Search of human proteins with 4885259

Search of human proteins with 4885259

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4885259 myostatin [Homo sapiens]
         (375 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4885259 myostatin [Homo sapiens]                                   781   0.0  
gi|5031613 growth differentiation factor 11 precursor [Homo sapi...   486   e-137
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]      125   5e-29
gi|4507465 transforming growth factor, beta 3 [Homo sapiens]          117   1e-26
gi|4504699 inhibin beta A precursor [Homo sapiens]                    108   1e-23
gi|63025222 transforming growth factor, beta 1 [Homo sapiens]         105   7e-23
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa...   102   7e-22
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi...   100   2e-21
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi...    99   8e-21
gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ...    94   2e-19
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]       94   3e-19
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap...    93   4e-19
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa...    87   2e-17
gi|61835232 growth differentiation factor 7 preproprotein [Homo ...    87   3e-17
gi|145611428 bone morphogenetic protein 8A [Homo sapiens]              87   3e-17
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]           86   5e-17
gi|48475062 growth differentiation factor 6 precursor [Homo sapi...    85   9e-17
gi|10190670 growth differentiation factor 3 precursor [Homo sapi...    85   9e-17
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa...    85   1e-16
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa...    85   1e-16
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa...    85   1e-16
gi|4503969 growth differentiation factor 5 preproprotein [Homo s...    84   3e-16
gi|13899338 activin beta E [Homo sapiens]                              83   4e-16
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap...    81   1e-15
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa...    76   4e-14
gi|110349792 growth differentiation factor 1 [Homo sapiens]            75   1e-13
gi|7705308 growth differentiation factor 2 [Homo sapiens]              72   1e-12
gi|4826740 growth differentiation factor 10 precursor [Homo sapi...    71   1e-12
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]      65   8e-11
gi|222352098 nodal precursor [Homo sapiens]                            64   2e-10

>gi|4885259 myostatin [Homo sapiens]
          Length = 375

 Score =  781 bits (2018), Expect = 0.0
 Identities = 375/375 (100%), Positives = 375/375 (100%)

Query: 1   MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQI 60
           MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQI
Sbjct: 1   MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQI 60

Query: 61  LSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIIT 120
           LSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIIT
Sbjct: 61  LSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIIT 120

Query: 121 MPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPM 180
           MPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPM
Sbjct: 121 MPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPM 180

Query: 181 KDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVT 240
           KDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVT
Sbjct: 181 KDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVT 240

Query: 241 FPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIA 300
           FPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIA
Sbjct: 241 FPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIA 300

Query: 301 PKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQII 360
           PKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQII
Sbjct: 301 PKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQII 360

Query: 361 YGKIPAMVVDRCGCS 375
           YGKIPAMVVDRCGCS
Sbjct: 361 YGKIPAMVVDRCGCS 375


>gi|5031613 growth differentiation factor 11 precursor [Homo
           sapiens]
          Length = 407

 Score =  486 bits (1250), Expect = e-137
 Identities = 227/347 (65%), Positives = 279/347 (80%), Gaps = 11/347 (3%)

Query: 39  CNACTWRQNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQR 98
           C  C WRQ+++  R+E+IK QILSKLRL+ APNIS++V++QLLPKAPPL++++D +D Q 
Sbjct: 62  CPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQG 121

Query: 99  DD-SSDGSLEDDDYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLW 157
           D    +  LE+D+YHATTET+I+M  E+D  +Q DG P CC F FS K+ + KV+KAQLW
Sbjct: 122 DALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQLW 181

Query: 158 IYLRPVETPTTVFVQILRLIKPMKD---------GTRYTGIRSLKLDMNPGTGIWQSIDV 208
           +YLRPV  P TV++QILRL KP+           G R+  IRSLK++++  +G WQSID 
Sbjct: 182 VYLRPVPRPATVYLQILRL-KPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDF 240

Query: 209 KTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDF 268
           K VL +W +QP+SN GIEI A D +G DLAVT  GPG +GL+PF+E++V +  KRSRR+ 
Sbjct: 241 KQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNL 300

Query: 269 GLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVH 328
           GLDCDEHS+ESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSG+CE++F+QKYPHTHLV 
Sbjct: 301 GLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQ 360

Query: 329 QANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS 375
           QANPRGSAGPCCTPTKMSPINMLYFN K+QIIYGKIP MVVDRCGCS
Sbjct: 361 QANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS 407


>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
          Length = 407

 Score =  125 bits (315), Expect = 5e-29
 Identities = 103/349 (29%), Positives = 166/349 (47%), Gaps = 42/349 (12%)

Query: 53  IEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYH 112
           +EA+K  ILS+L++   PNI+  V     PKA  +  L   +  +  +     +   D H
Sbjct: 75  LEAVKRHILSRLQMRGRPNITHAV-----PKAAMVTALRKLHAGKVREDGRVEIPHLDGH 129

Query: 113 AT--------TETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLR--- 161
           A+           II+   E+D L     + +  FF  +   Q   VV+A LW+YL+   
Sbjct: 130 ASPGADGQERVSEIISF-AETDGL--ASSRVRLYFFISNEGNQNLFVVQASLWLYLKLLP 186

Query: 162 -PVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPE 220
             +E  +   V++    +    G R+  +   ++D+      W +  +   +Q   ++ E
Sbjct: 187 YVLEKGSRRKVRVKVYFQEQGHGDRWNMVEK-RVDLKRSG--WHTFPLTEAIQALFERGE 243

Query: 221 SNLGIEIKALDENGHDLAVT--FPGPGEDGLNPFLEVKVTDTPKRSR-RDFGLDCDEHST 277
             L ++++   ++  +LAV   F  PGE+   PF+ V+      R R R  GL+CD  + 
Sbjct: 244 RRLNLDVQC--DSCQELAVVPVFVDPGEESHRPFVVVQARLGDSRHRIRKRGLECDGRT- 300

Query: 278 ESRCCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGECEFVFLQKYP------HTHLVHQA 330
            + CCR    +DF   GW DWIIAP  Y  NYC G C   +L   P      HT +V+Q 
Sbjct: 301 -NLCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCP-AYLAGVPGSASSFHTAVVNQY 358

Query: 331 NPRG----SAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS 375
             RG    +   CC PTK+S ++MLYF+ +  I+   +P M+V+ CGC+
Sbjct: 359 RMRGLNPGTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGCA 407


>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
          Length = 412

 Score =  117 bits (294), Expect = 1e-26
 Identities = 102/381 (26%), Positives = 169/381 (44%), Gaps = 58/381 (15%)

Query: 49  KSSRIEAIKIQILSKLRLETAPN--ISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSL 106
           K  R+EAI+ QILSKLRL + P   +   V  Q+L      REL+++   +R++      
Sbjct: 36  KKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQEN 95

Query: 107 EDDDYHATT----ETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRP 162
            + +Y+A      + I  +   ++  +   G     F    S ++ N+    +    +  
Sbjct: 96  TESEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLR 155

Query: 163 VETPTTVF----VQILRLIKPMKD--GTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWL 216
           V  P++      +++ ++++P +     RY G ++L      GT  W S DV   ++ WL
Sbjct: 156 VPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGKNLP---TRGTAEWLSFDVTDTVREWL 212

Query: 217 KQPESNLGIEIKA------------LDENGHD-LAVTFPGPG----------------ED 247
            + ESNLG+EI              + EN H+ + + F G                  +D
Sbjct: 213 LRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKD 272

Query: 248 GLNPFLEVKVT-----DTP----KRSRRDFGLDCDEHSTESRCCRYPLTVDF-EAFGWDW 297
             NP L + +      D P    +R +R    +    + E  CC  PL +DF +  GW W
Sbjct: 273 HHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKW 332

Query: 298 IIAPKRYKANYCSGECEFVFLQKYPHT---HLVHQANPRGSAGPCCTPTKMSPINMLYFN 354
           +  PK Y AN+CSG C ++      H+    L +  NP  SA PCC P  + P+ +LY+ 
Sbjct: 333 VHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYV 392

Query: 355 GKEQIIYGKIPAMVVDRCGCS 375
           G+   +  ++  MVV  C CS
Sbjct: 393 GRTPKV-EQLSNMVVKSCKCS 412


>gi|4504699 inhibin beta A precursor [Homo sapiens]
          Length = 426

 Score =  108 bits (269), Expect = 1e-23
 Identities = 101/386 (26%), Positives = 165/386 (42%), Gaps = 65/386 (16%)

Query: 47  NTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSL 106
           N++   +EA+K  IL+ L L+  P++++ V     PKA  L  +   +  +  ++    +
Sbjct: 49  NSQPEMVEAVKKHILNMLHLKKRPDVTQPV-----PKAALLNAIRKLHVGKVGENGYVEI 103

Query: 107 EDD-DYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVV-KAQLWIYLRPVE 164
           EDD    A    ++   +E     +     K   F+ S +     VV +A++W++L+  +
Sbjct: 104 EDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPK 163

Query: 165 TPTTVFVQILRLIKPMK--DGTRYTGIRSLKLDM--------------NPGTGIWQSIDV 208
              T     +RL +  K   G+  TG  + ++ +              +     W    V
Sbjct: 164 ANRTRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPV 223

Query: 209 KTVLQNWLKQPESNLGIEI--KALDENGHDLAVTFP-------------GPGEDGLN--- 250
            + +Q  L Q +S+L + I  +   E+G  L +                G GE G     
Sbjct: 224 SSSIQRLLDQGKSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADE 283

Query: 251 -------PFLEVKVT---DTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGW-DWII 299
                  PFL ++     D P R RR  GL+CD     + CC+    V F+  GW DWII
Sbjct: 284 EKEQSHRPFLMLQARQSEDHPHRRRRR-GLECD--GKVNICCKKQFFVSFKDIGWNDWII 340

Query: 300 APKRYKANYCSGEC----------EFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPIN 349
           AP  Y ANYC GEC             F     + + +   +P  +   CC PTK+ P++
Sbjct: 341 APSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMS 400

Query: 350 MLYFNGKEQIIYGKIPAMVVDRCGCS 375
           MLY++  + II   I  M+V+ CGCS
Sbjct: 401 MLYYDDGQNIIKKDIQNMIVEECGCS 426


>gi|63025222 transforming growth factor, beta 1 [Homo sapiens]
          Length = 390

 Score =  105 bits (262), Expect = 7e-23
 Identities = 99/359 (27%), Positives = 153/359 (42%), Gaps = 42/359 (11%)

Query: 49  KSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLED 108
           K  RIEAI+ QILSKLRL + P+  +      +P  P    ++  Y+  RD  +  S E 
Sbjct: 42  KRKRIEAIRGQILSKLRLASPPSQGE------VPPGPLPEAVLALYNSTRDRVAGESAEP 95

Query: 109 D-----DYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIY---L 160
           +     DY+A   T + M    + +     +     + F +  +  + V   + +    L
Sbjct: 96  EPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAEL 155

Query: 161 RPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPE 220
           R +     V   +    K   +  RY   R L    +P    W S DV  V++ WL +  
Sbjct: 156 RLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPE---WLSFDVTGVVRQWLSRGG 212

Query: 221 SNLGIEIKA---LDENGHDLAVTFPG-----PGE----DGLN-PFLEVKVTDTPK----- 262
              G  + A    D   + L V   G      G+     G+N PFL +  T   +     
Sbjct: 213 EIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQ 272

Query: 263 --RSRRDFGLDCDEHSTESRCCRYPLTVDFEA-FGWDWIIAPKRYKANYCSGECEFVFLQ 319
             R RR    +    STE  CC   L +DF    GW WI  PK Y AN+C G C +++  
Sbjct: 273 SSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSL 332

Query: 320 KYPHTH---LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS 375
              ++    L +Q NP  SA PCC P  + P+ ++Y+ G++  +  ++  M+V  C CS
Sbjct: 333 DTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKV-EQLSNMIVRSCKCS 390


>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
           sapiens]
          Length = 414

 Score =  102 bits (253), Expect = 7e-22
 Identities = 94/387 (24%), Positives = 157/387 (40%), Gaps = 71/387 (18%)

Query: 52  RIEAIKIQILSKLRLETAPNI---SKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLED 108
           RIEAI+ QILSKL+L + P      ++V  +++      R+L+ +   +R  + +    D
Sbjct: 36  RIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSD 95

Query: 109 DDYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYN---------KVVKAQLWIY 159
           ++Y+A     I MP    F    +  P   +  +   ++++          +VKA+  ++
Sbjct: 96  EEYYAKEVYKIDMPP---FFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF 152

Query: 160 L--RPVETPTTVFVQILRLIKPMKDGT----RYTGIRSLKLDMNPGTGIWQSIDVKTVLQ 213
               P        +++ +++K  KD T    RY   + +K       G W S DV   + 
Sbjct: 153 RLQNPKARVPEQRIELYQILKS-KDLTSPTQRYIDSKVVK---TRAEGEWLSFDVTDAVH 208

Query: 214 NWLKQPESNLGIEIKA--------------LDENGHDLAVTFPG---------------- 243
            WL   + NLG +I                +     +L   F G                
Sbjct: 209 EWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIK 268

Query: 244 ---PGEDGLNPFL--------EVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEA 292
                  G  P L         ++   T +R +R         + +  CC  PL +DF+ 
Sbjct: 269 STRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKR 328

Query: 293 -FGWDWIIAPKRYKANYCSGECEFVFLQKYPHTH---LVHQANPRGSAGPCCTPTKMSPI 348
             GW WI  PK Y AN+C+G C +++     H+    L +  NP  SA PCC    + P+
Sbjct: 329 DLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPL 388

Query: 349 NMLYFNGKEQIIYGKIPAMVVDRCGCS 375
            +LY+ GK   I  ++  M+V  C CS
Sbjct: 389 TILYYIGKTPKI-EQLSNMIVKSCKCS 414


>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
           sapiens]
          Length = 513

 Score =  100 bits (250), Expect = 2e-21
 Identities = 66/208 (31%), Positives = 90/208 (43%), Gaps = 36/208 (17%)

Query: 203 WQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPG-PGEDG---LNPFL----- 253
           W   D+      W+  P+ N+G+++  +  +G  +     G  G DG     PF+     
Sbjct: 305 WLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFK 364

Query: 254 --EVKVTDTPKRSRR------------------DFGLDCDEHSTESRCCRYPLTVDFEAF 293
             EV V  T   S R                      D +    ++ C ++ L V F+  
Sbjct: 365 VSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQDL 424

Query: 294 GW-DWIIAPKRYKANYCSGECEFVFLQKYPHTH------LVHQANPRGSAGPCCTPTKMS 346
           GW DWIIAPK Y ANYC GEC F        T+      LVH  NP     PCC PTK++
Sbjct: 425 GWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLN 484

Query: 347 PINMLYFNGKEQIIYGKIPAMVVDRCGC 374
            I++LYF+    +I  K   MVV  CGC
Sbjct: 485 AISVLYFDDNSNVILKKYRNMVVRACGC 512


>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
           sapiens]
          Length = 396

 Score = 98.6 bits (244), Expect = 8e-21
 Identities = 97/368 (26%), Positives = 148/368 (40%), Gaps = 68/368 (18%)

Query: 53  IEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGS------L 106
           +   ++++LS   L+  P  S+D +       PP   ++D Y  +R     GS      L
Sbjct: 50  LSEFELRLLSMFGLKQRPTPSRDAV------VPPY--MLDLY--RRHSGQPGSPAPDHRL 99

Query: 107 EDDDYHATTETIITMPTESDFLMQVDGKP-KCCFFKFSSKIQYNKVVKAQLWIYLRPVET 165
           E     A T          + L +  GK  +  FF  SS      +  A+L ++   ++ 
Sbjct: 100 ERAASRANTVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQD 159

Query: 166 P---TTVF---VQILRLIKPMKDGTRYTGIRSLKLDM-NPGTGIWQSIDVKTVLQNWLKQ 218
                + F   + I  +IKP    +++   R L   + N     W+S DV   +  W  Q
Sbjct: 160 ALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQ 219

Query: 219 PESNLGIEI-------------------KALDENGHD------LAVTFPGPGEDGLNPFL 253
             +N G  +                   ++L ++ H       L VTF   G DG    L
Sbjct: 220 GHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTF---GHDGKGHPL 276

Query: 254 EVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGE 312
             +     K  +R           +S C R+PL VDF   GW DWI+AP  Y A YC GE
Sbjct: 277 HKREKRQAKHKQRK--------RLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGE 328

Query: 313 CEFVFLQKYPHTH------LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPA 366
           C F        T+      LV+  N +     CC PT++S I+MLY +  E+++      
Sbjct: 329 CPFPLADHLNSTNHAIVQTLVNSVNSKIPKA-CCVPTELSAISMLYLDENEKVVLKNYQD 387

Query: 367 MVVDRCGC 374
           MVV+ CGC
Sbjct: 388 MVVEGCGC 395


>gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
           sapiens]
          Length = 442

 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 98/412 (23%), Positives = 162/412 (39%), Gaps = 93/412 (22%)

Query: 52  RIEAIKIQILSKLRLETAPNI---SKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLED 108
           RIEAI+ QILSKL+L + P      ++V  +++      R+L+ +   +R  + +    D
Sbjct: 36  RIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSD 95

Query: 109 DDYHA---------------TTETIITMPTES----------------DFLMQVDGKPKC 137
           ++Y+A               T   ++T P+ S                D +     +P  
Sbjct: 96  EEYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYF 155

Query: 138 CFFKFS-SKIQYN--KVVKAQLWIYL--RPVETPTTVFVQILRLIKPMKDGT----RYTG 188
              +F  S ++ N   +VKA+  ++    P        +++ +++K  KD T    RY  
Sbjct: 156 RIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKS-KDLTSPTQRYID 214

Query: 189 IRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKA--------------LDENG 234
            + +K       G W S DV   +  WL   + NLG +I                +    
Sbjct: 215 SKVVK---TRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKS 271

Query: 235 HDLAVTFPG-------------------PGEDGLNPFL--------EVKVTDTPKRSRRD 267
            +L   F G                       G  P L         ++   T +R +R 
Sbjct: 272 EELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRA 331

Query: 268 FGLDCDEHSTESRCCRYPLTVDFEA-FGWDWIIAPKRYKANYCSGECEFVFLQKYPHTH- 325
                   + +  CC  PL +DF+   GW WI  PK Y AN+C+G C +++     H+  
Sbjct: 332 LDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRV 391

Query: 326 --LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS 375
             L +  NP  SA PCC    + P+ +LY+ GK   I  ++  M+V  C CS
Sbjct: 392 LSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNMIVKSCKCS 442


>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
          Length = 431

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 63/208 (30%), Positives = 87/208 (41%), Gaps = 36/208 (17%)

Query: 203 WQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPG----PGEDGLNPFLEV--K 256
           W   D+     +W+  P  NLG+++     +G  +     G     G     PF+    K
Sbjct: 223 WLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFK 282

Query: 257 VTDTPKRSRRDFGLD---------------------CDEHSTESR--CCRYPLTVDFEAF 293
            T+   RS R  G                        +  S++ R  C ++ L V F   
Sbjct: 283 ATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDL 342

Query: 294 GW-DWIIAPKRYKANYCSGECEFVFLQKYPHTH------LVHQANPRGSAGPCCTPTKMS 346
           GW DWIIAP+ Y A YC GEC F        T+      LVH  NP     PCC PT+++
Sbjct: 343 GWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLN 402

Query: 347 PINMLYFNGKEQIIYGKIPAMVVDRCGC 374
            I++LYF+    +I  K   MVV  CGC
Sbjct: 403 AISVLYFDDSSNVILKKYRNMVVRACGC 430


>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
           sapiens]
          Length = 454

 Score = 92.8 bits (229), Expect = 4e-19
 Identities = 62/207 (29%), Positives = 87/207 (42%), Gaps = 35/207 (16%)

Query: 203 WQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPG----PGEDGLNPFL----- 253
           W   D+     +W+  P++NLG+++ A   +G  + V   G     G     PF+     
Sbjct: 247 WLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFK 306

Query: 254 -------EVKVTDTPKRSRRDFGLDCDEHSTESR------------CCRYPLTVDFEAFG 294
                   V+  +  K   R+      + S  S             C ++ L V F   G
Sbjct: 307 ASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLG 366

Query: 295 W-DWIIAPKRYKANYCSGECEFVFLQKYPHTH------LVHQANPRGSAGPCCTPTKMSP 347
           W DWIIAP+ Y A YC GEC F        T+      LVH   P     PCC PTK++ 
Sbjct: 367 WQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNA 426

Query: 348 INMLYFNGKEQIIYGKIPAMVVDRCGC 374
           I++LYF+    +I  K   MVV  CGC
Sbjct: 427 ISVLYFDDSSNVILKKYRNMVVRSCGC 453


>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
           sapiens]
          Length = 402

 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 64/213 (30%), Positives = 89/213 (41%), Gaps = 46/213 (21%)

Query: 203 WQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGL---------NPFL 253
           W  +DV      WL +   +LG+ +    E+GH +      PG  GL          PF+
Sbjct: 194 WLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSV-----DPGLAGLLGQRAPRSQQPFV 248

Query: 254 EV--KVTDTPKRSRRDF---------------------GLDCDEHSTESR--CCRYPLTV 288
               + + +P R+ R                       G+  D H +  R  C R+ L V
Sbjct: 249 VTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQVCRRHELYV 308

Query: 289 DFEAFGW-DWIIAPKRYKANYCSGECEFVFLQKYPHTH------LVHQANPRGSAGPCCT 341
            F+  GW DW+IAP+ Y A YC GEC F        T+      LVH   P      CC 
Sbjct: 309 SFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACCA 368

Query: 342 PTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 374
           PTK+S  ++LY++    +I  K   MVV  CGC
Sbjct: 369 PTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401


>gi|61835232 growth differentiation factor 7 preproprotein [Homo
           sapiens]
          Length = 450

 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 41/103 (39%), Positives = 58/103 (56%), Gaps = 7/103 (6%)

Query: 279 SRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLQKYPHTH------LVHQAN 331
           SRC R PL VDF+  GWD WIIAP  Y+A +C G C+F        T+      L++   
Sbjct: 347 SRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMA 406

Query: 332 PRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 374
           P  +   CC P ++SPI++LY +    ++Y +   MVV+ CGC
Sbjct: 407 PDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGC 449


>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
          Length = 402

 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 92/365 (25%), Positives = 141/365 (38%), Gaps = 53/365 (14%)

Query: 56  IKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHAT- 114
           ++ +IL+ L L   P          LP + PL  L   + +  DD  DG+  +       
Sbjct: 44  VQREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAEQRLGRAD 103

Query: 115 -TETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVE--TPTTVFV 171
              + + M      L   +   K   F  +       V  A+  IY  P       T+ V
Sbjct: 104 LVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTLHV 163

Query: 172 QILRLIKPMKDGTRYTGIRSLKLD-MNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKAL 230
            + ++++  +   R + +  L L  +  G   W  +DV      WL +   +LG+ +   
Sbjct: 164 SMFQVVQ--EQSNRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVE 221

Query: 231 DENGHDLAVTFPGPGEDGL---------NPFLEV--KVTDTPKRSRRDF----------- 268
            E+GH +      PG  GL          PF+    + + +P R+ R             
Sbjct: 222 TEDGHSV-----DPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKS 276

Query: 269 ----------GLDCDEHSTESR--CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGECEF 315
                     G+  D   +  R  C R+ L V F+  GW DW+IAP+ Y A YC GEC F
Sbjct: 277 NELPQANRLPGIFDDVRGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSF 336

Query: 316 VFLQKYPHTH------LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVV 369
                   T+      LVH   P      CC PTK+S  ++LY++    +I  K   MVV
Sbjct: 337 PLDSCMNATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVV 396

Query: 370 DRCGC 374
             CGC
Sbjct: 397 KACGC 401


>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
          Length = 352

 Score = 85.9 bits (211), Expect = 5e-17
 Identities = 99/367 (26%), Positives = 145/367 (39%), Gaps = 66/367 (17%)

Query: 37  GLCNACTWR----QNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELID 92
           G C AC       ++ +   ++  K  IL KL L   P +++ V R  L  A      + 
Sbjct: 24  GQCPACGGPTLELESQRELLLDLAKRSILDKLHLTQRPTLNRPVSRAALRTALQHLHGVP 83

Query: 93  QYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYN--K 150
           Q          G+L +D+     E I    T    + Q         F FSS       +
Sbjct: 84  Q----------GALLEDNREQECEIISFAETGLSTINQTR-----LDFHFSSDRTAGDRE 128

Query: 151 VVKAQLWIYLR-PVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVK 209
           V +A L  +++ P  T  T+ V++L L           G  +  L +   T     +D  
Sbjct: 129 VQQASLMFFVQLPSNTTWTLKVRVLVL-----------GPHNTNLTL--ATQYLLEVDAS 175

Query: 210 TVLQNWLKQPESNLGIEIKALDENGH-DLAVTFPGP--------GEDGLNPFLEVKVTDT 260
                W + P   LG E +A    GH  L +   G         G     PF+  +V   
Sbjct: 176 ----GWHQLP---LGPEAQAACSQGHLTLELVLEGQVAQSSVILGGAAHRPFVAARVRVG 228

Query: 261 PKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGECEFVFLQ 319
            K      G+DC   S    CCR    VDF   GW DWII P+ Y  N+C G+C  + + 
Sbjct: 229 GKHQIHRRGIDCQGGSR--MCCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCP-LHIA 285

Query: 320 KYP------HTHLVHQANPRGSAGP-----CCTPTKMSPINMLYFNGKEQIIYGKIPAMV 368
             P      HT +++      +AG      CC PT   P+++LY++    I+   IP MV
Sbjct: 286 GMPGIAASFHTAVLNLLKANTAAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMV 345

Query: 369 VDRCGCS 375
           V+ CGCS
Sbjct: 346 VEACGCS 352


>gi|48475062 growth differentiation factor 6 precursor [Homo
           sapiens]
          Length = 455

 Score = 85.1 bits (209), Expect = 9e-17
 Identities = 39/102 (38%), Positives = 59/102 (57%), Gaps = 7/102 (6%)

Query: 280 RCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLQKYPHTH------LVHQANP 332
           RC + PL V+F+  GWD WIIAP  Y+A +C G C+F        T+      L++  +P
Sbjct: 353 RCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDP 412

Query: 333 RGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 374
             +   CC PTK++PI++LY +    ++Y +   MVV+ CGC
Sbjct: 413 GSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454


>gi|10190670 growth differentiation factor 3 precursor [Homo
           sapiens]
          Length = 364

 Score = 85.1 bits (209), Expect = 9e-17
 Identities = 60/182 (32%), Positives = 85/182 (46%), Gaps = 22/182 (12%)

Query: 211 VLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGED-------GLNPFLEVKVTDT--- 260
           V ++W   P  N G+ ++ L +   D  V F    ED        L+  L V   +    
Sbjct: 186 VAKDWNDNPRKNFGLFLEILVKEDRDSGVNFQP--EDTCARLRCSLHASLLVVTLNPDQC 243

Query: 261 -PKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFL 318
            P R RR   +   + S ++ C R+ L ++F   GW  WIIAPK + ANYC GEC F   
Sbjct: 244 HPSRKRRA-AIPVPKLSCKNLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLT 302

Query: 319 QKYPHTH------LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRC 372
                ++      L+H  +P       C PTK+SPI+MLY +  + +I      MVVD C
Sbjct: 303 ISLNSSNYAFMQALMHAVDPEIPQA-VCIPTKLSPISMLYQDNNDNVILRHYEDMVVDEC 361

Query: 373 GC 374
           GC
Sbjct: 362 GC 363


>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 64/196 (32%), Positives = 89/196 (45%), Gaps = 24/196 (12%)

Query: 203 WQSIDVKTVLQNWL--KQPESNLGIEIKALDEN----GHDLAVTFPGPGEDG----LNPF 252
           W++ DV   +  W   KQP   L IE+  L +     G  + ++   P   G    L P 
Sbjct: 212 WETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPL 271

Query: 253 LEVKVTDTPKRS---RRDFGLDCDEHSTESR-----CCRYPLTVDFEAFGW-DWIIAPKR 303
           L     D    +   RR        HS  +R     C R+ L VDF   GW DWI+AP  
Sbjct: 272 LVTFGHDGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPG 331

Query: 304 YKANYCSGECEFVFLQKYPHT-HLVHQA--NPRGSAGP--CCTPTKMSPINMLYFNGKEQ 358
           Y+A YC G+C F        T H + Q   N   S+ P  CC PT++S I+MLY +  ++
Sbjct: 332 YQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDK 391

Query: 359 IIYGKIPAMVVDRCGC 374
           ++      MVV+ CGC
Sbjct: 392 VVLKNYQEMVVEGCGC 407


>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 64/196 (32%), Positives = 89/196 (45%), Gaps = 24/196 (12%)

Query: 203 WQSIDVKTVLQNWL--KQPESNLGIEIKALDEN----GHDLAVTFPGPGEDG----LNPF 252
           W++ DV   +  W   KQP   L IE+  L +     G  + ++   P   G    L P 
Sbjct: 212 WETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPL 271

Query: 253 LEVKVTDTPKRS---RRDFGLDCDEHSTESR-----CCRYPLTVDFEAFGW-DWIIAPKR 303
           L     D    +   RR        HS  +R     C R+ L VDF   GW DWI+AP  
Sbjct: 272 LVTFGHDGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPG 331

Query: 304 YKANYCSGECEFVFLQKYPHT-HLVHQA--NPRGSAGP--CCTPTKMSPINMLYFNGKEQ 358
           Y+A YC G+C F        T H + Q   N   S+ P  CC PT++S I+MLY +  ++
Sbjct: 332 YQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDK 391

Query: 359 IIYGKIPAMVVDRCGC 374
           ++      MVV+ CGC
Sbjct: 392 VVLKNYQEMVVEGCGC 407


>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 64/196 (32%), Positives = 89/196 (45%), Gaps = 24/196 (12%)

Query: 203 WQSIDVKTVLQNWL--KQPESNLGIEIKALDEN----GHDLAVTFPGPGEDG----LNPF 252
           W++ DV   +  W   KQP   L IE+  L +     G  + ++   P   G    L P 
Sbjct: 212 WETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPL 271

Query: 253 LEVKVTDTPKRS---RRDFGLDCDEHSTESR-----CCRYPLTVDFEAFGW-DWIIAPKR 303
           L     D    +   RR        HS  +R     C R+ L VDF   GW DWI+AP  
Sbjct: 272 LVTFGHDGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPG 331

Query: 304 YKANYCSGECEFVFLQKYPHT-HLVHQA--NPRGSAGP--CCTPTKMSPINMLYFNGKEQ 358
           Y+A YC G+C F        T H + Q   N   S+ P  CC PT++S I+MLY +  ++
Sbjct: 332 YQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDK 391

Query: 359 IIYGKIPAMVVDRCGC 374
           ++      MVV+ CGC
Sbjct: 392 VVLKNYQEMVVEGCGC 407


>gi|4503969 growth differentiation factor 5 preproprotein [Homo
           sapiens]
          Length = 501

 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 39/104 (37%), Positives = 60/104 (57%), Gaps = 7/104 (6%)

Query: 278 ESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLQKYPHTH------LVHQA 330
           ++RC R  L V+F+  GWD WIIAP  Y+A +C G CEF        T+      L++  
Sbjct: 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSM 456

Query: 331 NPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 374
           +P  +   CC PT++SPI++L+ +    ++Y +   MVV+ CGC
Sbjct: 457 DPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGC 500


>gi|13899338 activin beta E [Homo sapiens]
          Length = 350

 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 90/339 (26%), Positives = 143/339 (42%), Gaps = 48/339 (14%)

Query: 53  IEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYH 112
           +E  K QIL  L L + P I+    +  L +A  LR L             GS+   +  
Sbjct: 44  LELAKQQILDGLHLTSRPRITHPPPQAALTRA--LRRL-----------QPGSVAPGN-- 88

Query: 113 ATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQ 172
              E +I+  T +D             F  S+   ++ +  A+LW+++ P   P T+ ++
Sbjct: 89  --GEEVISFATVTD---STSAYSSLLTFHLSTPRSHH-LYHARLWLHVLPT-LPGTLCLR 141

Query: 173 ILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDE 232
           I R   P +   R  G R+L  + +     W ++ + +      K     L ++ + L+ 
Sbjct: 142 IFRW-GPRR---RRQGSRTLLAEHHITNLGWHTLTLPSSGLRGEKSGVLKLQLDCRPLEG 197

Query: 233 NGHDLAVTFPGPGEDGLN------PFLEVKV-TDTPKRSRRDFGLDCDEHSTESRCCRYP 285
           N      T  G     L+      PFLE+K+  + P   R        E +T   CCR  
Sbjct: 198 NS-----TVTGQPRRLLDTAGHQQPFLELKIRANEPGAGRARRRTPTCEPATPL-CCRRD 251

Query: 286 LTVDFEAFGW-DWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQA--------NPRGSA 336
             VDF+  GW DWI+ P+ Y+ NYCSG+C              H A        NP  ++
Sbjct: 252 HYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPAS 311

Query: 337 GPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS 375
             CC PT   P+++LY +    ++   +P MVV+ CGCS
Sbjct: 312 TSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGCS 350


>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
           sapiens]
          Length = 424

 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 48/139 (34%), Positives = 66/139 (47%), Gaps = 15/139 (10%)

Query: 243 GPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWD-WIIAP 301
           GPGE+ L       + D+  R RR+        +  + C R PL +DF+  GWD WIIAP
Sbjct: 293 GPGEEALLQMRSNIIYDSTARIRRN--------AKGNYCKRTPLYIDFKEIGWDSWIIAP 344

Query: 302 KRYKANYCSGECEFVFLQKYPHTH------LVHQANPRGSAGPCCTPTKMSPINMLYFNG 355
             Y+A  C G C +   +    T       LVH  N + ++  CC PTK+ PI++LY + 
Sbjct: 345 PGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDK 404

Query: 356 KEQIIYGKIPAMVVDRCGC 374
                  K   M V  CGC
Sbjct: 405 GVVTYKFKYEGMAVSECGC 423


>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
           sapiens]
          Length = 472

 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 39/102 (38%), Positives = 54/102 (52%), Gaps = 8/102 (7%)

Query: 281 CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGECEFVFLQKY-PHTHLVHQANPR----- 333
           C R  L VDF   GW +WII+PK + A YCSG C+F   +   P  H   Q+  R     
Sbjct: 370 CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVV 429

Query: 334 -GSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 374
            G   PCC P KMS +++L+F+  + ++    P M V+ C C
Sbjct: 430 PGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471


>gi|110349792 growth differentiation factor 1 [Homo sapiens]
          Length = 372

 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 37/105 (35%), Positives = 53/105 (50%), Gaps = 11/105 (10%)

Query: 281 CCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVF----------LQKYPHTHLVHQ 329
           C    L V F   GW  W+IAP+ + ANYC G+C              L       L+H 
Sbjct: 267 CRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHA 326

Query: 330 ANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 374
           A P  +  PCC P ++SPI++L+F+  + ++  +   MVVD CGC
Sbjct: 327 AAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371


>gi|7705308 growth differentiation factor 2 [Homo sapiens]
          Length = 429

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 90/387 (23%), Positives = 149/387 (38%), Gaps = 82/387 (21%)

Query: 53  IEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYH 112
           +E +K+  L  L L   P+  K        +  P + +ID Y+    D S     +    
Sbjct: 59  LENVKVDFLRSLNLSGVPSQDKT-------RVEPPQYMIDLYNRYTSDKSTTPASNIVRS 111

Query: 113 ATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYL---RPVETPTTV 169
            + E  I++    DF  Q         F  S   ++ ++ +A+L +Y+     V+    +
Sbjct: 112 FSMEDAISITATEDFPFQ----KHILLFNISIP-RHEQITRAELRLYVSCQNHVDPSHDL 166

Query: 170 FVQILRLIKPMKDGT----RYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLK----QPES 221
              ++  I  + DGT      T  ++  +  +     W++++V + ++ W++    + ++
Sbjct: 167 KGSVV--IYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKN 224

Query: 222 NLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTP-------------------- 261
            L + +++  +    L ++ P PG   L PF  V   D                      
Sbjct: 225 KLEVTVESHRKGCDTLDISVP-PGSRNL-PFFVVFSNDHSSGTKETRLELREMISHEQES 282

Query: 262 --KRSRRDFGLDCDEHSTE-----------------------SRCCRYPLTVDFEAFGWD 296
             K+  +D   +  E S E                       S C +  L V+FE  GWD
Sbjct: 283 VLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWD 342

Query: 297 -WIIAPKRYKANYCSGECEFVFLQKYPHTH------LVHQANPRGSAGPCCTPTKMSPIN 349
            WIIAPK Y+A  C G C F        T       LVH   P      CC PTK+SPI+
Sbjct: 343 SWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPIS 402

Query: 350 MLYFN--GKEQIIYGKIPAMVVDRCGC 374
           +LY +  G   + Y     M V  CGC
Sbjct: 403 VLYKDDMGVPTLKY-HYEGMSVAECGC 428


>gi|4826740 growth differentiation factor 10 precursor [Homo
           sapiens]
          Length = 478

 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 38/102 (37%), Positives = 51/102 (50%), Gaps = 8/102 (7%)

Query: 281 CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGECEFVFLQKY-PHTHLVHQANPR----- 333
           C R  L VDF   GW +WII+PK + A YC+G CEF   +   P  H   Q+  R     
Sbjct: 376 CSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGII 435

Query: 334 -GSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 374
            G   PCC P KM+ + +L+ +    ++    P M VD C C
Sbjct: 436 PGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCAC 477


>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
          Length = 392

 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 41/142 (28%), Positives = 64/142 (45%), Gaps = 17/142 (11%)

Query: 248 GLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESR--------CCRYPLTVDFEAFGWD-WI 298
           G+  F+E +     +R+R+  G+  +  ++ S+        C  +P  + F   GWD WI
Sbjct: 252 GMEEFMERE--SLLRRTRQADGISAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWI 309

Query: 299 IAPKRYKANYCSGECEFVF---LQKYPHT---HLVHQANPRGSAGPCCTPTKMSPINMLY 352
           IAP  Y  NYC G C  V    L    H    +L++Q   +    P C P K  PI++L 
Sbjct: 310 IAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLM 369

Query: 353 FNGKEQIIYGKIPAMVVDRCGC 374
                 I+Y +   M+ + C C
Sbjct: 370 IEANGSILYKEYEGMIAESCTC 391


>gi|222352098 nodal precursor [Homo sapiens]
          Length = 347

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 36/102 (35%), Positives = 51/102 (50%), Gaps = 10/102 (9%)

Query: 281 CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGECEFVFLQKYPHTH------LVHQANPR 333
           C +    VDF   GW  WII PK+Y A  C GEC     +++  T+      L+ +  P 
Sbjct: 247 CRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPH 306

Query: 334 GSAGPCCTPTKMSPINMLYF-NGKEQIIYGKIPAMVVDRCGC 374
                CC P K  P++MLY  NG+  + + K   M+V+ CGC
Sbjct: 307 RVPSTCCAPVKTKPLSMLYVDNGRVLLDHHK--DMIVEECGC 346


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,551,825
Number of Sequences: 37866
Number of extensions: 706798
Number of successful extensions: 1643
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1522
Number of HSP's gapped (non-prelim): 53
length of query: 375
length of database: 18,247,518
effective HSP length: 104
effective length of query: 271
effective length of database: 14,309,454
effective search space: 3877862034
effective search space used: 3877862034
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.