Search of human proteins with 5031613

Search of human proteins with 5031613

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5031613 growth differentiation factor 11 precursor [Homo
sapiens]
         (407 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5031613 growth differentiation factor 11 precursor [Homo sapi...   843   0.0  
gi|4885259 myostatin [Homo sapiens]                                   486   e-137
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]      129   6e-30
gi|4504699 inhibin beta A precursor [Homo sapiens]                    112   6e-25
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]          100   2e-21
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa...    99   7e-21
gi|4507465 transforming growth factor, beta 3 [Homo sapiens]           99   7e-21
gi|13899338 activin beta E [Homo sapiens]                              99   9e-21
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi...    97   3e-20
gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ...    97   3e-20
gi|63025222 transforming growth factor, beta 1 [Homo sapiens]          96   6e-20
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap...    94   3e-19
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap...    88   1e-17
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]       87   2e-17
gi|61835232 growth differentiation factor 7 preproprotein [Homo ...    86   8e-17
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa...    85   1e-16
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa...    85   1e-16
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa...    85   1e-16
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi...    84   2e-16
gi|48475062 growth differentiation factor 6 precursor [Homo sapi...    84   2e-16
gi|4503969 growth differentiation factor 5 preproprotein [Homo s...    83   4e-16
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa...    79   7e-15
gi|10190670 growth differentiation factor 3 precursor [Homo sapi...    79   1e-14
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa...    78   2e-14
gi|145611428 bone morphogenetic protein 8A [Homo sapiens]              77   2e-14
gi|4826740 growth differentiation factor 10 precursor [Homo sapi...    73   4e-13
gi|110349792 growth differentiation factor 1 [Homo sapiens]            72   1e-12
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]      69   6e-12
gi|7705308 growth differentiation factor 2 [Homo sapiens]              67   2e-11
gi|222352098 nodal precursor [Homo sapiens]                            65   8e-11

>gi|5031613 growth differentiation factor 11 precursor [Homo
           sapiens]
          Length = 407

 Score =  843 bits (2178), Expect = 0.0
 Identities = 407/407 (100%), Positives = 407/407 (100%)

Query: 1   MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPD 60
           MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPD
Sbjct: 1   MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPD 60

Query: 61  GCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQ 120
           GCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQ
Sbjct: 61  GCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQ 120

Query: 121 GDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQL 180
           GDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQL
Sbjct: 121 GDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQL 180

Query: 181 WVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDF 240
           WVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDF
Sbjct: 181 WVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDF 240

Query: 241 KQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNL 300
           KQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNL
Sbjct: 241 KQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNL 300

Query: 301 GLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQ 360
           GLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQ
Sbjct: 301 GLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQ 360

Query: 361 QANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS 407
           QANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS
Sbjct: 361 QANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS 407


>gi|4885259 myostatin [Homo sapiens]
          Length = 375

 Score =  486 bits (1250), Expect = e-137
 Identities = 227/347 (65%), Positives = 279/347 (80%), Gaps = 11/347 (3%)

Query: 62  CPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQG 121
           C  C WRQ+++  R+E+IK QILSKLRL+ APNIS++V++QLLPKAPPL++++D +D Q 
Sbjct: 39  CNACTWRQNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQR 98

Query: 122 DALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQLW 181
           D    +  LE+D+YHATTET+I+M  E+D  +Q DG P CC F FS K+ + KV+KAQLW
Sbjct: 99  DD-SSDGSLEDDDYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLW 157

Query: 182 VYLRPVPRPATVYLQILRL-KPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDF 240
           +YLRPV  P TV++QILRL KP+           G R+  IRSLK++++  +G WQSID 
Sbjct: 158 IYLRPVETPTTVFVQILRLIKPMKD---------GTRYTGIRSLKLDMNPGTGIWQSIDV 208

Query: 241 KQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNL 300
           K VL +W +QP+SN GIEI A D +G DLAVT  GPG +GL+PF+E++V +  KRSRR+ 
Sbjct: 209 KTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDF 268

Query: 301 GLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQ 360
           GLDCDEHS+ESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSG+CE++F+QKYPHTHLV 
Sbjct: 269 GLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVH 328

Query: 361 QANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS 407
           QANPRGSAGPCCTPTKMSPINMLYFN K+QIIYGKIP MVVDRCGCS
Sbjct: 329 QANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS 375


>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
          Length = 407

 Score =  129 bits (323), Expect = 6e-30
 Identities = 115/417 (27%), Positives = 180/417 (43%), Gaps = 51/417 (12%)

Query: 27  GPAAAAAAAAAAAAAGVG----GERSSRPAPSVAPEP----------DGCPVCVWRQHSR 72
           G A  AA     AA  +G    G  +  P P+  P P          D C  C   +   
Sbjct: 6   GRALGAACLLLLAAGWLGPEAWGSPTPPPTPAAPPPPPPPGSPGGSQDTCTSCGGFRRPE 65

Query: 73  ELR------LESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQP 126
           EL       LE++K  ILS+L+++  PNI+  V     PKA  +  +  LH  +      
Sbjct: 66  ELGRVDGDFLEAVKRHILSRLQMRGRPNITHAV-----PKAAMVTALRKLHAGKVREDGR 120

Query: 127 EDFLEEDEYHATTETVISMAQETDPAVQTDG---SPLCCHFHFSPKVMFTK-VLKAQLWV 182
            +    D + +          E     +TDG   S +  +F  S +      V++A LW+
Sbjct: 121 VEIPHLDGHASPGADGQERVSEIISFAETDGLASSRVRLYFFISNEGNQNLFVVQASLWL 180

Query: 183 YLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQ 242
           YL+ +P    V  +  R K          G G R ++  + + ++   RSG W +    +
Sbjct: 181 YLKLLPY---VLEKGSRRKVRVKVYFQEQGHGDRWNMVEKRVDLK---RSG-WHTFPLTE 233

Query: 243 VLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSR-RNLG 301
            + + F + +    +++         +    + PG E   PF+ ++      R R R  G
Sbjct: 234 AIQALFERGERRLNLDVQCDSCQELAVVPVFVDPGEESHRPFVVVQARLGDSRHRIRKRG 293

Query: 302 LDCDEHSSESRCCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMFMQKYP------ 354
           L+CD  ++   CCR    +DF   GW DWIIAP  Y  NYC G C   ++   P      
Sbjct: 294 LECDGRTN--LCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCP-AYLAGVPGSASSF 350

Query: 355 HTHLVQQANPRG----SAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS 407
           HT +V Q   RG    +   CC PTK+S ++MLYF+D+  I+   +P M+V+ CGC+
Sbjct: 351 HTAVVNQYRMRGLNPGTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGCA 407


>gi|4504699 inhibin beta A precursor [Homo sapiens]
          Length = 426

 Score =  112 bits (280), Expect = 6e-25
 Identities = 116/423 (27%), Positives = 181/423 (42%), Gaps = 80/423 (18%)

Query: 49  SRPAP-----SVAPEPDGCPVCVWRQ---HSRELRLESIKSQILSKLRLKEAPNISREVV 100
           S P P     S AP+   C +    +   +S+   +E++K  IL+ L LK+ P++++ V 
Sbjct: 20  SSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKKHILNMLHLKKRPDVTQPV- 78

Query: 101 KQLLPKAPPLQQILDLHDF---QGDALQPEDFL----EEDEYHATTETVISMAQETDPAV 153
               PKA  L  I  LH     +   ++ ED +    E +E    T  +I+ A E+  A 
Sbjct: 79  ----PKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFA-ESGTAR 133

Query: 154 QTDGSPLCCHFHFSPKVMFTKVL-KAQLWVYLRPVPRP------ATVYLQILRLKPL--- 203
           +T       HF  S +     V+ +A++W++L+ VP+        T+ L   +  P    
Sbjct: 134 KT------LHFEISKEGSDLSVVERAEVWLFLK-VPKANRTRTKVTIRLFQQQKHPQGSL 186

Query: 204 -TGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAF 262
            TGE     G  G R   + S K+ + +R   W        +     Q +S+  + I   
Sbjct: 187 DTGEEAEEVGLKGERSELLLSEKV-VDARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACE 245

Query: 263 DPSGTDLAVTSLGP--------------GAEG-----------LHPFMEL--RVLENTKR 295
               +  ++  LG               G EG             PF+ L  R  E+   
Sbjct: 246 QCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHPH 305

Query: 296 SRRNLGLDCDEHSSESRCCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQC--------- 345
            RR  GL+CD     + CC+    V F+  GW DWIIAP  Y ANYC G+C         
Sbjct: 306 RRRRRGLECD--GKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSG 363

Query: 346 -EYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRC 404
               F     + + ++  +P  +   CC PTK+ P++MLY++D Q II   I  M+V+ C
Sbjct: 364 SSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEEC 423

Query: 405 GCS 407
           GCS
Sbjct: 424 GCS 426


>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
          Length = 352

 Score =  100 bits (250), Expect = 2e-21
 Identities = 99/375 (26%), Positives = 148/375 (39%), Gaps = 54/375 (14%)

Query: 51  PAPSVAPEPDG-CPVC----VWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLP 105
           P     P   G CP C    +  +  REL L+  K  IL KL L + P ++R V +  L 
Sbjct: 14  PTTVATPRAGGQCPACGGPTLELESQRELLLDLAKRSILDKLHLTQRPTLNRPVSRAALR 73

Query: 106 KAPPLQQILDLHDFQGDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFH 165
            A     +  LH     AL  ++  +E E  +  ET +S   +T          L  HF 
Sbjct: 74  TA-----LQHLHGVPQGALLEDNREQECEIISFAETGLSTINQTR---------LDFHFS 119

Query: 166 FSPKVMFTKVLKAQLWVYLR-PVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSL 224
                   +V +A L  +++ P     T+ +++L L P     T              + 
Sbjct: 120 SDRTAGDREVQQASLMFFVQLPSNTTWTLKVRVLVLGPHNTNLTL-------------AT 166

Query: 225 KIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPF 284
           +  L   +  W  +       +   Q      + +         +A +S+  G     PF
Sbjct: 167 QYLLEVDASGWHQLPLGPEAQAACSQGHLTLELVLEG------QVAQSSVILGGAAHRPF 220

Query: 285 MELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAFGW-DWIIAPKRYKANYCSG 343
           +  RV    K      G+DC   S    CCR    VDF   GW DWII P+ Y  N+C G
Sbjct: 221 VAARVRVGGKHQIHRRGIDCQGGSR--MCCRQEFFVDFREIGWHDWIIQPEGYAMNFCIG 278

Query: 344 QCEYMFMQKYP------HTHLVQQANPRGSAGP-----CCTPTKMSPINMLYFNDKQQII 392
           QC  + +   P      HT ++       +AG      CC PT   P+++LY++    I+
Sbjct: 279 QCP-LHIAGMPGIAASFHTAVLNLLKANTAAGTTGGGSCCVPTARRPLSLLYYDRDSNIV 337

Query: 393 YGKIPGMVVDRCGCS 407
              IP MVV+ CGCS
Sbjct: 338 KTDIPDMVVEACGCS 352


>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
           sapiens]
          Length = 414

 Score = 99.0 bits (245), Expect = 7e-21
 Identities = 99/398 (24%), Positives = 149/398 (37%), Gaps = 84/398 (21%)

Query: 75  RLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQP-------- 126
           R+E+I+ QILSKL+L   P    E       + PP  +++ +++   D LQ         
Sbjct: 36  RIEAIRGQILSKLKLTSPPEDYPEP-----EEVPP--EVISIYNSTRDLLQEKASRRAAA 88

Query: 127 -EDFLEEDEYHATTETVISMAQ---ETDPAVQTDGSPLCCHFHFSPKVM---FTKVLKAQ 179
            E    ++EY+A     I M       +    T   P      F    M    + ++KA+
Sbjct: 89  CERERSDEEYYAKEVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAE 148

Query: 180 LWVYLRP-----VPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGH 234
             V+        VP       QIL+ K LT           +R+I  + +K       G 
Sbjct: 149 FRVFRLQNPKARVPEQRIELYQILKSKDLTSPT--------QRYIDSKVVKTRAE---GE 197

Query: 235 WQSIDFKQVLHSWFRQPQSNWGIEINAFDP------------------------------ 264
           W S D    +H W      N G +I+   P                              
Sbjct: 198 WLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTS 257

Query: 265 ---SGTDLAVTSLGPGAEGLHPFMELRVL--------ENTKRSRRNLGLDCDEHSSESRC 313
              SG    + S      G  P + L +L        +  +R +R L       + +  C
Sbjct: 258 TYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNC 317

Query: 314 CRYPLTVDFEA-FGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTH---LVQQANPRGSAG 369
           C  PL +DF+   GW WI  PK Y AN+C+G C Y++     H+    L    NP  SA 
Sbjct: 318 CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASAS 377

Query: 370 PCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS 407
           PCC    + P+ +LY+  K   I  ++  M+V  C CS
Sbjct: 378 PCCVSQDLEPLTILYYIGKTPKI-EQLSNMIVKSCKCS 414


>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
          Length = 412

 Score = 99.0 bits (245), Expect = 7e-21
 Identities = 104/399 (26%), Positives = 165/399 (41%), Gaps = 81/399 (20%)

Query: 70  HSRELRLESIKSQILSKLRLKEAPN--ISREVVKQLLPKAPPLQQILD-LHDFQGDALQP 126
           H ++ R+E+I+ QILSKLRL   P   +   V  Q+L      +++L+ +H  + +    
Sbjct: 34  HIKKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQ 93

Query: 127 EDFLEEDEYHATT----ETVISMAQETDPAVQTDG-SPLCCHFHFSP-KVMFTKVLKAQL 180
           E+   E EY+A      + +  +A+  + AV   G +     F+ S  +   T + +A+ 
Sbjct: 94  EN--TESEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEF 151

Query: 181 WVYLRPVPRPATV-------YLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSG 233
            V LR VP P++          QILR      +    GG    +++  R         + 
Sbjct: 152 RV-LR-VPNPSSKRNEQRIELFQILRPDEHIAKQRYIGG----KNLPTRG--------TA 197

Query: 234 HWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRV---- 289
            W S D    +  W  + +SN G+EI+   P  T       G   E +H  ME++     
Sbjct: 198 EWLSFDVTDTVREWLLRRESNLGLEISIHCPCHT---FQPNGDILENIHEVMEIKFKGVD 254

Query: 290 ---------------------------------LENT----KRSRRNLGLDCDEHSSESR 312
                                            L+N     +R +R L  +    + E  
Sbjct: 255 NEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEEN 314

Query: 313 CCRYPLTVDF-EAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHT---HLVQQANPRGSA 368
           CC  PL +DF +  GW W+  PK Y AN+CSG C Y+      H+    L    NP  SA
Sbjct: 315 CCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASA 374

Query: 369 GPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS 407
            PCC P  + P+ +LY+  +   +  ++  MVV  C CS
Sbjct: 375 SPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKCS 412


>gi|13899338 activin beta E [Homo sapiens]
          Length = 350

 Score = 98.6 bits (244), Expect = 9e-21
 Identities = 101/370 (27%), Positives = 144/370 (38%), Gaps = 69/370 (18%)

Query: 62  CPVC----VWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLH 117
           CP C    +  Q  R L LE  K QIL  L L   P I+    +  L +A        L 
Sbjct: 26  CPSCGGSKLAPQAERALVLELAKQQILDGLHLTSRPRITHPPPQAALTRA--------LR 77

Query: 118 DFQGDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLK 177
             Q  ++ P             E VIS A  TD    T        FH S       +  
Sbjct: 78  RLQPGSVAP----------GNGEEVISFATVTD---STSAYSSLLTFHLSTPRSH-HLYH 123

Query: 178 AQLWVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQS 237
           A+LW+++ P   P T+ L+I R  P             RR    R+L  E H  +  W +
Sbjct: 124 ARLWLHVLPT-LPGTLCLRIFRWGPR------------RRRQGSRTLLAEHHITNLGWHT 170

Query: 238 IDFKQVLHSWFRQPQSN-WGIEINAFDPSGTDLAVTS---LGPGAEGLHPFMELRVLENT 293
           +       S  R  +S    ++++     G          L   A    PF+EL++  N 
Sbjct: 171 LTLPS---SGLRGEKSGVLKLQLDCRPLEGNSTVTGQPRRLLDTAGHQQPFLELKIRANE 227

Query: 294 KRSRRNLGLDCDEHSSESRCCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMFMQK 352
             + R          +   CCR    VDF+  GW DWI+ P+ Y+ NYCSGQC       
Sbjct: 228 PGAGRARRRTPTCEPATPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCP------ 281

Query: 353 YPHT---------------HLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIP 397
            PH                 L++  NP  ++  CC PT   P+++LY +    ++   +P
Sbjct: 282 -PHLAGSPGIAASFHSAVFSLLKANNPWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVP 340

Query: 398 GMVVDRCGCS 407
            MVV+ CGCS
Sbjct: 341 DMVVEACGCS 350


>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
           sapiens]
          Length = 513

 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 64/208 (30%), Positives = 88/208 (42%), Gaps = 36/208 (17%)

Query: 235 WQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLG----PGAEGLHPFM----- 285
           W   D     + W   PQ N G++++     G  +   + G     G     PFM     
Sbjct: 305 WLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFK 364

Query: 286 ----ELRVLENTKRSRRNLGLD--------------CDEHSSESR--CCRYPLTVDFEAF 325
                +R   +    RR    +               D +SSE +  C ++ L V F+  
Sbjct: 365 VSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQDL 424

Query: 326 GW-DWIIAPKRYKANYCSGQCEYMFMQKYPHTH------LVQQANPRGSAGPCCTPTKMS 378
           GW DWIIAPK Y ANYC G+C +        T+      LV   NP     PCC PTK++
Sbjct: 425 GWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLN 484

Query: 379 PINMLYFNDKQQIIYGKIPGMVVDRCGC 406
            I++LYF+D   +I  K   MVV  CGC
Sbjct: 485 AISVLYFDDNSNVILKKYRNMVVRACGC 512


>gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
           sapiens]
          Length = 442

 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 101/426 (23%), Positives = 154/426 (36%), Gaps = 112/426 (26%)

Query: 75  RLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQP-------- 126
           R+E+I+ QILSKL+L   P    E       + PP  +++ +++   D LQ         
Sbjct: 36  RIEAIRGQILSKLKLTSPPEDYPEP-----EEVPP--EVISIYNSTRDLLQEKASRRAAA 88

Query: 127 -EDFLEEDEYHATTETVISM-----AQETDPAVQTDGSP-----------LCCHFHFSPK 169
            E    ++EY+A     I M     ++   P V T               LC +    P 
Sbjct: 89  CERERSDEEYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPP 148

Query: 170 VMF------------------TKVLKAQLWVYLRP-----VPRPATVYLQILRLKPLTGE 206
             +                  + ++KA+  V+        VP       QIL+ K LT  
Sbjct: 149 TFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSP 208

Query: 207 GTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDP-- 264
                    +R+I  + +K       G W S D    +H W      N G +I+   P  
Sbjct: 209 T--------QRYIDSKVVKTRAE---GEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCC 257

Query: 265 -------------------------------SGTDLAVTSLGPGAEGLHPFMELRVL--- 290
                                          SG    + S      G  P + L +L   
Sbjct: 258 TFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSY 317

Query: 291 -----ENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEA-FGWDWIIAPKRYKANYCSGQ 344
                +  +R +R L       + +  CC  PL +DF+   GW WI  PK Y AN+C+G 
Sbjct: 318 RLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGA 377

Query: 345 CEYMFMQKYPHTH---LVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVV 401
           C Y++     H+    L    NP  SA PCC    + P+ +LY+  K   I  ++  M+V
Sbjct: 378 CPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNMIV 436

Query: 402 DRCGCS 407
             C CS
Sbjct: 437 KSCKCS 442


>gi|63025222 transforming growth factor, beta 1 [Homo sapiens]
          Length = 390

 Score = 95.9 bits (237), Expect = 6e-20
 Identities = 97/365 (26%), Positives = 148/365 (40%), Gaps = 51/365 (13%)

Query: 75  RLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHD-----FQGDALQPEDF 129
           R+E+I+ QILSKLRL   P+         +P  P  + +L L++       G++ +PE  
Sbjct: 45  RIEAIRGQILSKLRLASPPSQGE------VPPGPLPEAVLALYNSTRDRVAGESAEPEPE 98

Query: 130 LEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQLWVYLRPVPR 189
            E D Y      V+ +    +   +   S    +  F+     T  L+         VP 
Sbjct: 99  PEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFN-----TSELR-------EAVPE 146

Query: 190 PATVY---LQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHS 246
           P  +    L++LRLK    +             R  S ++   S S  W S D   V+  
Sbjct: 147 PVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQ 206

Query: 247 WFRQPQSNWGIEINAF---DPSGTDLAVTSLG--PGAEG----LH----PFMELRVLE-- 291
           W  +     G  ++A    D     L V   G   G  G    +H    PF+ L      
Sbjct: 207 WLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLE 266

Query: 292 -----NTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEA-FGWDWIIAPKRYKANYCSGQC 345
                 + R RR L  +    S+E  CC   L +DF    GW WI  PK Y AN+C G C
Sbjct: 267 RAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPC 326

Query: 346 EYMFMQKYPHTH---LVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVD 402
            Y++     ++    L  Q NP  SA PCC P  + P+ ++Y+  ++  +  ++  M+V 
Sbjct: 327 PYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKV-EQLSNMIVR 385

Query: 403 RCGCS 407
            C CS
Sbjct: 386 SCKCS 390


>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
           sapiens]
          Length = 454

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 64/207 (30%), Positives = 88/207 (42%), Gaps = 35/207 (16%)

Query: 235 WQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLG----PGAEGLHPFM----- 285
           W   D     + W   PQ+N G+++ A    G  + V S G     G +   PFM     
Sbjct: 247 WLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFK 306

Query: 286 -------ELRVLENTKRSRRN----------LGLDCDEHSSESR--CCRYPLTVDFEAFG 326
                   +R     K   RN          +    D ++SE +  C ++ L V F   G
Sbjct: 307 ASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLG 366

Query: 327 W-DWIIAPKRYKANYCSGQCEYMFMQKYPHTH------LVQQANPRGSAGPCCTPTKMSP 379
           W DWIIAP+ Y A YC G+C +        T+      LV    P     PCC PTK++ 
Sbjct: 367 WQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNA 426

Query: 380 INMLYFNDKQQIIYGKIPGMVVDRCGC 406
           I++LYF+D   +I  K   MVV  CGC
Sbjct: 427 ISVLYFDDSSNVILKKYRNMVVRSCGC 453


>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
           sapiens]
          Length = 424

 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 55/142 (38%), Positives = 72/142 (50%), Gaps = 17/142 (11%)

Query: 273 SLGPGAEGLHPFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAFGWD-WII 331
           S GPG E L       + ++T R RRN        +  + C R PL +DF+  GWD WII
Sbjct: 291 SSGPGEEALLQMRSNIIYDSTARIRRN--------AKGNYCKRTPLYIDFKEIGWDSWII 342

Query: 332 APKRYKANYCSGQCEYMFMQKY-PHTHLVQQA-----NPRGSAGPCCTPTKMSPINMLYF 385
           AP  Y+A  C G C Y   +   P  H + QA     N + ++  CC PTK+ PI++LY 
Sbjct: 343 APPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYL 402

Query: 386 NDKQQIIYG-KIPGMVVDRCGC 406
            DK  + Y  K  GM V  CGC
Sbjct: 403 -DKGVVTYKFKYEGMAVSECGC 423


>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
          Length = 431

 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 60/208 (28%), Positives = 87/208 (41%), Gaps = 36/208 (17%)

Query: 235 WQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLG----PGAEGLHPFM----- 285
           W   D     + W   P+ N G++++     G  +     G     G +   PFM     
Sbjct: 223 WLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFK 282

Query: 286 ----ELRVLENTKRSRRNLGLD--------------CDEHSSESR--CCRYPLTVDFEAF 325
                 R + +T   +R+                   +  SS+ R  C ++ L V F   
Sbjct: 283 ATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDL 342

Query: 326 GW-DWIIAPKRYKANYCSGQCEY---MFMQKYPHT---HLVQQANPRGSAGPCCTPTKMS 378
           GW DWIIAP+ Y A YC G+C +    +M    H     LV   NP     PCC PT+++
Sbjct: 343 GWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLN 402

Query: 379 PINMLYFNDKQQIIYGKIPGMVVDRCGC 406
            I++LYF+D   +I  K   MVV  CGC
Sbjct: 403 AISVLYFDDSSNVILKKYRNMVVRACGC 430


>gi|61835232 growth differentiation factor 7 preproprotein [Homo
           sapiens]
          Length = 450

 Score = 85.5 bits (210), Expect = 8e-17
 Identities = 40/103 (38%), Positives = 57/103 (55%), Gaps = 7/103 (6%)

Query: 311 SRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEYMFMQKYPHTH------LVQQAN 363
           SRC R PL VDF+  GWD WIIAP  Y+A +C G C++        T+      L+    
Sbjct: 347 SRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMA 406

Query: 364 PRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406
           P  +   CC P ++SPI++LY +    ++Y +   MVV+ CGC
Sbjct: 407 PDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGC 449


>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 64/218 (29%), Positives = 95/218 (43%), Gaps = 33/218 (15%)

Query: 218 HIRIRSLKIEL-HSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFD------PSGTDLA 270
           H+  R L   L H     W++ D    +  W R+ Q N+G+ I            G  + 
Sbjct: 194 HLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVR 253

Query: 271 VTSLGPGAEG----LHPFMEL-------RVLENTKRSRRNLGLDCDEHSSESR-----CC 314
           ++   P   G    L P +           L   +R++R+       HS  +R     C 
Sbjct: 254 ISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSP----KHHSQRARKKNKNCR 309

Query: 315 RYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMFMQKYPHT-HLVQQA--NPRGSAGP 370
           R+ L VDF   GW DWI+AP  Y+A YC G C +        T H + Q   N   S+ P
Sbjct: 310 RHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIP 369

Query: 371 --CCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406
             CC PT++S I+MLY ++  +++      MVV+ CGC
Sbjct: 370 KACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407


>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 64/218 (29%), Positives = 95/218 (43%), Gaps = 33/218 (15%)

Query: 218 HIRIRSLKIEL-HSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFD------PSGTDLA 270
           H+  R L   L H     W++ D    +  W R+ Q N+G+ I            G  + 
Sbjct: 194 HLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVR 253

Query: 271 VTSLGPGAEG----LHPFMEL-------RVLENTKRSRRNLGLDCDEHSSESR-----CC 314
           ++   P   G    L P +           L   +R++R+       HS  +R     C 
Sbjct: 254 ISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSP----KHHSQRARKKNKNCR 309

Query: 315 RYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMFMQKYPHT-HLVQQA--NPRGSAGP 370
           R+ L VDF   GW DWI+AP  Y+A YC G C +        T H + Q   N   S+ P
Sbjct: 310 RHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIP 369

Query: 371 --CCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406
             CC PT++S I+MLY ++  +++      MVV+ CGC
Sbjct: 370 KACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407


>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 64/218 (29%), Positives = 95/218 (43%), Gaps = 33/218 (15%)

Query: 218 HIRIRSLKIEL-HSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFD------PSGTDLA 270
           H+  R L   L H     W++ D    +  W R+ Q N+G+ I            G  + 
Sbjct: 194 HLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVR 253

Query: 271 VTSLGPGAEG----LHPFMEL-------RVLENTKRSRRNLGLDCDEHSSESR-----CC 314
           ++   P   G    L P +           L   +R++R+       HS  +R     C 
Sbjct: 254 ISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSP----KHHSQRARKKNKNCR 309

Query: 315 RYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMFMQKYPHT-HLVQQA--NPRGSAGP 370
           R+ L VDF   GW DWI+AP  Y+A YC G C +        T H + Q   N   S+ P
Sbjct: 310 RHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIP 369

Query: 371 --CCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406
             CC PT++S I+MLY ++  +++      MVV+ CGC
Sbjct: 370 KACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407


>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
           sapiens]
          Length = 396

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 91/364 (25%), Positives = 145/364 (39%), Gaps = 51/364 (14%)

Query: 76  LESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDL---HDFQGDALQPEDFLEE 132
           L   + ++LS   LK+ P  SR+ V       PP   +LDL   H  Q  +  P+  LE 
Sbjct: 50  LSEFELRLLSMFGLKQRPTPSRDAV------VPPY--MLDLYRRHSGQPGSPAPDHRLER 101

Query: 133 DEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTK--VLKAQLWVYLRPVPRP 190
               A T       +  +   +T G      F F+   + T+  +  A+L V+   +   
Sbjct: 102 AASRANTVRSFHHEESLEELPETSGKTTR-RFFFNLSSIPTEEFITSAELQVFREQMQDA 160

Query: 191 A---TVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSW 247
               + +   + +  +    TA       R +  R +    +  +  W+S D    +  W
Sbjct: 161 LGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLV----NQNASRWESFDVTPAVMRW 216

Query: 248 FRQPQSNWGIEINAF---DPSGTDLAVTSLGPGA-EGLHPFMELRVLENT---------- 293
             Q  +N G  +      +  G       +     +  H + ++R L  T          
Sbjct: 217 TAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPL 276

Query: 294 -KRSRRNLGLDCDEHSSESR----CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEY 347
            KR +R       +H    R    C R+PL VDF   GW DWI+AP  Y A YC G+C +
Sbjct: 277 HKREKRQA-----KHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPF 331

Query: 348 MFMQKYPHT-HLVQQA--NPRGSAGP--CCTPTKMSPINMLYFNDKQQIIYGKIPGMVVD 402
                   T H + Q   N   S  P  CC PT++S I+MLY ++ ++++      MVV+
Sbjct: 332 PLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVE 391

Query: 403 RCGC 406
            CGC
Sbjct: 392 GCGC 395


>gi|48475062 growth differentiation factor 6 precursor [Homo
           sapiens]
          Length = 455

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 39/105 (37%), Positives = 59/105 (56%), Gaps = 7/105 (6%)

Query: 309 SESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEYMFMQKYPHTH------LVQQ 361
           S  RC + PL V+F+  GWD WIIAP  Y+A +C G C++        T+      L+  
Sbjct: 350 SRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNS 409

Query: 362 ANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406
            +P  +   CC PTK++PI++LY +    ++Y +   MVV+ CGC
Sbjct: 410 MDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454


>gi|4503969 growth differentiation factor 5 preproprotein [Homo
           sapiens]
          Length = 501

 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 38/104 (36%), Positives = 59/104 (56%), Gaps = 7/104 (6%)

Query: 310 ESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEYMFMQKYPHTH------LVQQA 362
           ++RC R  L V+F+  GWD WIIAP  Y+A +C G CE+        T+      L+   
Sbjct: 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSM 456

Query: 363 NPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406
           +P  +   CC PT++SPI++L+ +    ++Y +   MVV+ CGC
Sbjct: 457 DPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGC 500


>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
           sapiens]
          Length = 402

 Score = 79.0 bits (193), Expect = 7e-15
 Identities = 45/121 (37%), Positives = 60/121 (49%), Gaps = 9/121 (7%)

Query: 295 RSRRNLGLDCDEHSSESR--CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMF-- 349
           ++ R  G+  D H S  R  C R+ L V F+  GW DW+IAP+ Y A YC G+C +    
Sbjct: 281 QANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDS 340

Query: 350 -MQKYPHT---HLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCG 405
            M    H     LV    P      CC PTK+S  ++LY++    +I  K   MVV  CG
Sbjct: 341 CMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACG 400

Query: 406 C 406
           C
Sbjct: 401 C 401


>gi|10190670 growth differentiation factor 3 precursor [Homo
           sapiens]
          Length = 364

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 45/122 (36%), Positives = 61/122 (50%), Gaps = 18/122 (14%)

Query: 297 RRNLGLDCDEHSSESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQC---------- 345
           +R   +   + S ++ C R+ L ++F   GW  WIIAPK + ANYC G+C          
Sbjct: 248 KRRAAIPVPKLSCKNLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNS 307

Query: 346 -EYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRC 404
             Y FMQ   H   V    P+      C PTK+SPI+MLY ++   +I      MVVD C
Sbjct: 308 SNYAFMQALMHA--VDPEIPQA----VCIPTKLSPISMLYQDNNDNVILRHYEDMVVDEC 361

Query: 405 GC 406
           GC
Sbjct: 362 GC 363


>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
           sapiens]
          Length = 472

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 38/102 (37%), Positives = 55/102 (53%), Gaps = 8/102 (7%)

Query: 313 CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMFMQKY-PHTHLVQQANPR----- 365
           C R  L VDF   GW +WII+PK + A YCSG C++   +   P  H   Q+  R     
Sbjct: 370 CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVV 429

Query: 366 -GSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406
            G   PCC P KMS +++L+F++ + ++    P M V+ C C
Sbjct: 430 PGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471


>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
          Length = 402

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 44/121 (36%), Positives = 59/121 (48%), Gaps = 9/121 (7%)

Query: 295 RSRRNLGLDCDEHSSESR--CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMF-- 349
           ++ R  G+  D   S  R  C R+ L V F+  GW DW+IAP+ Y A YC G+C +    
Sbjct: 281 QANRLPGIFDDVRGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDS 340

Query: 350 -MQKYPHT---HLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCG 405
            M    H     LV    P      CC PTK+S  ++LY++    +I  K   MVV  CG
Sbjct: 341 CMNATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACG 400

Query: 406 C 406
           C
Sbjct: 401 C 401


>gi|4826740 growth differentiation factor 10 precursor [Homo
           sapiens]
          Length = 478

 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 37/102 (36%), Positives = 53/102 (51%), Gaps = 8/102 (7%)

Query: 313 CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMFMQKY-PHTHLVQQANPR----- 365
           C R  L VDF   GW +WII+PK + A YC+G CE+   +   P  H   Q+  R     
Sbjct: 376 CSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGII 435

Query: 366 -GSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406
            G   PCC P KM+ + +L+ ++ + ++    P M VD C C
Sbjct: 436 PGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCAC 477


>gi|110349792 growth differentiation factor 1 [Homo sapiens]
          Length = 372

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 36/105 (34%), Positives = 52/105 (49%), Gaps = 11/105 (10%)

Query: 313 CCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEYMF----------MQKYPHTHLVQQ 361
           C    L V F   GW  W+IAP+ + ANYC GQC              +       L+  
Sbjct: 267 CRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHA 326

Query: 362 ANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406
           A P  +  PCC P ++SPI++L+F++   ++  +   MVVD CGC
Sbjct: 327 AAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371


>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
          Length = 392

 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 46/147 (31%), Positives = 66/147 (44%), Gaps = 27/147 (18%)

Query: 280 GLHPFMELRVLENTKRSRRNLGLDCDEHSSESR--------CCRYPLTVDFEAFGWD-WI 330
           G+  FME   L   +R+R+  G+  +  +S S+        C  +P  + F   GWD WI
Sbjct: 252 GMEEFMERESL--LRRTRQADGISAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWI 309

Query: 331 IAPKRYKANYCSGQC-----------EYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSP 379
           IAP  Y  NYC G C            +  +Q   +  LV Q+ PR    P C P K  P
Sbjct: 310 IAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLIN-QLVDQSVPR----PSCVPYKYVP 364

Query: 380 INMLYFNDKQQIIYGKIPGMVVDRCGC 406
           I++L       I+Y +  GM+ + C C
Sbjct: 365 ISVLMIEANGSILYKEYEGMIAESCTC 391


>gi|7705308 growth differentiation factor 2 [Homo sapiens]
          Length = 429

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 41/104 (39%), Positives = 50/104 (48%), Gaps = 8/104 (7%)

Query: 311 SRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEYMFMQKYPHTH------LVQQAN 363
           S C +  L V+FE  GWD WIIAPK Y+A  C G C +        T       LV    
Sbjct: 325 SHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKF 384

Query: 364 PRGSAGPCCTPTKMSPINMLYFNDK-QQIIYGKIPGMVVDRCGC 406
           P      CC PTK+SPI++LY +D     +     GM V  CGC
Sbjct: 385 PTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGC 428


>gi|222352098 nodal precursor [Homo sapiens]
          Length = 347

 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 33/101 (32%), Positives = 50/101 (49%), Gaps = 8/101 (7%)

Query: 313 CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMFMQKYPHTH------LVQQANPR 365
           C +    VDF   GW  WII PK+Y A  C G+C     +++  T+      L+++  P 
Sbjct: 247 CRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPH 306

Query: 366 GSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406
                CC P K  P++MLY  D  +++      M+V+ CGC
Sbjct: 307 RVPSTCCAPVKTKPLSMLYV-DNGRVLLDHHKDMIVEECGC 346


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.430 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,732,429
Number of Sequences: 37866
Number of extensions: 901502
Number of successful extensions: 9360
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 137
Number of HSP's successfully gapped in prelim test: 92
Number of HSP's that attempted gapping in prelim test: 7507
Number of HSP's gapped (non-prelim): 1251
length of query: 407
length of database: 18,247,518
effective HSP length: 105
effective length of query: 302
effective length of database: 14,271,588
effective search space: 4310019576
effective search space used: 4310019576
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.