Guide to the Human Genome
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Search of human proteins with 50962882

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|50962882 G patch domain containing 8 [Homo sapiens]
         (1502 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|50962882 G patch domain containing 8 [Homo sapiens]               3042   0.0  
gi|34740327 zinc finger protein 804A [Homo sapiens]                   266   1e-70
gi|31791053 zinc finger protein 804B [Homo sapiens]                   251   5e-66
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]   133   1e-30
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]       114   5e-25
gi|42560244 peptidylprolyl isomerase G [Homo sapiens]                 109   2e-23
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]    107   9e-23
gi|50083281 KIAA1853 protein [Homo sapiens]                           103   1e-21
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]         100   1e-20
gi|60097902 filaggrin [Homo sapiens]                                   99   2e-20
gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo s...    96   3e-19
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]       95   6e-19
gi|153251865 hypothetical protein LOC84226 [Homo sapiens]              95   6e-19
gi|57864582 hornerin [Homo sapiens]                                    92   5e-18
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]         91   1e-17
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...    90   1e-17
gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]    90   1e-17
gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sap...    88   5e-17
gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sap...    88   5e-17
gi|133922600 splicing factor, arginine/serine-rich 16 [Homo sapi...    88   7e-17
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...    87   1e-16
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...    87   1e-16
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]         83   2e-15
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]                    82   3e-15
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ...    82   4e-15
gi|42741684 zinc finger protein 265 isoform 1 [Homo sapiens]           82   4e-15
gi|158854042 hypothetical protein LOC222183 [Homo sapiens]             81   7e-15
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]        80   1e-14
gi|38146113 arginine/serine-rich coiled-coil 2 isoform b [Homo s...    80   2e-14
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]    79   3e-14

>gi|50962882 G patch domain containing 8 [Homo sapiens]
          Length = 1502

 Score = 3042 bits (7886), Expect = 0.0
 Identities = 1502/1502 (100%), Positives = 1502/1502 (100%)

Query: 1    MADRFSRFNEDRDFQGNHFDQYEEGHLEIEQASLDKPIESDNIGHRLLQKHGWKLGQGLG 60
            MADRFSRFNEDRDFQGNHFDQYEEGHLEIEQASLDKPIESDNIGHRLLQKHGWKLGQGLG
Sbjct: 1    MADRFSRFNEDRDFQGNHFDQYEEGHLEIEQASLDKPIESDNIGHRLLQKHGWKLGQGLG 60

Query: 61   KSLQGRTDPIPIVVKYDVMGMGRMEMELDYAEDATERRRVLEVEKEDTEELRQKYKDYVD 120
            KSLQGRTDPIPIVVKYDVMGMGRMEMELDYAEDATERRRVLEVEKEDTEELRQKYKDYVD
Sbjct: 61   KSLQGRTDPIPIVVKYDVMGMGRMEMELDYAEDATERRRVLEVEKEDTEELRQKYKDYVD 120

Query: 121  KEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSS 180
            KEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSS
Sbjct: 121  KEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSS 180

Query: 181  RSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFKPTTVAVDEEGGEDDKDESATNSG 240
            RSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFKPTTVAVDEEGGEDDKDESATNSG
Sbjct: 181  RSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFKPTTVAVDEEGGEDDKDESATNSG 240

Query: 241  TGATASCGLGSEFSTDKGGPFTAVQITNTTGLAQAPGLASQGISFGIKNNLGTPLQKLGV 300
            TGATASCGLGSEFSTDKGGPFTAVQITNTTGLAQAPGLASQGISFGIKNNLGTPLQKLGV
Sbjct: 241  TGATASCGLGSEFSTDKGGPFTAVQITNTTGLAQAPGLASQGISFGIKNNLGTPLQKLGV 300

Query: 301  SFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKPDEKSSDQGLQKVGDSDGSSNLDGKKE 360
            SFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKPDEKSSDQGLQKVGDSDGSSNLDGKKE
Sbjct: 301  SFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKPDEKSSDQGLQKVGDSDGSSNLDGKKE 360

Query: 361  DEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQM 420
            DEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQM
Sbjct: 361  DEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQM 420

Query: 421  DGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSEPGSKA 480
            DGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSEPGSKA
Sbjct: 421  DGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSEPGSKA 480

Query: 481  EAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQEGPKHPTGPFFPV 540
            EAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQEGPKHPTGPFFPV
Sbjct: 481  EAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQEGPKHPTGPFFPV 540

Query: 541  LSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSK 600
            LSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSK
Sbjct: 541  LSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSK 600

Query: 601  DHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGR 660
            DHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGR
Sbjct: 601  DHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGR 660

Query: 661  SLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNK 720
            SLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNK
Sbjct: 661  SLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNK 720

Query: 721  SSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQD 780
            SSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQD
Sbjct: 721  SSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQD 780

Query: 781  HGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEE 840
            HGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEE
Sbjct: 781  HGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEE 840

Query: 841  EEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDR 900
            EEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDR
Sbjct: 841  EEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDR 900

Query: 901  SRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRS 960
            SRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRS
Sbjct: 901  SRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRS 960

Query: 961  RSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHS 1020
            RSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHS
Sbjct: 961  RSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHS 1020

Query: 1021 GRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDC 1080
            GRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDC
Sbjct: 1021 GRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDC 1080

Query: 1081 SPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPNKAGPKLKDPPQGYFGPKLPPSLG 1140
            SPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPNKAGPKLKDPPQGYFGPKLPPSLG
Sbjct: 1081 SPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPNKAGPKLKDPPQGYFGPKLPPSLG 1140

Query: 1141 NKPVLPLIGKLPATRKPNKKCEESGLERGEEQEQSETEEGPPGSSDALFGHQFPSEETTG 1200
            NKPVLPLIGKLPATRKPNKKCEESGLERGEEQEQSETEEGPPGSSDALFGHQFPSEETTG
Sbjct: 1141 NKPVLPLIGKLPATRKPNKKCEESGLERGEEQEQSETEEGPPGSSDALFGHQFPSEETTG 1200

Query: 1201 PLLDPPPEESKSGEATADHPVAPLGTPAHSDCYPGDPTISHNYLPDPSDGDTLESLDSSS 1260
            PLLDPPPEESKSGEATADHPVAPLGTPAHSDCYPGDPTISHNYLPDPSDGDTLESLDSSS
Sbjct: 1201 PLLDPPPEESKSGEATADHPVAPLGTPAHSDCYPGDPTISHNYLPDPSDGDTLESLDSSS 1260

Query: 1261 QPGPVESSLLPIAPDLEHFPSYAPPSGDPSIESTDGAEDASLAPLESQPITFTPEEMEKY 1320
            QPGPVESSLLPIAPDLEHFPSYAPPSGDPSIESTDGAEDASLAPLESQPITFTPEEMEKY
Sbjct: 1261 QPGPVESSLLPIAPDLEHFPSYAPPSGDPSIESTDGAEDASLAPLESQPITFTPEEMEKY 1320

Query: 1321 SKLQQAAQQHIQQQLLAKQVKAFPASAALAPATPALQPIHIQQPATASATSITTVQHAIL 1380
            SKLQQAAQQHIQQQLLAKQVKAFPASAALAPATPALQPIHIQQPATASATSITTVQHAIL
Sbjct: 1321 SKLQQAAQQHIQQQLLAKQVKAFPASAALAPATPALQPIHIQQPATASATSITTVQHAIL 1380

Query: 1381 QHHAAAAAAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATFLASHPIH 1440
            QHHAAAAAAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATFLASHPIH
Sbjct: 1381 QHHAAAAAAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATFLASHPIH 1440

Query: 1441 IIPASAIHPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSGQDLQHPPSH 1500
            IIPASAIHPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSGQDLQHPPSH
Sbjct: 1441 IIPASAIHPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSGQDLQHPPSH 1500

Query: 1501 GT 1502
            GT
Sbjct: 1501 GT 1502


>gi|34740327 zinc finger protein 804A [Homo sapiens]
          Length = 1209

 Score =  266 bits (680), Expect = 1e-70
 Identities = 214/629 (34%), Positives = 308/629 (48%), Gaps = 86/629 (13%)

Query: 114 KYKDYVDKEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQRE 173
           K  DY +KE  IAKALEDL+ANFYCELCDKQY KHQEFDNHINSYDHAHKQRLK+LKQRE
Sbjct: 35  KTLDYAEKENTIAKALEDLKANFYCELCDKQYYKHQEFDNHINSYDHAHKQRLKELKQRE 94

Query: 174 FARNVSSRSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFKPTTVAVDEEGGEDDKD 233
           FARNV+S+SRKDE+KQEKAL+RLH+LAE RK+  CAPGSGPMFK TTV V E   E  + 
Sbjct: 95  FARNVASKSRKDERKQEKALQRLHKLAELRKETVCAPGSGPMFKSTTVTVRENCNEISQR 154

Query: 234 ---ESATNSGTGATASCGLGSEFSTDKGGPFTAVQITNTTGLAQAPGLASQGISFGIKNN 290
              +S  N          + SE +T            + T +A+ P  A+   ++  KNN
Sbjct: 155 VVVDSVNNQQDFKYTL--IHSEENT-----------KDATTVAEDPESAN---NYTAKNN 198

Query: 291 ------LGTPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKPDEK--SSDQG 342
                  G    K+G SF+F KKA VKLES A+ F +++++ +   G     +   S   
Sbjct: 199 QVGDQAQGIHRHKIGFSFAFPKKASVKLESSAAAFSEYSDDASVGKGFSRKSRFVPSACH 258

Query: 343 LQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPPAHC 402
           LQ+   +D   + + K     P +       + + K   + +       E    + P+ C
Sbjct: 259 LQQSSPTDVLLSSEEKTNSFHPPE------AMCRDKETVQTQEIKEVSSEKDALLLPSFC 312

Query: 403 KVKPNFPFLLFMRASEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQ----GAEKTV 458
           K           +     D DN  +     +     S      I  + +     G + TV
Sbjct: 313 K----------FQLQLSSDADNCQNSVPLADQIPLESVVINEDIPVSGNSFELLGNKSTV 362

Query: 459 SEVSEQ-PKETSMTEPSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETS 517
            ++S       + TE +   ++A   +    +  +    S++++V+ T        K+T+
Sbjct: 363 LDMSNDCISVQATTEENVKHNEASTTEVENKNGPETLAPSNTEEVNIT------IHKKTN 416

Query: 518 LATPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFK 577
                        K    PF PVL+K  ST LQWPSE+L++T  +PSISYSCNPL FDFK
Sbjct: 417 FC-----------KRQCEPFVPVLNKHRSTVLQWPSEMLVYTTTKPSISYSCNPLCFDFK 465

Query: 578 LSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGS 637
            ++  +   K     KD+ S  K   + +  G  +  K+V  E +     G     +S +
Sbjct: 466 STKVNNNLDKNKPDLKDLCSQQKQ--EDICMGPLSDYKDVSTEGLTDYEIG-----SSKN 518

Query: 638 ACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRH--KKKKKHKKSSKHKRKHKADT 695
            CS +          S  +        K E +G+ +++   K ++ +K +  K + K DT
Sbjct: 519 KCSQVTPLLADDILSSSCDS------GKNENTGQRYKNISCKIRETEKYNFTKSQIKQDT 572

Query: 696 -EEKSSKAESGEK-----SKKRKKRKRKK 718
            +EK +K    E       K R+K+KRKK
Sbjct: 573 LDEKYNKIRLKETHEYWFHKSRRKKKRKK 601



 Score =  107 bits (266), Expect = 1e-22
 Identities = 74/194 (38%), Positives = 106/194 (54%), Gaps = 20/194 (10%)

Query: 1302 LAPLE--SQPITFTPEEMEKYSKLQQAAQQHI-QQQLLAKQVK-AFPASAALAPATPALQ 1357
            LAPL    Q +    E  +K+  +     QHI Q  +LA +VK  FP +A   P+TP LQ
Sbjct: 1024 LAPLALPEQALLIPLENHDKFKNVPCEVYQHILQPNMLANKVKFTFPPAALPPPSTP-LQ 1082

Query: 1358 PIHIQQPATASATSITTVQHAILQHHAAAAAAAIGIHP-------HPHPQPLAQVHHIPQ 1410
            P+ +QQ  +  +TS+TT+ H +LQ HAAAAAAA             PH Q L+Q+  + +
Sbjct: 1083 PLPLQQ--SLCSTSVTTIHHTVLQQHAAAAAAAAAAAAAGTFKVLQPHQQFLSQIPALTR 1140

Query: 1411 PHLTPISLSHLTHSIIPGHPATFLASHPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPR 1470
              L  +S+  +   + PG+  TF+A   + IIPAS +HP    F  +PH AL+P+LL+P 
Sbjct: 1141 TSLPQLSVGPVGPRLCPGNQPTFVAPPQMPIIPASVLHPSHLAFPSLPH-ALFPSLLSPH 1199

Query: 1471 PAAAAATALHLHPL 1484
            P     T + L PL
Sbjct: 1200 P-----TVIPLQPL 1208


>gi|31791053 zinc finger protein 804B [Homo sapiens]
          Length = 1349

 Score =  251 bits (640), Expect = 5e-66
 Identities = 185/517 (35%), Positives = 255/517 (49%), Gaps = 61/517 (11%)

Query: 117 DYVDKEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFAR 176
           D+ +K K+ AKALED++ANFYCELCDKQY KHQEFDNHINSYDHAHKQRLK+LKQREFAR
Sbjct: 37  DFAEK-KSTAKALEDVKANFYCELCDKQYHKHQEFDNHINSYDHAHKQRLKELKQREFAR 95

Query: 177 NVSSRSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFKPTTVAVDEEGGEDDKDESA 236
           NV+S+S KDEKKQEKAL+RLH+LAE R+Q+EC  G+GP +K   VA++++       +  
Sbjct: 96  NVASKSWKDEKKQEKALKRLHQLAELRQQSECVSGNGPAYKAPRVAIEKQ-----LQQGI 150

Query: 237 TNSGTGATASCGLGSEFSTDKGGPFTAVQITNTTGLAQAPGLASQGISFG-----IKNNL 291
                G   SC   +     K  P        +T   +    + +   FG       ++L
Sbjct: 151 FPIKNGRKVSCMKSALLLKGKNLPRIISDKQRSTMPNRHQLQSDRRCLFGNQVLQTSSDL 210

Query: 292 GTPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKPDEKSSDQGLQKVGDSDG 351
                + GVSF+F+KK  +KLES ASVF ++ EE T +    P  K+     +       
Sbjct: 211 SNANHRTGVSFTFSKKVHLKLESSASVFSENTEE-THDCNKSPIYKTKQTADKCKCCRFA 269

Query: 352 SSNLDGKKEDEDPQDGGSLASTL-------SKLKRMKREEGAGATEPEYYHYIPPAHCKV 404
           + +    KE E       L S L       SK+ + K +      E      I  +  K 
Sbjct: 270 NKDTHLTKEKEVNISPSHLESVLHNTISINSKILQDKHDSIDETLEDSI--GIHASFSKS 327

Query: 405 KPNFPFLLFMRASEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGA--------EK 456
             +   + F   S + +  NT   KN  E          +C+       A          
Sbjct: 328 NIHLSDVDFTPTSREKETRNTL--KNTLE----------NCVNHPCQANASFSPPNIYNH 375

Query: 457 TVSEVSEQPKETSMTEPSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKET 516
           + + +SE   E S  EPSE  S             +  +E+  + + +T+    N  +  
Sbjct: 376 SDARISECLDEFSSLEPSEQKSTVHLN-------PNSRIENREKSLDKTERVSKNVQRLV 428

Query: 517 SLATPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDF 576
             A      S+        PF  V SKD  T LQWP+ELL+FTK EP ISY CNPLYFDF
Sbjct: 429 KEACTHNVASK------PLPFLHVQSKDGHTTLQWPTELLLFTKTEPCISYGCNPLYFDF 482

Query: 577 KLSRN-------KDARTKGTEKPKDIGSSSKDHLQGL 606
           KLSRN       +D +T+  +KP ++ +  +  + GL
Sbjct: 483 KLSRNTKEDHNLEDLKTELGKKPLELKTKRESQVSGL 519



 Score =  201 bits (510), Expect = 6e-51
 Identities = 180/651 (27%), Positives = 299/651 (45%), Gaps = 57/651 (8%)

Query: 878  SDQSCYSRQRSYSDDSYSDYSD-RSRRHSKRSHDSDDSD----YASSKHRSKRHK----- 927
            S QSC SR  S  D S S  S  RS   S R + +   +    +    H  +RHK     
Sbjct: 700  SPQSCLSRYSSSLDTSPSSMSSLRSTCSSHRFNGNSRGNLLCFHKREHHSVERHKRKCLK 759

Query: 928  ---YSSSDDDYSLSCSQSRSRSRSHTR--ERSRSRGRSRSSSCSRSRSKRRSRSTTAHSW 982
               +  SDD    S  QS  +   + +  E  ++   S+   C     ++  ++    S 
Sbjct: 760  HNCFYLSDDITKSSQMQSEPQKERNCKLWESFKNEKYSKRRYCHCRERQKLGKNQQQFSG 819

Query: 983  QRSRS--YSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQ----SP 1036
             +S    Y    S+ + + S +     +   H+  +  +S  + +  +K  R+Q    SP
Sbjct: 820  LKSTRIIYCDSNSQISCTGSSKKPPNCQGTQHDRLDS-YSIEKMYYLNKSKRNQESLGSP 878

Query: 1037 HYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEK 1096
            H    G+   P K + G            +N + G    +E + +  ++  +TAK+LLE+
Sbjct: 879  HICDLGKVR-PMKCNSGN------ISCLLKNCSSGPSETTESNTAEGERTPLTAKILLER 931

Query: 1097 IQSRKVERKPSVSEEVQATPNKAGPKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRK 1156
            +Q++K + +   S  V+ + N    +L+ P Q     +L PS  N+  LPL  K+    +
Sbjct: 932  VQAKKCQEQ---SSNVEISSNSCKSELEAPSQVPCTIQLAPSGCNRQALPLSEKIQYASE 988

Query: 1157 PNKKCEESGLERGEEQEQSETEEGPPGSSDALFGHQFPSEETTG--PLLDPPPEESKSGE 1214
             ++  ++S + R  E+++S++      +   L      +  + G   L+      +   +
Sbjct: 989  -SRNDQDSAIPRTTEKDKSKSSH--TNNFTILADTDCDNHLSKGIIHLVTESQSLNIKRD 1045

Query: 1215 ATADHPVAPLGTPAHSDCYPGDPTISHNYLPDPSDGDTLESLDSSSQPGPVESSLLPIAP 1274
            AT      PL +         DP  +      PS+  T  +  + +Q   +   L  ++ 
Sbjct: 1046 ATTKEQSKPLISEIQPFIQSCDPVPNEFPGAFPSNKYTGVTDSTETQEDQINLDLQDVSM 1105

Query: 1275 DLEHFPSYAPPSGDPSIESTDGAEDA------SLAP-LESQPITFTPEEMEKYSKLQQAA 1327
             + H         D +++  D  ED       S++P L  QPITF+P+E++KY  LQ  A
Sbjct: 1106 HINHVEGNINSYYDRTMQKPDKVEDGLEMCHKSISPPLIQQPITFSPDEIDKYKILQLQA 1165

Query: 1328 QQHIQQQLLAKQVKAFPASA--ALAPATPALQPIHIQQPATASATSITTVQHAILQHHAA 1385
            QQH+Q+QLL+K ++  PA+   A +PA+  +Q + + Q      TSITT+ H  LQH A 
Sbjct: 1166 QQHMQKQLLSKHLRVLPAAGPTAFSPAS-TVQTVPVHQH-----TSITTIHHTFLQHFAV 1219

Query: 1386 AAAAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATFLASHPIHIIPAS 1445
            +A+    +  H    P+A +H + Q H +PIS S LT +IIP HP TFLA HP+H++ A+
Sbjct: 1220 SAS----LSSHSSHLPIAHLHPLSQAHFSPISFSTLTPTIIPAHP-TFLAGHPLHLVAAT 1274

Query: 1446 AIHPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSGQDLQH 1496
              HP   T  P+P  A  PTL  P    A  + +HL+PL+ P+F GQD  H
Sbjct: 1275 PFHPSHITLQPLPPTAFIPTLFGPHLNPATTSIIHLNPLIQPVFQGQDFCH 1325


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score =  133 bits (335), Expect = 1e-30
 Identities = 187/870 (21%), Positives = 295/870 (33%), Gaps = 50/870 (5%)

Query: 224  DEEGGEDDKD-ESATNSGTGATASCGLGSEFSTDKGGPFTAVQITNTTGLAQAPGLASQG 282
            DE  G DD + ES  NS +   AS           G      +  ++   +      S G
Sbjct: 469  DESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNG 528

Query: 283  ISFGIKNNLGTPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKPDEKSSDQG 342
               G   N        G   S +  +     S +S   D ++  +S+  +  D  SSD  
Sbjct: 529  N--GNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSD 586

Query: 343  LQKVGDSDGS--SNLDGKKEDEDPQDGG-SLASTLSKLKRMKREEGAGATEPEYYHYIPP 399
                 DSD S  SN     +  D  D   S  S+ SK    K E  +  ++         
Sbjct: 587  SSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDS-------- 638

Query: 400  AHCKVKPNFPFLLFMRASEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVS 459
                 K +        +S+  D  ++++  N+ +S   SS    S   + +S  ++ + S
Sbjct: 639  -----KSDSSDSNSSDSSDNSDSSDSSNSSNSSDS-SDSSDSSDSSSSSDSSNSSDSSDS 692

Query: 460  EVSEQPKETSMTEPSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLA 519
              S    E+S +  S     +++  +   + SD    + S     +   +S+ S ++S +
Sbjct: 693  SDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNS 752

Query: 520  TPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLS 579
            + +   S       +       S D S +    S+    + +  S + S +    +   S
Sbjct: 753  SDSSDSSDSSNSSDSSD-----SSDSSDS----SDSSNSSDSNDSSNSSDSSDSSNSSDS 803

Query: 580  RNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSAC 639
             N    +  ++      S+S D     D  + + S +         S    D+ +S  + 
Sbjct: 804  SNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSS---DSSDGSDSDSSNRSD 860

Query: 640  SGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKS 699
            S  +      S  S + D+  S  S    S  S           S      + +D+ + S
Sbjct: 861  SSNSSDSSDSSDSSNSSDSSDS--SDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSS 918

Query: 700  SKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSL 759
            + ++S E S          + +S+ +            S S         +  +S   S 
Sbjct: 919  NSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSD 978

Query: 760  PAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDED 819
             +    S    +    S S D        +   SS    +    +S  S  S  SS   D
Sbjct: 979  SSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSD 1038

Query: 820  SDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSD 879
            S D+S       S    +  +  + S S  S   S S     S  SS  S SS+S  SSD
Sbjct: 1039 SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSD 1098

Query: 880  QSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDD--DYSL 937
             S  S     SD S S  S  S   S  S  SD SD + S + S     S S D  D S 
Sbjct: 1099 SSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSD 1158

Query: 938  SCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTR 997
            S   S S   S + + S S   S SS  S S     S  ++  S     S S D S S+ 
Sbjct: 1159 SSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1218

Query: 998  SPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDD 1057
            S S  S S   S  +ES +   S            S S     S          D   D 
Sbjct: 1219 S-SDSSDSSDSSDSNESSDSSDS------------SDSSDSSNSSDSSDSSDSSDSTSDS 1265

Query: 1058 SKATGPPSQNSNIGTGRGSEGDCSPEDKNS 1087
            +  +   S++ N G   GS+ D   E  +S
Sbjct: 1266 NDESDSQSKSGN-GNNNGSDSDSDSEGSDS 1294



 Score =  117 bits (292), Expect = 1e-25
 Identities = 207/965 (21%), Positives = 323/965 (33%), Gaps = 104/965 (10%)

Query: 178  VSSRSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMF-------KPTTVAVDE---EG 227
            +   S ++E    +   +++      K+AE  PG+G           P+    DE   EG
Sbjct: 199  IIENSCRNEGNTSEITPQINSKRNGTKEAEVTPGTGEDAGLDNSDGSPSGNGADEDEDEG 258

Query: 228  GEDDKDESATNSGTGATASCGL-GSEFSTDKGGPFTAVQITNTTGLAQAPG-------LA 279
              DD+DE A N    +  S G  G +   +     +  Q +++       G       + 
Sbjct: 259  SGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVD 318

Query: 280  SQGISFGIKNNLGTPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKPDEKSS 339
                S   +N+ G P           +K   + ES     K      T E  T    KS 
Sbjct: 319  GDKTSKSEENSAGIPEDNGSQRIEDTQKLNHR-ES-----KRVENRITKESETHAVGKSQ 372

Query: 340  DQGLQKVGDSDGSSNLDGK--KEDEDPQDGGSLASTLSKLKRMKREEGAGATEP----EY 393
            D+G++  G S G+ N+  +  K +E  +D G     L K     + E      P    E 
Sbjct: 373  DKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEP 432

Query: 394  YHYIPPAHCKVKPN---FPFLLFMRASEQMDGDNTTHPKNAPE----------SKKG--- 437
             + +  ++     N   +    F   S Q D  N++   N  +          S +G   
Sbjct: 433  GNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDAS 492

Query: 438  -SSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSEPGSKAEAKKALG--------G 488
             +S + K     + S+GAE   S+ +     +        G+    K   G         
Sbjct: 493  YNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDS 552

Query: 489  DVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQEGPKHPTGPFFPVLSKDESTA 548
            D SD S  S S   S++   +SNSS ++  +     +S +             S D S +
Sbjct: 553  DSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSD-----------SSDSSNS 601

Query: 549  LQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDP 608
                      + +  S   S +    D   S++  ++++      D  S S D     D 
Sbjct: 602  ----------SDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDS-NSSDS 650

Query: 609  GEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPG----GSHGSETEDTGRSLPS 664
             + + S +         S    D+  S S+    N  +       S+ SE+ D+  S  S
Sbjct: 651  SDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDS 710

Query: 665  KKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAP 724
                S  S        +  SS     + +D+ + S+ ++S + S          + SS  
Sbjct: 711  DSSDSSDS-------SNSNSSDSDSSNSSDSSDSSNSSDSSDSSDS--------SNSSDS 755

Query: 725  ADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGR 784
            +DS            S +          DS   S  ++   S    +    S S D    
Sbjct: 756  SDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDS 815

Query: 785  KHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEED 844
                    S     + +  SS SS  S  S   + SD  SS+R    + S  S+  +  +
Sbjct: 816  SDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSN 875

Query: 845  SG-SEHSRSRSRSGRRHSSHRSSRRSYSSSSDA--SSDQSCYSRQRSYSDDSYSDYSDRS 901
            S  S  S   + S     S  SS  S S SSD+  SSD S  S     S+ S S  +  S
Sbjct: 876  SSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNS 935

Query: 902  RRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSR 961
               S  S  SD SD ++S   S     +SSD   S   S S S   S +   S S   S 
Sbjct: 936  SDSSNSSDSSDSSDSSNSSDSS-----NSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSD 990

Query: 962  SSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSG 1021
            SS  S S     S  ++  S     S S D S S+ S +    S        S     S 
Sbjct: 991  SSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSD 1050

Query: 1022 RRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCS 1081
              D   S      S     S   +     D     DS  +   S +S+      S     
Sbjct: 1051 SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSD 1110

Query: 1082 PEDKN 1086
              D +
Sbjct: 1111 SSDSS 1115



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 131/715 (18%), Positives = 241/715 (33%), Gaps = 27/715 (3%)

Query: 224  DEEGGEDDKDESATNSGTGATASCGLGSEFSTDKGGPFTAVQITNTTGLAQAPGLASQGI 283
            D     D  D S + S +  + S    S+  +D     ++    N+     +    S   
Sbjct: 609  DSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDS 668

Query: 284  SFGIKNNLGTPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKPDEKSSDQGL 343
            S    ++  +       S   +  +     S +S   D ++  +S+     +  SSD   
Sbjct: 669  SDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDS 728

Query: 344  QKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPPAHCK 403
                DS  SSN     +  D  +    + +          + + +++         ++  
Sbjct: 729  SNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDS 788

Query: 404  VKPNFPFLLFMRASEQMDGDNTTHPKNAPESKKGS----SPKPKSCIKAAASQGAEKTVS 459
                        +S+  D  N++   N+ +S   S    S    S   + +S  ++ + S
Sbjct: 789  ----------SNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNS 838

Query: 460  EVSEQPKETSMTEPSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLA 519
              S    ++S    S+  +++++  +   D SD S  S+S   S++     +S+   S  
Sbjct: 839  SDSSDSSDSSDGSDSDSSNRSDSSNS--SDSSDSSDSSNSSDSSDSSDSNESSNSSDSSD 896

Query: 520  TPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLS 579
            +    +S       +       +  +S+     S+    + +  S   S +    +   S
Sbjct: 897  SSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDS 956

Query: 580  RNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAP-ASGSA 638
             N    +  ++      S S D     D  + + S +        +S    D+  +S S+
Sbjct: 957  SNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSS 1016

Query: 639  CSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEK 698
             S  +      S+ S++ D+  S  S  + S  S           S        +D+ + 
Sbjct: 1017 NSSDSSNSSDSSNSSDSSDSSDSSDSS-DSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDS 1075

Query: 699  SSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRS 758
            S  ++S E S          + SS  +DS            S +          DS   S
Sbjct: 1076 SDSSDSSESSDSSDSSN--SSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1133

Query: 759  LPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDE 818
              ++  +S    +    S S D        +   SS    +    +S  S  S  SS   
Sbjct: 1134 DSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSS 1193

Query: 819  DSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASS 878
            DS D+S       S       +  + S S  S   S S     S  SS  S SS+S  SS
Sbjct: 1194 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSS 1253

Query: 879  DQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDD 933
            D        S S DS SD +D S   SK  + +++   + S        +S+SDD
Sbjct: 1254 DS-------SDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTSDD 1301



 Score = 94.4 bits (233), Expect = 8e-19
 Identities = 124/553 (22%), Positives = 205/553 (37%), Gaps = 65/553 (11%)

Query: 583  DARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPA-SGSACSG 641
            +++  GT++ +    + +D   GLD  + + S     E     SG   D  A +G   S 
Sbjct: 218  NSKRNGTKEAEVTPGTGED--AGLDNSDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSN 275

Query: 642  LNKQEPGGSHGSETE---DTGRSLPSKK--ERSGKSHRHKKKKKHKKSSKHKRKHKADTE 696
             +K + G  HG E +     G++  SK+  +  GK   H +    K S   +       +
Sbjct: 276  NSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPED 335

Query: 697  EKSSKAESGEK-----SKKRKKRKRKKNKSSAPADSE-RGPKPEPPGSGSPAPPR---RR 747
              S + E  +K     SK+ + R  K++++ A   S+ +G + + P SG+    +   + 
Sbjct: 336  NGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKG 395

Query: 748  RRAQDDSQRRSL------------------PAEEGSSGKK--------DEGGGGSSSQDH 781
               ++D  +  +                  P ++   G K        D    G  S D 
Sbjct: 396  NEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDF 455

Query: 782  GGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEE 841
              +  +G+ P SS +       +S S + S  S GD   +   S      S S+ +E+++
Sbjct: 456  DDKSMQGDDPNSSDESNGNDDANSESDNNSS-SRGDASYNSDESKDNGNGSDSKGAEDDD 514

Query: 842  EE---DSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYS 898
             +   D+ +  S     +G   +    S +  S SSD+ S  S  S     SD S SD S
Sbjct: 515  SDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDS--SNSSDSSDSSDSDSS 572

Query: 899  DRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSD----DDYSLSCSQSRSRSRSHTRERS 954
            D +      S DSD SD + S      +   SSD     D S S   S S+S S   E  
Sbjct: 573  DSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESD 632

Query: 955  RSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHES 1014
             S   S+S S   + S     S ++ S   S S     S  +   S  S S   S   +S
Sbjct: 633  SSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDS 692

Query: 1015 PEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGR 1074
             +  +S            S+S     S   +     D    + S +    S +S+  +  
Sbjct: 693  SDSSNS------------SESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNS 740

Query: 1075 GSEGDCSPEDKNS 1087
                D S    +S
Sbjct: 741  SDSSDSSDSSNSS 753


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score =  114 bits (286), Expect = 5e-25
 Identities = 186/814 (22%), Positives = 294/814 (36%), Gaps = 75/814 (9%)

Query: 288  KNNLGTPLQ-----KLGVSFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKPDEKSSDQG 342
            +N+ G+PL+      LG   +    + VK E +   F +  E       T P     +Q 
Sbjct: 1324 ENSFGSPLEFRNSGPLGTEMNTGFSSEVK-EDLNGPFLNQLE-------TDPSLDMKEQS 1375

Query: 343  LQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRM-KREEGAGATEPEYYHYIP--P 399
             +  G S    + D  ++     +    +  L  + R   RE  + A+ PE    +P  P
Sbjct: 1376 TRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTP 1435

Query: 400  AHCKVKPNFPFLLFMRASEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVS 459
            +      + P L         DG  T     +  S  GSSP  K  I    S+G     S
Sbjct: 1436 SRRSRSGSSPGL--------RDGSGTP----SRHSLSGSSPGMKD-IPRTPSRGR----S 1478

Query: 460  EVSEQPKETSMTEPSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLA 519
            E    P+  ++ +   P S++ +   L         E            ES+  ++T   
Sbjct: 1479 ECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGS--------ESSVDQKTVAR 1530

Query: 520  TPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLS 579
            TP G+ S+ G           L    S + Q  SE      +  S + +  PL    +  
Sbjct: 1531 TPLGQRSRSGSSQE-------LDVKPSASPQERSES---DSSPDSKAKTRTPLRQRSRSG 1580

Query: 580  RNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSAC 639
             + +  +K    P+   S S   ++      P            ++   R     S S  
Sbjct: 1581 SSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGS 1640

Query: 640  SGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKS 699
            S  +K       GS + ++    P K   + +  R   + K K  +  +R+    + E +
Sbjct: 1641 S--SKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELT 1698

Query: 700  SKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSL 759
             KA    +S  R      + +S  P    R P    P     +   RRRR+    + ++ 
Sbjct: 1699 RKARLSRRS--RSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTT 1756

Query: 760  PAEEGSSGKKDEGGGGSSSQDHGG------RKHKGELPPSSCQRRAGTKRSSRSSHRSQP 813
                 S   K  G   S S+          R+ +     S+ +RR  ++  SR + R + 
Sbjct: 1757 SRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRG 1816

Query: 814  SSG-------DEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSS 866
             SG        ++S   SS R   +S +  +  +      S     RSRS    ++HR S
Sbjct: 1817 GSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRS 1876

Query: 867  RRSYS--SSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSK 924
            R      S   + S  S  SR+RS S  S +    RSR        S       ++ RS+
Sbjct: 1877 RSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSR 1936

Query: 925  RHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSK-RRSRSTTAHSWQ 983
                ++     S +   +R RSRS T   +R R RSR+S  +R RS+ R S  T   S  
Sbjct: 1937 SRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRS 1996

Query: 984  RSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGR 1043
            R+   +R RSRS  SP  R  SR R+    +   R   R   +  K  RS+SP   R  R
Sbjct: 1997 RTSPVTRRRSRSRTSPVTRRRSRSRT--PPAIRRRSRSRTPLLPRKRSRSRSPLAIR--R 2052

Query: 1044 GEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSE 1077
                      RG  S    PP+      +G  S+
Sbjct: 2053 RSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSD 2086



 Score =  112 bits (279), Expect = 4e-24
 Identities = 316/1430 (22%), Positives = 477/1430 (33%), Gaps = 225/1430 (15%)

Query: 229  EDDKDESATNSGTGATASCGLGSEFSTDKGGPFTAVQITNTTGLAQ-APGLASQGISFGI 287
            ++   +S   S  G+ + C  G + ST  G  +  V      G +Q +P   S   S  +
Sbjct: 1018 QEKSKDSLVQSCPGSLSLCA-GVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEV 1076

Query: 288  KNNLGTPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKPDE-KSSDQGLQKV 346
            +       Q    S S   K+    +   S       E  S    + D  + S   + K 
Sbjct: 1077 R-------QSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKS 1129

Query: 347  GDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPPAHCKVKP 406
            G S   S            D  SL    S+L+  + +E       E     PP   + K 
Sbjct: 1130 GMSPEQSRFQSDSSSYPTVDSNSLLGQ-SRLETAESKEKMALPPQEDATASPP---RQKD 1185

Query: 407  NF-PFLLFMRASEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQP 465
             F PF +  R    +   +T        S  GSSP+ K    A  +   ++ + EV E+ 
Sbjct: 1186 KFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKS 1245

Query: 466  KETS--------------MTEPSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCES- 510
            +E +               T   E   + E + A+   +     ++  + V    M  S 
Sbjct: 1246 EEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSW 1305

Query: 511  ----------------------NSSKETSLATPAGKE-----SQEGPKHPTGPFFPVLSK 543
                                   S  E   + P G E     S E  +   GPF   L  
Sbjct: 1306 GGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLET 1365

Query: 544  DESTALQ-----------------------------WPSELLIFTKAEPSISYSCNPLYF 574
            D S  ++                               S +L      PS   S +    
Sbjct: 1366 DPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSP 1425

Query: 575  DFK--LSRNKDARTKGTEKP---KDIGSSSKDHLQGLDPG-------------EPNKSKE 616
            + K  L R    R++    P      G+ S+  L G  PG             E + S E
Sbjct: 1426 EMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPE 1485

Query: 617  VGG-EKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHR- 674
                 +  R       +P   + C    ++  G     + +   R+   ++ RSG S   
Sbjct: 1486 PKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQEL 1545

Query: 675  -------HKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAP--- 724
                    +++ +   S   K K +    ++S    S E   K +   R+    S+P   
Sbjct: 1546 DVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVK 1605

Query: 725  --------ADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGS 776
                    A S     PEP      A PRR R       R   P    S+    E    S
Sbjct: 1606 DKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKS 1665

Query: 777  SSQDHGGR-----KHKGELPPSSCQRRAGTK--RSSRSSHRSQPSSGDEDSDDASSHRLH 829
             +   G R     K K   PP     R+  +  R +R S RS+ +S   ++   +  R H
Sbjct: 1666 RTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPR-H 1724

Query: 830  QKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSY 889
            ++SPS  S E  E+   S   RS S    + +S R   RS S            SR+   
Sbjct: 1725 RRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRG--RSPSPKPRGLQRSRSRSRREKT 1782

Query: 890  SDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHR--SKRHKYSSSDDDYSLSCSQSRSRSR 947
                  D S  S+  S+R   S      + + R  S  H  S +  + S + S+ R R R
Sbjct: 1783 RTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSR-RRRGR 1841

Query: 948  SHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRS--YSRDRSRSTRSP------ 999
            S T   SR R RSR+S     RS+ R+ S   H   RSR+   SR RSRS  SP      
Sbjct: 1842 SRTPPTSRKRSRSRTSPAPWKRSRSRA-SPATHRRSRSRTPLISRRRSRSRTSPVSRRRS 1900

Query: 1000 -SQRSGSRKRSWGHESP--EERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGD 1056
             S+ S +R+RS    SP    R   R   +  +  RS++P   R  R   P         
Sbjct: 1901 RSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTP----PVTRR 1956

Query: 1057 DSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATP 1116
             S++  PP       T R S    SP  +          + ++  V R+ S S     T 
Sbjct: 1957 RSRSRTPPV------TRRRSRSRTSPITRRR-------SRSRTSPVTRRRSRSRTSPVTR 2003

Query: 1117 NKAGPKLKDPPQGYFGPKLPPSLGNK-----PVLPLIGKLPATRKP--NKKCEESGLERG 1169
             ++  +     +     + PP++  +     P+LP   K   +R P   ++   S   R 
Sbjct: 2004 RRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLP--RKRSRSRSPLAIRRRSRSRTPRT 2061

Query: 1170 EEQEQSETEEGPPGSSDALFGHQFPSEETTGPLLDPPPEESKSGEATADHPVAPLGTPAH 1229
               ++S T   P     +  G    S         PP   + SG  T   PVA     + 
Sbjct: 2062 ARGKRSLTRSPPAIRRRSASG----SSSDRSRSATPPATRNHSGSRTP--PVAL--NSSR 2113

Query: 1230 SDCYPGDPTISHNYLPDPSDGDTLESLDSSSQP--------GPVESSLLPIAPDLEHFPS 1281
              C+   P++S   L        LE L SS  P        G +     P  PD  H  +
Sbjct: 2114 MSCF-SRPSMSPTPLDRCRSPGMLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPD--HQRT 2170

Query: 1282 YAPPSGDPS-------------IESTDGAEDASLAPLESQPITFTPEEMEKYSKLQQAAQ 1328
              P +   S                      A LA   SQ     P        L+ A  
Sbjct: 2171 SVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVP-----LMSLRTAPA 2225

Query: 1329 QHIQQQLLAKQVKAFPASAALAPATP-ALQPIHIQQPATASATSITTVQHAILQHHAAAA 1387
             ++  ++ A    A   ++A  PA P A+     + PA A+A ++ + + A+      A 
Sbjct: 2226 ANLASRIPAASAAAMNLASARTPAIPTAVNLADSRTPAAAAAMNLASPRTAV------AP 2279

Query: 1388 AAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATFLASHPIHIIPASAI 1447
            +A     P     P   +     P    ++   LT S  P   A + +S      PASA 
Sbjct: 2280 SAVNLADPRTPTAPAVNLAGARTP--AALAALSLTGSGTPPTAANYPSSSRTPQAPASAN 2337

Query: 1448 HPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSGQDLQHP 1497
              GP +     HA     +   R AAA A A      + P  SG +L  P
Sbjct: 2338 LVGPRS----AHATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSP 2383



 Score =  111 bits (277), Expect = 6e-24
 Identities = 137/566 (24%), Positives = 214/566 (37%), Gaps = 48/566 (8%)

Query: 593  KDIGSSSKDHLQGLDPG--EPNKSKEVGGEKI--VRSSGGRMDAPASGSACSGLNKQEPG 648
            KD+    K+   G  P   E ++  E+  +K   +R++ G  D+   GS+     +    
Sbjct: 101  KDVNPGGKEETPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREA 160

Query: 649  GSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKS 708
                 E       +  ++  S +S   K+KKK KK  + +R   +    +  K+   +K 
Sbjct: 161  KQPAPEPPKPYSLV--RESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKH 218

Query: 709  KKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGK 768
            +   + K++K++S  P    +    +   S S  P  + RRA   +   S  + + S  +
Sbjct: 219  RSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSR 278

Query: 769  KDEGG--------GGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDS 820
                          G S     GR+ +G+ P S     +  + SS  +   QPSS  ED 
Sbjct: 279  SRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDK 338

Query: 821  DDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRS-------SRRSYSSS 873
            D        +KS ++ S   E   +G E          RH            S+   +  
Sbjct: 339  DKDKK----EKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPP 394

Query: 874  SDAS--SDQSCYSRQRSYSDDSYSDYSDRS------RRHSKRSHDSDDSDYASSKHR--- 922
            S+AS   D+S           S S+ S  S       RH+  S +S     A   HR   
Sbjct: 395  SEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREIS 454

Query: 923  ------SKRHKYSSSDDDYSLSCSQSRSRSRS-HTRERSRSRGRSRSS-SCSRSRSKRRS 974
                  ++ H  +  D  +S + S+   RSRS  T +R RSR R+ +    SRSRS +  
Sbjct: 455  SSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWR 514

Query: 975  RSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQ 1034
            RS +A  W RSRS  R R RS RSP +   SR R+             R   RS   R +
Sbjct: 515  RSRSAQRWGRSRSPQR-RGRS-RSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGR 572

Query: 1035 SPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLL 1094
            S     + RG    +    R   S+        S     RG     +P  + S T   + 
Sbjct: 573  SRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVR 632

Query: 1095 EKIQSRKVERKPSVSEEVQATPNKAG 1120
             + +SR   R+   S     TP + G
Sbjct: 633  RRSRSRSPARRSGRSR--SRTPARRG 656



 Score =  110 bits (274), Expect = 1e-23
 Identities = 210/882 (23%), Positives = 317/882 (35%), Gaps = 135/882 (15%)

Query: 428  PKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSEPGSKAEAKKALG 487
            PK+  +SK     + +S   A  S+ A ++ S  S    +TS +      +K       G
Sbjct: 234  PKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAG 293

Query: 488  GDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQEGPKHPTGPF--FPVLSKDE 545
                  S  S  +   +    E  +   TS   P+  E+    K P+ P+       K++
Sbjct: 294  ---RSPSPASGRRGEGDAPFSEPGT---TSTQRPSSPET--ATKQPSSPYEDKDKDKKEK 345

Query: 546  STALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQG 605
            S     PS     T  EP    +  PL  +         R  G+ +P      S++ +  
Sbjct: 346  SATRPSPSPERSSTGPEPP---APTPLLAE---------RHGGSPQPLATTPLSQEPVNP 393

Query: 606  LDPGEP--NKSKEVGGEKIVRSSGGRMDAPA------SGSACSGLNKQEPGGSHGSETED 657
                 P  ++S     EK+ +SS      P+      S  A S     +P  + GS  E 
Sbjct: 394  PSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREI 453

Query: 658  TGRSLPSKKERS------GKSHRHKKKKKHKKS----SKHKRKHKADTEEKSSKAESGEK 707
            +  S P+ K RS       KSH H   ++  +S    +  + + ++ T  K   + S   
Sbjct: 454  S--SSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSP 511

Query: 708  SKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSG 767
              +R +  ++  +S +P    R   P+ PG       +RR R++   + RS      + G
Sbjct: 512  QWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRG 571

Query: 768  KKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHR 827
            +       S S+    R       P+  + R+ T    RS  R+    G   S   +  R
Sbjct: 572  R-------SRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRR 624

Query: 828  LHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQR 887
               +SP +               RSRSRS  R S    SR         S   +   R R
Sbjct: 625  SRTRSPVR--------------RRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSR 670

Query: 888  SYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRS--- 944
            S +            R S RS     +    S+ R+ R              S+SRS   
Sbjct: 671  SRT----------PARRSGRSRSRTPARRGRSRSRTPRR-----------GRSRSRSLVR 709

Query: 945  RSRSHTRERSRSRGRSRSSSCSRSRSK---RRSRSTTAHSWQRSRSYSRDRSRSTRSPSQ 1001
            R RSH+R   R RGRS SSS  +++S+   RRSRS ++   ++SR  SR RSRS  SP  
Sbjct: 710  RGRSHSRTPQR-RGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSR-RSRSLSSPRS 767

Query: 1002 RSGSR---KRSWGHESPEERHSGRRDFIRSKIYRSQ-------SPHYFRSGRGEGPGKKD 1051
            ++ SR   +RS    SP  +   +    RS+   SQ        P   RS     P +K 
Sbjct: 768  KAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKS 827

Query: 1052 DGRGDDSKATGPPSQNSNIGTGRGSEGDCSPE-DKNSVTAKLLLEKIQSRKVERKPSVSE 1110
                  S ++  P      GT        SP+ ++ SVT        Q R         E
Sbjct: 828  KTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTP-------QRRSCFESSPDPE 880

Query: 1111 EVQATPNKAGPKLKDPP--QGYFGPKLPPSLGNKPVLPLIGKLPATRKPNKKCEESGLER 1168
                TP++       PP  +    P+  PS  + P      K+ A   P ++        
Sbjct: 881  LKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQ----PKVKAIISPRQRSHSGSSSP 936

Query: 1169 GEEQEQSETEEGPPGSSDALFGHQFPSEETTGPLLDPPPEESKSGEATADHPVAPLGTP- 1227
               +  S T    P  S ++     P       LL   P  S SG ++ D  V P   P 
Sbjct: 937  SPSRVTSRT---TPRRSRSV----SPCSNVESRLL---PRYSHSGSSSPDTKVKPETPPR 986

Query: 1228 -AHSDCYPGDPTISHNYLPDPSDGDTLESLDSSSQPGPVESS 1268
             +HS      P +     P P       SL  S  P P E S
Sbjct: 987  QSHSGSISPYPKVKAQTPPGP-------SLSGSKSPCPQEKS 1021



 Score =  105 bits (263), Expect = 3e-22
 Identities = 204/903 (22%), Positives = 314/903 (34%), Gaps = 143/903 (15%)

Query: 580  RNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSAC 639
            R ++A+    E PK   S  ++      P    K K+   ++  RS         S S  
Sbjct: 156  RAREAKQPAPEPPKPY-SLVRESSSSRSPTPKQKKKKKKKDRGRRSE--------SSSPR 206

Query: 640  SGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKS 699
                K      H SE+E   R   S   +S +  + KK+K+ + ++   +  +A     +
Sbjct: 207  RERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSA 266

Query: 700  SKAESGEKSKKRKKRKRKKN-------KSSAPADSERGPKPEPPGSGSPAPPRRRRRAQD 752
              A S + S+ R +    K        +S +PA   RG    P         +R    + 
Sbjct: 267  DSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPET 326

Query: 753  DSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSS----CQRRAGTKRSSRSS 808
             +++ S P E+    KK++     S      R   G  PP+      +R  G+ +   ++
Sbjct: 327  ATKQPSSPYEDKDKDKKEKSATRPSPSPE--RSSTGPEPPAPTPLLAERHGGSPQPLATT 384

Query: 809  HRSQ-----PSSGDEDSDDA---SSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGR-- 858
              SQ     PS      D +   S  +L Q S S+ S    +    S H+ S   S +  
Sbjct: 385  PLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPA 444

Query: 859  -RHSSHR-------SSRRSYSSSSDASSDQSCYSRQ--RSYSDDSYSDYSDRSRRHSKRS 908
                SHR       S  RS+  +    S     SR+  RS S  +      RSR  +KR 
Sbjct: 445  PAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRG 504

Query: 909  HDSDDSD----------YASSKHRSKRHK--------YSSSDDDYSLSCSQSRSRSRSH- 949
            H    S           +  S+   +R +        +S S +      S+S  R RSH 
Sbjct: 505  HSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHS 564

Query: 950  ----TRERSRSR-----GRSRSSSCSRSRS------KRRSRSTTAHSWQRSRSYSRDRSR 994
                TR RSRSR     GRSRS + +R RS      +RRSRS T     RSRS +  R R
Sbjct: 565  RSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRR 624

Query: 995  S-----------TRSPSQRSG-----------------------SRKRSWGHES--PEER 1018
            S           +RSP++RSG                       SR R+    S     R
Sbjct: 625  SRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSR 684

Query: 1019 HSGRRDFIRSKI---YRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRG 1075
               RR   RS+     RS+S    R GR      +  GR   S      S+ S     R 
Sbjct: 685  TPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQ----RR 740

Query: 1076 SEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPNKAGPKLKD---PPQGYFG 1132
            S  + SPE K S  +      + S + + K  +S     + +   PK K    P +   G
Sbjct: 741  SRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSG 800

Query: 1133 PKLPPSLGNKPVLPLIGKLPATRKPNKKCE-ESGLERGEEQEQSETEEGPPGSSDALFGH 1191
               P +    P  P   +  ++  P +K +  S           + + G P    ++   
Sbjct: 801  SSQPKAKSRTP--PRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSP 858

Query: 1192 QFPSEETTGPLLDPPPEESKSGEATADHPVAPLGTPAHSDCYPGDPTISHNYLPDPSDGD 1251
            Q   +  T       P+     E++ D P     TP+   C    P    +  P      
Sbjct: 859  QANEQSVT-------PQRRSCFESSPD-PELKSRTPSRHSCSGSSPPRVKSSTP------ 904

Query: 1252 TLESLDSSSQPGPVESSLLPIAPDLEHFPSYAPPSGDPSIESTDGAEDASLAPLESQPIT 1311
              +S   SS P P   ++  I+P        + PS       T      S++P  +    
Sbjct: 905  PRQSPSRSSSPQPKVKAI--ISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESR 962

Query: 1312 FTPEEMEKYSKL--QQAAQQHIQQQLLAKQVKAFPASAALAPATPALQPIHIQQPATASA 1369
              P      S     +   +   +Q  +  +  +P   A  P  P+L       P   S 
Sbjct: 963  LLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSK 1022

Query: 1370 TSI 1372
             S+
Sbjct: 1023 DSL 1025



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 97/362 (26%), Positives = 123/362 (33%), Gaps = 69/362 (19%)

Query: 704  SGEKSKKRKKRKRKKNKSSAPADS----ERGPKPE------------PPGSGSPAPPRRR 747
            SG  S     R R +   SAP+ S    ER P P             PP    P  P   
Sbjct: 2394 SGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPS 2453

Query: 748  RRAQDDSQRRSLPAEEGSSGKKDEGGGG-----SSSQDHGG----------RKHKGELPP 792
              A  D  R  +      +G +    G      SS+ DH G              GE P 
Sbjct: 2454 --AFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPA 2511

Query: 793  SSCQRR---------AGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKS----------- 832
            S+  ++         A  +RSS SS  S  SS    S  +SS      S           
Sbjct: 2512 STGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQ 2571

Query: 833  --------PSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYS 884
                    PS     +E    G     + ++  RR SS  SS  S SSSS +SS  S  S
Sbjct: 2572 PEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSS 2631

Query: 885  RQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSK-------HRSKRHKYSSSDDDYSL 937
               S S  S S  S  S   +K    +     +  K        RS R    S  D  SL
Sbjct: 2632 SSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSL 2691

Query: 938  SCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTR 997
            S S    R R   +   R +  S S   SR   +  SRS +    + + S    R RS+R
Sbjct: 2692 SYSPVERR-RPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRHRSSR 2750

Query: 998  SP 999
            SP
Sbjct: 2751 SP 2752



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 62/245 (25%), Positives = 93/245 (37%), Gaps = 21/245 (8%)

Query: 590  EKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGG 649
            E P   G+     L  L P +  +S          SS     + +S S+ S  +  E G 
Sbjct: 2508 EPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSE-GS 2566

Query: 650  SHGSETEDTGRSLPSKKERSGKSHRH--------KKKKKHKKSSKHKRKHKADTEEKSSK 701
            S   + E   + +PS      ++ R          K+K+   SS       + +   SS 
Sbjct: 2567 SLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSS 2626

Query: 702  AESGEKSKKRKKRKRKKNKSSAPADSERGPK--PEPPGSGSPAPPRRRRRAQD---DSQR 756
            + S   S          + SS+P+ ++ GP+  P+P     P P  RR R+     DS R
Sbjct: 2627 SSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLR 2686

Query: 757  --RSL---PAE-EGSSGKKDEGGGGSSSQDHGGRK-HKGELPPSSCQRRAGTKRSSRSSH 809
              RSL   P E    S +       SSS + G R+  +G+    S +RR  T       H
Sbjct: 2687 DSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRH 2746

Query: 810  RSQPS 814
            RS  S
Sbjct: 2747 RSSRS 2751



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 199/986 (20%), Positives = 330/986 (33%), Gaps = 139/986 (14%)

Query: 415  RASEQMDGDNTTHPKNAPESKKG--------SSPKPKSCIKAAASQGAEKTVSEVSEQPK 466
            R ++       +   ++PE KK         S   P+S  KA +     +++S  S  PK
Sbjct: 730  RKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRS--KAKSRLSLRRSLSGSSPCPK 787

Query: 467  ETSMTEPSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKES 526
            + S T P    S +   KA       +S  S S    +     S  S  +S   P  K  
Sbjct: 788  QKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVK-- 845

Query: 527  QEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDART 586
              G     G      + ++S   Q                 SC      F+ S + + ++
Sbjct: 846  -SGTPPRQGSITSPQANEQSVTPQ---------------RRSC------FESSPDPELKS 883

Query: 587  KGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQE 646
            + T        SS   ++   P   + S         RSS  +   P   +  S   +  
Sbjct: 884  R-TPSRHSCSGSSPPRVKSSTPPRQSPS---------RSSSPQ---PKVKAIISPRQRSH 930

Query: 647  PGGSHGSETEDTGRSLPSKKER----SGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKA 702
             G S  S +  T R+ P +       S    R   +  H  SS    K K +T  + S +
Sbjct: 931  SGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHS 990

Query: 703  ESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAE 762
             S     K K              ++  P P   GS SP P  + +    DS  +S P  
Sbjct: 991  GSISPYPKVK--------------AQTPPGPSLSGSKSPCPQEKSK----DSLVQSCP-- 1030

Query: 763  EGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDD 822
                G      G  SS   G    +     SS Q +  ++ S    HRS  SS +     
Sbjct: 1031 ----GSLSLCAGVKSSTPPG----ESYFGVSSLQLKGQSQTS--PDHRSDTSSPE----- 1075

Query: 823  ASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSS----SDASS 878
                + H +SPS  S+ +     G   S S        S  R  R  +S+S    S  S 
Sbjct: 1076 --VRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSP 1133

Query: 879  DQSCY-SRQRSYSDDSYSDYSDRSRRHSKRSHDS----DDSDYASSKHRSKRHKYSSSDD 933
            +QS + S   SY     +    +SR  +  S +        D  +S  R K        D
Sbjct: 1134 EQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQK--------D 1185

Query: 934  DYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRS--TTAHSWQRSRSYSRD 991
             +S    Q R  S    ++  R+  R RS + S   +K ++ +  T++   +      + 
Sbjct: 1186 KFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKS 1245

Query: 992  RSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQS---------PHYFRSG 1042
               + +  S  S   K               R  +   + +SQS         P    S 
Sbjct: 1246 EEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSW 1305

Query: 1043 RGE--GPGKKDDGRGD-DSKATGPPSQNSNIG-TGRGSEGDCSPEDKNSVTAKLLLEKIQ 1098
             G    P  K+         + G P +  N G  G       S E K  +    L     
Sbjct: 1306 GGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFL----- 1360

Query: 1099 SRKVERKPSVSEEVQATPNKAGPKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPN 1158
              ++E  PS+  + Q+T +      +  P      K   S       P++  +P T    
Sbjct: 1361 -NQLETDPSLDMKEQSTRSSGHSSSELSPDAV--EKAGMSSNQSISSPVLDAVPRTPSRE 1417

Query: 1159 KKCEESGLERGEEQEQSETEEGPPGSSDAL-FGHQFPSEET---TGPLLDPPPEESKSGE 1214
            +    S  E  +   ++ +     GSS  L  G   PS  +   + P +   P     G 
Sbjct: 1418 RSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGR 1477

Query: 1215 ATAD---HPVAPLGTPAHSDCYPGDPTISHNYL-PDPSDGDTLESLDSS--SQPGPVESS 1268
            +  D    P A   TP      P  P +++  L P      +  S+D    ++    + S
Sbjct: 1478 SECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRS 1537

Query: 1269 LLPIAPDLEHFPSYAPPSGDPSIESTDGAEDASLAPLESQPITFTPEEMEKYSKLQQAAQ 1328
                + +L+  PS +P     S  S D ++  +  PL  +  + +  E++  S+L     
Sbjct: 1538 RSGSSQELDVKPSASPQERSESDSSPD-SKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRS 1596

Query: 1329 QHIQQQLLAKQVKAFPASAALAPATP 1354
            +      +  + +A P + + + ++P
Sbjct: 1597 RSGSSPEVKDKPRAAPRAQSGSDSSP 1622



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 59/274 (21%), Positives = 87/274 (31%), Gaps = 55/274 (20%)

Query: 628  GRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKH 687
            G +  PA G   S +   EP  S G++      +L   KER                   
Sbjct: 2492 GMLSVPAPGVPHSDVG--EPPASTGAQQPSALAALQPAKER------------------- 2530

Query: 688  KRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADS----------ERGPKPEPPG 737
                ++ +   SS + S   S          + SS    S          +R P P P  
Sbjct: 2531 ----RSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAP 2586

Query: 738  SGS--------PAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGE 789
              +        P P +R+RR+   S   S  +   SS         SSS           
Sbjct: 2587 KEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2646

Query: 790  LPPSSCQ-------RRAGTKRSSRSSHRS----QPSSGDEDSDDASSHRLHQKSPSQYSE 838
              PS  +       + A  K+      RS    +P     DS   S   + ++ PS    
Sbjct: 2647 SSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPS 2706

Query: 839  EEEEEDSGSEH-SRSRSRSGRRHSSHRSSRRSYS 871
              +++ S SE  SR   R   R  SH+  R + S
Sbjct: 2707 PRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPS 2740



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 55/258 (21%), Positives = 97/258 (37%), Gaps = 36/258 (13%)

Query: 459  SEVSEQPKETSMTEPS-----EPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSS 513
            S+V E P  T   +PS     +P  +  +  +     S  S  S S   S +    S+ S
Sbjct: 2504 SDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDS 2563

Query: 514  KETSL-------------ATPAGKES-QEG-PKHPTGPFFPVLSKDESTALQWPSELLIF 558
            + +SL              TPA KE+ +EG P  PT    P   K  S++    S     
Sbjct: 2564 EGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPT----PAKRKRRSSSSSSSSSSSSS 2619

Query: 559  TKAEPSISYSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVG 618
            + +  S S S +        S +  + +  +       S +K   Q L P   +  K   
Sbjct: 2620 SSSSSSSSSSSS--------SSSSSSSSSSSSSSSSSPSPAKPGPQAL-PKPASPKKPPP 2670

Query: 619  GEKIVRSSGGRMDA--PASGSACSGLNKQEPGGSHGSETEDTGRS-LPSKKERSGKSHRH 675
            GE+  RS    +D+   +   + S + ++ P        + +  S   S++ + G S   
Sbjct: 2671 GERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSP 2730

Query: 676  KKKKKHKKSSKHKRKHKA 693
              K++ +  S    +H++
Sbjct: 2731 SHKRRRETPSPRPMRHRS 2748



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 37/152 (24%), Positives = 57/152 (37%), Gaps = 15/152 (9%)

Query: 417  SEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSEP 476
            S   D + ++ P   PE      P P    K A  +G          +P E +  +    
Sbjct: 2558 SSSSDSEGSSLPVQ-PEVALKRVPSPTPAPKEAVREG----------RPPEPTPAKRKRR 2606

Query: 477  GSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQEGPKHPTGP 536
             S + +  +     S  S  S S   S +    S+SS  +S  +PA    Q  PK P  P
Sbjct: 2607 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPK-PASP 2665

Query: 537  FFPVLSKDESTALQWPSELLIFTKAEPSISYS 568
              P   +  S + + P + L   +   S+SYS
Sbjct: 2666 KKPPPGERRSRSPRKPIDSL---RDSRSLSYS 2694



 Score = 32.3 bits (72), Expect = 3.5
 Identities = 47/221 (21%), Positives = 73/221 (33%), Gaps = 21/221 (9%)

Query: 961  RSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHS 1020
            RSSS S S S   S S+++ S   S   S   S  +  P Q   + KR     +P  + +
Sbjct: 2531 RSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRV-PSPTPAPKEA 2589

Query: 1021 GRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDC 1080
             R         R   P   +  R              S ++   S +S+  +   S    
Sbjct: 2590 VREG-------RPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2642

Query: 1081 SPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPNKAGPKLKDPPQGYFGPKLPPSLG 1140
            S    +   AK   + +      +KP   E    +P K    L+D            SL 
Sbjct: 2643 SSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRD----------SRSLS 2692

Query: 1141 NKPVLPLIGKLPATRKPNKKCEESGLERGEEQEQSETEEGP 1181
              PV     + P+ +   +  + S  ERG  + Q      P
Sbjct: 2693 YSPV---ERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSP 2730


>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
          Length = 754

 Score =  109 bits (272), Expect = 2e-23
 Identities = 142/630 (22%), Positives = 244/630 (38%), Gaps = 97/630 (15%)

Query: 553  SELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPN 612
            S+  I TK  P +    + + F   +S  +  R    +K  D  S     ++ L  GE  
Sbjct: 122  SQFFITTKPTPHLDG--HHVVFGQVISGQEVVREIENQKT-DAASKPFAEVRILSCGELI 178

Query: 613  KSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKS 672
               +V  E+  R       + +S  + S  + Q    S  SE+    +S   KK+    S
Sbjct: 179  PKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNS 238

Query: 673  HRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEK----------------------SKK 710
             +HKK+KK +K SK     +++ E   ++ +S  +                       K+
Sbjct: 239  RKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKE 298

Query: 711  RKKRKRKKNKSSAPADSE-------------------RGPKPEPPGS---------GSPA 742
            RK R+R++ +   P +S+                   RGP+     S          S  
Sbjct: 299  RKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSET 358

Query: 743  PPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPP----SSCQRR 798
            PP  R+  Q   + R    E    G K E      +Q    R  + ++      S    R
Sbjct: 359  PPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNR 418

Query: 799  AGTKRSSRSSHRSQPSSGD----EDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRS 854
               K      H+S     D     + DD   +++ +++ S+   + +E+    E     +
Sbjct: 419  KNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHN 478

Query: 855  RSGRRHSSHRSSRRSYSS--SSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSD 912
            R+  +    RS  R + +    +  SD     ++RS S +       +S  H        
Sbjct: 479  RNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEH-------- 530

Query: 913  DSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKR 972
              D++ SK + +R +  S + D     ++ +    S TRERSRSR RSR    SR+  + 
Sbjct: 531  --DHSKSKEKDRRAQSRSRECD----ITKGKHSYNSRTRERSRSRDRSRRVR-SRTHDRD 583

Query: 973  RSRSTTAHSW--QRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKI 1030
            RSRS   H +  Q  R   R RSR  R+P  RS S+          +R   RRD   S+ 
Sbjct: 584  RSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSK----------DRRRRRRDSRSSER 633

Query: 1031 YRSQSPH--YFRSGRGEGPGKKDDGRGDDSKATGPPSQN-SNIGTGRGSEGDCSPEDK-- 1085
              SQS +   +R+   +   +K++   +    +     N SN    + ++ D SP  K  
Sbjct: 634  EESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIK 693

Query: 1086 -NSVTAKLLLEKIQSRKVER-KPSVSEEVQ 1113
             +S   +L    +++++ E+ + SV +E Q
Sbjct: 694  QSSQDNELKSSMLKNKEDEKIRSSVEKENQ 723



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 96/411 (23%), Positives = 166/411 (40%), Gaps = 74/411 (18%)

Query: 653  SETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKR--KHKADTEEKSSKAESGEKSKK 710
            +E ++  RS    KER    HR+  +  ++K+ K K+   HK++++E+  +  S EK  K
Sbjct: 389  NEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNS-EKDDK 447

Query: 711  RKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKD 770
             K + +K+ KS + + S+   K +   S       +R R++                   
Sbjct: 448  YKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSR------------------- 488

Query: 771  EGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRS-QPSSGDEDSDDASSHRLH 829
                 S  +DH   K K +   S    +   +  SRS  +S Q  S   + D + S    
Sbjct: 489  -----SKGRDHENVKEKEKQSDS----KGKDQERSRSKEKSKQLESKSNEHDHSKSKEKD 539

Query: 830  QKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSY 889
            +++ S+  E +  +   S +SR+R RS    S  RS R                 R R++
Sbjct: 540  RRAQSRSRECDITKGKHSYNSRTRERS---RSRDRSRR----------------VRSRTH 580

Query: 890  SDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSH 949
                     DR R  SK  H   + +Y        R + +             RSRS+  
Sbjct: 581  ---------DRDRSRSKEYHRYREQEYRRRGRSRSRERRT----------PPGRSRSKDR 621

Query: 950  TRERSRSRGRSRSSSCSRSRSK-RRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKR 1008
             R R  SR   R  S SR++ K R   S ++H  + S S  R  S+S    S  +   K+
Sbjct: 622  RRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKK 681

Query: 1009 SWGHESP--EERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDD 1057
            +   +SP  + + S + + ++S + +++     RS   E   +K  G+ +D
Sbjct: 682  ADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSS-VEKENQKSKGQEND 731



 Score = 35.0 bits (79), Expect = 0.55
 Identities = 55/290 (18%), Positives = 104/290 (35%), Gaps = 33/290 (11%)

Query: 447 KAAASQGAEKTVSEVSEQPKETSMTEPSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQ 506
           K A S+   K+  +   + +++      E   ++ +K     +V ++  +S S+   +  
Sbjct: 454 KRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQ-- 511

Query: 507 MCESNSSKETSLATPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSIS 566
             E + SKE S    +     +  K          SK++    Q  S     TK +    
Sbjct: 512 --ERSRSKEKSKQLESKSNEHDHSK----------SKEKDRRAQSRSRECDITKGK---- 555

Query: 567 YSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHL--------QGLDPGE-----PNK 613
           +S N    +   SR++  R +     +D   S + H         +G          P +
Sbjct: 556 HSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGR 615

Query: 614 SKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSH 673
           S+     +  R S       +          QE   SH  E  ++ + + SK      S+
Sbjct: 616 SRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSN 675

Query: 674 RHKKKKKHKKSSKHK--RKHKADTEEKSSKAESGEKSKKRKKRKRKKNKS 721
             ++KK  +  S     ++   D E KSS  ++ E  K R   +++  KS
Sbjct: 676 NSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKS 725



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 29/133 (21%), Positives = 54/133 (40%), Gaps = 12/133 (9%)

Query: 1058 SKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPN 1117
            S ++   S + +  +   S+ + + E+K+    K   +  +  K E+K     +  A+  
Sbjct: 199  SSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSE 258

Query: 1118 KAGPKLKDPPQGYFGP-KLPPSLGNKPVLPLIGKLPATRKPNKKCEESGLERGEEQEQSE 1176
                 L+  PQ    P ++PP   N+ ++         RK   K +E   ER   + + E
Sbjct: 259  SEAENLEAQPQSTVRPEEIPPIPENRFLM---------RKSPPKADEK--ERKNRERERE 307

Query: 1177 TEEGPPGSSDALF 1189
             E  PP S  A +
Sbjct: 308  RECNPPNSQPASY 320


>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
          Length = 494

 Score =  107 bits (267), Expect = 9e-23
 Identities = 96/341 (28%), Positives = 156/341 (45%), Gaps = 28/341 (8%)

Query: 655 TEDTGRSLPSKKERSGKSHR--HKKKKKHKKS---SKHKRKHKADT-EEKSSKAESGEKS 708
           TE  GR +   +++ G   R  + + + H +S   S+H RK ++ +   KSS ++S  +S
Sbjct: 163 TEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRS 222

Query: 709 K-----KRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEE 763
           +     + K R R +++S +  +  R P  E   S S +  + R +++D ++ +      
Sbjct: 223 RSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKI----- 277

Query: 764 GSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGT-KRSSRSSHRSQPSSGDED--- 819
               + ++  G   S+     K K +    S +RR    KR S S  RSQ  S  +    
Sbjct: 278 ----QNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSR 333

Query: 820 --SDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDAS 877
             S   S  R   +S S+   +  +       SRSRSRS    S  R S+R   + S   
Sbjct: 334 SRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKK 393

Query: 878 SDQSCYSRQRSYSDD-SYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYS 936
             +    R +S S   S S   + ++  S +     +S+ A +   ++    S+S    +
Sbjct: 394 KKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPN 453

Query: 937 L-SCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRS 976
           L S S+SRS+S S TR RS+SR RS S S SRSRS+  SRS
Sbjct: 454 LPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSRS 494



 Score =  100 bits (249), Expect = 1e-20
 Identities = 104/351 (29%), Positives = 142/351 (40%), Gaps = 59/351 (16%)

Query: 624 RSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLP-----SKKERSGKSHRHKKK 678
           RS   R     SGS+ S  +K       GS +    RS       SKKE+S    + K +
Sbjct: 197 RSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSR 256

Query: 679 KKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGS 738
            +   + K + K K   EEK    ++  K K R   + K    S     ER  + E  GS
Sbjct: 257 SRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGS 316

Query: 739 GSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRR 798
            S      R R+Q+ S R+S                 S S+  GG + +      S  +R
Sbjct: 317 VS------RGRSQEKSLRQS----------------RSRSRSKGGSRSRSRSRSKSKDKR 354

Query: 799 AGTKRSSRSSH-RSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSG 857
            G KRS   S  RS+  S  E S    S R    S +  S+++++ED+    SRS SRS 
Sbjct: 355 KGRKRSREESRSRSRSRSKSERSRKRGSKR---DSKAGSSKKKKKEDTDRSQSRSPSRSV 411

Query: 858 RRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYA 917
            +   H  S  S       S +       RS           RSR +SK    S  +  +
Sbjct: 412 SKEREHAKSESSQREGRGESENAGTNQETRS-----------RSRSNSK----SKPNLPS 456

Query: 918 SSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRS 968
            S+ RSK             S S++RSRS+S +R  SRS  RSRS S SRS
Sbjct: 457 ESRSRSK-------------SASKTRSRSKSRSRSASRSPSRSRSRSHSRS 494



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 86/290 (29%), Positives = 124/290 (42%), Gaps = 18/290 (6%)

Query: 743  PPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTK 802
            P  RRRR+   S+  S         +K     GSS   H   + +     S  + R+ ++
Sbjct: 177  PGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSR---SGSRSRSKSR 233

Query: 803  RSSRSSHRSQPSSGDEDSDDASSHRLHQ--KSPSQYSEEEEEEDSGSEH-SRSRSRSGRR 859
              S+S  RS+       S + S  R H   KS S+  ++ EE+   +++  + +SRS  R
Sbjct: 234  SRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSR 293

Query: 860  HSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASS 919
            H S   SR            +   SR RS      S    RSR  SK    S     + S
Sbjct: 294  HKSKSKSRSRSQERRVEEEKRGSVSRGRS---QEKSLRQSRSRSRSKGGSRSRSRSRSKS 350

Query: 920  KHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTA 979
            K + K  K S  +       S+SRSRSRS + ERSR RG  R S    S+ K++  +  +
Sbjct: 351  KDKRKGRKRSREE-------SRSRSRSRSKS-ERSRKRGSKRDSKAGSSKKKKKEDTDRS 402

Query: 980  HSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSK 1029
             S   SRS S++R  +    SQR G R  S    + +E  S  R   +SK
Sbjct: 403  QSRSPSRSVSKEREHAKSESSQREG-RGESENAGTNQETRSRSRSNSKSK 451



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 117/387 (30%), Positives = 165/387 (42%), Gaps = 74/387 (19%)

Query: 771  EGGGGSSSQDHGGRKHKG--ELPPSSCQRRA-----GTKRSSRSSHRSQPSSGDEDSDDA 823
            + G  + +  H GRK++G  E    S  +RA     GT+ + R     +   G       
Sbjct: 126  QAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSY 185

Query: 824  SSHRLHQKSPSQYSEEEEEEDSGSEHSR-SRSRSGRRHSSHRSSR-RSYSSSSDASSDQS 881
            S  R H +S S+           S HSR SRSRSG   SSH  SR RS S S   S  +S
Sbjct: 186  SRSRSHSRSRSR-----------SRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRS 234

Query: 882  -CYSRQRSYSDDSYSDYSD--RSRRHSKRSHDSDDSDYAS-----------------SKH 921
               SR RS  + S S   +  RSR HS     S   D A                  S+H
Sbjct: 235  RSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRH 294

Query: 922  RSKRHKYSSS-----DDDYSLSCSQSRS--------RSRSHTRERSRSRGRSRSSSCSRS 968
            +SK    S S     +++   S S+ RS        RSRS ++  SRSR RSRS S  + 
Sbjct: 295  KSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKR 354

Query: 969  RSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRS 1028
            + ++RSR       + SRS SR RS+S R  S++ GS++ S    S +++   + D  RS
Sbjct: 355  KGRKRSR-------EESRSRSRSRSKSER--SRKRGSKRDSKAGSSKKKK---KEDTDRS 402

Query: 1029 KIYRSQSPHYFRSGRGE---GPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDK 1085
               +S+SP    S   E       + +GRG+   A       S   +   S+ +   E +
Sbjct: 403  ---QSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESR 459

Query: 1086 N---SVTAKLLLEKIQSRKVERKPSVS 1109
            +   S +      K +SR   R PS S
Sbjct: 460  SRSKSASKTRSRSKSRSRSASRSPSRS 486



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 68/263 (25%), Positives = 107/263 (40%), Gaps = 26/263 (9%)

Query: 579 SRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKI----------VRSSGG 628
           SR+K  +++   K K   S S+ H  G      +KSK+   EKI           RS   
Sbjct: 240 SRSKKEKSRSPSKEK---SRSRSHSAGKSR---SKSKDQAEEKIQNNDNVGKPKSRSPSR 293

Query: 629 RMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHK 688
                 S S       +E      S      +SL   + RS      + + + +  SK K
Sbjct: 294 HKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDK 353

Query: 689 RKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPR--- 745
           RK +  + E+ S++ S  +SK  + RKR   + S    S++  K +   S S +P R   
Sbjct: 354 RKGRKRSREE-SRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVS 412

Query: 746 -RRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQR-RAGTKR 803
             R  A+ +S +R    E  ++G   E    + S+     K K  LP  S  R ++ +K 
Sbjct: 413 KEREHAKSESSQREGRGESENAGTNQE----TRSRSRSNSKSKPNLPSESRSRSKSASKT 468

Query: 804 SSRSSHRSQPSSGDEDSDDASSH 826
            SRS  RS+ +S       + SH
Sbjct: 469 RSRSKSRSRSASRSPSRSRSRSH 491


>gi|50083281 KIAA1853 protein [Homo sapiens]
          Length = 611

 Score =  103 bits (257), Expect = 1e-21
 Identities = 147/535 (27%), Positives = 201/535 (37%), Gaps = 135/535 (25%)

Query: 579  SRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSA 638
            SR K  + K T K +   SS         P    K K+   +K  R              
Sbjct: 106  SRGKKKKKKSTRKKRRRSSS-------YSPSPVKKKKKKSSKKHKRRRS----------- 147

Query: 639  CSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKS-SKHKRKHKADTEE 697
                 ++    S  S+  D  R     + R  KSHRH+  +   +S S   R    ++  
Sbjct: 148  -FSKKRRHSSSSPKSKRRDEKRHKKQSRSRPRKSHRHRHHRCPSRSQSSESRPSSCESRH 206

Query: 698  KSSKAESGEKSKKRKKRKRKKN--KSSAPADSERGPKPEP-------------PGSGSPA 742
            +    E G+KS++R  R+  K   K S  A S R P  +P              GSGS A
Sbjct: 207  RGRSPEEGQKSRRRHSRRCSKTLCKDSPEAQSSRPPS-QPLQMLGYLSARGVITGSGSAA 265

Query: 743  P---------PRRRRRAQD--------------DSQRRSLPAEEGS------------SG 767
                         R R+Q+               S  RS   E+GS            SG
Sbjct: 266  DLFTKTASPLTTSRGRSQEYDSGNDTSSPPSTQTSSARSRGQEKGSPSGGLSKSRELNSG 325

Query: 768  KKDEGGGG---SSSQDHG-----------GRKHKGELPPSSCQRRAGTKRSSR--SSHRS 811
               + G     SS Q+ G           GR+ +G   P  C   A  K+SS   S+ RS
Sbjct: 326  NTSDSGNSFTTSSPQNKGAMLENLSPTSRGRESRGFQSP--CLECAEVKKSSLVPSTARS 383

Query: 812  QPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYS 871
             P  G   S   +S R      S +S       +   +++SRS S  + S  RS   SYS
Sbjct: 384  SPMKGCSRSSSYASTR-----SSSHSSRSPNPRASPRYTQSRSTSSEKRSYSRSP--SYS 436

Query: 872  SSSDASSDQSCYSR-QRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRS-----KR 925
            S S   S  S  SR +RS S   YS   +R  ++S++     + + A  + RS     KR
Sbjct: 437  SKSGKRSPPSRSSRSRRSPSYSRYSPSRERDPKYSEKDSQQRERERARRRRRSYSPMRKR 496

Query: 926  HK-------------------------------YSSSDDDYSLSCSQSRSRSRSHTRERS 954
             +                                SS+   YS S S+S SRS S +R RS
Sbjct: 497  RRDSPSHLEARRITSARKRPIPYYRPSPSSSGSLSSTSSWYSSSSSRSASRSYSRSRSRS 556

Query: 955  RSRGRS--RSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRK 1007
            RSR RS  R+SS S SRS      + + S  RSRS SR +SRS  S    S +R+
Sbjct: 557  RSRRRSRTRTSSSSSSRSPSPGSRSRSRSRSRSRSRSRSQSRSYSSADSYSSTRR 611



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 112/442 (25%), Positives = 170/442 (38%), Gaps = 50/442 (11%)

Query: 646  EPGGSHGSETEDTGRSLPSKKERSGK----------SHRHKKKKKHKKSSKHKRKHKADT 695
            EP G++  E + T R L + +  S            S   KKKKK  +  + +    + +
Sbjct: 70   EPLGTNSWERDKTCRELGATRGHSASHDKDLTPPPSSRGKKKKKKSTRKKRRRSSSYSPS 129

Query: 696  EEKSSKAESGEKSKKRKK-RKRKKNKSSAPADSERGPKPEPPGSGS-PAPPRRRRRAQDD 753
              K  K +S +K K+R+   K++++ SS+P    R  K     S S P    R R  +  
Sbjct: 130  PVKKKKKKSSKKHKRRRSFSKKRRHSSSSPKSKRRDEKRHKKQSRSRPRKSHRHRHHRCP 189

Query: 754  SQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQP 813
            S+ +S  +   S   +  G      Q    R+H      + C+    +  +  S   SQP
Sbjct: 190  SRSQSSESRPSSCESRHRGRSPEEGQ-KSRRRHSRRCSKTLCK---DSPEAQSSRPPSQP 245

Query: 814  -------SSGDEDSDDASSHRLHQKSPSQYSE---EEEEEDSGSEHS----------RSR 853
                   S+    +   S+  L  K+ S  +      +E DSG++ S          RSR
Sbjct: 246  LQMLGYLSARGVITGSGSAADLFTKTASPLTTSRGRSQEYDSGNDTSSPPSTQTSSARSR 305

Query: 854  SRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDS-- 911
             +     S   S  R  +S + + S  S  +           + S  SR    R   S  
Sbjct: 306  GQEKGSPSGGLSKSRELNSGNTSDSGNSFTTSSPQNKGAMLENLSPTSRGRESRGFQSPC 365

Query: 912  ------DDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSC 965
                    S    S  RS   K  S    Y+ + S S S SRS     S    +SRS+S 
Sbjct: 366  LECAEVKKSSLVPSTARSSPMKGCSRSSSYASTRSSSHS-SRSPNPRASPRYTQSRSTS- 423

Query: 966  SRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDF 1025
            S  RS  RS S ++ S +RS      RSR + S S+ S SR+R   +   + +   R   
Sbjct: 424  SEKRSYSRSPSYSSKSGKRSPPSRSSRSRRSPSYSRYSPSRERDPKYSEKDSQQRERERA 483

Query: 1026 IRSKIYRSQSPHYFRSGRGEGP 1047
             R +  RS SP   R  R + P
Sbjct: 484  RRRR--RSYSP--MRKRRRDSP 501



 Score = 40.0 bits (92), Expect = 0.017
 Identities = 49/195 (25%), Positives = 80/195 (41%), Gaps = 35/195 (17%)

Query: 923  SKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSR-SKRRSRSTTAHS 981
            ++ H  S   D      S+ + + +  TR++     R RSSS S S   K++ +S+  H 
Sbjct: 89   TRGHSASHDKDLTPPPSSRGKKKKKKSTRKK-----RRRSSSYSPSPVKKKKKKSSKKH- 142

Query: 982  WQRSRSYSRDRSRSTRSP--SQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQS-PHY 1038
             +R RS+S+ R  S+ SP   +R   R +      P + H  R     S+   S+S P  
Sbjct: 143  -KRRRSFSKKRRHSSSSPKSKRRDEKRHKKQSRSRPRKSHRHRHHRCPSRSQSSESRPSS 201

Query: 1039 FRS---GRGEGPGKKDDGR------------GDDSKATGPPSQ---------NSNIGTGR 1074
              S   GR    G+K   R              +++++ PPSQ            + TG 
Sbjct: 202  CESRHRGRSPEEGQKSRRRHSRRCSKTLCKDSPEAQSSRPPSQPLQMLGYLSARGVITGS 261

Query: 1075 GSEGDCSPEDKNSVT 1089
            GS  D   +  + +T
Sbjct: 262  GSAADLFTKTASPLT 276


>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
          Length = 715

 Score =  100 bits (248), Expect = 1e-20
 Identities = 158/722 (21%), Positives = 254/722 (35%), Gaps = 95/722 (13%)

Query: 429  KNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSEPGSKAEAKKALGG 488
            K+A  ++     KP +   +  S  + K+    S   K      PS   S+  +K     
Sbjct: 36   KSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTST--KRAPSNRPSSR-SRVRSKARTPS 92

Query: 489  DVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQEGPKHPTGPFFPVLSKDESTA 548
             VS  +  S + K S+ + C       +   TP  + S+   + P+    P   +     
Sbjct: 93   RVSTDTRTSKASKASDVR-CHQRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGAR 151

Query: 549  LQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDP 608
                S +   T                   S+ K +R K   +P+   +S+++       
Sbjct: 152  PGMASRVRTPT-------------------SQQKGSRGKSYGRPR---TSNRERSDSQPR 189

Query: 609  GEPNKS-KEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKE 667
                KS +  GG  I RSS   +    S + C     Q P G    E  D      S+K 
Sbjct: 190  NLSKKSYRPPGGSGIGRSS--ELAVTPSTAKC-----QTPTGIPSKEKSDNPSPSSSRKV 242

Query: 668  RSGKS----HRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSA 723
            +S        R K     + SS+ K  ++A T  +          ++ +   +K+  S  
Sbjct: 243  KSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRV 302

Query: 724  PADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHG- 782
             + S +               R   RA+  +++  L      S  +    G S +Q    
Sbjct: 303  RSHSWK---------------RNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTP 347

Query: 783  --GRKHKGELPPS-----SCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQ 835
              GR H     PS     S  R +  +R  R S   +  SG   S   +  R H +S S 
Sbjct: 348  RRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSP 407

Query: 836  YSEEEEEEDSGSEHSRSRSRS---------GRRHSSHRSSRRSYSSSSDASSDQSCYSRQ 886
                +         +R RSRS          R  S +++  RS S S + + D S     
Sbjct: 408  NKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSP 467

Query: 887  RSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRH-----KYSSSDDDYSLSCSQ 941
                D S S    + R HS+    S + D+  S+  SK       + SS + D+  S S 
Sbjct: 468  NKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSP 527

Query: 942  SRSRSRSHTRE--RSRSRGRSRSSSCSRS--RSKRRSRSTTAHSWQRSRSYSRDRSRSTR 997
            S+ R R  +R   + R R +SRS S  R   +S+  S+      W RS S  R+R +S  
Sbjct: 528  SKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRW-RSPSKERERRQSRS 586

Query: 998  SPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDD 1057
            S  +R  SR RS   +S          + R +    +  H     R   P K  +G    
Sbjct: 587  SSEERDHSRSRSPNKQS---------GYSRPRASSKEKAH----SRSRTPSK--EGNHSQ 631

Query: 1058 SKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPN 1117
            S+ +   S  S     R  +   SP   +S++      K  S      PS  + +    +
Sbjct: 632  SRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDS 691

Query: 1118 KA 1119
            +A
Sbjct: 692  QA 693



 Score = 94.7 bits (234), Expect = 6e-19
 Identities = 175/730 (23%), Positives = 276/730 (37%), Gaps = 117/730 (16%)

Query: 624  RSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSL-PSKKERSGKSHRHKKKKKHK 682
            RSS   M    SGS+    + + P     +++    RSL P+K   S  S       K  
Sbjct: 6    RSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSSKST 65

Query: 683  KSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPAD----SERGPKPE---P 735
            KS+  KR   ++     S+  S  ++  R     + +K+S  +D      RG       P
Sbjct: 66   KSTSTKRA-PSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTP 124

Query: 736  PGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGK------KDEGGGGSS-SQDHGGRKHKG 788
               GS +  R   RA    + R+  A  G + +      + +G  G S  +     + + 
Sbjct: 125  GRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERS 184

Query: 789  ELPPSSCQRR-------AGTKRSSR-----SSHRSQ-----PSSGDEDSDDASSHRLHQK 831
            +  P +  ++       +G  RSS      S+ + Q     PS    D+   SS R  + 
Sbjct: 185  DSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKS 244

Query: 832  -------------SPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASS 878
                         SP++ S   +  +  S  SR +S     HS  RS RRS S      S
Sbjct: 245  YGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQS-----HSQSRSPRRSRS-----GS 294

Query: 879  DQSCYSRQRSYS-DDSYSDYSDRSR--------RHSK-RSHDSDDSDYAS-SKHRSKRHK 927
             +  +SR RS+S   ++S    R+R        RHS+ RSH    S   S +  R + H 
Sbjct: 295  QKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHN 354

Query: 928  YS---SSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRS-TTAHSWQ 983
            +S   S +  +S S S S+ R    +    +  GRS+S S ++ R   RSRS   A    
Sbjct: 355  WSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRS 414

Query: 984  RSRS--YSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRS 1041
            RSRS   +RDRSRS      R  SR RS       +R   R         RS+SP+  R 
Sbjct: 415  RSRSPYKARDRSRSRSPNKARDCSRSRS--PYKARDRSRSRSPNKARDHSRSRSPNKARD 472

Query: 1042 -GRGEGPGKKDD-------GRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLL 1093
              R   P K+ D        +  D + +  PS+       R S  +       S + +  
Sbjct: 473  RSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQ 532

Query: 1094 LEKIQSRKVER----KPSVSEEVQATPNKAGPKLKDPPQGYFGPKLPPSLGNKPVLPLIG 1149
              + +S   ER      S SEE +   +++  K +D  +                     
Sbjct: 533  RRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRR--------------------W 572

Query: 1150 KLPATRKPNKKCEESGLERGEEQEQSETEE---GPPGSSDALFGH---QFPSEETTGPLL 1203
            + P+  +  ++   S  ER   + +S  ++     P +S     H   + PS+E      
Sbjct: 573  RSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQS 632

Query: 1204 DPPPEESKSGEATA----DHPVAPLGTPAHSDCYPGDPTISHNYLPDPSDGDTLESLDSS 1259
                +ES   ++T     D   +P  T + S       T SH+    PS G TL   DS 
Sbjct: 633  RTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQ 692

Query: 1260 SQPGPVESSL 1269
            +     +++L
Sbjct: 693  ADATTSKATL 702



 Score = 35.8 bits (81), Expect = 0.32
 Identities = 41/196 (20%), Positives = 76/196 (38%), Gaps = 20/196 (10%)

Query: 579 SRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSA 638
           S +K+ + + +  P    +  +D  Q   P E  + ++       RS     D     S 
Sbjct: 526 SPSKERQRRQSRSP----NKERDRSQSRSPSEEREHRQS------RSPSKERDRRRWRSP 575

Query: 639 CSGLNKQEPGGSHGSETEDTGRSL-PSKKERSGKSHRHKKKKKHKKS-SKHKRKHKADTE 696
                +++   S  SE  D  RS  P+K+    +     K+K H +S +  K  + + + 
Sbjct: 576 SKERERRQSRSS--SEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSR 633

Query: 697 EKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQ- 755
             S +++  + +  R    ++    ++     R P      S S  P   +  +QDDSQ 
Sbjct: 634 TSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQA 693

Query: 756 -----RRSLPAEEGSS 766
                + +LP E  SS
Sbjct: 694 DATTSKATLPGERSSS 709


>gi|60097902 filaggrin [Homo sapiens]
          Length = 4061

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 175/758 (23%), Positives = 270/758 (35%), Gaps = 128/758 (16%)

Query: 417  SEQMDGD-NTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSE 475
            SE+  G  +  H  +A E  +  S  P+S  +  A  G     S  S +   T  T+ S 
Sbjct: 2580 SERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGH----SADSSRQSGTRHTQTSS 2635

Query: 476  PGSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQEGPKHPTG 535
             G  A + +       ++    H Q    ++       + +S    +G     G +    
Sbjct: 2636 GGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDN 2695

Query: 536  PFFPVLSKDESTALQWPSELLIFTKAEP----SISYSCNPLYFDFKLSRNKDARTK-GTE 590
                  S  +S +    +     +  E     S   S +   F +++S ++ + +  G  
Sbjct: 2696 EGHSEDSDTQSVSAHGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWT 2755

Query: 591  KPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVR-----SSGGRMDAPASGSACSGLNKQ 645
             P   G     H Q  D    + S++  G+  +R     S GGR       S  S  +  
Sbjct: 2756 GPSTRGRQGSRHEQAQDSSRHSASQD--GQDTIRGHPGSSRGGRQGYHHEHSVDSSGHS- 2812

Query: 646  EPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKS--SKHK--RKHKADTE---EK 698
               GSH S T   GRS  S+ +   +S     + + +    S+H   R H+A T     +
Sbjct: 2813 ---GSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDGSRHSGSRHHEASTHADISR 2869

Query: 699  SSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAP-------------PR 745
             S+A  G+    R+ R R+ +  S  +DSE   +     SGS +               R
Sbjct: 2870 HSQAVQGQSEGSRRSR-RQGSSVSQDSDSEGHSEDSERWSGSASRNHHGSAQEQLRDGSR 2928

Query: 746  RRRRAQDDSQRRSLPAEE----GSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGT 801
              R  Q+D       A+     G+   +   GG ++S     R   GE   S  Q+ A +
Sbjct: 2929 HPRSHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADS 2988

Query: 802  KRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEE-EEEDSGSEHSRSRSRSGRRH 860
             R S   H  Q SS   DS     HR +  S SQ S+ E   EDS ++   +  ++G   
Sbjct: 2989 SRHSGIGH-GQASSAVRDS----GHRGY--SGSQASDNEGHSEDSDTQSVSAHGQAGSHQ 3041

Query: 861  SSHRSSRRSYSSSSDASSDQSCY---SRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYA 917
             SH+ S R  S  +   S    Y   + ++S S   ++  S R R+ S+     D S ++
Sbjct: 3042 QSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQAQDSSRHS 3101

Query: 918  SSK------------------------------HRSKRHKYSSSDDDYSLSCSQSRSRSR 947
            +S+                              H    H +++S      S  QS SRS 
Sbjct: 3102 ASQYGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSA 3161

Query: 948  SHTRERSRSRGRSRSSSCSR--------------------SRSKRRSRSTTAHSWQRSRS 987
            S T       G S   S SR                    S   RRSR   +   Q S S
Sbjct: 3162 SRTTRNEEQSGDSSRHSVSRHHEASTHADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDS 3221

Query: 988  --YSRDRSRSTRSPSQ----------RSGSR--------KRSWGHESPEERHSGRRDFIR 1027
              +S D  R + S S+          R GSR        +   GH +   R SG R    
Sbjct: 3222 EGHSEDSERWSGSASRNHRGSVQEQSRHGSRHPRSHHEDRAGHGHSADRSRQSGTRHAET 3281

Query: 1028 SKIYRSQSPH-YFRSGRGEGPGKKDDGRGDDSKATGPP 1064
            S   ++ S H   RS  GE  G +     D S+ +G P
Sbjct: 3282 SSGGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIP 3319



 Score = 98.6 bits (244), Expect = 4e-20
 Identities = 167/739 (22%), Positives = 262/739 (35%), Gaps = 95/739 (12%)

Query: 417  SEQMDGD-NTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSE 475
            SE+  G  +  H  +A E  +  S  P+S  +  A  G     S  S  P   + +    
Sbjct: 959  SERWSGSASRNHRGSAQEQSRHGSRHPRSHHEDRAGHGHSADSSRQSGTPHAETSSGGQA 1018

Query: 476  PGSKAEAKKALG---GDVSDQSLESHSQKVSETQMCES---------NSSKETSLATPAG 523
              S  +A+ + G   G    QS +S        +   S         +S  + S +    
Sbjct: 1019 ASSHEQARSSPGERHGSRHQQSADSSRHSGIPRRQASSAVRDSGHWGSSGSQASDSEGHS 1078

Query: 524  KESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKD 583
            +ES        G   P     + +A  W            S   S     F +++S ++ 
Sbjct: 1079 EESDTQSVSGHGQDGPHQQSHQESARDW------------SGGRSGRSGSFIYQVSTHEQ 1126

Query: 584  ARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLN 643
            + +         G     H +       + + + G + I    G R            ++
Sbjct: 1127 SESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRAHPGSRRGGRQGSHHEQSVD 1186

Query: 644  KQEPGGSHGSETEDTGRSLPSKKERSGKS--HRHKKKKKHKKSSKHK--RKHKADTEEKS 699
            +    GSH S T   GRS  S  +   +S   + +K K+    S+H   R H+A +   S
Sbjct: 1187 RSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRKDKQSGDGSRHSGSRHHEAASWADS 1246

Query: 700  SK-AESGEKSKKRKKRKRKKNKS-SAPADSERGPKPEPPGSGSPAPPRR---RRRAQDDS 754
            S+ ++ G++     +  R +  S S  +DSER        SGS +       R +++D S
Sbjct: 1247 SRHSQVGQEQSSGSRTSRHQGSSVSQDSDSERHSDDSERLSGSASRNHHGSSREQSRDGS 1306

Query: 755  QRRSLPAEEGSS------GKKDEGGGGSSSQDHG--------GRKHKGELPPSSCQRRAG 800
            +      E+ +S        +  G   + S  HG         R   GE   S  Q+ A 
Sbjct: 1307 RHPGFHQEDRASHGHSADSSRQSGTHHTESSSHGQAVSSHEQARSSPGERHGSRHQQSAD 1366

Query: 801  TKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEE-EEEDSGSEHSRSRSRSGRR 859
            + R S   HR Q SS   DS    S      S SQ +  E   EDS ++   +  ++G  
Sbjct: 1367 SSRHSGIGHR-QASSAVRDSGHRGS------SGSQVTNSEGHSEDSDTQSVSAHGQAGPH 1419

Query: 860  HSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASS 919
              SH+ S R  S  S   S    Y  Q S  + S S +   +     R     +    SS
Sbjct: 1420 QQSHKESARGQSGESSGRSRSFLY--QVSSHEQSESTHGQTAPSTGGRQGSRHEQARNSS 1477

Query: 920  KHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTA 979
            +H +      S D   ++      SR         +S  RS  S    S +  + RS  +
Sbjct: 1478 RHSA------SQDGQDTIRGHPGSSRGGRQGSYHEQSVDRSGHSGYHHSHTTPQGRSDAS 1531

Query: 980  HSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYF 1039
            H     +S  R  SR TR+  Q                RHSG R    S   R+ S  + 
Sbjct: 1532 HG----QSGPRSASRQTRNEEQSGDG-----------SRHSGSRHHEPST--RAGSSRHS 1574

Query: 1040 RSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAK---LLLEK 1096
            + G+GE  G K   R           Q S++   R SEG     ++ S +A        +
Sbjct: 1575 QVGQGESAGSKTSRR-----------QGSSVSQDRDSEGHSEDSERRSESASRNHYGSAR 1623

Query: 1097 IQSRKVERKPSVSEEVQAT 1115
             QSR   R P   +E +A+
Sbjct: 1624 EQSRHGSRNPRSHQEDRAS 1642



 Score = 95.1 bits (235), Expect = 4e-19
 Identities = 230/1054 (21%), Positives = 351/1054 (33%), Gaps = 163/1054 (15%)

Query: 452  QGAEKTVSEVSEQPKETSMTEP-SEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCES 510
            Q  + +    S++ ++T    P S  G +  +      D S  S   HS   S+ +   S
Sbjct: 1148 QARDSSRHSASQEGQDTIRAHPGSRRGGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDAS 1207

Query: 511  NS---SKETSLATPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISY 567
            +    S+  S  T   K+S +G +H               A  W          +   S 
Sbjct: 1208 HGQSGSRSASRQTRKDKQSGDGSRHS--------GSRHHEAASWADSSRHSQVGQEQSSG 1259

Query: 568  SCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSG 627
            S    +    +S++ D+     +  +  GS+S++H         + S+  G  +  R+S 
Sbjct: 1260 SRTSRHQGSSVSQDSDSERHSDDSERLSGSASRNHHGSSREQSRDGSRHPGFHQEDRASH 1319

Query: 628  GRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKH 687
            G     A  S  SG +  E   SHG       ++  S  ER G  H+            H
Sbjct: 1320 GHS---ADSSRQSGTHHTE-SSSHGQAVSSHEQARSSPGERHGSRHQQSADSSRHSGIGH 1375

Query: 688  KRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGP-----KPEPPGSGSPA 742
            ++   A   +   +  SG +    +      +  S  A  + GP     K    G    +
Sbjct: 1376 RQASSA-VRDSGHRGSSGSQVTNSEGHSEDSDTQSVSAHGQAGPHQQSHKESARGQSGES 1434

Query: 743  PPRRR--------RRAQDDSQRRSLPAEEGSSGKKDEGGGGSS--SQDHGGRKHKGELPP 792
              R R            + +  ++ P+  G  G + E    SS  S    G+      P 
Sbjct: 1435 SGRSRSFLYQVSSHEQSESTHGQTAPSTGGRQGSRHEQARNSSRHSASQDGQDTIRGHPG 1494

Query: 793  SSCQRRAGTKRSS---RSSHRSQPSSGD--EDSDDASSHRLHQKSPSQYSEEEEEEDSGS 847
            SS   R G+       RS H     S    +   DAS  +   +S S+ +  EE+   GS
Sbjct: 1495 SSRGGRQGSYHEQSVDRSGHSGYHHSHTTPQGRSDASHGQSGPRSASRQTRNEEQSGDGS 1554

Query: 848  EHSRSR-----SRSGR-RHS---------SHRSSRRSYSSSSDASSD---QSCYSRQRSY 889
             HS SR     +R+G  RHS         S  S R+  S S D  S+   +    R  S 
Sbjct: 1555 RHSGSRHHEPSTRAGSSRHSQVGQGESAGSKTSRRQGSSVSQDRDSEGHSEDSERRSESA 1614

Query: 890  SDDSYSDYSDRSRRHSK--RSHDSDDSDYA----SSKHRSKRHKYSSSDDDYSLSCSQSR 943
            S + Y    ++SR  S+  RSH  D + +     SS+    RH  +SS      + SQ +
Sbjct: 1615 SRNHYGSAREQSRHGSRNPRSHQEDRASHGHSAESSRQSGTRHAETSSGG--QAASSQEQ 1672

Query: 944  SRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRS---------------- 987
            +RS    R  SR + +S  SS      +R+  S    S  R  S                
Sbjct: 1673 ARSSPGERHGSRHQ-QSADSSTDSGTGRRQDSSVVGDSGNRGSSGSQASDSEGHSEESDT 1731

Query: 988  -----------YSRDRSRSTRSPSQRSGSRKRSW-----GHESPEERH------SGRRDF 1025
                       + +    STR  S     R  S+      HE  E  H      +G R  
Sbjct: 1732 QSVSAHGQAGPHQQSHQESTRGQSGERSGRSGSFLYQVSTHEQSESAHGRTGPSTGGRQR 1791

Query: 1026 IRSKIYRSQSPH------------YFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTG 1073
             R +  R  S H            +  S RG   G   +   D S  +G  S +S+  + 
Sbjct: 1792 SRHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHYEQSVDSSGHSG--SHHSHTTSQ 1849

Query: 1074 RGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPNKAGPKLKDPPQGY-FG 1132
              S+         SV+ +   EK QS    R  S S   +A+      +     QG   G
Sbjct: 1850 ERSDVSRGQSGSRSVSRQTRNEK-QSGDGSRH-SGSRHHEASSRADSSRHSQVGQGQSSG 1907

Query: 1133 PKLPPSLGNKPVLPLIGKLPATRKPNKKCEESGLERGEEQEQSETEEGPPGS---SDALF 1189
            P+   + G+        +  +          S    G   EQS      PGS     A  
Sbjct: 1908 PRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHLGSAWEQSRDGSRHPGSHHEDRAGH 1967

Query: 1190 GHQFPSEETTGPLLDPPPEESKSGEATADHPVAPLGTPAHSDCYPGDPTISHNYLPDPSD 1249
            GH   S   +G       E S  G+A + H  A            G+   SH+       
Sbjct: 1968 GHSADSSRQSG---TRHTESSSRGQAASSHEQARSSA--------GERHGSHH------- 2009

Query: 1250 GDTLESLDSSSQPGPVESSLLPIAPDLEHFPSYAPPSGDPSIESTDGAEDASLAPLESQP 1309
               L+S DSS   G           D  H       SG  + +S   +ED+    + +Q 
Sbjct: 2010 --QLQSADSSRHSGIGHGQASSAVRDSGH----RGYSGSQASDSEGHSEDSDTQSVSAQG 2063

Query: 1310 ITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASAAL----APATPALQPIHIQQPA 1365
                 ++  K S   Q+ +   +      QV     S +     AP+T   Q  H  Q  
Sbjct: 2064 KAGPHQQSHKESARGQSGESSGRSGSFLYQVSTHEQSESTHGQSAPSTGGRQGSHYDQAQ 2123

Query: 1366 TASATSITTVQHAILQHHAAAAAAAIGIHPHPHP 1399
             +S              H+A+      I  HP P
Sbjct: 2124 DSS-------------RHSASQEGQDTIRGHPGP 2144



 Score = 94.7 bits (234), Expect = 6e-19
 Identities = 177/779 (22%), Positives = 286/779 (36%), Gaps = 94/779 (12%)

Query: 417  SEQMDGDNTTHP--KNAPESKKGSSPKPKSCIKAAA--SQGAEKTVSEVSEQPKETSMTE 472
            +E+  GD++ H   ++   S      +    ++  +  S+ + +  S VS+       +E
Sbjct: 3167 NEEQSGDSSRHSVSRHHEASTHADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSE 3226

Query: 473  PSEPGSKAEAKKALGGDVSDQSLES--HSQKVSETQMCESNSSKETSLATPAGKESQEGP 530
             SE  S   A +   G V +QS     H +   E +    +S         A +  Q G 
Sbjct: 3227 DSERWS-GSASRNHRGSVQEQSRHGSRHPRSHHEDRAGHGHS---------ADRSRQSGT 3276

Query: 531  KHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDAR---TK 587
            +H         +     A   P E       + + S   + +      S  +D+R   + 
Sbjct: 3277 RHAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRGQASSAVRDSRHWGSS 3336

Query: 588  GTEKPKDIGSSSKDHLQGLDP-GEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQE 646
            G++     G S +   Q +   G+    ++   E     SGGR  +  SGS    ++  E
Sbjct: 3337 GSQASDSEGHSEESDTQSVSGHGQAGPHQQSHQESARDRSGGR--SGRSGSFLYQVSTHE 3394

Query: 647  PGGS-HGSETEDTGRSLPSKKERSGKSHRHKKKKK-------HKKSSKHKRK-----HKA 693
               S HG     TGR   S  E++  S RH   ++       H  SS+  R+        
Sbjct: 3395 QSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRRGRQGSHYEQSV 3454

Query: 694  DTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDD 753
            D    S    S   S+ R    R ++ S + +   R  +    GS            Q D
Sbjct: 3455 DRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRQTRNDEQSGDGSRHSWSHHHEASTQAD 3514

Query: 754  SQRRSLPAEEGSSGKKDEGGGGSS-SQDHGGRKHKGELP----PSSCQRRAGTKRSSRSS 808
            S R S   +  S+G +     GSS SQD   + H  +       +S   R   +  SR  
Sbjct: 3515 SSRHSQSGQGQSAGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDG 3574

Query: 809  HRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHR---- 864
             R   S  ++ +    S    ++S + ++E      + S H ++RS +G RH SH     
Sbjct: 3575 SRHPTSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSA 3634

Query: 865  -SSRRS---YSSSSDASSDQSCYSRQRSYSDDS--YSDYSD--------RSRRHSKRSHD 910
             SSR S   +  +S A  D        S + DS  +S+ SD        ++  H +   +
Sbjct: 3635 DSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQE 3694

Query: 911  SDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSR---SRGRSRSSSCSR 967
            S     A    RS    Y  S  + S S +  R+   +  R+ SR   +R  SR S+   
Sbjct: 3695 STRGRSAGRSGRSGSFLYQVSTHEQSES-AHGRAGPSTGGRQGSRHEQARDSSRHSASQE 3753

Query: 968  SR--------SKRRSRSTTAHSWQRSR--------SYSRDRSRSTRSPSQRSGSRKRSWG 1011
             +        S+R  R  + H     R        S++  + RS  S  Q SGSR  S  
Sbjct: 3754 GQDTIRGHPGSRRGGRQGSYHEQSVDRSGHSGSHHSHTTSQGRSDASHGQ-SGSRSASRE 3812

Query: 1012 HESPEE-----RHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQ 1066
              + E+     RHSG R    S   ++ S  + +SG+GE  G +   R   S +    S+
Sbjct: 3813 TRNEEQSGDGSRHSGSRHHEAST--QADSSRHSQSGQGESAGSRRSRRQGSSVSQDSDSE 3870

Query: 1067 NSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPNKAGPKLKD 1125
                 + R SE        +S        + QSR   R P  S    A+  ++ P   D
Sbjct: 3871 AYPEDSERRSESASRNHHGSS--------REQSRDGSRHPGSSHRDTASHVQSSPVQSD 3921



 Score = 94.4 bits (233), Expect = 8e-19
 Identities = 134/602 (22%), Positives = 211/602 (35%), Gaps = 119/602 (19%)

Query: 586  TKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQ 645
            + G++     G S     Q +        ++   ++  R   G     +  S       +
Sbjct: 417  SSGSQASDSEGHSENSDTQSVSGHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQVSTHE 476

Query: 646  EPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKK--------------------HKKS- 684
            +P  +HG     TG    S  E++  S RH   ++                    H++S 
Sbjct: 477  QPDSAHGRTGTSTGGRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHHEQSV 536

Query: 685  --SKHKRKHKADTEEK----SSKAESGEKSKKRKKRKRKK------------NKSSAPAD 726
              S H   H + T  +    +S  +SG +S  R+ R  ++            +++S+ AD
Sbjct: 537  NRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRNEEQSGDGTRHSGSRHHEASSQAD 596

Query: 727  SERGPKPEPPGSGSPAPPRRRRR-----AQD-DSQRRSLPAEEGSSGKKDEGGGGSSSQD 780
            S R  +    G G  + PR  R      +QD DSQ  S  +E  S        G +  Q 
Sbjct: 597  SSRHSQ---VGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHHGSAQEQS 653

Query: 781  HGGRKH--------KGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDA-----SSHR 827
              G +H         G    +   R++GT+ +  SS     SS ++    A     S H+
Sbjct: 654  RDGSRHPRSHHEDRAGHGHSADSSRKSGTRHTQNSSSGQAASSHEQARSSAGERHGSRHQ 713

Query: 828  LHQKSPSQYS--------------------------EEEEEEDSGSEHSRSRSRSGRRHS 861
            L     S++S                           E   EDS ++      ++G    
Sbjct: 714  LQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQATDSEGHSEDSDTQSVSGHGQAGHHQQ 773

Query: 862  SHRSSRRSYSSSSDASSDQSCY---SRQRSYSDDSYS---------DYSDRSRRHSKRSH 909
            SH+ S R  S      S    Y   + ++S S   ++          + +++R +S+ S 
Sbjct: 774  SHQESARDRSGERSRRSGSFLYQVSTHKQSESSHGWTGPSTGVRQGSHHEQARDNSRHSA 833

Query: 910  DSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSR---SRGRSRSSSCS 966
              D  D       S R     S  + S+  S       SHT  + R   SRG+S S S S
Sbjct: 834  SQDGQDTIRGHPGSSRRGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSAS 893

Query: 967  R-SRSKRRSRSTTAHSWQRSRSYS--RDRSR-STRSPSQRSGSR------------KRSW 1010
            R +R++ +SR  + HS  R    S   D SR S     Q  GSR              S 
Sbjct: 894  RTTRNEEQSRDGSRHSGSRHHEASSHADISRHSQAGQGQSEGSRTSRRQGSSVSQDSDSE 953

Query: 1011 GHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGR-GDDSKATGPPSQNSN 1069
            GH    ER SG          + QS H  R  R     +   G   D S+ +G P   ++
Sbjct: 954  GHSEDSERWSGSASRNHRGSAQEQSRHGSRHPRSHHEDRAGHGHSADSSRQSGTPHAETS 1013

Query: 1070 IG 1071
             G
Sbjct: 1014 SG 1015



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 109/499 (21%), Positives = 177/499 (35%), Gaps = 41/499 (8%)

Query: 579  SRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSA 638
            S+ +   ++G    +    ++++  Q  D    + S+    E    +   R      G +
Sbjct: 2821 SQGRSDASRGQSGSRSASRTTRNEEQSGDGSRHSGSRH--HEASTHADISRHSQAVQGQS 2878

Query: 639  CSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRH--KKKKKHKKSSKHKRKHKADTE 696
                  +  G S   +++  G S  S++     S  H    +++ +  S+H R H+ D  
Sbjct: 2879 EGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRA 2938

Query: 697  EKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQR 756
                 A+S  +S  R  +     ++++  +  R    E  GS         +++ D S+ 
Sbjct: 2939 GHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGS-------HHQQSADSSRH 2991

Query: 757  RSLPAEEGSSGKKDEGG---GGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQP 813
              +   + SS  +D G     GS + D+ G     +    S   +AG   S + SH+   
Sbjct: 2992 SGIGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQAG---SHQQSHQESA 3048

Query: 814  SSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSS 873
                 ++   S   L+Q S    + E+ E   G     +R R G RH   + S R  +S 
Sbjct: 3049 RGRSGETSGHSGSFLYQVS----THEQSESSHGWTGPSTRGRQGSRHEQAQDSSRHSAS- 3103

Query: 874  SDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDD 933
                           Y  D+   +   SR   +  H     D  SS H    H +++S  
Sbjct: 3104 --------------QYGQDTIRGHPGSSRGGRQGYHHEHSVD--SSGHSGSHHSHTTSQG 3147

Query: 934  DYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRS 993
                S  QS SRS S T       G S   S SR          + HS Q  +  S    
Sbjct: 3148 RSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEASTHADISRHS-QAVQGQSEGSR 3206

Query: 994  RSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDG 1053
            RS R  S  S     S GH    ER SG          + QS H  R  R     +   G
Sbjct: 3207 RSRRQGSSVS-QDSDSEGHSEDSERWSGSASRNHRGSVQEQSRHGSRHPRSHHEDRAGHG 3265

Query: 1054 R-GDDSKATGPPSQNSNIG 1071
               D S+ +G     ++ G
Sbjct: 3266 HSADRSRQSGTRHAETSSG 3284



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 123/500 (24%), Positives = 190/500 (38%), Gaps = 74/500 (14%)

Query: 624  RSSGGRMDAPASGSACSGLNKQEPGGSHGSETE-DTGRSLPSKKERSGKS---------- 672
            R SG R    +S +  SG ++   G S G  T  + G S     +  G S          
Sbjct: 2528 RHSGSRHHEASSRADSSGHSQVGQGQSEGPRTSRNWGSSFSQDSDSQGHSEDSERWSGSA 2587

Query: 673  ---HRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSER 729
               H    +++ +  S+H R H+ D       A+S  +S  R  +     ++++  +  R
Sbjct: 2588 SRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQAR 2647

Query: 730  GPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGG---GGSSSQDHGGRKH 786
                E  GS         +++ D S+   +   + SS  +D G     GS + D+ G   
Sbjct: 2648 SSAGERHGS-------HHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSE 2700

Query: 787  KGELPPSSCQRRAGTKRSSRSSH---RSQPSSGDEDS--DDASSHRLHQKS-----PS-- 834
              +    S   +AG+ + S       RS  +SG   S     S+H   + S     PS  
Sbjct: 2701 DSDTQSVSAHGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTR 2760

Query: 835  --QYSEEEEEEDSGSEHSRSR------------SRSGRRHSSHRSSRRSYSSSSDASSDQ 880
              Q S  E+ +DS S HS S+            SR GR+   H  S  S   S    S  
Sbjct: 2761 GRQGSRHEQAQDS-SRHSASQDGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHT 2819

Query: 881  SCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYS--LS 938
            +   R  +    S S  + R+ R+ ++S D        S+H   RH  +S+  D S    
Sbjct: 2820 TSQGRSDASRGQSGSRSASRTTRNEEQSGD-------GSRHSGSRHHEASTHADISRHSQ 2872

Query: 939  CSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRS 998
              Q +S     +R +  S  +   S      S+R S S + +    ++   RD SR  RS
Sbjct: 2873 AVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHHGSAQEQLRDGSRHPRS 2932

Query: 999  PSQ-RSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPH-YFRSGRGEGPGKKDDGRGD 1056
              + R+G      GH +   R SG R    S   ++ S H   RS  GE  G       D
Sbjct: 2933 HQEDRAGH-----GHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSAD 2987

Query: 1057 DSKATGPPSQNSNIGTGRGS 1076
             S+       +S IG G+ S
Sbjct: 2988 SSR-------HSGIGHGQAS 3000



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 123/484 (25%), Positives = 183/484 (37%), Gaps = 102/484 (21%)

Query: 649  GSHGSETEDT-GRSLPSKKERSGKSHRHKKK--KKHKKSSKHKRKHKADTEEKSSKAESG 705
            GS  S+  D+ G S  S++     S  H     ++ +  S+H R H  D       A+S 
Sbjct: 294  GSRVSQDRDSEGHSEDSERHSGSASRNHHGSAWEQSRDGSRHPRSHDEDRASHGHSADSS 353

Query: 706  EKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGS 765
             +S  R      + ++++  +  R    E  GSG        +++ D S+  +    + S
Sbjct: 354  RQSGTRHAETSSRGQTASSHEQARSSPGERHGSG-------HQQSADSSRHSATGRGQAS 406

Query: 766  SGKKDEGGGGSS---SQDHGGRKHKGELPPSSCQRRAGTKRSS-------RSSHRS---- 811
            S   D G  GSS   + D  G     +    S   +AG ++ S       RS  RS    
Sbjct: 407  SAVSDRGHRGSSGSQASDSEGHSENSDTQSVSGHGKAGLRQQSHQESTRGRSGERSGRSG 466

Query: 812  ----------QPSS-----GDEDSDDASSHRLHQKSPSQYSEEEEEEDS----------- 845
                      QP S     G        SH    +  S++S  +E +D+           
Sbjct: 467  SSLYQVSTHEQPDSAHGRTGTSTGGRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRGG 526

Query: 846  --GSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQS---CYSRQRSYSDDSYSDYSDR 900
              GS H +S +RSG  HS    S  +    SDAS  QS     SRQ    + S       
Sbjct: 527  RQGSHHEQSVNRSG--HSGSHHSHTTSQGRSDASHGQSGSRSASRQTRNEEQSGDGTRHS 584

Query: 901  SRRHSKRSHDSDDSDYA------SSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERS 954
              RH + S  +D S ++      SS  R+ R++ SS   D         S S+ H+ +  
Sbjct: 585  GSRHHEASSQADSSRHSQVGQGQSSGPRTSRNQGSSVSQD---------SDSQGHSEDSE 635

Query: 955  RSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQ-RSGSRKRSWGHE 1013
            R  G       S SR+   S          ++  SRD SR  RS  + R+G      GH 
Sbjct: 636  RWSG-------SASRNHHGS----------AQEQSRDGSRHPRSHHEDRAGH-----GHS 673

Query: 1014 SPEERHSGRRDFIRSKIYRSQSPH-YFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGT 1072
            +   R SG R    S   ++ S H   RS  GE  G +   +  DS      S++S  G 
Sbjct: 674  ADSSRKSGTRHTQNSSSGQAASSHEQARSSAGERHGSRHQLQSADS------SRHSGTGH 727

Query: 1073 GRGS 1076
            G+ S
Sbjct: 728  GQAS 731



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 161/790 (20%), Positives = 279/790 (35%), Gaps = 114/790 (14%)

Query: 340  DQGLQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPP 399
            +Q +   G S    +    +E  D   G S + ++S+  R +++ G G+      H+   
Sbjct: 1830 EQSVDSSGHSGSHHSHTTSQERSDVSRGQSGSRSVSRQTRNEKQSGDGSRHSGSRHHEAS 1889

Query: 400  AHCKVKPNFPFLLFMRASEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVS 459
            +      +           Q  G  T+  + +  S+   S       +  +   +   + 
Sbjct: 1890 SRADSSRHSQV-----GQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHLG 1944

Query: 460  EVSEQPKETSMTEPSEPGSKAEAKKALG--GDVSDQSLESHSQKVSETQMCESNSSKETS 517
               EQ ++ S      PGS  E +   G   D S QS   H++  S  Q   S+    +S
Sbjct: 1945 SAWEQSRDGSR----HPGSHHEDRAGHGHSADSSRQSGTRHTESSSRGQAASSHEQARSS 2000

Query: 518  LATPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFK 577
                       G +H  G    + S D S         +   +A  ++  S +  Y   +
Sbjct: 2001 A----------GERH--GSHHQLQSADSSR-----HSGIGHGQASSAVRDSGHRGYSGSQ 2043

Query: 578  LS----RNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAP 633
             S     ++D+ T+        G   + H +    G+  +S    G  + + S       
Sbjct: 2044 ASDSEGHSEDSDTQSVSAQGKAGPHQQSHKESAR-GQSGESSGRSGSFLYQVSTHEQSES 2102

Query: 634  ASGSACSGLNKQEPGGSHGSETEDTGRSLPSKK-----------ERSGK--SHRHKKKKK 680
              G +      ++  GSH  + +D+ R   S++            R G+  SH+ +   +
Sbjct: 2103 THGQSAPSTGGRQ--GSHYDQAQDSSRHSASQEGQDTIRGHPGPSRGGRQGSHQEQSVDR 2160

Query: 681  HKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGS 740
               S  H     +     +S+ +SG +S  RK   ++++                 G GS
Sbjct: 2161 SGHSGSHHSHTTSQGRSDASRGQSGSRSASRKTYDKEQS-----------------GDGS 2203

Query: 741  PAPPRRRRRAQD--DSQRRSLPAEEGSSGKKDEGGGGSS-SQDHGGRKHKGELPPSSCQR 797
                     A    DS R SL  +  SSG +     GSS SQD     H  +        
Sbjct: 2204 RHSGSHHHEASSWADSSRHSLVGQGQSSGPRTSRPRGSSVSQDSDSEGHSED-------- 2255

Query: 798  RAGTKRSSRSSHRSQPSSGDEDSDDASSH-RLH--------------QKSPSQYSEEEEE 842
               ++R S S+ R+   S  E S D S H R H              ++S + ++E    
Sbjct: 2256 ---SERRSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAESSRQSGTHHAENSSG 2312

Query: 843  EDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSR 902
              + S H ++RS +G RH SH       S  S     Q+  + + S    S    +  S 
Sbjct: 2313 GQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSE 2372

Query: 903  RHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRS-RGRSR 961
             HS+ S     S +  +    + H+ S+       S        +  T E+S S  GR+ 
Sbjct: 2373 GHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRTG 2432

Query: 962  SSSCSRSRS-KRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSW--------GH 1012
            +S+  R  S  +++R ++ HS     +    +      P   SG R+ S         GH
Sbjct: 2433 TSTGGRQGSHHKQARDSSRHS-----TSQEGQDTIHGHPGSSSGGRQGSHYEQLVDRSGH 2487

Query: 1013 ESPEERHS---GRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDG-RGDDSKATGPPSQNS 1068
                  H+   GR D          +    R+    G G +  G R  ++ +    S +S
Sbjct: 2488 SGSHHSHTTSQGRSDASHGHSGSRSASRQTRNDEQSGDGSRHSGSRHHEASSRADSSGHS 2547

Query: 1069 NIGTGRGSEG 1078
             +G G+ SEG
Sbjct: 2548 QVGQGQ-SEG 2556



 Score = 87.4 bits (215), Expect = 9e-17
 Identities = 167/760 (21%), Positives = 245/760 (32%), Gaps = 152/760 (20%)

Query: 423  DNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSEPGSKAEA 482
            D   H  +A  S++  +   +S  +  A+   E+  S   E+       + ++    +  
Sbjct: 1963 DRAGHGHSADSSRQSGTRHTESSSRGQAASSHEQARSSAGERHGSHHQLQSAD----SSR 2018

Query: 483  KKALG-GDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQEGPKHPTGPFFPVL 541
               +G G  S    +S  +  S +Q  +S    E S       + + GP           
Sbjct: 2019 HSGIGHGQASSAVRDSGHRGYSGSQASDSEGHSEDSDTQSVSAQGKAGPHQQ-------- 2070

Query: 542  SKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDAR-TKGTEKPKDIGSSSK 600
            S  ES   Q             S   S     F +++S ++ +  T G   P   G    
Sbjct: 2071 SHKESARGQ-------------SGESSGRSGSFLYQVSTHEQSESTHGQSAPSTGGRQGS 2117

Query: 601  DHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACS-GLNKQEPGGSHGSETEDTG 659
             + Q  D    + S+E  G+  +R   G       GS     +++    GSH S T   G
Sbjct: 2118 HYDQAQDSSRHSASQE--GQDTIRGHPGPSRGGRQGSHQEQSVDRSGHSGSHHSHTTSQG 2175

Query: 660  RSLPSK--------------KERSGKSHRHKKKKKHKKSS------------------KH 687
            RS  S+              KE+SG   RH     H+ SS                  + 
Sbjct: 2176 RSDASRGQSGSRSASRKTYDKEQSGDGSRHSGSHHHEASSWADSSRHSLVGQGQSSGPRT 2235

Query: 688  KRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPK------PEPPGSGSP 741
             R   +   + S      E S++R     + +  SA   S  G +       +  G G  
Sbjct: 2236 SRPRGSSVSQDSDSEGHSEDSERRSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHS 2295

Query: 742  APPRRR---RRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKG--ELPPSSCQ 796
            A   R+     A++ S  ++  + E +     E  G    Q     +H G      SS  
Sbjct: 2296 AESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAV 2355

Query: 797  RRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEE--------------- 841
            R +G  R S  S  S      EDSD  S     Q  P Q S +E                
Sbjct: 2356 RDSG-HRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSF 2414

Query: 842  ------EEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYS 895
                   E S S H R+ + +G R  SH    R  S  S +   Q             + 
Sbjct: 2415 LYQVSTHEQSESAHGRTGTSTGGRQGSHHKQARDSSRHSTSQEGQDTIH--------GHP 2466

Query: 896  DYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSR 955
              S   R+ S      D S ++ S H    H  S    D S   S SRS SR    +   
Sbjct: 2467 GSSSGGRQGSHYEQLVDRSGHSGSHHS---HTTSQGRSDASHGHSGSRSASRQTRNDEQS 2523

Query: 956  SRGRSRSSSCSRSRSKRRSRS-------------TTAHSW-------QRSRSYSRDRSRS 995
              G   S S     S R   S              T+ +W         S+ +S D  R 
Sbjct: 2524 GDGSRHSGSRHHEASSRADSSGHSQVGQGQSEGPRTSRNWGSSFSQDSDSQGHSEDSERW 2583

Query: 996  TRSPSQ----------RSGSR--------KRSWGHESPEERHSGRRDFIRSKIYRSQSPH 1037
            + S S+          R GSR        +   GH +   R SG R    S   ++ S H
Sbjct: 2584 SGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAASSH 2643

Query: 1038 -YFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGS 1076
               RS  GE  G       D S+       +S IG G+ S
Sbjct: 2644 EQARSSAGERHGSHHQQSADSSR-------HSGIGHGQAS 2676



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 163/756 (21%), Positives = 262/756 (34%), Gaps = 137/756 (18%)

Query: 416  ASEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSE 475
            ++++   D + HP++  E + G     +S  ++        +  + +   ++   +    
Sbjct: 2270 SAQEQSRDGSRHPRSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGER 2329

Query: 476  PGS----KAEAKKALG---GDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQE 528
             GS     A++ +  G   G  S    +S  +  S +Q  +S    E S         Q 
Sbjct: 2330 HGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQA 2389

Query: 529  GPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTK- 587
            GP           S  EST  +             S   S     F +++S ++ + +  
Sbjct: 2390 GPHQQ--------SHQESTRGR-------------SAGRSGRSGSFLYQVSTHEQSESAH 2428

Query: 588  GTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVR-----SSGGRMDAPASGSACSGL 642
            G       G     H Q  D    + S+E  G+  +      SSGGR             
Sbjct: 2429 GRTGTSTGGRQGSHHKQARDSSRHSTSQE--GQDTIHGHPGSSSGGRQ------------ 2474

Query: 643  NKQEPGGSHGSETED------TGRSLPSKKERSGKSHRHKKKK----------------K 680
                  GSH  +  D      +  S  + + RS  SH H   +                +
Sbjct: 2475 ------GSHYEQLVDRSGHSGSHHSHTTSQGRSDASHGHSGSRSASRQTRNDEQSGDGSR 2528

Query: 681  HKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKR------KRKKNKSSAPADSER----- 729
            H  S  H+   +AD+   S   + G+    R  R       +  +      DSER     
Sbjct: 2529 HSGSRHHEASSRADSSGHSQVGQ-GQSEGPRTSRNWGSSFSQDSDSQGHSEDSERWSGSA 2587

Query: 730  -----GPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGR 784
                 G   E    GS  P   +              + G+   +   GG ++S     R
Sbjct: 2588 SRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQAR 2647

Query: 785  KHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEE-EEE 843
               GE   S  Q+ A + R S   H  Q SS   D    S HR +  S SQ S+ E   E
Sbjct: 2648 SSAGERHGSHHQQSADSSRHSGIGH-GQASSAVRD----SGHRGY--SGSQASDNEGHSE 2700

Query: 844  DSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCY---SRQRSYSDDSYSDYSDR 900
            DS ++   +  ++G    SH+ S R  S  +   S    Y   + ++S S   ++  S R
Sbjct: 2701 DSDTQSVSAHGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTR 2760

Query: 901  SRRHSKRSHDSDDSDYASSKH---------RSKRHKYSSSDDDYSLSCSQSRSRSRSHTR 951
             R+ S+     D S +++S+           S R        ++S+  S       SHT 
Sbjct: 2761 GRQGSRHEQAQDSSRHSASQDGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTT 2820

Query: 952  ERSR---SRGRSRSSSCSR-SRSKRRSRSTTAHSWQRSRSYS--RDRSRSTRS-PSQRSG 1004
             + R   SRG+S S S SR +R++ +S   + HS  R    S   D SR +++   Q  G
Sbjct: 2821 SQGRSDASRGQSGSRSASRTTRNEEQSGDGSRHSGSRHHEASTHADISRHSQAVQGQSEG 2880

Query: 1005 SRKR------------SWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDD 1052
            SR+             S GH    ER SG      S+ +   +    R G       ++D
Sbjct: 2881 SRRSRRQGSSVSQDSDSEGHSEDSERWSGS----ASRNHHGSAQEQLRDGSRHPRSHQED 2936

Query: 1053 GRGDDSKA-TGPPSQNSNIGTGRGSEGDCSPEDKNS 1087
              G    A +   S   +  T  G +   S E   S
Sbjct: 2937 RAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARS 2972



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 118/475 (24%), Positives = 185/475 (38%), Gaps = 56/475 (11%)

Query: 649  GSHGSETEDTGRSLPSK------KERSGKSHRHKKKKKHKKS---SKHKRKHKADTEEK- 698
            GSH  +  D  R   S+      +   G S R ++   H++S   S H   H + T  + 
Sbjct: 819  GSHHEQARDNSRHSASQDGQDTIRGHPGSSRRGRQGSHHEQSVDRSGHSGSHHSHTTSQG 878

Query: 699  ---SSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQ 755
               +S+ +SG +S  R  R  ++++  +     R  +       S    R  +  Q  S+
Sbjct: 879  RSDASRGQSGSRSASRTTRNEEQSRDGSRHSGSRHHEASSHADIS----RHSQAGQGQSE 934

Query: 756  RRSLPAEEGSSGKKDEGGGGSSSQDH-----GGRKHKGELPPSSCQRRAGTKRSSRSSHR 810
                   +GSS  +D    G S           R H+G     S   R G+ R  RS H 
Sbjct: 935  GSRTSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSAQEQS---RHGS-RHPRSHHE 990

Query: 811  SQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSS-HRSSRRS 869
             +   G   S D+S     ++S + ++E      + S H ++RS  G RH S H+ S  S
Sbjct: 991  DRAGHGH--SADSS-----RQSGTPHAETSSGGQAASSHEQARSSPGERHGSRHQQSADS 1043

Query: 870  YSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYS 929
               S       S   R   +   S S  SD S  HS+ S     S +       + H+ S
Sbjct: 1044 SRHSGIPRRQASSAVRDSGHWGSSGSQASD-SEGHSEESDTQSVSGHGQDGPHQQSHQES 1102

Query: 930  SSDDDYSLSCSQSRSRSRSHTRERSRS-RGRSRSSSCSRSRS-KRRSRSTTAHSWQRSRS 987
            + D     S        +  T E+S S  GR+R+S+  R  S   ++R ++ HS   +  
Sbjct: 1103 ARDWSGGRSGRSGSFIYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHS---ASQ 1159

Query: 988  YSRDRSRSTRSPSQRSGSRKRSWGHESPEER--HSGRRDFIRSKIYRSQSPHYFRSGRGE 1045
              +D  R+   P  R G R+ S  HE   +R  HSG      +   RS + H     R  
Sbjct: 1160 EGQDTIRA--HPGSRRGGRQGS-HHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSA 1216

Query: 1046 G-PGKKDDGRGDDSKATG----------PPSQNSNIGTGRGSEGDCSPEDKNSVT 1089
                +KD   GD S+ +G            S++S +G  + S    S    +SV+
Sbjct: 1217 SRQTRKDKQSGDGSRHSGSRHHEAASWADSSRHSQVGQEQSSGSRTSRHQGSSVS 1271



 Score = 85.1 bits (209), Expect = 5e-16
 Identities = 159/743 (21%), Positives = 268/743 (36%), Gaps = 115/743 (15%)

Query: 416  ASEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSE 475
            +  + +  +  H  +A E  +  S  P+S  +  AS G     S  S +   T   E S 
Sbjct: 1607 SERRSESASRNHYGSAREQSRHGSRNPRSHQEDRASHGH----SAESSRQSGTRHAETSS 1662

Query: 476  PGSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQEGPKHPTG 535
             G  A +++       ++    H Q    +    +   +++S+   +G     G +    
Sbjct: 1663 GGQAASSQEQARSSPGERHGSRHQQSADSSTDSGTGRRQDSSVVGDSGNRGSSGSQASDS 1722

Query: 536  PFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPL----YFDFKLSRNKDARTK-GTE 590
                  S  +S +    +     +  E +   S         F +++S ++ + +  G  
Sbjct: 1723 EGHSEESDTQSVSAHGQAGPHQQSHQESTRGQSGERSGRSGSFLYQVSTHEQSESAHGRT 1782

Query: 591  KPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGS 650
             P   G     H Q  D    + S+E  G+  +R           GS+  G       GS
Sbjct: 1783 GPSTGGRQRSRHEQARDSSRHSASQE--GQDTIRGH--------PGSSRGGRQ-----GS 1827

Query: 651  HGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKK 710
            H  ++ D+          SG  H H   ++    S+ +   ++ + +  ++ +SG+ S+ 
Sbjct: 1828 HYEQSVDS-------SGHSGSHHSHTTSQERSDVSRGQSGSRSVSRQTRNEKQSGDGSRH 1880

Query: 711  RKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRR-----AQD-DSQRRSLPAE-- 762
               R    +++S+ ADS R  +    G G  + PR  R      +QD DSQ  S  +E  
Sbjct: 1881 SGSR---HHEASSRADSSRHSQ---VGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERW 1934

Query: 763  EGSSGKKDEGGGGSSSQD---HGGRKHK---GELPPSSCQRRAGTKRSSRSSHRSQPSSG 816
             GS+ +   G     S+D   H G  H+   G    +   R++GT R + SS R Q +S 
Sbjct: 1935 SGSASRNHLGSAWEQSRDGSRHPGSHHEDRAGHGHSADSSRQSGT-RHTESSSRGQAASS 1993

Query: 817  DEDSDDA------SSHRLHQKSPSQYS--------------------------EEEEEED 844
             E +  +      S H+L     S++S                           E   ED
Sbjct: 1994 HEQARSSAGERHGSHHQLQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDSEGHSED 2053

Query: 845  SGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCY---SRQRSYSDDSYSDYSDRS 901
            S ++   ++ ++G    SH+ S R  S  S   S    Y   + ++S S    S  S   
Sbjct: 2054 SDTQSVSAQGKAGPHQQSHKESARGQSGESSGRSGSFLYQVSTHEQSESTHGQSAPSTGG 2113

Query: 902  RRHSKRSHDSDDSDYASSKHRS---------KRHKYSSSDDDYSLSCSQSRSRSRSHTRE 952
            R+ S      D S +++S+             R     S  + S+  S       SHT  
Sbjct: 2114 RQGSHYDQAQDSSRHSASQEGQDTIRGHPGPSRGGRQGSHQEQSVDRSGHSGSHHSHTTS 2173

Query: 953  RSR---SRGRSRSSSCSR-----SRSKRRSRSTTAH-----SWQRSRSYS---RDRSRST 996
            + R   SRG+S S S SR      +S   SR + +H     SW  S  +S   + +S   
Sbjct: 2174 QGRSDASRGQSGSRSASRKTYDKEQSGDGSRHSGSHHHEASSWADSSRHSLVGQGQSSGP 2233

Query: 997  RSPSQRSGSRKR---SWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDG 1053
            R+   R  S  +   S GH    ER SG          + QS    R  R     +   G
Sbjct: 2234 RTSRPRGSSVSQDSDSEGHSEDSERRSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHG 2293

Query: 1054 RGDDSKATGPPSQNSNIGTGRGS 1076
               +S          N   G+ +
Sbjct: 2294 HSAESSRQSGTHHAENSSGGQAA 2316



 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 137/622 (22%), Positives = 222/622 (35%), Gaps = 129/622 (20%)

Query: 579  SRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSA 638
            S+ +   ++G    +    ++++  Q  D    + S+    E    +   R      G +
Sbjct: 876  SQGRSDASRGQSGSRSASRTTRNEEQSRDGSRHSGSRH--HEASSHADISRHSQAGQGQS 933

Query: 639  CSGLNKQEPGGSHGSETEDTGRSLPSKK--ERSGKSHRHKKKKKHKKSSKHKRKHKADTE 696
                  +  G S   +++  G S  S++    + ++HR   +++ +  S+H R H  D  
Sbjct: 934  EGSRTSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSAQEQSRHGSRHPRSHHEDRA 993

Query: 697  EKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQR 756
                 A+S  +S           ++++  +  R    E  GS       R +++ D S+ 
Sbjct: 994  GHGHSADSSRQSGTPHAETSSGGQAASSHEQARSSPGERHGS-------RHQQSADSSRH 1046

Query: 757  RSLPAEEGSSGKKDEGGGG------SSSQDH----------------------------- 781
              +P  + SS  +D G  G      S S+ H                             
Sbjct: 1047 SGIPRRQASSAVRDSGHWGSSGSQASDSEGHSEESDTQSVSGHGQDGPHQQSHQESARDW 1106

Query: 782  -GGRKHKG-----------ELPPSSCQRRAGTKRSSRSSHR-----SQPSSGDEDSDDAS 824
             GGR  +            +   +  + R  T R   S H      S+ S+  E  D   
Sbjct: 1107 SGGRSGRSGSFIYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIR 1166

Query: 825  SHRLHQKSPSQYSEEEEEED----SGSEHS------------------------RSRSRS 856
            +H   ++   Q S  E+  D    SGS HS                        R   +S
Sbjct: 1167 AHPGSRRGGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRKDKQS 1226

Query: 857  GRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDY 916
            G   S H  SR   ++S   SS  S   +++S           R+ RH + S  S DSD 
Sbjct: 1227 G-DGSRHSGSRHHEAASWADSSRHSQVGQEQS--------SGSRTSRH-QGSSVSQDSD- 1275

Query: 917  ASSKHRSKRHKYSSSDDDYSLSCSQSRSR---SRSHTRERSRSRGRSRSSSCSRSRSKRR 973
                  S+RH    SDD   LS S SR+    SR  +R+ SR  G  +    S   S   
Sbjct: 1276 ------SERH----SDDSERLSGSASRNHHGSSREQSRDGSRHPGFHQEDRASHGHSADS 1325

Query: 974  SRSTTAHSWQRSRS----YSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSK 1029
            SR +  H  + S       S +++RS  SP +R GSR +     +   RHSG      S 
Sbjct: 1326 SRQSGTHHTESSSHGQAVSSHEQARS--SPGERHGSRHQ---QSADSSRHSGIGHRQASS 1380

Query: 1030 IYRSQSPHYFRSG----RGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDK 1085
              R  S H   SG      EG  +  D +   +     P Q S+  + RG  G+ S   +
Sbjct: 1381 AVR-DSGHRGSSGSQVTNSEGHSEDSDTQSVSAHGQAGPHQQSHKESARGQSGESSGRSR 1439

Query: 1086 NSVTAKLLLEKIQSRKVERKPS 1107
            + +      E+ +S   +  PS
Sbjct: 1440 SFLYQVSSHEQSESTHGQTAPS 1461



 Score = 78.2 bits (191), Expect = 6e-14
 Identities = 120/489 (24%), Positives = 180/489 (36%), Gaps = 63/489 (12%)

Query: 659  GRSLPSKKERSGKSHRHKKKKKHKK--SSKHKRKHKADTEEKSSKAESGEKSKKR--KKR 714
            GRS  S +E  GK H    +KK +K  S  H+ +        SSK E  +    R    R
Sbjct: 139  GRS-KSPRETGGKRHESSSEKKERKGYSPTHREEEYGKNHHNSSKKEKNKTENTRLGDNR 197

Query: 715  KRKKNKSSAPADSERGPKP-EPPG--------SGSPAPPRRRRRAQDDSQRRSLPAEEGS 765
            KR   +     D+E G    E  G        SG  A     +    D+    L  EE  
Sbjct: 198  KRLSERLEEKEDNEEGVYDYENTGRMTQKWIQSGHIATYYTIQDEAYDTTDSLL--EENK 255

Query: 766  SGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSR------------------- 806
              ++     G SS      +H+        + R   +R SR                   
Sbjct: 256  IYERSRSSDGKSSSQVNRSRHENTSQVPLQESRTRKRRGSRVSQDRDSEGHSEDSERHSG 315

Query: 807  SSHRSQPSSGDEDSDDASSH-RLH--------------QKSPSQYSEEEEEEDSGSEHSR 851
            S+ R+   S  E S D S H R H              ++S ++++E      + S H +
Sbjct: 316  SASRNHHGSAWEQSRDGSRHPRSHDEDRASHGHSADSSRQSGTRHAETSSRGQTASSHEQ 375

Query: 852  SRSRSGRRH-SSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHD 910
            +RS  G RH S H+ S  S   S+      S     R +   S S  SD S  HS+ S  
Sbjct: 376  ARSSPGERHGSGHQQSADSSRHSATGRGQASSAVSDRGHRGSSGSQASD-SEGHSENSDT 434

Query: 911  SDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRS-RGRSRSSSCSRSR 969
               S +  +  R + H+ S+       S     S  +  T E+  S  GR+ +S+  R  
Sbjct: 435  QSVSGHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQVSTHEQPDSAHGRTGTSTGGRQG 494

Query: 970  S-KRRSRSTTAHS-WQRSRSYSRDR---SRSTRSPSQRSGSRKRSWGHESPEERHS---G 1021
            S   ++R ++ HS  Q  +   R     SR  R  S    S  RS GH      H+   G
Sbjct: 495  SHHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHHEQSVNRS-GHSGSHHSHTTSQG 553

Query: 1022 RRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDG-RGDDSKATGPPSQNSNIGTGRGSEGDC 1080
            R D    +     +    R+    G G +  G R  ++ +    S++S +G G+ S    
Sbjct: 554  RSDASHGQSGSRSASRQTRNEEQSGDGTRHSGSRHHEASSQADSSRHSQVGQGQSSGPRT 613

Query: 1081 SPEDKNSVT 1089
            S    +SV+
Sbjct: 614  SRNQGSSVS 622



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 134/644 (20%), Positives = 233/644 (36%), Gaps = 74/644 (11%)

Query: 415  RASEQMDGDNTT--HPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTE 472
            R S   +G +T   HP ++   ++GS  +    +  +   G+  + +    +   +    
Sbjct: 505  RHSASQEGQDTIRGHPGSSRGGRQGSHHEQS--VNRSGHSGSHHSHTTSQGRSDASHGQS 562

Query: 473  PSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQEGPKH 532
             S   S+    +   GD +  S   H          E++S  ++S  +  G+    GP+ 
Sbjct: 563  GSRSASRQTRNEEQSGDGTRHSGSRHH---------EASSQADSSRHSQVGQGQSSGPR- 612

Query: 533  PTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTKGTEKP 592
                     S+++ +++   S+    ++     S S +  +      +++D    G+  P
Sbjct: 613  --------TSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHHGSAQEQSRD----GSRHP 660

Query: 593  KDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHG 652
            +        H    D      S++ G      SS G+  A +S         +  G  H 
Sbjct: 661  RSHHEDRAGHGHSAD-----SSRKSGTRHTQNSSSGQ--AASSHEQARSSAGERHGSRHQ 713

Query: 653  SETEDTGRSLPSKKERSGKSHR---HKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSK 709
             ++ D+ R   +   ++  + R   H+     + +        +DT+  S   ++G   +
Sbjct: 714  LQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQATDSEGHSEDSDTQSVSGHGQAGHHQQ 773

Query: 710  KRKKRKRKKN-----KSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEG 764
              ++  R ++     +S +        K      G   P    R+     Q R       
Sbjct: 774  SHQESARDRSGERSRRSGSFLYQVSTHKQSESSHGWTGPSTGVRQGSHHEQARDNSRHSA 833

Query: 765  SSGKKD--EGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDD 822
            S   +D   G  GSS +   G  H+  +       R+G   S  S   SQ  S      D
Sbjct: 834  SQDGQDTIRGHPGSSRRGRQGSHHEQSVD------RSGHSGSHHSHTTSQGRS------D 881

Query: 823  ASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSC 882
            AS  +   +S S+ +  EE+   GS HS SR      H+    SR S +    +   ++ 
Sbjct: 882  ASRGQSGSRSASRTTRNEEQSRDGSRHSGSRHHEASSHAD--ISRHSQAGQGQSEGSRTS 939

Query: 883  YSRQRSYSDDSYSD-YSDRSRRHS-KRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCS 940
              +  S S DS S+ +S+ S R S   S +   S    S+H S RH  S  +D      S
Sbjct: 940  RRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSAQEQSRHGS-RHPRSHHEDRAGHGHS 998

Query: 941  QSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPS 1000
               SR +S T     S G   +SS  ++RS    R  + H        S D SR +  P 
Sbjct: 999  ADSSR-QSGTPHAETSSGGQAASSHEQARSSPGERHGSRH------QQSADSSRHSGIPR 1051

Query: 1001 QRSGSRKRSWGH-------ESPEERHSGRRDFIRSKIYRSQSPH 1037
            +++ S  R  GH        S  E HS   D      +    PH
Sbjct: 1052 RQASSAVRDSGHWGSSGSQASDSEGHSEESDTQSVSGHGQDGPH 1095



 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 113/515 (21%), Positives = 178/515 (34%), Gaps = 60/515 (11%)

Query: 578  LSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGS 637
            +S++ D++    +  +  GS+S++H         + S+        R+  G     A  S
Sbjct: 3539 VSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSRHPTSHHEDRAGHGHS---AESS 3595

Query: 638  ACSGLNKQE-PGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTE 696
              SG +  E   G   + + +  RS  S  ER G  H+            H +   A   
Sbjct: 3596 RQSGTHHAENSSGGQAASSHEQARS--SAGERHGSHHQQSADSSRHSGIGHGQASSA-VR 3652

Query: 697  EKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPG-------------SGSPAP 743
            +   +  SG ++   +      +  S  A  + GP  +                SGS   
Sbjct: 3653 DSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLY 3712

Query: 744  PRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSS-------SQD----HGGRKHKGELPP 792
                    + +  R+ P+  G  G + E    SS        QD    H G +  G    
Sbjct: 3713 QVSTHEQSESAHGRAGPSTGGRQGSRHEQARDSSRHSASQEGQDTIRGHPGSRRGGR--Q 3770

Query: 793  SSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRS 852
             S   ++  +     SH S  +S  +   DAS  +   +S S+ +  EE+   GS HS S
Sbjct: 3771 GSYHEQSVDRSGHSGSHHSHTTS--QGRSDASHGQSGSRSASRETRNEEQSGDGSRHSGS 3828

Query: 853  R-------------SRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSD 899
            R             S+SG+  S+   SRRS    S  S D    S   +Y +DS      
Sbjct: 3829 RHHEASTQADSSRHSQSGQGESA--GSRRSRRQGSSVSQD----SDSEAYPEDSERRSES 3882

Query: 900  RSRRH--SKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSR 957
             SR H  S R    D S +  S HR       SS      S ++      S +++ +   
Sbjct: 3883 ASRNHHGSSREQSRDGSRHPGSSHRDTASHVQSSPVQSDSSTAKEHGHFSSLSQDSAYHS 3942

Query: 958  G-RSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWG---HE 1013
            G +SR S  S S    +S  T     Q    +      S       SG R    G   + 
Sbjct: 3943 GIQSRGSPHSSSSYHYQSEGTERQKGQSGLVWRHGSYGSADYDYGESGFRHSQHGSVSYN 4002

Query: 1014 SPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPG 1048
            S       R D  ++  +    P Y+ +   + PG
Sbjct: 4003 SNPVVFKERSDICKASAFGKDHPRYYATYINKDPG 4037



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 93/435 (21%), Positives = 166/435 (38%), Gaps = 57/435 (13%)

Query: 671  KSHRHKKKKKHKKSSKHK-RKHKADTEEKSSKAESGEKSKKR-----KKRKRKKNKSSAP 724
            +++    +K++   S HK RKH    + + +K E  ++++KR     ++  RK NK  + 
Sbjct: 83   QAYYESTRKENLPISGHKHRKHSHHDKHEDNKQEENKENRKRPSSLERRNNRKGNKGRSK 142

Query: 725  ADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGR 784
            +  E G K     S      ++ R+    + R     +   +  K E     +++    R
Sbjct: 143  SPRETGGKRHESSS-----EKKERKGYSPTHREEEYGKNHHNSSKKEKNKTENTRLGDNR 197

Query: 785  KHKGELPPSSCQRRAG----------TKRSSRSSHRSQPSSGDEDSDDASSHRLHQ---- 830
            K   E          G          T++  +S H +   +  +++ D +   L +    
Sbjct: 198  KRLSERLEEKEDNEEGVYDYENTGRMTQKWIQSGHIATYYTIQDEAYDTTDSLLEENKIY 257

Query: 831  --------KSPSQYSEEEEEEDS--GSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQ 880
                    KS SQ +    E  S    + SR+R R G R S  R S   +S  S+  S  
Sbjct: 258  ERSRSSDGKSSSQVNRSRHENTSQVPLQESRTRKRRGSRVSQDRDS-EGHSEDSERHSG- 315

Query: 881  SCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCS 940
               S  R++   ++    D SR    RSHD D + +  S   S++     ++       +
Sbjct: 316  ---SASRNHHGSAWEQSRDGSRH--PRSHDEDRASHGHSADSSRQSGTRHAETSSRGQTA 370

Query: 941  QSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPS 1000
             S  ++RS   ER  S G  +S+  SR  +  R ++++A S +  R  S  ++  +   S
Sbjct: 371  SSHEQARSSPGERHGS-GHQQSADSSRHSATGRGQASSAVSDRGHRGSSGSQASDSEGHS 429

Query: 1001 QRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKA 1060
            + S ++  S GH     R    ++  R +              GE  G+        S  
Sbjct: 430  ENSDTQSVS-GHGKAGLRQQSHQESTRGR-------------SGERSGRSGSSLYQVSTH 475

Query: 1061 TGPPSQNSNIGTGRG 1075
              P S +   GT  G
Sbjct: 476  EQPDSAHGRTGTSTG 490


>gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo
            sapiens]
          Length = 434

 Score = 95.9 bits (237), Expect = 3e-19
 Identities = 80/241 (33%), Positives = 112/241 (46%), Gaps = 29/241 (12%)

Query: 802  KRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEH-SRSRSRSGRRH 860
            +++S    + +  S    S  AS H   +        + + ++ G +H SRSRS+ GRRH
Sbjct: 14   EKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRH 73

Query: 861  -SSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASS 919
             S  +SS++  S   +     S   R+R  S ++  D   R  R S R        ++ S
Sbjct: 74   ESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGR-----SHSRS 128

Query: 920  KHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTA 979
            + R +RH+          S S+ R +SRS +RER +SR RSR    SRSRS+ R R   +
Sbjct: 129  RSRERRHR----------SRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRS 178

Query: 980  HSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYF 1039
             S  RSR   R RSRS      RS SR R    E P       R F RS + R+ SP  F
Sbjct: 179  RSRSRSRHRHRTRSRS----RTRSRSRDRKKRIEKP-------RRFSRS-LSRTPSPPPF 226

Query: 1040 R 1040
            R
Sbjct: 227  R 227



 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 77/290 (26%), Positives = 123/290 (42%), Gaps = 34/290 (11%)

Query: 723  APADSER-GPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDH 781
            A +D+ER G  PE       +P R +++ Q +       ++   S  +          D+
Sbjct: 2    AASDTERDGLAPE-----KTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDN 56

Query: 782  GGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLH--QKSPSQYSEE 839
             GRKH+     S   RR  +K  S   H+S+  +  E S D    RL+  +    ++  +
Sbjct: 57   EGRKHRSR-SRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRK 115

Query: 840  EEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSD 899
            E +   G  HSRSRSR  R  S  R  ++S S S +    +S  SR+R     S S   +
Sbjct: 116  ERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRS-RSRERK---KSRSRSRE 171

Query: 900  RSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGR 959
            R RR   RS        + S+HR +               S+SR+RSRS  R++   + R
Sbjct: 172  RKRRIRSRSR-------SRSRHRHRTR-------------SRSRTRSRSRDRKKRIEKPR 211

Query: 960  SRSSSCSRSRSKRRSRS-TTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKR 1008
              S S SR+ S    R   TA   Q + +   +R++  +   ++    K+
Sbjct: 212  RFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQ 261



 Score = 51.2 bits (121), Expect = 7e-06
 Identities = 57/233 (24%), Positives = 86/233 (36%), Gaps = 26/233 (11%)

Query: 652 GSETEDTGRSLPSKKERSGKSHRHKKKKKH---KKSSKHKRKHKADTEEKSSKAESGEKS 708
           G   E T      KKE+S  S   +  K H    +S   +RK K+D E +  ++ S  K 
Sbjct: 10  GLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKE 69

Query: 709 KKR---KKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGS 765
            +R   K +  KK+KS    D E           S    R R  + ++ + R    E  S
Sbjct: 70  GRRHESKDKSSKKHKSEEHNDKEH----------SSDKGRERLNSSENGEDRHKRKERKS 119

Query: 766 SGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASS 825
           S  +      S  + H  R  + +   S  + R  ++  SR   +S+  S +        
Sbjct: 120 SRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRER------K 173

Query: 826 HRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASS 878
            R+  +S S+              SR+RSRS  R       RR   S S   S
Sbjct: 174 RRIRSRSRSRSRHRHRTRS----RSRTRSRSRDRKKRIEKPRRFSRSLSRTPS 222



 Score = 47.8 bits (112), Expect = 8e-05
 Identities = 38/191 (19%), Positives = 70/191 (36%), Gaps = 9/191 (4%)

Query: 647 PGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGE 706
           P  S    +    RS   K++   +  +H+ + + K+  +H+ K K+  + KS +    E
Sbjct: 33  PRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHESKDKSSKKHKSEEHNDKE 92

Query: 707 KSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSS 766
            S   K R+R  +  +     +R  +    G        R RR +  S+ R         
Sbjct: 93  HSSD-KGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRE 151

Query: 767 GKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSH 826
            KK        S+     + K        +RR  ++  SRS HR +  S       +   
Sbjct: 152 RKK--------SRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHRTRSRSRTRSRSRDR 203

Query: 827 RLHQKSPSQYS 837
           +   + P ++S
Sbjct: 204 KKRIEKPRRFS 214



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 39/184 (21%), Positives = 72/184 (39%), Gaps = 25/184 (13%)

Query: 577 KLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASG 636
           K  R  +++ K ++K K    + K+H           S + G E++  S  G        
Sbjct: 68  KEGRRHESKDKSSKKHKSEEHNDKEH-----------SSDKGRERLNSSENGEDRHKRKE 116

Query: 637 SACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTE 696
                  K   G SH        R     +ER     R +++KK +  S+ ++K ++ + 
Sbjct: 117 ------RKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSR 170

Query: 697 EKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPG------SGSPAPP--RRRR 748
           E+  +  S  +S+ R + + +    +     +R  + E P       S +P+PP  R R 
Sbjct: 171 ERKRRIRSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRN 230

Query: 749 RAQD 752
            A D
Sbjct: 231 TAMD 234



 Score = 36.2 bits (82), Expect = 0.25
 Identities = 43/161 (26%), Positives = 61/161 (37%), Gaps = 13/161 (8%)

Query: 910  DSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSR-SRSHTRERSRSR-----GRSRSS 963
            D++    A  K    R K      + S+S   S+   SRS +R R R R     GR   S
Sbjct: 5    DTERDGLAPEKTSPDRDK-KKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRS 63

Query: 964  SCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGR- 1022
              SRS+  RR  S    S +       D+  S+    +R  S +        +ER S R 
Sbjct: 64   R-SRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRG 122

Query: 1023 ----RDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSK 1059
                R   R + +RS+S    +S       KK   R  + K
Sbjct: 123  RSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERK 163


>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
          Length = 1007

 Score = 94.7 bits (234), Expect = 6e-19
 Identities = 130/489 (26%), Positives = 197/489 (40%), Gaps = 84/489 (17%)

Query: 644  KQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAE 703
            + E   S  S  E+ G      +++S   H   KKKKHK  SKHK KHK  +EE   K  
Sbjct: 14   EMEDANSEKSINEENGEV---SEDQSQNKHSRHKKKKHKHRSKHK-KHKHSSEEDKDK-- 67

Query: 704  SGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQD-------DSQR 756
               K K + K K+ K K    A  + G             P +R +  D       + QR
Sbjct: 68   ---KHKHKHKHKKHKRKEIIDASDKEG-----------MSPAKRTKLDDLALLEDLEKQR 113

Query: 757  RSLPAE---EGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSH-RSQ 812
              + AE   E   GK   G G        G + +GE+   +   R G + S+RSS  + +
Sbjct: 114  ALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKA---RNGNRSSTRSSSTKGK 170

Query: 813  PSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSE---HSRSRSRSGRRHSSHRSSRRS 869
                D         +   K  +++  ++++   G E      +RS+S  R  S   S+RS
Sbjct: 171  LELVDNKITTKKRSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRS 230

Query: 870  YSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYS 929
              S   A   +S   R+RS              +  K    +DD      K +SK  K S
Sbjct: 231  -KSQDQARKSKSPTLRRRS------------QEKIGKARSPTDDKVKIEDKSKSKDRKKS 277

Query: 930  SSDDDYSLSCSQSRSRSRSHTRERSRS----RGRSRSSSCSRSRSKRRSRSTTAHSWQRS 985
                      ++SRSR R    ++SRS    RG+S+    SRS+ ++  RS T    +  
Sbjct: 278  P-------IINESRSRDRG---KKSRSPVDLRGKSKDRR-SRSKERKSKRSETDKEKKPI 326

Query: 986  RSYSRDRS--RSTRSPSQRSG--SRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRS 1041
            +S S+D S  +  RSPS+R G   ++RS    SP+ R   RR   RS +   +     +S
Sbjct: 327  KSPSKDASSGKENRSPSRRPGRSPKRRSL---SPKPRDKSRRS--RSPLLNDRRSKQSKS 381

Query: 1042 -GRGEGPGKKDDGRGDDSKATGPPSQ---------NSNIGTGRGSEGDCSPEDKNSVTAK 1091
              R   PG++   R  + K   P  +           +I + R    D SP ++ S T +
Sbjct: 382  PSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRR 441

Query: 1092 LLLEKIQSR 1100
                 I+ R
Sbjct: 442  RSRSPIRRR 450



 Score = 88.2 bits (217), Expect = 5e-17
 Identities = 118/419 (28%), Positives = 167/419 (39%), Gaps = 47/419 (11%)

Query: 636  GSACSGLNKQEPGGSHGSETE--------DTGRSLPSKKERSGK----SHRHKKKKKHKK 683
            G   SG+     G   GSE E        +  RS        GK     ++   KK+ K 
Sbjct: 127  GKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKS 186

Query: 684  SSKHKRKHKADTEEKSSKAES-GEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPA 742
             SK + +H++D ++     E   EK+ + K ++RKK+KS +     +  K +     S +
Sbjct: 187  RSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPS-----KRSKSQDQARKSKS 241

Query: 743  PPRRRRRAQDDSQRRSLPAE----EGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRR 798
            P  RRR  +   + RS   +    E  S  KD       ++     + K    P   + +
Sbjct: 242  PTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGK 301

Query: 799  AGTKRSSRSSHRSQPSSGDED-------SDDASSHRLHQKSPSQYSEEEEEEDSGSEHSR 851
            +  +RS     +S+ S  D++       S DASS +   +SPS+      +  S S   R
Sbjct: 302  SKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGK-ENRSPSRRPGRSPKRRSLSPKPR 360

Query: 852  SRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDS 911
             +SR  R  S   + RRS  S S  S   S   R +S S +      +R R  S R+   
Sbjct: 361  DKSRRSR--SPLLNDRRSKQSKSP-SRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPR 417

Query: 912  DDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRS- 970
            DD    S + RSK       D       S +R RSRS  R RSRS  R   S   RSRS 
Sbjct: 418  DD--ILSRRERSK-------DASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSP 468

Query: 971  KRRSRSTTAHSWQRSRSYS----RDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDF 1025
            +RR R   + S  R RS S    R RSRS     +  GS       E          DF
Sbjct: 469  RRRDRGRRSRSRLRRRSRSRGGRRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLEDF 527



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 93/435 (21%), Positives = 152/435 (34%), Gaps = 29/435 (6%)

Query: 750  AQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSH 809
            A+  S R     E+ +S K      G  S+D    KH          R    K   RS H
Sbjct: 4    AETQSLREQPEMEDANSEKSINEENGEVSEDQSQNKH---------SRHKKKKHKHRSKH 54

Query: 810  RSQPSSGDEDSDDASSHR-LHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRR 868
            +    S +ED D    H+  H+K   +   +  +++  S   R++             R 
Sbjct: 55   KKHKHSSEEDKDKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRA 114

Query: 869  SYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKY 928
               +  D    +             Y   S+      +++ + + S   SS  + K    
Sbjct: 115  LIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELV 174

Query: 929  SSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSR--SSSCSRSRSKRRSRSTTAHSWQRSR 986
             +       S S+S+ R+R H  ++ +S+G         +RS+SK R +S +       R
Sbjct: 175  DNKITTKKRSKSRSKERTR-HRSDKKKSKGGIEIVKEKTTRSKSKERKKSKS----PSKR 229

Query: 987  SYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEG 1046
            S S+D++R ++SP+ R  S+++     SP +      D  +SK  R +SP      R   
Sbjct: 230  SKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKIEDKSKSK-DRKKSP-IINESRSRD 287

Query: 1047 PGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKP 1106
             GKK     D     G      +    R S+   S  DK     K   +   S K  R P
Sbjct: 288  RGKKSRSPVD---LRGKSKDRRSRSKERKSKR--SETDKEKKPIKSPSKDASSGKENRSP 342

Query: 1107 SVSEEVQATPNKAGPKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNKKCEESGL 1166
            S             PK +D  +    P L      +   P       T  P ++ +   L
Sbjct: 343  SRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSP-----SRTLSPGRRAKSRSL 397

Query: 1167 ERGEEQEQSETEEGP 1181
            ER   + +      P
Sbjct: 398  ERKRREPERRRLSSP 412



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 105/509 (20%), Positives = 189/509 (37%), Gaps = 56/509 (11%)

Query: 418 EQMDGDNTTHPKNAPESKKGS---SPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPS 474
           E +D   TT  ++   SK+ +   S K KS  K       EKT    S++ K+       
Sbjct: 172 ELVDNKITTKKRSKSRSKERTRHRSDKKKS--KGGIEIVKEKTTRSKSKERKK------- 222

Query: 475 EPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQEGPKHPT 534
              SK+ +K++   D + +S     ++ S+ ++ ++ S  +  +      +S++  K P 
Sbjct: 223 ---SKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPI 279

Query: 535 GPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTKGTEKPKD 594
                  S+D     + P +L   +K   S S               K  R++  ++ K 
Sbjct: 280 --INESRSRDRGKKSRSPVDLRGKSKDRRSRS------------KERKSKRSETDKEKKP 325

Query: 595 IGSSSKDHLQGLD-------PGEPNKSKEVGG---EKIVRSSGGRMDAPASGSACSGLNK 644
           I S SKD   G +       PG   K + +     +K  RS    ++   S  + S    
Sbjct: 326 IKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSRT 385

Query: 645 QEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAES 704
             PG    S + +  R  P ++  S      + + +    S+ +R   A    + S    
Sbjct: 386 LSPGRRAKSRSLERKRREPERRRLSSP----RTRPRDDILSRRERSKDASPINRWSPTRR 441

Query: 705 GEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLP--AE 762
             +S  R++ +    +S +P    R P+    G  S +  RRR R++   +RRS     E
Sbjct: 442 RSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKVKE 501

Query: 763 EGSSGKKDEG---GGGSSSQDH------GGRKHKGELPPSSCQRRAGTKRSSRSSHRSQP 813
           +   G   EG      SSS D+           +  +     QR+A  ++    +  S  
Sbjct: 502 DKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQRQAIVQKYKYLAEDSNM 561

Query: 814 SSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSS 873
           S   E S   SS R    SP    E    +    E+ R    +       + +  +   +
Sbjct: 562 SVPSEPSSPQSSTRTRSPSPDDILERVAAD--VKEYERENVDTFEASVKAKHNLMTVEQN 619

Query: 874 SDASSDQSCYSRQRSYSDDSYSDYSDRSR 902
           + +S  +       + SDD ++ Y D +R
Sbjct: 620 NGSSQKKLLAPDMFTESDDMFAAYFDSAR 648


>gi|153251865 hypothetical protein LOC84226 [Homo sapiens]
          Length = 1984

 Score = 94.7 bits (234), Expect = 6e-19
 Identities = 100/379 (26%), Positives = 144/379 (37%), Gaps = 34/379 (8%)

Query: 660  RSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEE--KSSKAESGEKSKKRKKRKRK 717
            RS   + +RS    RH    +    S  ++ H + +E   +S    +     +R      
Sbjct: 1567 RSPSERSQRSSLERRHHSPSQRSHCSPSRKNHSSPSERSWRSPSQRNHCSPPERSCHSLS 1626

Query: 718  KNKSSAPAD-SERGP---KPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGG 773
            +    +P+  S RGP   +   P   S   P  R       +R   P++    G  +   
Sbjct: 1627 ERGLHSPSQRSHRGPSQRRHHSPSERSHRSPSERSHRSSSERRHRSPSQRSHRGPSERSH 1686

Query: 774  GGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSP 833
               S + H     +    PS  +  + +KRS RS  R    S  E S  + S R H  SP
Sbjct: 1687 CSPSERRHRSPSQRSHRGPSERRHHSPSKRSHRSPARRSHRSPSERSHHSPSERSHH-SP 1745

Query: 834  SQ---YSEEEEEEDSGSEHS-------RSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCY 883
            S+   +S  E    S SE S       R RS S RRH  H  S +S+ S S+ S      
Sbjct: 1746 SERRHHSPSERSHCSPSERSHCSPSERRHRSPSERRH--HSPSEKSHHSPSERSHHSPSE 1803

Query: 884  SRQRSYSDDSYSDYSDRSRR--HSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQ 941
             R+ S  + S     +RS R    +RSH S    +  S  R     +S S+  +     +
Sbjct: 1804 RRRHSPLERSRHSLLERSHRSPSERRSHRS----FERSHRRISERSHSPSEKSHLSPLER 1859

Query: 942  SRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRS--RSYSRDRSRSTRSP 999
            SR          S  RG S S     S S+R  RS +     R+  RS+     R+  SP
Sbjct: 1860 SRC-------SPSERRGHSSSGKTCHSPSERSHRSPSGMRQGRTSERSHRSSCERTRHSP 1912

Query: 1000 SQRSGSRKRSWGHESPEER 1018
            S+    R     H SP ER
Sbjct: 1913 SEMRPGRPSGRNHCSPSER 1931



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 115/432 (26%), Positives = 167/432 (38%), Gaps = 40/432 (9%)

Query: 698  KSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRR---RRAQD-- 752
            ++ + +S  +SKK   R    ++ S    S  G + +  G   P  P +R   R  +D  
Sbjct: 1476 RTVQKDSSSRSKKNFYRNETSSQESKNL-STPGTRVQARGRILPGSPVKRTWHRHLKDKL 1534

Query: 753  ---DSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSH 809
               +    S   E    G  +      S ++H     + +      +  + ++RS  S  
Sbjct: 1535 THKEHNHPSFYRERTPRGPSERTRHNPSWRNHRSPSERSQRSSLERRHHSPSQRSHCSPS 1594

Query: 810  RSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRS-RSRSGRRHSSHRSSRR 868
            R   SS  E S  + S R H   P +      E    S   RS R  S RRH  H  S R
Sbjct: 1595 RKNHSSPSERSWRSPSQRNHCSPPERSCHSLSERGLHSPSQRSHRGPSQRRH--HSPSER 1652

Query: 869  SYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRS---KR 925
            S+ S S+ S   S   R RS S  S+       R  S+RSH S     +  +HRS   + 
Sbjct: 1653 SHRSPSERSHRSSSERRHRSPSQRSH-------RGPSERSHCSP----SERRHRSPSQRS 1701

Query: 926  HKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRR--SRSTTAHSWQ 983
            H+  S    +S S    RS +R   R  S     S S     S S+RR  S S  +H   
Sbjct: 1702 HRGPSERRHHSPSKRSHRSPARRSHRSPSERSHHSPSERSHHSPSERRHHSPSERSHCSP 1761

Query: 984  RSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEER--HSGRRDFIRSKIYRSQSPHYFRS 1041
              RS+     R  RSPS+R         H SP ER  HS       S + RS+     RS
Sbjct: 1762 SERSHCSPSERRHRSPSERRHHSPSEKSHHSPSERSHHSPSERRRHSPLERSRHSLLERS 1821

Query: 1042 GRGEGPGKKDDGRGDD------SKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLE 1095
             R   P ++   R  +      S+ +  PS+ S++     S   CSP ++   ++     
Sbjct: 1822 HR--SPSERRSHRSFERSHRRISERSHSPSEKSHLSPLERSR--CSPSERRGHSSSGKTC 1877

Query: 1096 KIQSRKVERKPS 1107
               S +  R PS
Sbjct: 1878 HSPSERSHRSPS 1889



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 135/586 (23%), Positives = 211/586 (36%), Gaps = 75/586 (12%)

Query: 452  QGAEKTVSEVSEQPKETSMTEPSEPGSKAEAKKA-LGGDVSDQSLESHSQKVSETQMCES 510
            + A++     S QP+   + +P++  S    + A +G  +     +S S+        E+
Sbjct: 1436 RSAQQPRRAYSFQPRPLRLPKPTDSQSGIAFQTASVGQPLRTVQKDSSSRSKKNFYRNET 1495

Query: 511  NSSKETSLATPAGKESQEG---PKHPTGPFFPVLSKDESTALQW--PSELLIFTKAEPSI 565
            +S +  +L+TP  +    G   P  P    +    KD+ T  +   PS     T   PS 
Sbjct: 1496 SSQESKNLSTPGTRVQARGRILPGSPVKRTWHRHLKDKLTHKEHNHPSFYRERTPRGPSE 1555

Query: 566  SYSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRS 625
                NP + + +    +  R+  + + +    S + H     P   N S     E+  RS
Sbjct: 1556 RTRHNPSWRNHRSPSERSQRS--SLERRHHSPSQRSHCS---PSRKNHSSP--SERSWRS 1608

Query: 626  SGGRMDAPASGSACSGLNKQEPGGSHG-SETEDTGRSLPSKKERSGKSHRHKKKKKHKKS 684
               R        +C  L+++   G H  S+    G S       S +SHR   ++ H+ S
Sbjct: 1609 PSQRNHCSPPERSCHSLSER---GLHSPSQRSHRGPSQRRHHSPSERSHRSPSERSHRSS 1665

Query: 685  SKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPP 744
            S+  R+H++ ++               ++R R  ++ S    SER  +   P   S   P
Sbjct: 1666 SE--RRHRSPSQRSHRGPSERSHCSPSERRHRSPSQRSHRGPSER--RHHSPSKRSHRSP 1721

Query: 745  RRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRS 804
             RR       +    P+E       +      S + H     +    PS  + R+ ++R 
Sbjct: 1722 ARRSHRSPSERSHHSPSERSHHSPSERRHHSPSERSHCSPSERSHCSPSERRHRSPSERR 1781

Query: 805  SRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSR-SRSRSGRRHSSH 863
              S     PS     S    SH         +S  E    S  E SR S      R  S 
Sbjct: 1782 HHS-----PSEKSHHSPSERSH---------HSPSERRRHSPLERSRHSLLERSHRSPSE 1827

Query: 864  RSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRS 923
            R S RS+  S                            RR S+RSH   +  + S   RS
Sbjct: 1828 RRSHRSFERS---------------------------HRRISERSHSPSEKSHLSPLERS 1860

Query: 924  K----RHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTA 979
            +      +  SS      S S+   RS S  R+  R+  RS  SSC R+   R S S   
Sbjct: 1861 RCSPSERRGHSSSGKTCHSPSERSHRSPSGMRQ-GRTSERSHRSSCERT---RHSPSEMR 1916

Query: 980  HSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDF 1025
                  R++     RS RSP +     K S+  E P   HS  RDF
Sbjct: 1917 PGRPSGRNHCSPSERSRRSPLKE--GLKYSFPGERPS--HSLSRDF 1958



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 63/233 (27%), Positives = 93/233 (39%), Gaps = 35/233 (15%)

Query: 898  SDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRS- 956
            S+R+R +    +    S+ +      +RH +S S   +   CS SR   ++H+    RS 
Sbjct: 1554 SERTRHNPSWRNHRSPSERSQRSSLERRH-HSPSQRSH---CSPSR---KNHSSPSERSW 1606

Query: 957  RGRSRSSSCS------RSRSKR--RSRSTTAHSWQRSRSYSRDRSRSTRSPSQRS---GS 1005
            R  S+ + CS       S S+R   S S  +H     R +     RS RSPS+RS    S
Sbjct: 1607 RSPSQRNHCSPPERSCHSLSERGLHSPSQRSHRGPSQRRHHSPSERSHRSPSERSHRSSS 1666

Query: 1006 RKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPS 1065
             +R   H SP +R S R    RS    S+  H   S R          RG   +    PS
Sbjct: 1667 ERR---HRSPSQR-SHRGPSERSHCSPSERRHRSPSQRSH--------RGPSERRHHSPS 1714

Query: 1066 QNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPNK 1118
            + S+    R S    S    +S + +       S    R  S SE    +P++
Sbjct: 1715 KRSHRSPARRSHRSPSERSHHSPSER----SHHSPSERRHHSPSERSHCSPSE 1763


>gi|57864582 hornerin [Homo sapiens]
          Length = 2850

 Score = 91.7 bits (226), Expect = 5e-18
 Identities = 131/499 (26%), Positives = 170/499 (34%), Gaps = 50/499 (10%)

Query: 619  GEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDT-GRSLPSKKERSGKSH-RHK 676
            G +  +SS G     +SGS+ S        G HGS +  + G        R   SH RH 
Sbjct: 261  GSRSGQSSRGERHRSSSGSSSSY-------GQHGSGSRQSLGHGRQGSGSRQSPSHVRHG 313

Query: 677  KKKKHKKS-----SKHKRKHKADTEEKSSKAESG---EKSKKRKKRKRKKNKSSAPADSE 728
                H  S     S     +     E  S   SG    +S   +     K+ S +   S 
Sbjct: 314  SGSGHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQSSGYSKHGSGSGHSSS 373

Query: 729  RGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKG 788
            +G      G  S +        Q  S  +   A   SSG+     G   S  HG R    
Sbjct: 374  QGQHGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSSGRGQHSSGSGQSPGHGQRGSGS 433

Query: 789  ELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDA-SSHRLHQKSPSQYSEEEEEEDSGS 847
               PSS Q   G  RSS        SSG   S    SS   H +S S++S    +  SGS
Sbjct: 434  GQSPSSGQHGTGFGRSS--------SSGPYVSGSGYSSGFGHHESSSEHSSGYTQHGSGS 485

Query: 848  EHS---------RSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYS 898
             HS           +S  G R  S   S  SY      S     +SR  S S  S S   
Sbjct: 486  GHSSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQHGSGSRQSLGHSRHGSGSGQSPSPSR 545

Query: 899  DRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRG 958
             R    S++S       Y S +  S+    S S     L   +SRS   S   +   S G
Sbjct: 546  GRHESGSRQSSSYGPHGYGSGRSSSRGPYESGSGHSSGLGHQESRSGQSSGYGQHGSSSG 605

Query: 959  RSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEER 1018
             S S+      +  +S S   H     +S S  +  S  S S R G +    G      R
Sbjct: 606  HS-STHGQHGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSPSRGR 664

Query: 1019 HSGRRDFIRSKIY----------RSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNS 1068
            H    DF  S  Y           S  PH   SG+  G G K  G G  S  +   S +S
Sbjct: 665  HGS--DFGHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHK-SGSGQSSGYSQHGSGSS 721

Query: 1069 NIGTGRGSEGDCSPEDKNS 1087
            +  +G    G  S +   S
Sbjct: 722  H-SSGYRKHGSRSGQSSRS 739



 Score = 91.7 bits (226), Expect = 5e-18
 Identities = 132/521 (25%), Positives = 178/521 (34%), Gaps = 51/521 (9%)

Query: 596  GSSSKDHLQGLDPGEPNK-------SKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPG 648
            G SS+   QG   G  +        S++  G     S  G+  +P+ G   SG  +    
Sbjct: 499  GQSSRGERQGSSAGSSSSYGQHGSGSRQSLGHSRHGSGSGQSPSPSRGRHESGSRQSSSY 558

Query: 649  GSHGSETEDTGRSLPSKKERSGKSHR----HKKKK--------KHKKSSKHKRKHKADTE 696
            G HG     +GRS       SG  H     H++ +        +H  SS H   H     
Sbjct: 559  GPHGY---GSGRSSSRGPYESGSGHSSGLGHQESRSGQSSGYGQHGSSSGHSSTHGQHGS 615

Query: 697  EKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQR 756
                 +  G+      +        S  + S R  +    GSGS   P R R   D    
Sbjct: 616  TSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQQ---GSGSGQSPSRGRHGSDFGHS 672

Query: 757  RSLPAEEGSSG-KKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSS 815
             S       SG     G  GS S    G  HK     SS   + G+  S  S +R   S 
Sbjct: 673  SSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGYRKHGSR 732

Query: 816  GDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSD 875
              +     SS      S S  S    +  SGS  S    R G   S H  SR  + SSS 
Sbjct: 733  SGQ-----SSRSEQHGSSSGLSSSYGQHGSGSHQSSGHGRQGSG-SGHSPSRVRHGSSSG 786

Query: 876  ASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDY 935
             SS    +    S S  S   Y   S + S        S    S+H S    +SS     
Sbjct: 787  HSSSHGQHGSGTSCSS-SCGHYESGSGQASGFGQHESGSGQGYSQHGSASGHFSSQGRHG 845

Query: 936  SLSCSQSRSRSRSHTRERSRSRGRSRSSS---CSRSRSKRRSRSTTAHSWQ-----RSRS 987
            S S   S S     +  +S S G+  S+S     R R    S  +  H  +     +S S
Sbjct: 846  STSGQSSSSGQHDSSSGQSSSYGQHESASHHASGRGRHGSGSGQSPGHGQRGSGSGQSPS 905

Query: 988  YSRDRSRSTRSPSQ-RSGS---RKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGR 1043
            Y R  S S RS S  R GS   +   +GH+S   + SG   + +       S  Y + G 
Sbjct: 906  YGRHGSGSGRSSSSGRHGSGSGQSSGFGHKSSSGQSSG---YTQHGSGSGHSSSYEQHGS 962

Query: 1044 GEGPGKKDDGRGDDSKAT---GPPSQNSNIGTGRGSEGDCS 1081
              G   + +  G  S ++   G     S    G G  G  S
Sbjct: 963  RSGQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGS 1003



 Score = 84.3 bits (207), Expect = 8e-16
 Identities = 133/540 (24%), Positives = 181/540 (33%), Gaps = 100/540 (18%)

Query: 624  RSSGGRMDAPASGSACSGLNKQEPGGSHGS---ETEDTGRSLPSKKE------------- 667
            R SG R  +P+ G   SG  +    G HGS   E+   G    S  +             
Sbjct: 1131 RGSGSRQ-SPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGH 1189

Query: 668  ---------RSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRK- 717
                     RSG+S R ++      SS H  +H + + + S     G  S     R R  
Sbjct: 1190 SSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHG 1249

Query: 718  ----------KNKSSAPADSERGPKPEPPG----------------------SGSPAPPR 745
                      ++ S +   S RGP     G                      SGS     
Sbjct: 1250 SGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCS 1309

Query: 746  RRRRAQDDSQRRSLPAEEGSSGKKDEGG--GGSSSQDHGGRKHKGELPPSSCQRRAGTKR 803
            + +      Q  +   E  S+G+    G  G  SSQ  G  +H      S  + R G+  
Sbjct: 1310 QGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSSQSSGYGRHGAGSGQSPSRGRHGSG- 1368

Query: 804  SSRSSHRSQPSSGDEDSDDASSHRL---------HQKSPSQYSEEEEEEDSGSEHSRSRS 854
            S  SS   Q  SG   S  +  H           H +S S  S    +  SGS HS S  
Sbjct: 1369 SGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGCTQHGSGSGHSSSYE 1428

Query: 855  RSGRRHS-SHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDD 913
            + G R   S R  R   SS S +S  Q     ++S     +   S +S   S+  H S  
Sbjct: 1429 QHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGS 1488

Query: 914  SDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRR 973
               +S         +SSS   Y    S S       +R    S      SS   S +  +
Sbjct: 1489 GQSSSYSPYGSGSGWSSSRGPYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQ 1548

Query: 974  SRSTTAHSWQ-----RSRSYSRDRSRSTRSPSQRSG-SRKRSWGHESP--EERHSGRRDF 1025
              ST+  S        S   S    +     SQ SG  R+ S   +SP   +R SG R  
Sbjct: 1549 HGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSR-- 1606

Query: 1026 IRSKIYRSQSPHYFRSGRGEG----PGKKDDGRGDDS------KATGPPSQNSNIGTGRG 1075
                    QSP Y R G G G     G+   G G+ S       ++G  S  S  G+G G
Sbjct: 1607 --------QSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSG 1658



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 122/487 (25%), Positives = 162/487 (33%), Gaps = 41/487 (8%)

Query: 598  SSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETED 657
            SS    QG   G        G      SS G+  +  S S+  G  +   G + G    +
Sbjct: 762  SSGHGRQGSGSGHSPSRVRHGSSSGHSSSHGQHGSGTSCSSSCGHYESGSGQASGFGQHE 821

Query: 658  TGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRK 717
            +G      +  S   H   + +    S +     + D+    S +    +S       R 
Sbjct: 822  SGSGQGYSQHGSASGHFSSQGRHGSTSGQSSSSGQHDSSSGQSSSYGQHESASHHASGRG 881

Query: 718  KNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGG--G 775
            ++ S +      G +    GSGS   P   R     S R S     GS   +  G G   
Sbjct: 882  RHGSGSGQSPGHGQR----GSGSGQSPSYGRHGSG-SGRSSSSGRHGSGSGQSSGFGHKS 936

Query: 776  SSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQ 835
            SS Q  G  +H      SS   + G+ RS +SS   Q  S    S     H     S S+
Sbjct: 937  SSGQSSGYTQHGSGSGHSSSYEQHGS-RSGQSSRSEQHGSSSGSSSSYGQHG----SGSR 991

Query: 836  YSEEEEEEDSGSEHSRSRSRSGRRHSS---HRSSRRSYSSSSDASSDQSCYSRQRSYSDD 892
             S    +  SGS  S S SR   RH S     SS   Y S S  SS +  Y     +S  
Sbjct: 992  QSLGHGQHGSGSGQSPSPSRG--RHGSGSGQSSSYGPYRSGSGWSSSRGPYESGSGHS-- 1047

Query: 893  SYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRE 952
                 S    R S+    S    + SS   S  H    S    S SC Q  + S   +  
Sbjct: 1048 -----SGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSH 1102

Query: 953  RSRSRGRSRSSSCSRSRS---KRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRS 1009
                 G S+SS   R  S   +           ++S SY R  S S RS S  SG     
Sbjct: 1103 GQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSS--SGQHGSG 1160

Query: 1010 WGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSN 1069
             G  S    H              QS  Y + G G G      G G     +G  S+   
Sbjct: 1161 LGESSGFGHHESS---------SGQSSSYSQHGSGSG---HSSGYGQHGSRSGQSSRGER 1208

Query: 1070 IGTGRGS 1076
             G+  GS
Sbjct: 1209 HGSSSGS 1215



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 139/567 (24%), Positives = 187/567 (32%), Gaps = 94/567 (16%)

Query: 596  GSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDA-----PASGSACSGLNKQEPGGS 650
            G SS+    G   G  +   + G      S  GR  +     P+ G   SGL      G 
Sbjct: 1201 GQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGLGHSSSHGQ 1260

Query: 651  HGSET----------EDTGRSLPSKKERSGKSHRHKKKKKHKKSSKH---KRKHKADTEE 697
            HGS +            +G S    +  SG  H      +H   S H   + +H + + +
Sbjct: 1261 HGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHS-SAYSQHGSGSGHFCSQGQHGSTSGQ 1319

Query: 698  KSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRR 757
             S+  + G  + +      + + SS  +   R       G+GS   P R R         
Sbjct: 1320 SSTFDQEGSSTGQSSSYGHRGSGSSQSSGYGRH------GAGSGQSPSRGRHGSGSGHSS 1373

Query: 758  SLPAEEGSSGKKDEGG--GGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRS---- 811
            S       SG     G  G  S Q  G   H+     SS Q    T+  S S H S    
Sbjct: 1374 SYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHES----SSWQSSGCTQHGSGSGHSSSYEQ 1429

Query: 812  ------QPSSGDE---DSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSS 862
                  Q S G+     S  +SS+  H  S S+ S    +  SGS  S S SR      S
Sbjct: 1430 HGSRSGQSSRGERHGSSSGSSSSYGQHG-SGSRQSLGHGQHGSGSGQSPSPSRGRHGSGS 1488

Query: 863  HRSSRRS-YSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKH 921
             +SS  S Y S S  SS +  Y    S+S       S    R S+    S    + SS  
Sbjct: 1489 GQSSSYSPYGSGSGWSSSRGPYESGSSHS-------SGLGHRESRSGQSSGYGQHGSSSG 1541

Query: 922  RSKRHKYSSSDDDYSLSCSQ---SRSRSRSHTRE---RSRSRGRSRSSSCS--------R 967
             S  H    S    S SC Q   S  +S SH +     S+S G  R  S S        R
Sbjct: 1542 HSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQR 1601

Query: 968  SRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHS------- 1020
                R+S S   H     RS S  +  S    S   G  + S G  S   +H        
Sbjct: 1602 GSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSS 1661

Query: 1021 --------------GRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDG------RGDDSKA 1060
                          G R    S+       H   S +  G G++  G      RG     
Sbjct: 1662 GYGQHGSRSGQSSRGERHGSSSRSSSRYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSG 1721

Query: 1061 TGPPSQNSNIGTGRGSEGDCSPEDKNS 1087
             G  S +   G+G G      P +  S
Sbjct: 1722 LGHSSSHGQHGSGSGRSSSRGPYESRS 1748



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 128/540 (23%), Positives = 180/540 (33%), Gaps = 60/540 (11%)

Query: 596  GSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRM-----DAPASGSACSGLNKQEPGGS 650
            G SS     G   G+ +   + G      S  GR       +P  G   SG  +    G 
Sbjct: 1554 GQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGR 1613

Query: 651  HGS---ETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRK--HKADTEEKSSKAESG 705
            HGS    +  +G+      E SG  H      +    S+H     H +   +  S++   
Sbjct: 1614 HGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQS 1673

Query: 706  EKSKKRKKRKRKKNKSSAPADSERGPKPEP-PGSGSPAPPRRRRRAQDDSQRRSLPAEEG 764
             + ++     R  ++        R        GSGS   P R R         S      
Sbjct: 1674 SRGERHGSSSRSSSRYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSSSHGQHGS 1733

Query: 765  SSGKKDEGGGGSSSQDHGG--RKHKGELPPSSCQRRAGT------KRSSRSSHRSQPSSG 816
             SG+    G   S   H     +H+     SS   + G+       +    S   Q S+ 
Sbjct: 1734 GSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTF 1793

Query: 817  DEDSDD---ASSHRLHQKSPSQYSEEEEE-EDSGSEHSRSRSRSGRRHSS---HRSSRRS 869
            D++      +SSH  H    SQ S   ++   SG   SR R  SG  HSS      S   
Sbjct: 1794 DQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSG 1853

Query: 870  YSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYS 929
            +SSSS      S  S    + + S    S  ++  S   H S    + S   +S R +  
Sbjct: 1854 WSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGEQH 1913

Query: 930  SSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHS-------W 982
             S    S S  Q  S SR          G  +S S SR R    S  ++++        W
Sbjct: 1914 GSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYGSGSGW 1973

Query: 983  QRSRSYSRDRS--------RSTRS-PSQRSGSRKRSWGHESPEERH---SGRRDFI---- 1026
              SR      S        R +RS  S   G    S GH S   +H   SG+        
Sbjct: 1974 SSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQSSSCGQHG 2033

Query: 1027 ----RSKIY------RSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGS 1076
                +S  +       SQS  Y R G G G       RG  S+ + P       G+GR S
Sbjct: 2034 ASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQS-PSYGRHGSGSGRSS 2092



 Score = 81.3 bits (199), Expect = 7e-15
 Identities = 119/504 (23%), Positives = 167/504 (33%), Gaps = 45/504 (8%)

Query: 589  TEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPG 648
            T+     G SS     G   G+ ++S++ G      SS G+     SGS  S  + Q   
Sbjct: 945  TQHGSGSGHSSSYEQHGSRSGQSSRSEQHGSSSGSSSSYGQH---GSGSRQSLGHGQHGS 1001

Query: 649  GSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKS 708
            GS  S +   GR        SG+S  +   +     S  +  +++ +   S       +S
Sbjct: 1002 GSGQSPSPSRGRH----GSGSGQSSSYGPYRSGSGWSSSRGPYESGSGHSSGLGH--RES 1055

Query: 709  KKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGK 768
            +  +     ++ SS+   S  G      G  S          Q  S  +       SSG 
Sbjct: 1056 RSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGY 1115

Query: 769  KDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRL 828
              +G G   S  HG R       PS  +  +G   S RSS   Q  SG  +S     H  
Sbjct: 1116 GRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSG---SGRSSSSGQHGSGLGESSGFGHHES 1172

Query: 829  HQKSPSQYSEEEEEEDSGSEHSRSRSRSGR-----RHSSHRSSRRSYSSSSDASSDQSCY 883
                 S YS+        S + +  SRSG+     RH S   S   Y      S   S +
Sbjct: 1173 SSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQSSGH 1232

Query: 884  SRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSR 943
             RQ S S  S S    R R  S   H S    + S   RS       S   +S    Q  
Sbjct: 1233 GRQGSGSGHSPS----RGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHE 1288

Query: 944  SRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRS 1003
            S S  H+   S+  G      CS+ +          H     +S + D+  S+   S   
Sbjct: 1289 SGS-GHSSAYSQ-HGSGSGHFCSQGQ----------HGSTSGQSSTFDQEGSSTGQSSSY 1336

Query: 1004 GSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGP 1063
            G R       S   RH              QSP   R G G G        G     +G 
Sbjct: 1337 GHRGSGSSQSSGYGRHGAG---------SGQSPSRGRHGSGSG---HSSSYGQHGSGSGW 1384

Query: 1064 PSQNSNIGTGRGSEGDCSPEDKNS 1087
             S +   G+G G        + +S
Sbjct: 1385 SSSSGRHGSGSGQSSGFGHHESSS 1408



 Score = 81.3 bits (199), Expect = 7e-15
 Identities = 115/478 (24%), Positives = 157/478 (32%), Gaps = 43/478 (8%)

Query: 612  NKSKEVGGEKIVRSSGGRMDAPASGSACS----GLNKQEPGGSHGSETEDTGRSLPSKKE 667
            + S E  G +  +SS G     +SGS+ S    G   ++  G HG     +G+S    + 
Sbjct: 2364 SSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLG-HGQHGSGSGQSPSPSRG 2422

Query: 668  RSGKSHRHKKKKKHKKSSKHKRKHKADTEEKS--SKAESGEKSKKRKKRKRKKNKSSAPA 725
            R G             S       +   E  S  S      +S+  +     ++ SS+  
Sbjct: 2423 RHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGH 2482

Query: 726  DSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRK 785
             S  G      G  S          Q  S  +       SSG   +G G   S  HG R 
Sbjct: 2483 SSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRG 2542

Query: 786  HKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDS 845
                  PS  +  +G   S RSS   Q  SG  +S     H       S YS+       
Sbjct: 2543 SGSRQSPSYGRHGSG---SGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGH 2599

Query: 846  GSEHSRSRSRSGR-----RHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDR 900
             S + +  SRSG+     RH S   S   Y      S   S + RQ S S  S S    R
Sbjct: 2600 SSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQSPS----R 2655

Query: 901  SRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRS 960
             R  S   H S    + S   RS       S   +S    Q  S S  H+   S+  G  
Sbjct: 2656 GRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRLGHSSVFGQHESGS-GHSSAYSQ-HGSG 2713

Query: 961  RSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHS 1020
                CS+ +          H     +S + D+  S+   S   G R       S   RH 
Sbjct: 2714 SGHFCSQGQ----------HGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSSQSSGYGRHG 2763

Query: 1021 GRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEG 1078
                         QS  + R G G G   +    G     +G  S  S  G+G G +G
Sbjct: 2764 AG---------SGQSLSHGRHGSGSG---QSSSYGQHGSGSGQSSGYSQHGSGSGQDG 2809



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 114/457 (24%), Positives = 155/457 (33%), Gaps = 56/457 (12%)

Query: 636  GSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADT 695
            G   SG  +    G HGS +  +  S  +    SG+S    + K     S    +H + +
Sbjct: 193  GQCGSGSGQSPNYGQHGSGSGQSS-SNDTHGSGSGQSSGFSQHKSSSGQSSGYSQHGSGS 251

Query: 696  EEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQ 755
               S   + G +S +  + +R ++ S + +   +         G        R++    +
Sbjct: 252  GHSSGYGQHGSRSGQSSRGERHRSSSGSSSSYGQHGSGSRQSLGHGRQGSGSRQSPSHVR 311

Query: 756  RRSLPAEEGSSGKKDEGGGGSSSQDH-----GGRKHKGELPPSSCQRRAGTKRSSRSSHR 810
              S      S G+   G   S S+ H     G     G+    S Q    +K  S S H 
Sbjct: 312  HGSGSGHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQSSGYSKHGSGSGHS 371

Query: 811  SQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSR--SGRRHSSHRSSRR 868
            S        S  ASS   H  S S+ S    + +S S HS  R +  SG   S     R 
Sbjct: 372  SSQGQHGSTSGQASSSGQHGSS-SRQSSSYGQHESASRHSSGRGQHSSGSGQSPGHGQRG 430

Query: 869  SYSSSSDASSDQSCYSRQRSYSDDSY---SDYSDRSRRH-SKRSHDSDDSDYASSKHRSK 924
            S S  S  SS Q      RS S   Y   S YS     H S   H S  + + S    S 
Sbjct: 431  SGSGQS-PSSGQHGTGFGRSSSSGPYVSGSGYSSGFGHHESSSEHSSGYTQHGSGSGHSS 489

Query: 925  RHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQR 984
             H                +  SRS    R   +G S  SS S  +    SR +  H    
Sbjct: 490  GH---------------GQHGSRSGQSSRGERQGSSAGSSSSYGQHGSGSRQSLGH---- 530

Query: 985  SRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRG 1044
                SR  S S +SPS   G       HES   + S            S  PH + SGR 
Sbjct: 531  ----SRHGSGSGQSPSPSRGR------HESGSRQSS------------SYGPHGYGSGRS 568

Query: 1045 EGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCS 1081
               G  + G G  S   G     S   +G G  G  S
Sbjct: 569  SSRGPYESGSG-HSSGLGHQESRSGQSSGYGQHGSSS 604



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 119/475 (25%), Positives = 167/475 (35%), Gaps = 43/475 (9%)

Query: 626  SGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSS 685
            S G   +P  G   SG  +    G HG+     GRS  S    SG  +       H+ SS
Sbjct: 417  SSGSGQSPGHGQRGSGSGQSPSSGQHGT---GFGRSSSSGPYVSGSGYS-SGFGHHESSS 472

Query: 686  KHKR---KHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPA 742
            +H     +H + +   S   + G +S +  + +R+   SSA + S  G      GSGS  
Sbjct: 473  EHSSGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQG--SSAGSSSSYGQH----GSGSRQ 526

Query: 743  PPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTK 802
                 R      Q  S       SG +     G      G    +G     S        
Sbjct: 527  SLGHSRHGSGSGQSPSPSRGRHESGSRQSSSYGPHGYGSGRSSSRGPYESGSGHSSGLGH 586

Query: 803  RSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSE-EEEEEDSGSEHSRSRSRSGRRHS 861
            + SRS   S        S  +S+H  H  +  Q S   +    SG   S  +  SG   S
Sbjct: 587  QESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQS 646

Query: 862  SHRSSRRSYSSSSDASSDQ-SCYSRQRSYSDD-SYSDYSDRSRRHSKRSHDSDDSDYASS 919
            S    + S S  S +     S +    SY    S S +S  +  H   S  S    + S 
Sbjct: 647  SRYGQQGSGSGQSPSRGRHGSDFGHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKSG 706

Query: 920  KHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTA 979
              +S  +    S   +S    +  SRS     + SRS     SS  S S  +  S S   
Sbjct: 707  SGQSSGYSQHGSGSSHSSGYRKHGSRSG----QSSRSEQHGSSSGLSSSYGQHGSGS--- 759

Query: 980  HSWQRSRSYSRDRSRSTRSPSQ-RSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHY 1038
                +S  + R  S S  SPS+ R GS   S GH S   +H        S    S S  +
Sbjct: 760  ---HQSSGHGRQGSGSGHSPSRVRHGS---SSGHSSSHGQHG-------SGTSCSSSCGH 806

Query: 1039 FRSGRGE--GPGKKDDGRG----DDSKATGPPSQNSNIGTGRGSEGDCSPEDKNS 1087
            + SG G+  G G+ + G G        A+G  S     G+  G        D +S
Sbjct: 807  YESGSGQASGFGQHESGSGQGYSQHGSASGHFSSQGRHGSTSGQSSSSGQHDSSS 861



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 118/482 (24%), Positives = 167/482 (34%), Gaps = 45/482 (9%)

Query: 619  GEKIVRSSGGRMDAPASGSACS----GLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHR 674
            G +  +SS G     +SGS+      G   ++  G HG +   +G S    +  SG  H 
Sbjct: 2137 GSRSGQSSRGERHGSSSGSSSRYGQHGSGSRQSSG-HGRQGSGSGHSPSRGRHGSGSGHS 2195

Query: 675  HKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPE 734
                +    S +   +   ++    S      +S         ++ S +     +G    
Sbjct: 2196 SSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGS 2255

Query: 735  PPGSGSPAPPRRRRRAQDDS--QRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPP 792
              G  S          Q  S  Q  S  ++  S G++  G G S S+   GR   G    
Sbjct: 2256 TSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSR---GRHGSGSGHS 2312

Query: 793  SSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRS 852
            SS  +       S SS R    SG       SS   H +S S  S    +  SGS HS S
Sbjct: 2313 SSYGQHGSGSGWSSSSGRHGSGSGQ------SSGFGHHESSSWQSSGYTQHGSGSGHSSS 2366

Query: 853  RSRSGRRHS-SHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDS 911
              + G R   S R  R   SS S +S  Q     ++S     +   S +S   S+  H S
Sbjct: 2367 YEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGS 2426

Query: 912  DDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSK 971
                 +S         +SSS   Y      S       +R    S      SS   S + 
Sbjct: 2427 GSGQSSSYSPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTH 2486

Query: 972  RRSRSTTAHSWQ-----RSRSYSRDRSRSTRSPSQRSG-SRKRSWGHESP--EERHSGRR 1023
             +  ST+  S        S   S    +     SQ SG  R+ S   +SP   +R SG R
Sbjct: 2487 GQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSR 2546

Query: 1024 DFIRSKIYRSQSPHYFRSGRGEG----PGKKDDGRGDDS------KATGPPSQNSNIGTG 1073
                      QSP Y R G G G     G+   G G+ S       ++G  S  S  G+G
Sbjct: 2547 ----------QSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSG 2596

Query: 1074 RG 1075
             G
Sbjct: 2597 SG 2598



 Score = 77.8 bits (190), Expect = 7e-14
 Identities = 134/541 (24%), Positives = 186/541 (34%), Gaps = 102/541 (18%)

Query: 624  RSSGGRMDAPASGSACSGLNKQEPGGSHGS---ETEDTGRSLPSKKE------------- 667
            R SG R  +P+ G   SG  +    G HGS   E+   G    S  +             
Sbjct: 1601 RGSGSRQ-SPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGH 1659

Query: 668  ---------RSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRK- 717
                     RSG+S R ++     +SS    +H + + + S     G  S +   R R  
Sbjct: 1660 SSGYGQHGSRSGQSSRGERHGSSSRSSSRYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHG 1719

Query: 718  ----------KNKSSAPADSERGPKPEPPG----------------------SGSPAPPR 745
                      ++ S +   S RGP     G                      SGS     
Sbjct: 1720 SGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCS 1779

Query: 746  RRRRAQDDSQRRSLPAEEGSSGKKDE----GGGGSSSQDHGGRKHKGELPPSSCQRRAGT 801
            + +      Q  +   E  S+G+       G G S S  +G +       PS  +  +G+
Sbjct: 1780 QGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGS 1839

Query: 802  KRSSR-SSHRS----QPSSGDEDSDDASSHRL-HQKSPSQYSEEEEEEDSGSEHSRSRSR 855
              SS    H S      SSG   S    S    H +S S  S    +  SGS HS S  +
Sbjct: 1840 GHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQ 1899

Query: 856  SGRRHS-SHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDS 914
             G R   S R  +   SS S +S  Q     ++S     +   S +S   S+  H S   
Sbjct: 1900 HGSRSGQSSRGEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSG 1959

Query: 915  DYAS-------SKHRSKRHKY-SSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCS 966
              +S       S   S R  Y S S     L   +SRS   S   +   S G S S+   
Sbjct: 1960 QSSSYGPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHS-STHGQ 2018

Query: 967  RSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESP--EERHSGRRD 1024
               +  +S S   H     +S S  +  S  S S   G R+ S   +SP   +R SG R 
Sbjct: 2019 HGSASGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYG-RQGSGSGQSPGHGQRGSGSR- 2076

Query: 1025 FIRSKIYRSQSPHYFRSGRG---------EGPG-KKDDGRGDDSKATGPPSQNSNIGTGR 1074
                     QSP Y R G G          GPG  +  G G    ++G  S  S  G+G 
Sbjct: 2077 ---------QSPSYGRHGSGSGRSSSSGQHGPGLGESSGFGHHESSSGQSSSYSQHGSGS 2127

Query: 1075 G 1075
            G
Sbjct: 2128 G 2128



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 118/504 (23%), Positives = 168/504 (33%), Gaps = 33/504 (6%)

Query: 596  GSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRM-----DAPASGSACSGLNKQEPGGS 650
            G SS     G   G+ +   + G      S  GR       +P  G   SG  +    G 
Sbjct: 1084 GQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGR 1143

Query: 651  HGSETEDTGRSLPSKKERSG--KSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKS 708
            HGS    +GRS  S +  SG  +S      +     S    +H + +   S   + G +S
Sbjct: 1144 HGS---GSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRS 1200

Query: 709  KKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGK 768
             +  + +R  + SS+ + S  G      GSGS       R++    ++ S      S G+
Sbjct: 1201 GQSSRGER--HGSSSGSSSHYGQH----GSGS-------RQSSGHGRQGSGSGHSPSRGR 1247

Query: 769  KDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRL 828
               G G SSS  HG     G     S  R     RS  SS   Q  SG   S   S H  
Sbjct: 1248 HGSGLGHSSS--HG---QHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGS 1302

Query: 829  HQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHS-SHRSSRRSYSSSSDASSDQSCYSRQR 887
                     +        S   +  S +G+  S  HR S  S SS        S  S  R
Sbjct: 1303 GSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSSQSSGYGRHGAGSGQSPSR 1362

Query: 888  SYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRS--- 944
                      S   +  S     S    + S   +S    +  S    S  C+Q  S   
Sbjct: 1363 GRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGCTQHGSGSG 1422

Query: 945  RSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSG 1004
             S S+ +  SRS   SR      S     S        ++S  + +  S S +SPS   G
Sbjct: 1423 HSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRG 1482

Query: 1005 SRKRSWGHESPEERHSGRRDFIRSK-IYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGP 1063
                  G  S    +     +  S+  Y S S H    G  E    +  G G    ++G 
Sbjct: 1483 RHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGH 1542

Query: 1064 PSQNSNIGTGRGSEGDCSPEDKNS 1087
             S +   G+  G    C     +S
Sbjct: 1543 SSTHGQHGSTSGQSSSCGQHGASS 1566



 Score = 74.7 bits (182), Expect = 6e-13
 Identities = 133/566 (23%), Positives = 178/566 (31%), Gaps = 101/566 (17%)

Query: 596  GSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSET 655
            G SS     G   G  + S   G      S  G  ++ +  S  SG  +   G  H S  
Sbjct: 1840 GHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQS--SGYTQHGSGSGHSSSY 1897

Query: 656  EDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRK 715
            E  G        RSG+S R ++      SS    +H + + +     + G  S +     
Sbjct: 1898 EQHG-------SRSGQSSRGEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPS 1950

Query: 716  RKKNKSSAPADSERGPKPEPPGSGSPAPP-------------RRRRRAQDDS-------- 754
            R ++ S +   S  GP     G  S   P             R  R  Q           
Sbjct: 1951 RGRHGSGSGQSSSYGPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSS 2010

Query: 755  -------QRRSLP----------AEEGSSGKKDEGGGGSSSQDHGGRKHKGE-LPPSSCQ 796
                   Q  S            A  G S    + G GSS     GR+  G    P   Q
Sbjct: 2011 GHSSTHGQHGSASGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQ 2070

Query: 797  RRAGTKR----------SSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSG 846
            R +G+++          S RSS   Q   G  +S     H       S YS+        
Sbjct: 2071 RGSGSRQSPSYGRHGSGSGRSSSSGQHGPGLGESSGFGHHESSSGQSSSYSQHGSGSGHS 2130

Query: 847  SEHSRSRSRSGR-----RHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRS 901
            S + +  SRSG+     RH S   S   Y      S   S + RQ S S  S S    R 
Sbjct: 2131 SGYGQHGSRSGQSSRGERHGSSSGSSSRYGQHGSGSRQSSGHGRQGSGSGHSPS----RG 2186

Query: 902  RRHSKRSHDSDDSDYASSKHRSK----------------RHK--------YSSSDDDYSL 937
            R  S   H S    + S   RS                 +H+        YS        
Sbjct: 2187 RHGSGSGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGH 2246

Query: 938  SCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRS---RSYSRDRSR 994
             CSQ +  S S         G S   S S  +    S  ++++  Q S   +S SR R  
Sbjct: 2247 FCSQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHG 2306

Query: 995  STRSPSQRSGSRKRSWGHESPEERH---SGRRD-FIRSKIYRSQSPHYFRSGRGEGPGKK 1050
            S    S   G      G  S   RH   SG+   F   +    QS  Y + G G G    
Sbjct: 2307 SGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSS 2366

Query: 1051 DDGRGDDSKATGPPSQNSNIGTGRGS 1076
             +  G  S   G  S+    G+  GS
Sbjct: 2367 YEQHGSRS---GQSSRGERHGSSSGS 2389



 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 120/517 (23%), Positives = 162/517 (31%), Gaps = 68/517 (13%)

Query: 596  GSSSKDHLQGLDPGEPNK-------SKEVGGEKIVRSSGGRMDAPASGSACSGLNKQE-- 646
            G SS+    G   G  +        S++  G     S  G+  +P+ G   SG  +    
Sbjct: 1435 GQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSY 1494

Query: 647  -PGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKK------HKKSSKHKRKHKADTEEKS 699
             P GS    +   G         SG  HR  +  +      H  SS H   H        
Sbjct: 1495 SPYGSGSGWSSSRGPYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSG 1554

Query: 700  SKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSL 759
              +  G+              +S+   S  G      GSGS       R+     Q    
Sbjct: 1555 QSSSCGQHG------------ASSGQSSSHGQH----GSGSSQSSGYGRQGSGSGQ---- 1594

Query: 760  PAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDED 819
                 S G    G G   S  +G          SS Q  +G   SS   H    S     
Sbjct: 1595 -----SPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSS 1649

Query: 820  SDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRS-SRRSYSSSSDASS 878
                 S   H     Q+     +   G  H  S SRS  R+  H S SR+S       S 
Sbjct: 1650 YSQHGSGSGHSSGYGQHGSRSGQSSRGERHG-SSSRSSSRYGQHGSGSRQSSGHGRQGSG 1708

Query: 879  DQSCYSRQRSYS----DDSYSDYSDRSRRHSKRSHDSDDSDYAS--------SKHRSKRH 926
                 SR R  S      S+  +   S R S R      S ++S        S H S   
Sbjct: 1709 SGQSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYS 1768

Query: 927  KYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRS- 985
            ++ S    +   CSQ +  S S         G S   S S  +    S  ++++  Q S 
Sbjct: 1769 QHGSGSGHF---CSQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSG 1825

Query: 986  --RSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERH---SGRRD-FIRSKIYRSQSPHYF 1039
              +S SR R  S    S   G      G  S   RH   SG+   F   +    QS  Y 
Sbjct: 1826 SGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYT 1885

Query: 1040 RSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGS 1076
            + G G G     +  G  S   G  S+    G+  GS
Sbjct: 1886 QHGSGSGHSSSYEQHGSRS---GQSSRGEQHGSSSGS 1919



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 123/532 (23%), Positives = 177/532 (33%), Gaps = 41/532 (7%)

Query: 690  KHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRR 749
            K + DT +   + E  EK ++ K+++   + SS  A           GS  P      RR
Sbjct: 100  KLRDDTHQHQEEQEETEK-EENKRQESSFSHSSWSAGENDSYSRNVRGSLKPGTESISRR 158

Query: 750  AQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDH--GGRKHKGELPPSSCQRRAGTKRSSRS 807
                S +R    +  S   +    G  +S  H   GR   G     S         S +S
Sbjct: 159  L---SFQRDFSGQHNSYSGQSSSYGEQNSDSHQSSGRGQCGSGSGQSPNYGQHGSGSGQS 215

Query: 808  SHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSR 867
            S      SG   S   S H+      S YS+      SGS HS    + G R        
Sbjct: 216  SSNDTHGSGSGQSSGFSQHKSSSGQSSGYSQH----GSGSGHSSGYGQHGSRSGQSSRGE 271

Query: 868  RSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHK 927
            R  SSS  +SS    Y +  S S  S       S      SH      + S    S  H 
Sbjct: 272  RHRSSSGSSSS----YGQHGSGSRQSLGHGRQGSGSRQSPSHVR----HGSGSGHSSSHG 323

Query: 928  YSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRS 987
               S   YS S     S S   +       G  +SS  S+  S       + HS  + + 
Sbjct: 324  QHGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQSSGYSKHGSG------SGHSSSQGQH 377

Query: 988  YSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGP 1047
             S     S+      S  +  S+G      RHS  R    S   +S       SG G+ P
Sbjct: 378  GSTSGQASSSGQHGSSSRQSSSYGQHESASRHSSGRGQHSSGSGQSPGHGQRGSGSGQSP 437

Query: 1048 GKKDDGRG-DDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVER-- 1104
                 G G   S ++GP    S   +G G   + S E  +  T         S   +   
Sbjct: 438  SSGQHGTGFGRSSSSGPYVSGSGYSSGFGHH-ESSSEHSSGYTQHGSGSGHSSGHGQHGS 496

Query: 1105 KPSVSEEVQATPNKAGPKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNKKCEES 1164
            +   S   +   + AG        G  G     SLG+       G+ P+   P++   ES
Sbjct: 497  RSGQSSRGERQGSSAG---SSSSYGQHGSGSRQSLGHSRHGSGSGQSPS---PSRGRHES 550

Query: 1165 GLERGEEQEQSETEEGPPGSSDALFGHQFPSEETTGPLLDPPPEESKSGEAT 1216
            G        +  +  GP G        + P E  +G       +ES+SG+++
Sbjct: 551  G-------SRQSSSYGPHGYGSGRSSSRGPYESGSGHSSGLGHQESRSGQSS 595



 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 93/405 (22%), Positives = 138/405 (34%), Gaps = 44/405 (10%)

Query: 672  SHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGP 731
            +H+H+++++  +  ++KR+  + +    S  E+   S+  +   +   +S +   S +  
Sbjct: 105  THQHQEEQEETEKEENKRQESSFSHSSWSAGENDSYSRNVRGSLKPGTESISRRLSFQRD 164

Query: 732  KPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELP 791
                  S S        +  D  Q         SSG+   G G   S ++G         
Sbjct: 165  FSGQHNSYSGQSSSYGEQNSDSHQ---------SSGRGQCGSGSGQSPNYG--------- 206

Query: 792  PSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSR 851
                Q  +G   S +SS      SG   S   S H    KS S  S    +  SGS HS 
Sbjct: 207  ----QHGSG---SGQSSSNDTHGSGSGQSSGFSQH----KSSSGQSSGYSQHGSGSGHSS 255

Query: 852  SRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDS 911
               + G R        R  SSS  +SS    Y +  S S  S       S      SH  
Sbjct: 256  GYGQHGSRSGQSSRGERHRSSSGSSSS----YGQHGSGSRQSLGHGRQGSGSRQSPSH-- 309

Query: 912  DDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSK 971
                + S    S  H    S   YS S     S S   +       G  +SS  S     
Sbjct: 310  --VRHGSGSGHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQSSGYS----- 362

Query: 972  RRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIY 1031
             +  S + HS  + +  S     S+      S  +  S+G      RHS  R    S   
Sbjct: 363  -KHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSSGRGQHSSGSG 421

Query: 1032 RSQSPHYFRSGRGEGPGKKDDGRG-DDSKATGPPSQNSNIGTGRG 1075
            +S       SG G+ P     G G   S ++GP    S   +G G
Sbjct: 422  QSPGHGQRGSGSGQSPSSGQHGTGFGRSSSSGPYVSGSGYSSGFG 466



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 73/279 (26%), Positives = 107/279 (38%), Gaps = 24/279 (8%)

Query: 815  SGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSS 874
            SG +  DD   H+  Q+     +E+EE +   S  S S   +G   S  R+ R S    +
Sbjct: 97   SGSKLRDDTHQHQEEQEE----TEKEENKRQESSFSHSSWSAGENDSYSRNVRGSLKPGT 152

Query: 875  DASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASS---------KHRSKR 925
            ++ S +  + R  S   +SYS  S      +  SH S       S         +H S  
Sbjct: 153  ESISRRLSFQRDFSGQHNSYSGQSSSYGEQNSDSHQSSGRGQCGSGSGQSPNYGQHGSGS 212

Query: 926  HKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRS---KRRSRSTTAHSW 982
             + SSS+D +     QS   S+ H     +S G S+  S S   S   +  SRS  +   
Sbjct: 213  GQ-SSSNDTHGSGSGQSSGFSQ-HKSSSGQSSGYSQHGSGSGHSSGYGQHGSRSGQSSRG 270

Query: 983  QRSRSYSRDRS----RSTRSPSQRSGSRKRSWGHESPEE-RH-SGRRDFIRSKIYRSQSP 1036
            +R RS S   S      + S       R+ S   +SP   RH SG         + S S 
Sbjct: 271  ERHRSSSGSSSSYGQHGSGSRQSLGHGRQGSGSRQSPSHVRHGSGSGHSSSHGQHGSGSS 330

Query: 1037 HYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRG 1075
            + +  G  E    +  G G     +G  S  S  G+G G
Sbjct: 331  YSYSRGHYESGSGQTSGFGQHESGSGQSSGYSKHGSGSG 369



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 81/348 (23%), Positives = 115/348 (33%), Gaps = 31/348 (8%)

Query: 596  GSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRM-----DAPASGSACSGLNKQEPGGS 650
            G SS     G   G+ +   + G      S  GR       +P  G   SG  +    G 
Sbjct: 2494 GQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGR 2553

Query: 651  HGSETEDTGRSLPSKKERSG--KSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKS 708
            HGS    +GRS  S +  SG  +S      +     S    +H + +   S   + G +S
Sbjct: 2554 HGS---GSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRS 2610

Query: 709  KKRKKRKRKKNKSSAPAD-------SERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPA 761
             +  + +R  + S + +        S +       GSGS   P R R         S   
Sbjct: 2611 GQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSSSHGQ 2670

Query: 762  EEGSSGKKDEGGGGSSSQDHGG--RKHKGELPPSSCQRRAGT------KRSSRSSHRSQP 813
                SG+    G   S   H     +H+     SS   + G+       +    S   Q 
Sbjct: 2671 HGSGSGRSSSRGPYESRLGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQS 2730

Query: 814  SSGDED--SDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYS 871
            S+ D++  S   SS   H+ S S  S       +GS  S S      RH S      SY 
Sbjct: 2731 STFDQEGSSTGQSSSYGHRGSGSSQSSGYGRHGAGSGQSLSHG----RHGSGSGQSSSYG 2786

Query: 872  SSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASS 919
                 S   S YS+  S S      Y      H   S  S    + SS
Sbjct: 2787 QHGSGSGQSSGYSQHGSGSGQDGYSYCKGGSNHDGGSSGSYFLSFPSS 2834


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 163/736 (22%), Positives = 251/736 (34%), Gaps = 114/736 (15%)

Query: 645  QEPGGSHGSETEDTGR-----SLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKS 699
            +EP     + T D  +      +P  KE S + +  K+K+K K   + + + K+ +  +S
Sbjct: 231  KEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRS 290

Query: 700  SKAESGEKSKKRKKRKRKKNKSSAPADSER-GPKPEPPGSGSPAPPRRRR-RAQDDSQRR 757
                     ++ + R R  +    P+   R  P+   P    P PPR RR R+    +RR
Sbjct: 291  RSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRR 350

Query: 758  SLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGD 817
            S  +  GSS         SSS     R      PP    +R  T    R + R  PS+  
Sbjct: 351  SSASLSGSS---------SSSSSSRSRS-----PPKKPPKR--TSSPPRKTRRLSPSA-- 392

Query: 818  EDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDAS 877
                 +   R H+ SP      +      + HS +  +S R   S  S   S   +S   
Sbjct: 393  -----SPPRRRHRPSPPATPPPK------TRHSPTPQQSNRTRKSRVSV--SPGRTSGKV 439

Query: 878  SDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSL 937
            +      ++ S S        + S     +      +D    + + +R    SS D  S 
Sbjct: 440  TKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSS 499

Query: 938  SCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTR 997
            S S+     RSH +     R R  S S S S S R+ +  T+   +R RS S   +R  R
Sbjct: 500  SSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRR 559

Query: 998  SPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDD 1057
            SPS     R+R      P  R        RS   R  SP   R      P K+       
Sbjct: 560  SPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKR------- 612

Query: 1058 SKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPN 1117
              A+ PP                SP  K              R+V   P   +       
Sbjct: 613  RTASPPPPPKRRASP--------SPPPK--------------RRVSHSPPPKQRSSPVTK 650

Query: 1118 KAGPKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNKKCEESGLERGEEQEQSET 1177
            +  P L    +    P         P            +PNK+   S   R       +T
Sbjct: 651  RRSPSLSSKHRKGSSPSRSTREARSP------------QPNKRHSPSPRPRA-----PQT 693

Query: 1178 EEGPP----GSSDALFGHQFPSEETTGPL--LDPPPEESKSGEATADHPVAPLGTPAHSD 1231
               PP    G+S +    Q PS  +T P+  +   PE  K  +A +  P + +   + S 
Sbjct: 694  SSSPPPVRRGASSSPQRRQSPS-PSTRPIRRVSRTPEPKKIKKAASPSPQS-VRRVSSSR 751

Query: 1232 CYPGDPTISHNYLPDPSDGDTLESLDSSSQPGPVESSLLPIAPDLEHFPSYAPPSGDPSI 1291
               G P  +    P P       S   S  P    S  +P+       PS +PP    S 
Sbjct: 752  SVSGSPEPAAKKPPAP------PSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRN--SD 803

Query: 1292 ESTDGAEDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASAALAP 1351
            +   G +                ++  K  K  +  ++H +++ +A    A    AA+A 
Sbjct: 804  QEGGGKKKKK-----------KKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAA 852

Query: 1352 ATPAL---QPIHIQQP 1364
            AT  L   +P+   +P
Sbjct: 853  ATTTLAQEEPVAAPEP 868



 Score = 77.8 bits (190), Expect = 7e-14
 Identities = 158/729 (21%), Positives = 253/729 (34%), Gaps = 105/729 (14%)

Query: 666  KERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPA 725
            K+   K  + +++K      + + K K D EEK S  E  E+S+  ++RK +        
Sbjct: 127  KKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSR-------- 178

Query: 726  DSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRK 785
                   P P    SP   R R+R+   S R    +   S   +              ++
Sbjct: 179  ------SPSPRRRSSPV-RRERKRSHSRSPRHRTKSRSPSPAPEK-------------KE 218

Query: 786  HKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDS 845
               ELP  S + +  + + + S+         E   +       + SP + S++E+E++ 
Sbjct: 219  KTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPK-----EPSPEKNSKKEKEKEK 273

Query: 846  ----GSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRS 901
                    S+SRSR+  R  SH   RR + S S + S +   S +R          S R 
Sbjct: 274  TRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRR--------PSPRR 325

Query: 902  RRHSKRSHDSDDSDYASSKHRSKRHKYSS-SDDDYSLSCSQSRSRSRSHTRERSRSRGRS 960
            R   +R         + S  R +R   +S S    S S S+SRS  +   +  S    ++
Sbjct: 326  RTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKT 385

Query: 961  RSSSCSRSRSKRRSRST--------TAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWG- 1011
            R  S S S  +RR R +        T HS    +S    +SR + SP + SG   +  G 
Sbjct: 386  RRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGT 445

Query: 1012 --HESPEERHSGRRDFIR-------SKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATG 1062
               ESP      R+  +         K+  + S    R  R +      D  G  S +  
Sbjct: 446  EKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDS-GSSSSSED 504

Query: 1063 PPSQNSNIGTGR-GSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPNKAGP 1121
               + S++  G  G     SP    S + +   ++   R   R+   S     T  +  P
Sbjct: 505  ERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRR---SPSPPPTRRRRSP 561

Query: 1122 KLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNKKCEESGLERGEEQEQSETEEGP 1181
                PP+    P  PP     P  P     P  R P+ +       R     Q      P
Sbjct: 562  SPAPPPRRRRTP-TPPPRRRTPSPP-----PRRRSPSPR-------RYSPPIQRRYSPSP 608

Query: 1182 PGSSDALFGHQFPSEETTGPLLDPPPEESKSGEATADHPVAPLGTPAHSDCYP----GDP 1237
            P           P   T  P   PPP + ++  +           P      P      P
Sbjct: 609  P-----------PKRRTASP---PPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSP 654

Query: 1238 TISHNYLPDPSDGDTLESLDSSSQPGPVESSLLPIAPDLEHFPSYAPPSGDPSIESTDGA 1297
            ++S  +    S   +     S         S  P AP     P   PP    +  S    
Sbjct: 655  SLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSP---PPVRRGASSSPQRR 711

Query: 1298 EDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASAALAPATPALQ 1357
            +  S +    + ++ TPE  +K  K    + Q +++   ++ V   P  AA  P  P   
Sbjct: 712  QSPSPSTRPIRRVSRTPEP-KKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPP-S 769

Query: 1358 PIHIQQPAT 1366
            P+  Q P+T
Sbjct: 770  PVQSQSPST 778



 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 147/745 (19%), Positives = 257/745 (34%), Gaps = 77/745 (10%)

Query: 336  EKSSDQGLQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYH 395
            E   ++  Q+  + +  +++  + ED+D +D     S+  K +R +      +  P    
Sbjct: 125  ELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRR 184

Query: 396  YIPPAHCKVKPNFPFLLFMRASEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAE 455
               P   + K +        +        +  P  APE K+ +   P+  +K       E
Sbjct: 185  RSSPVRRERKRS-------HSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQE 237

Query: 456  KT-VSEVSEQPKETSMTEPSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSK 514
             T  S++ + PK   + EP EP  +  +KK           E   +K        S S  
Sbjct: 238  ATSTSDILKVPKPEPIPEPKEPSPEKNSKK-----------EKEKEKTRPRSRSRSKSRS 286

Query: 515  ETSLATPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYF 574
             T   +P+    +   +  +  + P   +   +  + PS      +  P       P + 
Sbjct: 287  RTRSRSPSHTRPRRRHRSRSRSYSP---RRRPSPRRRPSP----RRRTPPRRMPPPPRH- 338

Query: 575  DFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPA 634
              + SR+   R + +       SSS    +   P +    +     +  R        P 
Sbjct: 339  --RRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPR 396

Query: 635  SGSACSGLNKQEPGGSHGSETEDTGRSLPSK-----KERSGKSHRHKKKKKHKKSSKHKR 689
                 S      P   H    + + R+  S+        SGK  +HK  +K +  S   +
Sbjct: 397  RRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPK 456

Query: 690  KHKAD----TEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPR 745
              K +     E+K  K  + +  ++R++ +R+  +SS+ + S    + E P         
Sbjct: 457  PRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRS------ 510

Query: 746  RRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSS 805
              +  +   +RR  P+   S   +             GR+ +   PP + +RR     + 
Sbjct: 511  HVKNGEVGRRRRHSPSRSASPSPRKR----QKETSPRGRRRRSPSPPPT-RRRRSPSPAP 565

Query: 806  RSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRS-----GRRH 860
                R  P+        +   R    SP +YS   +   S S   + R+ S      RR 
Sbjct: 566  PPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRA 625

Query: 861  SSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSK 920
            S     +R  S S       S  +++RS S          S +H K S  S  +  A S 
Sbjct: 626  SPSPPPKRRVSHSPPPKQRSSPVTKRRSPS---------LSSKHRKGSSPSRSTREARSP 676

Query: 921  HRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAH 980
              +KRH  S           Q+ S      R  S S  R +S S S    +R SR+    
Sbjct: 677  QPNKRHSPSPRP-----RAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPK 731

Query: 981  SWQRSRSYSRDRSRSTRSPSQRSGS----RKRSWGHESPEERHSGRRDF-----IRSKIY 1031
              +++ S S    R   S    SGS     K+     SP +  S   ++     ++    
Sbjct: 732  KIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKS 791

Query: 1032 RSQSPHYFRSGRGEGPGKKDDGRGD 1056
             + SP   R+   EG GKK   + D
Sbjct: 792  PTPSPSPPRNSDQEGGGKKKKKKKD 816



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 136/616 (22%), Positives = 212/616 (34%), Gaps = 108/616 (17%)

Query: 610  EPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETED-TGRSLPSKKER 668
            E N  KE   EK    S  R  +  S +     +   P   H S +   + R  PS + R
Sbjct: 262  EKNSKKEKEKEKTRPRSRSRSKS-RSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRR 320

Query: 669  SGKSHRHKKKK-----KHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSA 723
                 R   ++     +H++S    R+ +  +   S  + S   S+ R   K+   ++S+
Sbjct: 321  PSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSS 380

Query: 724  PADSERGPKPEPPGSGSPAPPRRRRR----AQDDSQRRSLPAEEGSSGKKDEGGGGSSSQ 779
            P    R   P      S +PPRRR R    A    + R  P  + S+  +      S  +
Sbjct: 381  PPRKTRRLSP------SASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGR 434

Query: 780  DHGG-RKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSE 838
              G   KHKG                  +  R  PS   +              P +   
Sbjct: 435  TSGKVTKHKG------------------TEKRESPSPAPK--------------PRKVEL 462

Query: 839  EEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYS 898
             E EED G + + + S   RR    ++ + S  S S +SS+     R    + +      
Sbjct: 463  SESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGE-----V 517

Query: 899  DRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRG 958
             R RRHS           ++S    KR K +S       S S   +R R         R 
Sbjct: 518  GRRRRHS--------PSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRR 569

Query: 959  RSRSSSCSRSRS-----KRRSRSTTAHSWQRSRSYS-----RDRSRSTRSPSQRSGS--- 1005
            R   +   R R+     +RRS S   +S    R YS     + R+ S   P +R  S   
Sbjct: 570  RRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSP 629

Query: 1006 -RKRSWGHESPEERHSG-----RRDFIRSKIYRSQSP-HYFRSGRGEGPGKKDDGRGDDS 1058
              KR   H  P ++ S      R   + SK  +  SP    R  R   P K+        
Sbjct: 630  PPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKR---HSPSP 686

Query: 1059 KATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVE--------------- 1103
            +   P + +S     RG+    SP+ + S +      +  SR  E               
Sbjct: 687  RPRAPQTSSSPPPVRRGASS--SPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSV 744

Query: 1104 RKPSVSEEVQATPNKAGPKLKDPPQGYFGPKLPPSLGNKPVLPL---IGKLPATRKPNKK 1160
            R+ S S  V  +P  A  K   PP         PS    P +P+       P+   P   
Sbjct: 745  RRVSSSRSVSGSPEPAAKKPPAPPSPV--QSQSPSTNWSPAVPVKKAKSPTPSPSPPRNS 802

Query: 1161 CEESGLERGEEQEQSE 1176
             +E G ++ ++++  +
Sbjct: 803  DQEGGGKKKKKKKDKK 818



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 81/397 (20%), Positives = 128/397 (32%), Gaps = 17/397 (4%)

Query: 309 PVKLESIASVFKDHAEEGTSEDGTKPDEKSSDQGLQKVGDSDGSSNLDGKKEDEDPQDGG 368
           P K+E ++   +D   +  + D  +   +   Q  Q   DS  SS+     EDE P+   
Sbjct: 457 PRKVE-LSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSS----SEDERPKRSH 511

Query: 369 SLASTLSKLKRMKREEGAGATEPEYYHYIPP-AHCKVKPNFPFLLFMRASEQMDGDNTTH 427
                + + +R      A  +  +      P    +  P+ P     R+           
Sbjct: 512 VKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRR 571

Query: 428 PKNAPESKKGSSPKPK--SCIKAAASQGAEKTVSEVSEQPKETSMTEPSEPGSKAEAKKA 485
               P  ++  SP P+  S      S   ++  S  S  PK  + + P  P  +A     
Sbjct: 572 TPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSP-SPPPKRRTASPPPPPKRRASPSPP 630

Query: 486 LGGDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQEGPKHPTGPFFPVLSKDE 545
               VS              +   S SSK    ++P+    +     P     P      
Sbjct: 631 PKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRA 690

Query: 546 STALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQG 605
                 P  +     + P    S +P       S     R   T +PK I  ++    Q 
Sbjct: 691 PQTSSSPPPVRRGASSSPQRRQSPSP-------STRPIRRVSRTPEPKKIKKAASPSPQS 743

Query: 606 LDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSK 665
           +     ++S     E   +          S S  +  +   P     S T        S 
Sbjct: 744 VRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSD 803

Query: 666 KERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKA 702
           +E  GK  + KK KKHKK  KHK KHK   +EK+  A
Sbjct: 804 QEGGGKKKKKKKDKKHKKDKKHK-KHKKHKKEKAVAA 839



 Score = 38.9 bits (89), Expect = 0.038
 Identities = 51/261 (19%), Positives = 99/261 (37%), Gaps = 25/261 (9%)

Query: 632 APASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKH 691
           +P +      L+ +   GS  S +    RS P   +R   S R +  +        +R  
Sbjct: 646 SPVTKRRSPSLSSKHRKGSSPSRSTREARS-PQPNKRHSPSPRPRAPQTSSSPPPVRRGA 704

Query: 692 KADTEEKSSKAESGEK----SKKRKKRKRKKNKSSAPADSER-------GPKPEPPGSGS 740
            +  + + S + S       S+  + +K KK  S +P    R          PEP     
Sbjct: 705 SSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKP 764

Query: 741 PAPPRR-RRRAQDDSQRRSLPAEEGSSG--------KKDEGGGGSSSQDHGGRKHKGELP 791
           PAPP   + ++   +   ++P ++  S           D+ GGG   +    +KHK +  
Sbjct: 765 PAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKK 824

Query: 792 PSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSR 851
               ++    K  + ++  +   +    +  A++  L Q+ P    E ++E +S +E + 
Sbjct: 825 HKKHKKHKKEKAVAAAAAAAVTPA----AIAAATTTLAQEEPVAAPEPKKETESEAEDNL 880

Query: 852 SRSRSGRRHSSHRSSRRSYSS 872
                  R  + RS R++  S
Sbjct: 881 DDLEKHLREKALRSMRKAQVS 901


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
            sapiens]
          Length = 600

 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 77/386 (19%), Positives = 143/386 (37%), Gaps = 27/386 (6%)

Query: 657  DTGRSLPSKKE---RSGKSHRHKK-----KKKHKKSSKHKRKHKADTEEKSSKAESGEKS 708
            D  R  P  +E   R G    HK      ++++++  + +R+ K  TE         E  
Sbjct: 25   DFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTER--------ETD 76

Query: 709  KKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGK 768
            +KR++R+ K          ER    E          R R+R ++ ++++    E      
Sbjct: 77   RKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERE-----T 131

Query: 769  KDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRL 828
            + EG  G   Q  G R+ + +      + R   +   R + R++    + + +       
Sbjct: 132  EREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRER 191

Query: 829  HQKSPSQYSEEEEEEDSGSEHSRSR-----SRSGRRHSSHRSSRRSYSSSSDASSDQSCY 883
             ++   +   E+   + G E  R R     +   R+    R  +R      +  +++   
Sbjct: 192  ERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERA 251

Query: 884  SRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSR 943
            S + +  D       DR R   +R  + +       + R++R + +    +      + R
Sbjct: 252  SERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERER 311

Query: 944  SRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRS 1003
             R+R   RER R R R R     R R K R R     + +  R  +R   R  R  ++R 
Sbjct: 312  ERNRKRERERERERERERQRETERDREKERERKRKRQT-EMDRERNRQTGREGRRQAERE 370

Query: 1004 GSRKRSWGHESPEERHSGRRDFIRSK 1029
              R+R    +S  ER    RD  R +
Sbjct: 371  RERERERDRQSAREREERERDRDRDR 396



 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 90/480 (18%), Positives = 177/480 (36%), Gaps = 44/480 (9%)

Query: 652  GSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKR 711
            GS+     R L    + +    R + ++K ++  + KR+ + +T+ K  +    EK + R
Sbjct: 32   GSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRR--EKDRHR 89

Query: 712  KKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDE 771
            K+ + ++ +     + ER    E          R R+R ++ ++++    E    G++  
Sbjct: 90   KRDRHRERQRDREKERERQTDRE----------RDRQREKERNRQKERERETEREGER-- 137

Query: 772  GGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQK 831
               G   Q  G R+ + +      + R   +   R + R++    + + +     +  ++
Sbjct: 138  ---GRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKN----RQERRE 190

Query: 832  SPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSD 891
               Q  +E + ED  SE  R R R   R +   + R+  +        ++   R++    
Sbjct: 191  RERQREKENKTEDRHSERGRERERE--RETETETERKRQTDRERDRQRKTEREREKQAER 248

Query: 892  DSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTR 951
            +  S+      +  +R  D D       + R +R K      D        R R     R
Sbjct: 249  ERASERETERDKERERERDRD-------RDRDRRQKERERQTDRKRQRRTERDRETERKR 301

Query: 952  ERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWG 1011
            ER R R R R  +  R R + R R       +R R   RDR +      +R   RKR   
Sbjct: 302  ERQRERERERERNRKRERERERERER-----ERQRETERDREK------ERERKRKRQTE 350

Query: 1012 HESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIG 1071
             +    R +GR    +++  R +     R    E   ++ D   D  K     ++    G
Sbjct: 351  MDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDG 410

Query: 1072 ---TGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPNKAGPKLKDPPQ 1128
               T +  E +   E +         EK + R+ +R+     +      ++   +  PP+
Sbjct: 411  QRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPR 470



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 74/406 (18%), Positives = 154/406 (37%), Gaps = 31/406 (7%)

Query: 643  NKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKA 702
            N+Q+          + GR   +  +R  +  R  +K++ +++ + +++      +K  + 
Sbjct: 122  NRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKERER 181

Query: 703  ESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAE 762
            E   + ++ ++R+R+K   +    SERG + E          R+R+  ++  ++R    E
Sbjct: 182  EKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTERE 241

Query: 763  EGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDD 822
                 +++      + +D   ++ + E      + R   +R  ++  + Q  +  +   +
Sbjct: 242  REKQAERERASERETERD---KERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETE 298

Query: 823  ASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRR-HSSHRSSRRSYSSSSDASSDQS 881
                R  ++   +    + E +   E  R R R   R     R  +R   +  D   ++ 
Sbjct: 299  RKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQ 358

Query: 882  CYSRQRSYSDDSYSDYSDRSRRHSKRSHDSD-DSDYASSKHRSKRHKYSSSDDDYSLSCS 940
                 R  ++       +R R+ ++   + + D D    K R ++   +  D D      
Sbjct: 359  TGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQ---TEKDRDGQRETE 415

Query: 941  QSRSRSRSHT----RERSRS------RGRSRSSSCSRSRSKRRSRST----TAHSWQRSR 986
            + R R +       RER R       R R R     R   ++R RST          RS 
Sbjct: 416  KQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSG 475

Query: 987  SYSRDRSRSTR------SPSQ-RSGSRKRSWGH--ESPEERHSGRR 1023
                D +R TR      SP   ++ S +  WG   ++   R +GRR
Sbjct: 476  VVQSDPNRPTRGIRWKSSPEDPKAASTRFPWGRPAKASRGRVAGRR 521



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 48/200 (24%), Positives = 71/200 (35%), Gaps = 19/200 (9%)

Query: 852  SRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDS 911
            SR R G + S  R  R    +  DA  D    +RQ+           +R RR  KR  + 
Sbjct: 27   SRRRPGSQESPRR--RGLGQAHKDADGDDRERNRQK-----------ERERRREKRQTER 73

Query: 912  DDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSK 971
            +       +    RH+      +      + R R     R+R R + R+R     R   +
Sbjct: 74   ETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETER 133

Query: 972  R----RSRSTTA-HSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGR-RDF 1025
                 R R T      +R R   ++R R T    QR   R R    E  + R   R R+ 
Sbjct: 134  EGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERER 193

Query: 1026 IRSKIYRSQSPHYFRSGRGE 1045
             R K  +++  H  R    E
Sbjct: 194  QREKENKTEDRHSERGRERE 213



 Score = 34.3 bits (77), Expect = 0.93
 Identities = 32/115 (27%), Positives = 45/115 (39%), Gaps = 8/115 (6%)

Query: 944  SRSRSHTRERSRSRGRSRS------SSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTR 997
            SR R  ++E  R RG  ++          R+R K R R       +R     R+R R   
Sbjct: 27   SRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKD 86

Query: 998  SPSQRSGSRKRSWGHESPEERHSGR-RDFIRSKIYRSQSPHYFRSGRGEGPGKKD 1051
               +R   R+R    E   ER + R RD  R K  R++     R    EG   +D
Sbjct: 87   RHRKRDRHRERQRDREKERERQTDRERDRQREK-ERNRQKERERETEREGERGRD 140



 Score = 32.7 bits (73), Expect = 2.7
 Identities = 25/114 (21%), Positives = 52/114 (45%), Gaps = 15/114 (13%)

Query: 92  EDATERRRVLEVEKEDTEELRQKYKDYVDKEKAIAKALEDLRANFYCELCDKQYQKHQEF 151
           E  TER+R  + E++   +  ++ +   ++E+A  +  E           DK+ ++ ++ 
Sbjct: 219 ETETERKRQTDRERDRQRKTEREREKQAERERASERETER----------DKERERERDR 268

Query: 152 DNHINSYDHAHKQRLKDLKQREFARNVSSRSRKDEKKQEKALRRLHELAEQRKQ 205
           D      D   K+R +   ++   R  + R R+ E+K+E+   R  E    RK+
Sbjct: 269 D---RDRDRRQKERERQTDRKRQRR--TERDRETERKRERQRERERERERNRKR 317


>gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]
          Length = 1462

 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 110/413 (26%), Positives = 156/413 (37%), Gaps = 63/413 (15%)

Query: 644  KQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHK-----KSSKHKRKHKADTEEK 698
            +++P  S GS++     S       S   H   +++KHK     K SK +RK  + +EE 
Sbjct: 189  RKKPTHSEGSDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSEEP 248

Query: 699  SSK--------AESGEKSKKRKKRKRKKNKSSAPADSERGPKPE---------PPGSGSP 741
             +K        +E  + ++KR      K +       E  P PE         P  +  P
Sbjct: 249  RNKHAMNPKGHSERSDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLRRDMPVVTAEP 308

Query: 742  APPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGG--------SSSQDHGGRKHKGELPPS 793
             P           Q+ S+      SG+K +G G         S S          E PP 
Sbjct: 309  EPKIPDVAPIVSDQKPSV----SKSGRKIKGRGTIRYHTPPRSRSCSESDDDDSSETPPH 364

Query: 794  SCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSH----RLHQKSPS-----QYSEEEEEED 844
              +      R+ R     + S GD+ SD  SS      L Q+S S      YS+      
Sbjct: 365  -WKEEMQRLRAYRPPSGEKWSKGDKLSDPCSSRWDERSLSQRSRSWSYNGYYSDLSTARH 423

Query: 845  SGSEHSRSRSRSG------------RRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDD 892
            SG    R + +              RRH   ++ +R     SD  S +S   R +S  D 
Sbjct: 424  SGHHKKRRKEKKVKHKKKGKKQKHCRRHK--QTKKRRILIPSDIESSKSSTRRMKSSCDR 481

Query: 893  SYSDYSDRSRRH--SKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHT 950
              S  S     H  SKR     D D  SS   S R  Y S     S S   SRSR+ S +
Sbjct: 482  ERSSRSSSLSSHHSSKRDWSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRTASKS 541

Query: 951  RERSRSRGRSRSSSCSRSRSKRRSRS--TTAHSWQRSRSYSRDRSRSTRSPSQ 1001
               SRSR +SRSSS S  R KR S+S   TA     ++    +  R+T + ++
Sbjct: 542  SSHSRSRSKSRSSSKSGHR-KRASKSPRKTASQLSENKPVKTEPLRATMAQNE 593



 Score = 84.3 bits (207), Expect = 8e-16
 Identities = 132/515 (25%), Positives = 187/515 (36%), Gaps = 93/515 (18%)

Query: 674  RHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKP 733
            + +KK  H + S       + +E  S      E+S++RK ++R K K S     E     
Sbjct: 187  KKRKKPTHSEGSDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSE 246

Query: 734  EP-------PGSGSPAPPRRRRRAQDDSQRRSLPA---EE-------------------- 763
            EP       P   S       +R+ D S +R  P    EE                    
Sbjct: 247  EPRNKHAMNPKGHSERSDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLRRDMPVVTA 306

Query: 764  --------------------GSSGKKDEGGG--------GSSSQDHGGRKHKGELPPSSC 795
                                  SG+K +G G         S S          E PP   
Sbjct: 307  EPEPKIPDVAPIVSDQKPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDSSETPP-HW 365

Query: 796  QRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSR 855
            +      R+ R     + S GD+ SD  SS R  ++S SQ S       S S +      
Sbjct: 366  KEEMQRLRAYRPPSGEKWSKGDKLSDPCSS-RWDERSLSQRSR------SWSYNGYYSDL 418

Query: 856  SGRRHSSHRSSRR---SYSSSSDASSDQSC----YSRQRSYSDDSYSDYSDRSRRHSKRS 908
            S  RHS H   RR              + C     +++R     S  + S  S R  K S
Sbjct: 419  STARHSGHHKKRRKEKKVKHKKKGKKQKHCRRHKQTKKRRILIPSDIESSKSSTRRMKSS 478

Query: 909  HDSDDSDYAS--SKHRSKRHKYSSSDDDYSLSCS-------QSRSRSRSHTRERSRSRGR 959
             D + S  +S  S H S +  +S SD D   S +       +S+S S+S++R  SRSR  
Sbjct: 479  CDRERSSRSSSLSSHHSSKRDWSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRTA 538

Query: 960  SRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSR-STRSPSQRSGSRKRSWGHESPEER 1018
            S+SSS SRSRSK RS S + H  + S+S  +  S+ S   P +    R     +E+   +
Sbjct: 539  SKSSSHSRSRSKSRSSSKSGHRKRASKSPRKTASQLSENKPVKTEPLRATMAQNENVVVQ 598

Query: 1019 HSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGP---PSQN----SNIG 1071
                 +     I  S SP   R   G+ P K    R  + KA      P Q+    +NI 
Sbjct: 599  PVVAENI--PVIPLSDSPPPSRWKPGQKPWKPSYERIQEMKAKTTHLLPIQSTYSLANI- 655

Query: 1072 TGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKP 1106
               GS       +KNS + +    K   R  E  P
Sbjct: 656  KETGSSSSYHKREKNSESDQSTYSKYSDRSSESSP 690



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 168/771 (21%), Positives = 284/771 (36%), Gaps = 146/771 (18%)

Query: 429  KNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSEPGSKAEAKKALGG 488
            +  P   +GS     S   +++S+ + ++  E     +      P    SK   K+A   
Sbjct: 189  RKKPTHSEGSDSSSNS---SSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSS 245

Query: 489  DVSDQ----SLESHSQK--VSETQMCESNSSKETSLATPAGKESQEGPKHPTGPFF---- 538
            +        + + HS++   +E +  +S++ +E  +  P     +E P  P   F     
Sbjct: 246  EEPRNKHAMNPKGHSERSDTNEKRSVDSSAKREKPVVRP-----EEIPPVPENRFLLRRD 300

Query: 539  -PVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTKGTEKPKDIGS 597
             PV++ +    +  P    I +  +PS+S S   +     +  +   R++   +  D  S
Sbjct: 301  MPVVTAEPEPKI--PDVAPIVSDQKPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDS 358

Query: 598  SS-----KDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGS----ACSGLNKQEPG 648
            S      K+ +Q L    P       GEK   S G ++  P S      + S  ++    
Sbjct: 359  SETPPHWKEEMQRLRAYRPPS-----GEKW--SKGDKLSDPCSSRWDERSLSQRSRSWSY 411

Query: 649  GSHGSETEDTGRSLPSKKERSGKSHRHKKK-KKHKKSSKHKRKHK------ADTEEKSSK 701
              + S+      S   KK R  K  +HKKK KK K   +HK+  K      +D E   S 
Sbjct: 412  NGYYSDLSTARHSGHHKKRRKEKKVKHKKKGKKQKHCRRHKQTKKRRILIPSDIESSKSS 471

Query: 702  AESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRR-RAQDDSQR---- 756
                + S  R++  R  + SS  +      K +     S     R   R++  SQ     
Sbjct: 472  TRRMKSSCDRERSSRSSSLSSHHSSKRDWSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRG 531

Query: 757  --RSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPS 814
              RS  A + SS  +      SSS+  G RK   + P  +  + +  K       R+  +
Sbjct: 532  SSRSRTASKSSSHSRSRSKSRSSSKS-GHRKRASKSPRKTASQLSENKPVKTEPLRATMA 590

Query: 815  SGDED------SDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRR 868
              +        +++     L    P    +  ++    S       ++   H     S  
Sbjct: 591  QNENVVVQPVVAENIPVIPLSDSPPPSRWKPGQKPWKPSYERIQEMKAKTTHLLPIQSTY 650

Query: 869  SYSSSSDASSDQSCYSRQRSYSDD--SYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRH 926
            S ++  +  S  S + R+++   D  +YS YSDRS   S RS         SS+ RS   
Sbjct: 651  SLANIKETGSSSSYHKREKNSESDQSTYSKYSDRSSESSPRSRSR------SSRSRS--- 701

Query: 927  KYSSSDDDYSLSCSQSRSRSRSHTRERS-RSRGRSRS-----SSCSRS------------ 968
                    YS S ++SRS + SH+R RS  SR  SR+     S CSRS            
Sbjct: 702  --------YSRSYTRSRSLASSHSRSRSPSSRSHSRNKYSDHSQCSRSSSYTSISSDDGR 753

Query: 969  RSKRRSRST-----------------TAHS--------------WQRSRS---YSRDRSR 994
            R+KRR RS+                 T HS              +  SRS   YS D  +
Sbjct: 754  RAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQ 813

Query: 995  STRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPH------------YFRSG 1042
            S+   +Q +  +++    E    +    R   +SK  R + PH            + R+G
Sbjct: 814  SSVQATQSAQEKEKQGQMERTHNKQEKNRGEEKSKSER-ECPHSKKRTLKENLSDHLRNG 872

Query: 1043 ----RGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVT 1089
                R    G K D   +  +     S+N +  +    EG+ + + ++ V+
Sbjct: 873  SKPKRKNYAGSKWDSESNSERDVTKNSKNDSHPSSDKEEGEATSDSESEVS 923



 Score = 74.3 bits (181), Expect = 8e-13
 Identities = 75/221 (33%), Positives = 104/221 (47%), Gaps = 27/221 (12%)

Query: 800  GTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRR 859
            G +   +S ++ +P S  ++    +  RL+++  +Q S  +E+  S  + S+SRS S  R
Sbjct: 1261 GLRIEIKSKNKVRPGSLFDEVRKTA--RLNRRPRNQESSSDEQTPSRDDDSQSRSPSRSR 1318

Query: 860  HSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASS 919
              S   SR    S S        YS  RS S  S S Y  RS   S+         Y+  
Sbjct: 1319 SKSETKSRHRTRSVS--------YSHSRSRSRSSTSSYRSRSYSRSRSR-----GWYSRG 1365

Query: 920  KHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRE-RSRSRGRSRSSSCSRSRSKRRSRSTT 978
            + RS+   Y S    Y    + SRSRSRS + +  SRSR  +  S  SRSRS    RS +
Sbjct: 1366 RTRSRSSSYRS----YKSHRTSSRSRSRSSSYDPHSRSRSYTYDSYYSRSRS----RSRS 1417

Query: 979  --AHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEE 1017
              + S+ R RSY+R RSRS RS    S S +    H SP E
Sbjct: 1418 QRSDSYHRGRSYNR-RSRSCRSYGSDSESDRSYSHHRSPSE 1457



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 70/194 (36%), Positives = 92/194 (47%), Gaps = 39/194 (20%)

Query: 850  SRSRSRSGRRHSSHRSSRR--SYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKR 907
            S+++ R G      R + R      + ++SSD+   SR     DDS S    RSR  S+ 
Sbjct: 1268 SKNKVRPGSLFDEVRKTARLNRRPRNQESSSDEQTPSRD----DDSQSRSPSRSRSKSE- 1322

Query: 908  SHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRER---SRSRGRSRSSS 964
                       S+HR++   YS S      S S  RSRS S +R R   SR R RSRSSS
Sbjct: 1323 ---------TKSRHRTRSVSYSHSRSRSRSSTSSYRSRSYSRSRSRGWYSRGRTRSRSSS 1373

Query: 965  -----CSRSRSKRRSRSTTAHSWQRSRSY--------SRDRSRSTRSPSQ---RSGSRK- 1007
                   R+ S+ RSRS++     RSRSY        SR RSRS RS S    RS +R+ 
Sbjct: 1374 YRSYKSHRTSSRSRSRSSSYDPHSRSRSYTYDSYYSRSRSRSRSQRSDSYHRGRSYNRRS 1433

Query: 1008 ---RSWGHESPEER 1018
               RS+G +S  +R
Sbjct: 1434 RSCRSYGSDSESDR 1447



 Score = 67.8 bits (164), Expect = 8e-11
 Identities = 58/177 (32%), Positives = 85/177 (48%), Gaps = 16/177 (9%)

Query: 921  HRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAH 980
            +R  R++ SSSD+        S+SRS S +R +S ++ R R+ S S S S+ RSRS+T  
Sbjct: 1288 NRRPRNQESSSDEQTPSRDDDSQSRSPSRSRSKSETKSRHRTRSVSYSHSRSRSRSST-- 1345

Query: 981  SWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIY----RSQS- 1035
            S  RSRSYSR RSR   S   R  +R RS  + S +   +  R   RS  Y    RS+S 
Sbjct: 1346 SSYRSRSYSRSRSRGWYS---RGRTRSRSSSYRSYKSHRTSSRSRSRSSSYDPHSRSRSY 1402

Query: 1036 --PHYFRSGRGEGPGKKDD----GRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKN 1086
                Y+   R     ++ D    GR  + ++    S  S+  + R      SP + +
Sbjct: 1403 TYDSYYSRSRSRSRSQRSDSYHRGRSYNRRSRSCRSYGSDSESDRSYSHHRSPSESS 1459



 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 89/427 (20%), Positives = 150/427 (35%), Gaps = 65/427 (15%)

Query: 661  SLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNK 720
            SL + KE    S  HK++K  +       K+   + E S ++ S     +   R   +++
Sbjct: 651  SLANIKETGSSSSYHKREKNSESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSR 710

Query: 721  SSAPADSERGPKPEPPGSGSPAPPRRRRRAQ--DDSQRRSLPAEEG--------SSGKKD 770
            S A + S    +   P S S +  +    +Q    S   S+ +++G        SSGKK+
Sbjct: 711  SLASSHS----RSRSPSSRSHSRNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKN 766

Query: 771  EGGG---GSSSQDHGGRKHKGELPPSSCQRRAGTKRSSR--SSHRSQPS-----SGDEDS 820
                    SSS+     K+      SSC R+    RSS   SS   Q S     S  E  
Sbjct: 767  SVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKE 826

Query: 821  DDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSR-------------------SRSGRRHS 861
                  R H K      EE+ + +    HS+ R                   + +G +  
Sbjct: 827  KQGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWD 886

Query: 862  SHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKH 921
            S  +S R  + +S   S  S    +   + DS S+ S+   +    +  S ++       
Sbjct: 887  SESNSERDVTKNSKNDSHPSSDKEEGEATSDSESEVSEIHIKVKPTTKSSTNTSLPDDNG 946

Query: 922  RSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHS 981
              K  K  +S  D   SCS S +      + +  S+   +     + + K + +    H 
Sbjct: 947  AWKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKLKGKKDKKHK 1006

Query: 982  ---------WQRSRSYSRDRSR--STRSPSQRSGSRKRSWGHE-----------SPEERH 1019
                     WQ    +  +       +  +Q S  +K S  +E           S EE  
Sbjct: 1007 APKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSEEDL 1066

Query: 1020 SGRRDFI 1026
            SG+ D +
Sbjct: 1067 SGKHDTV 1073



 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 144/665 (21%), Positives = 242/665 (36%), Gaps = 117/665 (17%)

Query: 330  DGTKPDEKSSDQGLQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGAGAT 389
            +G+KP  K+         DS+ +S  D  K  ++     S            +EEG   +
Sbjct: 871  NGSKPKRKNY---AGSKWDSESNSERDVTKNSKNDSHPSS-----------DKEEGEATS 916

Query: 390  EPEYYHYIPPAHCKVKPNFPFLL----------FMRASEQMDGDNTTHPKNAPESKKGSS 439
            + E    +   H KVKP                +  + ++    ++    +  E+ +G  
Sbjct: 917  DSE--SEVSEIHIKVKPTTKSSTNTSLPDDNGAWKSSKQRTSTSDSEGSCSNSENNRGKP 974

Query: 440  PKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSEPGSKAEAKKALGGDVSDQSLESH- 498
             K K   K    +   K V E  +  K+     P    +         G+  ++ ++   
Sbjct: 975  QKHKHGSKENLKREHTKKVKEKLKGKKDKKHKAPKRKQAFHWQPPLEFGEEEEEEIDDKQ 1034

Query: 499  -SQKVSETQMCESNSS-KETSLATPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELL 556
             +Q+  E ++ E+N + K+  L T    E     KH T              +   S+L 
Sbjct: 1035 VTQESKEKKVSENNETIKDNILKTEKSSEEDLSGKHDT--------------VTVSSDLD 1080

Query: 557  IFTKAEPSISYSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKE 616
             FTK +  +S S   L                TE+      +   ++Q ++   PN    
Sbjct: 1081 QFTKDDSKLSISPTAL---------------NTEE----NVACLQNIQHVEESVPN---- 1117

Query: 617  VGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHK 676
             G E ++++           S+ + + +  P G+   +T D    L  K++ + +  + +
Sbjct: 1118 -GVEDVLQTDDNMEICTPDRSSPAKVEETSPLGNARLDTPDINIVL--KQDMATEHPQAE 1174

Query: 677  KKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPP 736
              K+    S+ K   +   ++ SS + +       KK   +K++ +   D +  P     
Sbjct: 1175 VVKQESSMSESKVLGEVGKQDSSSASLASAGESTGKKEVAEKSQINL-IDKKWKPLQ--- 1230

Query: 737  GSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSC- 795
            G G+ A P     +  + +  +   E    G + E             K K ++ P S  
Sbjct: 1231 GVGNLAAPNAATSSAVEVKVLTTVPEMKPQGLRIE------------IKSKNKVRPGSLF 1278

Query: 796  ------QRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQ---------YSEEE 840
                   R     R+  SS   Q  S D+DS   S  R   KS ++         YS   
Sbjct: 1279 DEVRKTARLNRRPRNQESSSDEQTPSRDDDSQSRSPSRSRSKSETKSRHRTRSVSYSHSR 1338

Query: 841  EEEDSGSEHSRSRSRS----------GR---RHSSHRS--SRRSYSSSSDASSDQSCYSR 885
                S +   RSRS S          GR   R SS+RS  S R+ S S   SS    +SR
Sbjct: 1339 SRSRSSTSSYRSRSYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSSRSRSRSSSYDPHSR 1398

Query: 886  QRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSR 945
             RSY+ DSY   S RSR  S+RS         + + RS R   S S+ D S S  +S S 
Sbjct: 1399 SRSYTYDSYYSRS-RSRSRSQRSDSYHRGRSYNRRSRSCRSYGSDSESDRSYSHHRSPSE 1457

Query: 946  SRSHT 950
            S  ++
Sbjct: 1458 SSRYS 1462



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 61/228 (26%), Positives = 82/228 (35%), Gaps = 46/228 (20%)

Query: 922  RSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHS 981
            + K+  +S   D  S S S S S S S   E  RSR R         RSK+R +  ++  
Sbjct: 188  KRKKPTHSEGSDSSSNSSSSSESSSESEL-EHERSRRRKHKRRPKVKRSKKRRKEASSSE 246

Query: 982  WQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHES-----------PEERHSGRRDF----- 1025
              R++     +  S RS +    S   S   E            PE R   RRD      
Sbjct: 247  EPRNKHAMNPKGHSERSDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLRRDMPVVTA 306

Query: 1026 -------IRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEG 1078
                     + I   Q P   +SGR      K  GRG     T P S++        SE 
Sbjct: 307  EPEPKIPDVAPIVSDQKPSVSKSGR------KIKGRGTIRYHTPPRSRSC-------SES 353

Query: 1079 DCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPNKAGPKLKDP 1126
            D   +D +S T     E++Q  +  R PS  +         G KL DP
Sbjct: 354  D---DDDSSETPPHWKEEMQRLRAYRPPSGEKW------SKGDKLSDP 392


>gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sapiens]
          Length = 805

 Score = 88.2 bits (217), Expect = 5e-17
 Identities = 99/373 (26%), Positives = 156/373 (41%), Gaps = 44/373 (11%)

Query: 786  HKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQK--SPSQYSEE-EEE 842
            H  ++     Q    TK  +   H+ Q S    ++ +A    +++K  +P++ +   E +
Sbjct: 437  HDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPK 496

Query: 843  EDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSR 902
            ++   +  + RSRSG   S   SS    SS+S   S  S  S   S    S S    R +
Sbjct: 497  KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKK 556

Query: 903  RHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSL---------SCSQSRSRSRSHTRER 953
            RHS+    +  +  + S+  S+R K  S+     +         S  + R R+RS +RER
Sbjct: 557  RHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRER 616

Query: 954  SRSRGRS---RSSSCSRSRSKRRSR--------STTAHSW-----------QRSRSYSRD 991
             RSR RS   R++  SRSRS+ R +        S  +H             +RSRS  +D
Sbjct: 617  RRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKD 676

Query: 992  RSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKD 1051
            R +  +   +    RK     E  + + S + D ++ K  R     + RSG       + 
Sbjct: 677  RKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRK--RESERTFSRSGSISVKIIRH 734

Query: 1052 DGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEE 1111
            D R D  K+T   +++S   +G  S G  S E   S   K    K +  K  R  SV E+
Sbjct: 735  DSRQDSKKST---TKDSKKHSGSDSSGRSSSESPGSSKEK----KAKKPKHSRSRSV-EK 786

Query: 1112 VQATPNKAGPKLK 1124
             Q +  KA  K K
Sbjct: 787  SQRSGKKASRKHK 799



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 77/332 (23%), Positives = 132/332 (39%), Gaps = 27/332 (8%)

Query: 611 PNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTG--RSLPSKKER 668
           PN++  V   K       +     SGS+ SG +      S  S T  +    S       
Sbjct: 486 PNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRT 545

Query: 669 SGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKK--RKRKKNKSSAPAD 726
           S +S   K+KK+H +S     K +       S+    E ++ R K   +R+ N++S   +
Sbjct: 546 SSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERE 605

Query: 727 SERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKK--DEGGGGSSSQDHGGR 784
             R        + SP+  RRR R++   +R +  +   S  ++  D+  G  S   H   
Sbjct: 606 RRR--------NRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSH--- 654

Query: 785 KHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEED 844
           KHKGE      +R+    RS     + +    + + D     +  ++   ++S +++   
Sbjct: 655 KHKGEAKEQ--ERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLK 712

Query: 845 SGSEHSRSRSRSGR------RHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYS 898
              E  R+ SRSG       RH S + S++S +  S   S      R  S S  S  +  
Sbjct: 713 RKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKK 772

Query: 899 DRSRRHSKRSHDSDDSDYASSKHRSKRHKYSS 930
            +  +HS+    S +    S K  S++HK  S
Sbjct: 773 AKKPKHSRSR--SVEKSQRSGKKASRKHKSKS 802



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 136/618 (22%), Positives = 229/618 (37%), Gaps = 111/618 (17%)

Query: 452  QGAEKTVSEVSEQPKETSMTEPSEPGSKAEAKK---ALGGD---VSDQSLESHSQKVSET 505
            +G EK   E  ++ ++  M +     SK E K    A GGD   +  +S     ++  +T
Sbjct: 238  EGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDT 297

Query: 506  QMCESNSS-KETSLATPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTK---A 561
            +  E+ SS K T   +P  +E    P              E T  +   ++++ TK    
Sbjct: 298  ENVEAASSGKVTRSPSPVPQEEHSDP--------------EMTEEEKEYQMMLLTKMLLT 343

Query: 562  EPSISYSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEK 621
            E  +  +   +Y+  K     DA  K T+ P                     +K++    
Sbjct: 344  EILLDVTDEEIYYVAK-----DAHRKATKAP---------------------AKQLAQSS 377

Query: 622  IVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTG--RSLPSKKERSGKSHRHKKKK 679
             + S  G       GS  S  +++   GS  S+T+D      +  K+E   +  + ++  
Sbjct: 378  ALASLTGLGGLGGYGSGDSE-DERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLL 436

Query: 680  KHKKSSKHKRKHKADTEEKSSKAESGEKSKKR-----------KKRKRKKNKSSAPADSE 728
              K+  + K++ +  T+E +      + S               ++KR  N++++  + +
Sbjct: 437  HDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPK 496

Query: 729  RGPKPEPP------GSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHG 782
            +  K +        GS S        R    S   S  +   SSG        SS +   
Sbjct: 497  KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRK- 555

Query: 783  GRKHKGELPPSSCQRRAGTKRSSR----SSHRSQPSSGDEDSDDASS---HRLHQKSPSQ 835
             ++H     P+   RR+ ++  SR     S+R++    D    + +S    R   +SPS+
Sbjct: 556  -KRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSR 614

Query: 836  Y---SEEEEEEDSGSEHSRSRSRSGRRHSSHRS--SRRSYSSSSDASSDQSCYSRQRSYS 890
                S     +   +  SRSRSR  R+    R   S  S+    +A   +    R RS  
Sbjct: 615  ERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSID 674

Query: 891  DDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDD----------DYSLSCS 940
             D      +R R   KR            K   K  K+SS DD           +S S S
Sbjct: 675  KDRKKKDKEREREQDKRKE--------KQKREEKDFKFSSQDDRLKRKRESERTFSRSGS 726

Query: 941  --------QSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDR 992
                     SR  S+  T + S+    S SS  S S S   S+   A   + SRS S ++
Sbjct: 727  ISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEK 786

Query: 993  S-RSTRSPSQRSGSRKRS 1009
            S RS +  S++  S+ RS
Sbjct: 787  SQRSGKKASRKHKSKSRS 804



 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 69/321 (21%), Positives = 124/321 (38%), Gaps = 16/321 (4%)

Query: 676 KKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEP 735
           K+ K+ +K  + +    +     S+   S   S          + SS  +     PK + 
Sbjct: 497 KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKK 556

Query: 736 PGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSC 795
             S S +P  + RR++  S  R +  E   +  K      S+       + +   P    
Sbjct: 557 RHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRER 616

Query: 796 QRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSR 855
           +R     R  R++  S+  S D    D     L   S  ++  E +E++   E SRS  +
Sbjct: 617 RRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNS-HKHKGEAKEQERKKERSRSIDK 675

Query: 856 SGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSD 915
             ++    R          +   D+    ++R   D  +S   DR +R  +       S 
Sbjct: 676 DRKKKDKER----------EREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSG 725

Query: 916 YASSK---HRSKR-HKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSK 971
             S K   H S++  K S++ D    S S S  RS S +   S+ + +++    SRSRS 
Sbjct: 726 SISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEK-KAKKPKHSRSRSV 784

Query: 972 RRSRSTTAHSWQRSRSYSRDR 992
            +S+ +   + ++ +S SR R
Sbjct: 785 EKSQRSGKKASRKHKSKSRSR 805



 Score = 44.7 bits (104), Expect = 7e-04
 Identities = 45/192 (23%), Positives = 73/192 (38%), Gaps = 15/192 (7%)

Query: 664 SKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSA 723
           ++  RS    R K   +    S +  KHK + +E+  K E      K +K+K K+ +   
Sbjct: 629 NRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQ 688

Query: 724 PADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGG 783
               E+  + E     S         +QDD  +R   +E   S     G        H  
Sbjct: 689 DKRKEKQKREEKDFKFS---------SQDDRLKRKRESERTFS---RSGSISVKIIRHDS 736

Query: 784 RKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEE 843
           R+   +      ++ +G+  S RSS  S  SS ++ +      R      SQ S ++   
Sbjct: 737 RQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKA-- 794

Query: 844 DSGSEHSRSRSR 855
            S    S+SRSR
Sbjct: 795 -SRKHKSKSRSR 805



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 86/402 (21%), Positives = 140/402 (34%), Gaps = 109/402 (27%)

Query: 732  KPEPPGSGSPAPPRRRRRAQ----------------------DDSQRRSLPA------EE 763
            +P PPG   PAPP+ RR                         D  +RR+LPA      E+
Sbjct: 185  QPGPPGP--PAPPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEK 242

Query: 764  GSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDA 823
                K+ +       Q       K +      +   G +   RS   S     D ++ +A
Sbjct: 243  MEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEA 302

Query: 824  SSHRLHQKSPSQYSEEEEEEDSGSEHS--------------------------------- 850
            +S     +SPS   +EE  +   +E                                   
Sbjct: 303  ASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAH 362

Query: 851  RSRSRSGRRHSSHRSSRRSYS--------SSSDASSDQSCYSRQRSYSDDSYSDYSDRSR 902
            R  +++  +  +  S+  S +         S D+  ++S    + S +DD    +  R +
Sbjct: 363  RKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQK 422

Query: 903  -----RHSKRSHDSDDSDYASSKHRSKRHKYSSSD----DDYSLSCSQSRSRSRSHTRER 953
                 R  K      D      K +++R     ++    +  SLS  ++R        E+
Sbjct: 423  QEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEK 482

Query: 954  SRS-------------------RGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSR 994
             R+                   +GRSRS S S   S   SR+++  S   S SYS   S 
Sbjct: 483  KRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYS-SSSG 541

Query: 995  STRSPSQRSGSRKRSWGHESPEERHS-GRRDFIRSKIYRSQS 1035
            S+R+ S RS S KR       ++RHS  R   I+++  RS+S
Sbjct: 542  SSRT-SSRSSSPKR-------KKRHSRSRSPTIKARRSRSRS 575


>gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sapiens]
          Length = 805

 Score = 88.2 bits (217), Expect = 5e-17
 Identities = 99/373 (26%), Positives = 156/373 (41%), Gaps = 44/373 (11%)

Query: 786  HKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQK--SPSQYSEE-EEE 842
            H  ++     Q    TK  +   H+ Q S    ++ +A    +++K  +P++ +   E +
Sbjct: 437  HDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPK 496

Query: 843  EDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSR 902
            ++   +  + RSRSG   S   SS    SS+S   S  S  S   S    S S    R +
Sbjct: 497  KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKK 556

Query: 903  RHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSL---------SCSQSRSRSRSHTRER 953
            RHS+    +  +  + S+  S+R K  S+     +         S  + R R+RS +RER
Sbjct: 557  RHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRER 616

Query: 954  SRSRGRS---RSSSCSRSRSKRRSR--------STTAHSW-----------QRSRSYSRD 991
             RSR RS   R++  SRSRS+ R +        S  +H             +RSRS  +D
Sbjct: 617  RRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKD 676

Query: 992  RSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKD 1051
            R +  +   +    RK     E  + + S + D ++ K  R     + RSG       + 
Sbjct: 677  RKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRK--RESERTFSRSGSISVKIIRH 734

Query: 1052 DGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEE 1111
            D R D  K+T   +++S   +G  S G  S E   S   K    K +  K  R  SV E+
Sbjct: 735  DSRQDSKKST---TKDSKKHSGSDSSGRSSSESPGSSKEK----KAKKPKHSRSRSV-EK 786

Query: 1112 VQATPNKAGPKLK 1124
             Q +  KA  K K
Sbjct: 787  SQRSGKKASRKHK 799



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 77/332 (23%), Positives = 132/332 (39%), Gaps = 27/332 (8%)

Query: 611 PNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTG--RSLPSKKER 668
           PN++  V   K       +     SGS+ SG +      S  S T  +    S       
Sbjct: 486 PNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRT 545

Query: 669 SGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKK--RKRKKNKSSAPAD 726
           S +S   K+KK+H +S     K +       S+    E ++ R K   +R+ N++S   +
Sbjct: 546 SSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERE 605

Query: 727 SERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKK--DEGGGGSSSQDHGGR 784
             R        + SP+  RRR R++   +R +  +   S  ++  D+  G  S   H   
Sbjct: 606 RRR--------NRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSH--- 654

Query: 785 KHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEED 844
           KHKGE      +R+    RS     + +    + + D     +  ++   ++S +++   
Sbjct: 655 KHKGEAKEQ--ERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLK 712

Query: 845 SGSEHSRSRSRSGR------RHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYS 898
              E  R+ SRSG       RH S + S++S +  S   S      R  S S  S  +  
Sbjct: 713 RKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKK 772

Query: 899 DRSRRHSKRSHDSDDSDYASSKHRSKRHKYSS 930
            +  +HS+    S +    S K  S++HK  S
Sbjct: 773 AKKPKHSRSR--SVEKSQRSGKKASRKHKSKS 802



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 136/618 (22%), Positives = 229/618 (37%), Gaps = 111/618 (17%)

Query: 452  QGAEKTVSEVSEQPKETSMTEPSEPGSKAEAKK---ALGGD---VSDQSLESHSQKVSET 505
            +G EK   E  ++ ++  M +     SK E K    A GGD   +  +S     ++  +T
Sbjct: 238  EGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDT 297

Query: 506  QMCESNSS-KETSLATPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTK---A 561
            +  E+ SS K T   +P  +E    P              E T  +   ++++ TK    
Sbjct: 298  ENVEAASSGKVTRSPSPVPQEEHSDP--------------EMTEEEKEYQMMLLTKMLLT 343

Query: 562  EPSISYSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEK 621
            E  +  +   +Y+  K     DA  K T+ P                     +K++    
Sbjct: 344  EILLDVTDEEIYYVAK-----DAHRKATKAP---------------------AKQLAQSS 377

Query: 622  IVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTG--RSLPSKKERSGKSHRHKKKK 679
             + S  G       GS  S  +++   GS  S+T+D      +  K+E   +  + ++  
Sbjct: 378  ALASLTGLGGLGGYGSGDSE-DERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLL 436

Query: 680  KHKKSSKHKRKHKADTEEKSSKAESGEKSKKR-----------KKRKRKKNKSSAPADSE 728
              K+  + K++ +  T+E +      + S               ++KR  N++++  + +
Sbjct: 437  HDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPK 496

Query: 729  RGPKPEPP------GSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHG 782
            +  K +        GS S        R    S   S  +   SSG        SS +   
Sbjct: 497  KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRK- 555

Query: 783  GRKHKGELPPSSCQRRAGTKRSSR----SSHRSQPSSGDEDSDDASS---HRLHQKSPSQ 835
             ++H     P+   RR+ ++  SR     S+R++    D    + +S    R   +SPS+
Sbjct: 556  -KRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSR 614

Query: 836  Y---SEEEEEEDSGSEHSRSRSRSGRRHSSHRS--SRRSYSSSSDASSDQSCYSRQRSYS 890
                S     +   +  SRSRSR  R+    R   S  S+    +A   +    R RS  
Sbjct: 615  ERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSID 674

Query: 891  DDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDD----------DYSLSCS 940
             D      +R R   KR            K   K  K+SS DD           +S S S
Sbjct: 675  KDRKKKDKEREREQDKRKE--------KQKREEKDFKFSSQDDRLKRKRESERTFSRSGS 726

Query: 941  --------QSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDR 992
                     SR  S+  T + S+    S SS  S S S   S+   A   + SRS S ++
Sbjct: 727  ISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEK 786

Query: 993  S-RSTRSPSQRSGSRKRS 1009
            S RS +  S++  S+ RS
Sbjct: 787  SQRSGKKASRKHKSKSRS 804



 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 69/321 (21%), Positives = 124/321 (38%), Gaps = 16/321 (4%)

Query: 676 KKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEP 735
           K+ K+ +K  + +    +     S+   S   S          + SS  +     PK + 
Sbjct: 497 KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKK 556

Query: 736 PGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSC 795
             S S +P  + RR++  S  R +  E   +  K      S+       + +   P    
Sbjct: 557 RHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRER 616

Query: 796 QRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSR 855
           +R     R  R++  S+  S D    D     L   S  ++  E +E++   E SRS  +
Sbjct: 617 RRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNS-HKHKGEAKEQERKKERSRSIDK 675

Query: 856 SGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSD 915
             ++    R          +   D+    ++R   D  +S   DR +R  +       S 
Sbjct: 676 DRKKKDKER----------EREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSG 725

Query: 916 YASSK---HRSKR-HKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSK 971
             S K   H S++  K S++ D    S S S  RS S +   S+ + +++    SRSRS 
Sbjct: 726 SISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEK-KAKKPKHSRSRSV 784

Query: 972 RRSRSTTAHSWQRSRSYSRDR 992
            +S+ +   + ++ +S SR R
Sbjct: 785 EKSQRSGKKASRKHKSKSRSR 805



 Score = 44.7 bits (104), Expect = 7e-04
 Identities = 45/192 (23%), Positives = 73/192 (38%), Gaps = 15/192 (7%)

Query: 664 SKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSA 723
           ++  RS    R K   +    S +  KHK + +E+  K E      K +K+K K+ +   
Sbjct: 629 NRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQ 688

Query: 724 PADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGG 783
               E+  + E     S         +QDD  +R   +E   S     G        H  
Sbjct: 689 DKRKEKQKREEKDFKFS---------SQDDRLKRKRESERTFS---RSGSISVKIIRHDS 736

Query: 784 RKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEE 843
           R+   +      ++ +G+  S RSS  S  SS ++ +      R      SQ S ++   
Sbjct: 737 RQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKA-- 794

Query: 844 DSGSEHSRSRSR 855
            S    S+SRSR
Sbjct: 795 -SRKHKSKSRSR 805



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 86/402 (21%), Positives = 140/402 (34%), Gaps = 109/402 (27%)

Query: 732  KPEPPGSGSPAPPRRRRRAQ----------------------DDSQRRSLPA------EE 763
            +P PPG   PAPP+ RR                         D  +RR+LPA      E+
Sbjct: 185  QPGPPGP--PAPPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEK 242

Query: 764  GSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDA 823
                K+ +       Q       K +      +   G +   RS   S     D ++ +A
Sbjct: 243  MEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEA 302

Query: 824  SSHRLHQKSPSQYSEEEEEEDSGSEHS--------------------------------- 850
            +S     +SPS   +EE  +   +E                                   
Sbjct: 303  ASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAH 362

Query: 851  RSRSRSGRRHSSHRSSRRSYS--------SSSDASSDQSCYSRQRSYSDDSYSDYSDRSR 902
            R  +++  +  +  S+  S +         S D+  ++S    + S +DD    +  R +
Sbjct: 363  RKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQK 422

Query: 903  -----RHSKRSHDSDDSDYASSKHRSKRHKYSSSD----DDYSLSCSQSRSRSRSHTRER 953
                 R  K      D      K +++R     ++    +  SLS  ++R        E+
Sbjct: 423  QEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEK 482

Query: 954  SRS-------------------RGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSR 994
             R+                   +GRSRS S S   S   SR+++  S   S SYS   S 
Sbjct: 483  KRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYS-SSSG 541

Query: 995  STRSPSQRSGSRKRSWGHESPEERHS-GRRDFIRSKIYRSQS 1035
            S+R+ S RS S KR       ++RHS  R   I+++  RS+S
Sbjct: 542  SSRT-SSRSSSPKR-------KKRHSRSRSPTIKARRSRSRS 575


>gi|133922600 splicing factor, arginine/serine-rich 16 [Homo
           sapiens]
          Length = 674

 Score = 87.8 bits (216), Expect = 7e-17
 Identities = 100/318 (31%), Positives = 133/318 (41%), Gaps = 31/318 (9%)

Query: 676 KKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKK----NKSSAPADSERGP 731
           +K K+  ++ KH    KA  EEK+    SG +S+++++  R+K     K S P+ + R  
Sbjct: 240 RKDKEEAEAIKHA---KALEEEKA--MYSGRRSRRQRREFREKRLRGRKISPPSYARRDS 294

Query: 732 KPEPPGSGSP----APPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGG-RKH 786
               P   SP    +  R R R+    +   +       G  +E    +++    G    
Sbjct: 295 PTYDPYKRSPSESSSESRSRSRSPTPGREEKITFITSFGGSDEEAAAAAAAAAASGVTTG 354

Query: 787 KGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSG 846
           K   PP       G   S+R   RS  SS    +   SS R   +S S+         SG
Sbjct: 355 KPPAPPQPGGPAPGRNASAR--RRSSSSSSSSSASRTSSSRSSSRSSSRSRRGGGYYRSG 412

Query: 847 SEHSRSRSRSGRRHSSH-----RSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRS 901
             H+RSRSRS  R  S      RS  R    S   S D   YSR    S      Y  R 
Sbjct: 413 -RHARSRSRSWSRSRSRSRRYSRSRSRGRRHSGGGSRDGHRYSR----SPARRGGYGPR- 466

Query: 902 RRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRS--RSRSHTRERSRSRGR 959
           RR   RSH  D   Y       + H  S S   +SLS S+SRS  RSRSH+   S+SR R
Sbjct: 467 RRSRSRSHSGD--RYRRGGRGLRHHSSSRSRSSWSLSPSRSRSLTRSRSHSPSPSQSRSR 524

Query: 960 SRSSSCSRSRSKRRSRST 977
           SRS S S S S  R + T
Sbjct: 525 SRSRSQSPSPSPAREKLT 542



 Score = 74.3 bits (181), Expect = 8e-13
 Identities = 94/396 (23%), Positives = 145/396 (36%), Gaps = 43/396 (10%)

Query: 661  SLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNK 720
            S PS   R   ++   K+   + SS+ + + ++ T  +  K           +       
Sbjct: 285  SPPSYARRDSPTYDPYKRSPSESSSESRSRSRSPTPGREEKITFITSFGGSDEEAAAAAA 344

Query: 721  SSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQD 780
            ++A +    G  P PP  G PAP R     +  S   S  +   +S  +      S S+ 
Sbjct: 345  AAAASGVTTGKPPAPPQPGGPAPGRNASARRRSSSSSSSSSASRTSSSRSSSRSSSRSRR 404

Query: 781  HGG----RKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQY 836
             GG     +H      S  + R+ ++R SRS  R +  SG    D    HR + +SP++ 
Sbjct: 405  GGGYYRSGRHARSRSRSWSRSRSRSRRYSRSRSRGRRHSGGGSRD---GHR-YSRSPARR 460

Query: 837  SEEEEEEDSGS-EHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYS-DDSY 894
                    S S  HS  R R G R   H SS RS SS S + S     +R RS+S   S 
Sbjct: 461  GGYGPRRRSRSRSHSGDRYRRGGRGLRHHSSSRSRSSWSLSPSRSRSLTRSRSHSPSPSQ 520

Query: 895  SDYSDRSRRHS-----------------------KRSHDSDDSDYASSK------HRSKR 925
            S    RSR  S                       K++  +   +  ++K       + K 
Sbjct: 521  SRSRSRSRSQSPSPSPAREKLTRPAASPAVGEKLKKTEPAAGKETGAAKPKLTPQEKLKL 580

Query: 926  HKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRS 985
                + +  +      ++ +      ER       R+ +      +R  R      W+  
Sbjct: 581  RMQKALNRQFKADKKAAQEKMIQQEHERQEREDELRAMARKIRMKERERREKEREEWE-- 638

Query: 986  RSYSR-DRSRSTRSPSQRSGSRKRSWGH-ESPEERH 1019
            R YSR  RS S R   + S SR+RS     SP  RH
Sbjct: 639  RQYSRQSRSPSPRYSREYSSSRRRSRSRSRSPHYRH 674



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 109/410 (26%), Positives = 156/410 (38%), Gaps = 91/410 (22%)

Query: 796  QRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSR 855
            QRR   ++  R    S PS    DS    ++  +++SPS+ S E          SRSRSR
Sbjct: 270  QRREFREKRLRGRKISPPSYARRDSP---TYDPYKRSPSESSSE----------SRSRSR 316

Query: 856  SGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDY---------------SDR 900
            S    +  R  + ++ +S   S +++  +   + +    +                 +  
Sbjct: 317  SP---TPGREEKITFITSFGGSDEEAAAAAAAAAASGVTTGKPPAPPQPGGPAPGRNASA 373

Query: 901  SRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRS 960
             RR S  S  S  S  +SS+  S+    S     Y  S   +RSRSRS +R RSRSR  S
Sbjct: 374  RRRSSSSSSSSSASRTSSSRSSSRSSSRSRRGGGYYRSGRHARSRSRSWSRSRSRSRRYS 433

Query: 961  RSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSG----SRKRSWGHESPE 1016
            R    SRSR +R S              SRD  R +RSP++R G     R RS  H    
Sbjct: 434  R----SRSRGRRHSGGG-----------SRDGHRYSRSPARRGGYGPRRRSRSRSHSGDR 478

Query: 1017 ERHSGR----RDFIRSKIYRSQSPHYFRS---GRGEGPGKKDDGRGDDSKATGPPSQNSN 1069
             R  GR        RS+   S SP   RS    R   P                PSQ+ +
Sbjct: 479  YRRGGRGLRHHSSSRSRSSWSLSPSRSRSLTRSRSHSPS---------------PSQSRS 523

Query: 1070 IGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPNKAGPKLKDPPQG 1129
                R      SP            EK+   +    P+V E+++ T   AG +      G
Sbjct: 524  RSRSRSQSPSPSP----------AREKL--TRPAASPAVGEKLKKTEPAAGKE-----TG 566

Query: 1130 YFGPKLPPSLGNKPVLPLIGKLPATRKPNKKCEESGLERGEEQEQSETEE 1179
               PKL P    K  L +   L    K +KK  +  + + E + Q   +E
Sbjct: 567  AAKPKLTPQ--EKLKLRMQKALNRQFKADKKAAQEKMIQQEHERQEREDE 614



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 85/389 (21%), Positives = 133/389 (34%), Gaps = 69/389 (17%)

Query: 605 GLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPS 664
           G+  G+P    + GG    R++  R  + +S S+ S         S  S +  + RS  S
Sbjct: 350 GVTTGKPPAPPQPGGPAPGRNASARRRSSSSSSSSS--------ASRTSSSRSSSRS-SS 400

Query: 665 KKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAP 724
           +  R G  +R         S +H R          S++ S  +S+ R +R  +       
Sbjct: 401 RSRRGGGYYR---------SGRHAR----------SRSRSWSRSRSRSRRYSRSR----- 436

Query: 725 ADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGR 784
               RG +    GS            +D  +    PA  G  G +      S S+ H G 
Sbjct: 437 ---SRGRRHSGGGS------------RDGHRYSRSPARRGGYGPRRR----SRSRSHSGD 477

Query: 785 KHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEED 844
           +++        +   G +  S S  RS  S     S   +  R H  SPSQ         
Sbjct: 478 RYR--------RGGRGLRHHSSSRSRSSWSLSPSRSRSLTRSRSHSPSPSQSRSRSRSRS 529

Query: 845 SGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRH 904
                S +R +  R  +S     +   +   A  +      + +  +           R 
Sbjct: 530 QSPSPSPAREKLTRPAASPAVGEKLKKTEPAAGKETGAAKPKLTPQEKLKLRMQKALNRQ 589

Query: 905 SKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSS 964
            K      D   A  K   + H+    +D+      + R + R   RE+ R     + S 
Sbjct: 590 FKA-----DKKAAQEKMIQQEHERQEREDELRAMARKIRMKERER-REKEREEWERQYSR 643

Query: 965 CSRSRSKRRSRSTTAHSWQRSRSYSRDRS 993
            SRS S R SR    +S  R RS SR RS
Sbjct: 644 QSRSPSPRYSRE---YSSSRRRSRSRSRS 669


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
            [Homo sapiens]
          Length = 1481

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 171/702 (24%), Positives = 253/702 (36%), Gaps = 64/702 (9%)

Query: 643  NKQEPGGSHGSETEDTGRSLPSKKERSGKSH-RHKKKKKHKKSSKHKRKHKADTEEKSSK 701
            N +  GG        +G   PS    S  S  RH+   KHK+   HK KH  D    + +
Sbjct: 3    NSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKR---HKSKHSKDMGLVTPE 59

Query: 702  AES-GEKSKKRKKRKRKKNKSSAPADS-----ERGPKPEPPGSGSPAPPRRRRRAQDDSQ 755
            A S G   K   +     + S   +D      +R    E  GS       + R  Q    
Sbjct: 60   AASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRS 119

Query: 756  RRSLPAEEGSSGKKDEGGGGSSSQDH---GGRKHKGELPPS--SCQRRAGTKRSSRSSHR 810
            R  L A++    K  E    S S      G  K   E        Q    + + SRSS  
Sbjct: 120  RDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKL 179

Query: 811  SQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSY 870
             +  +  E  +  S H+   +S S    E  +     +  + RSRS  R  S  S +   
Sbjct: 180  HKEKTRKE-RELKSGHK--DRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDS 236

Query: 871  SSSSDASSDQSCYSRQRSYSDDSYSDYS----DRSRRHSKRSHDSDDSDYASS-KHRSKR 925
             S +    D    S  RS++  +Y  Y       SRR S      + S Y SS +  S  
Sbjct: 237  PSGASYGQDYDL-SPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPY 295

Query: 926  HKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRS-RSKRRSRSTTAHSWQ- 983
             +   S   YS   S S  RS S++       GR RSSS   S RS  RS   +  S + 
Sbjct: 296  SRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKS 355

Query: 984  RSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGR 1043
            RSRS +  R  S+ S  +RS SR R   H S           + +++ R +      +  
Sbjct: 356  RSRSPAYSRHSSSHSKKKRSSSRSR---HSSISPVRLPLNSSLGAELSRKKKERAAAAAA 412

Query: 1044 GEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVE 1103
             +  GK+  G    S    P  +NS++        D   E K    +  L +     ++ 
Sbjct: 413  AKMDGKESKG----SPVFLPRKENSSV-----EAKDSGLESKKLPRSVKLEKSAPDTELV 463

Query: 1104 RKPSVSEEVQATPNKAGPKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNKKCEE 1163
                ++ EV+ + +    KL +  + +    L              K   TR       +
Sbjct: 464  NVTHLNTEVKNSSDTGKVKLDENSEKHLVKDL--------------KAQGTRDSKPIALK 509

Query: 1164 SGLERGEEQEQSETEEGPPGSSDALFGHQFPSEETTGPLLDPPPEESKSGEATADHPVAP 1223
              +   +E E SE E  PP  + A      P+  TT P   PP        A    P  P
Sbjct: 510  EEIVTPKETETSEKETPPPLPTIASPPPPLPT--TTPPPQTPPLPPLPPIPALPQQPPLP 567

Query: 1224 LGTPAHSDCYPGDPTISHNYLPDPSDGDT-LESLDSSSQPGPVESSL---LPIAPDLEHF 1279
               PA S      P  S + LP  +   T   S  ++SQP PV+ S+   + +   + H 
Sbjct: 568  PSQPAFSQV----PASSTSTLPPSTHSKTSAVSSQANSQP-PVQVSVKTQVSVTAAIPHL 622

Query: 1280 -PSYAPPSGDPSIESTDGAEDASLAPLESQPITFTPEEMEKY 1320
              S  PP   P +   D   D+    L S+P+    E+  ++
Sbjct: 623  KTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRH 664



 Score = 36.2 bits (82), Expect = 0.25
 Identities = 89/457 (19%), Positives = 157/457 (34%), Gaps = 59/457 (12%)

Query: 347 GDSDGSSNLDGKKEDEDPQDGGSLAST------LSKLKR--MKREEGAGATEPEY----- 393
           G  DGS    G  +   P  GG  +++      +SK KR   K  +  G   PE      
Sbjct: 9   GKKDGSGGASGTLQ---PSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGT 65

Query: 394 -------YHYIPPAHCKVKPNFPFLLFMRASEQMDGDNTT----------HPKNAPESKK 436
                  Y  I         +  F L  R +++  G + +          H ++    K 
Sbjct: 66  VIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKA 125

Query: 437 GSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSEPGSKAEAKKALGGDVSDQSLE 496
             + K KS   ++ S   +  +S  S++  E       E     +A+ A       +S +
Sbjct: 126 KQTEKEKSQEVSSKSGSMKDRISGSSKRSNE-------ETDDYGKAQVAKSSSKESRSSK 178

Query: 497 SHSQKVSETQMCESN----SSKETSLATPAGKESQEGPKHPTGPFFPVLSKDESTALQWP 552
            H +K  + +  +S     S       TP   ++ + PK  +       S D S     P
Sbjct: 179 LHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWS-DSSKQDDSP 237

Query: 553 SELLIFTKAEPSISYSCNPLYFD-FKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEP 611
           S        + S S S     +D +K S    +R +    P    S+ +   +   P   
Sbjct: 238 SGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYS- 296

Query: 612 NKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGK 671
            + + V      RSS        SG + S   ++       S+   +   LPS+K    +
Sbjct: 297 RRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSR 356

Query: 672 SH-----RHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPAD 726
           S      RH      KK S  + +H + +  +     S      RKK++R    ++A  D
Sbjct: 357 SRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMD 416

Query: 727 SERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEE 763
            +          GSP    R+  +  +++   L +++
Sbjct: 417 GKE-------SKGSPVFLPRKENSSVEAKDSGLESKK 446


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
            [Homo sapiens]
          Length = 1490

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 171/702 (24%), Positives = 253/702 (36%), Gaps = 64/702 (9%)

Query: 643  NKQEPGGSHGSETEDTGRSLPSKKERSGKSH-RHKKKKKHKKSSKHKRKHKADTEEKSSK 701
            N +  GG        +G   PS    S  S  RH+   KHK+   HK KH  D    + +
Sbjct: 3    NSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKR---HKSKHSKDMGLVTPE 59

Query: 702  AES-GEKSKKRKKRKRKKNKSSAPADS-----ERGPKPEPPGSGSPAPPRRRRRAQDDSQ 755
            A S G   K   +     + S   +D      +R    E  GS       + R  Q    
Sbjct: 60   AASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRS 119

Query: 756  RRSLPAEEGSSGKKDEGGGGSSSQDH---GGRKHKGELPPS--SCQRRAGTKRSSRSSHR 810
            R  L A++    K  E    S S      G  K   E        Q    + + SRSS  
Sbjct: 120  RDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKL 179

Query: 811  SQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSY 870
             +  +  E  +  S H+   +S S    E  +     +  + RSRS  R  S  S +   
Sbjct: 180  HKEKTRKE-RELKSGHK--DRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDS 236

Query: 871  SSSSDASSDQSCYSRQRSYSDDSYSDYS----DRSRRHSKRSHDSDDSDYASS-KHRSKR 925
             S +    D    S  RS++  +Y  Y       SRR S      + S Y SS +  S  
Sbjct: 237  PSGASYGQDYDL-SPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPY 295

Query: 926  HKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRS-RSKRRSRSTTAHSWQ- 983
             +   S   YS   S S  RS S++       GR RSSS   S RS  RS   +  S + 
Sbjct: 296  SRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKS 355

Query: 984  RSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGR 1043
            RSRS +  R  S+ S  +RS SR R   H S           + +++ R +      +  
Sbjct: 356  RSRSPAYSRHSSSHSKKKRSSSRSR---HSSISPVRLPLNSSLGAELSRKKKERAAAAAA 412

Query: 1044 GEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVE 1103
             +  GK+  G    S    P  +NS++        D   E K    +  L +     ++ 
Sbjct: 413  AKMDGKESKG----SPVFLPRKENSSV-----EAKDSGLESKKLPRSVKLEKSAPDTELV 463

Query: 1104 RKPSVSEEVQATPNKAGPKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNKKCEE 1163
                ++ EV+ + +    KL +  + +    L              K   TR       +
Sbjct: 464  NVTHLNTEVKNSSDTGKVKLDENSEKHLVKDL--------------KAQGTRDSKPIALK 509

Query: 1164 SGLERGEEQEQSETEEGPPGSSDALFGHQFPSEETTGPLLDPPPEESKSGEATADHPVAP 1223
              +   +E E SE E  PP  + A      P+  TT P   PP        A    P  P
Sbjct: 510  EEIVTPKETETSEKETPPPLPTIASPPPPLPT--TTPPPQTPPLPPLPPIPALPQQPPLP 567

Query: 1224 LGTPAHSDCYPGDPTISHNYLPDPSDGDT-LESLDSSSQPGPVESSL---LPIAPDLEHF 1279
               PA S      P  S + LP  +   T   S  ++SQP PV+ S+   + +   + H 
Sbjct: 568  PSQPAFSQV----PASSTSTLPPSTHSKTSAVSSQANSQP-PVQVSVKTQVSVTAAIPHL 622

Query: 1280 -PSYAPPSGDPSIESTDGAEDASLAPLESQPITFTPEEMEKY 1320
              S  PP   P +   D   D+    L S+P+    E+  ++
Sbjct: 623  KTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRH 664



 Score = 36.2 bits (82), Expect = 0.25
 Identities = 89/457 (19%), Positives = 157/457 (34%), Gaps = 59/457 (12%)

Query: 347 GDSDGSSNLDGKKEDEDPQDGGSLAST------LSKLKR--MKREEGAGATEPEY----- 393
           G  DGS    G  +   P  GG  +++      +SK KR   K  +  G   PE      
Sbjct: 9   GKKDGSGGASGTLQ---PSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGT 65

Query: 394 -------YHYIPPAHCKVKPNFPFLLFMRASEQMDGDNTT----------HPKNAPESKK 436
                  Y  I         +  F L  R +++  G + +          H ++    K 
Sbjct: 66  VIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKA 125

Query: 437 GSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSEPGSKAEAKKALGGDVSDQSLE 496
             + K KS   ++ S   +  +S  S++  E       E     +A+ A       +S +
Sbjct: 126 KQTEKEKSQEVSSKSGSMKDRISGSSKRSNE-------ETDDYGKAQVAKSSSKESRSSK 178

Query: 497 SHSQKVSETQMCESN----SSKETSLATPAGKESQEGPKHPTGPFFPVLSKDESTALQWP 552
            H +K  + +  +S     S       TP   ++ + PK  +       S D S     P
Sbjct: 179 LHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWS-DSSKQDDSP 237

Query: 553 SELLIFTKAEPSISYSCNPLYFD-FKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEP 611
           S        + S S S     +D +K S    +R +    P    S+ +   +   P   
Sbjct: 238 SGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYS- 296

Query: 612 NKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGK 671
            + + V      RSS        SG + S   ++       S+   +   LPS+K    +
Sbjct: 297 RRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSR 356

Query: 672 SH-----RHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPAD 726
           S      RH      KK S  + +H + +  +     S      RKK++R    ++A  D
Sbjct: 357 SRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMD 416

Query: 727 SERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEE 763
            +          GSP    R+  +  +++   L +++
Sbjct: 417 GKE-------SKGSPVFLPRKENSSVEAKDSGLESKK 446


>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
          Length = 1312

 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 132/607 (21%), Positives = 219/607 (36%), Gaps = 89/607 (14%)

Query: 676  KKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKN-KSSAPADSERGPKPE 734
            ++K   ++  +++++  +     +  A +G  ++K+ +R+RK++ ++   A S  G +P 
Sbjct: 483  RRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPA 542

Query: 735  PPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSS 794
            PP   SP   ++ R       R   P    SS  +      S S+    R        S+
Sbjct: 543  PPAPASPWDSKKHR------SRDRKPGSHASSSARRRSRSRSRSRSTRRRSR------ST 590

Query: 795  CQRRAGTKRS-SRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSR 853
             +RR G++RS SR   R +  S       +SS      S  +    +  +  GS+  + R
Sbjct: 591  DRRRGGSRRSRSREKRRRRRRSASPPPATSSS----SSSRRERHRGKHRDGGGSKKKKKR 646

Query: 854  SRSGRRHSSHRSSRRSYSSSSDASSDQSCY---SRQRSYSDDSYSDYSDRSRRHSKRSHD 910
            SRS     S   S ++ + +   S   SC    SR+R     S  D +D      KR+  
Sbjct: 647  SRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTIT 706

Query: 911  SDDSDYASSKHRSKRHKYSSSD----DDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCS 966
                D +  +  S     S       D   LS  +   +S    R RS   G + SSS S
Sbjct: 707  VGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRS---GAASSSSSS 763

Query: 967  RSRSKRRSRSTTAHSWQRSRSYSRDRSRST---RSPSQRSGSR--------KRSWGHESP 1015
            R +  RR ++       R R   RDR RS+   R P + + S             G  S 
Sbjct: 764  REKGSRR-KALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSS 822

Query: 1016 EERHSGRRDFIRSKI-------YRSQSPHYFRSGRGEGPGKKDDGRGDDSKATG-PPSQN 1067
                S R+  ++SK+         S +P    +  G G       R  +S++    P + 
Sbjct: 823  SSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDER 882

Query: 1068 SNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVS------------------ 1109
            +     + + G   P+ K  V AK   +K +  K + KPS +                  
Sbjct: 883  APTEMAKAAPGSTKPK-KTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVS 941

Query: 1110 ------------------EEVQATPNKAGPKLKDPPQGYFGPKLPPSLGNKPVLPLIGKL 1151
                              EE   +  +   K+   P     P  P    +   +    K 
Sbjct: 942  LKKSKADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKT 1001

Query: 1152 PATR-KPNKKCEESGLERGEEQEQSETEEGPPGSSDALFGHQFPSEETTGPLLDPPPEES 1210
            P     P +  EE+G+  G E+E+ E EE      +     Q P+  T        P  +
Sbjct: 1002 PEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEE---EQQPATTTATSTAAAAPSTA 1058

Query: 1211 KSGEATA 1217
             S  +TA
Sbjct: 1059 PSAGSTA 1065



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 102/469 (21%), Positives = 177/469 (37%), Gaps = 50/469 (10%)

Query: 579  SRNKDART-KGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGS 637
            +R K  R  K + + K+  SSS     G  P  P  +     +K  RS   +  + AS S
Sbjct: 515  TRKKSRRERKRSGEAKEAASSSS----GTQPAPPAPASPWDSKKH-RSRDRKPGSHASSS 569

Query: 638  ACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEE 697
            A      +       S +  T R   S   R G S R + ++K ++  +      A +  
Sbjct: 570  ARRRSRSR-------SRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSS 622

Query: 698  KSSKAE-------SGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRR--RR 748
             SS+ E        G  SKK+KKR R + +  +   SE+ P P PP SGS +   R  RR
Sbjct: 623  SSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRR 682

Query: 749  RAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRR--------AG 800
            R       + L   +  + K+    G     D  G       P SS +R         +G
Sbjct: 683  RGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRG---PSPAPASSPKREVLYDSEGLSG 739

Query: 801  TKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRH 860
             +R  +SS + +  SG   S  +S  +  ++      + + + D   +  RS  ++    
Sbjct: 740  EERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPK 799

Query: 861  SSHRSS----RRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDY 916
             S  SS    +   SS S +SS  S  S ++       +         +  + D+  +  
Sbjct: 800  ESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGL 859

Query: 917  AS-----SKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRER-------SRSRGRSRSSS 964
             S     S+ R  R  +   D+      +++   S    + +        +++G    + 
Sbjct: 860  GSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTK 919

Query: 965  CSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHE 1013
             S++R K RS   +  S  +  S  + ++ S    +   G+ + SW  E
Sbjct: 920  PSKTRKKVRSGGGSGGSGGQV-SLKKSKADSCSQAAGTKGAEETSWSGE 967



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 66/348 (18%), Positives = 123/348 (35%), Gaps = 57/348 (16%)

Query: 579  SRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSA 638
            S  KD R  G               + LD G+ ++ ++   ++   S   R   P   SA
Sbjct: 746  SSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKAR---PPKESA 802

Query: 639  CSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEK 698
             S     +P  S GS +  +  S  S+K            K   K +   R+  + T   
Sbjct: 803  PSSGPPPKPPVSSGSGSSSSSSSCSSRKV-----------KLQSKVAVLIREGVSSTTPA 851

Query: 699  SSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKP---EPPGSGSPAPPRRRRRAQDDSQ 755
               A +G  S   K  + ++++S      ER P       PGS  P   + + +A     
Sbjct: 852  KDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKT 911

Query: 756  RRSLPAEEGS-SGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPS 814
            + +    + S + KK   GGGS     GG+    +    SC + AGTK +  +S   +  
Sbjct: 912  KGTKGKTKPSKTRKKVRSGGGSGGS--GGQVSLKKSKADSCSQAAGTKGAEETSWSGEER 969

Query: 815  SG-------------------------------------DEDSDDASSHRLHQKSPSQYS 837
            +                                      +E +++A      ++   +  
Sbjct: 970  AAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEE 1029

Query: 838  EEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSR 885
            EEEEEE+   +   + + +    ++  ++  + S++ D+ ++    SR
Sbjct: 1030 EEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASR 1077



 Score = 35.0 bits (79), Expect = 0.55
 Identities = 62/233 (26%), Positives = 95/233 (40%), Gaps = 32/233 (13%)

Query: 301  SFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKPDEKSSDQGLQKVG---DSDGSSNLDG 357
            S S      VKL+S  +V      EG S   T P + ++  GL  +G     D  S    
Sbjct: 822  SSSSCSSRKVKLQSKVAVL---IREGVSS--TTPAKDAASAGLGSIGVKFSRDRESRSPF 876

Query: 358  KKEDED-PQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPPAHCKVKPNFPFLLFMRA 416
             K DE  P +    A   +K K+ K +  AGA + +          K KP+       + 
Sbjct: 877  LKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTK------GTKGKTKPS-------KT 923

Query: 417  SEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSEP 476
             +++     +       S K S  K  SC +AA ++GAE+T    S   +E +   PS P
Sbjct: 924  RKKVRSGGGSGGSGGQVSLKKS--KADSCSQAAGTKGAEET----SWSGEERAAKVPSTP 977

Query: 477  GSK-AEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQE 528
              K A    AL  D   Q+++S S K  E       +++E  +   A +E +E
Sbjct: 978  PPKAAPPPPALTPD--SQTVDS-SCKTPEVSFLPEEATEEAGVRGGAEEEEEE 1027



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 36/133 (27%), Positives = 49/133 (36%), Gaps = 34/133 (25%)

Query: 721 SSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQD 780
           S +P+ S   P P PP    PAPP  R    D       P +E  S         +  Q 
Sbjct: 198 SPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFH----PTDEAYSPPP------APEQK 247

Query: 781 HGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEE 840
           +   +  G  P SS    AGT           PS  +E+ ++            +  EE+
Sbjct: 248 YDPFEPTGSNPSSS----AGT-----------PSPEEEEEEE---------EEEEEEEED 283

Query: 841 EEEDSGSEHSRSR 853
           EEE+ G   S SR
Sbjct: 284 EEEEEGLSQSISR 296


>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
          Length = 1163

 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 137/623 (21%), Positives = 225/623 (36%), Gaps = 92/623 (14%)

Query: 402 CKVKPN-FPFLLFMRASEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSE 460
           CK +P+ FPF        Q     T   K    SK  +  + KS +K       + + SE
Sbjct: 338 CKTEPSKFPF---PTKESQQSNFGTGEQKRYNPSKTSNGHQSKSMLK----DDLKLSSSE 390

Query: 461 VSEQPKETSMTEP-SEPGSKAEAK--KALGGDVSDQSLESHSQKVSETQMCESNSSKETS 517
            S+  ++   T P S PGS +E     + G D S     SHS   SE+     + S+ +S
Sbjct: 391 DSDGEQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSG--SESSSGSDSESESSS 448

Query: 518 LATPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCN-PLYFDF 576
             + A + SQ     P  P       D      W +++    K  P+ S   N P    +
Sbjct: 449 SDSEANEPSQSASPEPEPPPTNKWQLDN-----WLNKVNPH-KVSPASSVDSNIPSSQGY 502

Query: 577 KLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASG 636
           K    K+ R +GT       S  K+      PG  +K+ + G E    S  GR  +PA  
Sbjct: 503 K----KEGREQGTGNSYTDTSGPKE-TSSATPGRDSKTIQKGSE----SGRGRQKSPAQS 553

Query: 637 SACSG---LNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKA 693
            + +    + K++P  +  +  E+    L  + E            +HK ++K  RK   
Sbjct: 554 DSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNI 613

Query: 694 DTEEKSSKAESGEKSK-KRKKRKRKKNKSSAPADSERGPKPE----PPGSGSPAPPRRRR 748
             E KSS   + EK K K   +  +K++     D+      E    PP S +P  P   R
Sbjct: 614 KKESKSSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPKYPESNR 673

Query: 749 R-------AQDDS---QRRSLPAEE-----------------------------GSSGKK 769
                    ++DS   QR   P EE                             G   K+
Sbjct: 674 TPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKPYKE 733

Query: 770 DEGGGGS-----SSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDAS 824
            E   G             +K   E   +  +R+   +  +R+S   +P + D++S    
Sbjct: 734 TEPPKGEKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKPKTEDKNSAGHK 793

Query: 825 SHRLHQKSPSQYSEEEE----------EEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSS 874
                + S    ++E++           +D  +EH  SR R+  + SS +SS  S   +S
Sbjct: 794 PSSNRESSKQSAAKEKDLLPSPAGPVPSKDPKTEHG-SRKRTISQSSSLKSSSNSNKETS 852

Query: 875 DASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDD 934
            +S + S  S+Q+     + S   +   +    S +   S       + +R K    D +
Sbjct: 853 GSSKNSSSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTLDSSKPRRTKLVFDDRN 912

Query: 935 YSLSCSQSRSRSRSHTRERSRSR 957
           YS       ++   H  +    R
Sbjct: 913 YSADHYLQEAKKLKHNADALSDR 935



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 133/614 (21%), Positives = 210/614 (34%), Gaps = 72/614 (11%)

Query: 663  PSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSS 722
            PS  E+S  +   ++     +SSK      A +  +S K  SG +S    +R    + S 
Sbjct: 84   PSADEKSNPNFFEQRHGGSHQSSKWTPVGPAPSTSQSQKRSSGLQSGHSSQRTSAGSSSG 143

Query: 723  APADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHG 782
              +  +R  +     SGS +  + +  ++    R S P +  +    +     S   DH 
Sbjct: 144  TNSSGQRHDRESYNNSGSSSRKKGQHGSEHSKSRSSSPGKPQAVSSLNSSHSRSHGNDHH 203

Query: 783  GRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQY-----S 837
             ++H+    P        +      S     +     S  + S+ + QK P+ Y      
Sbjct: 204  SKEHQRSKSPRDPDANWDSPSRVPFSSGQHSTQSFPPSLMSKSNSMLQK-PTAYVRPMDG 262

Query: 838  EEEEEEDSGSEHSRSRSRSGRRHSSHRSSRR--------SYSSSSDASSDQSCYSRQRSY 889
            +E  E    SEH  S+S          SS+         S    + AS D SC       
Sbjct: 263  QESMEPKLSSEHYSSQSHGNSMTELKPSSKAHLTKLKIPSQPLDASASGDVSCVDEILKE 322

Query: 890  SDDSY------------------------SDYSDRSRRHSKRSHDSDDSDYASSKHRSKR 925
               S+                        S  S+      KR + S  S+   SK   K 
Sbjct: 323  MTHSWPPPLTAIHTPCKTEPSKFPFPTKESQQSNFGTGEQKRYNPSKTSNGHQSKSMLKD 382

Query: 926  H-KYSSSDD-DYSLSCSQSRSRSR-------SHTRERSRSRGRSRSSSCSRSRSKRRSRS 976
              K SSS+D D    C ++  RS        SH         R  SSS S S S   S S
Sbjct: 383  DLKLSSSEDSDGEQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDS 442

Query: 977  TTAHSWQRSRSYSRDRSRSTR-SPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQS 1035
             +  S   S +    +S S    P   +  +  +W ++    + S     + S I  SQ 
Sbjct: 443  ESESSSSDSEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASS-VDSNIPSSQG 501

Query: 1036 PHYFRSGRGEGPGKK---DDGRGDDSKAT-GPPSQNSNIGTGRGSEGDCSPEDKNSVTAK 1091
              Y + GR +G G       G  + S AT G  S+    G+  G     SP   +S T +
Sbjct: 502  --YKKEGREQGTGNSYTDTSGPKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQR 559

Query: 1092 LLLEKIQSRKVERKPSVSEEVQATPNKAGPKLKDPPQGYFGPKLPPSLGNKPVLPLIGKL 1151
              + K       ++P  +E+  A   + G K++          +P S             
Sbjct: 560  RTVGK-------KQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHK-------AAT 605

Query: 1152 PATRKPNKKCEESGLER--GEEQEQSETEEGPPGSSDALFGHQFPSEETTGPLLDPPPEE 1209
              +RKPN K E     R   E+++   T +    S + +      S+      L P  + 
Sbjct: 606  KGSRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQT 665

Query: 1210 SKSGEATADHPVAP 1223
             K  E+    PV P
Sbjct: 666  PKYPESNRT-PVKP 678



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 115/539 (21%), Positives = 200/539 (37%), Gaps = 54/539 (10%)

Query: 224 DEEGGEDDKDESATNSGTGATASCGLGSEFSTDKGGPFTAVQITNTTGLAQAPGLASQGI 283
           + EG ++ +D+S+++SG+ +++     SE S+            N    + +P       
Sbjct: 417 NSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSE-------ANEPSQSASPEPEPPPT 469

Query: 284 SFGIKNNLGTPLQKLGV-SFSFAKKAPVKLESIASVFKDHAEEGTSE---DGTKPDEKSS 339
           +   K  L   L K+     S A      + S     K+  E+GT     D + P E SS
Sbjct: 470 N---KWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGREQGTGNSYTDTSGPKETSS 526

Query: 340 -DQGLQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIP 398
              G        GS +  G+++     D  +   T+ K K+ K+ E A A EP       
Sbjct: 527 ATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGK-KQPKKAEKAAAEEPR------ 579

Query: 399 PAHCKVKPNFPFLLF--MRASEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEK 456
               K++   P  L   M +S        +   N  +  K SSP+P       A +   K
Sbjct: 580 -GGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKESK-SSPRP------TAEKKKYK 631

Query: 457 TVSEVSEQPKETSMTEPSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKET 516
           + S+ S++ +E   T+ S   S  E++       + +  ES+   V  + + E +S    
Sbjct: 632 STSKSSQKSREIIETDTSSSDSD-ESESLPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQ 690

Query: 517 SLATPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDF 576
            + +P  ++    P       +P++ K          +L + T+          P   + 
Sbjct: 691 RMFSPMEEKELLSPLSEPDDRYPLIVK---------IDLNLLTRIPGKPYKETEPPKGEK 741

Query: 577 KLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASG 636
           K    K  R    +  + + +  K   +  D    ++SK+   E   ++S G    P+S 
Sbjct: 742 KNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKPKTED--KNSAGHK--PSSN 797

Query: 637 SACSGLNKQEPGGSHGSETEDTGRSLPSK--KERSGKSHRHKKKKKHKKSSKHKRKHKAD 694
              S   KQ             G  +PSK  K   G   R   +    KSS +  K  + 
Sbjct: 798 RESS---KQSAAKEKDLLPSPAG-PVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKETSG 853

Query: 695 TEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDD 753
           + + SS     +K++ +     K+ K  AP+ S   P   P    S   PRR +   DD
Sbjct: 854 SSKNSSSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTLDSSK--PRRTKLVFDD 910


>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
            containing B [Homo sapiens]
          Length = 546

 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 75/338 (22%), Positives = 136/338 (40%), Gaps = 29/338 (8%)

Query: 689  RKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRR 748
            RK K D +E + + +   + ++ +  +R  +   +P  S R       G GS +  R   
Sbjct: 238  RKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRS-RSRSHHREGHGSSSFDRELE 296

Query: 749  RAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSS 808
            R + + QR    A+E    ++      S S D G  +           RR+ ++   RS 
Sbjct: 297  R-EKERQRLEREAKEREKERRR-----SRSIDRGLER-----------RRSRSRERHRSR 339

Query: 809  HRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRR 868
             RS+   GD    D    + +++   +  + ++E  +  E  R RSR   +    R    
Sbjct: 340  SRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVE 399

Query: 869  SYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKY 928
                  D    +    ++ S  +  +S    R R+H  RS   +    + S+ + K  K+
Sbjct: 400  EKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKH 459

Query: 929  SSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSY 988
             +   + S   S+S S+ R+ + E+S+ R  S S   SR RS+            + RS+
Sbjct: 460  KNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSR-----------SKERSH 508

Query: 989  SRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFI 1026
             RD S S     +    R +S   ES E++H  + + +
Sbjct: 509  KRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDETV 546



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 78/348 (22%), Positives = 128/348 (36%), Gaps = 56/348 (16%)

Query: 644 KQEPGGSHGSETEDTGRSLPSKKERSGK-------SHRHKKKKKHKKSSKHKRKHKADTE 696
           K +  G  G+E  D  R +  ++ RS +       S R  + + H +          + E
Sbjct: 239 KIKKDGKEGAEEID--RHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELE 296

Query: 697 EKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQR 756
            +  +     ++K+R+K +R+        +  R    E   S S +  R+  R   D +R
Sbjct: 297 REKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRER 356

Query: 757 RSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSG 816
                +E   G++         +D    K +G       +R     +  RS    +    
Sbjct: 357 E----KENERGRR---------RDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKH 403

Query: 817 DEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDA 876
            ED DD    R H+       +E++   S S   + RSRS  R++  RS  RS   SS  
Sbjct: 404 KEDKDD----RRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKH 459

Query: 877 SSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYS 936
            ++    S +RS S       +D   +  KR H                           
Sbjct: 460 KNESKEKSNKRSRSGSQ--GRTDSVEKSKKREH--------------------------- 490

Query: 937 LSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQR 984
            S S+ +SR RS ++ERS  R  S S   S    +RRS+S    S ++
Sbjct: 491 -SPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEK 537



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 72/284 (25%), Positives = 104/284 (36%), Gaps = 34/284 (11%)

Query: 838  EEEEEEDSGSEHSRSRS--------RSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSY 889
            E  EE D   E  RSRS        RS RR  S    R  + SSS     +    RQR  
Sbjct: 246  EGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLE 305

Query: 890  SDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSH 949
             +    +   R  R   R  +   S  +  +HRS+        D       + +   R  
Sbjct: 306  REAKEREKERRRSRSIDRGLERRRSR-SRERHRSRSRSRDRKGDRRDRDREREKENERGR 364

Query: 950  TRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRS 1009
             R+R   + R       R RS+ RS+       QRSR    ++        +R    KR 
Sbjct: 365  RRDRDYDKERGNEREKERERSRERSKE------QRSRGEVEEKKHKEDKDDRRHRDDKRD 418

Query: 1010 WGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDD--SKATGPPSQN 1067
                  E++HS  R   R + +RS+S       R    GK+   R  +  SK      + 
Sbjct: 419  ---SKKEKKHSRSRS--RERKHRSRS-------RSRNAGKRSRSRSKEKSSKHKNESKEK 466

Query: 1068 SNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEE 1111
            SN  +  GS+G     +K+        E   S++  RK S S+E
Sbjct: 467  SNKRSRSGSQGRTDSVEKSKKR-----EHSPSKEKSRKRSRSKE 505



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 45/187 (24%), Positives = 74/187 (39%), Gaps = 14/187 (7%)

Query: 585 RTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNK 644
           + +G E+ K+   S +   +    GE  + K    +   R    + D+          ++
Sbjct: 372 KERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSR 431

Query: 645 QEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAES 704
           +    S         RS    KE+S K H+++ K+K  K S+   + + D+ EKS K E 
Sbjct: 432 ERKHRSRSRSRNAGKRSRSRSKEKSSK-HKNESKEKSNKRSRSGSQGRTDSVEKSKKREH 490

Query: 705 GEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEG 764
               +K +KR R K         ER  K +   S   +    RRR+Q   Q     ++E 
Sbjct: 491 SPSKEKSRKRSRSK---------ERSHKRDHSDSKDQSDKHDRRRSQSIEQE----SQEK 537

Query: 765 SSGKKDE 771
               KDE
Sbjct: 538 QHKNKDE 544


>gi|42741684 zinc finger protein 265 isoform 1 [Homo sapiens]
          Length = 330

 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 87/248 (35%), Positives = 110/248 (44%), Gaps = 44/248 (17%)

Query: 763  EGSSGKKDEGGGGSSSQDHGGRKHKGE-LPPSSCQRRAGTKRSSRSSHRSQPSSG----- 816
            E S G+ DE G          +K++G+ + P+S  +    K S                 
Sbjct: 118  EESDGEYDEFGRKK-------KKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKYKLD 170

Query: 817  -DEDSDDASSHRLHQKSPSQYS-EEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSS 874
             DED DDA          S+Y+ +  EEEDS  + S  RSRS  R S  RSS RS S SS
Sbjct: 171  EDEDEDDADL--------SKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSS 222

Query: 875  DASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDD 934
              S      SR RS S  S    S  S R   RS  S       S+  S+ H+ SSS   
Sbjct: 223  SRSR-----SRSRSRSSSSSQSRSRSSSRERSRSRGS------KSRSSSRSHRGSSSPRK 271

Query: 935  YSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSR 994
             S S S S       + ER+R R RSRSSS S  R KRR+RS +    +R RS S     
Sbjct: 272  RSYSSSSS-------SPERNRKRSRSRSSS-SGDRKKRRTRSRSPE--RRHRSSSGSSHS 321

Query: 995  STRSPSQR 1002
             +RS S++
Sbjct: 322  GSRSSSKK 329



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 66/220 (30%), Positives = 93/220 (42%), Gaps = 15/220 (6%)

Query: 829  HQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRS------SRRSYSSSSDASSDQSC 882
            +++   +Y E EE +    E  R + +   +     S       + S     D   D S 
Sbjct: 107  NERENVEYIEREESDGEYDEFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSK 166

Query: 883  YSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQS 942
            Y       +D   D +D S+ +   S + D     S+K +S R   S S   +S S S+S
Sbjct: 167  YK----LDEDEDEDDADLSKYNLDASEEED-----SNKKKSNRRSRSKSRSSHSRSSSRS 217

Query: 943  RSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQR 1002
             S S S +R RSRSR  S S S SRS S+ RSRS  + S   SRS+    S   RS S  
Sbjct: 218  SSPSSSRSRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPRKRSYSSS 277

Query: 1003 SGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSG 1042
            S S +R+          SG R   R++    +  H   SG
Sbjct: 278  SSSPERNRKRSRSRSSSSGDRKKRRTRSRSPERRHRSSSG 317



 Score = 74.3 bits (181), Expect = 8e-13
 Identities = 73/214 (34%), Positives = 97/214 (45%), Gaps = 25/214 (11%)

Query: 812  QPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYS 871
            + S G+ D       +   K+    S  +E ED  SE                S  +   
Sbjct: 118  EESDGEYDEFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDE------DEDLSKYKLDE 171

Query: 872  SSSDASSDQSCYSRQRSYSDDSYSDYSDR-SRRHSKRSH---DSDDSDYASSKHRSKRHK 927
               +  +D S Y+   S  +DS    S+R SR  S+ SH    S  S  +SS+ RS+   
Sbjct: 172  DEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRS 231

Query: 928  YSSSDDDYSLSCSQSRSRSRSHTRERSRSRG-RSRSSSCS-RSRSKRRSRSTTAHSWQRS 985
             SS         S S+SRSRS +RERSRSRG +SRSSS S R  S  R RS ++ S    
Sbjct: 232  RSS---------SSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPE 282

Query: 986  RSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERH 1019
            R+  R RSRS+ S  +    +KR     SPE RH
Sbjct: 283  RNRKRSRSRSSSSGDR----KKRRTRSRSPERRH 312



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 50/197 (25%), Positives = 81/197 (41%), Gaps = 15/197 (7%)

Query: 666 KERSGKSHRHKKKKKHKKSSKHKRKHKADTEE---KSSKAESGEKSKKRKKRKRKKNKSS 722
           KE   K    +++ + +  SK+K     D ++        ++ E+    KK+  ++++S 
Sbjct: 146 KEVEDKESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSK 205

Query: 723 APADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHG 782
           + +   R        S S +  R R R+   SQ RS      SS ++     GS S+   
Sbjct: 206 SRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRS-----RSSSRERSRSRGSKSRS-S 259

Query: 783 GRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEE 842
            R H+G   P   +R   +  SS   +R +  S    S D    R   +SP    E    
Sbjct: 260 SRSHRGSSSPR--KRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRTRSRSP----ERRHR 313

Query: 843 EDSGSEHSRSRSRSGRR 859
             SGS HS SRS S ++
Sbjct: 314 SSSGSSHSGSRSSSKKK 330



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 57/205 (27%), Positives = 81/205 (39%), Gaps = 29/205 (14%)

Query: 666 KERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRK--KRKRKKNKSSA 723
           KE  G+     +     K  + + +  AD  + +  A   E S K+K  +R R K++SS 
Sbjct: 151 KESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSH 210

Query: 724 PADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGG 783
              S R   P    S S +  R R R+   SQ RS      SS ++     GS S+    
Sbjct: 211 SRSSSRSSSP----SSSRSRSRSRSRSSSSSQSRSR-----SSSRERSRSRGSKSRS-SS 260

Query: 784 RKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEE 843
           R H+G   P   +R   +  SS   +R +  S    S D    R   +SP +        
Sbjct: 261 RSHRGSSSPR--KRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRTRSRSPER-------- 310

Query: 844 DSGSEHSRSRSRSGRRHSSHRSSRR 868
                  R RS SG  HS  RSS +
Sbjct: 311 -------RHRSSSGSSHSGSRSSSK 328



 Score = 54.3 bits (129), Expect = 9e-07
 Identities = 78/329 (23%), Positives = 114/329 (34%), Gaps = 28/329 (8%)

Query: 569 CNPLYFDFKLSRNKDARTKGTEKPK------DIGSSSKDHLQGLDPGEPNKSKEVGGEKI 622
           C  + F  + S N+  R K TE         +IG +  +  +GL      + K       
Sbjct: 20  CGNVNFARRTSCNRCGREKTTEAKMMKAGGTEIGKTLAEKSRGLFSANDWQCKTCSNVNW 79

Query: 623 VRSSGGRM-DAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRH-KKKKK 680
            R S   M + P           +E  G  G   E        ++E  G+     +KKKK
Sbjct: 80  ARRSECNMCNTPKYAKL------EERTGYGGGFNERENVEYIEREESDGEYDEFGRKKKK 133

Query: 681 HKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERG--PKPEPPGS 738
           ++  +        + E+K S+ E  ++ +   K K  +++    AD  +      E   S
Sbjct: 134 YRGKAVGPASILKEVEDKESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDS 193

Query: 739 GSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRR 798
                 RR R     S  RS       S  +      S S      + +     SS +R 
Sbjct: 194 NKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRS----SSRERS 249

Query: 799 AGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGR 858
                 SRSS RS   S        SS R    S S  S E   + S S  S S  R  R
Sbjct: 250 RSRGSKSRSSSRSHRGS--------SSPRKRSYSSSSSSPERNRKRSRSRSSSSGDRKKR 301

Query: 859 RHSSHRSSRRSYSSSSDASSDQSCYSRQR 887
           R  S    RR  SSS  + S     S+++
Sbjct: 302 RTRSRSPERRHRSSSGSSHSGSRSSSKKK 330


>gi|158854042 hypothetical protein LOC222183 [Homo sapiens]
          Length = 653

 Score = 81.3 bits (199), Expect = 7e-15
 Identities = 125/503 (24%), Positives = 178/503 (35%), Gaps = 102/503 (20%)

Query: 646  EPGGSHGSETEDTGR---SLPSKKERSGKSHRHK-----------KKKKHKK-------- 683
            EPG  +    +D G      P+   R  + +R K           KKKK KK        
Sbjct: 124  EPGLEYAPFDDDDGPVDCDCPASCYRGHRGYRTKHWSSSSASPPPKKKKKKKGGHRRSRK 183

Query: 684  ------------SSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGP 731
                        SS  ++K K+  + +  +++SG + K+R + +  K K       ++ P
Sbjct: 184  KRRLESECSCGSSSPLRKKKKSVKKHRRDRSDSGSRRKRRHRSRSSKCKRKEKNKEKKRP 243

Query: 732  KPEPPG--------------------SGSPAPPRRRRRAQDD-----SQRRS---LPAEE 763
              E PG                    S S +P R   + +D+     SQR S    P+  
Sbjct: 244  HTESPGRRSHRHSSGSSHSPSLSSHYSDSRSPSRLSPKHRDEGRKTGSQRSSGSRSPSPS 303

Query: 764  GSSG---KKDEGGGGSSSQDHGGRKHKGELP---PSSCQRRAGTKRSSRS---------- 807
            G SG    +  GG G  S  HGGR      P   PSS   R   K ++ +          
Sbjct: 304  GGSGWGSPQRNGGSGQRSGAHGGRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPPARGKES 363

Query: 808  -SHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSS 866
             S RS PSS       A      ++   +         +     R R R      S RS 
Sbjct: 364  PSPRSAPSSQGRGGRAAGGAGRRRRRRRRRRRSRSSASAPRRRGRRRPRPAPPRGSSRSL 423

Query: 867  RRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHR---- 922
             R+ SSS   S   +        S+  +  +  R++    R+  +  S    +  R    
Sbjct: 424  SRARSSSDSGSGRGAPGPGPEPGSERGHGGHGKRAKERPPRARPASTSPSPGAHGRRGGP 483

Query: 923  -SKRHKYSSSDDDYSLSCSQSRSRSRSHTRE-RSRSRGRSRSSSCSRSRSK------RRS 974
              K    S      S S S+S S+SRS + E R  S  RS S     SR K      R S
Sbjct: 484  EGKSSSRSPGPHPRSWSSSRSPSKSRSRSAEKRPHSPSRSPSPKKPLSRDKDGEGRARHS 543

Query: 975  RSTTAHSWQRSRSYSRDRSRSTRSPS-----QRSGSRKRSWGHESPEERHSG---RRDFI 1026
             +    + +RSRSYS  R R   SPS     + + +RKR   +  P    S      D+ 
Sbjct: 544  EAEATRARRRSRSYSPIRKRRRDSPSFMEPRRITSARKRPIPYYRPSPSSSSSCLSSDYS 603

Query: 1027 RSKIYRSQSP---HYFRSGRGEG 1046
                 RS SP   H   S R  G
Sbjct: 604  TRSHSRSPSPGHSHGSYSSRSHG 626



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 128/513 (24%), Positives = 180/513 (35%), Gaps = 98/513 (19%)

Query: 608  PGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPG-GSHGSETEDTG------- 659
            P    K K+ GG +  R    R+++  S  + S L K++     H  +  D+G       
Sbjct: 166  PPPKKKKKKKGGHRRSRKKR-RLESECSCGSSSPLRKKKKSVKKHRRDRSDSGSRRKRRH 224

Query: 660  RSLPSKKERSGK---------------SHRHKKKKKHKKS-----------SKHKRKHKA 693
            RS  SK +R  K               SHRH     H  S           S+   KH+ 
Sbjct: 225  RSRSSKCKRKEKNKEKKRPHTESPGRRSHRHSSGSSHSPSLSSHYSDSRSPSRLSPKHRD 284

Query: 694  DTEEKSSKAESGEKS-------------------KKRKKRKRKKNKSSAPADSERGPKPE 734
            +  +  S+  SG +S                   ++      +   + +P D    P P 
Sbjct: 285  EGRKTGSQRSSGSRSPSPSGGSGWGSPQRNGGSGQRSGAHGGRPGSAHSPPDKPSSPSPR 344

Query: 735  PPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSS 794
                 + A P    R ++    RS P+ +G  G+     GG+  +    R+ +     +S
Sbjct: 345  VRDKAAAAAPTPPARGKESPSPRSAPSSQGRGGR---AAGGAGRRRRRRRRRRRSRSSAS 401

Query: 795  CQRRAGTKRSSRSSHR--SQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRS 852
              RR G +R   +  R  S+  S    S D+ S R    +P    E   E   G    R+
Sbjct: 402  APRRRGRRRPRPAPPRGSSRSLSRARSSSDSGSGR---GAPGPGPEPGSERGHGGHGKRA 458

Query: 853  RSRSGRRHSSHRS----SRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRS 908
            + R  R   +  S    +          SS +S     RS+S  S S    RSR   KR 
Sbjct: 459  KERPPRARPASTSPSPGAHGRRGGPEGKSSSRSPGPHPRSWS-SSRSPSKSRSRSAEKRP 517

Query: 909  HDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRS 968
            H         S  RS   K   S D           R+R    E +R+R RSRS S  R 
Sbjct: 518  H---------SPSRSPSPKKPLSRD------KDGEGRARHSEAEATRARRRSRSYSPIRK 562

Query: 969  RSK------RRSRSTTAHSWQRSRSYSRDRSRSTRS-----PSQRSGSRKRSWGHE--SP 1015
            R +         R T+A   +R   Y R    S+ S      S RS SR  S GH   S 
Sbjct: 563  RRRDSPSFMEPRRITSAR--KRPIPYYRPSPSSSSSCLSSDYSTRSHSRSPSPGHSHGSY 620

Query: 1016 EERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPG 1048
              R  G R   RS   R+ SP Y      E  G
Sbjct: 621  SSRSHGTRSRTRSP-SRTPSPSYHSRSSSESGG 652



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 113/453 (24%), Positives = 146/453 (32%), Gaps = 87/453 (19%)

Query: 875  DASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDD 934
            D     SCY   R Y    +S  S       K+             HR  R K     + 
Sbjct: 140  DCDCPASCYRGHRGYRTKHWSSSSASPPPKKKKKKKGG--------HRRSRKKRRLESEC 191

Query: 935  YSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTA------------HSW 982
               S S  R + +S  + R     R RS S SR + + RSRS+              H+ 
Sbjct: 192  SCGSSSPLRKKKKSVKKHR-----RDRSDSGSRRKRRHRSRSSKCKRKEKNKEKKRPHTE 246

Query: 983  QRSRSYSRDRSRSTRSPSQRSG-SRKRSWGHESPEERHSGRR-DFIRSKIYRSQSPHYFR 1040
               R   R  S S+ SPS  S  S  RS    SP+ R  GR+    RS   RS SP    
Sbjct: 247  SPGRRSHRHSSGSSHSPSLSSHYSDSRSPSRLSPKHRDEGRKTGSQRSSGSRSPSP---S 303

Query: 1041 SGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSR 1100
             G G G  +++ G G  S A G          GR      SP DK S           S 
Sbjct: 304  GGSGWGSPQRNGGSGQRSGAHG----------GRPGSAH-SPPDKPS---------SPSP 343

Query: 1101 KVERKPSVSEEVQATPNKAGPKLKDPP--QGYFGPKLPPSLGNKPVLPLIGKLPATRKPN 1158
            +V  K + +        K  P  +  P  QG  G     +          G+    R+  
Sbjct: 344  RVRDKAAAAAPTPPARGKESPSPRSAPSSQGRGGRAAGGA----------GRRRRRRRRR 393

Query: 1159 KKCEESGLERGEEQEQSETEEGPPGSSDALFGHQFPSEE-----TTGPLLDPPPEESKSG 1213
            ++   S         +      P GSS +L   +  S+        GP  +P  E    G
Sbjct: 394  RRSRSSASAPRRRGRRRPRPAPPRGSSRSLSRARSSSDSGSGRGAPGPGPEPGSERGHGG 453

Query: 1214 EATADHPVAPLGTPAHSDCYPGDPTISHNYLPDPSDGDTLESLDSSSQPGP----VESSL 1269
                     P   PA +   PG    +H     P      E   SS  PGP      SS 
Sbjct: 454  HGKRAKERPPRARPASTSPSPG----AHGRRGGP------EGKSSSRSPGPHPRSWSSSR 503

Query: 1270 LP------IAPDLEHFPSYAPPSGDPSIESTDG 1296
             P       A    H PS +P    P     DG
Sbjct: 504  SPSKSRSRSAEKRPHSPSRSPSPKKPLSRDKDG 536



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 95/425 (22%), Positives = 149/425 (35%), Gaps = 74/425 (17%)

Query: 792  PSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSR 851
            P+SC R     R  R+ H S  S+             H++S  +   E E     S   R
Sbjct: 144  PASCYRG---HRGYRTKHWSSSSASPPPKKKKKKKGGHRRSRKKRRLESECSCGSSSPLR 200

Query: 852  SRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDS 911
             + +S ++H   RS   S       S    C  ++++              +  KR H  
Sbjct: 201  KKKKSVKKHRRDRSDSGSRRKRRHRSRSSKCKRKEKN--------------KEKKRPHTE 246

Query: 912  DDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGR---SRSSSCSRS 968
                  S   RS RH  S S    SLS   S SRS S    + R  GR   S+ SS SRS
Sbjct: 247  ------SPGRRSHRHS-SGSSHSPSLSSHYSDSRSPSRLSPKHRDEGRKTGSQRSSGSRS 299

Query: 969  -------------RSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQR-----SGSRKRSW 1010
                         R+    + + AH  +   ++S     S+ SP  R     +     + 
Sbjct: 300  PSPSGGSGWGSPQRNGGSGQRSGAHGGRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPPAR 359

Query: 1011 GHESPEERH--------------SGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGD 1056
            G ESP  R               +GRR   R +  RS+S       RG    +    RG 
Sbjct: 360  GKESPSPRSAPSSQGRGGRAAGGAGRRRRRRRRRRRSRSSASAPRRRGRRRPRPAPPRG- 418

Query: 1057 DSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATP 1116
             S++      +S+ G+GRG+ G   PE  +             ++ + +P  +     +P
Sbjct: 419  SSRSLSRARSSSDSGSGRGAPGP-GPEPGSERG-----HGGHGKRAKERPPRARPASTSP 472

Query: 1117 NKAGPKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNKKCEESGLERGEEQEQSE 1176
            +      +  P+G    + P         P      ++R P+K    S  +R     +S 
Sbjct: 473  SPGAHGRRGGPEGKSSSRSPG--------PHPRSWSSSRSPSKSRSRSAEKRPHSPSRSP 524

Query: 1177 TEEGP 1181
            + + P
Sbjct: 525  SPKKP 529


>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
          Length = 1564

 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 143/720 (19%), Positives = 248/720 (34%), Gaps = 108/720 (15%)

Query: 462  SEQPKETSMTEPSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLATP 521
            S+ PK  S  + S    K     A+   + DQ   S           ++N SK+      
Sbjct: 216  SKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNS-----------KTNQSKK------ 258

Query: 522  AGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRN 581
                  +GP+ P+ P  P + +D +   ++  +  +  + E   +        DF+  R 
Sbjct: 259  ------KGPRTPSPP--PPIPEDIALGKKYKEKYKVKDRIEEK-TRDGKDRGRDFERQRE 309

Query: 582  KDARTKGTEKPKDIGS--SSKDHLQGLDPGEP----------NKSKEVGGEKIVRSSGGR 629
            K  + + T       S  SS+ H      G             ++     ++ +     R
Sbjct: 310  KRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRR 369

Query: 630  MDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSH--RHKK------KKKH 681
              +P    + S   +++    H S   + GR      ER+ +SH  RH++      K+  
Sbjct: 370  SASPYPSHSLSSPQRKQSPPRHRSPMREKGRH---DHERTSQSHDRRHERREDTRGKRDR 426

Query: 682  KKSSKHKRKHKADTEEKSSKAESGEKSKKRKKR-------KRKKNKSSAPADSE--RGPK 732
            +K S+ +R+++ D        +  E    R +R       +R+   S    DS   R   
Sbjct: 427  EKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYS 486

Query: 733  PEPPGSGSPAPPRRRRRAQD-------DSQRR--SLPAEEGSSGK------------KDE 771
             +   S  P   R  R A D       D+ R+  + P E  S G+            ++E
Sbjct: 487  RDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNE 546

Query: 772  GGGGSSSQDHGGR--KHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLH 829
                S S+    R  + +G +P    +   G++ S   SH S  S+  +  +  SS+   
Sbjct: 547  SRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSN-SNYHDSWETRSSYPER 605

Query: 830  QKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSR--RSYSSSSDASSDQSCYSRQR 887
             + P + + ++  + S       R R   R    R S   R    + +   D+    R+ 
Sbjct: 606  DRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDE----RRE 661

Query: 888  SYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSR 947
                D   D  D   R   R  + D       +    R +    + +   +  + R R +
Sbjct: 662  ERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREK 721

Query: 948  SHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRK 1007
               RER R R   R     R R + + R       +R R   R+R R      +R+  R 
Sbjct: 722  ERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARERD 781

Query: 1008 RSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKK---DDGRGDDSKAT--- 1061
            +    +   E     RD  R K    +     R G  E   KK   ++G     ++    
Sbjct: 782  KERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRR 841

Query: 1062 ---GPPSQNSNIGTGRGSEGD-----CSPEDKNSVTAKLLLE------KIQSRKVERKPS 1107
                P S   N G  +  +         P++  S++   L E      K + RK ERK S
Sbjct: 842  REHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKES 901



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 134/704 (19%), Positives = 240/704 (34%), Gaps = 73/704 (10%)

Query: 575  DFKLSRNKDARTKGTEKPKDIGSSSKDHLQG------LDPGEPNKSK-EVGGEKIVRSSG 627
            D++    +D   K    P++  S  ++HL+       +     N+S+ E+  +++ RS G
Sbjct: 506  DYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRG 565

Query: 628  GRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKS--S 685
               + P  GS  S    Q    S  S   D+  +  S  ER     R  + +    S   
Sbjct: 566  RVPELPEKGSRGSR-GSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFER 624

Query: 686  KHKRKHKADTEEKSSKAESGEKSKKR----KKRKRKKNKSSAPADSERGPKPEPPGSGSP 741
            +H  + + D  E+  +  S  + + R    ++ +R++ +     D  R  +         
Sbjct: 625  RHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDER--------- 675

Query: 742  APPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGT 801
            A  R R R +D  + R    E     +K+       +++    + K E      + R   
Sbjct: 676  ARERDRERERDRERERERERERDREREKERELERERAREREREREK-ERDRERDRDRDHD 734

Query: 802  KRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHS 861
            +   R   R +    + + ++    R  ++   +  E E E     +  R R R      
Sbjct: 735  RERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKD 794

Query: 862  SHRSSRRSYSSS-----SDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDY 916
              R  RR          +         S++R  ++ S S      RR   R H  D   Y
Sbjct: 795  KGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRR---REHSPDSDAY 851

Query: 917  ASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRS 976
             S   ++++H+  S      +   +SRS S SH  E  + R +       R  S RR   
Sbjct: 852  NSGDDKNEKHRLLSQ----VVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEE 907

Query: 977  TTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRR--DFIRSKIYRSQ 1034
                    S    R+++    S   R+   +   GH   E+R +  R  D  + K    +
Sbjct: 908  QELKEKVSSVDKQREQTEILESSRMRA---QDIIGHHQSEDRETSDRAHDENKKKAKIQK 964

Query: 1035 SPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLL 1094
             P            KK+D  G          +  NI T        SP  K     K + 
Sbjct: 965  KPI---------KKKKEDDVG---------IERGNIETTSEDGQVFSP--KKGQKKKSIE 1004

Query: 1095 EKIQSRKVERKPSVSEEVQATPNKAGPKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPAT 1154
            +K +  K +   S  E  Q +  K             GP+ PP    + ++ +       
Sbjct: 1005 KKRKKSKGDSDISDEEAAQQSKKKR------------GPRTPPITTKEELVEMCNGKNGI 1052

Query: 1155 RKPNKKCEESGLERGEEQEQSETEEGPPGSSDALFGHQFPSEETTGPLLDPPPEESKSGE 1214
             + ++K E++      +++  +  E       A       +      LL PPP  + +  
Sbjct: 1053 LEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATATA 1112

Query: 1215 ATADHPVAPLGTPAHSDCYPGDPTISHNYLPDPSDGDTLESLDS 1258
             T    +A     A +       TIS +  P  +  +T  + DS
Sbjct: 1113 TTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDS 1156



 Score = 60.8 bits (146), Expect = 9e-09
 Identities = 92/419 (21%), Positives = 155/419 (36%), Gaps = 34/419 (8%)

Query: 640  SGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKS 699
            S +  Q+  G H SE  +T      + ++  K  +   KKK K+      +   +T  + 
Sbjct: 930  SRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKK-KEDDVGIERGNIETTSED 988

Query: 700  SKAESGEKSKKRK--KRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRR 757
             +  S +K +K+K  ++KRKK+K  +    E   +      G   PP   +    +    
Sbjct: 989  GQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNG 1048

Query: 758  SLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQP---S 814
                 E S  K+D      S +D   R    E   ++     G+  S  SS    P   +
Sbjct: 1049 KNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVA 1108

Query: 815  SGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSS 874
            +    +  A+       + + +S       + +  + + + +     SHR   R+     
Sbjct: 1109 TATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVEKV 1168

Query: 875  DA-----SSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRS--KRHK 927
            +         Q      +  S    S+ S+RS    +    S+DS + S   +S  KR  
Sbjct: 1169 ETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVL 1228

Query: 928  YSSSDD---DYSLSCSQSR------------SRSRSHTRERSRSRGRSRSSSCSRSRSKR 972
            +S S D     SL  +  R            SRS S  R+ SRS    RSS      S R
Sbjct: 1229 HSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSS----PESDR 1284

Query: 973  RSRSTTAHSWQRSRSYSRDRSRSTRS-PSQRSGSRKRSWGHESPEERHSGR-RDFIRSK 1029
            +  S +     R R   RDR    R    +R  +R+R W  ++ ++    R RD +R +
Sbjct: 1285 QVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRER 1343



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 98/460 (21%), Positives = 161/460 (35%), Gaps = 60/460 (13%)

Query: 643  NKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKK-HKKSSKHKRKHKADTEEKSSK 701
            NK++   +   +      S P +KE S   HR K+  K  K+ +    +   + E     
Sbjct: 91   NKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWETNRDD 150

Query: 702  AESGEKS----------KKRKKRKRKKNKSSAPADSERGP-----KPEPPGSGSPAPPRR 746
            +++G+ +           KR+K +R+  K       +R       +  P    S   P  
Sbjct: 151  SDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSP 210

Query: 747  RRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSR 806
              R    S +R    +  S+ KKD      SS            P    QR + T +S +
Sbjct: 211  SLRKSSKSPKRKSSPKSSSASKKDRKTSAVSS------------PLLDQQRNSKTNQSKK 258

Query: 807  SSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRS- 865
               R+ PS      +D +  + +++        EE+   G +  R   R   +    RS 
Sbjct: 259  KGPRT-PSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRST 317

Query: 866  ----------SRRSYSSSSDASSDQSCYS----RQRSYSDDSYSDYSDRSRR----HSKR 907
                      S R +SSSS + S    +S    R+R+ S       +   RR    +   
Sbjct: 318  SPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSH 377

Query: 908  SHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHT-----RERSRSRGRSRS 962
            S  S     +  +HRS   +    D + +      R   R  T     RE+     R   
Sbjct: 378  SLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYE 437

Query: 963  SSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGR 1022
               S SR  R  R       +R    +RDR     S   R     R +  ++ E R    
Sbjct: 438  QDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDP-- 495

Query: 1023 RDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATG 1062
            RD  RS    ++  H +R   G    +K+D   ++S++ G
Sbjct: 496  RD-SRS----TRDAHDYRDREGRDTHRKEDTYPEESRSYG 530



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 99/449 (22%), Positives = 149/449 (33%), Gaps = 44/449 (9%)

Query: 608  PGEPNKSKEVGGEK---IVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPS 664
            P +  K  +VG E+      S  G++ +P  G     + K+       S+  D   +  S
Sbjct: 966  PIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQS 1025

Query: 665  KKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAP 724
            KK+R  ++     K++  +    K     D+++K   A S    +    R          
Sbjct: 1026 KKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTA 1085

Query: 725  ADSERGPKPEPPGSGSPAPP--------------RRRRRAQDDSQRRSLPAEEGSSGKKD 770
              +  G  P P  S  P PP                   A   S   S      S+   +
Sbjct: 1086 TATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTN 1145

Query: 771  EGGGGSSSQD-----HGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASS 825
                  +++D     H  R  K E P  + +      R      RS     +  +   +S
Sbjct: 1146 TTNNTFANEDSHRKCHRTRVEKVETPHVTIED--AQHRKPMDQKRSSSLGSNRSNRSHTS 1203

Query: 826  HRLHQKSPSQYSEEEEEEDSGSE----HSRSRSR--------SGRRHSSHRSSRRSYSSS 873
             RL  +SPS  S     +D        HS SR R        +G R S     +R   S 
Sbjct: 1204 GRL--RSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSR 1261

Query: 874  SDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDD 933
            S +S  Q      RS+S    S  SDR       S DS D      ++   R +     D
Sbjct: 1262 STSSDRQD----SRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRD 1317

Query: 934  DYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRS-TTAHSWQRSRSYSRDR 992
                   +   +     R+R R R R R     + R   R R    + S +R R   RDR
Sbjct: 1318 TRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDR 1377

Query: 993  S-RSTRSPSQRSGSRKRSWGHESPEERHS 1020
            +  S++  S +    K    HE   E  S
Sbjct: 1378 TFESSQIESVKRCEAKLEGEHERDLESTS 1406



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 158/863 (18%), Positives = 297/863 (34%), Gaps = 115/863 (13%)

Query: 83   RMEMELDYAEDAT-ERRRVLEVEKEDTEELRQKYKDYVDKEKAIAKALEDLRANFYCELC 141
            R E  +D  +D   ER R  + E+E   E  ++ +   D+E+   + LE  RA       
Sbjct: 660  REERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARERERER 719

Query: 142  DKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSSRSRKDEKKQEKALRRLHELAE 201
            +K+  + ++ D   +      ++R ++ K+RE  R    R R+ E+++E+   R  E A 
Sbjct: 720  EKERDRERDRDRDHDRERERERERDRE-KEREREREERERERERERERERERERERERAR 778

Query: 202  QRKQAECAPGSGPMFKPTTVAVDEEGGEDDKDESATNSGTGATASCGLGSEFS----TDK 257
            +R +           +      D++ G DD+ E             G     S     ++
Sbjct: 779  ERDKER---------ERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNE 829

Query: 258  GGPFTAVQITNTTGLAQAPGLASQGISFGIKNNLGTPLQKLGVSFSFAKKAPVKLESIAS 317
            G P            +      + G     K+ L + + +           P +  S++ 
Sbjct: 830  GSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVR-----------PQESRSLSP 878

Query: 318  VFKDHAEEGT-SEDGTKPDEKSSDQGLQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSK 376
                   +G   E+  KP+ K S +  ++    +  S++D ++E  +          + +
Sbjct: 879  SHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTE----------ILE 928

Query: 377  LKRMKREEGAGATEPEYYHYIPPAH--CKVKPNFPFLLFMRASEQMDGDNTTHPKNAPES 434
              RM+ ++  G  + E       AH   K K         +  E   G    + +   E 
Sbjct: 929  SSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSED 988

Query: 435  KKGSSP----KPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSEP-------------- 476
             +  SP    K KS  K       +  +S+     +      P  P              
Sbjct: 989  GQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNG 1048

Query: 477  --GSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQEGPKHPT 534
              G   +++K      SD S E    +   T+  E  ++  T  +TP+   S   P  P 
Sbjct: 1049 KNGILEDSQKKEDTAFSDWSDEDVPDRTEVTE-AEHTATATTPGSTPSPLSSLLPPPPPV 1107

Query: 535  GPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTK----GTE 590
                   +   + A    +    F+ +  +IS S  P         N+D+  K      E
Sbjct: 1108 AT-ATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVE 1166

Query: 591  KPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRS-SGGRMDAPASGSACSGLNKQ---- 645
            K +    + +D  Q   P +  +S  +G  +  RS + GR+ +P++ SA    + Q    
Sbjct: 1167 KVETPHVTIED-AQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRK 1225

Query: 646  ----------------EPGGSHGSETEDTGRSLPSKKERS----GKSHRHKKKKKHKKSS 685
                            E  G   S  +   R  PS+   S     +SH  ++        
Sbjct: 1226 RVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQ 1285

Query: 686  KHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPR 745
             H R    D+ ++  + +  E  ++R++ +R   +     D+++    + P +      R
Sbjct: 1286 VHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADK----DWPRNRDRDRLR 1341

Query: 746  RRRRAQDDSQRRSLPAEE--------GSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQR 797
             R R ++  +RR L  E              +D      SSQ    ++ + +L     + 
Sbjct: 1342 ERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERD 1401

Query: 798  RAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSG 857
               T R S +  + +      D D  S     + + S+ +E  E  D         S+  
Sbjct: 1402 LESTSRDSLALDKER-----MDKDLGSVQGFEETNKSERTESLEAGD-------DESKLD 1449

Query: 858  RRHSSHRSSRRSYSSSSDASSDQ 880
              HS    +   Y   SD   D+
Sbjct: 1450 DAHSLGSGAGEGYEPISDDELDE 1472



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 96/417 (23%), Positives = 154/417 (36%), Gaps = 49/417 (11%)

Query: 684  SSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAP 743
            SS ++R  +  T +   + ++  +    + +KR   +SS+P   E               
Sbjct: 71   SSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESS------------- 117

Query: 744  PRRRRRAQDD---SQRRSLPAEEGS---SGKKDEGGGGSSSQDHGGRKHKGELPPSSCQR 797
             R R R ++D   ++ R+  +EE +      +D+   G  + D+   +   E+     QR
Sbjct: 118  -RGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDY-VHELSLEMKRQKIQR 175

Query: 798  RAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSG 857
                        R +     E S +    +L   SPS     +  +   S  S S S+  
Sbjct: 176  ELMKLEQENMEKREEIIIKKEVSPEVVRSKL-SPSPSLRKSSKSPKRKSSPKSSSASKKD 234

Query: 858  RRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSD------YSDRSR---RHSKRS 908
            R+ S+  S       +S  +  +    R  S       D      Y ++ +   R  +++
Sbjct: 235  RKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKT 294

Query: 909  HDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRS 968
             D  D      + R KR K  S+          S   SR H+     S  +S SS    S
Sbjct: 295  RDGKDRGRDFERQREKRDKPRSTS---PAGQHHSPISSRHHS-----SSSQSGSSIQRHS 346

Query: 969  RSKRRSRSTTAHSWQRSRSYSRDRSRST-RSPSQRSGSRKRSWGHESPEERHSGRRDFIR 1027
             S RR R T + S+QR+ +    RS S   S S  S  RK+S        R  GR D  R
Sbjct: 347  PSPRRKR-TPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHER 405

Query: 1028 SKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPED 1084
            +    SQS       R +  GK+D  R  DS+      Q+ +  + R    D  P D
Sbjct: 406  T----SQSHDRRHERREDTRGKRD--REKDSREEREYEQDQS--SSRDHRDDREPRD 454


>gi|38146113 arginine/serine-rich coiled-coil 2 isoform b [Homo
            sapiens]
          Length = 375

 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 67/187 (35%), Positives = 88/187 (47%), Gaps = 28/187 (14%)

Query: 855  RSGRRHSSH-RSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDD 913
            + GRRH S  +SS++  S   +     S   R+R  S ++  D   R  R S R      
Sbjct: 9    KQGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRS--- 65

Query: 914  SDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRR 973
              ++ S+ R +RH+          S S+ R +SRS +RER +SR RSR    SRSRS+ R
Sbjct: 66   --HSRSRSRERRHR----------SRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRER 113

Query: 974  SRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRS 1033
             R   + S  RSR   R RSRS      RS SR R    E P       R F RS + R+
Sbjct: 114  KRRIRSRSRSRSRHRHRTRSRS----RTRSRSRDRKKRIEKP-------RRFSRS-LSRT 161

Query: 1034 QSPHYFR 1040
             SP  FR
Sbjct: 162  PSPPPFR 168



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 66/223 (29%), Positives = 93/223 (41%), Gaps = 41/223 (18%)

Query: 797  RRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRS 856
            RR  +K  S   H+S+  +  E S D    RL+       SE  E+     E   SR   
Sbjct: 12   RRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNS------SENGEDRHKRKERKSSR--- 62

Query: 857  GRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDY 916
            GR HS  RS  R + S           SR+R  S         RSR   ++   S   + 
Sbjct: 63   GRSHSRSRSRERRHRSR----------SRERKKS---------RSRSRERKKSRSRSRER 103

Query: 917  ASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRS 976
              S+ RS+  K             + RSRSRS +R R R+R RSR+ S SR R KR  + 
Sbjct: 104  KKSRSRSRERK------------RRIRSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKP 151

Query: 977  TT-AHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEER 1018
               + S  R+ S    R R+T   +Q + +R+     +  E+R
Sbjct: 152  RRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQR 194



 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 40/187 (21%), Positives = 73/187 (39%), Gaps = 25/187 (13%)

Query: 574 FDFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAP 633
           F  K  R  +++ K ++K K    + K+H           S + G E++  S  G     
Sbjct: 6   FFLKQGRRHESKDKSSKKHKSEEHNDKEH-----------SSDKGRERLNSSENGEDRHK 54

Query: 634 ASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKA 693
                     K   G SH        R     +ER     R +++KK +  S+ ++K ++
Sbjct: 55  RKE------RKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRS 108

Query: 694 DTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPG------SGSPAPP--R 745
            + E+  +  S  +S+ R + + +    +     +R  + E P       S +P+PP  R
Sbjct: 109 RSRERKRRIRSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFR 168

Query: 746 RRRRAQD 752
            R  A D
Sbjct: 169 GRNTAMD 175



 Score = 44.7 bits (104), Expect = 7e-04
 Identities = 40/132 (30%), Positives = 57/132 (43%), Gaps = 8/132 (6%)

Query: 746 RRRRAQDDSQRRSLPAEEGSSG-KKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRS 804
           RR  ++D S ++    E        D+G    +S ++G  +HK +   SS  R     RS
Sbjct: 12  RRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRS 71

Query: 805 SRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSR---SRSRSGRRHS 861
               HRS+     E     S  R  +KS S+  E ++      E  R   SRSRS  RH 
Sbjct: 72  RERRHRSRSR---ERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRH- 127

Query: 862 SHRSSRRSYSSS 873
            HR+  RS + S
Sbjct: 128 RHRTRSRSRTRS 139



 Score = 40.4 bits (93), Expect = 0.013
 Identities = 46/237 (19%), Positives = 80/237 (33%), Gaps = 37/237 (15%)

Query: 769  KDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRL 828
            KD+      S++H  ++H  +      + R  +  +    H+ +          + S   
Sbjct: 17   KDKSSKKHKSEEHNDKEHSSD----KGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSR 72

Query: 829  HQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRS 888
             ++  S+  E ++      E  +SRSRS  R  S   SR            +   SR RS
Sbjct: 73   ERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSR---------ERKRRIRSRSRS 123

Query: 889  YSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRS 948
             S            RH  RS     S    S+ R KR           +   +  SRS S
Sbjct: 124  RS----------RHRHRTRSRSRTRS---RSRDRKKR-----------IEKPRRFSRSLS 159

Query: 949  HTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGS 1005
             T      RGR+ +     + ++R  R+      +      + + +   + +   GS
Sbjct: 160  RTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQEIAAAAATGGS 216



 Score = 37.4 bits (85), Expect = 0.11
 Identities = 51/211 (24%), Positives = 88/211 (41%), Gaps = 41/211 (19%)

Query: 643 NKQEPGGSHGSETE-DTGRSLPSKKER--SGKSHRHKKKKKHKKSSKHKRKHKADTEEKS 699
           +K +    H SE   D   S    +ER  S ++   + K+K +KSS+ +   ++ + E+ 
Sbjct: 16  SKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERR 75

Query: 700 SKAESGEKSKKR---KKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQR 756
            ++ S E+ K R   ++RK+ +++S     S    +             R+RR +  S+ 
Sbjct: 76  HRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSR------------ERKRRIRSRSRS 123

Query: 757 RSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRS---QP 813
           RS       S  +      S S+D   RK + E P          +R SRS  R+    P
Sbjct: 124 RSRHRHRTRSRSRTR----SRSRD---RKKRIEKP----------RRFSRSLSRTPSPPP 166

Query: 814 SSGDE---DSDDASSHRLHQKSPSQYSEEEE 841
             G     D+ +A + RL +    Q   E+E
Sbjct: 167 FRGRNTAMDAQEALARRLERAKKLQEQREKE 197


>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
          Length = 2454

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 166/746 (22%), Positives = 273/746 (36%), Gaps = 124/746 (16%)

Query: 333  KPDEKSSDQGLQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGAG----- 387
            K      D+G +K   S   S+ D KK         + +S +SK KR  + E +      
Sbjct: 730  KTQAGKDDKGKRKRKSSTSGSDFDTKKGKS------AKSSIISKKKRQTQSESSNYDSEL 783

Query: 388  ATEPEYYHYIPPAHCKVKPNFPFLLFMRASE-----QMDGDNTTHPKNAPESKKGSSPKP 442
              E +    I  A    K   P      +SE     +   DN  H KN   S++GSS   
Sbjct: 784  EKEIKSMSKIGAART-TKKRIPNTKDFDSSEDEKHSKKGMDNQGH-KNLKTSQEGSSDDA 841

Query: 443  KSCIKAAASQGAEKTVSEVSEQPKETSMTEPSEPGSKAEAKKALGGDVSDQSLESHSQKV 502
            +   +      AE TV       K+T++ E  +   K +   A    V   S +  S   
Sbjct: 842  ERKQERETFSSAEGTVD------KDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTS 895

Query: 503  SETQMCESNSSKETSLATPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAE 562
             E +       K   L T   K+ Q+G       F   L KD+S       +     +++
Sbjct: 896  LEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKF---LKKDQSDETSEDDK----KQSK 948

Query: 563  PSISYSCNPLYFD---FKLSRNKDARTKGTEK----------PKDIGSSSKDHLQGLDPG 609
                    P  F     K+ +  ++ + GTEK          PK I    K    G   G
Sbjct: 949  KGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGI----KQIKNGTTDG 1004

Query: 610  EPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERS 669
            E    K       +R    +     S  A     K    G     +ED       KK ++
Sbjct: 1005 EKKSKK-------IRDKTSKKKDELSDYAEKSTGK----GDSCDSSED-------KKSKN 1046

Query: 670  GKSHRHKKKKKHKKSSKHKRKH--KADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADS 727
            G   R KK+ K    S  KR+    +DTE+ S K +    S KR KR   + + +    S
Sbjct: 1047 GAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNL--SS 1104

Query: 728  ERGPKPEPPGSGSP-----APPRRRRRAQDDSQRRSLPAEEG-------SSGKKDEGGGG 775
            +R  K    GS S      +   ++++ +  S+++++  +E        S+ +K      
Sbjct: 1105 KRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITS 1164

Query: 776  SSSQD--HGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQ-PSSGDEDSDDASSHRLHQKS 832
            SSS D     +   GE      + +  T+    SSH     SSGDE         L +  
Sbjct: 1165 SSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDE--------ALSKSV 1216

Query: 833  PSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSD---QSCYSRQRSY 889
            P    +++++ D  +  ++               + + SS  D SSD   +    R    
Sbjct: 1217 PVTVDDDDDDNDPENRIAKKMLLE--------EIKANLSSDEDGSSDDEPEEGKKRTGKQ 1268

Query: 890  SDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSH 949
            ++++  D   +++ +S+   DS++S     +HR  RHK + SD +   S  + +++ + H
Sbjct: 1269 NEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGE---SGEEKKTKPKEH 1325

Query: 950  TRERSRSR----------------GRSRSSSCSRSRSKRRSRSTT-AHSWQRSRSYSRDR 992
               + R+R                G S   S S    + R+RS   A   +  RSY + +
Sbjct: 1326 KEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKK 1385

Query: 993  SRSTRSPSQRSGSRKRSWGHESPEER 1018
             R      + S S  +S   E  EE+
Sbjct: 1386 KRRRIKVQEDSSSENKSNSEEEEEEK 1411



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 158/811 (19%), Positives = 273/811 (33%), Gaps = 141/811 (17%)

Query: 226  EGGEDDKDESATNSGTGATASCGLGSEFSTDKGGPFTAVQITNTTGLAQAPGLASQGISF 285
            + G+DDK +    S T        GS+F T KG    +  I+      Q+    S     
Sbjct: 732  QAGKDDKGKRKRKSSTS-------GSDFDTKKGKSAKSSIISKKKRQTQSE---SSNYDS 781

Query: 286  GIKNNLGTPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGTSEDGTK----PDEKSSDQ 341
             ++  + + + K+G + +  K+ P   +  +S  + H+++G    G K      E SSD 
Sbjct: 782  ELEKEIKS-MSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDD 840

Query: 342  GLQK-----VGDSDGSSNLDG---KKEDEDPQDGGSLASTLSKLKRMKREEGAGATE--- 390
              +K        ++G+ + D    +  D  P+   + AST    K   +E+   + E   
Sbjct: 841  AERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRK 900

Query: 391  ----PEYYHYIPPAHCK-----VKPNFPFLLFMRASEQMDGDNTTHPKNAPESKKGSSPK 441
                 E   ++    CK     +       L    S++   D+    K   E KK  S  
Sbjct: 901  VAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDF 960

Query: 442  PKSCIKA-----AASQGAEKTVS--EVSEQPKETSMTEPSEPGSKAEAKKALGGDVSDQS 494
             K  IK      ++S G EK     E+   PK     +      + ++KK     + D++
Sbjct: 961  KKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKK-----IRDKT 1015

Query: 495  LESHSQKVSE-TQMCESNSSKETSLATPAGKESQEGPKHPTGPFFPVLSKDESTALQWPS 553
                S+K  E +   E ++ K  S  +   K+S+ G          +L K         S
Sbjct: 1016 ----SKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSS 1071

Query: 554  ELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNK 613
                    +     S +      +L   ++  +K   K    GSSS D  +  +  +  K
Sbjct: 1072 SDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKK 1131

Query: 614  SKEVGGEKIV----------RSSGGRMDAPASGSACSGLNKQEPGG-SHGSETED----- 657
             +    +K V          R+S  R  A  + S+ S +   +      GS  E      
Sbjct: 1132 QRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPV 1191

Query: 658  ---------TGRSLPSKKERSGKS----------HRHKKKKKHKKSSKHKRKHKADTEEK 698
                     TG    S  E   KS              + +  KK    + K    ++E 
Sbjct: 1192 TENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDED 1251

Query: 699  SSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRS 758
             S  +  E+ KKR  ++ ++N     A ++   + +     S  P  R R       R  
Sbjct: 1252 GSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLL-----RHK 1306

Query: 759  LPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDE 818
            L   +G SG+                           +++   K       R++     E
Sbjct: 1307 LTVSDGESGE---------------------------EKKTKPKEHKEVKGRNRRKVSSE 1339

Query: 819  DSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGR--------RHSSHRSSRRSY 870
            DS+D         S  Q S   EE     +  R R+RS +        R    +  RR  
Sbjct: 1340 DSED---------SDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRI 1390

Query: 871  SSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSS 930
                D+SS+    S +    ++   +  +      +   D +D   +  K R K  K   
Sbjct: 1391 KVQEDSSSENKSNSEE---EEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILK 1447

Query: 931  SDDDYSLSCSQSRSRSRSHTRERSRSRGRSR 961
              DD   + +Q+  +     R+R   R R R
Sbjct: 1448 --DDKLRTETQNALKEEEERRKRIAERERER 1476



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 96/470 (20%), Positives = 179/470 (38%), Gaps = 42/470 (8%)

Query: 649  GSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKS-SKAESGEK 707
            G    ++  +G    +KK +S KS    KKK+  +S       + + E KS SK  +   
Sbjct: 739  GKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAART 798

Query: 708  SKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRR-SLPAEEGSS 766
            +KKR    +  + S    + E+  K      G       +  + DD++R+        + 
Sbjct: 799  TKKRIPNTKDFDSS----EDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAE 854

Query: 767  GKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSH 826
            G  D+       +D   +K +         + +G ++S  S    + +   E S    + 
Sbjct: 855  GTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTK 914

Query: 827  --RLHQKSPSQYSE---EEEEEDSGSEHSRSRSRSGRRHSSHRSS--------RRSYSSS 873
              +  Q   S  +E   ++++ D  SE  + +S+ G       S          + Y SS
Sbjct: 915  TCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESS 974

Query: 874  SDASS-----DQSC-YSRQRSYSDDSYSDYSDRSRR-HSKRSHDSDD-SDYASSKHRSKR 925
            SD +      ++ C + +      +  +D   +S++   K S   D+ SDYA  K   K 
Sbjct: 975  SDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYA-EKSTGKG 1033

Query: 926  HKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRR-------SRSTT 978
                SS+D  S + +  R + R     +S  + +  SSS +   S +         R   
Sbjct: 1034 DSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKR 1093

Query: 979  AHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHY 1038
                +R    S+  ++  +S S  S + + S  ++  ++R S ++   ++ I + +  + 
Sbjct: 1094 IELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKK---KAVIVKEKKRNS 1150

Query: 1039 FRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSV 1088
             R+       K+ D     S       QNS IG G   E    P  +N V
Sbjct: 1151 LRTSTKR---KQADITSSSSSDIEDDDQNS-IGEGSSDEQKIKPVTENLV 1196



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 132/663 (19%), Positives = 221/663 (33%), Gaps = 103/663 (15%)

Query: 577  KLSRNKDARTKGTEKPKDIGSSSKDH--LQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPA 634
            ++   KD  +   EK    G  ++ H  L+    G  + ++     +   S+ G +D   
Sbjct: 802  RIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVD--- 858

Query: 635  SGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHK-- 692
              +    L  + P     S + D G    S KE+S  S   +K  + K+ SKH +     
Sbjct: 859  KDTTIMELRDRLPKKQQASASTD-GVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCK 917

Query: 693  ------ADTEEKSSKAESGEKSKKRKKRKRKKN--KSSAPADSERG-----PKPEPPGSG 739
                  +D  EK  K +  +++ +  K++ KK   +   P+D ++       + E    G
Sbjct: 918  KVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDG 977

Query: 740  SPAPPRRR------------RRAQDDSQRRSLPAEEGSSGKKDE-----------GGGGS 776
            +   P R             +    D +++S    + +S KKDE           G    
Sbjct: 978  TEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCD 1037

Query: 777  SSQDHGGRKHKGELPPSSCQR--RAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPS 834
            SS+D   +          C+   ++  KR   SS  ++  S  ED  ++S  RL      
Sbjct: 1038 SSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRL------ 1091

Query: 835  QYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSR--RSYSSSSDA--SSDQSCYSRQRSYS 890
                            R   R  R  SS R+++  +S SSSSDA  SS+ +   +QR+ S
Sbjct: 1092 ---------------KRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSS 1136

Query: 891  DDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRS-----KRHKYSSSDDDYSLSCSQSRSR 945
                    ++ R   + S     +D  SS         +      S D+  +        
Sbjct: 1137 KKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLV 1196

Query: 946  SRSHTRERSRSRGRSRSSSC---------SRSRSKRRSRSTTAHSWQRSRSYSRDRSRST 996
              SHT     S   + S S                R ++       + + S   D S   
Sbjct: 1197 LSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDD 1256

Query: 997  RSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGD 1056
                 +  + K++  +   EE  +       S    S+ P Y R           DG   
Sbjct: 1257 EPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRY-RHRLLRHKLTVSDGESG 1315

Query: 1057 DSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATP 1116
            + K T P       G  R        ED +                 ++  VSEEV  + 
Sbjct: 1316 EEKKTKPKEHKEVKGRNRRKVSSEDSEDSDF----------------QESGVSEEVSESE 1359

Query: 1117 NKAGPKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNKKCEESGLERGEEQEQSE 1176
            ++  P+ +   +         S   K     I     +   NK   E   E  EE+E+ E
Sbjct: 1360 DEQRPRTRSAKKAELEEN-QRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEE 1418

Query: 1177 TEE 1179
             EE
Sbjct: 1419 EEE 1421



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 79/442 (17%), Positives = 159/442 (35%), Gaps = 44/442 (9%)

Query: 677  KKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRK---RKKNKSSAPADSERGPKP 733
            ++    K++  +R  + +    +S  E  E  K+++K     RKK+K ++   +   PKP
Sbjct: 616  RRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKP 675

Query: 734  EPPGSGSPAPPRRRRRAQD---DSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGEL 790
                  +  P  ++    D   DS       +E S            ++ H   K   +L
Sbjct: 676  ------NKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDL 729

Query: 791  PPSSCQRRAGTKRSSRSSHRSQPSSGDEDS---DDASSHRLHQKSPSQYSEEEEEEDSGS 847
                 + +AG     +   +S  S  D D+     A S  + +K     SE    +    
Sbjct: 730  -----KTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELE 784

Query: 848  EHSRSRSRSGRRHSSHR--SSRRSYSSSSDA---------SSDQSCYSRQRSYSDDSYSD 896
            +  +S S+ G   ++ +   + + + SS D             ++  + Q   SDD+   
Sbjct: 785  KEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERK 844

Query: 897  YSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRS 956
                +   ++ + D D +         K+ + S+S D       + +S +    R+ + +
Sbjct: 845  QERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAET 904

Query: 957  RGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESP- 1015
            + +S+       +  +   S  A  + + +  S + S   +  S++    K+        
Sbjct: 905  KEKSKHLKTKTCKKVQDGLSDIAEKFLK-KDQSDETSEDDKKQSKKGTEEKKKPSDFKKK 963

Query: 1016 ----EERHSGRRDFIRSKIYRSQSPHY------FRSGRGEGPGKKDDGRGDDSKATGPPS 1065
                E+++    D       R +  H+       ++G  +G  K    R   SK     S
Sbjct: 964  VIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELS 1023

Query: 1066 QNSNIGTGRGSEGDCSPEDKNS 1087
              +   TG+G   D S EDK S
Sbjct: 1024 DYAEKSTGKGDSCD-SSEDKKS 1044



 Score = 40.8 bits (94), Expect = 0.010
 Identities = 44/243 (18%), Positives = 84/243 (34%), Gaps = 30/243 (12%)

Query: 627  GGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSK 686
            G   D P  G   +G   +E  G   ++ +    S    +E     +RH+  +       
Sbjct: 1252 GSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLR------- 1304

Query: 687  HKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRR 746
                HK    +  S  E   K K+ K+ K +  +  +  DSE     E   S   +    
Sbjct: 1305 ----HKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESED 1360

Query: 747  RRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSR 806
             +R +  S +++   E   S K+ +       Q+    ++K     S+ +     K    
Sbjct: 1361 EQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENK-----SNSEEEEEEKEEEE 1415

Query: 807  SSHRSQPSSGDEDSDDASS--------------HRLHQKSPSQYSEEEEEEDSGSEHSRS 852
                 +    ++++DD+ S               +L  ++ +   EEEE     +E  R 
Sbjct: 1416 EEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAERERE 1475

Query: 853  RSR 855
            R +
Sbjct: 1476 REK 1478



 Score = 37.7 bits (86), Expect = 0.084
 Identities = 91/432 (21%), Positives = 150/432 (34%), Gaps = 80/432 (18%)

Query: 654  ETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKK 713
            ET+      P   E+   S    K  + +  S+H  ++    E++++K+  GE     KK
Sbjct: 402  ETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGE----HKK 457

Query: 714  RKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGG 773
              RK+     PA++      +     S  P       +D  +      E  SS   D  G
Sbjct: 458  SDRKEEPQYEPANTSEDLDMDIVSVPSSVP-------EDIFENLETAMEVQSS--VDHQG 508

Query: 774  GGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRS-------------SHRSQPSSG---D 817
             GSS  +        +L  SS   R G K  + +             S  + P  G    
Sbjct: 509  DGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQ 568

Query: 818  EDSDDASSHRLHQKSPSQYSEEEEEEDSGSEH----------SRSRSRSGRRHSSHRSSR 867
            E   D   ++    +P        +E+S +EH            S  R   R  +    R
Sbjct: 569  EVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRR 628

Query: 868  RSYSSSSDASSDQSCYSR---------------QRSYSDDSYSDYSDRSRRHSKRSHDSD 912
             + ++   ++SD+ C                  +R+ SD +  +        SK+S   D
Sbjct: 629  PTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVD 688

Query: 913  ---DSD--YASSKHRSKRHKYSSSDDD-----------YSLSCSQSRSRSRSHTRERSRS 956
               DSD   A  K  S+    SSSD D           Y L     +       R+ S S
Sbjct: 689  QNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTS 748

Query: 957  -------RGRS-RSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKR 1008
                   +G+S +SS  S+ + + +S S+   S       S  +  + R+  +R  + K 
Sbjct: 749  GSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKD 808

Query: 1009 SWGHESPEERHS 1020
                 S +E+HS
Sbjct: 809  F--DSSEDEKHS 818


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.125    0.357 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,864,274
Number of Sequences: 37866
Number of extensions: 4140221
Number of successful extensions: 56431
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 587
Number of HSP's successfully gapped in prelim test: 1713
Number of HSP's that attempted gapping in prelim test: 25354
Number of HSP's gapped (non-prelim): 16350
length of query: 1502
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1387
effective length of database: 13,892,928
effective search space: 19269491136
effective search space used: 19269491136
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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