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Search of human proteins with 52630423
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
(380 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 779 0.0
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 779 0.0
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 541 e-154
gi|52630427 NCK adaptor protein 2 isoform B [Homo sapiens] 157 2e-38
gi|5729856 GRB2-related adaptor protein [Homo sapiens] 91 2e-18
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 89 9e-18
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 89 9e-18
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 89 9e-18
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 87 2e-17
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 87 2e-17
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 86 7e-17
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 86 7e-17
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 83 4e-16
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 83 4e-16
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 81 1e-15
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 81 2e-15
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 81 2e-15
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 81 2e-15
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 80 2e-15
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 78 1e-14
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 78 1e-14
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 77 2e-14
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 77 2e-14
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 77 2e-14
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 77 2e-14
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 77 2e-14
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 77 2e-14
gi|187475373 c-src tyrosine kinase [Homo sapiens] 77 3e-14
gi|4758078 c-src tyrosine kinase [Homo sapiens] 77 3e-14
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 76 4e-14
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 779 bits (2012), Expect = 0.0
Identities = 380/380 (100%), Positives = 380/380 (100%)
Query: 1 MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKN 60
MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKN
Sbjct: 1 MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKN 60
Query: 61 SLKKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKF 120
SLKKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKF
Sbjct: 61 SLKKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKF 120
Query: 121 AYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFL 180
AYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFL
Sbjct: 121 AYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFL 180
Query: 181 SLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNA 240
SLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNA
Sbjct: 181 SLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNA 240
Query: 241 RGQVGLVPKNYVVVLSDGPALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALN 300
RGQVGLVPKNYVVVLSDGPALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALN
Sbjct: 241 RGQVGLVPKNYVVVLSDGPALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALN 300
Query: 301 ERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCIGQRRFHTMDELVEHYK 360
ERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCIGQRRFHTMDELVEHYK
Sbjct: 301 ERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCIGQRRFHTMDELVEHYK 360
Query: 361 KAPIFTSEHGEKLYLVRALQ 380
KAPIFTSEHGEKLYLVRALQ
Sbjct: 361 KAPIFTSEHGEKLYLVRALQ 380
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 779 bits (2012), Expect = 0.0
Identities = 380/380 (100%), Positives = 380/380 (100%)
Query: 1 MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKN 60
MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKN
Sbjct: 1 MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKN 60
Query: 61 SLKKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKF 120
SLKKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKF
Sbjct: 61 SLKKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKF 120
Query: 121 AYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFL 180
AYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFL
Sbjct: 121 AYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFL 180
Query: 181 SLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNA 240
SLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNA
Sbjct: 181 SLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNA 240
Query: 241 RGQVGLVPKNYVVVLSDGPALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALN 300
RGQVGLVPKNYVVVLSDGPALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALN
Sbjct: 241 RGQVGLVPKNYVVVLSDGPALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALN 300
Query: 301 ERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCIGQRRFHTMDELVEHYK 360
ERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCIGQRRFHTMDELVEHYK
Sbjct: 301 ERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCIGQRRFHTMDELVEHYK 360
Query: 361 KAPIFTSEHGEKLYLVRALQ 380
KAPIFTSEHGEKLYLVRALQ
Sbjct: 361 KAPIFTSEHGEKLYLVRALQ 380
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 541 bits (1394), Expect = e-154
Identities = 264/382 (69%), Positives = 307/382 (80%), Gaps = 9/382 (2%)
Query: 1 MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKN 60
M EEV+V+AK+DY AQQ+QELDIKKNERLWLLDDSK+WWRVRN+ N+TG+VPSNYVERKN
Sbjct: 1 MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKN 60
Query: 61 SLKKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKF 120
S +K S+VKNLKDTLG+GK +RK S D S +P+ D+ +R+YDLN+PA+VKF
Sbjct: 61 SARKASIVKNLKDTLGIGKVKRKPSVPD-SASPADDSFVDPG----ERLYDLNMPAYVKF 115
Query: 121 AYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFL 180
Y+AEREDELSL+KG++V VMEKCSDGWWRGSYNGQ+GWFPSNYV EE D + L
Sbjct: 116 NYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSL 175
Query: 181 SLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNA 240
S + A ++N +VLHVVQ LYPFSS +EELNFEKG+ M+VIEKPENDPEWWKC+
Sbjct: 176 SEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKI 235
Query: 241 RGQVGLVPKNYVVVLSDGP---ALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAEC 297
G VGLVPKNYV V+ + P L P+ PQ Y PS +G+FAG WYYG VTRHQAE
Sbjct: 236 NGMVGLVPKNYVTVMQNNPLTSGLEPS-PPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEM 294
Query: 298 ALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCIGQRRFHTMDELVE 357
ALNERG EGDFLIRDSESSP+DFSVSLKA GKNKHFKVQL + VYCIGQR+F TM+ELVE
Sbjct: 295 ALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVE 354
Query: 358 HYKKAPIFTSEHGEKLYLVRAL 379
HYKKAPIFTSE GEKLYLV+ L
Sbjct: 355 HYKKAPIFTSEQGEKLYLVKHL 376
>gi|52630427 NCK adaptor protein 2 isoform B [Homo sapiens]
Length = 83
Score = 157 bits (396), Expect = 2e-38
Identities = 75/75 (100%), Positives = 75/75 (100%)
Query: 1 MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKN 60
MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKN
Sbjct: 1 MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKN 60
Query: 61 SLKKGSLVKNLKDTL 75
SLKKGSLVKNLKDTL
Sbjct: 61 SLKKGSLVKNLKDTL 75
Score = 37.7 bits (86), Expect = 0.017
Identities = 15/54 (27%), Positives = 32/54 (59%), Gaps = 3/54 (5%)
Query: 199 VVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYV 252
+V + +++ ++EL+ +K E + +++ + WW+ +NA + G VP NYV
Sbjct: 6 IVIAKWDYTAQQDQELDIKKNERLWLLDDSKT---WWRVRNAANRTGYVPSNYV 56
Score = 33.9 bits (76), Expect = 0.25
Identities = 17/48 (35%), Positives = 29/48 (60%), Gaps = 2/48 (4%)
Query: 119 KFAYVAEREDELSLVKGSRVTVMEKCSDGWWR-GSYNGQIGWFPSNYV 165
K+ Y A+++ EL + K R+ +++ S WWR + + G+ PSNYV
Sbjct: 10 KWDYTAQQDQELDIKKNERLWLLDD-SKTWWRVRNAANRTGYVPSNYV 56
>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
Length = 217
Score = 90.5 bits (223), Expect = 2e-18
Identities = 56/163 (34%), Positives = 86/163 (52%), Gaps = 29/163 (17%)
Query: 203 LYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALH 262
LY F + +EL F KG+T++++ E+D W+K + RG G +PKNY+ V H
Sbjct: 6 LYSFQATESDELAFNKGDTLKILNM-EDDQNWYKAE-LRGVEGFIPKNYIRVKP-----H 58
Query: 263 PAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSV 322
P WY G ++R AE L +R G FLIR+SESSP +FSV
Sbjct: 59 P---------------------WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSV 97
Query: 323 SLKASGKNKHFKV-QLVDNVYCIGQRRFHTMDELVEHYKKAPI 364
S+ + +HFKV + Y + + +F++++ELV+ Y+ I
Sbjct: 98 SVNYGDQVQHFKVLREASGKYFLWEEKFNSLNELVDFYRTTTI 140
Score = 52.8 bits (125), Expect = 5e-07
Identities = 55/251 (21%), Positives = 106/251 (42%), Gaps = 48/251 (19%)
Query: 8 IAKWDYTAQQDQELDIKKNERLWLL--DDSKTWWRVRNAANRTGYVPSNYVERK-NSLKK 64
+A + + A + EL K + L +L +D + W++ G++P NY+ K +
Sbjct: 4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAE-LRGVEGFIPKNYIRVKPHPWYS 62
Query: 65 GSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNI--PAFVKFAY 122
G + + L + + + R A + S+ E+ + + D++ + A K+
Sbjct: 63 GRISRQLAEEILM--KRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL 120
Query: 123 VAEREDELS-LVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLS 181
E+ + L+ LV R T + K + +E +SP
Sbjct: 121 WEEKFNSLNELVDFYRTTTIAK------------------KRQIFLRDEEPLLKSP---- 158
Query: 182 LRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNAR 241
GA + Q + FS+ +L+F +G+ +EV+E+P DP WW+ ++
Sbjct: 159 ---GACFAQAQ-----------FDFSAQDPSQLSFRRGDIIEVLERP--DPHWWRGRSC- 201
Query: 242 GQVGLVPKNYV 252
G+VG P++YV
Sbjct: 202 GRVGFFPRSYV 212
Score = 33.1 bits (74), Expect = 0.43
Identities = 15/50 (30%), Positives = 30/50 (60%), Gaps = 2/50 (4%)
Query: 9 AKWDYTAQQDQELDIKKNERLWLLD-DSKTWWRVRNAANRTGYVPSNYVE 57
A++D++AQ +L ++ + + +L+ WWR R+ R G+ P +YV+
Sbjct: 165 AQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRSCG-RVGFFPRSYVQ 213
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 88.6 bits (218), Expect = 9e-18
Identities = 65/255 (25%), Positives = 111/255 (43%), Gaps = 60/255 (23%)
Query: 8 IAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSL 67
IA + Y++ + +L + E + + WW + +R+G PSNYV+ K+ GS
Sbjct: 960 IALYPYSSVEPGDLTFTEGEEILVTQKDGEWW-TGSIGDRSGIFPSNYVKPKDQESFGSA 1018
Query: 68 VKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAERE 127
K+ G + +K A V AYVA
Sbjct: 1019 SKS-------GASNKKPEI-----------------------------AQVTSAYVASGS 1042
Query: 128 DELSLVKGSRVTVMEKCSDGWWRGSYNG-----QIGWFPSNYVLEEVDEAAAESPSFLSL 182
++LSL G + +++K + GWW+G Q GWFP+++V + +P+F +
Sbjct: 1043 EQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPV 1102
Query: 183 RKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARG 242
+ V +Y +++ E+EL+F KG+ + V+ K +DP+WW+ G
Sbjct: 1103 CQ---------------VIAMYDYAANNEDELSFSKGQLINVMNK--DDPDWWQ-GEING 1144
Query: 243 QVGLVPKNYVVVLSD 257
GL P NYV + +D
Sbjct: 1145 VTGLFPSNYVKMTTD 1159
Score = 68.9 bits (167), Expect = 7e-12
Identities = 51/165 (30%), Positives = 82/165 (49%), Gaps = 16/165 (9%)
Query: 92 TPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAEREDELSLVKGSRVTVMEKCSDGWWRG 151
T S + P +G G ++ + N+ A ++ A++++ L+ K +TV+E+ + WW G
Sbjct: 855 TVSPGSVSPIHGQG--QVVE-NLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFG 910
Query: 152 SYNGQIGWFPSNYV-LEEVDEAAAESPSFLSL---RKGASLSNGQGSRVLHVVQTLYPFS 207
+G GWFP +YV + E E P L +K S + G + LYP+S
Sbjct: 911 EVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYI----ALYPYS 966
Query: 208 SVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYV 252
SV +L F +GE + V +K D EWW + + G+ P NYV
Sbjct: 967 SVEPGDLTFTEGEEILVTQK---DGEWW-TGSIGDRSGIFPSNYV 1007
Score = 67.4 bits (163), Expect = 2e-11
Identities = 63/273 (23%), Positives = 115/273 (42%), Gaps = 51/273 (18%)
Query: 1 MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKN 60
+ E + A +TA++D L+ K++ + +L+ + WW R G+ P +YV+
Sbjct: 870 VVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGR-GWFPKSYVK--- 925
Query: 61 SLKKGSLVKNLK-DTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVK 119
+ GS VK + + L ++ TSA Y +
Sbjct: 926 -IIPGSEVKREEPEALYAAVNKKPTSAA----------------------YSVGEEYIAL 962
Query: 120 FAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSF 179
+ Y + +L+ +G + V +K + WW GS + G FPSNYV + E+
Sbjct: 963 YPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSIGDRSGIFPSNYVKPKDQESF------ 1015
Query: 180 LSLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCK- 238
G++ +G ++ + Q + + E+L+ G+ + +++K N WW+ +
Sbjct: 1016 -----GSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKK--NTSGWWQGEL 1068
Query: 239 NARG---QVGLVPKNYVVVLSDG-----PALHP 263
ARG Q G P ++V +L PA HP
Sbjct: 1069 QARGKKRQKGWFPASHVKLLGPSSERATPAFHP 1101
Score = 51.2 bits (121), Expect = 2e-06
Identities = 55/227 (24%), Positives = 80/227 (35%), Gaps = 67/227 (29%)
Query: 120 FAYVAEREDELSLVKGSRVTVMEKC--SDGWWRGSYNGQIGWFPSNYV--LEEVDEAAAE 175
+ + A DE+S G + V EK GW GS+ G GWFP NYV + + A
Sbjct: 739 YPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAV 798
Query: 176 SPSFLSLRKGASLS---------------------------------------------- 189
SP L SLS
Sbjct: 799 SPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSP 858
Query: 190 ------NGQGSRVLHV-VQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARG 242
+GQG V ++ Q L +++ + LNF K + + V+E+ EN WW G
Sbjct: 859 GSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN---WW-FGEVHG 914
Query: 243 QVGLVPKNYVVVLSDGPALHPAHAPQISYTG----PSSSGRFAGREW 285
G PK+YV ++ P+ Y P+S+ G E+
Sbjct: 915 GRGWFPKSYVKIIPGSEV--KREEPEALYAAVNKKPTSAAYSVGEEY 959
Score = 39.3 bits (90), Expect = 0.006
Identities = 66/295 (22%), Positives = 118/295 (40%), Gaps = 49/295 (16%)
Query: 16 QQDQELDIKKNERLWLLDDSKTW-WRVRNAANRTGYVPSNYVE--RKNSLKKGSLVKNLK 72
Q QEL +N+ ++L+ + + R++N + P + V K SL+K L + LK
Sbjct: 539 QLQQELQEYQNKLIYLVPEKQLLNERIKNM--QFSNTPDSGVSLLHKKSLEKEELCQRLK 596
Query: 73 DTLGL--GKTRRKTSARDASPTPSTDAE--YPANGSGADRIYDLNIPAFVKFAYVAERED 128
+ L +T K S D+ + Y +++Y + + D
Sbjct: 597 EQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKI-------------KRD 643
Query: 129 ELSLVKGSRVTVMEK--CSDGWWRGSYNGQIGWFPSNYVLEE------VDEAAAESPSFL 180
+L ++ R+ +M+K D R + G+ + N EE + E +
Sbjct: 644 KLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQE 703
Query: 181 SLRKG------------ASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKP 228
RK A + + VL + LYPF + +E++F G+ ++V EK
Sbjct: 704 EERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKT 763
Query: 229 ENDPEWWKCKNARGQVGLVPKNYVVVL---SDGPALHPAHA---PQISYTGPSSS 277
+P W + +G G P NYV + + A+ P A P +S + S+S
Sbjct: 764 VGEP-GWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTS 817
Score = 35.8 bits (81), Expect = 0.066
Identities = 19/52 (36%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 7 VIAKWDYTAQQDQELDIKKNERLWLLD-DSKTWWRVRNAANRTGYVPSNYVE 57
VIA +DY A + EL K + + +++ D WW+ TG PSNYV+
Sbjct: 1105 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQ-GEINGVTGLFPSNYVK 1155
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 88.6 bits (218), Expect = 9e-18
Identities = 65/255 (25%), Positives = 111/255 (43%), Gaps = 60/255 (23%)
Query: 8 IAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSL 67
IA + Y++ + +L + E + + WW + +R+G PSNYV+ K+ GS
Sbjct: 987 IALYPYSSVEPGDLTFTEGEEILVTQKDGEWW-TGSIGDRSGIFPSNYVKPKDQESFGSA 1045
Query: 68 VKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAERE 127
K+ G + +K A V AYVA
Sbjct: 1046 SKS-------GASNKKPEI-----------------------------AQVTSAYVASGS 1069
Query: 128 DELSLVKGSRVTVMEKCSDGWWRGSYNG-----QIGWFPSNYVLEEVDEAAAESPSFLSL 182
++LSL G + +++K + GWW+G Q GWFP+++V + +P+F +
Sbjct: 1070 EQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPV 1129
Query: 183 RKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARG 242
+ V +Y +++ E+EL+F KG+ + V+ K +DP+WW+ G
Sbjct: 1130 CQ---------------VIAMYDYAANNEDELSFSKGQLINVMNK--DDPDWWQ-GEING 1171
Query: 243 QVGLVPKNYVVVLSD 257
GL P NYV + +D
Sbjct: 1172 VTGLFPSNYVKMTTD 1186
Score = 68.9 bits (167), Expect = 7e-12
Identities = 51/165 (30%), Positives = 82/165 (49%), Gaps = 16/165 (9%)
Query: 92 TPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAEREDELSLVKGSRVTVMEKCSDGWWRG 151
T S + P +G G ++ + N+ A ++ A++++ L+ K +TV+E+ + WW G
Sbjct: 882 TVSPGSVSPIHGQG--QVVE-NLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFG 937
Query: 152 SYNGQIGWFPSNYV-LEEVDEAAAESPSFLSL---RKGASLSNGQGSRVLHVVQTLYPFS 207
+G GWFP +YV + E E P L +K S + G + LYP+S
Sbjct: 938 EVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYI----ALYPYS 993
Query: 208 SVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYV 252
SV +L F +GE + V +K D EWW + + G+ P NYV
Sbjct: 994 SVEPGDLTFTEGEEILVTQK---DGEWW-TGSIGDRSGIFPSNYV 1034
Score = 67.4 bits (163), Expect = 2e-11
Identities = 63/273 (23%), Positives = 115/273 (42%), Gaps = 51/273 (18%)
Query: 1 MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKN 60
+ E + A +TA++D L+ K++ + +L+ + WW R G+ P +YV+
Sbjct: 897 VVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGR-GWFPKSYVK--- 952
Query: 61 SLKKGSLVKNLK-DTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVK 119
+ GS VK + + L ++ TSA Y +
Sbjct: 953 -IIPGSEVKREEPEALYAAVNKKPTSAA----------------------YSVGEEYIAL 989
Query: 120 FAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSF 179
+ Y + +L+ +G + V +K + WW GS + G FPSNYV + E+
Sbjct: 990 YPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSIGDRSGIFPSNYVKPKDQESF------ 1042
Query: 180 LSLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCK- 238
G++ +G ++ + Q + + E+L+ G+ + +++K N WW+ +
Sbjct: 1043 -----GSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKK--NTSGWWQGEL 1095
Query: 239 NARG---QVGLVPKNYVVVLSDG-----PALHP 263
ARG Q G P ++V +L PA HP
Sbjct: 1096 QARGKKRQKGWFPASHVKLLGPSSERATPAFHP 1128
Score = 51.2 bits (121), Expect = 2e-06
Identities = 55/227 (24%), Positives = 80/227 (35%), Gaps = 67/227 (29%)
Query: 120 FAYVAEREDELSLVKGSRVTVMEKC--SDGWWRGSYNGQIGWFPSNYV--LEEVDEAAAE 175
+ + A DE+S G + V EK GW GS+ G GWFP NYV + + A
Sbjct: 766 YPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAV 825
Query: 176 SPSFLSLRKGASLS---------------------------------------------- 189
SP L SLS
Sbjct: 826 SPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSP 885
Query: 190 ------NGQGSRVLHV-VQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARG 242
+GQG V ++ Q L +++ + LNF K + + V+E+ EN WW G
Sbjct: 886 GSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN---WW-FGEVHG 941
Query: 243 QVGLVPKNYVVVLSDGPALHPAHAPQISYTG----PSSSGRFAGREW 285
G PK+YV ++ P+ Y P+S+ G E+
Sbjct: 942 GRGWFPKSYVKIIPGSEV--KREEPEALYAAVNKKPTSAAYSVGEEY 986
Score = 38.9 bits (89), Expect = 0.008
Identities = 27/88 (30%), Positives = 44/88 (50%), Gaps = 7/88 (7%)
Query: 196 VLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVL 255
VL + LYPF + +E++F G+ ++V EK +P W + +G G P NYV +
Sbjct: 758 VLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEP-GWLYGSFQGNFGWFPCNYVEKM 816
Query: 256 ---SDGPALHPAHA---PQISYTGPSSS 277
+ A+ P A P +S + S+S
Sbjct: 817 PSSENEKAVSPKKALLPPTVSLSATSTS 844
Score = 35.8 bits (81), Expect = 0.066
Identities = 19/52 (36%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 7 VIAKWDYTAQQDQELDIKKNERLWLLD-DSKTWWRVRNAANRTGYVPSNYVE 57
VIA +DY A + EL K + + +++ D WW+ TG PSNYV+
Sbjct: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQ-GEINGVTGLFPSNYVK 1182
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 88.6 bits (218), Expect = 9e-18
Identities = 65/255 (25%), Positives = 111/255 (43%), Gaps = 60/255 (23%)
Query: 8 IAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSL 67
IA + Y++ + +L + E + + WW + +R+G PSNYV+ K+ GS
Sbjct: 987 IALYPYSSVEPGDLTFTEGEEILVTQKDGEWW-TGSIGDRSGIFPSNYVKPKDQESFGSA 1045
Query: 68 VKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAERE 127
K+ G + +K A V AYVA
Sbjct: 1046 SKS-------GASNKKPEI-----------------------------AQVTSAYVASGS 1069
Query: 128 DELSLVKGSRVTVMEKCSDGWWRGSYNG-----QIGWFPSNYVLEEVDEAAAESPSFLSL 182
++LSL G + +++K + GWW+G Q GWFP+++V + +P+F +
Sbjct: 1070 EQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPV 1129
Query: 183 RKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARG 242
+ V +Y +++ E+EL+F KG+ + V+ K +DP+WW+ G
Sbjct: 1130 CQ---------------VIAMYDYAANNEDELSFSKGQLINVMNK--DDPDWWQ-GEING 1171
Query: 243 QVGLVPKNYVVVLSD 257
GL P NYV + +D
Sbjct: 1172 VTGLFPSNYVKMTTD 1186
Score = 68.9 bits (167), Expect = 7e-12
Identities = 51/165 (30%), Positives = 82/165 (49%), Gaps = 16/165 (9%)
Query: 92 TPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAEREDELSLVKGSRVTVMEKCSDGWWRG 151
T S + P +G G ++ + N+ A ++ A++++ L+ K +TV+E+ + WW G
Sbjct: 882 TVSPGSVSPIHGQG--QVVE-NLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFG 937
Query: 152 SYNGQIGWFPSNYV-LEEVDEAAAESPSFLSL---RKGASLSNGQGSRVLHVVQTLYPFS 207
+G GWFP +YV + E E P L +K S + G + LYP+S
Sbjct: 938 EVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYI----ALYPYS 993
Query: 208 SVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYV 252
SV +L F +GE + V +K D EWW + + G+ P NYV
Sbjct: 994 SVEPGDLTFTEGEEILVTQK---DGEWW-TGSIGDRSGIFPSNYV 1034
Score = 67.4 bits (163), Expect = 2e-11
Identities = 63/273 (23%), Positives = 115/273 (42%), Gaps = 51/273 (18%)
Query: 1 MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKN 60
+ E + A +TA++D L+ K++ + +L+ + WW R G+ P +YV+
Sbjct: 897 VVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGR-GWFPKSYVK--- 952
Query: 61 SLKKGSLVKNLK-DTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVK 119
+ GS VK + + L ++ TSA Y +
Sbjct: 953 -IIPGSEVKREEPEALYAAVNKKPTSAA----------------------YSVGEEYIAL 989
Query: 120 FAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSF 179
+ Y + +L+ +G + V +K + WW GS + G FPSNYV + E+
Sbjct: 990 YPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSIGDRSGIFPSNYVKPKDQESF------ 1042
Query: 180 LSLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCK- 238
G++ +G ++ + Q + + E+L+ G+ + +++K N WW+ +
Sbjct: 1043 -----GSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKK--NTSGWWQGEL 1095
Query: 239 NARG---QVGLVPKNYVVVLSDG-----PALHP 263
ARG Q G P ++V +L PA HP
Sbjct: 1096 QARGKKRQKGWFPASHVKLLGPSSERATPAFHP 1128
Score = 51.2 bits (121), Expect = 2e-06
Identities = 55/227 (24%), Positives = 80/227 (35%), Gaps = 67/227 (29%)
Query: 120 FAYVAEREDELSLVKGSRVTVMEKC--SDGWWRGSYNGQIGWFPSNYV--LEEVDEAAAE 175
+ + A DE+S G + V EK GW GS+ G GWFP NYV + + A
Sbjct: 766 YPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAV 825
Query: 176 SPSFLSLRKGASLS---------------------------------------------- 189
SP L SLS
Sbjct: 826 SPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSP 885
Query: 190 ------NGQGSRVLHV-VQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARG 242
+GQG V ++ Q L +++ + LNF K + + V+E+ EN WW G
Sbjct: 886 GSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN---WW-FGEVHG 941
Query: 243 QVGLVPKNYVVVLSDGPALHPAHAPQISYTG----PSSSGRFAGREW 285
G PK+YV ++ P+ Y P+S+ G E+
Sbjct: 942 GRGWFPKSYVKIIPGSEV--KREEPEALYAAVNKKPTSAAYSVGEEY 986
Score = 38.9 bits (89), Expect = 0.008
Identities = 27/88 (30%), Positives = 44/88 (50%), Gaps = 7/88 (7%)
Query: 196 VLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVL 255
VL + LYPF + +E++F G+ ++V EK +P W + +G G P NYV +
Sbjct: 758 VLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEP-GWLYGSFQGNFGWFPCNYVEKM 816
Query: 256 ---SDGPALHPAHA---PQISYTGPSSS 277
+ A+ P A P +S + S+S
Sbjct: 817 PSSENEKAVSPKKALLPPTVSLSATSTS 844
Score = 35.8 bits (81), Expect = 0.066
Identities = 19/52 (36%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 7 VIAKWDYTAQQDQELDIKKNERLWLLD-DSKTWWRVRNAANRTGYVPSNYVE 57
VIA +DY A + EL K + + +++ D WW+ TG PSNYV+
Sbjct: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQ-GEINGVTGLFPSNYVK 1182
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 87.4 bits (215), Expect = 2e-17
Identities = 69/255 (27%), Positives = 106/255 (41%), Gaps = 53/255 (20%)
Query: 8 IAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSL 67
IA + Y + + +L ++ + + + WW ++ G PSNYV
Sbjct: 1008 IAMYTYESSEQGDLTFQQGDVILVTKKDGDWW-TGTVGDKAGVFPSNYVR---------- 1056
Query: 68 VKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAERE 127
LKD+ G G T KT + P A V +Y A
Sbjct: 1057 ---LKDSEGSG-TAGKTGSLGKKPEI----------------------AQVIASYTATGP 1090
Query: 128 DELSLVKGSRVTVMEKCSDGWWRGSYNG-----QIGWFPSNYVLEEVDEAAAESPSFLSL 182
++L+L G + + +K GWW G QIGWFP+NYV SP +
Sbjct: 1091 EQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYV-------KLLSPGTSKI 1143
Query: 183 RKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARG 242
+ + V V+ +Y +++ ++EL F KG+ + V+ K DP+WWK G
Sbjct: 1144 TPTEPPKSTALAAVCQVIG-MYDYTAQNDDELAFNKGQIINVLNK--EDPDWWK-GEVNG 1199
Query: 243 QVGLVPKNYVVVLSD 257
QVGL P NYV + +D
Sbjct: 1200 QVGLFPSNYVKLTTD 1214
Score = 71.6 bits (174), Expect = 1e-12
Identities = 61/265 (23%), Positives = 111/265 (41%), Gaps = 39/265 (14%)
Query: 9 AKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSLV 68
A + + A++D L+ KN+ + +L+ WW + G+ P +YV+
Sbjct: 920 ALYPWRAKKDNHLNFNKNDVITVLEQQDMWW-FGEVQGQKGWFPKSYVK----------- 967
Query: 69 KNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAERED 128
L G R+ TS S + A+ + + A + Y + +
Sbjct: 968 ------LISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAM--YTYESSEQG 1019
Query: 129 ELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLSLRKGASL 188
+L+ +G + V +K D WW G+ + G FPSNYV + E + G +
Sbjct: 1020 DLTFQQGDVILVTKKDGD-WWTGTVGDKAGVFPSNYVRLKDSEGS-----------GTAG 1067
Query: 189 SNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCK-NARG---QV 244
G + + Q + +++ E+L G+ ++ + +N WW+ + ARG Q+
Sbjct: 1068 KTGSLGKKPEIAQVIASYTATGPEQLTLAPGQL--ILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 245 GLVPKNYVVVLSDGPA-LHPAHAPQ 268
G P NYV +LS G + + P P+
Sbjct: 1126 GWFPANYVKLLSPGTSKITPTEPPK 1150
Score = 66.2 bits (160), Expect = 5e-11
Identities = 50/185 (27%), Positives = 91/185 (49%), Gaps = 24/185 (12%)
Query: 78 GKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAEREDELSLVKGSR 137
G+ R++++ A+ T S+ + P G G +++ L A + + A++++ L+ K
Sbjct: 885 GQLRQRSAFTPATATGSSPS--PVLGQG-EKVEGLQAQAL--YPWRAKKDNHLNFNKNDV 939
Query: 138 VTVMEKCSDGWWRGSYNGQIGWFPSNYV---------LEEVDEAAAESPSFLS-LRKGAS 187
+TV+E+ D WW G GQ GWFP +YV +D ++ESP+ L + A+
Sbjct: 940 ITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAA 998
Query: 188 LSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLV 247
G + +Y + S + +L F++G+ + V +K D +WW + G+
Sbjct: 999 KPVVSGEEFI----AMYTYESSEQGDLTFQQGDVILVTKK---DGDWW-TGTVGDKAGVF 1050
Query: 248 PKNYV 252
P NYV
Sbjct: 1051 PSNYV 1055
Score = 41.2 bits (95), Expect = 0.002
Identities = 34/128 (26%), Positives = 57/128 (44%), Gaps = 9/128 (7%)
Query: 56 VERKNSLKKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEY-PANGSGADRIYDLNI 114
V++K+ +KG + +D LG + + A+ A P + AE P S + + +
Sbjct: 688 VKKKDGEEKGK--QEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYY 745
Query: 115 PAFVKFAYVAERE-----DELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEV 169
A F + E ++ +VKG V + GW G G+ GWFP+NY E++
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYA-EKI 804
Query: 170 DEAAAESP 177
E +P
Sbjct: 805 PENEVPAP 812
Score = 38.1 bits (87), Expect = 0.013
Identities = 20/52 (38%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 7 VIAKWDYTAQQDQELDIKKNERLWLLD-DSKTWWRVRNAANRTGYVPSNYVE 57
VI +DYTAQ D EL K + + +L+ + WW+ + G PSNYV+
Sbjct: 1160 VIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWK-GEVNGQVGLFPSNYVK 1210
Score = 33.9 bits (76), Expect = 0.25
Identities = 22/113 (19%), Positives = 51/113 (45%), Gaps = 5/113 (4%)
Query: 167 EEVDEAAAESPSFLSLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETM---- 222
+E + A ++P + + ++S + +V++ + LYPF S + +E+ + G+ +
Sbjct: 713 QEPAKPAVQAPWSTAEKGPLTISAQENVKVVYY-RALYPFESRSHDEITIQPGDIVMVKG 771
Query: 223 EVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALHPAHAPQISYTGPS 275
E +++ + W +G+ G P NY + + P S + P+
Sbjct: 772 EWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPA 824
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 87.4 bits (215), Expect = 2e-17
Identities = 69/255 (27%), Positives = 106/255 (41%), Gaps = 53/255 (20%)
Query: 8 IAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSL 67
IA + Y + + +L ++ + + + WW ++ G PSNYV
Sbjct: 1008 IAMYTYESSEQGDLTFQQGDVILVTKKDGDWW-TGTVGDKAGVFPSNYVR---------- 1056
Query: 68 VKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAERE 127
LKD+ G G T KT + P A V +Y A
Sbjct: 1057 ---LKDSEGSG-TAGKTGSLGKKPEI----------------------AQVIASYTATGP 1090
Query: 128 DELSLVKGSRVTVMEKCSDGWWRGSYNG-----QIGWFPSNYVLEEVDEAAAESPSFLSL 182
++L+L G + + +K GWW G QIGWFP+NYV SP +
Sbjct: 1091 EQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYV-------KLLSPGTSKI 1143
Query: 183 RKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARG 242
+ + V V+ +Y +++ ++EL F KG+ + V+ K DP+WWK G
Sbjct: 1144 TPTEPPKSTALAAVCQVIG-MYDYTAQNDDELAFNKGQIINVLNK--EDPDWWK-GEVNG 1199
Query: 243 QVGLVPKNYVVVLSD 257
QVGL P NYV + +D
Sbjct: 1200 QVGLFPSNYVKLTTD 1214
Score = 71.6 bits (174), Expect = 1e-12
Identities = 61/265 (23%), Positives = 111/265 (41%), Gaps = 39/265 (14%)
Query: 9 AKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSLV 68
A + + A++D L+ KN+ + +L+ WW + G+ P +YV+
Sbjct: 920 ALYPWRAKKDNHLNFNKNDVITVLEQQDMWW-FGEVQGQKGWFPKSYVK----------- 967
Query: 69 KNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAERED 128
L G R+ TS S + A+ + + A + Y + +
Sbjct: 968 ------LISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAM--YTYESSEQG 1019
Query: 129 ELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLSLRKGASL 188
+L+ +G + V +K D WW G+ + G FPSNYV + E + G +
Sbjct: 1020 DLTFQQGDVILVTKKDGD-WWTGTVGDKAGVFPSNYVRLKDSEGS-----------GTAG 1067
Query: 189 SNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCK-NARG---QV 244
G + + Q + +++ E+L G+ ++ + +N WW+ + ARG Q+
Sbjct: 1068 KTGSLGKKPEIAQVIASYTATGPEQLTLAPGQL--ILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 245 GLVPKNYVVVLSDGPA-LHPAHAPQ 268
G P NYV +LS G + + P P+
Sbjct: 1126 GWFPANYVKLLSPGTSKITPTEPPK 1150
Score = 66.2 bits (160), Expect = 5e-11
Identities = 50/185 (27%), Positives = 91/185 (49%), Gaps = 24/185 (12%)
Query: 78 GKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAEREDELSLVKGSR 137
G+ R++++ A+ T S+ + P G G +++ L A + + A++++ L+ K
Sbjct: 885 GQLRQRSAFTPATATGSSPS--PVLGQG-EKVEGLQAQAL--YPWRAKKDNHLNFNKNDV 939
Query: 138 VTVMEKCSDGWWRGSYNGQIGWFPSNYV---------LEEVDEAAAESPSFLS-LRKGAS 187
+TV+E+ D WW G GQ GWFP +YV +D ++ESP+ L + A+
Sbjct: 940 ITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAA 998
Query: 188 LSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLV 247
G + +Y + S + +L F++G+ + V +K D +WW + G+
Sbjct: 999 KPVVSGEEFI----AMYTYESSEQGDLTFQQGDVILVTKK---DGDWW-TGTVGDKAGVF 1050
Query: 248 PKNYV 252
P NYV
Sbjct: 1051 PSNYV 1055
Score = 41.2 bits (95), Expect = 0.002
Identities = 34/128 (26%), Positives = 57/128 (44%), Gaps = 9/128 (7%)
Query: 56 VERKNSLKKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEY-PANGSGADRIYDLNI 114
V++K+ +KG + +D LG + + A+ A P + AE P S + + +
Sbjct: 688 VKKKDGEEKGK--QEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYY 745
Query: 115 PAFVKFAYVAERE-----DELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEV 169
A F + E ++ +VKG V + GW G G+ GWFP+NY E++
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYA-EKI 804
Query: 170 DEAAAESP 177
E +P
Sbjct: 805 PENEVPAP 812
Score = 38.1 bits (87), Expect = 0.013
Identities = 20/52 (38%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 7 VIAKWDYTAQQDQELDIKKNERLWLLD-DSKTWWRVRNAANRTGYVPSNYVE 57
VI +DYTAQ D EL K + + +L+ + WW+ + G PSNYV+
Sbjct: 1160 VIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWK-GEVNGQVGLFPSNYVK 1210
Score = 33.9 bits (76), Expect = 0.25
Identities = 22/113 (19%), Positives = 51/113 (45%), Gaps = 5/113 (4%)
Query: 167 EEVDEAAAESPSFLSLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETM---- 222
+E + A ++P + + ++S + +V++ + LYPF S + +E+ + G+ +
Sbjct: 713 QEPAKPAVQAPWSTAEKGPLTISAQENVKVVYY-RALYPFESRSHDEITIQPGDIVMVKG 771
Query: 223 EVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALHPAHAPQISYTGPS 275
E +++ + W +G+ G P NY + + P S + P+
Sbjct: 772 EWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPA 824
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 85.5 bits (210), Expect = 7e-17
Identities = 53/168 (31%), Positives = 87/168 (51%), Gaps = 33/168 (19%)
Query: 203 LYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKN-ARGQVGLVPKNYVVVLSDGPAL 261
LY + S TE +L+F+KGE ++++ E D WW + + GQ G +P NYV
Sbjct: 92 LYDYESRTETDLSFKKGERLQIVNNTEGD--WWLAHSLSTGQTGYIPSNYV--------- 140
Query: 262 HPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAE-CALNERGVEGDFLIRDSESSPSDF 320
PS S EWY+G +TR ++E LN G FL+R+SE++ +
Sbjct: 141 -----------APSDS--IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAY 187
Query: 321 SVSL----KASGKN-KHFKVQLVDN--VYCIGQRRFHTMDELVEHYKK 361
+S+ A G N KH+K++ +D+ Y + +F+++ +LV +Y K
Sbjct: 188 CLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSK 235
Score = 46.2 bits (108), Expect = 5e-05
Identities = 20/58 (34%), Positives = 39/58 (67%), Gaps = 2/58 (3%)
Query: 8 IAKWDYTAQQDQELDIKKNERLWLLDDSK-TWWRVRN-AANRTGYVPSNYVERKNSLK 63
+A +DY ++ + +L KK ERL ++++++ WW + + +TGY+PSNYV +S++
Sbjct: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQ 147
Score = 37.7 bits (86), Expect = 0.017
Identities = 17/48 (35%), Positives = 24/48 (50%), Gaps = 2/48 (4%)
Query: 120 FAYVAEREDELSLVKGSRVTVMEKCSDGWW--RGSYNGQIGWFPSNYV 165
+ Y + E +LS KG R+ ++ WW GQ G+ PSNYV
Sbjct: 93 YDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 85.5 bits (210), Expect = 7e-17
Identities = 53/168 (31%), Positives = 87/168 (51%), Gaps = 33/168 (19%)
Query: 203 LYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKN-ARGQVGLVPKNYVVVLSDGPAL 261
LY + S TE +L+F+KGE ++++ E D WW + + GQ G +P NYV
Sbjct: 92 LYDYESRTETDLSFKKGERLQIVNNTEGD--WWLAHSLSTGQTGYIPSNYV--------- 140
Query: 262 HPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAE-CALNERGVEGDFLIRDSESSPSDF 320
PS S EWY+G +TR ++E LN G FL+R+SE++ +
Sbjct: 141 -----------APSDS--IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAY 187
Query: 321 SVSL----KASGKN-KHFKVQLVDN--VYCIGQRRFHTMDELVEHYKK 361
+S+ A G N KH+K++ +D+ Y + +F+++ +LV +Y K
Sbjct: 188 CLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSK 235
Score = 46.2 bits (108), Expect = 5e-05
Identities = 20/58 (34%), Positives = 39/58 (67%), Gaps = 2/58 (3%)
Query: 8 IAKWDYTAQQDQELDIKKNERLWLLDDSK-TWWRVRN-AANRTGYVPSNYVERKNSLK 63
+A +DY ++ + +L KK ERL ++++++ WW + + +TGY+PSNYV +S++
Sbjct: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQ 147
Score = 37.7 bits (86), Expect = 0.017
Identities = 17/48 (35%), Positives = 24/48 (50%), Gaps = 2/48 (4%)
Query: 120 FAYVAEREDELSLVKGSRVTVMEKCSDGWW--RGSYNGQIGWFPSNYV 165
+ Y + E +LS KG R+ ++ WW GQ G+ PSNYV
Sbjct: 93 YDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 83.2 bits (204), Expect = 4e-16
Identities = 50/163 (30%), Positives = 91/163 (55%), Gaps = 31/163 (19%)
Query: 204 YPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALHP 263
Y F + ++EL+F++G+ ++V+ + E D W+K + G+ G +PKNY+ + HP
Sbjct: 7 YDFKATADDELSFKRGDILKVLNE-ECDQNWYKAE-LNGKDGFIPKNYIEMKP-----HP 59
Query: 264 AHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVS 323
W++G + R +AE L+++ +G FLIR+SES+P DFS+S
Sbjct: 60 ---------------------WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLS 98
Query: 324 LKASGKNKHFKVQLVDNV--YCIGQRRFHTMDELVEHYKKAPI 364
+K +HFKV L D Y + +F++++ELV++++ +
Sbjct: 99 VKFGNDVQHFKV-LRDGAGKYFLWVVKFNSLNELVDYHRSTSV 140
Score = 57.0 bits (136), Expect = 3e-08
Identities = 59/249 (23%), Positives = 100/249 (40%), Gaps = 46/249 (18%)
Query: 8 IAKWDYTAQQDQELDIKKNERLWLLDDS--KTWWRVRNAANRTGYVPSNYVERKNSLKKG 65
IAK+D+ A D EL K+ + L +L++ + W++ + G++P NY+E K
Sbjct: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAE-LNGKDGFIPKNYIEMKPHPWFF 62
Query: 66 SLVKNLKDTLGLGKTRRKTS--ARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYV 123
+ K L K R + R++ P + G+ L A F +V
Sbjct: 63 GKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWV 122
Query: 124 AEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLSLR 183
+ LV R T + + N QI L ++++ + P++
Sbjct: 123 VKFNSLNELVDYHRSTSVSR----------NQQI-------FLRDIEQVP-QQPTY---- 160
Query: 184 KGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQ 243
VQ L+ F + EL F +G+ + V++ +DP WWK GQ
Sbjct: 161 ----------------VQALFDFDPQEDGELGFRRGDFIHVMDN--SDPNWWKGA-CHGQ 201
Query: 244 VGLVPKNYV 252
G+ P+NYV
Sbjct: 202 TGMFPRNYV 210
Score = 43.1 bits (100), Expect = 4e-04
Identities = 18/51 (35%), Positives = 30/51 (58%), Gaps = 1/51 (1%)
Query: 116 AFVKFAYVAEREDELSLVKGSRVTVM-EKCSDGWWRGSYNGQIGWFPSNYV 165
A K+ + A +DELS +G + V+ E+C W++ NG+ G+ P NY+
Sbjct: 3 AIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI 53
Score = 33.5 bits (75), Expect = 0.33
Identities = 17/54 (31%), Positives = 28/54 (51%)
Query: 7 VIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKN 60
V A +D+ Q+D EL ++ + + ++D+S W +TG P NYV N
Sbjct: 161 VQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVN 214
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 83.2 bits (204), Expect = 4e-16
Identities = 55/166 (33%), Positives = 87/166 (52%), Gaps = 33/166 (19%)
Query: 203 LYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKN-ARGQVGLVPKNYVVVLSDGPAL 261
LY + + T E+L+F+KGE ++I E D WW+ ++ A G+ G +P NYV
Sbjct: 99 LYDYEARTTEDLSFKKGERFQIINNTEGD--WWEARSIATGKNGYIPSNYVA-------- 148
Query: 262 HPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAE-CALNERGVEGDFLIRDSESSPSDF 320
PA + Q EWY+G + R AE LN G FL+R+SE++ +
Sbjct: 149 -PADSIQ-------------AEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAY 194
Query: 321 SVSLK----ASGKN-KHFKVQLVDN--VYCIGQRRFHTMDELVEHY 359
S+S++ G N KH+K++ +DN Y + +F T+ +LV+HY
Sbjct: 195 SLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY 240
Score = 49.3 bits (116), Expect = 6e-06
Identities = 22/60 (36%), Positives = 39/60 (65%), Gaps = 2/60 (3%)
Query: 6 IVIAKWDYTAQQDQELDIKKNERLWLLDDSK-TWWRVRN-AANRTGYVPSNYVERKNSLK 63
I +A +DY A+ ++L KK ER ++++++ WW R+ A + GY+PSNYV +S++
Sbjct: 95 IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQ 154
Score = 38.5 bits (88), Expect = 0.010
Identities = 22/71 (30%), Positives = 32/71 (45%), Gaps = 8/71 (11%)
Query: 97 AEYPANGSGADRIYDLNIPAFVKFAYVAEREDELSLVKGSRVTVMEKCSDGWW--RGSYN 154
+ YPA +G I+ + Y A ++LS KG R ++ WW R
Sbjct: 83 SSYPAGLTGGVTIF------VALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIAT 136
Query: 155 GQIGWFPSNYV 165
G+ G+ PSNYV
Sbjct: 137 GKNGYIPSNYV 147
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 81.3 bits (199), Expect = 1e-15
Identities = 52/172 (30%), Positives = 86/172 (50%), Gaps = 34/172 (19%)
Query: 199 VVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKN-ARGQVGLVPKNYVVVLSD 257
+V LY + ++ E+L+F+KG+ M V+E+ EWWK ++ A + G +P NYV +
Sbjct: 82 IVVALYDYEAIHHEDLSFQKGDQMVVLEE---SGEWWKARSLATRKEGYIPSNYVARVDS 138
Query: 258 GPALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERG-VEGDFLIRDSESS 316
EW++ ++R AE L G + G F+IRDSE++
Sbjct: 139 ----------------------LETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETT 176
Query: 317 PSDFSVSL-----KASGKNKHFKVQLVDN--VYCIGQRRFHTMDELVEHYKK 361
+S+S+ + KH+K++ +DN Y + F T+ ELV+HYKK
Sbjct: 177 KGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKK 228
Score = 60.5 bits (145), Expect = 2e-09
Identities = 26/63 (41%), Positives = 45/63 (71%), Gaps = 1/63 (1%)
Query: 2 TEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANR-TGYVPSNYVERKN 60
+E++IV+A +DY A ++L +K +++ +L++S WW+ R+ A R GY+PSNYV R +
Sbjct: 78 SEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVD 137
Query: 61 SLK 63
SL+
Sbjct: 138 SLE 140
Score = 34.7 bits (78), Expect = 0.15
Identities = 32/112 (28%), Positives = 54/112 (48%), Gaps = 10/112 (8%)
Query: 120 FAYVAEREDELSLVKGSRVTVMEKCSDGWW--RGSYNGQIGWFPSNYVLEEVDEAAAESP 177
+ Y A ++LS KG ++ V+E+ S WW R + G+ PSNYV VD E
Sbjct: 87 YDYEAIHHEDLSFQKGDQMVVLEE-SGEWWKARSLATRKEGYIPSNYV-ARVDSLETEEW 144
Query: 178 SFLSL-RKGA-----SLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETME 223
F + RK A + N GS ++ +T S++ + + +G+T++
Sbjct: 145 FFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVK 196
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 80.9 bits (198), Expect = 2e-15
Identities = 72/269 (26%), Positives = 113/269 (42%), Gaps = 51/269 (18%)
Query: 4 EVIVIAKWDYTAQQDQELDIKKNERL----WLLDDSKTWWRVRNAANRTGYVPSNYVERK 59
EV+V+A Y AQ++ EL + + + W+ ++ W R R G P
Sbjct: 2 EVLVLA--GYRAQKEDELSLAPGDVVRQVRWV--PARGWLR-GEFGGRYGLFPER----- 51
Query: 60 NSLKKGSLVKNLKDTL-GLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFV 118
LV+ + +TL G G+ RR AR +PA R +N
Sbjct: 52 -------LVQEIPETLRGSGEARRPRCARRRG--------HPAKHPRPQRWCKVN----- 91
Query: 119 KFAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYV------------- 165
F+Y E+ DEL L G V ++++ DGWW G NGQ+G FPSN+V
Sbjct: 92 -FSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGNP 150
Query: 166 -LEEVDEAAAESPSFLSLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEV 224
+ V P SL + Q V + L+ + +EL +G+ ++V
Sbjct: 151 DMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKV 210
Query: 225 IEKPENDPEWWKCKNARGQVGLVPKNYVV 253
+ K D WW+ +G+ G+ P N+V+
Sbjct: 211 LSKTTEDKGWWE-GECQGRRGVFPDNFVL 238
Score = 61.2 bits (147), Expect = 1e-09
Identities = 46/143 (32%), Positives = 70/143 (48%), Gaps = 12/143 (8%)
Query: 122 YVAEREDELSLVKGSRVTVMEKC-SDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSF- 179
Y A++EDELSL G V + + GW RG + G+ G FP V +E+ E S
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLV-QEIPETLRGSGEAR 67
Query: 180 ---LSLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWK 236
+ R+G + + R V + +S +EL + GE +E+I++ E+ WW
Sbjct: 68 RPRCARRRGHPAKHPRPQRWCKVN---FSYSPEQADELKLQAGEIVEMIKEIEDG--WWL 122
Query: 237 CKNARGQVGLVPKNYVVVLSDGP 259
K GQ+G P N+V +L GP
Sbjct: 123 GKK-NGQLGAFPSNFVELLDSGP 144
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 80.9 bits (198), Expect = 2e-15
Identities = 49/168 (29%), Positives = 82/168 (48%), Gaps = 33/168 (19%)
Query: 203 LYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKN-ARGQVGLVPKNYVVVLSDGPAL 261
LY + + TE++L+F KGE +++ E D WW+ ++ G+ G +P NYV +
Sbjct: 90 LYDYEARTEDDLSFHKGEKFQILNSSEGD--WWEARSLTTGETGYIPSNYVAPVDS---- 143
Query: 262 HPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERG-VEGDFLIRDSESSPSDF 320
EWY+G + R AE L G G FLIR+SE++ +
Sbjct: 144 ------------------IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAY 185
Query: 321 SVSLK-----ASGKNKHFKVQLVDN--VYCIGQRRFHTMDELVEHYKK 361
S+S++ KH+K++ +DN Y + +F T+ +LV+HY +
Sbjct: 186 SLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSE 233
Score = 46.6 bits (109), Expect = 4e-05
Identities = 22/64 (34%), Positives = 37/64 (57%), Gaps = 2/64 (3%)
Query: 2 TEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSK-TWWRVRN-AANRTGYVPSNYVERK 59
T + +A +DY A+ + +L K E+ +L+ S+ WW R+ TGY+PSNYV
Sbjct: 82 TGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV 141
Query: 60 NSLK 63
+S++
Sbjct: 142 DSIQ 145
Score = 44.3 bits (103), Expect = 2e-04
Identities = 34/109 (31%), Positives = 51/109 (46%), Gaps = 9/109 (8%)
Query: 120 FAYVAEREDELSLVKGSRVTVMEKCSDGWW--RGSYNGQIGWFPSNYVLEEVDEAAAESP 177
+ Y A ED+LS KG + ++ WW R G+ G+ PSNYV VD AE
Sbjct: 91 YDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYV-APVDSIQAEEW 149
Query: 178 SFLSL-RKGA-----SLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGE 220
F L RK A S N +G+ ++ +T S++ + + KG+
Sbjct: 150 YFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGD 198
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 80.9 bits (198), Expect = 2e-15
Identities = 49/168 (29%), Positives = 82/168 (48%), Gaps = 33/168 (19%)
Query: 203 LYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKN-ARGQVGLVPKNYVVVLSDGPAL 261
LY + + TE++L+F KGE +++ E D WW+ ++ G+ G +P NYV +
Sbjct: 90 LYDYEARTEDDLSFHKGEKFQILNSSEGD--WWEARSLTTGETGYIPSNYVAPVDS---- 143
Query: 262 HPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERG-VEGDFLIRDSESSPSDF 320
EWY+G + R AE L G G FLIR+SE++ +
Sbjct: 144 ------------------IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAY 185
Query: 321 SVSLK-----ASGKNKHFKVQLVDN--VYCIGQRRFHTMDELVEHYKK 361
S+S++ KH+K++ +DN Y + +F T+ +LV+HY +
Sbjct: 186 SLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSE 233
Score = 46.6 bits (109), Expect = 4e-05
Identities = 22/64 (34%), Positives = 37/64 (57%), Gaps = 2/64 (3%)
Query: 2 TEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSK-TWWRVRN-AANRTGYVPSNYVERK 59
T + +A +DY A+ + +L K E+ +L+ S+ WW R+ TGY+PSNYV
Sbjct: 82 TGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV 141
Query: 60 NSLK 63
+S++
Sbjct: 142 DSIQ 145
Score = 44.3 bits (103), Expect = 2e-04
Identities = 34/109 (31%), Positives = 51/109 (46%), Gaps = 9/109 (8%)
Query: 120 FAYVAEREDELSLVKGSRVTVMEKCSDGWW--RGSYNGQIGWFPSNYVLEEVDEAAAESP 177
+ Y A ED+LS KG + ++ WW R G+ G+ PSNYV VD AE
Sbjct: 91 YDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYV-APVDSIQAEEW 149
Query: 178 SFLSL-RKGA-----SLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGE 220
F L RK A S N +G+ ++ +T S++ + + KG+
Sbjct: 150 YFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGD 198
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 80.5 bits (197), Expect = 2e-15
Identities = 49/166 (29%), Positives = 81/166 (48%), Gaps = 33/166 (19%)
Query: 203 LYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKN-ARGQVGLVPKNYVVVLSDGPAL 261
LY + + TE++L+F KGE +++ E D WW+ ++ G+ G +P NYV +
Sbjct: 90 LYDYEARTEDDLSFHKGEKFQILNSSEGD--WWEARSLTTGETGYIPSNYVAPVDS---- 143
Query: 262 HPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERG-VEGDFLIRDSESSPSDF 320
EWY+G + R AE L G G FLIR+SE++ +
Sbjct: 144 ------------------IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAY 185
Query: 321 SVSLK-----ASGKNKHFKVQLVDN--VYCIGQRRFHTMDELVEHY 359
S+S++ KH+K++ +DN Y + +F T+ +LV+HY
Sbjct: 186 SLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHY 231
Score = 46.6 bits (109), Expect = 4e-05
Identities = 22/64 (34%), Positives = 37/64 (57%), Gaps = 2/64 (3%)
Query: 2 TEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSK-TWWRVRN-AANRTGYVPSNYVERK 59
T + +A +DY A+ + +L K E+ +L+ S+ WW R+ TGY+PSNYV
Sbjct: 82 TGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV 141
Query: 60 NSLK 63
+S++
Sbjct: 142 DSIQ 145
Score = 44.3 bits (103), Expect = 2e-04
Identities = 34/109 (31%), Positives = 51/109 (46%), Gaps = 9/109 (8%)
Query: 120 FAYVAEREDELSLVKGSRVTVMEKCSDGWW--RGSYNGQIGWFPSNYVLEEVDEAAAESP 177
+ Y A ED+LS KG + ++ WW R G+ G+ PSNYV VD AE
Sbjct: 91 YDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYV-APVDSIQAEEW 149
Query: 178 SFLSL-RKGA-----SLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGE 220
F L RK A S N +G+ ++ +T S++ + + KG+
Sbjct: 150 YFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGD 198
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 78.2 bits (191), Expect = 1e-14
Identities = 49/159 (30%), Positives = 78/159 (49%), Gaps = 27/159 (16%)
Query: 203 LYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALH 262
LY F + + L+ KGE + V+ N EW + + GQ G VP NY+ ++
Sbjct: 69 LYDFVASGDNTLSITKGEKLRVLGYNHNG-EWCEAQTKNGQ-GWVPSNYITPVNS----- 121
Query: 263 PAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSV 322
WY+G V+R+ AE L+ G+ G FL+R+SESSP S+
Sbjct: 122 -----------------LEKHSWYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSI 163
Query: 323 SLKASGKNKHFKVQLVDN--VYCIGQRRFHTMDELVEHY 359
SL+ G+ H+++ + +Y + RF+T+ ELV H+
Sbjct: 164 SLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHH 202
Score = 40.8 bits (94), Expect = 0.002
Identities = 23/62 (37%), Positives = 33/62 (53%), Gaps = 1/62 (1%)
Query: 6 IVIAKWDYTAQQDQELDIKKNERLWLLDDSKTW-WRVRNAANRTGYVPSNYVERKNSLKK 64
+ +A +D+ A D L I K E+L +L + W N G+VPSNY+ NSL+K
Sbjct: 65 LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEK 124
Query: 65 GS 66
S
Sbjct: 125 HS 126
Score = 35.0 bits (79), Expect = 0.11
Identities = 18/48 (37%), Positives = 29/48 (60%), Gaps = 3/48 (6%)
Query: 120 FAYVAEREDELSLVKGSRVTVMEKCSDGWW--RGSYNGQIGWFPSNYV 165
+ +VA ++ LS+ KG ++ V+ +G W + NGQ GW PSNY+
Sbjct: 70 YDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GWVPSNYI 116
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 78.2 bits (191), Expect = 1e-14
Identities = 49/159 (30%), Positives = 78/159 (49%), Gaps = 27/159 (16%)
Query: 203 LYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALH 262
LY F + + L+ KGE + V+ N EW + + GQ G VP NY+ ++
Sbjct: 88 LYDFVASGDNTLSITKGEKLRVLGYNHNG-EWCEAQTKNGQ-GWVPSNYITPVNS----- 140
Query: 263 PAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSV 322
WY+G V+R+ AE L+ G+ G FL+R+SESSP S+
Sbjct: 141 -----------------LEKHSWYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSI 182
Query: 323 SLKASGKNKHFKVQLVDN--VYCIGQRRFHTMDELVEHY 359
SL+ G+ H+++ + +Y + RF+T+ ELV H+
Sbjct: 183 SLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHH 221
Score = 40.8 bits (94), Expect = 0.002
Identities = 23/62 (37%), Positives = 33/62 (53%), Gaps = 1/62 (1%)
Query: 6 IVIAKWDYTAQQDQELDIKKNERLWLLDDSKTW-WRVRNAANRTGYVPSNYVERKNSLKK 64
+ +A +D+ A D L I K E+L +L + W N G+VPSNY+ NSL+K
Sbjct: 84 LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEK 143
Query: 65 GS 66
S
Sbjct: 144 HS 145
Score = 35.0 bits (79), Expect = 0.11
Identities = 18/48 (37%), Positives = 29/48 (60%), Gaps = 3/48 (6%)
Query: 120 FAYVAEREDELSLVKGSRVTVMEKCSDGWW--RGSYNGQIGWFPSNYV 165
+ +VA ++ LS+ KG ++ V+ +G W + NGQ GW PSNY+
Sbjct: 89 YDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GWVPSNYI 135
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 77.4 bits (189), Expect = 2e-14
Identities = 48/166 (28%), Positives = 82/166 (49%), Gaps = 33/166 (19%)
Query: 203 LYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKN-ARGQVGLVPKNYVVVLSDGPAL 261
LY + + TE++L F KGE ++ E D WW+ ++ + G+ G +P NYV +
Sbjct: 85 LYDYEARTEDDLTFTKGEKFHILNNTEGD--WWEARSLSSGKTGCIPSNYVAPVDS---- 138
Query: 262 HPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERG-VEGDFLIRDSESSPSDF 320
EWY+G + R AE L G +G FLIR+SE++ +
Sbjct: 139 ------------------IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY 180
Query: 321 SVSLKASGKN-----KHFKVQLVD--NVYCIGQRRFHTMDELVEHY 359
S+S++ + KH+K++ +D Y + +F+++ ELV+HY
Sbjct: 181 SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHY 226
Score = 43.5 bits (101), Expect = 3e-04
Identities = 20/60 (33%), Positives = 39/60 (65%), Gaps = 2/60 (3%)
Query: 6 IVIAKWDYTAQQDQELDIKKNERLWLLDDSK-TWWRVRN-AANRTGYVPSNYVERKNSLK 63
+ IA +DY A+ + +L K E+ +L++++ WW R+ ++ +TG +PSNYV +S++
Sbjct: 81 LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQ 140
Score = 41.2 bits (95), Expect = 0.002
Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 9/109 (8%)
Query: 120 FAYVAEREDELSLVKGSRVTVMEKCSDGWW--RGSYNGQIGWFPSNYVLEEVDEAAAESP 177
+ Y A ED+L+ KG + ++ WW R +G+ G PSNYV VD AE
Sbjct: 86 YDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYV-APVDSIQAEEW 144
Query: 178 SFLSL-RKGA-----SLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGE 220
F + RK A S N QG+ ++ +T S++ + + +G+
Sbjct: 145 YFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGD 193
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 77.4 bits (189), Expect = 2e-14
Identities = 48/166 (28%), Positives = 82/166 (49%), Gaps = 33/166 (19%)
Query: 203 LYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKN-ARGQVGLVPKNYVVVLSDGPAL 261
LY + + TE++L F KGE ++ E D WW+ ++ + G+ G +P NYV +
Sbjct: 85 LYDYEARTEDDLTFTKGEKFHILNNTEGD--WWEARSLSSGKTGCIPSNYVAPVDS---- 138
Query: 262 HPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERG-VEGDFLIRDSESSPSDF 320
EWY+G + R AE L G +G FLIR+SE++ +
Sbjct: 139 ------------------IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY 180
Query: 321 SVSLKASGKN-----KHFKVQLVD--NVYCIGQRRFHTMDELVEHY 359
S+S++ + KH+K++ +D Y + +F+++ ELV+HY
Sbjct: 181 SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHY 226
Score = 43.5 bits (101), Expect = 3e-04
Identities = 20/60 (33%), Positives = 39/60 (65%), Gaps = 2/60 (3%)
Query: 6 IVIAKWDYTAQQDQELDIKKNERLWLLDDSK-TWWRVRN-AANRTGYVPSNYVERKNSLK 63
+ IA +DY A+ + +L K E+ +L++++ WW R+ ++ +TG +PSNYV +S++
Sbjct: 81 LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQ 140
Score = 41.2 bits (95), Expect = 0.002
Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 9/109 (8%)
Query: 120 FAYVAEREDELSLVKGSRVTVMEKCSDGWW--RGSYNGQIGWFPSNYVLEEVDEAAAESP 177
+ Y A ED+L+ KG + ++ WW R +G+ G PSNYV VD AE
Sbjct: 86 YDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYV-APVDSIQAEEW 144
Query: 178 SFLSL-RKGA-----SLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGE 220
F + RK A S N QG+ ++ +T S++ + + +G+
Sbjct: 145 YFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGD 193
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 77.4 bits (189), Expect = 2e-14
Identities = 48/166 (28%), Positives = 82/166 (49%), Gaps = 33/166 (19%)
Query: 203 LYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKN-ARGQVGLVPKNYVVVLSDGPAL 261
LY + + TE++L F KGE ++ E D WW+ ++ + G+ G +P NYV +
Sbjct: 85 LYDYEARTEDDLTFTKGEKFHILNNTEGD--WWEARSLSSGKTGCIPSNYVAPVDS---- 138
Query: 262 HPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERG-VEGDFLIRDSESSPSDF 320
EWY+G + R AE L G +G FLIR+SE++ +
Sbjct: 139 ------------------IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY 180
Query: 321 SVSLKASGKN-----KHFKVQLVD--NVYCIGQRRFHTMDELVEHY 359
S+S++ + KH+K++ +D Y + +F+++ ELV+HY
Sbjct: 181 SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHY 226
Score = 43.5 bits (101), Expect = 3e-04
Identities = 20/60 (33%), Positives = 39/60 (65%), Gaps = 2/60 (3%)
Query: 6 IVIAKWDYTAQQDQELDIKKNERLWLLDDSK-TWWRVRN-AANRTGYVPSNYVERKNSLK 63
+ IA +DY A+ + +L K E+ +L++++ WW R+ ++ +TG +PSNYV +S++
Sbjct: 81 LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQ 140
Score = 41.2 bits (95), Expect = 0.002
Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 9/109 (8%)
Query: 120 FAYVAEREDELSLVKGSRVTVMEKCSDGWW--RGSYNGQIGWFPSNYVLEEVDEAAAESP 177
+ Y A ED+L+ KG + ++ WW R +G+ G PSNYV VD AE
Sbjct: 86 YDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYV-APVDSIQAEEW 144
Query: 178 SFLSL-RKGA-----SLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGE 220
F + RK A S N QG+ ++ +T S++ + + +G+
Sbjct: 145 YFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGD 193
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 77.4 bits (189), Expect = 2e-14
Identities = 63/248 (25%), Positives = 114/248 (45%), Gaps = 44/248 (17%)
Query: 12 DYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSLVKNL 71
D+ A+Q +L++ E ++LL+ T W N N+ G P+NYV+ + +G
Sbjct: 446 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEG------ 499
Query: 72 KDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAEREDELS 131
G GK +S + GS +F Y+ E++DELS
Sbjct: 500 ----GNGKRECVSS-------------HCVKGS----------RCVARFEYIGEQKDELS 532
Query: 132 LVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLS------LRKG 185
+G + + E ++ W RG G+ G FP N+V E V++ + LS +K
Sbjct: 533 FSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFV-EPVEDYPTSGANVLSTKVPLKTKKE 591
Query: 186 ASLSNGQ-GSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQV 244
S SN Q S + L+ F++ T ++L+F++G+ ++++E+ ++D W + +
Sbjct: 592 DSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD---WCRGRLQDRE 648
Query: 245 GLVPKNYV 252
G+ P +V
Sbjct: 649 GIFPAVFV 656
Score = 76.6 bits (187), Expect = 3e-14
Identities = 64/249 (25%), Positives = 109/249 (43%), Gaps = 39/249 (15%)
Query: 8 IAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLK-KGS 66
+A+++Y +Q EL + E + L + W RTG P N+VE G+
Sbjct: 518 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGA 577
Query: 67 LVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAER 126
V + K L KT+++ S + S S AE+ ++ AE
Sbjct: 578 NVLSTKVPL---KTKKEDSGSN-SQVNSLPAEW----------------CEALHSFTAET 617
Query: 127 EDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLSLRKGA 186
D+LS +G R+ ++E+ W RG + G FP+ + V AE+ S L++
Sbjct: 618 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVF----VRPCPAEAKSMLAI---- 669
Query: 187 SLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGL 246
+ G+ ++ LY F E+EL+F+ G+ + +E ++D W G+ G+
Sbjct: 670 -VPKGRKAK------ALYDFRGENEDELSFKAGDIITELESVDDD---WMSGELMGKSGI 719
Query: 247 VPKNYVVVL 255
PKNY+ L
Sbjct: 720 FPKNYIQFL 728
Score = 65.5 bits (158), Expect = 8e-11
Identities = 50/161 (31%), Positives = 77/161 (47%), Gaps = 12/161 (7%)
Query: 100 PANGSGADRIYDLNIP-AFVKFAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIG 158
P + S A + D P A V + AE+ D+L+L G V ++EK W+RG+ QIG
Sbjct: 424 PNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIG 483
Query: 159 WFPSNYVLEEVDEAAAESPSFLSLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEK 218
FP+NYV +D + R+ S +GSR + + + ++EL+F +
Sbjct: 484 IFPANYVKVIIDIPEGGN----GKRECVSSHCVKGSRCV----ARFEYIGEQKDELSFSE 535
Query: 219 GETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGP 259
G E+I E E W RG+ G+ P N+V + D P
Sbjct: 536 G---EIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYP 573
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 77.4 bits (189), Expect = 2e-14
Identities = 63/248 (25%), Positives = 114/248 (45%), Gaps = 44/248 (17%)
Query: 12 DYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSLVKNL 71
D+ A+Q +L++ E ++LL+ T W N N+ G P+NYV+ + +G
Sbjct: 482 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEG------ 535
Query: 72 KDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAEREDELS 131
G GK +S + GS +F Y+ E++DELS
Sbjct: 536 ----GNGKRECVSS-------------HCVKGS----------RCVARFEYIGEQKDELS 568
Query: 132 LVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLS------LRKG 185
+G + + E ++ W RG G+ G FP N+V E V++ + LS +K
Sbjct: 569 FSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFV-EPVEDYPTSGANVLSTKVPLKTKKE 627
Query: 186 ASLSNGQ-GSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQV 244
S SN Q S + L+ F++ T ++L+F++G+ ++++E+ ++D W + +
Sbjct: 628 DSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD---WCRGRLQDRE 684
Query: 245 GLVPKNYV 252
G+ P +V
Sbjct: 685 GIFPAVFV 692
Score = 76.6 bits (187), Expect = 3e-14
Identities = 64/249 (25%), Positives = 109/249 (43%), Gaps = 39/249 (15%)
Query: 8 IAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLK-KGS 66
+A+++Y +Q EL + E + L + W RTG P N+VE G+
Sbjct: 554 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGA 613
Query: 67 LVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAER 126
V + K L KT+++ S + S S AE+ ++ AE
Sbjct: 614 NVLSTKVPL---KTKKEDSGSN-SQVNSLPAEW----------------CEALHSFTAET 653
Query: 127 EDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLSLRKGA 186
D+LS +G R+ ++E+ W RG + G FP+ + V AE+ S L++
Sbjct: 654 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVF----VRPCPAEAKSMLAI---- 705
Query: 187 SLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGL 246
+ G+ ++ LY F E+EL+F+ G+ + +E ++D W G+ G+
Sbjct: 706 -VPKGRKAK------ALYDFRGENEDELSFKAGDIITELESVDDD---WMSGELMGKSGI 755
Query: 247 VPKNYVVVL 255
PKNY+ L
Sbjct: 756 FPKNYIQFL 764
Score = 65.5 bits (158), Expect = 8e-11
Identities = 50/161 (31%), Positives = 77/161 (47%), Gaps = 12/161 (7%)
Query: 100 PANGSGADRIYDLNIP-AFVKFAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIG 158
P + S A + D P A V + AE+ D+L+L G V ++EK W+RG+ QIG
Sbjct: 460 PNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIG 519
Query: 159 WFPSNYVLEEVDEAAAESPSFLSLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEK 218
FP+NYV +D + R+ S +GSR + + + ++EL+F +
Sbjct: 520 IFPANYVKVIIDIPEGGN----GKRECVSSHCVKGSRCV----ARFEYIGEQKDELSFSE 571
Query: 219 GETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGP 259
G E+I E E W RG+ G+ P N+V + D P
Sbjct: 572 G---EIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYP 609
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 77.4 bits (189), Expect = 2e-14
Identities = 63/248 (25%), Positives = 114/248 (45%), Gaps = 44/248 (17%)
Query: 12 DYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSLVKNL 71
D+ A+Q +L++ E ++LL+ T W N N+ G P+NYV+ + +G
Sbjct: 505 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEG------ 558
Query: 72 KDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAEREDELS 131
G GK +S + GS +F Y+ E++DELS
Sbjct: 559 ----GNGKRECVSS-------------HCVKGS----------RCVARFEYIGEQKDELS 591
Query: 132 LVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLS------LRKG 185
+G + + E ++ W RG G+ G FP N+V E V++ + LS +K
Sbjct: 592 FSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFV-EPVEDYPTSGANVLSTKVPLKTKKE 650
Query: 186 ASLSNGQ-GSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQV 244
S SN Q S + L+ F++ T ++L+F++G+ ++++E+ ++D W + +
Sbjct: 651 DSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD---WCRGRLQDRE 707
Query: 245 GLVPKNYV 252
G+ P +V
Sbjct: 708 GIFPAVFV 715
Score = 76.6 bits (187), Expect = 3e-14
Identities = 64/249 (25%), Positives = 109/249 (43%), Gaps = 39/249 (15%)
Query: 8 IAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLK-KGS 66
+A+++Y +Q EL + E + L + W RTG P N+VE G+
Sbjct: 577 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGA 636
Query: 67 LVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAER 126
V + K L KT+++ S + S S AE+ ++ AE
Sbjct: 637 NVLSTKVPL---KTKKEDSGSN-SQVNSLPAEW----------------CEALHSFTAET 676
Query: 127 EDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLSLRKGA 186
D+LS +G R+ ++E+ W RG + G FP+ + V AE+ S L++
Sbjct: 677 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVF----VRPCPAEAKSMLAI---- 728
Query: 187 SLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGL 246
+ G+ ++ LY F E+EL+F+ G+ + +E ++D W G+ G+
Sbjct: 729 -VPKGRKAK------ALYDFRGENEDELSFKAGDIITELESVDDD---WMSGELMGKSGI 778
Query: 247 VPKNYVVVL 255
PKNY+ L
Sbjct: 779 FPKNYIQFL 787
Score = 65.5 bits (158), Expect = 8e-11
Identities = 50/161 (31%), Positives = 77/161 (47%), Gaps = 12/161 (7%)
Query: 100 PANGSGADRIYDLNIP-AFVKFAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIG 158
P + S A + D P A V + AE+ D+L+L G V ++EK W+RG+ QIG
Sbjct: 483 PNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIG 542
Query: 159 WFPSNYVLEEVDEAAAESPSFLSLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEK 218
FP+NYV +D + R+ S +GSR + + + ++EL+F +
Sbjct: 543 IFPANYVKVIIDIPEGGN----GKRECVSSHCVKGSRCV----ARFEYIGEQKDELSFSE 594
Query: 219 GETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGP 259
G E+I E E W RG+ G+ P N+V + D P
Sbjct: 595 G---EIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYP 632
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 76.6 bits (187), Expect = 3e-14
Identities = 45/157 (28%), Positives = 77/157 (49%), Gaps = 19/157 (12%)
Query: 204 YPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALHP 263
Y F E++L F KG+ + ++ + DP W+K KN G+ G++P NYV
Sbjct: 18 YNFHGTAEQDLPFCKGDVLTIVAVTK-DPNWYKAKNKVGREGIIPANYVQ---------- 66
Query: 264 AHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVS 323
G + + + W++G +TR QAE L G FL+R+S + P D+++
Sbjct: 67 ------KREGVKAGTKLSLMPWFHGKITREQAERLLYPPET-GLFLVRESTNYPGDYTLC 119
Query: 324 LKASGKNKHFKVQLVDNVYCIGQR-RFHTMDELVEHY 359
+ GK +H+++ + I + F + +LVEHY
Sbjct: 120 VSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHY 156
Score = 42.4 bits (98), Expect = 7e-04
Identities = 18/61 (29%), Positives = 37/61 (60%), Gaps = 2/61 (3%)
Query: 8 IAKWDYTAQQDQELDIKKNERLWLLDDSK--TWWRVRNAANRTGYVPSNYVERKNSLKKG 65
IAK+++ +Q+L K + L ++ +K W++ +N R G +P+NYV+++ +K G
Sbjct: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
Query: 66 S 66
+
Sbjct: 75 T 75
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 76.6 bits (187), Expect = 3e-14
Identities = 45/157 (28%), Positives = 77/157 (49%), Gaps = 19/157 (12%)
Query: 204 YPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALHP 263
Y F E++L F KG+ + ++ + DP W+K KN G+ G++P NYV
Sbjct: 18 YNFHGTAEQDLPFCKGDVLTIVAVTK-DPNWYKAKNKVGREGIIPANYVQ---------- 66
Query: 264 AHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVS 323
G + + + W++G +TR QAE L G FL+R+S + P D+++
Sbjct: 67 ------KREGVKAGTKLSLMPWFHGKITREQAERLLYPPET-GLFLVRESTNYPGDYTLC 119
Query: 324 LKASGKNKHFKVQLVDNVYCIGQR-RFHTMDELVEHY 359
+ GK +H+++ + I + F + +LVEHY
Sbjct: 120 VSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHY 156
Score = 42.4 bits (98), Expect = 7e-04
Identities = 18/61 (29%), Positives = 37/61 (60%), Gaps = 2/61 (3%)
Query: 8 IAKWDYTAQQDQELDIKKNERLWLLDDSK--TWWRVRNAANRTGYVPSNYVERKNSLKKG 65
IAK+++ +Q+L K + L ++ +K W++ +N R G +P+NYV+++ +K G
Sbjct: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
Query: 66 S 66
+
Sbjct: 75 T 75
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 76.3 bits (186), Expect = 4e-14
Identities = 49/159 (30%), Positives = 76/159 (47%), Gaps = 27/159 (16%)
Query: 203 LYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALH 262
LY F + + L+ KGE + V+ +N EW + ++ GQ G VP NY+ ++
Sbjct: 100 LYDFVASGDNTLSITKGEKLRVLGYNQNG-EWSEVRSKNGQ-GWVPSNYITPVNS----- 152
Query: 263 PAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSV 322
WY+G V+R AE L+ + G FL+R+SESSP S+
Sbjct: 153 -----------------LEKHSWYHGPVSRSAAEYLLSSL-INGSFLVRESESSPGQLSI 194
Query: 323 SLKASGKNKHFKVQLV--DNVYCIGQRRFHTMDELVEHY 359
SL+ G+ H+++ VY + RF T+ ELV H+
Sbjct: 195 SLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHH 233
Score = 42.7 bits (99), Expect = 5e-04
Identities = 25/63 (39%), Positives = 37/63 (58%), Gaps = 3/63 (4%)
Query: 6 IVIAKWDYTAQQDQELDIKKNERLWLL--DDSKTWWRVRNAANRTGYVPSNYVERKNSLK 63
+ +A +D+ A D L I K E+L +L + + W VR+ N G+VPSNY+ NSL+
Sbjct: 96 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSK-NGQGWVPSNYITPVNSLE 154
Query: 64 KGS 66
K S
Sbjct: 155 KHS 157
Score = 36.6 bits (83), Expect = 0.038
Identities = 19/48 (39%), Positives = 29/48 (60%), Gaps = 3/48 (6%)
Query: 120 FAYVAEREDELSLVKGSRVTVMEKCSDGWWR--GSYNGQIGWFPSNYV 165
+ +VA ++ LS+ KG ++ V+ +G W S NGQ GW PSNY+
Sbjct: 101 YDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYI 147
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,004,905
Number of Sequences: 37866
Number of extensions: 696032
Number of successful extensions: 2632
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 252
Number of HSP's successfully gapped in prelim test: 104
Number of HSP's that attempted gapping in prelim test: 1524
Number of HSP's gapped (non-prelim): 856
length of query: 380
length of database: 18,247,518
effective HSP length: 104
effective length of query: 276
effective length of database: 14,309,454
effective search space: 3949409304
effective search space used: 3949409304
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.