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Search of human proteins with 51988887
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
(888 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 1783 0.0
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 718 0.0
gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 370 e-102
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 140 5e-33
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 140 5e-33
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 97 9e-20
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 96 2e-19
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 96 2e-19
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 96 2e-19
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 96 2e-19
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 96 2e-19
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 96 2e-19
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 93 1e-18
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 93 1e-18
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 86 1e-16
gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens] 82 2e-15
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 82 3e-15
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 82 3e-15
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 82 3e-15
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 82 3e-15
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 82 3e-15
gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens] 79 1e-14
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 79 2e-14
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 79 2e-14
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 79 2e-14
gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens] 75 3e-13
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 70 7e-12
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 70 7e-12
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 70 7e-12
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 64 5e-10
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 1783 bits (4618), Expect = 0.0
Identities = 888/888 (100%), Positives = 888/888 (100%)
Query: 1 MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGV 60
MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGV
Sbjct: 1 MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGV 60
Query: 61 EELPSNILLVRLLDGIKQRPWKPGPGGGSGTNCTNALRSQSSTVANCSSKDLQSSQGGQQ 120
EELPSNILLVRLLDGIKQRPWKPGPGGGSGTNCTNALRSQSSTVANCSSKDLQSSQGGQQ
Sbjct: 61 EELPSNILLVRLLDGIKQRPWKPGPGGGSGTNCTNALRSQSSTVANCSSKDLQSSQGGQQ 120
Query: 121 PRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIH 180
PRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIH
Sbjct: 121 PRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIH 180
Query: 181 GFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEG 240
GFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEG
Sbjct: 181 GFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEG 240
Query: 241 MLADKIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKKNTK 300
MLADKIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKKNTK
Sbjct: 241 MLADKIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKKNTK 300
Query: 301 KRHSFTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQVHIS 360
KRHSFTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQVHIS
Sbjct: 301 KRHSFTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQVHIS 360
Query: 361 TTGLIVTPPPSSPVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVLASTPPGATAA 420
TTGLIVTPPPSSPVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVLASTPPGATAA
Sbjct: 361 TTGLIVTPPPSSPVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVLASTPPGATAA 420
Query: 421 AAAAGMGPRPMAGSTDQIAHLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQD 480
AAAAGMGPRPMAGSTDQIAHLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQD
Sbjct: 421 AAAAGMGPRPMAGSTDQIAHLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQD 480
Query: 481 GWFKGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPA 540
GWFKGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPA
Sbjct: 481 GWFKGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPA 540
Query: 541 QKLQGNGVAGSPSVVPAAVVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQER 600
QKLQGNGVAGSPSVVPAAVVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQER
Sbjct: 541 QKLQGNGVAGSPSVVPAAVVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQER 600
Query: 601 PTAAVTPIQVQNAAGLSPASVGLSHHSLASPQPAPLMPGSATHTAAISISRASAPLACAA 660
PTAAVTPIQVQNAAGLSPASVGLSHHSLASPQPAPLMPGSATHTAAISISRASAPLACAA
Sbjct: 601 PTAAVTPIQVQNAAGLSPASVGLSHHSLASPQPAPLMPGSATHTAAISISRASAPLACAA 660
Query: 661 AAPLTSPSITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSATKPDKDSKKEKKGLL 720
AAPLTSPSITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSATKPDKDSKKEKKGLL
Sbjct: 661 AAPLTSPSITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSATKPDKDSKKEKKGLL 720
Query: 721 KLLSGASTKRKPRVSPPASPTLEVELGSAELPLQGAVGPELPPGGGHGRAGSCPVDGDGP 780
KLLSGASTKRKPRVSPPASPTLEVELGSAELPLQGAVGPELPPGGGHGRAGSCPVDGDGP
Sbjct: 721 KLLSGASTKRKPRVSPPASPTLEVELGSAELPLQGAVGPELPPGGGHGRAGSCPVDGDGP 780
Query: 781 VTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSY 840
VTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSY
Sbjct: 781 VTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSY 840
Query: 841 PPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
PPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI
Sbjct: 841 PPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 718 bits (1853), Expect = 0.0
Identities = 440/930 (47%), Positives = 543/930 (58%), Gaps = 137/930 (14%)
Query: 1 MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGV 60
MDES+LLDLLEC VCLERLD +AKVLPCQHTFC+RCL IV SR+ELRCPECR LVG GV
Sbjct: 46 MDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGV 105
Query: 61 EELPSNILLVRLLDGIKQRPWKPGPGGGS-------GTNCTNALRSQSSTVANCS----- 108
+ELP+NILLVRLLDGI+QRP GGS G + L A +
Sbjct: 106 DELPANILLVRLLDGIRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPV 165
Query: 109 --SKDLQSSQGGQQPRVQSWSPPVRGIP-QLPCAKALYNYEGKEPGDLKFSKGDIIILRR 165
S S+ G + S + P P LP KALY+YEGKEPGDLKF+KGDII+LRR
Sbjct: 166 FLSAAAGSTAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRR 225
Query: 166 QVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDD 225
+VDE WYHGE++G GF P +++Q I+PLP PPQ KALYDFE+KDK+ DKDCL F KD+
Sbjct: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDE 285
Query: 226 VLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKP---PVPGVDAGECSSA 282
+LTV+RRVDENWAEGML DKIGIFP+ YVE N +AKQLIE DKP +A S +
Sbjct: 286 ILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDS 345
Query: 283 AAQSSTAP--------------KHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISP 328
A +S AP + D KKNTKKRHSFT+L++ ++SSQA+ +RHSMEIS
Sbjct: 346 GAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISA 405
Query: 329 PVLISSSNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPSDVPY 388
PVLISSS+P AAARI +L+ LSC+A P+ V++
Sbjct: 406 PVLISSSDPRAAARIGDLAHLSCAA----------------PTQDVSSSAG--------- 440
Query: 389 QAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPS 448
STP AA+ +G P + Q +
Sbjct: 441 -----------------------STPTAVPRAASVSGEQGTPP----------KVQLPLN 467
Query: 449 VYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAV 508
VY+A+Y Y P+K DELEL KGEM+ V E+CQDGWFKG S+ T GVFPGNYV PV+R
Sbjct: 468 VYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSR-- 525
Query: 509 TNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNGVAGSPSVV--PAAVVS----- 561
VP AG V SP G G+G S + PA ++
Sbjct: 526 -------VPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAH 578
Query: 562 AAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVA---AHNQERPTAAVTPIQVQNAAGLSP 618
A H SP L + Q T +QAR+ + T A A Q+RPTA V+P++ QN+ P
Sbjct: 579 AQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLP 638
Query: 619 ASVGLSHHSLASPQPAPLMPGSATHTAAISISRASAPLACAAAAPLTSPSITSASLEAEP 678
A+ L HS+ SPQ + P AI PL AA+A +T P++++A+L E
Sbjct: 639 AT-SLRPHSVVSPQHSHQPPVQMCPRPAI-------PLTSAASA-ITPPNVSAANLNGEA 689
Query: 679 SGRIVTVLPGLPTSPDSASSACGNSSATKPDKDSKKEKK-GLLKLLSGASTKRKPRVSPP 737
G + VL S SS K KKEKK GLLKLL+GASTK+K R P
Sbjct: 690 GGGPIGVL--------STSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKKKSRSPPS 741
Query: 738 ASPTLEVELGSAELPLQGAVGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHR 797
SPT + ++ L LQGAVGPE+ HGRAGSCP++ + A+ + HR
Sbjct: 742 VSPTHDPQVAVDAL-LQGAVGPEVSSLSIHGRAGSCPIESE-------MQGAMGMEPLHR 793
Query: 798 KASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVF 857
KA SLD + P RQA S+ + E + + ER+RVVVSYPPQSEAE+ELKEGDIVF
Sbjct: 794 KAGSLD--LNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVF 851
Query: 858 VHKKREDGWFKGTLQRNGKTGLFPGSFVEN 887
VHKKREDGW+KGTLQRNG+TGLFPGSFVE+
Sbjct: 852 VHKKREDGWYKGTLQRNGRTGLFPGSFVES 881
>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
Length = 729
Score = 370 bits (950), Expect = e-102
Identities = 270/815 (33%), Positives = 386/815 (47%), Gaps = 103/815 (12%)
Query: 1 MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGV 60
MD+ LLDLLECPVC E+LD +AKVLPCQHTFCK CL + + ELRCPECRT V S +
Sbjct: 1 MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRVFKAHKELRCPECRTPVFSNI 60
Query: 61 EELPSNILLVRLLDGIKQRPWKPGPGGGSGTNCTNALRSQSSTVANCSSKDLQSSQGGQQ 120
E LP+N+LLVRLLDG++ G G + Q + + + LQ+S
Sbjct: 61 EALPANLLLVRLLDGVRSGQ---SSGRGGSFRRPGTMTLQDGRKSRTNPRRLQASPFRLV 117
Query: 121 PRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIH 180
P V+ + G+P+ AKAL NY G+ PGDL+F+KGDII+LRRQ+DENWY GE+NGI
Sbjct: 118 PNVRIH---MDGVPR---AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGIS 171
Query: 181 GFFPTNFVQIIKPLPQPPPQCKALYDFEV--KDKEADKDCLPFAKDDVLTVIRRVDENWA 238
G FP + V++IK LPQPPP C+ALY+F++ KDK ++DCL F KDD++TVI RVDENWA
Sbjct: 172 GNFPASSVEVIKQLPQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWA 231
Query: 239 EGMLADKIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAG---ECSSAAAQSSTAPKHSDT 295
EG L DK+GIFPI +VE N A+ L+E +K SS+ +ST + +
Sbjct: 232 EGKLGDKVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGS 291
Query: 296 KKNTKKRHSF-TSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAP 354
++ + S T+L N+ + RH +EIS PVLISSSNP+
Sbjct: 292 RRKVPGQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPS---------------- 335
Query: 355 SQVHISTTGLIVTPPPSSPVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVLASTP 414
++T P +DVP + +G ++ P P
Sbjct: 336 ----------VITQPMEK-----------ADVP-SSCVGQVSTYHPAP----------VS 363
Query: 415 PGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLV 474
PG + A + + GS ++ +++VA++ Y+ DEL+L+KGE V
Sbjct: 364 PGHSTAVVS-------LPGSQQHLS-------ANMFVALHSYSAHGPDELDLQKGEGVRV 409
Query: 475 FERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVP--MSTAGQTSRGVTMVS 532
+CQDGW +G S+ T ++G+FP NYV P+ R ++ ++ P +T ++ V+
Sbjct: 410 LGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKTSSFPDSRSPGLYTTWTLSTSSVSSQG 469
Query: 533 PSTAGGPAQKLQGNGVAGSPSVVPAAVVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRT 592
+ G P Q V VP A+V+ P GQ ++ + R+++R
Sbjct: 470 SISEGDPRQSRPFKSV-----FVPTAIVNPVRSTAGPGT------LGQGSLRKGRSSMRK 518
Query: 593 VAAHNQERPTAAVTPIQVQNAAGLSPASV-GLSHHSLASPQPAPLMPGSATHTAAISISR 651
+ +RP + P V + SP V PQ P P + +
Sbjct: 519 NG--SLQRPLQSGIPTLVVGSLRRSPTMVLRPQQFQFYQPQGIPSSPSAVVVEMGSKPAL 576
Query: 652 ASAP-LACAAAAPLTSPSITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSATKPDK 710
P L C + ++SL E + P LP P SA + +
Sbjct: 577 TGEPALTCISRGSEARIHSAASSLIMEDKEIPIKSEP-LPKPPASAPPSILVKPENSRNG 635
Query: 711 DSKKEKKGLLKLLSGASTKRKPRVSPPASPTLEVELGSAELPLQGAVGPELPPGGGHGRA 770
K+ K + S TK P L A P ++GPE+ H
Sbjct: 636 IEKQVKTVRFQNYSPPPTKHYTSHPTSGKPEQPATL-KASQPEAASLGPEMTVLFAHRSG 694
Query: 771 GSCPVDGD-------GPVTTAVAGAALAQDAFHRK 798
D G TT V+ A+ Q F K
Sbjct: 695 CHSGQQTDLRRKSALGKATTLVSTASGTQTVFPSK 729
Score = 40.4 bits (93), Expect = 0.007
Identities = 18/56 (32%), Positives = 34/56 (60%), Gaps = 2/56 (3%)
Query: 833 RHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
R + + +Y Q+ +L +GDI+ + ++ ++ W++G + NG +G FP S VE I
Sbjct: 129 RAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEI--NGISGNFPASSVEVI 182
Score = 40.0 bits (92), Expect = 0.010
Identities = 18/47 (38%), Positives = 28/47 (59%)
Query: 839 SYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFV 885
SY EL+L++G+ V V K +DGW +G G+ G+FP ++V
Sbjct: 390 SYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 140 bits (353), Expect = 5e-33
Identities = 124/411 (30%), Positives = 179/411 (43%), Gaps = 114/411 (27%)
Query: 108 SSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQV 167
S++D +S GG SP R + A+ ++++ + P +L KGDI+ + ++V
Sbjct: 361 STRDPSASNGGG-------SPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEV 413
Query: 168 DENWYHGEVNGIHGFFPTNFVQIIK----PLPQPPP--------QCKALYDFEVKDKEAD 215
D+NW GE +G G FP N+V+++ P P PP + A Y F+ D E +
Sbjct: 414 DKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFK-GDLEVE 472
Query: 216 KDCLPFAKDDVLTVIRRVDENWAEGML--ADKIGIFPISYVEFNSAAKQLIEWDKPPVPG 273
L F K + + +IR+V+ENW EG + + GIFP SYV+ + + + D P +P
Sbjct: 473 ---LSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLP- 528
Query: 274 VDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISPPVLIS 333
T+P+ LT A +S+ RH SP L S
Sbjct: 529 --------------TSPR----------------LTAAARSA-----RHPS--SPSALRS 551
Query: 334 SSNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPSDVPYQAALG 393
++P + S P+Q T + TP P+ + GPS P D LG
Sbjct: 552 PADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPS--HPLD------LG 603
Query: 394 TLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVYVAI 453
T +P +T QI H P Y A+
Sbjct: 604 TSSP------------------------------------NTSQI-HWTP------YRAM 620
Query: 454 YPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV 504
Y Y P+ EDELELR+G+ V ++C DGWF G S T K G FPGNYVAPV
Sbjct: 621 YQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
Score = 57.8 bits (138), Expect = 4e-08
Identities = 35/91 (38%), Positives = 47/91 (51%), Gaps = 16/91 (17%)
Query: 811 PPRQACSSLGPVLNESR------------PVVCERH----RVVVSYPPQSEAELELKEGD 854
P Q + GP L+ SR P + H R + Y PQ+E ELEL+EGD
Sbjct: 578 PQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGD 637
Query: 855 IVFVHKKREDGWFKGTLQRNGKTGLFPGSFV 885
V V ++ +DGWF G +R K G FPG++V
Sbjct: 638 RVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
Score = 48.9 bits (115), Expect = 2e-05
Identities = 46/178 (25%), Positives = 72/178 (40%), Gaps = 29/178 (16%)
Query: 709 DKDSKKEKKGLLKLLSGASTKRKPRVSPPASPTLEVELGSAELPLQGAVGPELPPGGGHG 768
DKD + + L S + +R P PPA P P G+ P H
Sbjct: 287 DKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSP----HK 342
Query: 769 RAGSCPVDGDGPVTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRP 828
A DG P L + F +S+ D P + P E +
Sbjct: 343 MA-----DGGSPF--------LGRRDFVYPSSTRD--------PSASNGGGSPARREEKK 381
Query: 829 VVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
+ R+ + QS EL L++GDIV++HK+ + W +G + +G+ G+FP ++VE
Sbjct: 382 R--KAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEG--EHHGRLGIFPANYVE 435
Score = 47.8 bits (112), Expect = 5e-05
Identities = 81/366 (22%), Positives = 124/366 (33%), Gaps = 57/366 (15%)
Query: 335 SNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVT---------TGPSFTFPSD 385
S P EL+ LS + T L P SSP GP+ + S
Sbjct: 268 SQPIEVLLERELAELSAELDKDLRAIETRL--PSPKSSPAPRRAPEQRPPAGPASAWSSS 325
Query: 386 VPYQAALGTLNPPLPPP------PLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIA 439
P+ LG+ P P L +A+ G P + A
Sbjct: 326 YPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAA 385
Query: 440 HLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGN 499
L+ + + + EL L+KG++ + + W +G H ++G+FP N
Sbjct: 386 RLK-----------FDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGE--HHGRLGIFPAN 432
Query: 500 YV------------APVTRAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGP----AQKL 543
YV P T V +A A T +G V S G +K+
Sbjct: 433 YVEVLPADEIPKPIKPPTYQVLEYGEA-----VAQYTFKGDLEVELSFRKGEHICLIRKV 487
Query: 544 QGNGVAGS-PSVVPAAVVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQERPT 602
N G + A+++Q S + ++ L G R +A + P+
Sbjct: 488 NENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPS 547
Query: 603 AAVTPIQVQNAAG-LSPASVGLSHHSLASPQPAPLMPGSATHTAAISISRA-SAPLACAA 660
A +P + G SP G S + +P P T A+S SR S PL
Sbjct: 548 ALRSPADPIDLGGQTSPRRTGF---SFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGT 604
Query: 661 AAPLTS 666
++P TS
Sbjct: 605 SSPNTS 610
Score = 38.1 bits (87), Expect = 0.037
Identities = 13/42 (30%), Positives = 27/42 (64%)
Query: 845 EAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
E EL ++G+ + + +K + W++G + G+ G+FP S+V+
Sbjct: 470 EVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQ 511
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 140 bits (353), Expect = 5e-33
Identities = 124/411 (30%), Positives = 179/411 (43%), Gaps = 114/411 (27%)
Query: 108 SSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQV 167
S++D +S GG SP R + A+ ++++ + P +L KGDI+ + ++V
Sbjct: 19 STRDPSASNGGG-------SPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEV 71
Query: 168 DENWYHGEVNGIHGFFPTNFVQIIK----PLPQPPP--------QCKALYDFEVKDKEAD 215
D+NW GE +G G FP N+V+++ P P PP + A Y F+ D E +
Sbjct: 72 DKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFK-GDLEVE 130
Query: 216 KDCLPFAKDDVLTVIRRVDENWAEGML--ADKIGIFPISYVEFNSAAKQLIEWDKPPVPG 273
L F K + + +IR+V+ENW EG + + GIFP SYV+ + + + D P +P
Sbjct: 131 ---LSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLP- 186
Query: 274 VDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISPPVLIS 333
T+P+ LT A +S+ RH SP L S
Sbjct: 187 --------------TSPR----------------LTAAARSA-----RHPS--SPSALRS 209
Query: 334 SSNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPSDVPYQAALG 393
++P + S P+Q T + TP P+ + GPS P D LG
Sbjct: 210 PADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPS--HPLD------LG 261
Query: 394 TLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVYVAI 453
T +P +T QI H P Y A+
Sbjct: 262 TSSP------------------------------------NTSQI-HWTP------YRAM 278
Query: 454 YPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV 504
Y Y P+ EDELELR+G+ V ++C DGWF G S T K G FPGNYVAPV
Sbjct: 279 YQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
Score = 57.8 bits (138), Expect = 4e-08
Identities = 35/91 (38%), Positives = 47/91 (51%), Gaps = 16/91 (17%)
Query: 811 PPRQACSSLGPVLNESR------------PVVCERH----RVVVSYPPQSEAELELKEGD 854
P Q + GP L+ SR P + H R + Y PQ+E ELEL+EGD
Sbjct: 236 PQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGD 295
Query: 855 IVFVHKKREDGWFKGTLQRNGKTGLFPGSFV 885
V V ++ +DGWF G +R K G FPG++V
Sbjct: 296 RVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
Score = 47.8 bits (112), Expect = 5e-05
Identities = 20/52 (38%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
R+ + QS EL L++GDIV++HK+ + W +G + +G+ G+FP ++VE
Sbjct: 44 RLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEG--EHHGRLGIFPANYVE 93
Score = 46.2 bits (108), Expect = 1e-04
Identities = 55/232 (23%), Positives = 88/232 (37%), Gaps = 29/232 (12%)
Query: 454 YPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV------------ 501
+ + + EL L+KG++ + + W +G H ++G+FP NYV
Sbjct: 47 FDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGE--HHGRLGIFPANYVEVLPADEIPKPI 104
Query: 502 APVTRAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGP----AQKLQGNGVAGS-PSVVP 556
P T V +A A T +G V S G +K+ N G
Sbjct: 105 KPPTYQVLEYGEA-----VAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGR 159
Query: 557 AAVVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQERPTAAVTPIQVQNAAG- 615
+ A+++Q S + ++ L G R +A + P+A +P + G
Sbjct: 160 QGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQ 219
Query: 616 LSPASVGLSHHSLASPQPAPLMPGSATHTAAISISRA-SAPLACAAAAPLTS 666
SP G S + +P P T A+S SR S PL ++P TS
Sbjct: 220 TSPRRTGF---SFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTS 268
Score = 41.6 bits (96), Expect = 0.003
Identities = 29/103 (28%), Positives = 46/103 (44%), Gaps = 8/103 (7%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV----APVTR 506
VA Y + E EL RKGE + + + W++G T + G+FP +YV P R
Sbjct: 118 VAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLR 177
Query: 507 AVTNASQAKVP--MSTAGQTSRGVTMVSPSTAGGPAQKLQGNG 547
+ Q ++ A +++R + SPS PA + G
Sbjct: 178 LCDDGPQLPTSPRLTAAARSARHPS--SPSALRSPADPIDLGG 218
Score = 38.1 bits (87), Expect = 0.037
Identities = 13/42 (30%), Positives = 27/42 (64%)
Query: 845 EAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
E EL ++G+ + + +K + W++G + G+ G+FP S+V+
Sbjct: 128 EVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQ 169
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 96.7 bits (239), Expect = 9e-20
Identities = 91/341 (26%), Positives = 139/341 (40%), Gaps = 50/341 (14%)
Query: 202 KALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAK 261
+A +DF+ + + LP K D++ + +++D+NW EG ++GIFP +Y+E A+
Sbjct: 821 RAKFDFKAQTLKE----LPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 876
Query: 262 QLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANK-------- 313
+ PV ++ GE A + + + +K T L ++
Sbjct: 877 KAQPKKLTPVQVLEYGE----AIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIP 932
Query: 314 --SSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQVHISTTGLIVTPP-- 369
S Q +++ L+ + S S +A Q +G
Sbjct: 933 GTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAER 992
Query: 370 ------PSSPVTTGPSFTFPSDV----PYQAALGTLNPPLPPPPLLAATVLASTPPGATA 419
P P + S PSDV + L LN P P L S PG+ A
Sbjct: 993 GAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRP---GKPLGSAFPGSEA 1049
Query: 420 A--------------AAAAGMGPRPMAGSTDQIAHLRPQTRPSV--YVAIYPYTPRKEDE 463
AA G +P A ++ R QT + Y A+Y Y P+ +DE
Sbjct: 1050 EQTERHRGGEQAGRKAARRGGSQQPQAQQR-RVTPDRSQTSQDLFSYQALYSYIPQNDDE 1108
Query: 464 LELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV 504
LELR G++ V E+C DGWF GTS T + G FPGNYV P+
Sbjct: 1109 LELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
Score = 81.3 bits (199), Expect = 4e-15
Identities = 49/167 (29%), Positives = 91/167 (54%), Gaps = 23/167 (13%)
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPP 198
A+A ++++ + +L KGDI+ + +Q+D+NWY GE +G G FP +++++ P +
Sbjct: 820 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 879
Query: 199 P------------QCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGML--AD 244
P + A ++F D + + + F K + +T++R+VDENW EG +
Sbjct: 880 PKKLTPVQVLEYGEAIAKFNFN-GDTQVE---MSFRKGERITLLRQVDENWYEGRIPGTS 935
Query: 245 KIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPK 291
+ GIFPI+YV+ + L+ K PV +D SS + ++ +P+
Sbjct: 936 RQGIFPITYVDV--IKRPLV---KNPVDYMDLPFSSSPSRSATASPQ 977
Score = 59.3 bits (142), Expect = 2e-08
Identities = 26/53 (49%), Positives = 40/53 (75%)
Query: 834 HRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
++ + SY PQ++ ELEL++GDIV V +K +DGWF GT +R + G FPG++V+
Sbjct: 1095 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1147
Score = 45.4 bits (106), Expect = 2e-04
Identities = 58/255 (22%), Positives = 99/255 (38%), Gaps = 51/255 (20%)
Query: 668 SITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSATKPDKDSKKEKKGLLKLLSGAS 727
S+ LEA+ L + T + S+ SSA P + E G + + +
Sbjct: 631 SLCQTELEAD--------LEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHA 682
Query: 728 TKRKPRVSPPASPTLEVE-------LGSAELPLQGAVGPELPPGGGHGRAGSCP---VDG 777
KR+ +P +LE E L ++PLQG G + P + P +
Sbjct: 683 VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA 742
Query: 778 DGPVTTAV---------AGAALAQDAFHRKASSLDSAVP----IAPPPRQACSS--LGPV 822
D +T Q R+ D A + P Q ++ G +
Sbjct: 743 DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDL 802
Query: 823 LN-----------ESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTL 871
LN E RP R + Q+ EL L++GDIV+++K+ + W++G
Sbjct: 803 LNIDDTAKRKSGSEMRPA-----RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG-- 855
Query: 872 QRNGKTGLFPGSFVE 886
+ +G+ G+FP +++E
Sbjct: 856 EHHGRVGIFPRTYIE 870
Score = 38.9 bits (89), Expect = 0.021
Identities = 19/79 (24%), Positives = 36/79 (45%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTN 510
+A + + + E+ RKGE + + + W++G TS+ G+FP YV + R +
Sbjct: 895 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVK 954
Query: 511 ASQAKVPMSTAGQTSRGVT 529
+ + + SR T
Sbjct: 955 NPVDYMDLPFSSSPSRSAT 973
Score = 35.4 bits (80), Expect = 0.24
Identities = 32/118 (27%), Positives = 51/118 (43%), Gaps = 8/118 (6%)
Query: 82 KPGPGGGSGTNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWS-PPVRG--IPQLPC 138
+PG GS + A +++ + + G QQP+ Q P R L
Sbjct: 1035 RPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFS 1094
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGI--HGFFPTNFVQIIKPL 194
+ALY+Y + +L+ GDI+ + + D+ W+ G G FP N+V KPL
Sbjct: 1095 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV---KPL 1149
Score = 31.2 bits (69), Expect = 4.5
Identities = 9/45 (20%), Positives = 29/45 (64%)
Query: 844 SEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
++ E+ ++G+ + + ++ ++ W++G + + G+FP ++V+ I
Sbjct: 904 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 948
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 95.5 bits (236), Expect = 2e-19
Identities = 66/206 (32%), Positives = 106/206 (51%), Gaps = 26/206 (12%)
Query: 88 GSGTNCTNALRSQSSTVANCSSKDLQSSQ---------GGQQPRVQSWSPPVRGIPQLPC 138
GS T T + S SS + +KD +S + G PR + +P +P
Sbjct: 205 GSSTTLTKSFTS-SSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLP---- 259
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKP----- 193
AKA+Y+++ + +L F KGD + + R++D+NWY GE +G G FP ++V+ + P
Sbjct: 260 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 319
Query: 194 --LPQPPPQCKALYDFEVK-DKEADKDC-LPFAKDDVLTVIRRVDENWAEGML--ADKIG 247
P PP Q + + K + AD + L K D + +++RVD+NW EG + ++ G
Sbjct: 320 PARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 379
Query: 248 IFPISYVE-FNSAAKQLIEWDKPPVP 272
IFP+SYVE K ++ PP+P
Sbjct: 380 IFPVSYVEVVKKNTKGAEDYPDPPIP 405
Score = 72.0 bits (175), Expect = 2e-12
Identities = 31/52 (59%), Positives = 37/52 (71%)
Query: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
+ A+Y YTPR EDELELR+ ++ V E+C DGWF GTS T G FPGNYV
Sbjct: 438 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 489
Score = 55.8 bits (133), Expect = 2e-07
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 832 ERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
E + + +Y P++E ELEL+E D++ V +K +DGWF GT +R G FPG++V+ +
Sbjct: 436 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
Score = 44.7 bits (104), Expect = 4e-04
Identities = 48/216 (22%), Positives = 85/216 (39%), Gaps = 46/216 (21%)
Query: 686 LPGLPTS-PDSASSACGNSSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSP-----PAS 739
LPG T+ S +S+ +S + D++S + L + G S R+ R +P PA
Sbjct: 203 LPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM-GRSAPRERRGTPEKEKLPAK 261
Query: 740 PTLEVELG-SAELPLQGA--------VGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAAL 790
+ + S EL + + G HGR G P+
Sbjct: 262 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPI--------------- 306
Query: 791 AQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELEL 850
++ K + + A P PPP +G + + ++ + EL L
Sbjct: 307 ---SYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK------------YNFNADTNVELSL 351
Query: 851 KEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
++GD V + K+ + W++G + + G+FP S+VE
Sbjct: 352 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 387
Score = 44.7 bits (104), Expect = 4e-04
Identities = 18/54 (33%), Positives = 34/54 (62%), Gaps = 2/54 (3%)
Query: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
+ V + Q+ EL K+GD V++ +K + W++G + +G+ G+FP S+VE +
Sbjct: 261 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 312
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/100 (25%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV---TRA 507
+A Y + EL LRKG+ ++ +R W++G T++ G+FP +YV V T+
Sbjct: 336 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 395
Query: 508 VTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNG 547
+ +P S + ++ P + +QG G
Sbjct: 396 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 435
Score = 39.3 bits (90), Expect = 0.016
Identities = 15/54 (27%), Positives = 29/54 (53%), Gaps = 2/54 (3%)
Query: 452 AIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505
A+Y + + EL +KG+ + + W++G H ++G+FP +YV +T
Sbjct: 262 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLT 313
Score = 34.7 bits (78), Expect = 0.40
Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHG--EVNGIHGFFPTNFVQ 189
+ALYNY + +L+ + D+I + + D+ W+ G G FP N+V+
Sbjct: 439 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 95.5 bits (236), Expect = 2e-19
Identities = 66/206 (32%), Positives = 106/206 (51%), Gaps = 26/206 (12%)
Query: 88 GSGTNCTNALRSQSSTVANCSSKDLQSSQ---------GGQQPRVQSWSPPVRGIPQLPC 138
GS T T + S SS + +KD +S + G PR + +P +P
Sbjct: 537 GSSTTLTKSFTS-SSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLP---- 591
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKP----- 193
AKA+Y+++ + +L F KGD + + R++D+NWY GE +G G FP ++V+ + P
Sbjct: 592 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 651
Query: 194 --LPQPPPQCKALYDFEVK-DKEADKDC-LPFAKDDVLTVIRRVDENWAEGML--ADKIG 247
P PP Q + + K + AD + L K D + +++RVD+NW EG + ++ G
Sbjct: 652 PARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 711
Query: 248 IFPISYVE-FNSAAKQLIEWDKPPVP 272
IFP+SYVE K ++ PP+P
Sbjct: 712 IFPVSYVEVVKKNTKGAEDYPDPPIP 737
Score = 72.0 bits (175), Expect = 2e-12
Identities = 31/52 (59%), Positives = 37/52 (71%)
Query: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
+ A+Y YTPR EDELELR+ ++ V E+C DGWF GTS T G FPGNYV
Sbjct: 770 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 821
Score = 55.8 bits (133), Expect = 2e-07
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 832 ERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
E + + +Y P++E ELEL+E D++ V +K +DGWF GT +R G FPG++V+ +
Sbjct: 768 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
Score = 49.7 bits (117), Expect = 1e-05
Identities = 70/276 (25%), Positives = 103/276 (37%), Gaps = 61/276 (22%)
Query: 630 SPQPAPLMPGSATHTAAISISRASAPLACAAAAPLT-SPSITSASLEAEPSGRIVTVLPG 688
+P P P PG PL+ + +T SPS S PS R + P
Sbjct: 413 TPTPVPREPGRK-------------PLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPT 459
Query: 689 LPTSP------DSASSACGNSSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSPPASPTL 742
P D +S +S + D E+ + S AS RK R S PA
Sbjct: 460 RPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERP--MSSASMASDFRKRRKSEPA---- 513
Query: 743 EVELGSAELPLQGAVGPELPPGGGH---GRAGSCPVDGDGPVTTAVAGAALAQDAFHRKA 799
VGP P G G R VD G TT + + +A
Sbjct: 514 --------------VGP--PRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRA 557
Query: 800 SSLDSAVPIAPPPRQACSSL---GPVLNESRPVVCERHRV----VVSYPPQSEAELELKE 852
+S PR S+L G R E+ ++ V + Q+ EL K+
Sbjct: 558 KDRES-------PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 610
Query: 853 GDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
GD V++ +K + W++G + +G+ G+FP S+VE +
Sbjct: 611 GDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 644
Score = 44.7 bits (104), Expect = 4e-04
Identities = 48/216 (22%), Positives = 85/216 (39%), Gaps = 46/216 (21%)
Query: 686 LPGLPTS-PDSASSACGNSSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSP-----PAS 739
LPG T+ S +S+ +S + D++S + L + G S R+ R +P PA
Sbjct: 535 LPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM-GRSAPRERRGTPEKEKLPAK 593
Query: 740 PTLEVELG-SAELPLQGA--------VGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAAL 790
+ + S EL + + G HGR G P+
Sbjct: 594 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPI--------------- 638
Query: 791 AQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELEL 850
++ K + + A P PPP +G + + ++ + EL L
Sbjct: 639 ---SYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK------------YNFNADTNVELSL 683
Query: 851 KEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
++GD V + K+ + W++G + + G+FP S+VE
Sbjct: 684 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 719
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/100 (25%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV---TRA 507
+A Y + EL LRKG+ ++ +R W++G T++ G+FP +YV V T+
Sbjct: 668 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 727
Query: 508 VTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNG 547
+ +P S + ++ P + +QG G
Sbjct: 728 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 767
Score = 40.0 bits (92), Expect = 0.010
Identities = 62/300 (20%), Positives = 106/300 (35%), Gaps = 71/300 (23%)
Query: 269 PPVPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISP 328
PPVP + + SS P D K +T+K S + ++S +H E P
Sbjct: 354 PPVPPLRPRDRSSTEKHDWDPP---DRKVDTRKFRSEPRSIFEYEPGKSSILQH--ERPP 408
Query: 329 PVLISSS--------NPTAAARISELSGLSCSAPSQVHISTTG-----LIVTPPPSSP-- 373
P+ + + P +++R+ E++G S S P + T L T PP P
Sbjct: 409 PLPTTPTPVPREPGRKPLSSSRLGEVTG-SPSPPPRSGAPTPSSRAPALSPTRPPKKPLD 467
Query: 374 -VTTGPSFTFPSDVPYQAALGTL--------------------NPPLPPPPLLAATVLAS 412
V S F YQ+++ P + PP L +
Sbjct: 468 YVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASR 527
Query: 413 TPPG--------------------ATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSV--- 449
T PG ++ + A PR + + + P+ R
Sbjct: 528 TSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK 587
Query: 450 ----YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505
A+Y + + EL +KG+ + + W++G H ++G+FP +YV +T
Sbjct: 588 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLT 645
Score = 34.7 bits (78), Expect = 0.40
Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHG--EVNGIHGFFPTNFVQ 189
+ALYNY + +L+ + D+I + + D+ W+ G G FP N+V+
Sbjct: 771 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 822
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 95.5 bits (236), Expect = 2e-19
Identities = 66/206 (32%), Positives = 106/206 (51%), Gaps = 26/206 (12%)
Query: 88 GSGTNCTNALRSQSSTVANCSSKDLQSSQ---------GGQQPRVQSWSPPVRGIPQLPC 138
GS T T + S SS + +KD +S + G PR + +P +P
Sbjct: 374 GSSTTLTKSFTS-SSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLP---- 428
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKP----- 193
AKA+Y+++ + +L F KGD + + R++D+NWY GE +G G FP ++V+ + P
Sbjct: 429 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 488
Query: 194 --LPQPPPQCKALYDFEVK-DKEADKDC-LPFAKDDVLTVIRRVDENWAEGML--ADKIG 247
P PP Q + + K + AD + L K D + +++RVD+NW EG + ++ G
Sbjct: 489 PARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 548
Query: 248 IFPISYVE-FNSAAKQLIEWDKPPVP 272
IFP+SYVE K ++ PP+P
Sbjct: 549 IFPVSYVEVVKKNTKGAEDYPDPPIP 574
Score = 72.0 bits (175), Expect = 2e-12
Identities = 31/52 (59%), Positives = 37/52 (71%)
Query: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
+ A+Y YTPR EDELELR+ ++ V E+C DGWF GTS T G FPGNYV
Sbjct: 607 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 658
Score = 55.8 bits (133), Expect = 2e-07
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 832 ERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
E + + +Y P++E ELEL+E D++ V +K +DGWF GT +R G FPG++V+ +
Sbjct: 605 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
Score = 44.7 bits (104), Expect = 4e-04
Identities = 48/216 (22%), Positives = 85/216 (39%), Gaps = 46/216 (21%)
Query: 686 LPGLPTS-PDSASSACGNSSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSP-----PAS 739
LPG T+ S +S+ +S + D++S + L + G S R+ R +P PA
Sbjct: 372 LPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM-GRSAPRERRGTPEKEKLPAK 430
Query: 740 PTLEVELG-SAELPLQGA--------VGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAAL 790
+ + S EL + + G HGR G P+
Sbjct: 431 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPI--------------- 475
Query: 791 AQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELEL 850
++ K + + A P PPP +G + + ++ + EL L
Sbjct: 476 ---SYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK------------YNFNADTNVELSL 520
Query: 851 KEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
++GD V + K+ + W++G + + G+FP S+VE
Sbjct: 521 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 556
Score = 44.7 bits (104), Expect = 4e-04
Identities = 18/54 (33%), Positives = 34/54 (62%), Gaps = 2/54 (3%)
Query: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
+ V + Q+ EL K+GD V++ +K + W++G + +G+ G+FP S+VE +
Sbjct: 430 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 481
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/100 (25%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV---TRA 507
+A Y + EL LRKG+ ++ +R W++G T++ G+FP +YV V T+
Sbjct: 505 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 564
Query: 508 VTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNG 547
+ +P S + ++ P + +QG G
Sbjct: 565 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 604
Score = 39.3 bits (90), Expect = 0.016
Identities = 15/54 (27%), Positives = 29/54 (53%), Gaps = 2/54 (3%)
Query: 452 AIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505
A+Y + + EL +KG+ + + W++G H ++G+FP +YV +T
Sbjct: 431 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLT 482
Score = 34.7 bits (78), Expect = 0.40
Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHG--EVNGIHGFFPTNFVQ 189
+ALYNY + +L+ + D+I + + D+ W+ G G FP N+V+
Sbjct: 608 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 659
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 95.5 bits (236), Expect = 2e-19
Identities = 66/206 (32%), Positives = 106/206 (51%), Gaps = 26/206 (12%)
Query: 88 GSGTNCTNALRSQSSTVANCSSKDLQSSQ---------GGQQPRVQSWSPPVRGIPQLPC 138
GS T T + S SS + +KD +S + G PR + +P +P
Sbjct: 444 GSSTTLTKSFTS-SSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLP---- 498
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKP----- 193
AKA+Y+++ + +L F KGD + + R++D+NWY GE +G G FP ++V+ + P
Sbjct: 499 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 558
Query: 194 --LPQPPPQCKALYDFEVK-DKEADKDC-LPFAKDDVLTVIRRVDENWAEGML--ADKIG 247
P PP Q + + K + AD + L K D + +++RVD+NW EG + ++ G
Sbjct: 559 PARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 618
Query: 248 IFPISYVE-FNSAAKQLIEWDKPPVP 272
IFP+SYVE K ++ PP+P
Sbjct: 619 IFPVSYVEVVKKNTKGAEDYPDPPIP 644
Score = 72.0 bits (175), Expect = 2e-12
Identities = 31/52 (59%), Positives = 37/52 (71%)
Query: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
+ A+Y YTPR EDELELR+ ++ V E+C DGWF GTS T G FPGNYV
Sbjct: 677 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 728
Score = 55.8 bits (133), Expect = 2e-07
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 832 ERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
E + + +Y P++E ELEL+E D++ V +K +DGWF GT +R G FPG++V+ +
Sbjct: 675 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
Score = 49.7 bits (117), Expect = 1e-05
Identities = 70/276 (25%), Positives = 103/276 (37%), Gaps = 61/276 (22%)
Query: 630 SPQPAPLMPGSATHTAAISISRASAPLACAAAAPLT-SPSITSASLEAEPSGRIVTVLPG 688
+P P P PG PL+ + +T SPS S PS R + P
Sbjct: 320 TPTPVPREPGRK-------------PLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPT 366
Query: 689 LPTSP------DSASSACGNSSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSPPASPTL 742
P D +S +S + D E+ + S AS RK R S PA
Sbjct: 367 RPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERP--MSSASMASDFRKRRKSEPA---- 420
Query: 743 EVELGSAELPLQGAVGPELPPGGGH---GRAGSCPVDGDGPVTTAVAGAALAQDAFHRKA 799
VGP P G G R VD G TT + + +A
Sbjct: 421 --------------VGP--PRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRA 464
Query: 800 SSLDSAVPIAPPPRQACSSL---GPVLNESRPVVCERHRV----VVSYPPQSEAELELKE 852
+S PR S+L G R E+ ++ V + Q+ EL K+
Sbjct: 465 KDRES-------PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 517
Query: 853 GDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
GD V++ +K + W++G + +G+ G+FP S+VE +
Sbjct: 518 GDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 551
Score = 44.7 bits (104), Expect = 4e-04
Identities = 48/216 (22%), Positives = 85/216 (39%), Gaps = 46/216 (21%)
Query: 686 LPGLPTS-PDSASSACGNSSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSP-----PAS 739
LPG T+ S +S+ +S + D++S + L + G S R+ R +P PA
Sbjct: 442 LPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM-GRSAPRERRGTPEKEKLPAK 500
Query: 740 PTLEVELG-SAELPLQGA--------VGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAAL 790
+ + S EL + + G HGR G P+
Sbjct: 501 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPI--------------- 545
Query: 791 AQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELEL 850
++ K + + A P PPP +G + + ++ + EL L
Sbjct: 546 ---SYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK------------YNFNADTNVELSL 590
Query: 851 KEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
++GD V + K+ + W++G + + G+FP S+VE
Sbjct: 591 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 626
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/100 (25%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV---TRA 507
+A Y + EL LRKG+ ++ +R W++G T++ G+FP +YV V T+
Sbjct: 575 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 634
Query: 508 VTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNG 547
+ +P S + ++ P + +QG G
Sbjct: 635 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 674
Score = 40.0 bits (92), Expect = 0.010
Identities = 62/300 (20%), Positives = 106/300 (35%), Gaps = 71/300 (23%)
Query: 269 PPVPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISP 328
PPVP + + SS P D K +T+K S + ++S +H E P
Sbjct: 261 PPVPPLRPRDRSSTEKHDWDPP---DRKVDTRKFRSEPRSIFEYEPGKSSILQH--ERPP 315
Query: 329 PVLISSS--------NPTAAARISELSGLSCSAPSQVHISTTG-----LIVTPPPSSP-- 373
P+ + + P +++R+ E++G S S P + T L T PP P
Sbjct: 316 PLPTTPTPVPREPGRKPLSSSRLGEVTG-SPSPPPRSGAPTPSSRAPALSPTRPPKKPLD 374
Query: 374 -VTTGPSFTFPSDVPYQAALGTL--------------------NPPLPPPPLLAATVLAS 412
V S F YQ+++ P + PP L +
Sbjct: 375 YVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASR 434
Query: 413 TPPG--------------------ATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSV--- 449
T PG ++ + A PR + + + P+ R
Sbjct: 435 TSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK 494
Query: 450 ----YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505
A+Y + + EL +KG+ + + W++G H ++G+FP +YV +T
Sbjct: 495 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLT 552
Score = 34.7 bits (78), Expect = 0.40
Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHG--EVNGIHGFFPTNFVQ 189
+ALYNY + +L+ + D+I + + D+ W+ G G FP N+V+
Sbjct: 678 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 729
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 95.5 bits (236), Expect = 2e-19
Identities = 66/206 (32%), Positives = 106/206 (51%), Gaps = 26/206 (12%)
Query: 88 GSGTNCTNALRSQSSTVANCSSKDLQSSQ---------GGQQPRVQSWSPPVRGIPQLPC 138
GS T T + S SS + +KD +S + G PR + +P +P
Sbjct: 357 GSSTTLTKSFTS-SSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLP---- 411
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKP----- 193
AKA+Y+++ + +L F KGD + + R++D+NWY GE +G G FP ++V+ + P
Sbjct: 412 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 471
Query: 194 --LPQPPPQCKALYDFEVK-DKEADKDC-LPFAKDDVLTVIRRVDENWAEGML--ADKIG 247
P PP Q + + K + AD + L K D + +++RVD+NW EG + ++ G
Sbjct: 472 PARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 531
Query: 248 IFPISYVE-FNSAAKQLIEWDKPPVP 272
IFP+SYVE K ++ PP+P
Sbjct: 532 IFPVSYVEVVKKNTKGAEDYPDPPIP 557
Score = 72.0 bits (175), Expect = 2e-12
Identities = 31/52 (59%), Positives = 37/52 (71%)
Query: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
+ A+Y YTPR EDELELR+ ++ V E+C DGWF GTS T G FPGNYV
Sbjct: 590 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 641
Score = 55.8 bits (133), Expect = 2e-07
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 832 ERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
E + + +Y P++E ELEL+E D++ V +K +DGWF GT +R G FPG++V+ +
Sbjct: 588 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
Score = 44.7 bits (104), Expect = 4e-04
Identities = 48/216 (22%), Positives = 85/216 (39%), Gaps = 46/216 (21%)
Query: 686 LPGLPTS-PDSASSACGNSSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSP-----PAS 739
LPG T+ S +S+ +S + D++S + L + G S R+ R +P PA
Sbjct: 355 LPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM-GRSAPRERRGTPEKEKLPAK 413
Query: 740 PTLEVELG-SAELPLQGA--------VGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAAL 790
+ + S EL + + G HGR G P+
Sbjct: 414 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPI--------------- 458
Query: 791 AQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELEL 850
++ K + + A P PPP +G + + ++ + EL L
Sbjct: 459 ---SYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK------------YNFNADTNVELSL 503
Query: 851 KEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
++GD V + K+ + W++G + + G+FP S+VE
Sbjct: 504 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 539
Score = 44.7 bits (104), Expect = 4e-04
Identities = 18/54 (33%), Positives = 34/54 (62%), Gaps = 2/54 (3%)
Query: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
+ V + Q+ EL K+GD V++ +K + W++G + +G+ G+FP S+VE +
Sbjct: 413 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 464
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/100 (25%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV---TRA 507
+A Y + EL LRKG+ ++ +R W++G T++ G+FP +YV V T+
Sbjct: 488 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 547
Query: 508 VTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNG 547
+ +P S + ++ P + +QG G
Sbjct: 548 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 587
Score = 39.3 bits (90), Expect = 0.016
Identities = 15/54 (27%), Positives = 29/54 (53%), Gaps = 2/54 (3%)
Query: 452 AIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505
A+Y + + EL +KG+ + + W++G H ++G+FP +YV +T
Sbjct: 414 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLT 465
Score = 34.7 bits (78), Expect = 0.40
Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHG--EVNGIHGFFPTNFVQ 189
+ALYNY + +L+ + D+I + + D+ W+ G G FP N+V+
Sbjct: 591 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 95.5 bits (236), Expect = 2e-19
Identities = 66/206 (32%), Positives = 106/206 (51%), Gaps = 26/206 (12%)
Query: 88 GSGTNCTNALRSQSSTVANCSSKDLQSSQ---------GGQQPRVQSWSPPVRGIPQLPC 138
GS T T + S SS + +KD +S + G PR + +P +P
Sbjct: 379 GSSTTLTKSFTS-SSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLP---- 433
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKP----- 193
AKA+Y+++ + +L F KGD + + R++D+NWY GE +G G FP ++V+ + P
Sbjct: 434 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 493
Query: 194 --LPQPPPQCKALYDFEVK-DKEADKDC-LPFAKDDVLTVIRRVDENWAEGML--ADKIG 247
P PP Q + + K + AD + L K D + +++RVD+NW EG + ++ G
Sbjct: 494 PARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 553
Query: 248 IFPISYVE-FNSAAKQLIEWDKPPVP 272
IFP+SYVE K ++ PP+P
Sbjct: 554 IFPVSYVEVVKKNTKGAEDYPDPPIP 579
Score = 72.0 bits (175), Expect = 2e-12
Identities = 31/52 (59%), Positives = 37/52 (71%)
Query: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
+ A+Y YTPR EDELELR+ ++ V E+C DGWF GTS T G FPGNYV
Sbjct: 612 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 663
Score = 55.8 bits (133), Expect = 2e-07
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 832 ERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
E + + +Y P++E ELEL+E D++ V +K +DGWF GT +R G FPG++V+ +
Sbjct: 610 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666
Score = 44.7 bits (104), Expect = 4e-04
Identities = 48/216 (22%), Positives = 85/216 (39%), Gaps = 46/216 (21%)
Query: 686 LPGLPTS-PDSASSACGNSSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSP-----PAS 739
LPG T+ S +S+ +S + D++S + L + G S R+ R +P PA
Sbjct: 377 LPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM-GRSAPRERRGTPEKEKLPAK 435
Query: 740 PTLEVELG-SAELPLQGA--------VGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAAL 790
+ + S EL + + G HGR G P+
Sbjct: 436 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPI--------------- 480
Query: 791 AQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELEL 850
++ K + + A P PPP +G + + ++ + EL L
Sbjct: 481 ---SYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK------------YNFNADTNVELSL 525
Query: 851 KEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
++GD V + K+ + W++G + + G+FP S+VE
Sbjct: 526 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 561
Score = 44.7 bits (104), Expect = 4e-04
Identities = 18/54 (33%), Positives = 34/54 (62%), Gaps = 2/54 (3%)
Query: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
+ V + Q+ EL K+GD V++ +K + W++G + +G+ G+FP S+VE +
Sbjct: 435 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 486
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/100 (25%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV---TRA 507
+A Y + EL LRKG+ ++ +R W++G T++ G+FP +YV V T+
Sbjct: 510 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 569
Query: 508 VTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNG 547
+ +P S + ++ P + +QG G
Sbjct: 570 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 609
Score = 39.3 bits (90), Expect = 0.016
Identities = 15/54 (27%), Positives = 29/54 (53%), Gaps = 2/54 (3%)
Query: 452 AIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505
A+Y + + EL +KG+ + + W++G H ++G+FP +YV +T
Sbjct: 436 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLT 487
Score = 34.7 bits (78), Expect = 0.40
Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHG--EVNGIHGFFPTNFVQ 189
+ALYNY + +L+ + D+I + + D+ W+ G G FP N+V+
Sbjct: 613 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 664
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 93.2 bits (230), Expect = 1e-18
Identities = 61/187 (32%), Positives = 98/187 (52%), Gaps = 25/187 (13%)
Query: 98 RSQSSTVANCSSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSK 157
RS SST+ + G PR + +P +P AKA+Y+++ + +L F K
Sbjct: 744 RSYSSTLTD---------MGRSAPRERRGTPEKEKLP----AKAVYDFKAQTSKELSFKK 790
Query: 158 GDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKP-------LPQPPPQCKALYDFEVK 210
GD + + R++D+NWY GE +G G FP ++V+ + P P PP Q + + K
Sbjct: 791 GDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK 850
Query: 211 -DKEADKDC-LPFAKDDVLTVIRRVDENWAEGML--ADKIGIFPISYVE-FNSAAKQLIE 265
+ AD + L K D + +++RVD+NW EG + ++ GIFP+SYVE K +
Sbjct: 851 YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAED 910
Query: 266 WDKPPVP 272
+ PP+P
Sbjct: 911 YPDPPIP 917
Score = 72.0 bits (175), Expect = 2e-12
Identities = 31/52 (59%), Positives = 37/52 (71%)
Query: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
+ A+Y YTPR EDELELR+ ++ V E+C DGWF GTS T G FPGNYV
Sbjct: 950 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 1001
Score = 55.8 bits (133), Expect = 2e-07
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 832 ERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
E + + +Y P++E ELEL+E D++ V +K +DGWF GT +R G FPG++V+ +
Sbjct: 948 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 44.7 bits (104), Expect = 4e-04
Identities = 18/54 (33%), Positives = 34/54 (62%), Gaps = 2/54 (3%)
Query: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
+ V + Q+ EL K+GD V++ +K + W++G + +G+ G+FP S+VE +
Sbjct: 773 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 824
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/100 (25%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV---TRA 507
+A Y + EL LRKG+ ++ +R W++G T++ G+FP +YV V T+
Sbjct: 848 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 907
Query: 508 VTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNG 547
+ +P S + ++ P + +QG G
Sbjct: 908 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 947
Score = 43.9 bits (102), Expect = 7e-04
Identities = 28/123 (22%), Positives = 50/123 (40%), Gaps = 30/123 (24%)
Query: 764 GGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVL 823
G HGR G P+ ++ K + + A P PPP +G +
Sbjct: 807 GEHHGRVGIFPI------------------SYVEKLTPPEKAQPARPPPPAQPGEIGEAI 848
Query: 824 NESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGS 883
+ ++ + EL L++GD V + K+ + W++G + + G+FP S
Sbjct: 849 AK------------YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 896
Query: 884 FVE 886
+VE
Sbjct: 897 YVE 899
Score = 39.3 bits (90), Expect = 0.016
Identities = 15/54 (27%), Positives = 29/54 (53%), Gaps = 2/54 (3%)
Query: 452 AIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505
A+Y + + EL +KG+ + + W++G H ++G+FP +YV +T
Sbjct: 774 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLT 825
Score = 34.7 bits (78), Expect = 0.40
Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHG--EVNGIHGFFPTNFVQ 189
+ALYNY + +L+ + D+I + + D+ W+ G G FP N+V+
Sbjct: 951 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 93.2 bits (230), Expect = 1e-18
Identities = 61/187 (32%), Positives = 98/187 (52%), Gaps = 25/187 (13%)
Query: 98 RSQSSTVANCSSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSK 157
RS SST+ + G PR + +P +P AKA+Y+++ + +L F K
Sbjct: 840 RSYSSTLTD---------MGRSAPRERRGTPEKEKLP----AKAVYDFKAQTSKELSFKK 886
Query: 158 GDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKP-------LPQPPPQCKALYDFEVK 210
GD + + R++D+NWY GE +G G FP ++V+ + P P PP Q + + K
Sbjct: 887 GDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK 946
Query: 211 -DKEADKDC-LPFAKDDVLTVIRRVDENWAEGML--ADKIGIFPISYVE-FNSAAKQLIE 265
+ AD + L K D + +++RVD+NW EG + ++ GIFP+SYVE K +
Sbjct: 947 YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAED 1006
Query: 266 WDKPPVP 272
+ PP+P
Sbjct: 1007 YPDPPIP 1013
Score = 72.0 bits (175), Expect = 2e-12
Identities = 31/52 (59%), Positives = 37/52 (71%)
Query: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
+ A+Y YTPR EDELELR+ ++ V E+C DGWF GTS T G FPGNYV
Sbjct: 1046 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 1097
Score = 55.8 bits (133), Expect = 2e-07
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 832 ERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
E + + +Y P++E ELEL+E D++ V +K +DGWF GT +R G FPG++V+ +
Sbjct: 1044 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
Score = 44.7 bits (104), Expect = 4e-04
Identities = 18/54 (33%), Positives = 34/54 (62%), Gaps = 2/54 (3%)
Query: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
+ V + Q+ EL K+GD V++ +K + W++G + +G+ G+FP S+VE +
Sbjct: 869 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 920
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/100 (25%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV---TRA 507
+A Y + EL LRKG+ ++ +R W++G T++ G+FP +YV V T+
Sbjct: 944 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 1003
Query: 508 VTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNG 547
+ +P S + ++ P + +QG G
Sbjct: 1004 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 1043
Score = 43.9 bits (102), Expect = 7e-04
Identities = 28/123 (22%), Positives = 50/123 (40%), Gaps = 30/123 (24%)
Query: 764 GGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVL 823
G HGR G P+ ++ K + + A P PPP +G +
Sbjct: 903 GEHHGRVGIFPI------------------SYVEKLTPPEKAQPARPPPPAQPGEIGEAI 944
Query: 824 NESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGS 883
+ ++ + EL L++GD V + K+ + W++G + + G+FP S
Sbjct: 945 AK------------YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 992
Query: 884 FVE 886
+VE
Sbjct: 993 YVE 995
Score = 39.3 bits (90), Expect = 0.016
Identities = 15/54 (27%), Positives = 29/54 (53%), Gaps = 2/54 (3%)
Query: 452 AIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505
A+Y + + EL +KG+ + + W++G H ++G+FP +YV +T
Sbjct: 870 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLT 921
Score = 34.7 bits (78), Expect = 0.40
Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHG--EVNGIHGFFPTNFVQ 189
+ALYNY + +L+ + D+I + + D+ W+ G G FP N+V+
Sbjct: 1047 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 86.3 bits (212), Expect = 1e-16
Identities = 108/465 (23%), Positives = 180/465 (38%), Gaps = 78/465 (16%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTN 510
+A + + + E+ RKGE + + + W++G TS+ G+FP YV + R +
Sbjct: 873 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVK 932
Query: 511 ASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNGVAGSPSVVP---AAVVSAAHIQT 567
+ + + SR T P + +PS +P A+ H T
Sbjct: 933 NPVDYMDLPFSSSPSRSAT-------ASPQFSSHSKLITPAPSSLPHSRRALSPEMHAVT 985
Query: 568 SPQAKVLLHMTGQMTVNQARNAVRTVAAHNQERPTAAVTPIQVQNAAGLSPASVGLSHHS 627
S + + + G R + A+TP L AS+ + H
Sbjct: 986 SEWISLTVGVPG--------------------RRSLALTP----PLPPLPEASIYNTDHL 1021
Query: 628 LASPQPAPLMPGSATHTAAISISRASAPLACAAAAPLTSPS---------ITSASLEAEP 678
SP+ +P + S H +S + P + A+PL PS + ASL
Sbjct: 1022 ALSPRASPSLSLSLPH-----LSWSDRPTPRSVASPLALPSPHKTYSLAPTSQASLHMNG 1076
Query: 679 SGRIVTVLPGLPT---------SPDSASSACGNSSATKPDKDSKKEKKGLL--KLLSGAS 727
G + T G+ S DS S ++ +++ + +E+ G K GA
Sbjct: 1077 DGGVHTPSSGIHQDSFLQLPLGSSDSVISQLSDAFSSQSKRQPWREESGQYERKAERGAG 1136
Query: 728 TKRK--PRVSPPA--SPTLEVELGSAELPLQGAVGPELPPGGGHGRAGSCPVDGDGPVTT 783
+ P++S + P+ V S E L PE R G P+ +
Sbjct: 1137 ERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPE------ESRPGK-------PLGS 1183
Query: 784 AVAGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCE--RHRVVVSYP 841
A G+ Q HR +Q + V + + ++ + SY
Sbjct: 1184 AFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYI 1243
Query: 842 PQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
PQ++ ELEL++GDIV V +K +DGWF GT +R + G FPG++V+
Sbjct: 1244 PQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
Score = 84.0 bits (206), Expect = 6e-16
Identities = 79/310 (25%), Positives = 135/310 (43%), Gaps = 46/310 (14%)
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPP 198
A+A ++++ + +L KGDI+ + +Q+D+NWY GE +G G FP +++++ P +
Sbjct: 798 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 857
Query: 199 P------------QCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGML--AD 244
P + A ++F D + + + F K + +T++R+VDENW EG +
Sbjct: 858 PKKLTPVQVLEYGEAIAKFNFN-GDTQVE---MSFRKGERITLLRQVDENWYEGRIPGTS 913
Query: 245 KIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHS 304
+ GIFPI+YV+ + L+ K PV +D SS + ++ +P+ S K
Sbjct: 914 RQGIFPITYVDV--IKRPLV---KNPVDYMDLPFSSSPSRSATASPQFSSHSK------- 961
Query: 305 FTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQVHISTTGL 364
+T A S S+ + +P A SE L+ P + ++ T
Sbjct: 962 --LITPAPSSLPHSRR-------------ALSPEMHAVTSEWISLTVGVPGRRSLALTPP 1006
Query: 365 IVTPPPSSPVTTGPSFTFPSDVP-YQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAA 423
+ P +S T P P +L L+ P P A+ LA P T + A
Sbjct: 1007 LPPLPEASIYNTDHLALSPRASPSLSLSLPHLSWSDRPTPRSVASPLALPSPHKTYSLAP 1066
Query: 424 AGMGPRPMAG 433
M G
Sbjct: 1067 TSQASLHMNG 1076
Score = 78.2 bits (191), Expect = 3e-14
Identities = 56/155 (36%), Positives = 71/155 (45%), Gaps = 24/155 (15%)
Query: 370 PSSPVTTGPSFTFPSDV----PYQAALGTLNPPLPPPPLLAATVLASTPPGATAA----- 420
P P + S PSDV + L LN P P L S PG+ A
Sbjct: 1140 PGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRP---GKPLGSAFPGSEAEQTERH 1196
Query: 421 ---------AAAAGMGPRPMAGSTDQIAHLRPQTRPSV--YVAIYPYTPRKEDELELRKG 469
AA G +P A ++ R QT + Y A+Y Y P+ +DELELR G
Sbjct: 1197 RGGEQAGRKAARRGGSQQPQAQQR-RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDG 1255
Query: 470 EMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV 504
++ V E+C DGWF GTS T + G FPGNYV P+
Sbjct: 1256 DIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
Score = 45.4 bits (106), Expect = 2e-04
Identities = 58/255 (22%), Positives = 99/255 (38%), Gaps = 51/255 (20%)
Query: 668 SITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSATKPDKDSKKEKKGLLKLLSGAS 727
S+ LEA+ L + T + S+ SSA P + E G + + +
Sbjct: 609 SLCQTELEAD--------LEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHA 660
Query: 728 TKRKPRVSPPASPTLEVE-------LGSAELPLQGAVGPELPPGGGHGRAGSCP---VDG 777
KR+ +P +LE E L ++PLQG G + P + P +
Sbjct: 661 VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA 720
Query: 778 DGPVTTAV---------AGAALAQDAFHRKASSLDSAVP----IAPPPRQACSS--LGPV 822
D +T Q R+ D A + P Q ++ G +
Sbjct: 721 DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDL 780
Query: 823 LN-----------ESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTL 871
LN E RP R + Q+ EL L++GDIV+++K+ + W++G
Sbjct: 781 LNIDDTAKRKSGSEMRPA-----RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG-- 833
Query: 872 QRNGKTGLFPGSFVE 886
+ +G+ G+FP +++E
Sbjct: 834 EHHGRVGIFPRTYIE 848
Score = 35.4 bits (80), Expect = 0.24
Identities = 32/118 (27%), Positives = 51/118 (43%), Gaps = 8/118 (6%)
Query: 82 KPGPGGGSGTNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWS-PPVRG--IPQLPC 138
+PG GS + A +++ + + G QQP+ Q P R L
Sbjct: 1176 RPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFS 1235
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGI--HGFFPTNFVQIIKPL 194
+ALY+Y + +L+ GDI+ + + D+ W+ G G FP N+V KPL
Sbjct: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV---KPL 1290
Score = 31.2 bits (69), Expect = 4.5
Identities = 9/45 (20%), Positives = 29/45 (64%)
Query: 844 SEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
++ E+ ++G+ + + ++ ++ W++G + + G+FP ++V+ I
Sbjct: 882 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 926
>gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens]
Length = 347
Score = 82.4 bits (202), Expect = 2e-15
Identities = 45/138 (32%), Positives = 71/138 (51%), Gaps = 24/138 (17%)
Query: 60 VEELPSNILL-VRLLDGIKQRPWKPGPGGGSGTNCTNALRSQSSTVANCSSKDLQSSQGG 118
++EL S + + + + +R +KP P ++ SS + S+ + + G
Sbjct: 233 LQELQSKLQMRISAASSVPRREYKPRP-----------VKRSSSELNGVSTTSVVKTTGS 281
Query: 119 QQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNG 178
P Q PC + LY++E + G+L F +GDII L Q+DENWY G ++G
Sbjct: 282 NIPMDQ------------PCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHG 329
Query: 179 IHGFFPTNFVQIIKPLPQ 196
GFFP N+V++I PLPQ
Sbjct: 330 ESGFFPINYVEVIVPLPQ 347
Score = 58.5 bits (140), Expect = 3e-08
Identities = 26/62 (41%), Positives = 40/62 (64%), Gaps = 4/62 (6%)
Query: 194 LPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISY 253
+P P C+ LYDFE +++ L F + D++T+ ++DENW EGM+ + G FPI+Y
Sbjct: 283 IPMDQPCCRGLYDFEPENQGE----LGFKEGDIITLTNQIDENWYEGMIHGESGFFPINY 338
Query: 254 VE 255
VE
Sbjct: 339 VE 340
Score = 42.4 bits (98), Expect = 0.002
Identities = 18/54 (33%), Positives = 36/54 (66%), Gaps = 2/54 (3%)
Query: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
R + + P+++ EL KEGDI+ + + ++ W++G + +G++G FP ++VE I
Sbjct: 291 RGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMI--HGESGFFPINYVEVI 342
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 81.6 bits (200), Expect = 3e-15
Identities = 49/173 (28%), Positives = 93/173 (53%), Gaps = 23/173 (13%)
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPP 198
A+A ++++ + +L KGDI+ + +Q+D+NWY GE +G G FP +++++ P +
Sbjct: 504 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 563
Query: 199 P------------QCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGML--AD 244
P + A ++F D + + + F K + +T++R+VDENW EG +
Sbjct: 564 PKKLTPVQVLEYGEAIAKFNFN-GDTQVE---MSFRKGERITLLRQVDENWYEGRIPGTS 619
Query: 245 KIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKK 297
+ GIFPI+YV+ + L+ K PV +D SS + ++ +P+ ++
Sbjct: 620 RQGIFPITYVDV--IKRPLV---KNPVDYMDLPFSSSPSRSATASPQQPQAQQ 667
Score = 77.4 bits (189), Expect = 5e-14
Identities = 40/104 (38%), Positives = 58/104 (55%), Gaps = 2/104 (1%)
Query: 403 PLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSV--YVAIYPYTPRK 460
PL+ V P +++ + +A P+ ++ R QT + Y A+Y Y P+
Sbjct: 635 PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQN 694
Query: 461 EDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV 504
+DELELR G++ V E+C DGWF GTS T + G FPGNYV P+
Sbjct: 695 DDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
Score = 59.3 bits (142), Expect = 2e-08
Identities = 26/53 (49%), Positives = 40/53 (75%)
Query: 834 HRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
++ + SY PQ++ ELEL++GDIV V +K +DGWF GT +R + G FPG++V+
Sbjct: 684 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736
Score = 44.3 bits (103), Expect = 5e-04
Identities = 20/63 (31%), Positives = 39/63 (61%), Gaps = 7/63 (11%)
Query: 824 NESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGS 883
+E RP R + Q+ EL L++GDIV+++K+ + W++G + +G+ G+FP +
Sbjct: 499 SEMRPA-----RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 551
Query: 884 FVE 886
++E
Sbjct: 552 YIE 554
Score = 38.9 bits (89), Expect = 0.021
Identities = 19/79 (24%), Positives = 36/79 (45%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTN 510
+A + + + E+ RKGE + + + W++G TS+ G+FP YV + R +
Sbjct: 579 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVK 638
Query: 511 ASQAKVPMSTAGQTSRGVT 529
+ + + SR T
Sbjct: 639 NPVDYMDLPFSSSPSRSAT 657
Score = 35.4 bits (80), Expect = 0.24
Identities = 12/39 (30%), Positives = 25/39 (64%), Gaps = 2/39 (5%)
Query: 463 ELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
EL L+KG++ ++++ W++G H ++G+FP Y+
Sbjct: 517 ELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 553
Score = 33.1 bits (74), Expect = 1.2
Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 5/57 (8%)
Query: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGI--HGFFPTNFVQIIKPL 194
+ALY+Y + +L+ GDI+ + + D+ W+ G G FP N+V KPL
Sbjct: 685 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV---KPL 738
Score = 31.2 bits (69), Expect = 4.5
Identities = 9/45 (20%), Positives = 29/45 (64%)
Query: 844 SEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
++ E+ ++G+ + + ++ ++ W++G + + G+FP ++V+ I
Sbjct: 588 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 632
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 81.6 bits (200), Expect = 3e-15
Identities = 49/173 (28%), Positives = 93/173 (53%), Gaps = 23/173 (13%)
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPP 198
A+A ++++ + +L KGDI+ + +Q+D+NWY GE +G G FP +++++ P +
Sbjct: 545 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 604
Query: 199 P------------QCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGML--AD 244
P + A ++F D + + + F K + +T++R+VDENW EG +
Sbjct: 605 PKKLTPVQVLEYGEAIAKFNFN-GDTQVE---MSFRKGERITLLRQVDENWYEGRIPGTS 660
Query: 245 KIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKK 297
+ GIFPI+YV+ + L+ K PV +D SS + ++ +P+ ++
Sbjct: 661 RQGIFPITYVDV--IKRPLV---KNPVDYMDLPFSSSPSRSATASPQQPQAQQ 708
Score = 77.4 bits (189), Expect = 5e-14
Identities = 40/104 (38%), Positives = 58/104 (55%), Gaps = 2/104 (1%)
Query: 403 PLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSV--YVAIYPYTPRK 460
PL+ V P +++ + +A P+ ++ R QT + Y A+Y Y P+
Sbjct: 676 PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQN 735
Query: 461 EDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV 504
+DELELR G++ V E+C DGWF GTS T + G FPGNYV P+
Sbjct: 736 DDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
Score = 59.3 bits (142), Expect = 2e-08
Identities = 26/53 (49%), Positives = 40/53 (75%)
Query: 834 HRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
++ + SY PQ++ ELEL++GDIV V +K +DGWF GT +R + G FPG++V+
Sbjct: 725 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777
Score = 44.3 bits (103), Expect = 5e-04
Identities = 20/63 (31%), Positives = 39/63 (61%), Gaps = 7/63 (11%)
Query: 824 NESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGS 883
+E RP R + Q+ EL L++GDIV+++K+ + W++G + +G+ G+FP +
Sbjct: 540 SEMRPA-----RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 592
Query: 884 FVE 886
++E
Sbjct: 593 YIE 595
Score = 38.9 bits (89), Expect = 0.021
Identities = 19/79 (24%), Positives = 36/79 (45%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTN 510
+A + + + E+ RKGE + + + W++G TS+ G+FP YV + R +
Sbjct: 620 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVK 679
Query: 511 ASQAKVPMSTAGQTSRGVT 529
+ + + SR T
Sbjct: 680 NPVDYMDLPFSSSPSRSAT 698
Score = 35.4 bits (80), Expect = 0.24
Identities = 12/39 (30%), Positives = 25/39 (64%), Gaps = 2/39 (5%)
Query: 463 ELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
EL L+KG++ ++++ W++G H ++G+FP Y+
Sbjct: 558 ELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 594
Score = 33.1 bits (74), Expect = 1.2
Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 5/57 (8%)
Query: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGI--HGFFPTNFVQIIKPL 194
+ALY+Y + +L+ GDI+ + + D+ W+ G G FP N+V KPL
Sbjct: 726 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV---KPL 779
Score = 31.2 bits (69), Expect = 4.5
Identities = 9/45 (20%), Positives = 29/45 (64%)
Query: 844 SEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
++ E+ ++G+ + + ++ ++ W++G + + G+FP ++V+ I
Sbjct: 629 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 673
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 81.6 bits (200), Expect = 3e-15
Identities = 50/169 (29%), Positives = 92/169 (54%), Gaps = 23/169 (13%)
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPP 198
A+A ++++ + +L KGDI+ + +Q+D+NWY GE +G G FP +++++ P +
Sbjct: 649 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 708
Query: 199 P------------QCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGML--AD 244
P + A ++F D + + + F K + +T++R+VDENW EG +
Sbjct: 709 PKKLTPVQVLEYGEAIAKFNFN-GDTQVE---MSFRKGERITLLRQVDENWYEGRIPGTS 764
Query: 245 KIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHS 293
+ GIFPI+YV+ + L+ K PV +D SS + ++ +P+ S
Sbjct: 765 RQGIFPITYVDV--IKRPLV---KNPVDYMDLPFSSSPSRSATASPQLS 808
Score = 74.3 bits (181), Expect = 5e-13
Identities = 31/55 (56%), Positives = 39/55 (70%)
Query: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV 504
Y A+Y Y P+ +DELELR G++ V E+C DGWF GTS T + G FPGNYV P+
Sbjct: 849 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 903
Score = 59.3 bits (142), Expect = 2e-08
Identities = 26/53 (49%), Positives = 40/53 (75%)
Query: 834 HRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
++ + SY PQ++ ELEL++GDIV V +K +DGWF GT +R + G FPG++V+
Sbjct: 849 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 901
Score = 44.3 bits (103), Expect = 5e-04
Identities = 20/63 (31%), Positives = 39/63 (61%), Gaps = 7/63 (11%)
Query: 824 NESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGS 883
+E RP R + Q+ EL L++GDIV+++K+ + W++G + +G+ G+FP +
Sbjct: 644 SEMRPA-----RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 696
Query: 884 FVE 886
++E
Sbjct: 697 YIE 699
Score = 38.9 bits (89), Expect = 0.021
Identities = 19/79 (24%), Positives = 36/79 (45%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTN 510
+A + + + E+ RKGE + + + W++G TS+ G+FP YV + R +
Sbjct: 724 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVK 783
Query: 511 ASQAKVPMSTAGQTSRGVT 529
+ + + SR T
Sbjct: 784 NPVDYMDLPFSSSPSRSAT 802
Score = 35.4 bits (80), Expect = 0.24
Identities = 12/39 (30%), Positives = 25/39 (64%), Gaps = 2/39 (5%)
Query: 463 ELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
EL L+KG++ ++++ W++G H ++G+FP Y+
Sbjct: 662 ELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 698
Score = 33.1 bits (74), Expect = 1.2
Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 5/57 (8%)
Query: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGI--HGFFPTNFVQIIKPL 194
+ALY+Y + +L+ GDI+ + + D+ W+ G G FP N+V KPL
Sbjct: 850 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV---KPL 903
Score = 31.2 bits (69), Expect = 4.5
Identities = 9/45 (20%), Positives = 29/45 (64%)
Query: 844 SEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
++ E+ ++G+ + + ++ ++ W++G + + G+FP ++V+ I
Sbjct: 733 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 777
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 81.6 bits (200), Expect = 3e-15
Identities = 49/173 (28%), Positives = 93/173 (53%), Gaps = 23/173 (13%)
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPP 198
A+A ++++ + +L KGDI+ + +Q+D+NWY GE +G G FP +++++ P +
Sbjct: 580 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 639
Query: 199 P------------QCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGML--AD 244
P + A ++F D + + + F K + +T++R+VDENW EG +
Sbjct: 640 PKKLTPVQVLEYGEAIAKFNFN-GDTQVE---MSFRKGERITLLRQVDENWYEGRIPGTS 695
Query: 245 KIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKK 297
+ GIFPI+YV+ + L+ K PV +D SS + ++ +P+ ++
Sbjct: 696 RQGIFPITYVDV--IKRPLV---KNPVDYMDLPFSSSPSRSATASPQQPQAQQ 743
Score = 77.4 bits (189), Expect = 5e-14
Identities = 40/104 (38%), Positives = 58/104 (55%), Gaps = 2/104 (1%)
Query: 403 PLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSV--YVAIYPYTPRK 460
PL+ V P +++ + +A P+ ++ R QT + Y A+Y Y P+
Sbjct: 711 PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQN 770
Query: 461 EDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV 504
+DELELR G++ V E+C DGWF GTS T + G FPGNYV P+
Sbjct: 771 DDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
Score = 59.3 bits (142), Expect = 2e-08
Identities = 26/53 (49%), Positives = 40/53 (75%)
Query: 834 HRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
++ + SY PQ++ ELEL++GDIV V +K +DGWF GT +R + G FPG++V+
Sbjct: 760 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 812
Score = 46.6 bits (109), Expect = 1e-04
Identities = 44/191 (23%), Positives = 77/191 (40%), Gaps = 41/191 (21%)
Query: 703 SSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSPPASPTLEVE-------LGSAELPLQG 755
SSA P + E G + + + KR+ +P +LE E L ++PLQG
Sbjct: 474 SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQG 533
Query: 756 AVGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQA 815
G + P + D + P A + + F R+
Sbjct: 534 LSGLKRPSSSASTK------DSESPRHFIPADYLESTEEFIRRRHDD------------- 574
Query: 816 CSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNG 875
E RP R + Q+ EL L++GDIV+++K+ + W++G + +G
Sbjct: 575 --------KEMRPA-----RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHG 619
Query: 876 KTGLFPGSFVE 886
+ G+FP +++E
Sbjct: 620 RVGIFPRTYIE 630
Score = 38.9 bits (89), Expect = 0.021
Identities = 19/79 (24%), Positives = 36/79 (45%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTN 510
+A + + + E+ RKGE + + + W++G TS+ G+FP YV + R +
Sbjct: 655 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVK 714
Query: 511 ASQAKVPMSTAGQTSRGVT 529
+ + + SR T
Sbjct: 715 NPVDYMDLPFSSSPSRSAT 733
Score = 37.0 bits (84), Expect = 0.081
Identities = 56/238 (23%), Positives = 91/238 (38%), Gaps = 35/238 (14%)
Query: 270 PVPGVDAGECSSAAAQSSTAP-KHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISP 328
P+P + SS+ P K DT+K + S KSS + + S ISP
Sbjct: 421 PLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEY-QPGKSSVLTNEKMSSAISP 479
Query: 329 PVLISSSNP--TAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPSDV 386
ISS P ++ + S AP + T L V G D+
Sbjct: 480 TPEISSETPGYIYSSNFHAVKRESDGAPGDL----TSLENERQIYKSVLEG------GDI 529
Query: 387 PYQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLR---P 443
P Q G L P A+T + +P P ST++ R
Sbjct: 530 PLQGLSG-----LKRPSSSASTKDSESPRHFI---------PADYLESTEEFIRRRHDDK 575
Query: 444 QTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
+ RP+ A + + + EL L+KG++ ++++ W++G H ++G+FP Y+
Sbjct: 576 EMRPAR--AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 629
Score = 33.1 bits (74), Expect = 1.2
Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 5/57 (8%)
Query: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGI--HGFFPTNFVQIIKPL 194
+ALY+Y + +L+ GDI+ + + D+ W+ G G FP N+V KPL
Sbjct: 761 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV---KPL 814
Score = 31.2 bits (69), Expect = 4.5
Identities = 9/45 (20%), Positives = 29/45 (64%)
Query: 844 SEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
++ E+ ++G+ + + ++ ++ W++G + + G+FP ++V+ I
Sbjct: 664 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 708
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 81.6 bits (200), Expect = 3e-15
Identities = 49/173 (28%), Positives = 93/173 (53%), Gaps = 23/173 (13%)
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPP 198
A+A ++++ + +L KGDI+ + +Q+D+NWY GE +G G FP +++++ P +
Sbjct: 448 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 507
Query: 199 P------------QCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGML--AD 244
P + A ++F D + + + F K + +T++R+VDENW EG +
Sbjct: 508 PKKLTPVQVLEYGEAIAKFNFN-GDTQVE---MSFRKGERITLLRQVDENWYEGRIPGTS 563
Query: 245 KIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKK 297
+ GIFPI+YV+ + L+ K PV +D SS + ++ +P+ ++
Sbjct: 564 RQGIFPITYVDV--IKRPLV---KNPVDYMDLPFSSSPSRSATASPQQPQAQQ 611
Score = 77.4 bits (189), Expect = 5e-14
Identities = 40/104 (38%), Positives = 58/104 (55%), Gaps = 2/104 (1%)
Query: 403 PLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSV--YVAIYPYTPRK 460
PL+ V P +++ + +A P+ ++ R QT + Y A+Y Y P+
Sbjct: 579 PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQN 638
Query: 461 EDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV 504
+DELELR G++ V E+C DGWF GTS T + G FPGNYV P+
Sbjct: 639 DDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
Score = 59.3 bits (142), Expect = 2e-08
Identities = 26/53 (49%), Positives = 40/53 (75%)
Query: 834 HRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
++ + SY PQ++ ELEL++GDIV V +K +DGWF GT +R + G FPG++V+
Sbjct: 628 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 680
Score = 46.6 bits (109), Expect = 1e-04
Identities = 44/191 (23%), Positives = 77/191 (40%), Gaps = 41/191 (21%)
Query: 703 SSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSPPASPTLEVE-------LGSAELPLQG 755
SSA P + E G + + + KR+ +P +LE E L ++PLQG
Sbjct: 342 SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQG 401
Query: 756 AVGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQA 815
G + P + D + P A + + F R+
Sbjct: 402 LSGLKRPSSSASTK------DSESPRHFIPADYLESTEEFIRRRHDD------------- 442
Query: 816 CSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNG 875
E RP R + Q+ EL L++GDIV+++K+ + W++G + +G
Sbjct: 443 --------KEMRPA-----RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHG 487
Query: 876 KTGLFPGSFVE 886
+ G+FP +++E
Sbjct: 488 RVGIFPRTYIE 498
Score = 38.9 bits (89), Expect = 0.021
Identities = 19/79 (24%), Positives = 36/79 (45%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTN 510
+A + + + E+ RKGE + + + W++G TS+ G+FP YV + R +
Sbjct: 523 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVK 582
Query: 511 ASQAKVPMSTAGQTSRGVT 529
+ + + SR T
Sbjct: 583 NPVDYMDLPFSSSPSRSAT 601
Score = 37.0 bits (84), Expect = 0.081
Identities = 56/238 (23%), Positives = 91/238 (38%), Gaps = 35/238 (14%)
Query: 270 PVPGVDAGECSSAAAQSSTAP-KHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISP 328
P+P + SS+ P K DT+K + S KSS + + S ISP
Sbjct: 289 PLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEY-QPGKSSVLTNEKMSSAISP 347
Query: 329 PVLISSSNP--TAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPSDV 386
ISS P ++ + S AP + T L V G D+
Sbjct: 348 TPEISSETPGYIYSSNFHAVKRESDGAPGDL----TSLENERQIYKSVLEG------GDI 397
Query: 387 PYQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLR---P 443
P Q G L P A+T + +P P ST++ R
Sbjct: 398 PLQGLSG-----LKRPSSSASTKDSESPRHFI---------PADYLESTEEFIRRRHDDK 443
Query: 444 QTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
+ RP+ A + + + EL L+KG++ ++++ W++G H ++G+FP Y+
Sbjct: 444 EMRPAR--AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 497
Score = 33.1 bits (74), Expect = 1.2
Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 5/57 (8%)
Query: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGI--HGFFPTNFVQIIKPL 194
+ALY+Y + +L+ GDI+ + + D+ W+ G G FP N+V KPL
Sbjct: 629 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV---KPL 682
Score = 31.2 bits (69), Expect = 4.5
Identities = 9/45 (20%), Positives = 29/45 (64%)
Query: 844 SEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
++ E+ ++G+ + + ++ ++ W++G + + G+FP ++V+ I
Sbjct: 532 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 576
>gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens]
Length = 368
Score = 79.3 bits (194), Expect = 1e-14
Identities = 45/131 (34%), Positives = 68/131 (51%), Gaps = 26/131 (19%)
Query: 78 QRPWKPGPG----------GGSGTNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWS 127
+R +KP P G CT A + +S+ S K +++
Sbjct: 252 KREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRT------------- 298
Query: 128 PPVRGIPQL--PCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPT 185
P R +P L P KALY++E + G+L F +GD+I L Q+DENWY G ++G GFFP
Sbjct: 299 -PSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPL 357
Query: 186 NFVQIIKPLPQ 196
++V+++ PLPQ
Sbjct: 358 SYVEVLVPLPQ 368
Score = 61.6 bits (148), Expect = 3e-09
Identities = 32/61 (52%), Positives = 40/61 (65%), Gaps = 4/61 (6%)
Query: 195 PQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYV 254
P P CKALYDFE E D + L F + DV+T+ ++DENW EGML + G FP+SYV
Sbjct: 305 PLDQPSCKALYDFE---PENDGE-LGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV 360
Query: 255 E 255
E
Sbjct: 361 E 361
Score = 42.0 bits (97), Expect = 0.003
Identities = 33/111 (29%), Positives = 55/111 (49%), Gaps = 21/111 (18%)
Query: 776 DGDGPVTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHR 835
+G P TTA AA +S S PI P R S+ P+ S C +
Sbjct: 272 NGGFPCTTAPKIAA--------SSSFRSSDKPIRTPSR----SMPPLDQPS----C---K 312
Query: 836 VVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
+ + P+++ EL EGD++ + + ++ W++G L +G++G FP S+VE
Sbjct: 313 ALYDFEPENDGELGFHEGDVITLTNQIDENWYEGML--DGQSGFFPLSYVE 361
Score = 33.1 bits (74), Expect = 1.2
Identities = 17/59 (28%), Positives = 31/59 (52%), Gaps = 3/59 (5%)
Query: 443 PQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
P +PS A+Y + P + EL +G++ + + + W++G M + G FP +YV
Sbjct: 305 PLDQPSCK-ALYDFEPENDGELGFHEGDVITLTNQIDENWYEG--MLDGQSGFFPLSYV 360
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 79.0 bits (193), Expect = 2e-14
Identities = 45/142 (31%), Positives = 67/142 (47%), Gaps = 32/142 (22%)
Query: 141 ALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQ---- 196
A + Y G++ +L FS+G+IIIL+ V+E W GEV G G FP NFV+ ++ P
Sbjct: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 578
Query: 197 ------------------------PPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRR 232
P C+AL+ F + D L F + D + ++ R
Sbjct: 579 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAE----TSDDLSFKRGDRIQILER 634
Query: 233 VDENWAEGMLADKIGIFPISYV 254
+D +W G L D+ GIFP +V
Sbjct: 635 LDSDWCRGRLQDREGIFPAVFV 656
Score = 73.2 bits (178), Expect = 1e-12
Identities = 44/137 (32%), Positives = 69/137 (50%), Gaps = 18/137 (13%)
Query: 130 VRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQ 189
V +P C +AL+++ + DL F +GD I + ++D +W G + G FP FV
Sbjct: 599 VNSLPAEWC-EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFV- 656
Query: 190 IIKPLPQPPP----------QCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAE 239
+P P + KALYDF + ++D L F D++T + VD++W
Sbjct: 657 --RPCPAEAKSMLAIVPKGRKAKALYDF----RGENEDELSFKAGDIITELESVDDDWMS 710
Query: 240 GMLADKIGIFPISYVEF 256
G L K GIFP +Y++F
Sbjct: 711 GELMGKSGIFPKNYIQF 727
Score = 70.5 bits (171), Expect = 7e-12
Identities = 36/133 (27%), Positives = 69/133 (51%), Gaps = 18/133 (13%)
Query: 137 PCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQ 196
P A L+++ ++ DL + G+I+ L ++D +WY G G FP N+V++I +P+
Sbjct: 439 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 498
Query: 197 --------------PPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGML 242
+C A +++ + KD L F++ +++ + V+E WA G +
Sbjct: 499 GGNGKRECVSSHCVKGSRCVARFEYIGE----QKDELSFSEGEIIILKEYVNEEWARGEV 554
Query: 243 ADKIGIFPISYVE 255
+ GIFP+++VE
Sbjct: 555 RGRTGIFPLNFVE 567
Score = 55.5 bits (132), Expect = 2e-07
Identities = 24/60 (40%), Positives = 37/60 (61%)
Query: 133 IPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIK 192
+P+ AKALY++ G+ +L F GDII VD++W GE+ G G FP N++Q ++
Sbjct: 670 VPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQ 729
Score = 42.4 bits (98), Expect = 0.002
Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 5/85 (5%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVT- 509
VA + Y ++DEL +GE+ ++ E + W +G + G+FP N+V PV T
Sbjct: 518 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFVEPVEDYPTS 575
Query: 510 --NASQAKVPMSTAGQTSRGVTMVS 532
N KVP+ T + S + V+
Sbjct: 576 GANVLSTKVPLKTKKEDSGSNSQVN 600
Score = 40.8 bits (94), Expect = 0.006
Identities = 22/73 (30%), Positives = 33/73 (45%), Gaps = 4/73 (5%)
Query: 429 RPMAGSTDQIAHLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSM 488
RP + + P+ R + A+Y + EDEL + G++ E D W G M
Sbjct: 657 RPCPAEAKSMLAIVPKGRKAK--ALYDFRGENEDELSFKAGDIITELESVDDDWMSGELM 714
Query: 489 HTSKIGVFPGNYV 501
K G+FP NY+
Sbjct: 715 --GKSGIFPKNYI 725
Score = 39.3 bits (90), Expect = 0.016
Identities = 24/82 (29%), Positives = 44/82 (53%), Gaps = 8/82 (9%)
Query: 805 AVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKRED 864
AV + P P +A S L ++ + R + + + + ++E EL K GDI+ + +D
Sbjct: 653 AVFVRPCPAEAKSMLA-IVPKGR-----KAKALYDFRGENEDELSFKAGDIITELESVDD 706
Query: 865 GWFKGTLQRNGKTGLFPGSFVE 886
W G L GK+G+FP ++++
Sbjct: 707 DWMSGELM--GKSGIFPKNYIQ 726
Score = 38.9 bits (89), Expect = 0.021
Identities = 16/51 (31%), Positives = 29/51 (56%), Gaps = 2/51 (3%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
V ++ + + D+L L GE+ + E+ W++G ++IG+FP NYV
Sbjct: 442 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYV 490
Score = 35.4 bits (80), Expect = 0.24
Identities = 17/56 (30%), Positives = 34/56 (60%), Gaps = 3/56 (5%)
Query: 834 HRVVV-SYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
H VV+ +P + +L L G+IV++ +K + W++G + + G+FP ++V+ I
Sbjct: 440 HAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQIGIFPANYVKVI 493
Score = 35.4 bits (80), Expect = 0.24
Identities = 16/49 (32%), Positives = 30/49 (61%), Gaps = 2/49 (4%)
Query: 840 YPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
Y + + EL EG+I+ + + + W +G ++ G+TG+FP +FVE +
Sbjct: 523 YIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 569
Score = 34.7 bits (78), Expect = 0.40
Identities = 26/107 (24%), Positives = 46/107 (42%), Gaps = 17/107 (15%)
Query: 398 PLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVYV-AIYPY 456
P+ P A VL++ P T + +GS Q+ L P+ + A++ +
Sbjct: 568 PVEDYPTSGANVLSTKVPLKTK---------KEDSGSNSQVNSL-----PAEWCEALHSF 613
Query: 457 TPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAP 503
T D+L ++G+ + ER W +G + G+FP +V P
Sbjct: 614 TAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRP 658
Score = 33.1 bits (74), Expect = 1.2
Identities = 31/133 (23%), Positives = 56/133 (42%), Gaps = 17/133 (12%)
Query: 753 LQGAVGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHRKASSLDSAVPIAPPP 812
L+ V E G GR G P++ PV +D A+ L + VP+
Sbjct: 541 LKEYVNEEWARGEVRGRTGIFPLNFVEPV----------EDYPTSGANVLSTKVPLKTKK 590
Query: 813 RQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQ 872
+ S+ ++ + E + S+ ++ +L K GD + + ++ + W +G LQ
Sbjct: 591 EDSGSN-----SQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ 645
Query: 873 RNGKTGLFPGSFV 885
+ G+FP FV
Sbjct: 646 --DREGIFPAVFV 656
Score = 32.0 bits (71), Expect = 2.6
Identities = 39/158 (24%), Positives = 57/158 (36%), Gaps = 16/158 (10%)
Query: 269 PPVPGVDAGECSSA---AAQSSTAPKHSDTKKNTK--KRHSFTSLTMANKSSQASQNRHS 323
PP P V +G+ S A AA ++ S T+ K + T ++ +
Sbjct: 43 PPKPTVSSGKPSVAPKPAANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPE 102
Query: 324 MEISP-PVLISSSNPTAAAR--ISELSGLSCSAPSQV--------HISTTGLIVTPPPSS 372
+ P P LI S NP R ++E S P+ +S+ P
Sbjct: 103 LPKKPNPGLIRSVNPEIPGRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLK 162
Query: 373 PVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVL 410
PVT P S +LG P PP P+L + L
Sbjct: 163 PVTVPPRLAGASQAKAYKSLGEGPPANPPVPVLQSKPL 200
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 79.0 bits (193), Expect = 2e-14
Identities = 45/142 (31%), Positives = 67/142 (47%), Gaps = 32/142 (22%)
Query: 141 ALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQ---- 196
A + Y G++ +L FS+G+IIIL+ V+E W GEV G G FP NFV+ ++ P
Sbjct: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 614
Query: 197 ------------------------PPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRR 232
P C+AL+ F + D L F + D + ++ R
Sbjct: 615 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAE----TSDDLSFKRGDRIQILER 670
Query: 233 VDENWAEGMLADKIGIFPISYV 254
+D +W G L D+ GIFP +V
Sbjct: 671 LDSDWCRGRLQDREGIFPAVFV 692
Score = 73.2 bits (178), Expect = 1e-12
Identities = 44/137 (32%), Positives = 69/137 (50%), Gaps = 18/137 (13%)
Query: 130 VRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQ 189
V +P C +AL+++ + DL F +GD I + ++D +W G + G FP FV
Sbjct: 635 VNSLPAEWC-EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFV- 692
Query: 190 IIKPLPQPPP----------QCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAE 239
+P P + KALYDF + ++D L F D++T + VD++W
Sbjct: 693 --RPCPAEAKSMLAIVPKGRKAKALYDF----RGENEDELSFKAGDIITELESVDDDWMS 746
Query: 240 GMLADKIGIFPISYVEF 256
G L K GIFP +Y++F
Sbjct: 747 GELMGKSGIFPKNYIQF 763
Score = 70.5 bits (171), Expect = 7e-12
Identities = 36/133 (27%), Positives = 69/133 (51%), Gaps = 18/133 (13%)
Query: 137 PCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQ 196
P A L+++ ++ DL + G+I+ L ++D +WY G G FP N+V++I +P+
Sbjct: 475 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 534
Query: 197 --------------PPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGML 242
+C A +++ + KD L F++ +++ + V+E WA G +
Sbjct: 535 GGNGKRECVSSHCVKGSRCVARFEYIGE----QKDELSFSEGEIIILKEYVNEEWARGEV 590
Query: 243 ADKIGIFPISYVE 255
+ GIFP+++VE
Sbjct: 591 RGRTGIFPLNFVE 603
Score = 55.5 bits (132), Expect = 2e-07
Identities = 24/60 (40%), Positives = 37/60 (61%)
Query: 133 IPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIK 192
+P+ AKALY++ G+ +L F GDII VD++W GE+ G G FP N++Q ++
Sbjct: 706 VPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQ 765
Score = 42.4 bits (98), Expect = 0.002
Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 5/85 (5%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVT- 509
VA + Y ++DEL +GE+ ++ E + W +G + G+FP N+V PV T
Sbjct: 554 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFVEPVEDYPTS 611
Query: 510 --NASQAKVPMSTAGQTSRGVTMVS 532
N KVP+ T + S + V+
Sbjct: 612 GANVLSTKVPLKTKKEDSGSNSQVN 636
Score = 40.8 bits (94), Expect = 0.006
Identities = 22/73 (30%), Positives = 33/73 (45%), Gaps = 4/73 (5%)
Query: 429 RPMAGSTDQIAHLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSM 488
RP + + P+ R + A+Y + EDEL + G++ E D W G M
Sbjct: 693 RPCPAEAKSMLAIVPKGRKAK--ALYDFRGENEDELSFKAGDIITELESVDDDWMSGELM 750
Query: 489 HTSKIGVFPGNYV 501
K G+FP NY+
Sbjct: 751 --GKSGIFPKNYI 761
Score = 39.3 bits (90), Expect = 0.016
Identities = 24/82 (29%), Positives = 44/82 (53%), Gaps = 8/82 (9%)
Query: 805 AVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKRED 864
AV + P P +A S L ++ + R + + + + ++E EL K GDI+ + +D
Sbjct: 689 AVFVRPCPAEAKSMLA-IVPKGR-----KAKALYDFRGENEDELSFKAGDIITELESVDD 742
Query: 865 GWFKGTLQRNGKTGLFPGSFVE 886
W G L GK+G+FP ++++
Sbjct: 743 DWMSGELM--GKSGIFPKNYIQ 762
Score = 38.9 bits (89), Expect = 0.021
Identities = 16/51 (31%), Positives = 29/51 (56%), Gaps = 2/51 (3%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
V ++ + + D+L L GE+ + E+ W++G ++IG+FP NYV
Sbjct: 478 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYV 526
Score = 35.4 bits (80), Expect = 0.24
Identities = 17/56 (30%), Positives = 34/56 (60%), Gaps = 3/56 (5%)
Query: 834 HRVVV-SYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
H VV+ +P + +L L G+IV++ +K + W++G + + G+FP ++V+ I
Sbjct: 476 HAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQIGIFPANYVKVI 529
Score = 35.4 bits (80), Expect = 0.24
Identities = 16/49 (32%), Positives = 30/49 (61%), Gaps = 2/49 (4%)
Query: 840 YPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
Y + + EL EG+I+ + + + W +G ++ G+TG+FP +FVE +
Sbjct: 559 YIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 605
Score = 34.7 bits (78), Expect = 0.40
Identities = 26/107 (24%), Positives = 46/107 (42%), Gaps = 17/107 (15%)
Query: 398 PLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVYV-AIYPY 456
P+ P A VL++ P T + +GS Q+ L P+ + A++ +
Sbjct: 604 PVEDYPTSGANVLSTKVPLKTK---------KEDSGSNSQVNSL-----PAEWCEALHSF 649
Query: 457 TPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAP 503
T D+L ++G+ + ER W +G + G+FP +V P
Sbjct: 650 TAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRP 694
Score = 33.1 bits (74), Expect = 1.2
Identities = 31/133 (23%), Positives = 56/133 (42%), Gaps = 17/133 (12%)
Query: 753 LQGAVGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHRKASSLDSAVPIAPPP 812
L+ V E G GR G P++ PV +D A+ L + VP+
Sbjct: 577 LKEYVNEEWARGEVRGRTGIFPLNFVEPV----------EDYPTSGANVLSTKVPLKTKK 626
Query: 813 RQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQ 872
+ S+ ++ + E + S+ ++ +L K GD + + ++ + W +G LQ
Sbjct: 627 EDSGSN-----SQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ 681
Query: 873 RNGKTGLFPGSFV 885
+ G+FP FV
Sbjct: 682 --DREGIFPAVFV 692
Score = 32.0 bits (71), Expect = 2.6
Identities = 39/158 (24%), Positives = 57/158 (36%), Gaps = 16/158 (10%)
Query: 269 PPVPGVDAGECSSA---AAQSSTAPKHSDTKKNTK--KRHSFTSLTMANKSSQASQNRHS 323
PP P V +G+ S A AA ++ S T+ K + T ++ +
Sbjct: 43 PPKPTVSSGKPSVAPKPAANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPE 102
Query: 324 MEISP-PVLISSSNPTAAAR--ISELSGLSCSAPSQV--------HISTTGLIVTPPPSS 372
+ P P LI S NP R ++E S P+ +S+ P
Sbjct: 103 LPKKPNPGLIRSVNPEIPGRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLK 162
Query: 373 PVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVL 410
PVT P S +LG P PP P+L + L
Sbjct: 163 PVTVPPRLAGASQAKAYKSLGEGPPANPPVPVLQSKPL 200
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 79.0 bits (193), Expect = 2e-14
Identities = 45/142 (31%), Positives = 67/142 (47%), Gaps = 32/142 (22%)
Query: 141 ALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQ---- 196
A + Y G++ +L FS+G+IIIL+ V+E W GEV G G FP NFV+ ++ P
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 637
Query: 197 ------------------------PPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRR 232
P C+AL+ F + D L F + D + ++ R
Sbjct: 638 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAE----TSDDLSFKRGDRIQILER 693
Query: 233 VDENWAEGMLADKIGIFPISYV 254
+D +W G L D+ GIFP +V
Sbjct: 694 LDSDWCRGRLQDREGIFPAVFV 715
Score = 73.2 bits (178), Expect = 1e-12
Identities = 44/137 (32%), Positives = 69/137 (50%), Gaps = 18/137 (13%)
Query: 130 VRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQ 189
V +P C +AL+++ + DL F +GD I + ++D +W G + G FP FV
Sbjct: 658 VNSLPAEWC-EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFV- 715
Query: 190 IIKPLPQPPP----------QCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAE 239
+P P + KALYDF + ++D L F D++T + VD++W
Sbjct: 716 --RPCPAEAKSMLAIVPKGRKAKALYDF----RGENEDELSFKAGDIITELESVDDDWMS 769
Query: 240 GMLADKIGIFPISYVEF 256
G L K GIFP +Y++F
Sbjct: 770 GELMGKSGIFPKNYIQF 786
Score = 70.5 bits (171), Expect = 7e-12
Identities = 36/133 (27%), Positives = 69/133 (51%), Gaps = 18/133 (13%)
Query: 137 PCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQ 196
P A L+++ ++ DL + G+I+ L ++D +WY G G FP N+V++I +P+
Sbjct: 498 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 557
Query: 197 --------------PPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGML 242
+C A +++ + KD L F++ +++ + V+E WA G +
Sbjct: 558 GGNGKRECVSSHCVKGSRCVARFEYIGE----QKDELSFSEGEIIILKEYVNEEWARGEV 613
Query: 243 ADKIGIFPISYVE 255
+ GIFP+++VE
Sbjct: 614 RGRTGIFPLNFVE 626
Score = 55.5 bits (132), Expect = 2e-07
Identities = 24/60 (40%), Positives = 37/60 (61%)
Query: 133 IPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIK 192
+P+ AKALY++ G+ +L F GDII VD++W GE+ G G FP N++Q ++
Sbjct: 729 VPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQ 788
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/126 (23%), Positives = 58/126 (46%), Gaps = 22/126 (17%)
Query: 148 KEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPL-------PQPP-- 198
+ PG+L +GD++++ +Q + N+ + G + ++II PL P P
Sbjct: 429 QNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSH 488
Query: 199 ---------PQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIF 249
P L+DF + D L +++ ++ ++D +W G ++IGIF
Sbjct: 489 AQKPVDSGAPHAVVLHDFPAE----QVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIF 544
Query: 250 PISYVE 255
P +YV+
Sbjct: 545 PANYVK 550
Score = 42.4 bits (98), Expect = 0.002
Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 5/85 (5%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVT- 509
VA + Y ++DEL +GE+ ++ E + W +G + G+FP N+V PV T
Sbjct: 577 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFVEPVEDYPTS 634
Query: 510 --NASQAKVPMSTAGQTSRGVTMVS 532
N KVP+ T + S + V+
Sbjct: 635 GANVLSTKVPLKTKKEDSGSNSQVN 659
Score = 40.8 bits (94), Expect = 0.006
Identities = 22/73 (30%), Positives = 33/73 (45%), Gaps = 4/73 (5%)
Query: 429 RPMAGSTDQIAHLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSM 488
RP + + P+ R + A+Y + EDEL + G++ E D W G M
Sbjct: 716 RPCPAEAKSMLAIVPKGRKAK--ALYDFRGENEDELSFKAGDIITELESVDDDWMSGELM 773
Query: 489 HTSKIGVFPGNYV 501
K G+FP NY+
Sbjct: 774 --GKSGIFPKNYI 784
Score = 39.3 bits (90), Expect = 0.016
Identities = 24/82 (29%), Positives = 44/82 (53%), Gaps = 8/82 (9%)
Query: 805 AVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKRED 864
AV + P P +A S L ++ + R + + + + ++E EL K GDI+ + +D
Sbjct: 712 AVFVRPCPAEAKSMLA-IVPKGR-----KAKALYDFRGENEDELSFKAGDIITELESVDD 765
Query: 865 GWFKGTLQRNGKTGLFPGSFVE 886
W G L GK+G+FP ++++
Sbjct: 766 DWMSGELM--GKSGIFPKNYIQ 785
Score = 38.9 bits (89), Expect = 0.021
Identities = 16/51 (31%), Positives = 29/51 (56%), Gaps = 2/51 (3%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
V ++ + + D+L L GE+ + E+ W++G ++IG+FP NYV
Sbjct: 501 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYV 549
Score = 35.4 bits (80), Expect = 0.24
Identities = 17/56 (30%), Positives = 34/56 (60%), Gaps = 3/56 (5%)
Query: 834 HRVVV-SYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
H VV+ +P + +L L G+IV++ +K + W++G + + G+FP ++V+ I
Sbjct: 499 HAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQIGIFPANYVKVI 552
Score = 35.4 bits (80), Expect = 0.24
Identities = 16/49 (32%), Positives = 30/49 (61%), Gaps = 2/49 (4%)
Query: 840 YPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
Y + + EL EG+I+ + + + W +G ++ G+TG+FP +FVE +
Sbjct: 582 YIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 628
Score = 34.7 bits (78), Expect = 0.40
Identities = 26/107 (24%), Positives = 46/107 (42%), Gaps = 17/107 (15%)
Query: 398 PLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVYV-AIYPY 456
P+ P A VL++ P T + +GS Q+ L P+ + A++ +
Sbjct: 627 PVEDYPTSGANVLSTKVPLKTK---------KEDSGSNSQVNSL-----PAEWCEALHSF 672
Query: 457 TPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAP 503
T D+L ++G+ + ER W +G + G+FP +V P
Sbjct: 673 TAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRP 717
Score = 33.1 bits (74), Expect = 1.2
Identities = 31/133 (23%), Positives = 56/133 (42%), Gaps = 17/133 (12%)
Query: 753 LQGAVGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHRKASSLDSAVPIAPPP 812
L+ V E G GR G P++ PV +D A+ L + VP+
Sbjct: 600 LKEYVNEEWARGEVRGRTGIFPLNFVEPV----------EDYPTSGANVLSTKVPLKTKK 649
Query: 813 RQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQ 872
+ S+ ++ + E + S+ ++ +L K GD + + ++ + W +G LQ
Sbjct: 650 EDSGSN-----SQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ 704
Query: 873 RNGKTGLFPGSFV 885
+ G+FP FV
Sbjct: 705 --DREGIFPAVFV 715
Score = 32.0 bits (71), Expect = 2.6
Identities = 39/158 (24%), Positives = 57/158 (36%), Gaps = 16/158 (10%)
Query: 269 PPVPGVDAGECSSA---AAQSSTAPKHSDTKKNTK--KRHSFTSLTMANKSSQASQNRHS 323
PP P V +G+ S A AA ++ S T+ K + T ++ +
Sbjct: 43 PPKPTVSSGKPSVAPKPAANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPE 102
Query: 324 MEISP-PVLISSSNPTAAAR--ISELSGLSCSAPSQV--------HISTTGLIVTPPPSS 372
+ P P LI S NP R ++E S P+ +S+ P
Sbjct: 103 LPKKPNPGLIRSVNPEIPGRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLK 162
Query: 373 PVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVL 410
PVT P S +LG P PP P+L + L
Sbjct: 163 PVTVPPRLAGASQAKAYKSLGEGPPANPPVPVLQSKPL 200
>gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens]
Length = 352
Score = 75.1 bits (183), Expect = 3e-13
Identities = 31/59 (52%), Positives = 43/59 (72%)
Query: 137 PCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLP 195
PC +ALY++E + G+L F +GDII L Q+DENWY G ++G GFFP N+V+I+ LP
Sbjct: 293 PCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALP 351
Score = 57.4 bits (137), Expect = 6e-08
Identities = 27/57 (47%), Positives = 38/57 (66%), Gaps = 4/57 (7%)
Query: 199 PQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVE 255
P C+ALYDFE +++ L F + D++T+ ++DENW EGML G FPI+YVE
Sbjct: 293 PCCRALYDFEPENEGE----LGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVE 345
Score = 44.3 bits (103), Expect = 5e-04
Identities = 19/52 (36%), Positives = 34/52 (65%), Gaps = 2/52 (3%)
Query: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
R + + P++E EL KEGDI+ + + ++ W++G L +G +G FP ++VE
Sbjct: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGML--HGHSGFFPINYVE 345
Score = 35.4 bits (80), Expect = 0.24
Identities = 16/50 (32%), Positives = 27/50 (54%), Gaps = 2/50 (4%)
Query: 452 AIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
A+Y + P E EL ++G++ + + + W++G M G FP NYV
Sbjct: 297 ALYDFEPENEGELGFKEGDIITLTNQIDENWYEG--MLHGHSGFFPINYV 344
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 70.5 bits (171), Expect = 7e-12
Identities = 54/176 (30%), Positives = 82/176 (46%), Gaps = 26/176 (14%)
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPP 198
A+AL ++ K+ L FSK DII + Q ENW+ GEV+G G+FP ++V+II
Sbjct: 876 AQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKR 934
Query: 199 PQCKALYDFEVKD------------------KEADKDCLPFAKDDVLTVIRRVDENWAEG 240
+ +ALY K + L F + + + V ++ D W G
Sbjct: 935 EEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTG 993
Query: 241 MLADKIGIFPISYVE------FNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAP 290
+ D+ GIFP +YV+ F SA+K KP + V + +S + Q S AP
Sbjct: 994 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAP 1049
Score = 55.5 bits (132), Expect = 2e-07
Identities = 35/145 (24%), Positives = 70/145 (48%), Gaps = 18/145 (12%)
Query: 134 PQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGI-----HGFFPTNFV 188
P++ + Y G E L + G +I++ ++ W+ GE+ G+FP + V
Sbjct: 1028 PEIAQVTSAYVASGSE--QLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1085
Query: 189 QIIKP-----LPQPPPQCK--ALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGM 241
+++ P P P C+ A+YD+ ++ D L F+K ++ V+ + D +W +G
Sbjct: 1086 KLLGPSSERATPAFHPVCQVIAMYDYAANNE----DELSFSKGQLINVMNKDDPDWWQGE 1141
Query: 242 LADKIGIFPISYVEFNSAAKQLIEW 266
+ G+FP +YV+ + + +W
Sbjct: 1142 INGVTGLFPSNYVKMTTDSDPSQQW 1166
Score = 40.8 bits (94), Expect = 0.006
Identities = 21/56 (37%), Positives = 31/56 (55%), Gaps = 10/56 (17%)
Query: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDEN------WYHGEVNGIHGFFPTNFVQ 189
+ALY +E + ++ F+ GDII QVDE W +G G G+FP N+V+
Sbjct: 736 RALYPFEARNHDEMSFNSGDII----QVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 787
Score = 40.4 bits (93), Expect = 0.007
Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 3/54 (5%)
Query: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAP 503
Y+A+YPY+ + +L +GE LV ++ + W T + G+FP NYV P
Sbjct: 959 YIALYPYSSVEPGDLTFTEGEEILVTQKDGEWW---TGSIGDRSGIFPSNYVKP 1009
Score = 40.0 bits (92), Expect = 0.010
Identities = 39/147 (26%), Positives = 57/147 (38%), Gaps = 8/147 (5%)
Query: 450 YVAIYPYTPRKEDELELRKGEMFLVFERC--QDGWFKGTSMHTSKIGVFPGNYV--APVT 505
Y A+YP+ R DE+ G++ V E+ + GW G+ G FP NYV P +
Sbjct: 735 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGS--FQGNFGWFPCNYVEKMPSS 792
Query: 506 RAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNGVAGSPSVVPAA--VVSAA 563
S K + S T P ++ PA V+ S V + SA
Sbjct: 793 ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAF 852
Query: 564 HIQTSPQAKVLLHMTGQMTVNQARNAV 590
SP + +H GQ+ N A+
Sbjct: 853 TRTVSPGSVSPIHGQGQVVENLKAQAL 879
Score = 39.7 bits (91), Expect = 0.013
Identities = 23/77 (29%), Positives = 37/77 (48%), Gaps = 4/77 (5%)
Query: 812 PRQACSSLGPVLNESRPVVCERHRVVV--SYPPQSEAELELKEGDIVFVHKKREDGWFKG 869
P LGP + P +V+ Y +E EL +G ++ V K + W++G
Sbjct: 1081 PASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG 1140
Query: 870 TLQRNGKTGLFPGSFVE 886
+ NG TGLFP ++V+
Sbjct: 1141 EI--NGVTGLFPSNYVK 1155
Score = 39.7 bits (91), Expect = 0.013
Identities = 19/55 (34%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505
+A+Y Y EDEL KG++ V + W++G G+FP NYV T
Sbjct: 1106 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEI--NGVTGLFPSNYVKMTT 1158
Score = 38.5 bits (88), Expect = 0.028
Identities = 19/55 (34%), Positives = 28/55 (50%), Gaps = 3/55 (5%)
Query: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGK---TGLFPGSFVE 886
+V +Y +L L G ++ + KK GW++G LQ GK G FP S V+
Sbjct: 1032 QVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVK 1086
Score = 31.2 bits (69), Expect = 4.5
Identities = 33/134 (24%), Positives = 58/134 (43%), Gaps = 18/134 (13%)
Query: 202 KALYDFEVKDKEADKDCLPFAKDDVLTVIRRV--DENWAEGMLADKIGIFPISYVEF--N 257
+ALY FE ++ D + F D++ V + + W G G FP +YVE +
Sbjct: 736 RALYPFEARNH----DEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPS 791
Query: 258 SAAKQLIEWDK---PPVPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKS 314
S ++ + K PP + A SS S+ +D + SF++LT+ +
Sbjct: 792 SENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTD-----YQNVSFSNLTV--NT 844
Query: 315 SQASQNRHSMEISP 328
S ++ + +SP
Sbjct: 845 SWQKKSAFTRTVSP 858
Score = 31.2 bits (69), Expect = 4.5
Identities = 18/71 (25%), Positives = 38/71 (53%), Gaps = 3/71 (4%)
Query: 818 SLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKT 877
S+ P+ + + V + + + S+ + + L + DI+ V +++E+ WF + +G
Sbjct: 860 SVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFG---EVHGGR 916
Query: 878 GLFPGSFVENI 888
G FP S+V+ I
Sbjct: 917 GWFPKSYVKII 927
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 70.5 bits (171), Expect = 7e-12
Identities = 54/176 (30%), Positives = 82/176 (46%), Gaps = 26/176 (14%)
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPP 198
A+AL ++ K+ L FSK DII + Q ENW+ GEV+G G+FP ++V+II
Sbjct: 903 AQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKR 961
Query: 199 PQCKALYDFEVKD------------------KEADKDCLPFAKDDVLTVIRRVDENWAEG 240
+ +ALY K + L F + + + V ++ D W G
Sbjct: 962 EEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTG 1020
Query: 241 MLADKIGIFPISYVE------FNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAP 290
+ D+ GIFP +YV+ F SA+K KP + V + +S + Q S AP
Sbjct: 1021 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAP 1076
Score = 55.5 bits (132), Expect = 2e-07
Identities = 35/145 (24%), Positives = 70/145 (48%), Gaps = 18/145 (12%)
Query: 134 PQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGI-----HGFFPTNFV 188
P++ + Y G E L + G +I++ ++ W+ GE+ G+FP + V
Sbjct: 1055 PEIAQVTSAYVASGSE--QLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1112
Query: 189 QIIKP-----LPQPPPQCK--ALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGM 241
+++ P P P C+ A+YD+ ++ D L F+K ++ V+ + D +W +G
Sbjct: 1113 KLLGPSSERATPAFHPVCQVIAMYDYAANNE----DELSFSKGQLINVMNKDDPDWWQGE 1168
Query: 242 LADKIGIFPISYVEFNSAAKQLIEW 266
+ G+FP +YV+ + + +W
Sbjct: 1169 INGVTGLFPSNYVKMTTDSDPSQQW 1193
Score = 40.8 bits (94), Expect = 0.006
Identities = 21/56 (37%), Positives = 31/56 (55%), Gaps = 10/56 (17%)
Query: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDEN------WYHGEVNGIHGFFPTNFVQ 189
+ALY +E + ++ F+ GDII QVDE W +G G G+FP N+V+
Sbjct: 763 RALYPFEARNHDEMSFNSGDII----QVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 814
Score = 40.4 bits (93), Expect = 0.007
Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 3/54 (5%)
Query: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAP 503
Y+A+YPY+ + +L +GE LV ++ + W T + G+FP NYV P
Sbjct: 986 YIALYPYSSVEPGDLTFTEGEEILVTQKDGEWW---TGSIGDRSGIFPSNYVKP 1036
Score = 40.0 bits (92), Expect = 0.010
Identities = 39/147 (26%), Positives = 57/147 (38%), Gaps = 8/147 (5%)
Query: 450 YVAIYPYTPRKEDELELRKGEMFLVFERC--QDGWFKGTSMHTSKIGVFPGNYV--APVT 505
Y A+YP+ R DE+ G++ V E+ + GW G+ G FP NYV P +
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGS--FQGNFGWFPCNYVEKMPSS 819
Query: 506 RAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNGVAGSPSVVPAA--VVSAA 563
S K + S T P ++ PA V+ S V + SA
Sbjct: 820 ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAF 879
Query: 564 HIQTSPQAKVLLHMTGQMTVNQARNAV 590
SP + +H GQ+ N A+
Sbjct: 880 TRTVSPGSVSPIHGQGQVVENLKAQAL 906
Score = 39.7 bits (91), Expect = 0.013
Identities = 23/77 (29%), Positives = 37/77 (48%), Gaps = 4/77 (5%)
Query: 812 PRQACSSLGPVLNESRPVVCERHRVVV--SYPPQSEAELELKEGDIVFVHKKREDGWFKG 869
P LGP + P +V+ Y +E EL +G ++ V K + W++G
Sbjct: 1108 PASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG 1167
Query: 870 TLQRNGKTGLFPGSFVE 886
+ NG TGLFP ++V+
Sbjct: 1168 EI--NGVTGLFPSNYVK 1182
Score = 39.7 bits (91), Expect = 0.013
Identities = 19/55 (34%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505
+A+Y Y EDEL KG++ V + W++G G+FP NYV T
Sbjct: 1133 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEI--NGVTGLFPSNYVKMTT 1185
Score = 38.5 bits (88), Expect = 0.028
Identities = 19/55 (34%), Positives = 28/55 (50%), Gaps = 3/55 (5%)
Query: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGK---TGLFPGSFVE 886
+V +Y +L L G ++ + KK GW++G LQ GK G FP S V+
Sbjct: 1059 QVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVK 1113
Score = 31.2 bits (69), Expect = 4.5
Identities = 33/134 (24%), Positives = 58/134 (43%), Gaps = 18/134 (13%)
Query: 202 KALYDFEVKDKEADKDCLPFAKDDVLTVIRRV--DENWAEGMLADKIGIFPISYVEF--N 257
+ALY FE ++ D + F D++ V + + W G G FP +YVE +
Sbjct: 763 RALYPFEARNH----DEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPS 818
Query: 258 SAAKQLIEWDK---PPVPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKS 314
S ++ + K PP + A SS S+ +D + SF++LT+ +
Sbjct: 819 SENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTD-----YQNVSFSNLTV--NT 871
Query: 315 SQASQNRHSMEISP 328
S ++ + +SP
Sbjct: 872 SWQKKSAFTRTVSP 885
Score = 31.2 bits (69), Expect = 4.5
Identities = 18/71 (25%), Positives = 38/71 (53%), Gaps = 3/71 (4%)
Query: 818 SLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKT 877
S+ P+ + + V + + + S+ + + L + DI+ V +++E+ WF + +G
Sbjct: 887 SVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFG---EVHGGR 943
Query: 878 GLFPGSFVENI 888
G FP S+V+ I
Sbjct: 944 GWFPKSYVKII 954
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 70.5 bits (171), Expect = 7e-12
Identities = 54/176 (30%), Positives = 82/176 (46%), Gaps = 26/176 (14%)
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPP 198
A+AL ++ K+ L FSK DII + Q ENW+ GEV+G G+FP ++V+II
Sbjct: 903 AQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKR 961
Query: 199 PQCKALYDFEVKD------------------KEADKDCLPFAKDDVLTVIRRVDENWAEG 240
+ +ALY K + L F + + + V ++ D W G
Sbjct: 962 EEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTG 1020
Query: 241 MLADKIGIFPISYVE------FNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAP 290
+ D+ GIFP +YV+ F SA+K KP + V + +S + Q S AP
Sbjct: 1021 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAP 1076
Score = 55.5 bits (132), Expect = 2e-07
Identities = 35/145 (24%), Positives = 70/145 (48%), Gaps = 18/145 (12%)
Query: 134 PQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGI-----HGFFPTNFV 188
P++ + Y G E L + G +I++ ++ W+ GE+ G+FP + V
Sbjct: 1055 PEIAQVTSAYVASGSE--QLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1112
Query: 189 QIIKP-----LPQPPPQCK--ALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGM 241
+++ P P P C+ A+YD+ ++ D L F+K ++ V+ + D +W +G
Sbjct: 1113 KLLGPSSERATPAFHPVCQVIAMYDYAANNE----DELSFSKGQLINVMNKDDPDWWQGE 1168
Query: 242 LADKIGIFPISYVEFNSAAKQLIEW 266
+ G+FP +YV+ + + +W
Sbjct: 1169 INGVTGLFPSNYVKMTTDSDPSQQW 1193
Score = 40.8 bits (94), Expect = 0.006
Identities = 21/56 (37%), Positives = 31/56 (55%), Gaps = 10/56 (17%)
Query: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDEN------WYHGEVNGIHGFFPTNFVQ 189
+ALY +E + ++ F+ GDII QVDE W +G G G+FP N+V+
Sbjct: 763 RALYPFEARNHDEMSFNSGDII----QVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 814
Score = 40.4 bits (93), Expect = 0.007
Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 3/54 (5%)
Query: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAP 503
Y+A+YPY+ + +L +GE LV ++ + W T + G+FP NYV P
Sbjct: 986 YIALYPYSSVEPGDLTFTEGEEILVTQKDGEWW---TGSIGDRSGIFPSNYVKP 1036
Score = 40.0 bits (92), Expect = 0.010
Identities = 39/147 (26%), Positives = 57/147 (38%), Gaps = 8/147 (5%)
Query: 450 YVAIYPYTPRKEDELELRKGEMFLVFERC--QDGWFKGTSMHTSKIGVFPGNYV--APVT 505
Y A+YP+ R DE+ G++ V E+ + GW G+ G FP NYV P +
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGS--FQGNFGWFPCNYVEKMPSS 819
Query: 506 RAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNGVAGSPSVVPAA--VVSAA 563
S K + S T P ++ PA V+ S V + SA
Sbjct: 820 ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAF 879
Query: 564 HIQTSPQAKVLLHMTGQMTVNQARNAV 590
SP + +H GQ+ N A+
Sbjct: 880 TRTVSPGSVSPIHGQGQVVENLKAQAL 906
Score = 39.7 bits (91), Expect = 0.013
Identities = 23/77 (29%), Positives = 37/77 (48%), Gaps = 4/77 (5%)
Query: 812 PRQACSSLGPVLNESRPVVCERHRVVV--SYPPQSEAELELKEGDIVFVHKKREDGWFKG 869
P LGP + P +V+ Y +E EL +G ++ V K + W++G
Sbjct: 1108 PASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG 1167
Query: 870 TLQRNGKTGLFPGSFVE 886
+ NG TGLFP ++V+
Sbjct: 1168 EI--NGVTGLFPSNYVK 1182
Score = 39.7 bits (91), Expect = 0.013
Identities = 19/55 (34%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505
+A+Y Y EDEL KG++ V + W++G G+FP NYV T
Sbjct: 1133 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEI--NGVTGLFPSNYVKMTT 1185
Score = 38.5 bits (88), Expect = 0.028
Identities = 19/55 (34%), Positives = 28/55 (50%), Gaps = 3/55 (5%)
Query: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGK---TGLFPGSFVE 886
+V +Y +L L G ++ + KK GW++G LQ GK G FP S V+
Sbjct: 1059 QVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVK 1113
Score = 31.2 bits (69), Expect = 4.5
Identities = 33/134 (24%), Positives = 58/134 (43%), Gaps = 18/134 (13%)
Query: 202 KALYDFEVKDKEADKDCLPFAKDDVLTVIRRV--DENWAEGMLADKIGIFPISYVEF--N 257
+ALY FE ++ D + F D++ V + + W G G FP +YVE +
Sbjct: 763 RALYPFEARNH----DEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPS 818
Query: 258 SAAKQLIEWDK---PPVPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKS 314
S ++ + K PP + A SS S+ +D + SF++LT+ +
Sbjct: 819 SENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTD-----YQNVSFSNLTV--NT 871
Query: 315 SQASQNRHSMEISP 328
S ++ + +SP
Sbjct: 872 SWQKKSAFTRTVSP 885
Score = 31.2 bits (69), Expect = 4.5
Identities = 18/71 (25%), Positives = 38/71 (53%), Gaps = 3/71 (4%)
Query: 818 SLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKT 877
S+ P+ + + V + + + S+ + + L + DI+ V +++E+ WF + +G
Sbjct: 887 SVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFG---EVHGGR 943
Query: 878 GLFPGSFVENI 888
G FP S+V+ I
Sbjct: 944 GWFPKSYVKII 954
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 64.3 bits (155), Expect = 5e-10
Identities = 37/147 (25%), Positives = 71/147 (48%), Gaps = 23/147 (15%)
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIH-----GFFPTNFVQIIKP 193
A+ + +Y P L + G +I++R++ W+ GE+ G+FP N+V+++ P
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
Query: 194 -----LPQPPPQCKAL---------YDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAE 239
P PP+ AL YD+ ++ D L F K ++ V+ + D +W +
Sbjct: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQND----DELAFNKGQIINVLNKEDPDWWK 1194
Query: 240 GMLADKIGIFPISYVEFNSAAKQLIEW 266
G + ++G+FP +YV+ + +W
Sbjct: 1195 GEVNGQVGLFPSNYVKLTTDMDPSQQW 1221
Score = 63.5 bits (153), Expect = 8e-10
Identities = 52/186 (27%), Positives = 84/186 (45%), Gaps = 40/186 (21%)
Query: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIK-PL--- 194
A+ALY + K+ L F+K D+I + Q D W+ GEV G G+FP ++V++I P+
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQD-MWWFGEVQGQKGWFPKSYVKLISGPIRKS 976
Query: 195 -------PQPPPQCK-----------------ALYDFEVKDKEADKDCLPFAKDDVLTVI 230
+ P K A+Y +E +++ L F + DV+ V
Sbjct: 977 TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYE----SSEQGDLTFQQGDVILVT 1032
Query: 231 RRVDENWAEGMLADKIGIFPISYVEF------NSAAKQLIEWDKPPVPGVDAGECSSAAA 284
++ D +W G + DK G+FP +YV +A K KP + V A ++
Sbjct: 1033 KK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPE 1091
Query: 285 QSSTAP 290
Q + AP
Sbjct: 1092 QLTLAP 1097
Score = 58.9 bits (141), Expect = 2e-08
Identities = 45/174 (25%), Positives = 72/174 (41%), Gaps = 21/174 (12%)
Query: 141 ALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQI---------- 190
A+Y YE E GDL F +GD+I++ ++ D +W+ G V G FP+N+V++
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 191 -IKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADK---- 245
L + P + + + E L A ++ + ++ W EG L +
Sbjct: 1068 KTGSLGKKPEIAQVIASYTATGPEQ----LTLAPGQLILIRKKNPGGWWEGELQARGKKR 1123
Query: 246 -IGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKKN 298
IG FP +YV+ S I +PP A C TA + N
Sbjct: 1124 QIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFN 1177
Score = 51.2 bits (121), Expect = 4e-06
Identities = 22/64 (34%), Positives = 37/64 (57%)
Query: 142 LYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPPPQC 201
+Y+Y + +L F+KG II + + D +W+ GEVNG G FP+N+V++ + C
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQWC 1222
Query: 202 KALY 205
L+
Sbjct: 1223 SDLH 1226
Score = 46.6 bits (109), Expect = 1e-04
Identities = 72/338 (21%), Positives = 118/338 (34%), Gaps = 73/338 (21%)
Query: 200 QCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSA 259
Q +ALY + K L F K+DV+TV+ + D W G + + G FP SYV+
Sbjct: 917 QAQALYPWRAKKDNH----LNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVK---- 967
Query: 260 AKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQ 319
LI +D+G S A+ A S K F ++ S Q
Sbjct: 968 ---LISGPIRKSTSMDSGSSESPASLKRVA---SPAAKPVVSGEEFIAMYTYESSEQGDL 1021
Query: 320 NRHSMEISPPVLISSSN---------------PTAAARISELSGLSCSAPSQVHISTTGL 364
++ +L++ + P+ R+ + G + TG
Sbjct: 1022 TFQQGDV---ILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGK-------TGS 1071
Query: 365 IVTPPPSSPVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAA 424
+ P + V + T P + L P L+ ++ PG
Sbjct: 1072 LGKKPEIAQVIASYTATGPEQLT-----------LAPGQLI---LIRKKNPGGWWEGELQ 1117
Query: 425 GMGPRPMAG------------STDQIAHLRPQTRPSV-----YVAIYPYTPRKEDELELR 467
G + G T +I P ++ + +Y YT + +DEL
Sbjct: 1118 ARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFN 1177
Query: 468 KGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505
KG++ V + W+KG ++G+FP NYV T
Sbjct: 1178 KGQIINVLNKEDPDWWKGEV--NGQVGLFPSNYVKLTT 1213
Score = 42.4 bits (98), Expect = 0.002
Identities = 23/79 (29%), Positives = 39/79 (49%), Gaps = 3/79 (3%)
Query: 446 RPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSK---IGVFPGNYVA 502
+P + I YT ++L L G++ L+ ++ GW++G K IG FP NYV
Sbjct: 1075 KPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVK 1134
Query: 503 PVTRAVTNASQAKVPMSTA 521
++ + + + P STA
Sbjct: 1135 LLSPGTSKITPTEPPKSTA 1153
Score = 42.0 bits (97), Expect = 0.003
Identities = 19/55 (34%), Positives = 30/55 (54%), Gaps = 3/55 (5%)
Query: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGK---TGLFPGSFVE 886
+V+ SY +L L G ++ + KK GW++G LQ GK G FP ++V+
Sbjct: 1080 QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVK 1134
Score = 41.6 bits (96), Expect = 0.003
Identities = 26/96 (27%), Positives = 47/96 (48%), Gaps = 10/96 (10%)
Query: 417 ATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFE 476
A A A G P P+ G +++ L+ Q A+YP+ +K++ L K ++ V E
Sbjct: 892 AFTPATATGSSPSPVLGQGEKVEGLQAQ-------ALYPWRAKKDNHLNFNKNDVITVLE 944
Query: 477 RCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTNAS 512
+ QD W+ G + G FP +YV ++ + ++
Sbjct: 945 Q-QDMWWFGEVQ--GQKGWFPKSYVKLISGPIRKST 977
Score = 41.6 bits (96), Expect = 0.003
Identities = 32/118 (27%), Positives = 55/118 (46%), Gaps = 14/118 (11%)
Query: 432 AGSTDQIAHLR----PQTRPSV----YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWF 483
+GS++ A L+ P +P V ++A+Y Y ++ +L ++G++ LV ++ D W
Sbjct: 981 SGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWW- 1039
Query: 484 KGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQ 541
T K GVFP NY V + S + G+ +++ TA GP Q
Sbjct: 1040 --TGTVGDKAGVFPSNY---VRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQ 1092
Score = 41.2 bits (95), Expect = 0.004
Identities = 27/90 (30%), Positives = 48/90 (53%), Gaps = 9/90 (10%)
Query: 797 RKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVC-ERHRVVVSYPPQSEAELELKEGDI 855
RK++S+DS +P + +S ++PVV E + +Y + +L ++GD+
Sbjct: 974 RKSTSMDSGSSESPASLKRVASPA-----AKPVVSGEEFIAMYTYESSEQGDLTFQQGDV 1028
Query: 856 VFVHKKREDGWFKGTLQRNGKTGLFPGSFV 885
+ V KK D W+ GT+ K G+FP ++V
Sbjct: 1029 ILVTKKDGD-WWTGTV--GDKAGVFPSNYV 1055
Score = 40.0 bits (92), Expect = 0.010
Identities = 21/67 (31%), Positives = 36/67 (53%), Gaps = 7/67 (10%)
Query: 140 KALYNYEGKEPGDLKFSKGDIIILRRQ-VDEN------WYHGEVNGIHGFFPTNFVQIIK 192
+ALY +E + ++ GDI++++ + VDE+ W GE+ G G+FP N+ + I
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 193 PLPQPPP 199
P P
Sbjct: 806 ENEVPAP 812
Score = 40.0 bits (92), Expect = 0.010
Identities = 23/80 (28%), Positives = 39/80 (48%), Gaps = 14/80 (17%)
Query: 807 PIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGW 866
P PP A +++ V+ + Y Q++ EL +G I+ V K + W
Sbjct: 1145 PTEPPKSTALAAVCQVIG------------MYDYTAQNDDELAFNKGQIINVLNKEDPDW 1192
Query: 867 FKGTLQRNGKTGLFPGSFVE 886
+KG + NG+ GLFP ++V+
Sbjct: 1193 WKGEV--NGQVGLFPSNYVK 1210
Score = 38.5 bits (88), Expect = 0.028
Identities = 31/104 (29%), Positives = 46/104 (44%), Gaps = 21/104 (20%)
Query: 450 YVAIYPYTPRKEDELELRKGEMFLV-------FERCQDGWFKGTSMHTSKIGVFPGNYV- 501
Y A+YP+ R DE+ ++ G++ +V + + GW G K G FP NY
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGEL--KGKTGWFPANYAE 802
Query: 502 --------APVTRAVTNASQAKVPMSTAGQTSR--GVTMVSPST 535
APV + VT+++ A P +T VT PST
Sbjct: 803 KIPENEVPAPV-KPVTDSTSAPAPKLALRETPAPLAVTSSEPST 845
Score = 36.6 bits (83), Expect = 0.11
Identities = 21/62 (33%), Positives = 32/62 (51%), Gaps = 9/62 (14%)
Query: 834 HRVVVSYPPQSEAELELKEGDIVFVH-------KKREDGWFKGTLQRNGKTGLFPGSFVE 886
+R + + +S E+ ++ GDIV V + E GW G L+ GKTG FP ++ E
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELK--GKTGWFPANYAE 802
Query: 887 NI 888
I
Sbjct: 803 KI 804
Score = 31.6 bits (70), Expect = 3.4
Identities = 21/78 (26%), Positives = 39/78 (50%), Gaps = 3/78 (3%)
Query: 811 PPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGT 870
P SS PVL + V + + + + + + L + D++ V +++D W+ G
Sbjct: 895 PATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITV-LEQQDMWWFGE 953
Query: 871 LQRNGKTGLFPGSFVENI 888
+Q G+ G FP S+V+ I
Sbjct: 954 VQ--GQKGWFPKSYVKLI 969
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,291,859
Number of Sequences: 37866
Number of extensions: 2272603
Number of successful extensions: 15203
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 321
Number of HSP's successfully gapped in prelim test: 937
Number of HSP's that attempted gapping in prelim test: 10792
Number of HSP's gapped (non-prelim): 4575
length of query: 888
length of database: 18,247,518
effective HSP length: 111
effective length of query: 777
effective length of database: 14,044,392
effective search space: 10912492584
effective search space used: 10912492584
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.