Guide to the Human Genome
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Search of human proteins with 54112380

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|54112380 F-box and leucine-rich repeat protein 10 isoform b
[Homo sapiens]
         (1265 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [...  2614   0.0  
gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [...  2544   0.0  
gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens]  1116   0.0  
gi|157168349 F-box and leucine-rich repeat protein 19 [Homo sapi...   594   e-169
gi|32698700 PHD finger protein 8 [Homo sapiens]                       291   3e-78
gi|90093355 jumonji C domain containing histone demethylase 1 ho...   274   3e-73
gi|117190342 PHD finger protein 2 [Homo sapiens]                      248   3e-65
gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens]    78   6e-14
gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens]     71   7e-12
gi|156142182 CXXC finger 1 (PHD domain) isoform 1 [Homo sapiens]       67   1e-10
gi|156142180 CXXC finger 1 (PHD domain) isoform 2 [Homo sapiens]       67   1e-10
gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens]      66   2e-10
gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens]    64   1e-09
gi|195927037 DNA (cytosine-5-)-methyltransferase 1 isoform a [Ho...    62   3e-09
gi|4503351 DNA (cytosine-5-)-methyltransferase 1 isoform b [Homo...    62   3e-09
gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens]    60   2e-08
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]         59   3e-08
gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2 ...    59   4e-08
gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1 ...    59   4e-08
gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo ...    57   9e-08
gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo ...    57   9e-08
gi|21464115 methyl-CpG binding domain protein 1 isoform 2 [Homo ...    55   4e-07
gi|21464119 methyl-CpG binding domain protein 1 isoform PCM1 [Ho...    55   4e-07
gi|21464117 methyl-CpG binding domain protein 1 isoform 1 [Homo ...    55   4e-07
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa...    55   6e-07
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]            54   7e-07
gi|55741709 RNA binding motif protein 25 [Homo sapiens]                54   1e-06
gi|148746195 trichohyalin [Homo sapiens]                               54   1e-06
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom...    52   5e-06
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]            51   6e-06

>gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [Homo
            sapiens]
          Length = 1265

 Score = 2614 bits (6775), Expect = 0.0
 Identities = 1265/1265 (100%), Positives = 1265/1265 (100%)

Query: 1    MEAEKDSGRRLRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKD 60
            MEAEKDSGRRLRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKD
Sbjct: 1    MEAEKDSGRRLRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKD 60

Query: 61   FNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEM 120
            FNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEM
Sbjct: 61   FNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEM 120

Query: 121  SMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQ 180
            SMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQ
Sbjct: 121  SMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQ 180

Query: 181  TEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNL 240
            TEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNL
Sbjct: 181  TEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNL 240

Query: 241  ALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILH 300
            ALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILH
Sbjct: 241  ALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILH 300

Query: 301  SFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLI 360
            SFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLI
Sbjct: 301  SFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLI 360

Query: 361  DAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPS 420
            DAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPS
Sbjct: 361  DAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPS 420

Query: 421  EDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTE 480
            EDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTE
Sbjct: 421  EDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTE 480

Query: 481  FELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVT 540
            FELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVT
Sbjct: 481  FELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVT 540

Query: 541  WPKKTPKNRAVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCK 600
            WPKKTPKNRAVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCK
Sbjct: 541  WPKKTPKNRAVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCK 600

Query: 601  DMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSIC 660
            DMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSIC
Sbjct: 601  DMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSIC 660

Query: 661  NEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQ 720
            NEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQ
Sbjct: 661  NEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQ 720

Query: 721  KMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQE 780
            KMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQE
Sbjct: 721  KMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQE 780

Query: 781  LSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDH 840
            LSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDH
Sbjct: 781  LSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDH 840

Query: 841  SRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANEN 900
            SRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANEN
Sbjct: 841  SRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANEN 900

Query: 901  QQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPS 960
            QQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPS
Sbjct: 901  QQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPS 960

Query: 961  VSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCMRVC 1020
            VSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCMRVC
Sbjct: 961  VSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCMRVC 1020

Query: 1021 RTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLP 1080
            RTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLP
Sbjct: 1021 RTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLP 1080

Query: 1081 GLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNR 1140
            GLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNR
Sbjct: 1081 GLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNR 1140

Query: 1141 SKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDS 1200
            SKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDS
Sbjct: 1141 SKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDS 1200

Query: 1201 LTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSSFQGRSCSTT 1260
            LTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSSFQGRSCSTT
Sbjct: 1201 LTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSSFQGRSCSTT 1260

Query: 1261 RLGDE 1265
            RLGDE
Sbjct: 1261 RLGDE 1265


>gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [Homo
            sapiens]
          Length = 1336

 Score = 2544 bits (6593), Expect = 0.0
 Identities = 1239/1277 (97%), Positives = 1239/1277 (97%), Gaps = 38/1277 (2%)

Query: 12   RPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREAL 71
            RPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREAL
Sbjct: 43   RPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREAL 102

Query: 72   RVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYET 131
            RVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYET
Sbjct: 103  RVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYET 162

Query: 132  PEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMK 191
            PEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMK
Sbjct: 163  PEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMK 222

Query: 192  YPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGK 251
            YPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGK
Sbjct: 223  YPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGK 282

Query: 252  QSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIY 311
            QSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIY
Sbjct: 283  QSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIY 342

Query: 312  EIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGF 371
            EIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGF
Sbjct: 343  EIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGF 402

Query: 372  SSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPK 431
            SSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPK
Sbjct: 403  SSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPK 462

Query: 432  APALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVE 491
            APALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVE
Sbjct: 463  APALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVE 522

Query: 492  KLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAV 551
            KLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAV
Sbjct: 523  KLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAV 582

Query: 552  GRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRM 611
            GRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRM
Sbjct: 583  GRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRM 642

Query: 612  KQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKI 671
            KQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKI
Sbjct: 643  KQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKI 702

Query: 672  KESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQE 731
            KESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQE
Sbjct: 703  KESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQE 762

Query: 732  PAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKR----- 786
            PAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKR     
Sbjct: 763  PAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRASSLQ 822

Query: 787  ---------------------------------LKPGKEDKLFRKKRRSWKNAEDRMALA 813
                                             LKPGKEDKLFRKKRRSWKNAEDRMALA
Sbjct: 823  TSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRMALA 882

Query: 814  NKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLP 873
            NKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLP
Sbjct: 883  NKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLP 942

Query: 874  NKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLN 933
            NKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLN
Sbjct: 943  NKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLN 1002

Query: 934  GTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAA 993
            GTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAA
Sbjct: 1003 GTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAA 1062

Query: 994  HVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGII 1053
            HVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGII
Sbjct: 1063 HVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGII 1122

Query: 1054 RRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQW 1113
            RRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQW
Sbjct: 1123 RRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQW 1182

Query: 1114 VEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSK 1173
            VEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSK
Sbjct: 1183 VEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSK 1242

Query: 1174 LHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRY 1233
            LHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRY
Sbjct: 1243 LHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRY 1302

Query: 1234 CKQVTKEGCEQFIAEMS 1250
            CKQVTKEGCEQFIAEMS
Sbjct: 1303 CKQVTKEGCEQFIAEMS 1319


>gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens]
          Length = 1162

 Score = 1116 bits (2886), Expect = 0.0
 Identities = 631/1289 (48%), Positives = 803/1289 (62%), Gaps = 183/1289 (14%)

Query: 1    MEAEKDSGR---RLRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAME 57
            ME E++  R   RLR   R+RY E++ +SD +EI   R F LEEKL +  Y  +FV  ME
Sbjct: 1    MEPEEERIRYSQRLRGTMRRRY-EDDGISD-DEIEGKRTFDLEEKLHTNKYNANFVTFME 58

Query: 58   GKDFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKG 117
            GKDFN EY+QR  LR PLIF+  DGLGIKMPDPDFTV DVK+ VGSRR+VDVMDVNTQKG
Sbjct: 59   GKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKG 118

Query: 118  TEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLK 177
             EM+M+Q+ RYYETPE +R+KLYNVISLEFSHT+LE++V+RP+ VD +DWVDNMWP+HLK
Sbjct: 119  IEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLK 178

Query: 178  EKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTL 237
            E QTE+TNAI EM+YPKV+KYCLMSV+GC+TDFH+DFGGTSVWYH+ +GGK+FWLIPPT 
Sbjct: 179  ESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTA 238

Query: 238  HNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGN 297
            HNL LYE W+LSGKQ DIFLGDRV  CQRIELKQGYTF IPSGWIHAVYTP D+LVFGGN
Sbjct: 239  HNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGN 298

Query: 298  ILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRES 357
             LHSFN+PMQL+IY IEDRTRV  KFRYPFYYEMCWYVLERYVYC+T RSHLT+E+Q+ES
Sbjct: 299  FLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKES 358

Query: 358  MLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTS 417
            + +D      ++G  S +    +EEA D++P+    +      R     P  +G      
Sbjct: 359  LSMDL----ELNGLESGNG---DEEAVDREPRRLSSR------RSVLTSPVANGVNL--- 402

Query: 418  TPSEDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTH 477
                D + LGK  ++  L  LK+TL+ +S     S          P  +P  +   +  H
Sbjct: 403  ----DYDGLGKTCRS--LPSLKKTLAGDSSSDC-SRGSHNGQVWDPQCAPRKD---RQVH 452

Query: 478  LTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVP 537
            LT FEL+GL+ LV+KLESLP +KKCVP GIED  AL+  VK +L+E A+ DP LA+TGVP
Sbjct: 453  LTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVP 512

Query: 538  VVTWPKKTPKNRAVGRPKGKLGPASAVK---------------LAANRTTAGARRRRTRC 582
            +V WPK+  K +   RPK ++      K                AA+   +GARRRR RC
Sbjct: 513  IVQWPKRD-KLKFPTRPKVRVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARRRRVRC 571

Query: 583  RKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDT 642
            RKC+AC++ ECG CH+C+DMKKFGGPGRMKQSC++RQC+AP LPH+              
Sbjct: 572  RKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVT------------ 619

Query: 643  VEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKR 702
                          CS+C E+         E       +L  C  C +  H G    Q  
Sbjct: 620  --------------CSLCGEVDQ------NEETQDFEKKLMECCICNEIVHPGCL--QMD 657

Query: 703  GPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRR 762
            G G          LL E+  N               C E P+   ++ S+K         
Sbjct: 658  GEG----------LLNEELPN---------------CWECPKCYQEDSSEKA-------- 684

Query: 763  KSDDVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQ 822
                   +K++  E  +E    K L+P                    +   ++PL     
Sbjct: 685  -------QKRKMEESDEEAVQAKVLRP--------------------LRSCDEPLTPPPH 717

Query: 823  EPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELS 882
             P   L               SSP AGPS   +   +E+ K           ++L R   
Sbjct: 718  SPTSMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFK----------RRQLLR--- 764

Query: 883  KELNHEIQRTENSLANENQQPIKSEPE-SEGEEPK-RPPGICERPHRFSKGLNGTPRELR 940
                  +Q TE ++  E +     + E SE E+ K R   +     R +K L+GT    +
Sbjct: 765  ------LQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPK 818

Query: 941  HQL----GPSLRSPPRVISRPPPSVSPPKCIQM--------ERHVIRPPPISPPPDSLPL 988
             Q       +LR  PRV+ +  P+ +P +  +         E         +    +  L
Sbjct: 819  LQAITASSANLRHSPRVLVQHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARL 878

Query: 989  D-------DGAAHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHC 1041
            +       DG    M REVWM+VF YLS ++LC CMRVC+TW +WCCDKRLWT+IDL+ C
Sbjct: 879  NGRGSWAQDGDESWMQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRC 938

Query: 1042 KSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSS 1101
            K+I P  LSGII+RQPVSLDLSWTNISKKQL+WL+NRLPGL+DL+L+GCSW AVSAL +S
Sbjct: 939  KAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTS 998

Query: 1102 SCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASL 1161
            SCPLLRTLD++W  G+KD Q+RDLL+PP D +PGQ DNRSKLRN+ + RLAGLDITDA+L
Sbjct: 999  SCPLLRTLDLRWAVGIKDPQIRDLLTPPAD-KPGQ-DNRSKLRNMTDFRLAGLDITDATL 1056

Query: 1162 RLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFK 1221
            RLIIRHMPLLS+L LS+C+H+TDQS NLLTAVG++TR SLTE+N++ CNK+TDQ L + +
Sbjct: 1057 RLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLR 1116

Query: 1222 RCGNICHIDLRYCKQVTKEGCEQFIAEMS 1250
            R  N+  IDLR CKQ+T++ CE FI+++S
Sbjct: 1117 RIANVTLIDLRGCKQITRKACEHFISDLS 1145


>gi|157168349 F-box and leucine-rich repeat protein 19 [Homo sapiens]
          Length = 694

 Score =  594 bits (1531), Expect = e-169
 Identities = 318/710 (44%), Positives = 429/710 (60%), Gaps = 59/710 (8%)

Query: 555  KGKLGPASAVKLAANRTT----AGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGR 610
            KG+ GP++ +    + ++    AGARRRRTRCR+C AC+RTECG+CHFC+DMKKFGGPGR
Sbjct: 8    KGESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGR 67

Query: 611  MKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLK 670
            MKQSC++RQC APVLPHTAVCL+CGEAGKEDTVE EE KF L LMEC+ICNEI+HPGCLK
Sbjct: 68   MKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVHPGCLK 127

Query: 671  IKESEGVVNDELPNCWECPKCNHAGKTGKQK-RGPGFKYASNLP--GSLLKEQKMNRD-- 725
            + ++EGV+N E+PNCWECP+C   G+T K    GPG + A N     SL    K+  +  
Sbjct: 128  MGKAEGVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPP 187

Query: 726  ------NKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQ 779
                   ++G  PA    E    P +R +  +   PP             RKK K  + +
Sbjct: 188  LPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTP-----------RKKVKGGRER 236

Query: 780  ELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESD 839
             L      K G +  L R              L   P + F        P  PP+  E  
Sbjct: 237  HLK-----KVGGDACLLRGSDPGGPGLLPPRVL--NPSQAFSSCH----PGLPPENWEKP 285

Query: 840  HSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANE 899
                      P    AEGP        R K          E  K +   ++R  ++ ++ 
Sbjct: 286  K---------PPLASAEGPAVPSPSPQREKL---------ERFKRMCQLLERVPDTSSSS 327

Query: 900  NQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTP--RELRHQLGPSLRSPPRVISRP 957
            +     S+           PG      R ++G +G    R  R  + P    P  ++S P
Sbjct: 328  SDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAVRPGSGGP--LLSWP 385

Query: 958  PPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCM 1017
                 PP+  Q+ERHV+RPPP SP PD+LPL  G+ H + R  W+ VF +L  ++LC+CM
Sbjct: 386  LGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCICM 445

Query: 1018 RVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLIN 1077
            RVCRTW+RWC DKRLW R+DL+  KS+TP MLSG++RRQP +LDLSWT +SKKQL WL+N
Sbjct: 446  RVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLN 505

Query: 1078 RLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQM 1137
            RL GL++LVLSGCSW++VSAL S+  P LR LD++W+E +KD+Q+R+LL PP D +PGQ 
Sbjct: 506  RLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQT 565

Query: 1138 DNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTT 1197
            ++R +L+ + ELRLAGL++TDASLRL++RH P LS L LS+C HV D S++LLTA  +  
Sbjct: 566  ESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPL 625

Query: 1198 RDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIA 1247
            R++L  +NL+ C+++TD CL  F+RC  +  +DLR C+Q++ E C +  A
Sbjct: 626  RETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCRQLSPEACARLAA 675


>gi|32698700 PHD finger protein 8 [Homo sapiens]
          Length = 1024

 Score =  291 bits (745), Expect = 3e-78
 Identities = 140/296 (47%), Positives = 194/296 (65%), Gaps = 16/296 (5%)

Query: 42  KLRSQLYQG--DFVHAMEGKDFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKL 99
           +LRS+ +    + +    G     E+++  +  VP++  +KDGLG+ +P P FTVRDV+ 
Sbjct: 90  ELRSRTFDSSDEVILKPTGNQLTVEFLEENSFSVPILVLKKDGLGMTLPSPSFTVRDVEH 149

Query: 100 LVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRP 159
            VGS + +DV+DV  Q   +M +  FV+YY +   +R+K+ NVISLEFS T+L +LV+ P
Sbjct: 150 YVGSDKEIDVIDVTRQADCKMKLGDFVKYYYS--GKREKVLNVISLEFSDTRLSNLVETP 207

Query: 160 TVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSV 219
            +V  + WV+N+WP+                + P V+KYCLMSV+  +TDFHIDFGGTSV
Sbjct: 208 KIVRKLSWVENLWPEE------------CVFERPNVQKYCLMSVRDSYTDFHIDFGGTSV 255

Query: 220 WYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPS 279
           WYHV +G KIF+LI PT  NL L+E W  S  Q+++F GD+V++C +  +KQG T FIP+
Sbjct: 256 WYHVLKGEKIFYLIRPTNANLTLFECWSSSSNQNEMFFGDQVDKCYKCSVKQGQTLFIPT 315

Query: 280 GWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYV 335
           GWIHAV TPVD L FGGN LHS N+ MQL+ YEIE R      FR+P +  +CWYV
Sbjct: 316 GWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFRFPNFETICWYV 371



 Score = 31.2 bits (69), Expect = 6.6
 Identities = 14/52 (26%), Positives = 25/52 (48%), Gaps = 6/52 (11%)

Query: 654 LMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCN--HAGKTGKQKRG 703
           ++EC +C +  H  C+ ++E +    D     + CP C   H     K++RG
Sbjct: 20  MIECDMCQDWFHGSCVGVEEEKAADID----LYHCPNCEVLHGPSIMKKRRG 67


>gi|90093355 jumonji C domain containing histone demethylase 1
           homolog D [Homo sapiens]
          Length = 941

 Score =  274 bits (701), Expect = 3e-73
 Identities = 134/320 (41%), Positives = 198/320 (61%), Gaps = 17/320 (5%)

Query: 18  RYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQG--DFVHAMEGKDFNYEYVQREALRVPL 75
           R+D  E + D  + V     +  ++LRS+++    + +  M G      Y+++    VP+
Sbjct: 102 RHDYTE-IDDGSKPVQAGTRTFIKELRSRVFPSADEIIIKMHGSQLTQRYLEKHGFDVPI 160

Query: 76  IFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQ 135
           +  + D LG+++P P F+V DV+  VG  +++DV+DV  Q  ++M++  +V+Y+  P   
Sbjct: 161 MVPKLDDLGLRLPSPTFSVMDVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFMNPN-- 218

Query: 136 RDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKV 195
           R K+ NVISLEFS TK+  LV+ P +   + WV+N WP              +    P V
Sbjct: 219 RPKVLNVISLEFSDTKMSELVEVPDIAKKLSWVENYWPDD------------SVFPKPFV 266

Query: 196 KKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDI 255
           +KYCLM V+  +TDFHIDFGGTSVWYHV  G KIF+LI PT  NLA YE W  S  QS++
Sbjct: 267 QKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTDENLARYESWSSSVTQSEV 326

Query: 256 FLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIED 315
           F GD+V++C +  +KQG+T F+P+GWIHAV T  D + FGGN LH+ N+ MQLR YE+E 
Sbjct: 327 FFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEK 386

Query: 316 RTRVQPKFRYPFYYEMCWYV 335
           R +    F++PF+  +CW+V
Sbjct: 387 RLKTPDLFKFPFFEAICWFV 406



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 16/54 (29%), Positives = 25/54 (46%), Gaps = 6/54 (11%)

Query: 651 NLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCN--HAGKTGKQKR 702
           N  ++EC IC +  H  C+ ++E   V  D     + CP C   H     K++R
Sbjct: 49  NRFMIECDICKDWFHGSCVGVEEHHAVDID----LYHCPNCAVLHGSSLMKKRR 98


>gi|117190342 PHD finger protein 2 [Homo sapiens]
          Length = 1096

 Score =  248 bits (632), Expect = 3e-65
 Identities = 123/297 (41%), Positives = 175/297 (58%), Gaps = 16/297 (5%)

Query: 41  EKLRSQLYQG--DFVHAMEGKDFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVK 98
           ++LRS+ +    D V  + G      Y++      P++  +KDGLG+ +P P F V DV+
Sbjct: 91  KELRSRTFPSAEDVVARVPGSQLTLGYMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVE 150

Query: 99  LLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKR 158
             VG  R VDV DV  QK  +M + +FV YY +    R ++ NV +LEFS T++   V+ 
Sbjct: 151 NYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYS--TNRKRVLNVTNLEFSDTRMSSFVEP 208

Query: 159 PTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTS 218
           P +V  + WV+N WP              A +  PKV KYCL+ VK  +TDFHID GG S
Sbjct: 209 PDIVKKLSWVENYWPDD------------ALLAKPKVTKYCLICVKDSYTDFHIDSGGAS 256

Query: 219 VWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIP 278
            WYHV +G K F+LI P   N++LYE W  +   S++F  D+V++C +  +KQG T FIP
Sbjct: 257 AWYHVLKGEKTFYLIRPASANISLYERWRSASNHSEMFFADQVDKCYKCIVKQGQTLFIP 316

Query: 279 SGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYV 335
           SGWI+A  TPVD L F G+ LHS +V MQ+R YE+E R ++    ++P +   CWY+
Sbjct: 317 SGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYM 373



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 19/59 (32%), Positives = 27/59 (45%), Gaps = 11/59 (18%)

Query: 654 LMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKC--NHAGKTGKQKR-----GPG 705
           ++EC  C +  H  C+ ++E E    D     + CP C   H   T K+KR     GPG
Sbjct: 20  MIECDACKDWFHGSCVGVEEEEAPDID----IYHCPNCEKTHGKSTLKKKRTWHKHGPG 74



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 36/137 (26%), Positives = 55/137 (40%), Gaps = 27/137 (19%)

Query: 861 KKKVKMRRKRRLPNKELSRELSKELNHEIQRTEN---SLANENQQPIKSEPESEGE-EPK 916
           KK+     +  LP      +L K+L  EI+ +EN   ++  E      S+   +G+ E +
Sbjct: 411 KKQALAEHEDELPEHFKPSQLIKDLAKEIRLSENASKAVRPEVNTVASSDEVCDGDREKE 470

Query: 917 RPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPS--VSPPKCIQMERHVI 974
            PP   E            P+ L  ++  S +  P+ +  P PS    PPK         
Sbjct: 471 EPPSPIEAT---------PPQSLLEKV--SKKKTPKTVKMPKPSKIPKPPK--------- 510

Query: 975 RPPPISPPPDSLPLDDG 991
            PP    PP +L L DG
Sbjct: 511 -PPKPPRPPKTLKLKDG 526


>gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens]
          Length = 436

 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 75/269 (27%), Positives = 117/269 (43%), Gaps = 48/269 (17%)

Query: 1020 CRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPV--SLDLSWTN-ISKKQLSWLI 1076
            C + +++C   R    +DL  C SIT + L  +    P+   L++SW + ++K  +  L+
Sbjct: 135  CTSLSKFCSKLR---HLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALV 191

Query: 1077 NRLPGLRDLVLSGCSWIAVSAL--CSSSCPLLRTLDVQWVEGLKDAQMRDLL-------- 1126
                GL+ L L GC+ +   AL    + CP L TL++Q    + D  +  +         
Sbjct: 192  RGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQS 251

Query: 1127 ------SPPTD---NRPGQMDNRSKL------------------RNIVELRLAGLD---- 1155
                  S  TD   N  GQ   R ++                  RN  EL    L+    
Sbjct: 252  LCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQ 311

Query: 1156 ITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQ 1215
            ITD++L  +  H P L  L LS+C  +TD  I  L   G    D L  I L +C  +TD 
Sbjct: 312  ITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHL-GNGACAHDQLEVIELDNCPLITDA 370

Query: 1216 CLSFFKRCGNICHIDLRYCKQVTKEGCEQ 1244
             L   K C ++  I+L  C+Q+T+ G ++
Sbjct: 371  SLEHLKSCHSLERIELYDCQQITRAGIKR 399



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 68/249 (27%), Positives = 106/249 (42%), Gaps = 45/249 (18%)

Query: 998  REVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDL-NHCKSITPLMLSGIIRRQ 1056
            +E+ + +FS+L    LC C +V R WN    D   W RIDL +  + I   ++       
Sbjct: 30   KELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVE------ 83

Query: 1057 PVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSAL--CSSSCPLLRTLDVQWV 1114
                     NISK+   +       LR L L GC  +  +AL   + +C  +  L++   
Sbjct: 84   ---------NISKRCGGF-------LRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGC 127

Query: 1115 EGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAG-LDITDASLRLIIRHMPLLSK 1173
                DA    L               SKLR+   L LA    IT+ SL+ +    PLL +
Sbjct: 128  TKTTDATCTSL-----------SKFCSKLRH---LDLASCTSITNMSLKALSEGCPLLEQ 173

Query: 1174 LHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFF-KRCGNICHIDLR 1232
            L++S+C+ VT   I  L          L  + L  C ++ D+ L +    C  +  ++L+
Sbjct: 174  LNISWCDQVTKDGIQAL----VRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQ 229

Query: 1233 YCKQVTKEG 1241
             C Q+T EG
Sbjct: 230  TCLQITDEG 238


>gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens]
          Length = 423

 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 76/290 (26%), Positives = 119/290 (41%), Gaps = 52/290 (17%)

Query: 1008 LSHQDLCVCMRV----CRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIR--RQPVSLD 1061
            + H +L  C ++    C + +R+C   +    +DL  C SIT   L GI    R    L+
Sbjct: 106  IEHLNLNGCTKITDSTCYSLSRFCSKLK---HLDLTSCVSITNSSLKGISEGCRNLEYLN 162

Query: 1062 LSWTN-ISKKQLSWLINRLPGLRDLVLSGCSWIAVSAL-----------------CSS-- 1101
            LSW + I+K  +  L+    GL+ L+L GC+ +   AL                 CS   
Sbjct: 163  LSWCDQITKDGIEALVRGCRGLKALLLRGCTQLEDEALKHIQNYCHELVSLNLQSCSRIT 222

Query: 1102 ---------SCPLLRTLDVQWVEGLKDAQMRDL---------LSPPTDNRPGQMDNRSKL 1143
                      C  L+ L +     L DA +  L         L     +           
Sbjct: 223  DEGVVQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRLQILEAARCSHLTDAGFTLLA 282

Query: 1144 RNIVELRLAGLD----ITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRD 1199
            RN  EL    L+    ITD++L  +  H P L  L LS+C  +TD  I L  +  T   +
Sbjct: 283  RNCHELEKMDLEECILITDSTLIQLSIHCPKLQALSLSHCELITDDGI-LHLSNSTCGHE 341

Query: 1200 SLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEM 1249
             L  + L +C  +TD  L   + C  +  ++L  C+QVT+ G ++  A++
Sbjct: 342  RLRVLELDNCLLITDVALEHLENCRGLERLELYDCQQVTRAGIKRMRAQL 391



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 56/251 (22%), Positives = 102/251 (40%), Gaps = 29/251 (11%)

Query: 998  REVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDL-NHCKSITPLMLSGIIRR- 1055
            +E+ + +FS+L    LC C ++ + WN    D   W RIDL N    +   ++  I +R 
Sbjct: 17   KELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFNFQIDVEGRVVENISKRC 76

Query: 1056 ----QPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSS--CPLLRTL 1109
                + +SL      +    L         +  L L+GC+ I  S   S S  C  L+ L
Sbjct: 77   GGFLRKLSL-RGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHL 135

Query: 1110 DVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLD-ITDASLRLIIRHM 1168
            D+     + ++ ++ +                  RN+  L L+  D IT   +  ++R  
Sbjct: 136  DLTSCVSITNSSLKGI--------------SEGCRNLEYLNLSWCDQITKDGIEALVRGC 181

Query: 1169 PLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQ-CLSFFKRCGNIC 1227
              L  L L  C  + D+++  +          L  +NL  C+++TD+  +   + C  + 
Sbjct: 182  RGLKALLLRGCTQLEDEALKHI----QNYCHELVSLNLQSCSRITDEGVVQICRGCHRLQ 237

Query: 1228 HIDLRYCKQVT 1238
             + L  C  +T
Sbjct: 238  ALCLSGCSNLT 248



 Score = 31.2 bits (69), Expect = 6.6
 Identities = 18/61 (29%), Positives = 31/61 (50%), Gaps = 4/61 (6%)

Query: 1201 LTEINLSDCNKVTDQCL-SFFKRCGNICHIDLRYCKQVTKEGC---EQFIAEMSSFQGRS 1256
            L +++L  C  V D  L +F + C NI H++L  C ++T   C    +F +++      S
Sbjct: 80   LRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHLDLTS 139

Query: 1257 C 1257
            C
Sbjct: 140  C 140


>gi|156142182 CXXC finger 1 (PHD domain) isoform 1 [Homo sapiens]
          Length = 660

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 27/46 (58%), Positives = 34/46 (73%), Gaps = 1/46 (2%)

Query: 576 RRRRTRCRKCEACLRTE-CGECHFCKDMKKFGGPGRMKQSCIMRQC 620
           +R    C +CEAC RTE CG C FC+DMKKFGGP +++Q C +RQC
Sbjct: 163 KRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQC 208


>gi|156142180 CXXC finger 1 (PHD domain) isoform 2 [Homo sapiens]
          Length = 656

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 27/46 (58%), Positives = 34/46 (73%), Gaps = 1/46 (2%)

Query: 576 RRRRTRCRKCEACLRTE-CGECHFCKDMKKFGGPGRMKQSCIMRQC 620
           +R    C +CEAC RTE CG C FC+DMKKFGGP +++Q C +RQC
Sbjct: 163 KRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQC 208


>gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens]
          Length = 491

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 85/328 (25%), Positives = 126/328 (38%), Gaps = 52/328 (15%)

Query: 953  VISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQD 1012
            V S PP  ++ P    + R   RP       D LP      H M     + +FS+L    
Sbjct: 88   VHSPPPTRLTHP----LIRLASRPQKEQASIDRLP-----DHSM-----VQIFSFLPTNQ 133

Query: 1013 LCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRR-----QPVSLDLSWTNI 1067
            LC C RVCR W     D RLW  I L          L  + RR       V L L    +
Sbjct: 134  LCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVTV 193

Query: 1068 S------KKQLSWLINRLPGLRDLVLSGCSWIAVSALCS--SSCPLLRTLDVQWVEGLKD 1119
            S       + L  +    P LR L +SGC  I+  A+    S CP L  LDV     +  
Sbjct: 194  SGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTC 253

Query: 1120 AQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDA------SLRLIIRHMPLLSK 1173
              +    S       G+           ++ +  LD+TD        L  I  H   L+ 
Sbjct: 254  ISLTREASIKLSPLHGK-----------QISIRYLDMTDCFVLEDEGLHTIAAHCTQLTH 302

Query: 1174 LHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCL-SFFKRCGNICHIDLR 1232
            L+L  C  +TD+ +  L         S+ E+++SDC  V+D  L    K    + ++ + 
Sbjct: 303  LYLRRCVRLTDEGLRYLVIYCA----SIKELSVSDCRFVSDFGLREIAKLESRLRYLSIA 358

Query: 1233 YCKQVTKEGCE---QFIAEMSSFQGRSC 1257
            +C +VT  G     ++ +++     R C
Sbjct: 359  HCGRVTDVGIRYVAKYCSKLRYLNARGC 386


>gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens]
          Length = 418

 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 68/272 (25%), Positives = 114/272 (41%), Gaps = 32/272 (11%)

Query: 999  EVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLN-HCKSITP-----LMLSGI 1052
            E+   +F YL  +D     +VC  W      K +W  ++   H +   P     L   GI
Sbjct: 11   ELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGI 70

Query: 1053 IRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQ 1112
             R Q +SL        ++ LS++I  +  +  L LSGC  +  + L  +         VQ
Sbjct: 71   RRVQILSL--------RRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAF--------VQ 114

Query: 1113 WVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGL-DITDASLRLIIRHMPLL 1171
             +  L+   +  L    TD+  G++     L+ +  L L G  +IT+  L LI   +  L
Sbjct: 115  EIGSLRALNL-SLCKQITDSSLGRI--AQYLKGLEVLELGGCSNITNTGLLLIAWGLQRL 171

Query: 1172 SKLHLSYCNHVTDQSINLLTAVGTTTRD---SLTEINLSDCNKVTDQCLSFFKR-CGNIC 1227
              L+L  C H++D  I  L  +  +  +    L ++ L DC K+TD  L    R    + 
Sbjct: 172  KSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLR 231

Query: 1228 HIDLRYCKQVTKEGCEQF--IAEMSSFQGRSC 1257
             ++L +C  ++  G      +  + S   RSC
Sbjct: 232  LLNLSFCGGISDAGLLHLSHMGSLRSLNLRSC 263



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 56/219 (25%), Positives = 94/219 (42%), Gaps = 37/219 (16%)

Query: 1036 IDLNHCKSITPLMLSGIIRRQPVSLD--LSWTNISKKQLSWLINRLPGLRDLVLSGCSWI 1093
            + + H   +T     G +  + ++L      T++S K +S     L GLR L LS C  I
Sbjct: 185  VGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHIS---RGLTGLRLLNLSFCGGI 241

Query: 1094 AVSALCS-SSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLA 1152
            + + L   S    LR+L+++  + + D  +  L                    +  LRL+
Sbjct: 242  SDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLA-------------------MGSLRLS 282

Query: 1153 GLDIT------DASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINL 1206
            GLD++      D SL  I + +  L  L L  C H++D  IN +          L  +N+
Sbjct: 283  GLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSC-HISDDGINRMVR----QMHGLRTLNI 337

Query: 1207 SDCNKVTDQCLSFF-KRCGNICHIDLRYCKQVTKEGCEQ 1244
              C ++TD+ L    +    +  IDL  C ++TK G E+
Sbjct: 338  GQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLER 376


>gi|195927037 DNA (cytosine-5-)-methyltransferase 1 isoform a [Homo
           sapiens]
          Length = 1632

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 25/43 (58%), Positives = 30/43 (69%)

Query: 578 RRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQC 620
           +R RC  CE C + ECG+C  CKDM KFGG GR KQ+C  R+C
Sbjct: 665 KRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQACQERRC 707



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 58/248 (23%), Positives = 94/248 (37%), Gaps = 62/248 (25%)

Query: 732 PAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRLK--- 788
           PAKR+ + EE+ R +SDE  K+                  K + EK + ++ R+R+    
Sbjct: 191 PAKRKPQ-EESERAKSDESIKE----------------EDKDQDEKRRRVTSRERVARPL 233

Query: 789 PGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTA 848
           P +E +  +   R+ K  E+R     K LR   +EP        PK +  +     +   
Sbjct: 234 PAEEPERAKSGTRTEKE-EERDEKEEKRLRSQTKEP-------TPKQKLKEEPDREARAG 285

Query: 849 GPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEP 908
             + E  +G E+ +K     K R   K+L+ +   E        E      N Q    + 
Sbjct: 286 VQADEDEDGDEKDEK-----KHRSQPKDLAAKRRPE--------EKEPEKVNPQISDEKD 332

Query: 909 ESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQ 968
           E E EE +R                 TP+E      P+ +   R  +       PPKCIQ
Sbjct: 333 EDEKEEKRR---------------KTTPKE------PTEKKMARAKTVMNSKTHPPKCIQ 371

Query: 969 MERHVIRP 976
             +++  P
Sbjct: 372 CGQYLDDP 379


>gi|4503351 DNA (cytosine-5-)-methyltransferase 1 isoform b [Homo
           sapiens]
          Length = 1616

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 25/43 (58%), Positives = 30/43 (69%)

Query: 578 RRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQC 620
           +R RC  CE C + ECG+C  CKDM KFGG GR KQ+C  R+C
Sbjct: 649 KRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQACQERRC 691



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 58/248 (23%), Positives = 94/248 (37%), Gaps = 62/248 (25%)

Query: 732 PAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRLK--- 788
           PAKR+ + EE+ R +SDE  K+                  K + EK + ++ R+R+    
Sbjct: 175 PAKRKPQ-EESERAKSDESIKE----------------EDKDQDEKRRRVTSRERVARPL 217

Query: 789 PGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTA 848
           P +E +  +   R+ K  E+R     K LR   +EP        PK +  +     +   
Sbjct: 218 PAEEPERAKSGTRTEKE-EERDEKEEKRLRSQTKEP-------TPKQKLKEEPDREARAG 269

Query: 849 GPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEP 908
             + E  +G E+ +K     K R   K+L+ +   E        E      N Q    + 
Sbjct: 270 VQADEDEDGDEKDEK-----KHRSQPKDLAAKRRPE--------EKEPEKVNPQISDEKD 316

Query: 909 ESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQ 968
           E E EE +R                 TP+E      P+ +   R  +       PPKCIQ
Sbjct: 317 EDEKEEKRR---------------KTTPKE------PTEKKMARAKTVMNSKTHPPKCIQ 355

Query: 969 MERHVIRP 976
             +++  P
Sbjct: 356 CGQYLDDP 363


>gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens]
          Length = 479

 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 84/384 (21%), Positives = 142/384 (36%), Gaps = 98/384 (25%)

Query: 950  PPRVISRPPPSVSPPKCIQMERHVIRPPPISP---PPDSLPLDDGAAH---VMHREVWMA 1003
            PP   + PPPS++ P    + R  +   P +P   P  +L     A         ++   
Sbjct: 49   PPPPPTLPPPSLAAP----LSRAALAGGPCTPAGGPASALAPGHPAERPPLATDEKILNG 104

Query: 1004 VFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRI--------------------------- 1036
            +F Y S  + CV  +VC+ W R     + W  +                           
Sbjct: 105  LFWYFSACEKCVLAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNLQGFA 164

Query: 1037 -------------DLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLR 1083
                         DL+ C+ I    LS   ++   ++ L  + I+   L  ++ ++ G+ 
Sbjct: 165  ARGFEGFCLVGVSDLDICEFIDNYALS---KKGVKAMSLKRSTITDAGLEVMLEQMQGVV 221

Query: 1084 DLVLSGCS-------WIAVSA----LCSSSC---------------PLLRTLDVQWV--- 1114
             L LSGC+       W ++SA    L  S C               P L  L +Q     
Sbjct: 222  RLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVT 281

Query: 1115 ----------EGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLD-ITDASLRL 1163
                      +G     +R LLS       G ++    L N+  L L+G   +TD  + L
Sbjct: 282  DTALAYFTARQGHSTHTLR-LLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVEL 340

Query: 1164 IIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRC 1223
            +  ++  L  L LS+C  +TD ++  +          L E+ L  C ++TD  LS+    
Sbjct: 341  VAENLRKLRSLDLSWCPRITDMALEYVAC----DLHRLEELVLDRCVRITDTGLSYLSTM 396

Query: 1224 GNICHIDLRYCKQVTKEGCEQFIA 1247
             ++  + LR+C QV   G +  +A
Sbjct: 397  SSLRSLYLRWCCQVQDFGLKHLLA 420


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 80/306 (26%), Positives = 114/306 (37%), Gaps = 79/306 (25%)

Query: 717 LKEQKMNRD--NKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRK 774
           +K+Q  ++D  +KE +E ++ + E   +PRRR    S+   P    RR+S  V   +KR 
Sbjct: 144 MKKQDEDKDKRDKEEKESSREKRERSRSPRRRK---SRSPSP----RRRSSPVRRERKRS 196

Query: 775 YEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPK 834
           + +                   R K RS   A +            K+E   ELPE   K
Sbjct: 197 HSRSPR---------------HRTKSRSPSPAPE------------KKEKTPELPEPSVK 229

Query: 835 TRESDHSRSSS-------PTAGPSTEGAE-GPE-----EKKKVKMRRKRRLPNKELSREL 881
            +E     ++S       P   P  E  E  PE     EK+K K R + R  +K  SR  
Sbjct: 230 VKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTR 289

Query: 882 SKELNHEIQRTENSLANENQQPIKSEPESEGEEPKR--PPGICERPHRFSKGLNGTPREL 939
           S+  +H   R  +   + +  P +         P+R  PP     P R  +  +   R  
Sbjct: 290 SRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRR 349

Query: 940 RHQLGPS---------------------LRSPPRVISRPPPSVSPPKCIQMERHVIRP-P 977
           R     S                       SPPR   R  PS SPP+     RH  RP P
Sbjct: 350 RSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPR----RRH--RPSP 403

Query: 978 PISPPP 983
           P +PPP
Sbjct: 404 PATPPP 409



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 57/271 (21%), Positives = 98/271 (36%), Gaps = 33/271 (12%)

Query: 718 KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEK 777
           +E++ +R+ +E     +RR     +PRRRS    ++       R++S     R + K   
Sbjct: 157 EEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRE-------RKRSHSRSPRHRTKSRS 209

Query: 778 PQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPE------- 830
           P     +K   P   +   + K  S + A     +   P      EP++  PE       
Sbjct: 210 PSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEK 269

Query: 831 ----APPKTRESDHSRSSSPTAGPS----------TEGAEGPEEKKKVKMR---RKRRLP 873
                 P++R    SRS + +  PS             +  P  +   + R   R+R  P
Sbjct: 270 EKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPP 329

Query: 874 NKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGL- 932
            +       +     ++R   S A+ +     S        PK+PP     P R ++ L 
Sbjct: 330 RRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLS 389

Query: 933 -NGTPRELRHQLGPSLRSPPRVISRPPPSVS 962
            + +P   RH+  P    PP+    P P  S
Sbjct: 390 PSASPPRRRHRPSPPATPPPKTRHSPTPQQS 420



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 65/291 (22%), Positives = 100/291 (34%), Gaps = 54/291 (18%)

Query: 726 NKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRK 785
           + E + P +   +  E  RRR    S+   P    R+K      R++R    P     R+
Sbjct: 501 SSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPT---RR 557

Query: 786 RLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPE-------APPKTRES 838
           R  P         +RR       R    + P RR    P    P        +PP  R  
Sbjct: 558 RRSPSPAPP---PRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKR-- 612

Query: 839 DHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLAN 898
              R++SP   P    +  P  K++V        P K+ S  ++K  +  +    +S   
Sbjct: 613 ---RTASPPPPPKRRASPSPPPKRRVS----HSPPPKQRSSPVTKRRSPSL----SSKHR 661

Query: 899 ENQQPIKSEPESEGEEPK---------RPPGICERPHRFSKGLNGTPRELRHQLGPSLRS 949
           +   P +S  E+   +P          R P     P    +G + +P+  R    PS R 
Sbjct: 662 KGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQR-RQSPSPSTR- 719

Query: 950 PPRVISRPP----------PSVSPPKCIQMERHV-------IRPPPISPPP 983
           P R +SR P          PS    + +   R V        + PP  P P
Sbjct: 720 PIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSP 770



 Score = 37.4 bits (85), Expect = 0.092
 Identities = 57/249 (22%), Positives = 92/249 (36%), Gaps = 45/249 (18%)

Query: 699 KQKRGPGFKYAS-NLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPD 757
           KQ+  P  K  S +L     K    +R  +E + P   +     +PR R+ + S   PP 
Sbjct: 642 KQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRH-SPSPRPRAPQTSSSPPP- 699

Query: 758 GLLRRKSDDVHLRKKRKYEKPQELSGRKRL-KPGKEDKLFRKKRRSWKNAEDRMALANKP 816
             +RR +     R++      + +    R  +P K  K      +S +      +++  P
Sbjct: 700 --VRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSP 757

Query: 817 LRRFKQEPEDELPEAPPKTRESDH-----------SRSSSPTAGPST------EGAEGPE 859
                 EP  + P APP   +S              ++ SPT  PS       EG    +
Sbjct: 758 ------EPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKK 811

Query: 860 EKKKVKMRRKRRLPNKELSRELSKEL---------NHEIQRTENSLANENQQPI-----K 905
           +KKK K  +K +   K    +  K +            I     +LA E  +P+     K
Sbjct: 812 KKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQE--EPVAAPEPK 869

Query: 906 SEPESEGEE 914
            E ESE E+
Sbjct: 870 KETESEAED 878



 Score = 34.7 bits (78), Expect = 0.59
 Identities = 35/136 (25%), Positives = 58/136 (42%), Gaps = 23/136 (16%)

Query: 377 LEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPALR 436
           ++ ++E  D++ +EE+E   E   R R+P+     S SP            ++  +P  R
Sbjct: 144 MKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSP------------RRRSSPVRR 191

Query: 437 FLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESL 496
             KR+ S       KS        ++P  SPA E   K   L E  +K  +  V++  S 
Sbjct: 192 ERKRSHSRSPRHRTKS--------RSP--SPAPEKKEKTPELPEPSVKVKEPSVQEATST 241

Query: 497 PENKKC-VPEGIEDPQ 511
            +  K   PE I +P+
Sbjct: 242 SDILKVPKPEPIPEPK 257


>gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2 [Homo
            sapiens]
          Length = 690

 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 63/251 (25%), Positives = 102/251 (40%), Gaps = 39/251 (15%)

Query: 1002 MAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLD 1061
            + +F YLS +D+ +C +V   W        LW  ID +  K++ P        +  VS  
Sbjct: 164  LQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIP-------DKYIVSTL 216

Query: 1062 LSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQ 1121
              W             RL  LR L   GC     +    S C  L+ L+V       D  
Sbjct: 217  QRW-------------RLNVLR-LNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDES 262

Query: 1122 MRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNH 1181
            MR +    ++  PG          ++ L L+   IT+ ++RL+ RH   L  L L+YC  
Sbjct: 263  MRHI----SEGCPG----------VLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRR 308

Query: 1182 VTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFF-KRCGNICHIDLRYCKQVTKE 1240
             TD+ +  L  +G      L  ++LS C +++ Q   +    C  I H+ +     +T +
Sbjct: 309  FTDKGLQYLN-LGNGCH-KLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLT-D 365

Query: 1241 GCEQFIAEMSS 1251
             C + + E  S
Sbjct: 366  NCVKALVEKCS 376



 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 51/218 (23%), Positives = 96/218 (44%), Gaps = 38/218 (17%)

Query: 1085 LVLSGCSWIAVSAL--CSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPT-------DNRPG 1135
            L LSGC+ I+V      ++SC  +  L +  +  L D  ++ L+   +          P 
Sbjct: 329  LDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPH 388

Query: 1136 QMDNRSKLRNIVELRLAGLD----ITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLT 1191
              D   +  +  +LR    +    +TDAS + I ++ P LS ++++ C  +TD S+  L+
Sbjct: 389  ISDCTFRALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS 448

Query: 1192 AVGTTTRDSLT-----------------------EINLSDCNKVTD-QCLSFFKRCGNIC 1227
             +   T  +L                        E+NLS+C +++D   +   +RC N+ 
Sbjct: 449  PLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLN 508

Query: 1228 HIDLRYCKQVTKEGCEQFIAEMSSFQGRSCSTTRLGDE 1265
            ++ LR C+ +T +G   +I  + S      S T + +E
Sbjct: 509  YLSLRNCEHLTAQGI-GYIVNIFSLVSIDLSGTDISNE 545



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 41/174 (23%), Positives = 84/174 (48%), Gaps = 22/174 (12%)

Query: 1082 LRDLVLSGCSWIAVSALC--SSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDN 1139
            +R+L LS C  ++ +++   S  CP L  L ++  E L            T    G + N
Sbjct: 481  IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHL------------TAQGIGYIVN 528

Query: 1140 RSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTA---VGTT 1196
               + ++V + L+G DI++  L ++ RH   L +L +S C  +TD  I +  +   + + 
Sbjct: 529  ---IFSLVSIDLSGTDISNEGLNVLSRHKK-LKELSVSECYRITDDGIQITDSAMEMLSA 584

Query: 1197 TRDSLTEINLSDCNKVTDQCLSFFK-RCGNICHIDLRYCKQVTKEGCEQFIAEM 1249
                L  +++S C  +TDQ L   +  C  +  + ++YC  ++K+  ++  +++
Sbjct: 585  KCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSSKV 638


>gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1 [Homo
            sapiens]
          Length = 735

 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 63/251 (25%), Positives = 102/251 (40%), Gaps = 39/251 (15%)

Query: 1002 MAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLD 1061
            + +F YLS +D+ +C +V   W        LW  ID +  K++ P        +  VS  
Sbjct: 164  LQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIP-------DKYIVSTL 216

Query: 1062 LSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQ 1121
              W             RL  LR L   GC     +    S C  L+ L+V       D  
Sbjct: 217  QRW-------------RLNVLR-LNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDES 262

Query: 1122 MRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNH 1181
            MR +    ++  PG          ++ L L+   IT+ ++RL+ RH   L  L L+YC  
Sbjct: 263  MRHI----SEGCPG----------VLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRR 308

Query: 1182 VTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFF-KRCGNICHIDLRYCKQVTKE 1240
             TD+ +  L  +G      L  ++LS C +++ Q   +    C  I H+ +     +T +
Sbjct: 309  FTDKGLQYLN-LGNGCH-KLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLT-D 365

Query: 1241 GCEQFIAEMSS 1251
             C + + E  S
Sbjct: 366  NCVKALVEKCS 376



 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 51/218 (23%), Positives = 96/218 (44%), Gaps = 38/218 (17%)

Query: 1085 LVLSGCSWIAVSAL--CSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPT-------DNRPG 1135
            L LSGC+ I+V      ++SC  +  L +  +  L D  ++ L+   +          P 
Sbjct: 329  LDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPH 388

Query: 1136 QMDNRSKLRNIVELRLAGLD----ITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLT 1191
              D   +  +  +LR    +    +TDAS + I ++ P LS ++++ C  +TD S+  L+
Sbjct: 389  ISDCTFRALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS 448

Query: 1192 AVGTTTRDSLT-----------------------EINLSDCNKVTD-QCLSFFKRCGNIC 1227
             +   T  +L                        E+NLS+C +++D   +   +RC N+ 
Sbjct: 449  PLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLN 508

Query: 1228 HIDLRYCKQVTKEGCEQFIAEMSSFQGRSCSTTRLGDE 1265
            ++ LR C+ +T +G   +I  + S      S T + +E
Sbjct: 509  YLSLRNCEHLTAQGI-GYIVNIFSLVSIDLSGTDISNE 545



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 41/183 (22%), Positives = 83/183 (45%), Gaps = 24/183 (13%)

Query: 1082 LRDLVLSGCSWIAVSALC--SSSCPLLRTLDVQWVEGLKDAQMRDLLS---------PPT 1130
            +R+L LS C  ++ +++   S  CP L  L ++  E L    +  +++           T
Sbjct: 481  IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGT 540

Query: 1131 DNRPGQMDNRSKLRNIVELRLAGL-DITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINL 1189
            D     ++  S+ + + EL ++    ITD  ++   +   +L  L +SYC+ ++D  I  
Sbjct: 541  DISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKA 600

Query: 1190 LTAVGTTTRDSLTEINLSDCNKVTDQCLSFFK-RCGNICHIDLRYCKQVTKE-------G 1241
            L         +LT ++++ C K+TD  +     +C  +  +D+  C  +T +       G
Sbjct: 601  LAIYCI----NLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIG 656

Query: 1242 CEQ 1244
            C+Q
Sbjct: 657  CKQ 659


>gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo
            sapiens]
          Length = 424

 Score = 57.4 bits (137), Expect = 9e-08
 Identities = 67/276 (24%), Positives = 117/276 (42%), Gaps = 51/276 (18%)

Query: 999  EVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITP-----LMLSGII 1053
            E+ + +FS L   +L     VC+ W R   D+ LW  +DL   K++ P     L+  G+I
Sbjct: 103  ELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTG-KNLHPDVTGRLLSQGVI 161

Query: 1054 --------RRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPL 1105
                      QP++   S   +    LS  +  +  L  ++              S C  
Sbjct: 162  AFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLHGIL--------------SQCSK 207

Query: 1106 LRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLD-ITDASLRLI 1164
            L+ L    +EGL+       LS P  N        +K  N+V L L+G    ++ +L+ +
Sbjct: 208  LQNLS---LEGLR-------LSDPIVN------TLAKNSNLVRLNLSGCSGFSEFALQTL 251

Query: 1165 IRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNK--VTDQCLSFFKR 1222
            +     L +L+LS+C   T++ + +  A      +++T++NLS   K        +  +R
Sbjct: 252  LSSCSRLDELNLSWCFDFTEKHVQVAVA---HVSETITQLNLSGYRKNLQKSDLSTLVRR 308

Query: 1223 CGNICHIDLRYCKQVTKEGCEQFIAEMSSFQGRSCS 1258
            C N+ H+DL     + K  C Q   +++  Q  S S
Sbjct: 309  CPNLVHLDLS-DSVMLKNDCFQEFFQLNYLQHLSLS 343


>gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo
            sapiens]
          Length = 410

 Score = 57.4 bits (137), Expect = 9e-08
 Identities = 67/276 (24%), Positives = 117/276 (42%), Gaps = 51/276 (18%)

Query: 999  EVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITP-----LMLSGII 1053
            E+ + +FS L   +L     VC+ W R   D+ LW  +DL   K++ P     L+  G+I
Sbjct: 103  ELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTG-KNLHPDVTGRLLSQGVI 161

Query: 1054 --------RRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPL 1105
                      QP++   S   +    LS  +  +  L  ++              S C  
Sbjct: 162  AFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLHGIL--------------SQCSK 207

Query: 1106 LRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLD-ITDASLRLI 1164
            L+ L    +EGL+       LS P  N        +K  N+V L L+G    ++ +L+ +
Sbjct: 208  LQNLS---LEGLR-------LSDPIVN------TLAKNSNLVRLNLSGCSGFSEFALQTL 251

Query: 1165 IRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNK--VTDQCLSFFKR 1222
            +     L +L+LS+C   T++ + +  A      +++T++NLS   K        +  +R
Sbjct: 252  LSSCSRLDELNLSWCFDFTEKHVQVAVA---HVSETITQLNLSGYRKNLQKSDLSTLVRR 308

Query: 1223 CGNICHIDLRYCKQVTKEGCEQFIAEMSSFQGRSCS 1258
            C N+ H+DL     + K  C Q   +++  Q  S S
Sbjct: 309  CPNLVHLDLS-DSVMLKNDCFQEFFQLNYLQHLSLS 343


>gi|21464115 methyl-CpG binding domain protein 1 isoform 2 [Homo
           sapiens]
          Length = 586

 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 23/47 (48%), Positives = 29/47 (61%), Gaps = 1/47 (2%)

Query: 576 RRRRTRCRKCEACLRT-ECGECHFCKDMKKFGGPGRMKQSCIMRQCI 621
           RR+  +C  C ACLR  +CG C FC D  KFGG  + +Q C  RQC+
Sbjct: 309 RRQNRKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCL 355


>gi|21464119 methyl-CpG binding domain protein 1 isoform PCM1 [Homo
           sapiens]
          Length = 556

 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 23/47 (48%), Positives = 29/47 (61%), Gaps = 1/47 (2%)

Query: 576 RRRRTRCRKCEACLRT-ECGECHFCKDMKKFGGPGRMKQSCIMRQCI 621
           RR+  +C  C ACLR  +CG C FC D  KFGG  + +Q C  RQC+
Sbjct: 283 RRQNRKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCL 329


>gi|21464117 methyl-CpG binding domain protein 1 isoform 1 [Homo
           sapiens]
          Length = 605

 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 23/47 (48%), Positives = 29/47 (61%), Gaps = 1/47 (2%)

Query: 576 RRRRTRCRKCEACLRT-ECGECHFCKDMKKFGGPGRMKQSCIMRQCI 621
           RR+  +C  C ACLR  +CG C FC D  KFGG  + +Q C  RQC+
Sbjct: 332 RRQNRKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCL 378


>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
            sapiens]
          Length = 2715

 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 23/48 (47%), Positives = 27/48 (56%), Gaps = 1/48 (2%)

Query: 574  GARRRRTRCRKCEACLRTE-CGECHFCKDMKKFGGPGRMKQSCIMRQC 620
            G + R  RC  C  CLR + CG C  C D  KFGGP   KQ C+ R+C
Sbjct: 958  GKKMRMARCGHCRGCLRVQDCGSCVNCLDKPKFGGPNTKKQCCVYRKC 1005



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 27/115 (23%), Positives = 43/115 (37%), Gaps = 8/115 (6%)

Query: 867 RRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPH 926
           +++++L ++E  ++  +E + E +  E     E   P   + E++   P   P     P 
Sbjct: 356 KQEQKLDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPPLTPPAPSPPP 415

Query: 927 RFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISP 981
                    P        P L  PP     PPP  SPP     E     PPP+ P
Sbjct: 416 PLPPPSTSPP--------PPLCPPPPPPVSPPPLPSPPPPPAQEEQEESPPPVVP 462



 Score = 34.3 bits (77), Expect = 0.77
 Identities = 76/362 (20%), Positives = 115/362 (31%), Gaps = 82/362 (22%)

Query: 692 NHAGKTGKQK-RGPGFKYASNLPGSLLKEQKMNRDN---KEGQEPAKRRSECEEAPRRRS 747
           +  G+ G+ + RG G  +      S  K+ KM + +   + GQ   +     ++ P+RR 
Sbjct: 286 SRGGRGGRGRGRGGGLPFVIKFV-SRAKKVKMGQLSLGLESGQGQGQHEESWQDVPQRRV 344

Query: 748 DEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAE 807
                  P      +K DD    KK + EK +E  G +     KE++   ++       E
Sbjct: 345 GSGQGGSPCWKKQEQKLDDEEEEKKEEEEKDKE--GEE-----KEERAVAEEMMPAAEKE 397

Query: 808 DRMALANKPLRRFKQEPEDELPEA----------PPKTRESDHSRSSSPTAGPSTEGAEG 857
           +   L   PL      P   LP            PP    S     S P      E  E 
Sbjct: 398 EAK-LPPPPLTPPAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQEEQEES 456

Query: 858 PEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKR 917
           P         RKR  P    S+   +E          +       P  +   + G  P+ 
Sbjct: 457 PPPVVPATCSRKRGRPPLTPSQRAERE-------AARAGPEGTSPPTPTPSTATGGPPED 509

Query: 918 PPGICERPHRFSKGLNG---------------TPREL---------RHQLGPSLRSP--- 950
            P +  +   F K +                 TPR           + ++ P LR P   
Sbjct: 510 SPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEVSPVLRPPITT 569

Query: 951 -PRVISRPPPSVSPPKC----------IQMERHVIR--------------PPPISPPPDS 985
            P V   P P  SPP+            +  R ++R              PPP +PPP  
Sbjct: 570 SPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPP 629

Query: 986 LP 987
            P
Sbjct: 630 AP 631



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 18/70 (25%), Positives = 29/70 (41%), Gaps = 12/70 (17%)

Query: 630  VCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECP 689
            VCL+C   G  +            L+ C +C +  HP CL+  E     + +   C  C 
Sbjct: 1203 VCLLCASKGLHE------------LVFCQVCCDPFHPFCLEEAERPLPQHHDTWCCRRCK 1250

Query: 690  KCNHAGKTGK 699
             C+  G+ G+
Sbjct: 1251 FCHVCGRKGR 1260



 Score = 32.0 bits (71), Expect = 3.8
 Identities = 35/150 (23%), Positives = 49/150 (32%), Gaps = 8/150 (5%)

Query: 815 KPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPN 874
           K  RRF     DE P  PPK   S   R    T+ P  +         +        +P 
Sbjct: 541 KTPRRFM----DEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPL 596

Query: 875 KELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNG 934
            E  R + +E          SL  E   P  + P      P   P    R     +    
Sbjct: 597 PEKRRSILREPTFRW----TSLTRELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQF 652

Query: 935 TPRELRHQLGPSLRSPPRVISRPPPSVSPP 964
           TP E   ++  S+ +PP + +   P   PP
Sbjct: 653 TPSEAHLKIYESVLTPPPLGAPEAPEPEPP 682


>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 275

 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 39/177 (22%), Positives = 77/177 (43%), Gaps = 18/177 (10%)

Query: 718 KEQKMNRDNKE---------GQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVH 768
           KE+K  R  KE         G+E  ++R E E+  + R ++  +K   +   R +     
Sbjct: 52  KERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGR 111

Query: 769 LRKKRKYEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDEL 828
             +K+K E+ +     K+ +  K  K  +KKRR  +  E       +  ++ K+E  ++ 
Sbjct: 112 RERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKK 171

Query: 829 PEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKEL 885
            E   K R+ +  R          E  E  +E+KK + ++K R  +++  R+   ++
Sbjct: 172 RERNRKERKKERERK---------ERRERKKERKKERRKKKERKKDRKTDRQTDSQV 219



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 51/199 (25%), Positives = 81/199 (40%), Gaps = 24/199 (12%)

Query: 720 QKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQ 779
           Q+ +   KE +E  KR+ E E+  +R   +  KK                RKKR+  K +
Sbjct: 31  QRESERKKERREREKRKREREKERKRERGKKEKKK---------------RKKRERGKER 75

Query: 780 ELSGRKRLKPGKEDK-LFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRES 838
           E   ++R K  KE +   R+KR+  K   +R     +  ++ K+  E E      + R+ 
Sbjct: 76  ERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKR 135

Query: 839 DHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELS-KELNHEIQRTENSLA 897
              R          E   G  E+K    R+KR+   +E  RE + KE   E +R E    
Sbjct: 136 KKRRKKKRRKERKREKERGKRERK----RKKRKKEEREKKRERNRKERKKERERKER--- 188

Query: 898 NENQQPIKSEPESEGEEPK 916
            E ++  K E   + E  K
Sbjct: 189 RERKKERKKERRKKKERKK 207



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 48/212 (22%), Positives = 88/212 (41%), Gaps = 17/212 (8%)

Query: 718 KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEK 777
           +E +  ++ +E +E  KR  E E    R   E  K+   +    R+       K+RK  +
Sbjct: 32  RESERKKERRE-REKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERR 90

Query: 778 PQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRE 837
            +E   RK+ K  +E K  ++ RR  K  ++R     +  R  KQ  E +  +   K R 
Sbjct: 91  EKERRKRKKEKKKRERK--QRGRRERKKKKER----KERERENKQRRERKRKKRRKKKRR 144

Query: 838 SDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLA 897
            +  R          E   G  E+K+ K +++ R   +E +R+  K+     +R E    
Sbjct: 145 KERKR----------EKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKE 194

Query: 898 NENQQPIKSEPESEGEEPKRPPGICERPHRFS 929
            + ++  K E + + +  ++      RP R S
Sbjct: 195 RKKERRKKKERKKDRKTDRQTDSQVFRPLRES 226



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 31/117 (26%), Positives = 55/117 (47%), Gaps = 6/117 (5%)

Query: 696 KTGKQKRGPGFKYASNLPGSLLKEQK-MNRDNKEGQEPA--KRRSECEEAPRRRSDEHSK 752
           K  K+K+    K          KE+K   R+NK+ +E    KRR +     R+R  E  K
Sbjct: 96  KRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGK 155

Query: 753 KVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDR 809
           +       R+K +    R++ + E+ +E   ++R +  KE K  R+K++  +  +DR
Sbjct: 156 R-ERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKK--ERKKDR 209


>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
          Length = 843

 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 59/249 (23%), Positives = 103/249 (41%), Gaps = 21/249 (8%)

Query: 718 KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEK 777
           ++++  R+ +  +E  + R    E  R R  E  ++   D    R+ D+    ++RK E+
Sbjct: 389 RDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLER 448

Query: 778 P---QELSGRKRLKPG--KEDKLFRKKRRSWKNAEDR---MALANKPLRRFKQEPEDELP 829
               +E + ++RLK    +E K  R+  +  +  E+R   MA   K L+ F ++ +D+  
Sbjct: 449 KLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRD 508

Query: 830 EAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEI 889
           +  PK       +          E  E   +++K ++   R+     L  E   + + E+
Sbjct: 509 D--PKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQ----RLLAEGHPDPDAEL 562

Query: 890 QRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRS 949
           QR E       Q  IK EPESE EE        E+  +  K       E   +  P L+ 
Sbjct: 563 QRMEQEAERRRQPQIKQEPESEEEEE-------EKQEKEEKREEPMEEEEEPEQKPCLKP 615

Query: 950 PPRVISRPP 958
             R IS  P
Sbjct: 616 TLRPISSAP 624



 Score = 38.1 bits (87), Expect = 0.054
 Identities = 52/227 (22%), Positives = 95/227 (41%), Gaps = 23/227 (10%)

Query: 707 KYASNLPGSLLKEQKMNRDNKEGQEPAKRRSEC-EEAPRRRSDEHSKKVPPDGLLRRKSD 765
           K ASN  G+   E   N D +   E  KRR +  + A      E+S ++        +  
Sbjct: 176 KKASN--GNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPS----QES 229

Query: 766 DVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRKKR-RSWKNAEDRMALANKPLRRF---- 820
           D H RKK+K EK +++  R  + P     L  K+   + +  ED+  L ++ + +F    
Sbjct: 230 DSHPRKKKK-EKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTH 288

Query: 821 --------KQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRL 872
                   K+E E +  E   + RE +  R             E   EK+K + R + R 
Sbjct: 289 KKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERD 348

Query: 873 PNKELSRELSKELNHEIQRTEN--SLANENQQPIKSEPESEGEEPKR 917
            +++ ++E  ++ + E  R  +    ++ N+   +S  +S   E +R
Sbjct: 349 RDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERER 395


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 49/208 (23%), Positives = 97/208 (46%), Gaps = 13/208 (6%)

Query: 718 KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEK 777
           +++++ R  +E QE  +RR+E E+    +  E +++ P +  LRR+ + + LR+K + EK
Sbjct: 169 RDEELWRQRQEWQEREERRAEEEQLQSCKGHE-TEEFPDEEQLRRR-ELLELRRKGREEK 226

Query: 778 PQELSGRK-RLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDEL-----PEA 831
            Q+   R+ R+   +E+K +RK+    +  E+++       +R  QE E++L      E 
Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286

Query: 832 PPKTRESDHS-----RSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELN 886
             + +E +       R          E  E  EE+++ + RR+++   +E      +E  
Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEER 346

Query: 887 HEIQRTENSLANENQQPIKSEPESEGEE 914
            E Q          +Q ++ E E E  E
Sbjct: 347 REQQLRREQEEERREQQLRREQEEERRE 374



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 52/246 (21%), Positives = 101/246 (41%), Gaps = 38/246 (15%)

Query: 718  KEQKMNRDNKE--GQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKY 775
            +E+++ ++ ++   +EP KRR +  E  R+  +E   +   + LLR + +     ++R+Y
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQ--ELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199

Query: 776  EKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPL------------------ 817
             + +EL  +KR +  +++      +  W+  ++     NK                    
Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLR 1259

Query: 818  -RRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKE 876
             R+ +Q+ +  L E   + RE +  R          E     EE+K+ K R ++    K+
Sbjct: 1260 DRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQ 1319

Query: 877  LSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTP 936
            L RE         +R E     E  +  + E +   E  ++P    ER  +F +      
Sbjct: 1320 LLRE---------EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFRE------ 1364

Query: 937  RELRHQ 942
             ELRHQ
Sbjct: 1365 EELRHQ 1370



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 41/203 (20%), Positives = 91/203 (44%), Gaps = 15/203 (7%)

Query: 718  KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEK 777
            +++K   + ++ +   + R   +E  + R  E  +K   +  LR++++   LR++ +Y K
Sbjct: 1689 RDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRK 1748

Query: 778  PQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRE 837
              E    ++L+P +E++  R++ R      DR     + LR+ ++E +    E+  K RE
Sbjct: 1749 ILE---EEQLRPEREEQQLRRQER------DRKFREEEQLRQEREEQQLRSQESDRKFRE 1799

Query: 838  SDHSRS--SSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKE----LNHEIQR 891
             +  R         P     +   E++++++  + +   +E  R+   E       + +R
Sbjct: 1800 EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859

Query: 892  TENSLANENQQPIKSEPESEGEE 914
             E  L  E +Q  + E E +  E
Sbjct: 1860 EEQELWQEEEQKRRQERERKLRE 1882



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 47/219 (21%), Positives = 96/219 (43%), Gaps = 21/219 (9%)

Query: 718 KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSD---DVHLRKKRK 774
           +EQ++ R+ +E +   + R E EE  R +     +++  +  LRR+     +  LR++++
Sbjct: 347 REQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 406

Query: 775 YEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPK 834
             + Q+L   ++L+  +E +L R++       +       + L+R ++E  D L      
Sbjct: 407 LRREQQLRREQQLR--REQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEET 464

Query: 835 TRESDHSRSSSPTAGPSTEGAEG-----PEEKKKVKMRRKRRLPNKE-------LSRELS 882
            R     R          E  E       EE+++ + RR+++L  ++       L R+  
Sbjct: 465 ERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEE 524

Query: 883 KELNHEIQRTENSLANE----NQQPIKSEPESEGEEPKR 917
           +E   +  R+E  L  E     +Q +K E E   E+ +R
Sbjct: 525 EERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR 563



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 59/246 (23%), Positives = 102/246 (41%), Gaps = 48/246 (19%)

Query: 718  KEQKMNRDNKE--GQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRK-KRK 774
            K++K+ +  ++  G+EP KRR +  E   R  +E  ++   + LLR + +    ++ +R+
Sbjct: 962  KDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQE--EEQLLREEREKRRRQEWERQ 1019

Query: 775  YEKPQELSGRKR--LKPGKEDKLFRKKRRSWKN------------AEDRMALANKPLRR- 819
            Y K  EL   +   L+  +E +  +++ R ++              E+R     + L R 
Sbjct: 1020 YRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQ 1079

Query: 820  ------FKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLP 873
                   +QE E  L E P K R  +  R          E  +  EE+   + R KRR  
Sbjct: 1080 YRKEEELQQEEEQLLREEPEKRRRQERERQCR-----EEEELQQEEEQLLREEREKRR-- 1132

Query: 874  NKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLN 933
             +EL R+          R E  +  E +Q ++ EPE      KR     ER +R  + L 
Sbjct: 1133 RQELERQ---------YREEEEVQQEEEQLLREEPE------KRRRQELERQYREEEELQ 1177

Query: 934  GTPREL 939
                +L
Sbjct: 1178 QEEEQL 1183



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 53/228 (23%), Positives = 94/228 (41%), Gaps = 39/228 (17%)

Query: 712  LPGSLLKEQKMNRDNKEG---QEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVH 768
            L   L KEQ++ ++ +E    +E  KRR + +E  R+  +E   +   + LLR + +   
Sbjct: 895  LQEQLRKEQQLLQEEEEELQREEREKRRRQEQE--RQYREEEQLQQEEEQLLREEREKRR 952

Query: 769  LRKK-RKYEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDE 827
             +++ R+Y K ++L  ++    G+E +  R++ R  K  E+            +QE E  
Sbjct: 953  RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREE---------EELQQEEEQL 1003

Query: 828  LPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNH 887
            L E   K R  +  R          +  +  EE+   + R KRRL  +E      +EL  
Sbjct: 1004 LREEREKRRRQEWERQYR-----KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ 1058

Query: 888  EIQ-------------------RTENSLANENQQPIKSEPESEGEEPK 916
            E +                   R E  L  E +Q ++ EPE    + +
Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQER 1106



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 47/213 (22%), Positives = 93/213 (43%), Gaps = 16/213 (7%)

Query: 718 KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYE- 776
           ++Q+  R ++  QE  ++     E   R+ +E  ++  P      + ++  LRK  + E 
Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286

Query: 777 ---KPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPP 833
              + +E   ++RL+  +E +L RK+    +  ++      +   + ++  E +L     
Sbjct: 287 RRERQEEEQQQQRLR--REQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE 344

Query: 834 KTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRL-PNKELSRE----LSKELNHE 888
           + RE    R             E  EE+++ ++RR+++L   ++L RE      ++L  E
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE 404

Query: 889 IQ-RTENSLANENQ----QPIKSEPESEGEEPK 916
            Q R E  L  E Q    Q ++ E E E  E K
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQK 437



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 54/236 (22%), Positives = 95/236 (40%), Gaps = 20/236 (8%)

Query: 718 KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEK 777
           +E+++ +  K   E  +R  E  E  + ++ E  K   P    + +S+    R+ + Y +
Sbjct: 664 EEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESE-ADARQSKVYSR 722

Query: 778 PQELSGRKRLKPGKEDKLFRKKRRSWKNAE--DRMALANKPLRRF--------KQEPEDE 827
           P++  G++R +  +E +  R+    W+  E   R     +  R F        K E   +
Sbjct: 723 PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ 782

Query: 828 LPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNH 887
              A P  RE    R          E    PEE++K + RR+RR   KEL      E   
Sbjct: 783 RLSARPPLREQ-RERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQ---FLEEEE 838

Query: 888 EIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQL 943
           ++QR E +     QQ  + E   + ++ +R      R  ++   L    +  RH L
Sbjct: 839 QLQRRERA-----QQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL 889



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 39/187 (20%), Positives = 90/187 (48%), Gaps = 16/187 (8%)

Query: 716  LLKEQKMNRDNKEGQ--EPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKK- 772
            L +EQ++ R   E +  E  + R E E+   RR + + +K+  +  LR + ++  LR++ 
Sbjct: 1710 LQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERY-RKILEEEQLRPEREEQQLRRQE 1768

Query: 773  --RKYEKPQELSGRK---RLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPED- 826
              RK+ + ++L   +   +L+  + D+ FR++ +  +  E++     +   +++ E E  
Sbjct: 1769 RDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQL 1828

Query: 827  ELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPE------EKKKVKMRRKRRLPNKELSRE 880
            +L E   + R+    +  +     + E +   E      E++K +  R+R+L  + + R+
Sbjct: 1829 QLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQ 1888

Query: 881  LSKELNH 887
              +E  H
Sbjct: 1889 QKEEQRH 1895



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 51/219 (23%), Positives = 99/219 (45%), Gaps = 33/219 (15%)

Query: 716 LLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSD---DVHLRKK 772
           L +EQ++ R  +E     +RR + EE   ++     ++   +  LRR+ +   +  LR++
Sbjct: 300 LRREQQLRRKQEE-----ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRRE 354

Query: 773 RKYEKPQELSGRKRLKPGKEDKLFRKK--RRSWKNAEDRMALANKPLRRFKQ-EPEDELP 829
           ++ E+ ++   R++ +  +E +L R++  RR  +   ++     + LRR +Q   E +L 
Sbjct: 355 QEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 414

Query: 830 EAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKE------LSRELSK 883
                 RE    R          E  E   E+K  + RR++RL  ++      L RE   
Sbjct: 415 REQQLRREQQLRR----------EQEEERHEQKHEQERREQRLKREQEERRDWLKREEET 464

Query: 884 ELNHEIQRTENSLANENQQP-----IKSEPESEGEEPKR 917
           E  HE +R +  L  + ++      +K E E   E+ +R
Sbjct: 465 E-RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER 502



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 55/268 (20%), Positives = 109/268 (40%), Gaps = 14/268 (5%)

Query: 690  KCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDE 749
            +C    +  +Q R   F+          +++K   + ++ +   + R   EE  + R + 
Sbjct: 1400 RCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQER 1459

Query: 750  HSKKVPPDGLLR-RKSDDVHLRKK-RKY-EKPQELSGRKRLKPGKEDKLFRKKRRSWKNA 806
            H K    + LL+ R+   +H +++ RK+ E+ Q+L  ++R +  +E +L  ++       
Sbjct: 1460 HRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519

Query: 807  EDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKM 866
            E++     +  R+F QE +    +   + R  D  R          E  E  ++  + + 
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREE--QQLSRQER 1577

Query: 867  RRKRRLPNKELSRELSKELNHEIQRTENSL-ANENQQPIKSEPESEGEE-----PKRPPG 920
             RK RL  +++ R+   E   +    E  L   E QQ ++ E + +  E      +R   
Sbjct: 1578 DRKFRLEEQKVRRQ---EQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQ 1634

Query: 921  ICERPHRFSKGLNGTPRELRHQLGPSLR 948
               R  R  K L   P+  R +    LR
Sbjct: 1635 QLHRQERDRKFLEEEPQLRRQEREQQLR 1662



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 45/209 (21%), Positives = 88/209 (42%), Gaps = 29/209 (13%)

Query: 716 LLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKY 775
           L +EQ++ R+ +E +   K   E  E   +R  E  +    D L R +  + H +++RK 
Sbjct: 419 LRREQQLRREQEEERHEQKHEQERREQRLKREQEERR----DWLKREEETERHEQERRKQ 474

Query: 776 E--KPQELSGRKR-LKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPED----EL 828
           +  + QE   R+R LK  +E++  +++RR                ++ ++E E+     L
Sbjct: 475 QLKRDQEEERRERWLKLEEEERREQQERRE---------------QQLRREQEERREQRL 519

Query: 829 PEAPPKTRESDHSRSSSPTAGPSTEGAE---GPEEKKKVKMRRKRRLPNKELSRELSKEL 885
                + R     RS         E  E     EE+K+++  R+ +   +E      + L
Sbjct: 520 KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579

Query: 886 NHEIQRTENSLANENQQPIKSEPESEGEE 914
             E +R +  L  E ++ ++   + E  E
Sbjct: 580 KREEERRQQRLKREQEERLEQRLKREEVE 608



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 46/209 (22%), Positives = 88/209 (42%), Gaps = 23/209 (11%)

Query: 715 SLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRK 774
           SLL++++   D +   EP  R+ E E   RRR              R++ +      + +
Sbjct: 108 SLLQDRRQEEDQRRF-EPRDRQLEEEPGQRRRQK------------RQEQERELAEGEEQ 154

Query: 775 YEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPK 834
            EK + L  R R +  ++++L+R+ R+ W+  E+R A   + L+  K    +E P+    
Sbjct: 155 SEKQERLEQRDRQR--RDEELWRQ-RQEWQEREERRA-EEEQLQSCKGHETEEFPDEEQL 210

Query: 835 TRES-----DHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELS-RELSKELNHE 888
            R          R          +     EE++K   +R+  L  +E   +E   +   E
Sbjct: 211 RRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE 270

Query: 889 IQRTENSLANENQQPIKSEPESEGEEPKR 917
           +Q  E  L    +Q ++ E + E ++ +R
Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQR 299



 Score = 39.7 bits (91), Expect = 0.018
 Identities = 53/244 (21%), Positives = 102/244 (41%), Gaps = 51/244 (20%)

Query: 716 LLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPP---DGLLRRKSDDVHLRKK 772
           L  EQ++ R+ +E +E   +R E +   + R ++  K+      D LL+R+ +    R++
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE----RRQ 587

Query: 773 RKYEKPQELSGRKRLKPGKEDKLFRKKRRSWK---------------NAEDRMALANKPL 817
           ++ ++ QE    +RLK  + ++L +++RR  +                +E++     + L
Sbjct: 588 QRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQL 647

Query: 818 RR---------FKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRR 868
           RR          K+E E+E  E   K RE +  R     A          EE+++ + R 
Sbjct: 648 RREQQERREQRLKREEEEERLEQRLK-REHEEERREQELA---------EEEQEQARERI 697

Query: 869 KRRLPNKELSRELSKELNH-----EIQRTENSLANENQQPIKSEPESEGEEPKRPPGICE 923
           K R+P  +   E   +          ++ E     + Q+  +   ESE +  +      E
Sbjct: 698 KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE-----E 752

Query: 924 RPHR 927
           R HR
Sbjct: 753 RAHR 756



 Score = 39.3 bits (90), Expect = 0.024
 Identities = 51/246 (20%), Positives = 103/246 (41%), Gaps = 27/246 (10%)

Query: 686  WECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKE--GQEPAKRRSECEEAP 743
            WE  K N         +G   +    L  S L++++  +D +   G++  + R    E  
Sbjct: 1227 WEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDR----EQE 1282

Query: 744  RRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRKKRRSW 803
            RRR  +  +  P +  L R+      R+ RK ++ ++L   +R +  +  +  RK R   
Sbjct: 1283 RRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEE 1342

Query: 804  KNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKK 863
            +  ++R     +PLRR  QE + +  E   + +E               +G +  EE+++
Sbjct: 1343 QLLQER---EEQPLRR--QERDRKFREEELRHQE---------------QGRKFLEEEQR 1382

Query: 864  VKMRRKRRLPNKELSRELSKELNHEI-QRTENSLANENQQPIKSEPESEGEEPKRPPGIC 922
            ++ + + R   KE  +   +E   ++ Q  +     E QQ  + E + +  E ++     
Sbjct: 1383 LRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ 1442

Query: 923  ERPHRF 928
            ER  +F
Sbjct: 1443 ERERKF 1448



 Score = 37.4 bits (85), Expect = 0.092
 Identities = 44/212 (20%), Positives = 89/212 (41%), Gaps = 12/212 (5%)

Query: 718  KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLR--KKRKY 775
            ++ +  RD K  +E  +   E EE    R +   K +  +  LRR+  +  LR  + RK+
Sbjct: 1611 QQLRQERDRKF-REDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF 1669

Query: 776  EKPQEL---SGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAP 832
             + ++L      ++L+  + D+ FR++ +  +  E       +  +  +QE E +  E  
Sbjct: 1670 REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEE 1729

Query: 833  PKTRESDHS--RSSSPTAGPSTEGAEGP--EEKKKVKMRRKRRLPNKELSRELSKELNHE 888
               +E++    R          E    P  EE++  +  R R+   +E  R+  +E    
Sbjct: 1730 QLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLR 1789

Query: 889  IQRTENSLANENQQPIKSEPESEGEEPKRPPG 920
             Q ++     E Q  ++ E E +   P++  G
Sbjct: 1790 SQESDRKFREEEQ--LRQEREEQQLRPQQRDG 1819



 Score = 34.7 bits (78), Expect = 0.59
 Identities = 43/225 (19%), Positives = 90/225 (40%), Gaps = 18/225 (8%)

Query: 718  KEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEK 777
            +EQ +    ++     +R  +  E   R  ++  K +  +  LRR+  +   RK  K E+
Sbjct: 1341 EEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERE---RKFLKEEQ 1397

Query: 778  PQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRE 837
                  R++      D+ FR++ +     E       +  +  +QE E +  E   + R+
Sbjct: 1398 QLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQ 1457

Query: 838  SDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLA 897
              H +                EE++ ++ R +++L  +E  R+  +E   +++R E    
Sbjct: 1458 ERHRKFR--------------EEEQLLQEREEQQLHRQERDRKFLEE-EQQLRRQERDRK 1502

Query: 898  NENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQ 942
               Q+    EPE +  E ++     +R  +F +      R+ R Q
Sbjct: 1503 FREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQ 1547


>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform c [Homo sapiens]
          Length = 1462

 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 66/314 (21%), Positives = 114/314 (36%), Gaps = 40/314 (12%)

Query: 634  CGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKI----KESEGVVNDELPNCWECP 689
            CG+    D + E  G+     M+ S   E+I  G  ++    K  +G V +  P+     
Sbjct: 1161 CGKMRIGDEILEINGE-TTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPS----- 1214

Query: 690  KCNHAGKTGKQ-----KRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPR 744
               H   TG Q     + GP  +   +L  S   +   +  + E +  A+      E  R
Sbjct: 1215 SDRHGPATGPQGVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYSR 1274

Query: 745  RRSDEHS----KKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRKKR 800
            + ++ H+     + P  G  R K      R+  + E+    +G KR  P        K+R
Sbjct: 1275 QPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQAERAAAANGPKRRSP-------EKRR 1327

Query: 801  RSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSS-------SPTAGPSTE 853
               ++A++ +    K  +R    PE     +P + R+   SR              P   
Sbjct: 1328 EGTRSADNTLERREKHEKRRDVSPERRRERSPTRRRDGSPSRRRRSLERLLEQRRSPERR 1387

Query: 854  GAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGE 913
                PE + K   RR+ R P +   R L K       R     A+  ++   +  +  G 
Sbjct: 1388 RGGSPERRAKSTDRRRARSPERRRERSLDK-------RNREDRASHREREEANLKQDAGR 1440

Query: 914  EPKRPPGICERPHR 927
              + PP    RP++
Sbjct: 1441 SSRHPPEQRRRPYK 1454


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 53/239 (22%), Positives = 98/239 (41%), Gaps = 19/239 (7%)

Query: 691 CNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEH 750
           C+H  K   Q   PG++         ++ +K  +  +E +   +RR E E+  R R  E 
Sbjct: 22  CSHISKPCTQ---PGWQSEIREREREIETRKEGKKERESERKKERR-EREKRKREREKER 77

Query: 751 SKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRM 810
            ++       R K +    RKK + E+ +    R+R K  KE +   K+++  K    R 
Sbjct: 78  KRE-------RGKKEKKGERKKEERERKK----RRREKENKEGEEKEKRKKKEKKERGRT 126

Query: 811 ALANKPLRRFKQEPEDELPEAPPKT--RESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRR 868
           +   K   R ++   +E  E   K   RE +  R           G +  E K+K +  R
Sbjct: 127 SKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKER 186

Query: 869 KRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHR 927
           K+R  N++  ++  +      ++ E     E ++  + + ++   E +R  G  ER  R
Sbjct: 187 KKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKER--GKRERKER 243


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,112,553
Number of Sequences: 37866
Number of extensions: 3188106
Number of successful extensions: 23801
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 157
Number of HSP's successfully gapped in prelim test: 732
Number of HSP's that attempted gapping in prelim test: 18187
Number of HSP's gapped (non-prelim): 5145
length of query: 1265
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1151
effective length of database: 13,930,794
effective search space: 16034343894
effective search space used: 16034343894
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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