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Search of human proteins with 48476182
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
(1386 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 2834 0.0
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 1041 0.0
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 1040 0.0
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 972 0.0
gi|224994173 roundabout 1 isoform d [Homo sapiens] 970 0.0
gi|19743806 roundabout 1 isoform b [Homo sapiens] 959 0.0
gi|4506569 roundabout 1 isoform a [Homo sapiens] 958 0.0
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 956 0.0
gi|224994171 roundabout 1 isoform c [Homo sapiens] 950 0.0
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 228 2e-59
gi|118572606 hemicentin 1 [Homo sapiens] 220 8e-57
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 215 2e-55
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 215 2e-55
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 215 2e-55
gi|222352127 sidekick 2 [Homo sapiens] 213 8e-55
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 208 3e-53
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 208 3e-53
gi|157311649 neogenin homolog 1 [Homo sapiens] 207 7e-53
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 200 9e-51
gi|109150416 peroxidasin [Homo sapiens] 199 1e-50
gi|75709184 contactin 3 [Homo sapiens] 199 2e-50
gi|119220552 sidekick 1 [Homo sapiens] 194 4e-49
gi|4827022 contactin 2 precursor [Homo sapiens] 193 8e-49
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 185 3e-46
gi|126517478 peroxidasin homolog-like [Homo sapiens] 185 3e-46
gi|237858680 neurofascin isoform 5 precursor [Homo sapiens] 184 7e-46
gi|237858675 neurofascin isoform 1 precursor [Homo sapiens] 184 7e-46
gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens] 182 3e-45
gi|237858682 neurofascin isoform 6 precursor [Homo sapiens] 179 1e-44
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 178 3e-44
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 2834 bits (7347), Expect = 0.0
Identities = 1386/1386 (100%), Positives = 1386/1386 (100%)
Query: 1 MLRYLLKTLLQMNLFADSLAGDISNSSELLLGFNSSLAALNHTLLPPGDPSLNGSRVGPE 60
MLRYLLKTLLQMNLFADSLAGDISNSSELLLGFNSSLAALNHTLLPPGDPSLNGSRVGPE
Sbjct: 1 MLRYLLKTLLQMNLFADSLAGDISNSSELLLGFNSSLAALNHTLLPPGDPSLNGSRVGPE 60
Query: 61 DAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPS 120
DAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPS
Sbjct: 61 DAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPS 120
Query: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVG 180
GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVG
Sbjct: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVG 180
Query: 181 EPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASN 240
EPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASN
Sbjct: 181 EPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASN 240
Query: 241 MAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT 300
MAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT
Sbjct: 241 MAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT 300
Query: 301 GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAP 360
GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAP
Sbjct: 301 GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAP 360
Query: 361 GESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAG 420
GESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAG
Sbjct: 361 GESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAG 420
Query: 421 YYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQP 480
YYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQP
Sbjct: 421 YYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQP 480
Query: 481 SVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMRE 540
SVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMRE
Sbjct: 481 SVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMRE 540
Query: 541 DWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGN 600
DWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGN
Sbjct: 541 DWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGN 600
Query: 601 TWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVED 660
TWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVED
Sbjct: 601 TWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVED 660
Query: 661 PWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAGPEGGSWTMLD 720
PWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAGPEGGSWTMLD
Sbjct: 661 PWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAGPEGGSWTMLD 720
Query: 721 LQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALG 780
LQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALG
Sbjct: 721 LQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALG 780
Query: 781 GDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGWARSAMLRGLVPGLL 840
GDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGWARSAMLRGLVPGLL
Sbjct: 781 GDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGWARSAMLRGLVPGLL 840
Query: 841 YRTLVAAATSAGVGVPSAPVLVQLPSPPDLEPGLEVGAGLAVRLARVLREPAFLAGSGAA 900
YRTLVAAATSAGVGVPSAPVLVQLPSPPDLEPGLEVGAGLAVRLARVLREPAFLAGSGAA
Sbjct: 841 YRTLVAAATSAGVGVPSAPVLVQLPSPPDLEPGLEVGAGLAVRLARVLREPAFLAGSGAA 900
Query: 901 CGALLLGLCAALYWRRKQRKELSHYTASFAYTPAVSFPHSEGLSGASSRPPMGLGPAPYS 960
CGALLLGLCAALYWRRKQRKELSHYTASFAYTPAVSFPHSEGLSGASSRPPMGLGPAPYS
Sbjct: 901 CGALLLGLCAALYWRRKQRKELSHYTASFAYTPAVSFPHSEGLSGASSRPPMGLGPAPYS 960
Query: 961 WLADSWPHPSRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGTAAPGEGPVYS 1020
WLADSWPHPSRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGTAAPGEGPVYS
Sbjct: 961 WLADSWPHPSRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGTAAPGEGPVYS 1020
Query: 1021 TIDPAGEELQTFHGGFPQHPSGDLGPWSQYAPPEWSQGDSGAKGGKVKLLGKPVQMPSLN 1080
TIDPAGEELQTFHGGFPQHPSGDLGPWSQYAPPEWSQGDSGAKGGKVKLLGKPVQMPSLN
Sbjct: 1021 TIDPAGEELQTFHGGFPQHPSGDLGPWSQYAPPEWSQGDSGAKGGKVKLLGKPVQMPSLN 1080
Query: 1081 WPEALPPPPPSCELSCLEGPEEELEGSSEPEEWCPPMPERSHLTEPSSSGGCLVTPSRRE 1140
WPEALPPPPPSCELSCLEGPEEELEGSSEPEEWCPPMPERSHLTEPSSSGGCLVTPSRRE
Sbjct: 1081 WPEALPPPPPSCELSCLEGPEEELEGSSEPEEWCPPMPERSHLTEPSSSGGCLVTPSRRE 1140
Query: 1141 TPSPTPSYGQQSTATLTPSPPDPPQPPTDMPHLHQMPRRVPLGPSSPLSVSQPMLGIREA 1200
TPSPTPSYGQQSTATLTPSPPDPPQPPTDMPHLHQMPRRVPLGPSSPLSVSQPMLGIREA
Sbjct: 1141 TPSPTPSYGQQSTATLTPSPPDPPQPPTDMPHLHQMPRRVPLGPSSPLSVSQPMLGIREA 1200
Query: 1201 RPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQGPRARFRKKPKALPYRR 1260
RPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQGPRARFRKKPKALPYRR
Sbjct: 1201 RPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQGPRARFRKKPKALPYRR 1260
Query: 1261 ENSPGDLPPPPLPPPEEEASWALELRAAGSMSSLERERSGERKAVQAVPLAAQRVLHPDE 1320
ENSPGDLPPPPLPPPEEEASWALELRAAGSMSSLERERSGERKAVQAVPLAAQRVLHPDE
Sbjct: 1261 ENSPGDLPPPPLPPPEEEASWALELRAAGSMSSLERERSGERKAVQAVPLAAQRVLHPDE 1320
Query: 1321 EAWLPYSRPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGRSRSRSQSRSQSQRPGQK 1380
EAWLPYSRPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGRSRSRSQSRSQSQRPGQK
Sbjct: 1321 EAWLPYSRPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGRSRSRSQSRSQSQRPGQK 1380
Query: 1381 RREEPR 1386
RREEPR
Sbjct: 1381 RREEPR 1386
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 1041 bits (2691), Expect = 0.0
Identities = 602/1381 (43%), Positives = 804/1381 (58%), Gaps = 121/1381 (8%)
Query: 52 LNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDP 111
++GSR+ ED PRIVE P D++VS+GEP TL C+AEGRP P IEWYK+G RV T ++DP
Sbjct: 19 VDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDP 78
Query: 112 RAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQS 171
R+HR+LLPSG+LFF RIVHGRR++PDEG Y CVARNYLG A SRNASLEVA+LRDDFRQ+
Sbjct: 79 RSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQN 138
Query: 172 PGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDA 231
P +VVVA GEPA+LEC PPRGHPEP++ W+KD R+ ++E RI+IRGGKLM+S+T KSDA
Sbjct: 139 PTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDA 198
Query: 232 GMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRW 291
GMY CV +NM GER+S AE+ V ERP+FLRRP+NQVVL + V F C+V+GDP P +RW
Sbjct: 199 GMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRW 258
Query: 292 RKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVT 351
+K+D +LP GRY+I+ D++L I + DEGTY C+AEN VG+ EAS +L+V PPQ V
Sbjct: 259 KKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVV 318
Query: 352 QPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNI 411
+P+DQ+ A G +V F CETKGNP PA+FWQKEGSQ LLFP+Q QP R SVSP G L I
Sbjct: 319 RPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTI 378
Query: 412 TAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLP 471
T +QR DAGYY+CQA++VAGSILAKA LE+ D PP+ILQGPANQTL + + L
Sbjct: 379 TNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLK 438
Query: 472 CRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEAT 531
C+ TG+P P + W K+G G D + GTL I N++ D G Y+CVA SS+GE +
Sbjct: 439 CKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETS 498
Query: 532 WSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVI 591
WS L + E G + + S PG PS+P VT++TKNS+TL+W+P ++Y+I
Sbjct: 499 WSAVLDVTES-GATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYII 557
Query: 592 EAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQD 651
EAFS + N+W+TVA+ V+ +TV GL+PNTIYLF+VRA+ GLS+PSP+S+PVRTQD
Sbjct: 558 EAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQD 617
Query: 652 SSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWR-VAG 710
SP D + Q+ L +V VRL P+VL P T+QV+WTVD Q +QG+RV +R +G
Sbjct: 618 ISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSG 677
Query: 711 PEG-GSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPS 769
+ SW LD + P+++S VL L G +IKV+ E G +S S T EEAPS
Sbjct: 678 LQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPS 737
Query: 770 GPPQGVAVALGGDGNS-SITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGWAR 828
PPQ V V G NS SI+VSW+PP P QNG+I EY+IWCLGNE+RFH+N++ R
Sbjct: 738 APPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIR 797
Query: 829 SAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPDLEPGLEVGAGLAVRLARVL 888
S ++ GL PG+ YR VAA+TSAGVGV S P + + ++ E + ++ V+
Sbjct: 798 SVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVI-TENNNSITEQITDVV 856
Query: 889 REPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTASFAYTPAVSFPHSE-GLSGAS 947
++PAF+AG G AC +L+G LYWRRK+RK LS+Y AV+F + GL
Sbjct: 857 KQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNY--------AVTFQRGDGGLMSNG 908
Query: 948 SRPP-MGLGPAPYSWLADSWPHPSRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLYLAQT 1006
SRP + G Y WLADSWP S + S P+ + + Q
Sbjct: 909 SRPGLLNAGDPSYPWLADSWPATSLPVNNSN-------SGPNEIGNFGRGDVLPPVPGQG 961
Query: 1007 ARGTAAPGEGPVYSTIDPAGE----------------ELQTFHGGFPQHPSGDL--GPWS 1048
+ +G +YS+ID + Q H + DL W
Sbjct: 962 DKTATMLSDGAIYSSIDFTTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWK 1021
Query: 1049 Q------------YAPPEWSQGDSGAKGGKVKL---LGKPVQMPSLNWPEALPPPPPSCE 1093
Y+ P+ ++G++G KGGK K KP + W PPPP
Sbjct: 1022 SSIQQKTDLMGFGYSLPDQNKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPP--- 1078
Query: 1094 LSCLEGPE------EELEGSSEPEEWCPPMPERSHLTE------PSSSGGCLVTPSRRET 1141
+ L G E E+ E + + WCPP+P +++L + P R
Sbjct: 1079 VQPLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVA 1138
Query: 1142 PSPTPSYGQQSTATLTPSPPDPPQPPTDMPHLHQMPR-----------------RVPLGP 1184
SP S+GQQSTATLTPSP + QP HL ++ R + P P
Sbjct: 1139 SSPAISFGQQSTATLTPSPREEMQPML-QAHLDELTRAYQFDIAKQTWHIQSNNQPPQPP 1197
Query: 1185 SSPLS-VSQPMLGIREARPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQ 1243
PL VS ++ E A A P P PG + + +
Sbjct: 1198 VPPLGYVSGALISDLETDVADDDADDEEEALEIPRPL-RALDQTPGSSMD---NLDSSVT 1253
Query: 1244 GPRARFRKKPKALPYRRENSPGDLPPPPLPPPEEEASWALELRAAGSMSSLERERSGERK 1303
G ++P+ P P +++ + L + ++ + G
Sbjct: 1254 GKAFTSSQRPR----------------PTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMD 1297
Query: 1304 AVQAVPLAAQRVLHPDEEAWLPYSRPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGR 1363
A+P +R DEEA +PYS+PSF S G +SS G++SS+GS GP +
Sbjct: 1298 QQPALP--HRREGMTDEEALVPYSKPSFPS----------PGGHSSSGTASSKGSTGPRK 1345
Query: 1364 S 1364
+
Sbjct: 1346 T 1346
Score = 85.5 bits (210), Expect = 3e-16
Identities = 59/204 (28%), Positives = 94/204 (46%), Gaps = 18/204 (8%)
Query: 334 RAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQ 393
R + S PP++V P D + + GE C+ +G P P I W K+G +V +
Sbjct: 18 RVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERV---ETD 74
Query: 394 SLQPTGRFSVSPRGQLNITAVQRG-----DAGYYVCQAVSVAGSILAK-ALLEIKGASLD 447
P + P G L + G D G YVC A + G +++ A LE+ D
Sbjct: 75 KDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD 134
Query: 448 GLPPVILQGPANQTLVLGSSVWLPCR-VTGNPQPSVRWKKDGQWLQGDDLQFK-TMANGT 505
Q P + + G L C+ G+P+P++ WKKD ++ DD + + ++ G
Sbjct: 135 -----FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDK--VRIDDKEERISIRGGK 187
Query: 506 LYIANVQEMDMGFYSCVAKSSTGE 529
L I+N ++ D G Y+CV + GE
Sbjct: 188 LMISNTRKSDAGMYTCVGTNMVGE 211
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 1040 bits (2690), Expect = 0.0
Identities = 603/1385 (43%), Positives = 804/1385 (58%), Gaps = 121/1385 (8%)
Query: 48 GDPSLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATV 107
G+ GSR+ ED PRIVE P D++VS+GEP TL C+AEGRP P IEWYK+G RV T
Sbjct: 31 GNGQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETD 90
Query: 108 REDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDD 167
++DPR+HR+LLPSG+LFF RIVHGRR++PDEG Y CVARNYLG A SRNASLEVA+LRDD
Sbjct: 91 KDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD 150
Query: 168 FRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTL 227
FRQ+P +VVVA GEPA+LEC PPRGHPEP++ W+KD R+ ++E RI+IRGGKLM+S+T
Sbjct: 151 FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTR 210
Query: 228 KSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPP 287
KSDAGMY CV +NM GER+S AE+ V ERP+FLRRP+NQVVL + V F C+V+GDP P
Sbjct: 211 KSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQP 270
Query: 288 RLRWRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPP 347
+RW+K+D +LP GRY+I+ D++L I + DEGTY C+AEN VG+ EAS +L+V PP
Sbjct: 271 TVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPP 330
Query: 348 QLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRG 407
Q V +P+DQ+ A G +V F CETKGNP PA+FWQKEGSQ LLFP+Q QP R SVSP G
Sbjct: 331 QFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTG 390
Query: 408 QLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSS 467
L IT +QR DAGYY+CQA++VAGSILAKA LE+ D PP+ILQGPANQTL + +
Sbjct: 391 DLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGT 450
Query: 468 VWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSST 527
L C+ TG+P P + W K+G G D + GTL I N++ D G Y+CVA SS+
Sbjct: 451 ALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSS 510
Query: 528 GEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVT 587
GE +WS L + E G + + S PG PS+P VT++TKNS+TL+W+P +
Sbjct: 511 GETSWSAVLDVTES-GATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPAS 569
Query: 588 SYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPV 647
+Y+IEAFS + N+W+TVA+ V+ +TV GL+PNTIYLF+VRA+ GLS+PSP+S+PV
Sbjct: 570 AYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPV 629
Query: 648 RTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWR 707
RTQD SP D + Q+ L +V VRL P+VL P T+QV+WTVD Q +QG+RV +R
Sbjct: 630 RTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYR 689
Query: 708 -VAGPEG-GSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPE 765
+G + SW LD + P+++S VL L G +IKV+ E G +S S T E
Sbjct: 690 QTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTE 749
Query: 766 EAPSGPPQGVAVALGGDGNS-SITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAA 824
EAPS PPQ V V G NS SI+VSW+PP P QNG+I EY+IWCLGNE+RFH+N++
Sbjct: 750 EAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVD 809
Query: 825 GWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPDLEPGLEVGAGLAVRL 884
RS ++ GL PG+ YR VAA+TSAGVGV S P + + ++ E + ++
Sbjct: 810 AAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVI-TENNNSITEQI 868
Query: 885 ARVLREPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTASFAYTPAVSFPHSE-GL 943
V+++PAF+AG G AC +L+G LYWRRK+RK LS+Y AV+F + GL
Sbjct: 869 TDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNY--------AVTFQRGDGGL 920
Query: 944 SGASSRPP-MGLGPAPYSWLADSWPHPSRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLY 1002
SRP + G Y WLADSWP S + S P+ + +
Sbjct: 921 MSNGSRPGLLNAGDPSYPWLADSWPATSLPVNNSN-------SGPNEIGNFGRGDVLPPV 973
Query: 1003 LAQTARGTAAPGEGPVYSTIDPAGE----------------ELQTFHGGFPQHPSGDL-- 1044
Q + +G +YS+ID + Q H + DL
Sbjct: 974 PGQGDKTATMLSDGAIYSSIDFTTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPD 1033
Query: 1045 GPWSQ------------YAPPEWSQGDSGAKGGKVKL---LGKPVQMPSLNWPEALPPPP 1089
W Y+ P+ ++G++G KGGK K KP + W PPP
Sbjct: 1034 PQWKSSIQQKTDLMGFGYSLPDQNKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPP 1093
Query: 1090 PSCELSCLEGPE------EELEGSSEPEEWCPPMPERSHLTE------PSSSGGCLVTPS 1137
P + L G E E+ E + + WCPP+P +++L + P
Sbjct: 1094 P---VQPLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPV 1150
Query: 1138 RRETPSPTPSYGQQSTATLTPSPPDPPQPPTDMPHLHQMPR-----------------RV 1180
R SP S+GQQSTATLTPSP + QP HL ++ R +
Sbjct: 1151 RGVASSPAISFGQQSTATLTPSPREEMQPML-QAHLDELTRAYQFDIAKQTWHIQSNNQP 1209
Query: 1181 PLGPSSPLS-VSQPMLGIREARPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMT 1239
P P PL VS ++ E A A P P PG + +
Sbjct: 1210 PQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPL-RALDQTPGSSMD---NLD 1265
Query: 1240 PPLQGPRARFRKKPKALPYRRENSPGDLPPPPLPPPEEEASWALELRAAGSMSSLERERS 1299
+ G ++P+ P P +++ + L + ++ +
Sbjct: 1266 SSVTGKAFTSSQRPR----------------PTSPFSTDSNTSAALSQSQRPRPTKKHKG 1309
Query: 1300 GERKAVQAVPLAAQRVLHPDEEAWLPYSRPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSR 1359
G A+P +R DEEA +PYS+PSF S G +SS G++SS+GS
Sbjct: 1310 GRMDQQPALP--HRREGMTDEEALVPYSKPSFPS----------PGGHSSSGTASSKGST 1357
Query: 1360 GPGRS 1364
GP ++
Sbjct: 1358 GPRKT 1362
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 972 bits (2513), Expect = 0.0
Identities = 541/1201 (45%), Positives = 730/1201 (60%), Gaps = 72/1201 (5%)
Query: 53 NGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPR 112
+GSR+ ED PRIVE P DL+VS+GEPATL C+AEGRP P IEWYK G RV T ++DPR
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 77
Query: 113 AHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSP 172
+HR+LLPSG+LFF RIVHGR++RPDEGVY CVARNYLG A S NASLEVA+LRDDFRQ+P
Sbjct: 78 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
Query: 173 GNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAG 232
+V+VAVGEPAV+EC PPRGHPEP++SW+KDG+ L +++ RITIRGGKLM+++T KSDAG
Sbjct: 138 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 197
Query: 233 MYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWR 292
YVCV +NM GERES AE+ VLERPSF++RP N V D F CE +GDP P +RWR
Sbjct: 198 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 293 KEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHV---PPQL 349
K+DGELP RYEIR DH+L I V+A D G+YTCVAEN VG+AEAS +L+V V PP
Sbjct: 258 KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
Query: 350 VTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQL 409
V +P+DQ+ A G +V FQCE GNP PAIFW++EGSQ LLF Q Q + RFSVS G L
Sbjct: 318 VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 410 NITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVW 469
IT VQR D GYY+CQ ++VAGSI+ KA LE+ D PPVI QGP NQT+ + +
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 437
Query: 470 LPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGE 529
L C TG+P P++ W+KDG + D + K + NG L I + D G Y+C+A + +GE
Sbjct: 438 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 497
Query: 530 ATWSGWLKMRE-DWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTS 588
ATWS +++++E V P PT+P+ P APS+P VT++++N++TL+W+PN +GA TS
Sbjct: 498 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS 557
Query: 589 YVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVR 648
Y+IEAFS A+G++W+TVA+ V+ ET + GL+PN IYLFLVRA A+G+S+PS +S+PV+
Sbjct: 558 YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 617
Query: 649 TQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRV 708
TQD P+ D + Q+ L + L P VL +++V WTVD Q +QG+++ +R
Sbjct: 618 TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP 677
Query: 709 AGPEGG--SWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEE 766
+G G W + ++++P++ S V+ L G +IK + E GA+S EE
Sbjct: 678 SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE 737
Query: 767 APSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGW 826
APS PPQGV V+ ++I VSW+PP QNG++ EY++WCLGNE+R+H+N++ G
Sbjct: 738 APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 797
Query: 827 ARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPD-LEPGLEVGAGLAVRLA 885
S ++ LVPG+ Y VAA+T AG GV S P +QL + + + P E LA +++
Sbjct: 798 TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSP--EDQVSLAQQIS 855
Query: 886 RVLREPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTA------SFAYTPAVSFPH 939
V+++PAF+AG GAAC +L+ LY RK+R L+ A SF +TP V++
Sbjct: 856 DVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQR 915
Query: 940 SEGLSGASSRPPMGL----GPAPYSWLADSWPHPSRSPSAQEPRGSCCPS---NPDPDDR 992
+ RP GL PA WLAD+WP+ + + + SCC + N D +
Sbjct: 916 GGEAVSSGGRP--GLLNISEPAAQPWLADTWPNTGNNHN--DCSISCCTAGNGNSDSNLT 971
Query: 993 YYNEAG-------ISLYLAQT------ARGTAAPGE-------------GPVYSTIDPAG 1026
Y+ + L Q+ G+ GE PV I
Sbjct: 972 TYSRPADWQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQN 1031
Query: 1027 EELQTFHGG------FPQHPSGDLGPWSQYAPPEWSQGDSGAKGGKV-KLLGKPVQMPSL 1079
+ + + P + S D Y + SG++G K K + +
Sbjct: 1032 KLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGM 1091
Query: 1080 NWPEALPPPPP-SCELSCLEGPEEELEGSSEPEEWCPPMPERSHL----TEPSSSGGCLV 1134
NW + LPPPP S E ++ S + E CP P R++L E
Sbjct: 1092 NWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARTYLQQDELEEEEDERGPT 1151
Query: 1135 TPSRRETPSPTP-SYGQQSTATLTPSPPDPPQP-----PTDMPHLHQMP--RRVPLGPSS 1186
P R SP SY QSTATLTPSP + QP P + H+ P RR P+ P
Sbjct: 1152 PPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP 1211
Query: 1187 P 1187
P
Sbjct: 1212 P 1212
Score = 42.0 bits (97), Expect = 0.004
Identities = 61/223 (27%), Positives = 86/223 (38%), Gaps = 65/223 (29%)
Query: 1196 GIREARPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQGPRARFRKKPKA 1255
G++ AR A H S P P++ S + T P + + + +P
Sbjct: 1326 GLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAK----KLKHQPGH 1381
Query: 1256 LPYRRENSPGDLPPPPLPPPEEEASWA-----LELR--AAGSMSSLER--ERSGERKAV- 1305
L RRE DLPPPP+PPP ++ A LE+R + S++ +RS +RK
Sbjct: 1382 L--RRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSS 1439
Query: 1306 ----------QAVPL-----------------------AAQRVLHPD-----EEAWLPYS 1327
Q V + AA+R L P +E LPY
Sbjct: 1440 YKGREVLGGRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYC 1499
Query: 1328 RPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGRSRSRSQS 1370
RP+F T+ + SSSS SRG G SR R Q+
Sbjct: 1500 RPTF----------PTSNNPRDPSSSSSMSSRGSG-SRQREQA 1531
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 970 bits (2508), Expect = 0.0
Identities = 539/1193 (45%), Positives = 726/1193 (60%), Gaps = 67/1193 (5%)
Query: 53 NGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPR 112
+GSR+ ED PRIVE P DL+VS+GEPATL C+AEGRP P IEWYK G RV T ++DPR
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 77
Query: 113 AHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSP 172
+HR+LLPSG+LFF RIVHGR++RPDEGVY CVARNYLG A S NASLEVA+LRDDFRQ+P
Sbjct: 78 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
Query: 173 GNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAG 232
+V+VAVGEPAV+EC PPRGHPEP++SW+KDG+ L +++ RITIRGGKLM+++T KSDAG
Sbjct: 138 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 197
Query: 233 MYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWR 292
YVCV +NM GERES AE+ VLERPSF++RP N V D F CE +GDP P +RWR
Sbjct: 198 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 293 KEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHV---PPQL 349
K+DGELP RYEIR DH+L I V+A D G+YTCVAEN VG+AEAS +L+V V PP
Sbjct: 258 KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
Query: 350 VTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQL 409
V +P+DQ+ A G +V FQCE GNP PAIFW++EGSQ LLF Q Q + RFSVS G L
Sbjct: 318 VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 410 NITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVW 469
IT VQR D GYY+CQ ++VAGSI+ KA LE+ D PPVI QGP NQT+ + +
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 437
Query: 470 LPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGE 529
L C TG+P P++ W+KDG + D + K + NG L I + D G Y+C+A + +GE
Sbjct: 438 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 497
Query: 530 ATWSGWLKMRE-DWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTS 588
ATWS +++++E V P PT+P+ P APS+P VT++++N++TL+W+PN +GA TS
Sbjct: 498 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS 557
Query: 589 YVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVR 648
Y+IEAFS A+G++W+TVA+ V+ ET + GL+PN IYLFLVRA A+G+S+PS +S+PV+
Sbjct: 558 YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 617
Query: 649 TQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRV 708
TQD P+ D + Q+ L + L P VL +++V WTVD Q +QG+++ +R
Sbjct: 618 TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP 677
Query: 709 AGPEGG--SWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEE 766
+G G W + ++++P++ S V+ L G +IK + E GA+S EE
Sbjct: 678 SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE 737
Query: 767 APSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGW 826
APS PPQGV V+ ++I VSW+PP QNG++ EY++WCLGNE+R+H+N++ G
Sbjct: 738 APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 797
Query: 827 ARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPD-LEPGLEVGAGLAVRLA 885
S ++ LVPG+ Y VAA+T AG GV S P +QL + + + P E LA +++
Sbjct: 798 TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSP--EDQVSLAQQIS 855
Query: 886 RVLREPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTASFAYTPAVSFPHSEGLSG 945
V+++PAF+AG GAAC +L+ LY RK+R L T+++A V++
Sbjct: 856 DVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGL---TSTYAGIRKVTYQRGGEAVS 912
Query: 946 ASSRPPMGL----GPAPYSWLADSWPHPSRSPSAQEPRGSCCPS---NPDPDDRYYNEAG 998
+ RP GL PA WLAD+WP+ + + + SCC + N D + Y+ G
Sbjct: 913 SGGRP--GLLNISEPAAQPWLADTWPNTGNNHN--DCSISCCTAGNGNSDSNLTTYSRPG 968
Query: 999 ISLYLAQTA-----------RGTAAPGE-------------GPVYSTIDPAGEELQTFHG 1034
A T G+ GE PV I + + +
Sbjct: 969 QPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRA 1028
Query: 1035 G------FPQHPSGDLGPWSQYAPPEWSQGDSGAKGGKV-KLLGKPVQMPSLNWPEALPP 1087
P + S D Y + SG++G K K + +NW + LPP
Sbjct: 1029 NDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPP 1088
Query: 1088 PPP-SCELSCLEGPEEELEGSSEPEEWCPPMPERSHL----TEPSSSGGCLVTPSRRETP 1142
PP S E ++ S + E CP P R +L E P R
Sbjct: 1089 PPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAAS 1148
Query: 1143 SPTP-SYGQQSTATLTPSPPDPPQP-----PTDMPHLHQMP--RRVPLGPSSP 1187
SP SY QSTATLTPSP + QP P + H+ P RR P+ P P
Sbjct: 1149 SPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPP 1201
Score = 42.0 bits (97), Expect = 0.004
Identities = 61/223 (27%), Positives = 86/223 (38%), Gaps = 65/223 (29%)
Query: 1196 GIREARPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQGPRARFRKKPKA 1255
G++ AR A H S P P++ S + T P + + + +P
Sbjct: 1315 GLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAK----KLKHQPGH 1370
Query: 1256 LPYRRENSPGDLPPPPLPPPEEEASWA-----LELR--AAGSMSSLER--ERSGERKAV- 1305
L RRE DLPPPP+PPP ++ A LE+R + S++ +RS +RK
Sbjct: 1371 L--RRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSS 1428
Query: 1306 ----------QAVPL-----------------------AAQRVLHPD-----EEAWLPYS 1327
Q V + AA+R L P +E LPY
Sbjct: 1429 YKGREVLDGRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYC 1488
Query: 1328 RPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGRSRSRSQS 1370
RP+F T+ + SSSS SRG G SR R Q+
Sbjct: 1489 RPTF----------PTSNNPRDPSSSSSMSSRGSG-SRQREQA 1520
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 959 bits (2478), Expect = 0.0
Identities = 550/1252 (43%), Positives = 742/1252 (59%), Gaps = 124/1252 (9%)
Query: 53 NGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPR 112
+GSR+ ED PRIVE P DL+VS+GEPATL C+AEGRP P IEWYK G RV T ++DPR
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 77
Query: 113 AHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSP 172
+HR+LLPSG+LFF RIVHGR++RPDEGVY CVARNYLG A S NASLEVA+LRDDFRQ+P
Sbjct: 78 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
Query: 173 GNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAG 232
+V+VAVGEPAV+EC PPRGHPEP++SW+KDG+ L +++ RITIRGGKLM+++T KSDAG
Sbjct: 138 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 197
Query: 233 MYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWR 292
YVCV +NM GERES AE+ VLERPSF++RP N V D F CE +GDP P +RWR
Sbjct: 198 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 293 KEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQ 352
K+DGELP RYEIR DH+L I V+A D G+YTCVAEN VG+AEAS +L+V PP V +
Sbjct: 258 KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK 317
Query: 353 PQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNIT 412
P+DQ+ A G +V FQCE GNP PAIFW++EGSQ LLF Q Q + RFSVS G L IT
Sbjct: 318 PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 377
Query: 413 AVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPC 472
VQR D GYY+CQ ++VAGSI+ KA LE+ D PPVI QGP NQT+ + + L C
Sbjct: 378 NVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC 437
Query: 473 RVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATW 532
TG+P P++ W+KDG + D + K + NG L I + D G Y+C+A + +GEATW
Sbjct: 438 VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATW 497
Query: 533 SGWLKMRE-DWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVI 591
S +++++E V P PT+P+ P APS+P VT++++N++TL+W+PN +GA TSY+I
Sbjct: 498 SAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYII 557
Query: 592 EAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQD 651
EAFS A+G++W+TVA+ V+ ET + GL+PN IYLFLVRA A+G+S+PS +S+PV+TQD
Sbjct: 558 EAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQD 617
Query: 652 SSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAGP 711
P+ D + Q+ L + L P VL +++V WTVD Q +QG+++ +R +G
Sbjct: 618 VLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGA 677
Query: 712 EGG--SWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPS 769
G W + ++++P++ S V+ L G +IK + E GA+S EEAPS
Sbjct: 678 NHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPS 737
Query: 770 GPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGWARS 829
PPQGV V+ ++I VSW+PP QNG++ EY++WCLGNE+R+H+N++ G S
Sbjct: 738 APPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFS 797
Query: 830 AMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPD-LEPGLEVGAGLAVRLARVL 888
++ LVPG+ Y VAA+T AG GV S P +QL + + + P E LA +++ V+
Sbjct: 798 VVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSP--EDQVSLAQQISDVV 855
Query: 889 REPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTA------SFAYTPAVSFPHSEG 942
++PAF+AG GAAC +L+ LY RK+R L+ A SF +TP V++
Sbjct: 856 KQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGE 915
Query: 943 LSGASSRPPMGL----GPAPYSWLADSWPHPSRSPSAQEPRGSCCPS---NPDPDDRYYN 995
+ RP GL PA WLAD+WP+ + + + SCC + N D + Y+
Sbjct: 916 AVSSGGRP--GLLNISEPAAQPWLADTWPNTGNNHN--DCSISCCTAGNGNSDSNLTTYS 971
Query: 996 E-----AGISLYLAQTARGTAAPGEGPVYSTIDPAGE--ELQTFHG-----GFPQHPSGD 1043
A + L P E VY +D + + E++TF+ G +PSG
Sbjct: 972 RPADCIANYNNQLDNKQTNLMLP-ESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQ 1030
Query: 1044 LGPW--SQYAPPEWS------QGDSGAKG----GKVKLLGKPVQ-----MPSLNWP---- 1082
P+ +Q S GDSG K G+ K PVQ LN
Sbjct: 1031 PTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRAN 1090
Query: 1083 EALPPPPP---------------SCELSCLEGPEEELEGSSEPE-------EWCPPMPER 1120
+ +PP P S S G + +G+ P+ W +P
Sbjct: 1091 DTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPP 1150
Query: 1121 SHLTEPSSSG---------------GCLVTPSR-----------RETPSPTP-------- 1146
P S+ C V P+R + PTP
Sbjct: 1151 PAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASS 1210
Query: 1147 ----SYGQQSTATLTPSPPDPPQP-----PTDMPHLHQMP--RRVPLGPSSP 1187
SY QSTATLTPSP + QP P + H+ P RR P+ P P
Sbjct: 1211 PAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPP 1262
Score = 42.0 bits (97), Expect = 0.004
Identities = 61/223 (27%), Positives = 86/223 (38%), Gaps = 65/223 (29%)
Query: 1196 GIREARPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQGPRARFRKKPKA 1255
G++ AR A H S P P++ S + T P + + + +P
Sbjct: 1376 GLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAK----KLKHQPGH 1431
Query: 1256 LPYRRENSPGDLPPPPLPPPEEEASWA-----LELR--AAGSMSSLER--ERSGERKAV- 1305
L RRE DLPPPP+PPP ++ A LE+R + S++ +RS +RK
Sbjct: 1432 L--RRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSS 1489
Query: 1306 ----------QAVPL-----------------------AAQRVLHPD-----EEAWLPYS 1327
Q V + AA+R L P +E LPY
Sbjct: 1490 YKGREVLDGRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYC 1549
Query: 1328 RPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGRSRSRSQS 1370
RP+F T+ + SSSS SRG G SR R Q+
Sbjct: 1550 RPTF----------PTSNNPRDPSSSSSMSSRGSG-SRQREQA 1581
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 958 bits (2477), Expect = 0.0
Identities = 550/1251 (43%), Positives = 741/1251 (59%), Gaps = 124/1251 (9%)
Query: 54 GSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRA 113
GSR+ ED PRIVE P DL+VS+GEPATL C+AEGRP P IEWYK G RV T ++DPR+
Sbjct: 58 GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS 117
Query: 114 HRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPG 173
HR+LLPSG+LFF RIVHGR++RPDEGVY CVARNYLG A S NASLEVA+LRDDFRQ+P
Sbjct: 118 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 177
Query: 174 NVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGM 233
+V+VAVGEPAV+EC PPRGHPEP++SW+KDG+ L +++ RITIRGGKLM+++T KSDAG
Sbjct: 178 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 237
Query: 234 YVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRK 293
YVCV +NM GERES AE+ VLERPSF++RP N V D F CE +GDP P +RWRK
Sbjct: 238 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 297
Query: 294 EDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQP 353
+DGELP RYEIR DH+L I V+A D G+YTCVAEN VG+AEAS +L+V PP V +P
Sbjct: 298 DDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKP 357
Query: 354 QDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITA 413
+DQ+ A G +V FQCE GNP PAIFW++EGSQ LLF Q Q + RFSVS G L IT
Sbjct: 358 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 417
Query: 414 VQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCR 473
VQR D GYY+CQ ++VAGSI+ KA LE+ D PPVI QGP NQT+ + + L C
Sbjct: 418 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCV 477
Query: 474 VTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWS 533
TG+P P++ W+KDG + D + K + NG L I + D G Y+C+A + +GEATWS
Sbjct: 478 ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 537
Query: 534 GWLKMRE-DWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIE 592
+++++E V P PT+P+ P APS+P VT++++N++TL+W+PN +GA TSY+IE
Sbjct: 538 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 597
Query: 593 AFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDS 652
AFS A+G++W+TVA+ V+ ET + GL+PN IYLFLVRA A+G+S+PS +S+PV+TQD
Sbjct: 598 AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDV 657
Query: 653 SPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAGPE 712
P+ D + Q+ L + L P VL +++V WTVD Q +QG+++ +R +G
Sbjct: 658 LPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGAN 717
Query: 713 GG--SWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSG 770
G W + ++++P++ S V+ L G +IK + E GA+S EEAPS
Sbjct: 718 HGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSA 777
Query: 771 PPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGWARSA 830
PPQGV V+ ++I VSW+PP QNG++ EY++WCLGNE+R+H+N++ G S
Sbjct: 778 PPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSV 837
Query: 831 MLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPD-LEPGLEVGAGLAVRLARVLR 889
++ LVPG+ Y VAA+T AG GV S P +QL + + + P E LA +++ V++
Sbjct: 838 VIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSP--EDQVSLAQQISDVVK 895
Query: 890 EPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTA------SFAYTPAVSFPHSEGL 943
+PAF+AG GAAC +L+ LY RK+R L+ A SF +TP V++
Sbjct: 896 QPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEA 955
Query: 944 SGASSRPPMGL----GPAPYSWLADSWPHPSRSPSAQEPRGSCCPS---NPDPDDRYYNE 996
+ RP GL PA WLAD+WP+ + + + SCC + N D + Y+
Sbjct: 956 VSSGGRP--GLLNISEPAAQPWLADTWPNTGNNHN--DCSISCCTAGNGNSDSNLTTYSR 1011
Query: 997 -----AGISLYLAQTARGTAAPGEGPVYSTIDPAGE--ELQTFHG-----GFPQHPSGDL 1044
A + L P E VY +D + + E++TF+ G +PSG
Sbjct: 1012 PADCIANYNNQLDNKQTNLMLP-ESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQP 1070
Query: 1045 GPW--SQYAPPEWS------QGDSGAKG----GKVKLLGKPVQ-----MPSLNWP----E 1083
P+ +Q S GDSG K G+ K PVQ LN +
Sbjct: 1071 TPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRAND 1130
Query: 1084 ALPPPPP---------------SCELSCLEGPEEELEGSSEPE-------EWCPPMPERS 1121
+PP P S S G + +G+ P+ W +P
Sbjct: 1131 TVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP 1190
Query: 1122 HLTEPSSSG---------------GCLVTPSR-----------RETPSPTP--------- 1146
P S+ C V P+R + PTP
Sbjct: 1191 AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSP 1250
Query: 1147 ---SYGQQSTATLTPSPPDPPQP-----PTDMPHLHQMP--RRVPLGPSSP 1187
SY QSTATLTPSP + QP P + H+ P RR P+ P P
Sbjct: 1251 AAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPP 1301
Score = 42.0 bits (97), Expect = 0.004
Identities = 61/223 (27%), Positives = 86/223 (38%), Gaps = 65/223 (29%)
Query: 1196 GIREARPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQGPRARFRKKPKA 1255
G++ AR A H S P P++ S + T P + + + +P
Sbjct: 1415 GLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAK----KLKHQPGH 1470
Query: 1256 LPYRRENSPGDLPPPPLPPPEEEASWA-----LELR--AAGSMSSLER--ERSGERKAV- 1305
L RRE DLPPPP+PPP ++ A LE+R + S++ +RS +RK
Sbjct: 1471 L--RRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSS 1528
Query: 1306 ----------QAVPL-----------------------AAQRVLHPD-----EEAWLPYS 1327
Q V + AA+R L P +E LPY
Sbjct: 1529 YKGREVLDGRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYC 1588
Query: 1328 RPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGRSRSRSQS 1370
RP+F T+ + SSSS SRG G SR R Q+
Sbjct: 1589 RPTF----------PTSNNPRDPSSSSSMSSRGSG-SRQREQA 1620
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 956 bits (2470), Expect = 0.0
Identities = 551/1255 (43%), Positives = 743/1255 (59%), Gaps = 127/1255 (10%)
Query: 53 NGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPR 112
+GSR+ ED PRIVE P DL+VS+GEPATL C+AEGRP P IEWYK G RV T ++DPR
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 77
Query: 113 AHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSP 172
+HR+LLPSG+LFF RIVHGR++RPDEGVY CVARNYLG A S NASLEVA+LRDDFRQ+P
Sbjct: 78 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
Query: 173 GNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAG 232
+V+VAVGEPAV+EC PPRGHPEP++SW+KDG+ L +++ RITIRGGKLM+++T KSDAG
Sbjct: 138 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 197
Query: 233 MYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWR 292
YVCV +NM GERES AE+ VLERPSF++RP N V D F CE +GDP P +RWR
Sbjct: 198 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 293 KEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHV---PPQL 349
K+DGELP RYEIR DH+L I V+A D G+YTCVAEN VG+AEAS +L+V V PP
Sbjct: 258 KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
Query: 350 VTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQL 409
V +P+DQ+ A G +V FQCE GNP PAIFW++EGSQ LLF Q Q + RFSVS G L
Sbjct: 318 VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 410 NITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVW 469
IT VQR D GYY+CQ ++VAGSI+ KA LE+ D PPVI QGP NQT+ + +
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 437
Query: 470 LPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGE 529
L C TG+P P++ W+KDG + D + K + NG L I + D G Y+C+A + +GE
Sbjct: 438 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 497
Query: 530 ATWSGWLKMRE-DWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTS 588
ATWS +++++E V P PT+P+ P APS+P VT++++N++TL+W+PN +GA TS
Sbjct: 498 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS 557
Query: 589 YVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVR 648
Y+IEAFS A+G++W+TVA+ V+ ET + GL+PN IYLFLVRA A+G+S+PS +S+PV+
Sbjct: 558 YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 617
Query: 649 TQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRV 708
TQD P+ D + Q+ L + L P VL +++V WTVD Q +QG+++ +R
Sbjct: 618 TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP 677
Query: 709 AGPEGG--SWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEE 766
+G G W + ++++P++ S V+ L G +IK + E GA+S EE
Sbjct: 678 SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE 737
Query: 767 APSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGW 826
APS PPQGV V+ ++I VSW+PP QNG++ EY++WCLGNE+R+H+N++ G
Sbjct: 738 APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 797
Query: 827 ARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPD-LEPGLEVGAGLAVRLA 885
S ++ LVPG+ Y VAA+T AG GV S P +QL + + + P E LA +++
Sbjct: 798 TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSP--EDQVSLAQQIS 855
Query: 886 RVLREPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTA------SFAYTPAVSFPH 939
V+++PAF+AG GAAC +L+ LY RK+R L+ A SF +TP V++
Sbjct: 856 DVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQR 915
Query: 940 SEGLSGASSRPPMGL----GPAPYSWLADSWPHPSRSPSAQEPRGSCCPS---NPDPDDR 992
+ RP GL PA WLAD+WP+ + + + SCC + N D +
Sbjct: 916 GGEAVSSGGRP--GLLNISEPAAQPWLADTWPNTGNNHN--DCSISCCTAGNGNSDSNLT 971
Query: 993 YYNE-----AGISLYLAQTARGTAAPGEGPVYSTIDPAGE--ELQTFHG-----GFPQHP 1040
Y+ A + L P E VY +D + + E++TF+ G +P
Sbjct: 972 TYSRPADCIANYNNQLDNKQTNLMLP-ESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNP 1030
Query: 1041 SGDLGPW--SQYAPPEWS------QGDSGAKG----GKVKLLGKPVQ-----MPSLNWP- 1082
SG P+ +Q S GDSG K G+ K PVQ LN
Sbjct: 1031 SGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDY 1090
Query: 1083 ---EALPPPPP---------------SCELSCLEGPEEELEGSSEPE-------EWCPPM 1117
+ +PP P S S G + +G+ P+ W +
Sbjct: 1091 RANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLL 1150
Query: 1118 PERSHLTEPSSSG---------------GCLVTPSR-----------RETPSPTP----- 1146
P P S+ C V P+R + PTP
Sbjct: 1151 PPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARTYLQQDELEEEEDERGPTPPVRGA 1210
Query: 1147 -------SYGQQSTATLTPSPPDPPQP-----PTDMPHLHQMP--RRVPLGPSSP 1187
SY QSTATLTPSP + QP P + H+ P RR P+ P P
Sbjct: 1211 ASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPP 1265
Score = 42.0 bits (97), Expect = 0.004
Identities = 61/223 (27%), Positives = 86/223 (38%), Gaps = 65/223 (29%)
Query: 1196 GIREARPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQGPRARFRKKPKA 1255
G++ AR A H S P P++ S + T P + + + +P
Sbjct: 1379 GLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAK----KLKHQPGH 1434
Query: 1256 LPYRRENSPGDLPPPPLPPPEEEASWA-----LELR--AAGSMSSLER--ERSGERKAV- 1305
L RRE DLPPPP+PPP ++ A LE+R + S++ +RS +RK
Sbjct: 1435 L--RRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSS 1492
Query: 1306 ----------QAVPL-----------------------AAQRVLHPD-----EEAWLPYS 1327
Q V + AA+R L P +E LPY
Sbjct: 1493 YKGREVLGGRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYC 1552
Query: 1328 RPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGRSRSRSQS 1370
RP+F T+ + SSSS SRG G SR R Q+
Sbjct: 1553 RPTF----------PTSNNPRDPSSSSSMSSRGSG-SRQREQA 1584
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 950 bits (2455), Expect = 0.0
Identities = 548/1249 (43%), Positives = 741/1249 (59%), Gaps = 124/1249 (9%)
Query: 53 NGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPR 112
+GSR+ ED PRIVE P DL+VS+GEPATL C+AEGRP P IEWYK G RV T ++DPR
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 77
Query: 113 AHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSP 172
+HR+LLPSG+LFF RIVHGR++RPDEGVY CVARNYLG A S NASLEVA+LRDDFRQ+P
Sbjct: 78 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
Query: 173 GNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAG 232
+V+VAVGEPAV+EC PPRGHPEP++SW+KDG+ L +++ RITIRGGKLM+++T KSDAG
Sbjct: 138 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 197
Query: 233 MYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWR 292
YVCV +NM GERES AE+ VLERPSF++RP N V D F CE +GDP P +RWR
Sbjct: 198 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 293 KEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHV---PPQL 349
K+DGELP RYEIR DH+L I V+A D G+YTCVAEN VG+AEAS +L+V V PP
Sbjct: 258 KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
Query: 350 VTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQL 409
V +P+DQ+ A G +V FQCE GNP PAIFW++EGSQ LLF Q Q + RFSVS G L
Sbjct: 318 VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 410 NITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVW 469
IT VQR D GYY+CQ ++VAGSI+ KA LE+ D PPVI QGP NQT+ + +
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 437
Query: 470 LPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGE 529
L C TG+P P++ W+KDG + D + K + NG L I + D G Y+C+A + +GE
Sbjct: 438 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 497
Query: 530 ATWSGWLKMRE-DWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTS 588
ATWS +++++E V P PT+P+ P APS+P VT++++N++TL+W+PN +GA TS
Sbjct: 498 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS 557
Query: 589 YVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVR 648
Y+IEAFS A+G++W+TVA+ V+ ET + GL+PN IYLFLVRA A+G+S+PS +S+PV+
Sbjct: 558 YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 617
Query: 649 TQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRV 708
TQD P+ D + Q+ L + L P VL +++V WTVD Q +QG+++ +R
Sbjct: 618 TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP 677
Query: 709 AGPEGG--SWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEE 766
+G G W + ++++P++ S V+ L G +IK + E GA+S EE
Sbjct: 678 SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE 737
Query: 767 APSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGW 826
APS PPQGV V+ ++I VSW+PP QNG++ EY++WCLGNE+R+H+N++ G
Sbjct: 738 APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 797
Query: 827 ARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPD-LEPGLEVGAGLAVRLA 885
S ++ LVPG+ Y VAA+T AG GV S P +QL + + + P E LA +++
Sbjct: 798 TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSP--EDQVSLAQQIS 855
Query: 886 RVLREPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTASFAYTPAVSFPHSEGLSG 945
V+++PAF+AG GAAC +L+ LY RK+R L T+++A V++
Sbjct: 856 DVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGL---TSTYAGIRKVTYQRGGEAVS 912
Query: 946 ASSRPPMGL----GPAPYSWLADSWPHPSRSPSAQEPRGSCCPS---NPDPDDRYYNE-- 996
+ RP GL PA WLAD+WP+ + + + SCC + N D + Y+
Sbjct: 913 SGGRP--GLLNISEPAAQPWLADTWPNTGNNHN--DCSISCCTAGNGNSDSNLTTYSRPA 968
Query: 997 ---AGISLYLAQTARGTAAPGEGPVYSTIDPAGE--ELQTFHG-----GFPQHPSGDLGP 1046
A + L P E VY +D + + E++TF+ G +PSG P
Sbjct: 969 DCIANYNNQLDNKQTNLMLP-ESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTP 1027
Query: 1047 W--SQYAPPEWS------QGDSGAKG----GKVKLLGKPVQ-----MPSLNWP----EAL 1085
+ +Q S GDSG K G+ K PVQ LN + +
Sbjct: 1028 YATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTV 1087
Query: 1086 PPPPP---------------SCELSCLEGPEEELEGSSEPE-------EWCPPMPERSHL 1123
PP P S S G + +G+ P+ W +P
Sbjct: 1088 PPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAH 1147
Query: 1124 TEPSSSG---------------GCLVTPSR-----------RETPSPTP----------- 1146
P S+ C V P+R + PTP
Sbjct: 1148 PPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAA 1207
Query: 1147 -SYGQQSTATLTPSPPDPPQP-----PTDMPHLHQMP--RRVPLGPSSP 1187
SY QSTATLTPSP + QP P + H+ P RR P+ P P
Sbjct: 1208 VSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPP 1256
Score = 42.0 bits (97), Expect = 0.004
Identities = 61/223 (27%), Positives = 86/223 (38%), Gaps = 65/223 (29%)
Query: 1196 GIREARPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQGPRARFRKKPKA 1255
G++ AR A H S P P++ S + T P + + + +P
Sbjct: 1370 GLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAK----KLKHQPGH 1425
Query: 1256 LPYRRENSPGDLPPPPLPPPEEEASWA-----LELR--AAGSMSSLER--ERSGERKAV- 1305
L RRE DLPPPP+PPP ++ A LE+R + S++ +RS +RK
Sbjct: 1426 L--RRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSS 1483
Query: 1306 ----------QAVPL-----------------------AAQRVLHPD-----EEAWLPYS 1327
Q V + AA+R L P +E LPY
Sbjct: 1484 YKGREVLDGRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYC 1543
Query: 1328 RPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGRSRSRSQS 1370
RP+F T+ + SSSS SRG G SR R Q+
Sbjct: 1544 RPTF----------PTSNNPRDPSSSSSMSSRGSG-SRQREQA 1575
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 228 bits (582), Expect = 2e-59
Identities = 217/840 (25%), Positives = 357/840 (42%), Gaps = 80/840 (9%)
Query: 60 EDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDP-RAHRLLL 118
ED PRIV + +V+ GE +L C A+G P P + W + + VR+ R ++ +
Sbjct: 464 EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI--VRDGSHRTNQYTM 521
Query: 119 PSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVA 178
G V G + R D GVY C ARN +G+A + + V ++ N+
Sbjct: 522 SDGTTISHMNVTGPQIR-DGGVYRCTARNLVGSAEYQ---ARINVRGPPSIRAMRNITAV 577
Query: 179 VGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKS-DAGMYVCV 237
G ++ C G+P S+ W KD L + ++ G L ++ K D G Y+C
Sbjct: 578 AGRDTLINC-RVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLC- 635
Query: 238 ASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFL-CEVK-GDPPPRLRWRKED 295
S + + S + V V + L +P + + ++ C V GD P R+ WRK+
Sbjct: 636 -SVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDG 694
Query: 296 GELPTGR-YEIRSDH---SLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVT 351
+ +G I S SL I VS + G YTC+A N+ L V VPP+ V
Sbjct: 695 QVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVV 754
Query: 352 QPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNI 411
QP +Q G++ C G PPP + W+ + TGR + P L I
Sbjct: 755 QPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLI 814
Query: 412 TAVQRGDAGYYVCQAVSVAGSILAKAL-LEIKGASLDGLPPVILQGPANQTLVLGSSVWL 470
V D GYY+CQA + G+ ++K++ L +K +P +I P + G + L
Sbjct: 815 RHVLEEDIGYYLCQASNGVGTDISKSMFLTVK------IPAMITSHPNTTIAIKGHAKEL 868
Query: 471 PCRVTGNPQPSVRWKKDGQWLQGDDLQ---FKTMANG-----TLYIANVQEMDMGFYSCV 522
C G +RW+K + D + T NG TL + D F+SC
Sbjct: 869 NCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCH 928
Query: 523 AKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQT 582
A +S G ED G+ EP PP + + E+ S+ L W
Sbjct: 929 AINSYG-----------EDRGLIQLTVQEPPDPP----ELEIREVKARSMNLRWTQRFDG 973
Query: 583 GAAVTSYVIEAFSPAAGNTWRTVADGVQ--LETHTVSGLQPNTIYLFLVRAVGAWGLSEP 640
+ +T + IE + + ++ + + + L P ++Y + + G SEP
Sbjct: 974 NSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEP 1033
Query: 641 SPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTV---DGPVQ 697
S + T++++P P D V LQ P+ +++QV+W +
Sbjct: 1034 SK-ELTISTEEAAPDGPPMD------------VTLQ-PVT--SQSIQVTWKAPKKELQNG 1077
Query: 698 LVQGFRVSWRVAGP-EGGSWTMLDLQSPSQQST-VLRGLPPGTQIQIKVQAQGQEGLGAE 755
+++G+++ +R P G ++++++++ L L Q + VQA + G G
Sbjct: 1078 VIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPS 1137
Query: 756 SLSVTRSIPEEAPSGPPQGV-AVALGGDGNSSITVSWEPPLPSQQNGVITEYQI--WCLG 812
S + + E+ PS PP+ V A+++ D +SW P S NGV+ Y++ W L
Sbjct: 1138 SSEINATTLEDVPSQPPENVRALSITSD---VAVISWSEPPRSTLNGVLKGYRVIFWSLY 1194
Query: 813 NESRFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQ----LPSPP 868
+ + ++ LRG+ Y V A T AG GV S+ + +Q +P PP
Sbjct: 1195 VDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPP 1254
Score = 177 bits (449), Expect = 6e-44
Identities = 223/864 (25%), Positives = 358/864 (41%), Gaps = 128/864 (14%)
Query: 57 VGPEDAMPRI-VEQPPDLLVSR------GEPATLPCRAEGRPRPNIEWYKNGARVATVRE 109
VG + RI V PP + R G + CR G P +I+WYK+ +
Sbjct: 551 VGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLL----- 605
Query: 110 DPRAHR-LLLPSGALFFPRIVHGRRARPDEGVYTC--VARNYLGAAASRNASLEVAVLRD 166
P HR ++ +G L + G DEG Y C + + L + S + +++V L
Sbjct: 606 -PDNHRQVVFENGTLKLTDVQKGM----DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQ 660
Query: 167 DFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHT 226
F P ++ G+ + CV G ++WRKDG + G +TI + M S
Sbjct: 661 PFEFPPASI----GQLLYIPCVVSSGDMPIRITWRKDGQVIISGSG-VTIESKEFMSSLQ 715
Query: 227 LKSDA----GMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVK 282
+ S + G Y C+ASN A S +++V P F+ +P NQ + C V
Sbjct: 716 ISSVSLKHNGNYTCIASNAAAT-VSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVD 774
Query: 283 GDPPPRLRWRKEDGE--------LP-TGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVG 333
G PPP++ W+ G +P TGR +I + SL I HV ED G Y C A N VG
Sbjct: 775 GYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVG 834
Query: 334 R-AEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPS 392
S L+V +P + + P +A G + C +G P I W+K ++ P
Sbjct: 835 TDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEK--GDTVIDPD 892
Query: 393 QSLQPTGRFSVSPRGQ-------LNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGAS 445
+ + R++++ + L + RGD+ ++ C A++ G
Sbjct: 893 RVM----RYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDR----------- 937
Query: 446 LDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKK--DGQWL-QGDDLQFKTMA 502
GL + +Q P + L R ++RW + DG + G D+++K +
Sbjct: 938 --GLIQLTVQEPPDPPE-------LEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKS 988
Query: 503 NG------------TLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPT 550
+ T+ AN+ ++ + S + G + ++ +S T
Sbjct: 989 DSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKI---GRSEPSKELTIS----T 1041
Query: 551 EPSSPPGAPSQPVVTEITKNSITLTWKPNPQT--GAAVTSYVI--EAFSPAAGNTWRTV- 605
E ++P G P + +T SI +TWK + + Y I SP + + V
Sbjct: 1042 EEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVE 1101
Query: 606 --ADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWR 663
A G E +T+ L+ Y +V+A G PS T + PS+P E+ R
Sbjct: 1102 MKATG-DSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSEINATTLEDVPSQPPENV-R 1158
Query: 664 GQQGLAEVAV-RLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVS-WRVAGPEGGSWTMLDL 721
++VAV EP PR+ T++G +++G+RV W + G W +
Sbjct: 1159 ALSITSDVAVISWSEP----PRS-----TLNG---VLKGYRVIFWSLY--VDGEWGEMQN 1204
Query: 722 QSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGG 781
+ +++ LRG+ T ++V A Q G G S + E+ P GPP G+
Sbjct: 1205 ITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP-GPPAGIKAV--P 1261
Query: 782 DGNSSITVSWEPPLPSQQNGVITEYQIWCL--GNESRFHLNRSAAGWARSAMLRGLVPGL 839
SS+ VSW PP ++ NGVI +Y I+C G+ + + L G
Sbjct: 1262 SSASSVVVSWLPP--TKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQ 1319
Query: 840 LYRTLVAAATSAGVGVPSAPVLVQ 863
Y VAA TSAG G S V ++
Sbjct: 1320 QYLLWVAAVTSAGRGNSSEKVTIE 1343
Score = 135 bits (339), Expect = 4e-31
Identities = 136/531 (25%), Positives = 219/531 (41%), Gaps = 67/531 (12%)
Query: 53 NGSRVG---PEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVRE 109
NG+R+ P +++P I++ V G LPC A G P P I W K+G
Sbjct: 272 NGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP------ 325
Query: 110 DPRAHRLLLPSGALFFPRIVH---GRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRD 166
LP+ + + RI D G Y C N G+A + + + L
Sbjct: 326 --------LPADSRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLH- 376
Query: 167 DFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRG---GKLMM 223
+P + +G +L C G PE ++ W ++ + +E I+IRG L++
Sbjct: 377 -VTLTPKKLKTGIGSTVILSCA-LTGSPEFTIRWYRNTELVLPDEA-ISIRGLSNETLLI 433
Query: 224 SHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKG 283
+ KS +G Y C A+ A + A + P + +VV + +C KG
Sbjct: 434 TSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKG 493
Query: 284 DPPPRLRWRKE------DGELPTGRYEIRSDHSLWIGHVSA-----EDEGTYTCVAENSV 332
PPP + W + DG T +Y + + I H++ D G Y C A N V
Sbjct: 494 APPPTVTWALDDEPIVRDGSHRTNQYTMSDGTT--ISHMNVTGPQIRDGGVYRCTARNLV 551
Query: 333 GRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPS 392
G AE ++V PP + ++ A G C G P +I W K+ LL P
Sbjct: 552 GSAEYQARINVRGPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKD---ALLLPD 607
Query: 393 QSLQPTGRFSVSPRGQLNITAVQRG-DAGYYVCQAVSVAGSILAKALLEI-KGASLDGLP 450
Q V G L +T VQ+G D G Y+C S+L + L I + +
Sbjct: 608 NHRQ-----VVFENGTLKLTDVQKGMDEGEYLC-------SVLIQPQLSISQSVHVAVKV 655
Query: 451 PVILQGPANQTLVLGSSVWLPCRVTGNPQP-SVRWKKDGQWL---QGDDLQFKTMANGTL 506
P ++Q +G +++PC V+ P + W+KDGQ + G ++ K + +L
Sbjct: 656 PPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMS-SL 714
Query: 507 YIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPG 557
I++V G Y+C+A ++ + L +R V P +P++ G
Sbjct: 715 QISSVSLKHNGNYTCIASNAAATVSRERQLIVR----VPPRFVVQPNNQDG 761
Score = 133 bits (335), Expect = 1e-30
Identities = 130/478 (27%), Positives = 193/478 (40%), Gaps = 40/478 (8%)
Query: 83 LPCRAEGRPRPNIEWY-KNGARVATVREDPRAHR----LLLPSGALFFPRIVHGRRARPD 137
+PC A G P + WY G + V H L P F +H
Sbjct: 105 VPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIH------- 157
Query: 138 EGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPE-- 195
+ Y C A N G S N ++ AV R+ + + G AV +C+ P E
Sbjct: 158 DNDYFCTAENAAGKIRSPNIRVK-AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYV 216
Query: 196 PSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDA-GMYVCVASNM-AGE-RESAAAEV 252
VSW KD + E G L +S K DA Y C+ + +GE R+S A +
Sbjct: 217 SVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARL 276
Query: 253 MVLER----PSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSD 308
V + P+ L +Q V A V C G P P +RW K+ LP +
Sbjct: 277 SVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRI 336
Query: 309 HSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQC 368
L I + ED GTY C N+ G AEA+G L V P + P+ G +V C
Sbjct: 337 TGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSC 396
Query: 369 ETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVS 428
G+P I W + VL P +++ G + + L IT+ Q+ +G Y C A
Sbjct: 397 ALTGSPEFTIRWYRNTELVL--PDEAISIRGLSNET----LLITSAQKSHSGAYQCFATR 450
Query: 429 VAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDG 488
A + A++ ++ DG P ++ + + + G L C G P P+V W D
Sbjct: 451 KAQTAQDFAIIALE----DGTPRIV-SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDD 505
Query: 489 QWLQGDD---LQFKTMANGT----LYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMR 539
+ + D TM++GT + + Q D G Y C A++ G A + + +R
Sbjct: 506 EPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVR 563
Score = 65.5 bits (158), Expect = 3e-10
Identities = 89/387 (22%), Positives = 147/387 (37%), Gaps = 51/387 (13%)
Query: 411 ITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWL 470
I + RG AV+ AG + + I+ A P I+ T V L
Sbjct: 1312 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGK--APAKIISFGGTVTTPWMKDVRL 1369
Query: 471 PCRVTGNPQPSVRWKKDGQ------WLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAK 524
PC G+P P+V+W KD + + G L NGTL + V+ D G+Y+C A
Sbjct: 1370 PCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRL---IHTNGTLLLRAVKAEDSGYYTCTAT 1426
Query: 525 SSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGA 584
++ G T L ++ V PD P + V++ + +SITLTW P G+
Sbjct: 1427 NTGGFDTIIVNLLVQ----VPPDQP-----------RLTVSKTSASSITLTWIPGDNGGS 1471
Query: 585 AVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVS 644
++ +V++ +S W+ V + + L+ T Y + A + G S +
Sbjct: 1472 SIRGFVLQ-YSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEII 1530
Query: 645 EPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDG-PV-QLVQGF 702
E +T PS + + LQ W G P+ +V +
Sbjct: 1531 E-AKTHGREPSFSKDQHLFTHINSTHARLNLQ------------GWNNGGCPITAIVLEY 1577
Query: 703 RVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRS 762
R G+W L++ S L L T +++++A G G E+ +
Sbjct: 1578 RPK--------GTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCGNETAQFA-T 1628
Query: 763 IPEEAPSGPPQGVAVALGGDGNSSITV 789
+ + + PP A G D T+
Sbjct: 1629 LDYDGSTIPPIKSAQGEGDDVKKLFTI 1655
Score = 48.9 bits (115), Expect = 3e-05
Identities = 29/74 (39%), Positives = 38/74 (51%), Gaps = 5/74 (6%)
Query: 279 CEVKGDPPPRLRWRK--EDGELPT---GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVG 333
C GDP P ++W K ED +P G I ++ +L + V AED G YTC A N+ G
Sbjct: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
Query: 334 RAEASGSLSVHVPP 347
+L V VPP
Sbjct: 1431 FDTIIVNLLVQVPP 1444
Score = 46.6 bits (109), Expect = 2e-04
Identities = 34/153 (22%), Positives = 64/153 (41%), Gaps = 11/153 (7%)
Query: 296 GELPTGRYEIRSDHSLW-IGHVSAEDEGTYTCVAENSVGRAEASGSLSVH----VPPQLV 350
G+ YE + + I H++ + A S GR +S +++ P +++
Sbjct: 1294 GQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKII 1353
Query: 351 TQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLN 410
+ + V C + G+P PA+ W K+ + S G + G L
Sbjct: 1354 SFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMD----GHRLIHTNGTLL 1409
Query: 411 ITAVQRGDAGYYVCQAVSVAG--SILAKALLEI 441
+ AV+ D+GYY C A + G +I+ L+++
Sbjct: 1410 LRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQV 1442
Score = 36.6 bits (83), Expect = 0.17
Identities = 20/65 (30%), Positives = 30/65 (46%), Gaps = 6/65 (9%)
Query: 83 LPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYT 142
LPC + G P P ++W K+ + + + HRL+ +G L + D G YT
Sbjct: 1369 LPCNSVGDPAPAVKWTKD-SEDSAIPVSMDGHRLIHTNGTLLLRAV-----KAEDSGYYT 1422
Query: 143 CVARN 147
C A N
Sbjct: 1423 CTATN 1427
Score = 35.0 bits (79), Expect = 0.50
Identities = 34/154 (22%), Positives = 61/154 (39%), Gaps = 8/154 (5%)
Query: 192 GHPEPSVSWRKDGAR----LKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERES 247
G P P+V W KD + + R+ G L++ D+G Y C A+N G ++
Sbjct: 1375 GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG-FDT 1433
Query: 248 AAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPR---LRWRKEDGELPTGRYE 304
++V P R V++ + +T++ G R L++ ++ E +
Sbjct: 1434 IIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFI 1493
Query: 305 IRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEAS 338
S+ S + + A+NSVG S
Sbjct: 1494 SSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRIS 1527
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 220 bits (560), Expect = 8e-57
Identities = 160/524 (30%), Positives = 247/524 (47%), Gaps = 59/524 (11%)
Query: 32 GFNSSLAALNHTLLPPGDPSLNGSRVGPEDAMPRI-----------------VEQPP--- 71
G N + + NH +LP G L SR EDA + V+ PP
Sbjct: 4025 GINVNTSGRNHAVLPSG--GLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVIS 4082
Query: 72 ----DLLVSRGEPATLPCRAEGRPRPNIEWYKNG-ARVATVREDPRAHRLLLPSGALFFP 126
+ +++ +P TL C A+G P P+I W+K+G A V ++R+ +L SG+L
Sbjct: 4083 PHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQR------VLSSGSLQIA 4136
Query: 127 RIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLE 186
+ G D G YTC+A N G++ S + L V V R + G+ V A+L
Sbjct: 4137 FVQPG-----DAGHYTCMAANVAGSS-STSTKLTVHV-PPRIRSTEGHYTVNENSQAILP 4189
Query: 187 CVPPRGHPEPSVSWRKDGARLKEEEGRITIRG-GKLMMSHTLKSDAGMYVCVASNMAGER 245
CV G P P+++W+KD L G+ T G+L++ + + D+G Y CVA+N AGE
Sbjct: 4190 CVAD-GIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGE- 4247
Query: 246 ESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEI 305
++ + V P+F P + + + C+ G P P+L W + +P +
Sbjct: 4248 DTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSV 4307
Query: 306 RSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQ-PQDQMAAPGESV 364
L I VS ED GTY C AENSVG +A G + V PP P + + G +
Sbjct: 4308 NGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNA 4367
Query: 365 AFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVC 424
CE KG+P P I W ++G + + S ++ G S++ G +N DAG Y C
Sbjct: 4368 ILNCEVKGDPTPTIQWNRKGVDIEI--SHRIRQLGNGSLAIYGTVN------EDAGDYTC 4419
Query: 425 QAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRW 484
A + AG + L ++ PP+I P + G + L C+ TG PQP++ W
Sbjct: 4420 VATNEAGVVERSMSLTLQS------PPIITLEPVETVINAGGKIILNCQATGEPQPTITW 4473
Query: 485 KKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTG 528
+ G + DD + ++N +LYIA+ Q+ D + CVA++ G
Sbjct: 4474 SRQGHSISWDD-RVNVLSNNSLYIADAQKEDTSEFECVARNLMG 4516
Score = 210 bits (535), Expect = 7e-54
Identities = 151/471 (32%), Positives = 208/471 (44%), Gaps = 28/471 (5%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
P I P ++ V TL C A G P+P+I W KNG + V ++ ++RLL +
Sbjct: 3804 PSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNG-HLLNVDQNQNSYRLLSSGSLV 3862
Query: 124 FFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPA 183
V D Y C N G R L V V P + +V PA
Sbjct: 3863 IISPSVD------DTATYECTVTNGAGDD-KRTVDLTVQV-PPSIADEPTDFLVTKHAPA 3914
Query: 184 VLECVPPRGHPEPSVSWRKDGARLKEE-EGRITIRGGKLMMSHTLKSDAGMYVCVASNMA 242
V+ C G P PS+ W K+G RL +G + G + + T + AG Y CVA N A
Sbjct: 3915 VITCTAS-GVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAA 3973
Query: 243 GERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTG- 301
G + V E P +P V+ + P+ CE G P P + W+KE + T
Sbjct: 3974 GSAHRHVT-LHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSG 4032
Query: 302 -RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAP 360
+ + L I ED GTY CVA+N G A L+V VPP + ++ + A
Sbjct: 4033 RNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAV 4092
Query: 361 GESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAG 420
+ + CE G PPP I W K+G ++ +S+ R V G L I VQ GDAG
Sbjct: 4093 DKPITLSCEADGLPPPDITWHKDGRAIV----ESI----RQRVLSSGSLQIAFVQPGDAG 4144
Query: 421 YYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQP 480
+Y C A +VAGS L + +PP I + T+ S LPC G P P
Sbjct: 4145 HYTCMAANVAGSSSTSTKLTVH------VPPRIRSTEGHYTVNENSQAILPCVADGIPTP 4198
Query: 481 SVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEAT 531
++ WKKD L ++ G L + NV D GFY+CVA ++ GE T
Sbjct: 4199 AINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDT 4249
Score = 203 bits (517), Expect = 8e-52
Identities = 151/477 (31%), Positives = 215/477 (45%), Gaps = 36/477 (7%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
P I P L++ + L C AEG P P I W K+GA +A A +L +G L
Sbjct: 3713 PNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLA----GNHARYSILENGFL 3768
Query: 124 FFPRIVHGRRAR-PDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEP 182
H + A D G Y C+A N G R L+V V P N+ V V
Sbjct: 3769 ------HIQSAHVTDTGRYLCMATNAAGTDR-RRIDLQVHV-PPSIAPGPTNMTVIVNVQ 3820
Query: 183 AVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIR---GGKLMMSHTLKSDAGMYVCVAS 239
L C G P+PS++WRK+G L ++ + + R G L++ D Y C +
Sbjct: 3821 TTLAC-EATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVT 3879
Query: 240 NMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL- 298
N AG+ + ++ V PS P + +V AP C G P P + W K L
Sbjct: 3880 NGAGD-DKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLL 3938
Query: 299 PTGR-YEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQM 357
P G Y I S ++ I G YTCVA N+ G A +L VH PP + QP +
Sbjct: 3939 PRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELH 3998
Query: 358 AAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGR-FSVSPRGQLNITAVQR 416
+ CE G P P I WQKEG V +GR +V P G L I+ R
Sbjct: 3999 VILNNPILLPCEATGTPSPFITWQKEGINV--------NTSGRNHAVLPSGGLQISRAVR 4050
Query: 417 GDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTG 476
DAG Y+C A + AG+ L K L ++ +PPVI + + + L C G
Sbjct: 4051 EDAGTYMCVAQNPAGTALGKIKLNVQ------VPPVISPHLKEYVIAVDKPITLSCEADG 4104
Query: 477 NPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWS 533
P P + W KDG+ + + ++ + +++G+L IA VQ D G Y+C+A + G ++ S
Sbjct: 4105 LPPPDITWHKDGRAIV-ESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTS 4160
Score = 201 bits (512), Expect = 3e-51
Identities = 150/501 (29%), Positives = 231/501 (46%), Gaps = 40/501 (7%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
P I ++P D LV++ PA + C A G P P+I W KNG R+ + R +L SGA+
Sbjct: 3897 PSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYR----ILSSGAI 3952
Query: 124 --FFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGE 181
++ H R YTCVARN G+A R+ +L V + P + V +
Sbjct: 3953 EILATQLNHAGR-------YTCVARNAAGSA-HRHVTLHVHE-PPVIQPQPSELHVILNN 4003
Query: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEE-EGRITIRGGKLMMSHTLKSDAGMYVCVASN 240
P +L C G P P ++W+K+G + + G L +S ++ DAG Y+CVA N
Sbjct: 4004 PILLPC-EATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQN 4062
Query: 241 MAGERESAAAEVMV-LERPSFLRRPVNQVVLA-DAPVTFLCEVKGDPPPRLRWRKEDGEL 298
AG +A ++ + ++ P + + + V+A D P+T CE G PPP + W K+ +
Sbjct: 4063 PAG---TALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAI 4119
Query: 299 PTG-RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQM 357
R + S SL I V D G YTC+A N G + S L+VHVPP++ +
Sbjct: 4120 VESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYT 4179
Query: 358 AAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRG 417
C G P PAI W+K+ VLL G+++ P G+L + V
Sbjct: 4180 VNENSQAILPCVADGIPTPAINWKKDN--VLL-----ANLLGKYTAEPYGELILENVVLE 4232
Query: 418 DAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGN 477
D+G+Y C A + AG L + + P + P + +L G + L C+ TG
Sbjct: 4233 DSGFYTCVANNAAGEDTHTVSLTVH------VLPTFTELPGDVSLNKGEQLRLSCKATGI 4286
Query: 478 PQPSVRWKKDGQWLQGDDLQFKTM-ANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWL 536
P P + W + + F ++ + L I V + D G Y C A++S G G++
Sbjct: 4287 PLPKLTWTFNNNIIPA---HFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFV 4343
Query: 537 KMREDWGVSPDPPTEPSSPPG 557
++E D P+ P G
Sbjct: 4344 YVKEPPVFKGDYPSNWIEPLG 4364
Score = 190 bits (482), Expect = 9e-48
Identities = 148/507 (29%), Positives = 224/507 (44%), Gaps = 44/507 (8%)
Query: 83 LPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYT 142
+ CRA G P P I W KNG + +H LL +G + RIV + + D VYT
Sbjct: 3362 IECRATGTPPPQINWLKNGLPLPL-----SSHIRLLAAGQVI--RIVRAQVS--DVAVYT 3412
Query: 143 CVARNYLGAAASRNASLEV-AVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWR 201
CVA N G +++ +L+V A D + V G + C+ G P PS++W
Sbjct: 3413 CVASNRAGVD-NKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITD-GTPAPSMAWL 3470
Query: 202 KDGARLK-EEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSF 260
+DG L + ++ G L + D+G Y C+ASN AGE S + VLE P
Sbjct: 3471 RDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGE-VSKHFILKVLEPPHI 3529
Query: 261 LRRPVNQV--VLADAPVTFLCEVKGDPPPRLRWRKEDGELP-TGRYE-IRSDHSLWIGHV 316
++ V+ + P+ C G P P++ W K+ LP T + + + L I
Sbjct: 3530 NGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTA 3589
Query: 317 SAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLV--TQPQDQMAAPGESVAFQCETKGNP 374
ED G YTC+A + G + + VHVPP + +P+D V +C++ P
Sbjct: 3590 QVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVP 3649
Query: 375 PPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSIL 434
PP I W + G ++ P + GR+ L I GD Y C A ++AG
Sbjct: 3650 PPVITWLRNGERLQATPRVRILSGGRY-------LQINNADLGDTANYTCVASNIAGKTT 3702
Query: 435 AKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGD 494
+ +L + +PP I GP + ++L S L C G P P + W+KDG L G+
Sbjct: 3703 REFILTVN------VPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGN 3756
Query: 495 DLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSS 554
++ + NG L+I + D G Y C+A ++ G + R D V PS
Sbjct: 3757 HARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTD------RRRIDLQVH----VPPSI 3806
Query: 555 PPGAPSQPVVTEI-TKNSITLTWKPNP 580
PG + V+ + T + T P P
Sbjct: 3807 APGPTNMTVIVNVQTTLACEATGIPKP 3833
Score = 186 bits (472), Expect = 1e-46
Identities = 153/489 (31%), Positives = 210/489 (42%), Gaps = 57/489 (11%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRA-EGRPRPNIEWYKNGARVA-----TVREDPRAHRLL 117
P I P V G+ TLPC G P P W KN A + TVR D
Sbjct: 890 PLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSD------- 942
Query: 118 LPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVV 177
G+L R+ D G YTCVA N G ++ S+ V VL + +
Sbjct: 943 ---GSLHIERV-----QLQDGGEYTCVASNVAGTN-NKTTSVVVHVL-PTIQHGQQILST 992
Query: 178 AVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRG-GKLMMSHTLKSDAGMYVC 236
G P L C G+P+PSV W K G + + + G L + ++G YVC
Sbjct: 993 IEGIPVTLPC-KASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVC 1051
Query: 237 VASNMAGERESAAAEVMVLERPSFLR--------RPVNQVVLADAPVTFLCEVKGDPPPR 288
A+N AG + ++ V RP +PV VLA VT CEVK PPP
Sbjct: 1052 TATNTAGYAKRKV-QLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI 1110
Query: 289 LRWRKEDGELP--TGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVP 346
+ W KE + + R+ S+ I D G Y CVA N G + L+VHVP
Sbjct: 1111 ITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVP 1170
Query: 347 PQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVS-P 405
P++ P+ G+ V C +G P P I W K GS +L+ G VS P
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLV--------DGEHHVSNP 1222
Query: 406 RGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVI--LQGPANQTL- 462
G L+I DAG Y C A ++AG+ + L ++ PP + L+ P N T
Sbjct: 1223 DGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQE------PPTVEDLEPPYNTTFQ 1276
Query: 463 --VLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGT-LYIANVQEMDMGFY 519
V + PC G P+P+++W +G+ L G + + +GT L IA+V D G Y
Sbjct: 1277 ERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEY 1336
Query: 520 SCVAKSSTG 528
CVA + G
Sbjct: 1337 ICVAVNEAG 1345
Score = 179 bits (454), Expect = 2e-44
Identities = 138/486 (28%), Positives = 209/486 (43%), Gaps = 45/486 (9%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
P+++ +LLV+ G+ + C+ G P P ++W+K + R L+ L
Sbjct: 702 PKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLEL-------RPSTFLIIDPLL 754
Query: 124 FFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPA 183
+I + D G YTCVA N G A + +L+V F Q P +V + +G
Sbjct: 755 GLLKIQETQDL--DAGDYTCVAINEAGRATGK-ITLDVGS-PPVFIQEPADVSMEIGSNV 810
Query: 184 VLECVPPRGHPEPSVSWRK-DGARLKEEEGRIT----IRGGKLMMSHTLKSDAGMYVCVA 238
L C +G+PEP++ WR+ D + ++ +R G L + + SD G Y+C A
Sbjct: 811 TLPCYV-QGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEA 869
Query: 239 SNMAGERES-AAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEV-KGDPPPRLRWRKEDG 296
N G+ +S V L P P V+ +T C + G+P P RW K
Sbjct: 870 ENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSA 929
Query: 297 ELPTGRY-EIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQD 355
L Y +RSD SL I V +D G YTCVA N G + S+ VHV P + Q
Sbjct: 930 MLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQI 989
Query: 356 QMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQ 415
G V C+ GNP P++ W K+G + + +FS G L + +
Sbjct: 990 LSTIEGIPVTLPCKASGNPKPSVIWSKKGELI-------STSSAKFSAGADGSLYVVSPG 1042
Query: 416 RGDAGYYVCQAVSVAGSILAKALLEI----------KGASLDGLPPVILQGPANQTLVLG 465
++G YVC A + AG K L + +G S D P +++ G
Sbjct: 1043 GEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQD--------KPVEISVLAG 1094
Query: 466 SSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKS 525
V LPC V P P + W K+ Q + + + +G++ I + D G Y CVA +
Sbjct: 1095 EEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATN 1154
Query: 526 STGEAT 531
G T
Sbjct: 1155 IAGNVT 1160
Score = 176 bits (447), Expect = 1e-43
Identities = 171/572 (29%), Positives = 242/572 (42%), Gaps = 77/572 (13%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
P I+ + ++ V + L C+++ P P + W K+G H LL G
Sbjct: 2104 PNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDG------------HPLLKKPGLS 2151
Query: 124 FFPR--IVHGRRAR-PDEGVYTCVARNYLGAAASRNASLEVAVL-----RDDFRQSPGNV 175
++ A+ D G YTC A N G +N ++ + V D+ Q +
Sbjct: 2152 ISENRSVLKIEDAQVQDTGRYTCEATNVAGKT-EKNYNVNIWVPPNIGGSDELTQ----L 2206
Query: 176 VVAVGEPAVLECVPPRGHPEPSVSWRKDGAR-LKEEEGRITIRGG--KLMMSHTLKSDAG 232
V G L C G P P++ W+K G+ L + GR+ I G +L +S KSDA
Sbjct: 2207 TVIEGNLISLLC-ESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAA 2265
Query: 233 MYVCVASNMAGERESAAAEVMVLERPSFLR---RPVNQVVLADAPVTFLCEVKGDPPPRL 289
+Y CVASN+AG + + V RP+ P +V ++ CEV+G PPP +
Sbjct: 2266 LYSCVASNVAGTAKKEY-NLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTV 2324
Query: 290 RWRKEDGELPTGR-YEIRSD-HSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPP 347
W K+ L + EI + H L + ++ D G Y CVA N G + LSVH PP
Sbjct: 2325 TWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPP 2384
Query: 348 QLV---TQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVS 404
++ P++ SV+ CE G P P+I W K+G V L S + GR
Sbjct: 2385 SIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRM--- 2441
Query: 405 PRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVL 464
L + DAG Y C + AG +I G S+ P ++ + V
Sbjct: 2442 ----LRLMQTTMEDAGQYTCVVRNAAGEER-----KIFGLSVLVPPHIVGENTLEDVKVK 2492
Query: 465 GS-SVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVA 523
SV L C VTGNP P + W KDGQ LQ D+ L I NVQ G Y+C+A
Sbjct: 2493 EKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLA 2552
Query: 524 KSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTG 583
S G + S L + VSP + G+ P + NS
Sbjct: 2553 SSPAGHKSRSFSLNV----FVSP-----TIAGVGSDGNPEDVTVILNS------------ 2591
Query: 584 AAVTSYVIEAFS-PAAGNTWRTVADGVQLETH 614
TS V EA+S P A TW DG LE++
Sbjct: 2592 --PTSLVCEAYSYPPATITW--FKDGTPLESN 2619
Score = 173 bits (438), Expect = 1e-42
Identities = 141/462 (30%), Positives = 214/462 (46%), Gaps = 44/462 (9%)
Query: 84 PCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTC 143
PC A+G P+P I+W NG R T RE + +L G L +V D G Y C
Sbjct: 1287 PCPAKGTPKPTIKWLHNG-RELTGREPGIS---ILEDGTL----LVIASVTPYDNGEYIC 1338
Query: 144 VARNYLGAAASRNASLEV---AVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSW 200
VA N G R +L+V V++D ++ NV V + + L C G P P + W
Sbjct: 1339 VAVNEAGTT-ERKYNLKVHVPPVIKD--KEQVTNVSVLLNQLTNLFC-EVEGTPSPIIMW 1394
Query: 201 RKDGARLKEEEGRITIRGGKLM-MSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPS 259
KD ++ E T+ GK++ + DAG Y C A N+AG + + VL P+
Sbjct: 1395 YKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYF-NIDVLVPPT 1453
Query: 260 FLRR--PVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIR---SDHSLWIG 314
+ P V+ + V C+VKG P P + W K+ L G + L +
Sbjct: 1454 IIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLK 1513
Query: 315 HVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLV--TQPQDQMAAPGESVAFQCETKG 372
+ D+G Y C N+ G+ L++++PP + D + +CET+G
Sbjct: 1514 NARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRG 1573
Query: 373 NPPPAIFWQKEGSQVLLFPSQSLQ-PTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAG 431
P PAI W K+G Q ++ SQ+L G++ PR Q++ D+ Y C +VAG
Sbjct: 1574 LPMPAITWYKDG-QPIMSSSQALYIDKGQYLHIPRAQVS-------DSATYTCHVANVAG 1625
Query: 432 SILAKALLEIKGASLDGLPPVI---LQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDG 488
+ +++ +PP+I L P N+ +V+ S+ L C+ GNP P + W KDG
Sbjct: 1626 TAEKSFHVDVY------VPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDG 1679
Query: 489 QWLQGDDLQFKTMANG-TLYIANVQEMDMGFYSCVAKSSTGE 529
++ +D + A G L I + QE+D G Y CVA S GE
Sbjct: 1680 VPVKAND-NIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGE 1720
Score = 171 bits (433), Expect = 4e-42
Identities = 132/490 (26%), Positives = 227/490 (46%), Gaps = 45/490 (9%)
Query: 51 SLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVRED 110
S++ S + P+ + E+ P + +P +PC + + + +NG +
Sbjct: 420 SVSFSSIVPDAPKVTMPEKTPGYYL---QPGQIPCSVDSLLPFTLSFVRNGVTLGV---- 472
Query: 111 PRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASR---NASLEVAVLRDD 167
+ L S ++ + + DEG Y C+A + G ++ + S V+
Sbjct: 473 ---DQYLKESASV---NLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVI--- 523
Query: 168 FRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDG--ARLKEEEGRITIRGGKLMMSH 225
Q P NV V GE AVL C+ + +++W+++ RL E T+ L +
Sbjct: 524 --QVPNNVTVTPGERAVLTCLIISA-VDYNLTWQRNDRDVRLAEPARIRTLANLSLELKS 580
Query: 226 TLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDP 285
+DAG Y C+ S+ G +A+ + V E P P NQ + V+ +C G P
Sbjct: 581 VKFNDAGEYHCMVSSEGGS-SAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYP 639
Query: 286 PPRLRWRKEDGELP-TGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVH 344
P++ W D + + RY + SD +L+I + + +D G Y C+A NS G + + +L
Sbjct: 640 KPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYI 699
Query: 345 VPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVS 404
P+L+ + + A G+ +C+T G PPP + W K + L+P+ +
Sbjct: 700 EAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLE--------LRPSTFLIID 751
Query: 405 P-RGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLV 463
P G L I Q DAG Y C A++ AG K L++ G PPV +Q PA+ ++
Sbjct: 752 PLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDV------GSPPVFIQEPADVSME 805
Query: 464 LGSSVWLPCRVTGNPQPSVRWKK-DGQWLQGDDLQFKTMA---NGTLYIANVQEMDMGFY 519
+GS+V LPC V G P+P+++W++ D + +++ G L+I N+ D G Y
Sbjct: 806 IGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTY 865
Query: 520 SCVAKSSTGE 529
C A++ G+
Sbjct: 866 ICEAENQFGK 875
Score = 171 bits (433), Expect = 4e-42
Identities = 135/478 (28%), Positives = 211/478 (44%), Gaps = 45/478 (9%)
Query: 68 EQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPR 127
EQ ++ V + L C EG P P I WYK+ +V + +
Sbjct: 1365 EQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNN----------GK 1414
Query: 128 IVHGRRARP-DEGVYTCVARNYLGAAASR---NASLEVAVLRDDFRQSPGNVVVAVGEPA 183
I+ RA P D G Y+C A N G + + + ++ +F P V V +
Sbjct: 1415 ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNF---PNEVSVVLNRDV 1471
Query: 184 VLECVPPRGHPEPSVSWRKDGARLKEEEGRITI--RGGKLMMSHTLKSDAGMYVCVASNM 241
LEC +G P P + W KDG L + + + RG L + + ++D G Y C SN
Sbjct: 1472 ALEC-QVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNA 1530
Query: 242 AGERESAAAEVMVLERPSFLRRPVNQ--VVLADAPVTFLCEVKGDPPPRLRWRKEDGELP 299
AG +++ ++ + PS V VL ++ + CE +G P P + W K+ +
Sbjct: 1531 AG-KQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIM 1589
Query: 300 TGRYEIRSDHS--LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQL---VTQPQ 354
+ + D L I D TYTC N G AE S + V+VPP + + P
Sbjct: 1590 SSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPL 1649
Query: 355 DQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAV 414
++ S+ +C+ GNP P + W K+G V + ++ G+ +L I +
Sbjct: 1650 NKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGK-------KLEIMSA 1702
Query: 415 QRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVL--GSSVWLPC 472
Q D G Y+C A SVAG K +++ +PP I G ++ + + L C
Sbjct: 1703 QEIDRGQYICVATSVAGEKEIKYEVDVL------VPPAIEGGDETSYFIVMVNNLLELDC 1756
Query: 473 RVTGNPQPSVRWKKDGQWLQGDDLQFKTMANG-TLYIANVQEMDMGFYSCVAKSSTGE 529
VTG+P P++ W KDGQ + D FK + NG L IA Q + G Y C+A ++ G+
Sbjct: 1757 HVTGSPPPTIMWLKDGQLIDERD-GFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGD 1813
Score = 170 bits (430), Expect = 1e-41
Identities = 136/470 (28%), Positives = 209/470 (44%), Gaps = 41/470 (8%)
Query: 74 LVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRR 133
+V + +P L C A G P P+I W K+ V T + + + + SG + + +
Sbjct: 1837 VVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLK----IQSSGRV----LQIAKT 1888
Query: 134 ARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPG---NVVVAVGEPAVLECVPP 190
D G YTCVA N AA +++ V + G N V V P LEC
Sbjct: 1889 LLEDAGRYTCVATN---AAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLEC-KA 1944
Query: 191 RGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLK-SDAGMYVCVASNMAGERESAA 249
G+P P ++W KD L + G+++ + + SDAG+Y CVA N AG E
Sbjct: 1945 AGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFY 2004
Query: 250 AEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT---GRYEIR 306
+ + V PS V+ + PV CE +G P P L W K+ + + G +
Sbjct: 2005 S-LQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLS 2063
Query: 307 SDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAF 366
L + D G YTCVA N+ G + L V+VPP ++ + Q+ ++V
Sbjct: 2064 GGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVEL 2123
Query: 367 QCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQA 426
C++ PPP + W K+G +L P S+ R L I Q D G Y C+A
Sbjct: 2124 LCQSDAIPPPTLTWLKDGHPLLKKPGLSISEN-------RSVLKIEDAQVQDTGRYTCEA 2176
Query: 427 VSVAGSILAKALLEIKGASLDGLPPVILQGPANQ----TLVLGSSVWLPCRVTGNPQPSV 482
+VAG + I +PP I G +++ T++ G+ + L C +G P P++
Sbjct: 2177 TNVAGKTEKNYNVNI------WVPPNI--GGSDELTQLTVIEGNLISLLCESSGIPPPNL 2228
Query: 483 RWKKDGQWLQGDDLQFKTMANG--TLYIANVQEMDMGFYSCVAKSSTGEA 530
WKK G + D + + +G L I+ ++ D YSCVA + G A
Sbjct: 2229 IWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTA 2278
Score = 168 bits (425), Expect = 4e-41
Identities = 136/462 (29%), Positives = 205/462 (44%), Gaps = 44/462 (9%)
Query: 82 TLPCRAEGRPRPNIEWYKNGARVAT---VREDPRAHRLLLPSGALFFPRIVHGRRARPDE 138
TL C+A G P P + W K+G V +R + +L + S D
Sbjct: 1660 TLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEI------------DR 1707
Query: 139 GVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNV---VVAVGEPAVLECVPPRGHPE 195
G Y CVA + G + EV VL + +V V L+C G P
Sbjct: 1708 GQYICVATSVAG---EKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDC-HVTGSPP 1763
Query: 196 PSVSWRKDGARLKEEEG-RITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMV 254
P++ W KDG + E +G +I + G KL+++ S+ G+Y C+A+N AG+ + EV V
Sbjct: 1764 PTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKK-EFEVTV 1822
Query: 255 LERPSFLRRPVNQ-VVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIR---SDHS 310
P+ +++ VV+ PV C G P P + W K+D + T + ++ S
Sbjct: 1823 HVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRV 1882
Query: 311 LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQL--VTQPQDQMAAPGESVAFQC 368
L I ED G YTCVA N+ G + L VH PP L + ++ V +C
Sbjct: 1883 LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLEC 1942
Query: 369 ETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVS 428
+ GNP P I W K+ LL S S+ R + ++I + Q DAG Y C A++
Sbjct: 1943 KAAGNPVPVITWYKDNR--LLSGSTSMTFLNRGQI-----IDIESAQISDAGIYKCVAIN 1995
Query: 429 VAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDG 488
AG+ L++ A P I +V+ + V L C G P PS+ W KDG
Sbjct: 1996 SAGATELFYSLQVHVA------PSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDG 2049
Query: 489 QWLQGDDLQFKTMANG-TLYIANVQEMDMGFYSCVAKSSTGE 529
+ + ++ G L + + Q D G Y+CVA ++ GE
Sbjct: 2050 SPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGE 2091
Score = 163 bits (412), Expect = 1e-39
Identities = 143/517 (27%), Positives = 214/517 (41%), Gaps = 54/517 (10%)
Query: 75 VSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRA 134
V G +L C + P P I WYKNG + H +L G +++H ++A
Sbjct: 3071 VREGTSVSLECESNAVPPPVITWYKNGRMITE-----STHVEILADG-----QMLHIKKA 3120
Query: 135 R-PDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGH 193
D G Y C A N G +N L V V +V + P L C G
Sbjct: 3121 EVSDTGQYVCRAINVAGRD-DKNFHLNVYVPPSIEGPEREVIVETISNPVTLTC-DATGI 3178
Query: 194 PEPSVSWRKDGARLKEEEG---RITIRGGKLMMSHTLKSDAGMYVCVASNMAGERES-AA 249
P P+++W K+ R++ + RI G KL ++ + SD+G Y C+ASNM G+ +
Sbjct: 3179 PPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYF 3238
Query: 250 AEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYE-IR-- 306
+ V + P + VL V +C G P P ++W K+ + +G E IR
Sbjct: 3239 LSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVS 3298
Query: 307 -SDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQL---VTQPQDQMAAPGE 362
+ +L I D G YTCVA N G + +L+V+V P + + + M
Sbjct: 3299 ANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDT 3358
Query: 363 SVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYY 422
S+ +C G PPP I W K G + L L G+ + I Q D Y
Sbjct: 3359 SINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQV-------IRIVRAQVSDVAVY 3411
Query: 423 VCQAVSVAGSILAKALLEIKGASLDGLPPVIL---QGPANQTLVLGSSVWLPCRVTGNPQ 479
C A + AG ++ K +L P + G T++ GSS + C G P
Sbjct: 3412 TCVASNRAG-------VDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPA 3464
Query: 480 PSVRWKKDGQWLQGDDLQFKTMANG-TLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKM 538
PS+ W +DGQ L G D +G L + + D G Y+C+A + GE + LK+
Sbjct: 3465 PSMAWLRDGQPL-GLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKV 3523
Query: 539 REDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLT 575
EP G+ ++ I N + LT
Sbjct: 3524 -----------LEPPHINGSEEHEEISVIVNNPLELT 3549
Score = 159 bits (403), Expect = 1e-38
Identities = 144/488 (29%), Positives = 207/488 (42%), Gaps = 51/488 (10%)
Query: 63 MPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGA 122
+P I L G P TLPC+A G P+P++ W K G ++T A G+
Sbjct: 980 LPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAG----ADGS 1035
Query: 123 LFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDF-------RQSPGNV 175
L+ + G Y C A N G A R L V V F + P +
Sbjct: 1036 LYVV-----SPGGEESGEYVCTATNTAG-YAKRKVQLTVYVRPRVFGDQRGLSQDKPVEI 1089
Query: 176 VVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRIT-IRGGKLMMSHTLKSDAGMY 234
V GE L C + P P ++W K+ + R T + G + ++ T SD+GMY
Sbjct: 1090 SVLAGEEVTLPC-EVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMY 1148
Query: 235 VCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKE 294
+CVA+N+AG + A ++ V P R P + V V C +G P P + W K
Sbjct: 1149 LCVATNIAG-NVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKG 1207
Query: 295 DGE-LPTGRYEIRS-DHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQL--V 350
L G + + + D +L I + D G YTCVA N G E +L V PP + +
Sbjct: 1208 GSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDL 1267
Query: 351 TQPQD---QMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGR---FSVS 404
P + Q + + F C KG P P I W G ++ TGR S+
Sbjct: 1268 EPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGREL----------TGREPGISIL 1317
Query: 405 PRGQLNITA-VQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVI--LQGPANQT 461
G L + A V D G Y+C AV+ AG+ K L++ +PPVI + N +
Sbjct: 1318 EDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVH------VPPVIKDKEQVTNVS 1371
Query: 462 LVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANG-TLYIANVQEMDMGFYS 520
++L L C V G P P + W KD + + +T+ NG L + D G YS
Sbjct: 1372 VLLNQLTNLFCEVEGTPSPIIMWYKDNVQVT-ESSTIQTVNNGKILKLFRATPEDAGRYS 1430
Query: 521 CVAKSSTG 528
C A + G
Sbjct: 1431 CKAINIAG 1438
Score = 157 bits (397), Expect = 7e-38
Identities = 143/533 (26%), Positives = 213/533 (39%), Gaps = 68/533 (12%)
Query: 70 PPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVAT---VREDPRAHRLLLPSGALFFP 126
P ++ + TL C A P ++ WYK+G + + V H L + +
Sbjct: 2681 PKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQI--- 2737
Query: 127 RIVHGRRARPDEGVYTCVARNYLG-----------AAASRNASLEVAVLRDDFRQSPGNV 175
D G YTCVA N G S E+ + D R
Sbjct: 2738 ---------SDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKD 2788
Query: 176 VVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLK-SDAGMY 234
V+ + P L C P P+++W KDG L + + + GG+++ K DAG Y
Sbjct: 2789 VI-INNPISLYC-ETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRY 2846
Query: 235 VCVASNMAGERESAAAEVMVLERPSFLRR----PVNQVVLADAPVTFLCEVKGDPPPRLR 290
CVA N AGE +S +V VL P P VL + C G P PR
Sbjct: 2847 TCVAVNEAGE-DSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNS 2905
Query: 291 WRKEDGELPTGRYE--IRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQ 348
W+K+ L + + + L I + D G Y CVAEN+ G A+ +L+VHVPP
Sbjct: 2906 WQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPS 2965
Query: 349 LVTQPQDQM-AAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRG 407
++ + + ++ CE G PPP + W K + L + + P GR
Sbjct: 2966 VIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGR------- 3018
Query: 408 QLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVL--- 464
L I + D G Y C A++ AG K L + +PP I + V+
Sbjct: 3019 TLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVY------VPPSIKDHDSESLSVVNVR 3072
Query: 465 -GSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANG-TLYIANVQEMDMGFYSCV 522
G+SV L C P P + W K+G+ + + + +A+G L+I + D G Y C
Sbjct: 3073 EGTSVSLECESNAVPPPVITWYKNGRMIT-ESTHVEILADGQMLHIKKAEVSDTGQYVCR 3131
Query: 523 AKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLT 575
A + G R+D + PS P + V+ E N +TLT
Sbjct: 3132 AINVAG----------RDDKNFHLNVYVPPSIE--GPEREVIVETISNPVTLT 3172
Score = 154 bits (388), Expect = 7e-37
Identities = 131/504 (25%), Positives = 205/504 (40%), Gaps = 41/504 (8%)
Query: 50 PSLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVRE 109
P +NGS E+ ++ V P L C A G P P + W K+G R
Sbjct: 3527 PHINGS------------EEHEEISVIVNNPLELTCIASGIPAPKMTWMKDG------RP 3568
Query: 110 DPRAHRLLLPSGALFFPRIVHGRRAR-PDEGVYTCVARNYLGAAASRNASLEVAVLRDDF 168
P+ ++ G ++ A+ D G YTC+A + G
Sbjct: 3569 LPQTDQVQTLGGG----EVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAG 3624
Query: 169 RQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGK-LMMSHTL 227
P ++ V LEC P P ++W ++G RL+ + GG+ L +++
Sbjct: 3625 TDEPRDITVLRNRQVTLECKSD-AVPPPVITWLRNGERLQATPRVRILSGGRYLQINNAD 3683
Query: 228 KSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPP 287
D Y CVASN+AG + + + V P+ P + V+L + C +G P P
Sbjct: 3684 LGDTANYTCVASNIAG-KTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTP 3742
Query: 288 RLRWRKEDGELPTG---RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVH 344
R+ WRK DG + G RY I + L I D G Y C+A N+ G L VH
Sbjct: 3743 RITWRK-DGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVH 3801
Query: 345 VPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVS 404
VPP + P + CE G P P+I W+K G + + +Q+ + +
Sbjct: 3802 VPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQN-----SYRLL 3856
Query: 405 PRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVL 464
G L I + D Y C + AG L ++ +PP I P + +
Sbjct: 3857 SSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQ------VPPSIADEPTDFLVTK 3910
Query: 465 GSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAK 524
+ + C +G P PS+ W K+G L ++ +++G + I Q G Y+CVA+
Sbjct: 3911 HAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVAR 3970
Query: 525 SSTGEATWSGWLKMREDWGVSPDP 548
++ G A L + E + P P
Sbjct: 3971 NAAGSAHRHVTLHVHEPPVIQPQP 3994
Score = 151 bits (382), Expect = 4e-36
Identities = 131/451 (29%), Positives = 187/451 (41%), Gaps = 50/451 (11%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
PRI V+ A LPC A+G P P I W K+ +A + A P G L
Sbjct: 4169 PRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAE----PYGEL 4224
Query: 124 FFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPA 183
+V D G YTCVA N G + SL V VL F + PG+V + GE
Sbjct: 4225 ILENVV-----LEDSGFYTCVANNAAGED-THTVSLTVHVL-PTFTELPGDVSLNKGEQL 4277
Query: 184 VLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAG 243
L C G P P ++W + + + +L++ K D+G YVC A N G
Sbjct: 4278 RLSC-KATGIPLPKLTWTFNNNIIPAHFDSVNGHS-ELVIERVSKEDSGTYVCTAENSVG 4335
Query: 244 ERESAAAEVMVLERPSFLRR-PVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTG- 301
+ A V V E P F P N + CEVKGDP P ++W ++ ++
Sbjct: 4336 FVK-AIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISH 4394
Query: 302 RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPG 361
R + SL I ED G YTCVA N G E S SL++ PP + +P + + G
Sbjct: 4395 RIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAG 4454
Query: 362 ESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGY 421
+ C+ G P P I W ++G S+ R +V L I Q+ D
Sbjct: 4455 GKIILNCQATGEPQPTITWSRQG--------HSISWDDRVNVLSNNSLYIADAQKEDTSE 4506
Query: 422 YVCQAVSVAGSILAKALLEIKGASLDGLPPVILQ--GPANQ-------TLVLGSSVWLPC 472
+ C A ++ GS+L + PVI+Q G +Q ++ G +
Sbjct: 4507 FECVARNLMGSVLVRV-------------PVIVQVHGGFSQWSAWRACSVTCGKGIQKRS 4553
Query: 473 RVTGNPQPSVRWKKDGQWLQGDDLQFKTMAN 503
R+ P P+ G+ QG DL+ + N
Sbjct: 4554 RLCNQPLPA----NGGKPCQGSDLEMRNCQN 4580
Score = 142 bits (357), Expect = 3e-33
Identities = 127/499 (25%), Positives = 206/499 (41%), Gaps = 55/499 (11%)
Query: 62 AMPRIV---EQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLL 118
A P I+ P ++ V +L C A G P P+I W+K+G V+ ++ + +
Sbjct: 2382 APPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSL------SNSVRI 2435
Query: 119 PSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDF---RQSPGNV 175
SG + + D G YTCV RN AA ++VL + +V
Sbjct: 2436 LSGGRMLRLM---QTTMEDAGQYTCVVRN---AAGEERKIFGLSVLVPPHIVGENTLEDV 2489
Query: 176 VVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGK-LMMSHTLKSDAGMY 234
V + L C G+P P ++W KDG L+E+E I GG+ L +++ G Y
Sbjct: 2490 KVKEKQSVTLTC-EVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRY 2548
Query: 235 VCVASNMAGERESAAAEVMVLERPSFLR-----RPVNQVVLADAPVTFLCEVKGDPPPRL 289
C+AS+ AG + S + + V P+ P + V+ ++P + +CE PP +
Sbjct: 2549 TCLASSPAGHK-SRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATI 2607
Query: 290 RWRKEDGELPTGRYEIR---SDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVP 346
W K+ L + R IR +L I + ++ G Y+CVA N G + V++P
Sbjct: 2608 TWFKDGTPLESNR-NIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIP 2666
Query: 347 PQLVT--------QPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPT 398
P + P++ ++ +CE P ++ W K+G Q L+
Sbjct: 2667 PIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDG--------QPLKSD 2718
Query: 399 GRFSVSPRGQ-LNITAVQRGDAGYYVCQAVSVAGSILAKALLEI-------KGASLDGLP 450
+++ G L I Q D G Y C A ++AG + I K + +
Sbjct: 2719 DHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNML 2778
Query: 451 PVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIAN 510
G A +++ + + L C P P++ W KDG L D L I
Sbjct: 2779 DTGRNGEAKD-VIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPR 2837
Query: 511 VQEMDMGFYSCVAKSSTGE 529
+ D G Y+CVA + GE
Sbjct: 2838 AKVEDAGRYTCVAVNEAGE 2856
Score = 133 bits (334), Expect = 1e-30
Identities = 132/482 (27%), Positives = 197/482 (40%), Gaps = 48/482 (9%)
Query: 68 EQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVAT-----VREDPRAHRLLLPSGA 122
E P D+ V GE L C A G P P I+W K+G +A+ +R L + GA
Sbjct: 3251 EIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNI-YGA 3309
Query: 123 LFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAV---LRDDFRQSPGNVVVAV 179
L D G YTCVA N G R +L V V +R + + ++ V
Sbjct: 3310 L-----------TSDTGKYTCVATNPAG-EEDRIFNLNVYVTPTIRGN-KDEAEKLMTLV 3356
Query: 180 GEPAVLECVPPRGHPEPSVSWRKDGARLK-EEEGRITIRGGKLMMSHTLKSDAGMYVCVA 238
+EC G P P ++W K+G L R+ G + + SD +Y CVA
Sbjct: 3357 DTSINIEC-RATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVA 3415
Query: 239 SNMAGERESAAAEVMVLERPSFLRRPVNQ--VVLADAPVTFLCEVKGDPPPRLRWRKEDG 296
SN AG ++ + V P+ + VL + + C G P P + W ++
Sbjct: 3416 SNRAGV-DNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQ 3474
Query: 297 ELPTGRYEIRSDHSLWIGHVSA--EDEGTYTCVAENSVGRAEASGSLSVHVPPQL--VTQ 352
L + S H + + + A ED G YTC+A N G L V PP + +
Sbjct: 3475 PLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEE 3534
Query: 353 PQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNIT 412
++ + C G P P + W K+G L + +Q G V L I+
Sbjct: 3535 HEEISVIVNNPLELTCIASGIPAPKMTWMKDGRP--LPQTDQVQTLGGGEV-----LRIS 3587
Query: 413 AVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVI--LQGPANQTLVLGSSVWL 470
Q D G Y C A S AG + L+ + +PP I P + T++ V L
Sbjct: 3588 TAQVEDTGRYTCLASSPAGDDDKEYLVRVH------VPPNIAGTDEPRDITVLRNRQVTL 3641
Query: 471 PCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGT-LYIANVQEMDMGFYSCVAKSSTGE 529
C+ P P + W ++G+ LQ + + ++ G L I N D Y+CVA + G+
Sbjct: 3642 ECKSDAVPPPVITWLRNGERLQATP-RVRILSGGRYLQINNADLGDTANYTCVASNIAGK 3700
Query: 530 AT 531
T
Sbjct: 3701 TT 3702
Score = 116 bits (290), Expect = 2e-25
Identities = 80/288 (27%), Positives = 128/288 (44%), Gaps = 27/288 (9%)
Query: 63 MPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGA 122
+P E P D+ +++GE L C+A G P P + W N + + H
Sbjct: 4259 LPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGH-------- 4310
Query: 123 LFFPRIVHGRRARPDEGVYTCVARNYLG--AAASRNASLEVAVLRDDFRQSPGNVVVAVG 180
+V R ++ D G Y C A N +G A E V + D+ P N + +G
Sbjct: 4311 ---SELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDY---PSNWIEPLG 4364
Query: 181 EPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASN 240
A+L C +G P P++ W + G ++ + G L + T+ DAG Y CVA+N
Sbjct: 4365 GNAILNC-EVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATN 4423
Query: 241 MAGERESAAAEVMVLERPSFLR-RPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELP 299
AG E + + + L+ P + PV V+ A + C+ G+P P + W ++ +
Sbjct: 4424 EAGVVERSMS--LTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSIS 4481
Query: 300 -TGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVP 346
R + S++SL+I ED + CVA N + GS+ V VP
Sbjct: 4482 WDDRVNVLSNNSLYIADAQKEDTSEFECVARNLM------GSVLVRVP 4523
Score = 60.1 bits (144), Expect = 1e-08
Identities = 39/144 (27%), Positives = 72/144 (50%), Gaps = 7/144 (4%)
Query: 409 LNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSV 468
L+I V D G+Y C AVS AG+ A+ ++ PP ++Q P N T+ G
Sbjct: 484 LDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE------PPPVIQVPNNVTVTPGERA 537
Query: 469 WLPCRVTGNPQPSVRWKKDGQWLQ-GDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSST 527
L C + ++ W+++ + ++ + + +T+AN +L + +V+ D G Y C+ S
Sbjct: 538 VLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEG 597
Query: 528 GEATWSGWLKMREDWGVSPDPPTE 551
G + S +L ++E V+ P +
Sbjct: 598 GSSAASVFLTVQEPPKVTVMPKNQ 621
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 215 bits (548), Expect = 2e-55
Identities = 153/475 (32%), Positives = 216/475 (45%), Gaps = 36/475 (7%)
Query: 63 MPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRL-LLPSG 121
+P I PP + VS + A LPC+A+G P P + W K+ V DPR+ R +LP G
Sbjct: 2481 VPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD-----RVPLDPRSPRFEILPEG 2535
Query: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDD-FRQSPGNVVVAVG 180
+L ++ D G Y C+A N +A S ++ VL SP N+ +
Sbjct: 2536 SLRIQPVL-----AQDAGHYLCLASN---SAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 2587
Query: 181 EPAVLECVPPRGHPEPSVSWRKDGARLK---EEEGRITIRGGKLMMSHTLKSDAGMYVCV 237
PA+L C G P+P V W KDG +L ++ + L+++ D+ + CV
Sbjct: 2588 TPALLPC-EASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECV 2646
Query: 238 ASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGE 297
SN GE +V V P+ + V APV C G P P + W K +
Sbjct: 2647 VSNEVGEAHRLY-QVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ 2705
Query: 298 LPT--GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQD 355
L Y + +L IG G YTC A NS G A L+V P + P
Sbjct: 2706 LGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSV 2765
Query: 356 QMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQ 415
A E V CE G P P I WQKEG V S V P GQL I
Sbjct: 2766 VRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST--------QVLPGGQLRIAHAS 2817
Query: 416 RGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVT 475
DAG Y+C A + AGS + K L ++ +PPVI G + + GS +LPC+
Sbjct: 2818 PEDAGNYLCIAKNSAGSAMGKTRLVVQ------VPPVIENGLPDLSTTEGSHAFLPCKAR 2871
Query: 476 GNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEA 530
G+P+P++ W KDGQ + G + +F +G L + N++ D G Y+C A+++ G A
Sbjct: 2872 GSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRA 2926
Score = 212 bits (540), Expect = 2e-54
Identities = 154/488 (31%), Positives = 219/488 (44%), Gaps = 35/488 (7%)
Query: 62 AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSG 121
A P + P + E LPC A G PRP I W K G VAT +LP G
Sbjct: 2755 ASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVAT-----GVSTQVLPGG 2809
Query: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGE 181
L RI H + D G Y C+A+N G+A + V + ++ G
Sbjct: 2810 QL---RIAHA--SPEDAGNYLCIAKNSAGSAMGKTRL--VVQVPPVIENGLPDLSTTEGS 2862
Query: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIR-GGKLMMSHTLKSDAGMYVCVASN 240
A L C RG PEP+++W KDG + EG+ TI+ G+L++ + DAG Y C A N
Sbjct: 2863 HAFLPC-KARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAEN 2921
Query: 241 MAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT 300
G R + +L P F P ++ + + C +G P PR+ W D +
Sbjct: 2922 AVG-RARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTE 2980
Query: 301 GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAP 360
G E +L VS ED GTY C AEN VGR +A + V P L + + P
Sbjct: 2981 GVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEP 3040
Query: 361 -GESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDA 419
G S+ C +G+P P I W K+G L+ + G L I +R DA
Sbjct: 3041 VGGSIQLDCVVRGDPVPDIHWIKDG--------LPLRGSHLRHQLQNGSLTIHRTERDDA 3092
Query: 420 GYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQ 479
G Y C A + G +L ++ A PV P + T+ G V L C+ TG P
Sbjct: 3093 GRYQCLAENEMGVAKKVVILVLQSA------PVFQVEPQDMTVRSGDDVALRCQATGEPT 3146
Query: 480 PSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMR 539
P++ W + GQ L+ + +T+ +G+L++ NV+ D G Y CVA + G AT +L +R
Sbjct: 3147 PTIEWLQAGQPLRA-SRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3205
Query: 540 ED----WG 543
+ WG
Sbjct: 3206 GEPQGSWG 3213
Score = 190 bits (483), Expect = 7e-48
Identities = 169/548 (30%), Positives = 231/548 (42%), Gaps = 58/548 (10%)
Query: 50 PSLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVRE 109
P+ + GP+DA+ LV G+ A L C + P P + WYK+G +
Sbjct: 1838 PAFRQAPRGPQDAV----------LVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL--- 1884
Query: 110 DPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFR 169
A R G R+ D+G+Y+C N G A R +L V V
Sbjct: 1885 ---AQRTQALRGG---QRLEIQEAQVSDKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFEN 1937
Query: 170 QSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGR---ITIRGGKLMMSHT 226
V G P VL C G P P+V+W KD R+ E + RGG+L +S
Sbjct: 1938 PKTETVSQVAGSPLVLTC-DVSGVPAPTVTWLKD--RMPVESSAVHGVVSRGGRLQLSRL 1994
Query: 227 LKSDAGMYVCVASNMAGE-RESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDP 285
+ AG Y CVA N E R+ V+V R VL V CE G P
Sbjct: 1995 QPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQP 2054
Query: 286 PPRLRWRKEDGEL-----PTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGS 340
PP + W K+ L P R+ + SL + + A D G YTCVA N G +
Sbjct: 2055 PPDVAWLKDGSPLGQDMGPHLRFYL-DGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHT 2113
Query: 341 LSVHVPPQLVTQPQD----QMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQ 396
++V VPP + Q D ++ PGE V C +G+PP + W K+G + L L
Sbjct: 2114 VNVLVPP-TIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLH 2172
Query: 397 PTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVI--L 454
+G L I+ VQ DAG + C A S AG L+++ +PPV+ +
Sbjct: 2173 GSGH-------TLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ------VPPVLEPV 2219
Query: 455 QGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEM 514
+ + +V GS V LPC G P P V W KDG+ L L+ +L + V
Sbjct: 2220 EFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLE----QGPSLQLEAVGAG 2275
Query: 515 DMGFYSCVAKSSTGEATWSGWLKMREDWGVSPD-PPTEPSSPPGAPSQPVVTEITKNSIT 573
D G YSCVA S GEA L + E + PTE S PGAP + +
Sbjct: 2276 DSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPN 2335
Query: 574 LTWKPNPQ 581
+TW + Q
Sbjct: 2336 ITWHKDGQ 2343
Score = 189 bits (479), Expect = 2e-47
Identities = 157/483 (32%), Positives = 212/483 (43%), Gaps = 55/483 (11%)
Query: 63 MPRIVEQPPDLLVSR--GEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPS 120
+P E P VS+ G P L C G P P + W K+ V E H ++
Sbjct: 1931 VPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPV----ESSAVHGVVSRG 1986
Query: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVV---V 177
G L R+ + G YTCVA N A VAVL +S G V
Sbjct: 1987 GRLQLSRLQPAQA-----GTYTCVAEN---TQAEARKDFVVAVLVAPRIRSSGVAREHHV 2038
Query: 178 AVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEG---RITIRGGKLMMSHTLKSDAGMY 234
G+ L+C G P P V+W KDG+ L ++ G R + GG L++ SDAG Y
Sbjct: 2039 LEGQEVRLDCEAD-GQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAY 2097
Query: 235 VCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAP---VTFLCEVKGDPPPRLRW 291
CVA N AGE ++ V VL P+ + L P VT +C V+G PP + W
Sbjct: 2098 TCVAHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSW 2156
Query: 292 RKEDGELPTGRYEI--RSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQL 349
K+ LP + + S H+L I V D G +TCVA + G A+ + +L V VPP L
Sbjct: 2157 LKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVL 2216
Query: 350 --VTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRG 407
V D + G V CE +G P P + W K+G +L SQSL+
Sbjct: 2217 EPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLL---SQSLE--------QGP 2265
Query: 408 QLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQG--PANQTLVLG 465
L + AV GD+G Y C AVS AG L + PP I P +L G
Sbjct: 2266 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME------PPHIEDSGQPTELSLTPG 2319
Query: 466 SSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKS 525
+ + L C G PQP++ W KDGQ L + N + ++ D G Y+C+A+S
Sbjct: 2320 APMELLCDAQGTPQPNITWHKDGQAL-------TRLENNSRATRVLRVRDAGLYTCLAES 2372
Query: 526 STG 528
G
Sbjct: 2373 PAG 2375
Score = 181 bits (459), Expect = 4e-45
Identities = 148/493 (30%), Positives = 215/493 (43%), Gaps = 52/493 (10%)
Query: 69 QPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRI 128
QP +L ++ G P L C A+G P+PNI W+K+G + + + RA R+L
Sbjct: 2310 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVL----------- 2358
Query: 129 VHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVV----------VA 178
R R D G+YTC+A + GA S V V Q+P N+V +A
Sbjct: 2359 ----RVR-DAGLYTCLAESPAGAIEK---SFRVRV------QAPPNIVGPRGPRFVVGLA 2404
Query: 179 VGEPAVLECVPPRGHPEPSVSWRKDGARLKEE-EGRITIRGGKLMMSHTLKSDAGMYVCV 237
G+ VLEC P P ++W +DG L+E+ + RG L + +D+G Y C
Sbjct: 2405 PGQ-LVLEC-SVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCT 2462
Query: 238 ASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGE 297
A N AG S A V + P+ P V + C+ G P P + WRK+
Sbjct: 2463 ARNAAGST-SVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVP 2521
Query: 298 LP--TGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQD 355
L + R+EI + SL I V A+D G Y C+A NS G L V PP + P +
Sbjct: 2522 LDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSN 2581
Query: 356 QMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQ 415
CE G+P P + W K+G Q L F Q G + + P L +TA
Sbjct: 2582 LTLTAHTPALLPCEASGSPKPLVVWWKDG-QKLDFRLQQ----GAYRLLPSNALLLTAPG 2636
Query: 416 RGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVT 475
D+ + C + G A L ++ +PP I + T+ + + V L C T
Sbjct: 2637 PQDSAQFECVVSNEVGE--AHRLYQVTVH----VPPTIADDQTDFTVTMMAPVVLTCHST 2690
Query: 476 GNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGW 535
G P P+V W K G L ++ +G L I + G Y+C A++S G A +
Sbjct: 2691 GIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVF 2750
Query: 536 LKMREDWGVSPDP 548
L ++ V P P
Sbjct: 2751 LTVQASPVVKPLP 2763
Score = 176 bits (446), Expect = 1e-43
Identities = 151/496 (30%), Positives = 218/496 (43%), Gaps = 44/496 (8%)
Query: 63 MPRIVEQPPD---LLVSR-GEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLL 118
+P ++Q D LVSR GE T+ C G P ++ W K+G + P + R LL
Sbjct: 2118 VPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL------PLSQRTLL 2171
Query: 119 PSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRD-DFRQSPGNVVV 177
G+ RI + A D G++TCVA + G A RN +L+V V + + +VVV
Sbjct: 2172 -HGSGHTLRISKVQLA--DAGIFTCVAASPAGVA-DRNFTLQVQVPPVLEPVEFQNDVVV 2227
Query: 178 AVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCV 237
G L C RG P P VSW KDG L + +G L + D+G Y CV
Sbjct: 2228 VRGSLVELPC-EARGVPLPLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSCV 2283
Query: 238 ASNMAGERESAAAEVMVLERPSF--LRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKED 295
A + AGE ++ V+E P +P + AP+ LC+ +G P P + W K+
Sbjct: 2284 AVSEAGEARRHF-QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG 2342
Query: 296 GELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQD 355
L R+ L + D G YTC+AE+ G E S + V PP +V
Sbjct: 2343 QALTRLENNSRATRVLRV-----RDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGP 2397
Query: 356 QMA---APGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNIT 412
+ APG+ V +C + P P I W ++G + GRF L +
Sbjct: 2398 RFVVGLAPGQLV-LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF-------LQLQ 2449
Query: 413 AVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPC 472
A+ D+G Y C A + AGS +EI P I GP + + + LPC
Sbjct: 2450 ALSTADSGDYSCTARNAAGSTSVAFRVEIHTV------PTIRSGPPAVNVSVNQTALLPC 2503
Query: 473 RVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATW 532
+ G P P V W+KD L +F+ + G+L I V D G Y C+A +S G
Sbjct: 2504 QADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQ 2563
Query: 533 SGWLKMREDWGVSPDP 548
L++ E ++P P
Sbjct: 2564 GRDLRVLEPPAIAPSP 2579
Score = 175 bits (443), Expect = 3e-43
Identities = 140/497 (28%), Positives = 214/497 (43%), Gaps = 48/497 (9%)
Query: 73 LLVSRGEPATLPCRAEGRPRPNIEWYKNGARV----ATVREDPRAHRLLLPSGALFFPRI 128
L V G P +L C G P P I W K+G + A ++ RLL
Sbjct: 981 LTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYL--------- 1031
Query: 129 VHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDF--RQSPGNVVVAVGEPAVLE 186
G+ EG YTC N +G + S++ LEV V R+ P V V A LE
Sbjct: 1032 --GQAQLAQEGTYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLE 1088
Query: 187 CVPPRGHPEPSVSWRKDGARLKEEEG-RITIRGGKLMMSHTLKSDAGMYVCVASNMAGER 245
C G P P+V+W +DG + E G ++ +G L + + G Y CVA N+AG
Sbjct: 1089 C-NATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 1147
Query: 246 ESAAAEVMVLERPSFLRR--PVNQVVLA-DAPVTFLCEVKGDPPPRLRWRKEDGELPTGR 302
E E+ VL P + P+ + A +P+T LCE G PPP +RW + + + G
Sbjct: 1148 ERKF-ELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGE 1206
Query: 303 --YEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQM--A 358
Y + L + +D G Y+C+A N G A + S+ V VPP + + +++
Sbjct: 1207 DTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKV 1266
Query: 359 APGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGD 418
G++ C G+P P + W K+G + + + P G L +
Sbjct: 1267 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVL-------LQVLQANLSS 1319
Query: 419 AGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQ-----TLVLGSSVWLPCR 473
AG+Y C A + G L + L P IL G + T+ + + + L C
Sbjct: 1320 AGHYSCIAANAVGEKTKHFQLSVL------LAPTILGGAEDSADEEVTVTVNNPISLICE 1373
Query: 474 VTGNPQPSVRWKKDGQWLQGD-DLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATW 532
P P++ W KDG + ++Q +G L I N Q+ D G Y+CV + GEA
Sbjct: 1374 ALAFPSPNITWMKDGAPFEASRNIQLLPGTHG-LQILNAQKEDAGQYTCVVTNELGEAVK 1432
Query: 533 SGWLKMREDWGVSPDPP 549
+ +++ +S D P
Sbjct: 1433 NYHVEVLIPPSISKDDP 1449
Score = 170 bits (430), Expect = 1e-41
Identities = 184/655 (28%), Positives = 267/655 (40%), Gaps = 79/655 (12%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
P I+ + ++ V E L C++ P P + W+K+G + +PR L AL
Sbjct: 880 PSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPL-----EPRPGVHLSADKAL 934
Query: 124 FFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPA 183
+ R D G YTC A N G + ++ +L V V + + V G P
Sbjct: 935 ----LQVDRADVWDAGHYTCEALNQAGRS-EKHYNLNVWVAPVFPLRESHTLTVREGHPT 989
Query: 184 VLECVPPRGHPEPSVSWRKDGARLKEEEG---RITIRGGKLMMSHTLKSDAGMYVCVASN 240
L C RG P P +SWRKDG L E ++ G L + + G Y C SN
Sbjct: 990 SLSC-ECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN 1048
Query: 241 MAGER-ESAAAEVMVLERPSFLRRPVNQV-VLADAPVTFLCEVKGDPPPRLRWRKEDGEL 298
+ G + EV V + + R P QV V+ D T C G PPP + W + DG+
Sbjct: 1049 VVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWER-DGQ- 1106
Query: 299 PTGR---YEIRSD-HSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLV--TQ 352
P G ++++ SL + A G Y+CVAEN GRAE LSV VPP+L+
Sbjct: 1107 PVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLD 1166
Query: 353 PQDQMAAPGES-VAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNI 411
P + A S + CE G PPPAI W + V P + + ++ L +
Sbjct: 1167 PLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVS--PGEDT-----YLLAGGWMLKM 1219
Query: 412 TAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVL--GSSVW 469
T Q D+G Y C A + AG +E+ +PP I + + + G +
Sbjct: 1220 TQTQEQDSGLYSCLASNEAGEARRNFSVEVL------VPPSIENEDLEEVIKVLDGQTAH 1273
Query: 470 LPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGE 529
L C VTG+PQP + W KDG+ L D + L + G YSC+A ++ GE
Sbjct: 1274 LMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGE 1333
Query: 530 ATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSY 589
T L V P + A + VT N I+L
Sbjct: 1334 KTKHFQL------SVLLAPTILGGAEDSADEEVTVT--VNNPISL--------------- 1370
Query: 590 VIEAFS-PAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRA----VGAWGLSEPSPVS 644
+ EA + P+ TW + DG E L P T L ++ A G + + +
Sbjct: 1371 ICEALAFPSPNITW--MKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 1428
Query: 645 EPVRTQDSS----PSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGP 695
E V+ PS +DP G+ G+ EV ++ + L SW V P
Sbjct: 1429 EAVKNYHVEVLIPPSISKDDP-LGEVGVKEVKTKVNSTLTLECE----SWAVPPP 1478
Score = 168 bits (425), Expect = 4e-41
Identities = 149/499 (29%), Positives = 211/499 (42%), Gaps = 75/499 (15%)
Query: 72 DLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHG 131
++ V+ P +L C A P PNI W K+GA R LLP HG
Sbjct: 1359 EVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQ-----LLPG--------THG 1405
Query: 132 RRA----RPDEGVYTCVARNYLGAAASRNASLEV----AVLRDDFRQSPG--NVVVAVGE 181
+ + D G YTCV N LG A +N +EV ++ +DD G V V
Sbjct: 1406 LQILNAQKEDAGQYTCVVTNELGEAV-KNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNS 1464
Query: 182 PAVLEC----VPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLM-MSHTLKSDAGMYVC 236
LEC VPP P++ W KDG + + G+L+ + T SD+G Y+C
Sbjct: 1465 TLTLECESWAVPP-----PTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLC 1519
Query: 237 VASNMAGERE-------------------SAAAEVMVLERPSFLRRPVNQVVLADAPVTF 277
VA+N+AGE + SAA E++ E + + ++ + P
Sbjct: 1520 VATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYL 1579
Query: 278 LCEVKGDPPPRLRWRKEDGELPTGRYE--IRSDHSLWIGHVSAEDEGTYTCVAENSVGRA 335
C+ PPP L W +ED L G ++ L I V AE+ G Y+C A N VG
Sbjct: 1580 YCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGED 1639
Query: 336 EASGSLSVHVPPQLVTQPQDQMAA----PGESVAFQCETKGNPPPAIFWQKEGSQVLLFP 391
L V PP ++ ++ + +V+ QC GNP P I W + G
Sbjct: 1640 WLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLP----- 1694
Query: 392 SQSLQPTGRFSVSPRGQ-LNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLP 450
P+ R V GQ L ++ + DA Y+C A + AGS L ++ +P
Sbjct: 1695 ---FSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ------VP 1745
Query: 451 PVILQGPANQ-TLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIA 509
P I Q T +L SSV LPC V +P P V W KD Q L + F TL +
Sbjct: 1746 PRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLG 1805
Query: 510 NVQEMDMGFYSCVAKSSTG 528
+ D G Y+C A ++ G
Sbjct: 1806 RARLSDSGMYTCEALNAAG 1824
Score = 164 bits (416), Expect = 4e-40
Identities = 130/454 (28%), Positives = 194/454 (42%), Gaps = 24/454 (5%)
Query: 137 DEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEP 196
DEG+YTC A N G + R +L+V V + P N V LEC+ G P P
Sbjct: 668 DEGIYTCAATNLAGES-KREVALKVLV-PPNIEPGPVNKAVLENASVTLECLAS-GVPPP 724
Query: 197 SVSWRKDGARLKEEEG-RITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVL 255
VSW K + G +++ G L + SDAG Y CVASN+AG E + +
Sbjct: 725 DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV 784
Query: 256 ERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL-PTGRYEIR---SDHSL 311
L + VL + PV C G P P L W K+ + P G ++ L
Sbjct: 785 PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVL 844
Query: 312 WIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETK 371
+ A D G Y+CVA ++VG L VH+PP ++ + + ESVA +C++
Sbjct: 845 TLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSH 904
Query: 372 GNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAG 431
PPP + W K+G + P L + + L + DAG+Y C+A++ AG
Sbjct: 905 AMPPPVLSWWKDGRPLEPRPGVHLS-------ADKALLQVDRADVWDAGHYTCEALNQAG 957
Query: 432 SILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWL 491
L + A P L+ T+ G L C G P P + W+KDGQ L
Sbjct: 958 RSEKHYNLNVWVA-----PVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPL 1012
Query: 492 QGD--DLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVS--PD 547
G+ LQ + LY+ Q G Y+C + G ++ L++ ++ +
Sbjct: 1013 PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPRE 1072
Query: 548 PPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQ 581
PPT+ S + K T+TW+ + Q
Sbjct: 1073 PPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ 1106
Score = 164 bits (415), Expect = 5e-40
Identities = 129/468 (27%), Positives = 201/468 (42%), Gaps = 37/468 (7%)
Query: 75 VSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRA 134
+ PA L C P P++ WY+ ++ E +L G + +V A
Sbjct: 1571 IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVS-----VLQGGRVLQIPLVRAENA 1625
Query: 135 RPDEGVYTCVARNYLGAAASRNASLEVA--VLRDDFRQSPGNVVVAVGEPAVLECVPPRG 192
G Y+C A N +G L + V+ D + V V L+C P G
Sbjct: 1626 ----GRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC-PALG 1680
Query: 193 HPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLK-SDAGMYVCVASNMAGERESAAAE 251
+P P++SW ++G + G+++ T + +DA Y+CVA N AG E
Sbjct: 1681 NPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFT- 1739
Query: 252 VMVLERPSFLRRPVNQVV-LADAPVTFLCEVKGDPPPRLRWRKEDGELPTGR--YEIRSD 308
+ V P + QV + ++ V+ C+V P P + W K+ L G + +
Sbjct: 1740 LRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGT 1799
Query: 309 HSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPP---QLVTQPQDQ-MAAPGESV 364
H+L +G D G YTC A N+ GR + LSV VPP Q PQD + G+
Sbjct: 1800 HTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKA 1859
Query: 365 AFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVC 424
CET P P + W K+G ++L G+ +L I Q D G Y C
Sbjct: 1860 VLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ-------RLEIQEAQVSDKGLYSC 1912
Query: 425 QAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTL--VLGSSVWLPCRVTGNPQPSV 482
+ +VAG + L ++ +PP + P +T+ V GS + L C V+G P P+V
Sbjct: 1913 KVSNVAGEAVRTFTLTVQ------VPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPTV 1965
Query: 483 RWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEA 530
W KD ++ + G L ++ +Q G Y+CVA+++ EA
Sbjct: 1966 TWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEA 2013
Score = 155 bits (393), Expect = 2e-37
Identities = 144/485 (29%), Positives = 205/485 (42%), Gaps = 50/485 (10%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVA-----TVREDPRAHRLLL 118
P I P + V TL C A G P P++ W+K V+ TV D R R+
Sbjct: 695 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRI-- 752
Query: 119 PSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQS-PGNVVV 177
+ D G Y CVA N G+ R R S PG V+
Sbjct: 753 ------------EQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVL- 799
Query: 178 AVGEPAVLECVPPRGHPEPSVSWRKDGARLKE--EEGRITIRGGK-LMMSHTLKSDAGMY 234
V P L C G P P++ W KDG + G GG+ L ++ SD+G Y
Sbjct: 800 -VNTPVRLTC-NATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 857
Query: 235 VCVASNMAGE-RESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRK 293
CVA + GE R+ +V + PS L +N V+A+ V C+ PPP L W K
Sbjct: 858 SCVAVSAVGEDRQDVVLQVHM--PPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK 915
Query: 294 EDGEL-PTGRYEIRSDHS-LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVT 351
+ L P + +D + L + D G YTC A N GR+E +L+V V P
Sbjct: 916 DGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPL 975
Query: 352 QPQDQMAA-PGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQ-L 409
+ + G + CE +G P P I W+K+G + P + G VS G+ L
Sbjct: 976 RESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPL---PGEG---AGLQHVSAVGRLL 1029
Query: 410 NITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVIL---QGPANQTLVLGS 466
+ Q G Y C+ +V G+ LE+ +PP I + P ++V
Sbjct: 1030 YLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVH------VPPQIAGPREPPTQVSVVQDG 1083
Query: 467 SVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANG-TLYIANVQEMDMGFYSCVAKS 525
L C TG P P+V W++DGQ + G +L + G +L++ Q G YSCVA++
Sbjct: 1084 VATLECNATGKPPPTVTWERDGQPV-GAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN 1142
Query: 526 STGEA 530
G A
Sbjct: 1143 LAGRA 1147
Score = 155 bits (391), Expect = 3e-37
Identities = 148/478 (30%), Positives = 198/478 (41%), Gaps = 56/478 (11%)
Query: 78 GEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPD 137
G P L C A G P P + W+ G VA E RL L R P
Sbjct: 420 GRPVALECVARGHPSPTLSWHHEGLPVAESNES----RLETDGSVL--------RLESPG 467
Query: 138 E---GVYTCVARNYLGAAASRNASLEVAVLRDDF-RQSPGNVVVAVGEPAVLECVPPRGH 193
E G+Y+CVA + G A + S+EV V + G V VG+P L C G
Sbjct: 468 EASSGLYSCVASSPAGEAVLQY-SVEVQVPPQLLVAEGLGQVTTIVGQPLELPC-QASGS 525
Query: 194 PEPSVSWRKDGARLKEEEG-RITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEV 252
P P++ W ++G +E G ++ +G L + H +G++ C A+N AG +A AEV
Sbjct: 526 PVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG---TAGAEV 582
Query: 253 MVLER----PSFLRRPVNQV-----------VLADAPVTFLCEVKGDPPPRLRWRKED-- 295
V P L P+ Q D PV PP W
Sbjct: 583 EVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSL 642
Query: 296 -GELPTGRYEIRS-DHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQP 353
GE PTG S L I V DEG YTC A N G ++ +L V VPP + P
Sbjct: 643 WGE-PTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGP 701
Query: 354 QDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITA 413
++ SV +C G PPP + W K V + ++ GR L I
Sbjct: 702 VNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV-------LRIEQ 754
Query: 414 VQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCR 473
Q DAG Y C A +VAGS + L + LPP L GP +++ + V L C
Sbjct: 755 AQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPP-SLPGP----VLVNTPVRLTCN 809
Query: 474 VTGNPQPSVRWKKDGQWLQGDDLQFKTMANG--TLYIANVQEMDMGFYSCVAKSSTGE 529
TG P P++ W KDG + + G L +A+ + D G YSCVA S+ GE
Sbjct: 810 ATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGE 867
Score = 154 bits (389), Expect = 6e-37
Identities = 140/514 (27%), Positives = 214/514 (41%), Gaps = 83/514 (16%)
Query: 78 GEPATLPCRAEGRPRPNIEWYKNGARVATVRE-----------DPRAHRLLLPSGALFFP 126
G+ TL C A G P P I W K+ V HRLL +L FP
Sbjct: 111 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFP 170
Query: 127 RIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPG------------- 173
RI GR R G +A A + F Q P
Sbjct: 171 RIQPGRSGRRGAQA---------GGSAQTKAPWXAGLA--GFEQFPTPHAFSPPAPPSVL 219
Query: 174 ------NVVVAVGEPAVLECVPPRGHPEPSVSWRKD-------GARLK-EEEGRITIRGG 219
V+ G L+C G P P V W KD G L+ +E+G++
Sbjct: 220 GAGAAQEVLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVL---- 274
Query: 220 KLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFL--RRPVNQVVLADAPVTF 277
++ SH D G Y CVA + AG+ ++ ++ V P+ V+ D V
Sbjct: 275 RITGSHV--GDEGRYQCVAFSPAGQ-QARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQL 331
Query: 278 LCEVKGDPPPRLRWRKEDGELPTGRYEI--RSDHSLWIGHVSAEDEGTYTCVAENSVGRA 335
LCE +G P P + W K+ LPT + R L +G + D G YTC A N+VG A
Sbjct: 332 LCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAA 391
Query: 336 EASGSLSVHVPPQLV---TQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPS 392
E + L V+VPP + +P A G VA +C +G+P P + W EG V
Sbjct: 392 EKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNE 451
Query: 393 QSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPV 452
L+ G L + + +G Y C A S AG + + +E++ +PP
Sbjct: 452 SRLETDG-------SVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQ------VPPQ 498
Query: 453 IL--QGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMAN--GTLYI 508
+L +G T ++G + LPC+ +G+P P+++W ++G+ ++L +A+ TL+I
Sbjct: 499 LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR--PAEELAGVQVASQGTTLHI 556
Query: 509 ANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDW 542
+V+ G ++C A + G A + + +W
Sbjct: 557 DHVELDHSGLFACQATNEAGTAGAEVEVSVHGEW 590
Score = 147 bits (371), Expect = 7e-35
Identities = 143/490 (29%), Positives = 206/490 (42%), Gaps = 42/490 (8%)
Query: 57 VGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRL 116
V P+ A PR E P + V + ATL C A G+P P + W ++G V
Sbjct: 1063 VPPQIAGPR--EPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGA-----ELGLQ 1115
Query: 117 LLPSGALFFPRIVHGRRARPDE-GVYTCVARNYLGAAASRNASLEVAV---LRDDFRQSP 172
L G + +H RA+ G Y+CVA N G A R L V V L D
Sbjct: 1116 LQNQG-----QSLHVERAQAAHTGRYSCVAENLAGRA-ERKFELSVLVPPELIGDLDPLT 1169
Query: 173 GNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGG-KLMMSHTLKSDA 231
N+ A+ P L C G P P++ W + + E + GG L M+ T + D+
Sbjct: 1170 -NITAALHSPLTLLC-EAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDS 1227
Query: 232 GMYVCVASNMAGE-RESAAAEVMVLERPSFLRRPVNQV--VLADAPVTFLCEVKGDPPPR 288
G+Y C+ASN AGE R + + EV+V PS + +V VL +C V G P P+
Sbjct: 1228 GLYSCLASNEAGEARRNFSVEVLV--PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPK 1285
Query: 289 LRWRKEDGELPTG-RYEIRSDHSLW-IGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVP 346
L W K+ L G + I D L + + G Y+C+A N+VG LSV +
Sbjct: 1286 LTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLA 1345
Query: 347 PQLVTQPQDQM-----AAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRF 401
P ++ +D ++ CE P P I W K+G+ + L P
Sbjct: 1346 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTH- 1404
Query: 402 SVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIK-GASLDGLPPVILQGPANQ 460
L I Q+ DAG Y C + G + +E+ S+ P+ G
Sbjct: 1405 ------GLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEV 1458
Query: 461 TLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLY-IANVQEMDMGFY 519
+ S++ L C P P++RW KDGQ + + + + G L I Q D G Y
Sbjct: 1459 KTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSS-RLQVLGEGRLLQIQPTQVSDSGRY 1517
Query: 520 SCVAKSSTGE 529
CVA + GE
Sbjct: 1518 LCVATNVAGE 1527
Score = 134 bits (336), Expect = 8e-31
Identities = 146/532 (27%), Positives = 209/532 (39%), Gaps = 63/532 (11%)
Query: 42 HTLLPPGDPSLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKN- 100
H PP PS+ G+ E +L G L C G P P +EW K+
Sbjct: 208 HAFSPPAPPSVLGAGAAQE------------VLGLAGADVELQCWTSGVPTPQVEWTKDR 255
Query: 101 -----GARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASR 155
G V+ED + R+ G DEG Y CVA + G A R
Sbjct: 256 QPVLPGGPHLQVQEDGQVLRIT-------------GSHVG-DEGRYQCVAFSPAGQQA-R 300
Query: 156 NASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRIT 215
+ L V + + V + + V RG P P+++W KDGA L +
Sbjct: 301 DFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVY 360
Query: 216 IRGGK-LMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLR---RPVNQVVLA 271
RGG+ L + SDAG+Y C ASN G E A + V P+ RP +A
Sbjct: 361 TRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAVA 419
Query: 272 DAPVTFLCEVKGDPPPRLRWRKEDGELP---TGRYEIRSDHS-LWIGHVSAEDEGTYTCV 327
PV C +G P P L W E LP + + +D S L + G Y+CV
Sbjct: 420 GRPVALECVARGHPSPTLSWHHEG--LPVAESNESRLETDGSVLRLESPGEASSGLYSCV 477
Query: 328 AENSVGRAEASGSLSVHVPPQL-VTQPQDQMAA-PGESVAFQCETKGNPPPAIFWQKEGS 385
A + G A S+ V VPPQL V + Q+ G+ + C+ G+P P I W + G
Sbjct: 478 ASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR 537
Query: 386 QVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGAS 445
P++ L G S L+I V+ +G + CQA + AG+ A+ + + G
Sbjct: 538 -----PAEEL--AGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEW 590
Query: 446 LDGLPPVILQGPANQTLVLGSSVWLPCRVT------GNPQPSV--RWKKDGQ-WLQGDDL 496
G+ V + G + SS C +P+P + W G W + +
Sbjct: 591 APGVLEVPI-GQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGI 649
Query: 497 QFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDP 548
L I V D G Y+C A + GE+ LK+ + P P
Sbjct: 650 PVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGP 701
Score = 128 bits (322), Expect = 3e-29
Identities = 138/490 (28%), Positives = 189/490 (38%), Gaps = 72/490 (14%)
Query: 85 CRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCV 144
C G P+P + W K G + P +L G+LF + + D G Y C
Sbjct: 24 CGTHGTPKPQVTWRK-GPSSEPLHGQPGV--AVLEEGSLFLASV-----SPADSGDYECQ 75
Query: 145 ARNYLGAAASRNASLEVAV---LRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWR 201
A N +G + SR A L V V +R+D R++ NV G+ LEC G P P + W
Sbjct: 76 ATNEVG-STSRRAKLVVYVPPSIREDGRKA--NVSGMAGQSLTLEC-DANGFPVPEIVWL 131
Query: 202 KDGARLKEEEG----------------RITIRGGKLMMSHTLKSDAGMYVCVASNMAGER 245
KD + G R+ G L +G A A +
Sbjct: 132 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTK 191
Query: 246 ESAAAEVMVLER------------PSFLRRPVNQVV--LADAPVTFLCEVKGDPPPRLRW 291
A + E+ PS L Q V LA A V C G P P++ W
Sbjct: 192 APWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEW 251
Query: 292 RKE-DGELPTGRY-EIRSD-HSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQ 348
K+ LP G + +++ D L I DEG Y CVA + G+ L VH PP
Sbjct: 252 TKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT 311
Query: 349 LVTQPQDQMAAPGES--VAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPR 406
+ + A E V CE +G P P I W K+G +L PT V R
Sbjct: 312 IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDG---------ALLPTSTKVVYTR 362
Query: 407 G--QLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVL 464
G QL + Q DAG Y C+A + G+ K LD P ++G + V+
Sbjct: 363 GGRQLQLGRAQSSDAGVYTCKASNAVGA-------AEKATRLDVYVPPTIEGAGGRPYVV 415
Query: 465 ----GSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYS 520
G V L C G+P P++ W +G + + L + + E G YS
Sbjct: 416 KAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYS 475
Query: 521 CVAKSSTGEA 530
CVA S GEA
Sbjct: 476 CVASSPAGEA 485
Score = 36.2 bits (82), Expect = 0.22
Identities = 19/62 (30%), Positives = 29/62 (46%), Gaps = 3/62 (4%)
Query: 472 CRVTGNPQPSVRWKK--DGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGE 529
C G P+P V W+K + L G + G+L++A+V D G Y C A + G
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQP-GVAVLEEGSLFLASVSPADSGDYECQATNEVGS 82
Query: 530 AT 531
+
Sbjct: 83 TS 84
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 215 bits (548), Expect = 2e-55
Identities = 153/475 (32%), Positives = 216/475 (45%), Gaps = 36/475 (7%)
Query: 63 MPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRL-LLPSG 121
+P I PP + VS + A LPC+A+G P P + W K+ V DPR+ R +LP G
Sbjct: 3672 VPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD-----RVPLDPRSPRFEILPEG 3726
Query: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDD-FRQSPGNVVVAVG 180
+L ++ D G Y C+A N +A S ++ VL SP N+ +
Sbjct: 3727 SLRIQPVL-----AQDAGHYLCLASN---SAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 3778
Query: 181 EPAVLECVPPRGHPEPSVSWRKDGARLK---EEEGRITIRGGKLMMSHTLKSDAGMYVCV 237
PA+L C G P+P V W KDG +L ++ + L+++ D+ + CV
Sbjct: 3779 TPALLPC-EASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECV 3837
Query: 238 ASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGE 297
SN GE +V V P+ + V APV C G P P + W K +
Sbjct: 3838 VSNEVGEAHRLY-QVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ 3896
Query: 298 LPT--GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQD 355
L Y + +L IG G YTC A NS G A L+V P + P
Sbjct: 3897 LGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSV 3956
Query: 356 QMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQ 415
A E V CE G P P I WQKEG V S V P GQL I
Sbjct: 3957 VRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST--------QVLPGGQLRIAHAS 4008
Query: 416 RGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVT 475
DAG Y+C A + AGS + K L ++ +PPVI G + + GS +LPC+
Sbjct: 4009 PEDAGNYLCIAKNSAGSAMGKTRLVVQ------VPPVIENGLPDLSTTEGSHAFLPCKAR 4062
Query: 476 GNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEA 530
G+P+P++ W KDGQ + G + +F +G L + N++ D G Y+C A+++ G A
Sbjct: 4063 GSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRA 4117
Score = 212 bits (540), Expect = 2e-54
Identities = 154/488 (31%), Positives = 219/488 (44%), Gaps = 35/488 (7%)
Query: 62 AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSG 121
A P + P + E LPC A G PRP I W K G VAT +LP G
Sbjct: 3946 ASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVAT-----GVSTQVLPGG 4000
Query: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGE 181
L RI H + D G Y C+A+N G+A + V + ++ G
Sbjct: 4001 QL---RIAHA--SPEDAGNYLCIAKNSAGSAMGKTRL--VVQVPPVIENGLPDLSTTEGS 4053
Query: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIR-GGKLMMSHTLKSDAGMYVCVASN 240
A L C RG PEP+++W KDG + EG+ TI+ G+L++ + DAG Y C A N
Sbjct: 4054 HAFLPC-KARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAEN 4112
Query: 241 MAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT 300
G R + +L P F P ++ + + C +G P PR+ W D +
Sbjct: 4113 AVG-RARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTE 4171
Query: 301 GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAP 360
G E +L VS ED GTY C AEN VGR +A + V P L + + P
Sbjct: 4172 GVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEP 4231
Query: 361 -GESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDA 419
G S+ C +G+P P I W K+G L+ + G L I +R DA
Sbjct: 4232 VGGSIQLDCVVRGDPVPDIHWIKDG--------LPLRGSHLRHQLQNGSLTIHRTERDDA 4283
Query: 420 GYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQ 479
G Y C A + G +L ++ A PV P + T+ G V L C+ TG P
Sbjct: 4284 GRYQCLAENEMGVAKKVVILVLQSA------PVFQVEPQDMTVRSGDDVALRCQATGEPT 4337
Query: 480 PSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMR 539
P++ W + GQ L+ + +T+ +G+L++ NV+ D G Y CVA + G AT +L +R
Sbjct: 4338 PTIEWLQAGQPLRA-SRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 4396
Query: 540 ED----WG 543
+ WG
Sbjct: 4397 GEPQGSWG 4404
Score = 194 bits (492), Expect = 6e-49
Identities = 173/604 (28%), Positives = 247/604 (40%), Gaps = 118/604 (19%)
Query: 73 LLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGR 132
+LV+ GE A L C A G P P + WY+ G + E + +L +P+
Sbjct: 707 VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAA----------- 755
Query: 133 RARPDEGVYTCVARNYLGAAASRNASLEVAV-LRDDFRQSPGNVVVAVGEPAVLECVPPR 191
D G YTC A N LG A +A +++AV + P +V V +G A+L C
Sbjct: 756 -QERDAGTYTCRAVNELGDA---SAEIQLAVGHAPQLTELPRDVTVELGRSALLAC-RAT 810
Query: 192 GHPEPSVSWRKD-----GARLKEEEGRITIR--GGKLMMSHTLKSDAGMYVCVASNMAGE 244
G P P+V+WR+ G RL G + + G L D YVC A N+ G+
Sbjct: 811 GRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGK 870
Query: 245 RESAAAEVMVLERPSFLRRPVNQV-VLADAPVTFLCEV-KGDPPPRLRWRKEDGELPTG- 301
++ A ++ P + V VL PV+ C V G P P W K+ LP G
Sbjct: 871 VQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGS 930
Query: 302 RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPG 361
R+ IR+D SL + E G Y+CVA N+ G L V VPP++ + G
Sbjct: 931 RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEG 990
Query: 362 ESVAFQCETKGNPPPAIFWQKEGSQV--------------LLFPSQSLQPTG-------- 399
+ C G P P I W KE + + LL S Q G
Sbjct: 991 VPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATN 1050
Query: 400 ---------RFSVS---------------PRGQLNITAVQRGDAGYYVCQAVSVAGSILA 435
R SV+ P G L + VQ GD+G+Y C A + AGS
Sbjct: 1051 TVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASH 1110
Query: 436 KALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDD 495
+ +L ++ +PP + GP +++G ++ L C GNP+P + W KDG LQG
Sbjct: 1111 RYVLGVQ------VPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRG 1164
Query: 496 LQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMRE--DWG---------- 543
Q G+++ A ++ D G Y C A +S G W L++ E WG
Sbjct: 1165 PQ------GSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLER 1218
Query: 544 VSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNP-------QTGAAVT---SYVIEA 593
V+ + + P G P V TW+ P Q G AV S + +
Sbjct: 1219 VAGENASLPCPARGTPKPQV-----------TWRKGPSSEPLHGQPGVAVLEEGSLFLAS 1267
Query: 594 FSPA 597
SPA
Sbjct: 1268 VSPA 1271
Score = 190 bits (483), Expect = 7e-48
Identities = 169/548 (30%), Positives = 231/548 (42%), Gaps = 58/548 (10%)
Query: 50 PSLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVRE 109
P+ + GP+DA+ LV G+ A L C + P P + WYK+G +
Sbjct: 3029 PAFRQAPRGPQDAV----------LVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL--- 3075
Query: 110 DPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFR 169
A R G R+ D+G+Y+C N G A R +L V V
Sbjct: 3076 ---AQRTQALRGG---QRLEIQEAQVSDKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFEN 3128
Query: 170 QSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGR---ITIRGGKLMMSHT 226
V G P VL C G P P+V+W KD R+ E + RGG+L +S
Sbjct: 3129 PKTETVSQVAGSPLVLTC-DVSGVPAPTVTWLKD--RMPVESSAVHGVVSRGGRLQLSRL 3185
Query: 227 LKSDAGMYVCVASNMAGE-RESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDP 285
+ AG Y CVA N E R+ V+V R VL V CE G P
Sbjct: 3186 QPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQP 3245
Query: 286 PPRLRWRKEDGEL-----PTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGS 340
PP + W K+ L P R+ + SL + + A D G YTCVA N G +
Sbjct: 3246 PPDVAWLKDGSPLGQDMGPHLRFYL-DGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHT 3304
Query: 341 LSVHVPPQLVTQPQD----QMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQ 396
++V VPP + Q D ++ PGE V C +G+PP + W K+G + L L
Sbjct: 3305 VNVLVPP-TIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLH 3363
Query: 397 PTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVI--L 454
+G L I+ VQ DAG + C A S AG L+++ +PPV+ +
Sbjct: 3364 GSGH-------TLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ------VPPVLEPV 3410
Query: 455 QGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEM 514
+ + +V GS V LPC G P P V W KDG+ L L+ +L + V
Sbjct: 3411 EFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLE----QGPSLQLEAVGAG 3466
Query: 515 DMGFYSCVAKSSTGEATWSGWLKMREDWGVSPD-PPTEPSSPPGAPSQPVVTEITKNSIT 573
D G YSCVA S GEA L + E + PTE S PGAP + +
Sbjct: 3467 DSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPN 3526
Query: 574 LTWKPNPQ 581
+TW + Q
Sbjct: 3527 ITWHKDGQ 3534
Score = 189 bits (479), Expect = 2e-47
Identities = 157/483 (32%), Positives = 212/483 (43%), Gaps = 55/483 (11%)
Query: 63 MPRIVEQPPDLLVSR--GEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPS 120
+P E P VS+ G P L C G P P + W K+ V E H ++
Sbjct: 3122 VPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPV----ESSAVHGVVSRG 3177
Query: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVV---V 177
G L R+ + G YTCVA N A VAVL +S G V
Sbjct: 3178 GRLQLSRLQPAQA-----GTYTCVAEN---TQAEARKDFVVAVLVAPRIRSSGVAREHHV 3229
Query: 178 AVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEG---RITIRGGKLMMSHTLKSDAGMY 234
G+ L+C G P P V+W KDG+ L ++ G R + GG L++ SDAG Y
Sbjct: 3230 LEGQEVRLDCEAD-GQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAY 3288
Query: 235 VCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAP---VTFLCEVKGDPPPRLRW 291
CVA N AGE ++ V VL P+ + L P VT +C V+G PP + W
Sbjct: 3289 TCVAHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSW 3347
Query: 292 RKEDGELPTGRYEI--RSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQL 349
K+ LP + + S H+L I V D G +TCVA + G A+ + +L V VPP L
Sbjct: 3348 LKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVL 3407
Query: 350 --VTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRG 407
V D + G V CE +G P P + W K+G +L SQSL+
Sbjct: 3408 EPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLL---SQSLE--------QGP 3456
Query: 408 QLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQG--PANQTLVLG 465
L + AV GD+G Y C AVS AG L + PP I P +L G
Sbjct: 3457 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME------PPHIEDSGQPTELSLTPG 3510
Query: 466 SSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKS 525
+ + L C G PQP++ W KDGQ L + N + ++ D G Y+C+A+S
Sbjct: 3511 APMELLCDAQGTPQPNITWHKDGQAL-------TRLENNSRATRVLRVRDAGLYTCLAES 3563
Query: 526 STG 528
G
Sbjct: 3564 PAG 3566
Score = 181 bits (459), Expect = 4e-45
Identities = 148/493 (30%), Positives = 215/493 (43%), Gaps = 52/493 (10%)
Query: 69 QPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRI 128
QP +L ++ G P L C A+G P+PNI W+K+G + + + RA R+L
Sbjct: 3501 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVL----------- 3549
Query: 129 VHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVV----------VA 178
R R D G+YTC+A + GA S V V Q+P N+V +A
Sbjct: 3550 ----RVR-DAGLYTCLAESPAGAIEK---SFRVRV------QAPPNIVGPRGPRFVVGLA 3595
Query: 179 VGEPAVLECVPPRGHPEPSVSWRKDGARLKEE-EGRITIRGGKLMMSHTLKSDAGMYVCV 237
G+ VLEC P P ++W +DG L+E+ + RG L + +D+G Y C
Sbjct: 3596 PGQ-LVLEC-SVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCT 3653
Query: 238 ASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGE 297
A N AG S A V + P+ P V + C+ G P P + WRK+
Sbjct: 3654 ARNAAGST-SVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVP 3712
Query: 298 LP--TGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQD 355
L + R+EI + SL I V A+D G Y C+A NS G L V PP + P +
Sbjct: 3713 LDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSN 3772
Query: 356 QMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQ 415
CE G+P P + W K+G Q L F Q G + + P L +TA
Sbjct: 3773 LTLTAHTPALLPCEASGSPKPLVVWWKDG-QKLDFRLQQ----GAYRLLPSNALLLTAPG 3827
Query: 416 RGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVT 475
D+ + C + G A L ++ +PP I + T+ + + V L C T
Sbjct: 3828 PQDSAQFECVVSNEVGE--AHRLYQVTVH----VPPTIADDQTDFTVTMMAPVVLTCHST 3881
Query: 476 GNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGW 535
G P P+V W K G L ++ +G L I + G Y+C A++S G A +
Sbjct: 3882 GIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVF 3941
Query: 536 LKMREDWGVSPDP 548
L ++ V P P
Sbjct: 3942 LTVQASPVVKPLP 3954
Score = 177 bits (448), Expect = 8e-44
Identities = 148/532 (27%), Positives = 208/532 (39%), Gaps = 93/532 (17%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDP-RAHRLLLP-SG 121
P++ E P D+ V G A L CRA GRP P + W + + +R R R P SG
Sbjct: 786 PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG 845
Query: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGE 181
LFF + A D+ Y C ARN G + + S V V G+
Sbjct: 846 VLFFESV-----APEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQ 900
Query: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNM 241
P L C+ G P P W KDG L G L + L+ AG Y CVA+N
Sbjct: 901 PVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNT 960
Query: 242 AGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTG 301
AG + E++V P + + P + C G P P + W KE L +
Sbjct: 961 AGSQHRDV-ELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSR 1019
Query: 302 --RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEA---------------------- 337
Y + + +L I SA+D G Y C A N+VG +
Sbjct: 1020 GPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLL 1079
Query: 338 -SGSL------------------------------SVHVPPQLVTQPQDQMAAPGESVAF 366
SGSL V VPPQ+ P+ GE++
Sbjct: 1080 PSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDL 1139
Query: 367 QCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQA 426
C +GNP P + W K+G V+L GR P+G ++ A++ DAG Y C+A
Sbjct: 1140 NCVAEGNPEPQLSWSKDG--VVL--------QGR---GPQGSVHFAAIRTSDAGRYRCEA 1186
Query: 427 VSVAGSILAKALLEIKGASLDGLPPVILQGPANQT-----LVLGSSVWLPCRVTGNPQPS 481
+ AG + L + PP A++T V G + LPC G P+P
Sbjct: 1187 SNSAGVDAWEVELRVLE------PP---HWGADETSGLLERVAGENASLPCPARGTPKPQ 1237
Query: 482 VRWKK--DGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEAT 531
V W+K + L G + G+L++A+V D G Y C A + G +
Sbjct: 1238 VTWRKGPSSEPLHGQP-GVAVLEEGSLFLASVSPADSGDYECQATNEVGSTS 1288
Score = 176 bits (446), Expect = 1e-43
Identities = 151/496 (30%), Positives = 218/496 (43%), Gaps = 44/496 (8%)
Query: 63 MPRIVEQPPD---LLVSR-GEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLL 118
+P ++Q D LVSR GE T+ C G P ++ W K+G + P + R LL
Sbjct: 3309 VPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL------PLSQRTLL 3362
Query: 119 PSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRD-DFRQSPGNVVV 177
G+ RI + A D G++TCVA + G A RN +L+V V + + +VVV
Sbjct: 3363 -HGSGHTLRISKVQLA--DAGIFTCVAASPAGVA-DRNFTLQVQVPPVLEPVEFQNDVVV 3418
Query: 178 AVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCV 237
G L C RG P P VSW KDG L + +G L + D+G Y CV
Sbjct: 3419 VRGSLVELPC-EARGVPLPLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSCV 3474
Query: 238 ASNMAGERESAAAEVMVLERPSF--LRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKED 295
A + AGE ++ V+E P +P + AP+ LC+ +G P P + W K+
Sbjct: 3475 AVSEAGEARRHF-QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG 3533
Query: 296 GELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQD 355
L R+ L + D G YTC+AE+ G E S + V PP +V
Sbjct: 3534 QALTRLENNSRATRVLRV-----RDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGP 3588
Query: 356 QMA---APGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNIT 412
+ APG+ V +C + P P I W ++G + GRF L +
Sbjct: 3589 RFVVGLAPGQLV-LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF-------LQLQ 3640
Query: 413 AVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPC 472
A+ D+G Y C A + AGS +EI P I GP + + + LPC
Sbjct: 3641 ALSTADSGDYSCTARNAAGSTSVAFRVEIHTV------PTIRSGPPAVNVSVNQTALLPC 3694
Query: 473 RVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATW 532
+ G P P V W+KD L +F+ + G+L I V D G Y C+A +S G
Sbjct: 3695 QADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQ 3754
Query: 533 SGWLKMREDWGVSPDP 548
L++ E ++P P
Sbjct: 3755 GRDLRVLEPPAIAPSP 3770
Score = 175 bits (443), Expect = 3e-43
Identities = 140/497 (28%), Positives = 214/497 (43%), Gaps = 48/497 (9%)
Query: 73 LLVSRGEPATLPCRAEGRPRPNIEWYKNGARV----ATVREDPRAHRLLLPSGALFFPRI 128
L V G P +L C G P P I W K+G + A ++ RLL
Sbjct: 2172 LTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYL--------- 2222
Query: 129 VHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDF--RQSPGNVVVAVGEPAVLE 186
G+ EG YTC N +G + S++ LEV V R+ P V V A LE
Sbjct: 2223 --GQAQLAQEGTYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLE 2279
Query: 187 CVPPRGHPEPSVSWRKDGARLKEEEG-RITIRGGKLMMSHTLKSDAGMYVCVASNMAGER 245
C G P P+V+W +DG + E G ++ +G L + + G Y CVA N+AG
Sbjct: 2280 C-NATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 2338
Query: 246 ESAAAEVMVLERPSFLRR--PVNQVVLA-DAPVTFLCEVKGDPPPRLRWRKEDGELPTGR 302
E E+ VL P + P+ + A +P+T LCE G PPP +RW + + + G
Sbjct: 2339 ERKF-ELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGE 2397
Query: 303 --YEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQM--A 358
Y + L + +D G Y+C+A N G A + S+ V VPP + + +++
Sbjct: 2398 DTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKV 2457
Query: 359 APGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGD 418
G++ C G+P P + W K+G + + + P G L +
Sbjct: 2458 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVL-------LQVLQANLSS 2510
Query: 419 AGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQ-----TLVLGSSVWLPCR 473
AG+Y C A + G L + L P IL G + T+ + + + L C
Sbjct: 2511 AGHYSCIAANAVGEKTKHFQLSVL------LAPTILGGAEDSADEEVTVTVNNPISLICE 2564
Query: 474 VTGNPQPSVRWKKDGQWLQGD-DLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATW 532
P P++ W KDG + ++Q +G L I N Q+ D G Y+CV + GEA
Sbjct: 2565 ALAFPSPNITWMKDGAPFEASRNIQLLPGTHG-LQILNAQKEDAGQYTCVVTNELGEAVK 2623
Query: 533 SGWLKMREDWGVSPDPP 549
+ +++ +S D P
Sbjct: 2624 NYHVEVLIPPSISKDDP 2640
Score = 170 bits (431), Expect = 8e-42
Identities = 143/498 (28%), Positives = 218/498 (43%), Gaps = 64/498 (12%)
Query: 78 GEPATLPCRAEGRPRPNIEWYKNGARVATVRE-----------DPRAHRLLLPSGALFFP 126
G+ TL C A G P P I W K+ V HRLL +L FP
Sbjct: 1315 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFP 1374
Query: 127 RIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPG---NVVVAVGEPA 183
RI G D G+Y+C A N G A + VL G V+ G
Sbjct: 1375 RIQEG-----DSGLYSCRAENQAGTA---QRDFHLLVLTPPSVLGAGAAQEVLGLAGADV 1426
Query: 184 VLECVPPRGHPEPSVSWRKD-------GARLK-EEEGRITIRGGKLMMSHTLKSDAGMYV 235
L+C G P P V W KD G L+ +E+G++ ++ SH D G Y
Sbjct: 1427 ELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVL----RITGSHV--GDEGRYQ 1479
Query: 236 CVASNMAGERESAAAEVMVLERPSFL--RRPVNQVVLADAPVTFLCEVKGDPPPRLRWRK 293
CVA + AG+ ++ ++ V P+ V+ D V LCE +G P P + W K
Sbjct: 1480 CVAFSPAGQ-QARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFK 1538
Query: 294 EDGELPTGRYEI--RSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLV- 350
+ LPT + R L +G + D G YTC A N+VG AE + L V+VPP +
Sbjct: 1539 DGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEG 1598
Query: 351 --TQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQ 408
+P A G VA +C +G+P P + W EG V L+ G
Sbjct: 1599 AGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDG-------SV 1651
Query: 409 LNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVIL--QGPANQTLVLGS 466
L + + +G Y C A S AG + + +E++ +PP +L +G T ++G
Sbjct: 1652 LRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQ------VPPQLLVAEGLGQVTTIVGQ 1705
Query: 467 SVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMAN--GTLYIANVQEMDMGFYSCVAK 524
+ LPC+ +G+P P+++W ++G+ ++L +A+ TL+I +V+ G ++C A
Sbjct: 1706 PLELPCQASGSPVPTIQWLQNGR--PAEELAGVQVASQGTTLHIDHVELDHSGLFACQAT 1763
Query: 525 SSTGEATWSGWLKMREDW 542
+ G A + + +W
Sbjct: 1764 NEAGTAGAEVEVSVHGEW 1781
Score = 169 bits (429), Expect = 1e-41
Identities = 184/655 (28%), Positives = 267/655 (40%), Gaps = 79/655 (12%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
P I+ + ++ V E L C++ P P + W+K+G + +PR L AL
Sbjct: 2071 PSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPL-----EPRPGVHLSADKAL 2125
Query: 124 FFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPA 183
+ R D G YTC A N G + ++ +L V V + + V G P
Sbjct: 2126 ----LQVDRADVWDAGHYTCEALNQAGHS-EKHYNLNVWVAPVFPLRESHTLTVREGHPT 2180
Query: 184 VLECVPPRGHPEPSVSWRKDGARLKEEEG---RITIRGGKLMMSHTLKSDAGMYVCVASN 240
L C RG P P +SWRKDG L E ++ G L + + G Y C SN
Sbjct: 2181 SLSC-ECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN 2239
Query: 241 MAGER-ESAAAEVMVLERPSFLRRPVNQV-VLADAPVTFLCEVKGDPPPRLRWRKEDGEL 298
+ G + EV V + + R P QV V+ D T C G PPP + W + DG+
Sbjct: 2240 VVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWER-DGQ- 2297
Query: 299 PTGR---YEIRSD-HSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLV--TQ 352
P G ++++ SL + A G Y+CVAEN GRAE LSV VPP+L+
Sbjct: 2298 PVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLD 2357
Query: 353 PQDQMAAPGES-VAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNI 411
P + A S + CE G PPPAI W + V P + + ++ L +
Sbjct: 2358 PLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVS--PGEDT-----YLLAGGWMLKM 2410
Query: 412 TAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVL--GSSVW 469
T Q D+G Y C A + AG +E+ +PP I + + + G +
Sbjct: 2411 TQTQEQDSGLYSCLASNEAGEARRNFSVEVL------VPPSIENEDLEEVIKVLDGQTAH 2464
Query: 470 LPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGE 529
L C VTG+PQP + W KDG+ L D + L + G YSC+A ++ GE
Sbjct: 2465 LMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGE 2524
Query: 530 ATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSY 589
T L V P + A + VT N I+L
Sbjct: 2525 KTKHFQL------SVLLAPTILGGAEDSADEEVTVT--VNNPISL--------------- 2561
Query: 590 VIEAFS-PAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRA----VGAWGLSEPSPVS 644
+ EA + P+ TW + DG E L P T L ++ A G + + +
Sbjct: 2562 ICEALAFPSPNITW--MKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 2619
Query: 645 EPVRTQDSS----PSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGP 695
E V+ PS +DP G+ G+ EV ++ + L SW V P
Sbjct: 2620 EAVKNYHVEVLIPPSISKDDP-LGEVGVKEVKTKVNSTLTLECE----SWAVPPP 2669
Score = 168 bits (425), Expect = 4e-41
Identities = 149/499 (29%), Positives = 211/499 (42%), Gaps = 75/499 (15%)
Query: 72 DLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHG 131
++ V+ P +L C A P PNI W K+GA R LLP HG
Sbjct: 2550 EVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQ-----LLPG--------THG 2596
Query: 132 RRA----RPDEGVYTCVARNYLGAAASRNASLEV----AVLRDDFRQSPG--NVVVAVGE 181
+ + D G YTCV N LG A +N +EV ++ +DD G V V
Sbjct: 2597 LQILNAQKEDAGQYTCVVTNELGEAV-KNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNS 2655
Query: 182 PAVLEC----VPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLM-MSHTLKSDAGMYVC 236
LEC VPP P++ W KDG + + G+L+ + T SD+G Y+C
Sbjct: 2656 TLTLECESWAVPP-----PTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLC 2710
Query: 237 VASNMAGERE-------------------SAAAEVMVLERPSFLRRPVNQVVLADAPVTF 277
VA+N+AGE + SAA E++ E + + ++ + P
Sbjct: 2711 VATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYL 2770
Query: 278 LCEVKGDPPPRLRWRKEDGELPTGRYE--IRSDHSLWIGHVSAEDEGTYTCVAENSVGRA 335
C+ PPP L W +ED L G ++ L I V AE+ G Y+C A N VG
Sbjct: 2771 YCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGED 2830
Query: 336 EASGSLSVHVPPQLVTQPQDQMAA----PGESVAFQCETKGNPPPAIFWQKEGSQVLLFP 391
L V PP ++ ++ + +V+ QC GNP P I W + G
Sbjct: 2831 WLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLP----- 2885
Query: 392 SQSLQPTGRFSVSPRGQ-LNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLP 450
P+ R V GQ L ++ + DA Y+C A + AGS L ++ +P
Sbjct: 2886 ---FSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ------VP 2936
Query: 451 PVILQGPANQ-TLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIA 509
P I Q T +L SSV LPC V +P P V W KD Q L + F TL +
Sbjct: 2937 PRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLG 2996
Query: 510 NVQEMDMGFYSCVAKSSTG 528
+ D G Y+C A ++ G
Sbjct: 2997 RARLSDSGMYTCEALNAAG 3015
Score = 164 bits (416), Expect = 4e-40
Identities = 130/454 (28%), Positives = 194/454 (42%), Gaps = 24/454 (5%)
Query: 137 DEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEP 196
DEG+YTC A N G + R +L+V V + P N V LEC+ G P P
Sbjct: 1859 DEGIYTCAATNLAGES-KREVALKVLV-PPNIEPGPVNKAVLENASVTLECLAS-GVPPP 1915
Query: 197 SVSWRKDGARLKEEEG-RITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVL 255
VSW K + G +++ G L + SDAG Y CVASN+AG E + +
Sbjct: 1916 DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV 1975
Query: 256 ERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL-PTGRYEIR---SDHSL 311
L + VL + PV C G P P L W K+ + P G ++ L
Sbjct: 1976 PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVL 2035
Query: 312 WIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETK 371
+ A D G Y+CVA ++VG L VH+PP ++ + + ESVA +C++
Sbjct: 2036 TLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSH 2095
Query: 372 GNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAG 431
PPP + W K+G + P L + + L + DAG+Y C+A++ AG
Sbjct: 2096 AMPPPVLSWWKDGRPLEPRPGVHLS-------ADKALLQVDRADVWDAGHYTCEALNQAG 2148
Query: 432 SILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWL 491
L + A P L+ T+ G L C G P P + W+KDGQ L
Sbjct: 2149 HSEKHYNLNVWVA-----PVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPL 2203
Query: 492 QGD--DLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVS--PD 547
G+ LQ + LY+ Q G Y+C + G ++ L++ ++ +
Sbjct: 2204 PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPRE 2263
Query: 548 PPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQ 581
PPT+ S + K T+TW+ + Q
Sbjct: 2264 PPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ 2297
Score = 164 bits (415), Expect = 5e-40
Identities = 129/468 (27%), Positives = 201/468 (42%), Gaps = 37/468 (7%)
Query: 75 VSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRA 134
+ PA L C P P++ WY+ ++ E +L G + +V A
Sbjct: 2762 IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVS-----VLQGGRVLQIPLVRAENA 2816
Query: 135 RPDEGVYTCVARNYLGAAASRNASLEVA--VLRDDFRQSPGNVVVAVGEPAVLECVPPRG 192
G Y+C A N +G L + V+ D + V V L+C P G
Sbjct: 2817 ----GRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC-PALG 2871
Query: 193 HPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLK-SDAGMYVCVASNMAGERESAAAE 251
+P P++SW ++G + G+++ T + +DA Y+CVA N AG E
Sbjct: 2872 NPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFT- 2930
Query: 252 VMVLERPSFLRRPVNQVV-LADAPVTFLCEVKGDPPPRLRWRKEDGELPTGR--YEIRSD 308
+ V P + QV + ++ V+ C+V P P + W K+ L G + +
Sbjct: 2931 LRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGT 2990
Query: 309 HSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPP---QLVTQPQDQ-MAAPGESV 364
H+L +G D G YTC A N+ GR + LSV VPP Q PQD + G+
Sbjct: 2991 HTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKA 3050
Query: 365 AFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVC 424
CET P P + W K+G ++L G+ +L I Q D G Y C
Sbjct: 3051 VLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ-------RLEIQEAQVSDKGLYSC 3103
Query: 425 QAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTL--VLGSSVWLPCRVTGNPQPSV 482
+ +VAG + L ++ +PP + P +T+ V GS + L C V+G P P+V
Sbjct: 3104 KVSNVAGEAVRTFTLTVQ------VPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPTV 3156
Query: 483 RWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEA 530
W KD ++ + G L ++ +Q G Y+CVA+++ EA
Sbjct: 3157 TWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEA 3204
Score = 162 bits (411), Expect = 2e-39
Identities = 123/407 (30%), Positives = 182/407 (44%), Gaps = 30/407 (7%)
Query: 132 RRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPG-NVVVAVGEPAVLECVPP 190
R ++ +EG Y C A + A + A ++ V + P NV V+ GE AVL C
Sbjct: 485 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSC-RV 540
Query: 191 RGHPEPSVSWRKDGARLKEEEGRIT-IRGGKLMMSHTLKSDAGMYVCVASNMAGERESAA 249
G +++W +D L GR+ + L +S + +D G Y CVASN G A+
Sbjct: 541 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR-AS 599
Query: 250 AEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT-GRYEIRSD 308
++V E P +Q V C G P P + W +E L R + +
Sbjct: 600 VWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 659
Query: 309 HSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQC 368
+L I V+ ED G Y+C A N VG + + +L PP + + A GE C
Sbjct: 660 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 719
Query: 369 ETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVS 428
E G PPP + W + G +++L P S G+L I A Q DAG Y C+AV+
Sbjct: 720 EASGVPPPRVIWYRGGLEMILAPEG----------SSSGKLRIPAAQERDAGTYTCRAVN 769
Query: 429 VAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKK-D 487
G A+ L + G P + + P + T+ LG S L CR TG P P+V W++ D
Sbjct: 770 ELGDASAEIQLAV------GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGD 823
Query: 488 GQWL-----QGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGE 529
GQ L G + + +G L+ +V D Y C A++ G+
Sbjct: 824 GQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGK 870
Score = 158 bits (400), Expect = 3e-38
Identities = 156/533 (29%), Positives = 217/533 (40%), Gaps = 87/533 (16%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKN----------------------- 100
PRI + + G PA+LPC A G P P I W K
Sbjct: 976 PRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQ 1035
Query: 101 ------GARVATVREDP---------RAHRL-----------LLPSGALFFPRIVHGRRA 134
GA V T +RL LLPSG+L ++ G
Sbjct: 1036 PSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVG--- 1092
Query: 135 RPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHP 194
D G Y C A N G+A+ R L V V + P + V VGE L CV G+P
Sbjct: 1093 --DSGHYECTASNPAGSASHRYV-LGVQV-PPQVQPGPRVLKVLVGEALDLNCVA-EGNP 1147
Query: 195 EPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMV 254
EP +SW KDG L+ + G + + SDAG Y C ASN AG ++ E+ V
Sbjct: 1148 EPQLSWSKDGVVLQGRGPQ-----GSVHFAAIRTSDAGRYRCEASNSAGV-DAWEVELRV 1201
Query: 255 LERPSFLRRPVNQVV--LADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYE---IRSDH 309
LE P + + ++ +A + C +G P P++ WRK P + +
Sbjct: 1202 LEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEG 1261
Query: 310 SLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVT--QPQDQMAAPGESVAFQ 367
SL++ VS D G Y C A N VG L V+VPP + + + G+S+ +
Sbjct: 1262 SLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLE 1321
Query: 368 CETKGNPPPAIFWQKEGSQVLLFP--------SQSLQPTGRFSVSPRGQ-LNITAVQRGD 418
C+ G P P I W K+ +Q++ P G + GQ L+ +Q GD
Sbjct: 1322 CDANGFPVPEIVWLKD-AQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGD 1380
Query: 419 AGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVL-GSSVWLPCRVTGN 477
+G Y C+A + AG+ L + P V+ G A + L L G+ V L C +G
Sbjct: 1381 SGLYSCRAENQAGTAQRDFHLLVLTP-----PSVLGAGAAQEVLGLAGADVELQCWTSGV 1435
Query: 478 PQPSVRWKKDGQWLQGDDLQFKTMANG-TLYIANVQEMDMGFYSCVAKSSTGE 529
P P V W KD Q + + +G L I D G Y CVA S G+
Sbjct: 1436 PTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQ 1488
Score = 156 bits (394), Expect = 1e-37
Identities = 146/485 (30%), Positives = 203/485 (41%), Gaps = 54/485 (11%)
Query: 61 DAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNG--ARVATVREDPRAHRLLL 118
D P++V P ++ VS GE A L CR G N+ W ++ +T R A L
Sbjct: 515 DPPPQLVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLE 573
Query: 119 PSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSP------ 172
SG + D G Y CVA N G AS+ + V R++P
Sbjct: 574 ISGII-----------PTDGGRYQCVASNANGVT---RASVWLLV-----REAPQVSIHT 614
Query: 173 GNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAG 232
+ + G + C G+P P +SW ++ L+E+ G L++ DAG
Sbjct: 615 SSQHFSQGVEVKVSC-SASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAG 673
Query: 233 MYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVL--ADAPVTFLCEVKGDPPPRLR 290
Y C A+N G + + + PS VN VVL +CE G PPPR+
Sbjct: 674 NYSCQATNEVG-TDQETVTLYYTDPPSV--SAVNAVVLVAVGEEAVLVCEASGVPPPRVI 730
Query: 291 WRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLV 350
W + E+ E S L I D GTYTC A N +G A A L+V PQL
Sbjct: 731 WYRGGLEMILAP-EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLT 789
Query: 351 TQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLF------PSQSLQPTGRFSVS 404
P+D G S C G PPP + W++ Q L S+S QP
Sbjct: 790 ELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS----- 844
Query: 405 PRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVL 464
G L +V D YVC+A +V G + A+A L + G + PP I ++
Sbjct: 845 --GVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHA----PPQIASSAPTVRVLE 898
Query: 465 GSSVWLPCRV-TGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVA 523
G V LPC V G P P W KDG+ L + A+G+L++ + G YSCVA
Sbjct: 899 GQPVSLPCIVLAGRPLPERHWLKDGRPLPPGS-RHSIRADGSLHLDRALQEHAGRYSCVA 957
Query: 524 KSSTG 528
++ G
Sbjct: 958 TNTAG 962
Score = 155 bits (391), Expect = 3e-37
Identities = 148/478 (30%), Positives = 198/478 (41%), Gaps = 56/478 (11%)
Query: 78 GEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPD 137
G P L C A G P P + W+ G VA E RL L R P
Sbjct: 1611 GRPVALECVARGHPSPTLSWHHEGLPVAESNES----RLETDGSVL--------RLESPG 1658
Query: 138 E---GVYTCVARNYLGAAASRNASLEVAVLRDDF-RQSPGNVVVAVGEPAVLECVPPRGH 193
E G+Y+CVA + G A + S+EV V + G V VG+P L C G
Sbjct: 1659 EASSGLYSCVASSPAGEAVLQY-SVEVQVPPQLLVAEGLGQVTTIVGQPLELPC-QASGS 1716
Query: 194 PEPSVSWRKDGARLKEEEG-RITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEV 252
P P++ W ++G +E G ++ +G L + H +G++ C A+N AG +A AEV
Sbjct: 1717 PVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG---TAGAEV 1773
Query: 253 MVLER----PSFLRRPVNQV-----------VLADAPVTFLCEVKGDPPPRLRWRKED-- 295
V P L P+ Q D PV PP W
Sbjct: 1774 EVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSL 1833
Query: 296 -GELPTGRYEIRS-DHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQP 353
GE PTG S L I V DEG YTC A N G ++ +L V VPP + P
Sbjct: 1834 WGE-PTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGP 1892
Query: 354 QDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITA 413
++ SV +C G PPP + W K V + ++ GR L I
Sbjct: 1893 VNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV-------LRIEQ 1945
Query: 414 VQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCR 473
Q DAG Y C A +VAGS + L + LPP L GP +++ + V L C
Sbjct: 1946 AQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPP-SLPGP----VLVNTPVRLTCN 2000
Query: 474 VTGNPQPSVRWKKDGQWLQGDDLQFKTMANG--TLYIANVQEMDMGFYSCVAKSSTGE 529
TG P P++ W KDG + + G L +A+ + D G YSCVA S+ GE
Sbjct: 2001 ATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGE 2058
Score = 154 bits (388), Expect = 7e-37
Identities = 143/485 (29%), Positives = 204/485 (42%), Gaps = 50/485 (10%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVA-----TVREDPRAHRLLL 118
P I P + V TL C A G P P++ W+K V+ TV D R R+
Sbjct: 1886 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRI-- 1943
Query: 119 PSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQS-PGNVVV 177
+ D G Y CVA N G+ R R S PG V+
Sbjct: 1944 ------------EQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVL- 1990
Query: 178 AVGEPAVLECVPPRGHPEPSVSWRKDGARLKE--EEGRITIRGGK-LMMSHTLKSDAGMY 234
V P L C G P P++ W KDG + G GG+ L ++ SD+G Y
Sbjct: 1991 -VNTPVRLTC-NATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 2048
Query: 235 VCVASNMAGE-RESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRK 293
CVA + GE R+ +V + PS L +N V+A+ V C+ PPP L W K
Sbjct: 2049 SCVAVSAVGEDRQDVVLQVHM--PPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK 2106
Query: 294 EDGEL-PTGRYEIRSDHS-LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVT 351
+ L P + +D + L + D G YTC A N G +E +L+V V P
Sbjct: 2107 DGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPL 2166
Query: 352 QPQDQMAA-PGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQ-L 409
+ + G + CE +G P P I W+K+G + P + G VS G+ L
Sbjct: 2167 RESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPL---PGEG---AGLQHVSAVGRLL 2220
Query: 410 NITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVIL---QGPANQTLVLGS 466
+ Q G Y C+ +V G+ LE+ +PP I + P ++V
Sbjct: 2221 YLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVH------VPPQIAGPREPPTQVSVVQDG 2274
Query: 467 SVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANG-TLYIANVQEMDMGFYSCVAKS 525
L C TG P P+V W++DGQ + G +L + G +L++ Q G YSCVA++
Sbjct: 2275 VATLECNATGKPPPTVTWERDGQPV-GAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN 2333
Query: 526 STGEA 530
G A
Sbjct: 2334 LAGRA 2338
Score = 147 bits (371), Expect = 7e-35
Identities = 143/490 (29%), Positives = 206/490 (42%), Gaps = 42/490 (8%)
Query: 57 VGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRL 116
V P+ A PR E P + V + ATL C A G+P P + W ++G V
Sbjct: 2254 VPPQIAGPR--EPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGA-----ELGLQ 2306
Query: 117 LLPSGALFFPRIVHGRRARPDE-GVYTCVARNYLGAAASRNASLEVAV---LRDDFRQSP 172
L G + +H RA+ G Y+CVA N G A R L V V L D
Sbjct: 2307 LQNQG-----QSLHVERAQAAHTGRYSCVAENLAGRA-ERKFELSVLVPPELIGDLDPLT 2360
Query: 173 GNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGG-KLMMSHTLKSDA 231
N+ A+ P L C G P P++ W + + E + GG L M+ T + D+
Sbjct: 2361 -NITAALHSPLTLLC-EAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDS 2418
Query: 232 GMYVCVASNMAGE-RESAAAEVMVLERPSFLRRPVNQV--VLADAPVTFLCEVKGDPPPR 288
G+Y C+ASN AGE R + + EV+V PS + +V VL +C V G P P+
Sbjct: 2419 GLYSCLASNEAGEARRNFSVEVLV--PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPK 2476
Query: 289 LRWRKEDGELPTG-RYEIRSDHSLW-IGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVP 346
L W K+ L G + I D L + + G Y+C+A N+VG LSV +
Sbjct: 2477 LTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLA 2536
Query: 347 PQLVTQPQDQM-----AAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRF 401
P ++ +D ++ CE P P I W K+G+ + L P
Sbjct: 2537 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTH- 2595
Query: 402 SVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIK-GASLDGLPPVILQGPANQ 460
L I Q+ DAG Y C + G + +E+ S+ P+ G
Sbjct: 2596 ------GLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEV 2649
Query: 461 TLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLY-IANVQEMDMGFY 519
+ S++ L C P P++RW KDGQ + + + + G L I Q D G Y
Sbjct: 2650 KTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSS-RLQVLGEGRLLQIQPTQVSDSGRY 2708
Query: 520 SCVAKSSTGE 529
CVA + GE
Sbjct: 2709 LCVATNVAGE 2718
Score = 129 bits (324), Expect = 2e-29
Identities = 139/502 (27%), Positives = 201/502 (40%), Gaps = 51/502 (10%)
Query: 72 DLLVSRGEPATLPCRAEGRPRPNIEWYKN------GARVATVREDPRAHRLLLPSGALFF 125
++L G L C G P P +EW K+ G V+ED + R+
Sbjct: 1417 EVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRIT-------- 1468
Query: 126 PRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVL 185
G DEG Y CVA + G A R+ L V + + V + + V
Sbjct: 1469 -----GSHVG-DEGRYQCVAFSPAGQQA-RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQ 1521
Query: 186 ECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGK-LMMSHTLKSDAGMYVCVASNMAGE 244
RG P P+++W KDGA L + RGG+ L + SDAG+Y C ASN G
Sbjct: 1522 LLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA 1581
Query: 245 RESAAAEVMVLERPSFLR---RPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELP-- 299
E A + V P+ RP +A PV C +G P P L W E LP
Sbjct: 1582 AEKAT-RLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEG--LPVA 1638
Query: 300 -TGRYEIRSDHS-LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQL-VTQPQDQ 356
+ + +D S L + G Y+CVA + G A S+ V VPPQL V + Q
Sbjct: 1639 ESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQ 1698
Query: 357 MAA-PGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQ 415
+ G+ + C+ G+P P I W + G P++ L G S L+I V+
Sbjct: 1699 VTTIVGQPLELPCQASGSPVPTIQWLQNGR-----PAEEL--AGVQVASQGTTLHIDHVE 1751
Query: 416 RGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVT 475
+G + CQA + AG+ A+ + + G G+ V + G + SS C
Sbjct: 1752 LDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPI-GQYHWGXEHHSSFPAACDPP 1810
Query: 476 ------GNPQPSV--RWKKDGQ-WLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSS 526
+P+P + W G W + + L I V D G Y+C A +
Sbjct: 1811 VHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNL 1870
Query: 527 TGEATWSGWLKMREDWGVSPDP 548
GE+ LK+ + P P
Sbjct: 1871 AGESKREVALKVLVPPNIEPGP 1892
Score = 124 bits (312), Expect = 5e-28
Identities = 103/333 (30%), Positives = 138/333 (41%), Gaps = 20/333 (6%)
Query: 201 RKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSF 260
R+ ARL EE + K++ G Y C A + AG A A+++V + P
Sbjct: 461 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGR-AKAQIVVTDPPPQ 519
Query: 261 LRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELP--TGRYEIRSDHSLWIGHVSA 318
L N V C V G+ P L W ++ LP TGR +D SL I +
Sbjct: 520 LVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIP 579
Query: 319 EDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAI 378
D G Y CVA N+ G AS L V PQ+ Q + G V C G P P I
Sbjct: 580 TDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI 639
Query: 379 FWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKAL 438
W +E SQ+LQ R V +G L I V DAG Y CQA + G+
Sbjct: 640 SWSRE--------SQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVT 691
Query: 439 LEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQF 498
L PP + A + +G L C +G P P V W + G + L
Sbjct: 692 LYYTD------PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMI---LAP 742
Query: 499 KTMANGTLYIANVQEMDMGFYSCVAKSSTGEAT 531
+ ++G L I QE D G Y+C A + G+A+
Sbjct: 743 EGSSSGKLRIPAAQERDAGTYTCRAVNELGDAS 775
Score = 99.0 bits (245), Expect = 3e-20
Identities = 77/257 (29%), Positives = 111/257 (43%), Gaps = 17/257 (6%)
Query: 274 PVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDHSLW-IGHVSAEDEGTYTCVAENSV 332
P+ C V P RL+ R+ + L R+ S +S W I S +EGTY C A +
Sbjct: 443 PLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRA 502
Query: 333 GRAEASGSLSV-HVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFP 391
G A + V PPQLV P + +PGE+ C G P + W ++ + P
Sbjct: 503 GTGRAKAQIVVTDPPPQLVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWVRDWR---VLP 558
Query: 392 SQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPP 451
+ TGR + L I+ + D G Y C A + G A L ++ A P
Sbjct: 559 AS----TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREA------P 608
Query: 452 VILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANV 511
+ ++Q G V + C +G P P + W ++ Q LQ +D + A GTL I V
Sbjct: 609 QVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ-EDSRIHVDAQGTLIIQGV 667
Query: 512 QEMDMGFYSCVAKSSTG 528
D G YSC A + G
Sbjct: 668 APEDAGNYSCQATNEVG 684
Score = 62.4 bits (150), Expect = 3e-09
Identities = 43/140 (30%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 401 FSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQ 460
F S I + + G Y C AVS AG+ AKA + + PP ++ P N
Sbjct: 473 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDP-----PPQLVPAP-NV 526
Query: 461 TLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYS 520
T+ G + L CRV G ++ W +D + L + +A+ +L I+ + D G Y
Sbjct: 527 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 586
Query: 521 CVAKSSTGEATWSGWLKMRE 540
CVA ++ G S WL +RE
Sbjct: 587 CVASNANGVTRASVWLLVRE 606
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 215 bits (548), Expect = 2e-55
Identities = 153/475 (32%), Positives = 216/475 (45%), Gaps = 36/475 (7%)
Query: 63 MPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRL-LLPSG 121
+P I PP + VS + A LPC+A+G P P + W K+ V DPR+ R +LP G
Sbjct: 2390 VPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD-----RVPLDPRSPRFEILPEG 2444
Query: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDD-FRQSPGNVVVAVG 180
+L ++ D G Y C+A N +A S ++ VL SP N+ +
Sbjct: 2445 SLRIQPVL-----AQDAGHYLCLASN---SAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 2496
Query: 181 EPAVLECVPPRGHPEPSVSWRKDGARLK---EEEGRITIRGGKLMMSHTLKSDAGMYVCV 237
PA+L C G P+P V W KDG +L ++ + L+++ D+ + CV
Sbjct: 2497 TPALLPC-EASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECV 2555
Query: 238 ASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGE 297
SN GE +V V P+ + V APV C G P P + W K +
Sbjct: 2556 VSNEVGEAHRLY-QVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ 2614
Query: 298 LPT--GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQD 355
L Y + +L IG G YTC A NS G A L+V P + P
Sbjct: 2615 LGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSV 2674
Query: 356 QMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQ 415
A E V CE G P P I WQKEG V S V P GQL I
Sbjct: 2675 VRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST--------QVLPGGQLRIAHAS 2726
Query: 416 RGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVT 475
DAG Y+C A + AGS + K L ++ +PPVI G + + GS +LPC+
Sbjct: 2727 PEDAGNYLCIAKNSAGSAMGKTRLVVQ------VPPVIENGLPDLSTTEGSHAFLPCKAR 2780
Query: 476 GNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEA 530
G+P+P++ W KDGQ + G + +F +G L + N++ D G Y+C A+++ G A
Sbjct: 2781 GSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRA 2835
Score = 213 bits (541), Expect = 1e-54
Identities = 154/488 (31%), Positives = 219/488 (44%), Gaps = 35/488 (7%)
Query: 62 AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSG 121
A P + P + E LPC A G PRP I W K G VAT +LP G
Sbjct: 2664 ASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVAT-----GVSTQVLPGG 2718
Query: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGE 181
L RI H + D G Y C+A+N G+A + V + ++ G
Sbjct: 2719 QL---RIAHA--SPEDAGNYLCIAKNSAGSAMGKTRL--VVQVPPVIENGLPDLSTTEGS 2771
Query: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIR-GGKLMMSHTLKSDAGMYVCVASN 240
A L C RG PEP+++W KDG + EG+ TI+ G+L++ + DAG Y C A N
Sbjct: 2772 HAFLPC-KARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAEN 2830
Query: 241 MAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT 300
G R + +L P F P ++ + + C +G P PR+ W D +
Sbjct: 2831 AVG-RARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTE 2889
Query: 301 GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAP 360
G E +L VS ED GTY C AEN VGR +A + V P L + + P
Sbjct: 2890 GVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEP 2949
Query: 361 -GESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDA 419
G S+ C +G+P P I W K+G L+ + G L I +R DA
Sbjct: 2950 VGGSIQLDCVVRGDPVPDIHWIKDG--------LPLRGSHLRHQLQNGSLTIRRTERDDA 3001
Query: 420 GYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQ 479
G Y C A + G +L ++ A PV P + T+ G V L C+ TG P
Sbjct: 3002 GRYQCLAENEMGVAKKVVILVLQSA------PVFQVEPQDMTVRSGDDVALRCQATGEPT 3055
Query: 480 PSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMR 539
P++ W + GQ L+ + +T+ +G+L++ NV+ D G Y CVA + G AT +L +R
Sbjct: 3056 PTIEWLQAGQPLRA-SRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3114
Query: 540 ED----WG 543
+ WG
Sbjct: 3115 GEPQGSWG 3122
Score = 190 bits (483), Expect = 7e-48
Identities = 169/548 (30%), Positives = 231/548 (42%), Gaps = 58/548 (10%)
Query: 50 PSLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVRE 109
P+ + GP+DA+ LV G+ A L C + P P + WYK+G +
Sbjct: 1747 PAFRQAPRGPQDAV----------LVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL--- 1793
Query: 110 DPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFR 169
A R G R+ D+G+Y+C N G A R +L V V
Sbjct: 1794 ---AQRTQALRGG---QRLEIQEAQVSDKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFEN 1846
Query: 170 QSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGR---ITIRGGKLMMSHT 226
V G P VL C G P P+V+W KD R+ E + RGG+L +S
Sbjct: 1847 PKTETVSQVAGSPLVLTC-DVSGVPAPTVTWLKD--RMPVESSAVHGVVSRGGRLQLSRL 1903
Query: 227 LKSDAGMYVCVASNMAGE-RESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDP 285
+ AG Y CVA N E R+ V+V R VL V CE G P
Sbjct: 1904 QPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQP 1963
Query: 286 PPRLRWRKEDGEL-----PTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGS 340
PP + W K+ L P R+ + SL + + A D G YTCVA N G +
Sbjct: 1964 PPDVAWLKDGSPLGQDMGPHLRFYL-DGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHT 2022
Query: 341 LSVHVPPQLVTQPQD----QMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQ 396
++V VPP + Q D ++ PGE V C +G+PP + W K+G + L L
Sbjct: 2023 VNVLVPP-TIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLH 2081
Query: 397 PTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVI--L 454
+G L I+ VQ DAG + C A S AG L+++ +PPV+ +
Sbjct: 2082 GSGH-------TLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ------VPPVLEPV 2128
Query: 455 QGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEM 514
+ + +V GS V LPC G P P V W KDG+ L L+ +L + V
Sbjct: 2129 EFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLE----QGPSLQLEAVGAG 2184
Query: 515 DMGFYSCVAKSSTGEATWSGWLKMREDWGVSPD-PPTEPSSPPGAPSQPVVTEITKNSIT 573
D G YSCVA S GEA L + E + PTE S PGAP + +
Sbjct: 2185 DSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPN 2244
Query: 574 LTWKPNPQ 581
+TW + Q
Sbjct: 2245 ITWHKDGQ 2252
Score = 189 bits (479), Expect = 2e-47
Identities = 157/483 (32%), Positives = 212/483 (43%), Gaps = 55/483 (11%)
Query: 63 MPRIVEQPPDLLVSR--GEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPS 120
+P E P VS+ G P L C G P P + W K+ V E H ++
Sbjct: 1840 VPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPV----ESSAVHGVVSRG 1895
Query: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVV---V 177
G L R+ + G YTCVA N A VAVL +S G V
Sbjct: 1896 GRLQLSRLQPAQA-----GTYTCVAEN---TQAEARKDFVVAVLVAPRIRSSGVAREHHV 1947
Query: 178 AVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEG---RITIRGGKLMMSHTLKSDAGMY 234
G+ L+C G P P V+W KDG+ L ++ G R + GG L++ SDAG Y
Sbjct: 1948 LEGQEVRLDCEAD-GQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAY 2006
Query: 235 VCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAP---VTFLCEVKGDPPPRLRW 291
CVA N AGE ++ V VL P+ + L P VT +C V+G PP + W
Sbjct: 2007 TCVAHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSW 2065
Query: 292 RKEDGELPTGRYEI--RSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQL 349
K+ LP + + S H+L I V D G +TCVA + G A+ + +L V VPP L
Sbjct: 2066 LKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVL 2125
Query: 350 --VTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRG 407
V D + G V CE +G P P + W K+G +L SQSL+
Sbjct: 2126 EPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLL---SQSLE--------QGP 2174
Query: 408 QLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQG--PANQTLVLG 465
L + AV GD+G Y C AVS AG L + PP I P +L G
Sbjct: 2175 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME------PPHIEDSGQPTELSLTPG 2228
Query: 466 SSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKS 525
+ + L C G PQP++ W KDGQ L + N + ++ D G Y+C+A+S
Sbjct: 2229 APMELLCDAQGTPQPNITWHKDGQAL-------TRLENNSRATRVLRVRDAGLYTCLAES 2281
Query: 526 STG 528
G
Sbjct: 2282 PAG 2284
Score = 181 bits (459), Expect = 4e-45
Identities = 148/493 (30%), Positives = 215/493 (43%), Gaps = 52/493 (10%)
Query: 69 QPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRI 128
QP +L ++ G P L C A+G P+PNI W+K+G + + + RA R+L
Sbjct: 2219 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVL----------- 2267
Query: 129 VHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVV----------VA 178
R R D G+YTC+A + GA S V V Q+P N+V +A
Sbjct: 2268 ----RVR-DAGLYTCLAESPAGAIEK---SFRVRV------QAPPNIVGPRGPRFVVGLA 2313
Query: 179 VGEPAVLECVPPRGHPEPSVSWRKDGARLKEE-EGRITIRGGKLMMSHTLKSDAGMYVCV 237
G+ VLEC P P ++W +DG L+E+ + RG L + +D+G Y C
Sbjct: 2314 PGQ-LVLEC-SVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCT 2371
Query: 238 ASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGE 297
A N AG S A V + P+ P V + C+ G P P + WRK+
Sbjct: 2372 ARNAAGST-SVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVP 2430
Query: 298 LP--TGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQD 355
L + R+EI + SL I V A+D G Y C+A NS G L V PP + P +
Sbjct: 2431 LDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSN 2490
Query: 356 QMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQ 415
CE G+P P + W K+G Q L F Q G + + P L +TA
Sbjct: 2491 LTLTAHTPALLPCEASGSPKPLVVWWKDG-QKLDFRLQQ----GAYRLLPSNALLLTAPG 2545
Query: 416 RGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVT 475
D+ + C + G A L ++ +PP I + T+ + + V L C T
Sbjct: 2546 PQDSAQFECVVSNEVGE--AHRLYQVTVH----VPPTIADDQTDFTVTMMAPVVLTCHST 2599
Query: 476 GNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGW 535
G P P+V W K G L ++ +G L I + G Y+C A++S G A +
Sbjct: 2600 GIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVF 2659
Query: 536 LKMREDWGVSPDP 548
L ++ V P P
Sbjct: 2660 LTVQASPVVKPLP 2672
Score = 176 bits (446), Expect = 1e-43
Identities = 151/496 (30%), Positives = 218/496 (43%), Gaps = 44/496 (8%)
Query: 63 MPRIVEQPPD---LLVSR-GEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLL 118
+P ++Q D LVSR GE T+ C G P ++ W K+G + P + R LL
Sbjct: 2027 VPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL------PLSQRTLL 2080
Query: 119 PSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRD-DFRQSPGNVVV 177
G+ RI + A D G++TCVA + G A RN +L+V V + + +VVV
Sbjct: 2081 -HGSGHTLRISKVQLA--DAGIFTCVAASPAGVA-DRNFTLQVQVPPVLEPVEFQNDVVV 2136
Query: 178 AVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCV 237
G L C RG P P VSW KDG L + +G L + D+G Y CV
Sbjct: 2137 VRGSLVELPC-EARGVPLPLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSCV 2192
Query: 238 ASNMAGERESAAAEVMVLERPSF--LRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKED 295
A + AGE ++ V+E P +P + AP+ LC+ +G P P + W K+
Sbjct: 2193 AVSEAGEARRHF-QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG 2251
Query: 296 GELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQD 355
L R+ L + D G YTC+AE+ G E S + V PP +V
Sbjct: 2252 QALTRLENNSRATRVLRV-----RDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGP 2306
Query: 356 QMA---APGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNIT 412
+ APG+ V +C + P P I W ++G + GRF L +
Sbjct: 2307 RFVVGLAPGQLV-LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF-------LQLQ 2358
Query: 413 AVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPC 472
A+ D+G Y C A + AGS +EI P I GP + + + LPC
Sbjct: 2359 ALSTADSGDYSCTARNAAGSTSVAFRVEIHTV------PTIRSGPPAVNVSVNQTALLPC 2412
Query: 473 RVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATW 532
+ G P P V W+KD L +F+ + G+L I V D G Y C+A +S G
Sbjct: 2413 QADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQ 2472
Query: 533 SGWLKMREDWGVSPDP 548
L++ E ++P P
Sbjct: 2473 GRDLRVLEPPAIAPSP 2488
Score = 174 bits (441), Expect = 5e-43
Identities = 140/497 (28%), Positives = 213/497 (42%), Gaps = 48/497 (9%)
Query: 73 LLVSRGEPATLPCRAEGRPRPNIEWYKNGARV----ATVREDPRAHRLLLPSGALFFPRI 128
L V G P L C G P P I W K+G + A ++ RLL
Sbjct: 890 LTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYL--------- 940
Query: 129 VHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDF--RQSPGNVVVAVGEPAVLE 186
G+ EG YTC N +G + S++ LEV V R+ P V V A LE
Sbjct: 941 --GQAQLAQEGTYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLE 997
Query: 187 CVPPRGHPEPSVSWRKDGARLKEEEG-RITIRGGKLMMSHTLKSDAGMYVCVASNMAGER 245
C G P P+V+W +DG + E G ++ +G L + + G Y CVA N+AG
Sbjct: 998 C-NATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 1056
Query: 246 ESAAAEVMVLERPSFLRR--PVNQVVLA-DAPVTFLCEVKGDPPPRLRWRKEDGELPTGR 302
E E+ VL P + P+ + A +P+T LCE G PPP +RW + + + G
Sbjct: 1057 ERKF-ELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGE 1115
Query: 303 --YEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQM--A 358
Y + L + +D G Y+C+A N G A + S+ V VPP + + +++
Sbjct: 1116 DTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKV 1175
Query: 359 APGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGD 418
G++ C G+P P + W K+G + + + P G L +
Sbjct: 1176 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVL-------LQVLQANLSS 1228
Query: 419 AGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQ-----TLVLGSSVWLPCR 473
AG+Y C A + G L + L P IL G + T+ + + + L C
Sbjct: 1229 AGHYSCIAANAVGEKTKHFQLSVL------LAPTILGGAEDSADEEVTVTVNNPISLICE 1282
Query: 474 VTGNPQPSVRWKKDGQWLQGD-DLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATW 532
P P++ W KDG + ++Q +G L I N Q+ D G Y+CV + GEA
Sbjct: 1283 ALAFPSPNITWMKDGAPFEASRNIQLLPGTHG-LQILNAQKEDAGQYTCVVTNELGEAVK 1341
Query: 533 SGWLKMREDWGVSPDPP 549
+ +++ +S D P
Sbjct: 1342 NYHVEVLIPPSISKDDP 1358
Score = 172 bits (435), Expect = 3e-42
Identities = 153/529 (28%), Positives = 229/529 (43%), Gaps = 70/529 (13%)
Query: 49 DPSLNGSRVGPEDAMPRIVEQPPDLLVS--RGEPATLPCRAEGRPRPNIEWYKNGARVAT 106
+P LN V P P I E VS G+ TL C A G P P I W K+ V
Sbjct: 6 EPLLNTGSVVP----PSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGV 61
Query: 107 VRE-----------DPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASR 155
HRLL +L FPRI G D G+Y+C A N G A
Sbjct: 62 PLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEG-----DSGLYSCRAENQAGTA--- 113
Query: 156 NASLEVAVLRDDFRQSPG---NVVVAVGEPAVLECVPPRGHPEPSVSWRKD-------GA 205
+ VL G V+ G L+C G P P V W KD G
Sbjct: 114 QRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGP 172
Query: 206 RLK-EEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFL--R 262
L+ +E+G++ ++ SH D G Y CVA + AG+ ++ ++ V P+
Sbjct: 173 HLQVQEDGQVL----RITGSHV--GDEGRYQCVAFSPAGQ-QARDFQLRVHAPPTIWGSN 225
Query: 263 RPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEI--RSDHSLWIGHVSAED 320
V+ D V LCE +G P P + W K+ LPT + R L +G + D
Sbjct: 226 ETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSD 285
Query: 321 EGTYTCVAENSVGRAEASGSLSVHVPPQLV---TQPQDQMAAPGESVAFQCETKGNPPPA 377
G YTC A N+VG AE + L V+VPP + +P A G VA +C +G+P P
Sbjct: 286 AGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPT 345
Query: 378 IFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKA 437
+ W EG V L+ G L + + +G Y C A S AG + +
Sbjct: 346 LSWHHEGLPVAESNESRLETDG-------SVLRLESPGEASSGLYSCVASSPAGEAVLQY 398
Query: 438 LLEIKGASLDGLPPVIL--QGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDD 495
+E++ +PP +L +G T ++G + LPC+ +G+P P+++W ++G+ ++
Sbjct: 399 SVEVQ------VPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR--PAEE 450
Query: 496 LQFKTMAN--GTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDW 542
L +A+ TL+I +V+ G ++C A + G A + + +W
Sbjct: 451 LAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEW 499
Score = 169 bits (428), Expect = 2e-41
Identities = 187/656 (28%), Positives = 268/656 (40%), Gaps = 81/656 (12%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
P I+ + ++ V E L C++ P P + W+K+G + +PR L AL
Sbjct: 789 PSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPL-----EPRPGVHLSADKAL 843
Query: 124 FFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPA 183
+ R D G YTC A N G + ++ +L V V + + V G P
Sbjct: 844 ----LQVDRADVWDAGHYTCEALNQAGHS-EKHYNLNVWVAPVFPLRESHTLTVREGHPT 898
Query: 184 VLECVPPRGHPEPSVSWRKDGARLKEEEG---RITIRGGKLMMSHTLKSDAGMYVCVASN 240
L C RG P P +SWRKDG L E ++ G L + + G Y C SN
Sbjct: 899 RLSC-ECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN 957
Query: 241 MAGER-ESAAAEVMVLERPSFLRRPVNQV-VLADAPVTFLCEVKGDPPPRLRWRKEDGEL 298
+ G + EV V + + R P QV V+ D T C G PPP + W + DG+
Sbjct: 958 VVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWER-DGQ- 1015
Query: 299 PTGR---YEIRSD-HSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLV--TQ 352
P G ++++ SL + A G Y+CVAEN GRAE LSV VPP+L+
Sbjct: 1016 PVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLD 1075
Query: 353 PQDQMAAPGES-VAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNI 411
P + A S + CE G PPPAI W + V P + + ++ L +
Sbjct: 1076 PLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVS--PGEDT-----YLLAGGWMLKM 1128
Query: 412 TAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVL--GSSVW 469
T Q D+G Y C A + AG +E+ +PP I + + + G +
Sbjct: 1129 TQTQEQDSGLYSCLASNEAGEARRNFSVEVL------VPPSIENEDLEEVIKVLDGQTAH 1182
Query: 470 LPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGE 529
L C VTG+PQP + W KDG+ L D + L + G YSC+A ++ GE
Sbjct: 1183 LMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGE 1242
Query: 530 ATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSY 589
T L V P + A + VT N I+L
Sbjct: 1243 KTKHFQL------SVLLAPTILGGAEDSADEEVTVT--VNNPISL--------------- 1279
Query: 590 VIEAFS-PAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRA----VGAWGLSEPSPVS 644
+ EA + P+ TW + DG E L P T L ++ A G + + +
Sbjct: 1280 ICEALAFPSPNITW--MKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 1337
Query: 645 EPVRTQDSS----PSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQV-SWTVDGP 695
E V+ PS +DP LAEV V+ + V TL+ SW V P
Sbjct: 1338 EAVKNYHVEVLIPPSISKDDP------LAEVGVKEVKTKVNSTLTLECESWAVPPP 1387
Score = 168 bits (426), Expect = 3e-41
Identities = 149/499 (29%), Positives = 211/499 (42%), Gaps = 75/499 (15%)
Query: 72 DLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHG 131
++ V+ P +L C A P PNI W K+GA R LLP HG
Sbjct: 1268 EVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQ-----LLPG--------THG 1314
Query: 132 RRA----RPDEGVYTCVARNYLGAAASRNASLEV----AVLRDDFRQSPG--NVVVAVGE 181
+ + D G YTCV N LG A +N +EV ++ +DD G V V
Sbjct: 1315 LQILNAQKEDAGQYTCVVTNELGEAV-KNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNS 1373
Query: 182 PAVLEC----VPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLM-MSHTLKSDAGMYVC 236
LEC VPP P++ W KDG + + G+L+ + T SD+G Y+C
Sbjct: 1374 TLTLECESWAVPP-----PTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLC 1428
Query: 237 VASNMAGERE-------------------SAAAEVMVLERPSFLRRPVNQVVLADAPVTF 277
VA+N+AGE + SAA E++ E + + ++ + P
Sbjct: 1429 VATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYL 1488
Query: 278 LCEVKGDPPPRLRWRKEDGELPTGRYE--IRSDHSLWIGHVSAEDEGTYTCVAENSVGRA 335
C+ PPP L W +ED L G ++ L I V AE+ G Y+C A N VG
Sbjct: 1489 YCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGED 1548
Query: 336 EASGSLSVHVPPQLVTQPQDQMAA----PGESVAFQCETKGNPPPAIFWQKEGSQVLLFP 391
L V PP ++ ++ + +V+ QC GNP P I W + G
Sbjct: 1549 WLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLP----- 1603
Query: 392 SQSLQPTGRFSVSPRGQ-LNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLP 450
P+ R V GQ L ++ + DA Y+C A + AGS L ++ +P
Sbjct: 1604 ---FSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ------VP 1654
Query: 451 PVILQGPANQ-TLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIA 509
P I Q T +L SSV LPC V +P P V W KD Q L + F TL +
Sbjct: 1655 PRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLG 1714
Query: 510 NVQEMDMGFYSCVAKSSTG 528
+ D G Y+C A ++ G
Sbjct: 1715 RARLSDSGMYTCEALNAAG 1733
Score = 164 bits (416), Expect = 4e-40
Identities = 130/454 (28%), Positives = 194/454 (42%), Gaps = 24/454 (5%)
Query: 137 DEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEP 196
DEG+YTC A N G + R +L+V V + P N V LEC+ G P P
Sbjct: 577 DEGIYTCAATNLAGES-KREVALKVLV-PPNIEPGPVNKAVLENASVTLECLAS-GVPPP 633
Query: 197 SVSWRKDGARLKEEEG-RITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVL 255
VSW K + G +++ G L + SDAG Y CVASN+AG E + +
Sbjct: 634 DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV 693
Query: 256 ERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL-PTGRYEIR---SDHSL 311
L + VL + PV C G P P L W K+ + P G ++ L
Sbjct: 694 PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVL 753
Query: 312 WIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETK 371
+ A D G Y+CVA ++VG L VH+PP ++ + + ESVA +C++
Sbjct: 754 TLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSH 813
Query: 372 GNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAG 431
PPP + W K+G + P L + + L + DAG+Y C+A++ AG
Sbjct: 814 AMPPPVLSWWKDGRPLEPRPGVHLS-------ADKALLQVDRADVWDAGHYTCEALNQAG 866
Query: 432 SILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWL 491
L + A P L+ T+ G L C G P P + W+KDGQ L
Sbjct: 867 HSEKHYNLNVWVA-----PVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPL 921
Query: 492 QGD--DLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVS--PD 547
G+ LQ + LY+ Q G Y+C + G ++ L++ ++ +
Sbjct: 922 PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPRE 981
Query: 548 PPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQ 581
PPT+ S + K T+TW+ + Q
Sbjct: 982 PPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ 1015
Score = 164 bits (415), Expect = 5e-40
Identities = 129/468 (27%), Positives = 201/468 (42%), Gaps = 37/468 (7%)
Query: 75 VSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRA 134
+ PA L C P P++ WY+ ++ E +L G + +V A
Sbjct: 1480 IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVS-----VLQGGRVLQIPLVRAENA 1534
Query: 135 RPDEGVYTCVARNYLGAAASRNASLEVA--VLRDDFRQSPGNVVVAVGEPAVLECVPPRG 192
G Y+C A N +G L + V+ D + V V L+C P G
Sbjct: 1535 ----GRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC-PALG 1589
Query: 193 HPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLK-SDAGMYVCVASNMAGERESAAAE 251
+P P++SW ++G + G+++ T + +DA Y+CVA N AG E
Sbjct: 1590 NPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFT- 1648
Query: 252 VMVLERPSFLRRPVNQVV-LADAPVTFLCEVKGDPPPRLRWRKEDGELPTGR--YEIRSD 308
+ V P + QV + ++ V+ C+V P P + W K+ L G + +
Sbjct: 1649 LRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGT 1708
Query: 309 HSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPP---QLVTQPQDQ-MAAPGESV 364
H+L +G D G YTC A N+ GR + LSV VPP Q PQD + G+
Sbjct: 1709 HTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKA 1768
Query: 365 AFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVC 424
CET P P + W K+G ++L G+ +L I Q D G Y C
Sbjct: 1769 VLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ-------RLEIQEAQVSDKGLYSC 1821
Query: 425 QAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTL--VLGSSVWLPCRVTGNPQPSV 482
+ +VAG + L ++ +PP + P +T+ V GS + L C V+G P P+V
Sbjct: 1822 KVSNVAGEAVRTFTLTVQ------VPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPTV 1874
Query: 483 RWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEA 530
W KD ++ + G L ++ +Q G Y+CVA+++ EA
Sbjct: 1875 TWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEA 1922
Score = 155 bits (391), Expect = 3e-37
Identities = 148/478 (30%), Positives = 198/478 (41%), Gaps = 56/478 (11%)
Query: 78 GEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPD 137
G P L C A G P P + W+ G VA E RL L R P
Sbjct: 329 GRPVALECVARGHPSPTLSWHHEGLPVAESNES----RLETDGSVL--------RLESPG 376
Query: 138 E---GVYTCVARNYLGAAASRNASLEVAVLRDDF-RQSPGNVVVAVGEPAVLECVPPRGH 193
E G+Y+CVA + G A + S+EV V + G V VG+P L C G
Sbjct: 377 EASSGLYSCVASSPAGEAVLQY-SVEVQVPPQLLVAEGLGQVTTIVGQPLELPC-QASGS 434
Query: 194 PEPSVSWRKDGARLKEEEG-RITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEV 252
P P++ W ++G +E G ++ +G L + H +G++ C A+N AG +A AEV
Sbjct: 435 PVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG---TAGAEV 491
Query: 253 MVLER----PSFLRRPVNQV-----------VLADAPVTFLCEVKGDPPPRLRWRKED-- 295
V P L P+ Q D PV PP W
Sbjct: 492 EVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSL 551
Query: 296 -GELPTGRYEIRS-DHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQP 353
GE PTG S L I V DEG YTC A N G ++ +L V VPP + P
Sbjct: 552 WGE-PTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGP 610
Query: 354 QDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITA 413
++ SV +C G PPP + W K V + ++ GR L I
Sbjct: 611 VNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV-------LRIEQ 663
Query: 414 VQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCR 473
Q DAG Y C A +VAGS + L + LPP L GP +++ + V L C
Sbjct: 664 AQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPP-SLPGP----VLVNTPVRLTCN 718
Query: 474 VTGNPQPSVRWKKDGQWLQGDDLQFKTMANG--TLYIANVQEMDMGFYSCVAKSSTGE 529
TG P P++ W KDG + + G L +A+ + D G YSCVA S+ GE
Sbjct: 719 ATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGE 776
Score = 153 bits (386), Expect = 1e-36
Identities = 143/485 (29%), Positives = 203/485 (41%), Gaps = 50/485 (10%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVA-----TVREDPRAHRLLL 118
P I P + V TL C A G P P++ W+K V+ TV D R R+
Sbjct: 604 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRI-- 661
Query: 119 PSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQS-PGNVVV 177
+ D G Y CVA N G+ R R S PG V+
Sbjct: 662 ------------EQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVL- 708
Query: 178 AVGEPAVLECVPPRGHPEPSVSWRKDGARLKE--EEGRITIRGGK-LMMSHTLKSDAGMY 234
V P L C G P P++ W KDG + G GG+ L ++ SD+G Y
Sbjct: 709 -VNTPVRLTC-NATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 766
Query: 235 VCVASNMAGE-RESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRK 293
CVA + GE R+ +V + PS L +N V+A+ V C+ PPP L W K
Sbjct: 767 SCVAVSAVGEDRQDVVLQVHM--PPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK 824
Query: 294 EDGEL-PTGRYEIRSDHS-LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVT 351
+ L P + +D + L + D G YTC A N G +E +L+V V P
Sbjct: 825 DGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPL 884
Query: 352 QPQDQMAA-PGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQ-L 409
+ + G CE +G P P I W+K+G + P + G VS G+ L
Sbjct: 885 RESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPL---PGEG---AGLQHVSAVGRLL 938
Query: 410 NITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVIL---QGPANQTLVLGS 466
+ Q G Y C+ +V G+ LE+ +PP I + P ++V
Sbjct: 939 YLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVH------VPPQIAGPREPPTQVSVVQDG 992
Query: 467 SVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANG-TLYIANVQEMDMGFYSCVAKS 525
L C TG P P+V W++DGQ + G +L + G +L++ Q G YSCVA++
Sbjct: 993 VATLECNATGKPPPTVTWERDGQPV-GAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN 1051
Query: 526 STGEA 530
G A
Sbjct: 1052 LAGRA 1056
Score = 148 bits (374), Expect = 3e-35
Identities = 143/490 (29%), Positives = 206/490 (42%), Gaps = 42/490 (8%)
Query: 57 VGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRL 116
V P+ A PR E P + V + ATL C A G+P P + W ++G V
Sbjct: 972 VPPQIAGPR--EPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGA-----ELGLQ 1024
Query: 117 LLPSGALFFPRIVHGRRARPDE-GVYTCVARNYLGAAASRNASLEVAV---LRDDFRQSP 172
L G + +H RA+ G Y+CVA N G A R L V V L D
Sbjct: 1025 LQNQG-----QSLHVERAQAAHTGRYSCVAENLAGRA-ERKFELSVLVPPELIGDLDPLT 1078
Query: 173 GNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGG-KLMMSHTLKSDA 231
N+ A+ P L C G P P++ W + + E + GG L M+ T + D+
Sbjct: 1079 -NITAALHSPLTLLC-EAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDS 1136
Query: 232 GMYVCVASNMAGE-RESAAAEVMVLERPSFLRRPVNQV--VLADAPVTFLCEVKGDPPPR 288
G+Y C+ASN AGE R + + EV+V PS + +V VL +C V G P P+
Sbjct: 1137 GLYSCLASNEAGEARRNFSVEVLV--PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPK 1194
Query: 289 LRWRKEDGELPTG-RYEIRSDHSLW-IGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVP 346
L W K+ L G + I D L + + G Y+C+A N+VG LSV +
Sbjct: 1195 LTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLA 1254
Query: 347 PQLVTQPQDQM-----AAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRF 401
P ++ +D ++ CE P P I W K+G+ + L P
Sbjct: 1255 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTH- 1313
Query: 402 SVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIK-GASLDGLPPVILQGPANQ 460
L I Q+ DAG Y C + G + +E+ S+ P+ G
Sbjct: 1314 ------GLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEV 1367
Query: 461 TLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLY-IANVQEMDMGFY 519
+ S++ L C P P++RW KDGQ + + + + G L I Q D G Y
Sbjct: 1368 KTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSS-RLQVLGEGRLLQIQPTQVSDSGRY 1426
Query: 520 SCVAKSSTGE 529
CVA + GE
Sbjct: 1427 LCVATNVAGE 1436
Score = 129 bits (324), Expect = 2e-29
Identities = 139/502 (27%), Positives = 201/502 (40%), Gaps = 51/502 (10%)
Query: 72 DLLVSRGEPATLPCRAEGRPRPNIEWYKN------GARVATVREDPRAHRLLLPSGALFF 125
++L G L C G P P +EW K+ G V+ED + R+
Sbjct: 135 EVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRIT-------- 186
Query: 126 PRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVL 185
G DEG Y CVA + G A R+ L V + + V + + V
Sbjct: 187 -----GSHVG-DEGRYQCVAFSPAGQQA-RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQ 239
Query: 186 ECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGK-LMMSHTLKSDAGMYVCVASNMAGE 244
RG P P+++W KDGA L + RGG+ L + SDAG+Y C ASN G
Sbjct: 240 LLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA 299
Query: 245 RESAAAEVMVLERPSFLR---RPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELP-- 299
E A + V P+ RP +A PV C +G P P L W E LP
Sbjct: 300 AEKAT-RLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEG--LPVA 356
Query: 300 -TGRYEIRSDHS-LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQL-VTQPQDQ 356
+ + +D S L + G Y+CVA + G A S+ V VPPQL V + Q
Sbjct: 357 ESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQ 416
Query: 357 MAA-PGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQ 415
+ G+ + C+ G+P P I W + G P++ L G S L+I V+
Sbjct: 417 VTTIVGQPLELPCQASGSPVPTIQWLQNGR-----PAEEL--AGVQVASQGTTLHIDHVE 469
Query: 416 RGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVT 475
+G + CQA + AG+ A+ + + G G+ V + G + SS C
Sbjct: 470 LDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPI-GQYHWGXEHHSSFPAACDPP 528
Query: 476 ------GNPQPSV--RWKKDGQ-WLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSS 526
+P+P + W G W + + L I V D G Y+C A +
Sbjct: 529 VHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNL 588
Query: 527 TGEATWSGWLKMREDWGVSPDP 548
GE+ LK+ + P P
Sbjct: 589 AGESKREVALKVLVPPNIEPGP 610
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 213 bits (543), Expect = 8e-55
Identities = 242/923 (26%), Positives = 370/923 (40%), Gaps = 122/923 (13%)
Query: 60 EDAMPRIVEQPPDLLVS-RGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLL 118
+D P +P V G L C AEG +W N + + +R ++
Sbjct: 22 DDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLE---YRYMI 78
Query: 119 PSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVA 178
S R G Y C+ RN +GA R ++VA + F + + V+
Sbjct: 79 TS------------LDRTHAGFYRCIVRNRMGALLQRQTEVQVAYM-GSFEEGEKHQSVS 125
Query: 179 VGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVA 238
GE AV+ P+P V+W +DG ++ L++ T+ DAG Y A
Sbjct: 126 HGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQA 185
Query: 239 SN-MAGERESAAAEVMVLER---------PSFLRRPVN-QVVLADAPVTFLCEVKGDPPP 287
N G+ +++ + +E P+ + P N VV + VT C P
Sbjct: 186 VNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLI 245
Query: 288 RLR--WRKEDGELPTGRYEIRSDHS--LWIGHVSAEDEGTYTCVA---ENSVGRAEASGS 340
+L W+K DG L +G SDH+ L I + + D G Y C A +SV
Sbjct: 246 KLHIIWKK-DGVLLSGGI---SDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAY 301
Query: 341 LSVHVPPQLVTQPQDQMAAPGESVA-FQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTG 399
LSV PPQ V +P+ + A E V C+ KG PPP+I W K+ + V ++
Sbjct: 302 LSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVV------EVEKLT 355
Query: 400 RFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPAN 459
RF G L I+ + D G + C A + AG + L + + P I +GP +
Sbjct: 356 RFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTS-----IAPNITRGPLD 410
Query: 460 QTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQ---FKTMANGTLYIANVQEMDM 516
T++ G SV L C +G P+P++ W+K + L +Q F + +G+L I+ D
Sbjct: 411 STVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDA 470
Query: 517 GFYSCVAKSSTG----EATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPV--VTEITKN 570
G Y+C+A +S G A W + R PP + S G + V VT +
Sbjct: 471 GTYTCLATNSRGVDEASADLVVWARTR-----ITKPPQDQSVIKGTQASMVCGVTHDPRV 525
Query: 571 SITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVR 630
+I W+ + T + I R +G + T SG I + R
Sbjct: 526 TIRYIWEKDGATLGTESHPRI-----------RLDRNGSLHISQTWSG----DIGTYTCR 570
Query: 631 AVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSW 690
+ A G ++ VR +P PV L+ V R + ++W
Sbjct: 571 VISAGG-NDSRSAHLRVRQLPHAPEHPVAT-------LSTVE----------RRAINLTW 612
Query: 691 T--VDGPVQLVQGFRVSWRVAGPEGGSWT-MLDLQSPSQQSTVLRGLPPGTQIQIKVQAQ 747
T DG L++ P WT +L P S ++GL P Q ++ A
Sbjct: 613 TKPFDGNSPLIRYILEMSENNAP----WTVLLASVDPKATSVTVKGLVPARSYQFRLCAV 668
Query: 748 GQEGLGAESLSVTR-SIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEY 806
G G S R S+PEE P+ PPQ V + G N SI + W+PP S QNG++ Y
Sbjct: 669 NDVGKGQFSKDTERVSLPEEPPTAPPQNVIAS--GRTNQSIMIQWQPPPESHQNGILKGY 726
Query: 807 QI-WCL-GNESRFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPV---- 860
I +CL G + + +L L+ Y VAA SAG+GV S+ V
Sbjct: 727 IIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWT 786
Query: 861 LVQLPSPPDLEPGLEVGAGLAVRLARVLREPAFLAGSGAACGALLLGLCAALYWRRKQRK 920
L +P+ P E +R P F+ +G G L+ W +Q +
Sbjct: 787 LQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFI--NGINQGYKLIA------WEPEQEE 838
Query: 921 ELSHYTASFAYTPAVSFPHSEGL 943
E++ TA + ++ GL
Sbjct: 839 EVTMVTARPNFQDSIHVGFVSGL 861
Score = 212 bits (539), Expect = 2e-54
Identities = 277/1114 (24%), Positives = 432/1114 (38%), Gaps = 162/1114 (14%)
Query: 75 VSRGEPATLPC-RAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRR 133
VS GE A + R P+P + W+++G ++ P + R+ + +V
Sbjct: 124 VSHGEAAVIRAPRIASFPQPQVTWFRDGRKI------PPSSRIAIT----LENTLVILST 173
Query: 134 ARPDEGVYTCVARNYLGAAASRNASLEVAV---------LRDDFRQSPGNVVVAVGEPAV 184
PD G Y A N + + + V + P N V G V
Sbjct: 174 VAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEV 233
Query: 185 -LECVP-PRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMA 242
LECV R + + W+KDG L G I+ +L + + SDAG Y C A +
Sbjct: 234 TLECVANARPLIKLHIIWKKDGVLLS---GGISDHNRRLTIPNPTGSDAGYYECEAVLRS 290
Query: 243 GERESAA--AEVMVLERPSFLRRPVNQVVLA-DAPVTFLCEVKGDPPPRLRWRKEDGELP 299
S A + VLE P F++ P + + V C+ KG PPP + W K+ +
Sbjct: 291 SSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVE 350
Query: 300 TG---RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV-HVPPQLVTQPQD 355
R+ R+D L I + +D G + C A N+ G + S L+V + P + P D
Sbjct: 351 VEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLD 410
Query: 356 QMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQ 415
G SV CET G P PAI WQK G ++L S L RF+ G L I+
Sbjct: 411 STVIDGMSVVLACETSGAPRPAITWQK-GERILASGSVQLP---RFTPLESGSLLISPTH 466
Query: 416 RGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVT 475
DAG Y C A + G A A L + + I + P +Q+++ G+ + C VT
Sbjct: 467 ISDAGTYTCLATNSRGVDEASADLVVWARTR------ITKPPQDQSVIKGTQASMVCGVT 520
Query: 476 GNPQPSVR--WKKDGQWLQGDDL-QFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATW 532
+P+ ++R W+KDG L + + + NG+L+I+ D+G Y+C S+ G +
Sbjct: 521 HDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSR 580
Query: 533 SGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVT--EITKNSITLTWKPNPQTGAAVTSYV 590
S L++R+ P AP PV T + + +I LTW + + Y+
Sbjct: 581 SAHLRVRQ--------------LPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYI 626
Query: 591 IEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQ 650
+E A T + + + TV GL P Y F + AV G + S +E V
Sbjct: 627 LEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLP 686
Query: 651 DSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAG 710
+ P+ P ++ + + ++ Q P P + Q +++G+ + + +AG
Sbjct: 687 EEPPTAPPQNVIASGRTNQSIMIQWQPP----PESHQNG--------ILKGYIIRYCLAG 734
Query: 711 PEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSG 770
G + ++ + +L L T +I+V A GLG S VT + P+
Sbjct: 735 LPVG-YQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTV 793
Query: 771 PPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQI--WCLGNESRFHLNRSAAGWAR 828
PP V +++I +W P P NG+ Y++ W E + + +
Sbjct: 794 PPGNVHAE--ATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQD 851
Query: 829 SAMLRGLVPGLL----YRTLVAAATSAGVGVPSAPVLVQL-PSPPDLEPGLEVGAGLAVR 883
S + G V GL Y T V T+ G G S P LV+ P L L
Sbjct: 852 SIHV-GFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTS 910
Query: 884 LARVLREPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHY-------------TASFA 930
L +EP G +L G + + ++HY TA
Sbjct: 911 LKVSWQEPGEKNG-------ILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTT 963
Query: 931 YTPAVSFPHSEGLSGASSR------PPMGLGPAPYSWLADSWPHPSRSPSAQEPRGSCCP 984
YT V+ S+G S+ PP GP +++ P RS + Q G
Sbjct: 964 YTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGP---RSVTLQFRPG---- 1016
Query: 985 SNPDPDDRYYNEAGISLYLAQTARGTAAPGEGPVYSTIDPAGEELQTFHGGFPQHPSGDL 1044
Y + IS +L + G GEG + I E P DL
Sbjct: 1017 --------YDGKTSISRWLVEAQVGVV--GEGEEWLLIHQLSNEPDARSMEVP-----DL 1061
Query: 1045 GPWSQYAPPEWSQGDSGAKGGKVKLLGKPVQMPSLNWPEALPPPPPSCELSCLEGPEE-- 1102
P++ Y+ +M +N PP PS ++ L+ P +
Sbjct: 1062 NPFTCYS----------------------FRMRQVNIVGTSPPSQPSRKIQTLQAPPDMA 1099
Query: 1103 ----ELEGSSEPEEWC--PPMPERSHLTEPSSSG 1130
L +SE W P+PE + P S G
Sbjct: 1100 PANVSLRTASETSLWLRWMPLPEMEYNGNPESVG 1133
Score = 159 bits (402), Expect = 2e-38
Identities = 216/849 (25%), Positives = 328/849 (38%), Gaps = 98/849 (11%)
Query: 58 GPEDAM-PRIVEQPPDLLVSRG-EPATLPCRAEGRP--RPNIEWYKNGARVATVREDPRA 113
GP D + P I+ P + V G TL C A RP + +I W K+G ++ D
Sbjct: 208 GPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHN- 266
Query: 114 HRLLLPSGALFFPRIVHGRRARPDEGVYTC--VARNYLGAAASRNASLEVAVLRDDFRQS 171
RL +P+ D G Y C V R+ + R A L V + F +
Sbjct: 267 RRLTIPNPT------------GSDAGYYECEAVLRSSSVPSVVRGAYLSV-LEPPQFVKE 313
Query: 172 PGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEE-GRITIRG-GKLMMSHTLKS 229
P + A E V +G P PS++W KD A ++ E+ R R G L +S +
Sbjct: 314 PERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPD 373
Query: 230 DAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRL 289
D GM+ C A N AGE +++ + P+ R P++ V+ V CE G P P +
Sbjct: 374 DTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAI 433
Query: 290 RWRKEDGELPTG-----RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVH 344
W+K + L +G R+ SL I D GTYTC+A NS G EAS L V
Sbjct: 434 TWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVW 493
Query: 345 VPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAI--FWQKEGSQVLLFPSQSLQPTGRFS 402
++ PQDQ G + C +P I W+K+G+ + + R
Sbjct: 494 ARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATL------GTESHPRIR 547
Query: 403 VSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTL 462
+ G L+I+ GD G Y C+ +S G+ A L ++ PV +
Sbjct: 548 LDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRA 607
Query: 463 VLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCV 522
+ + W GN P +R+ + + A T+ +A+V D S
Sbjct: 608 I--NLTWTK-PFDGN-SPLIRYILE---------MSENNAPWTVLLASV---DPKATSVT 651
Query: 523 AKSSTGEATWSGWLKMREDWGVSP-DPPTE----PSSPPGAPSQPVVTE-ITKNSITLTW 576
K ++ L D G TE P PP AP Q V+ T SI + W
Sbjct: 652 VKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQW 711
Query: 577 KPNPQT--GAAVTSYVIE--AFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAV 632
+P P++ + Y+I G ++ + D + + L T Y V A
Sbjct: 712 QPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITD-ADVNNLLLEDLIIWTNYEIEVAAY 770
Query: 633 GAWGLS-EPSPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWT 691
+ GL S V+E W QG+ V T++ +W
Sbjct: 771 NSAGLGVYSSKVTE----------------WT-LQGVPTVPPGNVHAEATNSTTIRFTWN 813
Query: 692 VDGPVQLVQGFRVSWRVAG--PEGGSWTMLDLQSPSQQSTV----LRGLPPGTQIQIKVQ 745
P Q + G +++ PE + P+ Q ++ + GL T+ V
Sbjct: 814 APSP-QFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVL 872
Query: 746 AQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITE 805
G G S E+ P GP ++ + D +S+ VSW+ P ++NG++T
Sbjct: 873 CFTTPGDGPRSTPQLVRTHEDVP-GPVGHLSFSEILD--TSLKVSWQE--PGEKNGILTG 927
Query: 806 YQI-WCLGNESRFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVL--- 861
Y+I W N + + + GL Y VAA TS G G SA +
Sbjct: 928 YRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSG 987
Query: 862 --VQLPSPP 868
+LP PP
Sbjct: 988 VPPELPGPP 996
Score = 79.7 bits (195), Expect = 2e-14
Identities = 82/332 (24%), Positives = 142/332 (42%), Gaps = 31/332 (9%)
Query: 552 PSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGN--TWRTV---A 606
P PG P+ ++ I S+TL ++P +++ +++EA G W + +
Sbjct: 989 PPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLS 1048
Query: 607 DGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWRGQQ 666
+ + V L P T Y F +R V G S PS S ++T + P
Sbjct: 1049 NEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPD----------M 1098
Query: 667 GLAEVAVRLQEPIVLGPRTLQV-SWTVDGPVQLVQGFRVSWRVAGPEGGSWTMLDLQSPS 725
A V++R L R + + +G + V G+++ + + G + + + +Q
Sbjct: 1099 APANVSLRTASETSLWLRWMPLPEMEYNGNPESV-GYKIKYSRSDGHGKTLSHV-VQDRV 1156
Query: 726 QQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNS 785
++ + L T+ +++VQA G G S +V E PS P V+ +S
Sbjct: 1157 ERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSAL--ATTSS 1214
Query: 786 SITVSWEPPLPSQQNGVITEYQIWCLGNES----RFHLNRSAAGWARSAMLRGLVPGLLY 841
S+ V W + +NG++ Y++ +S RF L + +RSA L GL +LY
Sbjct: 1215 SMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNS--SRSAQLTGLGKYVLY 1272
Query: 842 RTLVAAATSAGVGVPSAPVLVQ-----LPSPP 868
V A T G G PS P +++ +P PP
Sbjct: 1273 EVQVLAFTRIGDGSPSHPPILERTLDDVPGPP 1304
Score = 75.5 bits (184), Expect = 3e-13
Identities = 90/351 (25%), Positives = 136/351 (38%), Gaps = 24/351 (6%)
Query: 539 REDWGVSPDP---PTEPSSPPGAPSQPVVTE--ITKNSITLTWKPNPQTGAAVTSYVIEA 593
R+ WG + + TE P PS+P+V + + S+ L+W+P + V Y I+
Sbjct: 1380 RKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQT 1439
Query: 594 FSPAAGNTWRTVADGVQ--LETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQD 651
+G W + V + V L+P T Y F V+A G SE S SE + T
Sbjct: 1440 RELPSGR-WALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQ 1498
Query: 652 SSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFR-VSWRVAG 710
++P V +R Q P + + + + L +G R + R
Sbjct: 1499 AAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGIN 1558
Query: 711 PEGGSW-------TMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSI 763
G +W +M +L PS L L + +I++ G G S +
Sbjct: 1559 NPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFV 1618
Query: 764 PEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQI--WCLGNESRFHLNR 821
E P+ P+ V V G + + V+WEPP QNG I Y+I W + +
Sbjct: 1619 GEAVPTAAPRNVVVH--GATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVK 1676
Query: 822 SAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQ----LPSPP 868
+ S L+ L Y VAA +AG G S P Q PS P
Sbjct: 1677 TLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAP 1727
Score = 55.5 bits (132), Expect = 4e-07
Identities = 133/609 (21%), Positives = 218/609 (35%), Gaps = 103/609 (16%)
Query: 552 PSSPP-----------GAPSQPVVTEITKNSITLTWKPNP--QTGAAVTSYVIEAFSPAA 598
PSSPP AP VV T + +TW+P P + Y I +
Sbjct: 1609 PSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQR 1668
Query: 599 GNTWRTVADGVQLETHT-VSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVR--TQDSSPS 655
GN V E + L T Y+ V A A G P S P + TQ ++PS
Sbjct: 1669 GNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAG---DGPRSTPTQGQTQQAAPS 1725
Query: 656 RPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDG-PVQLVQGFRVSWRVAGPEGG 714
P +V+ E L ++ VSW P +++G+R+ + P G
Sbjct: 1726 APS-------------SVKFSE---LTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDG 1769
Query: 715 --SWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPP 772
+D++ S ++ L G + +++A+ G E + + P E GPP
Sbjct: 1770 VSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFT-YGPEIEANVTTGPGEGAPGPP 1828
Query: 773 QGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRF------HLNRSAAGW 826
GV + + +S+I + W P + G IT Y I ++ + + + +
Sbjct: 1829 -GVPIIVRY--SSAIAIHWSSGDPGK--GPITRYVIEARPSDEGLWDILIKDIPKEVSSY 1883
Query: 827 ARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPDLEPGLEVGAGLAVRLAR 886
S + L PG+ Y V A G G PS+P + + A
Sbjct: 1884 TFSMDI--LKPGVSYDFRVIAVNDYGFGTPSSP-----------------SQSVPAQKAN 1924
Query: 887 VLREPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTASFAYTPAVSFPHSEGLS-G 945
E + A G + + L + R Q K+ + T S + + HSE +S
Sbjct: 1925 PFYEEWWFLVVIALVGLIFILLLVFVLIIRGQSKKYAKKTDSGNSAKSGALGHSEMMSLD 1984
Query: 946 ASSRPPMGLGPAPYSWLADSWPHPSRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLY--- 1002
SS P + L S + +S+ + + PR P P +Y++ ++ Y
Sbjct: 1985 ESSFPALELNNRRLS-VKNSFCRKNGLYTRSPPR-------PSPGSLHYSDEDVTKYNDL 2036
Query: 1003 -LAQTARGTAAPGE------GPVYSTIDPAGEELQTFHGGFPQHPSGDLGPW-------S 1048
A+++ T P E +D ++ +F + P+ W S
Sbjct: 2037 IPAESSSLTEKPSEISDSQGSDSEYEVDSNHQKAHSFVNHYISDPT-YYNSWRRQQKGIS 2095
Query: 1049 QYAPPEWSQGDSGAKGGKVKLLGKPVQMPSLNWPEAL-------PPPPPSCELSCLEGPE 1101
+ +++ DSG Q SL P+A PP PPS + + P
Sbjct: 2096 RAQAYSYTESDSGEPDHTTVTNSTSTQQGSLFRPKASRTPTPQNPPNPPSQQSTLYRPPS 2155
Query: 1102 EELEGSSEP 1110
GS P
Sbjct: 2156 SLAPGSRAP 2164
Score = 51.2 bits (121), Expect = 7e-06
Identities = 84/352 (23%), Positives = 138/352 (39%), Gaps = 38/352 (10%)
Query: 537 KMREDWGVSPDPPTEPS-------SPPG-APSQPVVTEITKNSITLTWKPNPQ-----TG 583
+MR+ V PP++PS +PP AP+ + ++ S+ L W P P+
Sbjct: 1070 RMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNP 1129
Query: 584 AAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPV 643
+V + + S G T V +T+ L+ T Y V+A A G S P
Sbjct: 1130 ESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG-SGPWSQ 1188
Query: 644 SEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFR 703
+ RT++S PS G ++ +A +V + LV G++
Sbjct: 1189 TVVGRTRESVPS-------SGPTNVSALATTSSSMLVRWSEVPEADRN-----GLVLGYK 1236
Query: 704 VSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSI 763
V ++ + L ++ S +S L GL +++V A + G G+ S
Sbjct: 1237 VMYKEKDSDTQPRFWL-VEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILER 1295
Query: 764 PEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLN--R 821
+ GPP G + +S+ + W+P P+ NG+I YQI N + +
Sbjct: 1296 TLDDVPGPPMG--ILFPEVRTTSVRLIWQP--PAAPNGIILAYQITHRLNTTTANTATVE 1351
Query: 822 SAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLV-----QLPSPP 868
A AR GL P +Y + A T G G + ++V P PP
Sbjct: 1352 VLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPP 1403
Score = 39.7 bits (91), Expect = 0.020
Identities = 58/260 (22%), Positives = 99/260 (38%), Gaps = 29/260 (11%)
Query: 542 WGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQT--GAAVTSYVI---EAFSP 596
W + T S P P+ T +S+ + W P+ V Y + E S
Sbjct: 1186 WSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSD 1245
Query: 597 AAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSR 656
W + +G + ++GL +Y V A G PS RT D P
Sbjct: 1246 TQPRFW--LVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGP 1303
Query: 657 PVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDG-PVQLVQGFRVSWRVAGPEGGS 715
P+ G+ VR ++++ W P ++ ++++ R+ +
Sbjct: 1304 PM--------GILFPEVRTT--------SVRLIWQPPAAPNGIILAYQITHRLNTTTANT 1347
Query: 716 WTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLG--AESLSVTRSIPEEAPSGPPQ 773
T+ ++ +PS + GL P + ++ AQ ++G G AE+L VT + P PP
Sbjct: 1348 ATV-EVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTE-KRDRPQ-PPS 1404
Query: 774 GVAVALGGDGNSSITVSWEP 793
V S+ +SWEP
Sbjct: 1405 RPMVQQEDVRARSVLLSWEP 1424
Score = 32.0 bits (71), Expect = 4.2
Identities = 12/36 (33%), Positives = 22/36 (61%)
Query: 1154 ATLTPSPPDPPQPPTDMPHLHQMPRRVPLGPSSPLS 1189
A+ TP+P +PP PP+ L++ P + G +P++
Sbjct: 2131 ASRTPTPQNPPNPPSQQSTLYRPPSSLAPGSRAPIA 2166
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 208 bits (529), Expect = 3e-53
Identities = 216/819 (26%), Positives = 331/819 (40%), Gaps = 79/819 (9%)
Query: 65 RIVEQPPDLLVSRGEPATLPCRAEG-RPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
R + +P D + RG L C AE R P I+W K+G +A ++ + L +G+L
Sbjct: 41 RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQ---LSNGSL 97
Query: 124 FFPRIVHGRRARPDEGVYTCVAR-NYLGAAASRNASLEVA-VLRDDFRQSPGNVVVAVGE 181
I+H R +PDEG+Y C A G+ SR A + VA LR F +V +G+
Sbjct: 98 LIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLR--FLSQTESVTAFMGD 155
Query: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEEEGR---ITIRGGKLMMSHTLKSDAGMYVCVA 238
+L+C G P P++ W+K+ L G + + G L +S D G+Y C A
Sbjct: 156 TVLLKC-EVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSA 214
Query: 239 SNMAGERESAAAEVMVLERPS------FLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWR 292
N A R AEV +L P FL+RP N V + C V G PPP W
Sbjct: 215 RNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWL 274
Query: 293 KEDG--ELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLV 350
+ + +L + +Y + +L I +V+ +D G YTCV AS L+V VPP +
Sbjct: 275 RGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFL 334
Query: 351 TQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLN 410
P + A + F+C G P P + W K G V+ P+ F + L
Sbjct: 335 NHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVI--------PSDYFQIVGGSNLR 386
Query: 411 ITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWL 470
I V + D G+Y C A + AG+ A L + ++ V+ P + VL SS ++
Sbjct: 387 ILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPS-SSVLPSAPRDVVPVLVSSRFV 445
Query: 471 ------PCRVTGNPQP-SVRWKKDGQWLQGDDLQFKTMANGTLY--IANVQEMDMGFYSC 521
P GN Q +V + ++G + T G+L + N++ M +
Sbjct: 446 RLSWRPPAEAKGNIQTFTVFFSREG---DNRERALNTTQPGSLQLTVGNLKPEAMYTFRV 502
Query: 522 VAKSSTGEATWSGWLKMREDWGVSPDPPTEPS-SPPGAPSQPVVTEITKNSITLTWKPNP 580
VA + G S +K+ T+P PG + SI +TW+P
Sbjct: 503 VAYNEWGPGESSQPIKV----------ATQPELQVPGPVENLQAVSTSPTSILITWEPPA 552
Query: 581 QTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEP 640
V Y + + G DG+ ++ + GL+ T Y A +G
Sbjct: 553 YANGPVQGYRLFCTEVSTGKEQNIEVDGL---SYKLEGLKKFTEYSLRFLAYNRYG-PGV 608
Query: 641 SPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQ 700
S V T PS P ++ V L+ V+ R+++VSW + P
Sbjct: 609 STDDITVVTLSDVPSAPPQN------------VSLE---VVNSRSIKVSW-LPPPSGTQN 652
Query: 701 GFRVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVT 760
GF +++ + ++ P+ + GL G+Q +V A G G S T
Sbjct: 653 GFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYT 712
Query: 761 RSIPE---EAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRF 817
PE + P Q ++ + N I +SW PPL N V+ Y I G S +
Sbjct: 713 AETPENDLDESQVPDQPSSLHVRPQTN-CIIMSWTPPL--NPNIVVRGYIIG-YGVGSPY 768
Query: 818 HLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVP 856
R + L Y + A +AG GVP
Sbjct: 769 AETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVP 807
Score = 107 bits (266), Expect = 1e-22
Identities = 194/853 (22%), Positives = 321/853 (37%), Gaps = 115/853 (13%)
Query: 67 VEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFP 126
+++P +++ G+ A L C G P P+ W + G V +R + LL L
Sbjct: 243 LQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-GEEVIQLRSKKYS---LLGGSNLLIS 298
Query: 127 RIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLE 186
+ D G+YTCV Y S +A L V V F P N+ E
Sbjct: 299 NVTDD-----DSGMYTCVV-TYKNENISASAELTVLV-PPWFLNHPSNLYAYESMDIEFE 351
Query: 187 CVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERE 246
C G P P+V+W K+G + + + G L + +KSD G Y CVA N AG +
Sbjct: 352 CTVS-GKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQ 410
Query: 247 SAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWR-----KEDGELPTG 301
++A +++ +P+ + VL AP + + RL WR K + + T
Sbjct: 411 TSAQ--LIVPKPAI----PSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTV 464
Query: 302 RYEIRSDH-------------SLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQ 348
+ D+ L +G++ E T+ VA N G E+S P +
Sbjct: 465 FFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQ------PIK 518
Query: 349 LVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQ 408
+ TQP+ Q+ P E++ + P +I E P Q + VS +
Sbjct: 519 VATQPELQVPGPVENL----QAVSTSPTSILITWEPPAYANGPVQGYRLFCT-EVSTGKE 573
Query: 409 LNITAVQRGDAGYYVCQAVSVAGSILAKALLEIK---GASLDGLPPVILQG-----PANQ 460
NI D Y + + + L + G S D + V L P N
Sbjct: 574 QNIEV----DGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNV 629
Query: 461 TLVLGSSVWLPCRVTGNPQPS-----------VRWKKDGQWLQGDDLQFKTMANGTLYIA 509
+L + +S + +V+ P PS +R +K + + + L+ N Y+
Sbjct: 630 SLEVVNSRSI--KVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLE----PNNLWYLF 683
Query: 510 NVQEMDMGF-YSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEIT 568
E + + A + G S W +P+ + S P PS V T
Sbjct: 684 TGLEKGSQYSFQVSAMTVNGTGPPSNWYTAE-----TPENDLDESQVPDQPSSLHVRPQT 738
Query: 569 KNSITLTWKPNPQTGAAVTSYVIE--AFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYL 626
N I ++W P V Y+I SP A TV + +++ L+ ++ Y+
Sbjct: 739 -NCIIMSWTPPLNPNIVVRGYIIGYGVGSPYA----ETVRVDSKQRYYSIERLESSSHYV 793
Query: 627 FLVRAVGAWGLSEP-------SPVSEPVRTQDSSP---SRPVEDPWRGQQGLAEVAVRLQ 676
++A G P +++P D P P P L V V
Sbjct: 794 ISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGV--- 850
Query: 677 EPIVLGPRTLQVSWTVDG-----PVQLVQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTVL 731
+ + L ++VSW + V+ + V WR + + D S S +T
Sbjct: 851 QAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTAT-- 908
Query: 732 RGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITVSW 791
GL P T + V S++ + E AP+ P+ + V ++ VSW
Sbjct: 909 -GLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSW 967
Query: 792 EPPLPSQQNGVITEYQIWCLGNES---RFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAA 848
+PPL + NG IT Y ++ +++ + + +G + + L +Y + A
Sbjct: 968 QPPL--EANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQAR 1025
Query: 849 TSAGVGVPSAPVL 861
S GVG S P+L
Sbjct: 1026 NSKGVGPLSDPIL 1038
Score = 37.4 bits (85), Expect = 0.10
Identities = 27/95 (28%), Positives = 36/95 (37%), Gaps = 22/95 (23%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
P + P +L C G+P P + W KNG +++PS
Sbjct: 331 PWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNG-------------DVVIPSD-- 375
Query: 124 FFPRIVHGRRAR------PDEGVYTCVARNYLGAA 152
+ +IV G R DEG Y CVA N G A
Sbjct: 376 -YFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNA 409
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 208 bits (529), Expect = 3e-53
Identities = 220/852 (25%), Positives = 345/852 (40%), Gaps = 105/852 (12%)
Query: 60 EDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDP-------R 112
ED P+I+ + +VS EP +L C +G P P I W T+ +DP R
Sbjct: 403 EDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITW--------TLDDDPILKGGSHR 454
Query: 113 AHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSP 172
+++ G + + + R D GVY C A N G + + V +
Sbjct: 455 ISQMITSEGNVVSYLNISSSQVR-DGGVYRCTANNSAGVVLYQ---ARINVRGPASIRPM 510
Query: 173 GNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRG-GKLMMSHTLKS-D 230
N+ G + C G+P S+ W K+ L ++ G L +S K D
Sbjct: 511 KNITAIAGRDTYIHC-RVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVD 569
Query: 231 AGMYVCVASNMAGERESAAAEVMVLERP-----SFLRRPVNQVVLADAPVTFLCEVKGDP 285
G Y C S + V V P F R + Q V V V GD
Sbjct: 570 EGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVV-----VSGDL 624
Query: 286 PPRLRWRKEDGELPTGRYEIRSDH-----SLWIGHVSAEDEGTYTCVAENSVGRAEASGS 340
P + W+K+ +P G + D+ SL I ++S G YTC+A N E
Sbjct: 625 PITITWQKDGRPIP-GSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQ 683
Query: 341 LSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQ-KEGSQVLLFPSQSLQPTG 399
L V VPP+ V QP+DQ G++V C +G P P I W+ +G+ V F Q + G
Sbjct: 684 LIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQF--QPIALNG 741
Query: 400 RFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKAL-LEIKGASLDGLPPVILQGPA 458
R V G L I V D+GYY+C+ + G+ ++K++ L +K +P +I P
Sbjct: 742 RIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVK------IPAMITSYPN 795
Query: 459 NQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMAN-------GTLYIANV 511
G + C G VRW+K+ + + + ++ TL I
Sbjct: 796 TTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPT 855
Query: 512 QEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNS 571
D GF+SC A +S G ED G+ EP PP + + ++ +
Sbjct: 856 VREDSGFFSCHAINSYG-----------EDRGIIQLTVQEPPDPP----EIEIKDVKART 900
Query: 572 ITLTWKPNPQTGAAVTSYVIEA--FSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLV 629
ITL W + +T Y IE S + + RT QL + T+ + P++ Y +
Sbjct: 901 ITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRM 960
Query: 630 RAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVS 689
A G SEPS + +++P P ++ V L EPI ++++V+
Sbjct: 961 YAKNRIGKSEPSN-ELTITADEAAPDGPPQE------------VHL-EPI--SSQSIRVT 1004
Query: 690 WTVDG---PVQLVQGFRVSWRVAGPEGG---SWTMLDLQSPSQQSTVLRGLPPGTQIQIK 743
W +++G+++ +R G + +D S+ T L L TQ +
Sbjct: 1005 WKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYT-LDNLNKFTQYGLV 1063
Query: 744 VQAQGQEGLGAESLSVTRSIPEEAPSGPPQGV-AVALGGDGNSSITVSWEPPLPSQQNGV 802
VQA + G G S + + E+ PS PP+ V A+A + SI++SW NG+
Sbjct: 1064 VQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPE---SISISWSTLSKEALNGI 1120
Query: 803 ITEYQI--WCLGNESRFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPV 860
+ +++ W + ++ S L GL Y V A T AG GV S +
Sbjct: 1121 LQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQI 1180
Query: 861 LVQ----LPSPP 868
+ +P PP
Sbjct: 1181 FTRTKEDVPGPP 1192
Score = 168 bits (425), Expect = 4e-41
Identities = 203/834 (24%), Positives = 331/834 (39%), Gaps = 92/834 (11%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLL--PSG 121
P + ++ G + CR G P +I+WYKN + P HR + +G
Sbjct: 504 PASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLL------PFNHRQVAFENNG 557
Query: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGE 181
L + + DEG YTC + S + S+ V V F Q ++G+
Sbjct: 558 TLKLSDV----QKEVDEGEYTCNV--LVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQ 611
Query: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRG----GKLMMSHTLKSDAGMYVCV 237
+ CV G +++W+KDG + G +TI L +S+ G Y C+
Sbjct: 612 RVFIPCVVVSGDLPITITWQKDGRPIPGSLG-VTIDNIDFTSSLRISNLSLMHNGNYTCI 670
Query: 238 ASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGE 297
A N A E + +++V P F+ +P +Q + V C +G P P + W+ G
Sbjct: 671 ARNEAAAVEHQS-QLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGA 729
Query: 298 -LP-------TGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGS--LSVHVPP 347
+P GR ++ S+ SL I HV ED G Y C N VG A+ S S L+V +P
Sbjct: 730 GVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVG-ADVSKSMYLTVKIPA 788
Query: 348 QLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRG 407
+ + P +A G+ C G P + W+KE + ++ L T
Sbjct: 789 MITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVIS 848
Query: 408 QLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSS 467
L I R D+G++ C A++ G + ++++ P + ++ +T+ L
Sbjct: 849 TLQILPTVREDSGFFSCHAINSYGE--DRGIIQLTVQEPPDPPEIEIKDVKARTITL--- 903
Query: 468 VWLPCRVTGNPQPSVRWKK--DGQW-LQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAK 524
RW DG + G D++ K ++ +++ S
Sbjct: 904 ---------------RWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATII 948
Query: 525 SSTGEATWSGWLKMREDWGVSPDPPTE------PSSPPGAPSQPVVTEITKNSITLTWKP 578
+T+S + + G S +P E ++P G P + + I+ SI +TWK
Sbjct: 949 DIHPSSTYSIRMYAKNRIGKS-EPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKA 1007
Query: 579 NPQ--TGAAVTSYVIEAFSPAAGNTWR----TVADGVQLETHTVSGLQPNTIYLFLVRAV 632
+ + Y I + G ++ +V E +T+ L T Y +V+A
Sbjct: 1008 PKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQAC 1067
Query: 633 GAWGLSEPSPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTV 692
G PS T + PS P E+ + I P ++ +SW+
Sbjct: 1068 NRAGTG-PSSQEIITTTLEDVPSYPPENV---------------QAIATSPESISISWST 1111
Query: 693 DGPVQL---VQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQ 749
L +QGFRV + +G + ++ + +Q S L GL T I+V A +
Sbjct: 1112 LSKEALNGILQGFRVIYWANLMDGELGEIKNITT-TQPSLELDGLEKYTNYSIQVLAFTR 1170
Query: 750 EGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIW 809
G G S + E+ P GPP GV A S + VSW PPL + NG+I +Y ++
Sbjct: 1171 AGDGVRSEQIFTRTKEDVP-GPPAGVKAAAASA--SMVFVSWLPPL--KLNGIIRKYTVF 1225
Query: 810 CLGNESRFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQ 863
C A+ + S + L Y V A TSAG G S + V+
Sbjct: 1226 CSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVE 1279
Score = 121 bits (304), Expect = 4e-27
Identities = 145/586 (24%), Positives = 220/586 (37%), Gaps = 76/586 (12%)
Query: 59 PEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLL 118
P ++ P I++ G+ LPC+A G P P+ W K+ +
Sbjct: 220 PANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLEL------------ 267
Query: 119 PSGALFFPRIVHG---RRARP-DEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGN 174
SG F + V G RP D G Y C N G A L+ SP
Sbjct: 268 -SGR--FQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATI--SPRK 322
Query: 175 VVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEG-RIT-IRGGKLMMSHTLKSDAG 232
V +VG L C G + +SW ++G L + RIT I L+M H +KSD G
Sbjct: 323 VKSSVGSQVSLSC-SVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGG 381
Query: 233 MYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWR 292
Y C + V+ P + +VV PV+ +C VKG P P + W
Sbjct: 382 AYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWT 441
Query: 293 KEDGELPTG-----RYEIRSDHS----LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV 343
+D + G I S+ + L I D G Y C A NS G ++V
Sbjct: 442 LDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINV 501
Query: 344 HVPPQLVTQPQDQMAA-PGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFS 402
P + +P + A G C G P +I W K + L P Q +
Sbjct: 502 RGPASI--RPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSN---LLPFNHRQ----VA 552
Query: 403 VSPRGQLNITAVQRG-DAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQT 461
G L ++ VQ+ D G Y C ++ L + + P +Q
Sbjct: 553 FENNGTLKLSDVQKEVDEGEYTCNV------LVQPQLSTSQSVHVTVKVPPFIQPFEFPR 606
Query: 462 LVLGSSVWLPCRVTGNPQP-SVRWKKDGQWLQG------DDLQFKTMANGTLYIANVQEM 514
+G V++PC V P ++ W+KDG+ + G D++ F +L I+N+ M
Sbjct: 607 FSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDF----TSSLRISNLSLM 662
Query: 515 DMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSI-- 572
G Y+C+A++ L +R V P +P G + V+ +
Sbjct: 663 HNGNYTCIARNEAAAVEHQSQLIVR----VPPKFVVQPRDQDGIYGKAVILNCSAEGYPV 718
Query: 573 -TLTWKPNPQTGAAVTSYVIEAFSPAAGN-TWRTVADGVQLETHTV 616
T+ WK + G + F P A N + +++G L H V
Sbjct: 719 PTIVWKFSKGAG-------VPQFQPIALNGRIQVLSNGSLLIKHVV 757
Score = 116 bits (291), Expect = 1e-25
Identities = 123/486 (25%), Positives = 196/486 (40%), Gaps = 42/486 (8%)
Query: 83 LPCRAEGRPRPNIEWYKNGARVATVRE--DPRAHRLLLPSGAL-FFPRIVHGRRARPDEG 139
+PC A G P + WY +AT E D R + P+G L FP +
Sbjct: 44 VPCPAAGIPPVTLRWY-----LATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDN 98
Query: 140 VYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPE--PS 197
Y C A N G S++ ++ AVLR+ + + G AV +C+ P
Sbjct: 99 TYYCTAENPSGKIRSQDVHIK-AVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITV 157
Query: 198 VSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGM-YVCVASNM-AGE-RESAAAEVMV 254
VSW KD L + G L + D Y C+ + GE R+S +A + V
Sbjct: 158 VSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFV 217
Query: 255 LE----RPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELP-TGRYEIRSDH 309
+ PS L ++ +A V C+ G P P RW K++ L +GR++ ++
Sbjct: 218 SDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQ-KTVT 276
Query: 310 SLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCE 369
L I ++ D G+Y C N G A+ G L V P + P+ ++ G V+ C
Sbjct: 277 GLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCS 336
Query: 370 TKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVC--QAV 427
G + W + G +L P ++++ TG L + + + D G Y C +
Sbjct: 337 VTGTEDQELSWYRNGE--ILNPGKNVRITG----INHENLIMDHMVKSDGGAYQCFVRKD 390
Query: 428 SVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWK-K 486
++ + +LE DG P +I + + + V L C V G P P++ W
Sbjct: 391 KLSAQDYVQVVLE------DGTPKII-SAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLD 443
Query: 487 DGQWLQGDDLQFKTMANGT------LYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMRE 540
D L+G + M L I++ Q D G Y C A +S G + + +R
Sbjct: 444 DDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG 503
Query: 541 DWGVSP 546
+ P
Sbjct: 504 PASIRP 509
Score = 72.0 bits (175), Expect = 4e-12
Identities = 58/228 (25%), Positives = 100/228 (43%), Gaps = 24/228 (10%)
Query: 426 AVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWK 485
AV+ AG + ++ ++ L P IL T + LPC+ G+P P+V+W
Sbjct: 1263 AVTSAGRGNSSEIITVE--PLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM 1320
Query: 486 KDGQW---LQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDW 542
KD L D + +NG+ I V+ D G+YSC+A ++ G S + +
Sbjct: 1321 KDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG----SDEIILNLQV 1376
Query: 543 GVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTW 602
V PD P + V++ T +SITL+W P G+++ Y+++ +S W
Sbjct: 1377 QVPPDQP-----------RLTVSKTTSSSITLSWLPGDNGGSSIRGYILQ-YSEDNSEQW 1424
Query: 603 RTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQ 650
+ ++ + L+ T Y F + A G P +SE + +
Sbjct: 1425 GSFPISPSERSYRLENLKCGTWYKFTLTAQNGVG---PGRISEIIEAK 1469
Score = 56.2 bits (134), Expect = 2e-07
Identities = 30/74 (40%), Positives = 40/74 (54%), Gaps = 5/74 (6%)
Query: 279 CEVKGDPPPRLRWRKEDGELPT-----GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVG 333
C+ GDP P ++W K+ P+ GR I S+ S I V AED G Y+C+A N+ G
Sbjct: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366
Query: 334 RAEASGSLSVHVPP 347
E +L V VPP
Sbjct: 1367 SDEIILNLQVQVPP 1380
Score = 43.9 bits (102), Expect = 0.001
Identities = 70/340 (20%), Positives = 124/340 (36%), Gaps = 42/340 (12%)
Query: 313 IGHVSAEDEGTYTCVAENSVGRAEASGSLSVH----VPPQLVTQPQDQMAAPGESVAFQC 368
I ++S + + VA S GR +S ++V P +++T + + C
Sbjct: 1248 IPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPC 1307
Query: 369 ETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVS 428
+ G+P PA+ W K+ + PS + GR S+ G I V+ D+GYY C A +
Sbjct: 1308 KAVGDPSPAVKWMKDSNGT---PSL-VTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANN 1363
Query: 429 VAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDG 488
GS + +L ++ P + + + ++ L WLP G
Sbjct: 1364 NWGS--DEIILNLQVQVPPDQPRLTVSKTTSSSITLS---WLP------------GDNGG 1406
Query: 489 QWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLK--MREDWGVSP 546
++G LQ+ + + + + K T W K + GV P
Sbjct: 1407 SSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGT-------WYKFTLTAQNGVGP 1459
Query: 547 -------DPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAG 599
+ T P + Q + I + L G +TS+ +E + P
Sbjct: 1460 GRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLE-YRPFGT 1518
Query: 600 NTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSE 639
W T +++ + LQ T Y +R + G +E
Sbjct: 1519 TVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAE 1558
Score = 38.9 bits (89), Expect = 0.035
Identities = 56/236 (23%), Positives = 95/236 (40%), Gaps = 24/236 (10%)
Query: 125 FPRIVHGRRARPDEGVYTC--VARN-------YLGAAASRNASLEVAVLRDDFRQSPGNV 175
+P ++ A PD Y ++RN +A R S E+ + + ++P +
Sbjct: 1230 YPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITV-EPLAKAPARI 1288
Query: 176 VVAVGE---PAVLECVPPR---GHPEPSVSWRKDG---ARLKEEEGRITIRGGKLMMSHT 226
+ G P + + V P G P P+V W KD L +GR +I + T
Sbjct: 1289 LTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRT 1348
Query: 227 LKS-DAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDP 285
+K+ D+G Y C+A+N G E + V P R V++ + +++L G
Sbjct: 1349 VKAEDSGYYSCIANNNWGSDE-IILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGS 1407
Query: 286 PPR--LRWRKEDGELPTGRYEIR-SDHSLWIGHVSAEDEGTYTCVAENSVGRAEAS 338
R + ED G + I S+ S + ++ +T A+N VG S
Sbjct: 1408 SIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRIS 1463
Score = 35.0 bits (79), Expect = 0.50
Identities = 24/70 (34%), Positives = 35/70 (50%), Gaps = 8/70 (11%)
Query: 83 LPCRAEGRPRPNIEWYK-NGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVY 141
LPC+A G P P ++W K + + V D R R + +G+ F R V D G Y
Sbjct: 1305 LPCKAVGDPSPAVKWMKDSNGTPSLVTIDGR--RSIFSNGS-FIIRTVKAE----DSGYY 1357
Query: 142 TCVARNYLGA 151
+C+A N G+
Sbjct: 1358 SCIANNNWGS 1367
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 207 bits (526), Expect = 7e-53
Identities = 218/846 (25%), Positives = 335/846 (39%), Gaps = 101/846 (11%)
Query: 69 QPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRI 128
+P D L RG L C A P P IEW K+G + V +D R LLP G+LF +
Sbjct: 58 EPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDD---RRQLLPDGSLFISNV 114
Query: 129 VHGRRARPDEGVYTCVAR-NYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLEC 187
VH + +PDEG Y CVA LG SR A L VA L F P V G A+L C
Sbjct: 115 VHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGL-PRFTSQPEPSSVYAGNNAILNC 173
Query: 188 VPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERES 247
P V W ++ L ++ I + G L++S+ + D G+Y CV + + S
Sbjct: 174 -EVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYS 232
Query: 248 AAAEVMVLERPS------FLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTG 301
E+ VL P FL++P V + V C G P P ++W K + L T
Sbjct: 233 DEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTE 292
Query: 302 RYE---IRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMA 358
E + + SL I V+ +D GTY C+A+N EA L+V P+ + QP + A
Sbjct: 293 SSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYA 352
Query: 359 APGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGD 418
+ F+CE G P P + W K G V+ P+ F + L + + + D
Sbjct: 353 HESMDIVFECEVTGKPTPTVKWVKNGDMVI--------PSDYFKIVKEHNLQVLGLVKSD 404
Query: 419 AGYYVCQAVSVAGSILAKA---LLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVT 475
G+Y C A + G+ A A +LE A+ LP P + L S+ ++
Sbjct: 405 EGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLP----SAPRDVVASLVSTRFI----- 455
Query: 476 GNPQPSVRWKKDGQWLQGDDLQFKTM-----------------ANGTLYIANVQEMDMGF 518
+ W+ GD+L + + I N+ +
Sbjct: 456 -----KLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYI 510
Query: 519 YSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPS-SPPGAPSQPVVTEITKNSITLTWK 577
+ +A++ G S L++ T+P PG + SIT+TW+
Sbjct: 511 FRVMAQNKHGSGESSAPLRVE----------TQPEVQLPGPAPNLRAYAASPTSITVTWE 560
Query: 578 PNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGL 637
+ +Y + + G D V ++T++GL+ T Y F V A G
Sbjct: 561 TPVSGNGEIQNY--KLYYMEKGTDKEQDVD-VSSHSYTINGLKKYTEYSFRVVAYNKHGP 617
Query: 638 SEPSPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQ 697
+P VRT PS ++ + L+ V +++ + W P
Sbjct: 618 GVSTP-DVAVRTLSDVPSAAPQN------------LSLE---VRNSKSIMIHWQPPAPAT 661
Query: 698 ---LVQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLG- 753
+ G+++ +R A + S L S +Q S ++ GL GT+ +V A G G
Sbjct: 662 QNGQITGYKIRYRKASRK--SDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGP 719
Query: 754 -AESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQI-WCL 811
+ LS + + P+ + +SI VSW P P QN V+ Y I + +
Sbjct: 720 ATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP--PENQNIVVRGYAIGYGI 777
Query: 812 GNESRFHLNRSAAGW-ARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPDL 870
G+ H + R + L P Y + A + G G+P V P
Sbjct: 778 GSP---HAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTS 834
Query: 871 EPGLEV 876
E L V
Sbjct: 835 EVDLFV 840
Score = 188 bits (478), Expect = 3e-47
Identities = 193/738 (26%), Positives = 298/738 (40%), Gaps = 70/738 (9%)
Query: 144 VARNYLGAAASRNASLEV---AVLRDD----FRQSPGNVVVAVGEPAVLECVPPRGHPEP 196
+ R GAAA+R+ S A +R F P + + G +L C P P
Sbjct: 24 LGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNC-SAYSEPSP 82
Query: 197 SVSWRKDGA--RLKEEEGRITIRGGKLMMSHTL-----KSDAGMYVCVAS-NMAGERESA 248
+ W+KDG L ++ R + G L +S+ + K D G Y CVA+ G S
Sbjct: 83 KIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISR 142
Query: 249 AAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSD 308
A+++V P F +P V A CEV D P +RW + L I+
Sbjct: 143 TAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLP 202
Query: 309 HS-LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQ--------LVTQPQDQMAA 359
L I + + D G Y CV E+ G + S + + V P + QP +
Sbjct: 203 SGMLVISNATEGDGGLYRCVVESG-GPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRV 261
Query: 360 PGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDA 419
G+ V C G P P I W K + + + R + G L I+ V DA
Sbjct: 262 IGQDVVLPCVASGLPTPTIKWMKNEEAL------DTESSERLVLLAGGSLEISDVTEDDA 315
Query: 420 GYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQ 479
G Y C A + +I A+A L ++ P L+ P N + C VTG P
Sbjct: 316 GTYFCIADNGNETIEAQAELTVQAQ------PEFLKQPTNIYAHESMDIVFECEVTGKPT 369
Query: 480 PSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMR 539
P+V+W K+G + D FK + L + + + D GFY C+A++ G A L +
Sbjct: 370 PTVKWVKNGDMVIPSDY-FKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIIL 428
Query: 540 EDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKP--NPQTGAAVTSYVIEAFSPA 597
E P P AP V + ++ I LTW+ + G +T V
Sbjct: 429 EH------APATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGI 482
Query: 598 AGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRP 657
A + +++ T+ L P T+Y+F V A G E S P+R + + P
Sbjct: 483 ARERVENTSHPGEMQV-TIQNLMPATVYIFRVMAQNKHGSGESSA---PLRVE-TQPEVQ 537
Query: 658 VEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAGPEGGSWT 717
+ P + A P ++ V+W + PV G ++++ E G+
Sbjct: 538 LPGPAPNLRAYAA-----------SPTSITVTW--ETPVS-GNGEIQNYKLYYMEKGTDK 583
Query: 718 MLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAV 777
D+ S T+ GL T+ +V A + G G + V + PS PQ +++
Sbjct: 584 EQDVDVSSHSYTI-NGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSL 642
Query: 778 ALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRS-AAGWARSAMLRGLV 836
+ + SI + W+PP P+ QNG IT Y+I + + + +G S ++ GL
Sbjct: 643 EVRN--SKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD 700
Query: 837 PGLLYRTLVAAATSAGVG 854
G Y VAA T G G
Sbjct: 701 RGTEYNFRVAALTINGTG 718
Score = 159 bits (401), Expect = 2e-38
Identities = 209/838 (24%), Positives = 335/838 (39%), Gaps = 121/838 (14%)
Query: 63 MPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGA 122
+PR QP V G A L C P + W +N R + +D + LPSG
Sbjct: 151 LPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQN--RQPLLLDD---RVIKLPSGM 205
Query: 123 LFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDD-------FRQSPGNV 175
L G D G+Y CV + G + +E+ VL D F + P +
Sbjct: 206 LVISNATEG-----DGGLYRCVVES--GGPPKYSDEVELKVLPDPEVISDLVFLKQPSPL 258
Query: 176 VVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEE--EGRITIRGGKLMMSHTLKSDAGM 233
V +G+ VL CV G P P++ W K+ L E E + + GG L +S + DAG
Sbjct: 259 VRVIGQDVVLPCV-ASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGT 317
Query: 234 YVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRK 293
Y C+A N E A AE+ V +P FL++P N + F CEV G P P ++W K
Sbjct: 318 YFCIADN-GNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVK 376
Query: 294 E-DGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV--HVPP--- 347
D +P+ ++I +H+L + + DEG Y C+AEN VG A+A L + H P
Sbjct: 377 NGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTG 436
Query: 348 QLVTQPQDQMAA--PGESVAFQCETKGNPPP------AIFWQKEGSQVLLFPSQSLQPTG 399
L + P+D +A+ + T + P ++F+ KEG + ++ T
Sbjct: 437 PLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEG-----IARERVENT- 490
Query: 400 RFSVSPRGQLNITAVQRGDAGYYV--CQAVSVAGSILAKALLEIKGASLDGLPPVILQGP 457
S G++ +T A Y+ A + GS + A L + + P V L GP
Sbjct: 491 ----SHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRV-----ETQPEVQLPGP 541
Query: 458 ANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMG 517
A +S P +T + V + Q + + M GT Q++D+
Sbjct: 542 APNLRAYAAS---PTSITVTWETPVSGNGEIQ-----NYKLYYMEKGT---DKEQDVDVS 590
Query: 518 FYSCVAKSSTGEATWSGWLKMREDWGVSPDPP-----TEPSSPPGAPSQPVVTEITKNSI 572
+S +S + G P T P AP + SI
Sbjct: 591 SHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSI 650
Query: 573 TLTWK-PNPQT-GAAVTSYVIE-AFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLV 629
+ W+ P P T +T Y I + + T+ G QL + + GL T Y F V
Sbjct: 651 MIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQL-SQLIEGLDRGTEYNFRV 709
Query: 630 RAVGAWGLSEPSP-VSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQV 688
A+ G + +S D +R E P + + VR P+V ++ V
Sbjct: 710 AALTINGTGPATDWLSAETFESDLDETRVPEVP-------SSLHVR---PLV---TSIVV 756
Query: 689 SWT-VDGPVQLVQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQ 747
SWT + +V+G+ + + + P + + Q+ + L P + I ++A
Sbjct: 757 SWTPPENQNIVVRGYAIGYGIGSPHAQTIKV----DYKQRYYTIENLDPSSHYVITLKAF 812
Query: 748 GQ--EGLGAESLSVTR------------------SIPEEAPSGPPQGVAVALGGDGNSSI 787
EG+ +VTR +P+ P PP GV ++ + +I
Sbjct: 813 NNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASI--LSHDTI 870
Query: 788 TVSW-EPPLPSQQNGVITEYQIWCLGNESRFHLN---RSAAGWARSAMLRGLVPGLLY 841
++W + LP Q IT+ + + + ++ N ++A S ++ GL P LY
Sbjct: 871 RITWADNSLPKHQK--ITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLY 926
Score = 110 bits (275), Expect = 9e-24
Identities = 190/859 (22%), Positives = 325/859 (37%), Gaps = 118/859 (13%)
Query: 67 VEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFP 126
++QP L+ G+ LPC A G P P I+W KN + T + +LL G+L
Sbjct: 252 LKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSE---RLVLLAGGSLEIS 308
Query: 127 RIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAV-LRDDFRQSPGNVVVAVGEPAVL 185
+ D G Y C+A N + A E+ V + +F + P N+ V
Sbjct: 309 DVTED-----DAGTYFCIADN---GNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF 360
Query: 186 ECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGER 245
EC G P P+V W K+G + + ++ L + +KSD G Y C+A N G
Sbjct: 361 EC-EVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNA 419
Query: 246 ESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTG---- 301
+ A A++++LE P L AP + + +L WR + P G
Sbjct: 420 Q-AGAQLIILEHA-----PATTGPLPSAPRDVVASLVSTRFIKLTWRTPASD-PHGDNLT 472
Query: 302 -------------RYEIRS---DHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHV 345
R E S + + I ++ + +A+N G E+S L V
Sbjct: 473 YSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVE- 531
Query: 346 PPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGS-------QVLLFPSQSLQPT 398
TQP+ Q+ PG + + + W+ S L + +
Sbjct: 532 -----TQPEVQL--PGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKE 584
Query: 399 GRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPA 458
VS I +++ + A + G ++ + ++ +L +P P
Sbjct: 585 QDVDVSSHSY-TINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVR--TLSDVPSA---APQ 638
Query: 459 NQTLVLGSSVWL------PCRVTGNPQPS---VRWKKDGQWLQGDDLQFKTMANGTLYIA 509
N +L + +S + P T N Q + +R++K + D+ +T+ +GT
Sbjct: 639 NLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASR---KSDVT-ETLVSGTQLSQ 694
Query: 510 NVQEMDMGF---YSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTE 566
++ +D G + A + G + WL E + D P P +P+VT
Sbjct: 695 LIEGLDRGTEYNFRVAALTINGTGPATDWLSA-ETFESDLDETRVPEVPSSLHVRPLVT- 752
Query: 567 ITKNSITLTWKPNPQTGAAVTSYVIE--AFSPAAGNTWRTVADGVQLETHTVSGLQPNTI 624
SI ++W P V Y I SP A +T+ + +T+ L P++
Sbjct: 753 ----SIVVSWTPPENQNIVVRGYAIGYGIGSPHA----QTIKVDYKQRYYTIENLDPSSH 804
Query: 625 YLFLVRAVGAWGLSEP---SPVSEPVRTQD-------SSPSRPVEDPWRGQQGLAEVAVR 674
Y+ ++A G P S V+ P ++P PV DP + V V+
Sbjct: 805 YVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDP---TPMMPPVGVQ 861
Query: 675 LQEPIVLGPRTLQVSWTVDG-----PVQLVQGFRVSWRVAGPEGGSWTMLDLQSPSQQST 729
+L T++++W + + + + V W+ P T + + S
Sbjct: 862 AS---ILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPAN---TKYKNANATTLSY 915
Query: 730 VLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITV 789
++ GL P T + V S++ + E P+ PP+ V V +I V
Sbjct: 916 LVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIV 975
Query: 790 SWEPPLPSQQNGVITEYQIWC---LGNESRFHLNRSAAGWARSAMLRGLVPGLLYRTLVA 846
+W+P PS+ NG IT Y I+ + E + G + ++ L Y +
Sbjct: 976 NWQP--PSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQ 1033
Query: 847 AATSAGVGVPSAPVLVQLP 865
A S G+G S V + P
Sbjct: 1034 ARNSKGMGPMSEAVQFRTP 1052
Score = 43.9 bits (102), Expect = 0.001
Identities = 47/203 (23%), Positives = 81/203 (39%), Gaps = 30/203 (14%)
Query: 62 AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSG 121
A P ++QP ++ C G+P P ++W KNG V P + ++
Sbjct: 339 AQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVI-----PSDYFKIVKEH 393
Query: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLR------DDFRQSPGNV 175
L +V + DEG Y C+A N +G A A ++ +L +P +V
Sbjct: 394 NLQVLGLV-----KSDEGFYQCIAENDVGNA---QAGAQLIILEHAPATTGPLPSAPRDV 445
Query: 176 VVAVGEPAVLECV--PPRGHPEP-----SVSWRKDGARLKEEEGRITIRGGKLMMSHTLK 228
V ++ ++ P P SV + K+G + E T G++ ++
Sbjct: 446 VASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEG--IARERVENTSHPGEMQVTIQNL 503
Query: 229 SDAGMYV--CVASNMAGERESAA 249
A +Y+ +A N G ES+A
Sbjct: 504 MPATVYIFRVMAQNKHGSGESSA 526
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 200 bits (508), Expect = 9e-51
Identities = 208/772 (26%), Positives = 321/772 (41%), Gaps = 87/772 (11%)
Query: 135 RPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFR---------QSPGNVVVAVGEPAVL 185
+ D G YTCV N + + + D Q P V A G L
Sbjct: 186 KSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKL 245
Query: 186 ECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGER 245
EC G+P P++ WR+ + + R G L + + + DAG+Y CVA N G +
Sbjct: 246 ECFA-LGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRG-K 303
Query: 246 ESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT-GRYE 304
A ++ +P+++++ + V + V + C+ G P P +W K L T R +
Sbjct: 304 NVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQ 363
Query: 305 IRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV-HVPPQL--VTQPQDQMAAPG 361
I +L I V+ D G Y C+AEN G ++ LSV V P + + G
Sbjct: 364 IEQG-TLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVG 422
Query: 362 ESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGY 421
V +C+ K +P P W+K G +L + R ++S G L I V + DAG
Sbjct: 423 GEVVIECKPKASPKPVYTWKK-GRDIL-------KENERITISEDGNLRIINVTKSDAGS 474
Query: 422 YVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPS 481
Y C A + G+ + L +K P ++ P++ + +G S+ LPC+VT +
Sbjct: 475 YTCIATNHFGTASSTGNLVVKD------PTRVMVPPSSMDVTVGESIVLPCQVTHDHSLD 528
Query: 482 V--RWKKDGQWLQ--GDDLQFKTMAN----GTLYIANVQEMDMGFYSCVAKSSTGEATWS 533
+ W +G + D F+ + G L I N+Q G Y C+ ++S + +
Sbjct: 529 IVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAA 588
Query: 534 GWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEA 593
L +R PPG P + EIT + L+W+P P + +T YVI+A
Sbjct: 589 ADLIVR--------------GPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQA 634
Query: 594 FSPAAGNTWRTVADGVQL-----ETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVR 648
+P + W+ V+ +L T TV GL P Y F A G+ EPS SE R
Sbjct: 635 RTPFSVG-WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRR 693
Query: 649 TQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSW-TVDGPVQLVQGFR--VS 705
T+++ P + G +E L ++W TV +Q +GF V+
Sbjct: 694 TEEALPEVTPANVSGGGGSKSE---------------LVITWETVPEELQNGRGFGYVVA 738
Query: 706 WRVAGPEGGSWTMLDLQSPSQQSTVLR--GLPPGTQIQIKVQAQGQEGLGAESLSVTRSI 763
+R G W + L S V R + P + ++KV +G G S +
Sbjct: 739 FRPYGKM--IWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYS 796
Query: 764 PEEAPSGPPQGV-AVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRS 822
EE P+ PP + A +L + I V W PL + G I Y++ +E + R
Sbjct: 797 AEEEPTKPPASIFARSLSA---TDIEVFWASPL-EKNRGRIQGYEVKYWRHEDKEENARK 852
Query: 823 --AAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPDLEP 872
G S + L +LY V A SAG G SA V V PP +P
Sbjct: 853 IRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQP 904
Score = 184 bits (467), Expect = 5e-46
Identities = 203/775 (26%), Positives = 308/775 (39%), Gaps = 107/775 (13%)
Query: 64 PRIVEQPPDLLV---SRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPS 120
P +++P ++ S + L C +G P+P+I W NG V T + R +
Sbjct: 26 PIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMD----FRYSVVE 81
Query: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVG 180
G+L +++ D G Y C A N G SR A L+ A L + ++ V V G
Sbjct: 82 GSL----LINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRG 137
Query: 181 EPAVLECVPPRGHPEPSVSWRKDGARLKEEEGR-ITIRGGKLMMSHTLKSDAGMYVCVAS 239
+ VL C PP E S +W + ++ R ++ G L ++ KSD G Y CV +
Sbjct: 138 QGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVT 197
Query: 240 NMAGERESAAAEVMVLER---------PSF-LRRPVNQVVLADAPVTFLCEVKGDPPPRL 289
N + ++ R P ++ P A V C G+P P +
Sbjct: 198 NTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTI 257
Query: 290 RWRKEDGELPTGRYEIR--SDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPP 347
WR+ DG+ P R R S+ L I + ED G Y CVAENS G+ A G L+ + P
Sbjct: 258 IWRRADGK-PIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQP 316
Query: 348 QLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRG 407
+ + D A E+V ++C+ G P P W K G +L ++ +G
Sbjct: 317 NWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIE---------QG 367
Query: 408 QLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLV-LGS 466
LNIT V DAG Y C A + G I + A L + D ++ TLV +G
Sbjct: 368 TLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLL----KRVTLVKVGG 423
Query: 467 SVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSS 526
V + C+ +P+P WKK G+ + ++ + +G L I NV + D G Y+C+A +
Sbjct: 424 EVVIECKPKASPKPVYTWKK-GRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNH 482
Query: 527 TGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPV---------VTEITKNSITLTWK 577
G A+ +G L +++ PT PP + V VT I TW
Sbjct: 483 FGTASSTGNLVVKD--------PTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWS 534
Query: 578 PNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGL 637
N G+ DG E V G ++ ++R + L
Sbjct: 535 FN-------------------GHLIDFDRDGDHFE--RVGG--QDSAGDLMIRNI---QL 568
Query: 638 SEPSPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGP-- 695
V+T S + RG G E AV + E + T Q+SW GP
Sbjct: 569 KHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPE-AVTIDE---ITDTTAQLSWR-PGPDN 623
Query: 696 --------VQLVQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQ 747
+Q F V W+ T+ +L + + GL P + + + A
Sbjct: 624 HSPITMYVIQARTPFSVGWQAVS------TVPELIDGKTFTATVVGLNPWVEYEFRTVAA 677
Query: 748 GQEGLGAESLSVTRSIPEEA-PSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNG 801
G+G S + EEA P P V+ GG S + ++WE QNG
Sbjct: 678 NVIGIGEPSRPSEKRRTEEALPEVTPANVSG--GGGSKSELVITWETVPEELQNG 730
Score = 140 bits (354), Expect = 6e-33
Identities = 192/792 (24%), Positives = 302/792 (38%), Gaps = 79/792 (9%)
Query: 41 NHTLLPPGDPSLNGSRVGPEDAMPRIVEQPPDLL-VSRGEPATLPCRAEGRPRPNIEWYK 99
NH +L P P + + + P+I Q P+ + ++G L C A G P P I W +
Sbjct: 202 NHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRR 261
Query: 100 NGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASL 159
+ + R H+ +G L P + D G+Y CVA N G +R
Sbjct: 262 ADGK--PIARKARRHK---SNGILEIPNF-----QQEDAGLYECVAENSRGKNVARGQLT 311
Query: 160 EVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGG 219
A + ++ Q ++ VA+ E EC G P+P+ W K+G L + RI I G
Sbjct: 312 FYA--QPNWIQKINDIHVAMEENVFWEC-KANGRPKPTYKWLKNGEPLLTRD-RIQIEQG 367
Query: 220 KLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADA--PVTF 277
L ++ SDAGMY C+A N G S A ++ P F R + +V L V
Sbjct: 368 TLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVI 427
Query: 278 LCEVKGDPPPRLRWRKEDGELPTG-RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAE 336
C+ K P P W+K L R I D +L I +V+ D G+YTC+A N G A
Sbjct: 428 ECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTAS 487
Query: 337 ASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCE-TKGNPPPAIFWQKEGSQVLLFPSQSL 395
++G+L V P +++ P GES+ C+ T + +F ++ F
Sbjct: 488 STGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGD 547
Query: 396 QPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQ 455
G L I +Q AG YVC + + A A L ++G G P +
Sbjct: 548 HFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP--GPPEAVTI 605
Query: 456 GPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKT-MANGTLYIANVQEM 514
T S W P N P + +Q +T + G ++ V E+
Sbjct: 606 DEITDTTAQLS--WRPG--PDNHSPITMYV----------IQARTPFSVGWQAVSTVPEL 651
Query: 515 DMGFYSCVAKSSTGEATWSGW---------LKMREDWGVSPDPPTEPSSPPGAPSQPVVT 565
G + G W + + + E S TE + P P+
Sbjct: 652 IDG--KTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGG 709
Query: 566 EITKNSITLTWKPNP---QTGAAVTSYVIEAFSPAAGNTWR-TVADGVQLETHTVSGLQP 621
+K+ + +TW+ P Q G YV+ AF P W TV +
Sbjct: 710 GGSKSELVITWETVPEELQNGRGF-GYVV-AFRPYGKMIWMLTVLASADASRYVFRNESV 767
Query: 622 NTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVL 681
+ F V+ VG + P S P S+ P + P A + R L
Sbjct: 768 HPFSPFEVK-VGVFNNKGEGPFS-PTTVVYSAEEEPTKPP-------ASIFARS-----L 813
Query: 682 GPRTLQVSWTVDGPVQL----VQGFRVS-WRVAGPEGGSWTMLDLQSPSQQSTVLRGLPP 736
++V W P++ +QG+ V WR E + + + + Q ST + L
Sbjct: 814 SATDIEVFWA--SPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGN--QTSTKITNLKG 869
Query: 737 GTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLP 796
+ V+A G G S +V + + PS PP + + +S I ++W+
Sbjct: 870 SVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNI---IWNSSDSKIILNWDQVKA 926
Query: 797 SQQNGVITEYQI 808
+ Y++
Sbjct: 927 LDNESEVKGYKV 938
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 199 bits (507), Expect = 1e-50
Identities = 130/395 (32%), Positives = 191/395 (48%), Gaps = 21/395 (5%)
Query: 146 RNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGA 205
R G + + E+ R P + V G C G+P+P + W ++
Sbjct: 226 RRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTC-RAEGNPKPEIIWLRNNN 284
Query: 206 RLK-EEEGRITIRG-GKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVL---ERPSF 260
L + + R+ + G LM+ +T ++D G+Y C+A N+AGE ++ + RP+F
Sbjct: 285 ELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF 344
Query: 261 LRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGE-LPTG-RYEIRSDHSLWIGHVSA 318
+ +P N VL VT C G PPPR+ W + D LP R I L+I +V
Sbjct: 345 VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQ 404
Query: 319 EDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAI 378
D G Y C A N++ A+ + V PQ PQD++ G++V FQCE KGNPPP I
Sbjct: 405 GDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVI 464
Query: 379 FWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKAL 438
W K GSQ L R V G L I+ V D G Y CQAV++ GS A
Sbjct: 465 AWTKGGSQ--------LSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAH 516
Query: 439 LEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQF 498
L ++ + PV P++ T+ +G++V LPC G P+P++ W KDG + + +F
Sbjct: 517 LTVQ----PRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVT-ESGKF 571
Query: 499 KTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWS 533
G L I +V D G Y CVA+++ G A+ S
Sbjct: 572 HISPEGFLTINDVGPADAGRYECVARNTIGSASVS 606
Score = 193 bits (490), Expect = 1e-48
Identities = 126/384 (32%), Positives = 181/384 (47%), Gaps = 24/384 (6%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
PRI +P D V+ G CRAEG P+P I W +N + +++ D R + LL G L
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNEL-SMKTDSRLN--LLDDGTL 302
Query: 124 FFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEV--AVLRDDFRQSPGNVVVAVGE 181
D+G+Y C+A+N G ++ +L + R F P N V VGE
Sbjct: 303 MIQ-----NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGE 357
Query: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIR-GGKLMMSHTLKSDAGMYVCVASN 240
LEC GHP P +SW + + R+ I G L + + ++ D+G Y C A+N
Sbjct: 358 SVTLEC-SATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
Query: 241 MAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT 300
+ A A ++V P F P ++VV+ V F CE KG+PPP + W K +L
Sbjct: 417 NI-DSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV 475
Query: 301 G-RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV--HVPPQLVTQPQDQM 357
R+ + S +L I V+ D+G Y C A N +G + L+V V P + P D
Sbjct: 476 DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
Query: 358 AAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRG 417
G +V C ++G P PAI W K+G QV +G+F +SP G L I V
Sbjct: 536 VEVGANVQLPCSSQGEPEPAITWNKDGVQV--------TESGKFHISPEGFLTINDVGPA 587
Query: 418 DAGYYVCQAVSVAGSILAKALLEI 441
DAG Y C A + GS +L +
Sbjct: 588 DAGRYECVARNTIGSASVSMVLSV 611
Score = 135 bits (340), Expect = 3e-31
Identities = 93/287 (32%), Positives = 134/287 (46%), Gaps = 14/287 (4%)
Query: 62 AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSG 121
A P V QP + V GE TL C A G P P I W + V DPR + + PSG
Sbjct: 340 ARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPV--DPRVN--ITPSG 395
Query: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGE 181
L+ +V G D G Y C A N + + + A + V L F +P + VV G+
Sbjct: 396 GLYIQNVVQG-----DSGEYACSATNNIDSVHA-TAFIIVQAL-PQFTVTPQDRVVIEGQ 448
Query: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNM 241
+C +G+P P ++W K G++L + + + G L +S D G Y C A N+
Sbjct: 449 TVDFQC-EAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNI 507
Query: 242 AGERESAA-AEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELP- 299
G ++ A V P F P + V A V C +G+P P + W K+ ++
Sbjct: 508 IGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTE 567
Query: 300 TGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVP 346
+G++ I + L I V D G Y CVA N++G A S LSV+VP
Sbjct: 568 SGKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVP 614
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 199 bits (505), Expect = 2e-50
Identities = 205/769 (26%), Positives = 305/769 (39%), Gaps = 82/769 (10%)
Query: 137 DEGVYTCVARNYLGAAASRNASLEVAVLRDDFR---------QSPGNVVVAVGEPAVLEC 187
D G YTCV + + A + + + D Q P + A G LEC
Sbjct: 190 DVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLEC 249
Query: 188 VPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERES 247
G+P P ++WR+ + ++ G L + + + DAG Y C+A N G +
Sbjct: 250 FA-LGNPIPQINWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRG-KNV 307
Query: 248 AAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRS 307
A + +P +++ + + + + + C G P P RW K L
Sbjct: 308 ARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQIE 367
Query: 308 DHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVP-PQLVTQPQDQMAAP--GESV 364
+ +L I ++S D G + C+AEN G +S L V P P ++ G V
Sbjct: 368 NGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLV 427
Query: 365 AFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVC 424
+ C+ + +P W+K S+Q R S+ G L I V + DAG Y C
Sbjct: 428 SLDCKPRASPRALSSWKKG--------DVSVQEHERISLLNDGGLKIANVTKADAGTYTC 479
Query: 425 QAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSV-- 482
A + G L + P I P+N + +G SV LPC+V +P +
Sbjct: 480 MAENQFGKANGTTHLVVTE------PTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIF 533
Query: 483 ---------RWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWS 533
+KKDG + + ++G L I N+Q G Y C+ ++ + +
Sbjct: 534 TWYFNGALADFKKDGSHFE----KVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSA 589
Query: 534 GWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEA 593
L +R PG P V EIT + L+WK + V SY I+A
Sbjct: 590 ADLIVR--------------GSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQA 635
Query: 594 FSP--AAGNTWRTVADGVQLETHT--VSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRT 649
+P T TV + + +THT V L P Y F V A G EPS SE VRT
Sbjct: 636 RTPFSVGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRT 695
Query: 650 QDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVA 709
+++ P P + G +E+ + +P+ P LQ G+ V++R
Sbjct: 696 EEAVPEVPPSEVNGGGGSRSELVITW-DPV---PEELQNGEGF--------GYVVAFRPL 743
Query: 710 GPEGGSWTMLDLQSPSQQSTVLRG--LPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEA 767
G +W + SP V R + P + ++KV +G G S T EE
Sbjct: 744 GVT--TWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEE 801
Query: 768 PSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQI--WCLGNESRFHLNRSAAG 825
P+ P V+ +S I VSW NG + Y++ W G + AG
Sbjct: 802 PTVAPSQVSA--NSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMKVAG 859
Query: 826 WARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQL-PSPPDLEPG 873
SA LRGL L Y T V A SAG G SA V V +PP PG
Sbjct: 860 NETSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNVTTKKTPPSQPPG 908
Score = 181 bits (458), Expect = 6e-45
Identities = 196/767 (25%), Positives = 313/767 (40%), Gaps = 90/767 (11%)
Query: 64 PRIVEQPPDLLV---SRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPS 120
P +++P + + S + TL C A G P P+ W NG+ + E HR L
Sbjct: 26 PVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLNGSDIDMSME----HRYKLNG 81
Query: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVG 180
G L +V D G Y C A N LG SR A L+ A L + + V V G
Sbjct: 82 GNL----VVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREG 137
Query: 181 EPAVLECVPPRGHPEPSVSWR-KDGARLKEEEGR--ITIRGGKLMMSHTLKSDAGMYVCV 237
+ VL C PP E S +W + EE+ R ++ G L +S SD G Y CV
Sbjct: 138 QGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCV 197
Query: 238 ASNMA-GERESAAAEVMVLERPSFLRR---------PVNQVVLADAPVTFLCEVKGDPPP 287
++M R + +VL + P + V C G+P P
Sbjct: 198 VTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIP 257
Query: 288 RLRWRKEDGELPTGRYEIRSDHS-LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVP 346
++ WR+ DG + + ++R L I + ED G+Y C+AENS G+ A G L+ +
Sbjct: 258 QINWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAK 317
Query: 347 PQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPR 406
P V +D A +S+ ++C G P P+ W K G+ ++L ++
Sbjct: 318 PHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQIE---------N 368
Query: 407 GQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQ--TLVL 464
G L I+ + D+G + C A + G + + A L++ ++ P + P + + +
Sbjct: 369 GALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASA-----PDFSKNPMKKLVQVQV 423
Query: 465 GSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAK 524
GS V L C+ +P+ WKK +Q + + + +G L IANV + D G Y+C+A+
Sbjct: 424 GSLVSLDCKPRASPRALSSWKKGDVSVQEHE-RISLLNDGGLKIANVTKADAGTYTCMAE 482
Query: 525 SSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGA 584
+ G+A + L + TEP+ APS V+ + + +P
Sbjct: 483 NQFGKANGTTHLVV-----------TEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDI 531
Query: 585 AVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVS 644
T Y F+ A + + DG E V G + + ++ L
Sbjct: 532 IFTWY----FNGALADFKK---DGSHFE--KVGGSSSGDLMIRNIQ------LKHSGKYV 576
Query: 645 EPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSW---------TVDGP 695
V+T S S + RG G E V++ E + T Q+SW +
Sbjct: 577 CMVQTGVDSVSSAADLIVRGSPGPPE-NVKVDE---ITDTTAQLSWKEGKDNHSPVISYS 632
Query: 696 VQLVQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAE 755
+Q F V W+ T+ ++ + + L P + + +V A + G G
Sbjct: 633 IQARTPFSVGWQTV------TTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEP 686
Query: 756 SLSVTRSIPEEA-PSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNG 801
SL + EEA P PP V GG S + ++W+P QNG
Sbjct: 687 SLPSEKVRTEEAVPEVPPS--EVNGGGGSRSELVITWDPVPEELQNG 731
Score = 157 bits (397), Expect = 7e-38
Identities = 197/769 (25%), Positives = 309/769 (40%), Gaps = 77/769 (10%)
Query: 64 PRIVEQPPDLL-VSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGA 122
P+I Q P+ L ++G L C A G P P I W ++ + + R SG
Sbjct: 227 PKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRSDGLPFSSKIKLRKF-----SGV 281
Query: 123 LFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEP 182
L P + D G Y C+A N G +R A + + Q +V +AV +
Sbjct: 282 LEIPNF-----QQEDAGSYECIAENSRGKNVARGRLTYYA--KPHWVQLIKDVEIAVEDS 334
Query: 183 AVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMA 242
EC G P+PS W K+GA L EE R I G L +S+ +D+GM+ C+A N
Sbjct: 335 LYWEC-RASGKPKPSYRWLKNGAALVLEE-RTQIENGALTISNLSVTDSGMFQCIAENKH 392
Query: 243 GERESAAAEVMVLERPSFLRRPVNQVVLADAP--VTFLCEVKGDPPPRLRWRKEDGELPT 300
G S+A +V P F + P+ ++V V+ C+ + P W+K D +
Sbjct: 393 GLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWKKGDVSVQE 452
Query: 301 G-RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAA 359
R + +D L I +V+ D GTYTC+AEN G+A + L V P ++ P + +
Sbjct: 453 HERISLLNDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMDVS 512
Query: 360 PGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDA 419
GESV C+ + +P I + + L + + S G L I +Q +
Sbjct: 513 VGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHS 572
Query: 420 GYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQ 479
G YVC + S+ + A L ++G+ G P + T S W + N
Sbjct: 573 GKYVCMVQTGVDSVSSAADLIVRGSP--GPPENVKVDEITDTTAQLS--WKEGK--DNHS 626
Query: 480 PSVRWKKDGQWLQGDDLQFKT----MANGTLYIANVQEMDMGF---YSCVAKSSTGEATW 532
P + + + Q T + +G + A V E++ + VA + G
Sbjct: 627 PVISYSIQARTPFSVGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEP 686
Query: 533 S-GWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNP---QTGAAVTS 588
S K+R + V PP+E + G+ S+ V+T W P P Q G
Sbjct: 687 SLPSEKVRTEEAVPEVPPSEVNGGGGSRSELVIT----------WDPVPEELQNGEGF-G 735
Query: 589 YVIEAFSPAAGNTW-RTVADGVQLETHTV--SGLQPNTIYLFLVRAVGAWGLSEPSPVSE 645
YV+ AF P TW +TV + + P + Y VG + P S
Sbjct: 736 YVV-AFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEV---KVGVYNNKGEGPFS- 790
Query: 646 PVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVS 705
PV T S+ P P ++V+ L ++VSW P +L G +
Sbjct: 791 PVTTVFSAEEEPTVAP-------SQVSANS-----LSSSEIEVSWNTI-PWKLSNGHLLG 837
Query: 706 -----WRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVT 760
W G E S M + ++ S LRGL V+A G G S +V
Sbjct: 838 YEVRYWNGGGKEESSSKMK--VAGNETSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVN 895
Query: 761 RSIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIW 809
+ + PS PP V + ++ + ++WE + +T Y+++
Sbjct: 896 VTTKKTPPSQPPGNV---VWNATDTKVLLNWEQVKAMENESEVTGYKVF 941
Score = 100 bits (248), Expect = 1e-20
Identities = 84/298 (28%), Positives = 129/298 (43%), Gaps = 27/298 (9%)
Query: 62 AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSG 121
A P V+ D+ ++ + CRA G+P+P+ W KNGA A V E+ R + +G
Sbjct: 316 AKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGA--ALVLEE----RTQIENG 369
Query: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGN--VVVAV 179
AL + + D G++ C+A N G S +A L+V DF ++P V V V
Sbjct: 370 ALTISNL-----SVTDSGMFQCIAENKHGLVYS-SAELKVVASAPDFSKNPMKKLVQVQV 423
Query: 180 GEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVAS 239
G L+C PR P SW+K ++E E + G L +++ K+DAG Y C+A
Sbjct: 424 GSLVSLDC-KPRASPRALSSWKKGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCMAE 482
Query: 240 NMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDP----------PPRL 289
N G + + ++V E P N V V C+V+ DP L
Sbjct: 483 NQFG-KANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGAL 541
Query: 290 RWRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPP 347
K+DG + S L I ++ + G Y C+ + V ++ L V P
Sbjct: 542 ADFKKDGS-HFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRGSP 598
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 194 bits (494), Expect = 4e-49
Identities = 203/802 (25%), Positives = 327/802 (40%), Gaps = 85/802 (10%)
Query: 91 PRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFP---RIVHGRRARPDEGVYTCVARN 147
PRP + W++ G ++ +PS + ++V D G Y A N
Sbjct: 219 PRPQVTWFREGHKI-------------IPSNRIAITLENQLVILATTTSDAGAYYVQAVN 265
Query: 148 YLGAAASRNASLEVAVLRD---------DFRQSPGN-VVVAVGEPAVLECVPP-RGHPEP 196
+ + +++ RD PGN VVA LEC+ R +
Sbjct: 266 EKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDL 325
Query: 197 SVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVAS--NMAGERESAAAEVMV 254
SV+W+++G R+ + G +L +S+ +D G YVC A+ A E A A + +
Sbjct: 326 SVTWKRNGVRITSG---LHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFI 382
Query: 255 LERPSFLRRPVNQVVL-ADAPVTFLCEVKGDPPPRLRWRKED---GELPTGRYEIRSDHS 310
+E P F P +++ + V C+ G P P L+W K+ L RY++ +
Sbjct: 383 IEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGG 442
Query: 311 LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV-HVPPQLVTQPQDQMAAPGESVAFQCE 369
L I + ED G + C A N G + L V ++ P +P D G + +CE
Sbjct: 443 LRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCE 502
Query: 370 TKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSV 429
G P PAI W++E + S S++ RF + G L I V DAG Y C A +
Sbjct: 503 VSGAPKPAITWKRENH---ILASGSVR-IPRFMLLESGGLQIAPVFIQDAGNYTCYAANT 558
Query: 430 AGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVR--WKKD 487
GS+ A A L + + I+ P + ++ G++ L C T +P+ S+R WKKD
Sbjct: 559 EGSLNASATLTVWNRTS------IVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKD 612
Query: 488 GQWLQGDDL-QFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSP 546
L + +G+L I+ D+G YSC S G + L++ E
Sbjct: 613 NVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIE------ 666
Query: 547 DPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVA 606
P SP P + +++ L+W + + Y++E + W+
Sbjct: 667 ----LPHSPQNLLVSPNSSH--SHAVVLSWVRPFDGNSPILYYIVELSEN--NSPWKVHL 718
Query: 607 DGV--QLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWRG 664
V ++ TVSGL P Y F V AV G + S + + + PS P ++
Sbjct: 719 SNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVAS 778
Query: 665 QQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAGPEGGSWTMLDLQSP 724
+ + V+ Q P P T +++G+ + +R+AG G + ++ SP
Sbjct: 779 GRTNQSIMVQWQPP----PETEHNG--------VLRGYILRYRLAGLPG-EYQQRNITSP 825
Query: 725 SQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGN 784
++ L TQ +I+V A GLG S +VT + P+ PPQ V +
Sbjct: 826 EVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTE--AVNS 883
Query: 785 SSITVSWEPPLPSQQNGVITEYQI--WCLGNESRFHLNRSAAGW--ARSAMLRGLVPGLL 840
++I W PP NG+ Y++ W + A + + L
Sbjct: 884 TTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTA 943
Query: 841 YRTLVAAATSAGVGVPSAPVLV 862
Y T V T+ G G PS P LV
Sbjct: 944 YFTSVLCFTTPGDGPPSTPQLV 965
Score = 178 bits (452), Expect = 3e-44
Identities = 199/817 (24%), Positives = 323/817 (39%), Gaps = 109/817 (13%)
Query: 78 GEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPD 137
G L C AEG +W ++ + + T + ++ ++PS + D
Sbjct: 119 GNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSE---YKYIIPS------------LQKLD 163
Query: 138 EGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPS 197
G Y CV RN +GA R + ++VA + F + V+ G A+L +P +P P
Sbjct: 164 AGFYRCVVRNRMGALLQRKSEVQVAYM-GSFMDTDQRKTVSQGRAAILNLLPITSYPRPQ 222
Query: 198 VSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMA-GERESAAAEVMVLE 256
V+W ++G ++ +L++ T SDAG Y A N GE +++ + +
Sbjct: 223 VTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIA 282
Query: 257 R---------PSFLRRPVNQVVLADAPVTFL-CEVKGDPPPRLR--WRKEDGELPTGRYE 304
R P+ + P N+ V+A + T L C P L W++ + +G +
Sbjct: 283 RDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHS 342
Query: 305 IRSDHSLWIGHVSAEDEGTYTCVAE---NSVGRAEASGSLSVHVPPQLVTQPQDQMAAP- 360
L I + ++ D G Y C A ++ A A+ L + PP +P+ +++A
Sbjct: 343 F--GRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEV 400
Query: 361 GESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAG 420
E+V C+ G P P + W K+ + S R+ V G L I ++ D+G
Sbjct: 401 EETVDIGCQAMGVPLPTLQWYKDAISI------SRLQNPRYKVLASGGLRIQKLRPEDSG 454
Query: 421 YYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQP 480
+ C A + G I L++ + PV Q P + T+ G + L C V+G P+P
Sbjct: 455 IFQCFASNEGGEIQTHTYLDVTN-----IAPVFTQRPVDTTVTDGMTAILRCEVSGAPKP 509
Query: 481 SVRWKKDGQWLQGDDL---QFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLK 537
++ WK++ L + +F + +G L IA V D G Y+C A ++ G S L
Sbjct: 510 AITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLT 569
Query: 538 MREDWGVSPDPP-------TEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYV 590
+ + P T + GA P V S+ WK +
Sbjct: 570 VWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRV------SLRYVWKKDN---------- 613
Query: 591 IEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQ 650
A +P++ + DG L + T SG +G + VSE
Sbjct: 614 -VALTPSSTSRIVVEKDGSLLISQTWSG------------DIGDYSC---EIVSEGGNDS 657
Query: 651 DSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWT--VDGPVQLVQGFRVSWRV 708
+ +E P Q L +VL SW DG ++ + V
Sbjct: 658 RMARLEVIELPHSPQNLLVSPNSSHSHAVVL-------SWVRPFDGNSPILY-----YIV 705
Query: 709 AGPEGGS-WTM-LDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTR-SIPE 765
E S W + L P + GL P Q +V A + G G S +R +PE
Sbjct: 706 ELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPE 765
Query: 766 EAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEY--QIWCLGNESRFHLNRSA 823
E PS PP+ + + G N SI V W+PP ++ NGV+ Y + G +
Sbjct: 766 EPPSAPPKNIVAS--GRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNIT 823
Query: 824 AGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPV 860
+ ++ L+ Y VAA AG+GV S V
Sbjct: 824 SPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAV 860
Score = 149 bits (376), Expect = 2e-35
Identities = 210/851 (24%), Positives = 321/851 (37%), Gaps = 103/851 (12%)
Query: 59 PEDAMPRIVEQPPDLLVSRGEP-ATLPCRAEGRPRPNIE--WYKNGARVATVREDPRAHR 115
PE P IV P + V G TL C A RP ++ W +NG R+ +
Sbjct: 288 PETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHS----- 342
Query: 116 LLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDD-FRQSPGN 174
F R+ D G Y C A A A+ + ++ F P +
Sbjct: 343 --------FGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPES 394
Query: 175 VVVAVGEPAVLECVPPRGHPEPSVSWRKDG---ARLKEEEGRITIRGGKLMMSHTLKSDA 231
+ A E V G P P++ W KD +RL+ ++ GG L + D+
Sbjct: 395 RISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGG-LRIQKLRPEDS 453
Query: 232 GMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRW 291
G++ C ASN GE ++ + P F +RPV+ V CEV G P P + W
Sbjct: 454 GIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITW 513
Query: 292 RKEDGELPTG-----RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVP 346
++E+ L +G R+ + L I V +D G YTC A N+ G AS +L+V
Sbjct: 514 KRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNR 573
Query: 347 PQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPR 406
+V P+D + G + C +P ++ + + V L PS T R V
Sbjct: 574 TSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSS----TSRIVVEKD 629
Query: 407 GQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGP---ANQTLV 463
G L I+ GD G Y C+ VS G+ A LE+ L P +L P + +V
Sbjct: 630 GSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEV--IELPHSPQNLLVSPNSSHSHAVV 687
Query: 464 L-------GSS--VWLPCRVTGNPQP-SVRWKKDGQWLQGDDLQFKTMANGTLY-IANVQ 512
L G+S ++ ++ N P V G + G + T A + + V
Sbjct: 688 LSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVN 747
Query: 513 EMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTE-ITKNS 571
E+ G YS A++S L + P PP AP + +V T S
Sbjct: 748 EVGRGQYS--AETSR--------LML-------------PEEPPSAPPKNIVASGRTNQS 784
Query: 572 ITLTWKPNPQT--GAAVTSYVIE-AFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFL 628
I + W+P P+T + Y++ + G + ++ V+ L T Y
Sbjct: 785 IMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQ 844
Query: 629 VRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQV 688
V A GL V T+ + P P Q + AV T+Q
Sbjct: 845 VAAYNGAGLG----VFSRAVTEYTLQGVPTAPP----QNVQTEAV--------NSTTIQF 888
Query: 689 SWTVDGPVQLVQGFR-----VSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIK 743
W P Q + G ++W PE + + + L T
Sbjct: 889 LWN-PPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTS 947
Query: 744 VQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVI 803
V G G S E+ P ++ ++S+ VSW+ PL ++NG+I
Sbjct: 948 VLCFTTPGDGPPSTPQLVWTQEDKPGAVGH---LSFTEILDTSLKVSWQEPL--EKNGII 1002
Query: 804 TEYQI-WCLGNESRFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLV 862
T YQI W + + L + ++GL Y VAA T+ G G+ ++ +
Sbjct: 1003 TGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSST-I 1061
Query: 863 QLPSPPDLEPG 873
PPDL PG
Sbjct: 1062 SSGVPPDL-PG 1071
Score = 81.6 bits (200), Expect = 5e-15
Identities = 154/704 (21%), Positives = 257/704 (36%), Gaps = 110/704 (15%)
Query: 258 PSFLRRP-VNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDHSLWIGHV 316
P F P + Q+ L + C +G P +W ++D EL T S++ I +
Sbjct: 104 PYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTT----YSSEYKYIIPSL 159
Query: 317 SAEDEGTYTCVAENSVGR-AEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQ-CETKGNP 374
D G Y CV N +G + + V + Q + + G + P
Sbjct: 160 QKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYP 219
Query: 375 PPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVA-GSI 433
P + W +EG +++ P+ R +++ QL I A DAG Y QAV+ G
Sbjct: 220 RPQVTWFREGHKII--------PSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGEN 271
Query: 434 LAKALLEIKGASLDGLP----PVILQGPANQTLVLGSS-VWLPCRVTGNP--QPSVRWKK 486
+ + A G P P I+ P N+++V GSS L C + P SV WK+
Sbjct: 272 KTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKR 331
Query: 487 DGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAK---SSTGEATWSGWLKMREDWG 543
+G + F L I+N D G Y C A S+ A + +L + E
Sbjct: 332 NGVRITSGLHSF----GRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPY 387
Query: 544 VSPDPPTEPSSPP--------GAPSQPVVT-EITKNSITLTWKPNPQTGAAVTSYV-IEA 593
+ +P + S+ A P+ T + K++I+++ NP+ + + I+
Sbjct: 388 FTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQK 447
Query: 594 FSPAAGNTWRTVA--DGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQD 651
P ++ A +G +++THT + N +F R V + ++ +R +
Sbjct: 448 LRPEDSGIFQCFASNEGGEIQTHTYLDV-TNIAPVFTQRPVDT---TVTDGMTAILRCEV 503
Query: 652 SSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAGP 711
S +P R LA +VR+ ++L LQ++ PV + + A
Sbjct: 504 SGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIA-----PVFIQDAGNYTCYAANT 558
Query: 712 EGG--------SWTMLDLQSPSQQSTVLRG---------------------------LPP 736
EG W + P + V++G L P
Sbjct: 559 EGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTP 618
Query: 737 GTQIQIKVQAQGQ------------------EGLGAESLSVTRSIPEEAPSGPPQGVAVA 778
+ +I V+ G G + R E P PQ + V+
Sbjct: 619 SSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHS-PQNLLVS 677
Query: 779 LGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGWARSAM-LRGLVP 837
+ ++ +SW P N I Y + N S + ++ S G + + + GL P
Sbjct: 678 PNSSHSHAVVLSWVRPFDG--NSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTP 735
Query: 838 GLLYRTLVAAATSAGVGVPSAPV--LVQLPSPPDLEPGLEVGAG 879
Y+ V A G G SA L+ PP P V +G
Sbjct: 736 ARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASG 779
Score = 79.0 bits (193), Expect = 3e-14
Identities = 86/340 (25%), Positives = 145/340 (42%), Gaps = 47/340 (13%)
Query: 552 PSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNT--WRTV---- 605
P PGAPS V++ I+ S TL ++P +++ +++E A G+ W T+
Sbjct: 1066 PPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEE 1125
Query: 606 --ADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWR 663
D LE + L P T Y F ++ V G S SP S ++T + P
Sbjct: 1126 NEPDAQMLE---IPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPD-------- 1174
Query: 664 GQQGLAEVAVRLQEPIVLGPRTLQVSWT------VDGPVQLVQGFRVSWRVAGPEGGSWT 717
+A +V ++ +L++ W +G + V G+R+ + + + +
Sbjct: 1175 ----VAPTSVTVR---TASETSLRLRWVPLPDSQYNGNPESV-GYRIKYWRSDLQSSAVA 1226
Query: 718 MLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAV 777
+ ++ T+ L + ++++QA G G S V E PS P+ V+
Sbjct: 1227 QVVSDRLEREFTI-EELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSA 1285
Query: 778 ALGGDGNSSITVSWEPPLPSQQNGVITEYQIWC----LGNESRFHLNRSAAGWARSAMLR 833
++ I ++W QNG+I Y+I L E R H+ R +SA+L
Sbjct: 1286 E--AVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRG--NHTQSALLA 1341
Query: 834 GLVPGLLYRTLVAAATSAGVGVPSAPVLVQ-----LPSPP 868
GL +LY V A T G GVPS P++++ P PP
Sbjct: 1342 GLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPP 1381
Score = 75.1 bits (183), Expect = 4e-13
Identities = 190/814 (23%), Positives = 292/814 (35%), Gaps = 165/814 (20%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
P ++P D V+ G A L C G P+P I W + +A+ LL G
Sbjct: 480 PVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQ 539
Query: 124 FFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVL-RDDFRQSPGNVVVAVGEP 182
P + D G YTC A N G S NAS + V R P + VV G
Sbjct: 540 IAPVFIQ------DAGNYTCYAANTEG---SLNASATLTVWNRTSIVHPPEDHVVIKGTT 590
Query: 183 AVLECVPPRGHPEPSVS----WRKDGARLKEEE-GRITI-RGGKLMMSHTLKSDAGMYVC 236
A L C +P VS W+KD L RI + + G L++S T D G Y C
Sbjct: 591 ATLHCGATH---DPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSC 647
Query: 237 VASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRW-RKED 295
+ G +S A + V+E P P N +V ++ + L W R D
Sbjct: 648 EIVSEGGN-DSRMARLEVIELP---HSPQNLLVSPNSSHSHAVV--------LSWVRPFD 695
Query: 296 GELPTGRY--EIRSDHSLWIGHVS---AEDEGT------------YTCVAENSVGRAEAS 338
G P Y E+ ++S W H+S E G + A N VGR + S
Sbjct: 696 GNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYS 755
Query: 339 GSLS-VHVPPQLVTQPQDQMAAPG---ESVAFQCETKGNPPPAIFWQKEGSQVL---LFP 391
S + +P + + P + A G +S+ Q + PPP + E + VL +
Sbjct: 756 AETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQ----PPP----ETEHNGVLRGYILR 807
Query: 392 SQSLQPTGRFSVSPRGQLNITAVQRGDA--------GYYVCQAVSVAGS---ILAKALLE 440
+ G + Q NIT+ + Y Q + G+ + ++A+ E
Sbjct: 808 YRLAGLPGEYQ-----QRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTE 862
Query: 441 IKGASLDGLPPVILQGPA-NQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFK 499
+ PP +Q A N T + +W NP P Q++ G + +K
Sbjct: 863 YTLQGVPTAPPQNVQTEAVNSTTI--QFLW-------NPPPQ-------QFINGINQGYK 906
Query: 500 TMA------------------NGTLY--IANVQEMDMGFYSCVAKSSTGEATWSGWLKMR 539
+A +G + I N+++ F S + ++ G+ S
Sbjct: 907 LLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPS------ 960
Query: 540 EDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAG 599
+P PGA TEI S+ ++W+ + +T Y I
Sbjct: 961 -----TPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRN 1015
Query: 600 NTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGA--WGLSEPSPVSEPVRTQ-DSSPSR 656
++ T + + GL T Y V AV A GL S +S V +PS
Sbjct: 1016 DSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSN 1075
Query: 657 PVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAGPEGG-- 714
V ++ ++ R TLQ DG + + W V G G
Sbjct: 1076 LV---------ISNISPR--------SATLQFRPGYDGKTSISR-----WIVEGQVGAIG 1113
Query: 715 ---SWTML--DLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLS--VTRSIPEEA 767
W L + P Q + L P T + +++ G S S V +++ +
Sbjct: 1114 DEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTL-QAP 1172
Query: 768 PSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNG 801
P P V V + +S+ + W P SQ NG
Sbjct: 1173 PDVAPTSVTVRTASE--TSLRLRWVPLPDSQYNG 1204
Score = 67.4 bits (163), Expect = 9e-11
Identities = 85/353 (24%), Positives = 136/353 (38%), Gaps = 45/353 (12%)
Query: 537 KMREDWGVSPDPP---TEPSSPPGAPSQPVV--TEITKNSITLTWKPNPQTGAAVTSYVI 591
K R+ WG + TE P P + +V E+T S+ L W P + + + +
Sbjct: 1455 KTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTM 1514
Query: 592 EAFSPAAGNTWRTVADGVQLETHT--VSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRT 649
+ G W+T + + E V L+P T Y ++A G S+ S +E V T
Sbjct: 1515 QVRELPRGE-WQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTT 1573
Query: 650 QDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVA 709
P P + V ++ Q P +++G L+QG+R+ +R
Sbjct: 1574 LQDVPGEPPGSVSATPHTTSSVLIQWQPPR---------DESLNG---LLQGYRIYYREL 1621
Query: 710 GPEGGSWTML-----------DLQSPSQQSTV----------LRGLPPGTQIQIKVQAQG 748
E GS T +L + S TV L L + ++ + A
Sbjct: 1622 EYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYN 1681
Query: 749 QEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQI 808
G S V + E AP+ PQ V V S + V+W+PP P QNG I Y+I
Sbjct: 1682 IIGESPASAPVEVFVGEAAPAMAPQNVQVT--PLTASQLEVTWDPPPPESQNGNIQGYKI 1739
Query: 809 WCLGNESRFHLNRSAAGWARSAM--LRGLVPGLLYRTLVAAATSAGVGVPSAP 859
+ +S+ + + + L+ L Y ++A +AG G S P
Sbjct: 1740 YYWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDP 1792
Score = 63.2 bits (152), Expect = 2e-09
Identities = 60/260 (23%), Positives = 107/260 (41%), Gaps = 26/260 (10%)
Query: 556 PGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIE-AFSPAAGNTWRTVADGVQLETH 614
PG P + V E+ S+ + W+P + + Y I + ++ +T+ TV G +
Sbjct: 1378 PGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQF 1437
Query: 615 TVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVR 674
T + L P + Y+F + A G EP + + P+ P E
Sbjct: 1438 TATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRE--------------L 1483
Query: 675 LQEPIVLGPRTLQVSWT--VDGPVQLVQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTVLR 732
L + R+L++ W DG ++ F + R P G T S + V+
Sbjct: 1484 LVPQAEVTARSLRLQWVPGSDG-ASPIRYFTMQVREL-PRGEWQTYSSSISHEATACVVD 1541
Query: 733 GLPPGTQIQIKVQAQ---GQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITV 789
L P T +++++A G +E+ +VT ++ P PP V+ SS+ +
Sbjct: 1542 RLRPFTSYKLRLKATNDIGDSDFSSETEAVTTL--QDVPGEPPGSVSAT--PHTTSSVLI 1597
Query: 790 SWEPPLPSQQNGVITEYQIW 809
W+PP NG++ Y+I+
Sbjct: 1598 QWQPPRDESLNGLLQGYRIY 1617
Score = 46.2 bits (108), Expect = 2e-04
Identities = 78/335 (23%), Positives = 125/335 (37%), Gaps = 44/335 (13%)
Query: 556 PGAPSQPVVTE-ITKNSITLTWKPNPQT-------GAAVTSYVIEAFSPAAGNTWRTVAD 607
P AP Q V TE + +I W P PQ G + ++ +A P A D
Sbjct: 869 PTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADA--PEAVTVVTIAPD 926
Query: 608 GVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWRGQQG 667
+ ++ L+ T Y V G PS + V TQ+ P G
Sbjct: 927 FHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPS-TPQLVWTQEDKPGAV------GHLS 979
Query: 668 LAEVAVRLQEPIVLGPRTLQVSWTVDGPVQ---LVQGFRVSWRVAGPEGGSWTMLDLQSP 724
E+ +L+VSW P++ ++ G+++SW V G T L S
Sbjct: 980 FTEIL----------DTSLKVSW--QEPLEKNGIITGYQISWEVYGRNDSRLTHT-LNST 1026
Query: 725 SQQSTVLRGLPPGTQIQIKVQAQGQEGLG-AESLSVTRSIPEEAPSGPPQGVAVALGGDG 783
+ + + +GL T I V A G G S +++ +P + P P + +
Sbjct: 1027 THEYKI-QGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSN---LVISNIS 1082
Query: 784 NSSITVSWEPPLPSQQN--GVITEYQIWCLGNESRFHLNRSAAGWARSAMLR--GLVPGL 839
S T+ + P + + I E Q+ +G+E + + ML L P
Sbjct: 1083 PRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYT 1142
Query: 840 LYRTLVAAATSAGVGV--PSAPVLVQLPSPPDLEP 872
YR + G PS+ V+ L +PPD+ P
Sbjct: 1143 HYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAP 1177
Score = 45.4 bits (106), Expect = 4e-04
Identities = 55/275 (20%), Positives = 106/275 (38%), Gaps = 31/275 (11%)
Query: 523 AKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNP-- 580
A ++ G WS ++ R T S P AP ++ I LTW P
Sbjct: 1254 AFNAVGAGPWSEVVRGR----------TRESVPSAAPENVSAEAVSSTQILLTWTSVPEQ 1303
Query: 581 -QTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSE 639
Q G + ++ + G ++ ++GL+ +Y V A G
Sbjct: 1304 DQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGV 1363
Query: 640 PSPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSW-TVDGPVQL 698
PS RT+D +P PV L VRL ++++ W + P +
Sbjct: 1364 PSTPLILERTKDDAPGPPVR--------LVFPEVRL--------TSVRIVWQPPEEPNGI 1407
Query: 699 VQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLS 758
+ G+++++R+A ++T +++ + +Q T L P + ++ A+ ++G G +
Sbjct: 1408 ILGYQIAYRLASSSPHTFTTVEVGATVRQFTA-TDLAPESAYIFRLSAKTRQGWGEPLEA 1466
Query: 759 VTRSIPEEAPSGPPQGVAVALGGDGNSSITVSWEP 793
+ + PP+ + V S+ + W P
Sbjct: 1467 TVITTEKRERPAPPRELLVPQAEVTARSLRLQWVP 1501
Score = 41.2 bits (95), Expect = 0.007
Identities = 49/177 (27%), Positives = 69/177 (38%), Gaps = 25/177 (14%)
Query: 502 ANGTLYIANVQEMDMGFYSCVAKSSTGEA--TWSGWLKMRE-DWGVS------------- 545
ANG L V + V+K T E W WLK+R+ GV+
Sbjct: 1828 ANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYG 1887
Query: 546 PDPPTEPSSPP--GAPSQPVVTEITKNS--ITLTWKPNPQTGAAVTSYVIEAFSPAAGNT 601
P+ ++ P G+P P +TK++ +TL W T YVIEA P+
Sbjct: 1888 PELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEA-RPSDEGL 1946
Query: 602 W----RTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSP 654
W + + T ++ L+ Y F V AV G EPS S V Q +P
Sbjct: 1947 WDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 193 bits (491), Expect = 8e-49
Identities = 205/777 (26%), Positives = 310/777 (39%), Gaps = 100/777 (12%)
Query: 137 DEGVYTCVARNYLGAAA----SRNASLEVAVLRDDFR--------QSPGNVVVAVGEPAV 184
D G Y+C+A +++ + S+ A L +A +D R + P VG+
Sbjct: 201 DLGNYSCLATSHMDFSTKSVFSKFAQLNLAA--EDTRLFAPSIKARFPAETYALVGQQVT 258
Query: 185 LECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGE 244
LEC G+P P + WRK L + T L + D G Y C A N G
Sbjct: 259 LECFA-FGNPVPRIKWRKVDGSLSPQW---TTAEPTLQIPSVSFEDEGTYECEAENSKG- 313
Query: 245 RESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT-GRY 303
R++ ++V +P +L+ + + + + C G P P +RW + L + R
Sbjct: 314 RDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRV 373
Query: 304 EIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVH-VPPQLVTQPQDQM--AAP 360
E+ + L +S ED G Y CVAEN G AS L+V + P P ++ AA
Sbjct: 374 EVLAG-DLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAAR 432
Query: 361 GESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAG 420
G + C+ + P + W K G+++L+ S R +V+P G L I + R D G
Sbjct: 433 GGEILIPCQPRAAPKAVVLWSK-GTEILVNSS-------RVTVTPDGTLIIRNISRSDEG 484
Query: 421 YYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQP 480
Y C A + G + +L ++ A+ I P++ + LG ++ L C + +P
Sbjct: 485 KYTCFAENFMGKANSTGILSVRDATK------ITLAPSSADINLGDNLTLQCHASHDPTM 538
Query: 481 SVRWKKDGQWLQGD-DLQFKTMAN-----------GTLYIANVQEMDMGFYSCVAKSSTG 528
+ + W D + F G L I N Q G Y+C+A++
Sbjct: 539 DLTFT----WTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVD 594
Query: 529 EATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTS 588
A+ + +R PPG P VV +I +I L+W + +
Sbjct: 595 SASKEATVLVR--------------GPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAK 640
Query: 589 YVIEAFSPAAGNTWRTVADGV-----QLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPV 643
Y ++A +P AG W+ V ET V GL P Y F V A G EPS
Sbjct: 641 YTLQARTPPAGK-WKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGP 699
Query: 644 SEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWT-VDGPVQLVQGF 702
S +RT++++PS G G P L V+WT + Q GF
Sbjct: 700 SSKIRTREAAPS-VAPSGLSGGGG--------------APGELIVNWTPMSREYQNGDGF 744
Query: 703 RVSWRVAGPEGGSWTMLDLQSPSQQSTVL--RGLPPGTQIQIKVQAQGQEGLGAESLSVT 760
W + Q V + P T ++K+++ + G G ESL+
Sbjct: 745 GYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTAL 804
Query: 761 RSIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQI--WCLGNESRFH 818
EE P P V G +S + V+WEP + NG++ Y+I W G++
Sbjct: 805 VYSAEEEPRVAPTKVWAK--GVSSSEMNVTWEP-VQQDMNGILLGYEIRYWKAGDKEAAA 861
Query: 819 LNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVG--VPSAPVLVQLPSPPDLEPG 873
AG SA + GL P Y V A AG G PSA P PP PG
Sbjct: 862 DRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKP-PPRRPPG 917
Score = 181 bits (459), Expect = 4e-45
Identities = 211/771 (27%), Positives = 316/771 (40%), Gaps = 99/771 (12%)
Query: 64 PRIVEQPPDLLV---SRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPS 120
P +QP +L S E L CRA P W NG + E H+L+
Sbjct: 37 PVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNGTEMKL--EPGSRHQLV--G 92
Query: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVG 180
G L I++ +A+ D GVY C+A N +G SR A L L++ ++ V G
Sbjct: 93 GNLV---IMNPTKAQ-DAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEG 148
Query: 181 EPAVLECVPPRGHPEPSVSWR-KDGARLKEEEGR--ITIRGGKLMMSHTLKSDAGMYVCV 237
+L C PP +P S W + +GR ++ G L ++ T SD G Y C+
Sbjct: 149 WGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCL 208
Query: 238 A-SNMAGERESA---------AAEVMVLERPSFLRR-PVNQVVLADAPVTFLCEVKGDPP 286
A S+M +S AAE L PS R P L VT C G+P
Sbjct: 209 ATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPV 268
Query: 287 PRLRWRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVP 346
PR++WRK DG L ++ +L I VS EDEGTY C AENS GR G + V
Sbjct: 269 PRIKWRKVDGSLSP--QWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQ 326
Query: 347 PQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPR 406
P+ + D A G ++ + C G P P + W + G + L R V
Sbjct: 327 PEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNG--------EPLASQNRVEVL-A 377
Query: 407 GQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLD-GLPPVILQGPANQTLVLG 465
G L + + D+G Y C A + G+I A A L ++ + D L PV PA + G
Sbjct: 378 GDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAAR----G 433
Query: 466 SSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKS 525
+ +PC+ P+ V W K G + + + +GTL I N+ D G Y+C A++
Sbjct: 434 GEILIPCQPRAAPKAVVLWSK-GTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAEN 492
Query: 526 STGEATWSGWLKMREDWGVSPDPPT-EPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGA 584
G+A +G L +R+ ++ P + + + Q + +T TW
Sbjct: 493 FMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTW-------- 544
Query: 585 AVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVS 644
+ + I+ F G+ RT T+ L TI +R G +
Sbjct: 545 TLDDFPID-FDKPGGHYRRTNV------KETIGDL---TILNAQLRHGGKYTCM------ 588
Query: 645 EPVRTQDSSPSRPVEDPWRGQQG-LAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGF- 702
+T S S+ RG G V VR +G T+Q+SW+ +GF
Sbjct: 589 --AQTVVDSASKEATVLVRGPPGPPGGVVVR-----DIGDTTIQLSWS--------RGFD 633
Query: 703 ------RVSWRVAGPEGGSWTML-----DLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEG 751
+ + + P G W + +++ ++ + VL GL P + +V A G
Sbjct: 634 NHSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVL-GLTPWMDYEFRVIASNILG 692
Query: 752 LGAESLSVTR-SIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNG 801
G S ++ E APS P G++ GG + V+W P QNG
Sbjct: 693 TGEPSGPSSKIRTREAAPSVAPSGLSG--GGGAPGELIVNWTPMSREYQNG 741
Score = 134 bits (336), Expect = 8e-31
Identities = 175/771 (22%), Positives = 294/771 (38%), Gaps = 99/771 (12%)
Query: 70 PPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIV 129
P + G+ TL C A G P P I+W K ++ P P +
Sbjct: 246 PAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLS-------------PQWTTAEPTLQ 292
Query: 130 HGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVP 189
+ DEG Y C A N G + + A + ++ + + +G C
Sbjct: 293 IPSVSFEDEGTYECEAENSKGRDTVQGRIIVQA--QPEWLKVISDTEADIGSNLRWGCAA 350
Query: 190 PRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAA 249
G P P+V W ++G L + R+ + G L S D+GMY CVA N G ++A
Sbjct: 351 A-GKPRPTVRWLRNGEPLASQN-RVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASA 408
Query: 250 AEVMVLERPSFLRRPVNQVVLA--DAPVTFLCEVKGDPPPRLRWRKEDGELP-TGRYEIR 306
+ P F PV +++ A + C+ + P + W K L + R +
Sbjct: 409 ELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVT 468
Query: 307 SDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAF 366
D +L I ++S DEG YTC AEN +G+A ++G LSV ++ P G+++
Sbjct: 469 PDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTL 528
Query: 367 QCETKGNPPPAIF--WQKEGSQVLLFPSQSLQPTGRFSVS----PRGQLNITAVQRGDAG 420
QC +P + W + FP +P G + + G L I Q G
Sbjct: 529 QCHASHDPTMDLTFTWTLDD-----FPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGG 583
Query: 421 YYVCQAVSVAGSILAKALLEIKGASLDGLPP--VILQGPANQTLVLGSSVWLPCRVTGNP 478
Y C A +V S +A + ++G PP V+++ + T+ L S R N
Sbjct: 584 KYTCMAQTVVDSASKEATVLVRGPPG---PPGGVVVRDIGDTTIQLSWS-----RGFDNH 635
Query: 479 QPSVRWKKD------GQWLQ--GDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEA 530
P ++ G+W Q + + A + MD F +A + G
Sbjct: 636 SPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEF-RVIASNILGTG 694
Query: 531 TWSG-WLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNP---QTGAAV 586
SG K+R P+ S GAP + +V W P Q G
Sbjct: 695 EPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVN----------WTPMSREYQNGDGF 744
Query: 587 TSYVIEAFSPAAGNTWRTV----ADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSP 642
Y++ +F W+T AD Q ++ ++P T + +R+ G P
Sbjct: 745 -GYLL-SFRRQGSTHWQTARVPGADA-QYFVYSNESVRPYTPFEVKIRSYNRRG-DGPES 800
Query: 643 VSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQ----- 697
++ V + + P W +E + V+W PVQ
Sbjct: 801 LTALVYSAEEEPRVAPTKVWAKGVSSSE---------------MNVTWE---PVQQDMNG 842
Query: 698 LVQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESL 757
++ G+ + + AG + + + + V GL P T+ + V+A + G G S
Sbjct: 843 ILLGYEIRYWKAGDKEAAADRVRTAGLDTSARV-SGLHPNTKYHVTVRAYNRAGTGPASP 901
Query: 758 SVTRSIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQI 808
S + + P PP ++ +SS+++ W+P +P + +T Y++
Sbjct: 902 SANATTMKPPPRRPPGNISWTF---SSSSLSIKWDPVVPFRNESAVTGYKM 949
Score = 97.8 bits (242), Expect = 6e-20
Identities = 155/635 (24%), Positives = 234/635 (36%), Gaps = 83/635 (13%)
Query: 62 AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSG 121
A P ++ D G C A G+PRP + W +NG +A+ +R+ + +G
Sbjct: 325 AQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLAS------QNRVEVLAG 378
Query: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGN--VVVAV 179
L F ++ + D G+Y CVA N G + +A L V L DFR +P + A
Sbjct: 379 DLRFSKL-----SLEDSGMYQCVAENKHGTIYA-SAELAVQALAPDFRLNPVRRLIPAAR 432
Query: 180 GEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIR-GGKLMMSHTLKSDAGMYVCVA 238
G ++ C PR P+ V W K G + R+T+ G L++ + +SD G Y C A
Sbjct: 433 GGEILIPC-QPRAAPKAVVLWSK-GTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFA 490
Query: 239 SNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRL--RWRKEDG 296
N G+ S + V + P + + +T C DP L W +D
Sbjct: 491 ENFMGKANSTGI-LSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDF 549
Query: 297 EL----PTGRYEIRSDHSLWIG-----HVSAEDEGTYTCVAENSVGRAEASGSLSVHVPP 347
+ P G Y R++ IG + G YTC+A+ V A ++ V PP
Sbjct: 550 PIDFDKPGGHYR-RTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPP 608
Query: 348 QLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQ----PTGRFSV 403
PG V G+ + W + +LQ P G++
Sbjct: 609 ----------GPPGGVVV---RDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQ 655
Query: 404 SPRGQLNI-----TAVQRGDAGYYVCQAVSVAGSILAKALLEIKGAS-----LDGLPPVI 453
NI TA G + + +A +IL E G S + P V
Sbjct: 656 VRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTG--EPSGPSSKIRTREAAPSVA 713
Query: 454 LQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQE 513
G L P + N P R ++G G L F+ + A V
Sbjct: 714 PSG-------LSGGGGAPGELIVNWTPMSREYQNGDGF-GYLLSFRRQGSTHWQTARVPG 765
Query: 514 MDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPT-----EPSSPPGAPSQPVVTEIT 568
D ++ +S + ++ G P+ T P AP++ ++
Sbjct: 766 ADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVS 825
Query: 569 KNSITLTWKPNPQ-TGAAVTSYVIEAF----SPAAGNTWRTVADGVQLETHT-VSGLQPN 622
+ + +TW+P Q + Y I + AA + RT L+T VSGL PN
Sbjct: 826 SSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAG----LDTSARVSGLHPN 881
Query: 623 TIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRP 657
T Y VRA G SP S T P RP
Sbjct: 882 TKYHVTVRAYNRAGTGPASP-SANATTMKPPPRRP 915
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 185 bits (469), Expect = 3e-46
Identities = 129/417 (30%), Positives = 180/417 (43%), Gaps = 28/417 (6%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDP-RAHRLLLP-SG 121
P++ E P D+ V G A L CRA GRP P + W + + +R R R P SG
Sbjct: 669 PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG 728
Query: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGE 181
LFF + A D+ Y C ARN G + + S V V G+
Sbjct: 729 VLFFESV-----APEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQ 783
Query: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNM 241
P L C+ G P P W KDG L G L + L+ AG Y CVA+N
Sbjct: 784 PVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNT 843
Query: 242 AGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT- 300
AG + E++V P + + P + C G P P + W KE L +
Sbjct: 844 AGS-QHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSR 902
Query: 301 -GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQL-------VTQ 352
Y + + +L I SA+D G Y C A N+VG + LSV+ P++
Sbjct: 903 GPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANV 962
Query: 353 PQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQP-TGRFSVSPRGQLNI 411
P A GE V CE KG+PPP + W K+ S+ + P T R+ + P G L +
Sbjct: 963 PLQVTAKAGEEVTLDCEAKGSPPPLVTWTKD--------SRPVPPITNRYGLLPSGSLRL 1014
Query: 412 TAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSV 468
VQ GD+G+Y C A + AGS + +L ++G + P L P + + G SV
Sbjct: 1015 AQVQVGDSGHYECTASNPAGSASHRYVLGVQGRT--SWQPQSLPVPHHPACLSGLSV 1069
Score = 184 bits (468), Expect = 4e-46
Identities = 145/477 (30%), Positives = 207/477 (43%), Gaps = 47/477 (9%)
Query: 73 LLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGR 132
+LV+ GE A L C A G P P + WY+ G + E + +L +P+
Sbjct: 590 VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQ---------- 639
Query: 133 RARPDEGVYTCVARNYLGAAASRNASLEVAVLR-DDFRQSPGNVVVAVGEPAVLECVPPR 191
D G YTC A N LG A+ A +++AV + P +V V +G A+L C
Sbjct: 640 --ERDAGTYTCRAVNELGDAS---AEIQLAVGHAPQLTELPRDVTVELGRSALLAC-RAT 693
Query: 192 GHPEPSVSWRKD-----GARLKEEEGRITIR--GGKLMMSHTLKSDAGMYVCVASNMAGE 244
G P P+V+WR+ G RL G + + G L D YVC A N+ G+
Sbjct: 694 GRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGK 753
Query: 245 RESAAAEVMVLERPSFLRRPVNQV-VLADAPVTFLCEV-KGDPPPRLRWRKEDGELPTG- 301
++ A ++ P + V VL PV+ C V G P P W K+ LP G
Sbjct: 754 VQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGS 813
Query: 302 RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPG 361
R+ IR+D SL + E G Y+CVA N+ G L V VPP++ + G
Sbjct: 814 RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEG 873
Query: 362 ESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTG-RFSVSPRGQLNITAVQRGDAG 420
+ C G P P I W KE + +L G ++VS G L I DAG
Sbjct: 874 VPASLPCVASGVPAPTITWTKE--------TNALTSRGPHYNVSKEGTLLIAQPSAQDAG 925
Query: 421 YYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVL------GSSVWLPCRV 474
YVC A + G + L S++ P + + G N + L G V L C
Sbjct: 926 AYVCTATNTVGFSSQEMRL-----SVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEA 980
Query: 475 TGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEAT 531
G+P P V W KD + + ++ + +G+L +A VQ D G Y C A + G A+
Sbjct: 981 KGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSAS 1037
Score = 162 bits (411), Expect = 2e-39
Identities = 123/407 (30%), Positives = 182/407 (44%), Gaps = 30/407 (7%)
Query: 132 RRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPG-NVVVAVGEPAVLECVPP 190
R ++ +EG Y C A + A + A ++ V + P NV V+ GE AVL C
Sbjct: 368 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSC-RV 423
Query: 191 RGHPEPSVSWRKDGARLKEEEGRIT-IRGGKLMMSHTLKSDAGMYVCVASNMAGERESAA 249
G +++W +D L GR+ + L +S + +D G Y CVASN G A+
Sbjct: 424 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR-AS 482
Query: 250 AEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT-GRYEIRSD 308
++V E P +Q V C G P P + W +E L R + +
Sbjct: 483 VWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 542
Query: 309 HSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQC 368
+L I V+ ED G Y+C A N VG + + +L PP + + A GE C
Sbjct: 543 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 602
Query: 369 ETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVS 428
E G PPP + W + G +++L P S G+L I A Q DAG Y C+AV+
Sbjct: 603 EASGVPPPRVIWYRGGLEMILAPEG----------SSSGKLRIPAAQERDAGTYTCRAVN 652
Query: 429 VAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKK-D 487
G A+ L + G P + + P + T+ LG S L CR TG P P+V W++ D
Sbjct: 653 ELGDASAEIQLAV------GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGD 706
Query: 488 GQWL-----QGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGE 529
GQ L G + + +G L+ +V D Y C A++ G+
Sbjct: 707 GQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGK 753
Score = 156 bits (394), Expect = 1e-37
Identities = 146/485 (30%), Positives = 203/485 (41%), Gaps = 54/485 (11%)
Query: 61 DAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNG--ARVATVREDPRAHRLLL 118
D P++V P ++ VS GE A L CR G N+ W ++ +T R A L
Sbjct: 398 DPPPQLVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLE 456
Query: 119 PSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSP------ 172
SG + D G Y CVA N G AS+ + V R++P
Sbjct: 457 ISGII-----------PTDGGRYQCVASNANGVT---RASVWLLV-----REAPQVSIHT 497
Query: 173 GNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAG 232
+ + G + C G+P P +SW ++ L+E+ G L++ DAG
Sbjct: 498 SSQHFSQGVEVKVSC-SASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAG 556
Query: 233 MYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVL--ADAPVTFLCEVKGDPPPRLR 290
Y C A+N G + + + PS VN VVL +CE G PPPR+
Sbjct: 557 NYSCQATNEVG-TDQETVTLYYTDPPSV--SAVNAVVLVAVGEEAVLVCEASGVPPPRVI 613
Query: 291 WRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLV 350
W + E+ E S L I D GTYTC A N +G A A L+V PQL
Sbjct: 614 WYRGGLEMILAP-EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLT 672
Query: 351 TQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLF------PSQSLQPTGRFSVS 404
P+D G S C G PPP + W++ Q L S+S QP
Sbjct: 673 ELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS----- 727
Query: 405 PRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVL 464
G L +V D YVC+A +V G + A+A L + G + PP I ++
Sbjct: 728 --GVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHA----PPQIASSAPTVRVLE 781
Query: 465 GSSVWLPCRV-TGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVA 523
G V LPC V G P P W KDG+ L + A+G+L++ + G YSCVA
Sbjct: 782 GQPVSLPCIVLAGRPLPERHWLKDGRPLPPGS-RHSIRADGSLHLDRALQEHAGRYSCVA 840
Query: 524 KSSTG 528
++ G
Sbjct: 841 TNTAG 845
Score = 99.0 bits (245), Expect = 3e-20
Identities = 77/257 (29%), Positives = 111/257 (43%), Gaps = 17/257 (6%)
Query: 274 PVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDHSLW-IGHVSAEDEGTYTCVAENSV 332
P+ C V P RL+ R+ + L R+ S +S W I S +EGTY C A +
Sbjct: 326 PLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRA 385
Query: 333 GRAEASGSLSV-HVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFP 391
G A + V PPQLV P + +PGE+ C G P + W ++ + P
Sbjct: 386 GTGRAKAQIVVTDPPPQLVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWVRDWR---VLP 441
Query: 392 SQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPP 451
+ TGR + L I+ + D G Y C A + G A L ++ A P
Sbjct: 442 AS----TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREA------P 491
Query: 452 VILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANV 511
+ ++Q G V + C +G P P + W ++ Q LQ +D + A GTL I V
Sbjct: 492 QVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ-EDSRIHVDAQGTLIIQGV 550
Query: 512 QEMDMGFYSCVAKSSTG 528
D G YSC A + G
Sbjct: 551 APEDAGNYSCQATNEVG 567
Score = 62.4 bits (150), Expect = 3e-09
Identities = 43/140 (30%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 401 FSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQ 460
F S I + + G Y C AVS AG+ AKA + + PP ++ P N
Sbjct: 356 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDP-----PPQLVPAP-NV 409
Query: 461 TLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYS 520
T+ G + L CRV G ++ W +D + L + +A+ +L I+ + D G Y
Sbjct: 410 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 469
Query: 521 CVAKSSTGEATWSGWLKMRE 540
CVA ++ G S WL +RE
Sbjct: 470 CVASNANGVTRASVWLLVRE 489
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 185 bits (469), Expect = 3e-46
Identities = 116/370 (31%), Positives = 180/370 (48%), Gaps = 19/370 (5%)
Query: 172 PGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLK-EEEGRITI-RGGKLMMSHTLKS 229
P +V V G C G+P+P + W + L E++ R+ + G LM+ +T +S
Sbjct: 240 PQDVEVPSGNTVYFTC-RAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298
Query: 230 DAGMYVCVASNMAGERESAAAEVMVLE---RPSFLRRPVNQVVLADAPVTFLCEVKGDPP 286
D G+Y C+A N AGE ++ +A + +PSF+ +P + VL T C G P
Sbjct: 299 DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPH 358
Query: 287 PRLRWRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVP 346
P + W +++G G + + L++ +++ D G +TC A NS G +A+ ++ V P
Sbjct: 359 PLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAP 418
Query: 347 PQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPR 406
PQ P+DQ+ +V + CE GNPPP I W K G Q L G+ +V
Sbjct: 419 PQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQ--------LPVEGQHTVLSS 470
Query: 407 GQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGS 466
G L I + D G Y CQAVS G L +K +L V Q P + ++ +G
Sbjct: 471 GTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKAL----AVFTQLPQDTSVEVGK 526
Query: 467 SVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSS 526
++ + C G PQP + W K+G + + +F GTL I + D G Y CVA++S
Sbjct: 527 NINISCHAQGEPQPIITWNKEGVQIT-ESGKFHVDDEGTLTIYDAGFPDQGRYECVARNS 585
Query: 527 TGEATWSGWL 536
G A + +L
Sbjct: 586 FGLAVTNMFL 595
Score = 182 bits (461), Expect = 3e-45
Identities = 125/383 (32%), Positives = 184/383 (48%), Gaps = 24/383 (6%)
Query: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
PRI +P D+ V G CRAEG P+P I W N + + +D R + + G L
Sbjct: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSL-DLEDDTRLN--VFDDGTL 290
Query: 124 FFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVL--RDDFRQSPGNVVVAVGE 181
++ R D+GVY C+ARN G A +++A L + L + F P + V +G
Sbjct: 291 ----MIRNTR-ESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGT 345
Query: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNM 241
LEC+ GHP P ++W +D L+ + R L + + + D G + C A+N
Sbjct: 346 STTLECM-ATGHPHPLITWTRDNG-LELDGSRHVATSSGLYLQNITQRDHGRFTCHANNS 403
Query: 242 AGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT- 300
G + AAA ++V P F P +QVVL + V +LCE G+PPP + W K G+LP
Sbjct: 404 HGTVQ-AAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE 462
Query: 301 GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLV-TQ-PQDQMA 358
G++ + S +L I + D+G Y C A +S+G + S L+V V TQ PQD
Sbjct: 463 GQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSV 522
Query: 359 APGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGD 418
G+++ C +G P P I W KEG Q+ +G+F V G L I D
Sbjct: 523 EVGKNINISCHAQGEPQPIITWNKEGVQI--------TESGKFHVDDEGTLTIYDAGFPD 574
Query: 419 AGYYVCQAVSVAGSILAKALLEI 441
G Y C A + G + L +
Sbjct: 575 QGRYECVARNSFGLAVTNMFLTV 597
Score = 111 bits (278), Expect = 4e-24
Identities = 79/289 (27%), Positives = 121/289 (41%), Gaps = 23/289 (7%)
Query: 247 SAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL---PTGRY 303
S E + P P + V + V F C +G+P P + W + L R
Sbjct: 223 SVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRL 282
Query: 304 EIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSL----SVHVPPQLVTQPQDQMAA 359
+ D +L I + D+G Y C+A NS G A+ ++ S+ P V QPQD
Sbjct: 283 NVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVL 342
Query: 360 PGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDA 419
G S +C G+P P I W ++ L+ G V+ L + + + D
Sbjct: 343 IGTSTTLECMATGHPHPLITWTRD---------NGLELDGSRHVATSSGLYLQNITQRDH 393
Query: 420 GYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQ 479
G + C A + G++ A A + ++ PP P +Q ++ +V C GNP
Sbjct: 394 GRFTCHANNSHGTVQAAANIIVQA------PPQFTVTPKDQVVLEEHAVEWLCEADGNPP 447
Query: 480 PSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTG 528
P + W K G L + Q +++GTL I + D G Y C A SS G
Sbjct: 448 PVIVWTKTGGQLPVEG-QHTVLSSGTLRIDRAAQHDQGQYECQAVSSLG 495
Score = 99.8 bits (247), Expect = 2e-20
Identities = 81/285 (28%), Positives = 120/285 (42%), Gaps = 18/285 (6%)
Query: 62 AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYK-NGARVATVREDPRAHRLLLPS 120
A P V QP D V G TL C A G P P I W + NG + R + S
Sbjct: 328 AKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLEL-------DGSRHVATS 380
Query: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVG 180
L+ I + D G +TC A N G + A+ + F +P + VV +
Sbjct: 381 SGLYLQNI-----TQRDHGRFTCHANNSHGTVQA--AANIIVQAPPQFTVTPKDQVV-LE 432
Query: 181 EPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVA-S 239
E AV G+P P + W K G +L E + G L + + D G Y C A S
Sbjct: 433 EHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVS 492
Query: 240 NMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL- 298
++ ++ S V F + P + V + C +G+P P + W KE ++
Sbjct: 493 SLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQIT 552
Query: 299 PTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV 343
+G++ + + +L I D+G Y CVA NS G A + L+V
Sbjct: 553 ESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTV 597
Score = 60.8 bits (146), Expect = 9e-09
Identities = 42/122 (34%), Positives = 58/122 (47%), Gaps = 19/122 (15%)
Query: 451 PVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQ-GDDLQFKTMANGTLYIA 509
P I P + + G++V+ CR GNP+P + W + L DD + +GTL I
Sbjct: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
Query: 510 NVQEMDMGFYSCVAKSSTGEA-TWSGWLKMREDWGVSPDPPTEPSSPPGAPS---QPVVT 565
N +E D G Y C+A++S GEA T S L+ SS P PS QP T
Sbjct: 294 NTRESDQGVYQCMARNSAGEAKTQSAMLRY--------------SSLPAKPSFVIQPQDT 339
Query: 566 EI 567
E+
Sbjct: 340 EV 341
>gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]
Length = 619
Score = 184 bits (466), Expect = 7e-46
Identities = 151/512 (29%), Positives = 231/512 (45%), Gaps = 37/512 (7%)
Query: 37 LAALNHTLLPPGDPSLNGSRVGPEDAMPRIVEQPP-DLLVSRGEPATLPCRAEGRPRPNI 95
L +L + P DPS+ P P I +Q D +V + + C A+G P P+
Sbjct: 18 LLSLGGAIEIPMDPSIQNELTQP----PTITKQSAKDHIVDPRDNILIECEAKGNPAPSF 73
Query: 96 EWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASR 155
W +N +R + +DPR + SG L G R EG Y C ARN G A S
Sbjct: 74 HWTRN-SRFFNIAKDPRVS-MRRRSGTLVID-FRSGGRPEEYEGEYQCFARNKFGTALSN 130
Query: 156 NASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRIT 215
L+V+ +++ VVV G P L+C PP G P P + W ++ R++
Sbjct: 131 RIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVS 190
Query: 216 I-RGGKLMMSHTLKSDAGM-YVCVA----SNMAGERESAAAEVM----VLER-PSFLR-- 262
G L S+ + D Y C A ++ ++ +V+ V ER PSF+
Sbjct: 191 QGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQ 250
Query: 263 -RPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRS-DHSLWIGHVSAED 320
+Q+VL + C G P P + W K+ G+LP+ + + + + +L I +VS ED
Sbjct: 251 GTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEED 310
Query: 321 EGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFW 380
G Y C+A N +G + S+ V P + +P++ + APGE C GNP P + W
Sbjct: 311 SGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQW 370
Query: 381 QKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLE 440
G P QS P V+ + Q Y C + G +LA A +
Sbjct: 371 MVNGE-----PLQSAPPNPNREVAG-DTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVS 424
Query: 441 IKGASLDGLPPVILQGPANQTL--VLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQF 498
+ LD +PP +L P NQ + +L + L C G+P P++RW K+GQ D +
Sbjct: 425 V----LD-VPPRMLS-PRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNY 478
Query: 499 KTMANGTLYIANVQEMDMGFYSCVAKSSTGEA 530
NG+L I +++ D G Y+CVA + G+A
Sbjct: 479 HVYENGSLEIKMIRKEDQGIYTCVATNILGKA 510
Score = 134 bits (337), Expect = 6e-31
Identities = 116/383 (30%), Positives = 160/383 (41%), Gaps = 41/383 (10%)
Query: 74 LVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRR 133
+V RG L C A G P P+I WYK G LPS F R
Sbjct: 257 MVLRGMDLLLECIASGVPTPDIAWYKKGGD--------------LPSDKAKFENFNKALR 302
Query: 134 ----ARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDF-RQSPGNVVVAVGEPAVLECV 188
+ D G Y C+A N +G S ++ V V + P N+++A GE L C
Sbjct: 303 ITNVSEEDSGEYFCLASNKMG---SIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVC- 358
Query: 189 PPRGHPEPSVSWRKDGARLKEEEGRIT--IRGGKLMMSHTLKSDAGMYVCVASNMAGERE 246
G+P+P+V W +G L+ + G ++ T S +Y C SN G
Sbjct: 359 RANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL- 417
Query: 247 SAAAEVMVLERPSFLRRPVNQV--VLADAPVTFLCEVKGDPPPRLRWRK--EDGELPTGR 302
A A V VL+ P + P NQ+ V+ C G P P LRW K + L G
Sbjct: 418 LANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGN 477
Query: 303 YEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGE 362
Y + + SL I + ED+G YTCVA N +G+AE L V P ++ P+DQ+A G
Sbjct: 478 YHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGT 537
Query: 363 SVAFQCETKGNP--PPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAG 420
+V +C K +P + W K+ + + G L I V D G
Sbjct: 538 TVQLECRVKHDPSLKLTVSWLKDDEPLYI---------GNRMKKEDDSLTIFGVAERDQG 588
Query: 421 YYVCQAVSVAGSILAKALLEIKG 443
Y C A + LAKA L + G
Sbjct: 589 SYTCVASTELDQDLAKAYLTVLG 611
Score = 128 bits (321), Expect = 4e-29
Identities = 126/495 (25%), Positives = 207/495 (41%), Gaps = 48/495 (9%)
Query: 73 LLVSRGEPATLPCRAE-GRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHG 131
++V G P TL C G P P I W + T +D R + +G L+F ++
Sbjct: 150 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPIT--QDKRVSQG--HNGDLYFSNVM-- 203
Query: 132 RRARPDEGVYTCVAR-NYLGAAASRNA-SLEVAVLRDDFRQSPG---------NVVVAVG 180
+ + Y+C AR ++ +N +L+V R ++P + +V G
Sbjct: 204 --LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRG 261
Query: 181 EPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASN 240
+LEC+ G P P ++W K G L ++ + L +++ + D+G Y C+ASN
Sbjct: 262 MDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASN 320
Query: 241 MAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL-- 298
G + V V P +L P N ++ +C G+P P ++W L
Sbjct: 321 KMGSIRHTIS-VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQS 379
Query: 299 --PTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV-HVPPQLVTQPQD 355
P E+ D ++ Y C N G A+ +SV VPP++++ P++
Sbjct: 380 APPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLS-PRN 437
Query: 356 QMAAP--GESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITA 413
Q+ C G+P P + W K G L G + V G L I
Sbjct: 438 QLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL-------DGGNYHVYENGSLEIKM 490
Query: 414 VQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCR 473
+++ D G Y C A ++ G + LE+K P I + P +Q G++V L CR
Sbjct: 491 IRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRIYRMPEDQVARRGTTVQLECR 544
Query: 474 VTGNP--QPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEAT 531
V +P + +V W KD + L + K + +L I V E D G Y+CVA + +
Sbjct: 545 VKHDPSLKLTVSWLKDDEPLYIGNRMKKE--DDSLTIFGVAERDQGSYTCVASTELDQDL 602
Query: 532 WSGWLKMREDWGVSP 546
+L + + SP
Sbjct: 603 AKAYLTVLGNCPCSP 617
>gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]
Length = 1240
Score = 184 bits (466), Expect = 7e-46
Identities = 151/512 (29%), Positives = 231/512 (45%), Gaps = 37/512 (7%)
Query: 37 LAALNHTLLPPGDPSLNGSRVGPEDAMPRIVEQPP-DLLVSRGEPATLPCRAEGRPRPNI 95
L +L + P DPS+ P P I +Q D +V + + C A+G P P+
Sbjct: 18 LLSLGGAIEIPMDPSIQNELTQP----PTITKQSAKDHIVDPRDNILIECEAKGNPAPSF 73
Query: 96 EWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASR 155
W +N +R + +DPR + SG L G R EG Y C ARN G A S
Sbjct: 74 HWTRN-SRFFNIAKDPRVS-MRRRSGTLVID-FRSGGRPEEYEGEYQCFARNKFGTALSN 130
Query: 156 NASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRIT 215
L+V+ +++ VVV G P L+C PP G P P + W ++ R++
Sbjct: 131 RIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVS 190
Query: 216 I-RGGKLMMSHTLKSDAGM-YVCVA----SNMAGERESAAAEVM----VLER-PSFLR-- 262
G L S+ + D Y C A ++ ++ +V+ V ER PSF+
Sbjct: 191 QGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQ 250
Query: 263 -RPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRS-DHSLWIGHVSAED 320
+Q+VL + C G P P + W K+ G+LP+ + + + + +L I +VS ED
Sbjct: 251 GTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEED 310
Query: 321 EGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFW 380
G Y C+A N +G + S+ V P + +P++ + APGE C GNP P + W
Sbjct: 311 SGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQW 370
Query: 381 QKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLE 440
G P QS P V+ + Q Y C + G +LA A +
Sbjct: 371 MVNGE-----PLQSAPPNPNREVAG-DTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVS 424
Query: 441 IKGASLDGLPPVILQGPANQTL--VLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQF 498
+ LD +PP +L P NQ + +L + L C G+P P++RW K+GQ D +
Sbjct: 425 V----LD-VPPRMLS-PRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNY 478
Query: 499 KTMANGTLYIANVQEMDMGFYSCVAKSSTGEA 530
NG+L I +++ D G Y+CVA + G+A
Sbjct: 479 HVYENGSLEIKMIRKEDQGIYTCVATNILGKA 510
Score = 172 bits (435), Expect = 3e-42
Identities = 200/833 (24%), Positives = 328/833 (39%), Gaps = 97/833 (11%)
Query: 73 LLVSRGEPATLPCRAE-GRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHG 131
++V G P TL C G P P I W + T +D R + +G L+F ++
Sbjct: 150 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPIT--QDKRVSQG--HNGDLYFSNVM-- 203
Query: 132 RRARPDEGVYTCVAR-NYLGAAASRNA-SLEVAVLRDDFRQSPG---------NVVVAVG 180
+ + Y+C AR ++ +N +L+V R ++P + +V G
Sbjct: 204 --LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRG 261
Query: 181 EPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASN 240
+LEC+ G P P ++W K G L ++ + L +++ + D+G Y C+ASN
Sbjct: 262 MDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASN 320
Query: 241 MAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL-- 298
G + V V P +L P N ++ +C G+P P ++W L
Sbjct: 321 KMGSIRHTIS-VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQS 379
Query: 299 --PTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV-HVPPQLVTQPQD 355
P E+ D ++ Y C N G A+ +SV VPP++++ P++
Sbjct: 380 APPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLS-PRN 437
Query: 356 QMAAP--GESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITA 413
Q+ C G+P P + W K G L G + V G L I
Sbjct: 438 QLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL-------DGGNYHVYENGSLEIKM 490
Query: 414 VQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCR 473
+++ D G Y C A ++ G + LE+K P I + P +Q G++V L CR
Sbjct: 491 IRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRIYRMPEDQVARRGTTVQLECR 544
Query: 474 VTGNP--QPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEAT 531
V +P + +V W KD + L + K + +L I V E D G Y+CVA + +
Sbjct: 545 VKHDPSLKLTVSWLKDDEPLYIGNRMKKE--DDSLTIFGVAERDQGSYTCVASTELDQDL 602
Query: 532 WSGWLKMREDWGVSPDPPTE-PSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYV 590
+L + D + P P P +T++ + S+ LTW P + +T YV
Sbjct: 603 AKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYV 662
Query: 591 I----EAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEP 646
+ + F P W + V L P Y F V A+ G S PS SE
Sbjct: 663 VQFEEDQFQP---GVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSER 719
Query: 647 VRTQDSSP-SRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFR-- 703
RT + P S P + G + ++++WT P+ F
Sbjct: 720 YRTSGAPPESNPGDVKGEGTR----------------KNNMEITWT---PMNATSAFGPN 760
Query: 704 ----VSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSV 759
V WR +W + + V+ P +I+VQA+ G G E SV
Sbjct: 761 LRYIVKWR-RRETREAWNNVTVWG---SRYVVGQTPVYVPYEIRVQAENDFGKGPEPESV 816
Query: 760 TRSIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCL---GNESR 816
E+ PS P + + +I + W+ P NG++ Y + + G +
Sbjct: 817 IGYSGEDLPSAPRR---FRVRQPNLETINLEWDH--PEHPNGIMIGYTLKYVAFNGTKVG 871
Query: 817 FHLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPD 869
+ + + ++ P YR ++A T G G V + P+PP+
Sbjct: 872 KQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSG---EAVTEESPAPPN 921
>gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens]
Length = 1007
Score = 182 bits (461), Expect = 3e-45
Identities = 150/409 (36%), Positives = 186/409 (45%), Gaps = 46/409 (11%)
Query: 60 EDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLP 119
+D+ P+I+ P D L PA + C+A G+P P I W NG ++ V DP LLP
Sbjct: 28 QDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHH---LLP 84
Query: 120 SGALFF---PRIVH---GRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPG 173
G L P H G+ D GVYTC A N LG A SR A L VAVLR+DF+ P
Sbjct: 85 DGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPR 144
Query: 174 NVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGM 233
++V VGE LEC PP GHPEP+VSW KDG L + GR T+ GG L+M+ KSD G
Sbjct: 145 DMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGT 204
Query: 234 YVCVASNMAGERESAAAEVMVLERPSFLRRPVN--QVVLADAPVTFLCEVKGD-PPPR-- 288
Y+CVA+N AG RES AA V + E P PV V + VT L + P PR
Sbjct: 205 YMCVATNSAGHRESRAARVSIQE-PQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPA 263
Query: 289 --LRWRKEDGELPTGRYE--IRSD-----------HSLWIGHVSAEDEG-----TYTCVA 328
L W+ P Y R+ L G SAE G Y
Sbjct: 264 VWLSWKVSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLHWGQDYEFKV 323
Query: 329 ENSVGRAEA--SGSLSVHVPPQLVT-QPQDQMAAPGESVAFQCETKGNPPPAIFWQK--E 383
S GRA S L + +P ++ + PQ+ PG F PPPA
Sbjct: 324 RPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVF---VSWVPPPAENHNGIIR 380
Query: 384 GSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGS 432
G QV + SL P V + QL I G Y Q +V G+
Sbjct: 381 GYQVWSLGNTSLPPANWTVVGEQTQLEIATHMPGS---YCVQVAAVTGA 426
Score = 152 bits (383), Expect = 3e-36
Identities = 233/964 (24%), Positives = 337/964 (34%), Gaps = 126/964 (13%)
Query: 438 LLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQ----- 492
LL I G PP IL P +Q + C+ +G P P++RW +GQ L
Sbjct: 19 LLLIMGGMAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPD 78
Query: 493 -------GDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGW----LKMRED 541
G L + A G + D+G Y+C A + G A G +RED
Sbjct: 79 PHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRED 138
Query: 542 WGVSP--------DPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEA 593
+ + P + T PP +P V+ K+ L +P T + + + A
Sbjct: 139 FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSW-WKDGKPLALQPGRHTVSGGSLLMARA 197
Query: 594 FSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSS 653
G T+ VA T++ + + + EP +EPV
Sbjct: 198 EKSDEG-TYMCVA------TNSAGHRESRAARV---------SIQEPQDYTEPVE----- 236
Query: 654 PSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQ---------VSWTVDGPVQLVQGFRV 704
L V ++L+ +L P + +SW V GP Q +
Sbjct: 237 --------------LLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTA 282
Query: 705 SWRVA---GPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTR 761
+R G +G W L QS L GL G + KV+ G +S +
Sbjct: 283 LFRTQTAPGGQGAPWAEELLAG--WQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLL 340
Query: 762 SIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNR 821
+PE+ PS PPQ V + GN ++ VSW PP NG+I YQ+W LGN S N
Sbjct: 341 RLPEKVPSAPPQEVTLK---PGNGTVFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANW 397
Query: 822 SAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPV---LVQLPSPPDLEPGLEVGA 878
+ G + +PG Y VAA T AG G PS PV L Q EP E G
Sbjct: 398 TVVGEQTQLEIATHMPG-SYCVQVAAVTGAGAGEPSRPVCLLLEQAMERATQEPS-EHGP 455
Query: 879 GLAVRLARVLREPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTASFAYTPAV--- 935
+L L+ P +A G A LLLG ++ RR+ R L + A+
Sbjct: 456 WTLEQLRATLKRPEVIATCGVALWLLLLGTAVCIHRRRRARVHLGPGLYRYTSEDAILKH 515
Query: 936 SFPHSEGLSGASSRPPMGLGPAPYSWLADSWPHPSRSPSAQEPRGSCCPSNPDPDDRYYN 995
HS+ WLAD+W S S S S S D R
Sbjct: 516 RMDHSDS-----------------QWLADTW--RSTSGSRDLSSSSSLSSRLGADARDPL 556
Query: 996 EAGISLYLAQTARGTAAPGEGPVYSTIDPAGEELQTFHGGFPQHPSGDLGPWSQYAPPEW 1055
+ SL L+ +R +PG + T G + P PS + P + PP+
Sbjct: 557 DCRRSL-LSWDSR---SPGVPLLPDTSTFYGSLIAELPSSTPARPSPQV-PAVRRLPPQL 611
Query: 1056 SQGDSGAKGGKVKLLGKPVQMPSLNWPEALPPPPPSCELSCLEGPEEELEGSSEPEEWCP 1115
+Q S + + P L+ A + L GS E
Sbjct: 612 AQLSSPCSSSDSLCSRRGLSSPRLSLAPAEAWKAKKKQELQHANSSPLLRGSHSLELRAC 671
Query: 1116 PMPERSHLTEPSSSGGCLVTPSRRETPSPTPSYGQQSTATLTPSPPDPPQPPTDMPHLHQ 1175
+ R S G V + + P S +T P P P + P
Sbjct: 672 ELGNRGSKNLSQSPGA--VPQALVAWRALGPKLLSSSNELVTRHLPPAPLFPHETPPTQS 729
Query: 1176 MPRRVPLGPSSPLSVSQPMLGIREARPAGLGAGPAASPHLSPSPAPS-TASSAPGRTWQG 1234
+ P+ P +P S+ P I P P AS PSPA S +SS+ +
Sbjct: 730 QQTQPPVAPQAPSSILLPAAPIPILSPCS-PPSPQASSLSGPSPASSRLSSSSLSSLGED 788
Query: 1235 NGEMTPPLQGPRARFRKKPKALPYRRENSPGDLPPPPLPPPEEEASWALELRAAGSMSSL 1294
+ P + + + P NS +P P PP + + A + +
Sbjct: 789 QDSVLTPEEVALCLELSEGEETP---RNSVSPMPRAPSPP---TTYGYISVPTASEFTDM 842
Query: 1295 ERERSGERKAVQAVPLAAQRVLHPDEEAWLPYSRPSFLSRGQGTSTCSTAGSNSSRGSSS 1354
R G V +L P P L+ G G+++ A S + SS
Sbjct: 843 GRTGGG-------VGPKGGVLLCPPRPCLTPTPSEGSLANGWGSASEDNAASARASLVSS 895
Query: 1355 SRGS 1358
S GS
Sbjct: 896 SDGS 899
Score = 94.0 bits (232), Expect = 9e-19
Identities = 124/472 (26%), Positives = 183/472 (38%), Gaps = 80/472 (16%)
Query: 258 PSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL---PTGRYEIRSDHSLWI- 313
P L P +Q+ P C+ G PPP +RW L P + + D +L +
Sbjct: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
Query: 314 ----------GHVSAEDEGTYTCVAENSVGRAEASGS-LSVHVPPQ-LVTQPQDQMAAPG 361
G + D G YTC A N +G A + G+ LSV V + QP+D +A G
Sbjct: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVG 151
Query: 362 ESVAFQCETK-GNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAG 420
E +C G+P P + W K+G + L P GR +VS G L + ++ D G
Sbjct: 152 EQFTLECGPPWGHPEPTVSWWKDGKPLALQP-------GRHTVSG-GSLLMARAEKSDEG 203
Query: 421 YYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPA----NQTLVLGS---------S 467
Y+C A + AG ++A D PV L N TL+ +
Sbjct: 204 TYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPA 263
Query: 468 VWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTM-ANGTLYIANVQEMDMGFYSCVAKSS 526
VWL +V+G P+ Q F+T A G +E+ G+ S +
Sbjct: 264 VWLSWKVSGPAAPA----------QSYTALFRTQTAPGGQGAPWAEELLAGWQS----AE 309
Query: 527 TGEATWSG--WLKMREDWGVSPDPPTE------PSSPPGAPSQPVVTEITKNSITLTWKP 578
G W K+R G + P + P P AP Q V + ++ ++W P
Sbjct: 310 LGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVP 369
Query: 579 NPQ-------TGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRA 631
P G V S + PA W V + QLE ++ P + Y V A
Sbjct: 370 PPAENHNGIIRGYQVWSLGNTSLPPA---NWTVVGEQTQLE---IATHMPGS-YCVQVAA 422
Query: 632 VGAWGLSEPSPVSEPV-RTQDSSPSRPVEDP-WRGQQGLAEVAVRLQEPIVL 681
V G EP S PV + + R ++P G L ++ L+ P V+
Sbjct: 423 VTGAGAGEP---SRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRPEVI 471
Score = 79.0 bits (193), Expect = 3e-14
Identities = 56/196 (28%), Positives = 87/196 (44%), Gaps = 11/196 (5%)
Query: 339 GSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFP--SQSLQ 396
G ++ PPQ++ PQDQ+ C+ G PPP I W G + + P L
Sbjct: 24 GGMAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLL 83
Query: 397 PTGRFSV---SPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVI 453
P G + RG + D G Y C+A + G+ +++ S+ L
Sbjct: 84 PDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRG----ARLSVAVLREDF 139
Query: 454 LQGPANQTLVLGSSVWLPCRVT-GNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQ 512
P + V+G L C G+P+P+V W KDG+ L + T++ G+L +A +
Sbjct: 140 QIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR-HTVSGGSLLMARAE 198
Query: 513 EMDMGFYSCVAKSSTG 528
+ D G Y CVA +S G
Sbjct: 199 KSDEGTYMCVATNSAG 214
>gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]
Length = 613
Score = 179 bits (455), Expect = 1e-44
Identities = 145/493 (29%), Positives = 223/493 (45%), Gaps = 40/493 (8%)
Query: 63 MPRIVEQPP--------DLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAH 114
+P + QPP D +V + + C A+G P P+ W +N +R + +DPR
Sbjct: 27 IPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRN-SRFFNIAKDPRVS 85
Query: 115 RLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGN 174
+ SG L G R EG Y C ARN G A S L+V+ +++
Sbjct: 86 -MRRRSGTLVID-FRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP 143
Query: 175 VVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITI-RGGKLMMSHTLKSDAGM 233
VVV G P L+C PP G P P + W ++ R++ G L S+ + D
Sbjct: 144 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQT 203
Query: 234 -YVCVA----SNMAGERESAAAEVM----VLER-PSFLR---RPVNQVVLADAPVTFLCE 280
Y C A ++ ++ +V+ V ER PSF+ +Q+VL + C
Sbjct: 204 DYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECI 263
Query: 281 VKGDPPPRLRWRKEDGELPTGRYEIRS-DHSLWIGHVSAEDEGTYTCVAENSVGRAEASG 339
G P P + W K+ G+LP+ + + + + +L I +VS ED G Y C+A N +G +
Sbjct: 264 ASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTI 323
Query: 340 SLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTG 399
S+ V P + +P++ + APGE C GNP P + W G P QS P
Sbjct: 324 SVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGE-----PLQSAPPNP 378
Query: 400 RFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPAN 459
V+ + Q Y C + G +LA A + + LD +PP +L P N
Sbjct: 379 NREVAG-DTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSV----LD-VPPRMLS-PRN 431
Query: 460 QTL--VLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMG 517
Q + +L + L C G+P P++RW K+GQ D + NG+L I +++ D G
Sbjct: 432 QLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQG 491
Query: 518 FYSCVAKSSTGEA 530
Y+CVA + G+A
Sbjct: 492 IYTCVATNILGKA 504
Score = 134 bits (337), Expect = 6e-31
Identities = 116/383 (30%), Positives = 160/383 (41%), Gaps = 41/383 (10%)
Query: 74 LVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRR 133
+V RG L C A G P P+I WYK G LPS F R
Sbjct: 251 MVLRGMDLLLECIASGVPTPDIAWYKKGGD--------------LPSDKAKFENFNKALR 296
Query: 134 ----ARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDF-RQSPGNVVVAVGEPAVLECV 188
+ D G Y C+A N +G S ++ V V + P N+++A GE L C
Sbjct: 297 ITNVSEEDSGEYFCLASNKMG---SIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVC- 352
Query: 189 PPRGHPEPSVSWRKDGARLKEEEGRIT--IRGGKLMMSHTLKSDAGMYVCVASNMAGERE 246
G+P+P+V W +G L+ + G ++ T S +Y C SN G
Sbjct: 353 RANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL- 411
Query: 247 SAAAEVMVLERPSFLRRPVNQV--VLADAPVTFLCEVKGDPPPRLRWRK--EDGELPTGR 302
A A V VL+ P + P NQ+ V+ C G P P LRW K + L G
Sbjct: 412 LANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGN 471
Query: 303 YEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGE 362
Y + + SL I + ED+G YTCVA N +G+AE L V P ++ P+DQ+A G
Sbjct: 472 YHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGT 531
Query: 363 SVAFQCETKGNP--PPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAG 420
+V +C K +P + W K+ + + G L I V D G
Sbjct: 532 TVQLECRVKHDPSLKLTVSWLKDDEPLYI---------GNRMKKEDDSLTIFGVAERDQG 582
Query: 421 YYVCQAVSVAGSILAKALLEIKG 443
Y C A + LAKA L + G
Sbjct: 583 SYTCVASTELDQDLAKAYLTVLG 605
Score = 128 bits (321), Expect = 4e-29
Identities = 126/495 (25%), Positives = 207/495 (41%), Gaps = 48/495 (9%)
Query: 73 LLVSRGEPATLPCRAE-GRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHG 131
++V G P TL C G P P I W + T +D R + +G L+F ++
Sbjct: 144 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPIT--QDKRVSQG--HNGDLYFSNVM-- 197
Query: 132 RRARPDEGVYTCVAR-NYLGAAASRNA-SLEVAVLRDDFRQSPG---------NVVVAVG 180
+ + Y+C AR ++ +N +L+V R ++P + +V G
Sbjct: 198 --LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRG 255
Query: 181 EPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASN 240
+LEC+ G P P ++W K G L ++ + L +++ + D+G Y C+ASN
Sbjct: 256 MDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASN 314
Query: 241 MAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL-- 298
G + V V P +L P N ++ +C G+P P ++W L
Sbjct: 315 KMGSIRHTIS-VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQS 373
Query: 299 --PTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV-HVPPQLVTQPQD 355
P E+ D ++ Y C N G A+ +SV VPP++++ P++
Sbjct: 374 APPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLS-PRN 431
Query: 356 QMAAP--GESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITA 413
Q+ C G+P P + W K G L G + V G L I
Sbjct: 432 QLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL-------DGGNYHVYENGSLEIKM 484
Query: 414 VQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCR 473
+++ D G Y C A ++ G + LE+K P I + P +Q G++V L CR
Sbjct: 485 IRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRIYRMPEDQVARRGTTVQLECR 538
Query: 474 VTGNP--QPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEAT 531
V +P + +V W KD + L + K + +L I V E D G Y+CVA + +
Sbjct: 539 VKHDPSLKLTVSWLKDDEPLYIGNRMKKE--DDSLTIFGVAERDQGSYTCVASTELDQDL 596
Query: 532 WSGWLKMREDWGVSP 546
+L + + SP
Sbjct: 597 AKAYLTVLGNCPCSP 611
Score = 107 bits (268), Expect = 6e-23
Identities = 88/288 (30%), Positives = 132/288 (45%), Gaps = 19/288 (6%)
Query: 62 AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSG 121
A P +++P +L+++ GE L CRA G P+P ++W NG + + P +R +
Sbjct: 329 AAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSA--PPNPNREVAGDT 386
Query: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQ-SPGNVVVAV- 179
+F + R VY C N G A+ V+VL R SP N ++ V
Sbjct: 387 IIFRDTQISSR------AVYQCNTSNEHGYLL---ANAFVSVLDVPPRMLSPRNQLIRVI 437
Query: 180 -GEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITI-RGGKLMMSHTLKSDAGMYVCV 237
L+C P G P P++ W K+G + G + G L + K D G+Y CV
Sbjct: 438 LYNRTRLDC-PFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCV 496
Query: 238 ASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRL--RWRKED 295
A+N+ G+ E+ + V + R P +QV V C VK DP +L W K+D
Sbjct: 497 ATNILGKAEN-QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDD 555
Query: 296 GELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV 343
L G + D SL I V+ D+G+YTCVA + + A L+V
Sbjct: 556 EPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 603
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 178 bits (452), Expect = 3e-44
Identities = 207/815 (25%), Positives = 327/815 (40%), Gaps = 87/815 (10%)
Query: 75 VSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRA 134
V GE LPC P + Y +++ +++D R + +G L+F ++
Sbjct: 143 VEEGESVVLPCNPPPSAEP-LRIYWMNSKILHIKQDERV--TMGQNGNLYFANVLTSDNH 199
Query: 135 RPD------EGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAV-GEPAVLEC 187
G T + + + S+ R F + + +VA+ G+P VLEC
Sbjct: 200 SDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLEC 259
Query: 188 VPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERES 247
+ G P P++ W + + + L + + D G Y C+A N G
Sbjct: 260 IA-EGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARH 318
Query: 248 AAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKED---GELPTG-RY 303
A V V P +L +P + + C+V+G P P + WR EL +Y
Sbjct: 319 AYY-VTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKY 377
Query: 304 EIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV-HVPPQLVTQP-QDQMAAPG 361
I+ +L + +V D C A N G A+ + V +P +++T Q MA G
Sbjct: 378 RIQRG-ALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQG 436
Query: 362 ESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGY 421
+ C+ G P P++ W E +L RF G L I +Q D G
Sbjct: 437 STAYLLCKAFGAPVPSVQWLDEDGTTVLQDE-------RFFPYANGTLGIRDLQANDTGR 489
Query: 422 YVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNP--Q 479
Y C A + ++ A L++K A+ I QGP + GS V C+ + +P Q
Sbjct: 490 YFCLAANDQNNVTIMANLKVKDATQ------ITQGPRSTIEKKGSRVTFTCQASFDPSLQ 543
Query: 480 PSVRWKKDGQWLQ--GDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLK 537
PS+ W+ DG+ LQ GD ++ + +G L I ++ D G YSCVA + L
Sbjct: 544 PSITWRGDGRDLQELGDSDKY-FIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLL 602
Query: 538 MREDWGVSPDPPTEPSSPPGAPSQPVVTEI---TKNSITLTWKPNPQTGAAVTSYVIE-A 593
+ PG + V++++ T++ + ++W P A + Y IE
Sbjct: 603 V--------------VGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFE 648
Query: 594 FSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSS 653
A W ++ +T T L P Y F V A+ +G EPSPVSE V T +++
Sbjct: 649 DKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAA 708
Query: 654 PSR-PVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAGPE 712
P + PV+ G + V I P + W +D VQ +RV WR G
Sbjct: 709 PEKNPVDVKGEGNETTNMV-------ITWKP----LRW-MDWNAPQVQ-YRVQWRPQGTR 755
Query: 713 GGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPP 772
G W Q S V+ +IKVQA +G G E E+ P P
Sbjct: 756 -GPW---QEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIP 811
Query: 773 --QGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQI--WCLGNE---SRFHLNRS--- 822
+G+ + +S++ V W P +Q G + Y + W G++ S+ H+++
Sbjct: 812 ELEGIEIL----NSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVV 867
Query: 823 AAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPS 857
S +L GL P Y V A G G S
Sbjct: 868 VPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS 902
Score = 176 bits (446), Expect = 1e-43
Identities = 146/518 (28%), Positives = 228/518 (44%), Gaps = 49/518 (9%)
Query: 59 PEDAM--PRIVEQPPD-LLVSRGEPATLPCRAEGRPRPNIEWYKNGARV-------ATVR 108
PE+ M P I EQ P L+V + +L C A G+P W ++G TV
Sbjct: 23 PEELMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVY 82
Query: 109 EDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDF 168
+ P + + F A+ +G+Y C A N LG A S L
Sbjct: 83 QSPHSGSFTITGNNSNF--------AQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWP 134
Query: 169 RQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITI-RGGKLMMSHTL 227
+++ V V GE VL C PP + W +++ R+T+ + G L ++ L
Sbjct: 135 KETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVL 194
Query: 228 KSDAGM-YVCVASNMAGERESAAAEVM---------VLERPSFLRRPVNQ----VVLADA 273
SD Y+C A + G R E + +++R L P N V L
Sbjct: 195 TSDNHSDYICHA-HFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQ 253
Query: 274 PVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDH-SLWIGHVSAEDEGTYTCVAENSV 332
P+ C +G P P ++W + G +P R ++ + +L + V ED+G Y C+AENS+
Sbjct: 254 PLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSL 313
Query: 333 GRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPS 392
G A + ++V P + +PQ + PGE+ C+ +G P P + W+ G P
Sbjct: 314 GSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING-----IPV 368
Query: 393 QSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPV 452
+ L ++ + RG L ++ VQ D C+A + G +LA A + + LP
Sbjct: 369 EELAKDQKYRIQ-RGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVV-----QLPAK 422
Query: 453 ILQGPANQT--LVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIAN 510
IL NQT V GS+ +L C+ G P PSV+W + D +F ANGTL I +
Sbjct: 423 ILTAD-NQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRD 481
Query: 511 VQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDP 548
+Q D G Y C+A + T LK+++ ++ P
Sbjct: 482 LQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGP 519
Score = 148 bits (373), Expect = 4e-35
Identities = 207/831 (24%), Positives = 331/831 (39%), Gaps = 102/831 (12%)
Query: 61 DAMPRIV---EQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLL 117
D PR++ L+ +G+P L C AEG P P I+W + + R + H
Sbjct: 232 DRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKT 291
Query: 118 LPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVV 177
L + D+G Y C+A N LG+A R+A + P + +
Sbjct: 292 LQLLKV----------GEEDDGEYRCLAENSLGSA--RHAYYVTVEAAPYWLHKPQSHLY 339
Query: 178 AVGEPAVLECVPPRGHPEPSVSWRKDGARLKE--EEGRITIRGGKLMMSHTLKSDAGMYV 235
GE A L+C +G P+P V+WR +G ++E ++ + I+ G L++S+ SD +
Sbjct: 340 GPGETARLDC-QVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQ 398
Query: 236 CVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVT--FLCEVKGDPPPRLRWRK 293
C A N G A A + V++ P+ + NQ +A T LC+ G P P ++W
Sbjct: 399 CEARNRHGLL-LANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLD 457
Query: 294 EDGE--LPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVT 351
EDG L R+ ++ +L I + A D G Y C+A N +L V Q+
Sbjct: 458 EDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQ 517
Query: 352 QPQDQMAAPGESVAFQCETKGNPP--PAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQL 409
P+ + G V F C+ +P P+I W+ +G + Q L + ++ + G+L
Sbjct: 518 GPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDL-----QELGDSDKYFIED-GRL 571
Query: 410 NITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVW 469
I ++ D G Y C A + + ++A L + G S +P ++L T W
Sbjct: 572 VIHSLDYSDQGNYSCVASTELDVVESRAQLLVVG-SPGPVPRLVLSDLHLLTQSQVRVSW 630
Query: 470 LPCRVTGNPQPSVRWKKDGQWLQGDDLQF--KTMANGTLYIANVQEMDMGFYSCVAKSST 527
P P ++ D++F K MA Y ++ ++ S K S
Sbjct: 631 SPAEDHNAP------------IEKYDIEFEDKEMAPEKWY--SLGKVPGNQTSTTLKLSP 676
Query: 528 GEATWSGWLKMREDWGVSPDPPTEPS-SPPGAPSQ-PVVTEITKNSIT---LTWKPNP-- 580
+ + P P +E +P AP + PV + N T +TWKP
Sbjct: 677 YVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWM 736
Query: 581 QTGAAVTSYVIEAFSPAAGNTWRT--VADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLS 638
A Y ++ W+ V+D + ++T + + Y V+AV + G
Sbjct: 737 DWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVP----YEIKVQAVNSQGKG 792
Query: 639 EPSPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQL 698
V+ +D + P L+ +L + V W PV L
Sbjct: 793 PEPQVTIGYSGEDYPQAIP----------------ELEGIEILNSSAVLVKWR---PVDL 833
Query: 699 VQ------GFRVS-WRVAGPEGGSWTMLD----LQSPSQQSTVLRGLPPGTQIQIKVQAQ 747
Q G+ V+ WR S + + + S +L GL P + ++VQA
Sbjct: 834 AQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAF 893
Query: 748 GQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQ 807
G G S T S PE P P A+ L N+S+ + W+PPL NGV+T Y
Sbjct: 894 NGRGSGPAS-EFTFSTPEGVPGHPE---ALHLECQSNTSLLLRWQPPL--SHNGVLTGYV 947
Query: 808 I----WCLGNESRFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVG 854
+ G + + N R+ L L P L YR + A T G G
Sbjct: 948 LSYHPLDEGGKGQLSFNLRDPE-LRTHNLTDLSPHLRYRFQLQATTKEGPG 997
Score = 33.5 bits (75), Expect = 1.5
Identities = 23/92 (25%), Positives = 38/92 (41%), Gaps = 5/92 (5%)
Query: 553 SSPPGAPSQPVVTEI---TKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVAD-- 607
S+P G P P + + S+ L W+P +T YV+ G + +
Sbjct: 907 STPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLR 966
Query: 608 GVQLETHTVSGLQPNTIYLFLVRAVGAWGLSE 639
+L TH ++ L P+ Y F ++A G E
Sbjct: 967 DPELRTHNLTDLSPHLRYRFQLQATTKEGPGE 998
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.132 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,638,212
Number of Sequences: 37866
Number of extensions: 4511924
Number of successful extensions: 44052
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 441
Number of HSP's successfully gapped in prelim test: 1725
Number of HSP's that attempted gapping in prelim test: 20013
Number of HSP's gapped (non-prelim): 14054
length of query: 1386
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1271
effective length of database: 13,892,928
effective search space: 17657911488
effective search space used: 17657911488
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.