), Expect = 0.038
Identities = 19/49 (38%), Positives = 31/49 (63%), Gaps = 3/49 (6%)
Query: 115 FNYMAEREDELSLIKGTKVIVMEKCSDGWW--RGSYNGQVGWFPSNYVT 161
++++A ++ LS+ KG K+ V+ +G W + NGQ GW PSNY+T
Sbjct: 89 YDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GWVPSNYIT 136
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 80.1 bits (196), Expect = 3e-15
Identities = 48/161 (29%), Positives = 82/161 (50%), Gaps = 21/161 (13%)
Query: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLT 256
A Y F + +++L F KGDV+ ++ + DP W+K + G G++P NYV + +
Sbjct: 16 AKYNFHGTAEQDLPFCKGDVLTIVAVTK-DPNWYKAKNKVGREGIIPANYV--QKREGVK 72
Query: 257 SGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPND 316
+G K + PW++GK+TR QAE L G FL+R+S + P D
Sbjct: 73 AGT----------------KLSLMPWFHGKITREQAERLLYPP-ETGLFLVRESTNYPGD 115
Query: 317 FSVSLKAQGKNKHFKVQLKETVYCIGQR-KFSTMEELVEHY 356
+++ + GK +H+++ + I + F + +LVEHY
Sbjct: 116 YTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHY 156
Score = 39.7 bits (91), Expect = 0.004
Identities = 15/58 (25%), Positives = 36/58 (62%), Gaps = 2/58 (3%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLDDSK--SWWRVRNSMNKTGFVPSNYVERKNSAR 63
+AK+++ EQ+L K + L ++ +K +W++ +N + + G +P+NYV+++ +
Sbjct: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVK 72
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 80.1 bits (196), Expect = 3e-15
Identities = 48/161 (29%), Positives = 82/161 (50%), Gaps = 21/161 (13%)
Query: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLT 256
A Y F + +++L F KGDV+ ++ + DP W+K + G G++P NYV + +
Sbjct: 16 AKYNFHGTAEQDLPFCKGDVLTIVAVTK-DPNWYKAKNKVGREGIIPANYV--QKREGVK 72
Query: 257 SGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPND 316
+G K + PW++GK+TR QAE L G FL+R+S + P D
Sbjct: 73 AGT----------------KLSLMPWFHGKITREQAERLLYPP-ETGLFLVRESTNYPGD 115
Query: 317 FSVSLKAQGKNKHFKVQLKETVYCIGQR-KFSTMEELVEHY 356
+++ + GK +H+++ + I + F + +LVEHY
Sbjct: 116 YTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHY 156
Score = 39.7 bits (91), Expect = 0.004
Identities = 15/58 (25%), Positives = 36/58 (62%), Gaps = 2/58 (3%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLDDSK--SWWRVRNSMNKTGFVPSNYVERKNSAR 63
+AK+++ EQ+L K + L ++ +K +W++ +N + + G +P+NYV+++ +
Sbjct: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVK 72
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 80.1 bits (196), Expect = 3e-15
Identities = 58/202 (28%), Positives = 94/202 (46%), Gaps = 37/202 (18%)
Query: 164 GDSPLGDHVGSLSEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKP 223
G +P G S S ++ L G + V ALY + + E+L+F+KG+ +I
Sbjct: 67 GVTPFGGASSSFSVVPSSYPAGLTGGVTIFV--ALYDYEARTTEDLSFKKGERFQIINNT 124
Query: 224 ENDPEWWKCRKI-NGMVGLVPKNYVTVMQNNPLTSGLEPSPPQCDYIRPSLTGKFAGNPW 282
E D WW+ R I G G +P NYV + W
Sbjct: 125 EGD--WWEARSIATGKNGYIPSNYVAPADS------------------------IQAEEW 158
Query: 283 YYGKVTRHQAE-MALNERGHEGDFLIRDSESSPNDFSVSLK----AQGKN-KHFKVQLKE 336
Y+GK+ R AE + LN G FL+R+SE++ +S+S++ +G N KH+K++ +
Sbjct: 159 YFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLD 218
Query: 337 T--VYCIGQRKFSTMEELVEHY 356
Y + +F T+++LV+HY
Sbjct: 219 NGGYYITTRAQFDTLQKLVKHY 240
Score = 46.6 bits (109), Expect = 4e-05
Identities = 21/58 (36%), Positives = 37/58 (63%), Gaps = 2/58 (3%)
Query: 6 VVVAKFDYVAQQEQELDIKKNERLWLLDDSKS-WWRVRN-SMNKTGFVPSNYVERKNS 61
+ VA +DY A+ ++L KK ER ++++++ WW R+ + K G++PSNYV +S
Sbjct: 95 IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADS 152
Score = 35.0 bits (79), Expect = 0.11
Identities = 16/48 (33%), Positives = 25/48 (52%), Gaps = 2/48 (4%)
Query: 115 FNYMAEREDELSLIKGTKVIVMEKCSDGWW--RGSYNGQVGWFPSNYV 160
++Y A ++LS KG + ++ WW R G+ G+ PSNYV
Sbjct: 100 YDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYV 147
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 77.8 bits (190), Expect = 1e-14
Identities = 48/171 (28%), Positives = 86/171 (50%), Gaps = 35/171 (20%)
Query: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKIN-GMVGLVPKNYVTVMQNNPL 255
ALY + S + +L+F+KG+ + ++ E D WW ++ G G +P NYV
Sbjct: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGD--WWLAHSLSTGQTGYIPSNYVA------- 141
Query: 256 TSGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAE-MALNERGHEGDFLIRDSESSP 314
PS WY+GK+TR ++E + LN G FL+R+SE++
Sbjct: 142 -----PS------------DSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTK 184
Query: 315 NDFSVSL----KAQGKN-KHFKVQLKET--VYCIGQRKFSTMEELVEHYKK 358
+ +S+ A+G N KH+K++ ++ Y + +F+++++LV +Y K
Sbjct: 185 GAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSK 235
Score = 46.2 bits (108), Expect = 5e-05
Identities = 22/56 (39%), Positives = 37/56 (66%), Gaps = 2/56 (3%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLDDSK-SWWRVRN-SMNKTGFVPSNYVERKNS 61
VA +DY ++ E +L KK ERL ++++++ WW + S +TG++PSNYV +S
Sbjct: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDS 145
Score = 36.6 bits (83), Expect = 0.038
Identities = 16/48 (33%), Positives = 25/48 (52%), Gaps = 2/48 (4%)
Query: 115 FNYMAEREDELSLIKGTKVIVMEKCSDGWW--RGSYNGQVGWFPSNYV 160
++Y + E +LS KG ++ ++ WW GQ G+ PSNYV
Sbjct: 93 YDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 77.8 bits (190), Expect = 1e-14
Identities = 48/171 (28%), Positives = 86/171 (50%), Gaps = 35/171 (20%)
Query: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKIN-GMVGLVPKNYVTVMQNNPL 255
ALY + S + +L+F+KG+ + ++ E D WW ++ G G +P NYV
Sbjct: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGD--WWLAHSLSTGQTGYIPSNYVA------- 141
Query: 256 TSGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAE-MALNERGHEGDFLIRDSESSP 314
PS WY+GK+TR ++E + LN G FL+R+SE++
Sbjct: 142 -----PS------------DSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTK 184
Query: 315 NDFSVSL----KAQGKN-KHFKVQLKET--VYCIGQRKFSTMEELVEHYKK 358
+ +S+ A+G N KH+K++ ++ Y + +F+++++LV +Y K
Sbjct: 185 GAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSK 235
Score = 46.2 bits (108), Expect = 5e-05
Identities = 22/56 (39%), Positives = 37/56 (66%), Gaps = 2/56 (3%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLDDSK-SWWRVRN-SMNKTGFVPSNYVERKNS 61
VA +DY ++ E +L KK ERL ++++++ WW + S +TG++PSNYV +S
Sbjct: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDS 145
Score = 36.6 bits (83), Expect = 0.038
Identities = 16/48 (33%), Positives = 25/48 (52%), Gaps = 2/48 (4%)
Query: 115 FNYMAEREDELSLIKGTKVIVMEKCSDGWW--RGSYNGQVGWFPSNYV 160
++Y + E +LS KG ++ ++ WW GQ G+ PSNYV
Sbjct: 93 YDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 76.6 bits (187), Expect = 3e-14
Identities = 50/149 (33%), Positives = 77/149 (51%), Gaps = 15/149 (10%)
Query: 113 VKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYV--TEEGDSPLGD 170
V F+Y E+ DEL L G V ++++ DGWW G NGQ+G FPSN+V + G LG+
Sbjct: 90 VNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGN 149
Query: 171 -HVGSLS------EKLAAVV-----NNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMD 218
+ S+S KL+++ + L T V + L+ + +EL +GDV+
Sbjct: 150 PDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVK 209
Query: 219 VIEKPENDPEWWKCRKINGMVGLVPKNYV 247
V+ K D WW+ + G G+ P N+V
Sbjct: 210 VLSKTTEDKGWWE-GECQGRRGVFPDNFV 237
Score = 62.0 bits (149), Expect = 8e-10
Identities = 46/154 (29%), Positives = 74/154 (48%), Gaps = 12/154 (7%)
Query: 11 FDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIVKN 70
F Y +Q EL ++ E + ++ + + W + + G PSN+VE +S +
Sbjct: 92 FSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPS---LG 148
Query: 71 LKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAY--VKFNYMAEREDELSLI 128
D + ++P P +S A DS P + L ++ P V F+Y E DEL+L
Sbjct: 149 NPDMPSVSPGPQRP--PKLSSLAYDS---PPDYLQTVSHPEVYRVLFDYQPEAPDELALR 203
Query: 129 KGTKVIVMEKCSD--GWWRGSYNGQVGWFPSNYV 160
+G V V+ K ++ GWW G G+ G FP N+V
Sbjct: 204 RGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFV 237
Score = 59.3 bits (142), Expect = 5e-09
Identities = 41/156 (26%), Positives = 71/156 (45%), Gaps = 4/156 (2%)
Query: 109 MPAYVKFNYMAEREDELSLIKGTKVIVMEKC-SDGWWRGSYNGQVGWFPSNYVTEEGDSP 167
M V Y A++EDELSL G V + + GW RG + G+ G FP V E ++
Sbjct: 1 MEVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETL 60
Query: 168 LGDHVGSLSEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDP 227
G + + + + +S +EL + G+++++I++ E+
Sbjct: 61 RGSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDG- 119
Query: 228 EWWKCRKINGMVGLVPKNYVTVMQNNPLTSGLEPSP 263
WW +K NG +G P N+V ++ + P + G P
Sbjct: 120 -WWLGKK-NGQLGAFPSNFVELLDSGPPSLGNPDMP 153
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 76.6 bits (187), Expect = 3e-14
Identities = 51/180 (28%), Positives = 88/180 (48%), Gaps = 37/180 (20%)
Query: 188 TGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKI-NGMVGLVPKNY 246
TG L V ALY + + +++L+F KG+ ++ E D WW+ R + G G +P NY
Sbjct: 82 TGVTLFV--ALYDYEARTEDDLSFHKGEKFQILNSSEGD--WWEARSLTTGETGYIPSNY 137
Query: 247 VTVMQNNPLTSGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGH-EGDF 305
V + + WY+GK+ R AE L G+ G F
Sbjct: 138 VAPVDS------------------------IQAEEWYFGKLGRKDAERQLLSFGNPRGTF 173
Query: 306 LIRDSESSPNDFSVSLK----AQGKN-KHFKVQLKET--VYCIGQRKFSTMEELVEHYKK 358
LIR+SE++ +S+S++ +G + KH+K++ + Y + +F T+++LV+HY +
Sbjct: 174 LIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSE 233
Score = 45.4 bits (106), Expect = 8e-05
Identities = 21/51 (41%), Positives = 33/51 (64%), Gaps = 2/51 (3%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLDDSKS-WWRVRN-SMNKTGFVPSNYV 56
VA +DY A+ E +L K E+ +L+ S+ WW R+ + +TG++PSNYV
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYV 138
Score = 42.0 bits (97), Expect = 0.001
Identities = 19/48 (39%), Positives = 26/48 (54%), Gaps = 2/48 (4%)
Query: 115 FNYMAEREDELSLIKGTKVIVMEKCSDGWW--RGSYNGQVGWFPSNYV 160
++Y A ED+LS KG K ++ WW R G+ G+ PSNYV
Sbjct: 91 YDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYV 138
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 76.6 bits (187), Expect = 3e-14
Identities = 51/180 (28%), Positives = 88/180 (48%), Gaps = 37/180 (20%)
Query: 188 TGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKI-NGMVGLVPKNY 246
TG L V ALY + + +++L+F KG+ ++ E D WW+ R + G G +P NY
Sbjct: 82 TGVTLFV--ALYDYEARTEDDLSFHKGEKFQILNSSEGD--WWEARSLTTGETGYIPSNY 137
Query: 247 VTVMQNNPLTSGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGH-EGDF 305
V + + WY+GK+ R AE L G+ G F
Sbjct: 138 VAPVDS------------------------IQAEEWYFGKLGRKDAERQLLSFGNPRGTF 173
Query: 306 LIRDSESSPNDFSVSLK----AQGKN-KHFKVQLKET--VYCIGQRKFSTMEELVEHYKK 358
LIR+SE++ +S+S++ +G + KH+K++ + Y + +F T+++LV+HY +
Sbjct: 174 LIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSE 233
Score = 45.4 bits (106), Expect = 8e-05
Identities = 21/51 (41%), Positives = 33/51 (64%), Gaps = 2/51 (3%)
Query: 8 VAKFDYVAQQEQELDIKKNERLWLLDDSKS-WWRVRN-SMNKTGFVPSNYV 56
VA +DY A+ E +L K E+ +L+ S+ WW R+ + +TG++PSNYV
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYV 138
Score = 42.0 bits (97), Expect = 0.001
Identities = 19/48 (39%), Positives = 26/48 (54%), Gaps = 2/48 (4%)
Query: 115 FNYMAEREDELSLIKGTKVIVMEKCSDGWW--RGSYNGQVGWFPSNYV 160
++Y A ED+LS KG K ++ WW R G+ G+ PSNYV
Sbjct: 91 YDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYV 138
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,947,398
Number of Sequences: 37866
Number of extensions: 699149
Number of successful extensions: 2825
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 269
Number of HSP's successfully gapped in prelim test: 104
Number of HSP's that attempted gapping in prelim test: 1557
Number of HSP's gapped (non-prelim): 890
length of query: 377
length of database: 18,247,518
effective HSP length: 104
effective length of query: 273
effective length of database: 14,309,454
effective search space: 3906480942
effective search space used: 3906480942
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.