BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|5174535 melanocortin 5 receptor [Homo sapiens] (325 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|5174535 melanocortin 5 receptor [Homo sapiens] 652 0.0 gi|170671732 melanocortin 3 receptor [Homo sapiens] 393 e-109 gi|119508433 melanocortin 4 receptor [Homo sapiens] 392 e-109 gi|4505127 melanocortin 2 receptor [Homo sapiens] 281 7e-76 gi|193083134 melanocortin 1 receptor [Homo sapiens] 275 4e-74 gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens] 129 5e-30 gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens] 129 5e-30 gi|4885295 G protein-coupled receptor 12 [Homo sapiens] 118 6e-27 gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens] 117 1e-26 gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens] 116 2e-26 gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens] 115 5e-26 gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens] 114 1e-25 gi|4885325 G protein-coupled receptor 3 [Homo sapiens] 113 2e-25 gi|5921992 adenosine A2a receptor [Homo sapiens] 113 3e-25 gi|134244587 endothelial differentiation, sphingolipid G-protein... 106 2e-23 gi|4501951 adenosine A2b receptor [Homo sapiens] 103 2e-22 gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 101 1e-21 gi|13540517 endothelial differentiation, sphingolipid G-protein-... 100 2e-21 gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 100 3e-21 gi|115305569 adenosine A1 receptor [Homo sapiens] 99 4e-21 gi|4501947 adenosine A1 receptor [Homo sapiens] 99 4e-21 gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens] 96 6e-20 gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens] 96 6e-20 gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens] 96 6e-20 gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens] 96 6e-20 gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens] 96 6e-20 gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens] 96 6e-20 gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 94 2e-19 gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 94 2e-19 gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 94 2e-19 >gi|5174535 melanocortin 5 receptor [Homo sapiens] Length = 325 Score = 652 bits (1682), Expect = 0.0 Identities = 325/325 (100%), Positives = 325/325 (100%) Query: 1 MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA 60 MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA Sbjct: 1 MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA 60 Query: 61 IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS 120 IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS Sbjct: 61 IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS 120 Query: 121 MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY 180 MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY Sbjct: 121 MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY 180 Query: 181 SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV 240 SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV Sbjct: 181 SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV 240 Query: 241 TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ 300 TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ Sbjct: 241 TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ 300 Query: 301 EMRKTFKEIICCRGFRIACSFPRRD 325 EMRKTFKEIICCRGFRIACSFPRRD Sbjct: 301 EMRKTFKEIICCRGFRIACSFPRRD 325 >gi|170671732 melanocortin 3 receptor [Homo sapiens] Length = 323 Score = 393 bits (1009), Expect = e-109 Identities = 197/322 (61%), Positives = 250/322 (77%), Gaps = 5/322 (1%) Query: 1 MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSP--CEDMGIAVEVFLTLGVISLLENILVI 58 MN+S L + L +L P N+SS CE + I EVFL+LG++SLLENILVI Sbjct: 1 MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVI 60 Query: 59 GAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVF 118 A+V+N NLHSPMYFF+CSLAVADMLVS+S+A ETI I ++++ +L D F++H+DN+F Sbjct: 61 LAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIF 120 Query: 119 DSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFI 178 DSMICIS+VAS+C+LLAIAVDRYVTIFYALRYH IMT R++ +I IW C CG+VFI Sbjct: 121 DSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFI 180 Query: 179 LYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGAS--SARQRTSMQG 236 +YSES VI+CLI+MFFAM+ L+ +LY+HMFL AR HVKRIAALP A + +Q + M+G Sbjct: 181 VYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKG 240 Query: 237 AVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYA 296 AVT+T+LLGVF CWAPFFLHL L+++CP N YC + +HFN YL+LIMCNSV+DPLIYA Sbjct: 241 AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA 300 Query: 297 FRSQEMRKTFKEIIC-CRGFRI 317 FRS E+R TF+EI+C C G + Sbjct: 301 FRSLELRNTFREILCGCNGMNL 322 >gi|119508433 melanocortin 4 receptor [Homo sapiens] Length = 332 Score = 392 bits (1008), Expect = e-109 Identities = 194/291 (66%), Positives = 235/291 (80%), Gaps = 1/291 (0%) Query: 34 EDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWET 93 E + ++ EVF+TLGVISLLENILVI AI KNKNLHSPMYFF+CSLAVADMLVS+S+ ET Sbjct: 42 EQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSET 101 Query: 94 ITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHI 153 I I LLN+ A +F +IDNV DS+IC S++AS+CSLL+IAVDRY TIFYAL+YH+I Sbjct: 102 IVITLLNSTD-TDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNI 160 Query: 154 MTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLAR 213 MT +R G II+ IWA CT GI+FI+YS+S+ VI+CLI+MFF ML L+ SLY+HMFL+AR Sbjct: 161 MTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMAR 220 Query: 214 THVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRF 273 H+KRIA LPG + RQ +M+GA+T+T+L+GVF VCWAPFFLHL +SCPQN YC F Sbjct: 221 LHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCF 280 Query: 274 MSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRR 324 MSHFN+YLILIMCNS++DPLIYA RSQE+RKTFKEIICC C R Sbjct: 281 MSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSR 331 >gi|4505127 melanocortin 2 receptor [Homo sapiens] Length = 297 Score = 281 bits (718), Expect = 7e-76 Identities = 134/288 (46%), Positives = 194/288 (67%), Gaps = 7/288 (2%) Query: 25 NVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADML 84 N +S C + + E+F T+ ++ +LEN++V+ A+ KNKNL +PMYFF+CSLA++DML Sbjct: 13 NTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDML 72 Query: 85 VSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTI 144 S+ E I I L N +L +F D++ DS+ +S++ S+ SL IA DRY+TI Sbjct: 73 GSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITI 132 Query: 145 FYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSL 204 F+ALRYH I+T RR+ ++ IW FCTG GI +++S ++ S+F ML ++ L Sbjct: 133 FHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPLMLVFILCL 192 Query: 205 YIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSC 264 Y+HMFLLAR+H ++I+ LP R +M+GA+T+T+LLGVF CWAPF LH+ LM C Sbjct: 193 YVHMFLLARSHTRKISTLP-------RANMKGAITLTILLGVFIFCWAPFVLHVLLMTFC 245 Query: 265 PQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICC 312 P N YC+ +MS F + +LIMCN+V+DP IYAFRS E+R FK++I C Sbjct: 246 PSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFC 293 >gi|193083134 melanocortin 1 receptor [Homo sapiens] Length = 317 Score = 275 bits (703), Expect = 4e-74 Identities = 135/281 (48%), Positives = 191/281 (67%), Gaps = 1/281 (0%) Query: 33 CEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWE 92 C ++ I+ +FL+LG++SL+EN LV+ I KN+NLHSPMY F+C LA++D+LVS S+ E Sbjct: 35 CLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLE 94 Query: 93 TITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHH 152 T I LL LV A ++ +DNV D + C S+++S+C L AIAVDRY++IFYALRYH Sbjct: 95 TAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHS 154 Query: 153 IMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLA 212 I+T R+ +A IW +FI Y + V+LCL+ F AML L+ LY+HM A Sbjct: 155 IVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARA 214 Query: 213 RTHVKRIAAL-PGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCS 271 H + IA L Q ++GAVT+T+LLG+F +CW PFFLHLTL++ CP++ C Sbjct: 215 CQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCG 274 Query: 272 RFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICC 312 +FN++L LI+CN+++DPLIYAF SQE+R+T KE++ C Sbjct: 275 CIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTC 315 >gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens] Length = 364 Score = 129 bits (323), Expect = 5e-30 Identities = 84/292 (28%), Positives = 145/292 (49%), Gaps = 41/292 (14%) Query: 44 LTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLL---- 99 +T+ + +L N+LV+ AI N+ H P+Y+ + +LA AD ++ YL+ Sbjct: 57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAY------FYLMFNTG 110 Query: 100 -NNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARR 158 N + L ++ +R +I S+ AS+ +LLAIA++R++T+F ++ H M+ RR Sbjct: 111 PNTRRLTVSTWLLRQ------GLIDTSLTASVANLLAIAIERHITVF-RMQLHTRMSNRR 163 Query: 159 SGAIIAGIWAFCT-----------------GCGIVFILYSESTYVILCLISMFFAMLFLL 201 +I IW C + LYS+S V + ++ ++ Sbjct: 164 VVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNL--VTFVVM 221 Query: 202 VSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLM 261 V LY H+F R R++ + T M TV ++LG F +CW P + L L Sbjct: 222 VVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLD 281 Query: 262 LSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCR 313 + CPQ C +++ +L+L NS M+P+IY++R +EM TF++I+CC+ Sbjct: 282 VCCPQ---CD-VLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQ 329 >gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens] Length = 364 Score = 129 bits (323), Expect = 5e-30 Identities = 84/292 (28%), Positives = 145/292 (49%), Gaps = 41/292 (14%) Query: 44 LTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLL---- 99 +T+ + +L N+LV+ AI N+ H P+Y+ + +LA AD ++ YL+ Sbjct: 57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAY------FYLMFNTG 110 Query: 100 -NNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARR 158 N + L ++ +R +I S+ AS+ +LLAIA++R++T+F ++ H M+ RR Sbjct: 111 PNTRRLTVSTWLLRQ------GLIDTSLTASVANLLAIAIERHITVF-RMQLHTRMSNRR 163 Query: 159 SGAIIAGIWAFCT-----------------GCGIVFILYSESTYVILCLISMFFAMLFLL 201 +I IW C + LYS+S V + ++ ++ Sbjct: 164 VVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNL--VTFVVM 221 Query: 202 VSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLM 261 V LY H+F R R++ + T M TV ++LG F +CW P + L L Sbjct: 222 VVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLD 281 Query: 262 LSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCR 313 + CPQ C +++ +L+L NS M+P+IY++R +EM TF++I+CC+ Sbjct: 282 VCCPQ---CD-VLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQ 329 >gi|4885295 G protein-coupled receptor 12 [Homo sapiens] Length = 334 Score = 118 bits (296), Expect = 6e-27 Identities = 84/286 (29%), Positives = 143/286 (50%), Gaps = 33/286 (11%) Query: 42 VFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNN 101 V T G + EN +V+ I N +L +PM+ + SLA+AD+L + + YLL + Sbjct: 50 VLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQS 109 Query: 102 KHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGA 161 + + V +I S AS+CSLLAI VDRY++++YAL YH T + Sbjct: 110 EATKL----------VTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYV 159 Query: 162 IIAGIWAFCTGCGIVFI-----LYSESTYVIL--------CLISMFFAMLF-LLVSLYIH 207 ++ +W G++ + L EST ++ ++S+ F +F L++ LYI Sbjct: 160 MLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQ 219 Query: 208 MFLLARTHVKRIAALPG-ASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQ 266 + + H +IA +++ T+ +G T+ ++LG F CW PF L+ + Sbjct: 220 ICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYP 279 Query: 267 NLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICC 312 ++Y L+ NS+++P+IYAFR+QE++K +ICC Sbjct: 280 SIYT-------YATLLPATYNSIINPVIYAFRNQEIQKALC-LICC 317 >gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens] Length = 382 Score = 117 bits (294), Expect = 1e-26 Identities = 84/290 (28%), Positives = 143/290 (49%), Gaps = 31/290 (10%) Query: 42 VFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNN 101 VF+ + +LENI V+ I K K H PMY+F+ +LA++D+L ++ + Sbjct: 51 VFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTY 110 Query: 102 KHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGA 161 K L A F+R + + +++ AS+ SLLAIA++RY+T+ ++ H+ R Sbjct: 111 K-LTPAQWFLR------EGSMFVALSASVFSLLAIAIERYITML-KMKLHNGSNNFRLFL 162 Query: 162 IIAGIWAF-----------------CTGCGIVFILYSESTYVILCLISMFFAMLFLLVSL 204 +I+ W + C V LY + Y++ C ++F +L +V L Sbjct: 163 LISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKH-YILFC-TTVFTLLLLSIVIL 220 Query: 205 YIHMFLLARTHVKRIAALPGASSARQRTSMQGAV--TVTMLLGVFTVCWAPFFLHLTLML 262 Y ++ L RT +R+ S A + + A+ TV ++L VF CWAP F+ L L + Sbjct: 221 YCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDV 280 Query: 263 SCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICC 312 C F + + +L+L + NS +P+IY ++EMR+ F I+ C Sbjct: 281 GCKVKTCDILFRAEY--FLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSC 328 >gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens] Length = 353 Score = 116 bits (291), Expect = 2e-26 Identities = 90/316 (28%), Positives = 157/316 (49%), Gaps = 48/316 (15%) Query: 25 NVKNKSSPCEDMGIAVEVFLTLGVISLL----ENILVIGAIVKNKNLHSPMYFFVCSLAV 80 N N + + G + + L +G L N LVI A++KN+ H P Y+ + +LA Sbjct: 15 NRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAA 74 Query: 81 ADMLVSMSSAWETITIYLLNN-----KHLVIADAFVRHIDNVFDSMICISVVASMCSLLA 135 AD ++ ++L+ N K L + F+R + DS S+ AS+ +LL Sbjct: 75 ADFFAGIAY------VFLMFNTGPVSKTLTVNRWFLRQ--GLLDS----SLTASLTNLLV 122 Query: 136 IAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFC-----------------TGCGIVFI 178 IAV+R+++I +R H +T +R +I +WA + C + Sbjct: 123 IAVERHMSIM-RMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAP 181 Query: 179 LYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAV 238 +YS S Y++ +S A L ++V +Y+ +++ + ++ S +R+RT M+ Sbjct: 182 IYSRS-YLVFWTVSNLMAFLIMVV-VYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMK 239 Query: 239 TVTMLLGVFTVCWAPFFLHLTLM-LSCPQNLYCSRFMSHFNM-YLILIMCNSVMDPLIYA 296 TV +LG F VCW P + L L L+C Q C + H +L+L + NSV++P+IY+ Sbjct: 240 TVMTVLGAFVVCWTPGLVVLLLDGLNCRQ---CG--VQHVKRWFLLLALLNSVVNPIIYS 294 Query: 297 FRSQEMRKTFKEIICC 312 ++ ++M T K++ICC Sbjct: 295 YKDEDMYGTMKKMICC 310 >gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens] Length = 378 Score = 115 bits (288), Expect = 5e-26 Identities = 82/297 (27%), Positives = 148/297 (49%), Gaps = 38/297 (12%) Query: 34 EDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWET 93 E + +FL + +LEN++V+ AI KN H+ MYFF+ +LA+ D+L ++ Sbjct: 37 EGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIA---YK 93 Query: 94 ITIYLLNNKHLVIADA--FVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYH 151 + I + K ++ F+R + + +++ AS CSLLAIA++R++T+ +R + Sbjct: 94 VNILMSGKKTFSLSPTVWFLR------EGSMFVALGASTCSLLAIAIERHLTMI-KMRPY 146 Query: 152 HIMTARRSGAIIAGIW--AFCTG---------------CGIVFILYSESTYVILCLISMF 194 R +I W AF G C + LYS+ Y+ C IS+F Sbjct: 147 DANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKK-YIAFC-ISIF 204 Query: 195 FAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPF 254 A+L +V LY ++ L ++ +++ A+ SM TV +++ VF CW+P Sbjct: 205 TAILVTIVILYARIYFLVKSSSRKV-----ANHNNSERSMALLRTVVIVVSVFIACWSPL 259 Query: 255 FLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIIC 311 F+ + ++C + + +++L + NS M+P+IY S+EMR+ F ++C Sbjct: 260 FILFLIDVAC--RVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVC 314 >gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens] Length = 351 Score = 114 bits (285), Expect = 1e-25 Identities = 83/302 (27%), Positives = 145/302 (48%), Gaps = 42/302 (13%) Query: 38 IAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIY 97 + V + LT+ V+ LL N+LVI AI N+ H P+Y+ + +LA AD+ ++ ++ Sbjct: 34 VVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVA------YLF 87 Query: 98 LL-----NNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHH 152 L+ L + F+R ++ S+ AS+ +LLAIAV+R+ ++ A++ H Sbjct: 88 LMFHTGPRTARLSLEGWFLR------QGLLDTSLTASVATLLAIAVERHRSVM-AVQLHS 140 Query: 153 IMTARRSGAIIAGIWAFCTGCGI-----------------VFILYSESTYVILCLISMFF 195 + R +I G+W G G+ + L S S + L S+ Sbjct: 141 RLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLL- 199 Query: 196 AMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFF 255 + L+V++Y +F R V+R+A + T++ TV ++LG F VCW P Sbjct: 200 -VFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQ 258 Query: 256 LHLTL-MLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRG 314 + L L L C ++ +L+L NS+++ +Y+ R EMR+TF+ ++CC Sbjct: 259 VVLLLDGLGCES----CNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCAC 314 Query: 315 FR 316 R Sbjct: 315 LR 316 >gi|4885325 G protein-coupled receptor 3 [Homo sapiens] Length = 330 Score = 113 bits (283), Expect = 2e-25 Identities = 79/286 (27%), Positives = 136/286 (47%), Gaps = 42/286 (14%) Query: 47 GVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVI 106 G + EN LV+ IV +PM+ V SLAVAD+L + ++ + + + + Sbjct: 51 GTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCIGSAEMSL 110 Query: 107 ADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGI 166 V ++ ++ AS+ SLLAI VDRY++++ AL Y+ T R+ ++A + Sbjct: 111 ----------VLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALV 160 Query: 167 WAFCTGCGIVFIL--------------YSESTYVILCLISMFFAMLFLLVSLYIHMFLLA 212 W G G++ +L Y S ++ L FF + +++ LY + + Sbjct: 161 WGGALGLGLLPVLAWNCLDGLTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIV 220 Query: 213 RTHVKRIA----ALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNL 268 H ++IA LP + R +G T+ ++LG F CW PF ++ L + L Sbjct: 221 CRHAQQIALQRHLLPASHYVATR---KGIATLAVVLGAFAACWLPFTVYCLLGDAHSPPL 277 Query: 269 YCSRFMSHFNMYLILIMC--NSVMDPLIYAFRSQEMRKTFKEIICC 312 Y YL L+ NS+++P+IYAFR+Q+++K + CC Sbjct: 278 Y---------TYLTLLPATYNSMINPIIYAFRNQDVQKVLWAVCCC 314 >gi|5921992 adenosine A2a receptor [Homo sapiens] Length = 412 Score = 113 bits (282), Expect = 3e-25 Identities = 89/315 (28%), Positives = 149/315 (47%), Gaps = 49/315 (15%) Query: 32 PCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAW 91 P + + V L + V+++L N+LV A+ N NL + +FV SLA AD+ V + + Sbjct: 2 PIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP 61 Query: 92 ETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYH 151 ITI H + + +S+ SLLAIA+DRY+ I LRY+ Sbjct: 62 FAITIST--------GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYN 113 Query: 152 HIMTARRSGAIIAGIWAFC------------------------TGCGI--VFILYSESTY 185 ++T R+ IIA W GCG V L+ + Sbjct: 114 GLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVP 173 Query: 186 VILCLISMFFAM----LFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQ----GA 237 + + FFA L L++ +Y+ +FL AR +K++ + P R R+++Q A Sbjct: 174 MNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQP-LPGERARSTLQKEVHAA 232 Query: 238 VTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMC--NSVMDPLIY 295 ++ +++G+F +CW P + CP + ++ MYL +++ NSV++P IY Sbjct: 233 KSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWL----MYLAIVLSHTNSVVNPFIY 288 Query: 296 AFRSQEMRKTFKEII 310 A+R +E R+TF++II Sbjct: 289 AYRIREFRQTFRKII 303 >gi|134244587 endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 [Homo sapiens] Length = 353 Score = 106 bits (265), Expect = 2e-23 Identities = 84/326 (25%), Positives = 156/326 (47%), Gaps = 40/326 (12%) Query: 4 SFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVK 63 S + +L+ N N + ++ + + + A V L ++ +EN+LV+ A+ + Sbjct: 3 SLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIV--VENLLVLIAVAR 60 Query: 64 NKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMIC 123 N HS MY F+ +LA +D+L ++ T+ + + L F R + Sbjct: 61 NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLR-LTPVQWFAR------EGSAF 113 Query: 124 ISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAF-------------C 170 I++ AS+ SLLAIA++R+V I Y + R +I W C Sbjct: 114 ITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRML-LLIGASWLISLVLGGLPILGWNC 172 Query: 171 TG----CGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGAS 226 G C V LY++ + +LC++++F +L +V+LY+ ++ + R+ +AA + Sbjct: 173 LGHLEACSTVLPLYAK--HYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLA 230 Query: 227 SARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMC 286 + TVT++LGVF VCW P F L L +CP + + +H+ + + Sbjct: 231 LLK---------TVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHY--FFAVSTL 279 Query: 287 NSVMDPLIYAFRSQEMRKTFKEIICC 312 NS+++P+IY +RS+++R+ + C Sbjct: 280 NSLLNPVIYTWRSRDLRREVLRPLQC 305 >gi|4501951 adenosine A2b receptor [Homo sapiens] Length = 332 Score = 103 bits (257), Expect = 2e-22 Identities = 81/305 (26%), Positives = 141/305 (46%), Gaps = 44/305 (14%) Query: 40 VEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLL 99 V + L + +S+ N+LV A+ L +P +F+ SLA AD+ V + + ITI Sbjct: 11 VALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITI--- 67 Query: 100 NNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRS 159 L F + + + +S+ SLLA+AVDRY+ I LRY ++T R+ Sbjct: 68 ---SLGFCTDFYGCL--FLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRA 122 Query: 160 GAIIAGIWAFCTGCGIVFIL-------------------YSESTYVILCLISMFFAM--- 197 +IA +W G G+ L +ES ++ CL M Sbjct: 123 RGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYM 182 Query: 198 ------------LFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLG 245 L +++ +YI +FL+A ++R + + + QR + A ++ M++G Sbjct: 183 VYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQR-EIHAAKSLAMIVG 241 Query: 246 VFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKT 305 +F +CW P + L P ++ NM ++L NSV++P++YA+R+++ R T Sbjct: 242 IFALCWLPVHAVNCVTLFQPAQ-GKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT 300 Query: 306 FKEII 310 F +II Sbjct: 301 FHKII 305 >gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] Length = 572 Score = 101 bits (251), Expect = 1e-21 Identities = 87/338 (25%), Positives = 152/338 (44%), Gaps = 74/338 (21%) Query: 37 GIAVEVFLTLGVI-SLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETIT 95 G+ V VFL ++ ++ N+LVI ++ N++L + +F+ +LAVAD+L+S + + T Sbjct: 96 GVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSAT 155 Query: 96 IYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMT 155 + +L AF R +V+ ++ + AS+ SL I+VDRYV + ++L+Y IMT Sbjct: 156 MEVLGFW------AFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMT 209 Query: 156 ARRSGAIIAGIWAFC-------------------TGCGIVFILYSESTYVILCLISMFFA 196 R++ AI+A +W CGI E+ Y + + F+ Sbjct: 210 ERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGIT----EEAGYAVFSSVCSFYL 265 Query: 197 MLFLLVSLYIHMFLLARTHVKRI---------------------AALPGASSARQRTSMQ 235 + ++V +Y ++++AR+ + + A GA A S + Sbjct: 266 PMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAK 325 Query: 236 G--------------------AVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMS 275 G A T+ +++GVF +CW PFF L L PQ Sbjct: 326 GHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQ---LKPSEG 382 Query: 276 HFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCR 313 F + L NS ++PLIY S+E ++ F ++ C+ Sbjct: 383 VFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ 420 >gi|13540517 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 [Homo sapiens] Length = 398 Score = 100 bits (248), Expect = 2e-21 Identities = 81/302 (26%), Positives = 151/302 (50%), Gaps = 39/302 (12%) Query: 37 GIAVEVFLTLGVIS--LLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETI 94 G+ + + L V + +LEN+ V+ + ++ H+PM+ + SL ++D+L + A + Sbjct: 35 GLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANIL 94 Query: 95 TIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIM 154 L K L A F R + + +++ AS+ SLLAIA++R +T+ A R + Sbjct: 95 LSGPLTLK-LSPALWFAR------EGGVFVALTASVLSLLAIALERSLTM--ARRGPAPV 145 Query: 155 TAR-RSGAIIAGIWAF-------------CTG----CGIVFILYSESTYVILCLISMFFA 196 ++R R+ A+ A W C G C V LY+++ YV+ C+++ F Sbjct: 146 SSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKA-YVLFCVLA-FVG 203 Query: 197 MLFLLVSLYIHMFLLARTHVKRIAALPGASSA------RQRTSMQGAVTVTMLLGVFTVC 250 +L + +LY ++ R + +R+ A PG + R+ S+ T++++L F C Sbjct: 204 ILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVAC 263 Query: 251 WAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEII 310 W P FL L L ++CP + + +L L M NS+++P+IY ++++R ++ Sbjct: 264 WGPLFLLLLLDVACPART--CPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLV 321 Query: 311 CC 312 CC Sbjct: 322 CC 323 >gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] Length = 520 Score = 99.8 bits (247), Expect = 3e-21 Identities = 89/380 (23%), Positives = 171/380 (45%), Gaps = 91/380 (23%) Query: 2 NSSFHLHFLDLNLNATEGNLSGPNVKNKSS--PCEDMGIAVEVFLTLG---VISLLENIL 56 N+S H+ +L N +GPN + +S P D+ A+ V L LG + +++ NIL Sbjct: 10 NTSAPAHWGELK----NANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNIL 65 Query: 57 VIGAIVKNKNLHSPMYFFVCSLAVADMLVSM-----SSAWETITIYLLNNKHLVIADAFV 111 VI ++ N++L +P +F+ +LA+AD+L+S S+A E + ++L + D + Sbjct: 66 VILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGR---IFCDIWA 122 Query: 112 RHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCT 171 D + C + + S+C AI++DRY+ + Y+L+Y ++T R++ + +W T Sbjct: 123 -----AVDVLCCTASILSLC---AISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLST 174 Query: 172 GCGIVFIL---------------YSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHV 216 I +L E Y + + F+ L +++ +Y ++++A+ Sbjct: 175 VISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTT 234 Query: 217 KRIAA--LPGASSARQRT------------------------------------SMQGAV 238 K + A + S++++ T + A Sbjct: 235 KNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAK 294 Query: 239 TVTMLLGVFTVCWAPFFLHLTL-----MLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPL 293 T+ +++G+F +CW PFF+ L L L P + F + L NS ++P+ Sbjct: 295 TLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAV--------FKVVFWLGYFNSCLNPI 346 Query: 294 IYAFRSQEMRKTFKEIICCR 313 IY S+E ++ F I+ C+ Sbjct: 347 IYPCSSKEFKRAFVRILGCQ 366 >gi|115305569 adenosine A1 receptor [Homo sapiens] Length = 326 Score = 99.4 bits (246), Expect = 4e-21 Identities = 89/303 (29%), Positives = 143/303 (47%), Gaps = 44/303 (14%) Query: 38 IAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIY 97 I +EV + L +S+ N+LVI A+ N+ L + F+ SLAVAD+ V I + Sbjct: 13 IGIEVLIAL--VSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGAL----VIPLA 66 Query: 98 LLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTAR 157 +L N I H + + I +S+ +LLAIAVDRY+ + LRY ++T R Sbjct: 67 ILIN----IGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPR 122 Query: 158 RSGAIIAGIW--AFCTGCGIVFILYSESTY-------------VILC----LISMFFAML 198 R+ IAG W +F G +F + S VI C +ISM + + Sbjct: 123 RAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVY 182 Query: 199 F-----------LLVSLYIHMFLLARTHV-KRIAALPGASSARQRTSMQGAVTVTMLLGV 246 F L+V +Y+ +F L R + K+++A G ++ A ++ ++L + Sbjct: 183 FNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFL 242 Query: 247 FTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTF 306 F + W P + + L CP C + + + L NS M+P++YAFR Q+ R TF Sbjct: 243 FALSWLPLHILNCITLFCPS---CHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTF 299 Query: 307 KEI 309 +I Sbjct: 300 LKI 302 >gi|4501947 adenosine A1 receptor [Homo sapiens] Length = 326 Score = 99.4 bits (246), Expect = 4e-21 Identities = 89/303 (29%), Positives = 143/303 (47%), Gaps = 44/303 (14%) Query: 38 IAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIY 97 I +EV + L +S+ N+LVI A+ N+ L + F+ SLAVAD+ V I + Sbjct: 13 IGIEVLIAL--VSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGAL----VIPLA 66 Query: 98 LLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTAR 157 +L N I H + + I +S+ +LLAIAVDRY+ + LRY ++T R Sbjct: 67 ILIN----IGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPR 122 Query: 158 RSGAIIAGIW--AFCTGCGIVFILYSESTY-------------VILC----LISMFFAML 198 R+ IAG W +F G +F + S VI C +ISM + + Sbjct: 123 RAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVY 182 Query: 199 F-----------LLVSLYIHMFLLARTHV-KRIAALPGASSARQRTSMQGAVTVTMLLGV 246 F L+V +Y+ +F L R + K+++A G ++ A ++ ++L + Sbjct: 183 FNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFL 242 Query: 247 FTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTF 306 F + W P + + L CP C + + + L NS M+P++YAFR Q+ R TF Sbjct: 243 FALSWLPLHILNCITLFCPS---CHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTF 299 Query: 307 KEI 309 +I Sbjct: 300 LKI 302 >gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 95.5 bits (236), Expect = 6e-20 Identities = 82/318 (25%), Positives = 143/318 (44%), Gaps = 46/318 (14%) Query: 31 SPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHS-PMYFFVCSLAVADMLVSMSS 89 +P + + IAV + LTLG ++LEN+LV+ I+ +++L P Y F+ SLAVAD+L S+ Sbjct: 112 NPSQQLAIAV-LSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIF 170 Query: 90 AWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALR 149 + I ++ + K + F+ + V S AS+ SL A+DRY++I L Sbjct: 171 VYSFIDFHVFHRKDS--RNVFLFKLGGV-----TASFTASVGSLFLTAIDRYISIHRPLA 223 Query: 150 YHHIMTARRSGAIIAGIWAFCTGCGIVFIL----------------YSESTYVILCLISM 193 Y I+T ++ +W ++ +L + + TY ++ I + Sbjct: 224 YKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETY-LMFWIGV 282 Query: 194 FFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVT------------ 241 +L +V Y+++ A +H R+ S TS G V VT Sbjct: 283 TSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLA 342 Query: 242 ----MLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAF 297 ++L V +CW P + + N + +M L + NS ++P+IYA Sbjct: 343 KTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSM---LCLLNSTVNPIIYAL 399 Query: 298 RSQEMRKTFKEII-CCRG 314 RS+++R F+ + C G Sbjct: 400 RSKDLRHAFRSMFPSCEG 417 >gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 95.5 bits (236), Expect = 6e-20 Identities = 82/318 (25%), Positives = 143/318 (44%), Gaps = 46/318 (14%) Query: 31 SPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHS-PMYFFVCSLAVADMLVSMSS 89 +P + + IAV + LTLG ++LEN+LV+ I+ +++L P Y F+ SLAVAD+L S+ Sbjct: 112 NPSQQLAIAV-LSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIF 170 Query: 90 AWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALR 149 + I ++ + K + F+ + V S AS+ SL A+DRY++I L Sbjct: 171 VYSFIDFHVFHRKDS--RNVFLFKLGGV-----TASFTASVGSLFLTAIDRYISIHRPLA 223 Query: 150 YHHIMTARRSGAIIAGIWAFCTGCGIVFIL----------------YSESTYVILCLISM 193 Y I+T ++ +W ++ +L + + TY ++ I + Sbjct: 224 YKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETY-LMFWIGV 282 Query: 194 FFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVT------------ 241 +L +V Y+++ A +H R+ S TS G V VT Sbjct: 283 TSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLA 342 Query: 242 ----MLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAF 297 ++L V +CW P + + N + +M L + NS ++P+IYA Sbjct: 343 KTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSM---LCLLNSTVNPIIYAL 399 Query: 298 RSQEMRKTFKEII-CCRG 314 RS+++R F+ + C G Sbjct: 400 RSKDLRHAFRSMFPSCEG 417 >gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 95.5 bits (236), Expect = 6e-20 Identities = 82/318 (25%), Positives = 143/318 (44%), Gaps = 46/318 (14%) Query: 31 SPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHS-PMYFFVCSLAVADMLVSMSS 89 +P + + IAV + LTLG ++LEN+LV+ I+ +++L P Y F+ SLAVAD+L S+ Sbjct: 112 NPSQQLAIAV-LSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIF 170 Query: 90 AWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALR 149 + I ++ + K + F+ + V S AS+ SL A+DRY++I L Sbjct: 171 VYSFIDFHVFHRKDS--RNVFLFKLGGV-----TASFTASVGSLFLTAIDRYISIHRPLA 223 Query: 150 YHHIMTARRSGAIIAGIWAFCTGCGIVFIL----------------YSESTYVILCLISM 193 Y I+T ++ +W ++ +L + + TY ++ I + Sbjct: 224 YKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETY-LMFWIGV 282 Query: 194 FFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVT------------ 241 +L +V Y+++ A +H R+ S TS G V VT Sbjct: 283 TSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLA 342 Query: 242 ----MLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAF 297 ++L V +CW P + + N + +M L + NS ++P+IYA Sbjct: 343 KTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSM---LCLLNSTVNPIIYAL 399 Query: 298 RSQEMRKTFKEII-CCRG 314 RS+++R F+ + C G Sbjct: 400 RSKDLRHAFRSMFPSCEG 417 >gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 95.5 bits (236), Expect = 6e-20 Identities = 82/318 (25%), Positives = 143/318 (44%), Gaps = 46/318 (14%) Query: 31 SPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHS-PMYFFVCSLAVADMLVSMSS 89 +P + + IAV + LTLG ++LEN+LV+ I+ +++L P Y F+ SLAVAD+L S+ Sbjct: 112 NPSQQLAIAV-LSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIF 170 Query: 90 AWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALR 149 + I ++ + K + F+ + V S AS+ SL A+DRY++I L Sbjct: 171 VYSFIDFHVFHRKDS--RNVFLFKLGGV-----TASFTASVGSLFLTAIDRYISIHRPLA 223 Query: 150 YHHIMTARRSGAIIAGIWAFCTGCGIVFIL----------------YSESTYVILCLISM 193 Y I+T ++ +W ++ +L + + TY ++ I + Sbjct: 224 YKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETY-LMFWIGV 282 Query: 194 FFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVT------------ 241 +L +V Y+++ A +H R+ S TS G V VT Sbjct: 283 TSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLA 342 Query: 242 ----MLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAF 297 ++L V +CW P + + N + +M L + NS ++P+IYA Sbjct: 343 KTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSM---LCLLNSTVNPIIYAL 399 Query: 298 RSQEMRKTFKEII-CCRG 314 RS+++R F+ + C G Sbjct: 400 RSKDLRHAFRSMFPSCEG 417 >gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 95.5 bits (236), Expect = 6e-20 Identities = 82/318 (25%), Positives = 143/318 (44%), Gaps = 46/318 (14%) Query: 31 SPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHS-PMYFFVCSLAVADMLVSMSS 89 +P + + IAV + LTLG ++LEN+LV+ I+ +++L P Y F+ SLAVAD+L S+ Sbjct: 112 NPSQQLAIAV-LSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIF 170 Query: 90 AWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALR 149 + I ++ + K + F+ + V S AS+ SL A+DRY++I L Sbjct: 171 VYSFIDFHVFHRKDS--RNVFLFKLGGV-----TASFTASVGSLFLTAIDRYISIHRPLA 223 Query: 150 YHHIMTARRSGAIIAGIWAFCTGCGIVFIL----------------YSESTYVILCLISM 193 Y I+T ++ +W ++ +L + + TY ++ I + Sbjct: 224 YKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETY-LMFWIGV 282 Query: 194 FFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVT------------ 241 +L +V Y+++ A +H R+ S TS G V VT Sbjct: 283 TSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLA 342 Query: 242 ----MLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAF 297 ++L V +CW P + + N + +M L + NS ++P+IYA Sbjct: 343 KTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSM---LCLLNSTVNPIIYAL 399 Query: 298 RSQEMRKTFKEII-CCRG 314 RS+++R F+ + C G Sbjct: 400 RSKDLRHAFRSMFPSCEG 417 >gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens] Length = 439 Score = 95.5 bits (236), Expect = 6e-20 Identities = 82/318 (25%), Positives = 143/318 (44%), Gaps = 46/318 (14%) Query: 31 SPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHS-PMYFFVCSLAVADMLVSMSS 89 +P + + IAV + LTLG ++LEN+LV+ I+ +++L P Y F+ SLAVAD+L S+ Sbjct: 79 NPSQQLAIAV-LSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIF 137 Query: 90 AWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALR 149 + I ++ + K + F+ + V S AS+ SL A+DRY++I L Sbjct: 138 VYSFIDFHVFHRKDS--RNVFLFKLGGV-----TASFTASVGSLFLTAIDRYISIHRPLA 190 Query: 150 YHHIMTARRSGAIIAGIWAFCTGCGIVFIL----------------YSESTYVILCLISM 193 Y I+T ++ +W ++ +L + + TY ++ I + Sbjct: 191 YKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETY-LMFWIGV 249 Query: 194 FFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVT------------ 241 +L +V Y+++ A +H R+ S TS G V VT Sbjct: 250 TSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLA 309 Query: 242 ----MLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAF 297 ++L V +CW P + + N + +M L + NS ++P+IYA Sbjct: 310 KTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSM---LCLLNSTVNPIIYAL 366 Query: 298 RSQEMRKTFKEII-CCRG 314 RS+++R F+ + C G Sbjct: 367 RSKDLRHAFRSMFPSCEG 384 >gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] Length = 455 Score = 93.6 bits (231), Expect = 2e-19 Identities = 88/364 (24%), Positives = 160/364 (43%), Gaps = 78/364 (21%) Query: 12 LNLNATEG-NLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSP 70 L+ NA++ N + P S +G+ + + GV+ NILVI ++ +++LHS Sbjct: 4 LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLG---NILVILSVACHRHLHSV 60 Query: 71 MYFFVCSLAVADMLVS-----MSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICIS 125 ++++ +LAVAD+L++ S+ +E + + AF R N++ ++ + Sbjct: 61 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYW-----------AFGRVFCNIWAAVDVLC 109 Query: 126 VVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGI---------- 175 AS+ L I++DRY+ + Y LRY I+T RR + +WA I Sbjct: 110 CTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPA 169 Query: 176 -----VFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLA------------------ 212 + + E YV+ + F+ L +++ +Y ++++A Sbjct: 170 PEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDS 229 Query: 213 -----RTHVKRI-AALPGASSARQRT-----------SMQGAVTVTMLLGVFTVCWAPFF 255 R H K A G +SA+ +T + A T+ +++G F +CW PFF Sbjct: 230 EQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFF 289 Query: 256 LHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGF 315 L + + P + F + L NS ++P+IY SQE +K F+ ++ Sbjct: 290 LVMPIGSFFPD---FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL----- 341 Query: 316 RIAC 319 RI C Sbjct: 342 RIQC 345 >gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] Length = 466 Score = 93.6 bits (231), Expect = 2e-19 Identities = 88/364 (24%), Positives = 160/364 (43%), Gaps = 78/364 (21%) Query: 12 LNLNATEG-NLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSP 70 L+ NA++ N + P S +G+ + + GV+ NILVI ++ +++LHS Sbjct: 4 LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLG---NILVILSVACHRHLHSV 60 Query: 71 MYFFVCSLAVADMLVS-----MSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICIS 125 ++++ +LAVAD+L++ S+ +E + + AF R N++ ++ + Sbjct: 61 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYW-----------AFGRVFCNIWAAVDVLC 109 Query: 126 VVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGI---------- 175 AS+ L I++DRY+ + Y LRY I+T RR + +WA I Sbjct: 110 CTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPA 169 Query: 176 -----VFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLA------------------ 212 + + E YV+ + F+ L +++ +Y ++++A Sbjct: 170 PEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDS 229 Query: 213 -----RTHVKRI-AALPGASSARQRT-----------SMQGAVTVTMLLGVFTVCWAPFF 255 R H K A G +SA+ +T + A T+ +++G F +CW PFF Sbjct: 230 EQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFF 289 Query: 256 LHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGF 315 L + + P + F + L NS ++P+IY SQE +K F+ ++ Sbjct: 290 LVMPIGSFFPD---FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL----- 341 Query: 316 RIAC 319 RI C Sbjct: 342 RIQC 345 >gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] Length = 475 Score = 93.6 bits (231), Expect = 2e-19 Identities = 88/364 (24%), Positives = 160/364 (43%), Gaps = 78/364 (21%) Query: 12 LNLNATEG-NLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSP 70 L+ NA++ N + P S +G+ + + GV+ NILVI ++ +++LHS Sbjct: 4 LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLG---NILVILSVACHRHLHSV 60 Query: 71 MYFFVCSLAVADMLVS-----MSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICIS 125 ++++ +LAVAD+L++ S+ +E + + AF R N++ ++ + Sbjct: 61 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYW-----------AFGRVFCNIWAAVDVLC 109 Query: 126 VVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGI---------- 175 AS+ L I++DRY+ + Y LRY I+T RR + +WA I Sbjct: 110 CTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPA 169 Query: 176 -----VFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLA------------------ 212 + + E YV+ + F+ L +++ +Y ++++A Sbjct: 170 PEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDS 229 Query: 213 -----RTHVKRI-AALPGASSARQRT-----------SMQGAVTVTMLLGVFTVCWAPFF 255 R H K A G +SA+ +T + A T+ +++G F +CW PFF Sbjct: 230 EQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFF 289 Query: 256 LHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGF 315 L + + P + F + L NS ++P+IY SQE +K F+ ++ Sbjct: 290 LVMPIGSFFPD---FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL----- 341 Query: 316 RIAC 319 RI C Sbjct: 342 RIQC 345 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.333 0.141 0.438 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 10,510,218 Number of Sequences: 37866 Number of extensions: 389358 Number of successful extensions: 3613 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 539 Number of HSP's successfully gapped in prelim test: 198 Number of HSP's that attempted gapping in prelim test: 1903 Number of HSP's gapped (non-prelim): 1010 length of query: 325 length of database: 18,247,518 effective HSP length: 102 effective length of query: 223 effective length of database: 14,385,186 effective search space: 3207896478 effective search space used: 3207896478 T: 11 A: 40 X1: 15 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 39 (21.6 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.