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Search of human proteins with 50845384
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50845384 ADAM metallopeptidase with thrombospondin type 1
motif, 1 preproprotein [Homo sapiens]
(967 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 2036 0.0
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 935 0.0
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 885 0.0
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 803 0.0
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 728 0.0
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 667 0.0
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 639 0.0
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 486 e-137
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 480 e-135
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 473 e-133
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 468 e-132
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 463 e-130
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 459 e-129
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 402 e-111
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 400 e-111
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 393 e-109
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 377 e-104
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 377 e-104
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 369 e-101
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 327 3e-89
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 327 3e-89
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 303 4e-82
gi|145309328 papilin [Homo sapiens] 233 8e-61
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 202 2e-51
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 202 2e-51
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 199 8e-51
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 175 2e-43
gi|226442878 ADAMTS-like 5 [Homo sapiens] 157 6e-38
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 147 5e-35
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 140 6e-33
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 2036 bits (5274), Expect = 0.0
Identities = 967/967 (100%), Positives = 967/967 (100%)
Query: 1 MQRAVPEGFGRRKLGSDMGNAERAPGSRSFGPVPTLLLLAAALLAVSDALGRPSEEDEEL 60
MQRAVPEGFGRRKLGSDMGNAERAPGSRSFGPVPTLLLLAAALLAVSDALGRPSEEDEEL
Sbjct: 1 MQRAVPEGFGRRKLGSDMGNAERAPGSRSFGPVPTLLLLAAALLAVSDALGRPSEEDEEL 60
Query: 61 VVPELERAPGHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDL 120
VVPELERAPGHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDL
Sbjct: 61 VVPELERAPGHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDL 120
Query: 121 AHCFYSGTVNGDPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAP 180
AHCFYSGTVNGDPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAP
Sbjct: 121 AHCFYSGTVNGDPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAP 180
Query: 181 LQFHLLRRNRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVG 240
LQFHLLRRNRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVG
Sbjct: 181 LQFHLLRRNRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVG 240
Query: 241 QPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRN 300
QPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRN
Sbjct: 241 QPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRN 300
Query: 301 SVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQD 360
SVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQD
Sbjct: 301 SVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQD 360
Query: 361 LCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASL 420
LCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASL
Sbjct: 361 LCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASL 420
Query: 421 NGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGT 480
NGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGT
Sbjct: 421 NGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGT 480
Query: 481 SYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWC 540
SYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWC
Sbjct: 481 SYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWC 540
Query: 541 INGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEG 600
INGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEG
Sbjct: 541 INGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEG 600
Query: 601 KRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKL 660
KRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKL
Sbjct: 601 KRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKL 660
Query: 661 ICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGN 720
ICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGN
Sbjct: 661 ICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGN 720
Query: 721 GSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILN 780
GSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILN
Sbjct: 721 GSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILN 780
Query: 781 GDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTY 840
GDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTY
Sbjct: 781 GDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTY 840
Query: 841 FVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPAS 900
FVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPAS
Sbjct: 841 FVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPAS 900
Query: 901 TRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDF 960
TRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDF
Sbjct: 901 TRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDF 960
Query: 961 CTMAECS 967
CTMAECS
Sbjct: 961 CTMAECS 967
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 935 bits (2417), Expect = 0.0
Identities = 480/983 (48%), Positives = 631/983 (64%), Gaps = 85/983 (8%)
Query: 36 LLLLAAALLAVSDALGRPSEEDEELVVP-ELE----------RAP---GHGTTRLRLHAF 81
+LLL LA + SE + E+VVP L+ R P G ++ AF
Sbjct: 1 MLLLGILTLAFAGRTAGGSEPEREVVVPIRLDPDINGRRYYWRGPEDSGDQGLIFQITAF 60
Query: 82 DQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSAAALSL 141
+ L L PD+ FLAP F+ +++G T +DL CFYSG VN +P S AA+SL
Sbjct: 61 QEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTG-GSSDLRRCFYSGDVNAEPDSFAAVSL 119
Query: 142 CEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNR-----QGDVGG 196
C G+RGAF G Y I PLP AS A AA A HLL+R GD
Sbjct: 120 CGGLRGAFGYRGAEYVISPLPNAS---APAAQRNSQGA----HLLQRRGVPGGPSGDPTS 172
Query: 197 TCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTG-SIRKKRFVS 255
CGV +A P P G G+ S R KRFVS
Sbjct: 173 RCGVASGWNPAILRA-----------------LDPYKPRRAGFGESRSRRRSGRAKRFVS 215
Query: 256 SHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDE 315
RYVET++VAD+SM +FHG+ L+HYLLTL + AARLY+HPSI N +++VVVK+L++ D
Sbjct: 216 IPRYVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDR 275
Query: 316 QKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMADV 375
GP+VT NAALTLRNFC WQK+ N SD+ E++DTAILFTRQDLCG+ TCDTLGMADV
Sbjct: 276 DSGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADV 335
Query: 376 GTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASMLS 435
GT+CDP RSCSVIEDDGL +AFTTAHELGHVFNMPHD+ K C + G + +HMM+ L
Sbjct: 336 GTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLI 395
Query: 436 NLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGED 495
+D + PWS CSA +IT FLD+GHG+CL+D+P PI LP DLPG SY ++QC+ FG
Sbjct: 396 QIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPISLPEDLPGASYTLSQQCELAFGVG 455
Query: 496 SKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKTD-RKHF 554
SK CP C+ LWCTG + G +VCQT+HFPWADGTSCGEGK C+ G CV + + KH
Sbjct: 456 SKPCP-YMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVERHNLNKH- 513
Query: 555 DTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCP 614
GSW W P+G CSRTCGGGVQ R+C NP P NGGKYCEG RV+YRSCNLE CP
Sbjct: 514 --RVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCP 571
Query: 615 DN-NGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVL 673
+ +GK+FREEQCEA N ++ ++ AV W+PKY+GVSP+D+CKLIC+A G GYF+VL
Sbjct: 572 SSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVL 631
Query: 674 QPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTS 733
PKVVDGT CSPDSTSVCVQG+C+KAGCD + SKK+FDKCGVCGG+ +CKK++G T
Sbjct: 632 APKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTK 691
Query: 734 AKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIM 793
GY+ ++ IP GA++I+++QR +G + ++LA+K + G Y+LNG + +S +E+D++
Sbjct: 692 PMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLV 751
Query: 794 YKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKES----- 848
KG +LRYSG+ A+E +++ P+ EPLT++VL+VG P+++Y++++ K+
Sbjct: 752 VKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSSH 811
Query: 849 ----------FNAIPTFS------------AWVIEEWGECSKSCELGWQRRLVECRDING 886
N++ + S WV WG CS SC G Q+R V+CR G
Sbjct: 812 PKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAG 871
Query: 887 Q---PASECAKEVKPASTRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVL 943
Q PA + A +P T+ C + PCP W+L WS CSK+CG+G+++RSLKC+ H G +L
Sbjct: 872 QRTVPACDAAH--RPVETQACGE-PCPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLL 928
Query: 944 SHESCDPLKKPKHFIDFCTMAEC 966
+ + C+ +KP+ +DFC + C
Sbjct: 929 ARDQCNLHRKPQE-LDFCVLRPC 950
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 885 bits (2287), Expect = 0.0
Identities = 452/913 (49%), Positives = 597/913 (65%), Gaps = 54/913 (5%)
Query: 24 APGSRSFGPVPTLLLLAAALLAVSDALGRPSEEDEELVVPELERAPGH-GTTRLRLHAFD 82
AP + + P+ LLLL L + A + ELVVP R PG G L L AF
Sbjct: 4 APAAPRWPPLLLLLLLLLPLARGAPARPAAGGQASELVVPT--RLPGSAGELALHLSAFG 61
Query: 83 QQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSAAALSLC 142
+ L L PD SFLAP F ++ +G SG T E L CF+SGTVNG+P S AA+SLC
Sbjct: 62 KGFVLRLAPDDSFLAPEFKIERLGG-SGRATG-GERGLRGCFFSGTVNGEPESLAAVSLC 119
Query: 143 EGVRGAFYLLGEAYFIQPLPAASE-----RLATAAPGEKPPAPLQFHLLRRNRQGDVGGT 197
G+ G+F L GE + IQP A RL P P P R + +V
Sbjct: 120 RGLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGARPLP-------RGPEWEVETG 172
Query: 198 CGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGSIRKKRFVSSH 257
G + + G + + E+E E E EGA P P G S R KRFVS
Sbjct: 173 EG----QRQERGDHQEDSEEESQEEEAEGASEPPP---------PLGATS-RTKRFVSEA 218
Query: 258 RYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQK 317
R+VET+LVAD SMA F+G+ L++++LTL SVAAR+YKHPSI+NS++L+VVK+L++ DE+
Sbjct: 219 RFVETLLVADASMAAFYGADLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKW 278
Query: 318 GPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQ-TCDTLGMADVG 376
GPEV+ N LTLRNFCNWQ++ N PSDR EHYDTAIL TRQ+ CG + CDTLG+AD+G
Sbjct: 279 GPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIG 338
Query: 377 TVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASMLSN 436
T+CDP++SCSVIED+GLQAA T AHELGHV +MPHDD+K C L G H+MA + +
Sbjct: 339 TICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVH 398
Query: 437 LDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTS--YDANRQCQFTFGE 494
L+ + PWSPCSA +T LD GHG+CL+D P + LP LPG Y ++QC+ FG
Sbjct: 399 LNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAALPLPTGLPGRMALYQLDQQCRQIFGP 458
Query: 495 DSKHCPD--AASTCSTLWCTGTSGGVLVCQTKH--FPWADGTSCGEGKWCINGKCVNKTD 550
D +HCP+ A C+ LWC T G +C TK+ PWADGT CG G C G C+ + +
Sbjct: 459 DFRHCPNTSAQDVCAQLWCH-TDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEE 517
Query: 551 RKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNL 610
+ G W WGPWG+CSRTCGGGVQ++ REC +P P+NGG+YC G+R +Y+SC+
Sbjct: 518 VERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHT 577
Query: 611 EDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYF 670
E+CP + GK+FRE+QCE +N ++ G ++W+PKYAGVSP+DRCKL C+A+G F
Sbjct: 578 EECPPD-GKSFREQQCEKYNAYNYTDM-DGNLLQWVPKYAGVSPRDRCKLFCRARGRSEF 635
Query: 671 FVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGS 730
V + KV+DGT C P++ ++CV+GQCVKAGCD ++DS +K DKCGVCGG G++C+K+SGS
Sbjct: 636 KVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGS 695
Query: 731 VTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQ 790
+T GY+DI+TIP GATNI+VKQR+ G +N+G++LA+K ADG Y+LNG+ +S +EQ
Sbjct: 696 LTPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQ 755
Query: 791 DIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTV-GNALRPKIKYTYFV------- 842
DI+ KG +L+YSGS A LER++SF PL EPLT+Q+LTV G PK+KYT+FV
Sbjct: 756 DILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFS 815
Query: 843 ---KKKKESFNAIPTF--SAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVK 897
K++ + N I + WV+ +W ECS +C GWQRR VECRD +GQ ++ C K +K
Sbjct: 816 MQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALK 875
Query: 898 PASTRPCADHPCP 910
P +PC CP
Sbjct: 876 PEDAKPCESQLCP 888
Score = 32.3 bits (72), Expect = 2.2
Identities = 15/44 (34%), Positives = 20/44 (45%), Gaps = 2/44 (4%)
Query: 892 CAKEVKPASTRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKC 935
C E + +P AD W G W CS+TCG G + +C
Sbjct: 512 CLPEEEVERPKPVADGGWAPW--GPWGECSRTCGGGVQFSHREC 553
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 803 bits (2073), Expect = 0.0
Identities = 411/837 (49%), Positives = 538/837 (64%), Gaps = 68/837 (8%)
Query: 36 LLLLAAALLAVSDALGRPSEEDEELVVPELERA---PGHGT-TRL--RLHAFDQQLDLEL 89
LLLL A L S L P +EE+V PE PG G RL RL AF + L LEL
Sbjct: 37 LLLLLLASLLPSARLASPLPREEEIVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLEL 96
Query: 90 RPDSSFLAPGFTLQNVGRK----SGSETPLPETDLAHCFYSGTVNGDPSSAAALSLCEG- 144
DS G T+Q +G+ G+E P T + +GT+NGDP S A+L G
Sbjct: 97 EQDSGVQVEGLTVQYLGQAPELLGGAE---PGT-----YLTGTINGDPESVASLHWDGGA 148
Query: 145 VRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNRQGDVGGTCGVVDDE 204
+ G G +QPL + A PG H+LRR
Sbjct: 149 LLGVLQYRGAELHLQPLEGGTPNSA-GGPGA--------HILRRK--------------- 184
Query: 205 PRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGSIRKKRFVSSHRYVETML 264
+ +G + + P +G P+ R KRF S R+VET++
Sbjct: 185 ---------------SPASGQGPMCNVKAP----LGSPSPRPR-RAKRFASLSRFVETLV 224
Query: 265 VADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSN 324
VAD MA FHG+GLK YLLT+ + AA+ +KHPSIRN VSLVV +++++ ++GP+V +
Sbjct: 225 VADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPS 284
Query: 325 AALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMADVGTVCDPSRS 384
AA TLR+FC WQ+ N P D D +H+DTAILFTRQDLCG TCDTLGMADVGTVCDP+RS
Sbjct: 285 AAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARS 344
Query: 385 CSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNG-VNQDSHMMASMLSNLDHSQPW 443
C+++EDDGLQ+AFT AHELGHVFNM HD++K C SLNG ++ H+MA +++++D +PW
Sbjct: 345 CAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPW 404
Query: 444 SPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDAA 503
SPCSA IT FLDNG+G CL+DKP+ P+ LP PG YDA+RQCQ TFG DS+HCP
Sbjct: 405 SPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLP 464
Query: 504 STCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKTDRKHFDTPFHGSWG 563
C+ LWC+G G +CQTKH PWADGT CG + C+ G+C++ + F+ P G WG
Sbjct: 465 PPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWG 524
Query: 564 MWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFRE 623
WGPWGDCSRTCGGGVQ++ R+C PVP+NGGKYCEG+R R+RSCN EDCP + TFRE
Sbjct: 525 PWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFRE 584
Query: 624 EQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPC 683
EQC A+N + ++W+P+Y GV+P+D+CKL CQA+ +GY++VL+P+VVDGTPC
Sbjct: 585 EQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPC 644
Query: 684 SPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAKPGYHDIIT 743
SPDS+SVCVQG+C+ AGCDRII SKKKFDKC VCGG+GS C K SGS + GY++++T
Sbjct: 645 SPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVT 704
Query: 744 IPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVV-LRYS 802
IP GAT+I V+Q+ G R+ +LA+K DG+Y LNG+YTL D++ G V LRYS
Sbjct: 705 IPAGATHILVRQQGNPGHRS--IYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYS 762
Query: 803 GSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFSAWV 859
G++AA E + PL +PLT+QVL GN +++Y++FV + S PT W+
Sbjct: 763 GATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVPRPTPS-TPRPTPQDWL 818
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 728 bits (1878), Expect = 0.0
Identities = 376/863 (43%), Positives = 500/863 (57%), Gaps = 38/863 (4%)
Query: 70 GHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTV 129
G G ++A ++ L+L D S GF +G T P +HCFY GTV
Sbjct: 83 GGGKVGYLVYAGGRRFLLDLERDGSVGIAGFV------PAGGGTSAPWRHRSHCFYRGTV 136
Query: 130 NGDPSSAAALSLCEGVRGAFYLLGEAYFIQPL---PAASERLATAAPGEKPPAPLQFHLL 186
+G P S A LC G+ G F + Y ++PL P A E G+ L +
Sbjct: 137 DGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVY-GDGSARILHVY-- 193
Query: 187 RRNRQG------DVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVG 240
R+G +C P A G +Q Q G
Sbjct: 194 --TREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAAL--ASQLLDQSALSPAGG 249
Query: 241 QPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRN 300
T R++R +S R VE +LVAD SMA +G GL+HYLLTL S+A RLY H SI N
Sbjct: 250 SGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIEN 309
Query: 301 SVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQD 360
+ L VVK++V+ D+ K EV+ NAA TL+NFC WQ QHN D EHYD AILFTR+D
Sbjct: 310 HIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTRED 369
Query: 361 LCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASL 420
LCG +CDTLGMADVGT+C P RSC+VIEDDGL AAFT AHE+GH+ + HDD+K C
Sbjct: 370 LCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEET 429
Query: 421 NGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGT 480
G +D +M+S+L+++D S+PWS C++ IT FLD+GHG CL+D P+ I P +LPG
Sbjct: 430 FGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQ 489
Query: 481 SYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWC 540
+YDA +QC TFG + CP C+ LWC G +VC TK P +GT CG+G+ C
Sbjct: 490 TYDATQQCNLTFGPEYSVCP-GMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRIC 548
Query: 541 INGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEG 600
+ GKCV+KT +K++ T HG+WG WG WG CSR+CGGGVQ+ R C+NP P+N G+YC G
Sbjct: 549 LQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTG 608
Query: 601 KRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKL 660
KR YRSC+L CP NGK+FR EQCEA N + + G VEW+PKYAGV P D CKL
Sbjct: 609 KRAIYRSCSLMPCPP-NGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKL 667
Query: 661 ICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGN 720
C+AKG GY+ V PKV DGT C S SVCV+G+CV+ GCD II SK ++DKCGVCGG+
Sbjct: 668 TCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGD 727
Query: 721 GSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILN 780
S+C KI G+ GY D++ IP GAT+I+V+Q + ++LA+K +G Y++N
Sbjct: 728 NSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLIN 787
Query: 781 GDYTLSTLEQDIMYKGVVLRYSGSSAALERIR--SFSPLKEPLTIQVLTVGNALRPKIKY 838
G Y +ST E I G V+ YSG S + + +S KE L +Q+L ++Y
Sbjct: 788 GKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRY 847
Query: 839 TYFV-KKKKESFNAIPTFSA-----------WVIEEWGECSKSCELGWQRRLVECRDING 886
++FV KK N++ + + WV W CS++C+ GW R V+C+D N
Sbjct: 848 SFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNR 907
Query: 887 QPASECAKEVKPASTRPCADHPC 909
+ A C +P++ + C C
Sbjct: 908 KLAKGCPLSQRPSAFKQCLLKKC 930
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif,
9 preproprotein [Homo sapiens]
Length = 1935
Score = 667 bits (1721), Expect = 0.0
Identities = 354/888 (39%), Positives = 509/888 (57%), Gaps = 49/888 (5%)
Query: 77 RLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPL---PETDLAHCFYSGTVNGDP 133
RL AF QQ L ++ F+AP FT+ +G ++T E +L HCFY G VN +
Sbjct: 101 RLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNS 160
Query: 134 SSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRN---- 189
A +SLC G+ G F YFI+PL + E+ E + H++ R
Sbjct: 161 EHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQ-------EDEEEQNKPHIIYRRSAPQ 213
Query: 190 RQGDVGG-TCGVVDDEPRPTG-----KAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPT 243
R+ G C + + R + +A E G+ A G T
Sbjct: 214 REPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKT 273
Query: 244 GTGSIRK-----KRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSI 298
++ KRF+S R+VE ++VAD M +HG L+HY+LTL S+ A +YK PSI
Sbjct: 274 DNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPSI 333
Query: 299 RNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTR 358
N +++V+V ++VIH+EQ GP ++ NA TL+NFC WQ N P H+DTA+L TR
Sbjct: 334 GNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPG---GIHHDTAVLLTR 390
Query: 359 QDLCGSQT-CDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQC 417
QD+C + CDTLG+A++GT+CDP RSCS+ ED GL AFT AHELGHVFNMPHDD +C
Sbjct: 391 QDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKC 450
Query: 418 ASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQN-PIQLPGD 476
GV H+MA L+ + WS CS IT FLD G+GECL+++P++ P LP
Sbjct: 451 KE-EGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQ 509
Query: 477 LPGTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGE 536
LPG Y+ N+QC+ FG S+ CP C LWC +G C+T+H PWADGT C
Sbjct: 510 LPGILYNVNKQCELIFGPGSQVCPYMMQ-CRRLWCNNVNGVHKGCRTQHTPWADGTECEP 568
Query: 537 GKWCINGKCVNKTDRKHFDTPF-HGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGG 595
GK C G CV K D P GSWG W P+G CSRTCGGG++ +REC+ P PKNGG
Sbjct: 569 GKHCKYGFCVPK----EMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGG 624
Query: 596 KYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASF-GSGPAVEWIPKYAGVSP 654
KYC G+R++++SCN E C + FR+EQC AH + + G P V W+PKY+G+
Sbjct: 625 KYCVGRRMKFKSCNTEPCLKQK-RDFRDEQC-AHFDGKHFNINGLLPNVRWVPKYSGILM 682
Query: 655 KDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKC 714
KDRCKL C+ G ++ L+ +V+DGTPC D+ +CVQG C +AGCD +++SK + DKC
Sbjct: 683 KDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKC 742
Query: 715 GVCGGNGSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAAD 774
GVCGG+ S+CK ++G+ + GY+ ++ IP GATNI+V+Q + G ++ ++LA+ ++
Sbjct: 743 GVCGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSK 802
Query: 775 GTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRP 834
G ++LNG++ ++ +++I V+ YSGS A+ERI S +++ L +QVL+VG P
Sbjct: 803 GEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGKLYNP 862
Query: 835 KIKYTYFVKKKKESFNAIPTFSAWVIE-EWGECSKSCELGWQRRLVECRDINGQPASE-- 891
++Y++ + + + P W W CSK C+ +R+LV R+ + S+
Sbjct: 863 DVRYSFNIPIEDK-----PQQFYWNSHGPWQACSKPCQGERKRKLVCTRESDQLTVSDQR 917
Query: 892 CAKEVKPAS-TRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSH 938
C + +P T PC +W + S CS CG GY+ + C +
Sbjct: 918 CDRLPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKY 965
Score = 96.7 bits (239), Expect = 9e-20
Identities = 41/97 (42%), Positives = 53/97 (54%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGEW 917
W WG CS +C G QRR+V C+D NG A++C + +KP R C PCPQW G W
Sbjct: 1332 WRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNW 1391
Query: 918 SSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
C+K CG G + R + C +G SC+ L KP
Sbjct: 1392 GECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKP 1428
Score = 86.7 bits (213), Expect = 1e-16
Identities = 45/119 (37%), Positives = 62/119 (52%), Gaps = 7/119 (5%)
Query: 854 TFSA----WVIEEWGECSKSCELGWQRRLVECRDINGQPASE--CAKEVKPASTRPCADH 907
T+SA W W CS +C G + R V CRD NG A E CA +P + C+
Sbjct: 1178 TYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECSVT 1237
Query: 908 PCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
PC QW+ +WSSCS TCG+G R + C+++ V+ CD P+ D C+M+ C
Sbjct: 1238 PCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQD-CSMSPC 1295
Score = 84.0 bits (206), Expect = 6e-16
Identities = 44/112 (39%), Positives = 58/112 (51%), Gaps = 5/112 (4%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPA--SECAKEVKPASTRPCADHPCPQWQLG 915
W W ECSKSC+ G QRR C + S+C + K R C++ PCPQW+ G
Sbjct: 1001 WRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQR-CSEFPCPQWKSG 1059
Query: 916 EWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAECS 967
+WS C TCGKG+K R + C + L+ CDP KP + C EC+
Sbjct: 1060 DWSECLVTCGKGHKHRQVWCQFGEDR-LNDRMCDPETKPTS-MQTCQQPECA 1109
Score = 74.7 bits (182), Expect = 4e-13
Identities = 37/105 (35%), Positives = 58/105 (55%), Gaps = 11/105 (10%)
Query: 846 KESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDI-NGQPASECAKE-------VK 897
+ES + P W+ EW ECS +C G+++RLV C +I G+ E + + +
Sbjct: 1604 RESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQ 1663
Query: 898 PASTRPCADHPCP---QWQLGEWSSCSKTCGKGYKKRSLKCLSHD 939
P S PC CP W++G W SCS +CG G +RS++CL+++
Sbjct: 1664 PPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNE 1708
Score = 74.3 bits (181), Expect = 5e-13
Identities = 35/108 (32%), Positives = 52/108 (48%), Gaps = 2/108 (1%)
Query: 850 NAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQ--PASECAKEVKPASTRPCADH 907
+A P +AW W CS SC G ++R V C +G + C KP R C
Sbjct: 1437 HACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGG 1496
Query: 908 PCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPK 955
CP+W+ G WS CS +CG+G ++R + C + C+P +P+
Sbjct: 1497 RCPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPE 1544
Score = 72.8 bits (177), Expect = 1e-12
Identities = 35/81 (43%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPA--SECAKEVKPASTRPCADHPCPQ-WQL 914
W EEW EC+K+C G + R V C D N + C +P C+ PC W
Sbjct: 1559 WRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWIT 1618
Query: 915 GEWSSCSKTCGKGYKKRSLKC 935
GEWS CS TCGKGYK+R + C
Sbjct: 1619 GEWSECSVTCGKGYKQRLVSC 1639
Score = 72.4 bits (176), Expect = 2e-12
Identities = 40/125 (32%), Positives = 57/125 (45%), Gaps = 25/125 (20%)
Query: 853 PTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPAS-----ECAKEVKPASTRPC--- 904
P ++W WG+CS +C G+Q R V+C I G S +C +P T+ C
Sbjct: 1106 PECASWQAGPWGQCSVTCGQGYQLRAVKC--IIGTYMSVVDDNDCNAATRPTDTQDCELP 1163
Query: 905 ADHPCP---------------QWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCD 949
+ HP P QW+ G W+ CS TCGKG + R + C +G V +C
Sbjct: 1164 SCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACA 1223
Query: 950 PLKKP 954
L +P
Sbjct: 1224 TLPRP 1228
Score = 70.5 bits (171), Expect = 7e-12
Identities = 36/111 (32%), Positives = 51/111 (45%), Gaps = 3/111 (2%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASE-CAKEVKPASTRPCADHPCPQWQLGE 916
W +W EC +C G + R V C+ + C E KP S + C C WQ G
Sbjct: 1056 WKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGP 1115
Query: 917 WSSCSKTCGKGYKKRSLKC-LSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
W CS TCG+GY+ R++KC + V+ C+ +P D C + C
Sbjct: 1116 WGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQD-CELPSC 1165
Score = 69.3 bits (168), Expect = 2e-11
Identities = 37/113 (32%), Positives = 55/113 (48%), Gaps = 5/113 (4%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPA--SECAKEVKPASTRPCADHPCP--QWQ 913
W W +CS SC G Q+R V C+ + A +EC +P S R C CP W+
Sbjct: 1501 WKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWR 1560
Query: 914 LGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
EW C+KTCG+G + R + C+ + + CD K+P + C++ C
Sbjct: 1561 AEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVD-RESCSLQPC 1612
Score = 50.4 bits (119), Expect = 8e-06
Identities = 32/131 (24%), Positives = 48/131 (36%), Gaps = 37/131 (28%)
Query: 846 KESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQ--PASECAKEVKPASTRP 903
KE + P W +W CS +C G R V C + + SEC ++ P + +
Sbjct: 1231 KEECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQD 1289
Query: 904 CADHPCPQ----------------------------------WQLGEWSSCSKTCGKGYK 929
C+ PCPQ W+ G W +CS TC G +
Sbjct: 1290 CSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQ 1349
Query: 930 KRSLKCLSHDG 940
+R + C +G
Sbjct: 1350 RRVVVCQDENG 1360
Score = 46.2 bits (108), Expect = 1e-04
Identities = 18/52 (34%), Positives = 27/52 (51%)
Query: 853 PTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPC 904
P + W + WG CS SC +G +R V+C QP+ C ++KP + C
Sbjct: 1676 PVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTC 1727
Score = 43.1 bits (100), Expect = 0.001
Identities = 35/140 (25%), Positives = 56/140 (40%), Gaps = 34/140 (24%)
Query: 506 CSTLWCTGTSGGVLVCQTKHFPWADGT----SCGEGKWCINGKCVNKTDRKHFDTPFHGS 561
CS+ G+ V+VCQ ++ A+ E + C +G C
Sbjct: 1340 CSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQ-------------- 1385
Query: 562 WGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTF 621
W +G WG+C++ CGGG++ + C G+R SC + D P +
Sbjct: 1386 WA-YGNWGECTKLCGGGIRTRLVVCQR---------SNGERFPDLSCEILDKPPD----- 1430
Query: 622 REEQCEAHNEFSKASFGSGP 641
EQC H A++ +GP
Sbjct: 1431 -REQCNTHACPHDAAWSTGP 1449
Score = 37.7 bits (86), Expect = 0.052
Identities = 19/48 (39%), Positives = 26/48 (54%), Gaps = 2/48 (4%)
Query: 915 GEWSSCSKTCGKGYKKRSLKCL-SHDGGVLSHESCDPLKKPKHFIDFC 961
G W +CSK C +G +KR L C D +S + CD L +P H + C
Sbjct: 885 GPWQACSKPC-QGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPC 931
Score = 35.8 bits (81), Expect = 0.20
Identities = 42/158 (26%), Positives = 53/158 (33%), Gaps = 45/158 (28%)
Query: 466 KPQNPIQLPGDLP--GTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVL---- 519
KP N + G+ G Y A +C SK C D + C T VL
Sbjct: 985 KPSNREKCSGECNTGGWRYSAWTEC-------SKSC-DGGTQRRRAICVNTRNDVLDDSK 1036
Query: 520 --------VCQTKHFP---WADG------TSCGEGK-----WCINGK-------CVNKTD 550
+ + FP W G +CG+G WC G+ C +T
Sbjct: 1037 CTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETK 1096
Query: 551 RKHFDTPFHGSWGMW--GPWGDCSRTCGGGVQYTMREC 586
T W GPWG CS TCG G Q +C
Sbjct: 1097 PTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKC 1134
Score = 32.7 bits (73), Expect = 1.7
Identities = 39/172 (22%), Positives = 56/172 (32%), Gaps = 49/172 (28%)
Query: 495 DSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWAD-GTSCGEGKWCINGKCVNKTDRKH 553
D + C A W TG PW+ SCG G N C+ K D H
Sbjct: 1430 DREQCNTHACPHDAAWSTG-------------PWSSCSVSCGRGHKQRNVYCMAK-DGSH 1475
Query: 554 FDTPF--------------HGSWGMW--GPWGDCSRTCGGGVQY-------------TMR 584
++ + G W G W CS +CG GVQ
Sbjct: 1476 LESDYCKHLAKPHGHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARET 1535
Query: 585 ECDNPVPKNGGKYCEGKR---VRYRSCNLEDCPD--NNGKTFREEQCEAHNE 631
EC+ + C+G R +R+ ++C G +R+ C N+
Sbjct: 1536 ECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNK 1587
Score = 30.8 bits (68), Expect = 6.4
Identities = 13/32 (40%), Positives = 17/32 (53%), Gaps = 1/32 (3%)
Query: 555 DTPFHGSWGMWGPWGDCSRTCGGGVQYTMREC 586
D P +W + G WG CS +CG GV +C
Sbjct: 1674 DCPVSATWRV-GNWGSCSVSCGVGVMQRSVQC 1704
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 639 bits (1648), Expect = 0.0
Identities = 351/908 (38%), Positives = 501/908 (55%), Gaps = 56/908 (6%)
Query: 74 TRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVG--RKSGSETPLPETDLAHCFYSGTVNG 131
T R A+ Q L L D+SFLA G+T ++G + E+ +DL HCFY G VN
Sbjct: 78 THYRFTAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNS 137
Query: 132 DPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNRQ 191
A +SLC G+ G F YF++P+ A G P HL+ R
Sbjct: 138 QEDYKAVVSLCGGLTGTFKGQNGEYFLEPIMKADGN--EYEDGHNKP-----HLIYRQ-- 188
Query: 192 GDVGGT-------CGVVDDEPRPTGKA----ETEDEDEGTEGEDEGAQWSPQDPALQGVG 240
D+ + C V + + + T +ED E S P
Sbjct: 189 -DLNNSFLQTLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERR 247
Query: 241 QPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRN 300
RKKR +S RY+E M+ AD + HGS L++Y+LTL S+ A +YK PSI N
Sbjct: 248 HS------RKKRLISYPRYIEIMVTADAKVVSAHGSNLQNYILTLMSIVATIYKDPSIGN 301
Query: 301 SVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQD 360
+ +VVVK+++IH E++GP + + A TL+NFC+WQ+ N D H+DTA+L TR+D
Sbjct: 302 LIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITRED 361
Query: 361 LCGS-QTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCAS 419
+C S + C+ LG++ +GT+CDP +SC + E+ GL +AFT AHELGH + HDD +C
Sbjct: 362 ICSSKEKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCKE 421
Query: 420 LNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPI-QLPGDLP 478
+ H+MA LS WS CS +T FLD G+GECL+DKP I LP +LP
Sbjct: 422 MKVTKY--HVMAPALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELP 479
Query: 479 GTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGK 538
G+ YD N+QC+ FG S+ CP + C LWCT T C T+H P ADGT CG G
Sbjct: 480 GSRYDGNKQCELAFGPGSQMCPHI-NICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGM 538
Query: 539 WCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYC 598
C +G CVNK P +G WG W P+ CSRTCGGG++ R C+ P P+NGG YC
Sbjct: 539 HCRHGLCVNKETETR---PVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYC 595
Query: 599 EGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRC 658
G+R+++RSCN + CP + FRE+QC N G V W+P+Y+G+ KDRC
Sbjct: 596 VGRRMKFRSCNTDSCPKGT-QDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRC 654
Query: 659 KLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCG 718
KL CQ G YF++L+ V DGTPC ++ +CVQGQC+ AGCD +++S K DKCGVCG
Sbjct: 655 KLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCG 714
Query: 719 GNGSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYI 778
G+ S+CK I+G S+ GY+ ++ IP GATN++++Q + G ++ S+LA+ A+G ++
Sbjct: 715 GDNSSCKTITGVFNSSHYGYNVVVKIPAGATNVDIRQYSYSGQPDD-SYLALSDAEGNFL 773
Query: 779 LNGDYTLSTLEQDIMYKG--VVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKI 836
NG++ LST +++I +G V+ YSGS+ A+ERI S + ++ L +QVL VGN P +
Sbjct: 774 FNGNFLLSTSKKEINVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDV 833
Query: 837 KYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVEC---RDINGQPASECA 893
Y++ + ++ S F+ W C+K C+ G QRR + C D + EC
Sbjct: 834 HYSFNIPLEERS----DMFTWDPYGPWEGCTKMCQ-GLQRRNITCIHKSDHSVVSDKECD 888
Query: 894 KEVKPASTRPCADHPCP-QWQLGEWSSCSKTCGKGYKKRSLKCLS---HDGGVL---SHE 946
P+ + C +W + S CS CG+GY+ + C+ H+G + H
Sbjct: 889 HLPLPSFVTQSCNTDCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHY 948
Query: 947 SCDPLKKP 954
D LK P
Sbjct: 949 CGDQLKPP 956
Score = 102 bits (253), Expect = 2e-21
Identities = 47/109 (43%), Positives = 56/109 (51%), Gaps = 1/109 (0%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGEW 917
W WG CS SC G Q R V C+D NGQ AS C KP + C PCPQW G W
Sbjct: 1308 WRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNW 1367
Query: 918 SSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
CS+TCG G K R + C +G +L +C+ + KP I C M C
Sbjct: 1368 GECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQ-CHMHAC 1415
Score = 81.3 bits (199), Expect = 4e-15
Identities = 40/114 (35%), Positives = 55/114 (48%), Gaps = 5/114 (4%)
Query: 857 AWVIEEWGECSKSCELGWQRRLVECRDINGQPASE--CAKEVKPASTRPCADHPCPQWQL 914
+W EW EC +C G ++R V C+ +N S+ C KP S PC H C WQ+
Sbjct: 1024 SWAASEWSECLVTCGKGTKQRQVWCQ-LNVDHLSDGFCNSSTKPESLSPCELHTCASWQV 1082
Query: 915 GEWSSCSKTCGKGYKKRSLKCLSH-DGGVLSHESCDPLKKPKHFIDFCTMAECS 967
G W C+ TCG GY+ R +KC++ VL C +P C + CS
Sbjct: 1083 GPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSD-RQSCVLTPCS 1135
Score = 74.3 bits (181), Expect = 5e-13
Identities = 42/117 (35%), Positives = 56/117 (47%), Gaps = 5/117 (4%)
Query: 852 IPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASE--CAKEVKPASTRPCADHPC 909
I + W W CS SC G Q R V CRD + A E CA +PA C PC
Sbjct: 1150 IKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDCFT-PC 1208
Query: 910 PQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
+WQ G+WS CS +CG G R + C+++ + CDP +P C++A C
Sbjct: 1209 GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPI-DENYCDPEVRPL-MEQECSLAAC 1263
Score = 71.2 bits (173), Expect = 4e-12
Identities = 37/119 (31%), Positives = 54/119 (45%), Gaps = 8/119 (6%)
Query: 850 NAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASE--CAKEVKPASTRPCADH 907
+A P +W E W CS SC G + R V C D + + C++ KP + + C
Sbjct: 1413 HACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSV 1472
Query: 908 PCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
CP W+ W+ CS TCG G ++R + C G + E CD +P C+ C
Sbjct: 1473 RCPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRP------CSQRRC 1525
Score = 67.0 bits (162), Expect = 8e-11
Identities = 40/116 (34%), Positives = 58/116 (50%), Gaps = 7/116 (6%)
Query: 855 FSAWVIEEWGECSKSCELGWQRRLVECRDINGQPAS--ECAKEVKPASTRPCADHPCPQW 912
F+ W EW +CS+SC G + R C + G + EC +E+ + C + CP W
Sbjct: 967 FTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNEC-QELSRVTRENCNEFSCPSW 1025
Query: 913 QLGEWSSCSKTCGKGYKKRSLKC-LSHDGGVLSHESCDPLKKPKHFIDFCTMAECS 967
EWS C TCGKG K+R + C L+ D LS C+ KP+ + C + C+
Sbjct: 1026 AASEWSECLVTCGKGTKQRQVWCQLNVDH--LSDGFCNSSTKPES-LSPCELHTCA 1078
Score = 59.3 bits (142), Expect = 2e-08
Identities = 33/131 (25%), Positives = 54/131 (41%), Gaps = 22/131 (16%)
Query: 854 TFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPA---SECAKEVKPASTRPCADHPC- 909
T ++W + WG C+ +C G+Q R V+C + +EC + +P+ + C PC
Sbjct: 1076 TCASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCS 1135
Query: 910 ------------------PQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPL 951
QW+ G W+ CS +CG+G + R + C + C L
Sbjct: 1136 FISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHL 1195
Query: 952 KKPKHFIDFCT 962
+P D T
Sbjct: 1196 PRPAEIWDCFT 1206
Score = 53.5 bits (127), Expect = 9e-07
Identities = 39/161 (24%), Positives = 56/161 (34%), Gaps = 47/161 (29%)
Query: 838 YTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASE--CAKE 895
Y + + E ++ W +W CS SC G R V C + + QP E C E
Sbjct: 1191 YCAHLPRPAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYH-QPIDENYCDPE 1249
Query: 896 VKPASTRPCADHPCP------------------------------------------QWQ 913
V+P + C+ CP QW+
Sbjct: 1250 VRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWR 1309
Query: 914 LGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
G W SCS +C G + R++ C +G S+ CD KP
Sbjct: 1310 TGPWGSCSSSCSGGLQHRAVVCQDENGQSASY--CDAASKP 1348
Score = 52.0 bits (123), Expect = 3e-06
Identities = 32/111 (28%), Positives = 54/111 (48%), Gaps = 20/111 (18%)
Query: 859 VIEEWGECSKSCELGWQRRLVECRDINGQPASECAK--EVKPASTRPCADHPCPQ----- 911
V + +C+ +C +++R+ C +I P+++ K ++P + C P Q
Sbjct: 1593 VTADSSQCANNCGFSYRQRITYCTEI---PSTKKHKLHRLRPIVYQECPVVPSSQVYQCI 1649
Query: 912 --------WQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
W++G+WS CS TCG G KR +KC++ G LS + C KP
Sbjct: 1650 NSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHG--LSSDLCLNHLKP 1698
Score = 47.4 bits (111), Expect = 7e-05
Identities = 96/504 (19%), Positives = 177/504 (35%), Gaps = 106/504 (21%)
Query: 424 NQDSHMMASMLSNLDHSQPWSPCSAYM--------ITSFLDNGHGECLMDKPQNPIQL-- 473
N++ + S+ N + PW CS+ + +NG D P +L
Sbjct: 1294 NENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQ 1353
Query: 474 --PGDLPGTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADG 531
PG P +Y +C T G G +++CQ + +
Sbjct: 1354 CGPGPCPQWNYGNWGECSQTCGG------------------GIKSRLVICQFPNGQILED 1395
Query: 532 TSCGEGKWCINGKCVNKTD---RKHFDT-PFHGSWGMWGPWGDCSRTCGGGVQYTMRECD 587
+C + VNK + H P SW PW CS +CG G +Y C
Sbjct: 1396 HNC---------EIVNKPPSVIQCHMHACPADVSWHQ-EPWTSCSASCGKGRKYREVFCI 1445
Query: 588 NPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAH--NEFSKASFGSGPAVEW 645
+ + ++ +C+ P + K R +C + N +++ S G
Sbjct: 1446 DQFQR---------KLEDTNCSQVQKPPTH-KACRSVRCPSWKANSWNECSVTCG----- 1490
Query: 646 IPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRII 705
+GV +D + C+ KG+G +VV+ ST C Q +C C +
Sbjct: 1491 ----SGVQQRD---VYCRLKGVG-------QVVE--EMCDQSTRPCSQRRCWSQDCVQHK 1534
Query: 706 DSKKKFDKCGVCGGNGSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNG 765
++ C + +++ + + + I ++ I + +N R N
Sbjct: 1535 GMERGRLNCSTSCERKDSHQRMECTDNQIR----QVNEIVYNSSTISLTSKNCRNPPCN- 1589
Query: 766 SFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQV 825
++ + A N ++ Q I Y + S L R+R P+ Q
Sbjct: 1590 -YIVVTADSSQCANNCGFSY---RQRITYCTEIP--STKKHKLHRLR-------PIVYQE 1636
Query: 826 LTVGNALRPKIKYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDIN 885
V + + + N+ + W + +W +CS +C +G +R V+C +
Sbjct: 1637 CPVVPS-----------SQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKH 1685
Query: 886 GQPASECAKEVKPASTRPCADHPC 909
G + C +KP + + C + C
Sbjct: 1686 GLSSDLCLNHLKPGAQKKCYANDC 1709
Score = 36.2 bits (82), Expect = 0.15
Identities = 46/197 (23%), Positives = 67/197 (34%), Gaps = 40/197 (20%)
Query: 442 PWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPD 501
PW PC+ GHG + D ++ +L + + + D + C
Sbjct: 1084 PWGPCTTTC-------GHGYQMRD-----VKCVNELASAVLEDTECHEASRPSDRQSCVL 1131
Query: 502 AASTCSTLWCTGTSGGVLV---CQTKHFPWAD-GTSCGEGKWCINGKCVNKTDR------ 551
+ + T VL+ Q +H W SCG G C + DR
Sbjct: 1132 TPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESY 1191
Query: 552 -KHFDTPFH--------GSWGMWGPWGDCSRTCGGGVQYTMRECDN---PVPKNGGKYC- 598
H P G W G W CS +CG G C N P+ +N YC
Sbjct: 1192 CAHLPRPAEIWDCFTPCGEWQA-GDWSPCSASCGHGKTTRQVLCMNYHQPIDEN---YCD 1247
Query: 599 -EGKRVRYRSCNLEDCP 614
E + + + C+L CP
Sbjct: 1248 PEVRPLMEQECSLAACP 1264
Score = 33.1 bits (74), Expect = 1.3
Identities = 21/70 (30%), Positives = 29/70 (41%), Gaps = 14/70 (20%)
Query: 533 SCGEGK-----WC-------INGKCVNKTDRKHFDTPFHGSWGMW--GPWGDCSRTCGGG 578
+CG+G WC +G C + T + + W GPWG C+ TCG G
Sbjct: 1036 TCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGPWGPCTTTCGHG 1095
Query: 579 VQYTMRECDN 588
Q +C N
Sbjct: 1096 YQMRDVKCVN 1105
Score = 32.7 bits (73), Expect = 1.7
Identities = 20/73 (27%), Positives = 32/73 (43%), Gaps = 3/73 (4%)
Query: 866 CSKSCELGWQRRLVECRDINGQPASECAKEVKPAS--TRPCADHPCPQWQL-GEWSSCSK 922
CS SCE + +EC D + +E S ++ C + PC + + S C+
Sbjct: 1543 CSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCAN 1602
Query: 923 TCGKGYKKRSLKC 935
CG Y++R C
Sbjct: 1603 NCGFSYRQRITYC 1615
Score = 31.6 bits (70), Expect = 3.8
Identities = 17/52 (32%), Positives = 22/52 (42%), Gaps = 2/52 (3%)
Query: 565 WGPWGDCSRTCGGGVQYTMRECDNPVPKN--GGKYCEGKRVRYRSCNLEDCP 614
+ W CSR+CGGG + C N + E RV +CN CP
Sbjct: 972 YSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCP 1023
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif,
6 preproprotein [Homo sapiens]
Length = 1117
Score = 486 bits (1251), Expect = e-137
Identities = 300/890 (33%), Positives = 443/890 (49%), Gaps = 72/890 (8%)
Query: 77 RLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETD-LAHCFYSGTVNGDPSS 135
+L A+ + L L ++ F++ FT++ G+ + P + D L +C Y+G + S+
Sbjct: 88 KLSAYGKHFHLNLTLNTDFVSKHFTVEYWGK----DGPQWKHDFLDNCHYTGYLQDQRST 143
Query: 136 A-AALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNRQGDV 194
ALS C G+ G E YFI+PL +E + P + + R
Sbjct: 144 TKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQRHLYD 203
Query: 195 GGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGSI--RKKR 252
CGV D G W D + P I R+KR
Sbjct: 204 HSHCGVSDFTR-------------------SGKPWWLNDTSTVSYSLPINNTHIHHRQKR 244
Query: 253 FVSSHRYVETMLVADQSMAEFHG-SGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILV 311
VS R+VET++VAD+ M +HG ++HY+L++ ++ A+LY+ S+ N V+++V +++V
Sbjct: 245 SVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIV 304
Query: 312 IHDEQKGPEVTSNAALTLRNFCNWQKQ-------HNPPSDRDAEHYDTAILFTRQDLCG- 363
+ ++Q E+ +A +L +FC WQK N + H+D A+L TR D+C
Sbjct: 305 LTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTY 364
Query: 364 -SQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNG 422
++ C TLG+A V +C+P RSCS+ ED GL +AFT AHE+GH F M HD G
Sbjct: 365 KNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKG 424
Query: 423 VNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKP-QNPIQLPGDLPGTS 481
++ + +MA+ ++ + WS CS ITSFLD+G G CL ++P + P PG
Sbjct: 425 -HEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQV 483
Query: 482 YDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGK--- 538
YDA+ QC+F +G S+ C C LWC S C T P A+GT C G
Sbjct: 484 YDADEQCRFQYGATSRQCK-YGEVCRELWCLSKSNR---CVTNSIPAAEGTLCQTGNIEK 539
Query: 539 -WCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKY 597
WC G CV + G WG W WG+CSRTCGGGV ++R CD+P P GGKY
Sbjct: 540 GWCYQGDCVPFGT---WPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKY 596
Query: 598 CEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDR 657
C G+R RYRSCN + CP + FRE+QC +F F G W P Y G K
Sbjct: 597 CLGERKRYRSCNTDPCP-LGSRDFREKQCA---DFDNMPF-RGKYYNWKP-YTGGGVKP- 649
Query: 658 CKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVC 717
C L C A+G ++ P V+DGT C+ DS +C+ G+C GCD I+ S + D+C VC
Sbjct: 650 CALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVC 709
Query: 718 GGNGSTCKKISGSVTSAKP--GYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADG 775
GG+GSTC I G + P GY +++ IP G+ +IEV R S+N ++A+K+
Sbjct: 710 GGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEV--REVAMSKN---YIALKSEGD 764
Query: 776 TYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPK 835
Y +NG +T+ + G Y + E + + P E L + VL L +
Sbjct: 765 DYYINGAWTID-WPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIR 823
Query: 836 IKYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASE---C 892
K+ + + N + W + W ECS +C G QR+ V C+ ++ + C
Sbjct: 824 YKFNVPITRTGSGDNEVG--FTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYC 881
Query: 893 AKEVK-PASTRPCADHPC-PQWQLGEWSSCSKTCGKGYKKRSLKCLSHDG 940
+ K P + R C PC P+W +G+W CSKTC G + R++ C+ G
Sbjct: 882 DPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIG 931
Score = 71.6 bits (174), Expect = 3e-12
Identities = 35/101 (34%), Positives = 54/101 (53%), Gaps = 5/101 (4%)
Query: 845 KKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQ---PASECAKEVKPAST 901
+KE N WV +W EC+ C G++ R+V C+ + PA++C +E KP
Sbjct: 950 EKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVR 1009
Query: 902 RPCADHPCP--QWQLGEWSSCSKTCGKGYKKRSLKCLSHDG 940
C+ CP +W G+W CS CG G + R+++CLS+ G
Sbjct: 1010 IRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTG 1050
Score = 55.1 bits (131), Expect = 3e-07
Identities = 23/63 (36%), Positives = 33/63 (52%), Gaps = 1/63 (1%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGEW 917
WV +WG+CS C LG Q R V+C GQ +S+C + V+P S + C + C +
Sbjct: 1022 WVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQC-ESKCDSTPISNT 1080
Query: 918 SSC 920
C
Sbjct: 1081 EEC 1083
Score = 38.5 bits (88), Expect = 0.031
Identities = 17/56 (30%), Positives = 24/56 (42%), Gaps = 1/56 (1%)
Query: 912 WQLGEWSSCSKTCGKGYKKRSLKCLS-HDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
W WS CS TC G +++ + C D ++ + CDP KP C C
Sbjct: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPC 899
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif,
7 preproprotein [Homo sapiens]
Length = 1686
Score = 480 bits (1235), Expect = e-135
Identities = 317/896 (35%), Positives = 447/896 (49%), Gaps = 78/896 (8%)
Query: 83 QQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPS---SAAAL 139
++L L + LAPGF + R+ G C G V DP AA+
Sbjct: 89 RELRFNLTANQHLLAPGF-VSETRRRGGLGRAHIRAHTPACHLLGEVQ-DPELEGGLAAI 146
Query: 140 SLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGE--KPPAPLQFHLLRRNRQGDVGGT 197
S C+G++G F L E YFI+PL +A R A P K AP + L + T
Sbjct: 147 SACDGLKGVFQLSNEDYFIEPLDSAPARPGHAQPHVVYKRQAPER---LAQRGDSSAPST 203
Query: 198 CGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGSIRKKRFVSSH 257
CGV + P E E E E + QW + P L+ + Q R VS
Sbjct: 204 CGV---QVYP----ELESRRERWE---QRQQW--RRPRLRRLHQ----------RSVSKE 241
Query: 258 RYVETMLVADQSMAEFHGSG-LKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQ 316
++VET++VAD M E+HG ++ Y+LT+ ++ A L+ PSI N + + +V+++++ DE+
Sbjct: 242 KWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEE 301
Query: 317 KGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCG--SQTCDTLGMAD 374
+ ++T +A TL++FC WQK N D H+DTAIL TR+DLC ++ C+TLG++
Sbjct: 302 EDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSH 361
Query: 375 VGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASML 434
V +C P RSCS+ ED GL AFT AHELGH F + HD + V + +M+ L
Sbjct: 362 VAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGN--DCEPVGKRPFIMSPQL 419
Query: 435 SNLDHSQPWSPCSAYMITSFLDNGHGECLMDKP-QNPIQLPGDLPGTSYDANRQCQFTFG 493
WS CS IT FLD G G CL D P ++ I P PG YD + QC+ +G
Sbjct: 420 LYDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYG 479
Query: 494 EDSKHCPDAASTCSTLWCT-GTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKTDRK 552
S C D + C TLWC+ GT+ C +K DGT CGE KWC++G+CV R
Sbjct: 480 AYSAFCEDMDNVCHTLWCSVGTT-----CHSKLDAAVDGTRCGENKWCLSGECVPVGFRP 534
Query: 553 HFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLED 612
G W W W CSR+CG GVQ R+C P PK G+YC G+R R+R CNL+
Sbjct: 535 E---AVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQA 591
Query: 613 CPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFV 672
CP +FR QC + A G W+P V+P C+L C+ +
Sbjct: 592 CPAGR-PSFRHVQCSHFD----AMLYKGQLHTWVPVVNDVNP---CELHCRPANEYFAEK 643
Query: 673 LQPKVVDGTPCSP--DSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGS 730
L+ VVDGTPC S +C+ G C GCD IDS D+CGVC GNGSTC +SG+
Sbjct: 644 LRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGT 703
Query: 731 VTSAKP-GYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAAD-GTYILNGDYTLSTL 788
A+ GY D+ IP GA I +++ + +FLA+++ D Y LNG +T+
Sbjct: 704 FEEAEGLGYVDVGLIPAGAREIRIQEVAEA-----ANFLALRSEDPEKYFLNGGWTIQ-W 757
Query: 789 EQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKES 848
D G Y+ E + S P KEP+ IQ+L P + Y Y + ++
Sbjct: 758 NGDYQVAGTTFTYA-RRGNWENLTSPGPTKEPVWIQLLF--QESNPGVHYEYTIHREAGG 814
Query: 849 FNAI-PTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASE--CAKEVKP-ASTRPC 904
+ + P +W W +C+ +C G QR+ V C + P E C +P R C
Sbjct: 815 HDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKC 874
Query: 905 ADHPCP-QWQLGEWSSCSKTCGK-GYKKRSLKCLSHDG----GVLSHESCDPLKKP 954
++ PCP +W GEW CS +CG G +R++ C+ G L +C+ L +P
Sbjct: 875 SEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRP 930
Score = 82.8 bits (203), Expect = 1e-15
Identities = 35/91 (38%), Positives = 52/91 (57%), Gaps = 5/91 (5%)
Query: 857 AWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGE 916
+W W ECS++C G Q+RLV C + C + ++P +TRPC HPC QW +G
Sbjct: 1523 SWYTSSWRECSEACGGGEQQRLVTCPE-----PGLCEEALRPNTTRPCNTHPCTQWVVGP 1577
Query: 917 WSSCSKTCGKGYKKRSLKCLSHDGGVLSHES 947
W CS CG G ++R +KC++ G+ +S
Sbjct: 1578 WGQCSGPCGGGVQRRLVKCVNTQTGLPEEDS 1608
Score = 66.6 bits (161), Expect = 1e-10
Identities = 36/104 (34%), Positives = 47/104 (45%), Gaps = 6/104 (5%)
Query: 856 SAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLG 915
+ W W ECS +C LG R V C + +CA +P R C PC W G
Sbjct: 1413 AGWQAGNWSECSTTCGLGAVWRPVRCSSGRDE---DCAPAGRPQPARRCHLRPCATWHSG 1469
Query: 916 EWSSCSKTCGKGYKKRSLKCL-SHDGGVLSHESCD--PLKKPKH 956
WS CS++CG G R ++C+ + D L C P K P H
Sbjct: 1470 NWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAH 1513
Score = 63.9 bits (154), Expect = 7e-10
Identities = 44/123 (35%), Positives = 62/123 (50%), Gaps = 15/123 (12%)
Query: 853 PTFSAWVIEEWGECSKSCELGW-QRRLVECR---DINGQPASE---CAKEVKPASTRPCA 905
P + W EW CS SC G RR V C ++ Q A E C +P + PC
Sbjct: 878 PCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCN 937
Query: 906 DH-PCPQ-WQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTM 963
H PCP W +G WS CS TCG+G ++R++ C ++D GV CD ++P + C++
Sbjct: 938 RHVPCPATWAVGNWSQCSVTCGEGTQRRNVLC-TNDTGV----PCDEAQQPASEVT-CSL 991
Query: 964 AEC 966
C
Sbjct: 992 PLC 994
Score = 60.5 bits (145), Expect = 8e-09
Identities = 29/84 (34%), Positives = 39/84 (46%), Gaps = 4/84 (4%)
Query: 856 SAWVIEEWGECSKSCELGWQRRLVEC---RDINGQPASECAK-EVKPASTRPCADHPCPQ 911
+ W W +CS+SC G R V+C RD+ C KP + RPC PC
Sbjct: 1464 ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLS 1523
Query: 912 WQLGEWSSCSKTCGKGYKKRSLKC 935
W W CS+ CG G ++R + C
Sbjct: 1524 WYTSSWRECSEACGGGEQQRLVTC 1547
Score = 49.7 bits (117), Expect = 1e-05
Identities = 24/56 (42%), Positives = 31/56 (55%), Gaps = 4/56 (7%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDIN-GQP---ASECAKEVKPASTRPCADHPC 909
WV+ WG+CS C G QRRLV+C + G P + +C E P S+RPC C
Sbjct: 1573 WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
Score = 43.9 bits (102), Expect = 7e-04
Identities = 23/64 (35%), Positives = 33/64 (51%), Gaps = 4/64 (6%)
Query: 852 IPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQ 911
+P + W + W +CS +C G QRR V C + G P C + +PAS C+ P +
Sbjct: 940 VPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVP---CDEAQQPASEVTCS-LPLCR 995
Query: 912 WQLG 915
W LG
Sbjct: 996 WPLG 999
Score = 42.7 bits (99), Expect = 0.002
Identities = 22/53 (41%), Positives = 26/53 (49%), Gaps = 5/53 (9%)
Query: 566 GPWGDCSRTCGGGVQYTMRECDNP---VPKNGGKYC--EGKRVRYRSCNLEDC 613
GPWG CS CGGGVQ + +C N +P+ C E R C EDC
Sbjct: 1576 GPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
Score = 33.1 bits (74), Expect = 1.3
Identities = 22/75 (29%), Positives = 28/75 (37%), Gaps = 19/75 (25%)
Query: 533 SCGEGKWCINGKCVNKTDRKHFDTPFHGSWGMWGP------------------WGDCSRT 574
SCG G + +CV+ D + PFH G P W +CS
Sbjct: 1477 SCGGGSSVRDVQCVDTRDLRPL-RPFHCQPGPAKPPAHRPCGAQPCLSWYTSSWRECSEA 1535
Query: 575 CGGGVQYTMRECDNP 589
CGGG Q + C P
Sbjct: 1536 CGGGEQQRLVTCPEP 1550
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 473 bits (1216), Expect = e-133
Identities = 292/840 (34%), Positives = 425/840 (50%), Gaps = 75/840 (8%)
Query: 122 HCFYSGTVNGDPSSA-AALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAP 180
HC Y+G + G S++ A+S C G+ G E Y I+PL + + +P E P
Sbjct: 121 HCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPK--GSRSPEESGPHV 178
Query: 181 LQFHLLRRNRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQW---SPQDPALQ 237
+ R+ D CGV D++P +G W + + P +
Sbjct: 179 VYKRSSLRHPHLDTA--CGVRDEKPW------------------KGRPWWLRTLKPPPAR 218
Query: 238 GVGQPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGS-GLKHYLLTLFSVAARLYKHP 296
+G T G KR VS RYVET++VAD+ M +HG ++ Y+L + ++ A+L++
Sbjct: 219 PLGNETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDS 278
Query: 297 SIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQ-------HNPPSDRDAEH 349
S+ ++V+++V +++++ ++Q E+T +A +L +FC WQK N + +
Sbjct: 279 SLGSTVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVAN 338
Query: 350 YDTAILFTRQDLC--GSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVF 407
+DTA+L TR D+C ++ C TLG+A VG +C+ RSCSV ED GL AFT AHE+GH F
Sbjct: 339 HDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTF 398
Query: 408 NMPHDDAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKP 467
M HD G + +MA+ ++ + WS CS ITSFLD+G G CL ++P
Sbjct: 399 GMNHDGVGNSCGARG-QDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRP 457
Query: 468 -QNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHF 526
+ P PG +YDA+ QC+F G S+ C CS LWC S C T
Sbjct: 458 PRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCK-YGEVCSELWCLSKSNR---CITNSI 513
Query: 527 PWADGTSCG----EGKWCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYT 582
P A+GT C + WC CV R G+WG W PWGDCSRTCGGGV +
Sbjct: 514 PAAEGTLCQTHTIDKGWCYKRVCVPFGSRPE---GVDGAWGPWTPWGDCSRTCGGGVSSS 570
Query: 583 MRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPA 642
R CD+P P GGKYC G+R R+RSCN +DCP + + FRE QC +EF F G
Sbjct: 571 SRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGS-QDFREVQC---SEFDSIPF-RGKF 625
Query: 643 VEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCD 702
+W Y G K C L C A+G ++ VVDGTPC PD+ +CV G+C GCD
Sbjct: 626 YKW-KTYRGGGVK-ACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCD 683
Query: 703 RIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAKP--GYHDIITIPTGATNIEVKQRNQRG 760
R++ S + DKC VCGG+GS C+ I G + A P GY D++ IP G+ +I ++ N
Sbjct: 684 RVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNL-- 741
Query: 761 SRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEP 820
+ S LA+K + +L G + + G + ++ + + P+
Sbjct: 742 ---SLSHLALKGDQESLLLEG-LPGTPQPHRLPLAGTTFQLRQGPDQVQSLEALGPINAS 797
Query: 821 LTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVE 880
L + VL P ++Y + ++S +P +S W W +CS C G Q + VE
Sbjct: 798 LIVMVL--ARTELPALRYRFNAPIARDS---LPPYS-WHYAPWTKCSAQCAGGSQVQAVE 851
Query: 881 CR---DINGQPASECAKEVK-PASTRPCADHPC-PQWQLGEWSSCSKTCGKGYKKRSLKC 935
CR D + C+ K P R C PC P W +G WS CS++C G + RS+ C
Sbjct: 852 CRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVC 911
Score = 80.5 bits (197), Expect = 7e-15
Identities = 38/102 (37%), Positives = 55/102 (53%), Gaps = 6/102 (5%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQ---PASECAKEVKPASTRPCADHPCP--QW 912
W +W EC+ SC G + R+V C+ + + P + C+ KP +T C CP +W
Sbjct: 948 WAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARW 1007
Query: 913 QLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
GEW CS CG G ++RS++C SH G SHE + L+ P
Sbjct: 1008 VAGEWGECSAQCGVGQRQRSVRCTSHTGQA-SHECTEALRPP 1048
Score = 62.4 bits (150), Expect = 2e-09
Identities = 38/131 (29%), Positives = 57/131 (43%), Gaps = 10/131 (7%)
Query: 844 KKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECR------DINGQPASECAKEVK 897
K++ + N P WV+ W CS+SC+ G + R V C+ + S C + +
Sbjct: 874 KRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSAC-PQPR 932
Query: 898 PASTRPCADHPC-PQWQLGEWSSCSKTCGKGYKKRSLKCLSHD-GGVLSHESCDPLKKPK 955
P C C P+W +WS C+ +CG G + R + C S D L C P KP
Sbjct: 933 PPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPP 992
Query: 956 HFIDFCTMAEC 966
+ C + C
Sbjct: 993 ATMR-CNLRRC 1002
Score = 54.3 bits (129), Expect = 5e-07
Identities = 23/56 (41%), Positives = 32/56 (57%), Gaps = 3/56 (5%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPC---ADHPCP 910
WV EWGECS C +G ++R V C GQ + EC + ++P +T+ C D P P
Sbjct: 1007 WVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSPTP 1062
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 468 bits (1205), Expect = e-132
Identities = 303/900 (33%), Positives = 451/900 (50%), Gaps = 81/900 (9%)
Query: 77 RLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSG--SETPLPETDLAHCFYSGTV--NGD 132
R+ ++ L L + FL+ + ++ ++ G S + + C SGTV G
Sbjct: 94 RISHEEKDLFFNLTVNQGFLSNSYIME---KRYGNLSHVKMMASSAPLCHLSGTVLQQGT 150
Query: 133 PSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNRQG 192
AALS C G+ G F L +FI+P+ ++ G P H++ R ++
Sbjct: 151 RVGTAALSACHGLTGFFQLPHGDFFIEPV----KKHPLVEGGYHP------HIVYRRQK- 199
Query: 193 DVGGTCGVVDDEPRPT-GKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGSIRKK 251
V + PT G ++ + + E E +W + + + +
Sbjct: 200 --------VPETKEPTCGLKDSVNISQKQELWRE--KWERHNLPSRSLS----------R 239
Query: 252 RFVSSHRYVETMLVADQSMAEFHGS-GLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKIL 310
R +S R+VET++VAD M E+HGS ++ Y+LT+ ++ L+ +PSI N++ +VVV+++
Sbjct: 240 RSISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLI 299
Query: 311 VIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCG--SQTCD 368
++ +E++G ++ +A TL +FC WQK NP SD + H+D A+L TR+D+C ++ C+
Sbjct: 300 LLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCE 359
Query: 369 TLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSH 428
TLG++ + +C P RSC++ ED GL AFT AHELGH F + HD + V + +
Sbjct: 360 TLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKEN--DCEPVGRHPY 417
Query: 429 MMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNP-IQLPGDLPGTSYDANRQ 487
+M+ L WS CS IT FLD G G CL D P+ ++ PG YD + Q
Sbjct: 418 IMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQ 477
Query: 488 CQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVN 547
CQ +G ++ C + + C TLWC+ C++K ADGT CGE KWC+ GKC+
Sbjct: 478 CQLQYGPNATFCQEVENVCQTLWCSVKG----FCRSKLDAAADGTQCGEKKWCMAGKCIT 533
Query: 548 KTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRS 607
+K P G WG W PW CSRTCG GVQ R C+NP PK GGKYC G+R RYR
Sbjct: 534 -VGKKPESIP--GGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRL 590
Query: 608 CNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGI 667
CN+ C + TFR+ QC +EF + W P + +P C+L C+
Sbjct: 591 CNVHPC-RSEAPTFRQMQC---SEFDTVPY-KNELYHWFPIF---NPAHPCELYCRPIDG 642
Query: 668 GYFFVLQPKVVDGTPC--SPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCK 725
+ + V+DGTPC +S +VC+ G C GCD IDS D+CGVC G+GS+C+
Sbjct: 643 QFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQ 702
Query: 726 KISGSVTSAK-PGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAAD-GTYILNGDY 783
+ + GY DI IP GA +I V + G+FLAI++ D Y LNG +
Sbjct: 703 TVRKMFKQKEGSGYVDIGLIPKGARDIRVME-----IEGAGNFLAIRSEDPEKYYLNGGF 757
Query: 784 TLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVK 843
+ + G V +Y LE++ + P E + IQ+L P IKY Y ++
Sbjct: 758 IIQ-WNGNYKLAGTVFQYD-RKGDLEKLMATGPTNESVWIQLLF--QVTNPGIKYEYTIQ 813
Query: 844 KKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVEC--RDINGQPASECAKEVKP-AS 900
K + W W ECS +C G +R+ C + A+ C E +P
Sbjct: 814 KDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGR 873
Query: 901 TRPCADHPC-PQWQLGEWSSCSKTCG-KGYKKRSLKCLS---HDGGVLSHESCDPLKKPK 955
+ C + C P+W GEW +CS TCG G KKR++ C+ D L C L KPK
Sbjct: 874 QKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPK 933
Score = 79.7 bits (195), Expect = 1e-14
Identities = 37/104 (35%), Positives = 52/104 (50%), Gaps = 9/104 (8%)
Query: 857 AWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGE 916
AW +E W +CS+SC G Q R V C P C +P ST C +H C W G
Sbjct: 1426 AWQVEPWSQCSRSCGGGVQERGVFC------PGGLCDWTKRPTSTMSCNEHLCCHWATGN 1479
Query: 917 WSSCSKTCGKGYKKRSLKCLSHDGGVLSHES---CDPLKKPKHF 957
W CS +CG G++KR+++C+ +G + CD +P F
Sbjct: 1480 WDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEF 1523
Score = 74.3 bits (181), Expect = 5e-13
Identities = 31/79 (39%), Positives = 45/79 (56%), Gaps = 3/79 (3%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGEW 917
W++ W ECS +C LG R VEC + Q S+CA +P + C PC W++G W
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVEC---STQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNW 1373
Query: 918 SSCSKTCGKGYKKRSLKCL 936
S CS+ C G+K R ++C+
Sbjct: 1374 SKCSRNCSGGFKIREIQCV 1392
Score = 63.2 bits (152), Expect = 1e-09
Identities = 32/104 (30%), Positives = 51/104 (49%), Gaps = 13/104 (12%)
Query: 856 SAWVIEEWGECSKSCELGWQRRLVEC---RDINGQPASECA--KEVKPASTRPCADHPCP 910
+ W + W +CS++C G++ R ++C RD C + P + C PC
Sbjct: 1366 AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCE 1425
Query: 911 QWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
WQ+ WS CS++CG G ++R + C GG+ CD K+P
Sbjct: 1426 AWQVEPWSQCSRSCGGGVQERGVFC---PGGL-----CDWTKRP 1461
Score = 37.0 bits (84), Expect = 0.089
Identities = 20/55 (36%), Positives = 24/55 (43%), Gaps = 3/55 (5%)
Query: 856 SAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCP 910
S W + W ECS SC G + R V C + +P C KP S C CP
Sbjct: 946 SDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEP---CDVTRKPNSRALCGLQQCP 997
Score = 36.6 bits (83), Expect = 0.12
Identities = 17/48 (35%), Positives = 24/48 (50%), Gaps = 1/48 (2%)
Query: 907 HPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSH-DGGVLSHESCDPLKK 953
H W +G WS CS TCG G R ++C + D + + DP K+
Sbjct: 1312 HGSAHWIVGNWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKR 1359
Score = 35.0 bits (79), Expect = 0.34
Identities = 16/57 (28%), Positives = 23/57 (40%), Gaps = 5/57 (8%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASE-----CAKEVKPASTRPCADHPC 909
W W CS SC G+Q+R V+C G + C + +P + C C
Sbjct: 1475 WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
Score = 33.9 bits (76), Expect = 0.76
Identities = 28/102 (27%), Positives = 37/102 (36%), Gaps = 32/102 (31%)
Query: 500 PDAASTCSTLWCTGTSGGVLVCQTKHFPWAD-GTSCGEGKWCINGKCVNKTDRKHFDTPF 558
PD A C C G G W+ +C G +CV+ D ++ PF
Sbjct: 1354 PDPAKRCHLRPCAGWKVG---------NWSKCSRNCSGGFKIREIQCVDSRDHRNL-RPF 1403
Query: 559 H--------------------GSWGMWGPWGDCSRTCGGGVQ 580
H +W + PW CSR+CGGGVQ
Sbjct: 1404 HCQFLAGIPPPLSMSCNPEPCEAWQV-EPWSQCSRSCGGGVQ 1444
Score = 33.9 bits (76), Expect = 0.76
Identities = 30/105 (28%), Positives = 39/105 (37%), Gaps = 22/105 (20%)
Query: 527 PWAD-GTSCG-----EGKWCINGKC---VNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGG 577
PW+ SCG G +C G C T + W G W CS +CGG
Sbjct: 1431 PWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSCNEHLCCHWAT-GNWDLCSTSCGG 1489
Query: 578 GVQYTMRECDNPVPKNGGK-------YCEGK--RVRYRSCNLEDC 613
G Q +C VP G K C+ K ++ CN + C
Sbjct: 1490 GFQKRTVQC---VPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
Score = 33.5 bits (75), Expect = 0.99
Identities = 18/53 (33%), Positives = 25/53 (47%), Gaps = 6/53 (11%)
Query: 566 GPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRV--RYRSCNLEDCPDN 616
G W +CS +CGGGV+ C KN + C+ R C L+ CP +
Sbjct: 951 GNWSECSVSCGGGVRIRSVTC----AKNHDEPCDVTRKPNSRALCGLQQCPSS 999
Score = 32.0 bits (71), Expect = 2.9
Identities = 30/97 (30%), Positives = 38/97 (39%), Gaps = 15/97 (15%)
Query: 543 GKCVNKTDRKHFDTPFHGSWGMW--GPWGDCSRTCGGGVQYTMRECDNPVPKNGG---KY 597
G +N ++ K T HGS W G W +CS TCG G + EC + + +
Sbjct: 1297 GFLLNASNYKQL-TNGHGS-AHWIVGNWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRP 1354
Query: 598 CEGKRVRYRSC------NLEDCPDN--NGKTFREEQC 626
KR R C N C N G RE QC
Sbjct: 1355 DPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQC 1391
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 463 bits (1192), Expect = e-130
Identities = 310/983 (31%), Positives = 446/983 (45%), Gaps = 127/983 (12%)
Query: 77 RLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSA 136
R AF Q+L LEL+P S+ L+ F +Q +G+ SET PE CFY G + D SS+
Sbjct: 100 RFSAFGQELHLELKP-SAILSSHFIVQVLGKDGASETQKPEVQ--QCFYQGFIRNDSSSS 156
Query: 137 AALSLCEGVRGAFYLLGEAYFIQPLPA--ASERLATAAPGEKPPAPLQFHLLRRNRQGDV 194
A+S C G+ G + I PLP A E ++ G P L +R + +
Sbjct: 157 VAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHV-----LYKRTAEEKI 211
Query: 195 GGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQ------PTGTGSI 248
G G + + E E Q G + PT +
Sbjct: 212 QRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYL 271
Query: 249 RKKRFVSSHR------------YVETMLVADQSMAEFHGSG-LKHYLLTLFSVAARLYKH 295
R + SS R VET++VAD+ M E HG G + Y+LT+ ++ + L+K
Sbjct: 272 RFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKD 331
Query: 296 PSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAIL 355
+I + +++VVV ++++ E G + +A +L +FC WQ + ++ + +D AIL
Sbjct: 332 GTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQ---SALIGKNGKRHDHAIL 388
Query: 356 FTRQDLCG--SQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHD- 412
T D+C ++ CDTLG A + +C RSC++ ED GL AFT AHE GH F M HD
Sbjct: 389 LTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDG 448
Query: 413 DAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQ 472
+ C G ++M+ L+ + WS CS + FL CL+D+P+ Q
Sbjct: 449 EGNPCRKAEG-----NIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQ 503
Query: 473 L--PGDLPGTSYDANRQCQFTFGEDSKHCP--DAASTCSTLWCTGTSGGVLVCQTKHFPW 528
P LPG YDA+ QC++ FG +K C C +LWC C+TK P
Sbjct: 504 YKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHR---CETKFMPA 560
Query: 529 ADGTSCGEGKWCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDN 588
A+GT CG WC G+CV + P HG W W W +CSRTCGGGV++ R C+N
Sbjct: 561 AEGTVCGLSMWCRQGQCVKFGELG--PRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNN 618
Query: 589 PVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPK 648
P P+ GG +C G Y+ CN+ C +N+ FR +QC +N SK G +W P
Sbjct: 619 PKPQYGGLFCPGSSRIYQLCNINPCNENS-LDFRAQQCAEYN--SKPF--RGWFYQWKP- 672
Query: 649 YAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSK 708
Y V +DRCKL C+A+ +FF + KV DGTPCSP+ VC+ G C GCD + SK
Sbjct: 673 YTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSK 732
Query: 709 KKFDKCGVCGGNGSTCKKISGSVTSAKPG--YHDIITIPTGATNIEVKQRNQRGSRNNGS 766
D CGVC G+ STCK G + Y+ ++ IP GA +IE+++ + S
Sbjct: 733 AVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQV-----SSS 787
Query: 767 FLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVL 826
+LA+++ Y L G +++ + + G Y S ER+ + P E L ++L
Sbjct: 788 YLAVRSLSQKYYLTGGWSIDW-PGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEIL 846
Query: 827 TVG---------------NALRPKIK---YTYFVKKKKESF------------------- 849
G N P K YT+ + + + S
Sbjct: 847 MQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNT 906
Query: 850 --------------------NAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPA 889
NA + W+ EW CSK+C G Q R ++C
Sbjct: 907 QVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQK 966
Query: 890 SECAKEV-----KPASTRPCADHPCP-QWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVL 943
E P + C H CP QW LG WS CSKTCG+G +KR L C L
Sbjct: 967 EEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETL 1026
Query: 944 SHESCDPLKKPKHFIDFCTMAEC 966
C L +P+ + C + C
Sbjct: 1027 PESQCTSLPRPE-LQEGCVLGRC 1048
Score = 65.9 bits (159), Expect = 2e-10
Identities = 35/108 (32%), Positives = 51/108 (47%), Gaps = 11/108 (10%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQ--PASECAKEVKPASTRPCADHPCP----- 910
W + W +CSK+C G ++R + C+ + P S+C +P C CP
Sbjct: 995 WSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRL 1054
Query: 911 QWQLGEWSSCSKTCGKGYKKRSLKC--LSHDGGVLS--HESCDPLKKP 954
QW WS CS TCG G +KR +KC G +++ C +KKP
Sbjct: 1055 QWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKP 1102
Score = 53.9 bits (128), Expect = 7e-07
Identities = 30/96 (31%), Positives = 41/96 (42%), Gaps = 17/96 (17%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQ------PASECAKEVKP-------ASTRPC 904
WV W ECS +C LG ++R ++C + Q P C KP + R C
Sbjct: 1056 WVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRAC 1115
Query: 905 ADHPCPQ----WQLGEWSSCSKTCGKGYKKRSLKCL 936
HP W W C+ TCG G + RS+ C+
Sbjct: 1116 PAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV 1151
Score = 41.6 bits (96), Expect = 0.004
Identities = 22/65 (33%), Positives = 30/65 (46%), Gaps = 1/65 (1%)
Query: 856 SAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLG 915
+ W W +C+ +C G Q R V C G+P+S C KP R C + CP +
Sbjct: 1125 AGWYSLPWQQCTVTCGGGVQTRSVHCVQ-QGRPSSSCLLHQKPPVLRACNTNFCPAPEKR 1183
Query: 916 EWSSC 920
E SC
Sbjct: 1184 EDPSC 1188
Score = 35.4 bits (80), Expect = 0.26
Identities = 17/48 (35%), Positives = 20/48 (41%)
Query: 567 PWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCP 614
PW C+ TCGGGVQ C + K R+CN CP
Sbjct: 1131 PWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCP 1178
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1
motif, 16 preproprotein [Homo sapiens]
Length = 1224
Score = 459 bits (1180), Expect = e-129
Identities = 304/890 (34%), Positives = 442/890 (49%), Gaps = 64/890 (7%)
Query: 76 LRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSET--PLPETDLAHCFYSGTVNGDP 133
LRL ++LR SS +APGF +Q +G K+G+++ LP D CFY G++
Sbjct: 99 LRLKGSRHDFHMDLRTSSSLVAPGFIVQTLG-KTGTKSVQTLPPEDF--CFYQGSLRSHR 155
Query: 134 SSAAALSLCEGVRGAFYLLGEAYFIQPLPA-ASERLATAAPGEKPPAPLQFHLLRRNRQG 192
+S+ ALS C+G+ G YF++PLP+ S +L AA G P L + G
Sbjct: 156 NSSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPG 215
Query: 193 --DVGGTCGVVDDEPRPTGKAETE---DEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGS 247
+V T + +P ++ + + G + ++ PQ P P S
Sbjct: 216 ASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRK--KYMPQPPKEDLFILPDEYKS 273
Query: 248 I--RKKRFVSSHRY----VETMLVADQSMAEFHG-SGLKHYLLTLFSVAARLYKHPSIRN 300
K+ + SHR VET++V D+ M + HG + Y+LT+ ++ + L+K +I
Sbjct: 274 CLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGG 333
Query: 301 SVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQD 360
++++ +V ++++ DEQ G ++ +A TL +FC WQ + +D +D AIL T D
Sbjct: 334 NINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQ---SGLMGKDGTRHDHAILLTGLD 390
Query: 361 LCG--SQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHD-DAKQC 417
+C ++ CDTLG A + +C RSC++ ED GL AFT AHE GH F M HD + C
Sbjct: 391 ICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMC 450
Query: 418 ASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMD--KPQNPIQLPG 475
G ++M+ L+ + WSPCS + FL CL D KP + P
Sbjct: 451 KKSEG-----NIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPE 505
Query: 476 DLPGTSYDANRQCQFTFGEDSKHC--PDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTS 533
LPG YDAN QC++ FGE +K C C LWC C+TK P A+GT
Sbjct: 506 KLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRK---CETKFMPAAEGTI 562
Query: 534 CGEGKWCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKN 593
CG WC G+CV D P HG W W W CSRTCGGGV + R C NP P +
Sbjct: 563 CGHDMWCRGGQCVKYGDEG--PKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSH 620
Query: 594 GGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVS 653
GGK+CEG + CN + CP + FR QC HN + G +W P Y V
Sbjct: 621 GGKFCEGSTRTLKLCNSQKCP-RDSVDFRAAQCAEHN----SRRFRGRHYKWKP-YTQVE 674
Query: 654 PKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDK 713
+D CKL C A+G +FF L KV DGTPCS DS +VC+ G C + GCD ++ S D
Sbjct: 675 DQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDV 734
Query: 714 CGVCGGNGSTCKKISGSVTS--AKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIK 771
CGVC GN S C G T Y+ ++TIP+GA +I + + N + S+++++
Sbjct: 735 CGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNV-----STSYISVR 789
Query: 772 AADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNA 831
A Y LNG +T+ + + G Y S E + + P E L +++L G
Sbjct: 790 NALRRYYLNGHWTVDWPGR-YKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGR- 847
Query: 832 LRPKIKYTYFVKK--KKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVEC-RDINGQ- 887
P + + Y + + ++ A P+++ W I ECS SC G C RD+ Q
Sbjct: 848 -NPGVAWEYSMPRLGTEKQPPAQPSYT-WAIVR-SECSVSCGGGQMTVREGCYRDLKFQV 904
Query: 888 PASECAKEVKPAS-TRPCADHPC-PQWQLGEWSSCSKTCGKGYKKRSLKC 935
S C + +P + PC C P W +G WS+CS+TCG G + R ++C
Sbjct: 905 NMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQC 954
Score = 72.0 bits (175), Expect = 3e-12
Identities = 40/113 (35%), Positives = 51/113 (45%), Gaps = 15/113 (13%)
Query: 857 AWVIEEWGECSKSCELGWQRRLVECRDINGQ------PASECAKEVKPASTRPCADHPCP 910
AW W ECS +C GW++R V C+ N P + C E KP C C
Sbjct: 989 AWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCH 1048
Query: 911 -----QWQLGEWSSCSKTCGKGYKKRSLKC----LSHDGGVLSHESCDPLKKP 954
QW + WS CS TC +G +KR LKC +S L+ + C L KP
Sbjct: 1049 KPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKP 1101
Score = 63.9 bits (154), Expect = 7e-10
Identities = 39/132 (29%), Positives = 63/132 (47%), Gaps = 26/132 (19%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRD--INGQ----PASECAKEVKPAST--RPCADHPC 909
W++ W +CS +CE G Q+R ++C + ++G+ + +C+ KP+ R CA PC
Sbjct: 1055 WLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPC 1114
Query: 910 PQ-------------WQLGEWSSCSKTCGKGYKKRSLKCLSHD---GGVLSHESCDPLKK 953
P+ W WS C+ +CG G + RS++CL+ G L H+ P
Sbjct: 1115 PRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQK--PSAS 1172
Query: 954 PKHFIDFCTMAE 965
FC +AE
Sbjct: 1173 LACNTHFCPIAE 1184
Score = 48.9 bits (115), Expect = 2e-05
Identities = 22/58 (37%), Positives = 31/58 (53%), Gaps = 1/58 (1%)
Query: 853 PTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCP 910
P+ +W W +C+ SC G Q R V+C G+PAS C KP+++ C H CP
Sbjct: 1125 PSRGSWFASPWSQCTASCGGGVQTRSVQCL-AGGRPASGCLLHQKPSASLACNTHFCP 1181
Score = 37.7 bits (86), Expect = 0.052
Identities = 20/58 (34%), Positives = 24/58 (41%), Gaps = 1/58 (1%)
Query: 557 PFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCP 614
P GSW PW C+ +CGGGVQ +C G K +CN CP
Sbjct: 1125 PSRGSW-FASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCP 1181
Score = 37.0 bits (84), Expect = 0.089
Identities = 23/62 (37%), Positives = 27/62 (43%), Gaps = 12/62 (19%)
Query: 561 SWGMWGPWGDCSRTCGGGVQYTMREC-------DNPVPKNGGKYCEGKRVRYR-SCNLED 612
SW + G W CSRTCGGG Q +C PVP C R +CN +
Sbjct: 930 SWSV-GNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVP---ASLCPQPAPSSRQACNSQS 985
Query: 613 CP 614
CP
Sbjct: 986 CP 987
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1
motif, 2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 402 bits (1032), Expect = e-111
Identities = 290/892 (32%), Positives = 426/892 (47%), Gaps = 92/892 (10%)
Query: 81 FDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNG-DPSSAAAL 139
F + L L LRP++ +APG T++ G K T E L C Y G V G +S+ AL
Sbjct: 116 FGRDLHLRLRPNARLVAPGATMEWQGEKG---TTRVEPLLGSCLYVGDVAGLAEASSVAL 172
Query: 140 SLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNRQGDVGGTCG 199
S C+G+ G + E +FI+PL E+ A E+ + H++ R
Sbjct: 173 SNCDGLAGLIRMEEEEFFIEPL----EKGLAAQEAEQG----RVHVVYR----------- 213
Query: 200 VVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVG---QPTGTGSIRKKRFVSS 256
+ T G + D GA D + +G + + R +R +
Sbjct: 214 ----------RPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRRRARRHAAD 263
Query: 257 HRY-VETMLVADQSMAEFHGSG-LKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVI-H 313
Y +E +L D S+ +FHG ++ YLLTL ++ +Y S+ +++V+V+I+++ +
Sbjct: 264 DDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSY 323
Query: 314 DEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMA 373
+ N + +L N C W P E++D AI TRQD S G A
Sbjct: 324 GKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPS---GMQGYA 380
Query: 374 DVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHD-DAKQCASLNGVNQDSHMMAS 432
V +C P RSC++ +DG +AF AHE GHV M HD +C + +MA
Sbjct: 381 PVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGS---IMAP 437
Query: 433 MLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKP--QNPIQLPGDLPGTSYDANRQCQF 490
++ H WS CS ++ +L + +CL+D P + LP LPG Y N QC+F
Sbjct: 438 LVQAAFHRFHWSRCSQQELSRYLHSY--DCLLDDPFAHDWPALP-QLPGLHYSMNEQCRF 494
Query: 491 TFGEDSKHCPDAAS--TCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVNK 548
FG C + C LWC+ C+TK P DGT C GK C G C+
Sbjct: 495 DFGLGYMMCTAFRTFDPCKQLWCSHPDNPYF-CKTKKGPPLDGTMCAPGKHCFKGHCIWL 553
Query: 549 T-DRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRS 607
T D D GSWG W P+G CSRTCG GV++ R+CDNP P NGG+ C G ++
Sbjct: 554 TPDILKRD----GSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQL 609
Query: 608 CNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAV-EWIPKYAGVSPKDRCKLICQAKG 666
C+ +DCPD+ FREEQC + + F G A W+P + K+RC L C+++
Sbjct: 610 CSRQDCPDSLA-DFREEQCRQWDLY----FEHGDAQHHWLP-HEHRDAKERCHLYCESRE 663
Query: 667 IGYFFVLQPKVVDGTPCS-PDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCK 725
G ++ V DGT CS D+ S+CV+G C K GCD +I S K+ DKCGVCGG+ S CK
Sbjct: 664 TGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCK 723
Query: 726 KISGSVTSA--KPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAAD-GTYILNGD 782
+ G+ T + K GY + IP GA ++ +++ + LA+K + G +ILN +
Sbjct: 724 VVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDA-----TSHHLAVKNLETGKFILNEE 778
Query: 783 YTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFV 842
+ + + GV Y E +++ PL +T+ V+ VG+ R + Y Y +
Sbjct: 779 NDVDASSKTFIAMGVEWEYRDEDGR-ETLQTMGPLHGTITVLVIPVGDT-RVSLTYKYMI 836
Query: 843 KKKK---ESFNAIPTFSA---WVIEEWGECSKSCELGWQRRLVECR---DINGQPASECA 893
+ + N + S W +++W CSK C G Q CR D CA
Sbjct: 837 HEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCA 896
Query: 894 KEVKP-ASTRPCADHPC--PQWQLGEWSSCSKTCGK-GYKKRSLKCLS--HD 939
KP A R C C P W GEW CS+TCG+ G + RS++C+ HD
Sbjct: 897 ALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHD 948
Score = 61.2 bits (147), Expect = 4e-09
Identities = 33/90 (36%), Positives = 44/90 (48%), Gaps = 9/90 (10%)
Query: 858 WVIEEWGECSKSC-ELGWQRRLVEC------RDINGQPASECAKEVKPASTRPCADHPCP 910
WV EW CS++C G Q R V C A C + +P S R C+ CP
Sbjct: 918 WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHC-NDARPESRRACSRELCP 976
Query: 911 -QWQLGEWSSCSKTCGKGYKKRSLKCLSHD 939
+W+ G WS CS TCG G ++R + C + D
Sbjct: 977 GRWRAGPWSQCSVTCGNGTQERPVLCRTAD 1006
Score = 37.0 bits (84), Expect = 0.089
Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 2/54 (3%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQ 911
W W +CS +C G Q R V CR + +E +P + R C PCP+
Sbjct: 979 WRAGPWSQCSVTCGNGTQERPVLCR--TADDSFGICQEERPETARTCRLGPCPR 1030
Score = 36.6 bits (83), Expect = 0.12
Identities = 22/57 (38%), Positives = 25/57 (43%), Gaps = 5/57 (8%)
Query: 563 GMW--GPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVR-YRSCNLEDCPDN 616
G W GPW CS TCG G Q C G C+ +R R+C L CP N
Sbjct: 977 GRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFG--ICQEERPETARTCRLGPCPRN 1031
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
motif, 17 preproprotein [Homo sapiens]
Length = 1095
Score = 400 bits (1027), Expect = e-111
Identities = 287/914 (31%), Positives = 409/914 (44%), Gaps = 133/914 (14%)
Query: 63 PELERA-PGHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVG--RKSGSETPLPETD 119
P RA PG L L AF + L L+LR D FL+ GF ++ G R+ G L
Sbjct: 69 PAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGRPAEL---- 124
Query: 120 LAHCFYSGTVNGDPSSAAALSLCE---GVRGAFYLLGEAYFIQPLPAASERLATAAPGEK 176
CFYSG V G P S +LS C G+ G L E IQPL +
Sbjct: 125 ---CFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLN-----------NSQ 170
Query: 177 PPAPLQFHLLRRNRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPAL 236
P + HL+RR P P+ +A+ ++ E + W
Sbjct: 171 GPFSGREHLIRRKWSLT-----------PSPSAEAQRPEQLCKVLTEKKKPTW------- 212
Query: 237 QGVGQPTGTGSIRKKRF-VSSHRYVETMLVADQSMAEFHGS-GLKHYLLTLFSVAARLYK 294
G+P+ R+ ++S VET++VAD M ++HG+ + ++LT+ ++ +++
Sbjct: 213 ---GRPSRDWRERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQ 269
Query: 295 HPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHN-----------PPS 343
H S+ +++ V K++++ + + +L +FC+WQ + P
Sbjct: 270 HQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGG 329
Query: 344 DRDAEHYDTAILFTRQDLC--GSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAH 401
D D A+ TR D C + CDT+G+A +G VC R C + ED+GL AFT AH
Sbjct: 330 KDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAH 389
Query: 402 ELGHVFNMPHDDA-KQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHG 460
ELGH M HDD CA + + + S+L WS CS + +FL +
Sbjct: 390 ELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLS----WSSCSRDDLENFLKSKVS 445
Query: 461 ECLM---DKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDAAST-CSTLWCTGTSG 516
CL+ + Q+ ++LP LPG Y AN QCQ FG ++ C + C+ LWC
Sbjct: 446 TCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVE-- 503
Query: 517 GVLVCQTKHFPWADGTSCGEGKWCINGKCVNKTD-RKHFDTPFHGSWGMWGPWGDCSRTC 575
G C+TK P DGT CG KWC G+CV+KT +H D G W WG W CSRTC
Sbjct: 504 GDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVD----GDWSPWGAWSMCSRTC 559
Query: 576 GGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKA 635
G G ++ R+CDNP P GG +C G V + C CP +FR++QC+AH+ S
Sbjct: 560 GTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGL-PSFRDQQCQAHDRLSPK 618
Query: 636 SFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQ 695
G AV V C+L C G ++ +V+DGTPC P T +CV G+
Sbjct: 619 KKGLLTAV--------VVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGK 670
Query: 696 CVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQ 755
C K GCD II S K D+CGVC G+G TC + G + A
Sbjct: 671 CQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHA--------------------- 709
Query: 756 RNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFS 815
RG+ S G +N D+ + L + G +RY E+I +
Sbjct: 710 ---RGTALKDS--------GKGSINSDWKIE-LPGEFQIAGTTVRYV-RRGLWEKISAKG 756
Query: 816 PLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIP------TFSAWVIEEWGECSKS 869
P K PL + VL + I Y Y V + + N + W W CS
Sbjct: 757 PTKLPLHLMVLLFHDQ-DYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQ 815
Query: 870 CELGWQRRLVECRDINGQPA-----SECAKEVKPA-STRPCADHPCP-QWQLGEWSSCSK 922
C G +R +V C I + S+C + +P R C HPC +W G WS CS
Sbjct: 816 CGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSA 875
Query: 923 TCGKGYKKRSLKCL 936
TC KG++ R + C+
Sbjct: 876 TCEKGFQHREVTCV 889
Score = 76.3 bits (186), Expect = 1e-13
Identities = 37/100 (37%), Positives = 52/100 (52%), Gaps = 6/100 (6%)
Query: 856 SAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHP-CPQWQL 914
S W EW +CS SC G +R V C + G+ C +P + C D+ C +W+
Sbjct: 923 SIWEASEWSQCSASCGKGVWKRTVACTNSQGK----CDASTRPRAEEACEDYSGCYEWKT 978
Query: 915 GEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
G+WS+CS TCGKG + R ++C+ G E C L KP
Sbjct: 979 GDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSE-CPALSKP 1017
Score = 49.7 bits (117), Expect = 1e-05
Identities = 55/198 (27%), Positives = 72/198 (36%), Gaps = 60/198 (30%)
Query: 442 PWSPCSAYMITSF----------LDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFT 491
PWSPCSA F L NG P+ PG P A + C+
Sbjct: 869 PWSPCSATCEKGFQHREVTCVYQLQNG-----THVATRPLYCPGPRPA----AVQSCE-- 917
Query: 492 FGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWAD-GTSCGEGKW-----CIN--G 543
G+D C ++W + W+ SCG+G W C N G
Sbjct: 918 -GQD----------CLSIW-------------EASEWSQCSASCGKGVWKRTVACTNSQG 953
Query: 544 KCVNKTDRKHFDT--PFHGSWGMW--GPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCE 599
KC T + + + G + W G W CS TCG G+Q + +C + V G C
Sbjct: 954 KCDASTRPRAEEACEDYSGCYE-WKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECP 1012
Query: 600 --GKRVRYRSCNLEDCPD 615
K YR C E C D
Sbjct: 1013 ALSKPAPYRQCYQEVCND 1030
Score = 44.3 bits (103), Expect = 6e-04
Identities = 20/53 (37%), Positives = 26/53 (49%), Gaps = 1/53 (1%)
Query: 858 WVIEEWGECSKSCELGWQRRLVEC-RDINGQPASECAKEVKPASTRPCADHPC 909
W +W CS +C G Q R+V+C + G+ SEC KPA R C C
Sbjct: 976 WKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif,
3 proprotein [Homo sapiens]
Length = 1205
Score = 393 bits (1010), Expect = e-109
Identities = 277/907 (30%), Positives = 422/907 (46%), Gaps = 108/907 (11%)
Query: 80 AFDQQLDLELRPDSSFLAPGFTLQ---------NV-----GRKSGSET---PLPETDLAH 122
AF + L L+P++ +APG ++ N+ + GS T E +
Sbjct: 86 AFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKTEPLQTN 145
Query: 123 CFYSGTVNGDPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQ 182
C Y G + P ++ A+S C+G+ G E YFI+PL + +
Sbjct: 146 CAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKG---------R 196
Query: 183 FHLLRRNRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQP 242
H++ + V+ P K E + +D G + L
Sbjct: 197 IHVVYKR---------SAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNE---- 243
Query: 243 TGTGSIRKKRFVSSHRY-VETMLVADQSMAEFHGSG-LKHYLLTLFSVAARLYKHPSIRN 300
++R++R + Y +E +L D S+ FHG +++YLLTL ++ +Y S+
Sbjct: 244 ----TMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGV 299
Query: 301 SVSLVVVKILVIHDEQKGPEVT-SNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQ 359
+++V+V+++++ + + N + +L N C W Q +EH+D AI TRQ
Sbjct: 300 HINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQ 359
Query: 360 DL--CGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHD-DAKQ 416
D G Q G A V +C P RSC++ +DG +AF AHE GHV M HD +
Sbjct: 360 DFGPAGMQ-----GYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNR 414
Query: 417 CASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKP--QNPIQLP 474
C + +MA ++ H WS CS + ++ + +CL+D P + +LP
Sbjct: 415 CGDETAMGS---VMAPLVQAAFHRYHWSRCSGQELKRYIHSY--DCLLDDPFDHDWPKLP 469
Query: 475 GDLPGTSYDANRQCQFTFGEDSKHCPDAAS--TCSTLWCTGTSGGVLVCQTKHFPWADGT 532
+LPG +Y + QC+F FG K C + C LWC+ C+TK P DGT
Sbjct: 470 -ELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYF-CKTKKGPPLDGT 527
Query: 533 SCGEGKWCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPK 592
C GKWC G C+ K + G+WG W +G CSRTCG GV++ R+C+NP+P
Sbjct: 528 ECAAGKWCYKGHCMWKNANQQKQD---GNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPI 584
Query: 593 NGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGV 652
NGG+ C G Y+ CN E+C + + FR +QC+ N + W+P Y
Sbjct: 585 NGGQDCPGVNFEYQLCNTEEC-QKHFEDFRAQQCQQRNSHFEY---QNTKHHWLP-YEHP 639
Query: 653 SPKDRCKLICQAKGIGYFFVLQPKVVDGTPCS-PDSTSVCVQGQCVKAGCDRIIDSKKKF 711
PK RC L CQ+K G ++ V DGT CS D S+CV+G+CVK GCD+ I S K
Sbjct: 640 DPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVE 699
Query: 712 DKCGVCGGNGSTCKKISGSVTSA--KPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLA 769
DKCGVCGG+ S C+ + G+ T K GY + IP GA ++ +++ + LA
Sbjct: 700 DKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQE-----DEASPHILA 754
Query: 770 IK-AADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTV 828
IK A G YILNG + + GV Y+ +E + + PL +P+ + ++
Sbjct: 755 IKNQATGHYILNGKGE-EAKSRTFIDLGVEWDYN-IEDDIESLHTDGPLHDPVIVLIIPQ 812
Query: 829 GNALRPKIKYTYFVKKKKESFNAIPTFSA------------WVIEEWGECSKSCELGWQR 876
N R + Y Y + + +++PT ++ W ++ W +CSK C G+Q
Sbjct: 813 ENDTRSSLTYKYIIHE-----DSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQY 867
Query: 877 RLVECR---DINGQPASECAKEVKPAS-TRPCADHPC--PQWQLGEWSSCSKTCG-KGYK 929
CR D S C KP R C C P W EW C+KTCG GY+
Sbjct: 868 TKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQ 927
Query: 930 KRSLKCL 936
R+++CL
Sbjct: 928 LRTVRCL 934
Score = 72.0 bits (175), Expect = 3e-12
Identities = 38/93 (40%), Positives = 48/93 (51%), Gaps = 7/93 (7%)
Query: 854 TFSAWVIEEWGECSKSC-ELGWQRRLVECRD-----INGQPASECAKEVKPASTRPCADH 907
T WV EEW C+K+C G+Q R V C N S+ +P S RPC
Sbjct: 905 THPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRV 964
Query: 908 PCP-QWQLGEWSSCSKTCGKGYKKRSLKCLSHD 939
PCP QW+ G WS CS TCG+G + R + C + D
Sbjct: 965 PCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGD 997
Score = 42.4 bits (98), Expect = 0.002
Identities = 35/124 (28%), Positives = 51/124 (41%), Gaps = 20/124 (16%)
Query: 494 EDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCG-EGKWCINGKCVNKTDRK 552
E+ +HC TC G+SG L P DGT+ K+C+ + ++
Sbjct: 912 EEWEHC---TKTC------GSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCN 962
Query: 553 HFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVR-YRSCNLE 611
P W GPW +CS TCG G + C G +C+G++ R+C L
Sbjct: 963 RVPCP--AQWKT-GPWSECSVTCGEGTEVRQVLC------RAGDHCDGEKPESVRACQLP 1013
Query: 612 DCPD 615
C D
Sbjct: 1014 PCND 1017
Score = 38.9 bits (89), Expect = 0.023
Identities = 20/60 (33%), Positives = 26/60 (43%), Gaps = 1/60 (1%)
Query: 850 NAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPC 909
N +P + W W ECS +C G + R V CR E + V+ PC D PC
Sbjct: 962 NRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCR-AGDHCDGEKPESVRACQLPPCNDEPC 1020
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 377 bits (969), Expect = e-104
Identities = 267/897 (29%), Positives = 406/897 (45%), Gaps = 92/897 (10%)
Query: 70 GHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQ-NVGRKSGSETPLPETDLAHCFYSGT 128
G + + F ++L L LRP+ + PG +++ + PL + C Y+G
Sbjct: 102 GRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQ----ECVYTGG 157
Query: 129 VNGDPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRR 188
V G P +A A+S C+G+ G +FI+PL + + + H++ R
Sbjct: 158 VTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQEKEASG---------RTHVVYR 208
Query: 189 NRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQG-VGQPTGTGS 247
V + P G E G P L G VG G
Sbjct: 209 RE--------AVQQEWAEPDGDLHNEAFGLGDL------------PNLLGLVGDQLGDTE 248
Query: 248 IRKKRFVSSHRY-VETMLVADQSMAEFHGSG-LKHYLLTLFSVAARLYKHPSIRNSVSLV 305
RK+R Y +E +LV D S+ FHG +++Y+LTL ++ +Y S+ +++
Sbjct: 249 -RKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIA 307
Query: 306 VVKILVIHDEQKGPEVT-SNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGS 364
+V+++++ Q + N + +L C W AEH+D + TRQD S
Sbjct: 308 LVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPS 367
Query: 365 QTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHD-DAKQCASLNGV 423
G A V +C P RSC++ +DG +AF AHE GHV M HD CA +
Sbjct: 368 ------GYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSL 421
Query: 424 NQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPI-QLPGDLPGTSY 482
+MA ++ H WS CS ++ +L + +CL+D P +P P +LPG +Y
Sbjct: 422 GS---VMAPLVQAAFHRFHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINY 476
Query: 483 DANRQCQFTFGEDSKHCPDAAS--TCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWC 540
+ QC+F FG + C + C LWC+ C+TK P DGT C GKWC
Sbjct: 477 SMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYF-CKTKKGPPLDGTECAPGKWC 535
Query: 541 INGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEG 600
G C+ K+ + + G W W +G CSR+CGGGV+ R C+NP P GG+ C G
Sbjct: 536 FKGHCIWKSPEQTYGQD--GGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLG 593
Query: 601 KRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKL 660
Y+ CN E+CP + FR +QC N + W+P Y +C+L
Sbjct: 594 PMFEYQVCNSEECP-GTYEDFRAQQCAKRNSY---YVHQNAKHSWVP-YEPDDDAQKCEL 648
Query: 661 ICQAKGIGYFFVLQPKVVDGTPCS-PDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGG 719
ICQ+ G + V DGT CS D SVC +G+CV GCD+ + S K DKCGVCGG
Sbjct: 649 ICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGG 708
Query: 720 NGSTCKKISGSV--TSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTY 777
+ S C+ + G++ S + G ++ IP GA +I+++ + R + G++
Sbjct: 709 DNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHR----IVVKNQVTGSF 764
Query: 778 ILNGDYTLSTLEQDIMYKGVVLRYSGS-SAALERIRSFSPLKEPLTIQVL--TVGNALRP 834
ILN +T + + L + + A E +++ PL E + I L T G R
Sbjct: 765 ILNPKGKEATSR---TFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGP-RS 820
Query: 835 KIKYTYFVKK--------KKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVEC---RD 883
+ Y Y + + + T+ W ++ W CSK+C G Q C RD
Sbjct: 821 SLAYKYVIHEDLLPLIGSNNVLLEEMDTYE-WALKSWAPCSKACGGGIQFTKYGCRRRRD 879
Query: 884 INGQPASECAKEVKPAS-TRPCADHPC--PQWQLGEWSSCSKTCGK-GYKKRSLKCL 936
+ C + +P R C HPC P W EW +CS++CGK G + R ++CL
Sbjct: 880 HHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCL 936
Score = 80.9 bits (198), Expect = 5e-15
Identities = 42/86 (48%), Positives = 54/86 (62%), Gaps = 9/86 (10%)
Query: 858 WVIEEWGECSKSC-ELGWQRRLVECRD--ING----QPASECAKEVKPASTRPCADHPCP 910
WV EEWG CS+SC +LG Q R ++C NG PA CA + +P + RPC PCP
Sbjct: 911 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGD-RPEARRPCLRVPCP 969
Query: 911 -QWQLGEWSSCSKTCGKGYKKRSLKC 935
QW+LG WS CS TCG+G ++R + C
Sbjct: 970 AQWRLGAWSQCSATCGEGIQQRQVVC 995
Score = 37.4 bits (85), Expect = 0.068
Identities = 28/100 (28%), Positives = 39/100 (39%), Gaps = 15/100 (15%)
Query: 557 PFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRV-RYRSCNLEDCPD 615
P W + G W CS TCG G+Q C G +CEG R + C+L C
Sbjct: 967 PCPAQWRL-GAWSQCSATCGEGIQQRQVVCRTNANSLG--HCEGDRPDTVQVCSLPACGG 1023
Query: 616 NN-GKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSP 654
N+ T R + E P +W+P+ + P
Sbjct: 1024 NHQNSTVRADVWEL----------GTPEGQWVPQSEPLHP 1053
Score = 33.9 bits (76), Expect = 0.76
Identities = 17/58 (29%), Positives = 28/58 (48%), Gaps = 2/58 (3%)
Query: 852 IPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPC 909
+P + W + W +CS +C G Q+R V CR N C + +P + + C+ C
Sbjct: 966 VPCPAQWRLGAWSQCSATCGEGIQQRQVVCR-TNANSLGHCEGD-RPDTVQVCSLPAC 1021
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1
motif, 14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 377 bits (968), Expect = e-104
Identities = 267/897 (29%), Positives = 406/897 (45%), Gaps = 89/897 (9%)
Query: 70 GHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQ-NVGRKSGSETPLPETDLAHCFYSGT 128
G + + F ++L L LRP+ + PG +++ + PL + C Y+G
Sbjct: 102 GRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQ----ECVYTGG 157
Query: 129 VNGDPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRR 188
V G P +A A+S C+G+ G +FI+PL + + + H++ R
Sbjct: 158 VTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQEKEASG---------RTHVVYR 208
Query: 189 NRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQG-VGQPTGTGS 247
V + P G E G P L G VG G
Sbjct: 209 RE--------AVQQEWAEPDGDLHNEAFGLGDL------------PNLLGLVGDQLGDTE 248
Query: 248 IRKKRFVSSHRY-VETMLVADQSMAEFHGSG-LKHYLLTLFSVAARLYKHPSIRNSVSLV 305
RK+R Y +E +LV D S+ FHG +++Y+LTL ++ +Y S+ +++
Sbjct: 249 -RKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIA 307
Query: 306 VVKILVIHDEQKGPEVT-SNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGS 364
+V+++++ Q + N + +L C W AEH+D + TRQD S
Sbjct: 308 LVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPS 367
Query: 365 QTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHD-DAKQCASLNGV 423
G A V +C P RSC++ +DG +AF AHE GHV M HD CA +
Sbjct: 368 ---GMQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSL 424
Query: 424 NQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPI-QLPGDLPGTSY 482
+MA ++ H WS CS ++ +L + +CL+D P +P P +LPG +Y
Sbjct: 425 GS---VMAPLVQAAFHRFHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINY 479
Query: 483 DANRQCQFTFGEDSKHCPDAAS--TCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWC 540
+ QC+F FG + C + C LWC+ C+TK P DGT C GKWC
Sbjct: 480 SMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYF-CKTKKGPPLDGTECAPGKWC 538
Query: 541 INGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEG 600
G C+ K+ + + G W W +G CSR+CGGGV+ R C+NP P GG+ C G
Sbjct: 539 FKGHCIWKSPEQTYGQD--GGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLG 596
Query: 601 KRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKL 660
Y+ CN E+CP + FR +QC N + W+P Y +C+L
Sbjct: 597 PMFEYQVCNSEECP-GTYEDFRAQQCAKRNSY---YVHQNAKHSWVP-YEPDDDAQKCEL 651
Query: 661 ICQAKGIGYFFVLQPKVVDGTPCS-PDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGG 719
ICQ+ G + V DGT CS D SVC +G+CV GCD+ + S K DKCGVCGG
Sbjct: 652 ICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGG 711
Query: 720 NGSTCKKISGSV--TSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTY 777
+ S C+ + G++ S + G ++ IP GA +I+++ + R + G++
Sbjct: 712 DNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHR----IVVKNQVTGSF 767
Query: 778 ILNGDYTLSTLEQDIMYKGVVLRYSGS-SAALERIRSFSPLKEPLTIQVL--TVGNALRP 834
ILN +T + + L + + A E +++ PL E + I L T G R
Sbjct: 768 ILNPKGKEATSR---TFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGP-RS 823
Query: 835 KIKYTYFVKK--------KKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVEC---RD 883
+ Y Y + + + T+ W ++ W CSK+C G Q C RD
Sbjct: 824 SLAYKYVIHEDLLPLIGSNNVLLEEMDTYE-WALKSWAPCSKACGGGIQFTKYGCRRRRD 882
Query: 884 INGQPASECAKEVKPAS-TRPCADHPC--PQWQLGEWSSCSKTCGK-GYKKRSLKCL 936
+ C + +P R C HPC P W EW +CS++CGK G + R ++CL
Sbjct: 883 HHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCL 939
Score = 80.9 bits (198), Expect = 5e-15
Identities = 42/86 (48%), Positives = 54/86 (62%), Gaps = 9/86 (10%)
Query: 858 WVIEEWGECSKSC-ELGWQRRLVECRD--ING----QPASECAKEVKPASTRPCADHPCP 910
WV EEWG CS+SC +LG Q R ++C NG PA CA + +P + RPC PCP
Sbjct: 914 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGD-RPEARRPCLRVPCP 972
Query: 911 -QWQLGEWSSCSKTCGKGYKKRSLKC 935
QW+LG WS CS TCG+G ++R + C
Sbjct: 973 AQWRLGAWSQCSATCGEGIQQRQVVC 998
Score = 37.4 bits (85), Expect = 0.068
Identities = 28/100 (28%), Positives = 39/100 (39%), Gaps = 15/100 (15%)
Query: 557 PFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRV-RYRSCNLEDCPD 615
P W + G W CS TCG G+Q C G +CEG R + C+L C
Sbjct: 970 PCPAQWRL-GAWSQCSATCGEGIQQRQVVCRTNANSLG--HCEGDRPDTVQVCSLPACGG 1026
Query: 616 NN-GKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSP 654
N+ T R + E P +W+P+ + P
Sbjct: 1027 NHQNSTVRADVWEL----------GTPEGQWVPQSEPLHP 1056
Score = 33.9 bits (76), Expect = 0.76
Identities = 17/58 (29%), Positives = 28/58 (48%), Gaps = 2/58 (3%)
Query: 852 IPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPC 909
+P + W + W +CS +C G Q+R V CR N C + +P + + C+ C
Sbjct: 969 VPCPAQWRLGAWSQCSATCGEGIQQRQVVCR-TNANSLGHCEGD-RPDTVQVCSLPAC 1024
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 369 bits (946), Expect = e-101
Identities = 271/922 (29%), Positives = 407/922 (44%), Gaps = 121/922 (13%)
Query: 63 PELERAPGHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQN--------VGRKSGSETP 114
P P LR+ AF + L L LR D FLAP F ++ G S + P
Sbjct: 154 PAQHAEPDGDEVLLRIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPP 213
Query: 115 LPETDLAHCFYSGTVNGDPSSAAALSLCEGVRGAFYLLGEAY-FIQPLPAASERLATAAP 173
P A CFY+G V P S A+ S C G F L E + FI+PL ++ +A
Sbjct: 214 APPD--AGCFYTGAVLRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPL---NDTMAITGH 268
Query: 174 GEKPPAPLQFHLLRRNRQGDV-------GGTCGVVDDEPRPTGKAETEDEDEGTEGEDEG 226
P + + +R+ + V CG++ D+ RP + E G
Sbjct: 269 ------PHRVYRQKRSMEEKVTEKSALHSHYCGIISDKGRPRSRKIAES--------GRG 314
Query: 227 AQWSPQDPALQGVGQPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGS-GLKHYLLTL 285
++S + P +ET++VAD +M +HG+ + ++LT+
Sbjct: 315 KRYSYKLP---------------------QEYNIETVVVADPAMVSYHGADAARRFILTI 353
Query: 286 FSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSD- 344
++ L++H S+ V+L V+K++++H+ + + L +FC WQ + +
Sbjct: 354 LNMVFNLFQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEEFGKKND 413
Query: 345 ----------RDAEHYDTAILFTRQDLC--GSQTCDTLGMADVGTVCDPSRSCSVIEDDG 392
D D AIL TR+D C + CDT+G+A + +C R C + ED+G
Sbjct: 414 IHLEMSTNWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNG 473
Query: 393 LQAAFTTAHELGHVFNMPHD-DAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMI 451
L AFT AHE+GH + HD D CA + + L ++ WS CS +
Sbjct: 474 LNLAFTIAHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVS----WSRCSKEDL 529
Query: 452 TSFLDNGHGECLMD-KPQ--NPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDAAST-CS 507
FL + CL+ PQ N + +P LPG +Y A+ QCQ FG + C + C+
Sbjct: 530 ERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFCQEMQHVICT 589
Query: 508 TLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKTDRKHFDTPFH--GSWGMW 565
LWC G C+TK P DGT C GKWC G+C ++T P H G W +W
Sbjct: 590 GLWCKVE--GEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTS-----APEHLAGEWSLW 642
Query: 566 GPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQ 625
P CSRTC G+ R+C P + + C G R +YR C CP FR+ Q
Sbjct: 643 SP---CSRTCSAGISSRERKC--PGLDSEARDCNGPRKQYRICENPPCPAGL-PGFRDWQ 696
Query: 626 CEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSP 685
C+A +S + ++W A + + C L C G +L KV+DGT C
Sbjct: 697 CQA---YSVRTSSPKHILQW---QAVLDEEKPCALFCSPVGKEQPILLSEKVMDGTSCGY 750
Query: 686 DSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAK-PGYHDIITI 744
+C G+C K GCD ++ S + D CGVC GNG +CK I G + GY +++ I
Sbjct: 751 QGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNHTRGAGYVEVLVI 810
Query: 745 PTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGS 804
P GA I+V + + S+LA++ A G +N D+ + G + Y
Sbjct: 811 PAGARRIKVVE-----EKPAHSYLALRDA-GKQSINSDWKIEH-SGAFNLAGTTVHYV-R 862
Query: 805 SAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKK----KKESFNAIPTFSAWVI 860
E+I + P PL + VL + + Y Y + + +S A W
Sbjct: 863 RGLWEKISAKGPTTAPLHLLVLLFQDQ-NYGLHYEYTIPSDPLPENQSSKAPEPLFMWTH 921
Query: 861 EEWGECSKSCELGWQRRLVECRDINGQPAS-----ECAKEVKP-ASTRPCADHPC-PQWQ 913
W +C +C G ++ V C I + S +C KP R C + PC +W
Sbjct: 922 TSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWM 981
Query: 914 LGEWSSCSKTCGKGYKKRSLKC 935
+ EW+ CS+TCGKG + R + C
Sbjct: 982 MTEWTPCSRTCGKGMQSRQVAC 1003
Score = 70.1 bits (170), Expect = 1e-11
Identities = 36/113 (31%), Positives = 54/113 (47%), Gaps = 7/113 (6%)
Query: 856 SAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHP-CPQWQL 914
+ W W ECS C G + R V C + P +C +P C D+ C W++
Sbjct: 1038 TVWEAGVWSECSVKCGKGIRHRTVRCTN----PRKKCVLSTRPREAEDCEDYSKCYVWRM 1093
Query: 915 GEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAECS 967
G+WS CS TCGKG + R ++C+ G +E C +KP + C + C+
Sbjct: 1094 GDWSKCSITCGKGMQSRVIQCMHKITGRHGNE-CFSSEKPAAYRP-CHLQPCN 1144
Score = 43.5 bits (101), Expect = 0.001
Identities = 35/121 (28%), Positives = 49/121 (40%), Gaps = 26/121 (21%)
Query: 506 CSTLWCTGTSGGVLVCQTKHFPWAD-GTSCGEG-----KWCING--KCVNKT-DRKHFDT 556
C T+W G W++ CG+G C N KCV T R+ D
Sbjct: 1036 CMTVWEAGV-------------WSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAEDC 1082
Query: 557 PFHGSWGMW--GPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYC--EGKRVRYRSCNLED 612
+ +W G W CS TCG G+Q + +C + + G C K YR C+L+
Sbjct: 1083 EDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQP 1142
Query: 613 C 613
C
Sbjct: 1143 C 1143
Score = 41.6 bits (96), Expect = 0.004
Identities = 21/72 (29%), Positives = 31/72 (43%), Gaps = 3/72 (4%)
Query: 898 PASTRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKC---LSHDGGVLSHESCDPLKKP 954
P + A P W W C TCG G +K ++ C +S + ++ +E C L KP
Sbjct: 905 PENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKP 964
Query: 955 KHFIDFCTMAEC 966
+ I C C
Sbjct: 965 EPQIRKCNEQPC 976
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 327 bits (838), Expect = 3e-89
Identities = 218/734 (29%), Positives = 324/734 (44%), Gaps = 66/734 (8%)
Query: 249 RKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVK 308
R++R ++E ++ + + H + Y+LT ++ A L + PS+ + +VK
Sbjct: 71 RQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVK 130
Query: 309 ILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDL-CGSQTC 367
++++ + + P +T+N +L + C W + NP D D H D + TR DL
Sbjct: 131 MVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNR 190
Query: 368 DTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDS 427
G+ +G C P+ SC + ED G T AHE+GH F + HD A +G
Sbjct: 191 QVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPG----SGCGPSG 246
Query: 428 HMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQ----NPIQLPGDLPGTSYD 483
H+MAS + WSPCS + S L G C+ D P+ + P PG Y
Sbjct: 247 HVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLYYS 306
Query: 484 ANRQCQFTFGEDSKHCPDAAS---TCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWC 540
AN QC+ FG + C A C L C C P DGT CG KWC
Sbjct: 307 ANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWC 366
Query: 541 INGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEG 600
G+C + + HG W WGP CSR+CGGGV R+C+NP P GG+ C G
Sbjct: 367 SKGRCRSLVELTPI-AAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVG 425
Query: 601 KRVRYRSCNLEDCPDNNGKTFREEQC-EAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCK 659
++ CN + C + F +QC + ++S G W C+
Sbjct: 426 ADLQAEMCNTQAC-EKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCR 484
Query: 660 LICQAKGIGYFFVLQPKVVDGTPCSPD------STSVCVQGQCVKAGCDRIIDSKKKFDK 713
+C+A G + +DGT C P + S+CV G C GCD +DS++ +D+
Sbjct: 485 HMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDR 544
Query: 714 CGVCGGNGSTCKKISGSVTSAKP-GYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKA 772
C VCGG+ STC GS T+ + Y +T+ T++ + R + LA++
Sbjct: 545 CQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANH-----RPLFTHLAVRI 599
Query: 773 ADGTYILNGDYTLS------TLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVL 826
G Y++ G ++S +L +D + V LE IR + PL+E IQV
Sbjct: 600 G-GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVY 658
Query: 827 -----TVGNALRPKIKYTYFVKKKKESFNAIPTFSAWVIEEW----GECSKSCELGWQRR 877
GN RP I +TYF K ++ AWV W G CS SC G +
Sbjct: 659 RRYGEEYGNLTRPDITFTYFQPKPRQ---------AWV---WAAVRGPCSVSCGAGLRWV 706
Query: 878 LVECRDINGQPASECAKEVK-------PASTRPCADHPC-PQWQLGEWSSCSKTCGKGYK 929
C D Q E + V+ PA C PC P W +G++ CS +CG G +
Sbjct: 707 NYSCLD---QARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLR 763
Query: 930 KRSLKCLSHDGGVL 943
+R ++C+ G +L
Sbjct: 764 ERPVRCVEAQGSLL 777
Score = 62.8 bits (151), Expect = 2e-09
Identities = 38/116 (32%), Positives = 55/116 (47%), Gaps = 7/116 (6%)
Query: 846 KESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDIN-GQPA----SECAKEVKPAS 900
+E+ + P W + G CS SC LG RR V C ++ GQ + CA V+P +
Sbjct: 1004 QEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEA 1063
Query: 901 TRPCADHPCP-QWQLGEWSSCSKTCGKGYKKRSLKCLSHDG-GVLSHESCDPLKKP 954
+ PC C +W +G W CS +CG G ++R CL + + C L KP
Sbjct: 1064 SVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKP 1119
Score = 43.9 bits (102), Expect = 7e-04
Identities = 36/113 (31%), Positives = 50/113 (44%), Gaps = 12/113 (10%)
Query: 864 GECSKSCELGWQRRLVECRDINGQ-PASE--CAKEVKPASTRP-CADHPCP-QWQLGEWS 918
G CS SC G C D + P E C KP S R C PCP +WQ + +
Sbjct: 902 GSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLA 960
Query: 919 SCSKTCGKGYKKRSLKCLSHDG-----GVLSHESCDPLKKPKHFIDFCTMAEC 966
+CS +CG+G +R L C G +L C L +P+ + C++ C
Sbjct: 961 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPC 1012
Score = 38.9 bits (89), Expect = 0.023
Identities = 22/55 (40%), Positives = 24/55 (43%), Gaps = 3/55 (5%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQ---PASECAKEVKPASTRPCADHPC 909
W + W ECS SC G QRR C Q PA C KP + R C PC
Sbjct: 1076 WHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 327 bits (838), Expect = 3e-89
Identities = 218/734 (29%), Positives = 324/734 (44%), Gaps = 66/734 (8%)
Query: 249 RKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVK 308
R++R ++E ++ + + H + Y+LT ++ A L + PS+ + +VK
Sbjct: 71 RQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVK 130
Query: 309 ILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDL-CGSQTC 367
++++ + + P +T+N +L + C W + NP D D H D + TR DL
Sbjct: 131 MVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNR 190
Query: 368 DTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDS 427
G+ +G C P+ SC + ED G T AHE+GH F + HD A +G
Sbjct: 191 QVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPG----SGCGPSG 246
Query: 428 HMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQ----NPIQLPGDLPGTSYD 483
H+MAS + WSPCS + S L G C+ D P+ + P PG Y
Sbjct: 247 HVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLYYS 306
Query: 484 ANRQCQFTFGEDSKHCPDAAS---TCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWC 540
AN QC+ FG + C A C L C C P DGT CG KWC
Sbjct: 307 ANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWC 366
Query: 541 INGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEG 600
G+C + + HG W WGP CSR+CGGGV R+C+NP P GG+ C G
Sbjct: 367 SKGRCRSLVELTPI-AAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVG 425
Query: 601 KRVRYRSCNLEDCPDNNGKTFREEQC-EAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCK 659
++ CN + C + F +QC + ++S G W C+
Sbjct: 426 ADLQAEMCNTQAC-EKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCR 484
Query: 660 LICQAKGIGYFFVLQPKVVDGTPCSPD------STSVCVQGQCVKAGCDRIIDSKKKFDK 713
+C+A G + +DGT C P + S+CV G C GCD +DS++ +D+
Sbjct: 485 HMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDR 544
Query: 714 CGVCGGNGSTCKKISGSVTSAKP-GYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKA 772
C VCGG+ STC GS T+ + Y +T+ T++ + R + LA++
Sbjct: 545 CQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANH-----RPLFTHLAVRI 599
Query: 773 ADGTYILNGDYTLS------TLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVL 826
G Y++ G ++S +L +D + V LE IR + PL+E IQV
Sbjct: 600 G-GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVY 658
Query: 827 -----TVGNALRPKIKYTYFVKKKKESFNAIPTFSAWVIEEW----GECSKSCELGWQRR 877
GN RP I +TYF K ++ AWV W G CS SC G +
Sbjct: 659 RRYGEEYGNLTRPDITFTYFQPKPRQ---------AWV---WAAVRGPCSVSCGAGLRWV 706
Query: 878 LVECRDINGQPASECAKEVK-------PASTRPCADHPC-PQWQLGEWSSCSKTCGKGYK 929
C D Q E + V+ PA C PC P W +G++ CS +CG G +
Sbjct: 707 NYSCLD---QARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLR 763
Query: 930 KRSLKCLSHDGGVL 943
+R ++C+ G +L
Sbjct: 764 ERPVRCVEAQGSLL 777
Score = 62.8 bits (151), Expect = 2e-09
Identities = 38/116 (32%), Positives = 55/116 (47%), Gaps = 7/116 (6%)
Query: 846 KESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDIN-GQPA----SECAKEVKPAS 900
+E+ + P W + G CS SC LG RR V C ++ GQ + CA V+P +
Sbjct: 1004 QEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEA 1063
Query: 901 TRPCADHPCP-QWQLGEWSSCSKTCGKGYKKRSLKCLSHDG-GVLSHESCDPLKKP 954
+ PC C +W +G W CS +CG G ++R CL + + C L KP
Sbjct: 1064 SVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKP 1119
Score = 43.9 bits (102), Expect = 7e-04
Identities = 36/113 (31%), Positives = 50/113 (44%), Gaps = 12/113 (10%)
Query: 864 GECSKSCELGWQRRLVECRDINGQ-PASE--CAKEVKPASTRP-CADHPCP-QWQLGEWS 918
G CS SC G C D + P E C KP S R C PCP +WQ + +
Sbjct: 902 GSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLA 960
Query: 919 SCSKTCGKGYKKRSLKCLSHDG-----GVLSHESCDPLKKPKHFIDFCTMAEC 966
+CS +CG+G +R L C G +L C L +P+ + C++ C
Sbjct: 961 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPC 1012
Score = 38.9 bits (89), Expect = 0.023
Identities = 22/55 (40%), Positives = 24/55 (43%), Gaps = 3/55 (5%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQ---PASECAKEVKPASTRPCADHPC 909
W + W ECS SC G QRR C Q PA C KP + R C PC
Sbjct: 1076 WHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 303 bits (777), Expect = 4e-82
Identities = 210/730 (28%), Positives = 313/730 (42%), Gaps = 89/730 (12%)
Query: 249 RKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVK 308
R++R ++E ++ + + H + Y+LT ++ A L + PS+ + +VK
Sbjct: 71 RQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVK 130
Query: 309 ILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDL-CGSQTC 367
++++ + + P +T+N +L + C W + NP D D H D + TR DL
Sbjct: 131 MVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNR 190
Query: 368 DTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDS 427
G+ +G C P+ SC + ED G T AHE+GH F + HD A +G
Sbjct: 191 QVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPG----SGCGPSG 246
Query: 428 HMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQ 487
H+MAS + WSPCS + S L AN Q
Sbjct: 247 HVMASDGAAPRAGLAWSPCSRRQLLSLLS---------------------------ANEQ 279
Query: 488 CQFTFGEDSKHCPDAAS---TCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGK 544
C+ FG + C A C L C C P DGT CG KWC G+
Sbjct: 280 CRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGR 339
Query: 545 CVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVR 604
C + + HG W WGP CSR+CGGGV R+C+NP P GG+ C G ++
Sbjct: 340 CRSLVELTPI-AAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQ 398
Query: 605 YRSCNLEDCPDNNGKTFREEQC-EAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQ 663
CN + C + F +QC + ++S G W C+ +C+
Sbjct: 399 AEMCNTQAC-EKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCR 457
Query: 664 AKGIGYFFVLQPKVVDGTPCSPD------STSVCVQGQCVKAGCDRIIDSKKKFDKCGVC 717
A G + +DGT C P + S+CV G C GCD +DS++ +D+C VC
Sbjct: 458 AIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVC 517
Query: 718 GGNGSTCKKISGSVTSAKP-GYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGT 776
GG+ STC GS T+ + Y +T+ T++ + R + LA++ G
Sbjct: 518 GGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANH-----RPLFTHLAVRIG-GR 571
Query: 777 YILNGDYTLS------TLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVL---- 826
Y++ G ++S +L +D + V LE IR + PL+E IQV
Sbjct: 572 YVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYG 631
Query: 827 -TVGNALRPKIKYTYFVKKKKESFNAIPTFSAWVIEEW----GECSKSCELGWQRRLVEC 881
GN RP I +TYF K ++ AWV W G CS SC G + C
Sbjct: 632 EEYGNLTRPDITFTYFQPKPRQ---------AWV---WAAVRGPCSVSCGAGLRWVNYSC 679
Query: 882 RDINGQPASECAKEVK-------PASTRPCADHPC-PQWQLGEWSSCSKTCGKGYKKRSL 933
D Q E + V+ PA C PC P W +G++ CS +CG G ++R +
Sbjct: 680 LD---QARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPV 736
Query: 934 KCLSHDGGVL 943
+C+ G +L
Sbjct: 737 RCVEAQGSLL 746
Score = 62.8 bits (151), Expect = 2e-09
Identities = 38/116 (32%), Positives = 55/116 (47%), Gaps = 7/116 (6%)
Query: 846 KESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDIN-GQPA----SECAKEVKPAS 900
+E+ + P W + G CS SC LG RR V C ++ GQ + CA V+P +
Sbjct: 973 QEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEA 1032
Query: 901 TRPCADHPCP-QWQLGEWSSCSKTCGKGYKKRSLKCLSHDG-GVLSHESCDPLKKP 954
+ PC C +W +G W CS +CG G ++R CL + + C L KP
Sbjct: 1033 SVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKP 1088
Score = 43.9 bits (102), Expect = 7e-04
Identities = 36/113 (31%), Positives = 50/113 (44%), Gaps = 12/113 (10%)
Query: 864 GECSKSCELGWQRRLVECRDINGQ-PASE--CAKEVKPASTRP-CADHPCP-QWQLGEWS 918
G CS SC G C D + P E C KP S R C PCP +WQ + +
Sbjct: 871 GSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLA 929
Query: 919 SCSKTCGKGYKKRSLKCLSHDG-----GVLSHESCDPLKKPKHFIDFCTMAEC 966
+CS +CG+G +R L C G +L C L +P+ + C++ C
Sbjct: 930 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPC 981
Score = 38.9 bits (89), Expect = 0.023
Identities = 22/55 (40%), Positives = 24/55 (43%), Gaps = 3/55 (5%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQ---PASECAKEVKPASTRPCADHPC 909
W + W ECS SC G QRR C Q PA C KP + R C PC
Sbjct: 1045 WHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 233 bits (593), Expect = 8e-61
Identities = 141/418 (33%), Positives = 194/418 (46%), Gaps = 58/418 (13%)
Query: 561 SWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKT 620
+WG W W CSRTCGGGV + R C + ++GG C G +RSC E CPD +
Sbjct: 28 TWGPWSQWSPCSRTCGGGVSFRERPCYSQ-RRDGGSSCVGPARSHRSCRTESCPDG-ARD 85
Query: 621 FREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDG 680
FR EQC EF A F G W+P Y S ++C+L C KG +++ + VVDG
Sbjct: 86 FRAEQCA---EFDGAEF-QGRRYRWLPYY---SAPNKCELNCIPKGENFYYKHREAVVDG 138
Query: 681 TPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAKPGYHD 740
TPC P VCV G C GCD +DS K+ DKC CGG+G+TC ++G+ +
Sbjct: 139 TPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDA------- 191
Query: 741 IITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLR 800
N A+K G Y LNG +T+ + + +L
Sbjct: 192 -----------------------NDLSRAVKNVRGEYYLNGHWTIEA-ARALPAASTILH 227
Query: 801 Y---SGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFSA 857
Y + A ER+ + P EPL I++ + P + Y Y + ++ S P FS
Sbjct: 228 YERGAEGDLAPERLHARGPTSEPLVIEL--ISQEPNPGVHYEYHLPLRRPS----PGFS- 280
Query: 858 WVIEEWGECSKSCELGWQRRLVECR-DINGQPASECAKEVKPASTRPCADHPCPQ---WQ 913
W W +CS C G Q RLV C D P C ++ +PA R C HPCP+ W+
Sbjct: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPETKRWK 340
Query: 914 LGEWSSCSKTCGKGYKKRSLKCLSHDGG----VLSHESCDPLKKPKHFIDFCTMAECS 967
G W+ CS +CG G + RS+ C+S DG + C L I C + C+
Sbjct: 341 AGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCA 398
Score = 74.7 bits (182), Expect = 4e-13
Identities = 38/105 (36%), Positives = 52/105 (49%), Gaps = 11/105 (10%)
Query: 856 SAWVIEEWGECSKSCELGWQRRLVECRDINGQ--PASECAKEVKPASTRPCADHPCP--- 910
+AW E WGECS SC +G ++R V CR G + C+ E +P T PC CP
Sbjct: 398 AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLS 457
Query: 911 --QWQLGEWSSCSKTCGKGYKKRSLKCL----SHDGGVLSHESCD 949
W +G W CSK+C G ++R + C SH G + + D
Sbjct: 458 DQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVD 502
Score = 64.3 bits (155), Expect = 5e-10
Identities = 36/121 (29%), Positives = 48/121 (39%), Gaps = 8/121 (6%)
Query: 853 PTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEV-------KPASTRPCA 905
P W W CS SC G Q R V C +G E +E KP + + C
Sbjct: 334 PETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACN 393
Query: 906 DHPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAE 965
C W W CS +CG G +KRS+ C G +L +C +P + C +
Sbjct: 394 LQRCAAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPP-LTEPCVHED 452
Query: 966 C 966
C
Sbjct: 453 C 453
Score = 44.7 bits (104), Expect = 4e-04
Identities = 23/55 (41%), Positives = 26/55 (47%), Gaps = 5/55 (9%)
Query: 857 AWVIEEWGECSKSCELGWQRRLVECRDINGQPASECA--KEVKPASTRPCADHPC 909
AW + WG CSKSC G +RR V C P S C + KP PC PC
Sbjct: 460 AWHVGTWGLCSKSCSSGTRRRQVICAI---GPPSHCGSLQHSKPVDVEPCNTQPC 511
Score = 38.5 bits (88), Expect = 0.031
Identities = 42/184 (22%), Positives = 64/184 (34%), Gaps = 27/184 (14%)
Query: 442 PWSPCSA-----------YMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQF 490
PW+PCSA Y I+S +G G + LPG P ++C
Sbjct: 343 PWAPCSASCGGGSQSRSVYCISS---DGAGIQEAVEEAECAGLPGKPPAIQACNLQRC-- 397
Query: 491 TFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCG-EGKWCINGKCVNKT 549
+ P+ CS G + C+ + +C E + + CV++
Sbjct: 398 -----AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHED 452
Query: 550 DRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCN 609
D +H G WG CS++C G + C P + G K V CN
Sbjct: 453 CPLLSDQAWHV-----GTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCN 507
Query: 610 LEDC 613
+ C
Sbjct: 508 TQPC 511
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 202 bits (513), Expect = 2e-51
Identities = 134/442 (30%), Positives = 197/442 (44%), Gaps = 73/442 (16%)
Query: 560 GSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGK 619
G W WGPW +CSRTCGGG Y++R C + K CEG+ +RYR+C+ DCP G
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAGD 87
Query: 620 TFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVD 679
FR +QC AHN+ G EW+P P + C L CQAKG L PKV+D
Sbjct: 88 -FRAQQCSAHNDVKH----HGQFYEWLP--VSNDPDNPCSLKCQAKGTTLVVELAPKVLD 140
Query: 680 GTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISG---SVTSAKP 736
GT C +S +C+ G C GCD + S K D CGVC G+GSTC+ + G S SA
Sbjct: 141 GTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATK 200
Query: 737 GYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKG 796
++ IP G+ +I + + + +L K GT G+ +LS+ ++
Sbjct: 201 SDDTVVAIPYGSRHIRLVLKGP-----DHLYLETKTLQGT---KGENSLSSTGTFLVDNS 252
Query: 797 VVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFS 856
V E +R PL +++ G+A +++ ++ P
Sbjct: 253 SVDFQKFPDK--EILRMAGPLTADFIVKIRNSGSA-DSTVQFIFYQ----------PIIH 299
Query: 857 AWVIEEWGECSKSCELGWQRRLVECRDINGQ----------------------------- 887
W ++ CS +C G+Q EC D+
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
Query: 888 PASECAKEVKPASTRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHD--GGVLSH 945
PAS+ K++ P HP P+W+ W++CS +CG G + R++ C+ D G V S
Sbjct: 360 PASDGYKQIMPYDLY----HPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV 415
Query: 946 ESCDPLKKPKHFI-DFCTMAEC 966
E + PK I C + +C
Sbjct: 416 EEWKCMYTPKMPIAQPCNIFDC 437
Score = 71.2 bits (173), Expect = 4e-12
Identities = 40/110 (36%), Positives = 50/110 (45%), Gaps = 9/110 (8%)
Query: 858 WVIEEWGECSKSCELGWQRRLVEC--RDINGQPAS----ECAKEVKPASTRPCADHPCPQ 911
W W CS SC G Q R V C DI G S +C K +PC CP+
Sbjct: 380 WEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK 439
Query: 912 WQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFC 961
W EWS C+ TCG+G + R + C+ H G + C P KP H + C
Sbjct: 440 WLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCSPKTKP-HIKEEC 486
Score = 63.5 bits (153), Expect = 9e-10
Identities = 34/97 (35%), Positives = 50/97 (51%), Gaps = 8/97 (8%)
Query: 847 ESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVEC-----RDINGQP--ASECAKEVKPA 899
+S N P + W I +W CS +C +G Q R V C R++N A E ++ KP+
Sbjct: 659 KSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPS 718
Query: 900 STRPCADHPCPQ-WQLGEWSSCSKTCGKGYKKRSLKC 935
+ + C CP W +W CS+TCG G +KR + C
Sbjct: 719 TVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLC 755
Score = 59.7 bits (143), Expect = 1e-08
Identities = 33/94 (35%), Positives = 47/94 (50%), Gaps = 11/94 (11%)
Query: 849 FNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQ------PASECAKEVKPASTR 902
FN P AW +W CS++C G Q+R V C+ P + C+ KPA +
Sbjct: 726 FNCPP---AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSAS-KPACQQ 781
Query: 903 PCADHPCP-QWQLGEWSSCSKTCGKGYKKRSLKC 935
C CP +W L +W+ CS +CG+G + RS C
Sbjct: 782 ACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAIC 815
Score = 59.7 bits (143), Expect = 1e-08
Identities = 31/109 (28%), Positives = 45/109 (41%), Gaps = 10/109 (9%)
Query: 856 SAWVIEEWGECSKSCELGWQRRLVECRDINGQPASE------CAKEVK-PASTRPCADHP 908
S W++ W C++SC G Q R V C+ + S C + K P T+ C
Sbjct: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
Query: 909 CPQWQLGEWSSCSKTC---GKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
C +W W C+ C + R + C + DG L E C L +P
Sbjct: 1607 CVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRP 1655
Score = 57.8 bits (138), Expect = 5e-08
Identities = 31/85 (36%), Positives = 44/85 (51%), Gaps = 9/85 (10%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRP------CADHPCP- 910
W E + +CS+SC G Q +V C +N Q + + S RP C PCP
Sbjct: 611 WEYEGFTKCSESCGGGVQEAVVSC--LNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPA 668
Query: 911 QWQLGEWSSCSKTCGKGYKKRSLKC 935
+W++G+WS CS TCG G + R + C
Sbjct: 669 RWEIGKWSPCSLTCGVGLQTRDVFC 693
Score = 56.6 bits (135), Expect = 1e-07
Identities = 27/86 (31%), Positives = 45/86 (52%), Gaps = 7/86 (8%)
Query: 858 WVIEEWGECSKSC---ELGWQRRLVECRDING--QPASECAKEVKPASTRPCADHPCP-Q 911
W WG+C+ C L Q R V C+ +G P+ +C+ +P ST+ C C
Sbjct: 1610 WAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVH 1669
Query: 912 WQLGEWSSCSKTCGK-GYKKRSLKCL 936
W++ W+ C+ TCG G++ R ++C+
Sbjct: 1670 WRVSLWTLCTATCGNYGFQSRRVECV 1695
Score = 51.6 bits (122), Expect = 4e-06
Identities = 34/149 (22%), Positives = 60/149 (40%), Gaps = 34/149 (22%)
Query: 851 AIPTFSAWVIEEWGECSKSCELGWQRRLVEC-------RDINGQPASECAKEVKPASTRP 903
A+ +++ E W C+ +C +G Q R+V C + + P EC + KPAS R
Sbjct: 519 AVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDEC-EGPKPASQRA 577
Query: 904 CADHPCP-------------------------QWQLGEWSSCSKTCGKGYKKRSLKCLSH 938
C PC W+ ++ CS++CG G ++ + CL+
Sbjct: 578 CYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNK 637
Query: 939 DGGVLSHES-CDPLKKPKHFIDFCTMAEC 966
+ E+ C ++P + C + C
Sbjct: 638 QTREPAEENLCVTSRRPPQLLKSCNLDPC 666
Score = 38.9 bits (89), Expect = 0.023
Identities = 49/227 (21%), Positives = 76/227 (33%), Gaps = 53/227 (23%)
Query: 440 SQPWSPCSA-------YMITSFLDNG---------------HGECLMD----KPQNPIQL 473
+Q WSPC+ Y + +D+ EC++ KP+ + +
Sbjct: 442 AQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPV 501
Query: 474 PGDLPGTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTK--------- 524
LP + E+ P+A S C+ GT ++ CQ
Sbjct: 502 EAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVAD 561
Query: 525 -HFPWADGTSCGEGKWCINGKC---VNKTDRKHFDTPFHG--------SWGMWGPWGDCS 572
+G + C G C + + + D F G W G + CS
Sbjct: 562 LPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEG-FTKCS 620
Query: 573 RTCGGGVQYTMRECDN-----PVPKNGGKYCEGKRVRYRSCNLEDCP 614
+CGGGVQ + C N P +N +SCNL+ CP
Sbjct: 621 ESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCP 667
Score = 35.0 bits (79), Expect = 0.34
Identities = 21/58 (36%), Positives = 26/58 (44%), Gaps = 8/58 (13%)
Query: 565 WGP--WGDCSRTCGGGVQ-----YTMRECDNPVPKNGGKYCE-GKRVRYRSCNLEDCP 614
W P W CSRTCGGGVQ R D + +C K ++C +DCP
Sbjct: 732 WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCP 789
Score = 33.9 bits (76), Expect = 0.76
Identities = 20/60 (33%), Positives = 25/60 (41%), Gaps = 6/60 (10%)
Query: 856 SAWVIEEWGECSKSCELGWQRRLVECRDINGQPASE------CAKEVKPASTRPCADHPC 909
S W++ +W ECS SC G Q R CR + S C +S RPC C
Sbjct: 790 SEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATC 849
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 202 bits (513), Expect = 2e-51
Identities = 134/442 (30%), Positives = 197/442 (44%), Gaps = 73/442 (16%)
Query: 560 GSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGK 619
G W WGPW +CSRTCGGG Y++R C + K CEG+ +RYR+C+ DCP G
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAGD 87
Query: 620 TFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVD 679
FR +QC AHN+ G EW+P P + C L CQAKG L PKV+D
Sbjct: 88 -FRAQQCSAHNDVKH----HGQFYEWLP--VSNDPDNPCSLKCQAKGTTLVVELAPKVLD 140
Query: 680 GTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISG---SVTSAKP 736
GT C +S +C+ G C GCD + S K D CGVC G+GSTC+ + G S SA
Sbjct: 141 GTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATK 200
Query: 737 GYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKG 796
++ IP G+ +I + + + +L K GT G+ +LS+ ++
Sbjct: 201 SDDTVVAIPYGSRHIRLVLKGP-----DHLYLETKTLQGT---KGENSLSSTGTFLVDNS 252
Query: 797 VVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFS 856
V E +R PL +++ G+A +++ ++ P
Sbjct: 253 SVDFQKFPDK--EILRMAGPLTADFIVKIRNSGSA-DSTVQFIFYQ----------PIIH 299
Query: 857 AWVIEEWGECSKSCELGWQRRLVECRDINGQ----------------------------- 887
W ++ CS +C G+Q EC D+
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
Query: 888 PASECAKEVKPASTRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHD--GGVLSH 945
PAS+ K++ P HP P+W+ W++CS +CG G + R++ C+ D G V S
Sbjct: 360 PASDGYKQIMPYDLY----HPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV 415
Query: 946 ESCDPLKKPKHFI-DFCTMAEC 966
E + PK I C + +C
Sbjct: 416 EEWKCMYTPKMPIAQPCNIFDC 437
Score = 71.2 bits (173), Expect = 4e-12
Identities = 40/110 (36%), Positives = 50/110 (45%), Gaps = 9/110 (8%)
Query: 858 WVIEEWGECSKSCELGWQRRLVEC--RDINGQPAS----ECAKEVKPASTRPCADHPCPQ 911
W W CS SC G Q R V C DI G S +C K +PC CP+
Sbjct: 380 WEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK 439
Query: 912 WQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFC 961
W EWS C+ TCG+G + R + C+ H G + C P KP H + C
Sbjct: 440 WLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCSPKTKP-HIKEEC 486
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 199 bits (507), Expect = 8e-51
Identities = 132/465 (28%), Positives = 208/465 (44%), Gaps = 90/465 (19%)
Query: 560 GSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGK 619
G+W WG W DCSRTCGGG Y++R C G+ CEG+ +RY++C+ DCP + +
Sbjct: 76 GNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPD-AE 128
Query: 620 TFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVD 679
FR +QC A+N+ G EW+P+Y P C L C A+G L PKV+D
Sbjct: 129 DFRAQQCSAYNDVQY----QGHYYEWLPRYN--DPAAPCALKCHAQGQNLVVELAPKVLD 182
Query: 680 GTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISG---SVTSAKP 736
GT C+ DS +C+ G C GCDR + S K D CGVC G+GSTC+ + G S S +
Sbjct: 183 GTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEK 242
Query: 737 GYHDIITIPTGATNIE----------VKQRNQRGSRNNGSFLAIKAADGTYILNG---DY 783
++I +P G+ ++ ++ + +GS+ SF + G +++ ++
Sbjct: 243 REENVIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSF----NSPGVFLVENTTVEF 298
Query: 784 TLSTLEQDIMYKGVVL-------RYSGSSAALERIRSFSPLKE--------PLTIQV--- 825
+ Q G ++ RY+ + ++ + + P+ P T+
Sbjct: 299 QRGSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGG 358
Query: 826 --LTVGNALRPKIK------YTYFV--------KKKKESFNAIPT--------------- 854
L + ++K Y ++ K K+ S + P+
Sbjct: 359 YQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQP 418
Query: 855 FSAWVIEEWGECSKSCELGWQRRLVEC--RDINGQPAS----ECAKEVKPASTRPCADHP 908
W W CS SC G QRR C ++G+ +C KP + C
Sbjct: 419 LPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFD 478
Query: 909 CPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKK 953
CP+W EWS C+ TCG+G + R + C++H G + C+P K
Sbjct: 479 CPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVG--GCNPQLK 521
Score = 70.9 bits (172), Expect = 6e-12
Identities = 45/127 (35%), Positives = 57/127 (44%), Gaps = 10/127 (7%)
Query: 847 ESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPA--SECAKEVKPASTRPC 904
++ N P W + WG CS +C +G Q R V C PA EC E KP + + C
Sbjct: 696 QACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDE-KPHALQAC 754
Query: 905 ADHPCPQ-WQLGEWSSCSKTCGKGYKKRSLKC--LSHDGGV--LSHESCDPLKKPKHFID 959
CP W + EW CS+TCG G + R + C L DG LS E C K H
Sbjct: 755 NQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSH--K 812
Query: 960 FCTMAEC 966
C +C
Sbjct: 813 SCARTDC 819
Score = 62.0 bits (149), Expect = 3e-09
Identities = 42/120 (35%), Positives = 57/120 (47%), Gaps = 11/120 (9%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPA-----SECAKEVKPASTRPCADHPCP-Q 911
W IEEW +CS++C G Q R V CR + + E + K +S + CA CP
Sbjct: 763 WHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPH 822
Query: 912 WQLGEWSSCSKTCGKGYKKRSLKC--LSHDGG--VLSHESCDPLKKPKHFIDFCTMAECS 967
+G+WS CS +CG G ++R C L+ G LS C L + C M ECS
Sbjct: 823 LAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDL-PGLPLVRSCQMPECS 881
Score = 59.3 bits (142), Expect = 2e-08
Identities = 37/106 (34%), Positives = 48/106 (45%), Gaps = 9/106 (8%)
Query: 858 WVIEEWGECSKSC-ELGWQRRLVECRDINGQPASE--CAKEVKP-ASTRPCADHPCP-QW 912
W W CS +C LG + + +C NGQ SE C KP A PC CP +W
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARW 1487
Query: 913 QLGEWSSCSKTCGKGYKKRSLKCLSHDGG----VLSHESCDPLKKP 954
WS CS +CG+GY R + C V+S +C P +P
Sbjct: 1488 FTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRP 1533
Score = 55.8 bits (133), Expect = 2e-07
Identities = 35/114 (30%), Positives = 49/114 (42%), Gaps = 7/114 (6%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPA---SECAKEVKP-ASTRPCADHPCP-QW 912
W + C+ +C G Q + C I Q S C +P A ++ C PCP +W
Sbjct: 648 WEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRW 707
Query: 913 QLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
+G W CS TCG G + R + CL E C +KP H + C +C
Sbjct: 708 HVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRD-EKP-HALQACNQFDC 759
Score = 53.1 bits (126), Expect = 1e-06
Identities = 31/106 (29%), Positives = 46/106 (43%), Gaps = 15/106 (14%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASE------CAKEVKPASTRPCADHPCPQ 911
W W +CS SC G+ R V C+ + CA + +P +PC HPC Q
Sbjct: 1487 WFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQ 1546
Query: 912 WQLGEWSSCSKTC-GKGYK--KRSLKCLSHDGGVLSHESCDPLKKP 954
W+ G + C C G+ + +R C + S +CD K+P
Sbjct: 1547 WEPG--NRCPGRCMGRAVRMQQRHTACQHNS----SDSNCDDRKRP 1586
Score = 46.2 bits (108), Expect = 1e-04
Identities = 25/77 (32%), Positives = 38/77 (49%), Gaps = 3/77 (3%)
Query: 893 AKEVKPASTRPCADHPC--PQWQLGEWSSCSKTCGK-GYKKRSLKCLSHDGGVLSHESCD 949
A + S P + P P W+ G WS CS TCG G + + +C+ +G +S CD
Sbjct: 1407 ATNTRTNSNDPTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCD 1466
Query: 950 PLKKPKHFIDFCTMAEC 966
L+KP + C + +C
Sbjct: 1467 HLQKPLAGFEPCNIRDC 1483
Score = 42.7 bits (99), Expect = 0.002
Identities = 37/142 (26%), Positives = 54/142 (38%), Gaps = 32/142 (22%)
Query: 853 PTFSAWVIEEWGECSKSCELGWQRRLVECRDI-------NGQPASECAKEVKPASTRPC- 904
PTF + E W CS +C G Q R V+CR + P EC P + RPC
Sbjct: 566 PTF---IPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLP-TERPCL 621
Query: 905 ------------ADHPCPQ-------WQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSH 945
D P P+ W+ ++ C+ TC G+++ CL +
Sbjct: 622 LEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVN 681
Query: 946 ES-CDPLKKPKHFIDFCTMAEC 966
+S CD + +P C C
Sbjct: 682 DSLCDMVHRPPAMSQACNTEPC 703
Score = 37.7 bits (86), Expect = 0.052
Identities = 20/53 (37%), Positives = 24/53 (45%), Gaps = 6/53 (11%)
Query: 568 WGDCSRTCGGGVQYTMREC-----DNPVPKNGGKYCEG-KRVRYRSCNLEDCP 614
W CSRTCGGG Q C D + C+G K ++SC DCP
Sbjct: 768 WQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCP 820
Score = 37.0 bits (84), Expect = 0.089
Identities = 19/53 (35%), Positives = 26/53 (49%), Gaps = 6/53 (11%)
Query: 566 GPWGDCSRTCGGGVQ----YTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCP 614
G WG CS TCG G+Q Y + + P P + + K ++CN DCP
Sbjct: 710 GSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECR--DEKPHALQACNQFDCP 760
Score = 34.3 bits (77), Expect = 0.58
Identities = 17/55 (30%), Positives = 23/55 (41%), Gaps = 3/55 (5%)
Query: 858 WVIEEWGECSKSCELGWQRRLVEC---RDINGQPASECAKEVKPASTRPCADHPC 909
W W C+ +C G+Q R V+C R C ++ KP S R C C
Sbjct: 1601 WHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
Score = 33.5 bits (75), Expect = 0.99
Identities = 20/60 (33%), Positives = 29/60 (48%), Gaps = 13/60 (21%)
Query: 567 PWGDCSRTCGGGVQ---------YTMRECDNPVPKNGGKYCEGKRV-RYRSCNLEDCPDN 616
PW CS TCG GVQ T + + +P+ + CEG ++ R C LE C ++
Sbjct: 572 PWSACSTTCGPGVQVREVKCRVLLTFTQTETELPE---EECEGPKLPTERPCLLEACDES 628
Score = 32.7 bits (73), Expect = 1.7
Identities = 16/49 (32%), Positives = 25/49 (51%), Gaps = 3/49 (6%)
Query: 915 GEWSSCSKTCGKGYKKRSLKCLSH---DGGVLSHESCDPLKKPKHFIDF 960
G+WS CS+TCG G +CL+ +G + +++C P DF
Sbjct: 82 GDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDF 130
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 175 bits (443), Expect = 2e-43
Identities = 140/471 (29%), Positives = 211/471 (44%), Gaps = 54/471 (11%)
Query: 81 FDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNG-DPSSAAAL 139
F + L L LRP++ +APG T++ G K T E L C Y G V G +S+ AL
Sbjct: 116 FGRDLHLRLRPNARLVAPGATMEWQGEKG---TTRVEPLLGSCLYVGDVAGLAEASSVAL 172
Query: 140 SLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNRQGDVGGTCG 199
S C+G+ G + E +FI+PL E+ A E+ + H++ R
Sbjct: 173 SNCDGLAGLIRMEEEEFFIEPL----EKGLAAQEAEQG----RVHVVYR----------- 213
Query: 200 VVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVG---QPTGTGSIRKKRFVSS 256
+ T G + D GA D + +G + + R +R +
Sbjct: 214 ----------RPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRRRARRHAAD 263
Query: 257 HRY-VETMLVADQSMAEFHGSG-LKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVI-H 313
Y +E +L D S+ +FHG ++ YLLTL ++ +Y S+ +++V+V+I+++ +
Sbjct: 264 DDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSY 323
Query: 314 DEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMA 373
+ N + +L N C W P E++D AI TRQD S G A
Sbjct: 324 GKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPS---GMQGYA 380
Query: 374 DVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHD-DAKQCASLNGVNQDSHMMAS 432
V +C P RSC++ +DG +AF AHE GHV M HD +C + +MA
Sbjct: 381 PVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGS---IMAP 437
Query: 433 MLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKP--QNPIQLPGDLPGTSYDANRQCQF 490
++ H WS CS ++ +L + +CL+D P + LP LPG Y N QC+F
Sbjct: 438 LVQAAFHRFHWSRCSQQELSRYLHS--YDCLLDDPFAHDWPALP-QLPGLHYSMNEQCRF 494
Query: 491 TFGEDSKHCP--DAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKW 539
FG C C LWC+ C+TK P DGT C GK+
Sbjct: 495 DFGLGYMMCTAFRTFDPCKQLWCSHPDNPYF-CKTKKGPPLDGTMCAPGKF 544
>gi|226442878 ADAMTS-like 5 [Homo sapiens]
Length = 471
Score = 157 bits (396), Expect = 6e-38
Identities = 116/375 (30%), Positives = 171/375 (45%), Gaps = 53/375 (14%)
Query: 560 GSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGK 619
G W W W CS +CG GV R C + G + C G YR C L DCP
Sbjct: 36 GEWTPWVSWTRCSSSCGRGVSVRSRRC---LRLPGEEPCWGDSHEYRLCQLPDCPPG-AV 91
Query: 620 TFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVD 679
FR+ QC +N + G+ +W+P + ++C L C A+G ++ +V+D
Sbjct: 92 PFRDLQCALYN--GRPVLGTQKTYQWVPFHGA---PNQCDLNCLAEGHAFYHSFG-RVLD 145
Query: 680 GTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSV--TSAKPG 737
GT CSP + VCV G+C+ AGCD ++ S D+CG CGG +C + A G
Sbjct: 146 GTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAG 205
Query: 738 YHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLS---TLEQDIMY 794
Y ++ IP GA +I V+ R SRN+ LA+ DG Y+LNG + +S T E
Sbjct: 206 YWNVTLIPEGARHIRVEHR----SRNH---LALMGGDGRYVLNGHWVVSPPGTYEA---- 254
Query: 795 KGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPT 854
G + Y+ + E +++ P L +QVL P I++ +++ +++ S
Sbjct: 255 AGTHVVYTRDTGPQETLQAAGPTSHDLLLQVLL--QEPNPGIEFEFWLPRERYS-----P 307
Query: 855 FSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQL 914
F A V LGW R + R + QP + A V PA T A PCP
Sbjct: 308 FQARV----------QALGWPLRQPQPRGVEPQPPA--APAVTPAQTPTLAPDPCP---- 351
Query: 915 GEWSSCSKTCGKGYK 929
C T G+ ++
Sbjct: 352 ----PCPDTRGRAHR 362
Score = 32.3 bits (72), Expect = 2.2
Identities = 15/50 (30%), Positives = 22/50 (44%), Gaps = 7/50 (14%)
Query: 917 WSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
W+ CS +CG+G RS +CL G +P H C + +C
Sbjct: 44 WTRCSSSCGRGVSVRSRRCLRLPGE-------EPCWGDSHEYRLCQLPDC 86
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 147 bits (371), Expect = 5e-35
Identities = 118/406 (29%), Positives = 184/406 (45%), Gaps = 57/406 (14%)
Query: 598 CEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDR 657
C G +Y+ CN CP+++ ++ RE QC ++N +K G EW P +A V +
Sbjct: 291 CIGAYRQYKLCNTNVCPESS-RSIREVQCASYN--NKPFMGR--FYEWEP-FAEVKGNRK 344
Query: 658 CKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVC 717
C+L CQA G ++ KV+DGTPC + T++CV GQC GCD + S K DKCGVC
Sbjct: 345 CELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVC 404
Query: 718 GGNGSTCKKISGSVTSA--KPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADG 775
GG+ + C+ +SG A GYH ++ IP GAT I + + + + ++LA+++ G
Sbjct: 405 GGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYK-----SNNYLALRSRSG 459
Query: 776 TYILNGDYTLSTLEQDIMYK--GVVLRYSG----SSAALERIRSFSPLKEPLTIQVLTVG 829
I+NG++ +++ Y+ G + Y SS A E + P E + V +
Sbjct: 460 RSIINGNW---AIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNE--ILDVYMIH 514
Query: 830 NALRPKIKYTYFVKKKKESFNAIP-------TFSAWVIEEWGECSKSCELGWQR-RLVEC 881
P + Y Y + +P F+ ++ E +S E G Q+ R E
Sbjct: 515 QQPNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMVTE----GRSQEEGEQKGRNEEK 570
Query: 882 RDINGQP----ASECAKEVKPASTRPCADH-------PCPQ---------WQLGEWSSCS 921
D+ G+ SE A+ + H P PQ W+ + CS
Sbjct: 571 EDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECS 630
Query: 922 KTCGKGYKKRSLKCLSHDGGVLSHES-CDPLKKPKHFIDFCTMAEC 966
TCGKG + +C+ + ES CD KP + C + C
Sbjct: 631 TTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPC 676
Score = 89.7 bits (221), Expect = 1e-17
Identities = 49/130 (37%), Positives = 68/130 (52%), Gaps = 9/130 (6%)
Query: 845 KKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDING------QPASECAKEVKP 898
++E N P + W I EW ECSK+C LG Q R V CR + QP C KP
Sbjct: 667 EEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQP-YRCQHLEKP 725
Query: 899 ASTRPCADHPCPQWQL-GEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHF 957
+T C C +WQ+ +W+SCS CG G + R +KC+S+ G V+ E C+ +P
Sbjct: 726 ETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPND- 784
Query: 958 IDFCTMAECS 967
I+ C M C+
Sbjct: 785 IENCDMGPCA 794
Score = 69.7 bits (169), Expect = 1e-11
Identities = 41/115 (35%), Positives = 55/115 (47%), Gaps = 9/115 (7%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQP-----ASECAKEVKPASTRPCADHPC-PQ 911
W W +CS C G Q+R V C N SEC+ KP S + C PC +
Sbjct: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAK 915
Query: 912 WQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
W EWS CSK+C G++ R ++CLS D + CDP KP+ + C +C
Sbjct: 916 WFSTEWSMCSKSCQGGFRVREVRCLSDD--MTLSNLCDPQLKPEE-RESCNPQDC 967
Score = 66.2 bits (160), Expect = 1e-10
Identities = 37/111 (33%), Positives = 51/111 (45%), Gaps = 10/111 (9%)
Query: 853 PTFSAWVIEEWGE-CSKSCELGWQRRLVEC--RDINGQPASECAKEVKPASTRPCADHPC 909
P +W + EW E CS C G + R V C ++ P C +PA PC + PC
Sbjct: 792 PCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNN-RPAEATPCDNGPC 850
Query: 910 P---QWQLGEWSSCSKTCGKGYKKRSLKCLSHDGG---VLSHESCDPLKKP 954
+W G WS CS CG G ++R + C+ + VL C L+KP
Sbjct: 851 TGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKP 901
Score = 45.4 bits (106), Expect = 3e-04
Identities = 16/27 (59%), Positives = 17/27 (62%)
Query: 560 GSWGMWGPWGDCSRTCGGGVQYTMREC 586
G WG WGPW CSR+C GGV R C
Sbjct: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
Score = 41.2 bits (95), Expect = 0.005
Identities = 19/64 (29%), Positives = 31/64 (48%)
Query: 846 KESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCA 905
++S + P + W EW CSKSC+ G++ R V C + ++ C ++KP C
Sbjct: 904 QQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCN 963
Query: 906 DHPC 909
C
Sbjct: 964 PQDC 967
Score = 34.7 bits (78), Expect = 0.44
Identities = 34/122 (27%), Positives = 40/122 (32%), Gaps = 29/122 (23%)
Query: 506 CSTLWCTGTSGGVLVCQTKHFPWADGTSCG-----EGKWCINGKCVNKTDRKHFDTPFHG 560
CS G +VC T H CG E C NG C K +
Sbjct: 806 CSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAEATPCDNGPCTGKVE---------- 855
Query: 561 SWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKY-------CE--GKRVRYRSCNLE 611
W G W CS CG G Q C V KN + C K +SC+L+
Sbjct: 856 -W-FAGSWSQCSIECGSGTQQREVIC---VRKNADTFEVLDPSECSFLEKPPSQQSCHLK 910
Query: 612 DC 613
C
Sbjct: 911 PC 912
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 140 bits (353), Expect = 6e-33
Identities = 95/294 (32%), Positives = 141/294 (47%), Gaps = 30/294 (10%)
Query: 562 WGMWGPWGDCSRTCGGGVQYTMREC----DNPVPKNGGKYCEGKRVRYRSCNLEDCPDNN 617
WG W W CSR+CGGGV R C VP G + C G RY+ C +++CP +
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPD- 108
Query: 618 GKTFREEQCEAHNEFSKASFGSGPAVEWIP----KYAGVSPKDRCKLICQAKGIGYFFVL 673
G++FREEQC + N + +G +W P Y +S K C L C G ++
Sbjct: 109 GRSFREEQCVSFN----SHVYNGRTHQWKPLYPDDYVHISSKP-CDLHCTTVD-GQRQLM 162
Query: 674 QPKVVDGTPCS-PDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVT 732
P DGT C D VCV G+C GCD ++ S DKCG+C G+GS+C ++G+
Sbjct: 163 VP-ARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYR 221
Query: 733 --SAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQ 790
+A GY + IP GA +I++ +R + + LA+ G Y NG+Y + + +
Sbjct: 222 KGNAHLGYSLVTHIPAGARDIQIVER-----KKSADVLALADEAGYYFFNGNYKVDS-PK 275
Query: 791 DIMYKGVVLRYSGS----SAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTY 840
+ G V++Y +E I + P + L + V N P I + Y
Sbjct: 276 NFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWN-QNGKSPSITFEY 328
Score = 82.0 bits (201), Expect = 2e-15
Identities = 41/108 (37%), Positives = 53/108 (49%), Gaps = 6/108 (5%)
Query: 853 PTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQ--PASECAKEVKPASTRPCADHPCP 910
P W + +WG CS SC G R V C+ +G+ P S+C E KP + PC D CP
Sbjct: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCP 795
Query: 911 -QWQLGEWSSCSKTCGKGYKKRSLKCLSHDGG---VLSHESCDPLKKP 954
W +W C+ TCG+G KKR + C+ G S C KKP
Sbjct: 796 AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKP 843
Score = 81.3 bits (199), Expect = 4e-15
Identities = 38/102 (37%), Positives = 54/102 (52%), Gaps = 8/102 (7%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDI-NGQPAS----ECAKEVKPASTRPCADHPCPQW 912
W+ ++W C+ +C G ++RLV C ++ NG+P + EC KP C + PC +W
Sbjct: 798 WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKW 857
Query: 913 QLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
WS C+KTCG G + R +KC G CDPL KP
Sbjct: 858 YTSPWSECTKTCGVGVRMRDVKCYQ---GTDIVRGCDPLVKP 896
Score = 63.9 bits (154), Expect = 7e-10
Identities = 32/99 (32%), Positives = 44/99 (44%), Gaps = 6/99 (6%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDIN-GQPASECAKEVKPASTRPCADHPCP-QWQLG 915
W + EW EC+ C R V RDI + C +P + C PC QW +
Sbjct: 689 WEMSEWSECTAKCG----ERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVS 744
Query: 916 EWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
+W CS +CG+G R + C + DG V+ C KP
Sbjct: 745 DWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKP 783
Score = 62.8 bits (151), Expect = 2e-09
Identities = 34/107 (31%), Positives = 51/107 (47%), Gaps = 16/107 (14%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDING--------QPASECAKEVKPASTRPCADHPC 909
W W ECS++C G+Q R+V C + E A+ V+P + C + C
Sbjct: 626 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
Query: 910 -PQWQLGEWSSCSKTCG-KGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
PQW++ EWS C+ CG + R ++C S D + CDP +P
Sbjct: 686 GPQWEMSEWSECTAKCGERSVVTRDIRC-SED-----EKLCDPNTRP 726
Score = 53.1 bits (126), Expect = 1e-06
Identities = 46/168 (27%), Positives = 67/168 (39%), Gaps = 31/168 (18%)
Query: 775 GTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRP 834
G Y+LNG Y L D R + SS S +P T + + GN
Sbjct: 506 GPYLLNGSYL--ELSSD--------RVANSS-------SEAPFPNVSTSLLTSAGNRTH- 547
Query: 835 KIKYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAK 894
K K +K+ + + W + CS +C G C +G +
Sbjct: 548 --KARTRPKARKQGVSPADMYR-WKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYC 604
Query: 895 EVKPASTRP------CADHPC-PQWQLGEWSSCSKTCGKGYKKRSLKC 935
+ A TRP CA C P+W+ WS CS+TCG+GY+ R ++C
Sbjct: 605 D---ALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRC 649
Score = 43.1 bits (100), Expect = 0.001
Identities = 18/56 (32%), Positives = 26/56 (46%)
Query: 911 QWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
+W+L CS TC G C+ +DG + CD L +P+ +FC EC
Sbjct: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC 622
Score = 38.5 bits (88), Expect = 0.031
Identities = 18/53 (33%), Positives = 24/53 (45%), Gaps = 1/53 (1%)
Query: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCP 910
W W EC+K+C +G + R V+C C VKP + C PCP
Sbjct: 857 WYTSPWSECTKTCGVGVRMRDVKCYQ-GTDIVRGCDPLVKPVGRQACDLQPCP 908
Score = 33.5 bits (75), Expect = 0.99
Identities = 16/48 (33%), Positives = 25/48 (52%)
Query: 567 PWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCP 614
PW +C++TCG GV+ +C G K V ++C+L+ CP
Sbjct: 861 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP 908
Score = 30.8 bits (68), Expect = 6.4
Identities = 10/19 (52%), Positives = 13/19 (68%)
Query: 568 WGDCSRTCGGGVQYTMREC 586
W +CSRTCG G Q+ + C
Sbjct: 631 WSECSRTCGEGYQFRVVRC 649
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,028,784
Number of Sequences: 37866
Number of extensions: 2336797
Number of successful extensions: 8277
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 94
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 6865
Number of HSP's gapped (non-prelim): 783
length of query: 967
length of database: 18,247,518
effective HSP length: 112
effective length of query: 855
effective length of database: 14,006,526
effective search space: 11975579730
effective search space used: 11975579730
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.