Search of human proteins with 48475062

Search of human proteins with 48475062

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|48475062 growth differentiation factor 6 precursor [Homo
sapiens]
         (455 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|48475062 growth differentiation factor 6 precursor [Homo sapi...   945   0.0  
gi|4503969 growth differentiation factor 5 preproprotein [Homo s...   341   9e-94
gi|61835232 growth differentiation factor 7 preproprotein [Homo ...   313   2e-85
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa...   143   4e-34
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa...   143   4e-34
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa...   143   4e-34
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap...   142   5e-34
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap...   142   6e-34
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi...   139   7e-33
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]      138   9e-33
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa...   137   2e-32
gi|145611428 bone morphogenetic protein 8A [Homo sapiens]             137   2e-32
gi|7705308 growth differentiation factor 2 [Homo sapiens]             133   3e-31
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi...   132   6e-31
gi|222352098 nodal precursor [Homo sapiens]                           123   3e-28
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa...   115   1e-25
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]     113   3e-25
gi|10190670 growth differentiation factor 3 precursor [Homo sapi...   112   7e-25
gi|4826740 growth differentiation factor 10 precursor [Homo sapi...   110   3e-24
gi|110349792 growth differentiation factor 1 [Homo sapiens]           109   6e-24
gi|4504699 inhibin beta A precursor [Homo sapiens]                    103   4e-22
gi|13899338 activin beta E [Homo sapiens]                              93   4e-19
gi|4885259 myostatin [Homo sapiens]                                    85   1e-16
gi|5031613 growth differentiation factor 11 precursor [Homo sapi...    84   2e-16
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]       84   3e-16
gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]    83   5e-16
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]           79   7e-15
gi|4507465 transforming growth factor, beta 3 [Homo sapiens]           74   2e-13
gi|153792495 growth differentiation factor 15 [Homo sapiens]           74   4e-13
gi|239757187 PREDICTED: similar to growth differentiation factor...    74   4e-13

>gi|48475062 growth differentiation factor 6 precursor [Homo
           sapiens]
          Length = 455

 Score =  945 bits (2442), Expect = 0.0
 Identities = 455/455 (100%), Positives = 455/455 (100%)

Query: 1   MDTPRVLLSAVFLISFLWDLPGFQQASISSSSSSAELGSTKGMRSRKEGKMQRAPRDSDA 60
           MDTPRVLLSAVFLISFLWDLPGFQQASISSSSSSAELGSTKGMRSRKEGKMQRAPRDSDA
Sbjct: 1   MDTPRVLLSAVFLISFLWDLPGFQQASISSSSSSAELGSTKGMRSRKEGKMQRAPRDSDA 60

Query: 61  GREGQEPQPRPQDEPRAQQPRAQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQS 120
           GREGQEPQPRPQDEPRAQQPRAQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQS
Sbjct: 61  GREGQEPQPRPQDEPRAQQPRAQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQS 120

Query: 121 SKSANTITSFVDRGLDDLSHTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAPSAPWGPP 180
           SKSANTITSFVDRGLDDLSHTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAPSAPWGPP
Sbjct: 121 SKSANTITSFVDRGLDDLSHTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAPSAPWGPP 180

Query: 181 AGPLHVQLFPCLSPLLLDARTLDPQGAPPAGWEVFDVWQGLRHQPWKQLCLELRAAWGEL 240
           AGPLHVQLFPCLSPLLLDARTLDPQGAPPAGWEVFDVWQGLRHQPWKQLCLELRAAWGEL
Sbjct: 181 AGPLHVQLFPCLSPLLLDARTLDPQGAPPAGWEVFDVWQGLRHQPWKQLCLELRAAWGEL 240

Query: 241 DAGEAEARARGPQQPPPPDLRSLGFGRRVRPPQERALLVVFTRSQRKNLFAEMREQLGSA 300
           DAGEAEARARGPQQPPPPDLRSLGFGRRVRPPQERALLVVFTRSQRKNLFAEMREQLGSA
Sbjct: 241 DAGEAEARARGPQQPPPPDLRSLGFGRRVRPPQERALLVVFTRSQRKNLFAEMREQLGSA 300

Query: 301 EAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLH 360
           EAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLH
Sbjct: 301 EAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLH 360

Query: 361 VNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCC 420
           VNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCC
Sbjct: 361 VNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCC 420

Query: 421 VPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR 455
           VPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR
Sbjct: 421 VPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR 455


>gi|4503969 growth differentiation factor 5 preproprotein [Homo
           sapiens]
          Length = 501

 Score =  341 bits (874), Expect = 9e-94
 Identities = 195/386 (50%), Positives = 250/386 (64%), Gaps = 49/386 (12%)

Query: 80  PRAQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQSSKSANTITSFVDRGLDDLS 139
           PR  + P R P + PHEYMLS+YRT S A++ G N+S    +  ANTITSF+D+G DD  
Sbjct: 155 PREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRG 214

Query: 140 HTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAPS------APWGPPAGPLHVQLFPC-- 191
              +R+Q+Y+FD+S L +K+ L+GAELR+ R+ PS      AP G  A  L +   P   
Sbjct: 215 PV-VRKQRYVFDISAL-EKDGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGR 272

Query: 192 LSPLLLDARTLDPQGAPPAGWEVFDVWQGLRH-QPWKQLCLELRAAWGELDAGEAEARAR 250
               LLD R++   G   +GWEVFD+W+  R+ +   QLCLEL  AW   + G A     
Sbjct: 273 QPASLLDVRSV--PGLDGSGWEVFDIWKLFRNFKNSAQLCLELE-AW---ERGRA----- 321

Query: 251 GPQQPPPPDLRSLGFGRRVRPPQERALLVVFTRSQRKNL-FAEMREQLGSAEAAGPGAGA 309
                   DLR LGF R  R   E+AL +VF R+++++L F E++ + G  +        
Sbjct: 322 -------VDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKT------ 368

Query: 310 EGSWPPPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWD 369
                          +L S  RR+RR   A+R GKR  K  + RCS+K LHVNFK++GWD
Sbjct: 369 ------------VYEYLFSQ-RRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWD 415

Query: 370 DWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPIS 429
           DWIIAPLEYEA+HCEG+C+FPLRSHLEPTNHA+IQTLMNSMDP STPP+CCVPT+L+PIS
Sbjct: 416 DWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475

Query: 430 ILYIDAGNNVVYKQYEDMVVESCGCR 455
           IL+ID+ NNVVYKQYEDMVVESCGCR
Sbjct: 476 ILFIDSANNVVYKQYEDMVVESCGCR 501


>gi|61835232 growth differentiation factor 7 preproprotein [Homo
           sapiens]
          Length = 450

 Score =  313 bits (802), Expect = 2e-85
 Identities = 194/405 (47%), Positives = 237/405 (58%), Gaps = 46/405 (11%)

Query: 75  PRAQQPRAQEPPG-RGPRVVPHEYMLSIYRTYSIAEKLGINASFFQSSKSANTITSFVDR 133
           PRA+  R     G R   VVPH +M+S+YR+ +     G  A        A+TIT F D+
Sbjct: 68  PRARAARRAAGSGFRNGSVVPHHFMMSLYRSLAGRAPAGAAAVSASGHGRADTITGFTDQ 127

Query: 134 GLDDLSHTPLRRQKYLFDVSMLSDKEELVGAELRLFRQ-APSAPWGPPAGPLHVQLFPC- 191
              D S      Q +LFDVS L+D +E+VGAELR+ R+ +P +  G    P  + L  C 
Sbjct: 128 ATQDESAAETG-QSFLFDVSSLNDADEVVGAELRVLRRGSPESGPGSWTSPPLLLLSTCP 186

Query: 192 ---LSPLLLDARTLDPQGAPPAGWEVFDVWQGLRH-----QPWKQLCLELRAAWGELDAG 243
               +P LL +R  +P       WE FDV   +R      +P +  CL LRA  G +   
Sbjct: 187 GAARAPRLLYSRAAEPLVGQR--WEAFDVADAMRRHRREPRPPRAFCLLLRAVAGPV--- 241

Query: 244 EAEARARGPQQPPPPDLRSLGFG---RRVRPPQERALLVVFTRSQRK-NLFAEMREQLGS 299
                      P P  LR LGFG         +ERA+LVV +R+QRK +LF E+R     
Sbjct: 242 -----------PSPLALRRLGFGWPGGGGSAAEERAVLVVSSRTQRKESLFREIR----- 285

Query: 300 AEAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRRTAFASRH---------GKRHGKKS 350
           A+A   GA       P  G   A P     GRRRRRTA A            G+ HG++ 
Sbjct: 286 AQARALGAALASEPLPDPGTGTASPRAVIGGRRRRRTALAGTRTAQGSGGGAGRGHGRRG 345

Query: 351 RLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSM 410
           R RCS+KPLHV+FKELGWDDWIIAPL+YEAYHCEG+CDFPLRSHLEPTNHAIIQTL+NSM
Sbjct: 346 RSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSM 405

Query: 411 DPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR 455
            P + P SCCVP +L+PISILYIDA NNVVYKQYEDMVVE+CGCR
Sbjct: 406 APDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGCR 450


>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  143 bits (360), Expect = 4e-34
 Identities = 62/124 (50%), Positives = 88/124 (70%), Gaps = 1/124 (0%)

Query: 332 RRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPL 391
           RRRR   + +H  +  +K    C +  L+V+F ++GW+DWI+AP  Y+A++C G C FPL
Sbjct: 286 RRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPL 345

Query: 392 RSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVES 451
             HL  TNHAI+QTL+NS++  S P +CCVPT+L+ IS+LY+D  + VV K Y++MVVE 
Sbjct: 346 ADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEG 404

Query: 452 CGCR 455
           CGCR
Sbjct: 405 CGCR 408


>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  143 bits (360), Expect = 4e-34
 Identities = 62/124 (50%), Positives = 88/124 (70%), Gaps = 1/124 (0%)

Query: 332 RRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPL 391
           RRRR   + +H  +  +K    C +  L+V+F ++GW+DWI+AP  Y+A++C G C FPL
Sbjct: 286 RRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPL 345

Query: 392 RSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVES 451
             HL  TNHAI+QTL+NS++  S P +CCVPT+L+ IS+LY+D  + VV K Y++MVVE 
Sbjct: 346 ADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEG 404

Query: 452 CGCR 455
           CGCR
Sbjct: 405 CGCR 408


>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  143 bits (360), Expect = 4e-34
 Identities = 62/124 (50%), Positives = 88/124 (70%), Gaps = 1/124 (0%)

Query: 332 RRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPL 391
           RRRR   + +H  +  +K    C +  L+V+F ++GW+DWI+AP  Y+A++C G C FPL
Sbjct: 286 RRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPL 345

Query: 392 RSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVES 451
             HL  TNHAI+QTL+NS++  S P +CCVPT+L+ IS+LY+D  + VV K Y++MVVE 
Sbjct: 346 ADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEG 404

Query: 452 CGCR 455
           CGCR
Sbjct: 405 CGCR 408


>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
           sapiens]
          Length = 424

 Score =  142 bits (359), Expect = 5e-34
 Identities = 125/391 (31%), Positives = 168/391 (42%), Gaps = 58/391 (14%)

Query: 85  PPGRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQSSKSANTITSFVDRGL--DDLSHTP 142
           P     +V P EYML +Y  +         A+   S  SAN I SF +  L    +S   
Sbjct: 72  PTQDSAKVDPPEYMLELYNKF---------ATDRTSMPSANIIRSFKNEDLFSQPVSFNG 122

Query: 143 LRRQKYLFDVSMLSDKEELVGAELRLFRQAPSAPWGPPAGPLHVQLFPCLSP-------- 194
           LR+   LF+VS +   EE++ AELRL+                + +F  L          
Sbjct: 123 LRKYPLLFNVS-IPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGER 181

Query: 195 --LLLDARTLDPQGAPPAGWEVFDVWQGLRHQPWKQLCLELRAAWGELDAGEAEARARGP 252
             L+L +  +    +    WE FDV   +R                E    EAE  + G 
Sbjct: 182 NMLVLVSGEIYGTNSE---WETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGR 238

Query: 253 QQPPPPDLRSLGFGRRVRPPQERALLVVFTRSQ-----RKNLFAEM--REQLGSAEAAGP 305
            +                  +   LL+VF+  Q     RK    EM   EQL   +  G 
Sbjct: 239 LEIDTSAQN-----------KHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGL 287

Query: 306 GAGAEGSWPPPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKE 365
            + + G            P   +  + R    + S    R   K    C + PL+++FKE
Sbjct: 288 DSFSSG------------PGEEALLQMRSNIIYDSTARIRRNAKGNY-CKRTPLYIDFKE 334

Query: 366 LGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKL 425
           +GWD WIIAP  YEAY C GVC++PL  HL PT HAIIQ L++  +      +CCVPTKL
Sbjct: 335 IGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKL 394

Query: 426 TPISILYIDAGNNVVYK-QYEDMVVESCGCR 455
            PISILY+D G  V YK +YE M V  CGCR
Sbjct: 395 EPISILYLDKG-VVTYKFKYEGMAVSECGCR 424


>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
           sapiens]
          Length = 454

 Score =  142 bits (358), Expect = 6e-34
 Identities = 99/352 (28%), Positives = 156/352 (44%), Gaps = 56/352 (15%)

Query: 114 NASFFQSSKSANTITSFVDRGLDDLSHTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAP 173
           + +F   +    +  + V+R   D SH     +++ FD++ +   E +  AE R+++   
Sbjct: 147 DTNFLNDADMVMSFVNLVERD-KDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRS 205

Query: 174 SAPWGPPAGPLHVQLFPCLSP--------LLLDARTLDPQGAPPAGWEVFDVWQGLRH-- 223
           +  +      + + ++  +           LLD R      A   GW VFD+     H  
Sbjct: 206 NNRFENET--IKISIYQIIKEYTNRDADLFLLDTRKAQ---ALDVGWLVFDITVTSNHWV 260

Query: 224 -QPWKQLCLELRAAWGELDAGEAEARARGPQQPPPPDLRSLGFGRRVRPPQERALLVVFT 282
             P   L L+L A  G+   G +             +++S G   R  P  ++  +V F 
Sbjct: 261 INPQNNLGLQLCAETGD---GRSI------------NVKSAGLVGRQGPQSKQPFMVAF- 304

Query: 283 RSQRKNLFAEMREQLGSAEAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRRTAFASRH 342
                  F      L S  AA        +                     + ++  S  
Sbjct: 305 -------FKASEVLLRSVRAANKRKNQNRN----------------KSSSHQDSSRMSSV 341

Query: 343 GKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAI 402
           G  +  + +  C K  L+V+F++LGW DWIIAP  Y A++C+G C FPL +H+  TNHAI
Sbjct: 342 GDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAI 401

Query: 403 IQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454
           +QTL++ M P   P  CC PTKL  IS+LY D  +NV+ K+Y +MVV SCGC
Sbjct: 402 VQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453


>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
           sapiens]
          Length = 396

 Score =  139 bits (349), Expect = 7e-33
 Identities = 60/113 (53%), Positives = 83/113 (73%), Gaps = 3/113 (2%)

Query: 345 RHGKKSRLR--CSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAI 402
           +H ++ RL+  C + PL+V+F ++GW+DWI+AP  Y A++C G C FPL  HL  TNHAI
Sbjct: 285 KHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAI 344

Query: 403 IQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR 455
           +QTL+NS++    P +CCVPT+L+ IS+LY+D    VV K Y+DMVVE CGCR
Sbjct: 345 VQTLVNSVN-SKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR 396



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 39/149 (26%), Positives = 69/149 (46%), Gaps = 18/149 (12%)

Query: 83  QEPPGRGPRVVPHEYMLSIYRTYSIAE-KLGINASFFQSSKSANTITSFV-DRGLDDLSH 140
           Q P      VVP  YML +YR +S        +    +++  ANT+ SF  +  L++L  
Sbjct: 65  QRPTPSRDAVVP-PYMLDLYRRHSGQPGSPAPDHRLERAASRANTVRSFHHEESLEELPE 123

Query: 141 TPLRR-QKYLFDVSMLSDKEELVGAELRLFRQAPSAPWGPPAGPLH-VQLFPCLSPL--- 195
           T  +  +++ F++S +  +E +  AEL++FR+      G  +   H + ++  + P    
Sbjct: 124 TSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATAN 183

Query: 196 -------LLDARTLDPQGAPPAGWEVFDV 217
                  LLD R ++      + WE FDV
Sbjct: 184 SKFPVTRLLDTRLVNQNA---SRWESFDV 209


>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
          Length = 431

 Score =  138 bits (348), Expect = 9e-33
 Identities = 103/344 (29%), Positives = 151/344 (43%), Gaps = 56/344 (16%)

Query: 124 ANTITSFVDRGLDDLS--HTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAPSAPWGPPA 181
           A+ + SFV+    D    H     +++ FD+S + + E +  AE R+++      +    
Sbjct: 130 ADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDYIRERFDNET 189

Query: 182 GPLHVQLFPCLSP--------LLLDARTLDPQGAPPAGWEVFDVWQGLRH---QPWKQLC 230
               + ++  L           LLD+RTL    A   GW VFD+     H    P   L 
Sbjct: 190 --FRISVYQVLQEHLGRESDLFLLDSRTL---WASEEGWLVFDITATSNHWVVNPRHNLG 244

Query: 231 LELRAAWGELDAGEAEARARGPQQPPPPDLRSLGFGRRVRPPQERALLVVFTRSQRKNLF 290
           L+L      LD            Q   P L  L  GR   P  ++  +V F        F
Sbjct: 245 LQLSVE--TLDG-----------QSINPKLAGL-IGRH-GPQNKQPFMVAF--------F 281

Query: 291 AEMREQLGSAEAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKS 350
                   S  + G    ++     P      R                +   +      
Sbjct: 282 KATEVHFRSIRSTGSKQRSQNRSKTPKNQEALR---------------MANVAENSSSDQ 326

Query: 351 RLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSM 410
           R  C K  L+V+F++LGW DWIIAP  Y AY+CEG C FPL S++  TNHAI+QTL++ +
Sbjct: 327 RQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFI 386

Query: 411 DPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454
           +P + P  CC PT+L  IS+LY D  +NV+ K+Y +MVV +CGC
Sbjct: 387 NPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430


>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
           sapiens]
          Length = 402

 Score =  137 bits (346), Expect = 2e-32
 Identities = 121/401 (30%), Positives = 178/401 (44%), Gaps = 75/401 (18%)

Query: 75  PRAQQPRAQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQSSKSANTITSFVDRG 134
           P   +PRA     R P   P  +ML +Y   +  +     A   +    A+ + SFV+  
Sbjct: 55  PGRPRPRAPPAASRLPASAPL-FMLDLYHAMA-GDDDEDGAPAERRLGRADLVMSFVNMV 112

Query: 135 LDD--LSHTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAPSAPWGPPAGPLHVQLFPCL 192
             D  L H     +++ FD++ +   E +  AE R+++  PS         LHV +F  +
Sbjct: 113 ERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYK-VPSIHLLNRT--LHVSMFQVV 169

Query: 193 SP--------LLLDARTLDPQGAPPAGWEVFDV------WQGLRHQPWKQLCLELRAAWG 238
                       LD +TL    A   GW V DV      W   RH   K L L L   + 
Sbjct: 170 QEQSNRESDLFFLDLQTLR---AGDEGWLVLDVTAASDCWLLKRH---KDLGLRL---YV 220

Query: 239 ELDAGEAEARARGPQQPPPPDLRSLGFGRRVRPPQERALLVVFTRSQRKNLFAEMREQLG 298
           E + G +            P L  L  G+R  P  ++  +V F R+              
Sbjct: 221 ETEDGHSV----------DPGLAGL-LGQRA-PRSQQPFVVTFFRAS------------- 255

Query: 299 SAEAAGPGAGAEGSWPPPSGAPDA-RPWLPSPGRRRRRTAFASR----HGKRHGKKSRLR 353
                          P P   P A RP      ++      A+R        HG   R  
Sbjct: 256 ---------------PSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQV 300

Query: 354 CSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPG 413
           C +  L+V+F++LGW DW+IAP  Y AY+CEG C FPL S +  TNHAI+Q+L++ M P 
Sbjct: 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPD 360

Query: 414 STPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454
           + P +CC PTKL+  S+LY D+ NNV+ +++ +MVV++CGC
Sbjct: 361 AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401


>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
          Length = 402

 Score =  137 bits (345), Expect = 2e-32
 Identities = 121/401 (30%), Positives = 177/401 (44%), Gaps = 75/401 (18%)

Query: 75  PRAQQPRAQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQSSKSANTITSFVDRG 134
           P   +PRA     R P   P  +ML +Y   +  +     A   Q    A+ + SFV+  
Sbjct: 55  PGRPRPRAPPAASRLPASAPL-FMLDLYHAMA-GDDDEDGAPAEQRLGRADLVMSFVNMV 112

Query: 135 LDD--LSHTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAPSAPWGPPAGPLHVQLFPCL 192
             D  L H     +++ FD++ +   E +  AE R+++  PS         LHV +F  +
Sbjct: 113 ERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYK-VPSIHLLNRT--LHVSMFQVV 169

Query: 193 SP--------LLLDARTLDPQGAPPAGWEVFDV------WQGLRHQPWKQLCLELRAAWG 238
                       LD +TL    A   GW V DV      W   RH   K L L L   + 
Sbjct: 170 QEQSNRESDLFFLDLQTLR---AGDEGWLVLDVTAASDCWLLKRH---KDLGLRL---YV 220

Query: 239 ELDAGEAEARARGPQQPPPPDLRSLGFGRRVRPPQERALLVVFTRSQRKNLFAEMREQLG 298
           E + G +            P L  L  G+R  P  ++  +V F R+              
Sbjct: 221 ETEDGHSV----------DPGLAGL-LGQRA-PRSQQPFVVTFFRAS------------- 255

Query: 299 SAEAAGPGAGAEGSWPPPSGAPDA-RPWLPSPGRRRRRTAFASR----HGKRHGKKSRLR 353
                          P P   P A RP      ++      A+R         G   R  
Sbjct: 256 ---------------PSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVRGSHGRQV 300

Query: 354 CSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPG 413
           C +  L+V+F++LGW DW+IAP  Y AY+CEG C FPL S +  TNHAI+Q+L++ M P 
Sbjct: 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMKPN 360

Query: 414 STPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454
           + P +CC PTKL+  S+LY D+ NNV+ +++ +MVV++CGC
Sbjct: 361 AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401


>gi|7705308 growth differentiation factor 2 [Homo sapiens]
          Length = 429

 Score =  133 bits (335), Expect = 3e-31
 Identities = 116/384 (30%), Positives = 171/384 (44%), Gaps = 55/384 (14%)

Query: 91  RVVPHEYMLSIYRTYSIAEKLGINASFFQSSKSANTITSFVDRGLDDLSHT---PLRRQK 147
           RV P +YM+ +Y  Y+         S   ++ ++N + SF       ++ T   P ++  
Sbjct: 82  RVEPPQYMIDLYNRYT---------SDKSTTPASNIVRSFSMEDAISITATEDFPFQKHI 132

Query: 148 YLFDVSMLSDKEELVGAELRLFRQAPSAPWGPPAGPLHVQLFPCLSPLLLDARTLDPQGA 207
            LF++S +   E++  AELRL+    +          HV     L   ++    LD   A
Sbjct: 133 LLFNIS-IPRHEQITRAELRLYVSCQN----------HVDPSHDLKGSVVIYDVLDGTDA 181

Query: 208 PPAGWEV--FDVWQGLRHQPWKQLCLELRAA---WGELDAGEAEARARGPQQPPPPDLRS 262
             +  E   F V Q ++ + W+ L  E+ +A   W   D+ +++ +     +       +
Sbjct: 182 WDSATETKTFLVSQDIQDEGWETL--EVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDT 239

Query: 263 LGFGRRVRPPQERAL--LVVFTR---SQRKNLFAEMREQLGSAEAA-----GPGAGAEGS 312
           L       PP  R L   VVF+    S  K    E+RE +   + +           E  
Sbjct: 240 LDISV---PPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAG 296

Query: 313 WPPPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWI 372
                   D      S   RR+R+A A  H           C K  L VNF+++GWD WI
Sbjct: 297 ESSHEEDTDGHVAAGSTLARRKRSAGAGSH-----------CQKTSLRVNFEDIGWDSWI 345

Query: 373 IAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILY 432
           IAP EYEAY C+G C FPL   + PT HAI+QTL++   P     +CCVPTKL+PIS+LY
Sbjct: 346 IAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLY 405

Query: 433 -IDAGNNVVYKQYEDMVVESCGCR 455
             D G   +   YE M V  CGCR
Sbjct: 406 KDDMGVPTLKYHYEGMSVAECGCR 429


>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
           sapiens]
          Length = 513

 Score =  132 bits (332), Expect = 6e-31
 Identities = 55/101 (54%), Positives = 73/101 (72%)

Query: 354 CSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPG 413
           C K  L+V+F++LGW DWIIAP  Y A +C+G C FPL +H+  TNHAI+QTL++ M+P 
Sbjct: 412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPE 471

Query: 414 STPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454
             P  CC PTKL  IS+LY D  +NV+ K+Y +MVV +CGC
Sbjct: 472 YVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512



 Score = 33.1 bits (74), Expect = 0.53
 Identities = 28/119 (23%), Positives = 52/119 (43%), Gaps = 5/119 (4%)

Query: 54  APRDSDAGREGQEPQPRPQDEPRAQQPRAQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGI 113
           A  D D   EG+  Q  P +   + Q R Q PPG    +     +     +   +     
Sbjct: 145 ADNDEDGASEGERQQSWPHEAASSSQ-RRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSA 203

Query: 114 NASFFQSSKSANTITSFVDRGLDDLSHTPLRR--QKYLFDVSMLSDKEELVGAELRLFR 170
             S F +   A+ + SFV+    D   +P +R  +++ F++S + + E +  AE R+++
Sbjct: 204 QDSAFLN--DADMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYK 260


>gi|222352098 nodal precursor [Homo sapiens]
          Length = 347

 Score =  123 bits (309), Expect = 3e-28
 Identities = 99/320 (30%), Positives = 133/320 (41%), Gaps = 61/320 (19%)

Query: 148 YLFDVSMLSDKEELVGAELRLFRQAPSAPWGPPAGPLHVQLF------------PCLSPL 195
           + FD S LS +E+L  AELRL   +P     P  G L +++F             CL   
Sbjct: 75  FAFDFSFLSQQEDLAWAELRLQLSSPVDL--PTEGSLAIEIFHQPKPDTEQASDSCLERF 132

Query: 196 LLDARTLD-PQGAPPAGWEVFDVWQGLRHQPWKQLCLELRAAWGELDAGEAEARARGPQQ 254
            +D  T+   Q     G  V +V + L         LE + +           R  G   
Sbjct: 133 QMDLFTVTLSQVTFSLGSMVLEVTRPLSKWLKHPGALEKQMS-----------RVAGECW 181

Query: 255 PPPPDLRSLGFGRRVRPPQERALLVVFTRSQRKNLFAEMREQLGSAEAAGPGAGAEGSWP 314
           P PP            PP    LL++++     NL  E R QLG +        AE SW 
Sbjct: 182 PRPPT-----------PPATNVLLMLYS-----NLSQEQR-QLGGSTLLWE---AESSWR 221

Query: 315 PPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIA 374
              G      W            +  RH + H       C K    V+F  +GW  WII 
Sbjct: 222 AQEGQLS---W-----------EWGKRHRRHHLPDRSQLCRKVKFQVDFNLIGWGSWIIY 267

Query: 375 PLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYID 434
           P +Y AY CEG C  P+     PTNHA IQ+L+    P   P +CC P K  P+S+LY+D
Sbjct: 268 PKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVD 327

Query: 435 AGNNVVYKQYEDMVVESCGC 454
            G  V+   ++DM+VE CGC
Sbjct: 328 NG-RVLLDHHKDMIVEECGC 346


>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
           sapiens]
          Length = 472

 Score =  115 bits (287), Expect = 1e-25
 Identities = 54/145 (37%), Positives = 87/145 (60%), Gaps = 6/145 (4%)

Query: 316 PSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLR---CSKKPLHVNFKELGWDDWI 372
           P  + + +     P R+ +   F  +  K+  +K  +    C+++ L V+F ++GW +WI
Sbjct: 329 PEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWI 388

Query: 373 IAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMD--PGSTPPSCCVPTKLTPISI 430
           I+P  ++AY+C G C FP+   L+P+NHA IQ+++ ++   PG  P  CCVP K++ +SI
Sbjct: 389 ISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPG-IPEPCCVPEKMSSLSI 447

Query: 431 LYIDAGNNVVYKQYEDMVVESCGCR 455
           L+ D   NVV K Y +M VESC CR
Sbjct: 448 LFFDENKNVVLKVYPNMTVESCACR 472


>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
          Length = 392

 Score =  113 bits (283), Expect = 3e-25
 Identities = 52/120 (43%), Positives = 71/120 (59%)

Query: 336 TAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHL 395
           +A  +    +H      +CS  P  ++F++LGWD WIIAP  Y   +C+G C   LR  L
Sbjct: 273 SAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGL 332

Query: 396 EPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR 455
              NHAIIQ L+N +   S P   CVP K  PIS+L I+A  +++YK+YE M+ ESC CR
Sbjct: 333 NSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR 392


>gi|10190670 growth differentiation factor 3 precursor [Homo
           sapiens]
          Length = 364

 Score =  112 bits (280), Expect = 7e-25
 Identities = 49/101 (48%), Positives = 69/101 (68%), Gaps = 1/101 (0%)

Query: 354 CSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPG 413
           C +  L +NF++LGW  WIIAP  + A +C G C F L   L  +N+A +Q LM+++DP 
Sbjct: 264 CHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDP- 322

Query: 414 STPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454
             P + C+PTKL+PIS+LY D  +NV+ + YEDMVV+ CGC
Sbjct: 323 EIPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGC 363


>gi|4826740 growth differentiation factor 10 precursor [Homo
           sapiens]
          Length = 478

 Score =  110 bits (274), Expect = 3e-24
 Identities = 58/161 (36%), Positives = 93/161 (57%), Gaps = 24/161 (14%)

Query: 313 WPPPSGAPDARPWLPSPGRRRRRTA------FASR---HGKRHGKKSRLR-------CSK 356
           WP P      R   P PGR+ RR         AS+     ++  +K+R +       CS+
Sbjct: 324 WPSPF-----RALKPRPGRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWDEPRVCSR 378

Query: 357 KPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMD--PGS 414
           + L V+F ++GW++WII+P  ++AY+C G C+FP+   + P+NHA IQ+++ ++   PG 
Sbjct: 379 RYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPG- 437

Query: 415 TPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR 455
            P  CCVP K+  + +L++D   NVV K Y +M V++C CR
Sbjct: 438 IPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478


>gi|110349792 growth differentiation factor 1 [Homo sapiens]
          Length = 372

 Score =  109 bits (272), Expect = 6e-24
 Identities = 58/136 (42%), Positives = 81/136 (59%), Gaps = 9/136 (6%)

Query: 324 PWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHC 383
           P L  P  R RR A     G   G      C  + L+V+F+E+GW  W+IAP  + A +C
Sbjct: 242 PRLCHPLARPRRDAEPVLGGGPGGA-----CRARRLYVSFREVGWHRWVIAPRGFLANYC 296

Query: 384 EGVCDFPLR---SHLEPT-NHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNV 439
           +G C  P+    S   P  NHA+++ LM++  PG+    CCVP +L+PIS+L+ D  +NV
Sbjct: 297 QGQCALPVALSGSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNV 356

Query: 440 VYKQYEDMVVESCGCR 455
           V +QYEDMVV+ CGCR
Sbjct: 357 VLRQYEDMVVDECGCR 372


>gi|4504699 inhibin beta A precursor [Homo sapiens]
          Length = 426

 Score =  103 bits (256), Expect = 4e-22
 Identities = 68/183 (37%), Positives = 91/183 (49%), Gaps = 13/183 (7%)

Query: 276 ALLVVFTRSQRKNLFAEMREQLGSAEAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRR 335
           A LV+  + ++K    E +++ G    AG     E S  P      AR     P RRRRR
Sbjct: 252 ASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLML-QARQSEDHPHRRRRR 310

Query: 336 TAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLR--- 392
                  G     K  + C KK   V+FK++GW+DWIIAP  Y A +CEG C   +    
Sbjct: 311 -------GLECDGKVNI-CCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTS 362

Query: 393 -SHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVES 451
            S L   +  I    M    P +   SCCVPTKL P+S+LY D G N++ K  ++M+VE 
Sbjct: 363 GSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEE 422

Query: 452 CGC 454
           CGC
Sbjct: 423 CGC 425


>gi|13899338 activin beta E [Homo sapiens]
          Length = 350

 Score = 93.2 bits (230), Expect = 4e-19
 Identities = 48/130 (36%), Positives = 70/130 (53%), Gaps = 10/130 (7%)

Query: 327 PSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGV 386
           P  GR RRRT           + +   C ++  +V+F+ELGW DWI+ P  Y+  +C G 
Sbjct: 228 PGAGRARRRTPTC--------EPATPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQ 279

Query: 387 CDFPLRSH--LEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQY 444
           C   L     +  + H+ + +L+ + +P     SCCVPT   P+S+LY+D   NVV    
Sbjct: 280 CPPHLAGSPGIAASFHSAVFSLLKANNPWPASTSCCVPTARRPLSLLYLDHNGNVVKTDV 339

Query: 445 EDMVVESCGC 454
            DMVVE+CGC
Sbjct: 340 PDMVVEACGC 349


>gi|4885259 myostatin [Homo sapiens]
          Length = 375

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 39/102 (38%), Positives = 59/102 (57%), Gaps = 7/102 (6%)

Query: 353 RCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDP 412
           RC + PL V+F+  GWD WIIAP  Y+A +C G C+F        T+      L++  +P
Sbjct: 280 RCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLQKYPHTH------LVHQANP 332

Query: 413 GSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454
             +   CC PTK++PI++LY +    ++Y +   MVV+ CGC
Sbjct: 333 RGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 374


>gi|5031613 growth differentiation factor 11 precursor [Homo
           sapiens]
          Length = 407

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 39/105 (37%), Positives = 59/105 (56%), Gaps = 7/105 (6%)

Query: 350 SRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNS 409
           S  RC + PL V+F+  GWD WIIAP  Y+A +C G C++        T+      L+  
Sbjct: 309 SESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEYMFMQKYPHTH------LVQQ 361

Query: 410 MDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454
            +P  +   CC PTK++PI++LY +    ++Y +   MVV+ CGC
Sbjct: 362 ANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406


>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
          Length = 407

 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 41/105 (39%), Positives = 62/105 (59%), Gaps = 5/105 (4%)

Query: 354 CSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRS---HLEPTNHAII-QTLMNS 409
           C ++   ++F+ +GW+DWIIAP  Y   +CEG C   L          + A++ Q  M  
Sbjct: 303 CCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRG 362

Query: 410 MDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454
           ++PG T  SCC+PTKL+ +S+LY D   N+V +   +M+VE CGC
Sbjct: 363 LNPG-TVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGC 406


>gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]
          Length = 454

 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 34/102 (33%), Positives = 54/102 (52%)

Query: 354 CSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPG 413
           C      ++F +L WD+WI+AP  Y   +C+G C   +        H ++Q ++      
Sbjct: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDS 412

Query: 414 STPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR 455
           S P   CVP K +P+S+L I+   ++ YK+YEDM+   C CR
Sbjct: 413 SVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454


>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
          Length = 352

 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 39/105 (37%), Positives = 55/105 (52%), Gaps = 4/105 (3%)

Query: 354 CSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSH--LEPTNHAIIQTLMNSMD 411
           C ++   V+F+E+GW DWII P  Y    C G C   +     +  + H  +  L+ +  
Sbjct: 247 CCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKANT 306

Query: 412 PGSTPP--SCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454
              T    SCCVPT   P+S+LY D  +N+V     DMVVE+CGC
Sbjct: 307 AAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGC 351


>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
          Length = 412

 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 44/129 (34%), Positives = 73/129 (56%), Gaps = 9/129 (6%)

Query: 327 PSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKE-LGWDDWIIAPLEYEAYHCEG 385
           P  G +R++ A  + +  R+ +++   C  +PL+++F++ LGW  W+  P  Y A  C G
Sbjct: 291 PGQGGQRKKRALDTNYCFRNLEEN---CCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSG 346

Query: 386 VCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYE 445
            C + LRS    T H+ +  L N+++P ++   CCVP  L P++ILY   G     +Q  
Sbjct: 347 PCPY-LRS--ADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYY-VGRTPKVEQLS 402

Query: 446 DMVVESCGC 454
           +MVV+SC C
Sbjct: 403 NMVVKSCKC 411


>gi|153792495 growth differentiation factor 15 [Homo sapiens]
          Length = 308

 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 52/185 (28%), Positives = 80/185 (43%), Gaps = 19/185 (10%)

Query: 282 TRSQRKNLFAEMREQLGSAEAAGPGAGAEGSWPPPSGAPD-------ARPWL-----PSP 329
           T S+  ++   +R QL  A    P      S PPPS +         ARP L     P  
Sbjct: 130 TASRSWDVTRPLRRQLSLARPQAPALHLRLS-PPPSQSDQLLAESSSARPQLELHLRPQA 188

Query: 330 GRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDF 389
            R RRR    +R+G          C    +  + ++LGW DW+++P E +   C G C  
Sbjct: 189 ARGRRRAR--ARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPS 246

Query: 390 PLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVV 449
             R+      HA I+T ++ + P + P  CCVP    P+ +L       V  + Y+D++ 
Sbjct: 247 QFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLA 302

Query: 450 ESCGC 454
           + C C
Sbjct: 303 KDCHC 307


>gi|239757187 PREDICTED: similar to growth differentiation factor 15
           [Homo sapiens]
          Length = 270

 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 52/185 (28%), Positives = 80/185 (43%), Gaps = 19/185 (10%)

Query: 282 TRSQRKNLFAEMREQLGSAEAAGPGAGAEGSWPPPSGAPD-------ARPWL-----PSP 329
           T S+  ++   +R QL  A    P      S PPPS +         ARP L     P  
Sbjct: 92  TASRSWDVTRPLRRQLSLARPQAPALHLRLS-PPPSQSDQLLAESSSARPQLELHLRPQA 150

Query: 330 GRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDF 389
            R RRR    +R+G          C    +  + ++LGW DW+++P E +   C G C  
Sbjct: 151 ARGRRRAR--ARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPS 208

Query: 390 PLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVV 449
             R+      HA I+T ++ + P + P  CCVP    P+ +L       V  + Y+D++ 
Sbjct: 209 QFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLA 264

Query: 450 ESCGC 454
           + C C
Sbjct: 265 KDCHC 269


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,081,582
Number of Sequences: 37866
Number of extensions: 1232773
Number of successful extensions: 9434
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 97
Number of HSP's successfully gapped in prelim test: 187
Number of HSP's that attempted gapping in prelim test: 8716
Number of HSP's gapped (non-prelim): 830
length of query: 455
length of database: 18,247,518
effective HSP length: 106
effective length of query: 349
effective length of database: 14,233,722
effective search space: 4967568978
effective search space used: 4967568978
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.