BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens] (392 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens] 806 0.0 gi|4885261 growth differentiation factor 9 precursor [Homo sapiens] 164 1e-40 gi|48475062 growth differentiation factor 6 precursor [Homo sapi... 113 3e-25 gi|61835232 growth differentiation factor 7 preproprotein [Homo ... 112 6e-25 gi|4503969 growth differentiation factor 5 preproprotein [Homo s... 107 2e-23 gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi... 106 4e-23 gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap... 104 1e-22 gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa... 102 8e-22 gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa... 102 8e-22 gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa... 102 8e-22 gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi... 102 8e-22 gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens] 100 4e-21 gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap... 97 3e-20 gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa... 93 4e-19 gi|145611428 bone morphogenetic protein 8A [Homo sapiens] 92 8e-19 gi|10190670 growth differentiation factor 3 precursor [Homo sapi... 92 1e-18 gi|7705308 growth differentiation factor 2 [Homo sapiens] 91 2e-18 gi|110349792 growth differentiation factor 1 [Homo sapiens] 86 8e-17 gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa... 84 2e-16 gi|222352098 nodal precursor [Homo sapiens] 80 4e-15 gi|4826740 growth differentiation factor 10 precursor [Homo sapi... 78 2e-14 gi|5031613 growth differentiation factor 11 precursor [Homo sapi... 69 6e-12 gi|4885259 myostatin [Homo sapiens] 65 8e-11 gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens] 65 8e-11 gi|4504699 inhibin beta A precursor [Homo sapiens] 64 2e-10 gi|13899338 activin beta E [Homo sapiens] 63 5e-10 gi|153792495 growth differentiation factor 15 [Homo sapiens] 61 2e-09 gi|239757187 PREDICTED: similar to growth differentiation factor... 61 2e-09 gi|5031795 inhibin beta C chain preproprotein [Homo sapiens] 60 4e-09 gi|4507465 transforming growth factor, beta 3 [Homo sapiens] 53 5e-07 >gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens] Length = 392 Score = 806 bits (2083), Expect = 0.0 Identities = 392/392 (100%), Positives = 392/392 (100%) Query: 1 MVLLSILRILFLCELVLFMEHRAQMAEGGQSSIALLAEAPTLPLIEELLEESPGEQPRKP 60 MVLLSILRILFLCELVLFMEHRAQMAEGGQSSIALLAEAPTLPLIEELLEESPGEQPRKP Sbjct: 1 MVLLSILRILFLCELVLFMEHRAQMAEGGQSSIALLAEAPTLPLIEELLEESPGEQPRKP 60 Query: 61 RLLGHSLRYMLELYRRSADSHGHPRENRTIGATMVRLVKPLTSVARPHRGTWHIQILGFP 120 RLLGHSLRYMLELYRRSADSHGHPRENRTIGATMVRLVKPLTSVARPHRGTWHIQILGFP Sbjct: 61 RLLGHSLRYMLELYRRSADSHGHPRENRTIGATMVRLVKPLTSVARPHRGTWHIQILGFP 120 Query: 121 LRPNRGLYQLVRATVVYRHHLQLTRFNLSCHVEPWVQKNPTNHFPSSEGDSSKPSLMSNA 180 LRPNRGLYQLVRATVVYRHHLQLTRFNLSCHVEPWVQKNPTNHFPSSEGDSSKPSLMSNA Sbjct: 121 LRPNRGLYQLVRATVVYRHHLQLTRFNLSCHVEPWVQKNPTNHFPSSEGDSSKPSLMSNA 180 Query: 181 WKEMDITQLVQQRFWNNKGHRILRLRFMCQQQKDSGGLELWHGTSSLDIAFLLLYFNDTH 240 WKEMDITQLVQQRFWNNKGHRILRLRFMCQQQKDSGGLELWHGTSSLDIAFLLLYFNDTH Sbjct: 181 WKEMDITQLVQQRFWNNKGHRILRLRFMCQQQKDSGGLELWHGTSSLDIAFLLLYFNDTH 240 Query: 241 KSIRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTASSSKHSGPENNQCSLHPFQISF 300 KSIRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTASSSKHSGPENNQCSLHPFQISF Sbjct: 241 KSIRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTASSSKHSGPENNQCSLHPFQISF 300 Query: 301 RQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPY 360 RQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPY Sbjct: 301 RQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPY 360 Query: 361 KYVPISVLMIEANGSILYKEYEGMIAESCTCR 392 KYVPISVLMIEANGSILYKEYEGMIAESCTCR Sbjct: 361 KYVPISVLMIEANGSILYKEYEGMIAESCTCR 392 >gi|4885261 growth differentiation factor 9 precursor [Homo sapiens] Length = 454 Score = 164 bits (416), Expect = 1e-40 Identities = 138/439 (31%), Positives = 190/439 (43%), Gaps = 83/439 (18%) Query: 26 AEGGQSSIALLAE-------------------APTLPLIEELLEESPGEQPR-KPRLLGH 65 A GG++ IA AE A LP + ++L G PR +P Sbjct: 27 ASGGEAQIAASAELESGAMPWSLLQHIDERDRAGLLPALFKVLSVGRGGSPRLQPD--SR 84 Query: 66 SLRYMLELYRRSADSHGHPRENRTIGATMVRLVKPLTSVARPHRGTWHIQILGFPLRPNR 125 +L YM +LY+ A G P+ NR+ VRL P T H+ Q+ G L Sbjct: 85 ALHYMKKLYKTYATKEGIPKSNRSHLYNTVRLFTPCTR----HKQAPGDQVTGI-LPSVE 139 Query: 126 GLYQLVRATVVYRHHLQLTRFNLSCHV---------------EPWVQKNPTNHFPSSEGD 170 L+ L R T V + +N++ V EP P S Sbjct: 140 LLFNLDRITTVEHLLKSVLLYNINNSVSFSSAVKCVCNLMIKEPKSSSRTLGRAPYSFTF 199 Query: 171 SSKPSL-MSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQ-QKDSGGLELWHGTSSLD 228 +S+ + W ++D+T L+Q +NK + + F C + Q + + +L Sbjct: 200 NSQFEFGKKHKWIQIDVTSLLQPLVASNKRSIHMSINFTCMKDQLEHPSAQNGLFNMTLV 259 Query: 229 IAFLLLYFNDTHKSI--------------------RKAKFLPRGMEEFME-RESLLRRTR 267 L+LY NDT R P G E + R S R R Sbjct: 260 SPSLILYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAYPVGEEAAEDGRSSHHRHRR 319 Query: 268 QADGISAEVTASSSKHSGPEN--------------NQCSLHPFQISFRQLGWDHWIIAPP 313 + +S+E+ K GP + N+C LH F++SF QL WD+WI+AP Sbjct: 320 GQETVSSEL----KKPLGPASFNLSEYFRQFLLPQNECELHDFRLSFSQLKWDNWIVAPH 375 Query: 314 FYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEAN 373 Y P YCKG C R + SP H ++QN+I + +D SVPRPSCVP KY P+SVL IE + Sbjct: 376 RYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYSPLSVLTIEPD 435 Query: 374 GSILYKEYEGMIAESCTCR 392 GSI YKEYE MIA CTCR Sbjct: 436 GSIAYKEYEDMIATKCTCR 454 >gi|48475062 growth differentiation factor 6 precursor [Homo sapiens] Length = 455 Score = 113 bits (283), Expect = 3e-25 Identities = 52/120 (43%), Positives = 71/120 (59%) Query: 273 SAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGL 332 +A + +H +CS P ++F++LGWD WIIAP Y +C+G C LR L Sbjct: 336 TAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHL 395 Query: 333 NSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR 392 NHAIIQ L+N + S P CVP K PIS+L I+A +++YK+YE M+ ESC CR Sbjct: 396 EPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR 455 >gi|61835232 growth differentiation factor 7 preproprotein [Homo sapiens] Length = 450 Score = 112 bits (280), Expect = 6e-25 Identities = 54/134 (40%), Positives = 75/134 (55%), Gaps = 3/134 (2%) Query: 259 RESLLRRTRQADGISAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPN 318 R + L TR A G + H ++CS P + F++LGWD WIIAP Y Sbjct: 320 RRTALAGTRTAQGSGG---GAGRGHGRRGRSRCSRKPLHVDFKELGWDDWIIAPLDYEAY 376 Query: 319 YCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILY 378 +C+G C LR L NHAIIQ L+N + + P CVP + PIS+L I+A +++Y Sbjct: 377 HCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANNVVY 436 Query: 379 KEYEGMIAESCTCR 392 K+YE M+ E+C CR Sbjct: 437 KQYEDMVVEACGCR 450 >gi|4503969 growth differentiation factor 5 preproprotein [Homo sapiens] Length = 501 Score = 107 bits (266), Expect = 2e-23 Identities = 77/240 (32%), Positives = 113/240 (47%), Gaps = 14/240 (5%) Query: 160 PTNHFPSSEGD-SSKPSLMSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQQK-DSGG 217 P+ P+S D S P L + W+ DI +L R + N L L + + D G Sbjct: 269 PSGRQPASLLDVRSVPGLDGSGWEVFDIWKLF--RNFKNSAQLCLELEAWERGRAVDLRG 326 Query: 218 LELWHGTSSLDIAFLLLYFNDTHK-----SIRKAKFLPRGMEEFMERESLLRRTRQADGI 272 L + L L F T K + KA+ G ++ E L + R+ Sbjct: 327 LGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKAR---SGQDDKTVYEYLFSQRRKRRAP 383 Query: 273 SAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGL 332 A T + S +CS ++F+ +GWD WIIAP Y +C+G C LR L Sbjct: 384 LA--TRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHL 441 Query: 333 NSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR 392 NHA+IQ L+N + +S P CVP + PIS+L I++ +++YK+YE M+ ESC CR Sbjct: 442 EPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 >gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapiens] Length = 513 Score = 106 bits (264), Expect = 4e-23 Identities = 54/161 (33%), Positives = 83/161 (51%), Gaps = 6/161 (3%) Query: 231 FLLLYFNDTHKSIRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTASSSKHSGPENNQ 290 F++ +F + +R R ++S R T+ D A V+++S +S Sbjct: 358 FMVAFFKVSEVHVRTT----RSASSRRRQQSRNRSTQSQD--VARVSSASDYNSSELKTA 411 Query: 291 CSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQ 350 C H +SF+ LGW WIIAP Y NYC G C L +N+ NHAI+Q L++ + + Sbjct: 412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPE 471 Query: 351 SVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391 VP+P C P K ISVL + N +++ K+Y M+ +C C Sbjct: 472 YVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512 >gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sapiens] Length = 454 Score = 104 bits (260), Expect = 1e-22 Identities = 66/229 (28%), Positives = 104/229 (45%), Gaps = 18/229 (7%) Query: 170 DSSKPSLMSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQQKD-------SGGLELWH 222 D+ K + W DIT V W L L+ +C + D S GL Sbjct: 236 DTRKAQALDVGWLVFDIT--VTSNHWVINPQNNLGLQ-LCAETGDGRSINVKSAGLVGRQ 292 Query: 223 GTSSLDIAFLLLYFNDTHKSIRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTASSSK 282 G S F++ +F + ++ L R + +R++ R + S+ +++ Sbjct: 293 GPQSKQ-PFMVAFF-------KASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDY 344 Query: 283 HSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQN 342 ++ + C H +SFR LGW WIIAP Y YC G C L +N+ NHAI+Q Sbjct: 345 NTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQT 404 Query: 343 LINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391 L++ + VP+P C P K ISVL + + +++ K+Y M+ SC C Sbjct: 405 LVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453 >gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sapiens] Length = 408 Score = 102 bits (253), Expect = 8e-22 Identities = 60/170 (35%), Positives = 87/170 (51%), Gaps = 13/170 (7%) Query: 234 LYFNDTHKS--IRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTAS-----SSKHSGP 286 L+ TH+ +R ++ LP+G + + LL T DG +T S KH Sbjct: 241 LHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLV-TFGHDGRGHALTRRRRAKRSPKHHSQ 299 Query: 287 ----ENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQN 342 +N C H + F +GW+ WI+APP Y YC G C L D LNS NHAI+Q Sbjct: 300 RARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQT 359 Query: 343 LINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR 392 L+N V+ S+P+ CVP + IS+L ++ ++ K Y+ M+ E C CR Sbjct: 360 LVNS-VNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408 >gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sapiens] Length = 408 Score = 102 bits (253), Expect = 8e-22 Identities = 60/170 (35%), Positives = 87/170 (51%), Gaps = 13/170 (7%) Query: 234 LYFNDTHKS--IRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTAS-----SSKHSGP 286 L+ TH+ +R ++ LP+G + + LL T DG +T S KH Sbjct: 241 LHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLV-TFGHDGRGHALTRRRRAKRSPKHHSQ 299 Query: 287 ----ENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQN 342 +N C H + F +GW+ WI+APP Y YC G C L D LNS NHAI+Q Sbjct: 300 RARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQT 359 Query: 343 LINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR 392 L+N V+ S+P+ CVP + IS+L ++ ++ K Y+ M+ E C CR Sbjct: 360 LVNS-VNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408 >gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sapiens] Length = 408 Score = 102 bits (253), Expect = 8e-22 Identities = 60/170 (35%), Positives = 87/170 (51%), Gaps = 13/170 (7%) Query: 234 LYFNDTHKS--IRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTAS-----SSKHSGP 286 L+ TH+ +R ++ LP+G + + LL T DG +T S KH Sbjct: 241 LHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLV-TFGHDGRGHALTRRRRAKRSPKHHSQ 299 Query: 287 ----ENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQN 342 +N C H + F +GW+ WI+APP Y YC G C L D LNS NHAI+Q Sbjct: 300 RARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQT 359 Query: 343 LINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR 392 L+N V+ S+P+ CVP + IS+L ++ ++ K Y+ M+ E C CR Sbjct: 360 LVNS-VNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408 >gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapiens] Length = 396 Score = 102 bits (253), Expect = 8e-22 Identities = 44/104 (42%), Positives = 62/104 (59%), Gaps = 1/104 (0%) Query: 289 NQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLV 348 + C HP + F +GW+ WI+APP Y YC G C L D LNS NHAI+Q L+N V Sbjct: 294 SSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNS-V 352 Query: 349 DQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR 392 + +P+ CVP + IS+L ++ N ++ K Y+ M+ E C CR Sbjct: 353 NSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR 396 >gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens] Length = 431 Score = 99.8 bits (247), Expect = 4e-21 Identities = 50/161 (31%), Positives = 83/161 (51%), Gaps = 6/161 (3%) Query: 231 FLLLYFNDTHKSIRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTASSSKHSGPENNQ 290 F++ +F T R + G ++ + S + ++A ++ SSS + Sbjct: 276 FMVAFFKATEVHFRSIR--STGSKQRSQNRSKTPKNQEALRMANVAENSSSD----QRQA 329 Query: 291 CSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQ 350 C H +SFR LGW WIIAP Y YC+G C L +N+ NHAI+Q L++ + + Sbjct: 330 CKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPE 389 Query: 351 SVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391 +VP+P C P + ISVL + + +++ K+Y M+ +C C Sbjct: 390 TVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430 >gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sapiens] Length = 424 Score = 96.7 bits (239), Expect = 3e-20 Identities = 69/236 (29%), Positives = 106/236 (44%), Gaps = 27/236 (11%) Query: 178 SNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQQKD------SGGLELWHGTSSLDIAF 231 ++ W+ D+T +++ W G +L + + D SG LE+ + Sbjct: 195 NSEWETFDVTDAIRR--WQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSAQNKHNP- 251 Query: 232 LLLYFNDTHKSIRKAKF----------LPR----GMEEFMERESLLRRTRQADGISAEVT 277 LL+ F+D S ++ K LP G++ F + I + T Sbjct: 252 LLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDST 311 Query: 278 ASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNH 337 A +++ + N C P I F+++GWD WIIAPP Y C+G C L + L H Sbjct: 312 ARIRRNA--KGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKH 369 Query: 338 AIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYK-EYEGMIAESCTCR 392 AIIQ L++ Q + CVP K PIS+L ++ G + YK +YEGM C CR Sbjct: 370 AIIQALVHLKNSQKASKACCVPTKLEPISILYLD-KGVVTYKFKYEGMAVSECGCR 424 >gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sapiens] Length = 402 Score = 93.2 bits (230), Expect = 4e-19 Identities = 88/356 (24%), Positives = 143/356 (40%), Gaps = 31/356 (8%) Query: 53 PGEQPRKPRLLGHSLRYMLELYRRSA---DSHGHPRENRTIGATMVRLVKPLTSVAR--- 106 P P RL + +ML+LY A D G P E R A +V + R Sbjct: 60 PRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAERRLGRADLVMSFVNMVERDRALG 119 Query: 107 ---PHRGTWHIQILGFPLRPNRGLYQLVRATVVYRHHLQLTRFNLSCHVEPW--VQKNPT 161 PH + + P + R V HL N + HV + VQ+ Sbjct: 120 HQEPHWKEFRFDLTQIPAGEAVTAAEF-RIYKVPSIHL----LNRTLHVSMFQVVQEQSN 174 Query: 162 NHFPSSEGDSSKPSLMSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQQK----DSG- 216 D W +D+T W K H+ L LR + + D G Sbjct: 175 RESDLFFLDLQTLRAGDEGWLVLDVT--AASDCWLLKRHKDLGLRLYVETEDGHSVDPGL 232 Query: 217 -GLELWHGTSSLDIAFLLLYFNDTHKSIRKAKFLPRGMEEFMERESLLRRTRQADGISAE 275 GL L F++ +F + IR + + ++ + L + + GI + Sbjct: 233 AGL-LGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDD 291 Query: 276 VTASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSP 335 V H C H +SF+ LGW W+IAP Y+ YC+G C L +N+ Sbjct: 292 V------HGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNAT 345 Query: 336 NHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391 NHAI+Q+L++ ++ +VP+ C P K SVL +++ +++ +++ M+ ++C C Sbjct: 346 NHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401 >gi|145611428 bone morphogenetic protein 8A [Homo sapiens] Length = 402 Score = 92.0 bits (227), Expect = 8e-19 Identities = 88/356 (24%), Positives = 143/356 (40%), Gaps = 31/356 (8%) Query: 53 PGEQPRKPRLLGHSLRYMLELYRRSA---DSHGHPRENRTIGATMVRLVKPLTSVAR--- 106 P P RL + +ML+LY A D G P E R A +V + R Sbjct: 60 PRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAEQRLGRADLVMSFVNMVERDRALG 119 Query: 107 ---PHRGTWHIQILGFPLRPNRGLYQLVRATVVYRHHLQLTRFNLSCHVEPW--VQKNPT 161 PH + + P + R V HL N + HV + VQ+ Sbjct: 120 HQEPHWKEFRFDLTQIPAGEAVTAAEF-RIYKVPSIHL----LNRTLHVSMFQVVQEQSN 174 Query: 162 NHFPSSEGDSSKPSLMSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQQK----DSG- 216 D W +D+T W K H+ L LR + + D G Sbjct: 175 RESDLFFLDLQTLRAGDEGWLVLDVT--AASDCWLLKRHKDLGLRLYVETEDGHSVDPGL 232 Query: 217 -GLELWHGTSSLDIAFLLLYFNDTHKSIRKAKFLPRGMEEFMERESLLRRTRQADGISAE 275 GL L F++ +F + IR + + ++ + L + + GI + Sbjct: 233 AGL-LGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDD 291 Query: 276 VTASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSP 335 V S + C H +SF+ LGW W+IAP Y+ YC+G C L +N+ Sbjct: 292 VRGSHGRQV------CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNAT 345 Query: 336 NHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391 NHAI+Q+L++ + +VP+ C P K SVL +++ +++ +++ M+ ++C C Sbjct: 346 NHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401 >gi|10190670 growth differentiation factor 3 precursor [Homo sapiens] Length = 364 Score = 91.7 bits (226), Expect = 1e-18 Identities = 43/103 (41%), Positives = 60/103 (58%), Gaps = 1/103 (0%) Query: 289 NQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLV 348 N C H I+FR LGW WIIAP + NYC G C L LNS N+A +Q L++ V Sbjct: 262 NLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMH-AV 320 Query: 349 DQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391 D +P+ C+P K PIS+L + N +++ + YE M+ + C C Sbjct: 321 DPEIPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGC 363 >gi|7705308 growth differentiation factor 2 [Homo sapiens] Length = 429 Score = 90.9 bits (224), Expect = 2e-18 Identities = 84/352 (23%), Positives = 145/352 (41%), Gaps = 36/352 (10%) Query: 68 RYMLELYRR-SADSHGHPRENRTIGATMVRLVKPLTSVARPHRGTWHIQILGFPL----- 121 +YM++LY R ++D P N +M + + P + HI + + Sbjct: 87 QYMIDLYNRYTSDKSTTPASNIVRSFSMEDAISITATEDFPFQK--HILLFNISIPRHEQ 144 Query: 122 --RPNRGLYQLVRATVVYRHHLQ--LTRFNLSCHVEPWVQKNPTNHFPSSEGDSSKPSLM 177 R LY + V H L+ + +++ + W T F S+ + Sbjct: 145 ITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQ------DIQ 198 Query: 178 SNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQ-QKDSGGLELWHGTSSLDIAFLLLYF 236 W+ ++++ V++ ++ +L + +K L++ S ++ F +++ Sbjct: 199 DEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTLDISVPPGSRNLPFFVVFS 258 Query: 237 NDTHKSIRKAKFLPRGMEEFMERESLLRRTRQ--------------ADG-ISAEVTASSS 281 ND ++ + R M E+ES+L++ + DG ++A T + Sbjct: 259 NDHSSGTKETRLELREMISH-EQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARR 317 Query: 282 KHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQ 341 K S + C +++F +GWD WIIAP Y CKG C L D + HAI+Q Sbjct: 318 KRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQ 377 Query: 342 NLINQLVDQSVPRPSCVPYKYVPISVLMIEANG-SILYKEYEGMIAESCTCR 392 L++ V + CVP K PISVL + G L YEGM C CR Sbjct: 378 TLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR 429 >gi|110349792 growth differentiation factor 1 [Homo sapiens] Length = 372 Score = 85.5 bits (210), Expect = 8e-17 Identities = 39/112 (34%), Positives = 61/112 (54%), Gaps = 4/112 (3%) Query: 285 GPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTC-LRVLRDGLNSP---NHAII 340 G C +SFR++GW W+IAP + NYC+G C L V G P NHA++ Sbjct: 261 GGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVL 320 Query: 341 QNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR 392 + L++ + P CVP + PISVL + + +++ ++YE M+ + C CR Sbjct: 321 RALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR 372 >gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sapiens] Length = 472 Score = 84.0 bits (206), Expect = 2e-16 Identities = 37/107 (34%), Positives = 55/107 (51%), Gaps = 1/107 (0%) Query: 287 ENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQ 346 E C+ ++ F +GW WII+P + YC G C + L NHA IQ+++ Sbjct: 366 EPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRA 425 Query: 347 L-VDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR 392 + V +P P CVP K +S+L + N +++ K Y M ESC CR Sbjct: 426 VGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR 472 >gi|222352098 nodal precursor [Homo sapiens] Length = 347 Score = 79.7 bits (195), Expect = 4e-15 Identities = 39/111 (35%), Positives = 58/111 (52%), Gaps = 2/111 (1%) Query: 282 KHSGPENNQ-CSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAII 340 +H P+ +Q C FQ+ F +GW WII P Y C+G C + + + NHA I Sbjct: 237 RHHLPDRSQLCRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYI 296 Query: 341 QNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391 Q+L+ + VP C P K P+S+L ++ NG +L ++ MI E C C Sbjct: 297 QSLLKRYQPHRVPSTCCAPVKTKPLSMLYVD-NGRVLLDHHKDMIVEECGC 346 >gi|4826740 growth differentiation factor 10 precursor [Homo sapiens] Length = 478 Score = 77.8 bits (190), Expect = 2e-14 Identities = 39/143 (27%), Positives = 66/143 (46%), Gaps = 8/143 (5%) Query: 251 RGMEEFMERESLLRRTRQADGISAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWII 310 +G E FM +L + + + E CS ++ F +GW+ WII Sbjct: 343 KGQEVFMAASQVL-------DFDEKTMQKARRKQWDEPRVCSRRYLKVDFADIGWNEWII 395 Query: 311 APPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQL-VDQSVPRPSCVPYKYVPISVLM 369 +P + YC G C + + NHA IQ+++ + + +P P CVP K + VL Sbjct: 396 SPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLF 455 Query: 370 IEANGSILYKEYEGMIAESCTCR 392 ++ N +++ K Y M ++C CR Sbjct: 456 LDENRNVVLKVYPNMSVDTCACR 478 >gi|5031613 growth differentiation factor 11 precursor [Homo sapiens] Length = 407 Score = 69.3 bits (168), Expect = 6e-12 Identities = 46/147 (31%), Positives = 66/147 (44%), Gaps = 27/147 (18%) Query: 252 GMEEFMERESL--LRRTRQADGISAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWI 309 G+ FME L +R+R+ G+ + +S S+ C +P + F GWD WI Sbjct: 280 GLHPFMELRVLENTKRSRRNLGLDCDEHSSESR--------CCRYPLTVDFEAFGWD-WI 330 Query: 310 IAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLIN-QLVDQSVPR----PSCVPYKYVP 364 IAP Y NYC G C + +Q + LV Q+ PR P C P K P Sbjct: 331 IAPKRYKANYCSGQC-----------EYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSP 379 Query: 365 ISVLMIEANGSILYKEYEGMIAESCTC 391 I++L I+Y + GM+ + C C Sbjct: 380 INMLYFNDKQQIIYGKIPGMVVDRCGC 406 >gi|4885259 myostatin [Homo sapiens] Length = 375 Score = 65.5 bits (158), Expect = 8e-11 Identities = 41/142 (28%), Positives = 64/142 (45%), Gaps = 17/142 (11%) Query: 252 GMEEFMERE--SLLRRTRQADGISAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWI 309 G+ F+E + +R+R+ G+ + ++ S+ C +P + F GWD WI Sbjct: 248 GLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESR--------CCRYPLTVDFEAFGWD-WI 298 Query: 310 IAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLM 369 IAP Y NYC G C V L H +L++Q + P C P K PI++L Sbjct: 299 IAPKRYKANYCSGECEFVF---LQKYPHT---HLVHQANPRGSAGPCCTPTKMSPINMLY 352 Query: 370 IEANGSILYKEYEGMIAESCTC 391 I+Y + M+ + C C Sbjct: 353 FNGKEQIIYGKIPAMVVDRCGC 374 >gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens] Length = 407 Score = 65.5 bits (158), Expect = 8e-11 Identities = 51/219 (23%), Positives = 89/219 (40%), Gaps = 36/219 (16%) Query: 176 LMSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQQKDSGGLELWHGTSSLDIAFLLLY 235 L + W +T+ +Q F +G R L L C S ++A + ++ Sbjct: 221 LKRSGWHTFPLTEAIQALF--ERGERRLNLDVQCD--------------SCQELAVVPVF 264 Query: 236 FNDTHKSIRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTASSSKHSGPENNQCSLHP 295 + +S R + + + R + +R + DG N C Sbjct: 265 VDPGEESHRPFVVVQARLGD--SRHRIRKRGLECDG---------------RTNLCCRQQ 307 Query: 296 FQISFRQLGWDHWIIAPPFYTPNYCKGTC---LRVLRDGLNSPNHAIIQNLINQLVDQSV 352 F I FR +GW+ WIIAP Y NYC+G+C L + +S + A++ + ++ Sbjct: 308 FFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGLNPGT 367 Query: 353 PRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391 C+P K +S+L + +I+ ++ MI E C C Sbjct: 368 VNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGC 406 >gi|4504699 inhibin beta A precursor [Homo sapiens] Length = 426 Score = 63.9 bits (154), Expect = 2e-10 Identities = 35/108 (32%), Positives = 54/108 (50%), Gaps = 6/108 (5%) Query: 289 NQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLV 348 N C F +SF+ +GW+ WIIAP Y NYC+G C + G + + + +IN Sbjct: 319 NICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIA-GTSGSSLSFHSTVINHYR 377 Query: 349 DQSVP-----RPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391 + + CVP K P+S+L + +I+ K+ + MI E C C Sbjct: 378 MRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 425 >gi|13899338 activin beta E [Homo sapiens] Length = 350 Score = 62.8 bits (151), Expect = 5e-10 Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 2/108 (1%) Query: 286 PENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVL--RDGLNSPNHAIIQNL 343 P C + F++LGW WI+ P Y NYC G C L G+ + H+ + +L Sbjct: 242 PATPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSL 301 Query: 344 INQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391 + CVP P+S+L ++ NG+++ + M+ E+C C Sbjct: 302 LKANNPWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGC 349 >gi|153792495 growth differentiation factor 15 [Homo sapiens] Length = 308 Score = 60.8 bits (146), Expect = 2e-09 Identities = 31/101 (30%), Positives = 51/101 (50%), Gaps = 4/101 (3%) Query: 291 CSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQ 350 C LH + S LGW W+++P C G C R + HA I+ +++L Sbjct: 211 CRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFR---AANMHAQIKTSLHRLKPD 267 Query: 351 SVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391 +VP P CVP Y P+ VL+ + + + + Y+ ++A+ C C Sbjct: 268 TVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDCHC 307 >gi|239757187 PREDICTED: similar to growth differentiation factor 15 [Homo sapiens] Length = 270 Score = 60.8 bits (146), Expect = 2e-09 Identities = 31/101 (30%), Positives = 51/101 (50%), Gaps = 4/101 (3%) Query: 291 CSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQ 350 C LH + S LGW W+++P C G C R + HA I+ +++L Sbjct: 173 CRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFR---AANMHAQIKTSLHRLKPD 229 Query: 351 SVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391 +VP P CVP Y P+ VL+ + + + + Y+ ++A+ C C Sbjct: 230 TVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDCHC 269 >gi|5031795 inhibin beta C chain preproprotein [Homo sapiens] Length = 352 Score = 59.7 bits (143), Expect = 4e-09 Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 4/108 (3%) Query: 288 NNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTC-LRVL-RDGLNSPNHAIIQNLI- 344 + C F + FR++GW WII P Y N+C G C L + G+ + H + NL+ Sbjct: 244 SRMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLK 303 Query: 345 -NQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391 N + CVP P+S+L + + +I+ + M+ E+C C Sbjct: 304 ANTAAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGC 351 >gi|4507465 transforming growth factor, beta 3 [Homo sapiens] Length = 412 Score = 52.8 bits (125), Expect = 5e-07 Identities = 32/102 (31%), Positives = 47/102 (46%), Gaps = 6/102 (5%) Query: 291 CSLHPFQISFRQ-LGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVD 349 C + P I FRQ LGW W+ P Y N+C G C LR H+ + L N L Sbjct: 315 CCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPC-PYLRSA--DTTHSTVLGLYNTLNP 370 Query: 350 QSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391 ++ P CVP P+++L + ++ M+ +SC C Sbjct: 371 EASASPCCVPQDLEPLTILYY-VGRTPKVEQLSNMVVKSCKC 411 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.322 0.136 0.425 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,650,772 Number of Sequences: 37866 Number of extensions: 697664 Number of successful extensions: 1798 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 37 Number of HSP's successfully gapped in prelim test: 12 Number of HSP's that attempted gapping in prelim test: 1734 Number of HSP's gapped (non-prelim): 55 length of query: 392 length of database: 18,247,518 effective HSP length: 104 effective length of query: 288 effective length of database: 14,309,454 effective search space: 4121122752 effective search space used: 4121122752 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.