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Search of human proteins with 52138725
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|52138725 leucine rich repeat and Ig domain containing 4
[Homo sapiens]
(593 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 1196 0.0
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 469 e-132
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 456 e-128
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 444 e-124
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 166 6e-41
gi|51317373 netrin-G1 ligand [Homo sapiens] 164 2e-40
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 163 4e-40
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 163 4e-40
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 160 3e-39
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 157 3e-38
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 155 1e-37
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 155 1e-37
gi|149773484 leucine rich repeat and fibronectin type III domain... 151 2e-36
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 149 9e-36
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens] 147 3e-35
gi|27363458 leucine rich repeat and fibronectin type III domain ... 147 4e-35
gi|225579152 insulin-like growth factor binding protein, acid la... 144 2e-34
gi|4826772 insulin-like growth factor binding protein, acid labi... 143 5e-34
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 140 3e-33
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 138 1e-32
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 138 1e-32
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 138 1e-32
gi|188528675 slit homolog 1 [Homo sapiens] 136 5e-32
gi|13375646 leucine rich repeat and fibronectin type III domain ... 136 6e-32
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 135 1e-31
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 133 4e-31
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 133 4e-31
gi|194440719 chondroadherin-like [Homo sapiens] 130 3e-30
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 127 2e-29
gi|31542244 leucine rich repeat and fibronectin type III domain ... 127 4e-29
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 1196 bits (3093), Expect = 0.0
Identities = 593/593 (100%), Positives = 593/593 (100%)
Query: 1 MDAATAPKQAWPPWPPLLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPL 60
MDAATAPKQAWPPWPPLLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPL
Sbjct: 1 MDAATAPKQAWPPWPPLLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPL 60
Query: 61 DTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRL 120
DTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRL
Sbjct: 61 DTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRL 120
Query: 121 RIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLA 180
RIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLA
Sbjct: 121 RIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLA 180
Query: 181 KLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPS 240
KLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPS
Sbjct: 181 KLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPS 240
Query: 241 LEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLV 300
LEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLV
Sbjct: 241 LEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLV 300
Query: 301 RLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPL 360
RLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPL
Sbjct: 301 RLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPL 360
Query: 361 TCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQGKSLKEFSDILPPGHFTCKPALIRKSGP 420
TCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQGKSLKEFSDILPPGHFTCKPALIRKSGP
Sbjct: 361 TCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQGKSLKEFSDILPPGHFTCKPALIRKSGP 420
Query: 421 RWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWLGRAGRVRVLEDGTLEIRSVQLRDRG 480
RWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWLGRAGRVRVLEDGTLEIRSVQLRDRG
Sbjct: 421 RWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWLGRAGRVRVLEDGTLEIRSVQLRDRG 480
Query: 481 AYVCVVSNVAGNDSLRTWLEVIQVEPPNGTLSDPNITVPGIPGPFFLDSRGVAMVLAVGF 540
AYVCVVSNVAGNDSLRTWLEVIQVEPPNGTLSDPNITVPGIPGPFFLDSRGVAMVLAVGF
Sbjct: 481 AYVCVVSNVAGNDSLRTWLEVIQVEPPNGTLSDPNITVPGIPGPFFLDSRGVAMVLAVGF 540
Query: 541 LPFLTSVTLCFGLIALWSKGKGRVKHHMTFDFVAPRPSGDKNSGGNRVTAKLF 593
LPFLTSVTLCFGLIALWSKGKGRVKHHMTFDFVAPRPSGDKNSGGNRVTAKLF
Sbjct: 541 LPFLTSVTLCFGLIALWSKGKGRVKHHMTFDFVAPRPSGDKNSGGNRVTAKLF 593
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 469 bits (1206), Expect = e-132
Identities = 258/583 (44%), Positives = 355/583 (60%), Gaps = 21/583 (3%)
Query: 14 WPPLLFLLL--LPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNR 71
W P+L L+L + GS CP C+C++Q +AVLC ++ AVP G+P +T LLDL NR
Sbjct: 23 WQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNR 82
Query: 72 LWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGL 131
+ L Q + L+EL+L+ N +S +EPGAF+ L +L TL L+ NRL+++ GVF+GL
Sbjct: 83 IKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGL 142
Query: 132 SALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCN 191
S LT LD+ N+IV+ LD F +L +L+ LEVGDN LV+++ AF+GL L LTLE+CN
Sbjct: 143 SNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCN 202
Query: 192 LSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVG 251
L+++P AL+ L L+ LRLR L+I + + + L +LK LEI WP L+ + P L G
Sbjct: 203 LTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYG 262
Query: 252 LNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGAC 311
LNL+SL+IT CNL++VP+ A+ HL +LR L+LS NPIS I L L+RLQE++L G
Sbjct: 263 LNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQ 322
Query: 312 LTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLR 371
L + +AF GL +L+V+ N L TLEE+ F S L TL L NPL CDCRLLW+ R
Sbjct: 323 LAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFR 382
Query: 372 LRRHLDFGMSPPACAGPHHVQGKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHA 431
R L+F P CA P VQGK K+F D+L P +FTC+ A IR + V +EG
Sbjct: 383 RRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTV 442
Query: 432 VFSCSGDGDPAPTVSWMRP--HGAWLGRAGRVRVLEDGTLEIRSVQLRDRGAYVCVVSNV 489
F C DGDP P + W+ P H GR+ V DGTLE+R Q++D G Y+C+ +N
Sbjct: 443 QFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANA 502
Query: 490 AGNDSLRTWLEVIQVEP-----PNGTLS---------DPNITVPGIPGPFFLDSRGVAMV 535
GNDS+ L V P PN T + + N T +P PF D + + +
Sbjct: 503 GGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPF--DIKTLIIA 560
Query: 536 LAVGFLPFLTSVTLCFGLIALWSKGKGRVKHHMTFDFVAPRPS 578
+GF+ FL V C L+ LWS+GKG KH++ ++V PR S
Sbjct: 561 TTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYV-PRKS 602
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 456 bits (1173), Expect = e-128
Identities = 252/581 (43%), Positives = 356/581 (61%), Gaps = 13/581 (2%)
Query: 11 WPPWPPLLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGN 70
W P+ L +L+ G + G CPA C+C++Q ++V C R+L A+P G+P++T++LDLS N
Sbjct: 9 WQPFLGLAVVLIFMGSTIG-CPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKN 67
Query: 71 RLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSG 130
RL + LL+E+DLS N ++ +EPGAF+ L +L +LRL+GNRL+++ GVF+G
Sbjct: 68 RLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTG 127
Query: 131 LSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERC 190
LS LT LD+ N+IV+ LD F +L +L+ LEVGDN LV+++ AF+GL L LTLE+C
Sbjct: 128 LSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKC 187
Query: 191 NLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLV 250
NL+ VP AL+ L +L++L L+ L+I +P A + L LK LEI WP L+ + SL
Sbjct: 188 NLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLY 247
Query: 251 GLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGA 310
GLNL+SL++T NLS+VPF A HL +L L+LS NPIS I A S L+RLQEL + GA
Sbjct: 248 GLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGA 307
Query: 311 CLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLL 370
L +I H+F GL +L+V+ N L+TLEE F SP L L ++ NPL CDCRLLW+L
Sbjct: 308 QLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWIL 367
Query: 371 RLRRHLDFGMSPPACAGPHHVQGKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGH 430
+ + L FG P CAGP ++ +S K+F +FTCK IR+ + ++ +EG
Sbjct: 368 QRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQT 427
Query: 431 AVFSCSGDGDPAPTVSWMRPHGAWLGRA--GRVRVLEDGTLEIRSVQLRDRGAYVCVVSN 488
CS DGDP P +SW+ P ++ GR VL DGTLEIR Q +D G YVC+ SN
Sbjct: 428 VQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASN 487
Query: 489 VAGNDSLRTWLEV----------IQVEPPNGTLSDPNITVPGIPGPFFLDSRGVAMVLAV 538
AGND+ L V P T S+ I+ F LD + + + A+
Sbjct: 488 AAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNANTFSLDLKTILVSTAM 547
Query: 539 GFLPFLTSVTLCFGLIALWSKGKGRVKHHMTFDFVAPRPSG 579
G FL V CF L+ +WS+GKG+ K+ + ++V + +G
Sbjct: 548 GCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNG 588
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 444 bits (1141), Expect = e-124
Identities = 258/576 (44%), Positives = 348/576 (60%), Gaps = 12/576 (2%)
Query: 16 PLLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGL 75
PLL L P +GG CPA C+CT Q +AV C R+L AVP G+P +T LL+LS NR+ L
Sbjct: 11 PLLLLPAAPPPAGG-CPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCL 69
Query: 76 QQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALT 135
G L+ L L+ELDLS N ++ +EPGAF L L LRL+GN+L+++ PGVF+ L LT
Sbjct: 70 NPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLT 129
Query: 136 LLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTV 195
LLDL N++V+ LD F +L SL++LEVGDN LVFV+ AFAGL L LTLERCNL+ +
Sbjct: 130 LLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTAL 189
Query: 196 PGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLNLS 255
G +L L +L ALRLR L I L R L L LEI WP LE + GSL GLNL+
Sbjct: 190 SGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLT 249
Query: 256 SLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSI 315
SL++T N+++VP AL H + L L+LS NPIS +P LVRL+EL L+GA L +
Sbjct: 250 SLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVV 309
Query: 316 AAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRH 375
AF GL LL++++N L TLEE+ F S + L TLR+ GNPL CDCRLLW+++ R+
Sbjct: 310 EPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKT 369
Query: 376 LDFGMSPPACAGPHHVQGKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSC 435
L+F PACA P V+G +L+ D + +F C+ IR+ + V A G F C
Sbjct: 370 LNFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFLC 429
Query: 436 SGDGDPAPTVSWMRP--HGAWLGRAGRVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGND 493
+G+PAPTV+W+ P AGR RVL GTLEI+ + +D G Y CV SN GND
Sbjct: 430 RAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTLEIQDARPQDSGTYTCVASNAGGND 489
Query: 494 SLRTWLEVIQVEPPNGTLSDP----NITVPGIPGPFFLDSRGVAMVLAVGFLPFLTSVTL 549
T+ + V P P N T+ + P LD + + A+G + FL V
Sbjct: 490 ---TYFATLTVRPEPAANRTPGEAHNETLAALRAP--LDLTTILVSTAMGCITFLGVVLF 544
Query: 550 CFGLIALWSKGKGRVKHHMTFDFVAPRPSGDKNSGG 585
CF L+ +WS+G+G+ K++ + ++ + G + G
Sbjct: 545 CFVLLFVWSRGRGQHKNNFSVEYSFRKVDGPAAAAG 580
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 166 bits (420), Expect = 6e-41
Identities = 144/482 (29%), Positives = 205/482 (42%), Gaps = 87/482 (18%)
Query: 30 SCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQEL 89
+CP+VC C++Q V+C R L VP G+P +T L+L
Sbjct: 45 NCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLME-------------------- 84
Query: 90 DLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLD 149
N + ++ F L L L+L N +R + G F+G
Sbjct: 85 ----NNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNG------------------- 121
Query: 150 GAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVAL 209
L SL LE+ DN L + GAF L+KL L L + ++P A R+P+L+ L
Sbjct: 122 -----LASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRL 176
Query: 210 RLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGL-NLSSLAITRCNLSSVP 268
LG+LK+LE + G+ GL NL L + CN+ +P
Sbjct: 177 ----------------DLGELKKLEY--------ISEGAFEGLFNLKYLNLGMCNIKDMP 212
Query: 269 FQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHL 328
L L L L++S N I L L++L + + ++ I +AF GL +
Sbjct: 213 --NLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVE 270
Query: 329 LDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLL-RLRRHLDFGMS-PPACA 386
L++A N L +L F LV L L NP CDC +LWL LR ++ + C
Sbjct: 271 LNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCH 330
Query: 387 GPHHVQGKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVS 446
P H++G+ L E + F C I PR + EG A C P +V
Sbjct: 331 APMHMRGRYLVE----VDQASFQCSAPFI-MDAPRDLNISEGRMAELKCR--TPPMSSVK 383
Query: 447 WMRPHGAWLGRAG---RVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQ 503
W+ P+G L A R+ VL DGTL V L D G Y C+V+NVAGN + +L V
Sbjct: 384 WLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVST 443
Query: 504 VE 505
E
Sbjct: 444 AE 445
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 164 bits (415), Expect = 2e-40
Identities = 139/481 (28%), Positives = 210/481 (43%), Gaps = 92/481 (19%)
Query: 30 SCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQEL 89
+CP+VC C++Q V+C + L VP G+ +T LL+L N++ ++ L L+ L
Sbjct: 46 TCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEIL 105
Query: 90 DLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLD 149
LS N + T+E GAF+GL +L TL L NRL + G F LS L L LR N I
Sbjct: 106 QLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPS 165
Query: 150 GAFGELGSLQKLEVGD-NHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVA 208
AF + SL++L++G+ L +++ GAF GL+ L L L CNL +P L
Sbjct: 166 YAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLT-------PL 218
Query: 209 LRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGL-NLSSLAITRCNLSSV 267
++L ELD+ L A+ PGS GL +L L + + + +
Sbjct: 219 IKLDELDLS--------------------GNHLSAIRPGSFQGLMHLQKLWMIQSQIQVI 258
Query: 268 PFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFH 327
A +L L ++L+ N ++ +P +PL L+ + H H
Sbjct: 259 ERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERI------------HLHH------ 300
Query: 328 LLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAG 387
NP C+C +LWL + D S AC
Sbjct: 301 ------------------------------NPWNCNCDILWLSWWIK--DMAPSNTACCA 328
Query: 388 ----PHHVQGKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAP 443
P +++G+ + E L +FTC +I + P + EG A C
Sbjct: 329 RCNTPPNLKGRYIGE----LDQNYFTCYAPVIVEP-PADLNVTEGMAAELKCRA-STSLT 382
Query: 444 TVSWMRPHGAWLGRAG---RVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLE 500
+VSW+ P+G + R+ VL DGTL +V ++D G Y C+VSN GN + L
Sbjct: 383 SVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLN 442
Query: 501 V 501
V
Sbjct: 443 V 443
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 163 bits (413), Expect = 4e-40
Identities = 153/506 (30%), Positives = 211/506 (41%), Gaps = 69/506 (13%)
Query: 31 CPAVCDCTSQP-----------QAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGM 79
CP C C +P V C L AVP LP T+ L L N + + Q
Sbjct: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
Query: 80 LSRLSLLQELDLSY------------------------NQLSTLEPGAFHGLQSLLTLRL 115
L L+ L ELDLS NQL+ LE +F GL SL L L
Sbjct: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
Query: 116 QGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGA 175
N+L + P FSGLS L L L N + F L +L+ L +G N + +
Sbjct: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
Query: 176 FAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEI 235
F LA L +L L NL + AL L +L +L + + R+P AL + LK L++
Sbjct: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDL 268
Query: 236 HLWPSLEALDPGSLVG-LNLSSLAITRC-NLSSVPFQALYHLSFLRVLDLSQNPISAIPA 293
+ P L+ + PG L+L L + L S+ AL +L L LD++ NP
Sbjct: 269 NKNP-LQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNP------ 321
Query: 294 RRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTL 353
L+ I AFH L L + +NAL L + S L +
Sbjct: 322 -----------------RLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEV 364
Query: 354 RLSGNPLTCDCRLLWLLRLRRHLDFGMSPPA--CAGPHHVQGKSLKEFSDILPPGHFTCK 411
L GNP+ CDC + W + F + P + CA P +Q ++E H C
Sbjct: 365 GLHGNPIRCDCVIRWANATGTRVRF-IEPQSTLCAEPPDLQRLPVREVPFREMTDH--CL 421
Query: 412 PALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWL--GRAG-RVRVLEDGT 468
P + +S P + G V C +P P + W+ P G L AG R RV +GT
Sbjct: 422 PLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGT 481
Query: 469 LEIRSVQLRDRGAYVCVVSNVAGNDS 494
LE+R V + G Y CV N+ G D+
Sbjct: 482 LELRRVTAEEAGLYTCVAQNLVGADT 507
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 163 bits (413), Expect = 4e-40
Identities = 153/506 (30%), Positives = 211/506 (41%), Gaps = 69/506 (13%)
Query: 31 CPAVCDCTSQP-----------QAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGM 79
CP C C +P V C L AVP LP T+ L L N + + Q
Sbjct: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
Query: 80 LSRLSLLQELDLSY------------------------NQLSTLEPGAFHGLQSLLTLRL 115
L L+ L ELDLS NQL+ LE +F GL SL L L
Sbjct: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
Query: 116 QGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGA 175
N+L + P FSGLS L L L N + F L +L+ L +G N + +
Sbjct: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
Query: 176 FAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEI 235
F LA L +L L NL + AL L +L +L + + R+P AL + LK L++
Sbjct: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDL 268
Query: 236 HLWPSLEALDPGSLVG-LNLSSLAITRC-NLSSVPFQALYHLSFLRVLDLSQNPISAIPA 293
+ P L+ + PG L+L L + L S+ AL +L L LD++ NP
Sbjct: 269 NKNP-LQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNP------ 321
Query: 294 RRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTL 353
L+ I AFH L L + +NAL L + S L +
Sbjct: 322 -----------------RLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEV 364
Query: 354 RLSGNPLTCDCRLLWLLRLRRHLDFGMSPPA--CAGPHHVQGKSLKEFSDILPPGHFTCK 411
L GNP+ CDC + W + F + P + CA P +Q ++E H C
Sbjct: 365 GLHGNPIRCDCVIRWANATGTRVRF-IEPQSTLCAEPPDLQRLPVREVPFREMTDH--CL 421
Query: 412 PALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWL--GRAG-RVRVLEDGT 468
P + +S P + G V C +P P + W+ P G L AG R RV +GT
Sbjct: 422 PLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGT 481
Query: 469 LEIRSVQLRDRGAYVCVVSNVAGNDS 494
LE+R V + G Y CV N+ G D+
Sbjct: 482 LELRRVTAEEAGLYTCVAQNLVGADT 507
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 160 bits (405), Expect = 3e-39
Identities = 153/528 (28%), Positives = 219/528 (41%), Gaps = 112/528 (21%)
Query: 12 PPWPP---------LLFLLLL--PGGSGG-----------------SCPAVCDCTSQPQA 43
PP PP LLFL L P G+GG SCP C C++Q
Sbjct: 10 PPLPPGRMSWPHGALLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVACSCSNQASR 69
Query: 44 VLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGA 103
V+C R L VP +P++T L+
Sbjct: 70 VICTRRDLAEVPASIPVNTRYLN------------------------------------- 92
Query: 104 FHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEV 163
LQ N ++++ F L L +L L N + GAF L SL LE+
Sbjct: 93 -----------LQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLEL 141
Query: 164 GDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGA 223
DN L V AF L+KL L L + ++P A R+P+L R LD
Sbjct: 142 FDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSL-----RRLD-------- 188
Query: 224 LRGLGQLKELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDL 283
LG+LK LE + E L +NL L + CNL +P L L L L+L
Sbjct: 189 ---LGELKRLEYISEAAFEGL-------VNLRYLNLGMCNLKDIP--NLTALVRLEELEL 236
Query: 284 SQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETA 343
S N + I L L++L L A + +I +AF L + L+++ N L +L
Sbjct: 237 SGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDL 296
Query: 344 FPSPDKLVTLRLSGNPLTCDCRLLWL-LRLRRHLDFGMSPPA-CAGPHHVQGKSLKEFSD 401
F +L + L+ NP C+C +LWL L+ + + A C P ++G+ + E
Sbjct: 297 FTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGE--- 353
Query: 402 ILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWLGRAG-- 459
L HFTC +I + P + EG A C G +V+W+ P+G +
Sbjct: 354 -LDQSHFTCYAPVIVEP-PTDLNVTEGMAAELKCR-TGTSMTSVNWLTPNGTLMTHGSYR 410
Query: 460 -RVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEP 506
R+ VL DGTL +V ++D G Y C+V+N AGN + L V V+P
Sbjct: 411 VRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDP 458
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 157 bits (396), Expect = 3e-38
Identities = 155/487 (31%), Positives = 231/487 (47%), Gaps = 35/487 (7%)
Query: 32 PAVCDCTSQPQAVLCGHRQLEAVPGG---LPLDTELLDLSGNRLWGLQQGMLSRLSLLQE 88
P++ +S ++ H ++ +V G L E+LDLS N + ++ ++E
Sbjct: 108 PSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKE 167
Query: 89 LDLSYNQLSTLEPGAFHGL-QSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLF 147
L+L+ N++ TLE GAF GL +SLLTLRL NR+ + F L LT LDL N+I L
Sbjct: 168 LNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLI 226
Query: 148 LDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALV 207
F L SL+ L++ N++ + GAF GL+K+ L LE +L V +L L AL
Sbjct: 227 EGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALH 286
Query: 208 ALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLN-LSSLAITRCNLSS 266
L L I R+ +L EL + + +L LD SL L+ LS L ++ ++S
Sbjct: 287 QLHLSNNSIARIHRKGWSFCQKLHELVLS-FNNLTRLDEESLAELSSLSVLRLSHNSISH 345
Query: 267 VPFQALYHLSFLRVLDLSQNPISAI---PARRLSPLVRLQELRLSGACLTSIAAHAFHGL 323
+ A L LRVLDL N IS + S L L +L L G + S+A AF GL
Sbjct: 346 IAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGL 405
Query: 324 TAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWL--LRLRRHLDFGMS 381
L++ NA+++++ AF L L +S + CDC+L WL + R L
Sbjct: 406 EGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQ-AFV 464
Query: 382 PPACAGPHHVQGKSLKEFSDILPPGHFTC----KPALIRKSGPRWVIAEEGGHAVFSCSG 437
CA P ++G+S+ FS +PP F C KP +I + P +A G F+CS
Sbjct: 465 TATCAHPESLKGQSI--FS--VPPESFVCDDFLKPQIITQ--PETTMAMVGKDIRFTCSA 518
Query: 438 DGDPAP--TVSWMRPHGAWLG---------RAGRVRVLEDGT-LEIRSVQLRDRGAYVCV 485
+ T +W + + A V+E T L +R V G Y CV
Sbjct: 519 ASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCV 578
Query: 486 VSNVAGN 492
++N G+
Sbjct: 579 ITNHFGS 585
Score = 40.4 bits (93), Expect = 0.005
Identities = 26/91 (28%), Positives = 40/91 (43%), Gaps = 3/91 (3%)
Query: 431 AVFSCSGDGDPAPTVSWMRPHGAWL--GRAGRVRVL-EDGTLEIRSVQLRDRGAYVCVVS 487
A C+ G P P ++W + G R R+ V+ +D I V++ D G Y C
Sbjct: 616 ARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQ 675
Query: 488 NVAGNDSLRTWLEVIQVEPPNGTLSDPNITV 518
N AG+ S L V++ L D ++V
Sbjct: 676 NSAGSISANATLTVLETPSLVVPLEDRVVSV 706
Score = 35.4 bits (80), Expect = 0.15
Identities = 20/80 (25%), Positives = 33/80 (41%), Gaps = 2/80 (2%)
Query: 424 IAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWLGRAGRVRVLEDGTL-EIRSVQLRDRGAY 482
+ G C G+P P ++W + L R + D L +++V D G Y
Sbjct: 703 VVSVGETVALQCKATGNPPPRITWFKGDRP-LSLTERHHLTPDNQLLVVQNVVAEDAGRY 761
Query: 483 VCVVSNVAGNDSLRTWLEVI 502
C +SN G + + L V+
Sbjct: 762 TCEMSNTLGTERAHSQLSVL 781
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 155 bits (391), Expect = 1e-37
Identities = 158/499 (31%), Positives = 240/499 (48%), Gaps = 37/499 (7%)
Query: 45 LCGHRQLEAVPGGLP--LDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPG 102
L G+R +E +P L E LDLS N + LQ + L+ L L+ N+++++EPG
Sbjct: 128 LAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQ--LKYLYLNSNRVTSMEPG 185
Query: 103 AFHGL-QSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKL 161
F L +LL L+L NR+ + P +F L L L+L N+I F LG+L+ L
Sbjct: 186 YFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSL 244
Query: 162 EVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPA 221
++ N + + GAF GL+ + L L+ NL+ + L L L L L + I R+
Sbjct: 245 KMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISP 304
Query: 222 GALRGLGQLKELEIHLWPSLEALDPGSLVGLNL-SSLAITRCNLSSVPFQALYHLSFLRV 280
A +L EL++ + L LD S +GL+L ++L I +S + A LS L+
Sbjct: 305 DAWEFCQKLSELDL-TFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKT 363
Query: 281 LDLSQNPISAIPARR---LSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQ 337
LDL N IS S L +L+ L L G + SI AF GL A LD++DNA+
Sbjct: 364 LDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIM 423
Query: 338 TLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDF-GMSPPACAGPHHVQGKSL 396
+L+ AF KL L L+ + L CDC+L WL + +F +CA P ++G+S+
Sbjct: 424 SLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSI 483
Query: 397 KEFSDILPPGHFTC----KPALIRKSGPRWVIAEEGGHAVFSCS--GDGDPAPTVSWMRP 450
S P F C KP + + P A +G + F CS D T +W +
Sbjct: 484 FAVS----PDGFVCDDFPKPQITVQ--PETQSAIKGSNLSFICSAASSSDSPMTFAWKKD 537
Query: 451 ----HGAWLGRAGRVR-----VLEDGT-LEIRSVQLRDRGAYVCVVSNVAGND-SLRTWL 499
H A + +R V+E T L +R V+ G Y CV+SN G+ S++ L
Sbjct: 538 NELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKL 597
Query: 500 EVIQVEPPNGTLSDPNITV 518
V + P+ T + ++T+
Sbjct: 598 TVNML--PSFTKTPMDLTI 614
Score = 94.4 bits (233), Expect = 3e-19
Identities = 125/478 (26%), Positives = 185/478 (38%), Gaps = 57/478 (11%)
Query: 63 ELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRI 122
E+L L N L + +G L L +LQEL LS N ++ + P A+ Q L L L N L
Sbjct: 266 EILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSR 325
Query: 123 MGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAP---GAFAGL 179
+ F GLS L L + N++ D AF L SL+ L++ +N + + GAF+GL
Sbjct: 326 LDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGL 385
Query: 180 AKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWP 239
KL L L+ + ++ A L AL L L + I L A + +L++L
Sbjct: 386 DKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLH----- 440
Query: 240 SLEALDPGSLVGLNLSSLAITRCNLSSVP-------FQALYHLSFLRVLDLSQNPISAIP 292
LN SSL + C L +P FQ+ + S L I A+
Sbjct: 441 ------------LNTSSL-LCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVS 487
Query: 293 ARRL------SPLVRLQ---ELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETA 343
P + +Q + + G+ L+ I + A + DN L E
Sbjct: 488 PDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEM- 546
Query: 344 FPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQGK-SLKEFSDI 402
+ LR G + +LRLR C +H S+K +
Sbjct: 547 ----ENYAHLRAQGGEVM---EYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTV 599
Query: 403 LPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWL--GRAGR 460
FT P + G A C+ G PAP ++W + G R R
Sbjct: 600 NMLPSFT--------KTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERR 651
Query: 461 VRVL-EDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPPNGTLSDPNIT 517
+ V+ ED I V++ D G Y C N AG+ S L V++ L D +T
Sbjct: 652 MHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVT 709
Score = 39.7 bits (91), Expect = 0.008
Identities = 25/95 (26%), Positives = 36/95 (37%), Gaps = 4/95 (4%)
Query: 427 EGGHAVFSCSGDGDPAPTVSWMRPHGAWLGRAGRVRVLEDGTLEIRSVQLRDRGAYVCVV 486
+G AV C G P P ++W + + + L I + D G Y C +
Sbjct: 710 KGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEM 769
Query: 487 SNVAGNDSLRTWLEVIQVEPPNGTLSDPNITVPGI 521
SN G + L VI P T P +T P +
Sbjct: 770 SNTLGTERGNVRLSVI----PTPTCDSPQMTAPSL 800
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 155 bits (391), Expect = 1e-37
Identities = 158/499 (31%), Positives = 240/499 (48%), Gaps = 37/499 (7%)
Query: 45 LCGHRQLEAVPGGLP--LDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPG 102
L G+R +E +P L E LDLS N + LQ + L+ L L+ N+++++EPG
Sbjct: 68 LAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQ--LKYLYLNSNRVTSMEPG 125
Query: 103 AFHGL-QSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKL 161
F L +LL L+L NR+ + P +F L L L+L N+I F LG+L+ L
Sbjct: 126 YFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSL 184
Query: 162 EVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPA 221
++ N + + GAF GL+ + L L+ NL+ + L L L L L + I R+
Sbjct: 185 KMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISP 244
Query: 222 GALRGLGQLKELEIHLWPSLEALDPGSLVGLNL-SSLAITRCNLSSVPFQALYHLSFLRV 280
A +L EL++ + L LD S +GL+L ++L I +S + A LS L+
Sbjct: 245 DAWEFCQKLSELDL-TFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKT 303
Query: 281 LDLSQNPISAIPARR---LSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQ 337
LDL N IS S L +L+ L L G + SI AF GL A LD++DNA+
Sbjct: 304 LDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIM 363
Query: 338 TLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDF-GMSPPACAGPHHVQGKSL 396
+L+ AF KL L L+ + L CDC+L WL + +F +CA P ++G+S+
Sbjct: 364 SLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSI 423
Query: 397 KEFSDILPPGHFTC----KPALIRKSGPRWVIAEEGGHAVFSCS--GDGDPAPTVSWMRP 450
S P F C KP + + P A +G + F CS D T +W +
Sbjct: 424 FAVS----PDGFVCDDFPKPQITVQ--PETQSAIKGSNLSFICSAASSSDSPMTFAWKKD 477
Query: 451 ----HGAWLGRAGRVR-----VLEDGT-LEIRSVQLRDRGAYVCVVSNVAGND-SLRTWL 499
H A + +R V+E T L +R V+ G Y CV+SN G+ S++ L
Sbjct: 478 NELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKL 537
Query: 500 EVIQVEPPNGTLSDPNITV 518
V + P+ T + ++T+
Sbjct: 538 TVNML--PSFTKTPMDLTI 554
Score = 94.4 bits (233), Expect = 3e-19
Identities = 125/478 (26%), Positives = 185/478 (38%), Gaps = 57/478 (11%)
Query: 63 ELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRI 122
E+L L N L + +G L L +LQEL LS N ++ + P A+ Q L L L N L
Sbjct: 206 EILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSR 265
Query: 123 MGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAP---GAFAGL 179
+ F GLS L L + N++ D AF L SL+ L++ +N + + GAF+GL
Sbjct: 266 LDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGL 325
Query: 180 AKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWP 239
KL L L+ + ++ A L AL L L + I L A + +L++L
Sbjct: 326 DKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLH----- 380
Query: 240 SLEALDPGSLVGLNLSSLAITRCNLSSVP-------FQALYHLSFLRVLDLSQNPISAIP 292
LN SSL + C L +P FQ+ + S L I A+
Sbjct: 381 ------------LNTSSL-LCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVS 427
Query: 293 ARRL------SPLVRLQ---ELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETA 343
P + +Q + + G+ L+ I + A + DN L E
Sbjct: 428 PDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEM- 486
Query: 344 FPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQGK-SLKEFSDI 402
+ LR G + +LRLR C +H S+K +
Sbjct: 487 ----ENYAHLRAQGGEVM---EYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTV 539
Query: 403 LPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWL--GRAGR 460
FT P + G A C+ G PAP ++W + G R R
Sbjct: 540 NMLPSFT--------KTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERR 591
Query: 461 VRVL-EDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPPNGTLSDPNIT 517
+ V+ ED I V++ D G Y C N AG+ S L V++ L D +T
Sbjct: 592 MHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVT 649
Score = 39.7 bits (91), Expect = 0.008
Identities = 25/95 (26%), Positives = 36/95 (37%), Gaps = 4/95 (4%)
Query: 427 EGGHAVFSCSGDGDPAPTVSWMRPHGAWLGRAGRVRVLEDGTLEIRSVQLRDRGAYVCVV 486
+G AV C G P P ++W + + + L I + D G Y C +
Sbjct: 650 KGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEM 709
Query: 487 SNVAGNDSLRTWLEVIQVEPPNGTLSDPNITVPGI 521
SN G + L VI P T P +T P +
Sbjct: 710 SNTLGTERGNVRLSVI----PTPTCDSPQMTAPSL 740
Score = 34.3 bits (77), Expect = 0.33
Identities = 30/110 (27%), Positives = 53/110 (48%), Gaps = 5/110 (4%)
Query: 253 NLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPL-VRLQELRLSGAC 311
++S ++ LS + ++ HL LR + L+ N + IP L P+ + L L+G
Sbjct: 15 HISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP--NLGPVSANITLLSLAGNR 72
Query: 312 LTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLT 361
+ I + LD++ N + L +TAFP+ +L L L+ N +T
Sbjct: 73 IVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVT 120
>gi|149773484 leucine rich repeat and fibronectin type III domain
containing 1 [Homo sapiens]
Length = 771
Score = 151 bits (381), Expect = 2e-36
Identities = 120/381 (31%), Positives = 158/381 (41%), Gaps = 48/381 (12%)
Query: 160 KLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRL 219
+L + DN + V FA + L LTL R + V A A L AL AL L + +
Sbjct: 69 ELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEV 128
Query: 220 PAGALRGLGQLKELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLR 279
LRGLG L+ L ++G N I R + S F A LS +
Sbjct: 129 RGDQLRGLGNLRHL---------------ILGNN----QIRR--VESAAFDAF--LSTVE 165
Query: 280 VLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTL 339
LDLS N + A+P + +V L L L + IA F L LD+ N L L
Sbjct: 166 DLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKL 225
Query: 340 EETAF--------PSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGPHHV 391
P P +T+ GNPL C+C LLWL RL R D CA P H+
Sbjct: 226 PPDGLFLRSQGTGPKPPTPLTVSFGGNPLHCNCELLWLRRLTREDDL----ETCATPEHL 281
Query: 392 QGKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPH 451
+ +P F C+P LI + + EG C GDP P V W+ P
Sbjct: 282 TDRYFWS----IPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPD 337
Query: 452 GAWLGRAGRVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQV------- 504
G LG + R RV DGTL++ LRD G + C+ SN AG + + V+ +
Sbjct: 338 GRLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPP 397
Query: 505 --EPPNGTLSDPNITVPGIPG 523
PP +I PG PG
Sbjct: 398 AAPPPLTEPGSSDIATPGRPG 418
Score = 68.2 bits (165), Expect = 2e-11
Identities = 64/218 (29%), Positives = 97/218 (44%), Gaps = 5/218 (2%)
Query: 12 PPWPPLLFLLLLPGGS--GGSCPAVCDC--TSQPQAVLCGHRQLEAVPGGLPLDTELLDL 67
PP L FLLLL G+ G CP C C + +LC L VP + L L
Sbjct: 13 PPPAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRL 72
Query: 68 SGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGV 127
+ N + +++ + ++ L L LS N + + GAF L++L L L NRL +
Sbjct: 73 TDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQ 132
Query: 128 FSGLSALTLLDLRLNQIVLFLDGAFGE-LGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLT 186
GL L L L NQI AF L +++ L++ N+L + A + L+TLT
Sbjct: 133 LRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLT 192
Query: 187 LERCNLSTVPGLALARLPALVALRLRELDIGRLPAGAL 224
L+ + + +L LV L + + +LP L
Sbjct: 193 LDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGL 230
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 149 bits (375), Expect = 9e-36
Identities = 131/436 (30%), Positives = 187/436 (42%), Gaps = 58/436 (13%)
Query: 10 AWPPWPPLLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLP---------- 59
AW W LL L CP CDC Q V C +L VP +P
Sbjct: 5 AWLLWTSLLLL----ARPAQPCPMGCDCFVQE--VFCSDEELATVPLDIPPYTKNIIFVE 58
Query: 60 ----------------------LDTEL----------------LDLSGNRLWGLQQGMLS 81
L+T+L L+++G+ L + S
Sbjct: 59 TSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFS 118
Query: 82 RLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRL 141
L+ L +L L++N L L G F L +L +L LQGN+L+ + +F L+ L L+L
Sbjct: 119 NLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQ 178
Query: 142 NQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALA 201
N + + F L SLQ L++ +N L + G F L L L L+ N+S +P +
Sbjct: 179 NLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFS 238
Query: 202 RLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLN-LSSLAIT 260
+L L L L+ I LP LG L L + W L L G L L++T
Sbjct: 239 QLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQ-WNMLRVLPAGLFAHTPCLVGLSLT 297
Query: 261 RCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAF 320
L +V HLS LR L LS N I+ +PA L L +L L LT++ F
Sbjct: 298 HNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALF 357
Query: 321 HGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLR-LRRHLDFG 379
L+ LL ++ N L TL E F + L L L GNP CDC L +L L+++ D
Sbjct: 358 QNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRL 417
Query: 380 MS-PPACAGPHHVQGK 394
++ CAGP +++G+
Sbjct: 418 LNIQTYCAGPAYLKGQ 433
>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
Length = 716
Score = 147 bits (371), Expect = 3e-35
Identities = 135/523 (25%), Positives = 221/523 (42%), Gaps = 72/523 (13%)
Query: 31 CPAVCDCTSQP-----------QAVLCGHRQLEAVPGGLPLDTELL-------------- 65
CP +C C +P V C +L +P L DT++L
Sbjct: 32 CPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKTVDEL 91
Query: 66 ---------DLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQ 116
D S N +++ L+ L+ L L L NQ++ + L +L L +
Sbjct: 92 QQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYIN 151
Query: 117 GNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAF 176
N++ + F+GL L L L N++ + F +L+ L +G+N ++ + F
Sbjct: 152 HNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNF 211
Query: 177 AGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIH 236
LA L +L L L+ +PG AL L +L +L + + ++P AL+ + LK L+++
Sbjct: 212 KPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLN 271
Query: 237 LWPSLEALDPGSLVGLNLSSLAITRC-NLSSVPFQALYHLSFLRVLDLSQNPISAIPARR 295
P + + L L L I L SV AL +L L L+ + NP +
Sbjct: 272 KNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNP-------K 324
Query: 296 LSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRL 355
LS + RL AF + A L + +NAL + + S L + +
Sbjct: 325 LSYIHRL----------------AFRSVPALESLMLNNNALNAIYQKTVESLPNLREISI 368
Query: 356 SGNPLTCDCRLLWLLRLRRHLDFGMSPPA--CAGPHHVQGKSLKEFSDILPPGHFTCKPA 413
NPL CDC + W+ + ++ F M P + CA P +G +KE ++ C P
Sbjct: 369 HSNPLRCDCVIHWINSNKTNIRF-MEPLSMFCAMPPEYKGHQVKEV--LIQDSSEQCLPM 425
Query: 414 LIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWL---GRAGRVRVLEDGTLE 470
+ S P + + G C +P P + W+ P G + + + ++ +GTLE
Sbjct: 426 ISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLE 485
Query: 471 IRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPPNGTLSD 513
I ++Q+ D G Y CV NV G D+ ++V NGTL D
Sbjct: 486 ISNIQIEDSGRYTCVAQNVQGADTRVATIKV------NGTLLD 522
>gi|27363458 leucine rich repeat and fibronectin type III domain
containing 4 [Homo sapiens]
Length = 635
Score = 147 bits (370), Expect = 4e-35
Identities = 128/410 (31%), Positives = 183/410 (44%), Gaps = 42/410 (10%)
Query: 160 KLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRL 219
+L + DN + + P F + L LTL R ++ + A L +L +L L + L
Sbjct: 52 ELRLADNFIQALGPPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVEL 111
Query: 220 PAGALRGLGQLKELEIHLWPSLEALDPGSLVGL--NLSSLAITRCNLSSVPFQALYHLSF 277
G+LRG L+ L I L + PG+ +L L ++ NL VP+ + +
Sbjct: 112 GTGSLRGPVNLQHL-ILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPA 170
Query: 278 LRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQ 337
L L+L N I A+P + L +L L LT+ L +A + L
Sbjct: 171 LHTLNLDHNLIDALPPGAFAQLGQLSRL----------------DLTSNRLATLAPDPLF 214
Query: 338 TLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQGKSLK 397
+ A SP LV L SGNPL C+C LLWL RL R D CA P + G+
Sbjct: 215 SRGRDAEASPAPLV-LSFSGNPLHCNCELLWLRRLARPDDL----ETCASPPGLAGR--- 266
Query: 398 EFSDILPPGHFTCKPALIRKSGPR-WVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWLG 456
+ +P G F+C+P LI + R WV+ EG A C GDPAPT+ W+ P +G
Sbjct: 267 -YFWAVPEGEFSCEPPLIARHTQRLWVL--EGQRATLRCRALGDPAPTMHWVGPDDRLVG 323
Query: 457 RAGRVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPPNGTLSDPNI 516
+ R R +GTLEI D G Y C+ +N AG + R L V+ + P+G S
Sbjct: 324 NSSRARAFPNGTLEIGVTGAGDAGGYTCIATNPAGEATARVELRVLAL--PHGGNSSAE- 380
Query: 517 TVPGIPGPFFLDSRGVAMVLAVGFLPF-----LTSVTLCFGLIALWSKGK 561
G PGP + + G L +T VT GL++ W G+
Sbjct: 381 --GGRPGPSDIAASARTAAEGEGTLESEPAVQVTEVTATSGLVS-WGPGR 427
Score = 94.7 bits (234), Expect = 2e-19
Identities = 76/222 (34%), Positives = 98/222 (44%), Gaps = 25/222 (11%)
Query: 15 PPLLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWG 74
PPLL LLL G + P VC S+ + LC HR L VP + T L L+ N +
Sbjct: 3 PPLLLLLLASGAAACPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQA 62
Query: 75 LQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSAL 134
L ++ L +L LS N ++ + AF L+SL +L L GNRL +G G G
Sbjct: 63 LGPPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGPV-- 120
Query: 135 TLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAG-LAKLSTLTLERCNLS 193
+LQ L + N L +APGAF L L L L NL
Sbjct: 121 ----------------------NLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLR 158
Query: 194 TVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEI 235
VP + +PAL L L I LP GA LGQL L++
Sbjct: 159 QVPWAGIGAMPALHTLNLDHNLIDALPPGAFAQLGQLSRLDL 200
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 144 bits (364), Expect = 2e-34
Identities = 134/425 (31%), Positives = 184/425 (43%), Gaps = 62/425 (14%)
Query: 7 PKQAWPPWPPLLFLLLL------------------PG-GSGGSCPAVCDCTSQPQA---- 43
P QA PP L LLL PG G +CPA C C+ A
Sbjct: 36 PPQASPPAGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELS 95
Query: 44 VLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGA 103
V C R L +P G+P T+ L L GN L + LS L L+L QL +LEP A
Sbjct: 96 VFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQA 155
Query: 104 FHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEV 163
GL++L L L+ N+LR + G F+ AL L L N++ DG F LGSL L +
Sbjct: 156 LLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNL 215
Query: 164 G------------------------DNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLA 199
G N L ++ P F+GLA+L L L R L +
Sbjct: 216 GWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANV 275
Query: 200 LARLPALVALRLRELDIGRLPAGALRGLGQLKELEI---HLWPSLEALDPGSLVGLNLSS 256
+LP L L L I + GA GL L+ L++ + LE PG L+GL +
Sbjct: 276 FVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPG-LLGLRV-- 332
Query: 257 LAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIA 316
L ++ ++S+ + L FL L L N I + R L +L+ L L L +
Sbjct: 333 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 392
Query: 317 AHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHL 376
A AF GLT +++++ N L+ L E F KL +L L G+ L R+R H
Sbjct: 393 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLG---------RIRPHT 443
Query: 377 DFGMS 381
G+S
Sbjct: 444 FTGLS 448
Score = 137 bits (344), Expect = 4e-32
Identities = 108/301 (35%), Positives = 146/301 (48%), Gaps = 8/301 (2%)
Query: 65 LDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMG 124
L LS NRL L+ G+ L L +L+L +N L+ L AF GL SL L L GNRL +
Sbjct: 189 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQ 248
Query: 125 PGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLST 184
P +FSGL+ L LDL N + F +L LQKL + N + VAPGAF GL L
Sbjct: 249 PALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRW 308
Query: 185 LTLERCNLSTVPGLALARLPALVALRLRELD---IGRLPAGALRGLGQLKELEIHLWPSL 241
L L + V GL P L+ LR+ L I L + L L+EL++ +
Sbjct: 309 LDLSH---NRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLG-HNRI 364
Query: 242 EALDPGSLVGL-NLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLV 300
L S GL L L + L V A L+ + V++LS N + +P + L
Sbjct: 365 RQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLG 424
Query: 301 RLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPL 360
+L L L G+CL I H F GL+ L + DN L +EE + +L+ L L+ N L
Sbjct: 425 KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQL 484
Query: 361 T 361
T
Sbjct: 485 T 485
Score = 94.7 bits (234), Expect = 2e-19
Identities = 101/356 (28%), Positives = 149/356 (41%), Gaps = 63/356 (17%)
Query: 52 EAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLL 111
+ PG L L +L LS N + L+ L L+EL L +N++ L +F GL L
Sbjct: 322 DTFPGLLGL--RVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLE 379
Query: 112 TLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFV 171
L L N+L+ + G F GL+ + +++L N + + F LG L L + + L +
Sbjct: 380 VLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRI 439
Query: 172 APGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLK 231
P F GL+ L L L+ L + +L L L+ L L + LP +GLG+L+
Sbjct: 440 RPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLE 499
Query: 232 ELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAI 291
L ++R L+ +P AL L LD+S N + A+
Sbjct: 500 ------------------------YLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEAL 535
Query: 292 PARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLV 351
P L+PL RL+ L L +N+L+T P P L
Sbjct: 536 PNSLLAPLGRLRYLSL------------------------RNNSLRTFT----PQPPGLE 567
Query: 352 TLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQGKSLKEFSDILPPGH 407
L L GNP C C L L DF + P+ A P VQ ++ E D PP +
Sbjct: 568 RLWLEGNPWDCGCPLKAL------RDFALQNPS-AVPRFVQ--AICEGDDCQPPAY 614
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 143 bits (360), Expect = 5e-34
Identities = 125/390 (32%), Positives = 175/390 (44%), Gaps = 44/390 (11%)
Query: 24 PG-GSGGSCPAVCDCTSQPQA----VLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQG 78
PG G +CPA C C+ A V C R L +P G+P T+ L L GN L +
Sbjct: 33 PGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPA 92
Query: 79 MLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLD 138
LS L L+L QL +LEP A GL++L L L+ N+LR + G F+ AL L
Sbjct: 93 AFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLG 152
Query: 139 LRLNQIVLFLDGAFGELGSLQKLEVG------------------------DNHLVFVAPG 174
L N++ DG F LGSL L +G N L ++ P
Sbjct: 153 LSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPA 212
Query: 175 AFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELE 234
F+GLA+L L L R L + +LP L L L I + GA GL L+ L+
Sbjct: 213 LFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLD 272
Query: 235 I---HLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAI 291
+ + LE PG L+GL + L ++ ++S+ + L FL L L N I +
Sbjct: 273 LSHNRVAGLLEDTFPG-LLGLRV--LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQL 329
Query: 292 PARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLV 351
R L +L+ L L L + A AF GLT +++++ N L+ L E F KL
Sbjct: 330 AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLH 389
Query: 352 TLRLSGNPLTCDCRLLWLLRLRRHLDFGMS 381
+L L G+ L R+R H G+S
Sbjct: 390 SLHLEGSCLG---------RIRPHTFTGLS 410
Score = 137 bits (344), Expect = 4e-32
Identities = 108/301 (35%), Positives = 146/301 (48%), Gaps = 8/301 (2%)
Query: 65 LDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMG 124
L LS NRL L+ G+ L L +L+L +N L+ L AF GL SL L L GNRL +
Sbjct: 151 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQ 210
Query: 125 PGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLST 184
P +FSGL+ L LDL N + F +L LQKL + N + VAPGAF GL L
Sbjct: 211 PALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRW 270
Query: 185 LTLERCNLSTVPGLALARLPALVALRLRELD---IGRLPAGALRGLGQLKELEIHLWPSL 241
L L + V GL P L+ LR+ L I L + L L+EL++ +
Sbjct: 271 LDLSH---NRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLG-HNRI 326
Query: 242 EALDPGSLVGL-NLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLV 300
L S GL L L + L V A L+ + V++LS N + +P + L
Sbjct: 327 RQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLG 386
Query: 301 RLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPL 360
+L L L G+CL I H F GL+ L + DN L +EE + +L+ L L+ N L
Sbjct: 387 KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQL 446
Query: 361 T 361
T
Sbjct: 447 T 447
Score = 94.7 bits (234), Expect = 2e-19
Identities = 101/356 (28%), Positives = 149/356 (41%), Gaps = 63/356 (17%)
Query: 52 EAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLL 111
+ PG L L +L LS N + L+ L L+EL L +N++ L +F GL L
Sbjct: 284 DTFPGLLGL--RVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLE 341
Query: 112 TLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFV 171
L L N+L+ + G F GL+ + +++L N + + F LG L L + + L +
Sbjct: 342 VLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRI 401
Query: 172 APGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLK 231
P F GL+ L L L+ L + +L L L+ L L + LP +GLG+L+
Sbjct: 402 RPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLE 461
Query: 232 ELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAI 291
L ++R L+ +P AL L LD+S N + A+
Sbjct: 462 ------------------------YLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEAL 497
Query: 292 PARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLV 351
P L+PL RL+ L L +N+L+T P P L
Sbjct: 498 PNSLLAPLGRLRYLSL------------------------RNNSLRTFT----PQPPGLE 529
Query: 352 TLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQGKSLKEFSDILPPGH 407
L L GNP C C L L DF + P+ A P VQ ++ E D PP +
Sbjct: 530 RLWLEGNPWDCGCPLKAL------RDFALQNPS-AVPRFVQ--AICEGDDCQPPAY 576
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 140 bits (354), Expect = 3e-33
Identities = 112/331 (33%), Positives = 161/331 (48%), Gaps = 6/331 (1%)
Query: 63 ELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRI 122
E L L N L G+ Q M +L LQEL L+ NQL L F L++L L L GN L
Sbjct: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTH 184
Query: 123 MGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKL 182
+ G+ + L L L N++V G LG+L +L+ NH+ +APGAF L L
Sbjct: 185 LPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNL 244
Query: 183 STLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLE 242
S+LTL R +L+ +P L L L E + LP +G L+EL ++ L
Sbjct: 245 SSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNR-TQLR 303
Query: 243 ALDPGSLVGLN-LSSLAITRC-NLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLV 300
L + L+ L L +T LS++P A L L+VL L N ++A+P L L
Sbjct: 304 TLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLG 363
Query: 301 RLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPL 360
+L+++ L L ++ F L++ + + N L+TL F + +L + L N
Sbjct: 364 KLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSW 423
Query: 361 TCDCRL-LWLLRLRRHLDF--GMSPPACAGP 388
CDC L +L LR+HL G PP CAGP
Sbjct: 424 RCDCGLGPFLGWLRQHLGLVGGEEPPRCAGP 454
Score = 120 bits (302), Expect = 3e-27
Identities = 102/333 (30%), Positives = 149/333 (44%), Gaps = 3/333 (0%)
Query: 31 CPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELD 90
CP C C + A G GLP + + L G LQ S +++LQ L
Sbjct: 21 CPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLM 80
Query: 91 LSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDG 150
+S + +S + PG F L L TLRL N++ + + + L L L N +
Sbjct: 81 ISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQN 140
Query: 151 AFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALR 210
F +L +LQ+L + N L F+ F L L L L NL+ +P L L L
Sbjct: 141 MFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLL 200
Query: 211 LRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGL-NLSSLAITRCNLSSVPF 269
L + L +G L LG L EL+ H + ++ PG+ L NLSSL ++R +L+ +P
Sbjct: 201 LHSNRLVSLDSGLLNSLGALTELQFHR-NHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPS 259
Query: 270 QALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLL 329
H L +L L +NP++ +P + LQEL L+ L ++ A AF L+ L
Sbjct: 260 ALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYL 319
Query: 330 DVA-DNALQTLEETAFPSPDKLVTLRLSGNPLT 361
V L L + AF +L L L N LT
Sbjct: 320 GVTLSPRLSALPQGAFQGLGELQVLALHSNGLT 352
Score = 42.7 bits (99), Expect = 0.001
Identities = 38/121 (31%), Positives = 54/121 (44%), Gaps = 2/121 (1%)
Query: 61 DTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRL 120
+ ++L L N L L G+L L L+++ L N+L L F L SL +++L N+L
Sbjct: 340 ELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQL 399
Query: 121 RIMGPGVFSGLSALTLLDLRLN--QIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAG 178
+ VF L LT + L N + L G L L G+ PGA AG
Sbjct: 400 ETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAG 459
Query: 179 L 179
L
Sbjct: 460 L 460
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 138 bits (348), Expect = 1e-32
Identities = 132/527 (25%), Positives = 219/527 (41%), Gaps = 74/527 (14%)
Query: 31 CPAVCDCTSQP-----------QAVLCGHRQLEAVPGGLPLDTELL-------------- 65
CP +C C +P V C L P LP +T++L
Sbjct: 29 CPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
Query: 66 ---------DLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQ 116
DLS N L + + ++ L + L N+L+ L L +L L +
Sbjct: 89 DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYIN 148
Query: 117 GNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAF 176
N L + PG F GL L L L N++ + F L +L+ L +G+N ++ + F
Sbjct: 149 HNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNF 208
Query: 177 AGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIH 236
L L +L + NL+ +P AL L L ++ + + ++P AL+ + LK L+++
Sbjct: 209 KPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLN 268
Query: 237 LWPSLEALDPGSLVG-LNLSSLAITRC-NLSSVPFQALYHLSFLRVLDLSQNPISAIPAR 294
P + + G L+L L I L S+ A+ +L LR ++ + NP
Sbjct: 269 KNP-INRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNP------- 320
Query: 295 RLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLR 354
L+ I +AF L L + NAL L S L +
Sbjct: 321 ----------------RLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEIS 364
Query: 355 LSGNPLTCDCRLLWLLRLRRHLDFGMSPPA--CAGPHHVQGKSLKE--FSDILPPGHFTC 410
+ NP+ CDC + W+ + ++ F M P + C P QG+++++ F D++ C
Sbjct: 365 IHSNPIRCDCVIRWMNMNKTNIRF-MEPDSLFCVDPPEFQGQNVRQVHFRDMME----IC 419
Query: 411 KPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWL---GRAGRVRVLEDG 467
P + +S P + E G + F C +P P + W+ P G L + V +G
Sbjct: 420 LPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEG 479
Query: 468 TLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPP--NGTLS 512
TL+I V ++ G Y C+ +N+ G D ++V P NG+L+
Sbjct: 480 TLDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLN 526
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 138 bits (348), Expect = 1e-32
Identities = 132/527 (25%), Positives = 219/527 (41%), Gaps = 74/527 (14%)
Query: 31 CPAVCDCTSQP-----------QAVLCGHRQLEAVPGGLPLDTELL-------------- 65
CP +C C +P V C L P LP +T++L
Sbjct: 29 CPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
Query: 66 ---------DLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQ 116
DLS N L + + ++ L + L N+L+ L L +L L +
Sbjct: 89 DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYIN 148
Query: 117 GNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAF 176
N L + PG F GL L L L N++ + F L +L+ L +G+N ++ + F
Sbjct: 149 HNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNF 208
Query: 177 AGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIH 236
L L +L + NL+ +P AL L L ++ + + ++P AL+ + LK L+++
Sbjct: 209 KPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLN 268
Query: 237 LWPSLEALDPGSLVG-LNLSSLAITRC-NLSSVPFQALYHLSFLRVLDLSQNPISAIPAR 294
P + + G L+L L I L S+ A+ +L LR ++ + NP
Sbjct: 269 KNP-INRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNP------- 320
Query: 295 RLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLR 354
L+ I +AF L L + NAL L S L +
Sbjct: 321 ----------------RLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEIS 364
Query: 355 LSGNPLTCDCRLLWLLRLRRHLDFGMSPPA--CAGPHHVQGKSLKE--FSDILPPGHFTC 410
+ NP+ CDC + W+ + ++ F M P + C P QG+++++ F D++ C
Sbjct: 365 IHSNPIRCDCVIRWMNMNKTNIRF-MEPDSLFCVDPPEFQGQNVRQVHFRDMME----IC 419
Query: 411 KPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWL---GRAGRVRVLEDG 467
P + +S P + E G + F C +P P + W+ P G L + V +G
Sbjct: 420 LPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEG 479
Query: 468 TLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPP--NGTLS 512
TL+I V ++ G Y C+ +N+ G D ++V P NG+L+
Sbjct: 480 TLDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLN 526
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 138 bits (348), Expect = 1e-32
Identities = 132/527 (25%), Positives = 219/527 (41%), Gaps = 74/527 (14%)
Query: 31 CPAVCDCTSQP-----------QAVLCGHRQLEAVPGGLPLDTELL-------------- 65
CP +C C +P V C L P LP +T++L
Sbjct: 29 CPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
Query: 66 ---------DLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQ 116
DLS N L + + ++ L + L N+L+ L L +L L +
Sbjct: 89 DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYIN 148
Query: 117 GNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAF 176
N L + PG F GL L L L N++ + F L +L+ L +G+N ++ + F
Sbjct: 149 HNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNF 208
Query: 177 AGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIH 236
L L +L + NL+ +P AL L L ++ + + ++P AL+ + LK L+++
Sbjct: 209 KPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLN 268
Query: 237 LWPSLEALDPGSLVG-LNLSSLAITRC-NLSSVPFQALYHLSFLRVLDLSQNPISAIPAR 294
P + + G L+L L I L S+ A+ +L LR ++ + NP
Sbjct: 269 KNP-INRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNP------- 320
Query: 295 RLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLR 354
L+ I +AF L L + NAL L S L +
Sbjct: 321 ----------------RLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEIS 364
Query: 355 LSGNPLTCDCRLLWLLRLRRHLDFGMSPPA--CAGPHHVQGKSLKE--FSDILPPGHFTC 410
+ NP+ CDC + W+ + ++ F M P + C P QG+++++ F D++ C
Sbjct: 365 IHSNPIRCDCVIRWMNMNKTNIRF-MEPDSLFCVDPPEFQGQNVRQVHFRDMME----IC 419
Query: 411 KPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWL---GRAGRVRVLEDG 467
P + +S P + E G + F C +P P + W+ P G L + V +G
Sbjct: 420 LPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEG 479
Query: 468 TLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPP--NGTLS 512
TL+I V ++ G Y C+ +N+ G D ++V P NG+L+
Sbjct: 480 TLDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLN 526
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 136 bits (343), Expect = 5e-32
Identities = 122/400 (30%), Positives = 179/400 (44%), Gaps = 42/400 (10%)
Query: 31 CPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQ-GMLSRLSLLQEL 89
CP C C + V C +L +P +P T L L+ N + L+ GM +L+ L+++
Sbjct: 513 CPHKCRC--EANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKI 570
Query: 90 DLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLD 149
+LS N++S +E GAF G S+ L L N+L + G+F GL L L LR N+I +
Sbjct: 571 NLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHN 630
Query: 150 GAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLE------RCNLSTVPGLALARL 203
+F L +++ L + DN + V+PGAF L LSTL L C L+ + G R
Sbjct: 631 DSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRK 690
Query: 204 PALVALRLRELDI------------------GRLPAGAL------RGLGQLKELEIHLWP 239
R + D G+ G L + L +
Sbjct: 691 IVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSNK 750
Query: 240 SLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPL 299
L AL G + N++ L + + VP Q L +L+++DLS N IS++ + +
Sbjct: 751 HLRALPKG--IPKNVTELYLDGNQFTLVPGQ-LSTFKYLQLVDLSNNKISSLSNSSFTNM 807
Query: 300 VRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNP 359
+L L LS L I AF GL + LL + N + TL+E F L L + NP
Sbjct: 808 SQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANP 867
Query: 360 LTCDCRLLWLLRLRRHLDFGMSPPA---CAGPHHVQGKSL 396
L CDC L W L + G P CAGP ++GK L
Sbjct: 868 LYCDCHLRW---LSSWVKTGYKEPGIARCAGPQDMEGKLL 904
Score = 133 bits (334), Expect = 5e-31
Identities = 131/467 (28%), Positives = 186/467 (39%), Gaps = 85/467 (18%)
Query: 13 PWPPLLFLLLLPGG---SGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSG 69
P P L+LLL +CPA+C CT V C L+A+P +P +TE L+L+G
Sbjct: 13 PVRPELWLLLWAAAWRLGASACPALCTCTGT--TVDCHGTGLQAIPKNIPRNTERLELNG 70
Query: 70 NRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFS 129
N + + + + L L+ L L NQ+ +E GAF ++ L LRL N+L ++ +F
Sbjct: 71 NNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQ 130
Query: 130 GLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLER 189
AL+ LDL N I AF L+ L++ N + + GAF L L LTL
Sbjct: 131 NNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNN 190
Query: 190 CNLSTVPGLALARLPALVALRL-------------------RELDIGRLP----AGALRG 226
N++T+P + +P L RL + IG +LRG
Sbjct: 191 NNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRG 250
Query: 227 L--GQLKELEIHLWPSLEA-------LDPGSLVGLNLSSLAITRC--------------- 262
L ++++ E EA L GS + S I C
Sbjct: 251 LNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPET 310
Query: 263 ---------NLSSVPFQALYHLSFLRVLDLSQNPISAIP------ARRLSPLV------- 300
+ S+P A LR +DLS N I+ I R L+ LV
Sbjct: 311 MTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKIT 370
Query: 301 -----------RLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDK 349
LQ L L+ + I AF L LL + DN +Q+L + F S
Sbjct: 371 DLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRA 430
Query: 350 LVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQGKSL 396
+ TL L+ NP CDC L WL R S CA P + K +
Sbjct: 431 IQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRI 477
Score = 121 bits (303), Expect = 2e-27
Identities = 113/436 (25%), Positives = 175/436 (40%), Gaps = 66/436 (15%)
Query: 27 SGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLL 86
S GSCPA+C C++ V C + L A+P LP + L N + + G S L
Sbjct: 278 SSGSCPAMCTCSNG--IVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKL 335
Query: 87 QELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVL 146
+ +DLS NQ++ + P AF GL+SL +L L GN++ + GVF GL L LL L N+I
Sbjct: 336 RRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINC 395
Query: 147 FLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLER------CNLSTVPG--- 197
AF +L +L L + DN + +A G F L + TL L + CNL +
Sbjct: 396 IRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLR 455
Query: 198 ---LALARLPALVALRLRELDIGRLPAGALRGLGQLK----------------------- 231
+ + RL IG++ + R + +
Sbjct: 456 TNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPH 515
Query: 232 ----ELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALY-HLSFLRVLDLSQN 286
E + SL+ + + + L + +S + ++ L+ L+ ++LS N
Sbjct: 516 KCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNN 575
Query: 287 PISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAF-------------------- 326
+S I + EL L+ L SI + F GL
Sbjct: 576 KVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTG 635
Query: 327 ----HLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMSP 382
LL + DN + T+ AF + L TL L NP C+C+L WL R
Sbjct: 636 LRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGN 695
Query: 383 PACAGPHHVQGKSLKE 398
P C P ++ L++
Sbjct: 696 PRCQNPDFLRQIPLQD 711
Score = 75.1 bits (183), Expect = 2e-13
Identities = 58/192 (30%), Positives = 93/192 (48%), Gaps = 4/192 (2%)
Query: 209 LRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLN-LSSLAITRCNLSSV 267
L L +I R+ GL QL+ L++ + + A++ G+ + L L + R L +
Sbjct: 66 LELNGNNITRIHKNDFAGLKQLRVLQL-MENQIGAVERGAFDDMKELERLRLNRNQLHML 124
Query: 268 PFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFH 327
P + L LDLS+N I AIP + L+ L+L ++ I AF L
Sbjct: 125 PELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLE 184
Query: 328 LLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLR-LRRHLDFGMSPPACA 386
+L + +N + T+ ++F KL T RL N L CDC L WL + LR+ G+ C+
Sbjct: 185 VLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLF-TQCS 243
Query: 387 GPHHVQGKSLKE 398
GP ++G ++ E
Sbjct: 244 GPASLRGLNVAE 255
>gi|13375646 leucine rich repeat and fibronectin type III domain
containing 3 [Homo sapiens]
Length = 628
Score = 136 bits (342), Expect = 6e-32
Identities = 113/362 (31%), Positives = 156/362 (43%), Gaps = 32/362 (8%)
Query: 160 KLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRL 219
+L + DN + V A + L L+L R + V A A L AL AL L + L
Sbjct: 63 ELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSL 122
Query: 220 PAGALRGLGQLKELEIHLWPSLEALDPGSL--VGLNLSSLAITRCNLSSVPFQALYHLSF 277
G LRGL L+ L + L AL G+L L L ++ NL +P++AL L
Sbjct: 123 GEGQLRGLVNLRHLILSN-NQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGN 181
Query: 278 LRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQ 337
+ L L N ++++PA S L +L L ++ LT+I D
Sbjct: 182 VNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPP---------------DPLFS 226
Query: 338 TLEETAFP--SPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQGKS 395
L A P SP + L GNPL C+C L+WL RL R D ACA P + G+
Sbjct: 227 RLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLAREDDL----EACASPPALGGRY 282
Query: 396 LKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWL 455
+ F C+P ++ P + G A C GDP P V W+ P G L
Sbjct: 283 FWAVGE----EEFVCEPPVVTHRSPPLAVPA-GRPAALRCRAVGDPEPRVRWVSPQGRLL 337
Query: 456 GRAGRVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPP---NGTLS 512
G + R R +GTLE+ + D G + C+ +N AG + L V PP N T
Sbjct: 338 GNSSRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPPPPQLANSTSC 397
Query: 513 DP 514
DP
Sbjct: 398 DP 399
Score = 79.7 bits (195), Expect = 7e-15
Identities = 69/219 (31%), Positives = 101/219 (46%), Gaps = 12/219 (5%)
Query: 18 LFLLLLPGGSGGS---------CPAVCDCTSQ--PQAVLCGHRQLEAVPGGLPLDTELLD 66
L L LLP S CP C C +Q P +VLC L VP L L
Sbjct: 6 LLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELR 65
Query: 67 LSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPG 126
L+ N + +++ L+ ++ L L LS N + + GAF L++L L L GNRL +G G
Sbjct: 66 LADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEG 125
Query: 127 VFSGLSALTLLDLRLNQIVLFLDGAFGELG-SLQKLEVGDNHLVFVAPGAFAGLAKLSTL 185
GL L L L NQ+ GA + +L+ L++ N+L + A L ++TL
Sbjct: 126 QLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTL 185
Query: 186 TLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGAL 224
L+ L++VP A +RL L L + + +P L
Sbjct: 186 GLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPL 224
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 135 bits (340), Expect = 1e-31
Identities = 143/458 (31%), Positives = 218/458 (47%), Gaps = 42/458 (9%)
Query: 63 ELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQS-LLTLRLQGNRLR 121
E LDLS N + ++ R+ L + L+LS N+++TLE G F L S LL ++L NR+
Sbjct: 147 ESLDLSSNIISEIKTSSFPRMQL-KYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMS 205
Query: 122 IMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAK 181
++ P +F L L L+L+ N+I + F L SL+ L++ N + + GAF GL
Sbjct: 206 MIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNN 264
Query: 182 LSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSL 241
+ L LE NL+ V L L L L + + I R+ A +L EL++ + L
Sbjct: 265 MEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLS-YNQL 323
Query: 242 EALDPGSLVGLNL-SSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPIS-AIP--ARRLS 297
LD + VGL+L L + ++ + LS L+ LDL N IS AI + +
Sbjct: 324 TRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFA 383
Query: 298 PLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSG 357
L L +L L G + SI AF GL + LD+ +NA+ +++E AF S L L L+
Sbjct: 384 GLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAF-SQTHLKELILNT 442
Query: 358 NPLTCDCRLLWLLRLRRHLDFGMS-PPACAGPHHVQGKS-----LKEF--SDILPPGHFT 409
+ L CDC L WLL+ +F S +CA P + G+S LK+F D L
Sbjct: 443 SSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFL------ 496
Query: 410 CKPALIRKSGPRWVIAEEGGHAVFSC---SGDGDPAPTVSWMRPHG-----------AWL 455
KP + ++ P +IA G + +C S P TV W + +
Sbjct: 497 -KPQI--RTHPETIIALRGMNVTLTCTAVSSSDSPMSTV-WRKDSEILYDVDTENFVRYW 552
Query: 456 GRAGRVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGND 493
+AG + L + +V D G Y C+V+N G++
Sbjct: 553 QQAGEA-LEYTSILHLFNVNFTDEGKYQCIVTNHFGSN 589
Score = 107 bits (268), Expect = 2e-23
Identities = 106/349 (30%), Positives = 158/349 (45%), Gaps = 15/349 (4%)
Query: 20 LLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQL-----EAVPGGLPLDTELLDLSGNRLWG 74
LLLLP G CPA C C + + C R+L A+ G LP DT +LD S NRL
Sbjct: 32 LLLLPAAGAGLCPAPCSC--RIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLSN 89
Query: 75 LQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSAL 134
+ S+ LQE+ ++YN+L+ + P ++ L L N + + AL
Sbjct: 90 WNISLESQT--LQEVKMNYNELTEI-PYFGEPTSNITLLSLVHNIIPEINAQALQFYPAL 146
Query: 135 TLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAK-LSTLTLERCNLS 193
LDL N I +F + L+ L + +N + + G F L+ L + L R +S
Sbjct: 147 ESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMS 205
Query: 194 TVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLN 253
+P + +LP L L L+ I + +GL L+ L++ + L G+ GLN
Sbjct: 206 MIPP-KIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQR-NGISKLKDGAFFGLN 263
Query: 254 -LSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACL 312
+ L + NL+ V LY L L+ L +SQN I I RL EL LS L
Sbjct: 264 NMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQL 323
Query: 313 TSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLT 361
T + AF GL+ L++ DN + + + F L TL L N ++
Sbjct: 324 TRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEIS 372
Score = 50.1 bits (118), Expect = 6e-06
Identities = 30/93 (32%), Positives = 43/93 (46%), Gaps = 3/93 (3%)
Query: 428 GGHAVFSCSGDGDPAPTVSWMRPHGAWL--GRAGRVRVL-EDGTLEIRSVQLRDRGAYVC 484
G A C+ +G PAP +SW + G R R+ V+ ED I +V++ D G Y C
Sbjct: 616 GAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSC 675
Query: 485 VVSNVAGNDSLRTWLEVIQVEPPNGTLSDPNIT 517
+ N AG S L V++ L D +T
Sbjct: 676 MAQNTAGGLSANASLTVLETPSFIRPLEDKTVT 708
Score = 44.7 bits (104), Expect = 2e-04
Identities = 32/105 (30%), Positives = 43/105 (40%), Gaps = 4/105 (3%)
Query: 412 PALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWLGRAGRVRVLEDGTLEI 471
P+ IR + V G AV C G PAP ++W + G L + L I
Sbjct: 696 PSFIRPLEDKTVT--RGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLII 753
Query: 472 RSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPPNGTLSDPNI 516
L D G Y C++SN G + +L VI PN S +I
Sbjct: 754 VDAGLEDAGKYTCIMSNTLGTERGHIYLNVI--SSPNCDSSQSSI 796
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 133 bits (335), Expect = 4e-31
Identities = 117/374 (31%), Positives = 173/374 (46%), Gaps = 34/374 (9%)
Query: 19 FLLLLPG----GSG---GSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNR 71
+LLLL G G+G CP+ C C+ Q V C ++ AVP LP + L +
Sbjct: 12 YLLLLVGCQAWGAGLAYHGCPSECTCSRASQ-VECTGARIVAVPTPLPWNAMSLQILNTH 70
Query: 72 LWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGL 131
+ L + +S L L + N+LS + PGAF L SL L L N+L+++ G+F GL
Sbjct: 71 ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGL 130
Query: 132 SALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCN 191
+L L L NQ++ F + +L++L++ NHL ++ GAF L L+ L L + +
Sbjct: 131 DSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNS 190
Query: 192 LSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSL-V 250
L+ + L L LRL E + +P G GL L+EL + + L PG
Sbjct: 191 LTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQ-QNQIGLLSPGLFHN 249
Query: 251 GLNLSSLAITRCNLSSVP---FQALYHLS---------------------FLRVLDLSQN 286
NL L ++ ++S +P F L L+ LR L L N
Sbjct: 250 NHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 309
Query: 287 PISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPS 346
IS++P S L +LQ L LS ++ I+ AF+GLT L + NALQ L+ F
Sbjct: 310 HISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRM 369
Query: 347 PDKLVTLRLSGNPL 360
L + L N L
Sbjct: 370 LANLQNISLQNNRL 383
Score = 80.1 bits (196), Expect = 5e-15
Identities = 63/222 (28%), Positives = 93/222 (41%), Gaps = 48/222 (21%)
Query: 63 ELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRI 122
++L L NRL + G L LQEL L NQ+ L PG FH +L L L N +
Sbjct: 206 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ 265
Query: 123 MGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLV------------- 169
+ P +F L L L L N + G FG + +L++L + DNH+
Sbjct: 266 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQL 325
Query: 170 -----------FVAPGAFAG------------------------LAKLSTLTLERCNLST 194
F++PGAF G LA L ++L+ L
Sbjct: 326 QVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQ 385
Query: 195 VPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIH 236
+PG A + L+A++L+ + LP G LG+L EL ++
Sbjct: 386 LPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLY 427
Score = 57.0 bits (136), Expect = 5e-08
Identities = 35/104 (33%), Positives = 56/104 (53%)
Query: 63 ELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRI 122
++L LS N++ + G + L+ L+EL L N L L+ F L +L + LQ NRLR
Sbjct: 326 QVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQ 385
Query: 123 MGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDN 166
+ +F+ ++ L + L+ NQ+ G F LG L +L + DN
Sbjct: 386 LPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 429
Score = 49.3 bits (116), Expect = 1e-05
Identities = 44/159 (27%), Positives = 62/159 (38%), Gaps = 24/159 (15%)
Query: 203 LPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLNLSSLAITRC 262
+ AL+ALR+ + ++ R+ GA R LG L+ L ++
Sbjct: 82 ISALIALRIEKNELSRITPGAFRNLGSLRYL------------------------SLANN 117
Query: 263 NLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHG 322
L +P L L L LS N + I S L+EL+L G L I AF
Sbjct: 118 KLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDH 177
Query: 323 LTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLT 361
L L++ N+L + F L LRL N LT
Sbjct: 178 LVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLT 216
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 133 bits (335), Expect = 4e-31
Identities = 117/374 (31%), Positives = 173/374 (46%), Gaps = 34/374 (9%)
Query: 19 FLLLLPG----GSG---GSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNR 71
+LLLL G G+G CP+ C C+ Q V C ++ AVP LP + L +
Sbjct: 6 YLLLLVGCQAWGAGLAYHGCPSECTCSRASQ-VECTGARIVAVPTPLPWNAMSLQILNTH 64
Query: 72 LWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGL 131
+ L + +S L L + N+LS + PGAF L SL L L N+L+++ G+F GL
Sbjct: 65 ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGL 124
Query: 132 SALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCN 191
+L L L NQ++ F + +L++L++ NHL ++ GAF L L+ L L + +
Sbjct: 125 DSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNS 184
Query: 192 LSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSL-V 250
L+ + L L LRL E + +P G GL L+EL + + L PG
Sbjct: 185 LTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQ-QNQIGLLSPGLFHN 243
Query: 251 GLNLSSLAITRCNLSSVP---FQALYHLS---------------------FLRVLDLSQN 286
NL L ++ ++S +P F L L+ LR L L N
Sbjct: 244 NHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 303
Query: 287 PISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPS 346
IS++P S L +LQ L LS ++ I+ AF+GLT L + NALQ L+ F
Sbjct: 304 HISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRM 363
Query: 347 PDKLVTLRLSGNPL 360
L + L N L
Sbjct: 364 LANLQNISLQNNRL 377
Score = 80.1 bits (196), Expect = 5e-15
Identities = 63/222 (28%), Positives = 93/222 (41%), Gaps = 48/222 (21%)
Query: 63 ELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRI 122
++L L NRL + G L LQEL L NQ+ L PG FH +L L L N +
Sbjct: 200 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ 259
Query: 123 MGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLV------------- 169
+ P +F L L L L N + G FG + +L++L + DNH+
Sbjct: 260 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQL 319
Query: 170 -----------FVAPGAFAG------------------------LAKLSTLTLERCNLST 194
F++PGAF G LA L ++L+ L
Sbjct: 320 QVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQ 379
Query: 195 VPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIH 236
+PG A + L+A++L+ + LP G LG+L EL ++
Sbjct: 380 LPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLY 421
Score = 57.0 bits (136), Expect = 5e-08
Identities = 35/104 (33%), Positives = 56/104 (53%)
Query: 63 ELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRI 122
++L LS N++ + G + L+ L+EL L N L L+ F L +L + LQ NRLR
Sbjct: 320 QVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQ 379
Query: 123 MGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDN 166
+ +F+ ++ L + L+ NQ+ G F LG L +L + DN
Sbjct: 380 LPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
Score = 49.3 bits (116), Expect = 1e-05
Identities = 44/159 (27%), Positives = 62/159 (38%), Gaps = 24/159 (15%)
Query: 203 LPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLNLSSLAITRC 262
+ AL+ALR+ + ++ R+ GA R LG L+ L ++
Sbjct: 76 ISALIALRIEKNELSRITPGAFRNLGSLRYL------------------------SLANN 111
Query: 263 NLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHG 322
L +P L L L LS N + I S L+EL+L G L I AF
Sbjct: 112 KLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDH 171
Query: 323 LTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLT 361
L L++ N+L + F L LRL N LT
Sbjct: 172 LVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLT 210
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 130 bits (327), Expect = 3e-30
Identities = 119/402 (29%), Positives = 161/402 (40%), Gaps = 65/402 (16%)
Query: 15 PPLLFLLLLPGGSGGS--CPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRL 72
P L+ LLL P + CP C C + + V C ++ L VP +P T+ LDL GN L
Sbjct: 15 PLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLL 74
Query: 73 WGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLS 132
+ + L LDL + ++ + GAF GL LL L L N LR + GL
Sbjct: 75 KVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLG 134
Query: 133 ALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNL 192
+L L+L N + G FG LG+L L + N LV++ AF GL ++ L L L
Sbjct: 135 SLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNAL 194
Query: 193 STVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGL 252
S + ALA LPAL L L ++ LP L L LE+ P A + L
Sbjct: 195 SVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALP 254
Query: 253 NLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACL 312
L L + L ++ +A H L LDL N + +P L +L+ LRL G
Sbjct: 255 GLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQG--- 309
Query: 313 TSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCR----LLW 368
NPL C C+ L W
Sbjct: 310 ---------------------------------------------NPLWCGCQARPLLEW 324
Query: 369 LLRLRRHLDFGMSPPACAGPHHVQGKSLKEFSDILPPGHFTC 410
L R R D AC GP ++G++L D L P C
Sbjct: 325 LARARVRSD-----GACQGPRRLRGEAL----DALRPWDLRC 357
Score = 116 bits (291), Expect = 5e-26
Identities = 117/373 (31%), Positives = 156/373 (41%), Gaps = 61/373 (16%)
Query: 31 CPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELD 90
CP C C + + C L+AVP G P DT+LLDL N
Sbjct: 396 CPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHF------------------ 437
Query: 91 LSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDG 150
++ AF GL L++L LQ G++ L G
Sbjct: 438 ------PSVPRAAFPGLGHLVSLHLQ-----------HCGIAELEA-------------G 467
Query: 151 AFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALR 210
A LG L L + DN L ++ A G +L L LER VPG AL LP+L +L
Sbjct: 468 ALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLH 527
Query: 211 LRELDIGRLPAGALRGLGQLKELEIH----LWPSLEALDPGSLVGLNLSSLAITRCNLSS 266
L++ + RL G L L+ + + SL AL P L L + R L
Sbjct: 528 LQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPAR----ELEKLHLDRNQLRE 583
Query: 267 VPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVR-LQELRLSGACLTSIAAHAFHGL-T 324
VP AL L L L LS NP+ A+ P+ R LQ L L+ + L I AF GL
Sbjct: 584 VPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGP 643
Query: 325 AFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPA 384
L + N L+ L A PS +L + LS NP CDC+LL L R L+ +
Sbjct: 644 GLQSLHLQKNQLRALP--ALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRVG-AT 700
Query: 385 CAGPHHVQGKSLK 397
CA P + +G+ +K
Sbjct: 701 CATPPNARGQRVK 713
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 127 bits (320), Expect = 2e-29
Identities = 125/379 (32%), Positives = 158/379 (41%), Gaps = 51/379 (13%)
Query: 21 LLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVP--GGLPLDTELL--DLSGNRLWGLQ 76
L LP + CP CDC PQ +LC +R L VP LP ++L L GN + +
Sbjct: 17 LALPPLAEPVCPERCDC-QHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNIT 75
Query: 77 QGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGV--------- 127
RL L+ LDL YNQ+ +L P F L L L L N L+ + PG
Sbjct: 76 AFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRI 135
Query: 128 ---------------FSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVA 172
F GL +L L L N + D F LG+L L + N + F+
Sbjct: 136 LYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLG 195
Query: 173 PGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKE 232
AFA L KL L L L P L A A LR L L A L+ LG
Sbjct: 196 KNAFAQLGKLRFLNLSANELQ--PSLRHAATFA----PLRSLSSLILSANNLQHLGP--- 246
Query: 233 LEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIP 292
++ L L SL G L+ LA +A + L LR L L N +S +P
Sbjct: 247 ---RIFQHLPRLGLLSLRGNQLTHLAP----------EAFWGLEALRELRLEGNRLSQLP 293
Query: 293 ARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVT 352
L PL L+ L LSG L+++ F L L + +NAL L F + L
Sbjct: 294 TALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYR 353
Query: 353 LRLSGNPLTCDCRLLWLLR 371
L L GN TCDCRL L R
Sbjct: 354 LDLDGNGWTCDCRLRGLKR 372
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 127 bits (318), Expect = 4e-29
Identities = 106/356 (29%), Positives = 148/356 (41%), Gaps = 44/356 (12%)
Query: 160 KLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRL 219
+L + DN + + FA + L LTL R +S + A A L L AL L + ++
Sbjct: 55 ELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKI 114
Query: 220 PAGALRGLGQLKELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLR 279
GL L L LN + L + +SS F ++ L
Sbjct: 115 TNDMFSGLSNLHHLI-----------------LNNNQLTL----ISSTAFDDVFALE--- 150
Query: 280 VLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTL 339
LDLS N + IP + +V L L L + +I F L LDV N LQ L
Sbjct: 151 ELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKL 210
Query: 340 E-ETAFPSPDKLVT----------LRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGP 388
+ F L T L GNPL C+C LLWL RL R D CA P
Sbjct: 211 PPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSREDDL----ETCASP 266
Query: 389 HHVQGKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWM 448
+ G+ +P F C+P LI + + E G A C GDP P + W+
Sbjct: 267 PLLTGRYFWS----IPEEEFLCEPPLITRHTHEMRVLE-GQRATLRCKARGDPEPAIHWI 321
Query: 449 RPHGAWLGRAGRVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQV 504
P G + A R V ++GTL+I ++D GA+ C+ SN AG + L +I++
Sbjct: 322 SPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKL 377
Score = 84.0 bits (206), Expect = 4e-16
Identities = 70/235 (29%), Positives = 112/235 (47%), Gaps = 4/235 (1%)
Query: 17 LLFLLLLPGGSGGS--CP--AVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRL 72
+LF L L G + + CP VC S A LC + L VP + T L L+ N +
Sbjct: 4 ILFYLFLIGIAVKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFV 63
Query: 73 WGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLS 132
+++ + ++ L +L LS N +S + P AF L++L L L NRL + +FSGLS
Sbjct: 64 TNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLS 123
Query: 133 ALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNL 192
L L L NQ+ L AF ++ +L++L++ N+L + A + L TL+L+ +
Sbjct: 124 NLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMI 183
Query: 193 STVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPG 247
+P + L + L + + +LP L Q+ + PS AL G
Sbjct: 184 DNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFG 238
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.140 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,547,338
Number of Sequences: 37866
Number of extensions: 1245443
Number of successful extensions: 7547
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 302
Number of HSP's successfully gapped in prelim test: 185
Number of HSP's that attempted gapping in prelim test: 3197
Number of HSP's gapped (non-prelim): 2305
length of query: 593
length of database: 18,247,518
effective HSP length: 108
effective length of query: 485
effective length of database: 14,157,990
effective search space: 6866625150
effective search space used: 6866625150
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.