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Search of human proteins with 5031601
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5031601 actin related protein 2/3 complex subunit 1B [Homo
sapiens]
(372 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5031601 actin related protein 2/3 complex subunit 1B [Homo sa... 775 0.0
gi|89026256 PREDICTED: similar to actin related protein 2/3 comp... 735 0.0
gi|22907052 actin related protein 2/3 complex subunit 1A [Homo s... 551 e-157
gi|4757988 WD repeat domain 39 [Homo sapiens] 65 1e-10
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 60 3e-09
gi|19913367 transducin beta-like 1Y [Homo sapiens] 55 1e-07
gi|19913365 transducin beta-like 1Y [Homo sapiens] 55 1e-07
gi|15150805 transducin beta-like 1Y [Homo sapiens] 55 1e-07
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 53 4e-07
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 53 4e-07
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 53 4e-07
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 53 4e-07
gi|210032390 SEC13 protein isoform 2 [Homo sapiens] 52 7e-07
gi|34335134 SEC13 protein isoform 1 [Homo sapiens] 52 7e-07
gi|21071067 TBP-associated factor 5 [Homo sapiens] 50 2e-06
gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens] 48 1e-05
gi|26665869 WD repeat domain 51B [Homo sapiens] 45 1e-04
gi|34996489 pleckstrin homology domain interacting protein [Homo... 44 2e-04
gi|46409657 WD repeat domain 56 [Homo sapiens] 43 4e-04
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 42 7e-04
gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo sapiens] 42 7e-04
gi|118402582 cell division cycle 20 [Homo sapiens] 42 9e-04
gi|46358428 selective LIM binding factor homolog [Homo sapiens] 42 9e-04
gi|55769546 PAK1 interacting protein 1 [Homo sapiens] 42 9e-04
gi|22749037 WD repeat domain 65 [Homo sapiens] 41 0.002
gi|58331266 WD repeat domain 59 [Homo sapiens] 41 0.002
gi|32189425 WD repeat domain 69 [Homo sapiens] 41 0.002
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 40 0.003
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 40 0.004
gi|186928847 cirhin [Homo sapiens] 40 0.004
>gi|5031601 actin related protein 2/3 complex subunit 1B [Homo
sapiens]
Length = 372
Score = 775 bits (2001), Expect = 0.0
Identities = 372/372 (100%), Positives = 372/372 (100%)
Query: 1 MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDW 60
MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDW
Sbjct: 1 MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDW 60
Query: 61 APESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVI 120
APESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVI
Sbjct: 61 APESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVI 120
Query: 121 SICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERP 180
SICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERP
Sbjct: 121 SICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERP 180
Query: 181 APTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATL 240
APTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATL
Sbjct: 181 APTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATL 240
Query: 241 ASETLPLLALTFITDNSLVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTARE 300
ASETLPLLALTFITDNSLVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTARE
Sbjct: 241 ASETLPLLALTFITDNSLVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTARE 300
Query: 301 RFQNLDKKASSEGGTAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVK 360
RFQNLDKKASSEGGTAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVK
Sbjct: 301 RFQNLDKKASSEGGTAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVK 360
Query: 361 SLESALKDLKIK 372
SLESALKDLKIK
Sbjct: 361 SLESALKDLKIK 372
>gi|89026256 PREDICTED: similar to actin related protein 2/3 complex
subunit 1B [Homo sapiens]
Length = 370
Score = 735 bits (1898), Expect = 0.0
Identities = 354/355 (99%), Positives = 355/355 (100%)
Query: 18 KDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAY 77
KDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAY
Sbjct: 16 KDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAY 75
Query: 78 VWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCKHI 137
VWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCKHI
Sbjct: 76 VWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCKHI 135
Query: 138 KKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFE 197
KKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFE
Sbjct: 136 KKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFE 195
Query: 198 SSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLALTFITDNS 257
SSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPL+ALTFITDNS
Sbjct: 196 SSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLVALTFITDNS 255
Query: 258 LVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGGTAA 317
LVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGGTAA
Sbjct: 256 LVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGGTAA 315
Query: 318 GAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVKSLESALKDLKIK 372
GAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVKSLESALKDLKIK
Sbjct: 316 GAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVKSLESALKDLKIK 370
>gi|22907052 actin related protein 2/3 complex subunit 1A [Homo
sapiens]
Length = 370
Score = 551 bits (1421), Expect = e-157
Identities = 254/373 (68%), Positives = 315/373 (84%), Gaps = 6/373 (1%)
Query: 1 MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDW 60
M+ H FL+EPI+CHAWN+DRTQIA+ PNNHEVHIY+K+G++W K HELKEHNG +TGIDW
Sbjct: 1 MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDW 60
Query: 61 APESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVI 120
AP+S+RIVTCG DRNAYVW+ K WKPTLVILRINRAA V+W+P ENKFAVGSG+R+I
Sbjct: 61 APKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLI 120
Query: 121 SICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERP 180
S+CYFE ENDWWV KHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCR+FSAYIKEV+E+P
Sbjct: 121 SVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKP 180
Query: 181 APTPWGSKMPFGELM--FESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVA 238
A TPWGSKMPFG+LM F S + GWVHGV FSASGSR+AWVSHDSTV +ADA K + V+
Sbjct: 181 ASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVS 240
Query: 239 TLASETLPLLALTFITDNSLVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTA 298
TL +E LPLL+++F+++NS+VAAGHDC P+LF YD G L+F +LD+PKQS QR ++A
Sbjct: 241 TLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYD-DRGCLTFVSKLDIPKQSIQRNMSA 299
Query: 299 RERFQNLDKKASSEGGTAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWD 358
ERF+N+DK+A++E A L++LH+NS++Q+S+ K C +FCTTG+DG M+IWD
Sbjct: 300 MERFRNMDKRATTEDRNTA---LETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWD 356
Query: 359 VKSLESALKDLKI 371
K+LES+++ L+I
Sbjct: 357 FKTLESSIQGLRI 369
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 64.7 bits (156), Expect = 1e-10
Identities = 43/165 (26%), Positives = 76/165 (46%), Gaps = 3/165 (1%)
Query: 15 AWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDR 74
AW+ +A + I++K+ + V L+ H +V + WAP N + TC D+
Sbjct: 68 AWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDK 127
Query: 75 NAYVWTLKGRTWKPTLVILRIN-RAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWV 133
+ +VW + + +L + + + V W P++ A S + + + +E D WV
Sbjct: 128 SVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL--YREEEDDWV 185
Query: 134 CKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEE 178
C + STV SL + P+ LA+ S D RI+ Y+ E+
Sbjct: 186 CCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQ 230
Score = 63.2 bits (152), Expect = 4e-10
Identities = 51/213 (23%), Positives = 80/213 (37%), Gaps = 18/213 (8%)
Query: 15 AWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKE-HNGQVTGIDWAPESNRIVTCGTD 73
AWN T +A C + + I+ G W L E H V + W+P N + + D
Sbjct: 23 AWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFD 82
Query: 74 RNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWV 133
+W ++ + + V WAP+ N A S + + + ++E D +
Sbjct: 83 ATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEE-DEYE 141
Query: 134 CKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGE 193
C + V + WHP+ LLA+ S D +++ R W
Sbjct: 142 CVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY---------REEEDDWVCC----- 187
Query: 194 LMFESSSSCGWVHGVCFSASGSRVAWVSHDSTV 226
E S W + F SG R+A S D TV
Sbjct: 188 ATLEGHESTVW--SLAFDPSGQRLASCSDDRTV 218
Score = 50.4 bits (119), Expect = 2e-06
Identities = 54/208 (25%), Positives = 84/208 (40%), Gaps = 20/208 (9%)
Query: 60 WAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILR-INRAARCVRWAPNENKFAVGSGSR 118
W P + +CG DR +W +G +W V+ R R V W+P N A S S
Sbjct: 24 WNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLA--SASF 81
Query: 119 VISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEE 178
+ C +++ D + C + + V S+ W P+ LLA S D S ++ EV+E
Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRD-----KSVWVWEVDE 136
Query: 179 RPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCL--ADADKKMA 236
E + +S V V + S +A S+D TV L + D +
Sbjct: 137 EDE----------YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVC 186
Query: 237 VATLASETLPLLALTFITDNSLVAAGHD 264
ATL + +L F +A+ D
Sbjct: 187 CATLEGHESTVWSLAFDPSGQRLASCSD 214
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 60.1 bits (144), Expect = 3e-09
Identities = 65/265 (24%), Positives = 103/265 (38%), Gaps = 55/265 (20%)
Query: 16 WNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRN 75
WN + T +A + I+ K G L +H G + + W + N I++ G D+
Sbjct: 233 WNSEGTLLATGSYDGFARIWTKDG---NLASTLGQHKGPIFALKWNKKGNFILSAGVDKT 289
Query: 76 AYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCK 135
+W T + + A V W N N FA S I +C Q+
Sbjct: 290 TIIWD--AHTGEAKQQFPFHSAPALDVDWQSN-NTFASCSTDMCIHVCKLGQD------- 339
Query: 136 HIKKPIRS------TVLSLDWHPNNVLLAAGSCDFKCRIFS-----------AYIKEVEE 178
+PI++ V ++ W P LLA+ S D +I+S A+ KE+
Sbjct: 340 ---RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYT 396
Query: 179 -RPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAV 237
+ +PT G+ P LM S+S DSTV L D D+ + +
Sbjct: 397 IKWSPTGPGTNNPNANLMLASAS---------------------FDSTVRLWDVDRGICI 435
Query: 238 ATLASETLPLLALTFITDNSLVAAG 262
TL P+ ++ F D +A+G
Sbjct: 436 HTLTKHQEPVYSVAFSPDGRYLASG 460
Score = 53.1 bits (126), Expect = 4e-07
Identities = 47/223 (21%), Positives = 88/223 (39%), Gaps = 29/223 (13%)
Query: 16 WNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRN 75
W + T A C + +H+ + + K + H +V I W P N + +C D
Sbjct: 316 WQSNNT-FASCSTDMCIHVCKLGQDRPIKTFQ--GHTNEVNAIKWDPTGNLLASCSDDMT 372
Query: 76 AYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWW--- 132
+W++K L N+ ++W+P + + +++ F+ W
Sbjct: 373 LKIWSMKQDNCVHDL--QAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVD 430
Query: 133 --VCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMP 190
+C H + V S+ + P+ LA+GS D I++ T G+
Sbjct: 431 RGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN------------TQTGA--- 475
Query: 191 FGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADK 233
+ S G + VC++A+G +V + D +VC+ D K
Sbjct: 476 ----LVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK 514
Score = 33.1 bits (74), Expect = 0.41
Identities = 32/118 (27%), Positives = 45/118 (38%), Gaps = 15/118 (12%)
Query: 54 QVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVR-WAPNENKFA 112
+V G P + +V G + ++ W P +L R W +EN +
Sbjct: 150 EVDGDVEIPPNKAVVLRGHESEVFICA-----WNPVSDLLASGSGDSTARIWNLSENSTS 204
Query: 113 VGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFS 170
GS V+ C E D P V SLDW+ LLA GS D RI++
Sbjct: 205 -GSTQLVLRHCIREGGQD--------VPSNKDVTSLDWNSEGTLLATGSYDGFARIWT 253
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 54.7 bits (130), Expect = 1e-07
Identities = 60/262 (22%), Positives = 102/262 (38%), Gaps = 49/262 (18%)
Query: 16 WNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRN 75
WN D T +A+ + I+ ++G L +H G + + W + N +++ G D+
Sbjct: 243 WNSDGTLLAMGSYDGFARIWTENG---NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKT 299
Query: 76 AYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCK 135
+W T + + A V W N FA S I +C C
Sbjct: 300 TIIW--DAHTGEAKQQFPFHSAPALDVDW-QNNMTFASCSTDMCIHVCRLG-------CD 349
Query: 136 HIKKPIR---STVLSLDWHPNNVLLAAGSCDFKCRIFS-----------AYIKEVEE-RP 180
H K + + V ++ W P+ +LLA+ S D +I+S A+ KE+ +
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKW 409
Query: 181 APTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATL 240
+PT + P +M S+ S DSTV L D ++ + TL
Sbjct: 410 SPTGPATSNPNSSIMLASA---------------------SFDSTVRLWDVEQGVCTHTL 448
Query: 241 ASETLPLLALTFITDNSLVAAG 262
P+ ++ F D +A+G
Sbjct: 449 MKHQEPVYSVAFSPDGKYLASG 470
Score = 50.8 bits (120), Expect = 2e-06
Identities = 42/191 (21%), Positives = 75/191 (39%), Gaps = 26/191 (13%)
Query: 45 VHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRW 104
V + H +V I W P + +C D +W++K L ++ ++W
Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDL--QAHSKEIYTIKW 409
Query: 105 APNENKFAVGSGSRVISICYFEQENDWW-----VCKHIKKPIRSTVLSLDWHPNNVLLAA 159
+P + + S +++ F+ W VC H + V S+ + P+ LA+
Sbjct: 410 SPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLAS 469
Query: 160 GSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAW 219
GS D I++ T GS + S G + VC++A G +V
Sbjct: 470 GSFDKYVHIWN------------TQSGS-------LVHSYQGTGGIFEVCWNARGDKVGA 510
Query: 220 VSHDSTVCLAD 230
+ D +VC+ D
Sbjct: 511 SASDGSVCVLD 521
Score = 38.5 bits (88), Expect = 0.010
Identities = 41/148 (27%), Positives = 59/148 (39%), Gaps = 23/148 (15%)
Query: 27 PNNHEVHIY-EKSGAKWTKVHELKEHNG--QVTGIDWAPESNRIVTCGTDRNAYVWTLKG 83
P N E + E++GA HE+ H+ ++ G P + V G + ++
Sbjct: 135 PKNREATVNGEENGA-----HEINNHSKPMEIDGDVEIPPNKATVLRGHESEVFICA--- 186
Query: 84 RTWKPTLVILRINRAARCVR-WAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIR 142
W P +L R W NEN GS V+ C E +D P
Sbjct: 187 --WNPVSDLLASGSGDSTARIWNLNENSNG-GSTQLVLRHCIREGGHD--------VPSN 235
Query: 143 STVLSLDWHPNNVLLAAGSCDFKCRIFS 170
V SLDW+ + LLA GS D RI++
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIWT 263
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 54.7 bits (130), Expect = 1e-07
Identities = 60/262 (22%), Positives = 102/262 (38%), Gaps = 49/262 (18%)
Query: 16 WNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRN 75
WN D T +A+ + I+ ++G L +H G + + W + N +++ G D+
Sbjct: 243 WNSDGTLLAMGSYDGFARIWTENG---NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKT 299
Query: 76 AYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCK 135
+W T + + A V W N FA S I +C C
Sbjct: 300 TIIW--DAHTGEAKQQFPFHSAPALDVDW-QNNMTFASCSTDMCIHVCRLG-------CD 349
Query: 136 HIKKPIR---STVLSLDWHPNNVLLAAGSCDFKCRIFS-----------AYIKEVEE-RP 180
H K + + V ++ W P+ +LLA+ S D +I+S A+ KE+ +
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKW 409
Query: 181 APTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATL 240
+PT + P +M S+ S DSTV L D ++ + TL
Sbjct: 410 SPTGPATSNPNSSIMLASA---------------------SFDSTVRLWDVEQGVCTHTL 448
Query: 241 ASETLPLLALTFITDNSLVAAG 262
P+ ++ F D +A+G
Sbjct: 449 MKHQEPVYSVAFSPDGKYLASG 470
Score = 50.8 bits (120), Expect = 2e-06
Identities = 42/191 (21%), Positives = 75/191 (39%), Gaps = 26/191 (13%)
Query: 45 VHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRW 104
V + H +V I W P + +C D +W++K L ++ ++W
Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDL--QAHSKEIYTIKW 409
Query: 105 APNENKFAVGSGSRVISICYFEQENDWW-----VCKHIKKPIRSTVLSLDWHPNNVLLAA 159
+P + + S +++ F+ W VC H + V S+ + P+ LA+
Sbjct: 410 SPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLAS 469
Query: 160 GSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAW 219
GS D I++ T GS + S G + VC++A G +V
Sbjct: 470 GSFDKYVHIWN------------TQSGS-------LVHSYQGTGGIFEVCWNARGDKVGA 510
Query: 220 VSHDSTVCLAD 230
+ D +VC+ D
Sbjct: 511 SASDGSVCVLD 521
Score = 38.5 bits (88), Expect = 0.010
Identities = 41/148 (27%), Positives = 59/148 (39%), Gaps = 23/148 (15%)
Query: 27 PNNHEVHIY-EKSGAKWTKVHELKEHNG--QVTGIDWAPESNRIVTCGTDRNAYVWTLKG 83
P N E + E++GA HE+ H+ ++ G P + V G + ++
Sbjct: 135 PKNREATVNGEENGA-----HEINNHSKPMEIDGDVEIPPNKATVLRGHESEVFICA--- 186
Query: 84 RTWKPTLVILRINRAARCVR-WAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIR 142
W P +L R W NEN GS V+ C E +D P
Sbjct: 187 --WNPVSDLLASGSGDSTARIWNLNENSNG-GSTQLVLRHCIREGGHD--------VPSN 235
Query: 143 STVLSLDWHPNNVLLAAGSCDFKCRIFS 170
V SLDW+ + LLA GS D RI++
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIWT 263
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 54.7 bits (130), Expect = 1e-07
Identities = 60/262 (22%), Positives = 102/262 (38%), Gaps = 49/262 (18%)
Query: 16 WNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRN 75
WN D T +A+ + I+ ++G L +H G + + W + N +++ G D+
Sbjct: 243 WNSDGTLLAMGSYDGFARIWTENG---NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKT 299
Query: 76 AYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCK 135
+W T + + A V W N FA S I +C C
Sbjct: 300 TIIW--DAHTGEAKQQFPFHSAPALDVDW-QNNMTFASCSTDMCIHVCRLG-------CD 349
Query: 136 HIKKPIR---STVLSLDWHPNNVLLAAGSCDFKCRIFS-----------AYIKEVEE-RP 180
H K + + V ++ W P+ +LLA+ S D +I+S A+ KE+ +
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKW 409
Query: 181 APTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATL 240
+PT + P +M S+ S DSTV L D ++ + TL
Sbjct: 410 SPTGPATSNPNSSIMLASA---------------------SFDSTVRLWDVEQGVCTHTL 448
Query: 241 ASETLPLLALTFITDNSLVAAG 262
P+ ++ F D +A+G
Sbjct: 449 MKHQEPVYSVAFSPDGKYLASG 470
Score = 50.8 bits (120), Expect = 2e-06
Identities = 42/191 (21%), Positives = 75/191 (39%), Gaps = 26/191 (13%)
Query: 45 VHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRW 104
V + H +V I W P + +C D +W++K L ++ ++W
Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDL--QAHSKEIYTIKW 409
Query: 105 APNENKFAVGSGSRVISICYFEQENDWW-----VCKHIKKPIRSTVLSLDWHPNNVLLAA 159
+P + + S +++ F+ W VC H + V S+ + P+ LA+
Sbjct: 410 SPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLAS 469
Query: 160 GSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAW 219
GS D I++ T GS + S G + VC++A G +V
Sbjct: 470 GSFDKYVHIWN------------TQSGS-------LVHSYQGTGGIFEVCWNARGDKVGA 510
Query: 220 VSHDSTVCLAD 230
+ D +VC+ D
Sbjct: 511 SASDGSVCVLD 521
Score = 38.5 bits (88), Expect = 0.010
Identities = 41/148 (27%), Positives = 59/148 (39%), Gaps = 23/148 (15%)
Query: 27 PNNHEVHIY-EKSGAKWTKVHELKEHNG--QVTGIDWAPESNRIVTCGTDRNAYVWTLKG 83
P N E + E++GA HE+ H+ ++ G P + V G + ++
Sbjct: 135 PKNREATVNGEENGA-----HEINNHSKPMEIDGDVEIPPNKATVLRGHESEVFICA--- 186
Query: 84 RTWKPTLVILRINRAARCVR-WAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIR 142
W P +L R W NEN GS V+ C E +D P
Sbjct: 187 --WNPVSDLLASGSGDSTARIWNLNENSNG-GSTQLVLRHCIREGGHD--------VPSN 235
Query: 143 STVLSLDWHPNNVLLAAGSCDFKCRIFS 170
V SLDW+ + LLA GS D RI++
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIWT 263
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 53.1 bits (126), Expect = 4e-07
Identities = 49/221 (22%), Positives = 89/221 (40%), Gaps = 28/221 (12%)
Query: 18 KDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAY 77
++ T A C + +H+ + K + H +V I W P + +C D
Sbjct: 329 QNNTTFASCSTDMCIHVCRLGCDRPVKTFQ--GHTNEVNAIKWDPSGMLLASCSDDMTLK 386
Query: 78 VWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWW----- 132
+W++K L N+ ++W+P + + + +++ F+ W
Sbjct: 387 IWSMKQEVCIHDL--QAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG 444
Query: 133 VCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFG 192
VC H + V S+ + P+ LA+GS D KC +I W ++ G
Sbjct: 445 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFD-KC----VHI-----------WNTQS--G 486
Query: 193 ELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADK 233
L+ S G + VC++A G +V + D +VC+ D K
Sbjct: 487 NLV-HSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 526
Score = 48.9 bits (115), Expect = 7e-06
Identities = 59/262 (22%), Positives = 99/262 (37%), Gaps = 49/262 (18%)
Query: 16 WNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRN 75
WN + T +A + I+ + G L +H G + + W + N I++ G D+
Sbjct: 245 WNTNGTLLATGSYDGFARIWTEDG---NLASTLGQHKGPIFALKWNRKGNYILSAGVDKT 301
Query: 76 AYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCK 135
+W T + + A V W N FA S I +C C
Sbjct: 302 TIIW--DAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLG-------CD 351
Query: 136 HIKKPIR---STVLSLDWHPNNVLLAAGSCDFKCRIFS-----------AYIKEVEE-RP 180
K + + V ++ W P+ +LLA+ S D +I+S A+ KE+ +
Sbjct: 352 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKW 411
Query: 181 APTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATL 240
+PT + P +M S+ S DSTV L D ++ + TL
Sbjct: 412 SPTGPATSNPNSNIMLASA---------------------SFDSTVRLWDIERGVCTHTL 450
Query: 241 ASETLPLLALTFITDNSLVAAG 262
P+ ++ F D +A+G
Sbjct: 451 TKHQEPVYSVAFSPDGKYLASG 472
Score = 37.7 bits (86), Expect = 0.017
Identities = 35/128 (27%), Positives = 47/128 (36%), Gaps = 34/128 (26%)
Query: 43 TKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCV 102
+K L+ H +V W P S+ + + D A +W L
Sbjct: 172 SKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNL--------------------- 210
Query: 103 RWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSC 162
NEN GS V+ C E +D P V SLDW+ N LLA GS
Sbjct: 211 ----NENSNG-GSTQLVLRHCIREGGHD--------VPSNKDVTSLDWNTNGTLLATGSY 257
Query: 163 DFKCRIFS 170
D RI++
Sbjct: 258 DGFARIWT 265
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 53.1 bits (126), Expect = 4e-07
Identities = 49/221 (22%), Positives = 89/221 (40%), Gaps = 28/221 (12%)
Query: 18 KDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAY 77
++ T A C + +H+ + K + H +V I W P + +C D
Sbjct: 329 QNNTTFASCSTDMCIHVCRLGCDRPVKTFQ--GHTNEVNAIKWDPSGMLLASCSDDMTLK 386
Query: 78 VWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWW----- 132
+W++K L N+ ++W+P + + + +++ F+ W
Sbjct: 387 IWSMKQEVCIHDL--QAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG 444
Query: 133 VCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFG 192
VC H + V S+ + P+ LA+GS D KC +I W ++ G
Sbjct: 445 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFD-KC----VHI-----------WNTQS--G 486
Query: 193 ELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADK 233
L+ S G + VC++A G +V + D +VC+ D K
Sbjct: 487 NLV-HSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 526
Score = 48.9 bits (115), Expect = 7e-06
Identities = 59/262 (22%), Positives = 99/262 (37%), Gaps = 49/262 (18%)
Query: 16 WNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRN 75
WN + T +A + I+ + G L +H G + + W + N I++ G D+
Sbjct: 245 WNTNGTLLATGSYDGFARIWTEDG---NLASTLGQHKGPIFALKWNRKGNYILSAGVDKT 301
Query: 76 AYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCK 135
+W T + + A V W N FA S I +C C
Sbjct: 302 TIIW--DAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLG-------CD 351
Query: 136 HIKKPIR---STVLSLDWHPNNVLLAAGSCDFKCRIFS-----------AYIKEVEE-RP 180
K + + V ++ W P+ +LLA+ S D +I+S A+ KE+ +
Sbjct: 352 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKW 411
Query: 181 APTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATL 240
+PT + P +M S+ S DSTV L D ++ + TL
Sbjct: 412 SPTGPATSNPNSNIMLASA---------------------SFDSTVRLWDIERGVCTHTL 450
Query: 241 ASETLPLLALTFITDNSLVAAG 262
P+ ++ F D +A+G
Sbjct: 451 TKHQEPVYSVAFSPDGKYLASG 472
Score = 37.7 bits (86), Expect = 0.017
Identities = 35/128 (27%), Positives = 47/128 (36%), Gaps = 34/128 (26%)
Query: 43 TKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCV 102
+K L+ H +V W P S+ + + D A +W L
Sbjct: 172 SKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNL--------------------- 210
Query: 103 RWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSC 162
NEN GS V+ C E +D P V SLDW+ N LLA GS
Sbjct: 211 ----NENSNG-GSTQLVLRHCIREGGHD--------VPSNKDVTSLDWNTNGTLLATGSY 257
Query: 163 DFKCRIFS 170
D RI++
Sbjct: 258 DGFARIWT 265
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 53.1 bits (126), Expect = 4e-07
Identities = 49/221 (22%), Positives = 89/221 (40%), Gaps = 28/221 (12%)
Query: 18 KDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAY 77
++ T A C + +H+ + K + H +V I W P + +C D
Sbjct: 380 QNNTTFASCSTDMCIHVCRLGCDRPVKTFQ--GHTNEVNAIKWDPSGMLLASCSDDMTLK 437
Query: 78 VWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWW----- 132
+W++K L N+ ++W+P + + + +++ F+ W
Sbjct: 438 IWSMKQEVCIHDL--QAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG 495
Query: 133 VCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFG 192
VC H + V S+ + P+ LA+GS D KC +I W ++ G
Sbjct: 496 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFD-KC----VHI-----------WNTQS--G 537
Query: 193 ELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADK 233
L+ S G + VC++A G +V + D +VC+ D K
Sbjct: 538 NLV-HSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577
Score = 48.9 bits (115), Expect = 7e-06
Identities = 59/262 (22%), Positives = 99/262 (37%), Gaps = 49/262 (18%)
Query: 16 WNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRN 75
WN + T +A + I+ + G L +H G + + W + N I++ G D+
Sbjct: 296 WNTNGTLLATGSYDGFARIWTEDG---NLASTLGQHKGPIFALKWNRKGNYILSAGVDKT 352
Query: 76 AYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCK 135
+W T + + A V W N FA S I +C C
Sbjct: 353 TIIW--DAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLG-------CD 402
Query: 136 HIKKPIR---STVLSLDWHPNNVLLAAGSCDFKCRIFS-----------AYIKEVEE-RP 180
K + + V ++ W P+ +LLA+ S D +I+S A+ KE+ +
Sbjct: 403 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKW 462
Query: 181 APTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATL 240
+PT + P +M S+ S DSTV L D ++ + TL
Sbjct: 463 SPTGPATSNPNSNIMLASA---------------------SFDSTVRLWDIERGVCTHTL 501
Query: 241 ASETLPLLALTFITDNSLVAAG 262
P+ ++ F D +A+G
Sbjct: 502 TKHQEPVYSVAFSPDGKYLASG 523
Score = 37.7 bits (86), Expect = 0.017
Identities = 35/128 (27%), Positives = 47/128 (36%), Gaps = 34/128 (26%)
Query: 43 TKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCV 102
+K L+ H +V W P S+ + + D A +W L
Sbjct: 223 SKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNL--------------------- 261
Query: 103 RWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSC 162
NEN GS V+ C E +D P V SLDW+ N LLA GS
Sbjct: 262 ----NENSNG-GSTQLVLRHCIREGGHD--------VPSNKDVTSLDWNTNGTLLATGSY 308
Query: 163 DFKCRIFS 170
D RI++
Sbjct: 309 DGFARIWT 316
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 53.1 bits (126), Expect = 4e-07
Identities = 49/221 (22%), Positives = 89/221 (40%), Gaps = 28/221 (12%)
Query: 18 KDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAY 77
++ T A C + +H+ + K + H +V I W P + +C D
Sbjct: 380 QNNTTFASCSTDMCIHVCRLGCDRPVKTFQ--GHTNEVNAIKWDPSGMLLASCSDDMTLK 437
Query: 78 VWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWW----- 132
+W++K L N+ ++W+P + + + +++ F+ W
Sbjct: 438 IWSMKQEVCIHDL--QAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG 495
Query: 133 VCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFG 192
VC H + V S+ + P+ LA+GS D KC +I W ++ G
Sbjct: 496 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFD-KC----VHI-----------WNTQS--G 537
Query: 193 ELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADK 233
L+ S G + VC++A G +V + D +VC+ D K
Sbjct: 538 NLV-HSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577
Score = 48.9 bits (115), Expect = 7e-06
Identities = 59/262 (22%), Positives = 99/262 (37%), Gaps = 49/262 (18%)
Query: 16 WNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRN 75
WN + T +A + I+ + G L +H G + + W + N I++ G D+
Sbjct: 296 WNTNGTLLATGSYDGFARIWTEDG---NLASTLGQHKGPIFALKWNRKGNYILSAGVDKT 352
Query: 76 AYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCK 135
+W T + + A V W N FA S I +C C
Sbjct: 353 TIIW--DAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLG-------CD 402
Query: 136 HIKKPIR---STVLSLDWHPNNVLLAAGSCDFKCRIFS-----------AYIKEVEE-RP 180
K + + V ++ W P+ +LLA+ S D +I+S A+ KE+ +
Sbjct: 403 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKW 462
Query: 181 APTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATL 240
+PT + P +M S+ S DSTV L D ++ + TL
Sbjct: 463 SPTGPATSNPNSNIMLASA---------------------SFDSTVRLWDIERGVCTHTL 501
Query: 241 ASETLPLLALTFITDNSLVAAG 262
P+ ++ F D +A+G
Sbjct: 502 TKHQEPVYSVAFSPDGKYLASG 523
Score = 37.7 bits (86), Expect = 0.017
Identities = 35/128 (27%), Positives = 47/128 (36%), Gaps = 34/128 (26%)
Query: 43 TKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCV 102
+K L+ H +V W P S+ + + D A +W L
Sbjct: 223 SKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNL--------------------- 261
Query: 103 RWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSC 162
NEN GS V+ C E +D P V SLDW+ N LLA GS
Sbjct: 262 ----NENSNG-GSTQLVLRHCIREGGHD--------VPSNKDVTSLDWNTNGTLLATGSY 308
Query: 163 DFKCRIFS 170
D RI++
Sbjct: 309 DGFARIWT 316
>gi|210032390 SEC13 protein isoform 2 [Homo sapiens]
Length = 308
Score = 52.4 bits (124), Expect = 7e-07
Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 4/119 (3%)
Query: 21 TQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPE--SNRIVTCGTDRNAYV 78
T++A C ++ V I++ + +L+ H G V + WA N + +C DR +
Sbjct: 12 TRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVII 71
Query: 79 WTLKGRTWKPTLVILRINRAARCVRWAPNENK--FAVGSGSRVISICYFEQENDWWVCK 135
W + TW+ + + + V WAP++ A GS IS+ + E W V K
Sbjct: 72 WREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 130
Score = 50.1 bits (118), Expect = 3e-06
Identities = 28/106 (26%), Positives = 48/106 (45%), Gaps = 9/106 (8%)
Query: 36 EKSGAKWTKVHELKEHNGQVTGIDWAPE----SNRIVTCGTDRNAYVWT---LKGRTWKP 88
E+ +W + +L+ H+ V + WAP ++ I +C D ++WT TW P
Sbjct: 182 EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSP 241
Query: 89 TLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVC 134
L + + N V W+ N AV G +++ + E + WVC
Sbjct: 242 KL-LHKFNDVVWHVSWSITANILAVSGGDNKVTL-WKESVDGQWVC 285
Score = 40.4 bits (93), Expect = 0.003
Identities = 32/131 (24%), Positives = 51/131 (38%), Gaps = 24/131 (18%)
Query: 23 IAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAP-ESNRIVTCGTDRNAYVWTL 81
+A C + +V I+ + W K HE H+ V + WAP + I+ CG+ A +L
Sbjct: 60 LASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAI--SL 117
Query: 82 KGRTWKPTLVILRINRA----ARCVRWAPNE-----------------NKFAVGSGSRVI 120
T + + +IN A V WAP +FA G +I
Sbjct: 118 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLI 177
Query: 121 SICYFEQENDW 131
+ E++ W
Sbjct: 178 KLWKEEEDGQW 188
>gi|34335134 SEC13 protein isoform 1 [Homo sapiens]
Length = 322
Score = 52.4 bits (124), Expect = 7e-07
Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 4/119 (3%)
Query: 21 TQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPE--SNRIVTCGTDRNAYV 78
T++A C ++ V I++ + +L+ H G V + WA N + +C DR +
Sbjct: 26 TRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVII 85
Query: 79 WTLKGRTWKPTLVILRINRAARCVRWAPNENK--FAVGSGSRVISICYFEQENDWWVCK 135
W + TW+ + + + V WAP++ A GS IS+ + E W V K
Sbjct: 86 WREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 144
Score = 50.1 bits (118), Expect = 3e-06
Identities = 28/106 (26%), Positives = 48/106 (45%), Gaps = 9/106 (8%)
Query: 36 EKSGAKWTKVHELKEHNGQVTGIDWAPE----SNRIVTCGTDRNAYVWT---LKGRTWKP 88
E+ +W + +L+ H+ V + WAP ++ I +C D ++WT TW P
Sbjct: 196 EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSP 255
Query: 89 TLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVC 134
L + + N V W+ N AV G +++ + E + WVC
Sbjct: 256 KL-LHKFNDVVWHVSWSITANILAVSGGDNKVTL-WKESVDGQWVC 299
Score = 40.4 bits (93), Expect = 0.003
Identities = 32/131 (24%), Positives = 51/131 (38%), Gaps = 24/131 (18%)
Query: 23 IAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAP-ESNRIVTCGTDRNAYVWTL 81
+A C + +V I+ + W K HE H+ V + WAP + I+ CG+ A +L
Sbjct: 74 LASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAI--SL 131
Query: 82 KGRTWKPTLVILRINRA----ARCVRWAPNE-----------------NKFAVGSGSRVI 120
T + + +IN A V WAP +FA G +I
Sbjct: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLI 191
Query: 121 SICYFEQENDW 131
+ E++ W
Sbjct: 192 KLWKEEEDGQW 202
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 50.4 bits (119), Expect = 2e-06
Identities = 63/277 (22%), Positives = 106/277 (38%), Gaps = 50/277 (18%)
Query: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVT 69
P+ +++ DR + + V ++ S +T + K HN V ++P V+
Sbjct: 545 PVYGASFSPDRNYLLSSSEDGTVRLW--SLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVS 602
Query: 70 CGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQEN 129
G DR A +W ++P + C R+ PN N A GS R + + N
Sbjct: 603 GGHDRVARLWATD--HYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660
Query: 130 DWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKM 189
C I + + SL + PN LA G+ D + ++ G +
Sbjct: 661 ----CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI--------------GHGL 702
Query: 190 PFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADK---------------- 233
GEL + + C + FS G +A S D+TV L DA K
Sbjct: 703 MVGELKGHTDTVC----SLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGH 758
Query: 234 --------KMAVATLASETLPLLALTFITDNSLVAAG 262
++ + T +++ P++ L F N ++AAG
Sbjct: 759 INLPENSQELLLGTYMTKSTPVVHLHFTRRNLVLAAG 795
Score = 44.3 bits (103), Expect = 2e-04
Identities = 48/218 (22%), Positives = 85/218 (38%), Gaps = 36/218 (16%)
Query: 51 HNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENK 110
H+G V G ++P+ N +++ D +W+L +T+ + N +++P
Sbjct: 542 HSGPVYGASFSPDRNYLLSSSEDGTVRLWSL--QTFTCLVGYKGHNYPVWDTQFSPYGYY 599
Query: 111 FAVGSGSRVISICYFEQENDWWVCKHIKKPIR------STVLSLDWHPNNVLLAAGSCDF 164
F G RV + W H +P+R + V +HPN+ +A GS D
Sbjct: 600 FVSGGHDRVARL---------WATDHY-QPLRIFAGHLADVNCTRFHPNSNYVATGSADR 649
Query: 165 KCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDS 224
R++ G + + G +H + FS +G +A + D
Sbjct: 650 TVRLWDVL------------------NGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDG 691
Query: 225 TVCLADADKKMAVATLASETLPLLALTFITDNSLVAAG 262
V L D + V L T + +L F D ++A+G
Sbjct: 692 RVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASG 729
>gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens]
Length = 606
Score = 48.1 bits (113), Expect = 1e-05
Identities = 50/208 (24%), Positives = 83/208 (39%), Gaps = 25/208 (12%)
Query: 15 AWNKDRTQIAICPNNHEVHIYEKSGAKW-----TKVHELKEHNGQVTGIDWAPESNRIVT 69
AW +D +IA+ E K GA + + V E+ HN + +D +
Sbjct: 109 AWTEDSKRIAVVGEGRE-----KFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLA 163
Query: 70 CGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQEN 129
G+D N + +G +K I +R CVR++P+ N+FA S I I ++ +
Sbjct: 164 TGSDDNCAAF-FEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYI--YDGKT 220
Query: 130 DWWVCK-HIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSK 188
VC K + ++ W P++ L + S D +I+ + V S
Sbjct: 221 GEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVV---------ST 271
Query: 189 MPFGELMFESSSSCGWV--HGVCFSASG 214
P G + + C W H + S SG
Sbjct: 272 FPMGSTVLDQQLGCLWQKDHLLSVSLSG 299
Score = 42.4 bits (98), Expect = 7e-04
Identities = 17/70 (24%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 11 ISCHAWNKDRTQIAICPNNHEVHIYE-KSGAKWTKVHELKEHNGQVTGIDWAPESNRIVT 69
++C ++ D + A + +++IY+ K+G K + K H+G + I W+P+S +++
Sbjct: 192 VNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLS 251
Query: 70 CGTDRNAYVW 79
D+ + +W
Sbjct: 252 ASGDKTSKIW 261
Score = 37.0 bits (84), Expect = 0.029
Identities = 16/72 (22%), Positives = 38/72 (52%), Gaps = 1/72 (1%)
Query: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVT 69
P++ A++ D +A+C + V ++ + +++ + H+ ++ + W+P++ +
Sbjct: 491 PVTDVAYSHDGAFLAVCDASKVVTVFSVADG-YSENNVFYGHHAKIVCLAWSPDNEHFAS 549
Query: 70 CGTDRNAYVWTL 81
G D YVWTL
Sbjct: 550 GGMDMMVYVWTL 561
Score = 30.4 bits (67), Expect = 2.7
Identities = 25/112 (22%), Positives = 47/112 (41%), Gaps = 9/112 (8%)
Query: 62 PESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVI- 120
P + + G D N ++++ G T K +L V ++ + AV S+V+
Sbjct: 455 PGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVT 514
Query: 121 --SICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFS 170
S+ EN+ + H K ++ L W P+N A+G D +++
Sbjct: 515 VFSVADGYSENNVFYGHHAK------IVCLAWSPDNEHFASGGMDMMVYVWT 560
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 44.7 bits (104), Expect = 1e-04
Identities = 41/219 (18%), Positives = 84/219 (38%), Gaps = 24/219 (10%)
Query: 44 KVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVR 103
K E K H V +D++ + + T D++ VW++ + + +L R RC +
Sbjct: 94 KFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLY--RHTHWVRCAK 151
Query: 104 WAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCD 163
++P+ S + I I + C + +D++P+ +A+ D
Sbjct: 152 FSPDGRLIVSCSEDKTIKIWDTTNKQ----CVNNFSDSVGFANFVDFNPSGTCIASAGSD 207
Query: 164 FKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHD 223
+++ + + L+ G V+ + F SG+ + S D
Sbjct: 208 QTVKVWDVRVNK------------------LLQHYQVHSGGVNCISFHPSGNYLITASSD 249
Query: 224 STVCLADADKKMAVATLASETLPLLALTFITDNSLVAAG 262
T+ + D + + TL T P+ ++F L A+G
Sbjct: 250 GTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASG 288
Score = 40.0 bits (92), Expect = 0.003
Identities = 38/191 (19%), Positives = 69/191 (36%), Gaps = 28/191 (14%)
Query: 49 KEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLK--GRTWKPTLVILRINRAARCVRWAP 106
K H +T +D +P ++ T D +W K R ++ + V+++P
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYR----YVGHKDVVTSVQFSP 70
Query: 107 NENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKC 166
+ N A S R + + ++ + K P+R S+D+ + LA S D
Sbjct: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVR----SVDFSADGQFLATASEDKSI 126
Query: 167 RIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTV 226
+++S Y + ++ WV FS G + S D T+
Sbjct: 127 KVWSMYRQ------------------RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTI 168
Query: 227 CLADADKKMAV 237
+ D K V
Sbjct: 169 KIWDTTNKQCV 179
Score = 29.6 bits (65), Expect = 4.6
Identities = 18/60 (30%), Positives = 28/60 (46%)
Query: 205 VHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLALTFITDNSLVAAGHD 264
V V FS G+ +A S D TV L DK+ + + T P+ ++ F D +A +
Sbjct: 63 VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122
>gi|34996489 pleckstrin homology domain interacting protein [Homo
sapiens]
Length = 1821
Score = 43.9 bits (102), Expect = 2e-04
Identities = 22/79 (27%), Positives = 38/79 (48%)
Query: 13 CHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGT 72
C +++ +A +H + +Y + K+ EL+ H +V I ++ SNR V+
Sbjct: 326 CSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSR 385
Query: 73 DRNAYVWTLKGRTWKPTLV 91
D A +W K R WK L+
Sbjct: 386 DGTARIWQFKRREWKSILL 404
>gi|46409657 WD repeat domain 56 [Homo sapiens]
Length = 777
Score = 43.1 bits (100), Expect = 4e-04
Identities = 33/132 (25%), Positives = 59/132 (44%), Gaps = 10/132 (7%)
Query: 44 KVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVR 103
KV + K H+G + +DW ++ I++ G D VW GR P V
Sbjct: 180 KVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGR---PLYNSQPHEHPITSVA 236
Query: 104 WAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCD 163
WAP+ FAVGS + +C + W ++KP ++ ++ W + + AG+C
Sbjct: 237 WAPDGELFAVGS-FHTLRLC---DKTGWSYA--LEKPNTGSIFNIAWSIDGTQI-AGACG 289
Query: 164 FKCRIFSAYIKE 175
+F+ +++
Sbjct: 290 NGHVVFAHVVEQ 301
Score = 35.8 bits (81), Expect = 0.064
Identities = 51/219 (23%), Positives = 86/219 (39%), Gaps = 30/219 (13%)
Query: 18 KDRTQ---IAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDR 74
K +TQ + ++ + H+ K G V + H G V W E +VT G D
Sbjct: 72 KKQTQAESFVLTSSDGKFHLISKLGRVEKSV---EAHCGAVLAGRWNYEGTALVTVGEDG 128
Query: 75 NAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVI--SICYFEQENDWW 132
+W+ G + TL + V W P+ K +G ++I + + W
Sbjct: 129 QIKIWSKTGML-RSTLA--QQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKVLQW- 184
Query: 133 VCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEV-EERPAPTPWGSK--M 189
K +L +DW+ N L+ + D K +++ +Y + + +P P S
Sbjct: 185 ------KAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHPITSVAWA 238
Query: 190 PFGELM----FESSSSC---GWVHGVCFSASGS--RVAW 219
P GEL F + C GW + + +GS +AW
Sbjct: 239 PDGELFAVGSFHTLRLCDKTGWSYALEKPNTGSIFNIAW 277
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 42.4 bits (98), Expect = 7e-04
Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 4/121 (3%)
Query: 51 HNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENK 110
H G V + AP++ V+ D +A +W ++ + T + A C + PN N
Sbjct: 183 HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC--FFPNGNA 240
Query: 111 FAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFS 170
FA GS + F+ D + + I + S+ + + LL AG DF C ++
Sbjct: 241 FATGSDDATCRL--FDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWD 298
Query: 171 A 171
A
Sbjct: 299 A 299
Score = 38.5 bits (88), Expect = 0.010
Identities = 49/233 (21%), Positives = 89/233 (38%), Gaps = 39/233 (16%)
Query: 44 KVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRA----- 98
KVH + + V +AP N + G D ++ LK R +R++R
Sbjct: 89 KVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGN-----VRVSRELAGHT 143
Query: 99 --ARCVRWAPNENKFAVGSGSRVISICYFEQ-ENDWWVCKHIKKPIRSTVLSLDWHPNNV 155
C R+ ++N+ SG ++ E + H V+SL P+
Sbjct: 144 GYLSCCRFL-DDNQIVTSSGDTTCALWDIETGQQTTTFTGH-----TGDVMSLSLAPDTR 197
Query: 156 LLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGS 215
L +G+CD ++ W + F S ++ +CF +G+
Sbjct: 198 LFVSGACDASAKL----------------WDVREGMCRQTFTGHESD--INAICFFPNGN 239
Query: 216 RVAWVSHDSTVCLAD--ADKKMAVATLASETLPLLALTFITDNSLVAAGHDCF 266
A S D+T L D AD+++ + + + +++F L+ AG+D F
Sbjct: 240 AFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDF 292
>gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo sapiens]
Length = 466
Score = 42.4 bits (98), Expect = 7e-04
Identities = 17/70 (24%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 11 ISCHAWNKDRTQIAICPNNHEVHIYE-KSGAKWTKVHELKEHNGQVTGIDWAPESNRIVT 69
++C ++ D + A + +++IY+ K+G K + K H+G + I W+P+S +++
Sbjct: 52 VNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLS 111
Query: 70 CGTDRNAYVW 79
D+ + +W
Sbjct: 112 ASGDKTSKIW 121
Score = 37.0 bits (84), Expect = 0.029
Identities = 16/72 (22%), Positives = 38/72 (52%), Gaps = 1/72 (1%)
Query: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVT 69
P++ A++ D +A+C + V ++ + +++ + H+ ++ + W+P++ +
Sbjct: 351 PVTDVAYSHDGAFLAVCDASKVVTVFSVADG-YSENNVFYGHHAKIVCLAWSPDNEHFAS 409
Query: 70 CGTDRNAYVWTL 81
G D YVWTL
Sbjct: 410 GGMDMMVYVWTL 421
Score = 35.0 bits (79), Expect = 0.11
Identities = 30/122 (24%), Positives = 50/122 (40%), Gaps = 14/122 (11%)
Query: 96 NRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCK-HIKKPIRSTVLSLDWHPNN 154
+R CVR++P+ N+FA S I I ++ + VC K + ++ W P++
Sbjct: 49 SRFVNCVRFSPDGNRFATASADGQIYI--YDGKTGEKVCALGGSKAHDGGIYAISWSPDS 106
Query: 155 VLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWV--HGVCFSA 212
L + S D +I+ + V S P G + + C W H + S
Sbjct: 107 THLLSASGDKTSKIWDVSVNSVV---------STFPMGSTVLDQQLGCLWQKDHLLSVSL 157
Query: 213 SG 214
SG
Sbjct: 158 SG 159
Score = 30.4 bits (67), Expect = 2.7
Identities = 25/112 (22%), Positives = 47/112 (41%), Gaps = 9/112 (8%)
Query: 62 PESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVI- 120
P + + G D N ++++ G T K +L V ++ + AV S+V+
Sbjct: 315 PGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVT 374
Query: 121 --SICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFS 170
S+ EN+ + H K ++ L W P+N A+G D +++
Sbjct: 375 VFSVADGYSENNVFYGHHAK------IVCLAWSPDNEHFASGGMDMMVYVWT 420
>gi|118402582 cell division cycle 20 [Homo sapiens]
Length = 499
Score = 42.0 bits (97), Expect = 9e-04
Identities = 39/141 (27%), Positives = 56/141 (39%), Gaps = 22/141 (15%)
Query: 28 NNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVW-TLKGR-T 85
++H+V + E V L H+ +V G+ WAP+ + + G D VW + G
Sbjct: 291 HHHDVRVAEHH------VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG 344
Query: 86 WKPTLVILRINRAARCVRWAP-NENKFAVGSGS--RVISICYFEQENDWWVCKHI---KK 139
W P + A + V W P N A G G+ R I I W VC
Sbjct: 345 WVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRI--------WNVCSGACLSAV 396
Query: 140 PIRSTVLSLDWHPNNVLLAAG 160
S V S+ W P+ L +G
Sbjct: 397 DAHSQVCSILWSPHYKELISG 417
>gi|46358428 selective LIM binding factor homolog [Homo sapiens]
Length = 1749
Score = 42.0 bits (97), Expect = 9e-04
Identities = 27/103 (26%), Positives = 51/103 (49%), Gaps = 10/103 (9%)
Query: 11 ISCHAWNKDRTQIAICPNNHEVHIYEKSGAK----WTKVHELK--EHNGQVTGIDWAPES 64
++C AW+++ + A+C + V +Y++ G + TK ++K + V G+ ++P+S
Sbjct: 19 VTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADMKYGRKSYMVKGMAFSPDS 78
Query: 65 NRIVTCGTDRNAYVWTLKGRTWKPTLVILR---INRAARCVRW 104
+I TD YV+ + G W VI A C++W
Sbjct: 79 TKIAIGQTDNIIYVYKI-GEDWGDKKVICNKFIQTSAVTCLQW 120
>gi|55769546 PAK1 interacting protein 1 [Homo sapiens]
Length = 392
Score = 42.0 bits (97), Expect = 9e-04
Identities = 23/74 (31%), Positives = 35/74 (47%), Gaps = 5/74 (6%)
Query: 41 KWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTL-KGRTWKPTLVILRINRAA 99
KW + +K H GQVT + P ++ GTD+ W L +GR + I I + A
Sbjct: 112 KWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGR----SAFIKNIKQNA 167
Query: 100 RCVRWAPNENKFAV 113
V W+P ++ V
Sbjct: 168 HIVEWSPRGEQYVV 181
Score = 32.7 bits (73), Expect = 0.54
Identities = 33/154 (21%), Positives = 60/154 (38%), Gaps = 13/154 (8%)
Query: 41 KWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAAR 100
+WT V + H + A S +VT D +++ +K + LV +
Sbjct: 29 QWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALV--HHSGTIT 86
Query: 101 CVRWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAG 160
C+++ N + SG+ IC ++ + W C K + V L HP+ L +
Sbjct: 87 CLKFYGNRHLI---SGAEDGLICIWDAKK--WECLKSIKAHKGQVTFLSIHPSGKLALSV 141
Query: 161 SCDFKCRIF------SAYIKEVEERPAPTPWGSK 188
D R + SA+IK +++ W +
Sbjct: 142 GTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPR 175
>gi|22749037 WD repeat domain 65 [Homo sapiens]
Length = 698
Score = 41.2 bits (95), Expect = 0.002
Identities = 25/89 (28%), Positives = 44/89 (49%), Gaps = 5/89 (5%)
Query: 28 NNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWK 87
N + +H+Y + + + LK H G++ I W + +++++ GTD Y W L T K
Sbjct: 490 NGNVIHVYTTTSLE--NISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLS--TGK 545
Query: 88 PTLVILRINRAARCVRWAPNEN-KFAVGS 115
+ + + CV +P+ FAVGS
Sbjct: 546 RETECVLKSCSYNCVTVSPDAKIIFAVGS 574
>gi|58331266 WD repeat domain 59 [Homo sapiens]
Length = 974
Score = 41.2 bits (95), Expect = 0.002
Identities = 35/139 (25%), Positives = 64/139 (46%), Gaps = 9/139 (6%)
Query: 28 NNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAP-ESNRIVTCGTDRNAYVWTLKGRTW 86
+N V +Y+ L+ H ++ +DWA E + +VT D Y+W +K T
Sbjct: 81 SNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKD-TR 139
Query: 87 KPTLVILRINRAARCVRW-APNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTV 145
KPT+ + + A++ V+W N N A + +++ +++ + S +
Sbjct: 140 KPTVALSAVAGASQ-VKWNKKNANCLATSHDG---DVRIWDKRKPSTAVEYLAAHL-SKI 194
Query: 146 LSLDWHPNNV-LLAAGSCD 163
LDWHP++ +LA S D
Sbjct: 195 HGLDWHPDSEHILATSSQD 213
Score = 35.8 bits (81), Expect = 0.064
Identities = 19/65 (29%), Positives = 30/65 (46%), Gaps = 2/65 (3%)
Query: 16 WNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIV-TCGTDR 74
WNK ++ +V I++K T V L H ++ G+DW P+S I+ T D
Sbjct: 156 WNKKNANCLATSHDGDVRIWDKRKPS-TAVEYLAAHLSKIHGLDWHPDSEHILATSSQDN 214
Query: 75 NAYVW 79
+ W
Sbjct: 215 SVKFW 219
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 40.8 bits (94), Expect = 0.002
Identities = 47/215 (21%), Positives = 78/215 (36%), Gaps = 23/215 (10%)
Query: 48 LKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPN 107
LK H +T + + +T DR +W TL R N P
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHR-NVVYAIAFNNPY 146
Query: 108 ENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCR 167
+K A GS + + E C H + + ++ L ++P + L+A GS D +
Sbjct: 147 GDKIATGSFDKTCKLWSVETGK----CYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAK 202
Query: 168 IFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVC 227
++ + GE ++ + + F+ SG R+ S D TV
Sbjct: 203 LWD------------------IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVV 244
Query: 228 LADADKKMAVATLASETLPLLALTFITDNSLVAAG 262
+ DAD V L + + +F D SL+ G
Sbjct: 245 VWDADTGRKVNILIGHCAEISSASFNWDCSLILTG 279
Score = 32.0 bits (71), Expect = 0.92
Identities = 50/263 (19%), Positives = 95/263 (36%), Gaps = 30/263 (11%)
Query: 3 YHSFL--VEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDW 60
YH+F I C ++N T +A + +++ + +V+ L+ H+ ++ + +
Sbjct: 170 YHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGE--EVYTLRGHSAEIISLSF 227
Query: 61 APESNRIVTCGTDRNAYVWTL-KGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRV 119
+RI+T D VW GR V + I A + N + + +GS
Sbjct: 228 NTSGDRIITGSFDHTVVVWDADTGRK-----VNILIGHCAEISSASFNWDCSLILTGSMD 282
Query: 120 ISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEER 179
+ ++ N C +L + L+A S D RIFSA +
Sbjct: 283 KTCKLWDATNG--KCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATR----- 335
Query: 180 PAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVAT 239
+ + + G + + F+ G+ + S D T + DA +
Sbjct: 336 -------------KCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQV 382
Query: 240 LASETLPLLALTFITDNSLVAAG 262
L T + + F ++V G
Sbjct: 383 LEGHTDEIFSCAFNYKGNIVITG 405
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 40.4 bits (93), Expect = 0.003
Identities = 55/264 (20%), Positives = 99/264 (37%), Gaps = 37/264 (14%)
Query: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVT 69
P+ + D + + C + + ++ T +++ H V +D +P S +
Sbjct: 344 PVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQ--GHAYPVWDLDISPYSLYFAS 401
Query: 70 CGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQEN 129
DR A +W+ RT+ P + CV++ PN N A GS + + + +Q N
Sbjct: 402 GSHDRTARLWSFD-RTY-PLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGN 459
Query: 130 DWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKM 189
+ R VLSL + PN LA+ D + +++ +
Sbjct: 460 S----VRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWD------------------L 497
Query: 190 PFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTV---------CLADADKKMA--VA 238
G L E + + FS +A S D++V C A AD + V
Sbjct: 498 ASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVG 557
Query: 239 TLASETLPLLALTFITDNSLVAAG 262
+ +L++ F+ N L+ G
Sbjct: 558 VYTGQMSNVLSVQFMACNLLLVTG 581
Score = 37.7 bits (86), Expect = 0.017
Identities = 50/220 (22%), Positives = 86/220 (39%), Gaps = 26/220 (11%)
Query: 43 TKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCV 102
T++ L+ H G V + +S+ +++C D + W L T T++ +
Sbjct: 333 TEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFT--NTVLYQGHAYPVWDL 390
Query: 103 RWAPNENKFAVGSGSRVISICYFEQENDWWV-CKHIKKPIRSTVLSLDWHPNNVLLAAGS 161
+P FA GS R + F++ + H+ + V + +HPN+ LA GS
Sbjct: 391 DISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHL-----ADVDCVKFHPNSNYLATGS 445
Query: 162 CDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVS 221
D R++SA G + + G V + FS +G +A
Sbjct: 446 TDKTVRLWSA------------------QQGNSVRLFTGHRGPVLSLAFSPNGKYLASAG 487
Query: 222 HDSTVCLADADKKMAVATLASETLPLLALTFITDNSLVAA 261
D + L D L T + +LTF D+ L+A+
Sbjct: 488 EDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIAS 527
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 39.7 bits (91), Expect = 0.004
Identities = 43/187 (22%), Positives = 73/187 (39%), Gaps = 34/187 (18%)
Query: 12 SCHAWNKDRTQI--------AIC----PNNHEVHIYEKSG-------AKWTKVHELKEHN 52
S WN+ Q A+C P + +V I K+G A + + H+
Sbjct: 437 SIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHD 496
Query: 53 GQVTGIDWAPESNRIVTCGTDRNAYVW----------TLKGRTWKPTLVILRINRAARCV 102
G + + +P+ VT G D++ W T K + K T L+++ CV
Sbjct: 497 GALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRT-LQLDEDVLCV 555
Query: 103 RWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSC 162
++PN+ AV + I Y + + K P V+ +D + L+A GS
Sbjct: 556 SYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLP----VICMDISHDGALIATGSA 611
Query: 163 DFKCRIF 169
D +I+
Sbjct: 612 DRNVKIW 618
>gi|186928847 cirhin [Homo sapiens]
Length = 686
Score = 39.7 bits (91), Expect = 0.004
Identities = 43/169 (25%), Positives = 71/169 (42%), Gaps = 19/169 (11%)
Query: 3 YHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVT-GIDWA 61
+ +++ I C A+N ++A+ + V IY S A + + H + T + WA
Sbjct: 11 FFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLS-ANYFQEKFFPGHESRATEALCWA 69
Query: 62 PESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVI- 120
E R+ + G L G + L L I A P + A SGS+++
Sbjct: 70 -EGQRLFSAG---------LNGEIMEYDLQALNIKYAMDAFG-GPIWSMAASPSGSQLLV 118
Query: 121 -----SICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDF 164
S+ F+ D + +S +LSL WHP+ +AAGS D+
Sbjct: 119 GCEDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDY 167
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.132 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,434,462
Number of Sequences: 37866
Number of extensions: 623412
Number of successful extensions: 2204
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 74
Number of HSP's successfully gapped in prelim test: 82
Number of HSP's that attempted gapping in prelim test: 1664
Number of HSP's gapped (non-prelim): 499
length of query: 372
length of database: 18,247,518
effective HSP length: 104
effective length of query: 268
effective length of database: 14,309,454
effective search space: 3834933672
effective search space used: 3834933672
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.