Guide to the Human Genome
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Search of human proteins with 13375952

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13375952 TBC1 domain family, member 17 [Homo sapiens]
         (648 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13375952 TBC1 domain family, member 17 [Homo sapiens]             1335   0.0  
gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]   597   e-170
gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]   596   e-170
gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]   586   e-167
gi|33563376 TBC1 domain family, member 16 [Homo sapiens]              201   2e-51
gi|54607014 TBC1 domain family, member 25 [Homo sapiens]              187   3e-47
gi|23503283 TBC1 domain family, member 21 [Homo sapiens]              120   5e-27
gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sa...   118   2e-26
gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sa...   118   2e-26
gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sap...   118   2e-26
gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sap...   118   2e-26
gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo sa...   115   1e-25
gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo sa...   115   1e-25
gi|40068063 TBC1 domain family, member 22B [Homo sapiens]              77   6e-14
gi|190014603 TBC1 domain family, member 13 [Homo sapiens]              74   3e-13
gi|22507409 TBC1 domain family, member 22A [Homo sapiens]              70   5e-12
gi|34147456 TBC domain-containing protein kinase-like [Homo sapi...    68   3e-11
gi|38348348 TBC1 domain family, member 10C [Homo sapiens]              66   1e-10
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]    65   1e-10
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]    65   1e-10
gi|13994322 TBC1 domain family, member 10A [Homo sapiens]              64   3e-10
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]               61   3e-09
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]             61   3e-09
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]            61   4e-09
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo...    54   3e-07
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member...    54   4e-07
gi|229577000 ecotropic viral integration site 5-like isoform 1 [...    53   8e-07
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H...    53   8e-07
gi|68299759 ecotropic viral integration site 5 [Homo sapiens]          53   8e-07
gi|167614488 TBC1 domain family, member 10B [Homo sapiens]             53   8e-07

>gi|13375952 TBC1 domain family, member 17 [Homo sapiens]
          Length = 648

 Score = 1335 bits (3455), Expect = 0.0
 Identities = 648/648 (100%), Positives = 648/648 (100%)

Query: 1   MEGAGYRVVFEKGGVYLHTSAKKYQDRDSLIAGVIRVVEKDNDVLLHWAPVEEAGDSTQI 60
           MEGAGYRVVFEKGGVYLHTSAKKYQDRDSLIAGVIRVVEKDNDVLLHWAPVEEAGDSTQI
Sbjct: 1   MEGAGYRVVFEKGGVYLHTSAKKYQDRDSLIAGVIRVVEKDNDVLLHWAPVEEAGDSTQI 60

Query: 61  LFSKKDSSGGDSCASEEEPTFDPGYEPDWAVISTVRPQPCHSEPTRGAEPSCPQGSWAFS 120
           LFSKKDSSGGDSCASEEEPTFDPGYEPDWAVISTVRPQPCHSEPTRGAEPSCPQGSWAFS
Sbjct: 61  LFSKKDSSGGDSCASEEEPTFDPGYEPDWAVISTVRPQPCHSEPTRGAEPSCPQGSWAFS 120

Query: 121 VSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSPQD 180
           VSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSPQD
Sbjct: 121 VSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSPQD 180

Query: 181 SRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQP 240
           SRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQP
Sbjct: 181 SRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQP 240

Query: 241 QPEGAASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVP 300
           QPEGAASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVP
Sbjct: 241 QPEGAASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVP 300

Query: 301 ELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPE 360
           ELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPE
Sbjct: 301 ELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPE 360

Query: 361 QERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGM 420
           QERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGM
Sbjct: 361 QERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGM 420

Query: 421 SDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDF 480
           SDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDF
Sbjct: 421 SDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDF 480

Query: 481 LDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDT 540
           LDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDT
Sbjct: 481 LDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDT 540

Query: 541 LMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELPHNVQEILGLAPPAEP 600
           LMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELPHNVQEILGLAPPAEP
Sbjct: 541 LMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELPHNVQEILGLAPPAEP 600

Query: 601 HSPSPTASPLPLSPTRAPPTPPPSTDTAPQPDSSLEILPEEEDEGADS 648
           HSPSPTASPLPLSPTRAPPTPPPSTDTAPQPDSSLEILPEEEDEGADS
Sbjct: 601 HSPSPTASPLPLSPTRAPPTPPPSTDTAPQPDSSLEILPEEEDEGADS 648


>gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]
          Length = 696

 Score =  597 bits (1539), Expect = e-170
 Identities = 310/609 (50%), Positives = 415/609 (68%), Gaps = 26/609 (4%)

Query: 7   RVVFEKGGVYLHTSAKKYQDRDSLIAGVIRVVEKDNDVLLHWAPVEEAGDSTQILFSKKD 66
           ++++E+ GVY+H+S  K  D+D LI+G++RV+EKD +V++ W P+++A DS+ IL+++KD
Sbjct: 32  KIIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWRPLDDALDSSSILYARKD 91

Query: 67  SSGGDSCASEEEPTFDPG------YEPDWAVISTVRPQPCHSEPTRGAEPSCPQGS--WA 118
           SS         +     G      YE +W +++TV  +      T G  PS   G   W+
Sbjct: 92  SSSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFK--RKPHTNGDAPSHRNGKSKWS 149

Query: 119 FSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSP 178
           F  SL +LKSI+++K G+ W+YLV   +    LPALHFH+G ++ L+  L +Y++L  SP
Sbjct: 150 FLFSLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKLLIESLEKYVVLCESP 209

Query: 179 QDSRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGAL 238
           QD R  LV   + S LS SF +L   D+ +  ++ +  +DPY+ T   FS+VTN+   +L
Sbjct: 210 QDKRTLLVNCQNKS-LSQSFENL--LDEPAYGLIQKIKKDPYTATMIGFSKVTNYIFDSL 266

Query: 239 Q---------PQPEGA--ASDLPP--PPDDEPEPGFEVISCVELGPRPTVERGPPVTEEE 285
           +         P  E A   SD  P    + + EPGFEVI+ ++LG RP V+R  PV+ EE
Sbjct: 267 RGSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEE 326

Query: 286 WARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTD 345
           W +++  EGR+  V  +K  IF GGLS +LR++AWKFLLGY  W+ T EE     ++KTD
Sbjct: 327 WTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTD 386

Query: 346 EYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILL 405
           EYFRMKLQWKS+S EQE+RNS L  YRSLIE+DV+RTDRTNKFYEG +NPGL LL+DIL+
Sbjct: 387 EYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILM 446

Query: 406 TYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGR 465
           TYCMY FDLGYVQGMSDLLSP+LYV++NEVDAFWCF  +M+ +  NFEE  + MK QL +
Sbjct: 447 TYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQ 506

Query: 466 LLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNL 525
           L  LLR+LD   C +L+SQDSG L FCFRWLLI FKREF F D+LRLWEV+WT LP  N 
Sbjct: 507 LSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNF 566

Query: 526 HLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELP 585
           HLL+ CAIL+ E+  +M   +G NEILKHINEL+MK+ VED+L +AEA+  Q+  C ELP
Sbjct: 567 HLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELP 626

Query: 586 HNVQEILGL 594
             V EILGL
Sbjct: 627 QAVCEILGL 635


>gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]
          Length = 682

 Score =  596 bits (1537), Expect = e-170
 Identities = 310/608 (50%), Positives = 414/608 (68%), Gaps = 26/608 (4%)

Query: 8   VVFEKGGVYLHTSAKKYQDRDSLIAGVIRVVEKDNDVLLHWAPVEEAGDSTQILFSKKDS 67
           +++E+ GVY+H+S  K  D+D LI+G++RV+EKD +V++ W P+++A DS+ IL+++KDS
Sbjct: 19  IIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWRPLDDALDSSSILYARKDS 78

Query: 68  SGGDSCASEEEPTFDPG------YEPDWAVISTVRPQPCHSEPTRGAEPSCPQGS--WAF 119
           S         +     G      YE +W +++TV  +      T G  PS   G   W+F
Sbjct: 79  SSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFK--RKPHTNGDAPSHRNGKSKWSF 136

Query: 120 SVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSPQ 179
             SL +LKSI+++K G+ W+YLV   +    LPALHFH+G ++ L+  L +Y++L  SPQ
Sbjct: 137 LFSLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKLLIESLEKYVVLCESPQ 196

Query: 180 DSRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQ 239
           D R  LV   + S LS SF +L   D+ +  ++ +  +DPY+ T   FS+VTN+   +L+
Sbjct: 197 DKRTLLVNCQNKS-LSQSFENL--LDEPAYGLIQKIKKDPYTATMIGFSKVTNYIFDSLR 253

Query: 240 ---------PQPEGA--ASDLPP--PPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEW 286
                    P  E A   SD  P    + + EPGFEVI+ ++LG RP V+R  PV+ EEW
Sbjct: 254 GSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEW 313

Query: 287 ARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDE 346
            +++  EGR+  V  +K  IF GGLS +LR++AWKFLLGY  W+ T EE     ++KTDE
Sbjct: 314 TKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDE 373

Query: 347 YFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLT 406
           YFRMKLQWKS+S EQE+RNS L  YRSLIE+DV+RTDRTNKFYEG +NPGL LL+DIL+T
Sbjct: 374 YFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMT 433

Query: 407 YCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRL 466
           YCMY FDLGYVQGMSDLLSP+LYV++NEVDAFWCF  +M+ +  NFEE  + MK QL +L
Sbjct: 434 YCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQL 493

Query: 467 LLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLH 526
             LLR+LD   C +L+SQDSG L FCFRWLLI FKREF F D+LRLWEV+WT LP  N H
Sbjct: 494 STLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFH 553

Query: 527 LLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELPH 586
           LL+ CAIL+ E+  +M   +G NEILKHINEL+MK+ VED+L +AEA+  Q+  C ELP 
Sbjct: 554 LLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQ 613

Query: 587 NVQEILGL 594
            V EILGL
Sbjct: 614 AVCEILGL 621


>gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]
          Length = 713

 Score =  586 bits (1511), Expect = e-167
 Identities = 311/626 (49%), Positives = 415/626 (66%), Gaps = 43/626 (6%)

Query: 7   RVVFEKGGVYLHTSAKKYQDRDSLIAGVIRVVEKDNDVLLHWAPVEEAGDSTQILFSKKD 66
           ++++E+ GVY+H+S  K  D+D LI+G++RV+EKD +V++ W P+++A DS+ IL+++KD
Sbjct: 32  KIIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWRPLDDALDSSSILYARKD 91

Query: 67  SSGGDSCASEEEPTFDPG------YEPDWAVISTVRPQPCHSEPTRGAEPSCPQGS--WA 118
           SS         +     G      YE +W +++TV  +      T G  PS   G   W+
Sbjct: 92  SSSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFK--RKPHTNGDAPSHRNGKSKWS 149

Query: 119 FSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSP 178
           F  SL +LKSI+++K G+ W+YLV   +    LPALHFH+G ++ L+  L +Y++L  SP
Sbjct: 150 FLFSLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKLLIESLEKYVVLCESP 209

Query: 179 QDSRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFL-----------------QDPYS 221
           QD R  LV   + S LS SF +L   D+ +  ++   L                 +DPY+
Sbjct: 210 QDKRTLLVNCQNKS-LSQSFENL--LDEPAYGLIQAGLLDRRKLLWAIHHWKKIKKDPYT 266

Query: 222 TTFSSFSRVTNFFRGALQ---------PQPEGA--ASDLPP--PPDDEPEPGFEVISCVE 268
            T   FS+VTN+   +L+         P  E A   SD  P    + + EPGFEVI+ ++
Sbjct: 267 ATMIGFSKVTNYIFDSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRID 326

Query: 269 LGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLS 328
           LG RP V+R  PV+ EEW +++  EGR+  V  +K  IF GGLS +LR++AWKFLLGY  
Sbjct: 327 LGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFP 386

Query: 329 WEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKF 388
           W+ T EE     ++KTDEYFRMKLQWKS+S EQE+RNS L  YRSLIE+DV+RTDRTNKF
Sbjct: 387 WDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKF 446

Query: 389 YEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELV 448
           YEG +NPGL LL+DIL+TYCMY FDLGYVQGMSDLLSP+LYV++NEVDAFWCF  +M+ +
Sbjct: 447 YEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQM 506

Query: 449 QGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPD 508
             NFEE  + MK QL +L  LLR+LD   C +L+SQDSG L FCFRWLLI FKREF F D
Sbjct: 507 HQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLD 566

Query: 509 VLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVL 568
           +LRLWEV+WT LP  N HLL+ CAIL+ E+  +M   +G NEILKHINEL+MK+ VED+L
Sbjct: 567 ILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDIL 626

Query: 569 TRAEALHRQLTACPELPHNVQEILGL 594
            +AEA+  Q+  C ELP  V EILGL
Sbjct: 627 CKAEAISLQMVKCKELPQAVCEILGL 652


>gi|33563376 TBC1 domain family, member 16 [Homo sapiens]
          Length = 767

 Score =  201 bits (511), Expect = 2e-51
 Identities = 117/348 (33%), Positives = 181/348 (52%), Gaps = 14/348 (4%)

Query: 286 WARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTD 345
           W  H+   G++++  +L+  IF GG+  S+R E W FLL Y S E T+EE +A   +K  
Sbjct: 401 WLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRK 460

Query: 346 EYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILL 405
           EY  ++ +  S++PE+ R  +     +  +++DV RTDR N+F+ G +NP +  +  ILL
Sbjct: 461 EYSEIQQKRLSMTPEEHR--AFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILL 518

Query: 406 TYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGR 465
            Y +Y+  +GY QGMSDL++PIL  + +E D FWCF G M+          E M++QL  
Sbjct: 519 NYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLY 578

Query: 466 LLLLLRVLDPLLCDFLDS--QDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGP 523
           L  LLR+        L S  +D   + FC RWLL+ FKREFP  + LR+WE  W      
Sbjct: 579 LRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTD 638

Query: 524 NLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPE 583
             HL +  AI+ +  D ++     ++++L H   L M ++ E VL +A +L  Q    P 
Sbjct: 639 YFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPR 698

Query: 584 LPHNVQEIL----------GLAPPAEPHSPSPTASPLPLSPTRAPPTP 621
           +P ++ ++           G  P  E     P +   P   T   P+P
Sbjct: 699 IPCSLHDLCKLCGSGMWDSGSMPAVECTGHHPGSESCPYGGTVEMPSP 746


>gi|54607014 TBC1 domain family, member 25 [Homo sapiens]
          Length = 688

 Score =  187 bits (475), Expect = 3e-47
 Identities = 100/245 (40%), Positives = 144/245 (58%), Gaps = 8/245 (3%)

Query: 279 PPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKA 338
           PP+++ E+  ++  EG+L +  EL+ RI+ GG+ PSLR+  W++LL       T  E   
Sbjct: 197 PPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMD 256

Query: 339 HIRKKTDEYFRMKLQW-KSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPEN-PG 396
           ++++K+ EY ++K +W +  +PE       L   RS + +DV RTDR + +Y GPE+ P 
Sbjct: 257 YMKRKSREYEQLKSEWAQRANPED------LEFIRSTVLKDVLRTDRAHPYYAGPEDGPH 310

Query: 397 LGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQ 456
           L  L+D+L TY + H  + Y QGMSDL SPIL V+ +E  AF CFCG M+ +  NF    
Sbjct: 311 LRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDG 370

Query: 457 ETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVL 516
             M  +   L LLLR  DP    +L    +  L FC+RWLL+  KREF F D LR+ EV 
Sbjct: 371 RAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVT 430

Query: 517 WTGLP 521
           W+ LP
Sbjct: 431 WSSLP 435



 Score = 34.3 bits (77), Expect = 0.37
 Identities = 25/63 (39%), Positives = 31/63 (49%), Gaps = 7/63 (11%)

Query: 519 GLPGP------NLHLLVAC-AILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRA 571
           GLP P      N  +L  C AIL   RD +M +G   NE+  H + L  K  +  VL RA
Sbjct: 604 GLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRA 663

Query: 572 EAL 574
            AL
Sbjct: 664 RAL 666


>gi|23503283 TBC1 domain family, member 21 [Homo sapiens]
          Length = 336

 Score =  120 bits (300), Expect = 5e-27
 Identities = 87/312 (27%), Positives = 150/312 (48%), Gaps = 18/312 (5%)

Query: 275 VERGPPVTEEEWARHVGPEGRLQQVPE-LKNRIFSGGLSPSLRREAWKFLLGYLSWEGTA 333
           V+R PP+ + EW       G L +  + +   I   GL P +R EAWKFL GY SW+ + 
Sbjct: 21  VKRKPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHPFVRTEAWKFLTGYFSWQSSQ 80

Query: 334 EEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPE 393
           +E       +   Y  +   ++ + P  E  +      R+ I RD+       K Y+  +
Sbjct: 81  DERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFTETRNNIARDIQ------KIYD--K 132

Query: 394 NPGLGLLND------ILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMEL 447
           +P   +L D      ILL   + +    Y QG  +++     +++++ + FW F  F++ 
Sbjct: 133 DPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLFQFFLQK 192

Query: 448 VQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFP-F 506
            + +   +    K  L  L  L+  LDP+  + L  + +G++   F W    F+R F  F
Sbjct: 193 TEHSCVINIGVAKN-LDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSF 251

Query: 507 PDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVED 566
            DV RLWEVL TG P  N  +LVA ++L M R+ ++    G ++IL   N L + L  ++
Sbjct: 252 DDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLACNNL-IDLDADE 310

Query: 567 VLTRAEALHRQL 578
           +++ A  ++ +L
Sbjct: 311 LISAACVVYAEL 322


>gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo
            sapiens]
          Length = 1032

 Score =  118 bits (295), Expect = 2e-26
 Identities = 69/203 (33%), Positives = 110/203 (54%), Gaps = 7/203 (3%)

Query: 375  IERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNE 434
            IE+DV R DR N +Y  P N  L  L +I+ +Y   H ++GYVQGM DLL+P+L ++ +E
Sbjct: 823  IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 879

Query: 435  VDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFL-DSQDSGSLCFCF 493
              AF CF   M+ +  NF      M      +  L+++LD  L + +  + D     FC+
Sbjct: 880  ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 938

Query: 494  RWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLH--LLVACAILDMERDTLMLSGFGSNEI 551
            RW L+ FKRE  + DV  +WE +W      + H  L +A A++++ RD ++ +     +I
Sbjct: 939  RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 998

Query: 552  LKHINELTMKLSVEDVLTRAEAL 574
            +K  NE+  + + + VL  A  L
Sbjct: 999  IKFFNEMAERHNTKQVLKLARDL 1021



 Score = 37.0 bits (84), Expect = 0.057
 Identities = 19/69 (27%), Positives = 33/69 (47%), Gaps = 1/69 (1%)

Query: 269 LGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLS 328
           + P    + G  +T   W +++      ++  EL   I+ GG+ P +R+  W FLLG+  
Sbjct: 522 VSPDLPCDAGQGLTARIWEQYLHDSTSYEE-QELLRLIYYGGIQPEIRKAVWPFLLGHYQ 580

Query: 329 WEGTAEEHK 337
           +  T  E K
Sbjct: 581 FGMTETERK 589


>gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo
            sapiens]
          Length = 1093

 Score =  118 bits (295), Expect = 2e-26
 Identities = 69/203 (33%), Positives = 110/203 (54%), Gaps = 7/203 (3%)

Query: 375  IERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNE 434
            IE+DV R DR N +Y  P N  L  L +I+ +Y   H ++GYVQGM DLL+P+L ++ +E
Sbjct: 884  IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 940

Query: 435  VDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFL-DSQDSGSLCFCF 493
              AF CF   M+ +  NF      M      +  L+++LD  L + +  + D     FC+
Sbjct: 941  ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 999

Query: 494  RWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLH--LLVACAILDMERDTLMLSGFGSNEI 551
            RW L+ FKRE  + DV  +WE +W      + H  L +A A++++ RD ++ +     +I
Sbjct: 1000 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1059

Query: 552  LKHINELTMKLSVEDVLTRAEAL 574
            +K  NE+  + + + VL  A  L
Sbjct: 1060 IKFFNEMAERHNTKQVLKLARDL 1082



 Score = 37.7 bits (86), Expect = 0.033
 Identities = 26/105 (24%), Positives = 49/105 (46%), Gaps = 14/105 (13%)

Query: 269 LGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLS 328
           + P    + G  +T   W +++      ++  EL   I+ GG+ P +R+  W FLLG+  
Sbjct: 522 VSPDLPCDAGQGLTARIWEQYLHDSTSYEE-QELLRLIYYGGIQPEIRKAVWPFLLGHYQ 580

Query: 329 WEGTAEEHKAHIRKKTDE-----YFRMKLQW---KSVSPEQERRN 365
           +  T  E     RK+ DE     Y +   +W   +++  ++ER +
Sbjct: 581 FGMTETE-----RKEVDEQIHACYAQTMAEWLGCEAIVRQRERES 620


>gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sapiens]
          Length = 1087

 Score =  118 bits (295), Expect = 2e-26
 Identities = 69/203 (33%), Positives = 110/203 (54%), Gaps = 7/203 (3%)

Query: 375  IERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNE 434
            IE+DV R DR N +Y  P N  L  L +I+ +Y   H ++GYVQGM DLL+P+L ++ +E
Sbjct: 878  IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 934

Query: 435  VDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFL-DSQDSGSLCFCF 493
              AF CF   M+ +  NF      M      +  L+++LD  L + +  + D     FC+
Sbjct: 935  ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 993

Query: 494  RWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLH--LLVACAILDMERDTLMLSGFGSNEI 551
            RW L+ FKRE  + DV  +WE +W      + H  L +A A++++ RD ++ +     +I
Sbjct: 994  RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1053

Query: 552  LKHINELTMKLSVEDVLTRAEAL 574
            +K  NE+  + + + VL  A  L
Sbjct: 1054 IKFFNEMAERHNTKQVLKLARDL 1076



 Score = 37.0 bits (84), Expect = 0.057
 Identities = 19/69 (27%), Positives = 33/69 (47%), Gaps = 1/69 (1%)

Query: 269 LGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLS 328
           + P    + G  +T   W +++      ++  EL   I+ GG+ P +R+  W FLLG+  
Sbjct: 577 VSPDLPCDAGQGLTARIWEQYLHDSTSYEE-QELLRLIYYGGIQPEIRKAVWPFLLGHYQ 635

Query: 329 WEGTAEEHK 337
           +  T  E K
Sbjct: 636 FGMTETERK 644


>gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sapiens]
          Length = 1148

 Score =  118 bits (295), Expect = 2e-26
 Identities = 69/203 (33%), Positives = 110/203 (54%), Gaps = 7/203 (3%)

Query: 375  IERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNE 434
            IE+DV R DR N +Y  P N  L  L +I+ +Y   H ++GYVQGM DLL+P+L ++ +E
Sbjct: 939  IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 995

Query: 435  VDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFL-DSQDSGSLCFCF 493
              AF CF   M+ +  NF      M      +  L+++LD  L + +  + D     FC+
Sbjct: 996  ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 1054

Query: 494  RWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLH--LLVACAILDMERDTLMLSGFGSNEI 551
            RW L+ FKRE  + DV  +WE +W      + H  L +A A++++ RD ++ +     +I
Sbjct: 1055 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1114

Query: 552  LKHINELTMKLSVEDVLTRAEAL 574
            +K  NE+  + + + VL  A  L
Sbjct: 1115 IKFFNEMAERHNTKQVLKLARDL 1137



 Score = 37.7 bits (86), Expect = 0.033
 Identities = 26/105 (24%), Positives = 49/105 (46%), Gaps = 14/105 (13%)

Query: 269 LGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLS 328
           + P    + G  +T   W +++      ++  EL   I+ GG+ P +R+  W FLLG+  
Sbjct: 577 VSPDLPCDAGQGLTARIWEQYLHDSTSYEE-QELLRLIYYGGIQPEIRKAVWPFLLGHYQ 635

Query: 329 WEGTAEEHKAHIRKKTDE-----YFRMKLQW---KSVSPEQERRN 365
           +  T  E     RK+ DE     Y +   +W   +++  ++ER +
Sbjct: 636 FGMTETE-----RKEVDEQIHACYAQTMAEWLGCEAIVRQRERES 675


>gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo
           sapiens]
          Length = 1006

 Score =  115 bits (289), Expect = 1e-25
 Identities = 95/356 (26%), Positives = 154/356 (43%), Gaps = 45/356 (12%)

Query: 245 AASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPP------VTEEEWARHVGPEGRLQQ 298
           +  DL PP   +PE         +  P+P  E GP       V ++       P+  L  
Sbjct: 659 SVDDLEPPEPQDPE---------DSRPKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGL-- 707

Query: 299 VPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHK------AHIRKKTDEYFRMKL 352
            P  +N   + G+  SL        +G+   +G  EE        AH  ++  +  + K 
Sbjct: 708 -PSSRNYSVASGIQSSLDEGQ---SVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKP 763

Query: 353 QWKSVSPEQERRNSLLHGYR-----------SLIERDVSRTDRTNKFYEGPENPGLGLLN 401
           Q   +   +E        Y              I++DV R DR N +Y  P  P L  L 
Sbjct: 764 QAGELEAGEELAAVCAAAYTIELLDTVALNLHRIDKDVQRCDR-NYWYFTP--PNLERLR 820

Query: 402 DILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKR 461
           D++ +Y   H D+GYVQGM DLL+P+L  + N+  A+ CF   M+ +  NF      M  
Sbjct: 821 DVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNG-GAMDT 879

Query: 462 QLGRLLLLLRVLDPLLCDFL-DSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTG- 519
               +  L+++LD  L + +  + D     FC+RW L+ FKRE  + DV  +WEV+W   
Sbjct: 880 HFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAAR 939

Query: 520 -LPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEAL 574
            +   +  L +A A+++  R+ +  +     +I+K  NE       +++L  A  L
Sbjct: 940 HISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDL 995



 Score = 37.4 bits (85), Expect = 0.043
 Identities = 18/89 (20%), Positives = 45/89 (50%), Gaps = 1/89 (1%)

Query: 281 VTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHI 340
           +T++ W+++   +   +++ EL  +++ GG+   +R++ W FLLG+  +  + +E +   
Sbjct: 538 LTKDVWSKYQKDKKNYKEL-ELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVD 596

Query: 341 RKKTDEYFRMKLQWKSVSPEQERRNSLLH 369
                 Y ++  +WK+      +R    H
Sbjct: 597 AVVAARYQQVLAEWKACEVVVRQREREAH 625


>gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 1051

 Score =  115 bits (289), Expect = 1e-25
 Identities = 95/356 (26%), Positives = 154/356 (43%), Gaps = 45/356 (12%)

Query: 245  AASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPP------VTEEEWARHVGPEGRLQQ 298
            +  DL PP   +PE         +  P+P  E GP       V ++       P+  L  
Sbjct: 704  SVDDLEPPEPQDPE---------DSRPKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGL-- 752

Query: 299  VPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHK------AHIRKKTDEYFRMKL 352
             P  +N   + G+  SL        +G+   +G  EE        AH  ++  +  + K 
Sbjct: 753  -PSSRNYSVASGIQSSLDEGQ---SVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKP 808

Query: 353  QWKSVSPEQERRNSLLHGYR-----------SLIERDVSRTDRTNKFYEGPENPGLGLLN 401
            Q   +   +E        Y              I++DV R DR N +Y  P  P L  L 
Sbjct: 809  QAGELEAGEELAAVCAAAYTIELLDTVALNLHRIDKDVQRCDR-NYWYFTP--PNLERLR 865

Query: 402  DILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKR 461
            D++ +Y   H D+GYVQGM DLL+P+L  + N+  A+ CF   M+ +  NF      M  
Sbjct: 866  DVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNG-GAMDT 924

Query: 462  QLGRLLLLLRVLDPLLCDFL-DSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTG- 519
                +  L+++LD  L + +  + D     FC+RW L+ FKRE  + DV  +WEV+W   
Sbjct: 925  HFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAAR 984

Query: 520  -LPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEAL 574
             +   +  L +A A+++  R+ +  +     +I+K  NE       +++L  A  L
Sbjct: 985  HISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDL 1040



 Score = 37.4 bits (85), Expect = 0.043
 Identities = 18/89 (20%), Positives = 45/89 (50%), Gaps = 1/89 (1%)

Query: 281 VTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHI 340
           +T++ W+++   +   +++ EL  +++ GG+   +R++ W FLLG+  +  + +E +   
Sbjct: 583 LTKDVWSKYQKDKKNYKEL-ELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVD 641

Query: 341 RKKTDEYFRMKLQWKSVSPEQERRNSLLH 369
                 Y ++  +WK+      +R    H
Sbjct: 642 AVVAARYQQVLAEWKACEVVVRQREREAH 670


>gi|40068063 TBC1 domain family, member 22B [Homo sapiens]
          Length = 505

 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 63/249 (25%), Positives = 109/249 (43%), Gaps = 33/249 (13%)

Query: 310 GLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLH 369
           G+   +R   W+ L GYL      E  K  +++K +EYF    Q+     E+  +++   
Sbjct: 210 GVPREVRPITWRLLSGYLP--ANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDT--- 264

Query: 370 GYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILY 429
            YR  I  D+ RT+     ++ P    +     IL  + + H   GYVQG++DL++P   
Sbjct: 265 -YRQ-IHIDIPRTNPLIPLFQQPLVQEI--FERILFIWAIRHPASGYVQGINDLVTPFFV 320

Query: 430 V---------IQN--------------EVDAFWCFCGFMELVQGNFEESQETMKRQLGRL 466
           V         ++N              E D+FWC    ++ +Q N+  +Q  +++++  L
Sbjct: 321 VFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKAL 380

Query: 467 LLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPG-PNL 525
             L+  +D  + +     +   L F FRW+     RE P    +RLW+   +   G  + 
Sbjct: 381 EELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHF 440

Query: 526 HLLVACAIL 534
           HL V  A L
Sbjct: 441 HLYVCAAFL 449


>gi|190014603 TBC1 domain family, member 13 [Homo sapiens]
          Length = 400

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 48/161 (29%), Positives = 78/161 (48%), Gaps = 14/161 (8%)

Query: 403 ILLTYCMYHFDLGYVQGMSDLLSPILYVIQN----------EVDAFWCFCGFMELVQGNF 452
           IL  Y   +  + YVQGM++++ P+ Y              E D F+CF   M  ++ NF
Sbjct: 214 ILFIYAKLNPGIAYVQGMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNLMAEIRDNF 273

Query: 453 ----EESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPD 508
               ++SQ  +  ++ ++   L+  D  L   L  Q+     F FRWL +   +EF  PD
Sbjct: 274 IKSLDDSQCGITYKMEKVYSTLKDKDVELYLKLQEQNIKPQFFAFRWLTLLLSQEFLLPD 333

Query: 509 VLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSN 549
           V+R+W+ L+      +  LLV CA+L + R+ L+   F  N
Sbjct: 334 VIRIWDSLFADDNRFDFLLLVCCAMLMLIREQLLEGDFTVN 374


>gi|22507409 TBC1 domain family, member 22A [Homo sapiens]
          Length = 517

 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 66/271 (24%), Positives = 107/271 (39%), Gaps = 43/271 (15%)

Query: 291 GPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRM 350
           GP   L+++     R+   G+   +R   WK L GYL      +   A +++K  EYF  
Sbjct: 207 GPNTDLEEL----RRLSWSGIPKPVRPMTWKLLSGYLP--ANVDRRPATLQRKQKEYFAF 260

Query: 351 KLQWKSVSPEQERRNSLLHG--YRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYC 408
                 +    + RN  +H   YR  I  D+ R        +        +   IL  + 
Sbjct: 261 ------IEHYYDSRNDEVHQDTYRQ-IHIDIPRMSPEALILQPKVTE---IFERILFIWA 310

Query: 409 MYHFDLGYVQGMSDLLSPILYVI------------------------QNEVDAFWCFCGF 444
           + H   GYVQG++DL++P   V                           E D +WC    
Sbjct: 311 IRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKL 370

Query: 445 MELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREF 504
           ++ +Q N+  +Q  ++ ++  L  L+  +D  +   LD  +   L F FRW+     RE 
Sbjct: 371 LDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREV 430

Query: 505 PFPDVLRLWEVLWTGLPG-PNLHLLVACAIL 534
           P    +RLW+   +   G  + HL V  A L
Sbjct: 431 PLRCTIRLWDTYQSEPDGFSHFHLYVCAAFL 461


>gi|34147456 TBC domain-containing protein kinase-like [Homo
           sapiens]
          Length = 830

 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 65/274 (23%), Positives = 110/274 (40%), Gaps = 26/274 (9%)

Query: 375 IERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYV-IQN 433
           IE D+ R  + ++    PE  G      +L  + + H DL Y QG+  L +P LY+   N
Sbjct: 442 IEVDIPRCHQYDELLSSPE--GHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNN 499

Query: 434 EVDAFWCFCGFMELVQGNF--EESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCF 491
           E  A+ C   F+     NF  +++   ++  L     ++   DP L + L+        +
Sbjct: 500 EALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLY 559

Query: 492 CFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEI 551
              W L  F   FP   +  LW+ L  G    +    +  AIL   RD L+ +GF    +
Sbjct: 560 AIPWFLTMFTHVFPLHKIFHLWDTLLLG--NSSFPFCIGVAILQQLRDRLLANGFNECIL 617

Query: 552 L-KHINELTMKLSVEDVL-----TRAEALHRQLTACPELPHNVQEILGLAPPAEPHSPSP 605
           L   + E+ ++  V + +     T   A +RQ    P+             P+   S   
Sbjct: 618 LFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPK-------------PSSDSSGGR 664

Query: 606 TASPLPLSPTRAPPTPPPSTDTAPQPDSSLEILP 639
           +++P   +    PP    S ++ P  D   E+ P
Sbjct: 665 SSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSP 698


>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
          Length = 446

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 52/206 (25%), Positives = 82/206 (39%), Gaps = 24/206 (11%)

Query: 310 GLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLH 369
           G+  +LR   W  L G            AH+ +K       +L      P+         
Sbjct: 92  GIPSALRARCWPLLCG------------AHVCQKNSPGTYQELAEAPGDPQ--------- 130

Query: 370 GYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILY 429
            +   I RD+ R    ++ +  P+  G   L  +L  Y +Y  + GY Q    + + +L 
Sbjct: 131 -WMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLM 189

Query: 430 VIQNEVDAFWCFCGFMEL-VQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGS 488
            +  E +AFWC     E+ + G +    E ++      + LLR L P +   L     G 
Sbjct: 190 HLPPE-EAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGP 248

Query: 489 LCFCFRWLLIWFKREFPFPDVLRLWE 514
           L +   W L  F R  PFP VLR+W+
Sbjct: 249 LLYLPEWFLCLFARSLPFPTVLRVWD 274


>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
          Length = 963

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 63/295 (21%), Positives = 115/295 (38%), Gaps = 25/295 (8%)

Query: 252 PPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQV--PELKNRIFSG 309
           P DDE E     +  ++L      E     T  +W  +       + +  PELKN I   
Sbjct: 603 PEDDEEEKLVAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNLI-RA 661

Query: 310 GLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLH 369
           G+    R + WK+ +         + H    +  T+      L  K++  +         
Sbjct: 662 GIPHEHRSKVWKWCV---------DRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQ--- 709

Query: 370 GYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILY 429
                IE D+ RT   NK Y  P + G+  L ++LL +   + D+GY QG++ L++  L 
Sbjct: 710 -----IELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALL 764

Query: 430 VIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLL--LLRVLDPLLCDFLDSQDSG 487
            ++ E DAFWC    +E+       ++  +  Q+ + +   L+    P L    +     
Sbjct: 765 YLEQE-DAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVD 823

Query: 488 SLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLM 542
                F W L+ F        + ++W+       GP +    A A+   + + ++
Sbjct: 824 YTLITFNWFLVVFVDSVVSDILFKIWDSFL--YEGPKVIFRFALALFKYKEEEIL 876


>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
          Length = 914

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 63/295 (21%), Positives = 115/295 (38%), Gaps = 25/295 (8%)

Query: 252 PPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQV--PELKNRIFSG 309
           P DDE E     +  ++L      E     T  +W  +       + +  PELKN I   
Sbjct: 603 PEDDEEEKLVAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNLI-RA 661

Query: 310 GLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLH 369
           G+    R + WK+ +         + H    +  T+      L  K++  +         
Sbjct: 662 GIPHEHRSKVWKWCV---------DRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQ--- 709

Query: 370 GYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILY 429
                IE D+ RT   NK Y  P + G+  L ++LL +   + D+GY QG++ L++  L 
Sbjct: 710 -----IELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALL 764

Query: 430 VIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLL--LLRVLDPLLCDFLDSQDSG 487
            ++ E DAFWC    +E+       ++  +  Q+ + +   L+    P L    +     
Sbjct: 765 YLEQE-DAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVD 823

Query: 488 SLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLM 542
                F W L+ F        + ++W+       GP +    A A+   + + ++
Sbjct: 824 YTLITFNWFLVVFVDSVVSDILFKIWDSFL--YEGPKVIFRFALALFKYKEEEIL 876


>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
          Length = 508

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 78/343 (22%), Positives = 133/343 (38%), Gaps = 55/343 (16%)

Query: 310 GLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLH 369
           G+ PSLR  AW++L G           K  +++   ++  + +     SP   +      
Sbjct: 111 GIPPSLRGRAWQYLSG----------GKVKLQQNPGKFDELDM-----SPGDPK------ 149

Query: 370 GYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILY 429
            +  +IERD+ R    ++ +      G   L  +L  Y +Y  + GY Q  + + + +L 
Sbjct: 150 -WLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLM 208

Query: 430 VIQNEVDAFWCFCGFME-LVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGS 488
            +  E  AFWC     E  + G + E  E ++     L  LL+ + P+    L  Q    
Sbjct: 209 HMPAE-QAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDP 267

Query: 489 LCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILD--MERDTLMLSGF 546
           L +   W +  F R  P+  VLR+W++ +    G  +   V   +L   +     + +  
Sbjct: 268 LLYMTEWFMCAFSRTLPWSSVLRVWDMFF--CEGVKIIFRVGLVLLKHALGSPEKVKACQ 325

Query: 547 GSNEILKHINELTMKLSVEDVLTR----AEALHRQL-------------------TACPE 583
           G  E ++ +  L+ K+  E  L +         RQ+                      P 
Sbjct: 326 GQYETIERLRSLSPKIMQEAFLVQEVVELPVTERQIEREHLIQLRRWQETRGELQCRSPP 385

Query: 584 LPHNVQEILGLAPPAEPH-SPSPTAS-PL--PLSPTRAPPTPP 622
             H  + IL   P   P   PSP+   PL  PL  ++A P PP
Sbjct: 386 RLHGAKAILDAEPGPRPALQPSPSIRLPLDAPLPGSKAKPKPP 428


>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
          Length = 828

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 57/235 (24%), Positives = 96/235 (40%), Gaps = 27/235 (11%)

Query: 285 EWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKT 344
           +W + +    + +   +   RI+ G +   LR E W  LL          E      +  
Sbjct: 76  KWLKMLKGWEKYKNTEKFHRRIYKG-IPLQLRGEVWALLL----------EIPKMKEETR 124

Query: 345 DEYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDIL 404
           D Y ++K + +  SP+  +           I+ DV+RT R +  +          L  +L
Sbjct: 125 DLYSKLKHRARGCSPDIRQ-----------IDLDVNRTFRDHIMFRDRYGVKQQSLFHVL 173

Query: 405 LTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWC----FCGFMELVQGNFEESQETMK 460
             Y +Y+ ++GY QGMS  ++ +L +  NE DAFW     F G    + G F +    + 
Sbjct: 174 AAYSIYNTEVGYCQGMSQ-ITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLL 232

Query: 461 RQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEV 515
           R       +L      L   LDSQ+  +  +  +W    F    PF   LR+W++
Sbjct: 233 RFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDI 287


>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
          Length = 845

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 57/235 (24%), Positives = 96/235 (40%), Gaps = 27/235 (11%)

Query: 285 EWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKT 344
           +W + +    + +   +   RI+ G +   LR E W  LL          E      +  
Sbjct: 93  KWLKMLKGWEKYKNTEKFHRRIYKG-IPLQLRGEVWALLL----------EIPKMKEETR 141

Query: 345 DEYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDIL 404
           D Y ++K + +  SP+  +           I+ DV+RT R +  +          L  +L
Sbjct: 142 DLYSKLKHRARGCSPDIRQ-----------IDLDVNRTFRDHIMFRDRYGVKQQSLFHVL 190

Query: 405 LTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWC----FCGFMELVQGNFEESQETMK 460
             Y +Y+ ++GY QGMS  ++ +L +  NE DAFW     F G    + G F +    + 
Sbjct: 191 AAYSIYNTEVGYCQGMSQ-ITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLL 249

Query: 461 RQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEV 515
           R       +L      L   LDSQ+  +  +  +W    F    PF   LR+W++
Sbjct: 250 RFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDI 304


>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
          Length = 1069

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 77/321 (23%), Positives = 128/321 (39%), Gaps = 55/321 (17%)

Query: 240 PQPEGAASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQV 299
           PQ    +S +P PP+D+ E         E    P +     V++E   + +   G L   
Sbjct: 497 PQSGSQSSVIPSPPEDDEE---------EDNDEPLLSGSGDVSKECAEKILETWGELLSK 547

Query: 300 --------PELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMK 351
                   P+  + +   G+  +LR E W+ L G  + +   E+++  I K+        
Sbjct: 548 WHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKE-------- 599

Query: 352 LQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYH 411
                 SP+            S I RD++RT   + +++     G   L  I   Y +Y 
Sbjct: 600 ------SPQD-----------SAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYD 642

Query: 412 FDLGYVQGMSDLLSPILYVIQNEVDAFWCFC------GFMELVQGNFEESQETMKRQLGR 465
            ++GY QG S  L+ +L +   E  AF          G  EL + NFE+       QL R
Sbjct: 643 EEIGYCQGQS-FLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFED-LHCKFYQLER 700

Query: 466 LLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNL 525
             L+   +  L   FLD      + +  +W L  F  +FP   V  + ++L     G ++
Sbjct: 701 --LMQEYIPDLYNHFLDISLEAHM-YASQWFLTLFTAKFPLYMVFHIIDLLL--CEGISV 755

Query: 526 HLLVACAILDMERDTLMLSGF 546
              VA  +L   +D L+L+ F
Sbjct: 756 IFNVALGLLKTSKDDLLLTDF 776


>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
           sapiens]
          Length = 815

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 67/302 (22%), Positives = 116/302 (38%), Gaps = 41/302 (13%)

Query: 252 PPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGP-EGRLQQVPELKNRIFSGG 310
           P DDE E   E  + +  G     +  P      W   +G     L   P+  + +   G
Sbjct: 481 PQDDEAEE--ESDNELSSGTGDVSKDCPEKILYSWGELLGKWHSNLGARPKGLSTLVKSG 538

Query: 311 LSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHG 370
           +  +LR E W+ L G    +   + ++  I K + +                        
Sbjct: 539 VPEALRAEVWQLLAGCHDNQAMLDRYRILITKDSAQ------------------------ 574

Query: 371 YRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYV 430
             S+I RD+ RT   + +++     G   L  I   Y +Y  D+GY QG S  L+ +L +
Sbjct: 575 -ESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQS-FLAAVLLL 632

Query: 431 IQNEVDAFWCFC------GFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQ 484
              E  AF          G  +L + NFE+    +  +  +L  L++   P L       
Sbjct: 633 HMPEEQAFCVLVKIMYDYGLRDLYRNNFED----LHCKFYQLERLMQEQLPDLHSHFSDL 688

Query: 485 DSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLS 544
           +  +  +  +W L  F  +FP   V  + ++L     G N+   VA A+L   ++ L+ +
Sbjct: 689 NLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLL--CEGLNIIFHVALALLKTSKEDLLQA 746

Query: 545 GF 546
            F
Sbjct: 747 DF 748


>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
            [Homo sapiens]
          Length = 1168

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 52/220 (23%), Positives = 98/220 (44%), Gaps = 11/220 (5%)

Query: 330  EGTAEEHKAHIRKKTDEYFRMKLQWKSVS-----PEQERRNSLLHGYRSLIERDVSRTDR 384
            +G    H+  I K   E F +K Q+ S       P +E    L     +++  D+ RT  
Sbjct: 799  QGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILI-DLGRTFP 857

Query: 385  TNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWC--FC 442
            T+ ++      G   L +IL  Y +   ++GY QG+S  ++ IL +  +E +AF    F 
Sbjct: 858  THPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLS-FVAGILLLHMSEEEAFKMLKFL 916

Query: 443  GFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKR 502
             F   ++  +      ++ Q+ +L  LL      L + L+  + G   +   W L  F  
Sbjct: 917  MFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFAS 976

Query: 503  EFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLM 542
            +FP   V R++++++  L G  +   VA ++L   +  ++
Sbjct: 977  QFPLGFVARVFDMIF--LQGTEVIFKVALSLLGSHKPLIL 1014


>gi|229577000 ecotropic viral integration site 5-like isoform 1
           [Homo sapiens]
          Length = 805

 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 42/174 (24%), Positives = 80/174 (45%), Gaps = 11/174 (6%)

Query: 374 LIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQN 433
           LI RD++RT   ++F++G ++ G  +L +++  Y +   ++GY QG + ++  +L  +  
Sbjct: 153 LIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPE 212

Query: 434 EVDAFWCFCGFMELVQGN-----FEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGS 488
           E      FC F+ L+Q       F+ S   +   + +   +L+   P L     SQ   +
Sbjct: 213 EE----AFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHT 268

Query: 489 LCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLM 542
             +   W L  F   FP P   R++++      G  +   V  A+L + +  LM
Sbjct: 269 SMYASSWFLTLFLTTFPLPVATRVFDIFM--YEGLEIVFRVGLALLQVNQAELM 320


>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
           sapiens]
          Length = 794

 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 42/174 (24%), Positives = 80/174 (45%), Gaps = 11/174 (6%)

Query: 374 LIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQN 433
           LI RD++RT   ++F++G ++ G  +L +++  Y +   ++GY QG + ++  +L  +  
Sbjct: 153 LIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPE 212

Query: 434 EVDAFWCFCGFMELVQGN-----FEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGS 488
           E      FC F+ L+Q       F+ S   +   + +   +L+   P L     SQ   +
Sbjct: 213 EE----AFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHT 268

Query: 489 LCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLM 542
             +   W L  F   FP P   R++++      G  +   V  A+L + +  LM
Sbjct: 269 SMYASSWFLTLFLTTFPLPVATRVFDIFM--YEGLEIVFRVGLALLQVNQAELM 320


>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
          Length = 810

 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 42/176 (23%), Positives = 81/176 (46%), Gaps = 15/176 (8%)

Query: 374 LIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQN 433
           LI RD++RT   + F++  ++ G  +L +++  Y +   ++GY QG + ++  +L  +  
Sbjct: 201 LIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPE 260

Query: 434 EVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFL-------DSQDS 486
           E      FC F++L+Q      +E  K  +  L L +   + ++ + L        SQ  
Sbjct: 261 EE----AFCVFVKLMQD--YRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSF 314

Query: 487 GSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLM 542
            +  +   W L  F   FP P   R++++  +   G  +   V  A+L M +  LM
Sbjct: 315 HTSMYASSWFLTIFLTTFPLPIATRIFDIFMS--EGLEIVFRVGLALLQMNQAELM 368


>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
          Length = 808

 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 51/201 (25%), Positives = 83/201 (41%), Gaps = 12/201 (5%)

Query: 374 LIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQN 433
           +IE+D+ R    ++ +      G   L  IL  Y +Y  D GY Q  + + + +L  +  
Sbjct: 402 VIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPA 461

Query: 434 EVDAFWCFCGFME-LVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFC 492
           E  AFWC     +  + G +    E ++        LLR   PL    L  Q    + + 
Sbjct: 462 E-QAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYM 520

Query: 493 FRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTL-----MLSGFG 547
             W +  F R  P+  VLR+W++ +    G  +   VA  +L   R TL     + S  G
Sbjct: 521 TEWFMCIFARTLPWASVLRVWDMFF--CEGVKIIFRVALVLL---RHTLGSVEKLRSCQG 575

Query: 548 SNEILKHINELTMKLSVEDVL 568
             E ++ +  L  +   ED L
Sbjct: 576 MYETMEQLRNLPQQCMQEDFL 596


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.137    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,948,821
Number of Sequences: 37866
Number of extensions: 1815526
Number of successful extensions: 20834
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 224
Number of HSP's successfully gapped in prelim test: 454
Number of HSP's that attempted gapping in prelim test: 14005
Number of HSP's gapped (non-prelim): 5785
length of query: 648
length of database: 18,247,518
effective HSP length: 109
effective length of query: 539
effective length of database: 14,120,124
effective search space: 7610746836
effective search space used: 7610746836
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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