Guide to the Human Genome
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Search of human proteins with 48675813

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|48675813 transportin 2 (importin 3, karyopherin beta 2b)
isoform 2 [Homo sapiens]
         (887 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|209969836 transportin 2 (importin 3, karyopherin beta 2b) iso...  1800   0.0  
gi|48675813 transportin 2 (importin 3, karyopherin beta 2b) isof...  1800   0.0  
gi|209969838 transportin 2 (importin 3, karyopherin beta 2b) iso...  1792   0.0  
gi|23510381 transportin 1 isoform 2 [Homo sapiens]                   1566   0.0  
gi|133925811 transportin 1 isoform 1 [Homo sapiens]                  1566   0.0  
gi|19923142 karyopherin beta 1 [Homo sapiens]                         120   6e-27
gi|24797086 importin 5 [Homo sapiens]                                  67   6e-11
gi|62460637 importin 4 [Homo sapiens]                                  66   1e-10
gi|45331213 RAN binding protein 6 [Homo sapiens]                       65   2e-10
gi|198041777 Ran binding protein 11 isoform 1 [Homo sapiens]           47   6e-05
gi|39725950 Ran binding protein 11 isoform 2 [Homo sapiens]            47   6e-05
gi|21361659 importin 9 [Homo sapiens]                                  47   6e-05
gi|29029559 CSE1 chromosome segregation 1-like protein [Homo sap...    43   0.001
gi|122937211 KIAA0368 protein [Homo sapiens]                           39   0.021
gi|4507943 exportin 1 [Homo sapiens]                                   38   0.048
gi|4504901 karyopherin alpha 4 [Homo sapiens]                          38   0.048
gi|55956788 nucleolin [Homo sapiens]                                   37   0.062
gi|6912478 karyopherin alpha 6 [Homo sapiens]                          37   0.081
gi|4507397 transcription factor 2 [Homo sapiens]                       36   0.14 
gi|54607053 GCN1 general control of amino-acid synthesis 1-like ...    36   0.14 
gi|21361794 TIP120 protein [Homo sapiens]                              36   0.18 
gi|32455246 beta isoform of regulatory subunit A, protein phosph...    35   0.24 
gi|32455244 beta isoform of regulatory subunit A, protein phosph...    35   0.24 
gi|27477070 BTAF1 RNA polymerase II, B-TFIID transcription facto...    35   0.24 
gi|154350213 hypothetical protein LOC79591 [Homo sapiens]              35   0.40 
gi|241982712 TBP-interacting protein isoform 1 [Homo sapiens]          34   0.69 
gi|112420977 TBP-interacting protein isoform 2 [Homo sapiens]          34   0.69 
gi|89886480 zinedin isoform 2 [Homo sapiens]                           34   0.69 
gi|89886477 zinedin isoform 1 [Homo sapiens]                           34   0.69 
gi|54112117 splicing factor 3b, subunit 1 isoform 1 [Homo sapiens]     34   0.69 

>gi|209969836 transportin 2 (importin 3, karyopherin beta 2b)
           isoform 3 [Homo sapiens]
          Length = 887

 Score = 1800 bits (4662), Expect = 0.0
 Identities = 887/887 (100%), Positives = 887/887 (100%)

Query: 1   MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDE 60
           MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDE
Sbjct: 1   MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDE 60

Query: 61  PTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGE 120
           PTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGE
Sbjct: 61  PTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGE 120

Query: 121 LQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQF 180
           LQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQF
Sbjct: 121 LQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQF 180

Query: 181 FKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVML 240
           FKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVML
Sbjct: 181 FKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVML 240

Query: 241 LEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIP 300
           LEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIP
Sbjct: 241 LEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIP 300

Query: 301 ILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAED 360
           ILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAED
Sbjct: 301 ILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAED 360

Query: 361 DDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGA 420
           DDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGA
Sbjct: 361 DDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGA 420

Query: 421 IAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMT 480
           IAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMT
Sbjct: 421 IAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMT 480

Query: 481 ELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYD 540
           ELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYD
Sbjct: 481 ELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYD 540

Query: 541 AIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLP 600
           AIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLP
Sbjct: 541 AIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLP 600

Query: 601 YCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLV 660
           YCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLV
Sbjct: 601 YCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLV 660

Query: 661 ARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFIS 720
           ARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFIS
Sbjct: 661 ARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFIS 720

Query: 721 VCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTAITIGRLGYVCP 780
           VCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTAITIGRLGYVCP
Sbjct: 721 VCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTAITIGRLGYVCP 780

Query: 781 QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFIFFCDAVASWV 840
           QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFIFFCDAVASWV
Sbjct: 781 QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFIFFCDAVASWV 840

Query: 841 SPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV 887
           SPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV
Sbjct: 841 SPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV 887


>gi|48675813 transportin 2 (importin 3, karyopherin beta 2b) isoform
           2 [Homo sapiens]
          Length = 887

 Score = 1800 bits (4662), Expect = 0.0
 Identities = 887/887 (100%), Positives = 887/887 (100%)

Query: 1   MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDE 60
           MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDE
Sbjct: 1   MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDE 60

Query: 61  PTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGE 120
           PTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGE
Sbjct: 61  PTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGE 120

Query: 121 LQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQF 180
           LQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQF
Sbjct: 121 LQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQF 180

Query: 181 FKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVML 240
           FKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVML
Sbjct: 181 FKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVML 240

Query: 241 LEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIP 300
           LEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIP
Sbjct: 241 LEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIP 300

Query: 301 ILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAED 360
           ILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAED
Sbjct: 301 ILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAED 360

Query: 361 DDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGA 420
           DDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGA
Sbjct: 361 DDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGA 420

Query: 421 IAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMT 480
           IAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMT
Sbjct: 421 IAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMT 480

Query: 481 ELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYD 540
           ELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYD
Sbjct: 481 ELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYD 540

Query: 541 AIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLP 600
           AIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLP
Sbjct: 541 AIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLP 600

Query: 601 YCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLV 660
           YCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLV
Sbjct: 601 YCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLV 660

Query: 661 ARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFIS 720
           ARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFIS
Sbjct: 661 ARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFIS 720

Query: 721 VCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTAITIGRLGYVCP 780
           VCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTAITIGRLGYVCP
Sbjct: 721 VCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTAITIGRLGYVCP 780

Query: 781 QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFIFFCDAVASWV 840
           QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFIFFCDAVASWV
Sbjct: 781 QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFIFFCDAVASWV 840

Query: 841 SPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV 887
           SPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV
Sbjct: 841 SPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV 887


>gi|209969838 transportin 2 (importin 3, karyopherin beta 2b)
           isoform 1 [Homo sapiens]
          Length = 897

 Score = 1792 bits (4641), Expect = 0.0
 Identities = 887/897 (98%), Positives = 887/897 (98%), Gaps = 10/897 (1%)

Query: 1   MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDE 60
           MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDE
Sbjct: 1   MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDE 60

Query: 61  PTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGE 120
           PTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGE
Sbjct: 61  PTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGE 120

Query: 121 LQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQF 180
           LQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQF
Sbjct: 121 LQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQF 180

Query: 181 FKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVML 240
           FKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVML
Sbjct: 181 FKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVML 240

Query: 241 LEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIP 300
           LEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIP
Sbjct: 241 LEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIP 300

Query: 301 ILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAED 360
           ILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAED
Sbjct: 301 ILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAED 360

Query: 361 DDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGA 420
           DDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGA
Sbjct: 361 DDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGA 420

Query: 421 IAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMT 480
           IAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMT
Sbjct: 421 IAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMT 480

Query: 481 ELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYD 540
           ELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYD
Sbjct: 481 ELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYD 540

Query: 541 AIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLP 600
           AIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLP
Sbjct: 541 AIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLP 600

Query: 601 YCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLV 660
           YCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLV
Sbjct: 601 YCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLV 660

Query: 661 ARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFIS 720
           ARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFIS
Sbjct: 661 ARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFIS 720

Query: 721 VCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENT----------AI 770
           VCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENT          AI
Sbjct: 721 VCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTGRLTSPSAIPAI 780

Query: 771 TIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFI 830
           TIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFI
Sbjct: 781 TIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFI 840

Query: 831 FFCDAVASWVSPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV 887
           FFCDAVASWVSPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV
Sbjct: 841 FFCDAVASWVSPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV 897


>gi|23510381 transportin 1 isoform 2 [Homo sapiens]
          Length = 890

 Score = 1566 bits (4055), Expect = 0.0
 Identities = 758/887 (85%), Positives = 830/887 (93%), Gaps = 1/887 (0%)

Query: 2   DWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEP 61
           +W+PDEQGLQQ+LQLLK+SQSP+T  QR VQ KL+QLNQ+PDFNNYLIFVLT+LKSEDEP
Sbjct: 4   EWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEP 63

Query: 62  TRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGEL 121
           TRSLSGLILKNNVKAH+Q+FP  V DFIK ECLNNIGD+S LIRAT+GILITTIASKGEL
Sbjct: 64  TRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGEL 123

Query: 122 QMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFF 181
           Q WP+LLP+LC+LL+SEDYNTCEGAFGALQKICEDS+E+LDSD L+RPLNIMIPKFLQFF
Sbjct: 124 QNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQFF 183

Query: 182 KHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLL 241
           KH SPKIRSHA+ACVNQFI+ R QALM +ID+FIE+LFALA D++PEVRKNVCRALVMLL
Sbjct: 184 KHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLL 243

Query: 242 EVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPI 301
           EVR+DRL+PHMH+I++YMLQRTQD DENVALEACEFWLTLAEQPICK+VL  HL +LIP+
Sbjct: 244 EVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPV 303

Query: 302 LVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAEDD 361
           LVNGMKYS+IDIILLKGDVEEDE +PDSEQDI+PRFH+SRTV   H+ +  +  +D +D+
Sbjct: 304 LVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDE 363

Query: 362 -DDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGA 420
            DDDD +SDWNLRKCSAAALDVLANV+R+ELLPH+LPLLK LLFH EWVVKESGILVLGA
Sbjct: 364 IDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGA 423

Query: 421 IAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMT 480
           IAEGCMQGM+PYLPELIPHLIQCLSDKKALVRSI CWTLSRYAHWVVSQPPD +LKPLMT
Sbjct: 424 IAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMT 483

Query: 481 ELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYD 540
           ELLKRILD NKRVQEAACSAFATLEEEACTELVPYL+YILDTLVFAF KYQHKNLLILYD
Sbjct: 484 ELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYD 543

Query: 541 AIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLP 600
           AIGTLADSVGHHLN+PEYIQ LMPPLIQKWN LKDEDKDLFPLLECLSSVATALQSGFLP
Sbjct: 544 AIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLP 603

Query: 601 YCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLV 660
           YCEPVYQRCV LVQKTLAQAM+    P+QYEAPDKDFMIVALDLLSGLAEGLGG++EQLV
Sbjct: 604 YCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLV 663

Query: 661 ARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFIS 720
           ARSNI+TL++QCMQD MPEVRQSSFALLGDLTKACF HVKPCIA+FMPILGTNLNPEFIS
Sbjct: 664 ARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFIS 723

Query: 721 VCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTAITIGRLGYVCP 780
           VCNNATWAIGEI +QMG EMQPY+ MVL+ LVEIINRPNTPKTLLENTAITIGRLGYVCP
Sbjct: 724 VCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCP 783

Query: 781 QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFIFFCDAVASWV 840
           QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGIC MI VNP GV+QDFIFFCDAVASW+
Sbjct: 784 QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWI 843

Query: 841 SPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV 887
           +PKDDLRDMF KILHGFK+QVG++NW++FS+QFP  LKERLAAFYGV
Sbjct: 844 NPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV 890


>gi|133925811 transportin 1 isoform 1 [Homo sapiens]
          Length = 898

 Score = 1566 bits (4055), Expect = 0.0
 Identities = 758/887 (85%), Positives = 830/887 (93%), Gaps = 1/887 (0%)

Query: 2   DWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEP 61
           +W+PDEQGLQQ+LQLLK+SQSP+T  QR VQ KL+QLNQ+PDFNNYLIFVLT+LKSEDEP
Sbjct: 12  EWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEP 71

Query: 62  TRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGEL 121
           TRSLSGLILKNNVKAH+Q+FP  V DFIK ECLNNIGD+S LIRAT+GILITTIASKGEL
Sbjct: 72  TRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGEL 131

Query: 122 QMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFF 181
           Q WP+LLP+LC+LL+SEDYNTCEGAFGALQKICEDS+E+LDSD L+RPLNIMIPKFLQFF
Sbjct: 132 QNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQFF 191

Query: 182 KHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLL 241
           KH SPKIRSHA+ACVNQFI+ R QALM +ID+FIE+LFALA D++PEVRKNVCRALVMLL
Sbjct: 192 KHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLL 251

Query: 242 EVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPI 301
           EVR+DRL+PHMH+I++YMLQRTQD DENVALEACEFWLTLAEQPICK+VL  HL +LIP+
Sbjct: 252 EVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPV 311

Query: 302 LVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAEDD 361
           LVNGMKYS+IDIILLKGDVEEDE +PDSEQDI+PRFH+SRTV   H+ +  +  +D +D+
Sbjct: 312 LVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDE 371

Query: 362 -DDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGA 420
            DDDD +SDWNLRKCSAAALDVLANV+R+ELLPH+LPLLK LLFH EWVVKESGILVLGA
Sbjct: 372 IDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGA 431

Query: 421 IAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMT 480
           IAEGCMQGM+PYLPELIPHLIQCLSDKKALVRSI CWTLSRYAHWVVSQPPD +LKPLMT
Sbjct: 432 IAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMT 491

Query: 481 ELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYD 540
           ELLKRILD NKRVQEAACSAFATLEEEACTELVPYL+YILDTLVFAF KYQHKNLLILYD
Sbjct: 492 ELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYD 551

Query: 541 AIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLP 600
           AIGTLADSVGHHLN+PEYIQ LMPPLIQKWN LKDEDKDLFPLLECLSSVATALQSGFLP
Sbjct: 552 AIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLP 611

Query: 601 YCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLV 660
           YCEPVYQRCV LVQKTLAQAM+    P+QYEAPDKDFMIVALDLLSGLAEGLGG++EQLV
Sbjct: 612 YCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLV 671

Query: 661 ARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFIS 720
           ARSNI+TL++QCMQD MPEVRQSSFALLGDLTKACF HVKPCIA+FMPILGTNLNPEFIS
Sbjct: 672 ARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFIS 731

Query: 721 VCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTAITIGRLGYVCP 780
           VCNNATWAIGEI +QMG EMQPY+ MVL+ LVEIINRPNTPKTLLENTAITIGRLGYVCP
Sbjct: 732 VCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCP 791

Query: 781 QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFIFFCDAVASWV 840
           QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGIC MI VNP GV+QDFIFFCDAVASW+
Sbjct: 792 QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWI 851

Query: 841 SPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV 887
           +PKDDLRDMF KILHGFK+QVG++NW++FS+QFP  LKERLAAFYGV
Sbjct: 852 NPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV 898


>gi|19923142 karyopherin beta 1 [Homo sapiens]
          Length = 876

 Score =  120 bits (301), Expect = 6e-27
 Identities = 172/794 (21%), Positives = 314/794 (39%), Gaps = 110/794 (13%)

Query: 12  QVLQLLKDSQSPNTATQRIVQDKLKQ--LNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLI 69
           +++ +L+ + SP+       Q  L++  +   P F   L  VL       +  R  +GL 
Sbjct: 2   ELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLAN-PGNSQVARVAAGLQ 60

Query: 70  LKNN-------VKAHYQ----SFPPPVADFIKQECLNNIGDA----SSLIRATIGILITT 114
           +KN+       +KA YQ    +        +K   L  +G      SS  +   GI    
Sbjct: 61  IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE 120

Query: 115 IASKGELQMWPELLPQL-CNLLN-SEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNI 172
           I     +  WPEL+PQL  N+ N +   +  E    A+  IC+D    +D + L    N 
Sbjct: 121 IP----VNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQD----IDPEQLQDKSNE 172

Query: 173 MIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVD------DD 226
           ++   +Q  +   P   +  +A  N  +++  +    N D   E  F + V        D
Sbjct: 173 ILTAIIQGMRKEEPS-NNVKLAATNA-LLNSLEFTKANFDKESERHFIMQVVCEATQCPD 230

Query: 227 PEVRKNVCRALVMLLEVRIDRLIPHMH-SIIQYMLQRTQDHDENVALEACEFWLTLAEQP 285
             VR    + LV ++ +    +  +M  ++    ++  +   + VAL+  EFW  + ++ 
Sbjct: 231 TRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDE- 289

Query: 286 ICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTL 345
                                   E+D+ +   +  E    P+        + K     L
Sbjct: 290 ------------------------EMDLAIEASEAAEQGRPPEHTSKF---YAKGALQYL 322

Query: 346 PHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFH 405
                +    +D  DDDDD     WN  K +   L +LA    ++++PH+LP +K  + +
Sbjct: 323 VPILTQTLTKQDENDDDDD-----WNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKN 377

Query: 406 PEWVVKESGILVLGAIAEGCMQGMV-PYLPELIPHLIQCLSDKKALVRSIACWTLSRYAH 464
           P+W  +++ ++  G I EG     + P + + +P LI+ + D   +VR  A WT+ R   
Sbjct: 378 PDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICE 437

Query: 465 WVVSQP-PDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTL 523
            +      D++L PL+  L++  L    RV    C AF++L  EA  E         +  
Sbjct: 438 LLPEAAINDVYLAPLLQCLIEG-LSAEPRVASNVCWAFSSL-AEAAYEAADVADDQEEPA 495

Query: 524 VFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPL 583
            +          LI+   + T     GH  N      + +  ++      K+  KD +P 
Sbjct: 496 TYCLSSSFE---LIVQKLLETTDRPDGHQNNLRSSAYESLMEIV------KNSAKDCYPA 546

Query: 584 LECLSSV-------ATALQSGFLPYCEPV-YQRCVTLVQKTLAQAMMYTQHPEQYEAPDK 635
           ++  + V          ++S      + + +    +L+  TL   +   QH +  +  D 
Sbjct: 547 VQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDV 606

Query: 636 DFMIVALDLLSGLAEGLGGHVEQLVARSNIMTLL----FQCMQDSMP------------E 679
             M   L +    A   G   + L+A S ++ +L     + M+   P            +
Sbjct: 607 -VMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQ 665

Query: 680 VRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFI--SVCNNATWAIGEICMQMG 737
           V  ++  L+GDL +A   ++ P   E M +L  NL  E +  SV        G+I + +G
Sbjct: 666 VCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIALAIG 725

Query: 738 AEMQPYVQMVLNNL 751
            E + Y+++VLN L
Sbjct: 726 GEFKKYLEVVLNTL 739


>gi|24797086 importin 5 [Homo sapiens]
          Length = 1115

 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 132/616 (21%), Positives = 243/616 (39%), Gaps = 88/616 (14%)

Query: 11  QQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSED--EPTRSLSGL 68
           QQ   LL +  SP+   ++  ++  + +       + + F+L  +++    E  R ++ +
Sbjct: 27  QQFYLLLGNLLSPDNVVRKQAEETYENIPG----QSKITFLLQAIRNTTAAEEARQMAAV 82

Query: 69  ILKNNVKAH----YQSFPPPVADFIKQECLNNIG--DASSLIRATIGI---LITTIASKG 119
           +L+  + +     Y + P  V   IK E L  I     SS+ +    I   L   +  + 
Sbjct: 83  LLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKVCDIAAELARNLIDED 142

Query: 120 ELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKI--CEDSSELLDSDALNRPLNIMIPKF 177
               WPE L  L + ++S++    E A            + +    D + R    M+ + 
Sbjct: 143 GNNQWPEGLKFLFDSVSSQNVGLREAALHIFWNFPGIFGNQQQHYLDVIKR----MLVQC 198

Query: 178 LQFFKHCSPKIRSHAIACVNQFIM--DRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCR 235
           +Q  +H  P IR+ +      FI+  +   AL  +    +        D   +   +V +
Sbjct: 199 MQDQEH--PSIRTLSARATAAFILANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVLK 256

Query: 236 ALVMLLEVRIDRLIPHMHSIIQYMLQRTQDHDENVALE--ACEFWLTLAEQPICKEVLAS 293
           +LV + +     L PH+ + +Q  L+   D   N      A E  +TL+E      +L  
Sbjct: 257 SLVEIADTVPKYLRPHLEATLQLSLKLCGDTSLNNMQRQLALEVIVTLSETAAA--MLRK 314

Query: 294 H---LVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAE 350
           H   + Q IP            ++ +  D+EEDE                         +
Sbjct: 315 HTNIVAQTIP-----------QMLAMMVDLEEDE-------------------------D 338

Query: 351 RPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREEL-LPHLLPLLKGLLFHPEWV 409
             +  E  +DD D +A++         +ALD +A     +L LP +   +  +L +P+W 
Sbjct: 339 WANADELEDDDFDSNAVA-------GESALDRMACGLGGKLVLPMIKEHIMQMLQNPDWK 391

Query: 410 VKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQ 469
            + +G++ L AI EGC Q M   L E++  ++  L D    VR  AC  + + A      
Sbjct: 392 YRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPG 451

Query: 470 PPDMHLKPLMTELLKRILD-GNKRVQEAACSAFATLEEEACTE--LVPYL----SYILDT 522
                 + ++  LL+ + D GN+RVQ  A +A     E+ C +  L+PYL     ++   
Sbjct: 452 FQKKFHEKVIAALLQTMEDQGNQRVQAHAAAALINFTED-CPKSLLIPYLDNLVKHLHSI 510

Query: 523 LVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQP--EYIQKLMPPLIQKWNELKDEDKDL 580
           +V    +   K   ++ + + T   SV     +    Y    MP L         ++  L
Sbjct: 511 MVLKLQELIQKGTKLVLEQVVTSIASVADTAEEKFVPYYDLFMPSLKHIVENAVQKELRL 570

Query: 581 F--PLLECLSSVATAL 594
                +EC+S +  A+
Sbjct: 571 LRGKTIECISLIGLAV 586


>gi|62460637 importin 4 [Homo sapiens]
          Length = 1081

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 102/438 (23%), Positives = 185/438 (42%), Gaps = 55/438 (12%)

Query: 349 AERPDGSEDAEDDDDDDALSDWNL-----RKCSAAALDVLA-NVFREELLPHLLPLLKGL 402
           AE P G  D ED D ++   +  L     +  +   +D+LA ++  E+L P L+P+L+  
Sbjct: 301 AEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEA 360

Query: 403 LFHPEWVVKESGILVLGAIAEGCMQGMVP-YLPELIPHLIQCLSDKKALVRSIACWTLSR 461
           L       +++G+LVL  +++G    +    LP L+  + + L D   +VR+ A + L +
Sbjct: 361 LRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQ 420

Query: 462 YAHWVVSQPP----DMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLS 517
           ++  +  QP        + PL+   LK +  G+      AC A     E    ++ PYL 
Sbjct: 421 FSENL--QPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLP 478

Query: 518 YILDTLVFAF---GKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNE-L 573
            +++ ++         + K L +   A+G +A +    L          P +++   E L
Sbjct: 479 ELMECMLQLLRNPSSPRAKELAV--SALGAIATAAQASL------LPYFPAIMEHLREFL 530

Query: 574 KDEDKDLFPL----LECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQ 629
               +DL P+    LE L  +A A+     P  E   Q  + L               +Q
Sbjct: 531 LTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLC--------------DQ 576

Query: 630 YEAPDKDFMIVAL-DLLSGL-AEGLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFAL 687
            + PD      +L   LSGL  EGL  H+EQ+   + +M L  +  +  +P+   SS  L
Sbjct: 577 VDDPDLRRCTYSLFAALSGLMGEGLAPHLEQI---TTLMLLSLRSTEGIVPQYDGSSSFL 633

Query: 688 LGDLTKACFIHVKPCIAEFMP------ILGTNLNPEFISVCNNATWAIGEICMQMGAEMQ 741
           L D  ++     +  + E +       I G ++   F     +   A+GEI +       
Sbjct: 634 LFD-DESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDTCAAVGEISVNTSVAFL 692

Query: 742 PYVQMVLNNLVEIINRPN 759
           PY++ V   + +++  P+
Sbjct: 693 PYMESVFEEVFKLLECPH 710



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 90/443 (20%), Positives = 186/443 (41%), Gaps = 48/443 (10%)

Query: 376 SAAALDVLANVFREELL---PHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPY 432
           S +   + A +FR+E L   P LL LL+     P    +E G+L+L  +     +   P+
Sbjct: 97  SLSLAQLSATIFRKEGLEAWPQLLQLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPH 156

Query: 433 LPELIPHLIQCLSDKKA---LVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDG 489
             EL+  L + L +  +   L  S+   TL+  A ++ ++  D+ L  ++   L   +  
Sbjct: 157 HRELLRLLNETLGEVGSPGLLFYSLR--TLTTMAPYLSTE--DVPLARMLVPKLIMAMQT 212

Query: 490 NKRVQEA-ACSAFATLEEEACTE---LVPYLSYILDTLV-----FAFGK-YQHKNLLILY 539
              + EA AC A   L+E   +E   + PYLS +L   +      A G   + + L  L 
Sbjct: 213 LIPIDEAKACEALEALDELLESEVPVITPYLSEVLTFCLEVARNVALGNAIRIRILCCLT 272

Query: 540 DAIGTLADSVGHHLNQPEYIQKLMP---------PLIQKWNELKDEDKDLFPLLECLSSV 590
             +   + ++  +   P  +  L P          L  +  + ++E+ ++  + E     
Sbjct: 273 FLVKVKSKALLKNRLLPPLLHTLFPIVAAEPPPGQLDPEDQDSEEEELEIELMGETPKHF 332

Query: 591 ATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAE 650
           A  +      +  P         +K   Q M   +   + E+P +      L +L+ L++
Sbjct: 333 AVQVVDMLALHLPP---------EKLCPQLMPMLEEALRSESPYQ--RKAGLLVLAVLSD 381

Query: 651 GLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPIL 710
           G G H+ Q +    ++ ++ + ++D    VR ++   LG  ++    H+     E MP+L
Sbjct: 382 GAGDHIRQRLL-PPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSREVMPLL 440

Query: 711 GTNLNPEFISVCNN---ATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLEN 767
              L    +   ++   A +A+      +G ++QPY+  ++  +++++  P++P+     
Sbjct: 441 LAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRA---- 496

Query: 768 TAITIGRLGYVCPQEVAPMLQQF 790
             + +  LG +     A +L  F
Sbjct: 497 KELAVSALGAIATAAQASLLPYF 519


>gi|45331213 RAN binding protein 6 [Homo sapiens]
          Length = 1105

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 76/281 (27%), Positives = 124/281 (44%), Gaps = 49/281 (17%)

Query: 343 VTLPHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLA-NVFREELLPHLLPLLKG 401
           V L  + +  +  E  EDD D +A++       + +ALD LA  +  + +LP     +  
Sbjct: 321 VDLQDDEDWVNADEMEEDDFDSNAVA-------AESALDRLACGLGGKVVLPMTKEHIMQ 373

Query: 402 LLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSR 461
           +L  P+W  + +G++ L AI EGC Q M   L E +  ++  L D    VR+ AC TL +
Sbjct: 374 MLQSPDWKYRHAGLMALSAIGEGCHQQMESILDETVNSVLLFLQDPHPRVRAAACTTLGQ 433

Query: 462 YAHWVVSQPPDMHLKPLMTELLKRILD-GNKRVQEAACSAFATLEEEACTELVPYLSYIL 520
            A            + ++  LL+ + + GN+RVQ  A SA     E+             
Sbjct: 434 MATDFAPNFQKKFHETVIAALLRTMENQGNQRVQSHAASALIIFIEDC------------ 481

Query: 521 DTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDL 580
                       K+LL+LY       DS+  +L+    I+  +  LI+   +L  E    
Sbjct: 482 -----------PKSLLVLY------VDSMVKNLHSVLVIK--LQELIRNGTKLALEQ--- 519

Query: 581 FPLLECLSSVATALQSGFLPYCE---PVYQRCVTL-VQKTL 617
             L+  ++SVA  ++  F+PY +   P  +  V L VQK L
Sbjct: 520 --LVTTIASVADTIEEKFVPYYDIFMPSLKHIVELAVQKEL 558



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 39/189 (20%), Positives = 74/189 (39%), Gaps = 23/189 (12%)

Query: 95  NNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKIC 154
           N +   S+L R   G+        G   + P     +  +L S D+        AL  I 
Sbjct: 343 NAVAAESALDRLACGL--------GGKVVLPMTKEHIMQMLQSPDWKYRHAGLMALSAIG 394

Query: 155 EDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNI-DT 213
           E   + ++S      L+  +   L F +   P++R+ A   + Q   D A        +T
Sbjct: 395 EGCHQQMESI-----LDETVNSVLLFLQDPHPRVRAAACTTLGQMATDFAPNFQKKFHET 449

Query: 214 FIEHLF-ALAVDDDPEVRKNVCRALVMLLE--------VRIDRLIPHMHSIIQYMLQRTQ 264
            I  L   +    +  V+ +   AL++ +E        + +D ++ ++HS++   LQ   
Sbjct: 450 VIAALLRTMENQGNQRVQSHAASALIIFIEDCPKSLLVLYVDSMVKNLHSVLVIKLQELI 509

Query: 265 DHDENVALE 273
            +   +ALE
Sbjct: 510 RNGTKLALE 518



 Score = 30.0 bits (66), Expect = 9.9
 Identities = 18/64 (28%), Positives = 31/64 (48%), Gaps = 2/64 (3%)

Query: 628 EQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFAL 687
           +  ++PD  +    L  LS + EG    +E ++  +    LLF  +QD  P VR ++   
Sbjct: 373 QMLQSPDWKYRHAGLMALSAIGEGCHQQMESILDETVNSVLLF--LQDPHPRVRAAACTT 430

Query: 688 LGDL 691
           LG +
Sbjct: 431 LGQM 434


>gi|198041777 Ran binding protein 11 isoform 1 [Homo sapiens]
          Length = 1015

 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 33/132 (25%), Positives = 61/132 (46%), Gaps = 6/132 (4%)

Query: 13  VLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKN 72
           VLQ+L  + S +TA  +  +++LKQ    P F + L+ + T   + D   R L+ L  K+
Sbjct: 50  VLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTN-HTLDINVRWLAVLYFKH 108

Query: 73  NVKAHYQSFPPPVAD-----FIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPEL 127
            +  +++   P          ++   + N  +  + I   I +LI  +A     + WPEL
Sbjct: 109 GIDRYWRRVAPHALSEEEKTTLRAGLITNFNEPINQIATQIAVLIAKVARLDCPRQWPEL 168

Query: 128 LPQLCNLLNSED 139
           +P L   +  +D
Sbjct: 169 IPTLIESVKVQD 180


>gi|39725950 Ran binding protein 11 isoform 2 [Homo sapiens]
          Length = 975

 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 33/132 (25%), Positives = 61/132 (46%), Gaps = 6/132 (4%)

Query: 13  VLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKN 72
           VLQ+L  + S +TA  +  +++LKQ    P F + L+ + T   + D   R L+ L  K+
Sbjct: 10  VLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTN-HTLDINVRWLAVLYFKH 68

Query: 73  NVKAHYQSFPPPVAD-----FIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPEL 127
            +  +++   P          ++   + N  +  + I   I +LI  +A     + WPEL
Sbjct: 69  GIDRYWRRVAPHALSEEEKTTLRAGLITNFNEPINQIATQIAVLIAKVARLDCPRQWPEL 128

Query: 128 LPQLCNLLNSED 139
           +P L   +  +D
Sbjct: 129 IPTLIESVKVQD 140


>gi|21361659 importin 9 [Homo sapiens]
          Length = 1041

 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 43/165 (26%), Positives = 75/165 (45%), Gaps = 11/165 (6%)

Query: 5   PDEQGLQQVL-QLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTR 63
           P  QGL++ L   L    SP    +   ++++K L    +F  +L   LT         R
Sbjct: 16  PVAQGLKEALVDTLTGILSPVQEVRAAAEEQIKVLEVTEEFGVHLA-ELTVDPQGALAIR 74

Query: 64  SLSGLILKNNVKAHY----QSFPPPV----ADFIKQECL-NNIGDASSLIRATIGILITT 114
            L+ +ILK  V+ H+    + F PP     A  + +E L N + ++ S +R+++   ++ 
Sbjct: 75  QLASVILKQYVETHWCAQSEKFRPPETTERAKIVIRELLPNGLRESISKVRSSVAYAVSA 134

Query: 115 IASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSE 159
           IA     + WP+L   L  +L S D N   GA   L +   + ++
Sbjct: 135 IAHWDWPEAWPQLFNLLMEMLVSGDLNAVHGAMRVLTEFTREVTD 179


>gi|29029559 CSE1 chromosome segregation 1-like protein [Homo
           sapiens]
          Length = 971

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 38/179 (21%), Positives = 77/179 (43%), Gaps = 11/179 (6%)

Query: 7   EQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRL-KSEDEPTRSL 65
           +  LQ + + LK +  P+ A +R  +   K L       NY + +LT L KS+D   +  
Sbjct: 5   DANLQTLTEYLKKTLDPDPAIRRPAE---KFLESVEGNQNYPLLLLTLLEKSQDNVIKVC 61

Query: 66  SGLILKNNVKAHY---QSFPPPVADF----IKQECLNNIGDASSLIRATIGILITTIASK 118
           + +  KN +K ++   +  P  + +     IK   ++ +  +   I+  +   I+ I  +
Sbjct: 62  ASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGRE 121

Query: 119 GELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKF 177
              Q WP+LL ++ N   S D++   G       + +       S+ L   + +++  F
Sbjct: 122 DFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAF 180


>gi|122937211 KIAA0368 protein [Homo sapiens]
          Length = 2017

 Score = 38.9 bits (89), Expect = 0.021
 Identities = 42/144 (29%), Positives = 68/144 (47%), Gaps = 12/144 (8%)

Query: 370  WNLRKCSAAALDVLANVFREEL---LPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCM 426
            WN RK +A   +V+A    E+L   LP L+P L    F P   ++++   +  A+     
Sbjct: 1267 WNSRKGAAFGFNVIATRAGEQLAPFLPQLVPRLYRYQFDPNLGIRQAMTSIWNALVTD-- 1324

Query: 427  QGMV-PYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPD--MHLKPLMTELL 483
            + MV  YL E++  L++ L+     VR  +C  L+        +P D  +   P + E L
Sbjct: 1325 KSMVDKYLKEILQDLVKNLTSNMWRVRESSCLALNDLLR---GRPLDDIIDKLPEIWETL 1381

Query: 484  KRILDGNKR-VQEAACSAFATLEE 506
             R+ D  K  V++AA  A  TL +
Sbjct: 1382 FRVQDDIKESVRKAAELALKTLSK 1405



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 29/120 (24%), Positives = 51/120 (42%), Gaps = 3/120 (2%)

Query: 405  HPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAH 464
            H  W  ++        IA    + + P+LP+L+P L +   D    +R     T    A 
Sbjct: 1264 HAMWNSRKGAAFGFNVIATRAGEQLAPFLPQLVPRLYRYQFDPNLGIRQ--AMTSIWNAL 1321

Query: 465  WVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAF-ATLEEEACTELVPYLSYILDTL 523
                   D +LK ++ +L+K +     RV+E++C A    L      +++  L  I +TL
Sbjct: 1322 VTDKSMVDKYLKEILQDLVKNLTSNMWRVRESSCLALNDLLRGRPLDDIIDKLPEIWETL 1381



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 28/118 (23%), Positives = 52/118 (44%), Gaps = 5/118 (4%)

Query: 392  LPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCL-----SD 446
            L  L+ + +  L    W +K  G + + +IA+     + PYL  ++  L+Q L     + 
Sbjct: 1697 LQELITITQKALQSQSWKMKAQGAIAMASIAKQTSSLVPPYLGMILTALLQGLAGRTWAG 1756

Query: 447  KKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATL 504
            K+ L+++IAC   +  A    S P       ++  +LK     N + +  A S  A +
Sbjct: 1757 KEELLKAIACVVTACSAELEKSVPNQPSTNEILQAVLKECSKENVKYKIVAISCAADI 1814


>gi|4507943 exportin 1 [Homo sapiens]
          Length = 1071

 Score = 37.7 bits (86), Expect = 0.048
 Identities = 30/141 (21%), Positives = 61/141 (43%), Gaps = 20/141 (14%)

Query: 446 DKKALVRSIACWTLSRY-----AHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSA 500
           D KA++ S   + + +Y     AHW         LK ++ +L + + + +  VQ+ AC  
Sbjct: 535 DNKAIIASNIMYIVGQYPRFLRAHW-------KFLKTVVNKLFEFMHETHDGVQDMACDT 587

Query: 501 FATLEEEA--------CTELVPYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHH 552
           F  + ++           E++P++  IL+ +       Q + +   Y+A+G +  +    
Sbjct: 588 FIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQ 647

Query: 553 LNQPEYIQKLMPPLIQKWNEL 573
             Q   I+K M    Q W+ +
Sbjct: 648 TVQEHLIEKYMLLPNQVWDSI 668


>gi|4504901 karyopherin alpha 4 [Homo sapiens]
          Length = 521

 Score = 37.7 bits (86), Expect = 0.048
 Identities = 55/227 (24%), Positives = 93/227 (40%), Gaps = 27/227 (11%)

Query: 370 WNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGC-MQG 428
           W L   + A  + +  V    ++PHL+PLL     H E  V+ + +  +G I  G   Q 
Sbjct: 264 WALSYLTDAGNEQIQMVIDSGIVPHLVPLLS----HQEVKVQTAALRAVGNIVTGTDEQT 319

Query: 429 MVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYA---HWVVSQPPDMHLKPLMTELLKR 485
            V    + + H    L+  K  +   A W LS         V    D +L P++  LL +
Sbjct: 320 QVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDK 379

Query: 486 ILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYDA--IG 543
              G+   Q+ A  A + L      + V YL  I   ++  F      NLL + DA  + 
Sbjct: 380 ---GDFGTQKEAAWAISNLTISGRKDQVAYL--IQQNVIPPF-----CNLLTVKDAQVVQ 429

Query: 544 TLADSVGHHLNQPEYIQKLMPPLIQKWNELK-------DEDKDLFPL 583
            + D + + L   E   + +  LI++   L+        E++D++ L
Sbjct: 430 VVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKL 476



 Score = 31.6 bits (70), Expect = 3.4
 Identities = 31/144 (21%), Positives = 64/144 (44%), Gaps = 7/144 (4%)

Query: 662 RSNIMTLLFQCMQ-DSMPEVRQSSFALLGDLTKACFIHVKPCI-AEFMPILGTNLNPEFI 719
           +S I+ +L  C++ D  P ++  +   L ++        +  + +  +P+    L+    
Sbjct: 112 KSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQ 171

Query: 720 SVCNNATWAIGEICMQMGAEMQPYVQM--VLNNLVEIINRPNTPKTLLEN-TAITIGRLG 776
           +VC  A WA+G I +  G + + YV    V+  L+  I+ P+ P T L N T + +    
Sbjct: 172 NVCEQAVWALGNI-IGDGPQCRDYVISLGVVKPLLSFIS-PSIPITFLRNVTWVMVNLCR 229

Query: 777 YVCPQEVAPMLQQFIRPWCTSLRN 800
           +  P      +Q+ +   C  + +
Sbjct: 230 HKDPPPPMETIQEILPALCVLIHH 253


>gi|55956788 nucleolin [Homo sapiens]
          Length = 710

 Score = 37.4 bits (85), Expect = 0.062
 Identities = 18/47 (38%), Positives = 25/47 (53%)

Query: 319 DVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAEDDDDDD 365
           D E+DE   + E +I+P   K+       E E  +  ED EDDDDD+
Sbjct: 156 DEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDE 202


>gi|6912478 karyopherin alpha 6 [Homo sapiens]
          Length = 536

 Score = 37.0 bits (84), Expect = 0.081
 Identities = 39/160 (24%), Positives = 64/160 (40%), Gaps = 13/160 (8%)

Query: 363 DDDALSD--WNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGA 420
           D D L+D  W L   S    + +  V    +   L+ LL     H ++ V    +  +G 
Sbjct: 265 DSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELL----MHNDYKVASPALRAVGN 320

Query: 421 IAEGC-MQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYA---HWVVSQPPDMHLK 476
           I  G  +Q  V      +P L+  LS  K  +R  ACWT+S         +    D ++ 
Sbjct: 321 IVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIF 380

Query: 477 PLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYL 516
           P++ E+L++      R ++ A  A          E + YL
Sbjct: 381 PVLIEILQK---AEFRTRKEAAWAITNATSGGTPEQIRYL 417


>gi|4507397 transcription factor 2 [Homo sapiens]
          Length = 557

 Score = 36.2 bits (82), Expect = 0.14
 Identities = 29/90 (32%), Positives = 38/90 (42%), Gaps = 13/90 (14%)

Query: 276 EFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKP 335
           E    L    + KEVL   L +L+P    G+K   + +    G          +E D KP
Sbjct: 11  ELLSALLSSGVTKEVLVQALEELLPSPNFGVKLETLPLSPGSG----------AEPDTKP 60

Query: 336 RFHKSRTVTLPHEAERPDGSEDAEDDDDDD 365
            FH   T+T  H   R  G E +ED DD D
Sbjct: 61  VFH---TLTNGHAKGRLSGDEGSEDGDDYD 87


>gi|54607053 GCN1 general control of amino-acid synthesis 1-like 1
            [Homo sapiens]
          Length = 2671

 Score = 36.2 bits (82), Expect = 0.14
 Identities = 31/121 (25%), Positives = 51/121 (42%), Gaps = 8/121 (6%)

Query: 379  ALDVLANVFREELLPH----LLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLP 434
            A D  A      L  H    +LP L   L    W  K   + +LGA+A    + +   LP
Sbjct: 1478 AADDCAKAVMSNLSAHGVKLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLP 1537

Query: 435  ELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQ 494
             ++P L + L+D    V+      L R    V+  P  + + P+   LL  + D +++ Q
Sbjct: 1538 NIVPKLTEVLTDSHVKVQKAGQQAL-RQIGSVIRNPEILAIAPV---LLDALTDPSRKTQ 1593

Query: 495  E 495
            +
Sbjct: 1594 K 1594



 Score = 31.2 bits (69), Expect = 4.5
 Identities = 35/145 (24%), Positives = 61/145 (42%), Gaps = 7/145 (4%)

Query: 373  RKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPY 432
            R  +A  L  L     E++LP ++P+L+  L   +   ++   + L  I +   +  V Y
Sbjct: 1942 RTIAARTLGDLVRKLGEKILPEIIPILEEGLRSQKSDERQGVCIGLSEIMKSTSRDAVLY 2001

Query: 433  LPE-LIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNK 491
              E L+P   + L D    VR  A  T  +    +  Q     L+ ++  LLK++ D  +
Sbjct: 2002 FSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQA----LEDILPFLLKQLDD--E 2055

Query: 492  RVQEAACSAFATLEEEACTELVPYL 516
             V E A      +       ++PYL
Sbjct: 2056 EVSEFALDGLKQVMAIKSRVVLPYL 2080


>gi|21361794 TIP120 protein [Homo sapiens]
          Length = 1230

 Score = 35.8 bits (81), Expect = 0.18
 Identities = 41/207 (19%), Positives = 82/207 (39%), Gaps = 29/207 (14%)

Query: 188 IRSHAIACVNQFIMDRAQALMDNIDTFIEHLFA-LAVDDDPEVRKNVCRALVMLLEVRID 246
           +R   I  +   +M     +  ++   IEHL + L+ +D     +   + +  +      
Sbjct: 191 VRKRTIIALGHLVMSCGNIVFVDL---IEHLLSELSKNDSMSTTRTYIQCIAAISRQAGH 247

Query: 247 RLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGM 306
           R+  ++  II  +++     D+ +     + + +   +  C + +  H+  +I I    +
Sbjct: 248 RIGEYLEKIIPLVVKFCNVDDDELREYCIQAFESFVRR--CPKEVYPHVSTIINIC---L 302

Query: 307 KYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAEDDDDDDA 366
           KY   D      D +EDE   D++                   +   GS+D   DDDD  
Sbjct: 303 KYLTYDPNYNYDDEDEDENAMDADGG----------------DDDDQGSDDEYSDDDD-- 344

Query: 367 LSDWNLRKCSAAALDVLANVFREELLP 393
              W +R+ +A  LD + +  R E+LP
Sbjct: 345 -MSWKVRRAAAKCLDAVVST-RHEMLP 369



 Score = 30.8 bits (68), Expect = 5.8
 Identities = 38/191 (19%), Positives = 71/191 (37%), Gaps = 28/191 (14%)

Query: 127  LLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSP 186
            LLP+L   L S           A++    D  + +D    N      I  FL+  +    
Sbjct: 966  LLPRLKGYLISGSSYARSSVVTAVKFTISDHPQPIDPLLKN-----CIGDFLKTLEDPDL 1020

Query: 187  KIRSHAIACVNQFIMDRAQALMDNIDTFIEHL------------------FALAVDDDPE 228
             +R  A+   N    ++   + D +DT + HL                  F   VDD  +
Sbjct: 1021 NVRRVALVTFNSAAHNKPSLIRDLLDTVLPHLYNETKVRKELIREVEMGPFKHTVDDGLD 1080

Query: 229  VRKNVCRALVMLLEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICK 288
            +RK     +  LL+  +DRL   +   + ++    +DH +   ++   F + +    +C 
Sbjct: 1081 IRKAAFECMYTLLDSCLDRL--DIFEFLNHVEDGLKDHYD---IKMLTFLMLVRLSTLCP 1135

Query: 289  EVLASHLVQLI 299
              +   L +L+
Sbjct: 1136 SAVLQRLDRLV 1146


>gi|32455246 beta isoform of regulatory subunit A, protein
           phosphatase 2 isoform a [Homo sapiens]
          Length = 601

 Score = 35.4 bits (80), Expect = 0.24
 Identities = 63/285 (22%), Positives = 116/285 (40%), Gaps = 56/285 (19%)

Query: 16  LLKDSQSPNTATQRIVQDK----LKQLNQFPD---FNNYLIFVLTRLKSEDEPTRSLS-- 66
           LL   ++  T  + +V+DK    L+Q++Q         Y + ++ RL S D  T   S  
Sbjct: 101 LLPPLENLATVEETVVRDKAVESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSAC 160

Query: 67  GLI----------LKNNVKAHYQSFPPPVADFIKQECLNNIGDASSL-----IRATIGIL 111
           GL           +K  ++  ++S        +++   + +G+ + +     +++ I  L
Sbjct: 161 GLFSVCYPRASNAVKAEIRQQFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPL 220

Query: 112 ITTIASKGELQ---MWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSS---------- 158
            T++AS  +     +  E    +  LL+ +D  T       L++  ED S          
Sbjct: 221 FTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETL--VMPTLRQAAEDKSWRVRYMVADR 278

Query: 159 --ELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQF-----IMDRAQALMDNI 211
             EL  +      LN +IP F    K C  ++R+ A   V +      I DR   +M+ I
Sbjct: 279 FSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQI 338

Query: 212 DTFIEHLFALAVDDDPEVRKNVCRALVMLL------EVRIDRLIP 250
             +I+ L    V D  +  K+   +++M L      E  I+ L+P
Sbjct: 339 LPYIKEL----VSDTNQHVKSALASVIMGLSTILGKENTIEHLLP 379


>gi|32455244 beta isoform of regulatory subunit A, protein
           phosphatase 2 isoform b [Homo sapiens]
          Length = 667

 Score = 35.4 bits (80), Expect = 0.24
 Identities = 63/285 (22%), Positives = 116/285 (40%), Gaps = 56/285 (19%)

Query: 16  LLKDSQSPNTATQRIVQDK----LKQLNQFPD---FNNYLIFVLTRLKSEDEPTRSLS-- 66
           LL   ++  T  + +V+DK    L+Q++Q         Y + ++ RL S D  T   S  
Sbjct: 101 LLPPLENLATVEETVVRDKAVESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSAC 160

Query: 67  GLI----------LKNNVKAHYQSFPPPVADFIKQECLNNIGDASSL-----IRATIGIL 111
           GL           +K  ++  ++S        +++   + +G+ + +     +++ I  L
Sbjct: 161 GLFSVCYPRASNAVKAEIRQQFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPL 220

Query: 112 ITTIASKGELQ---MWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSS---------- 158
            T++AS  +     +  E    +  LL+ +D  T       L++  ED S          
Sbjct: 221 FTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETL--VMPTLRQAAEDKSWRVRYMVADR 278

Query: 159 --ELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQF-----IMDRAQALMDNI 211
             EL  +      LN +IP F    K C  ++R+ A   V +      I DR   +M+ I
Sbjct: 279 FSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQI 338

Query: 212 DTFIEHLFALAVDDDPEVRKNVCRALVMLL------EVRIDRLIP 250
             +I+ L    V D  +  K+   +++M L      E  I+ L+P
Sbjct: 339 LPYIKEL----VSDTNQHVKSALASVIMGLSTILGKENTIEHLLP 379


>gi|27477070 BTAF1 RNA polymerase II, B-TFIID transcription
            factor-associated, 170kDa [Homo sapiens]
          Length = 1849

 Score = 35.4 bits (80), Expect = 0.24
 Identities = 31/117 (26%), Positives = 53/117 (45%), Gaps = 17/117 (14%)

Query: 385  NVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCL 444
            N+F E++LP L  +        + V +E  I  L  + E    G+VPY+  L+  ++  +
Sbjct: 1143 NIFLEKVLPWLGAI-------DDSVKQEGAIEALACVMEQLDVGIVPYIVLLVVPVLGRM 1195

Query: 445  SDKKALVRSIACWTLSRYAHWV-----VSQPPDM-----HLKPLMTELLKRILDGNK 491
            SD+   VR +A    +     +     +  PP+M      LK      L+++LDG K
Sbjct: 1196 SDQTDSVRFMATQCFATLIRLMPLEAGIPDPPNMSAELIQLKAKERHFLEQLLDGKK 1252



 Score = 33.9 bits (76), Expect = 0.69
 Identities = 30/132 (22%), Positives = 63/132 (47%), Gaps = 7/132 (5%)

Query: 152  KICEDSSELLDSDALNRPLNIM-IPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDN 210
            ++ E ++  +DS+    PL +  +P      ++ S  +R  A  CV   +M +  A M+ 
Sbjct: 1087 QVFETAAASMDSEL--HPLLVQHLPHLYMCLQYPSTAVRHMAARCVG--VMSKI-ATMET 1141

Query: 211  IDTFIEHLFA-LAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSIIQYMLQRTQDHDEN 269
            ++ F+E +   L   DD   ++    AL  ++E     ++P++  ++  +L R  D  ++
Sbjct: 1142 MNIFLEKVLPWLGAIDDSVKQEGAIEALACVMEQLDVGIVPYIVLLVVPVLGRMSDQTDS 1201

Query: 270  VALEACEFWLTL 281
            V   A + + TL
Sbjct: 1202 VRFMATQCFATL 1213



 Score = 30.4 bits (67), Expect = 7.6
 Identities = 24/86 (27%), Positives = 39/86 (45%), Gaps = 3/86 (3%)

Query: 431  PYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGN 490
            P L + +PHL  CL      VR +A   +   +     +  ++ L+ ++   L  I D  
Sbjct: 1102 PLLVQHLPHLYMCLQYPSTAVRHMAARCVGVMSKIATMETMNIFLEKVL-PWLGAIDDSV 1160

Query: 491  KRVQEAACSAFATLEEEACTELVPYL 516
            K  QE A  A A + E+    +VPY+
Sbjct: 1161 K--QEGAIEALACVMEQLDVGIVPYI 1184


>gi|154350213 hypothetical protein LOC79591 [Homo sapiens]
          Length = 689

 Score = 34.7 bits (78), Expect = 0.40
 Identities = 31/124 (25%), Positives = 58/124 (46%), Gaps = 15/124 (12%)

Query: 202 DRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSIIQYMLQ 261
           D+A+  M N+   +E L +L   +  E  K++C  L++ L    D +    ++I++Y++ 
Sbjct: 131 DKAELCMKNL---MESLDSLLCAEGSESLKSLCLKLLLCLVTVTDNI--SQNTILEYVMI 185

Query: 262 RTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVE 321
                  N   EA    L +   P  +       V L+ +LVN  KY  ++  ++K  + 
Sbjct: 186 -------NSIFEAI---LQILSHPPSRREHGYDAVVLLALLVNYRKYESVNPYIVKLSIV 235

Query: 322 EDEA 325
           +DEA
Sbjct: 236 DDEA 239


>gi|241982712 TBP-interacting protein isoform 1 [Homo sapiens]
          Length = 1236

 Score = 33.9 bits (76), Expect = 0.69
 Identities = 40/165 (24%), Positives = 69/165 (41%), Gaps = 24/165 (14%)

Query: 380 LDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMV--------- 430
           L  LA V    L  H+  L+ G++F    +   S    +   A   +QG++         
Sbjct: 460 LTELAGVLPGSLAEHMPVLVSGIIFS---LADRSSSSTIRMDALAFLQGLLGTEPAEAFH 516

Query: 431 PYLPELIPHLIQCLSDKKALVRSIACWTLSRY--AHWVVSQPPDMHLKPLMTELLK---- 484
           P+LP L+P ++ C++D    + + A   L     A W + +P  +  +P + E+      
Sbjct: 517 PHLPILLPPVMACVADSFYKIAAEALVVLQELVRALWPLHRPRMLDPEPYVGEMSAVTLA 576

Query: 485 --RILDGNKRVQEAACSAF----ATLEEEACTELVPYLSYILDTL 523
             R  D ++ V+E A S        L +    +L P L  +LD L
Sbjct: 577 RLRATDLDQEVKERAISCMGHLVGHLGDRLGDDLEPTLLLLLDRL 621


>gi|112420977 TBP-interacting protein isoform 2 [Homo sapiens]
          Length = 1119

 Score = 33.9 bits (76), Expect = 0.69
 Identities = 40/165 (24%), Positives = 69/165 (41%), Gaps = 24/165 (14%)

Query: 380 LDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMV--------- 430
           L  LA V    L  H+  L+ G++F    +   S    +   A   +QG++         
Sbjct: 367 LTELAGVLPGSLAEHMPVLVSGIIFS---LADRSSSSTIRMDALAFLQGLLGTEPAEAFH 423

Query: 431 PYLPELIPHLIQCLSDKKALVRSIACWTLSRY--AHWVVSQPPDMHLKPLMTELLK---- 484
           P+LP L+P ++ C++D    + + A   L     A W + +P  +  +P + E+      
Sbjct: 424 PHLPILLPPVMACVADSFYKIAAEALVVLQELVRALWPLHRPRMLDPEPYVGEMSAVTLA 483

Query: 485 --RILDGNKRVQEAACSAF----ATLEEEACTELVPYLSYILDTL 523
             R  D ++ V+E A S        L +    +L P L  +LD L
Sbjct: 484 RLRATDLDQEVKERAISCMGHLVGHLGDRLGDDLEPTLLLLLDRL 528


>gi|89886480 zinedin isoform 2 [Homo sapiens]
          Length = 760

 Score = 33.9 bits (76), Expect = 0.69
 Identities = 16/50 (32%), Positives = 31/50 (62%), Gaps = 1/50 (2%)

Query: 322 EDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAEDDDDDDALSDWN 371
           EDE   D + ++    HK + V LP +A  P+  ++ E+DD +DA+++++
Sbjct: 272 EDED-SDEDDELDSVQHKKQRVKLPSKALVPEMEDEDEEDDSEDAINEFD 320


>gi|89886477 zinedin isoform 1 [Homo sapiens]
          Length = 753

 Score = 33.9 bits (76), Expect = 0.69
 Identities = 16/50 (32%), Positives = 31/50 (62%), Gaps = 1/50 (2%)

Query: 322 EDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAEDDDDDDALSDWN 371
           EDE   D + ++    HK + V LP +A  P+  ++ E+DD +DA+++++
Sbjct: 272 EDED-SDEDDELDSVQHKKQRVKLPSKALVPEMEDEDEEDDSEDAINEFD 320


>gi|54112117 splicing factor 3b, subunit 1 isoform 1 [Homo sapiens]
          Length = 1304

 Score = 33.9 bits (76), Expect = 0.69
 Identities = 33/116 (28%), Positives = 56/116 (48%), Gaps = 11/116 (9%)

Query: 369 DWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPE-WVVKESGILVLG--AIAEGC 425
           D  +R  +A A  V+A+      +P LLP LK +    + W  + +GI ++   AI  GC
Sbjct: 621 DEYVRNTTARAFAVVASALG---IPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGC 677

Query: 426 MQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVS---QPPDMHLKPL 478
              ++P+L  L+  +   L D++  VR+I+   ++  A        +  D  LKPL
Sbjct: 678 --AILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYGIESFDSVLKPL 731


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,241,237
Number of Sequences: 37866
Number of extensions: 1512218
Number of successful extensions: 5048
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 4833
Number of HSP's gapped (non-prelim): 203
length of query: 887
length of database: 18,247,518
effective HSP length: 111
effective length of query: 776
effective length of database: 14,044,392
effective search space: 10898448192
effective search space used: 10898448192
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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