BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [Homo sapiens] (1265 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [... 2614 0.0 gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [... 2544 0.0 gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens] 1116 0.0 gi|157168349 F-box and leucine-rich repeat protein 19 [Homo sapi... 594 e-169 gi|32698700 PHD finger protein 8 [Homo sapiens] 291 3e-78 gi|90093355 jumonji C domain containing histone demethylase 1 ho... 274 3e-73 gi|117190342 PHD finger protein 2 [Homo sapiens] 248 3e-65 gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens] 78 6e-14 gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens] 71 7e-12 gi|156142182 CXXC finger 1 (PHD domain) isoform 1 [Homo sapiens] 67 1e-10 gi|156142180 CXXC finger 1 (PHD domain) isoform 2 [Homo sapiens] 67 1e-10 gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens] 66 2e-10 gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens] 64 1e-09 gi|195927037 DNA (cytosine-5-)-methyltransferase 1 isoform a [Ho... 62 3e-09 gi|4503351 DNA (cytosine-5-)-methyltransferase 1 isoform b [Homo... 62 3e-09 gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens] 60 2e-08 gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 59 3e-08 gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2 ... 59 4e-08 gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1 ... 59 4e-08 gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo ... 57 9e-08 gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo ... 57 9e-08 gi|21464115 methyl-CpG binding domain protein 1 isoform 2 [Homo ... 55 4e-07 gi|21464119 methyl-CpG binding domain protein 1 isoform PCM1 [Ho... 55 4e-07 gi|21464117 methyl-CpG binding domain protein 1 isoform 1 [Homo ... 55 4e-07 gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 55 6e-07 gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 54 7e-07 gi|55741709 RNA binding motif protein 25 [Homo sapiens] 54 1e-06 gi|148746195 trichohyalin [Homo sapiens] 54 1e-06 gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 52 5e-06 gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 51 6e-06 >gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [Homo sapiens] Length = 1265 Score = 2614 bits (6775), Expect = 0.0 Identities = 1265/1265 (100%), Positives = 1265/1265 (100%) Query: 1 MEAEKDSGRRLRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKD 60 MEAEKDSGRRLRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKD Sbjct: 1 MEAEKDSGRRLRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKD 60 Query: 61 FNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEM 120 FNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEM Sbjct: 61 FNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEM 120 Query: 121 SMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQ 180 SMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQ Sbjct: 121 SMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQ 180 Query: 181 TEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNL 240 TEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNL Sbjct: 181 TEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNL 240 Query: 241 ALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILH 300 ALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILH Sbjct: 241 ALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILH 300 Query: 301 SFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLI 360 SFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLI Sbjct: 301 SFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLI 360 Query: 361 DAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPS 420 DAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPS Sbjct: 361 DAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPS 420 Query: 421 EDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTE 480 EDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTE Sbjct: 421 EDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTE 480 Query: 481 FELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVT 540 FELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVT Sbjct: 481 FELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVT 540 Query: 541 WPKKTPKNRAVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCK 600 WPKKTPKNRAVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCK Sbjct: 541 WPKKTPKNRAVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCK 600 Query: 601 DMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSIC 660 DMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSIC Sbjct: 601 DMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSIC 660 Query: 661 NEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQ 720 NEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQ Sbjct: 661 NEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQ 720 Query: 721 KMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQE 780 KMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQE Sbjct: 721 KMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQE 780 Query: 781 LSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDH 840 LSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDH Sbjct: 781 LSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDH 840 Query: 841 SRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANEN 900 SRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANEN Sbjct: 841 SRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANEN 900 Query: 901 QQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPS 960 QQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPS Sbjct: 901 QQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPS 960 Query: 961 VSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCMRVC 1020 VSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCMRVC Sbjct: 961 VSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCMRVC 1020 Query: 1021 RTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLP 1080 RTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLP Sbjct: 1021 RTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLP 1080 Query: 1081 GLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNR 1140 GLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNR Sbjct: 1081 GLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNR 1140 Query: 1141 SKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDS 1200 SKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDS Sbjct: 1141 SKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDS 1200 Query: 1201 LTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSSFQGRSCSTT 1260 LTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSSFQGRSCSTT Sbjct: 1201 LTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSSFQGRSCSTT 1260 Query: 1261 RLGDE 1265 RLGDE Sbjct: 1261 RLGDE 1265 >gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [Homo sapiens] Length = 1336 Score = 2544 bits (6593), Expect = 0.0 Identities = 1239/1277 (97%), Positives = 1239/1277 (97%), Gaps = 38/1277 (2%) Query: 12 RPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREAL 71 RPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREAL Sbjct: 43 RPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREAL 102 Query: 72 RVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYET 131 RVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYET Sbjct: 103 RVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYET 162 Query: 132 PEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMK 191 PEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMK Sbjct: 163 PEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMK 222 Query: 192 YPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGK 251 YPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGK Sbjct: 223 YPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGK 282 Query: 252 QSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIY 311 QSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIY Sbjct: 283 QSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIY 342 Query: 312 EIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGF 371 EIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGF Sbjct: 343 EIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGF 402 Query: 372 SSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPK 431 SSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPK Sbjct: 403 SSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPK 462 Query: 432 APALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVE 491 APALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVE Sbjct: 463 APALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVE 522 Query: 492 KLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAV 551 KLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAV Sbjct: 523 KLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAV 582 Query: 552 GRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRM 611 GRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRM Sbjct: 583 GRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRM 642 Query: 612 KQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKI 671 KQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKI Sbjct: 643 KQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKI 702 Query: 672 KESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQE 731 KESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQE Sbjct: 703 KESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQE 762 Query: 732 PAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKR----- 786 PAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKR Sbjct: 763 PAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRASSLQ 822 Query: 787 ---------------------------------LKPGKEDKLFRKKRRSWKNAEDRMALA 813 LKPGKEDKLFRKKRRSWKNAEDRMALA Sbjct: 823 TSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRMALA 882 Query: 814 NKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLP 873 NKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLP Sbjct: 883 NKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLP 942 Query: 874 NKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLN 933 NKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLN Sbjct: 943 NKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLN 1002 Query: 934 GTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAA 993 GTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAA Sbjct: 1003 GTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAA 1062 Query: 994 HVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGII 1053 HVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGII Sbjct: 1063 HVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGII 1122 Query: 1054 RRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQW 1113 RRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQW Sbjct: 1123 RRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQW 1182 Query: 1114 VEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSK 1173 VEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSK Sbjct: 1183 VEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSK 1242 Query: 1174 LHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRY 1233 LHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRY Sbjct: 1243 LHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRY 1302 Query: 1234 CKQVTKEGCEQFIAEMS 1250 CKQVTKEGCEQFIAEMS Sbjct: 1303 CKQVTKEGCEQFIAEMS 1319 >gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens] Length = 1162 Score = 1116 bits (2886), Expect = 0.0 Identities = 631/1289 (48%), Positives = 803/1289 (62%), Gaps = 183/1289 (14%) Query: 1 MEAEKDSGR---RLRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAME 57 ME E++ R RLR R+RY E++ +SD +EI R F LEEKL + Y +FV ME Sbjct: 1 MEPEEERIRYSQRLRGTMRRRY-EDDGISD-DEIEGKRTFDLEEKLHTNKYNANFVTFME 58 Query: 58 GKDFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKG 117 GKDFN EY+QR LR PLIF+ DGLGIKMPDPDFTV DVK+ VGSRR+VDVMDVNTQKG Sbjct: 59 GKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKG 118 Query: 118 TEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLK 177 EM+M+Q+ RYYETPE +R+KLYNVISLEFSHT+LE++V+RP+ VD +DWVDNMWP+HLK Sbjct: 119 IEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLK 178 Query: 178 EKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTL 237 E QTE+TNAI EM+YPKV+KYCLMSV+GC+TDFH+DFGGTSVWYH+ +GGK+FWLIPPT Sbjct: 179 ESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTA 238 Query: 238 HNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGN 297 HNL LYE W+LSGKQ DIFLGDRV CQRIELKQGYTF IPSGWIHAVYTP D+LVFGGN Sbjct: 239 HNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGN 298 Query: 298 ILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRES 357 LHSFN+PMQL+IY IEDRTRV KFRYPFYYEMCWYVLERYVYC+T RSHLT+E+Q+ES Sbjct: 299 FLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKES 358 Query: 358 MLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTS 417 + +D ++G S + +EEA D++P+ + R P +G Sbjct: 359 LSMDL----ELNGLESGNG---DEEAVDREPRRLSSR------RSVLTSPVANGVNL--- 402 Query: 418 TPSEDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTH 477 D + LGK ++ L LK+TL+ +S S P +P + + H Sbjct: 403 ----DYDGLGKTCRS--LPSLKKTLAGDSSSDC-SRGSHNGQVWDPQCAPRKD---RQVH 452 Query: 478 LTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVP 537 LT FEL+GL+ LV+KLESLP +KKCVP GIED AL+ VK +L+E A+ DP LA+TGVP Sbjct: 453 LTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVP 512 Query: 538 VVTWPKKTPKNRAVGRPKGKLGPASAVK---------------LAANRTTAGARRRRTRC 582 +V WPK+ K + RPK ++ K AA+ +GARRRR RC Sbjct: 513 IVQWPKRD-KLKFPTRPKVRVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARRRRVRC 571 Query: 583 RKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDT 642 RKC+AC++ ECG CH+C+DMKKFGGPGRMKQSC++RQC+AP LPH+ Sbjct: 572 RKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVT------------ 619 Query: 643 VEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKR 702 CS+C E+ E +L C C + H G Q Sbjct: 620 --------------CSLCGEVDQ------NEETQDFEKKLMECCICNEIVHPGCL--QMD 657 Query: 703 GPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRR 762 G G LL E+ N C E P+ ++ S+K Sbjct: 658 GEG----------LLNEELPN---------------CWECPKCYQEDSSEKA-------- 684 Query: 763 KSDDVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQ 822 +K++ E +E K L+P + ++PL Sbjct: 685 -------QKRKMEESDEEAVQAKVLRP--------------------LRSCDEPLTPPPH 717 Query: 823 EPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELS 882 P L SSP AGPS + +E+ K ++L R Sbjct: 718 SPTSMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFK----------RRQLLR--- 764 Query: 883 KELNHEIQRTENSLANENQQPIKSEPE-SEGEEPK-RPPGICERPHRFSKGLNGTPRELR 940 +Q TE ++ E + + E SE E+ K R + R +K L+GT + Sbjct: 765 ------LQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPK 818 Query: 941 HQL----GPSLRSPPRVISRPPPSVSPPKCIQM--------ERHVIRPPPISPPPDSLPL 988 Q +LR PRV+ + P+ +P + + E + + L Sbjct: 819 LQAITASSANLRHSPRVLVQHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARL 878 Query: 989 D-------DGAAHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHC 1041 + DG M REVWM+VF YLS ++LC CMRVC+TW +WCCDKRLWT+IDL+ C Sbjct: 879 NGRGSWAQDGDESWMQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRC 938 Query: 1042 KSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSS 1101 K+I P LSGII+RQPVSLDLSWTNISKKQL+WL+NRLPGL+DL+L+GCSW AVSAL +S Sbjct: 939 KAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTS 998 Query: 1102 SCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASL 1161 SCPLLRTLD++W G+KD Q+RDLL+PP D +PGQ DNRSKLRN+ + RLAGLDITDA+L Sbjct: 999 SCPLLRTLDLRWAVGIKDPQIRDLLTPPAD-KPGQ-DNRSKLRNMTDFRLAGLDITDATL 1056 Query: 1162 RLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFK 1221 RLIIRHMPLLS+L LS+C+H+TDQS NLLTAVG++TR SLTE+N++ CNK+TDQ L + + Sbjct: 1057 RLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLR 1116 Query: 1222 RCGNICHIDLRYCKQVTKEGCEQFIAEMS 1250 R N+ IDLR CKQ+T++ CE FI+++S Sbjct: 1117 RIANVTLIDLRGCKQITRKACEHFISDLS 1145 >gi|157168349 F-box and leucine-rich repeat protein 19 [Homo sapiens] Length = 694 Score = 594 bits (1531), Expect = e-169 Identities = 318/710 (44%), Positives = 429/710 (60%), Gaps = 59/710 (8%) Query: 555 KGKLGPASAVKLAANRTT----AGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGR 610 KG+ GP++ + + ++ AGARRRRTRCR+C AC+RTECG+CHFC+DMKKFGGPGR Sbjct: 8 KGESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGR 67 Query: 611 MKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLK 670 MKQSC++RQC APVLPHTAVCL+CGEAGKEDTVE EE KF L LMEC+ICNEI+HPGCLK Sbjct: 68 MKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVHPGCLK 127 Query: 671 IKESEGVVNDELPNCWECPKCNHAGKTGKQK-RGPGFKYASNLP--GSLLKEQKMNRD-- 725 + ++EGV+N E+PNCWECP+C G+T K GPG + A N SL K+ + Sbjct: 128 MGKAEGVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPP 187 Query: 726 ------NKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQ 779 ++G PA E P +R + + PP RKK K + + Sbjct: 188 LPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTP-----------RKKVKGGRER 236 Query: 780 ELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESD 839 L K G + L R L P + F P PP+ E Sbjct: 237 HLK-----KVGGDACLLRGSDPGGPGLLPPRVL--NPSQAFSSCH----PGLPPENWEKP 285 Query: 840 HSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANE 899 P AEGP R K E K + ++R ++ ++ Sbjct: 286 K---------PPLASAEGPAVPSPSPQREKL---------ERFKRMCQLLERVPDTSSSS 327 Query: 900 NQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTP--RELRHQLGPSLRSPPRVISRP 957 + S+ PG R ++G +G R R + P P ++S P Sbjct: 328 SDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAVRPGSGGP--LLSWP 385 Query: 958 PPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCM 1017 PP+ Q+ERHV+RPPP SP PD+LPL G+ H + R W+ VF +L ++LC+CM Sbjct: 386 LGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCICM 445 Query: 1018 RVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLIN 1077 RVCRTW+RWC DKRLW R+DL+ KS+TP MLSG++RRQP +LDLSWT +SKKQL WL+N Sbjct: 446 RVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLN 505 Query: 1078 RLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQM 1137 RL GL++LVLSGCSW++VSAL S+ P LR LD++W+E +KD+Q+R+LL PP D +PGQ Sbjct: 506 RLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQT 565 Query: 1138 DNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTT 1197 ++R +L+ + ELRLAGL++TDASLRL++RH P LS L LS+C HV D S++LLTA + Sbjct: 566 ESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPL 625 Query: 1198 RDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIA 1247 R++L +NL+ C+++TD CL F+RC + +DLR C+Q++ E C + A Sbjct: 626 RETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCRQLSPEACARLAA 675 >gi|32698700 PHD finger protein 8 [Homo sapiens] Length = 1024 Score = 291 bits (745), Expect = 3e-78 Identities = 140/296 (47%), Positives = 194/296 (65%), Gaps = 16/296 (5%) Query: 42 KLRSQLYQG--DFVHAMEGKDFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKL 99 +LRS+ + + + G E+++ + VP++ +KDGLG+ +P P FTVRDV+ Sbjct: 90 ELRSRTFDSSDEVILKPTGNQLTVEFLEENSFSVPILVLKKDGLGMTLPSPSFTVRDVEH 149 Query: 100 LVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRP 159 VGS + +DV+DV Q +M + FV+YY + +R+K+ NVISLEFS T+L +LV+ P Sbjct: 150 YVGSDKEIDVIDVTRQADCKMKLGDFVKYYYS--GKREKVLNVISLEFSDTRLSNLVETP 207 Query: 160 TVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSV 219 +V + WV+N+WP+ + P V+KYCLMSV+ +TDFHIDFGGTSV Sbjct: 208 KIVRKLSWVENLWPEE------------CVFERPNVQKYCLMSVRDSYTDFHIDFGGTSV 255 Query: 220 WYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPS 279 WYHV +G KIF+LI PT NL L+E W S Q+++F GD+V++C + +KQG T FIP+ Sbjct: 256 WYHVLKGEKIFYLIRPTNANLTLFECWSSSSNQNEMFFGDQVDKCYKCSVKQGQTLFIPT 315 Query: 280 GWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYV 335 GWIHAV TPVD L FGGN LHS N+ MQL+ YEIE R FR+P + +CWYV Sbjct: 316 GWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFRFPNFETICWYV 371 Score = 31.2 bits (69), Expect = 6.6 Identities = 14/52 (26%), Positives = 25/52 (48%), Gaps = 6/52 (11%) Query: 654 LMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCN--HAGKTGKQKRG 703 ++EC +C + H C+ ++E + D + CP C H K++RG Sbjct: 20 MIECDMCQDWFHGSCVGVEEEKAADID----LYHCPNCEVLHGPSIMKKRRG 67 >gi|90093355 jumonji C domain containing histone demethylase 1 homolog D [Homo sapiens] Length = 941 Score = 274 bits (701), Expect = 3e-73 Identities = 134/320 (41%), Positives = 198/320 (61%), Gaps = 17/320 (5%) Query: 18 RYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQG--DFVHAMEGKDFNYEYVQREALRVPL 75 R+D E + D + V + ++LRS+++ + + M G Y+++ VP+ Sbjct: 102 RHDYTE-IDDGSKPVQAGTRTFIKELRSRVFPSADEIIIKMHGSQLTQRYLEKHGFDVPI 160 Query: 76 IFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQ 135 + + D LG+++P P F+V DV+ VG +++DV+DV Q ++M++ +V+Y+ P Sbjct: 161 MVPKLDDLGLRLPSPTFSVMDVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFMNPN-- 218 Query: 136 RDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKV 195 R K+ NVISLEFS TK+ LV+ P + + WV+N WP + P V Sbjct: 219 RPKVLNVISLEFSDTKMSELVEVPDIAKKLSWVENYWPDD------------SVFPKPFV 266 Query: 196 KKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDI 255 +KYCLM V+ +TDFHIDFGGTSVWYHV G KIF+LI PT NLA YE W S QS++ Sbjct: 267 QKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTDENLARYESWSSSVTQSEV 326 Query: 256 FLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIED 315 F GD+V++C + +KQG+T F+P+GWIHAV T D + FGGN LH+ N+ MQLR YE+E Sbjct: 327 FFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEK 386 Query: 316 RTRVQPKFRYPFYYEMCWYV 335 R + F++PF+ +CW+V Sbjct: 387 RLKTPDLFKFPFFEAICWFV 406 Score = 32.3 bits (72), Expect = 2.9 Identities = 16/54 (29%), Positives = 25/54 (46%), Gaps = 6/54 (11%) Query: 651 NLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCN--HAGKTGKQKR 702 N ++EC IC + H C+ ++E V D + CP C H K++R Sbjct: 49 NRFMIECDICKDWFHGSCVGVEEHHAVDID----LYHCPNCAVLHGSSLMKKRR 98 >gi|117190342 PHD finger protein 2 [Homo sapiens] Length = 1096 Score = 248 bits (632), Expect = 3e-65 Identities = 123/297 (41%), Positives = 175/297 (58%), Gaps = 16/297 (5%) Query: 41 EKLRSQLYQG--DFVHAMEGKDFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVK 98 ++LRS+ + D V + G Y++ P++ +KDGLG+ +P P F V DV+ Sbjct: 91 KELRSRTFPSAEDVVARVPGSQLTLGYMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVE 150 Query: 99 LLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKR 158 VG R VDV DV QK +M + +FV YY + R ++ NV +LEFS T++ V+ Sbjct: 151 NYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYS--TNRKRVLNVTNLEFSDTRMSSFVEP 208 Query: 159 PTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTS 218 P +V + WV+N WP A + PKV KYCL+ VK +TDFHID GG S Sbjct: 209 PDIVKKLSWVENYWPDD------------ALLAKPKVTKYCLICVKDSYTDFHIDSGGAS 256 Query: 219 VWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIP 278 WYHV +G K F+LI P N++LYE W + S++F D+V++C + +KQG T FIP Sbjct: 257 AWYHVLKGEKTFYLIRPASANISLYERWRSASNHSEMFFADQVDKCYKCIVKQGQTLFIP 316 Query: 279 SGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYV 335 SGWI+A TPVD L F G+ LHS +V MQ+R YE+E R ++ ++P + CWY+ Sbjct: 317 SGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYM 373 Score = 33.1 bits (74), Expect = 1.7 Identities = 19/59 (32%), Positives = 27/59 (45%), Gaps = 11/59 (18%) Query: 654 LMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKC--NHAGKTGKQKR-----GPG 705 ++EC C + H C+ ++E E D + CP C H T K+KR GPG Sbjct: 20 MIECDACKDWFHGSCVGVEEEEAPDID----IYHCPNCEKTHGKSTLKKKRTWHKHGPG 74 Score = 33.1 bits (74), Expect = 1.7 Identities = 36/137 (26%), Positives = 55/137 (40%), Gaps = 27/137 (19%) Query: 861 KKKVKMRRKRRLPNKELSRELSKELNHEIQRTEN---SLANENQQPIKSEPESEGE-EPK 916 KK+ + LP +L K+L EI+ +EN ++ E S+ +G+ E + Sbjct: 411 KKQALAEHEDELPEHFKPSQLIKDLAKEIRLSENASKAVRPEVNTVASSDEVCDGDREKE 470 Query: 917 RPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPS--VSPPKCIQMERHVI 974 PP E P+ L ++ S + P+ + P PS PPK Sbjct: 471 EPPSPIEAT---------PPQSLLEKV--SKKKTPKTVKMPKPSKIPKPPK--------- 510 Query: 975 RPPPISPPPDSLPLDDG 991 PP PP +L L DG Sbjct: 511 -PPKPPRPPKTLKLKDG 526 >gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens] Length = 436 Score = 77.8 bits (190), Expect = 6e-14 Identities = 75/269 (27%), Positives = 117/269 (43%), Gaps = 48/269 (17%) Query: 1020 CRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPV--SLDLSWTN-ISKKQLSWLI 1076 C + +++C R +DL C SIT + L + P+ L++SW + ++K + L+ Sbjct: 135 CTSLSKFCSKLR---HLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALV 191 Query: 1077 NRLPGLRDLVLSGCSWIAVSAL--CSSSCPLLRTLDVQWVEGLKDAQMRDLL-------- 1126 GL+ L L GC+ + AL + CP L TL++Q + D + + Sbjct: 192 RGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQS 251 Query: 1127 ------SPPTD---NRPGQMDNRSKL------------------RNIVELRLAGLD---- 1155 S TD N GQ R ++ RN EL L+ Sbjct: 252 LCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQ 311 Query: 1156 ITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQ 1215 ITD++L + H P L L LS+C +TD I L G D L I L +C +TD Sbjct: 312 ITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHL-GNGACAHDQLEVIELDNCPLITDA 370 Query: 1216 CLSFFKRCGNICHIDLRYCKQVTKEGCEQ 1244 L K C ++ I+L C+Q+T+ G ++ Sbjct: 371 SLEHLKSCHSLERIELYDCQQITRAGIKR 399 Score = 65.9 bits (159), Expect = 2e-10 Identities = 68/249 (27%), Positives = 106/249 (42%), Gaps = 45/249 (18%) Query: 998 REVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDL-NHCKSITPLMLSGIIRRQ 1056 +E+ + +FS+L LC C +V R WN D W RIDL + + I ++ Sbjct: 30 KELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVE------ 83 Query: 1057 PVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSAL--CSSSCPLLRTLDVQWV 1114 NISK+ + LR L L GC + +AL + +C + L++ Sbjct: 84 ---------NISKRCGGF-------LRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGC 127 Query: 1115 EGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAG-LDITDASLRLIIRHMPLLSK 1173 DA L SKLR+ L LA IT+ SL+ + PLL + Sbjct: 128 TKTTDATCTSL-----------SKFCSKLRH---LDLASCTSITNMSLKALSEGCPLLEQ 173 Query: 1174 LHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFF-KRCGNICHIDLR 1232 L++S+C+ VT I L L + L C ++ D+ L + C + ++L+ Sbjct: 174 LNISWCDQVTKDGIQAL----VRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQ 229 Query: 1233 YCKQVTKEG 1241 C Q+T EG Sbjct: 230 TCLQITDEG 238 >gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens] Length = 423 Score = 70.9 bits (172), Expect = 7e-12 Identities = 76/290 (26%), Positives = 119/290 (41%), Gaps = 52/290 (17%) Query: 1008 LSHQDLCVCMRV----CRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIR--RQPVSLD 1061 + H +L C ++ C + +R+C + +DL C SIT L GI R L+ Sbjct: 106 IEHLNLNGCTKITDSTCYSLSRFCSKLK---HLDLTSCVSITNSSLKGISEGCRNLEYLN 162 Query: 1062 LSWTN-ISKKQLSWLINRLPGLRDLVLSGCSWIAVSAL-----------------CSS-- 1101 LSW + I+K + L+ GL+ L+L GC+ + AL CS Sbjct: 163 LSWCDQITKDGIEALVRGCRGLKALLLRGCTQLEDEALKHIQNYCHELVSLNLQSCSRIT 222 Query: 1102 ---------SCPLLRTLDVQWVEGLKDAQMRDL---------LSPPTDNRPGQMDNRSKL 1143 C L+ L + L DA + L L + Sbjct: 223 DEGVVQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRLQILEAARCSHLTDAGFTLLA 282 Query: 1144 RNIVELRLAGLD----ITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRD 1199 RN EL L+ ITD++L + H P L L LS+C +TD I L + T + Sbjct: 283 RNCHELEKMDLEECILITDSTLIQLSIHCPKLQALSLSHCELITDDGI-LHLSNSTCGHE 341 Query: 1200 SLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEM 1249 L + L +C +TD L + C + ++L C+QVT+ G ++ A++ Sbjct: 342 RLRVLELDNCLLITDVALEHLENCRGLERLELYDCQQVTRAGIKRMRAQL 391 Score = 54.7 bits (130), Expect = 6e-07 Identities = 56/251 (22%), Positives = 102/251 (40%), Gaps = 29/251 (11%) Query: 998 REVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDL-NHCKSITPLMLSGIIRR- 1055 +E+ + +FS+L LC C ++ + WN D W RIDL N + ++ I +R Sbjct: 17 KELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFNFQIDVEGRVVENISKRC 76 Query: 1056 ----QPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSS--CPLLRTL 1109 + +SL + L + L L+GC+ I S S S C L+ L Sbjct: 77 GGFLRKLSL-RGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHL 135 Query: 1110 DVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLD-ITDASLRLIIRHM 1168 D+ + ++ ++ + RN+ L L+ D IT + ++R Sbjct: 136 DLTSCVSITNSSLKGI--------------SEGCRNLEYLNLSWCDQITKDGIEALVRGC 181 Query: 1169 PLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQ-CLSFFKRCGNIC 1227 L L L C + D+++ + L +NL C+++TD+ + + C + Sbjct: 182 RGLKALLLRGCTQLEDEALKHI----QNYCHELVSLNLQSCSRITDEGVVQICRGCHRLQ 237 Query: 1228 HIDLRYCKQVT 1238 + L C +T Sbjct: 238 ALCLSGCSNLT 248 Score = 31.2 bits (69), Expect = 6.6 Identities = 18/61 (29%), Positives = 31/61 (50%), Gaps = 4/61 (6%) Query: 1201 LTEINLSDCNKVTDQCL-SFFKRCGNICHIDLRYCKQVTKEGC---EQFIAEMSSFQGRS 1256 L +++L C V D L +F + C NI H++L C ++T C +F +++ S Sbjct: 80 LRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHLDLTS 139 Query: 1257 C 1257 C Sbjct: 140 C 140 >gi|156142182 CXXC finger 1 (PHD domain) isoform 1 [Homo sapiens] Length = 660 Score = 67.0 bits (162), Expect = 1e-10 Identities = 27/46 (58%), Positives = 34/46 (73%), Gaps = 1/46 (2%) Query: 576 RRRRTRCRKCEACLRTE-CGECHFCKDMKKFGGPGRMKQSCIMRQC 620 +R C +CEAC RTE CG C FC+DMKKFGGP +++Q C +RQC Sbjct: 163 KRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQC 208 >gi|156142180 CXXC finger 1 (PHD domain) isoform 2 [Homo sapiens] Length = 656 Score = 67.0 bits (162), Expect = 1e-10 Identities = 27/46 (58%), Positives = 34/46 (73%), Gaps = 1/46 (2%) Query: 576 RRRRTRCRKCEACLRTE-CGECHFCKDMKKFGGPGRMKQSCIMRQC 620 +R C +CEAC RTE CG C FC+DMKKFGGP +++Q C +RQC Sbjct: 163 KRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQC 208 >gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens] Length = 491 Score = 66.2 bits (160), Expect = 2e-10 Identities = 85/328 (25%), Positives = 126/328 (38%), Gaps = 52/328 (15%) Query: 953 VISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQD 1012 V S PP ++ P + R RP D LP H M + +FS+L Sbjct: 88 VHSPPPTRLTHP----LIRLASRPQKEQASIDRLP-----DHSM-----VQIFSFLPTNQ 133 Query: 1013 LCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRR-----QPVSLDLSWTNI 1067 LC C RVCR W D RLW I L L + RR V L L + Sbjct: 134 LCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVTV 193 Query: 1068 S------KKQLSWLINRLPGLRDLVLSGCSWIAVSALCS--SSCPLLRTLDVQWVEGLKD 1119 S + L + P LR L +SGC I+ A+ S CP L LDV + Sbjct: 194 SGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTC 253 Query: 1120 AQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDA------SLRLIIRHMPLLSK 1173 + S G+ ++ + LD+TD L I H L+ Sbjct: 254 ISLTREASIKLSPLHGK-----------QISIRYLDMTDCFVLEDEGLHTIAAHCTQLTH 302 Query: 1174 LHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCL-SFFKRCGNICHIDLR 1232 L+L C +TD+ + L S+ E+++SDC V+D L K + ++ + Sbjct: 303 LYLRRCVRLTDEGLRYLVIYCA----SIKELSVSDCRFVSDFGLREIAKLESRLRYLSIA 358 Query: 1233 YCKQVTKEGCE---QFIAEMSSFQGRSC 1257 +C +VT G ++ +++ R C Sbjct: 359 HCGRVTDVGIRYVAKYCSKLRYLNARGC 386 >gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens] Length = 418 Score = 63.5 bits (153), Expect = 1e-09 Identities = 68/272 (25%), Positives = 114/272 (41%), Gaps = 32/272 (11%) Query: 999 EVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLN-HCKSITP-----LMLSGI 1052 E+ +F YL +D +VC W K +W ++ H + P L GI Sbjct: 11 ELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGI 70 Query: 1053 IRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQ 1112 R Q +SL ++ LS++I + + L LSGC + + L + VQ Sbjct: 71 RRVQILSL--------RRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAF--------VQ 114 Query: 1113 WVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGL-DITDASLRLIIRHMPLL 1171 + L+ + L TD+ G++ L+ + L L G +IT+ L LI + L Sbjct: 115 EIGSLRALNL-SLCKQITDSSLGRI--AQYLKGLEVLELGGCSNITNTGLLLIAWGLQRL 171 Query: 1172 SKLHLSYCNHVTDQSINLLTAVGTTTRD---SLTEINLSDCNKVTDQCLSFFKR-CGNIC 1227 L+L C H++D I L + + + L ++ L DC K+TD L R + Sbjct: 172 KSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLR 231 Query: 1228 HIDLRYCKQVTKEGCEQF--IAEMSSFQGRSC 1257 ++L +C ++ G + + S RSC Sbjct: 232 LLNLSFCGGISDAGLLHLSHMGSLRSLNLRSC 263 Score = 52.0 bits (123), Expect = 4e-06 Identities = 56/219 (25%), Positives = 94/219 (42%), Gaps = 37/219 (16%) Query: 1036 IDLNHCKSITPLMLSGIIRRQPVSLD--LSWTNISKKQLSWLINRLPGLRDLVLSGCSWI 1093 + + H +T G + + ++L T++S K +S L GLR L LS C I Sbjct: 185 VGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHIS---RGLTGLRLLNLSFCGGI 241 Query: 1094 AVSALCS-SSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLA 1152 + + L S LR+L+++ + + D + L + LRL+ Sbjct: 242 SDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLA-------------------MGSLRLS 282 Query: 1153 GLDIT------DASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINL 1206 GLD++ D SL I + + L L L C H++D IN + L +N+ Sbjct: 283 GLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSC-HISDDGINRMVR----QMHGLRTLNI 337 Query: 1207 SDCNKVTDQCLSFF-KRCGNICHIDLRYCKQVTKEGCEQ 1244 C ++TD+ L + + IDL C ++TK G E+ Sbjct: 338 GQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLER 376 >gi|195927037 DNA (cytosine-5-)-methyltransferase 1 isoform a [Homo sapiens] Length = 1632 Score = 62.0 bits (149), Expect = 3e-09 Identities = 25/43 (58%), Positives = 30/43 (69%) Query: 578 RRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQC 620 +R RC CE C + ECG+C CKDM KFGG GR KQ+C R+C Sbjct: 665 KRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQACQERRC 707 Score = 36.6 bits (83), Expect = 0.16 Identities = 58/248 (23%), Positives = 94/248 (37%), Gaps = 62/248 (25%) Query: 732 PAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRLK--- 788 PAKR+ + EE+ R +SDE K+ K + EK + ++ R+R+ Sbjct: 191 PAKRKPQ-EESERAKSDESIKE----------------EDKDQDEKRRRVTSRERVARPL 233 Query: 789 PGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTA 848 P +E + + R+ K E+R K LR +EP PK + + + Sbjct: 234 PAEEPERAKSGTRTEKE-EERDEKEEKRLRSQTKEP-------TPKQKLKEEPDREARAG 285 Query: 849 GPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEP 908 + E +G E+ +K K R K+L+ + E E N Q + Sbjct: 286 VQADEDEDGDEKDEK-----KHRSQPKDLAAKRRPE--------EKEPEKVNPQISDEKD 332 Query: 909 ESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQ 968 E E EE +R TP+E P+ + R + PPKCIQ Sbjct: 333 EDEKEEKRR---------------KTTPKE------PTEKKMARAKTVMNSKTHPPKCIQ 371 Query: 969 MERHVIRP 976 +++ P Sbjct: 372 CGQYLDDP 379 >gi|4503351 DNA (cytosine-5-)-methyltransferase 1 isoform b [Homo sapiens] Length = 1616 Score = 62.0 bits (149), Expect = 3e-09 Identities = 25/43 (58%), Positives = 30/43 (69%) Query: 578 RRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQC 620 +R RC CE C + ECG+C CKDM KFGG GR KQ+C R+C Sbjct: 649 KRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQACQERRC 691 Score = 36.6 bits (83), Expect = 0.16 Identities = 58/248 (23%), Positives = 94/248 (37%), Gaps = 62/248 (25%) Query: 732 PAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRLK--- 788 PAKR+ + EE+ R +SDE K+ K + EK + ++ R+R+ Sbjct: 175 PAKRKPQ-EESERAKSDESIKE----------------EDKDQDEKRRRVTSRERVARPL 217 Query: 789 PGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTA 848 P +E + + R+ K E+R K LR +EP PK + + + Sbjct: 218 PAEEPERAKSGTRTEKE-EERDEKEEKRLRSQTKEP-------TPKQKLKEEPDREARAG 269 Query: 849 GPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEP 908 + E +G E+ +K K R K+L+ + E E N Q + Sbjct: 270 VQADEDEDGDEKDEK-----KHRSQPKDLAAKRRPE--------EKEPEKVNPQISDEKD 316 Query: 909 ESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQ 968 E E EE +R TP+E P+ + R + PPKCIQ Sbjct: 317 EDEKEEKRR---------------KTTPKE------PTEKKMARAKTVMNSKTHPPKCIQ 355 Query: 969 MERHVIRP 976 +++ P Sbjct: 356 CGQYLDDP 363 >gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens] Length = 479 Score = 59.7 bits (143), Expect = 2e-08 Identities = 84/384 (21%), Positives = 142/384 (36%), Gaps = 98/384 (25%) Query: 950 PPRVISRPPPSVSPPKCIQMERHVIRPPPISP---PPDSLPLDDGAAH---VMHREVWMA 1003 PP + PPPS++ P + R + P +P P +L A ++ Sbjct: 49 PPPPPTLPPPSLAAP----LSRAALAGGPCTPAGGPASALAPGHPAERPPLATDEKILNG 104 Query: 1004 VFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRI--------------------------- 1036 +F Y S + CV +VC+ W R + W + Sbjct: 105 LFWYFSACEKCVLAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNLQGFA 164 Query: 1037 -------------DLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLR 1083 DL+ C+ I LS ++ ++ L + I+ L ++ ++ G+ Sbjct: 165 ARGFEGFCLVGVSDLDICEFIDNYALS---KKGVKAMSLKRSTITDAGLEVMLEQMQGVV 221 Query: 1084 DLVLSGCS-------WIAVSA----LCSSSC---------------PLLRTLDVQWV--- 1114 L LSGC+ W ++SA L S C P L L +Q Sbjct: 222 RLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVT 281 Query: 1115 ----------EGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLD-ITDASLRL 1163 +G +R LLS G ++ L N+ L L+G +TD + L Sbjct: 282 DTALAYFTARQGHSTHTLR-LLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVEL 340 Query: 1164 IIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRC 1223 + ++ L L LS+C +TD ++ + L E+ L C ++TD LS+ Sbjct: 341 VAENLRKLRSLDLSWCPRITDMALEYVAC----DLHRLEELVLDRCVRITDTGLSYLSTM 396 Query: 1224 GNICHIDLRYCKQVTKEGCEQFIA 1247 ++ + LR+C QV G + +A Sbjct: 397 SSLRSLYLRWCCQVQDFGLKHLLA 420 >gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] Length = 904 Score = 58.9 bits (141), Expect = 3e-08 Identities = 80/306 (26%), Positives = 114/306 (37%), Gaps = 79/306 (25%) Query: 717 LKEQKMNRD--NKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRK 774 +K+Q ++D +KE +E ++ + E +PRRR S+ P RR+S V +KR Sbjct: 144 MKKQDEDKDKRDKEEKESSREKRERSRSPRRRK---SRSPSP----RRRSSPVRRERKRS 196 Query: 775 YEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPK 834 + + R K RS A + K+E ELPE K Sbjct: 197 HSRSPR---------------HRTKSRSPSPAPE------------KKEKTPELPEPSVK 229 Query: 835 TRESDHSRSSS-------PTAGPSTEGAE-GPE-----EKKKVKMRRKRRLPNKELSREL 881 +E ++S P P E E PE EK+K K R + R +K SR Sbjct: 230 VKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTR 289 Query: 882 SKELNHEIQRTENSLANENQQPIKSEPESEGEEPKR--PPGICERPHRFSKGLNGTPREL 939 S+ +H R + + + P + P+R PP P R + + R Sbjct: 290 SRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRR 349 Query: 940 RHQLGPS---------------------LRSPPRVISRPPPSVSPPKCIQMERHVIRP-P 977 R S SPPR R PS SPP+ RH RP P Sbjct: 350 RSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPR----RRH--RPSP 403 Query: 978 PISPPP 983 P +PPP Sbjct: 404 PATPPP 409 Score = 55.8 bits (133), Expect = 2e-07 Identities = 57/271 (21%), Positives = 98/271 (36%), Gaps = 33/271 (12%) Query: 718 KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEK 777 +E++ +R+ +E +RR +PRRRS ++ R++S R + K Sbjct: 157 EEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRE-------RKRSHSRSPRHRTKSRS 209 Query: 778 PQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPE------- 830 P +K P + + K S + A + P EP++ PE Sbjct: 210 PSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEK 269 Query: 831 ----APPKTRESDHSRSSSPTAGPS----------TEGAEGPEEKKKVKMR---RKRRLP 873 P++R SRS + + PS + P + + R R+R P Sbjct: 270 EKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPP 329 Query: 874 NKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGL- 932 + + ++R S A+ + S PK+PP P R ++ L Sbjct: 330 RRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLS 389 Query: 933 -NGTPRELRHQLGPSLRSPPRVISRPPPSVS 962 + +P RH+ P PP+ P P S Sbjct: 390 PSASPPRRRHRPSPPATPPPKTRHSPTPQQS 420 Score = 45.4 bits (106), Expect = 3e-04 Identities = 65/291 (22%), Positives = 100/291 (34%), Gaps = 54/291 (18%) Query: 726 NKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRK 785 + E + P + + E RRR S+ P R+K R++R P R+ Sbjct: 501 SSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPT---RR 557 Query: 786 RLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPE-------APPKTRES 838 R P +RR R + P RR P P +PP R Sbjct: 558 RRSPSPAPP---PRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKR-- 612 Query: 839 DHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLAN 898 R++SP P + P K++V P K+ S ++K + + +S Sbjct: 613 ---RTASPPPPPKRRASPSPPPKRRVS----HSPPPKQRSSPVTKRRSPSL----SSKHR 661 Query: 899 ENQQPIKSEPESEGEEPK---------RPPGICERPHRFSKGLNGTPRELRHQLGPSLRS 949 + P +S E+ +P R P P +G + +P+ R PS R Sbjct: 662 KGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQR-RQSPSPSTR- 719 Query: 950 PPRVISRPP----------PSVSPPKCIQMERHV-------IRPPPISPPP 983 P R +SR P PS + + R V + PP P P Sbjct: 720 PIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSP 770 Score = 37.4 bits (85), Expect = 0.092 Identities = 57/249 (22%), Positives = 92/249 (36%), Gaps = 45/249 (18%) Query: 699 KQKRGPGFKYAS-NLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPD 757 KQ+ P K S +L K +R +E + P + +PR R+ + S PP Sbjct: 642 KQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRH-SPSPRPRAPQTSSSPPP- 699 Query: 758 GLLRRKSDDVHLRKKRKYEKPQELSGRKRL-KPGKEDKLFRKKRRSWKNAEDRMALANKP 816 +RR + R++ + + R +P K K +S + +++ P Sbjct: 700 --VRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSP 757 Query: 817 LRRFKQEPEDELPEAPPKTRESDH-----------SRSSSPTAGPST------EGAEGPE 859 EP + P APP +S ++ SPT PS EG + Sbjct: 758 ------EPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKK 811 Query: 860 EKKKVKMRRKRRLPNKELSRELSKEL---------NHEIQRTENSLANENQQPI-----K 905 +KKK K +K + K + K + I +LA E +P+ K Sbjct: 812 KKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQE--EPVAAPEPK 869 Query: 906 SEPESEGEE 914 E ESE E+ Sbjct: 870 KETESEAED 878 Score = 34.7 bits (78), Expect = 0.59 Identities = 35/136 (25%), Positives = 58/136 (42%), Gaps = 23/136 (16%) Query: 377 LEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPALR 436 ++ ++E D++ +EE+E E R R+P+ S SP ++ +P R Sbjct: 144 MKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSP------------RRRSSPVRR 191 Query: 437 FLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESL 496 KR+ S KS ++P SPA E K L E +K + V++ S Sbjct: 192 ERKRSHSRSPRHRTKS--------RSP--SPAPEKKEKTPELPEPSVKVKEPSVQEATST 241 Query: 497 PENKKC-VPEGIEDPQ 511 + K PE I +P+ Sbjct: 242 SDILKVPKPEPIPEPK 257 >gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2 [Homo sapiens] Length = 690 Score = 58.5 bits (140), Expect = 4e-08 Identities = 63/251 (25%), Positives = 102/251 (40%), Gaps = 39/251 (15%) Query: 1002 MAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLD 1061 + +F YLS +D+ +C +V W LW ID + K++ P + VS Sbjct: 164 LQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIP-------DKYIVSTL 216 Query: 1062 LSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQ 1121 W RL LR L GC + S C L+ L+V D Sbjct: 217 QRW-------------RLNVLR-LNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDES 262 Query: 1122 MRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNH 1181 MR + ++ PG ++ L L+ IT+ ++RL+ RH L L L+YC Sbjct: 263 MRHI----SEGCPG----------VLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRR 308 Query: 1182 VTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFF-KRCGNICHIDLRYCKQVTKE 1240 TD+ + L +G L ++LS C +++ Q + C I H+ + +T + Sbjct: 309 FTDKGLQYLN-LGNGCH-KLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLT-D 365 Query: 1241 GCEQFIAEMSS 1251 C + + E S Sbjct: 366 NCVKALVEKCS 376 Score = 51.2 bits (121), Expect = 6e-06 Identities = 51/218 (23%), Positives = 96/218 (44%), Gaps = 38/218 (17%) Query: 1085 LVLSGCSWIAVSAL--CSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPT-------DNRPG 1135 L LSGC+ I+V ++SC + L + + L D ++ L+ + P Sbjct: 329 LDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPH 388 Query: 1136 QMDNRSKLRNIVELRLAGLD----ITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLT 1191 D + + +LR + +TDAS + I ++ P LS ++++ C +TD S+ L+ Sbjct: 389 ISDCTFRALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS 448 Query: 1192 AVGTTTRDSLT-----------------------EINLSDCNKVTD-QCLSFFKRCGNIC 1227 + T +L E+NLS+C +++D + +RC N+ Sbjct: 449 PLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLN 508 Query: 1228 HIDLRYCKQVTKEGCEQFIAEMSSFQGRSCSTTRLGDE 1265 ++ LR C+ +T +G +I + S S T + +E Sbjct: 509 YLSLRNCEHLTAQGI-GYIVNIFSLVSIDLSGTDISNE 545 Score = 44.3 bits (103), Expect = 7e-04 Identities = 41/174 (23%), Positives = 84/174 (48%), Gaps = 22/174 (12%) Query: 1082 LRDLVLSGCSWIAVSALC--SSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDN 1139 +R+L LS C ++ +++ S CP L L ++ E L T G + N Sbjct: 481 IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHL------------TAQGIGYIVN 528 Query: 1140 RSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTA---VGTT 1196 + ++V + L+G DI++ L ++ RH L +L +S C +TD I + + + + Sbjct: 529 ---IFSLVSIDLSGTDISNEGLNVLSRHKK-LKELSVSECYRITDDGIQITDSAMEMLSA 584 Query: 1197 TRDSLTEINLSDCNKVTDQCLSFFK-RCGNICHIDLRYCKQVTKEGCEQFIAEM 1249 L +++S C +TDQ L + C + + ++YC ++K+ ++ +++ Sbjct: 585 KCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSSKV 638 >gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1 [Homo sapiens] Length = 735 Score = 58.5 bits (140), Expect = 4e-08 Identities = 63/251 (25%), Positives = 102/251 (40%), Gaps = 39/251 (15%) Query: 1002 MAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLD 1061 + +F YLS +D+ +C +V W LW ID + K++ P + VS Sbjct: 164 LQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIP-------DKYIVSTL 216 Query: 1062 LSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQ 1121 W RL LR L GC + S C L+ L+V D Sbjct: 217 QRW-------------RLNVLR-LNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDES 262 Query: 1122 MRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNH 1181 MR + ++ PG ++ L L+ IT+ ++RL+ RH L L L+YC Sbjct: 263 MRHI----SEGCPG----------VLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRR 308 Query: 1182 VTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFF-KRCGNICHIDLRYCKQVTKE 1240 TD+ + L +G L ++LS C +++ Q + C I H+ + +T + Sbjct: 309 FTDKGLQYLN-LGNGCH-KLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLT-D 365 Query: 1241 GCEQFIAEMSS 1251 C + + E S Sbjct: 366 NCVKALVEKCS 376 Score = 51.2 bits (121), Expect = 6e-06 Identities = 51/218 (23%), Positives = 96/218 (44%), Gaps = 38/218 (17%) Query: 1085 LVLSGCSWIAVSAL--CSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPT-------DNRPG 1135 L LSGC+ I+V ++SC + L + + L D ++ L+ + P Sbjct: 329 LDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPH 388 Query: 1136 QMDNRSKLRNIVELRLAGLD----ITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLT 1191 D + + +LR + +TDAS + I ++ P LS ++++ C +TD S+ L+ Sbjct: 389 ISDCTFRALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS 448 Query: 1192 AVGTTTRDSLT-----------------------EINLSDCNKVTD-QCLSFFKRCGNIC 1227 + T +L E+NLS+C +++D + +RC N+ Sbjct: 449 PLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLN 508 Query: 1228 HIDLRYCKQVTKEGCEQFIAEMSSFQGRSCSTTRLGDE 1265 ++ LR C+ +T +G +I + S S T + +E Sbjct: 509 YLSLRNCEHLTAQGI-GYIVNIFSLVSIDLSGTDISNE 545 Score = 40.4 bits (93), Expect = 0.011 Identities = 41/183 (22%), Positives = 83/183 (45%), Gaps = 24/183 (13%) Query: 1082 LRDLVLSGCSWIAVSALC--SSSCPLLRTLDVQWVEGLKDAQMRDLLS---------PPT 1130 +R+L LS C ++ +++ S CP L L ++ E L + +++ T Sbjct: 481 IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGT 540 Query: 1131 DNRPGQMDNRSKLRNIVELRLAGL-DITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINL 1189 D ++ S+ + + EL ++ ITD ++ + +L L +SYC+ ++D I Sbjct: 541 DISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKA 600 Query: 1190 LTAVGTTTRDSLTEINLSDCNKVTDQCLSFFK-RCGNICHIDLRYCKQVTKE-------G 1241 L +LT ++++ C K+TD + +C + +D+ C +T + G Sbjct: 601 LAIYCI----NLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIG 656 Query: 1242 CEQ 1244 C+Q Sbjct: 657 CKQ 659 >gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo sapiens] Length = 424 Score = 57.4 bits (137), Expect = 9e-08 Identities = 67/276 (24%), Positives = 117/276 (42%), Gaps = 51/276 (18%) Query: 999 EVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITP-----LMLSGII 1053 E+ + +FS L +L VC+ W R D+ LW +DL K++ P L+ G+I Sbjct: 103 ELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTG-KNLHPDVTGRLLSQGVI 161 Query: 1054 --------RRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPL 1105 QP++ S + LS + + L ++ S C Sbjct: 162 AFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLHGIL--------------SQCSK 207 Query: 1106 LRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLD-ITDASLRLI 1164 L+ L +EGL+ LS P N +K N+V L L+G ++ +L+ + Sbjct: 208 LQNLS---LEGLR-------LSDPIVN------TLAKNSNLVRLNLSGCSGFSEFALQTL 251 Query: 1165 IRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNK--VTDQCLSFFKR 1222 + L +L+LS+C T++ + + A +++T++NLS K + +R Sbjct: 252 LSSCSRLDELNLSWCFDFTEKHVQVAVA---HVSETITQLNLSGYRKNLQKSDLSTLVRR 308 Query: 1223 CGNICHIDLRYCKQVTKEGCEQFIAEMSSFQGRSCS 1258 C N+ H+DL + K C Q +++ Q S S Sbjct: 309 CPNLVHLDLS-DSVMLKNDCFQEFFQLNYLQHLSLS 343 >gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo sapiens] Length = 410 Score = 57.4 bits (137), Expect = 9e-08 Identities = 67/276 (24%), Positives = 117/276 (42%), Gaps = 51/276 (18%) Query: 999 EVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITP-----LMLSGII 1053 E+ + +FS L +L VC+ W R D+ LW +DL K++ P L+ G+I Sbjct: 103 ELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTG-KNLHPDVTGRLLSQGVI 161 Query: 1054 --------RRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPL 1105 QP++ S + LS + + L ++ S C Sbjct: 162 AFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLHGIL--------------SQCSK 207 Query: 1106 LRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLD-ITDASLRLI 1164 L+ L +EGL+ LS P N +K N+V L L+G ++ +L+ + Sbjct: 208 LQNLS---LEGLR-------LSDPIVN------TLAKNSNLVRLNLSGCSGFSEFALQTL 251 Query: 1165 IRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNK--VTDQCLSFFKR 1222 + L +L+LS+C T++ + + A +++T++NLS K + +R Sbjct: 252 LSSCSRLDELNLSWCFDFTEKHVQVAVA---HVSETITQLNLSGYRKNLQKSDLSTLVRR 308 Query: 1223 CGNICHIDLRYCKQVTKEGCEQFIAEMSSFQGRSCS 1258 C N+ H+DL + K C Q +++ Q S S Sbjct: 309 CPNLVHLDLS-DSVMLKNDCFQEFFQLNYLQHLSLS 343 >gi|21464115 methyl-CpG binding domain protein 1 isoform 2 [Homo sapiens] Length = 586 Score = 55.1 bits (131), Expect = 4e-07 Identities = 23/47 (48%), Positives = 29/47 (61%), Gaps = 1/47 (2%) Query: 576 RRRRTRCRKCEACLRT-ECGECHFCKDMKKFGGPGRMKQSCIMRQCI 621 RR+ +C C ACLR +CG C FC D KFGG + +Q C RQC+ Sbjct: 309 RRQNRKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCL 355 >gi|21464119 methyl-CpG binding domain protein 1 isoform PCM1 [Homo sapiens] Length = 556 Score = 55.1 bits (131), Expect = 4e-07 Identities = 23/47 (48%), Positives = 29/47 (61%), Gaps = 1/47 (2%) Query: 576 RRRRTRCRKCEACLRT-ECGECHFCKDMKKFGGPGRMKQSCIMRQCI 621 RR+ +C C ACLR +CG C FC D KFGG + +Q C RQC+ Sbjct: 283 RRQNRKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCL 329 >gi|21464117 methyl-CpG binding domain protein 1 isoform 1 [Homo sapiens] Length = 605 Score = 55.1 bits (131), Expect = 4e-07 Identities = 23/47 (48%), Positives = 29/47 (61%), Gaps = 1/47 (2%) Query: 576 RRRRTRCRKCEACLRT-ECGECHFCKDMKKFGGPGRMKQSCIMRQCI 621 RR+ +C C ACLR +CG C FC D KFGG + +Q C RQC+ Sbjct: 332 RRQNRKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCL 378 >gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sapiens] Length = 2715 Score = 54.7 bits (130), Expect = 6e-07 Identities = 23/48 (47%), Positives = 27/48 (56%), Gaps = 1/48 (2%) Query: 574 GARRRRTRCRKCEACLRTE-CGECHFCKDMKKFGGPGRMKQSCIMRQC 620 G + R RC C CLR + CG C C D KFGGP KQ C+ R+C Sbjct: 958 GKKMRMARCGHCRGCLRVQDCGSCVNCLDKPKFGGPNTKKQCCVYRKC 1005 Score = 36.6 bits (83), Expect = 0.16 Identities = 27/115 (23%), Positives = 43/115 (37%), Gaps = 8/115 (6%) Query: 867 RRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPH 926 +++++L ++E ++ +E + E + E E P + E++ P P P Sbjct: 356 KQEQKLDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPPLTPPAPSPPP 415 Query: 927 RFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISP 981 P P L PP PPP SPP E PPP+ P Sbjct: 416 PLPPPSTSPP--------PPLCPPPPPPVSPPPLPSPPPPPAQEEQEESPPPVVP 462 Score = 34.3 bits (77), Expect = 0.77 Identities = 76/362 (20%), Positives = 115/362 (31%), Gaps = 82/362 (22%) Query: 692 NHAGKTGKQK-RGPGFKYASNLPGSLLKEQKMNRDN---KEGQEPAKRRSECEEAPRRRS 747 + G+ G+ + RG G + S K+ KM + + + GQ + ++ P+RR Sbjct: 286 SRGGRGGRGRGRGGGLPFVIKFV-SRAKKVKMGQLSLGLESGQGQGQHEESWQDVPQRRV 344 Query: 748 DEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAE 807 P +K DD KK + EK +E G + KE++ ++ E Sbjct: 345 GSGQGGSPCWKKQEQKLDDEEEEKKEEEEKDKE--GEE-----KEERAVAEEMMPAAEKE 397 Query: 808 DRMALANKPLRRFKQEPEDELPEA----------PPKTRESDHSRSSSPTAGPSTEGAEG 857 + L PL P LP PP S S P E E Sbjct: 398 EAK-LPPPPLTPPAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQEEQEES 456 Query: 858 PEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKR 917 P RKR P S+ +E + P + + G P+ Sbjct: 457 PPPVVPATCSRKRGRPPLTPSQRAERE-------AARAGPEGTSPPTPTPSTATGGPPED 509 Query: 918 PPGICERPHRFSKGLNG---------------TPREL---------RHQLGPSLRSP--- 950 P + + F K + TPR + ++ P LR P Sbjct: 510 SPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEVSPVLRPPITT 569 Query: 951 -PRVISRPPPSVSPPKC----------IQMERHVIR--------------PPPISPPPDS 985 P V P P SPP+ + R ++R PPP +PPP Sbjct: 570 SPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPP 629 Query: 986 LP 987 P Sbjct: 630 AP 631 Score = 32.3 bits (72), Expect = 2.9 Identities = 18/70 (25%), Positives = 29/70 (41%), Gaps = 12/70 (17%) Query: 630 VCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECP 689 VCL+C G + L+ C +C + HP CL+ E + + C C Sbjct: 1203 VCLLCASKGLHE------------LVFCQVCCDPFHPFCLEEAERPLPQHHDTWCCRRCK 1250 Query: 690 KCNHAGKTGK 699 C+ G+ G+ Sbjct: 1251 FCHVCGRKGR 1260 Score = 32.0 bits (71), Expect = 3.8 Identities = 35/150 (23%), Positives = 49/150 (32%), Gaps = 8/150 (5%) Query: 815 KPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPN 874 K RRF DE P PPK S R T+ P + + +P Sbjct: 541 KTPRRFM----DEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPL 596 Query: 875 KELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNG 934 E R + +E SL E P + P P P R + Sbjct: 597 PEKRRSILREPTFRW----TSLTRELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQF 652 Query: 935 TPRELRHQLGPSLRSPPRVISRPPPSVSPP 964 TP E ++ S+ +PP + + P PP Sbjct: 653 TPSEAHLKIYESVLTPPPLGAPEAPEPEPP 682 >gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] Length = 275 Score = 54.3 bits (129), Expect = 7e-07 Identities = 39/177 (22%), Positives = 77/177 (43%), Gaps = 18/177 (10%) Query: 718 KEQKMNRDNKE---------GQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVH 768 KE+K R KE G+E ++R E E+ + R ++ +K + R + Sbjct: 52 KERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGR 111 Query: 769 LRKKRKYEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDEL 828 +K+K E+ + K+ + K K +KKRR + E + ++ K+E ++ Sbjct: 112 RERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKK 171 Query: 829 PEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKEL 885 E K R+ + R E E +E+KK + ++K R +++ R+ ++ Sbjct: 172 RERNRKERKKERERK---------ERRERKKERKKERRKKKERKKDRKTDRQTDSQV 219 Score = 49.7 bits (117), Expect = 2e-05 Identities = 51/199 (25%), Positives = 81/199 (40%), Gaps = 24/199 (12%) Query: 720 QKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQ 779 Q+ + KE +E KR+ E E+ +R + KK RKKR+ K + Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKK---------------RKKRERGKER 75 Query: 780 ELSGRKRLKPGKEDK-LFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRES 838 E ++R K KE + R+KR+ K +R + ++ K+ E E + R+ Sbjct: 76 ERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKR 135 Query: 839 DHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELS-KELNHEIQRTENSLA 897 R E G E+K R+KR+ +E RE + KE E +R E Sbjct: 136 KKRRKKKRRKERKREKERGKRERK----RKKRKKEEREKKRERNRKERKKERERKER--- 188 Query: 898 NENQQPIKSEPESEGEEPK 916 E ++ K E + E K Sbjct: 189 RERKKERKKERRKKKERKK 207 Score = 47.8 bits (112), Expect = 7e-05 Identities = 48/212 (22%), Positives = 88/212 (41%), Gaps = 17/212 (8%) Query: 718 KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEK 777 +E + ++ +E +E KR E E R E K+ + R+ K+RK + Sbjct: 32 RESERKKERRE-REKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERR 90 Query: 778 PQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRE 837 +E RK+ K +E K ++ RR K ++R + R KQ E + + K R Sbjct: 91 EKERRKRKKEKKKRERK--QRGRRERKKKKER----KERERENKQRRERKRKKRRKKKRR 144 Query: 838 SDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLA 897 + R E G E+K+ K +++ R +E +R+ K+ +R E Sbjct: 145 KERKR----------EKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKE 194 Query: 898 NENQQPIKSEPESEGEEPKRPPGICERPHRFS 929 + ++ K E + + + ++ RP R S Sbjct: 195 RKKERRKKKERKKDRKTDRQTDSQVFRPLRES 226 Score = 32.7 bits (73), Expect = 2.3 Identities = 31/117 (26%), Positives = 55/117 (47%), Gaps = 6/117 (5%) Query: 696 KTGKQKRGPGFKYASNLPGSLLKEQK-MNRDNKEGQEPA--KRRSECEEAPRRRSDEHSK 752 K K+K+ K KE+K R+NK+ +E KRR + R+R E K Sbjct: 96 KRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGK 155 Query: 753 KVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDR 809 + R+K + R++ + E+ +E ++R + KE K R+K++ + +DR Sbjct: 156 R-ERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKK--ERKKDR 209 >gi|55741709 RNA binding motif protein 25 [Homo sapiens] Length = 843 Score = 53.5 bits (127), Expect = 1e-06 Identities = 59/249 (23%), Positives = 103/249 (41%), Gaps = 21/249 (8%) Query: 718 KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEK 777 ++++ R+ + +E + R E R R E ++ D R+ D+ ++RK E+ Sbjct: 389 RDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLER 448 Query: 778 P---QELSGRKRLKPG--KEDKLFRKKRRSWKNAEDR---MALANKPLRRFKQEPEDELP 829 +E + ++RLK +E K R+ + + E+R MA K L+ F ++ +D+ Sbjct: 449 KLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRD 508 Query: 830 EAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEI 889 + PK + E E +++K ++ R+ L E + + E+ Sbjct: 509 D--PKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQ----RLLAEGHPDPDAEL 562 Query: 890 QRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRS 949 QR E Q IK EPESE EE E+ + K E + P L+ Sbjct: 563 QRMEQEAERRRQPQIKQEPESEEEEE-------EKQEKEEKREEPMEEEEEPEQKPCLKP 615 Query: 950 PPRVISRPP 958 R IS P Sbjct: 616 TLRPISSAP 624 Score = 38.1 bits (87), Expect = 0.054 Identities = 52/227 (22%), Positives = 95/227 (41%), Gaps = 23/227 (10%) Query: 707 KYASNLPGSLLKEQKMNRDNKEGQEPAKRRSEC-EEAPRRRSDEHSKKVPPDGLLRRKSD 765 K ASN G+ E N D + E KRR + + A E+S ++ + Sbjct: 176 KKASN--GNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPS----QES 229 Query: 766 DVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRKKR-RSWKNAEDRMALANKPLRRF---- 820 D H RKK+K EK +++ R + P L K+ + + ED+ L ++ + +F Sbjct: 230 DSHPRKKKK-EKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTH 288 Query: 821 --------KQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRL 872 K+E E + E + RE + R E EK+K + R + R Sbjct: 289 KKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERD 348 Query: 873 PNKELSRELSKELNHEIQRTEN--SLANENQQPIKSEPESEGEEPKR 917 +++ ++E ++ + E R + ++ N+ +S +S E +R Sbjct: 349 RDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERER 395 >gi|148746195 trichohyalin [Homo sapiens] Length = 1943 Score = 53.5 bits (127), Expect = 1e-06 Identities = 49/208 (23%), Positives = 97/208 (46%), Gaps = 13/208 (6%) Query: 718 KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEK 777 +++++ R +E QE +RR+E E+ + E +++ P + LRR+ + + LR+K + EK Sbjct: 169 RDEELWRQRQEWQEREERRAEEEQLQSCKGHE-TEEFPDEEQLRRR-ELLELRRKGREEK 226 Query: 778 PQELSGRK-RLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDEL-----PEA 831 Q+ R+ R+ +E+K +RK+ + E+++ +R QE E++L E Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286 Query: 832 PPKTRESDHS-----RSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELN 886 + +E + R E E EE+++ + RR+++ +E +E Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEER 346 Query: 887 HEIQRTENSLANENQQPIKSEPESEGEE 914 E Q +Q ++ E E E E Sbjct: 347 REQQLRREQEEERREQQLRREQEEERRE 374 Score = 50.1 bits (118), Expect = 1e-05 Identities = 52/246 (21%), Positives = 101/246 (41%), Gaps = 38/246 (15%) Query: 718 KEQKMNRDNKE--GQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKY 775 +E+++ ++ ++ +EP KRR + E R+ +E + + LLR + + ++R+Y Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQ--ELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199 Query: 776 EKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPL------------------ 817 + +EL +KR + +++ + W+ ++ NK Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLR 1259 Query: 818 -RRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKE 876 R+ +Q+ + L E + RE + R E EE+K+ K R ++ K+ Sbjct: 1260 DRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQ 1319 Query: 877 LSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTP 936 L RE +R E E + + E + E ++P ER +F + Sbjct: 1320 LLRE---------EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFRE------ 1364 Query: 937 RELRHQ 942 ELRHQ Sbjct: 1365 EELRHQ 1370 Score = 49.3 bits (116), Expect = 2e-05 Identities = 41/203 (20%), Positives = 91/203 (44%), Gaps = 15/203 (7%) Query: 718 KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEK 777 +++K + ++ + + R +E + R E +K + LR++++ LR++ +Y K Sbjct: 1689 RDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRK 1748 Query: 778 PQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRE 837 E ++L+P +E++ R++ R DR + LR+ ++E + E+ K RE Sbjct: 1749 ILE---EEQLRPEREEQQLRRQER------DRKFREEEQLRQEREEQQLRSQESDRKFRE 1799 Query: 838 SDHSRS--SSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKE----LNHEIQR 891 + R P + E++++++ + + +E R+ E + +R Sbjct: 1800 EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859 Query: 892 TENSLANENQQPIKSEPESEGEE 914 E L E +Q + E E + E Sbjct: 1860 EEQELWQEEEQKRRQERERKLRE 1882 Score = 48.5 bits (114), Expect = 4e-05 Identities = 47/219 (21%), Positives = 96/219 (43%), Gaps = 21/219 (9%) Query: 718 KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSD---DVHLRKKRK 774 +EQ++ R+ +E + + R E EE R + +++ + LRR+ + LR++++ Sbjct: 347 REQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 406 Query: 775 YEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPK 834 + Q+L ++L+ +E +L R++ + + L+R ++E D L Sbjct: 407 LRREQQLRREQQLR--REQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEET 464 Query: 835 TRESDHSRSSSPTAGPSTEGAEG-----PEEKKKVKMRRKRRLPNKE-------LSRELS 882 R R E E EE+++ + RR+++L ++ L R+ Sbjct: 465 ERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEE 524 Query: 883 KELNHEIQRTENSLANE----NQQPIKSEPESEGEEPKR 917 +E + R+E L E +Q +K E E E+ +R Sbjct: 525 EERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR 563 Score = 47.4 bits (111), Expect = 9e-05 Identities = 59/246 (23%), Positives = 102/246 (41%), Gaps = 48/246 (19%) Query: 718 KEQKMNRDNKE--GQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRK-KRK 774 K++K+ + ++ G+EP KRR + E R +E ++ + LLR + + ++ +R+ Sbjct: 962 KDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQE--EEQLLREEREKRRRQEWERQ 1019 Query: 775 YEKPQELSGRKR--LKPGKEDKLFRKKRRSWKN------------AEDRMALANKPLRR- 819 Y K EL + L+ +E + +++ R ++ E+R + L R Sbjct: 1020 YRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQ 1079 Query: 820 ------FKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLP 873 +QE E L E P K R + R E + EE+ + R KRR Sbjct: 1080 YRKEEELQQEEEQLLREEPEKRRRQERERQCR-----EEEELQQEEEQLLREEREKRR-- 1132 Query: 874 NKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLN 933 +EL R+ R E + E +Q ++ EPE KR ER +R + L Sbjct: 1133 RQELERQ---------YREEEEVQQEEEQLLREEPE------KRRRQELERQYREEEELQ 1177 Query: 934 GTPREL 939 +L Sbjct: 1178 QEEEQL 1183 Score = 47.0 bits (110), Expect = 1e-04 Identities = 53/228 (23%), Positives = 94/228 (41%), Gaps = 39/228 (17%) Query: 712 LPGSLLKEQKMNRDNKEG---QEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVH 768 L L KEQ++ ++ +E +E KRR + +E R+ +E + + LLR + + Sbjct: 895 LQEQLRKEQQLLQEEEEELQREEREKRRRQEQE--RQYREEEQLQQEEEQLLREEREKRR 952 Query: 769 LRKK-RKYEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDE 827 +++ R+Y K ++L ++ G+E + R++ R K E+ +QE E Sbjct: 953 RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREE---------EELQQEEEQL 1003 Query: 828 LPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNH 887 L E K R + R + + EE+ + R KRRL +E +EL Sbjct: 1004 LREEREKRRRQEWERQYR-----KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ 1058 Query: 888 EIQ-------------------RTENSLANENQQPIKSEPESEGEEPK 916 E + R E L E +Q ++ EPE + + Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQER 1106 Score = 46.6 bits (109), Expect = 2e-04 Identities = 47/213 (22%), Positives = 93/213 (43%), Gaps = 16/213 (7%) Query: 718 KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYE- 776 ++Q+ R ++ QE ++ E R+ +E ++ P + ++ LRK + E Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286 Query: 777 ---KPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPP 833 + +E ++RL+ +E +L RK+ + ++ + + ++ E +L Sbjct: 287 RRERQEEEQQQQRLR--REQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE 344 Query: 834 KTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRL-PNKELSRE----LSKELNHE 888 + RE R E EE+++ ++RR+++L ++L RE ++L E Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE 404 Query: 889 IQ-RTENSLANENQ----QPIKSEPESEGEEPK 916 Q R E L E Q Q ++ E E E E K Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQK 437 Score = 45.4 bits (106), Expect = 3e-04 Identities = 54/236 (22%), Positives = 95/236 (40%), Gaps = 20/236 (8%) Query: 718 KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEK 777 +E+++ + K E +R E E + ++ E K P + +S+ R+ + Y + Sbjct: 664 EEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESE-ADARQSKVYSR 722 Query: 778 PQELSGRKRLKPGKEDKLFRKKRRSWKNAE--DRMALANKPLRRF--------KQEPEDE 827 P++ G++R + +E + R+ W+ E R + R F K E + Sbjct: 723 PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ 782 Query: 828 LPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNH 887 A P RE R E PEE++K + RR+RR KEL E Sbjct: 783 RLSARPPLREQ-RERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQ---FLEEEE 838 Query: 888 EIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQL 943 ++QR E + QQ + E + ++ +R R ++ L + RH L Sbjct: 839 QLQRRERA-----QQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL 889 Score = 42.7 bits (99), Expect = 0.002 Identities = 39/187 (20%), Positives = 90/187 (48%), Gaps = 16/187 (8%) Query: 716 LLKEQKMNRDNKEGQ--EPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKK- 772 L +EQ++ R E + E + R E E+ RR + + +K+ + LR + ++ LR++ Sbjct: 1710 LQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERY-RKILEEEQLRPEREEQQLRRQE 1768 Query: 773 --RKYEKPQELSGRK---RLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPED- 826 RK+ + ++L + +L+ + D+ FR++ + + E++ + +++ E E Sbjct: 1769 RDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQL 1828 Query: 827 ELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPE------EKKKVKMRRKRRLPNKELSRE 880 +L E + R+ + + + E + E E++K + R+R+L + + R+ Sbjct: 1829 QLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQ 1888 Query: 881 LSKELNH 887 +E H Sbjct: 1889 QKEEQRH 1895 Score = 42.0 bits (97), Expect = 0.004 Identities = 51/219 (23%), Positives = 99/219 (45%), Gaps = 33/219 (15%) Query: 716 LLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSD---DVHLRKK 772 L +EQ++ R +E +RR + EE ++ ++ + LRR+ + + LR++ Sbjct: 300 LRREQQLRRKQEE-----ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRRE 354 Query: 773 RKYEKPQELSGRKRLKPGKEDKLFRKK--RRSWKNAEDRMALANKPLRRFKQ-EPEDELP 829 ++ E+ ++ R++ + +E +L R++ RR + ++ + LRR +Q E +L Sbjct: 355 QEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 414 Query: 830 EAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKE------LSRELSK 883 RE R E E E+K + RR++RL ++ L RE Sbjct: 415 REQQLRREQQLRR----------EQEEERHEQKHEQERREQRLKREQEERRDWLKREEET 464 Query: 884 ELNHEIQRTENSLANENQQP-----IKSEPESEGEEPKR 917 E HE +R + L + ++ +K E E E+ +R Sbjct: 465 E-RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER 502 Score = 41.6 bits (96), Expect = 0.005 Identities = 55/268 (20%), Positives = 109/268 (40%), Gaps = 14/268 (5%) Query: 690 KCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDE 749 +C + +Q R F+ +++K + ++ + + R EE + R + Sbjct: 1400 RCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQER 1459 Query: 750 HSKKVPPDGLLR-RKSDDVHLRKK-RKY-EKPQELSGRKRLKPGKEDKLFRKKRRSWKNA 806 H K + LL+ R+ +H +++ RK+ E+ Q+L ++R + +E +L ++ Sbjct: 1460 HRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519 Query: 807 EDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKM 866 E++ + R+F QE + + + R D R E E ++ + + Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREE--QQLSRQER 1577 Query: 867 RRKRRLPNKELSRELSKELNHEIQRTENSL-ANENQQPIKSEPESEGEE-----PKRPPG 920 RK RL +++ R+ E + E L E QQ ++ E + + E +R Sbjct: 1578 DRKFRLEEQKVRRQ---EQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQ 1634 Query: 921 ICERPHRFSKGLNGTPRELRHQLGPSLR 948 R R K L P+ R + LR Sbjct: 1635 QLHRQERDRKFLEEEPQLRRQEREQQLR 1662 Score = 41.2 bits (95), Expect = 0.006 Identities = 45/209 (21%), Positives = 88/209 (42%), Gaps = 29/209 (13%) Query: 716 LLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKY 775 L +EQ++ R+ +E + K E E +R E + D L R + + H +++RK Sbjct: 419 LRREQQLRREQEEERHEQKHEQERREQRLKREQEERR----DWLKREEETERHEQERRKQ 474 Query: 776 E--KPQELSGRKR-LKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPED----EL 828 + + QE R+R LK +E++ +++RR ++ ++E E+ L Sbjct: 475 QLKRDQEEERRERWLKLEEEERREQQERRE---------------QQLRREQEERREQRL 519 Query: 829 PEAPPKTRESDHSRSSSPTAGPSTEGAE---GPEEKKKVKMRRKRRLPNKELSRELSKEL 885 + R RS E E EE+K+++ R+ + +E + L Sbjct: 520 KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579 Query: 886 NHEIQRTENSLANENQQPIKSEPESEGEE 914 E +R + L E ++ ++ + E E Sbjct: 580 KREEERRQQRLKREQEERLEQRLKREEVE 608 Score = 40.8 bits (94), Expect = 0.008 Identities = 46/209 (22%), Positives = 88/209 (42%), Gaps = 23/209 (11%) Query: 715 SLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRK 774 SLL++++ D + EP R+ E E RRR R++ + + + Sbjct: 108 SLLQDRRQEEDQRRF-EPRDRQLEEEPGQRRRQK------------RQEQERELAEGEEQ 154 Query: 775 YEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPK 834 EK + L R R + ++++L+R+ R+ W+ E+R A + L+ K +E P+ Sbjct: 155 SEKQERLEQRDRQR--RDEELWRQ-RQEWQEREERRA-EEEQLQSCKGHETEEFPDEEQL 210 Query: 835 TRES-----DHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELS-RELSKELNHE 888 R R + EE++K +R+ L +E +E + E Sbjct: 211 RRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE 270 Query: 889 IQRTENSLANENQQPIKSEPESEGEEPKR 917 +Q E L +Q ++ E + E ++ +R Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQR 299 Score = 39.7 bits (91), Expect = 0.018 Identities = 53/244 (21%), Positives = 102/244 (41%), Gaps = 51/244 (20%) Query: 716 LLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPP---DGLLRRKSDDVHLRKK 772 L EQ++ R+ +E +E +R E + + R ++ K+ D LL+R+ + R++ Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE----RRQ 587 Query: 773 RKYEKPQELSGRKRLKPGKEDKLFRKKRRSWK---------------NAEDRMALANKPL 817 ++ ++ QE +RLK + ++L +++RR + +E++ + L Sbjct: 588 QRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQL 647 Query: 818 RR---------FKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRR 868 RR K+E E+E E K RE + R A EE+++ + R Sbjct: 648 RREQQERREQRLKREEEEERLEQRLK-REHEEERREQELA---------EEEQEQARERI 697 Query: 869 KRRLPNKELSRELSKELNH-----EIQRTENSLANENQQPIKSEPESEGEEPKRPPGICE 923 K R+P + E + ++ E + Q+ + ESE + + E Sbjct: 698 KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE-----E 752 Query: 924 RPHR 927 R HR Sbjct: 753 RAHR 756 Score = 39.3 bits (90), Expect = 0.024 Identities = 51/246 (20%), Positives = 103/246 (41%), Gaps = 27/246 (10%) Query: 686 WECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKE--GQEPAKRRSECEEAP 743 WE K N +G + L S L++++ +D + G++ + R E Sbjct: 1227 WEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDR----EQE 1282 Query: 744 RRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRKKRRSW 803 RRR + + P + L R+ R+ RK ++ ++L +R + + + RK R Sbjct: 1283 RRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEE 1342 Query: 804 KNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKK 863 + ++R +PLRR QE + + E + +E +G + EE+++ Sbjct: 1343 QLLQER---EEQPLRR--QERDRKFREEELRHQE---------------QGRKFLEEEQR 1382 Query: 864 VKMRRKRRLPNKELSRELSKELNHEI-QRTENSLANENQQPIKSEPESEGEEPKRPPGIC 922 ++ + + R KE + +E ++ Q + E QQ + E + + E ++ Sbjct: 1383 LRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ 1442 Query: 923 ERPHRF 928 ER +F Sbjct: 1443 ERERKF 1448 Score = 37.4 bits (85), Expect = 0.092 Identities = 44/212 (20%), Positives = 89/212 (41%), Gaps = 12/212 (5%) Query: 718 KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLR--KKRKY 775 ++ + RD K +E + E EE R + K + + LRR+ + LR + RK+ Sbjct: 1611 QQLRQERDRKF-REDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF 1669 Query: 776 EKPQEL---SGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAP 832 + ++L ++L+ + D+ FR++ + + E + + +QE E + E Sbjct: 1670 REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEE 1729 Query: 833 PKTRESDHS--RSSSPTAGPSTEGAEGP--EEKKKVKMRRKRRLPNKELSRELSKELNHE 888 +E++ R E P EE++ + R R+ +E R+ +E Sbjct: 1730 QLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLR 1789 Query: 889 IQRTENSLANENQQPIKSEPESEGEEPKRPPG 920 Q ++ E Q ++ E E + P++ G Sbjct: 1790 SQESDRKFREEEQ--LRQEREEQQLRPQQRDG 1819 Score = 34.7 bits (78), Expect = 0.59 Identities = 43/225 (19%), Positives = 90/225 (40%), Gaps = 18/225 (8%) Query: 718 KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEK 777 +EQ + ++ +R + E R ++ K + + LRR+ + RK K E+ Sbjct: 1341 EEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERE---RKFLKEEQ 1397 Query: 778 PQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRE 837 R++ D+ FR++ + E + + +QE E + E + R+ Sbjct: 1398 QLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQ 1457 Query: 838 SDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLA 897 H + EE++ ++ R +++L +E R+ +E +++R E Sbjct: 1458 ERHRKFR--------------EEEQLLQEREEQQLHRQERDRKFLEE-EQQLRRQERDRK 1502 Query: 898 NENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQ 942 Q+ EPE + E ++ +R +F + R+ R Q Sbjct: 1503 FREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQ 1547 >gi|74272284 membrane associated guanylate kinase, WW and PDZ domain containing 1 isoform c [Homo sapiens] Length = 1462 Score = 51.6 bits (122), Expect = 5e-06 Identities = 66/314 (21%), Positives = 114/314 (36%), Gaps = 40/314 (12%) Query: 634 CGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKI----KESEGVVNDELPNCWECP 689 CG+ D + E G+ M+ S E+I G ++ K +G V + P+ Sbjct: 1161 CGKMRIGDEILEINGE-TTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPS----- 1214 Query: 690 KCNHAGKTGKQ-----KRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPR 744 H TG Q + GP + +L S + + + E + A+ E R Sbjct: 1215 SDRHGPATGPQGVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYSR 1274 Query: 745 RRSDEHS----KKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRKKR 800 + ++ H+ + P G R K R+ + E+ +G KR P K+R Sbjct: 1275 QPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQAERAAAANGPKRRSP-------EKRR 1327 Query: 801 RSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSS-------SPTAGPSTE 853 ++A++ + K +R PE +P + R+ SR P Sbjct: 1328 EGTRSADNTLERREKHEKRRDVSPERRRERSPTRRRDGSPSRRRRSLERLLEQRRSPERR 1387 Query: 854 GAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGE 913 PE + K RR+ R P + R L K R A+ ++ + + G Sbjct: 1388 RGGSPERRAKSTDRRRARSPERRRERSLDK-------RNREDRASHREREEANLKQDAGR 1440 Query: 914 EPKRPPGICERPHR 927 + PP RP++ Sbjct: 1441 SSRHPPEQRRRPYK 1454 >gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] Length = 245 Score = 51.2 bits (121), Expect = 6e-06 Identities = 53/239 (22%), Positives = 98/239 (41%), Gaps = 19/239 (7%) Query: 691 CNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEH 750 C+H K Q PG++ ++ +K + +E + +RR E E+ R R E Sbjct: 22 CSHISKPCTQ---PGWQSEIREREREIETRKEGKKERESERKKERR-EREKRKREREKER 77 Query: 751 SKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRM 810 ++ R K + RKK + E+ + R+R K KE + K+++ K R Sbjct: 78 KRE-------RGKKEKKGERKKEERERKK----RRREKENKEGEEKEKRKKKEKKERGRT 126 Query: 811 ALANKPLRRFKQEPEDELPEAPPKT--RESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRR 868 + K R ++ +E E K RE + R G + E K+K + R Sbjct: 127 SKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKER 186 Query: 869 KRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHR 927 K+R N++ ++ + ++ E E ++ + + ++ E +R G ER R Sbjct: 187 KKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKER--GKRERKER 243 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.134 0.412 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 58,112,553 Number of Sequences: 37866 Number of extensions: 3188106 Number of successful extensions: 23801 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 157 Number of HSP's successfully gapped in prelim test: 732 Number of HSP's that attempted gapping in prelim test: 18187 Number of HSP's gapped (non-prelim): 5145 length of query: 1265 length of database: 18,247,518 effective HSP length: 114 effective length of query: 1151 effective length of database: 13,930,794 effective search space: 16034343894 effective search space used: 16034343894 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.