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Search of human proteins with 52145305
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|52145305 patched 2 [Homo sapiens]
(1203 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|52145305 patched 2 [Homo sapiens] 2418 0.0
gi|134254446 patched isoform L [Homo sapiens] 1279 0.0
gi|134254432 patched isoform L' [Homo sapiens] 1278 0.0
gi|134254466 patched isoform M [Homo sapiens] 1278 0.0
gi|134254450 patched isoform S [Homo sapiens] 1167 0.0
gi|134254435 patched isoform S [Homo sapiens] 1167 0.0
gi|134254468 patched isoform S [Homo sapiens] 1167 0.0
gi|134254452 patched isoform S [Homo sapiens] 1167 0.0
gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens] 120 6e-27
gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapi... 110 8e-24
gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo sapi... 110 8e-24
gi|194018513 patched domain containing 3 [Homo sapiens] 79 2e-14
gi|66932902 SREBF chaperone protein [Homo sapiens] 73 2e-12
gi|149274653 patched domain containing 2 [Homo sapiens] 68 6e-11
gi|148277106 hypothetical protein LOC442213 [Homo sapiens] 67 8e-11
gi|148271104 patched domain containing 1 [Homo sapiens] 64 9e-10
gi|25952134 dispatched A [Homo sapiens] 46 2e-04
gi|85815829 SH3-domain binding protein 1 [Homo sapiens] 40 0.010
gi|25121980 dispatched B [Homo sapiens] 40 0.017
gi|21536320 heterogeneous nuclear ribonucleoprotein U-like 1 iso... 39 0.030
gi|21536326 heterogeneous nuclear ribonucleoprotein U-like 1 iso... 39 0.030
gi|39812378 RAN binding protein 9 [Homo sapiens] 38 0.066
gi|14270490 protocadherin gamma subfamily B, 1 isoform 2 precurs... 37 0.087
gi|11128037 protocadherin gamma subfamily B, 1 isoform 1 precurs... 37 0.087
gi|192807286 zinc finger and BTB domain containing 4 [Homo sapiens] 37 0.15
gi|192807284 zinc finger and BTB domain containing 4 [Homo sapiens] 37 0.15
gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens] 36 0.19
gi|14270505 protocadherin gamma subfamily B, 5 isoform 2 precurs... 36 0.25
gi|11128031 protocadherin gamma subfamily B, 5 isoform 1 precurs... 36 0.25
gi|208431781 cyclic nucleotide gated channel beta 1 isoform b [H... 35 0.56
>gi|52145305 patched 2 [Homo sapiens]
Length = 1203
Score = 2418 bits (6266), Expect = 0.0
Identities = 1203/1203 (100%), Positives = 1203/1203 (100%)
Query: 1 MTRSPPLRELPPSYTPPARTAAPQILAGSLKAPLWLRAYFQGLLFSLGCGIQRHCGKVLF 60
MTRSPPLRELPPSYTPPARTAAPQILAGSLKAPLWLRAYFQGLLFSLGCGIQRHCGKVLF
Sbjct: 1 MTRSPPLRELPPSYTPPARTAAPQILAGSLKAPLWLRAYFQGLLFSLGCGIQRHCGKVLF 60
Query: 61 LGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELHYTKEKLGEEAAYTSQMLIQTAR 120
LGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELHYTKEKLGEEAAYTSQMLIQTAR
Sbjct: 61 LGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELHYTKEKLGEEAAYTSQMLIQTAR 120
Query: 121 QEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLIENGMIERMIEKL 180
QEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLIENGMIERMIEKL
Sbjct: 121 QEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLIENGMIERMIEKL 180
Query: 181 FPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFASLEGFRELLDK 240
FPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFASLEGFRELLDK
Sbjct: 181 FPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFASLEGFRELLDK 240
Query: 241 AQVGQAYVGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSHKFMHWQEELLLG 300
AQVGQAYVGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSHKFMHWQEELLLG
Sbjct: 241 AQVGQAYVGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSHKFMHWQEELLLG 300
Query: 301 GMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFV 360
GMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFV
Sbjct: 301 GMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFV 360
Query: 361 QLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTMLRWDCAQ 420
QLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTMLRWDCAQ
Sbjct: 361 QLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTMLRWDCAQ 420
Query: 421 SQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTE 480
SQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTE
Sbjct: 421 SQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTE 480
Query: 481 ALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFV 540
ALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFV
Sbjct: 481 ALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFV 540
Query: 541 AVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQILPQELGDGTVPVGIAHLTATV 600
AVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQILPQELGDGTVPVGIAHLTATV
Sbjct: 541 AVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQILPQELGDGTVPVGIAHLTATV 600
Query: 601 QAFTHCEASSQHVVTILPPQAHLVPPPSDPLGSELFSPGGSTRDLLGQEEETRQKAACKS 660
QAFTHCEASSQHVVTILPPQAHLVPPPSDPLGSELFSPGGSTRDLLGQEEETRQKAACKS
Sbjct: 601 QAFTHCEASSQHVVTILPPQAHLVPPPSDPLGSELFSPGGSTRDLLGQEEETRQKAACKS 660
Query: 661 LPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRG 720
LPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRG
Sbjct: 661 LPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRG 720
Query: 721 TKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRT 780
TKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRT
Sbjct: 721 TKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRT 780
Query: 781 WLHYYRNWLQGIQAAFDQDWASGRITRHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLT 840
WLHYYRNWLQGIQAAFDQDWASGRITRHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLT
Sbjct: 781 WLHYYRNWLQGIQAAFDQDWASGRITRHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLT 840
Query: 841 TRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGENLRIP 900
TRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGENLRIP
Sbjct: 841 TRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGENLRIP 900
Query: 901 PAQPLEFAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGL 960
PAQPLEFAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGL
Sbjct: 901 PAQPLEFAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGL 960
Query: 961 RRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVV 1020
RRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVV
Sbjct: 961 RRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVV 1020
Query: 1021 ILVASVGIGVEFTVHVALGFLTTQGSRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSH 1080
ILVASVGIGVEFTVHVALGFLTTQGSRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSH
Sbjct: 1021 ILVASVGIGVEFTVHVALGFLTTQGSRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSH 1080
Query: 1081 FDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEVIQMYKESPEILSPPAPQGGG 1140
FDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEVIQMYKESPEILSPPAPQGGG
Sbjct: 1081 FDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEVIQMYKESPEILSPPAPQGGG 1140
Query: 1141 LRWGASSSLPQSFARVTTSMTVAIHPPPLPGAYIHPAPDEPPWSPAATSSGNLSSRGPGP 1200
LRWGASSSLPQSFARVTTSMTVAIHPPPLPGAYIHPAPDEPPWSPAATSSGNLSSRGPGP
Sbjct: 1141 LRWGASSSLPQSFARVTTSMTVAIHPPPLPGAYIHPAPDEPPWSPAATSSGNLSSRGPGP 1200
Query: 1201 ATG 1203
ATG
Sbjct: 1201 ATG 1203
>gi|134254446 patched isoform L [Homo sapiens]
Length = 1447
Score = 1279 bits (3310), Expect = 0.0
Identities = 642/1136 (56%), Positives = 836/1136 (73%), Gaps = 31/1136 (2%)
Query: 12 PSYTPPARTAAPQILAGSL---KAPLWLRAYFQGLLFSLGCGIQRHCGKVLFLGLLAFGA 68
PSY A A QI G KAPLWLRA FQ LLF LGC IQ++CGK L +GLL FGA
Sbjct: 53 PSYCDAA-FALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGA 111
Query: 69 LALGLRMAIIETNLEQLWVEVGSRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGENILT 128
A+GL+ A +ETN+E+LWVEVG RVS+EL+YT++K+GEEA + Q++IQT ++EG N+LT
Sbjct: 112 FAVGLKAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLT 171
Query: 129 PEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLIENGMIERMIEKLFPCVILTP 188
EAL HL +AL AS+V V +Y + W L +CYKSG + E G ++++IE L+PC+I+TP
Sbjct: 172 TEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITP 231
Query: 189 LDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFA-SLEGFRELLDKAQVGQAY 247
LDCFWEGAKLQ G+AYL G+P ++WTN DP + LEEL ++ + E+L+KA+VG Y
Sbjct: 232 LDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGY 291
Query: 248 VGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSHKFMHWQEELLLGGMARDPQ 307
+ RPCL+P D CP +APN +S + ++A L+GGCHG S K+MHWQEEL++GG ++
Sbjct: 292 MDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNST 351
Query: 308 GELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLAQEAL 367
G+L+ A ALQ+ F LM+P+Q+YEHF+G I W+E++A+ +L+AWQR +V++ +++
Sbjct: 352 GKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSV 411
Query: 368 PENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTMLRWDCAQSQGSVGL 427
+N++Q++ +F++TTLDDIL +FS+VS RV GYLLMLAYAC+TMLRWDC++SQG+VGL
Sbjct: 412 AQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGL 471
Query: 428 AGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPG--T 485
AGVLLVAL+VA+GLGLC+L+GI+FNAATTQVLPFLALG+GVDDVFLLAHAF+E
Sbjct: 472 AGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRI 531
Query: 486 PLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLV 545
P ++R GECL+RTG SV LTSI+N+ AF MAAL+PIPALRAFSLQAA+VV F V+L+
Sbjct: 532 PFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLI 591
Query: 546 FPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQILPQELGD-------GTVPVGIAH--- 595
FPAILS+DL RR +RLD+ CCF+SPC ++VIQ+ PQ D P +H
Sbjct: 592 FPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFA 651
Query: 596 ------LTATVQAFTHCEASSQHVVTILPPQAHLVPPP----SDPLGSELFSPGGSTRDL 645
+ +TVQ T + + T P++ + P D L + STRDL
Sbjct: 652 HETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDL 711
Query: 646 LGQEEETRQKAACKSLPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGAT 705
L Q ++ C PC +W L+ FA +AP LL+ AK +V+ LF LLG+SLYG T
Sbjct: 712 LSQFSDS--SLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTT 769
Query: 706 LVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSS 765
V+DGL LTD+VPR T+E+ F++AQ +YFS Y + +VTQ DY + Q L+DLH+ FS+
Sbjct: 770 RVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKA-DYPNIQHLLYDLHRSFSN 828
Query: 766 LKAVLPPPATQAPRTWLHYYRNWLQGIQAAFDQDWASGRITRHSYRNGSEDGALAYKLLI 825
+K V+ Q P+ WLHY+R+WLQG+Q AFD DW +G+I ++Y+NGS+DG LAYKLL+
Sbjct: 829 VKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLV 888
Query: 826 QTGDAQEPLDFSQLTTRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEW 885
QTG +P+D SQLT ++LVD +G+I P FY+ LT WVS+DP+ AASQAN P PEW
Sbjct: 889 QTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEW 948
Query: 886 LHDKYDTTGE-NLRIPPAQPLEFAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHA 944
+HDK D E LRIP A+P+E+AQFPF L GL+ T+DFVEAIE R C+ G+ +
Sbjct: 949 VHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSS 1008
Query: 945 YPSGSPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELF 1004
YP+G PFLFWEQY+GLR LL + ++L CTFLVCA+ LLNPWTAG+IV+VLA+MTVELF
Sbjct: 1009 YPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELF 1068
Query: 1005 GIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSRNLRAAHALEHTFAPVTD 1064
G+MG +GIKLSA+PVVIL+ASVGIGVEFTVHVAL FLT G +N RA ALEH FAPV D
Sbjct: 1069 GMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLD 1128
Query: 1065 GAISTLLGLLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEV 1120
GA+STLLG+LMLAGS FDFIVRYFFA L +LT+LG+L+GLVLLPVLLS GP PEV
Sbjct: 1129 GAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEV 1184
Score = 31.2 bits (69), Expect = 6.2
Identities = 16/35 (45%), Positives = 22/35 (62%), Gaps = 5/35 (14%)
Query: 1147 SSLPQSFARVTT-----SMTVAIHPPPLPGAYIHP 1176
SS+P +TT S+TVA+HPPP+PG +P
Sbjct: 1359 SSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNP 1393
>gi|134254432 patched isoform L' [Homo sapiens]
Length = 1446
Score = 1278 bits (3306), Expect = 0.0
Identities = 634/1114 (56%), Positives = 828/1114 (74%), Gaps = 27/1114 (2%)
Query: 31 KAPLWLRAYFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVG 90
KAPLWLRA FQ LLF LGC IQ++CGK L +GLL FGA A+GL+ A +ETN+E+LWVEVG
Sbjct: 73 KAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVG 132
Query: 91 SRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLY 150
RVS+EL+YT++K+GEEA + Q++IQT ++EG N+LT EAL HL +AL AS+V V +Y
Sbjct: 133 GRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMY 192
Query: 151 GKSWDLNKICYKSGVPLIENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPD 210
+ W L +CYKSG + E G ++++IE L+PC+I+TPLDCFWEGAKLQ G+AYL G+P
Sbjct: 193 NRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPP 252
Query: 211 IQWTNLDPEQLLEELGPFA-SLEGFRELLDKAQVGQAYVGRPCLHPDDLHCPPSAPNHHS 269
++WTN DP + LEEL ++ + E+L+KA+VG Y+ RPCL+P D CP +APN +S
Sbjct: 253 LRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNS 312
Query: 270 RQAPNVAHELSGGCHGFSHKFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPRQLY 329
+ ++A L+GGCHG S K+MHWQEEL++GG ++ G+L+ A ALQ+ F LM+P+Q+Y
Sbjct: 313 TKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMY 372
Query: 330 EHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHA 389
EHF+G I W+E++A+ +L+AWQR +V++ +++ +N++Q++ +F++TTLDDIL +
Sbjct: 373 EHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKS 432
Query: 390 FSEVSAARVVGGYLLMLAYACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGI 449
FS+VS RV GYLLMLAYAC+TMLRWDC++SQG+VGLAGVLLVAL+VA+GLGLC+L+GI
Sbjct: 433 FSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGI 492
Query: 450 TFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPG--TPLQERMGECLQRTGTSVVLTSI 507
+FNAATTQVLPFLALG+GVDDVFLLAHAF+E P ++R GECL+RTG SV LTSI
Sbjct: 493 SFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSI 552
Query: 508 NNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCC 567
+N+ AF MAAL+PIPALRAFSLQAA+VV F V+L+FPAILS+DL RR +RLD+ CC
Sbjct: 553 SNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 612
Query: 568 FSSPCSAQVIQILPQELGD-------GTVPVGIAH---------LTATVQAFTHCEASSQ 611
F+SPC ++VIQ+ PQ D P +H + +TVQ T + +
Sbjct: 613 FTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTH 672
Query: 612 HVVTILPPQAHLVPPP----SDPLGSELFSPGGSTRDLLGQEEETRQKAACKSLPCARWN 667
T P++ + P D L + STRDLL Q ++ C PC +W
Sbjct: 673 VYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDS--SLHCLEPPCTKWT 730
Query: 668 LAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFL 727
L+ FA +AP LL+ AK +V+ LF LLG+SLYG T V+DGL LTD+VPR T+E+ F+
Sbjct: 731 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 790
Query: 728 SAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRN 787
+AQ +YFS Y + +VTQ DY + Q L+DLH+ FS++K V+ Q P+ WLHY+R+
Sbjct: 791 AAQFKYFSFYNMYIVTQKA-DYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRD 849
Query: 788 WLQGIQAAFDQDWASGRITRHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDR 847
WLQG+Q AFD DW +G+I ++Y+NGS+DG LAYKLL+QTG +P+D SQLT ++LVD
Sbjct: 850 WLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDA 909
Query: 848 EGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGE-NLRIPPAQPLE 906
+G+I P FY+ LT WVS+DP+ AASQAN P PEW+HDK D E LRIP A+P+E
Sbjct: 910 DGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIE 969
Query: 907 FAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLL 966
+AQFPF L GL+ T+DFVEAIE R C+ G+ +YP+G PFLFWEQY+GLR LL
Sbjct: 970 YAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLL 1029
Query: 967 AVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASV 1026
+ ++L CTFLVCA+ LLNPWTAG+IV+VLA+MTVELFG+MG +GIKLSA+PVVIL+ASV
Sbjct: 1030 FISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASV 1089
Query: 1027 GIGVEFTVHVALGFLTTQGSRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVR 1086
GIGVEFTVHVAL FLT G +N RA ALEH FAPV DGA+STLLG+LMLAGS FDFIVR
Sbjct: 1090 GIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVR 1149
Query: 1087 YFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEV 1120
YFFA L +LT+LG+L+GLVLLPVLLS GP PEV
Sbjct: 1150 YFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEV 1183
Score = 31.2 bits (69), Expect = 6.2
Identities = 16/35 (45%), Positives = 22/35 (62%), Gaps = 5/35 (14%)
Query: 1147 SSLPQSFARVTT-----SMTVAIHPPPLPGAYIHP 1176
SS+P +TT S+TVA+HPPP+PG +P
Sbjct: 1358 SSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNP 1392
>gi|134254466 patched isoform M [Homo sapiens]
Length = 1381
Score = 1278 bits (3306), Expect = 0.0
Identities = 634/1114 (56%), Positives = 828/1114 (74%), Gaps = 27/1114 (2%)
Query: 31 KAPLWLRAYFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVG 90
KAPLWLRA FQ LLF LGC IQ++CGK L +GLL FGA A+GL+ A +ETN+E+LWVEVG
Sbjct: 8 KAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVG 67
Query: 91 SRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLY 150
RVS+EL+YT++K+GEEA + Q++IQT ++EG N+LT EAL HL +AL AS+V V +Y
Sbjct: 68 GRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMY 127
Query: 151 GKSWDLNKICYKSGVPLIENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPD 210
+ W L +CYKSG + E G ++++IE L+PC+I+TPLDCFWEGAKLQ G+AYL G+P
Sbjct: 128 NRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPP 187
Query: 211 IQWTNLDPEQLLEELGPFA-SLEGFRELLDKAQVGQAYVGRPCLHPDDLHCPPSAPNHHS 269
++WTN DP + LEEL ++ + E+L+KA+VG Y+ RPCL+P D CP +APN +S
Sbjct: 188 LRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNS 247
Query: 270 RQAPNVAHELSGGCHGFSHKFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPRQLY 329
+ ++A L+GGCHG S K+MHWQEEL++GG ++ G+L+ A ALQ+ F LM+P+Q+Y
Sbjct: 248 TKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMY 307
Query: 330 EHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHA 389
EHF+G I W+E++A+ +L+AWQR +V++ +++ +N++Q++ +F++TTLDDIL +
Sbjct: 308 EHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKS 367
Query: 390 FSEVSAARVVGGYLLMLAYACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGI 449
FS+VS RV GYLLMLAYAC+TMLRWDC++SQG+VGLAGVLLVAL+VA+GLGLC+L+GI
Sbjct: 368 FSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGI 427
Query: 450 TFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPG--TPLQERMGECLQRTGTSVVLTSI 507
+FNAATTQVLPFLALG+GVDDVFLLAHAF+E P ++R GECL+RTG SV LTSI
Sbjct: 428 SFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSI 487
Query: 508 NNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCC 567
+N+ AF MAAL+PIPALRAFSLQAA+VV F V+L+FPAILS+DL RR +RLD+ CC
Sbjct: 488 SNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 547
Query: 568 FSSPCSAQVIQILPQELGD-------GTVPVGIAH---------LTATVQAFTHCEASSQ 611
F+SPC ++VIQ+ PQ D P +H + +TVQ T + +
Sbjct: 548 FTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTH 607
Query: 612 HVVTILPPQAHLVPPP----SDPLGSELFSPGGSTRDLLGQEEETRQKAACKSLPCARWN 667
T P++ + P D L + STRDLL Q ++ C PC +W
Sbjct: 608 VYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDS--SLHCLEPPCTKWT 665
Query: 668 LAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFL 727
L+ FA +AP LL+ AK +V+ LF LLG+SLYG T V+DGL LTD+VPR T+E+ F+
Sbjct: 666 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 725
Query: 728 SAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRN 787
+AQ +YFS Y + +VTQ DY + Q L+DLH+ FS++K V+ Q P+ WLHY+R+
Sbjct: 726 AAQFKYFSFYNMYIVTQKA-DYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRD 784
Query: 788 WLQGIQAAFDQDWASGRITRHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDR 847
WLQG+Q AFD DW +G+I ++Y+NGS+DG LAYKLL+QTG +P+D SQLT ++LVD
Sbjct: 785 WLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDA 844
Query: 848 EGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGE-NLRIPPAQPLE 906
+G+I P FY+ LT WVS+DP+ AASQAN P PEW+HDK D E LRIP A+P+E
Sbjct: 845 DGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIE 904
Query: 907 FAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLL 966
+AQFPF L GL+ T+DFVEAIE R C+ G+ +YP+G PFLFWEQY+GLR LL
Sbjct: 905 YAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLL 964
Query: 967 AVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASV 1026
+ ++L CTFLVCA+ LLNPWTAG+IV+VLA+MTVELFG+MG +GIKLSA+PVVIL+ASV
Sbjct: 965 FISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASV 1024
Query: 1027 GIGVEFTVHVALGFLTTQGSRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVR 1086
GIGVEFTVHVAL FLT G +N RA ALEH FAPV DGA+STLLG+LMLAGS FDFIVR
Sbjct: 1025 GIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVR 1084
Query: 1087 YFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEV 1120
YFFA L +LT+LG+L+GLVLLPVLLS GP PEV
Sbjct: 1085 YFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEV 1118
Score = 31.2 bits (69), Expect = 6.2
Identities = 16/35 (45%), Positives = 22/35 (62%), Gaps = 5/35 (14%)
Query: 1147 SSLPQSFARVTT-----SMTVAIHPPPLPGAYIHP 1176
SS+P +TT S+TVA+HPPP+PG +P
Sbjct: 1293 SSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNP 1327
>gi|134254450 patched isoform S [Homo sapiens]
Length = 1296
Score = 1167 bits (3018), Expect = 0.0
Identities = 580/1035 (56%), Positives = 761/1035 (73%), Gaps = 27/1035 (2%)
Query: 110 YTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLIE 169
+ Q++IQT ++EG N+LT EAL HL +AL AS+V V +Y + W L +CYKSG + E
Sbjct: 2 FNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITE 61
Query: 170 NGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFA 229
G ++++IE L+PC+I+TPLDCFWEGAKLQ G+AYL G+P ++WTN DP + LEEL
Sbjct: 62 TGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKIN 121
Query: 230 -SLEGFRELLDKAQVGQAYVGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSH 288
++ + E+L+KA+VG Y+ RPCL+P D CP +APN +S + ++A L+GGCHG S
Sbjct: 122 YQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSR 181
Query: 289 KFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQA 348
K+MHWQEEL++GG ++ G+L+ A ALQ+ F LM+P+Q+YEHF+G I W+E++A
Sbjct: 182 KYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKA 241
Query: 349 STVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAY 408
+ +L+AWQR +V++ +++ +N++Q++ +F++TTLDDIL +FS+VS RV GYLLMLAY
Sbjct: 242 AAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAY 301
Query: 409 ACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGV 468
AC+TMLRWDC++SQG+VGLAGVLLVAL+VA+GLGLC+L+GI+FNAATTQVLPFLALG+GV
Sbjct: 302 ACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGV 361
Query: 469 DDVFLLAHAFTEALPG--TPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRA 526
DDVFLLAHAF+E P ++R GECL+RTG SV LTSI+N+ AF MAAL+PIPALRA
Sbjct: 362 DDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRA 421
Query: 527 FSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQILPQELGD 586
FSLQAA+VV F V+L+FPAILS+DL RR +RLD+ CCF+SPC ++VIQ+ PQ D
Sbjct: 422 FSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTD 481
Query: 587 -------GTVPVGIAH---------LTATVQAFTHCEASSQHVVTILPPQAHLVPPP--- 627
P +H + +TVQ T + + T P++ + P
Sbjct: 482 THDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTV 541
Query: 628 -SDPLGSELFSPGGSTRDLLGQEEETRQKAACKSLPCARWNLAHFARYQFAPLLLQSHAK 686
D L + STRDLL Q ++ C PC +W L+ FA +AP LL+ AK
Sbjct: 542 TQDTLSCQSPESTSSTRDLLSQFSDS--SLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAK 599
Query: 687 AIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQGG 746
+V+ LF LLG+SLYG T V+DGL LTD+VPR T+E+ F++AQ +YFS Y + +VTQ
Sbjct: 600 VVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKA 659
Query: 747 FDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRNWLQGIQAAFDQDWASGRIT 806
DY + Q L+DLH+ FS++K V+ Q P+ WLHY+R+WLQG+Q AFD DW +G+I
Sbjct: 660 -DYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIM 718
Query: 807 RHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDREGLIPPELFYMGLTVWVSS 866
++Y+NGS+DG LAYKLL+QTG +P+D SQLT ++LVD +G+I P FY+ LT WVS+
Sbjct: 719 PNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSN 778
Query: 867 DPLGLAASQANFYPPPPEWLHDKYDTTGE-NLRIPPAQPLEFAQFPFLLRGLQKTADFVE 925
DP+ AASQAN P PEW+HDK D E LRIP A+P+E+AQFPF L GL+ T+DFVE
Sbjct: 779 DPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVE 838
Query: 926 AIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLN 985
AIE R C+ G+ +YP+G PFLFWEQY+GLR LL + ++L CTFLVCA+ LLN
Sbjct: 839 AIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLN 898
Query: 986 PWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQG 1045
PWTAG+IV+VLA+MTVELFG+MG +GIKLSA+PVVIL+ASVGIGVEFTVHVAL FLT G
Sbjct: 899 PWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIG 958
Query: 1046 SRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLV 1105
+N RA ALEH FAPV DGA+STLLG+LMLAGS FDFIVRYFFA L +LT+LG+L+GLV
Sbjct: 959 DKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLV 1018
Query: 1106 LLPVLLSILGPPPEV 1120
LLPVLLS GP PEV
Sbjct: 1019 LLPVLLSFFGPYPEV 1033
Score = 31.2 bits (69), Expect = 6.2
Identities = 16/35 (45%), Positives = 22/35 (62%), Gaps = 5/35 (14%)
Query: 1147 SSLPQSFARVTT-----SMTVAIHPPPLPGAYIHP 1176
SS+P +TT S+TVA+HPPP+PG +P
Sbjct: 1208 SSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNP 1242
>gi|134254435 patched isoform S [Homo sapiens]
Length = 1296
Score = 1167 bits (3018), Expect = 0.0
Identities = 580/1035 (56%), Positives = 761/1035 (73%), Gaps = 27/1035 (2%)
Query: 110 YTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLIE 169
+ Q++IQT ++EG N+LT EAL HL +AL AS+V V +Y + W L +CYKSG + E
Sbjct: 2 FNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITE 61
Query: 170 NGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFA 229
G ++++IE L+PC+I+TPLDCFWEGAKLQ G+AYL G+P ++WTN DP + LEEL
Sbjct: 62 TGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKIN 121
Query: 230 -SLEGFRELLDKAQVGQAYVGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSH 288
++ + E+L+KA+VG Y+ RPCL+P D CP +APN +S + ++A L+GGCHG S
Sbjct: 122 YQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSR 181
Query: 289 KFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQA 348
K+MHWQEEL++GG ++ G+L+ A ALQ+ F LM+P+Q+YEHF+G I W+E++A
Sbjct: 182 KYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKA 241
Query: 349 STVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAY 408
+ +L+AWQR +V++ +++ +N++Q++ +F++TTLDDIL +FS+VS RV GYLLMLAY
Sbjct: 242 AAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAY 301
Query: 409 ACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGV 468
AC+TMLRWDC++SQG+VGLAGVLLVAL+VA+GLGLC+L+GI+FNAATTQVLPFLALG+GV
Sbjct: 302 ACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGV 361
Query: 469 DDVFLLAHAFTEALPG--TPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRA 526
DDVFLLAHAF+E P ++R GECL+RTG SV LTSI+N+ AF MAAL+PIPALRA
Sbjct: 362 DDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRA 421
Query: 527 FSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQILPQELGD 586
FSLQAA+VV F V+L+FPAILS+DL RR +RLD+ CCF+SPC ++VIQ+ PQ D
Sbjct: 422 FSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTD 481
Query: 587 -------GTVPVGIAH---------LTATVQAFTHCEASSQHVVTILPPQAHLVPPP--- 627
P +H + +TVQ T + + T P++ + P
Sbjct: 482 THDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTV 541
Query: 628 -SDPLGSELFSPGGSTRDLLGQEEETRQKAACKSLPCARWNLAHFARYQFAPLLLQSHAK 686
D L + STRDLL Q ++ C PC +W L+ FA +AP LL+ AK
Sbjct: 542 TQDTLSCQSPESTSSTRDLLSQFSDS--SLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAK 599
Query: 687 AIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQGG 746
+V+ LF LLG+SLYG T V+DGL LTD+VPR T+E+ F++AQ +YFS Y + +VTQ
Sbjct: 600 VVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKA 659
Query: 747 FDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRNWLQGIQAAFDQDWASGRIT 806
DY + Q L+DLH+ FS++K V+ Q P+ WLHY+R+WLQG+Q AFD DW +G+I
Sbjct: 660 -DYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIM 718
Query: 807 RHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDREGLIPPELFYMGLTVWVSS 866
++Y+NGS+DG LAYKLL+QTG +P+D SQLT ++LVD +G+I P FY+ LT WVS+
Sbjct: 719 PNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSN 778
Query: 867 DPLGLAASQANFYPPPPEWLHDKYDTTGE-NLRIPPAQPLEFAQFPFLLRGLQKTADFVE 925
DP+ AASQAN P PEW+HDK D E LRIP A+P+E+AQFPF L GL+ T+DFVE
Sbjct: 779 DPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVE 838
Query: 926 AIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLN 985
AIE R C+ G+ +YP+G PFLFWEQY+GLR LL + ++L CTFLVCA+ LLN
Sbjct: 839 AIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLN 898
Query: 986 PWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQG 1045
PWTAG+IV+VLA+MTVELFG+MG +GIKLSA+PVVIL+ASVGIGVEFTVHVAL FLT G
Sbjct: 899 PWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIG 958
Query: 1046 SRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLV 1105
+N RA ALEH FAPV DGA+STLLG+LMLAGS FDFIVRYFFA L +LT+LG+L+GLV
Sbjct: 959 DKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLV 1018
Query: 1106 LLPVLLSILGPPPEV 1120
LLPVLLS GP PEV
Sbjct: 1019 LLPVLLSFFGPYPEV 1033
Score = 31.2 bits (69), Expect = 6.2
Identities = 16/35 (45%), Positives = 22/35 (62%), Gaps = 5/35 (14%)
Query: 1147 SSLPQSFARVTT-----SMTVAIHPPPLPGAYIHP 1176
SS+P +TT S+TVA+HPPP+PG +P
Sbjct: 1208 SSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNP 1242
>gi|134254468 patched isoform S [Homo sapiens]
Length = 1296
Score = 1167 bits (3018), Expect = 0.0
Identities = 580/1035 (56%), Positives = 761/1035 (73%), Gaps = 27/1035 (2%)
Query: 110 YTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLIE 169
+ Q++IQT ++EG N+LT EAL HL +AL AS+V V +Y + W L +CYKSG + E
Sbjct: 2 FNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITE 61
Query: 170 NGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFA 229
G ++++IE L+PC+I+TPLDCFWEGAKLQ G+AYL G+P ++WTN DP + LEEL
Sbjct: 62 TGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKIN 121
Query: 230 -SLEGFRELLDKAQVGQAYVGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSH 288
++ + E+L+KA+VG Y+ RPCL+P D CP +APN +S + ++A L+GGCHG S
Sbjct: 122 YQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSR 181
Query: 289 KFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQA 348
K+MHWQEEL++GG ++ G+L+ A ALQ+ F LM+P+Q+YEHF+G I W+E++A
Sbjct: 182 KYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKA 241
Query: 349 STVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAY 408
+ +L+AWQR +V++ +++ +N++Q++ +F++TTLDDIL +FS+VS RV GYLLMLAY
Sbjct: 242 AAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAY 301
Query: 409 ACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGV 468
AC+TMLRWDC++SQG+VGLAGVLLVAL+VA+GLGLC+L+GI+FNAATTQVLPFLALG+GV
Sbjct: 302 ACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGV 361
Query: 469 DDVFLLAHAFTEALPG--TPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRA 526
DDVFLLAHAF+E P ++R GECL+RTG SV LTSI+N+ AF MAAL+PIPALRA
Sbjct: 362 DDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRA 421
Query: 527 FSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQILPQELGD 586
FSLQAA+VV F V+L+FPAILS+DL RR +RLD+ CCF+SPC ++VIQ+ PQ D
Sbjct: 422 FSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTD 481
Query: 587 -------GTVPVGIAH---------LTATVQAFTHCEASSQHVVTILPPQAHLVPPP--- 627
P +H + +TVQ T + + T P++ + P
Sbjct: 482 THDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTV 541
Query: 628 -SDPLGSELFSPGGSTRDLLGQEEETRQKAACKSLPCARWNLAHFARYQFAPLLLQSHAK 686
D L + STRDLL Q ++ C PC +W L+ FA +AP LL+ AK
Sbjct: 542 TQDTLSCQSPESTSSTRDLLSQFSDS--SLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAK 599
Query: 687 AIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQGG 746
+V+ LF LLG+SLYG T V+DGL LTD+VPR T+E+ F++AQ +YFS Y + +VTQ
Sbjct: 600 VVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKA 659
Query: 747 FDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRNWLQGIQAAFDQDWASGRIT 806
DY + Q L+DLH+ FS++K V+ Q P+ WLHY+R+WLQG+Q AFD DW +G+I
Sbjct: 660 -DYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIM 718
Query: 807 RHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDREGLIPPELFYMGLTVWVSS 866
++Y+NGS+DG LAYKLL+QTG +P+D SQLT ++LVD +G+I P FY+ LT WVS+
Sbjct: 719 PNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSN 778
Query: 867 DPLGLAASQANFYPPPPEWLHDKYDTTGE-NLRIPPAQPLEFAQFPFLLRGLQKTADFVE 925
DP+ AASQAN P PEW+HDK D E LRIP A+P+E+AQFPF L GL+ T+DFVE
Sbjct: 779 DPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVE 838
Query: 926 AIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLN 985
AIE R C+ G+ +YP+G PFLFWEQY+GLR LL + ++L CTFLVCA+ LLN
Sbjct: 839 AIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLN 898
Query: 986 PWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQG 1045
PWTAG+IV+VLA+MTVELFG+MG +GIKLSA+PVVIL+ASVGIGVEFTVHVAL FLT G
Sbjct: 899 PWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIG 958
Query: 1046 SRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLV 1105
+N RA ALEH FAPV DGA+STLLG+LMLAGS FDFIVRYFFA L +LT+LG+L+GLV
Sbjct: 959 DKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLV 1018
Query: 1106 LLPVLLSILGPPPEV 1120
LLPVLLS GP PEV
Sbjct: 1019 LLPVLLSFFGPYPEV 1033
Score = 31.2 bits (69), Expect = 6.2
Identities = 16/35 (45%), Positives = 22/35 (62%), Gaps = 5/35 (14%)
Query: 1147 SSLPQSFARVTT-----SMTVAIHPPPLPGAYIHP 1176
SS+P +TT S+TVA+HPPP+PG +P
Sbjct: 1208 SSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNP 1242
>gi|134254452 patched isoform S [Homo sapiens]
Length = 1296
Score = 1167 bits (3018), Expect = 0.0
Identities = 580/1035 (56%), Positives = 761/1035 (73%), Gaps = 27/1035 (2%)
Query: 110 YTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLIE 169
+ Q++IQT ++EG N+LT EAL HL +AL AS+V V +Y + W L +CYKSG + E
Sbjct: 2 FNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITE 61
Query: 170 NGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFA 229
G ++++IE L+PC+I+TPLDCFWEGAKLQ G+AYL G+P ++WTN DP + LEEL
Sbjct: 62 TGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKIN 121
Query: 230 -SLEGFRELLDKAQVGQAYVGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSH 288
++ + E+L+KA+VG Y+ RPCL+P D CP +APN +S + ++A L+GGCHG S
Sbjct: 122 YQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSR 181
Query: 289 KFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQA 348
K+MHWQEEL++GG ++ G+L+ A ALQ+ F LM+P+Q+YEHF+G I W+E++A
Sbjct: 182 KYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKA 241
Query: 349 STVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAY 408
+ +L+AWQR +V++ +++ +N++Q++ +F++TTLDDIL +FS+VS RV GYLLMLAY
Sbjct: 242 AAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAY 301
Query: 409 ACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGV 468
AC+TMLRWDC++SQG+VGLAGVLLVAL+VA+GLGLC+L+GI+FNAATTQVLPFLALG+GV
Sbjct: 302 ACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGV 361
Query: 469 DDVFLLAHAFTEALPG--TPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRA 526
DDVFLLAHAF+E P ++R GECL+RTG SV LTSI+N+ AF MAAL+PIPALRA
Sbjct: 362 DDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRA 421
Query: 527 FSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQILPQELGD 586
FSLQAA+VV F V+L+FPAILS+DL RR +RLD+ CCF+SPC ++VIQ+ PQ D
Sbjct: 422 FSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTD 481
Query: 587 -------GTVPVGIAH---------LTATVQAFTHCEASSQHVVTILPPQAHLVPPP--- 627
P +H + +TVQ T + + T P++ + P
Sbjct: 482 THDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTV 541
Query: 628 -SDPLGSELFSPGGSTRDLLGQEEETRQKAACKSLPCARWNLAHFARYQFAPLLLQSHAK 686
D L + STRDLL Q ++ C PC +W L+ FA +AP LL+ AK
Sbjct: 542 TQDTLSCQSPESTSSTRDLLSQFSDS--SLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAK 599
Query: 687 AIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQGG 746
+V+ LF LLG+SLYG T V+DGL LTD+VPR T+E+ F++AQ +YFS Y + +VTQ
Sbjct: 600 VVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKA 659
Query: 747 FDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRNWLQGIQAAFDQDWASGRIT 806
DY + Q L+DLH+ FS++K V+ Q P+ WLHY+R+WLQG+Q AFD DW +G+I
Sbjct: 660 -DYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIM 718
Query: 807 RHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDREGLIPPELFYMGLTVWVSS 866
++Y+NGS+DG LAYKLL+QTG +P+D SQLT ++LVD +G+I P FY+ LT WVS+
Sbjct: 719 PNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSN 778
Query: 867 DPLGLAASQANFYPPPPEWLHDKYDTTGE-NLRIPPAQPLEFAQFPFLLRGLQKTADFVE 925
DP+ AASQAN P PEW+HDK D E LRIP A+P+E+AQFPF L GL+ T+DFVE
Sbjct: 779 DPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVE 838
Query: 926 AIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLN 985
AIE R C+ G+ +YP+G PFLFWEQY+GLR LL + ++L CTFLVCA+ LLN
Sbjct: 839 AIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLN 898
Query: 986 PWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQG 1045
PWTAG+IV+VLA+MTVELFG+MG +GIKLSA+PVVIL+ASVGIGVEFTVHVAL FLT G
Sbjct: 899 PWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIG 958
Query: 1046 SRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLV 1105
+N RA ALEH FAPV DGA+STLLG+LMLAGS FDFIVRYFFA L +LT+LG+L+GLV
Sbjct: 959 DKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLV 1018
Query: 1106 LLPVLLSILGPPPEV 1120
LLPVLLS GP PEV
Sbjct: 1019 LLPVLLSFFGPYPEV 1033
Score = 31.2 bits (69), Expect = 6.2
Identities = 16/35 (45%), Positives = 22/35 (62%), Gaps = 5/35 (14%)
Query: 1147 SSLPQSFARVTT-----SMTVAIHPPPLPGAYIHP 1176
SS+P +TT S+TVA+HPPP+PG +P
Sbjct: 1208 SSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNP 1242
>gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens]
Length = 1278
Score = 120 bits (302), Expect = 6e-27
Identities = 69/222 (31%), Positives = 119/222 (53%), Gaps = 9/222 (4%)
Query: 353 QAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVT 412
QAW++ F+ + +N + I + +++D L+ S+ VV Y +M Y +
Sbjct: 581 QAWEKEFINFVKNY--KNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLA 638
Query: 413 M-----LRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIG 467
+ R S+ S+G+AG+L+V +VA LG+ + +G+ +V+PFL L +G
Sbjct: 639 LGHIKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVG 698
Query: 468 VDDVFLLAHAFT--EALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALR 525
VD++F+L A+ E L G L +++G L S+ L+S + AF + AL +PA+
Sbjct: 699 VDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVH 758
Query: 526 AFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCC 567
FSL A + V F+ + F ++L LD++R+ RLD+ CC
Sbjct: 759 TFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCC 800
Score = 111 bits (277), Expect = 5e-24
Identities = 72/209 (34%), Positives = 113/209 (54%), Gaps = 9/209 (4%)
Query: 917 LQKTADFVEAIEGARAACAEAGQ------AGVHAYPSGSPFLFWEQYLGLRRCFLLAVCI 970
LQ +ADF++A++ AR + + + +P ++F+EQYL + + + +
Sbjct: 1045 LQTSADFIDALKKARLIASNVTETMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGV 1104
Query: 971 LLVCTFLVCALLL-LNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIG 1029
L FLV +LL W+A ++ +AM+ V +FG+M GI L+A+ +V LV S GI
Sbjct: 1105 SLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGIS 1164
Query: 1030 VEFTVHVALGF-LTTQGSRNLRAAHALEHTFAPVTDGAISTLL-GLLMLAGSHFDFIVRY 1087
VEF H+ F ++ +GSR RA AL H + V G T G+++LA + +
Sbjct: 1165 VEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIF 1224
Query: 1088 FFAALTVLTLLGLLHGLVLLPVLLSILGP 1116
+F + LLG HGL+ LPVLLS +GP
Sbjct: 1225 YFRMYLAMVLLGATHGLIFLPVLLSYIGP 1253
>gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo
sapiens]
Length = 1332
Score = 110 bits (275), Expect = 8e-24
Identities = 84/275 (30%), Positives = 128/275 (46%), Gaps = 20/275 (7%)
Query: 297 LLLGGMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQ 356
L +GG E AEAL TF L + GD + EE ++A+Q
Sbjct: 554 LAIGGYKGKDYSE---AEALIMTF------SLNNYPAGDPRLAQAKLWEEAFLEEMRAFQ 604
Query: 357 RRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTMLRW 416
RR + Q S + +T D + A S + L ++ A + W
Sbjct: 605 RRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVI-------FLYISLALGSYSSW 657
Query: 417 D--CAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFL- 473
S+ ++GL GV +V AV + +G + LGI + QV+PFL L +G D++F+
Sbjct: 658 SRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIF 717
Query: 474 -LAHAFTEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAA 532
L + PG P + +G L R S++L S++ F + AL P+PA+R F+L +
Sbjct: 718 VLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSG 777
Query: 533 IVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCC 567
+ V F+ M F A+LSLD +R+ RLDV CC
Sbjct: 778 LAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCC 812
Score = 99.4 bits (246), Expect = 2e-20
Identities = 76/215 (35%), Positives = 116/215 (53%), Gaps = 18/215 (8%)
Query: 917 LQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPF----------LFWEQYLGL--RRCF 964
L+ + D+ EA+ AR A A + P P +F+EQYL + F
Sbjct: 1056 LKNSQDYTEALRAARELAANI-TADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLF 1114
Query: 965 LLAVCILLVCTFLVCALLLLNPWTAGLI-VLVLAMMTVELFGIMGFLGIKLSAIPVVILV 1023
+L++C LV TF V LLL +GL+ +L + M+ V+ G M GI +A+ ++ LV
Sbjct: 1115 MLSLC--LVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLV 1172
Query: 1024 ASVGIGVEFTVHVALGF-LTTQGSRNLRAAHALEHTFAPVTDG-AISTLLGLLMLAGSHF 1081
++VG+ VEF H+ F ++T+ + RA A + V G A++ L G+L+L +
Sbjct: 1173 SAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKA 1232
Query: 1082 DFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGP 1116
I +FF ++TLLGLLHGLV LPV+LS +GP
Sbjct: 1233 QLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGP 1267
Score = 35.0 bits (79), Expect = 0.43
Identities = 34/128 (26%), Positives = 61/128 (47%), Gaps = 4/128 (3%)
Query: 426 GLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGT 485
GL +L + + + +G AL GI++NA + L A+G+ V+ V + +F + T
Sbjct: 1138 GLLNLLSIVMILVDTVGFMALWGISYNAVSLINL-VSAVGMSVEFVSHITRSFAISTKPT 1196
Query: 486 PLQERMGECLQRTGTSVVL-TSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVML 544
L ER E G++V ++ N+ L+ L ++ F + +++ + L
Sbjct: 1197 WL-ERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGL 1255
Query: 545 VF-PAILS 551
VF P ILS
Sbjct: 1256 VFLPVILS 1263
>gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo
sapiens]
Length = 1359
Score = 110 bits (275), Expect = 8e-24
Identities = 84/275 (30%), Positives = 128/275 (46%), Gaps = 20/275 (7%)
Query: 297 LLLGGMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQ 356
L +GG E AEAL TF L + GD + EE ++A+Q
Sbjct: 554 LAIGGYKGKDYSE---AEALIMTF------SLNNYPAGDPRLAQAKLWEEAFLEEMRAFQ 604
Query: 357 RRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTMLRW 416
RR + Q S + +T D + A S + L ++ A + W
Sbjct: 605 RRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVI-------FLYISLALGSYSSW 657
Query: 417 D--CAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFL- 473
S+ ++GL GV +V AV + +G + LGI + QV+PFL L +G D++F+
Sbjct: 658 SRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIF 717
Query: 474 -LAHAFTEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAA 532
L + PG P + +G L R S++L S++ F + AL P+PA+R F+L +
Sbjct: 718 VLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSG 777
Query: 533 IVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCC 567
+ V F+ M F A+LSLD +R+ RLDV CC
Sbjct: 778 LAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCC 812
Score = 99.4 bits (246), Expect = 2e-20
Identities = 76/215 (35%), Positives = 116/215 (53%), Gaps = 18/215 (8%)
Query: 917 LQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPF----------LFWEQYLGL--RRCF 964
L+ + D+ EA+ AR A A + P P +F+EQYL + F
Sbjct: 1083 LKNSQDYTEALRAARELAANI-TADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLF 1141
Query: 965 LLAVCILLVCTFLVCALLLLNPWTAGLI-VLVLAMMTVELFGIMGFLGIKLSAIPVVILV 1023
+L++C LV TF V LLL +GL+ +L + M+ V+ G M GI +A+ ++ LV
Sbjct: 1142 MLSLC--LVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLV 1199
Query: 1024 ASVGIGVEFTVHVALGF-LTTQGSRNLRAAHALEHTFAPVTDG-AISTLLGLLMLAGSHF 1081
++VG+ VEF H+ F ++T+ + RA A + V G A++ L G+L+L +
Sbjct: 1200 SAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKA 1259
Query: 1082 DFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGP 1116
I +FF ++TLLGLLHGLV LPV+LS +GP
Sbjct: 1260 QLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGP 1294
Score = 35.0 bits (79), Expect = 0.43
Identities = 34/128 (26%), Positives = 61/128 (47%), Gaps = 4/128 (3%)
Query: 426 GLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGT 485
GL +L + + + +G AL GI++NA + L A+G+ V+ V + +F + T
Sbjct: 1165 GLLNLLSIVMILVDTVGFMALWGISYNAVSLINL-VSAVGMSVEFVSHITRSFAISTKPT 1223
Query: 486 PLQERMGECLQRTGTSVVL-TSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVML 544
L ER E G++V ++ N+ L+ L ++ F + +++ + L
Sbjct: 1224 WL-ERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGL 1282
Query: 545 VF-PAILS 551
VF P ILS
Sbjct: 1283 VFLPVILS 1290
>gi|194018513 patched domain containing 3 [Homo sapiens]
Length = 767
Score = 79.3 bits (194), Expect = 2e-14
Identities = 43/155 (27%), Positives = 80/155 (51%), Gaps = 1/155 (0%)
Query: 402 YLLMLAYACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPF 461
Y+L++ +A + R+DC +++ V GV+ LAV SG GL +G+ F PF
Sbjct: 391 YILIILFAVTSCFRFDCIRNKMCVAAFGVISAFLAVVSGFGLLLHIGVPFVIIVANS-PF 449
Query: 462 LALGIGVDDVFLLAHAFTEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPI 521
L LG+GVDD+F++ A+ + ++ERM + S+ +T+I N+ A +
Sbjct: 450 LILGVGVDDMFIMISAWHKTNLADDIRERMSNVYSKAAVSITITTITNILALYTGIMSSF 509
Query: 522 PALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRR 556
+++ F + + + + + F A ++LD +R
Sbjct: 510 RSVQCFCIYTGMTLLFCYFYNITCFGAFMALDGKR 544
Score = 36.2 bits (82), Expect = 0.19
Identities = 30/126 (23%), Positives = 52/126 (41%), Gaps = 10/126 (7%)
Query: 671 FARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQ 730
F R F P L +S +K V+ ++ + S+YG VQ+GL L ++ + + + +
Sbjct: 587 FFRDYFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNVE 646
Query: 731 LRYFSLY--EVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPA---TQAPRTWLHYY 785
YFS Y V ++ DY D+ Q+ + + WL Y
Sbjct: 647 ENYFSDYGPRVMVIVTKKVDYWDK-----DVRQKLENCTKIFEKNVYVDKNLTEFWLDAY 701
Query: 786 RNWLQG 791
+L+G
Sbjct: 702 VQYLKG 707
>gi|66932902 SREBF chaperone protein [Homo sapiens]
Length = 1279
Score = 72.8 bits (177), Expect = 2e-12
Identities = 43/173 (24%), Positives = 84/173 (48%), Gaps = 3/173 (1%)
Query: 387 LHAFSEVSAARV---VGGYLLMLAYACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGL 443
+H E+ A + V Y+++ AY + + D +S+ + LA V+ V ++ +GL
Sbjct: 274 VHFKEEIGVAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGL 333
Query: 444 CALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGTPLQERMGECLQRTGTSVV 503
C L G+T ++ P+L + IG+++V +L + ++ R+ + L S++
Sbjct: 334 CTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIM 393
Query: 504 LTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRR 556
+ L+ +PA++ F L A + + F ML F +LS+D+RR
Sbjct: 394 KNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRR 446
>gi|149274653 patched domain containing 2 [Homo sapiens]
Length = 1392
Score = 67.8 bits (164), Expect = 6e-11
Identities = 60/244 (24%), Positives = 104/244 (42%), Gaps = 20/244 (8%)
Query: 311 LRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLAQEALPEN 370
L++ L+S L +P +Y + D W E++A + FV L +
Sbjct: 390 LKSSLLRSEILFGAPLP-------NYYSVDDRWEEQRAKF------QSFVVTYVAMLAKQ 436
Query: 371 ASQQIHA-FSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTMLRWDCAQSQGSVGLAG 429
++ ++ + T L D EV L ++ +C+ L + + G
Sbjct: 437 STSKVQVLYGGTDLFDY-----EVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFG 491
Query: 430 VLLVALAVASGLGLC-ALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGTPLQ 488
+ + L+ L L + GI + V F+ +GIGVDDVF+ + + +A Q
Sbjct: 492 IASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQ 551
Query: 489 ERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPA 548
RM +Q G + TS+ AA+ IPA+ F L +++V C ++AV++ PA
Sbjct: 552 LRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPA 611
Query: 549 ILSL 552
L L
Sbjct: 612 ALGL 615
Score = 43.9 bits (102), Expect = 0.001
Identities = 42/166 (25%), Positives = 73/166 (43%), Gaps = 25/166 (15%)
Query: 966 LAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVAS 1025
L +C+ V F LLLL P ++ +V ++T IM + G ++ A+ + L
Sbjct: 1191 LLICVAAVAVFTTHILLLL-PVLLSILGIVCLVVT-----IMYWSGWEMGAVEAISLSIL 1244
Query: 1026 VGIGVEFTVHVALGFL------------TTQGSRNLRAAHALEHTFAPVTDGAISTLLGL 1073
VG V++ VH+ G+L + R R A+ H + A++T++
Sbjct: 1245 VGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVIAT 1304
Query: 1074 LMLAGSHFDFIVRYF--FAALTVL-TLLGLLHGLVLLPVLLSILGP 1116
+ L F I+ F F + L T + +L+ L + LL I+ P
Sbjct: 1305 VPL----FFCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAP 1346
>gi|148277106 hypothetical protein LOC442213 [Homo sapiens]
Length = 829
Score = 67.4 bits (163), Expect = 8e-11
Identities = 50/221 (22%), Positives = 99/221 (44%), Gaps = 11/221 (4%)
Query: 353 QAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVT 412
+ W+ F +L ++ E+ Q+++ +S +L H S ++ ++V+ +L+L A ++
Sbjct: 175 EKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLS 234
Query: 413 MLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVF 472
DC +S+ +GL GVL V +++ + G+ + +N +T +PF A+G G VF
Sbjct: 235 SSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYN-STLLGIPFFAMGHGTKGVF 293
Query: 473 LLAHAFTEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAA--LVPIPALRAFSLQ 530
L + P ++R+ + + +TS F M A I A++ F
Sbjct: 294 ELLSGWRRTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQN 353
Query: 531 AAIVVGCTFVAVMLVFPAIL----SLDLRRRHCQRLDVLCC 567
+ + + + F + L L+ R H + CC
Sbjct: 354 MCVSILLNYFYIFSFFGSCLVFAGQLEQNRYH----SIFCC 390
Score = 43.5 bits (101), Expect = 0.001
Identities = 44/175 (25%), Positives = 80/175 (45%), Gaps = 18/175 (10%)
Query: 951 FLFWEQY-LGLRRCFLLA---VCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVEL--F 1004
F+F + Y L + L+A V ++L+ TF + L N W L+L++ ++EL
Sbjct: 630 FVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFW------LILSVTSIELGVL 683
Query: 1005 GIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGF-LTTQGSRNLRAAHALEHTFAPVT 1063
G+M + + I ++ L+ ++ ++ + F L T+ +R +L+ +
Sbjct: 684 GLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAIL 743
Query: 1064 DGAISTLLGL--LMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGP 1116
S L+GL L+ S+ F + F L + LLH V+LPV L+ P
Sbjct: 744 QNVTSFLIGLVPLLFVPSNLTFTL---FKCLLLTGGCTLLHCFVILPVFLTFFPP 795
Score = 32.3 bits (72), Expect = 2.8
Identities = 15/70 (21%), Positives = 31/70 (44%)
Query: 668 LAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFL 727
+ HF R + + + K V++L+ S G + DG + +++ + ++
Sbjct: 429 IQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYA 488
Query: 728 SAQLRYFSLY 737
Q +YFS Y
Sbjct: 489 MVQQKYFSNY 498
>gi|148271104 patched domain containing 1 [Homo sapiens]
Length = 888
Score = 63.9 bits (154), Expect = 9e-10
Identities = 56/254 (22%), Positives = 110/254 (43%), Gaps = 22/254 (8%)
Query: 299 LGGMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQRR 358
LGG+ + + AEA+Q T+ L S L + V + W+
Sbjct: 192 LGGVTVHSKDRVKSAEAIQLTYYLQSINSLND-------------------MVAERWESS 232
Query: 359 FVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTMLRWDC 418
F + N+ +++ ++S++L + S VS +V +L++ A + DC
Sbjct: 233 FCDTVRLFQKSNSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDC 292
Query: 419 AQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAF 478
+S+ +GL G++ ++LA + G+ L G +N +T +PF+ LG G+ F + ++
Sbjct: 293 VRSKPWLGLLGLVTISLATLTAAGIINLTGGKYN-STFLGVPFVMLGHGLYGTFEMLSSW 351
Query: 479 TEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAA--LVPIPALRAFSLQAAIVVG 536
+ ++ER + S LT+ + F + A I A R F + I +
Sbjct: 352 RKTREDQHVKERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIF 411
Query: 537 CTFVAVMLVFPAIL 550
++ V+ + + L
Sbjct: 412 FNYLYVLSFYGSSL 425
Score = 45.1 bits (105), Expect = 4e-04
Identities = 48/192 (25%), Positives = 90/192 (46%), Gaps = 27/192 (14%)
Query: 951 FLFWEQYLG-----LRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFG 1005
F++ ++Y L + A+ +L FLV A L+N W + L +++VE FG
Sbjct: 686 FVYMDRYASSLGAPLHNSCISALFLLFFSAFLV-ADSLINVW------ITLTVVSVE-FG 737
Query: 1006 IMGFLG---IKLSAIPVVILVASVGIGVEFTVHVALGFLTT-----QGSRNLRAAHALEH 1057
++GF+ ++L I V+ L+ G+ +T+ L+T +R +ALE
Sbjct: 738 VIGFMTLWKVELDCISVLCLI----YGINYTIDNCAPMLSTFVLGKDFTRTKWVKNALEV 793
Query: 1058 TFAPVTDGAISTLLGLLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPP 1117
+ + ++GL+ LA + + F L ++ + H +LPV+L+ L PP
Sbjct: 794 HGVAILQSYLCYIVGLIPLAAVPSN-LTCTLFRCLFLIAFVTFFHCFAILPVILTFL-PP 851
Query: 1118 PEVIQMYKESPE 1129
+ + K++PE
Sbjct: 852 SKKKRKEKKNPE 863
>gi|25952134 dispatched A [Homo sapiens]
Length = 1524
Score = 45.8 bits (107), Expect = 2e-04
Identities = 31/113 (27%), Positives = 49/113 (43%), Gaps = 7/113 (6%)
Query: 462 LALGIGVDDVFLLAHAFTEAL---PGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAAL 518
+ +GIG DD F+L + P E + LQ S+ +TS AAF +
Sbjct: 565 ILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYV 624
Query: 519 VPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSP 571
I A+R F + A + +V ++ PA++ L R L++ CF P
Sbjct: 625 SNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHER----YLLNIFTCFKKP 673
Score = 32.3 bits (72), Expect = 2.8
Identities = 22/104 (21%), Positives = 48/104 (46%), Gaps = 4/104 (3%)
Query: 980 ALLLLNPWTAGLIVLVLAMMTVELFGIMG---FLGIKLSAIPVVILVASVGIGVEFTVHV 1036
+++LL W + + + + +F +G LG +L+ + V + +VG+ V+F VH
Sbjct: 997 SVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHY 1056
Query: 1037 ALGF-LTTQGSRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGS 1079
+ + L R + +L + + A++T + M+ S
Sbjct: 1057 GVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPS 1100
>gi|85815829 SH3-domain binding protein 1 [Homo sapiens]
Length = 701
Score = 40.4 bits (93), Expect = 0.010
Identities = 29/89 (32%), Positives = 38/89 (42%), Gaps = 10/89 (11%)
Query: 1116 PPPEVIQMYKESPEILSPPAPQGGGLRWGASSSLPQSFAR--VTTSMTVAIHPPPLPGAY 1173
PPP+V P +PP P G G S PQ+ R V +S+ PPPLP
Sbjct: 576 PPPQVSGSRSSPP---APPLPPGSG-----SPGTPQALPRRLVGSSLRAPTVPPPLPPTP 627
Query: 1174 IHPAPDEPPWSPAATSSGNLSSRGPGPAT 1202
PA + SPA+ S + P P +
Sbjct: 628 PQPARRQSRRSPASPSPASPGPASPSPVS 656
>gi|25121980 dispatched B [Homo sapiens]
Length = 1401
Score = 39.7 bits (91), Expect = 0.017
Identities = 36/112 (32%), Positives = 54/112 (48%), Gaps = 5/112 (4%)
Query: 970 ILLVCTFLVCALLLLNPWTAGLIVLVLAMM--TVEL-FGIMGFLGIKLSAIPVVILVASV 1026
+L + L A LLL W L + +A + TV L G++ L +L+ + L ASV
Sbjct: 967 VLGLALALAFATLLLGTWNVPLSLFSVAAVAGTVLLTVGLLVLLEWQLNTAEALFLSASV 1026
Query: 1027 GIGVEFTVHVALGF-LTTQGSRNLRAAHALEHTFAPVTDGAISTL-LGLLML 1076
G+ V+FTV+ + + L R R A +L T GA + G+LML
Sbjct: 1027 GLSVDFTVNYCISYHLCPHPDRLSRVAFSLRQTSCATAVGAAALFAAGVLML 1078
Score = 34.3 bits (77), Expect = 0.73
Identities = 23/82 (28%), Positives = 38/82 (46%), Gaps = 2/82 (2%)
Query: 482 LPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSL--QAAIVVGCTF 539
LP L +R+G + G ++++ + AAF + L +PA+R +L A++V
Sbjct: 573 LPSGGLAQRVGRTMHHFGYLLLVSGLTTSAAFYASYLSRLPAVRCLALFMGTAVLVHLAL 632
Query: 540 VAVMLVFPAILSLDLRRRHCQR 561
V L A+L R C R
Sbjct: 633 TLVWLPASAVLHERYLARGCAR 654
>gi|21536320 heterogeneous nuclear ribonucleoprotein U-like 1 isoform
d [Homo sapiens]
Length = 756
Score = 38.9 bits (89), Expect = 0.030
Identities = 29/98 (29%), Positives = 40/98 (40%), Gaps = 12/98 (12%)
Query: 1116 PPPEVIQMYKESPEILSPPAPQGGGLRWGASSSLPQSFARVTTSMTVAIHPPPLP----- 1170
PPP+ P SP G + +S++P S A +T TV+ + PP P
Sbjct: 602 PPPQPPPQQPPPPPSYSPARNPPGASTYNKNSNIPGSSANTSTP-TVSSYSPPQPSYSQP 660
Query: 1171 ----GAYI--HPAPDEPPWSPAATSSGNLSSRGPGPAT 1202
G Y + AP PP P A + G+ P P T
Sbjct: 661 PYNQGGYSQGYTAPPPPPPPPPAYNYGSYGGYNPAPYT 698
>gi|21536326 heterogeneous nuclear ribonucleoprotein U-like 1 isoform
a [Homo sapiens]
Length = 856
Score = 38.9 bits (89), Expect = 0.030
Identities = 29/98 (29%), Positives = 40/98 (40%), Gaps = 12/98 (12%)
Query: 1116 PPPEVIQMYKESPEILSPPAPQGGGLRWGASSSLPQSFARVTTSMTVAIHPPPLP----- 1170
PPP+ P SP G + +S++P S A +T TV+ + PP P
Sbjct: 702 PPPQPPPQQPPPPPSYSPARNPPGASTYNKNSNIPGSSANTSTP-TVSSYSPPQPSYSQP 760
Query: 1171 ----GAYI--HPAPDEPPWSPAATSSGNLSSRGPGPAT 1202
G Y + AP PP P A + G+ P P T
Sbjct: 761 PYNQGGYSQGYTAPPPPPPPPPAYNYGSYGGYNPAPYT 798
>gi|39812378 RAN binding protein 9 [Homo sapiens]
Length = 729
Score = 37.7 bits (86), Expect = 0.066
Identities = 28/99 (28%), Positives = 38/99 (38%), Gaps = 9/99 (9%)
Query: 1114 LGPPPEVIQMYKESPEILSPPAPQGGGLRWGASSSLPQSFARVTTSMTVAIHPPPL-PGA 1172
L PPP + +PPA G G+ + + +HPPP P A
Sbjct: 19 LSPPPPAALAPVSGVVLPAPPAVSAGSSPAGSPGGGAGGEGLGAAAAALLLHPPPPPPPA 78
Query: 1173 YIHPAPDEPPWSPAATSSGNLS--------SRGPGPATG 1203
P P PP P A+++ S + GPGPA G
Sbjct: 79 TAAPPPPPPPPPPPASAAAPASGPPAPPGLAAGPGPAGG 117
>gi|14270490 protocadherin gamma subfamily B, 1 isoform 2 precursor
[Homo sapiens]
Length = 810
Score = 37.4 bits (85), Expect = 0.087
Identities = 30/109 (27%), Positives = 46/109 (42%), Gaps = 1/109 (0%)
Query: 520 PIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQI 579
P P+ LQ +VV ++V+ + IL++ LR R LD CF + ++
Sbjct: 675 PEPSDPQTELQFYLVVALALISVLFLLAVILAIALRLRRSSSLDTEGCFQTGLCSKSGPG 734
Query: 580 LPQELGDGTVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLVPPPS 628
+P +GT+P A+ A T S + PPQ L PS
Sbjct: 735 VPPNHSEGTLPYSYNLCIASHSAKTEFN-SLNLTPEMAPPQDLLCDDPS 782
>gi|11128037 protocadherin gamma subfamily B, 1 isoform 1 precursor
[Homo sapiens]
Length = 927
Score = 37.4 bits (85), Expect = 0.087
Identities = 30/109 (27%), Positives = 46/109 (42%), Gaps = 1/109 (0%)
Query: 520 PIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQI 579
P P+ LQ +VV ++V+ + IL++ LR R LD CF + ++
Sbjct: 675 PEPSDPQTELQFYLVVALALISVLFLLAVILAIALRLRRSSSLDTEGCFQTGLCSKSGPG 734
Query: 580 LPQELGDGTVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLVPPPS 628
+P +GT+P A+ A T S + PPQ L PS
Sbjct: 735 VPPNHSEGTLPYSYNLCIASHSAKTEFN-SLNLTPEMAPPQDLLCDDPS 782
>gi|192807286 zinc finger and BTB domain containing 4 [Homo sapiens]
Length = 1013
Score = 36.6 bits (83), Expect = 0.15
Identities = 25/90 (27%), Positives = 37/90 (41%), Gaps = 5/90 (5%)
Query: 1115 GPPPEVIQMYKESPEILSPPAPQGGGLRWGASSSLPQSFARVTTSMTVAIHPPPLPGAYI 1174
GPPP VI +P ++ GG G S + ++ + +T P P
Sbjct: 466 GPPPSVITFAHPAPSVIVHGGSSSGG---GGSGTASTGGSQAASVITYTAPPRPPKKREY 522
Query: 1175 HPAPDEPPWSPA--ATSSGNLSSRGPGPAT 1202
P P EP +P AT+ ++ GP AT
Sbjct: 523 PPPPPEPAATPTSPATAVSPATAAGPAMAT 552
>gi|192807284 zinc finger and BTB domain containing 4 [Homo sapiens]
Length = 1013
Score = 36.6 bits (83), Expect = 0.15
Identities = 25/90 (27%), Positives = 37/90 (41%), Gaps = 5/90 (5%)
Query: 1115 GPPPEVIQMYKESPEILSPPAPQGGGLRWGASSSLPQSFARVTTSMTVAIHPPPLPGAYI 1174
GPPP VI +P ++ GG G S + ++ + +T P P
Sbjct: 466 GPPPSVITFAHPAPSVIVHGGSSSGG---GGSGTASTGGSQAASVITYTAPPRPPKKREY 522
Query: 1175 HPAPDEPPWSPA--ATSSGNLSSRGPGPAT 1202
P P EP +P AT+ ++ GP AT
Sbjct: 523 PPPPPEPAATPTSPATAVSPATAAGPAMAT 552
>gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]
Length = 502
Score = 36.2 bits (82), Expect = 0.19
Identities = 34/95 (35%), Positives = 37/95 (38%), Gaps = 24/95 (25%)
Query: 1106 LLPVLLSILGPPPEVIQMYKESPEILSPPAPQGGGLRWGASSSLPQSFARVTTSMTVAIH 1165
L PV L I PPP +P PP P GG P T + +
Sbjct: 342 LPPVPLGIAPPPP--------TPR--GPPPPGRGG---------PPPPPPPATGRSGPLP 382
Query: 1166 PPPLPGAYIHPAPDEPPWSPAATSSGNLSSRGPGP 1200
PPP PGA P P PP P SSGN GP P
Sbjct: 383 PPP-PGAGGPPMPPPPPPPPPPPSSGN----GPAP 412
>gi|14270505 protocadherin gamma subfamily B, 5 isoform 2 precursor
[Homo sapiens]
Length = 818
Score = 35.8 bits (81), Expect = 0.25
Identities = 23/91 (25%), Positives = 37/91 (40%), Gaps = 4/91 (4%)
Query: 520 PIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQI 579
P+P+ LQ +VV ++V+ + IL++ LR R CF + +
Sbjct: 675 PVPSDPQAELQFYLVVALALISVLFLLAVILAVALRLRRSSSPAAWSCFQPGLCVKSGPV 734
Query: 580 LPQELGDGTVPVG----IAHLTATVQAFTHC 606
+P GT+P +AH T F C
Sbjct: 735 VPPNYSQGTLPYSYNLCVAHTGKTEFNFLKC 765
>gi|11128031 protocadherin gamma subfamily B, 5 isoform 1 precursor
[Homo sapiens]
Length = 923
Score = 35.8 bits (81), Expect = 0.25
Identities = 23/91 (25%), Positives = 37/91 (40%), Gaps = 4/91 (4%)
Query: 520 PIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQI 579
P+P+ LQ +VV ++V+ + IL++ LR R CF + +
Sbjct: 675 PVPSDPQAELQFYLVVALALISVLFLLAVILAVALRLRRSSSPAAWSCFQPGLCVKSGPV 734
Query: 580 LPQELGDGTVPVG----IAHLTATVQAFTHC 606
+P GT+P +AH T F C
Sbjct: 735 VPPNYSQGTLPYSYNLCVAHTGKTEFNFLKC 765
>gi|208431781 cyclic nucleotide gated channel beta 1 isoform b [Homo
sapiens]
Length = 299
Score = 34.7 bits (78), Expect = 0.56
Identities = 26/82 (31%), Positives = 37/82 (45%), Gaps = 9/82 (10%)
Query: 1113 ILGPPPEVIQMYKESPEIL----SPPAPQGGGLRWGASSSLPQSFARVTTSMTVAIHPPP 1168
+L PP+ +++++ P + S PAP G G P+ AR T S+ I P
Sbjct: 169 VLPQPPKSSEVWRDEPAVATGAASDPAPPGRPQEMG-----PKLQARETPSLPTPIPLQP 223
Query: 1169 LPGAYIHPAPDEPPWSPAATSS 1190
PAP+ P S A TSS
Sbjct: 224 KEEPKEAPAPEPQPGSQAQTSS 245
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,895,730
Number of Sequences: 37866
Number of extensions: 2479232
Number of successful extensions: 9127
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 51
Number of HSP's that attempted gapping in prelim test: 8841
Number of HSP's gapped (non-prelim): 282
length of query: 1203
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1089
effective length of database: 13,930,794
effective search space: 15170634666
effective search space used: 15170634666
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.