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Search of human proteins with 4885649
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4885649 SUMO-1 activating enzyme subunit 2 [Homo sapiens]
(640 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4885649 SUMO-1 activating enzyme subunit 2 [Homo sapiens] 1274 0.0
gi|38045944 ubiquitin-activating enzyme 3 isoform 2 [Homo sapiens] 160 3e-39
gi|38045942 ubiquitin-activating enzyme 3 isoform 1 [Homo sapiens] 160 3e-39
gi|23510338 ubiquitin-activating enzyme E1 [Homo sapiens] 158 1e-38
gi|23510340 ubiquitin-activating enzyme E1 [Homo sapiens] 158 1e-38
gi|38045948 ubiquitin-like modifier activating enzyme 7 [Homo sa... 131 2e-30
gi|150417996 ubiquitin-activating enzyme E1-like 2 [Homo sapiens] 120 4e-27
gi|7657339 molybdenum cofactor synthesis 3 [Homo sapiens] 81 3e-15
gi|38327032 ubiquitin-activating enzyme 5 isoform 2 [Homo sapiens] 62 2e-09
gi|13376212 ubiquitin-activating enzyme 5 isoform 1 [Homo sapiens] 62 2e-09
gi|225543288 SUMO1 activating enzyme subunit 1 isoform c [Homo s... 58 3e-08
gi|225543285 SUMO1 activating enzyme subunit 1 isoform b [Homo s... 58 3e-08
gi|4885585 SUMO1 activating enzyme subunit 1 isoform a [Homo sap... 58 3e-08
gi|7705473 SUMO1 activating enzyme subunit 1 isoform a [Homo sap... 58 3e-08
gi|66363686 NEDD8 activating enzyme E1 subunit 1 isoform b [Homo... 51 4e-06
gi|4502169 NEDD8 activating enzyme E1 subunit 1 isoform a [Homo ... 51 4e-06
gi|222144229 APG7 autophagy 7-like isoform c [Homo sapiens] 48 3e-05
gi|222144227 APG7 autophagy 7-like isoform b [Homo sapiens] 48 3e-05
gi|5453668 APG7 autophagy 7-like isoform a [Homo sapiens] 48 3e-05
gi|195976782 Paf1/RNA polymerase II complex component [Homo sapi... 40 0.009
gi|60302875 shugoshin-like 1 isoform A1 [Homo sapiens] 39 0.011
gi|60302870 shugoshin-like 1 isoform A2 [Homo sapiens] 39 0.011
gi|45505139 phosphoinositide-3-kinase adaptor protein 1 [Homo sa... 39 0.015
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 39 0.019
gi|17975763 myelin transcription factor 1 [Homo sapiens] 38 0.033
gi|146219843 Snf2-related CBP activator protein [Homo sapiens] 38 0.033
gi|117938268 E2F-associated phosphoprotein [Homo sapiens] 36 0.12
gi|13540523 nucleosomal binding protein 1 [Homo sapiens] 35 0.16
gi|55769548 PHD finger protein 14 isoform 2 [Homo sapiens] 35 0.16
gi|55769550 PHD finger protein 14 isoform 1 [Homo sapiens] 35 0.16
>gi|4885649 SUMO-1 activating enzyme subunit 2 [Homo sapiens]
Length = 640
Score = 1274 bits (3297), Expect = 0.0
Identities = 640/640 (100%), Positives = 640/640 (100%)
Query: 1 MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQ 60
MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQ
Sbjct: 1 MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQ 60
Query: 61 FLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRA 120
FLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRA
Sbjct: 61 FLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRA 120
Query: 121 ARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPS 180
ARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPS
Sbjct: 121 ARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPS 180
Query: 181 EPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRIST 240
EPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRIST
Sbjct: 181 EPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRIST 240
Query: 241 KEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEETNASDQQ 300
KEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEETNASDQQ
Sbjct: 241 KEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEETNASDQQ 300
Query: 301 NEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAAN 360
NEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAAN
Sbjct: 301 NEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAAN 360
Query: 361 LRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNK 420
LRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNK
Sbjct: 361 LRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNK 420
Query: 421 QPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDV 480
QPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDV
Sbjct: 421 QPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDV 480
Query: 481 QIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGK 540
QIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGK
Sbjct: 481 QIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGK 540
Query: 541 DVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNN 600
DVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNN
Sbjct: 541 DVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNN 600
Query: 601 ADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD 640
ADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD
Sbjct: 601 ADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD 640
>gi|38045944 ubiquitin-activating enzyme 3 isoform 2 [Homo sapiens]
Length = 449
Score = 160 bits (406), Expect = 3e-39
Identities = 99/236 (41%), Positives = 135/236 (57%), Gaps = 19/236 (8%)
Query: 19 RVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKE 78
+VLV+GAGG+GCELLKNL L+GF I +ID+DTIDVSNLNRQFLF+ K +GR KA+VA E
Sbjct: 57 KVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAE 116
Query: 79 SVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCL-------- 130
+ P N+V + + I D+N F+RQF +++ LD+ AR +N M +
Sbjct: 117 FLNDRVPNCNVVPHFNKIQ--DFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDG 174
Query: 131 ----AADVPLIESGTAGYLGQVTTIKKGVTECYECHPK--PTQRTFPGCTIRNTPSEPIH 184
++ VPLI+ GT G+ G I G+T C EC + P Q FP CTI + P P H
Sbjct: 175 VLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEH 234
Query: 185 CIVWAKYLFNQLFGEEDADQEVSPDRADPE-AAWEPTEAEARARASNEDGDIKRIS 239
CI + + L Q E+ + V D DPE W ++ RA N G R++
Sbjct: 235 CIEYVRML--QWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYRLT 288
Score = 41.2 bits (95), Expect = 0.003
Identities = 54/227 (23%), Positives = 87/227 (38%), Gaps = 15/227 (6%)
Query: 315 VKSYARLFSKSIETLRVHLAEK----GDGAELIWDKDDPSAMDFVTSAANLRMHIFSMNM 370
+ S RL IE +R+ K G+G L D DDP + ++ + R +++
Sbjct: 225 IASMPRLPEHCIEYVRMLQWPKEQPFGEGVPL--DGDDPEHIQWIFQKSLERASQYNIRG 282
Query: 371 KSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLV 430
+ + + IIPA+A+TNAVIA + E KI + + N L
Sbjct: 283 VTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVF---NDVDGLYT 339
Query: 431 PCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDVQIE-DGKGTI 489
NC C+ P+ ++ + L M +P + +GK
Sbjct: 340 YTFEAERKENCPACSQLPQ-NIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRT 398
Query: 490 L----ISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINI 532
L ++S E T N K L E G+ +G L D T+L +
Sbjct: 399 LYLQSVTSIEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKL 445
>gi|38045942 ubiquitin-activating enzyme 3 isoform 1 [Homo sapiens]
Length = 463
Score = 160 bits (406), Expect = 3e-39
Identities = 99/236 (41%), Positives = 135/236 (57%), Gaps = 19/236 (8%)
Query: 19 RVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKE 78
+VLV+GAGG+GCELLKNL L+GF I +ID+DTIDVSNLNRQFLF+ K +GR KA+VA E
Sbjct: 71 KVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAE 130
Query: 79 SVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCL-------- 130
+ P N+V + + I D+N F+RQF +++ LD+ AR +N M +
Sbjct: 131 FLNDRVPNCNVVPHFNKIQ--DFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDG 188
Query: 131 ----AADVPLIESGTAGYLGQVTTIKKGVTECYECHPK--PTQRTFPGCTIRNTPSEPIH 184
++ VPLI+ GT G+ G I G+T C EC + P Q FP CTI + P P H
Sbjct: 189 VLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEH 248
Query: 185 CIVWAKYLFNQLFGEEDADQEVSPDRADPE-AAWEPTEAEARARASNEDGDIKRIS 239
CI + + L Q E+ + V D DPE W ++ RA N G R++
Sbjct: 249 CIEYVRML--QWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYRLT 302
Score = 41.2 bits (95), Expect = 0.003
Identities = 54/227 (23%), Positives = 87/227 (38%), Gaps = 15/227 (6%)
Query: 315 VKSYARLFSKSIETLRVHLAEK----GDGAELIWDKDDPSAMDFVTSAANLRMHIFSMNM 370
+ S RL IE +R+ K G+G L D DDP + ++ + R +++
Sbjct: 239 IASMPRLPEHCIEYVRMLQWPKEQPFGEGVPL--DGDDPEHIQWIFQKSLERASQYNIRG 296
Query: 371 KSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLV 430
+ + + IIPA+A+TNAVIA + E KI + + N L
Sbjct: 297 VTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVF---NDVDGLYT 353
Query: 431 PCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDVQIE-DGKGTI 489
NC C+ P+ ++ + L M +P + +GK
Sbjct: 354 YTFEAERKENCPACSQLPQ-NIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRT 412
Query: 490 L----ISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINI 532
L ++S E T N K L E G+ +G L D T+L +
Sbjct: 413 LYLQSVTSIEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKL 459
>gi|23510338 ubiquitin-activating enzyme E1 [Homo sapiens]
Length = 1058
Score = 158 bits (400), Expect = 1e-38
Identities = 149/477 (31%), Positives = 227/477 (47%), Gaps = 76/477 (15%)
Query: 10 ELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFS-----HIDLIDLDTIDVSNLNRQFLFQ 64
+L E + + +VGAG IGCELLKN + G I + D+DTI+ SNLNRQFLF+
Sbjct: 461 DLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFR 520
Query: 65 KKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPD----YNVEFFRQFILVMNALDNRA 120
V + K+ A +V Q P + + H + + PD Y+ +FF+ V NALDN
Sbjct: 521 PWDVTKLKSDTAAAAVRQMNPHIRVTS-HQNRVGPDTERIYDDDFFQNLDGVANALDNVD 579
Query: 121 ARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPS 180
AR +++R C+ PL+ESGT G G V + +TE Y P +++ P CT++N P+
Sbjct: 580 ARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPN 639
Query: 181 EPIHCIVWAKYLFNQLFGE--EDADQEVSP----DRADPEAAWEPTEAEARARASNEDGD 234
H + WA+ F LF + E+ +Q ++ +R A +P E A
Sbjct: 640 AIEHTLQWARDEFEGLFKQPAENVNQYLTDPKFVERTLRLAGTQPLEV---LEAVQRSLV 696
Query: 235 IKRISTKEWAKSTGYDPVKLFTKLFKDDIRYLL---TMDKL-------WR--KRKP---- 278
++R T WA + T+ + ++IR LL D+L W KR P
Sbjct: 697 LQRPQT--WADCVTWACHHWHTQ-YSNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLT 753
Query: 279 -----PVPLDWAEVQ------------SQGEETNASDQQN------EPQLGLK----DQQ 311
P+ LD+ SQ A+ Q+ P+ G+K DQ+
Sbjct: 754 FDVNNPLHLDYVMAAANLFAQTYGLTGSQDRAAVATFLQSVQVPEFTPKSGVKIHVSDQE 813
Query: 312 VLDVKSYARLFSKSIETLRVHL--AEKGDGAELI---WDKDDPS--AMDFVTSAANLRMH 364
+ A + +E L+ L +K G ++ ++KDD S MDF+ +A+NLR
Sbjct: 814 LQSAN--ASVDDSRLEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIVAASNLRAE 871
Query: 365 IFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSG--KIDQCRTIFLN 419
+ + R K +AG IIPAIATT A + GL+ LE K++ G ++D + FLN
Sbjct: 872 NYDIPSADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHRQLDSYKNGFLN 928
Score = 54.7 bits (130), Expect = 3e-07
Identities = 35/142 (24%), Positives = 71/142 (50%), Gaps = 5/142 (3%)
Query: 7 LPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKK 66
L E + + VLV G G+G E+ KN++L G + L D T ++L+ QF +++
Sbjct: 62 LGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLREE 121
Query: 67 HVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVN 126
+G+++A+V++ + + + AY ++ D+ + F+ +L L+++ V
Sbjct: 122 DIGKNRAEVSQPRLAELNSYVPVTAYTGPLVE-DF-LSGFQVVVLTNTPLEDQL---RVG 176
Query: 127 RMCLAADVPLIESGTAGYLGQV 148
C + L+ + T G GQ+
Sbjct: 177 EFCHNRGIKLVVADTRGLFGQL 198
>gi|23510340 ubiquitin-activating enzyme E1 [Homo sapiens]
Length = 1058
Score = 158 bits (400), Expect = 1e-38
Identities = 149/477 (31%), Positives = 227/477 (47%), Gaps = 76/477 (15%)
Query: 10 ELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFS-----HIDLIDLDTIDVSNLNRQFLFQ 64
+L E + + +VGAG IGCELLKN + G I + D+DTI+ SNLNRQFLF+
Sbjct: 461 DLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFR 520
Query: 65 KKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPD----YNVEFFRQFILVMNALDNRA 120
V + K+ A +V Q P + + H + + PD Y+ +FF+ V NALDN
Sbjct: 521 PWDVTKLKSDTAAAAVRQMNPHIRVTS-HQNRVGPDTERIYDDDFFQNLDGVANALDNVD 579
Query: 121 ARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPS 180
AR +++R C+ PL+ESGT G G V + +TE Y P +++ P CT++N P+
Sbjct: 580 ARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPN 639
Query: 181 EPIHCIVWAKYLFNQLFGE--EDADQEVSP----DRADPEAAWEPTEAEARARASNEDGD 234
H + WA+ F LF + E+ +Q ++ +R A +P E A
Sbjct: 640 AIEHTLQWARDEFEGLFKQPAENVNQYLTDPKFVERTLRLAGTQPLEV---LEAVQRSLV 696
Query: 235 IKRISTKEWAKSTGYDPVKLFTKLFKDDIRYLL---TMDKL-------WR--KRKP---- 278
++R T WA + T+ + ++IR LL D+L W KR P
Sbjct: 697 LQRPQT--WADCVTWACHHWHTQ-YSNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLT 753
Query: 279 -----PVPLDWAEVQ------------SQGEETNASDQQN------EPQLGLK----DQQ 311
P+ LD+ SQ A+ Q+ P+ G+K DQ+
Sbjct: 754 FDVNNPLHLDYVMAAANLFAQTYGLTGSQDRAAVATFLQSVQVPEFTPKSGVKIHVSDQE 813
Query: 312 VLDVKSYARLFSKSIETLRVHL--AEKGDGAELI---WDKDDPS--AMDFVTSAANLRMH 364
+ A + +E L+ L +K G ++ ++KDD S MDF+ +A+NLR
Sbjct: 814 LQSAN--ASVDDSRLEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIVAASNLRAE 871
Query: 365 IFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSG--KIDQCRTIFLN 419
+ + R K +AG IIPAIATT A + GL+ LE K++ G ++D + FLN
Sbjct: 872 NYDIPSADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHRQLDSYKNGFLN 928
Score = 54.7 bits (130), Expect = 3e-07
Identities = 35/142 (24%), Positives = 71/142 (50%), Gaps = 5/142 (3%)
Query: 7 LPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKK 66
L E + + VLV G G+G E+ KN++L G + L D T ++L+ QF +++
Sbjct: 62 LGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLREE 121
Query: 67 HVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVN 126
+G+++A+V++ + + + AY ++ D+ + F+ +L L+++ V
Sbjct: 122 DIGKNRAEVSQPRLAELNSYVPVTAYTGPLVE-DF-LSGFQVVVLTNTPLEDQL---RVG 176
Query: 127 RMCLAADVPLIESGTAGYLGQV 148
C + L+ + T G GQ+
Sbjct: 177 EFCHNRGIKLVVADTRGLFGQL 198
>gi|38045948 ubiquitin-like modifier activating enzyme 7 [Homo
sapiens]
Length = 1012
Score = 131 bits (329), Expect = 2e-30
Identities = 131/443 (29%), Positives = 189/443 (42%), Gaps = 59/443 (13%)
Query: 21 LVVGAGGIGCELLKNLVLTGFSH-----IDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQV 75
L+VGAG IGCELLK L G + ++D+D I+ SNL+RQFLF+ + VGR KA+V
Sbjct: 436 LLVGAGAIGCELLKVFALVGLGAGNSGGLTVVDMDHIERSNLSRQFLFRSQDVGRPKAEV 495
Query: 76 AKESVLQFYPKANIVAYH---DSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLAA 132
A + P ++ D Y FF + V ALD+ AR +V C
Sbjct: 496 AAAAARGLNPDLQVIPLTYPLDPTTEHIYGDNFFSRVDGVAAALDSFQARRYVAARCTHY 555
Query: 133 DVPLIESGTAGYLGQVTTIKKGVTECYECHPKPT---QRTFPGCTIRNTPSEPIHCIVWA 189
PL+E+GT+G G T VTE Y +P CT+R PS H + WA
Sbjct: 556 LKPLLEAGTSGTWGSATVFMPHVTEAYRAPASAAASEDAPYPVCTVRYFPSTAEHTLQWA 615
Query: 190 KY----LFNQLFGEEDADQEVSPDRADPE-----AAWEPTEAEARARASNEDGDIKRIST 240
++ LF + Q+ AD + +P R R N D +
Sbjct: 616 RHEFEELFRLSAETINHHQQAHTSLADMDEPQTLTLLKPVLGVLRVRPQNWQ-DCVAWAL 674
Query: 241 KEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKP-PVPLDW--------------A 285
W Y +K + F + + L W K P PL++ A
Sbjct: 675 GHWKLCFHYG-IKQLLRHFPPN-KVLEDGTPFWSGPKQCPQPLEFDTNQDTHLLYVLAAA 732
Query: 286 EVQSQGEETNASDQQNEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAE---- 341
+ +Q S + LK D + A +F+ ++E L AE G +
Sbjct: 733 NLYAQMHGLPGSQDWTALRELLKLLPQPDPQQMAPIFASNLE-LASASAEFGPEQQKELN 791
Query: 342 --------------LIWDKDDPSA--MDFVTSAANLRMHIFSMNMKSRFDIKSMAGNIIP 385
L+++KDD S +DFV +AA+LR + + +R K + G IIP
Sbjct: 792 KALEVWSVGPPLKPLMFEKDDDSNFHVDFVVAAASLRCQNYGIPPVNRAQSKRIVGQIIP 851
Query: 386 AIATTNAVIAGLIVLEGLKILSG 408
AIATT A +AGL+ LE K++SG
Sbjct: 852 AIATTTAAVAGLLGLELYKVVSG 874
Score = 55.5 bits (132), Expect = 2e-07
Identities = 38/136 (27%), Positives = 63/136 (46%), Gaps = 5/136 (3%)
Query: 13 EAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSK 72
+ + G RVLV G G+G E+ KNLVL G + L D S+L QFL ++ + RS+
Sbjct: 28 QRIQGARVLVSGLQGLGAEVAKNLVLMGVGSLTLHDPHPTCWSDLAAQFLLSEQDLERSR 87
Query: 73 AQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLAA 132
A+ ++E + Q +V + D + F +V+ + V +C
Sbjct: 88 AEASQELLAQLNRAVQVVVH-----TGDITEDLLLDFQVVVLTAAKLEEQLKVGTLCHKH 142
Query: 133 DVPLIESGTAGYLGQV 148
V + + T G +GQ+
Sbjct: 143 GVCFLAADTRGLVGQL 158
>gi|150417996 ubiquitin-activating enzyme E1-like 2 [Homo sapiens]
Length = 1052
Score = 120 bits (301), Expect = 4e-27
Identities = 69/199 (34%), Positives = 104/199 (52%), Gaps = 9/199 (4%)
Query: 11 LAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSH------IDLIDLDTIDVSNLNRQFLFQ 64
L + + + +VG G IGCE+LKN L G I + D D I+ SNLNRQFLF+
Sbjct: 454 LCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFR 513
Query: 65 KKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPD---YNVEFFRQFILVMNALDNRAA 121
H+ + K+ A ++ L+ + I A+ + + YN EF+ + +++ ALDN A
Sbjct: 514 PHHIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEA 573
Query: 122 RNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPSE 181
R +V+ CLA PL++SGT G G I +TE Y H P + P CT+++ P+
Sbjct: 574 RRYVDSRCLANLRPLLDSGTMGTKGHTEVIVPHLTESYNSHRDPPEEEIPFCTLKSFPAA 633
Query: 182 PIHCIVWAKYLFNQLFGEE 200
H I WA+ F F +
Sbjct: 634 IEHTIQWARDKFESSFSHK 652
Score = 66.2 bits (160), Expect = 9e-11
Identities = 36/83 (43%), Positives = 53/83 (63%), Gaps = 3/83 (3%)
Query: 340 AELIWDKDDP--SAMDFVTSAANLRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGL 397
A L ++KDD +DF+T+A+NLR ++S+ RF K +AG IIPAIATT A ++GL
Sbjct: 845 AVLSFEKDDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTATVSGL 904
Query: 398 IVLEGLKILSG-KIDQCRTIFLN 419
+ LE +K+ G + + FLN
Sbjct: 905 VALEMIKVTGGYPFEAYKNCFLN 927
Score = 41.2 bits (95), Expect = 0.003
Identities = 38/181 (20%), Positives = 70/181 (38%), Gaps = 31/181 (17%)
Query: 13 EAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHV--GR 70
+ +A V + G GG+G E+ KNLVL G + + D + +L F + V R
Sbjct: 57 QKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKR 116
Query: 71 SKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMC- 129
++A+ + + + P ++ + N ++ F ++ V+ + +N C
Sbjct: 117 NRAEAVLKHIAELNPYVHVTS-SSVPFNETTDLSFLDKYQCVVLTEMKLPLQKKINDFCR 175
Query: 130 --------LAADVPLIES-------------GTAG------YLGQVTTIKKGVTECYECH 162
++ADV I S T G ++ +T G+ C E H
Sbjct: 176 SQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQANPGIVTCLENH 235
Query: 163 P 163
P
Sbjct: 236 P 236
>gi|7657339 molybdenum cofactor synthesis 3 [Homo sapiens]
Length = 460
Score = 80.9 bits (198), Expect = 3e-15
Identities = 47/147 (31%), Positives = 74/147 (50%), Gaps = 2/147 (1%)
Query: 20 VLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKES 79
VL+VG GG+GC L + L G + L+D D +++SNL RQ L + G++KA A S
Sbjct: 85 VLIVGCGGLGCPLAQYLAAAGVGRLGLVDYDVVEMSNLARQVLHGEALAGQAKAFSAAAS 144
Query: 80 VLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLAADVPLIES 139
+ + V Y + + P ++ R++ +V + DN R VN C+ A PL+ +
Sbjct: 145 LRRLNSAVECVPYTQA-LTPATALDLVRRYDVVADCSDNVPTRYLVNDACVLAGRPLVSA 203
Query: 140 GTAGYLGQVTTIKKGVTECYEC-HPKP 165
+ GQ+T CY C P+P
Sbjct: 204 SALRFEGQITVYHYDGGPCYRCIFPQP 230
>gi|38327032 ubiquitin-activating enzyme 5 isoform 2 [Homo sapiens]
Length = 348
Score = 61.6 bits (148), Expect = 2e-09
Identities = 45/161 (27%), Positives = 71/161 (44%), Gaps = 22/161 (13%)
Query: 20 VLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKES 79
V +VG GG+G + L G + L D D ++++N+NR F FQ G SK Q A+ +
Sbjct: 20 VAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLF-FQPHQAGLSKVQAAEHT 78
Query: 80 VLQFYPKANIVAYHDSIMNPDYNVEFFRQFI---------------LVMNALDNRAARNH 124
+ P ++ +I VE F+ F+ LV++ +DN AR
Sbjct: 79 LRNINPDVLFEVHNYNIT----TVENFQHFMDRISNGGLEEGKPVDLVLSCVDNFEARMT 134
Query: 125 VNRMCLAADVPLIESGTA--GYLGQVTTIKKGVTECYECHP 163
+N C +ESG + G + I G + C+ C P
Sbjct: 135 INTACNELGQTWMESGVSENAVSGHIQLIIPGESACFACAP 175
>gi|13376212 ubiquitin-activating enzyme 5 isoform 1 [Homo sapiens]
Length = 404
Score = 61.6 bits (148), Expect = 2e-09
Identities = 45/161 (27%), Positives = 71/161 (44%), Gaps = 22/161 (13%)
Query: 20 VLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKES 79
V +VG GG+G + L G + L D D ++++N+NR F FQ G SK Q A+ +
Sbjct: 76 VAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLF-FQPHQAGLSKVQAAEHT 134
Query: 80 VLQFYPKANIVAYHDSIMNPDYNVEFFRQFI---------------LVMNALDNRAARNH 124
+ P ++ +I VE F+ F+ LV++ +DN AR
Sbjct: 135 LRNINPDVLFEVHNYNIT----TVENFQHFMDRISNGGLEEGKPVDLVLSCVDNFEARMT 190
Query: 125 VNRMCLAADVPLIESGTA--GYLGQVTTIKKGVTECYECHP 163
+N C +ESG + G + I G + C+ C P
Sbjct: 191 INTACNELGQTWMESGVSENAVSGHIQLIIPGESACFACAP 231
>gi|225543288 SUMO1 activating enzyme subunit 1 isoform c [Homo
sapiens]
Length = 266
Score = 57.8 bits (138), Expect = 3e-08
Identities = 38/138 (27%), Positives = 63/138 (45%), Gaps = 4/138 (2%)
Query: 10 ELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVG 69
E + + RVL+VG G+G E+ KNL+L G + ++D + + + QFL + VG
Sbjct: 29 EAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVG 88
Query: 70 RSKAQVAKESVLQFYPKANI-VAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRM 128
R++A+ + E P ++ V D P+ FF QF V +R V+++
Sbjct: 89 RNRAEASLERAQNLNPMVDVKVDTEDIEKKPE---SFFTQFDAVCLTCCSRDVIVKVDQI 145
Query: 129 CLAADVPLIESGTAGYLG 146
C + GY G
Sbjct: 146 CHKNSIKFFTGDVFGYHG 163
>gi|225543285 SUMO1 activating enzyme subunit 1 isoform b [Homo
sapiens]
Length = 299
Score = 57.8 bits (138), Expect = 3e-08
Identities = 38/138 (27%), Positives = 63/138 (45%), Gaps = 4/138 (2%)
Query: 10 ELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVG 69
E + + RVL+VG G+G E+ KNL+L G + ++D + + + QFL + VG
Sbjct: 29 EAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVG 88
Query: 70 RSKAQVAKESVLQFYPKANI-VAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRM 128
R++A+ + E P ++ V D P+ FF QF V +R V+++
Sbjct: 89 RNRAEASLERAQNLNPMVDVKVDTEDIEKKPE---SFFTQFDAVCLTCCSRDVIVKVDQI 145
Query: 129 CLAADVPLIESGTAGYLG 146
C + GY G
Sbjct: 146 CHKNSIKFFTGDVFGYHG 163
>gi|4885585 SUMO1 activating enzyme subunit 1 isoform a [Homo
sapiens]
Length = 346
Score = 57.8 bits (138), Expect = 3e-08
Identities = 38/138 (27%), Positives = 63/138 (45%), Gaps = 4/138 (2%)
Query: 10 ELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVG 69
E + + RVL+VG G+G E+ KNL+L G + ++D + + + QFL + VG
Sbjct: 29 EAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVG 88
Query: 70 RSKAQVAKESVLQFYPKANI-VAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRM 128
R++A+ + E P ++ V D P+ FF QF V +R V+++
Sbjct: 89 RNRAEASLERAQNLNPMVDVKVDTEDIEKKPE---SFFTQFDAVCLTCCSRDVIVKVDQI 145
Query: 129 CLAADVPLIESGTAGYLG 146
C + GY G
Sbjct: 146 CHKNSIKFFTGDVFGYHG 163
>gi|7705473 SUMO1 activating enzyme subunit 1 isoform a [Homo
sapiens]
Length = 346
Score = 57.8 bits (138), Expect = 3e-08
Identities = 38/138 (27%), Positives = 63/138 (45%), Gaps = 4/138 (2%)
Query: 10 ELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVG 69
E + + RVL+VG G+G E+ KNL+L G + ++D + + + QFL + VG
Sbjct: 29 EAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVG 88
Query: 70 RSKAQVAKESVLQFYPKANI-VAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRM 128
R++A+ + E P ++ V D P+ FF QF V +R V+++
Sbjct: 89 RNRAEASLERAQNLNPMVDVKVDTEDIEKKPE---SFFTQFDAVCLTCCSRDVIVKVDQI 145
Query: 129 CLAADVPLIESGTAGYLG 146
C + GY G
Sbjct: 146 CHKNSIKFFTGDAFGYHG 163
>gi|66363686 NEDD8 activating enzyme E1 subunit 1 isoform b [Homo
sapiens]
Length = 528
Score = 50.8 bits (120), Expect = 4e-06
Identities = 35/142 (24%), Positives = 65/142 (45%), Gaps = 1/142 (0%)
Query: 13 EAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSK 72
EA+ V ++ A G E+LKNLVL G +ID + + + F Q+ +G+++
Sbjct: 20 EALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNR 79
Query: 73 AQVAKESVLQFYPKANIVAYHDSIMN-PDYNVEFFRQFILVMNALDNRAARNHVNRMCLA 131
A+ A E + + + +S N D + FF +F +V+ + + +
Sbjct: 80 AEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVATQLPESTSLRLADVLWN 139
Query: 132 ADVPLIESGTAGYLGQVTTIKK 153
+ +PL+ T G +G + I K
Sbjct: 140 SQIPLLICRTYGLVGYMRIIIK 161
>gi|4502169 NEDD8 activating enzyme E1 subunit 1 isoform a [Homo
sapiens]
Length = 534
Score = 50.8 bits (120), Expect = 4e-06
Identities = 35/142 (24%), Positives = 65/142 (45%), Gaps = 1/142 (0%)
Query: 13 EAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSK 72
EA+ V ++ A G E+LKNLVL G +ID + + + F Q+ +G+++
Sbjct: 26 EALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNR 85
Query: 73 AQVAKESVLQFYPKANIVAYHDSIMN-PDYNVEFFRQFILVMNALDNRAARNHVNRMCLA 131
A+ A E + + + +S N D + FF +F +V+ + + +
Sbjct: 86 AEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVATQLPESTSLRLADVLWN 145
Query: 132 ADVPLIESGTAGYLGQVTTIKK 153
+ +PL+ T G +G + I K
Sbjct: 146 SQIPLLICRTYGLVGYMRIIIK 167
>gi|222144229 APG7 autophagy 7-like isoform c [Homo sapiens]
Length = 623
Score = 47.8 bits (112), Expect = 3e-05
Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 3/96 (3%)
Query: 13 EAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHV---G 69
+ V + L++GAG +GC + + L+ G HI +D I SN RQ L++ + G
Sbjct: 312 DKVVSVKCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGG 371
Query: 70 RSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEF 105
+ KA A + + + +P N ++ SI P + V F
Sbjct: 372 KPKALAAADRLQKIFPGVNARGFNMSIPMPGHPVNF 407
>gi|222144227 APG7 autophagy 7-like isoform b [Homo sapiens]
Length = 676
Score = 47.8 bits (112), Expect = 3e-05
Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 3/96 (3%)
Query: 13 EAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHV---G 69
+ V + L++GAG +GC + + L+ G HI +D I SN RQ L++ + G
Sbjct: 351 DKVVSVKCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGG 410
Query: 70 RSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEF 105
+ KA A + + + +P N ++ SI P + V F
Sbjct: 411 KPKALAAADRLQKIFPGVNARGFNMSIPMPGHPVNF 446
>gi|5453668 APG7 autophagy 7-like isoform a [Homo sapiens]
Length = 703
Score = 47.8 bits (112), Expect = 3e-05
Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 3/96 (3%)
Query: 13 EAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHV---G 69
+ V + L++GAG +GC + + L+ G HI +D I SN RQ L++ + G
Sbjct: 351 DKVVSVKCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGG 410
Query: 70 RSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEF 105
+ KA A + + + +P N ++ SI P + V F
Sbjct: 411 KPKALAAADRLQKIFPGVNARGFNMSIPMPGHPVNF 446
>gi|195976782 Paf1/RNA polymerase II complex component [Homo
sapiens]
Length = 710
Score = 39.7 bits (91), Expect = 0.009
Identities = 30/99 (30%), Positives = 50/99 (50%), Gaps = 18/99 (18%)
Query: 552 EKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNNADVS------- 604
EK G + + A K+ ++GS D + S+A E+ +V DS+ SS+++D S
Sbjct: 121 EKKGTMKKQ-ANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFH 179
Query: 605 ----------EEERSRKRKLDEKENLSAKRSRIEQKEEL 633
EE+R+R ++ EKE +RIE++E L
Sbjct: 180 DGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVL 218
>gi|60302875 shugoshin-like 1 isoform A1 [Homo sapiens]
Length = 527
Score = 39.3 bits (90), Expect = 0.011
Identities = 44/173 (25%), Positives = 69/173 (39%), Gaps = 26/173 (15%)
Query: 481 QIEDG-----KGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHS 535
QIED + T+ + + GE ++ ++ +R+ + + Q + L + S
Sbjct: 156 QIEDQIPTIPQDTLGVDFDSGEAKSTDNVLPRTVSVRSSLKKHCNSICQ-FDSLDDFETS 214
Query: 536 EDLGKDVEFEVVG--------DAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDV 587
GK EFE VG PE V A +K N S QP T T ++D
Sbjct: 215 HLAGKSFEFERVGFLDPLVNMHIPENV-QHNACQWSKDQVNLSPKLIQPGTFTKTKED-- 271
Query: 588 LIVDSDEEDSSNNADVSEEERSRKRKLDE---------KENLSAKRSRIEQKE 631
++ E+ S D E +R KRK + KEN S + + QK+
Sbjct: 272 ILESKSEQTKSKQRDTQERKREEKRKANRRKSKRMSKYKENKSENKKTVPQKK 324
>gi|60302870 shugoshin-like 1 isoform A2 [Homo sapiens]
Length = 561
Score = 39.3 bits (90), Expect = 0.011
Identities = 44/173 (25%), Positives = 69/173 (39%), Gaps = 26/173 (15%)
Query: 481 QIEDG-----KGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHS 535
QIED + T+ + + GE ++ ++ +R+ + + Q + L + S
Sbjct: 156 QIEDQIPTIPQDTLGVDFDSGEAKSTDNVLPRTVSVRSSLKKHCNSICQ-FDSLDDFETS 214
Query: 536 EDLGKDVEFEVVG--------DAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDV 587
GK EFE VG PE V A +K N S QP T T ++D
Sbjct: 215 HLAGKSFEFERVGFLDPLVNMHIPENV-QHNACQWSKDQVNLSPKLIQPGTFTKTKED-- 271
Query: 588 LIVDSDEEDSSNNADVSEEERSRKRKLDE---------KENLSAKRSRIEQKE 631
++ E+ S D E +R KRK + KEN S + + QK+
Sbjct: 272 ILESKSEQTKSKQRDTQERKREEKRKANRRKSKRMSKYKENKSENKKTVPQKK 324
>gi|45505139 phosphoinositide-3-kinase adaptor protein 1 [Homo
sapiens]
Length = 805
Score = 38.9 bits (89), Expect = 0.015
Identities = 41/154 (26%), Positives = 61/154 (39%), Gaps = 7/154 (4%)
Query: 461 VLTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGET---EANNHKKLSEFGIRNGSRL 517
++TLQ+++ K +V D + K L + E+ + N K+L + R
Sbjct: 608 LITLQEQV---KLGIVNVDEAVLHFKEWQLNQKKRSESFRFQQENLKRLRDSITRRQREK 664
Query: 518 QADDFLQDYTLLINILHSEDLGKDVEFEVVGDAPEK-VGPKQAEDAAKSITNGSDDGAQP 576
Q D + + I HS+ L VEF V P K V P + E S
Sbjct: 665 QKSGKQTDLEITVPIRHSQHLPAKVEFGVYESGPRKSVIPPRTELRRGDWKTDSTSSTAS 724
Query: 577 STSTAQEQDDVLIVDSDEEDSSNNADVSEEERSR 610
STS +L V S E + + +V E RSR
Sbjct: 725 STSNRSSTRSLLSVSSGMEGDNEDNEVPEVTRSR 758
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 38.5 bits (88), Expect = 0.019
Identities = 39/163 (23%), Positives = 72/163 (44%), Gaps = 20/163 (12%)
Query: 486 KGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGKD-VEF 544
K ++LI G +ANN K L + + S+L + L+++ D+ +D +E
Sbjct: 1028 KNSLLIGLSTGLFDANNPKMLRTCSLPDLSKL--------FRTLMDVPTVGDVRQDNLEI 1079
Query: 545 EVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTA---------QEQDDVLIVDSDEE 595
+ + D K GP +ED T+ Q S E+++ ++ +SD E
Sbjct: 1080 DEIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVE 1139
Query: 596 DSSNNADVSEEE--RSRKRKLDEKENLSAKRSRIEQKEELDDV 636
++N DV++E+ S + L+E+ + I + E D V
Sbjct: 1140 PTANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSV 1182
>gi|17975763 myelin transcription factor 1 [Homo sapiens]
Length = 1121
Score = 37.7 bits (86), Expect = 0.033
Identities = 22/93 (23%), Positives = 45/93 (48%), Gaps = 6/93 (6%)
Query: 545 EVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNNADVS 604
EV + + + P+ EDAA S++ ++ + E++D + +EE+ + +
Sbjct: 226 EVTTERSQDLCPQSLEDAA------SEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEE 279
Query: 605 EEERSRKRKLDEKENLSAKRSRIEQKEELDDVI 637
EEE + + +E+E + E++E DVI
Sbjct: 280 EEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVI 312
>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
Length = 3230
Score = 37.7 bits (86), Expect = 0.033
Identities = 41/161 (25%), Positives = 76/161 (47%), Gaps = 19/161 (11%)
Query: 477 APDVQIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYT--LLINILH 534
A + + ED + TI + E+ E E ++ +LSE R G L ++ LQ Y
Sbjct: 405 ANEEEAEDEEDTIA-AEEQLEGEVDHAMELSELA-REGE-LSMEELLQQYAGAYAPGSGS 461
Query: 535 SEDLGKDVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDE 594
SED +D E + E GP +AE+ + ++ D + +++++D + E
Sbjct: 462 SEDEDED-EVDANSSDCEPEGPVEAEEPPQEDSSSQSDSVE---DRSEDEED----EHSE 513
Query: 595 EDSSNNADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDD 635
E+ ++ + SEE S E+ + +S+ +++EE DD
Sbjct: 514 EEETSGSSASEESES------EESEDAQSQSQADEEEEDDD 548
>gi|117938268 E2F-associated phosphoprotein [Homo sapiens]
Length = 285
Score = 35.8 bits (81), Expect = 0.12
Identities = 25/87 (28%), Positives = 42/87 (48%), Gaps = 3/87 (3%)
Query: 535 SEDLGKDVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDG-AQPSTSTAQEQDDVLIVDSD 593
SE +D EFE +A K ED S+ GS G + +T+ + DD+ DSD
Sbjct: 53 SESSSED-EFEKEMEAELNSTMKTMEDKLSSLGTGSSSGNGKVATAPTRYYDDIYF-DSD 110
Query: 594 EEDSSNNADVSEEERSRKRKLDEKENL 620
ED V+++++ ++ K+ + L
Sbjct: 111 SEDEDRAVQVTKKKKKKQHKIPTNDEL 137
>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
Length = 282
Score = 35.4 bits (80), Expect = 0.16
Identities = 27/98 (27%), Positives = 46/98 (46%), Gaps = 4/98 (4%)
Query: 541 DVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDE---EDS 597
+V+ E + DA EK G K+ E A + N +D + +E+ + D DE ED
Sbjct: 99 EVKEENIEDATEKGGEKK-EAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDG 157
Query: 598 SNNADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDD 635
+ + +E+ K K D K+ K + + KE+ +D
Sbjct: 158 KEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGED 195
Score = 32.3 bits (72), Expect = 1.4
Identities = 23/84 (27%), Positives = 32/84 (38%), Gaps = 4/84 (4%)
Query: 549 DAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNNADVSEEER 608
DA EK K+ ED +DG + +E+D D E + +E +
Sbjct: 169 DAKEKEDGKKGEDGK----GNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGK 224
Query: 609 SRKRKLDEKENLSAKRSRIEQKEE 632
K K DEKE K +EE
Sbjct: 225 DVKVKEDEKEREDGKEDEGGNEEE 248
>gi|55769548 PHD finger protein 14 isoform 2 [Homo sapiens]
Length = 888
Score = 35.4 bits (80), Expect = 0.16
Identities = 26/98 (26%), Positives = 51/98 (52%), Gaps = 3/98 (3%)
Query: 537 DLGKDVEFEVVGDAPEKVGPKQ-AEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEE 595
D D +F+V GDA + G +EDA+K GS ++ + + +D+ + + +
Sbjct: 24 DSSDDSDFKV-GDASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLK 82
Query: 596 DSSNNADVSEEERSRK-RKLDEKENLSAKRSRIEQKEE 632
+S+ +S E++ K K +E+EN R + E+++E
Sbjct: 83 NSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKE 120
>gi|55769550 PHD finger protein 14 isoform 1 [Homo sapiens]
Length = 948
Score = 35.4 bits (80), Expect = 0.16
Identities = 26/98 (26%), Positives = 51/98 (52%), Gaps = 3/98 (3%)
Query: 537 DLGKDVEFEVVGDAPEKVGPKQ-AEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEE 595
D D +F+V GDA + G +EDA+K GS ++ + + +D+ + + +
Sbjct: 24 DSSDDSDFKV-GDASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLK 82
Query: 596 DSSNNADVSEEERSRK-RKLDEKENLSAKRSRIEQKEE 632
+S+ +S E++ K K +E+EN R + E+++E
Sbjct: 83 NSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKE 120
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,168,889
Number of Sequences: 37866
Number of extensions: 1117844
Number of successful extensions: 6652
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 140
Number of HSP's that attempted gapping in prelim test: 5905
Number of HSP's gapped (non-prelim): 599
length of query: 640
length of database: 18,247,518
effective HSP length: 109
effective length of query: 531
effective length of database: 14,120,124
effective search space: 7497785844
effective search space used: 7497785844
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.