BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|13375952 TBC1 domain family, member 17 [Homo sapiens] (648 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|13375952 TBC1 domain family, member 17 [Homo sapiens] 1335 0.0 gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens] 597 e-170 gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens] 596 e-170 gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens] 586 e-167 gi|33563376 TBC1 domain family, member 16 [Homo sapiens] 201 2e-51 gi|54607014 TBC1 domain family, member 25 [Homo sapiens] 187 3e-47 gi|23503283 TBC1 domain family, member 21 [Homo sapiens] 120 5e-27 gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sa... 118 2e-26 gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sa... 118 2e-26 gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sap... 118 2e-26 gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sap... 118 2e-26 gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo sa... 115 1e-25 gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo sa... 115 1e-25 gi|40068063 TBC1 domain family, member 22B [Homo sapiens] 77 6e-14 gi|190014603 TBC1 domain family, member 13 [Homo sapiens] 74 3e-13 gi|22507409 TBC1 domain family, member 22A [Homo sapiens] 70 5e-12 gi|34147456 TBC domain-containing protein kinase-like [Homo sapi... 68 3e-11 gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 66 1e-10 gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 65 1e-10 gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 65 1e-10 gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 64 3e-10 gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 61 3e-09 gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 61 3e-09 gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 61 4e-09 gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 54 3e-07 gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 54 4e-07 gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 53 8e-07 gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 53 8e-07 gi|68299759 ecotropic viral integration site 5 [Homo sapiens] 53 8e-07 gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 53 8e-07 >gi|13375952 TBC1 domain family, member 17 [Homo sapiens] Length = 648 Score = 1335 bits (3455), Expect = 0.0 Identities = 648/648 (100%), Positives = 648/648 (100%) Query: 1 MEGAGYRVVFEKGGVYLHTSAKKYQDRDSLIAGVIRVVEKDNDVLLHWAPVEEAGDSTQI 60 MEGAGYRVVFEKGGVYLHTSAKKYQDRDSLIAGVIRVVEKDNDVLLHWAPVEEAGDSTQI Sbjct: 1 MEGAGYRVVFEKGGVYLHTSAKKYQDRDSLIAGVIRVVEKDNDVLLHWAPVEEAGDSTQI 60 Query: 61 LFSKKDSSGGDSCASEEEPTFDPGYEPDWAVISTVRPQPCHSEPTRGAEPSCPQGSWAFS 120 LFSKKDSSGGDSCASEEEPTFDPGYEPDWAVISTVRPQPCHSEPTRGAEPSCPQGSWAFS Sbjct: 61 LFSKKDSSGGDSCASEEEPTFDPGYEPDWAVISTVRPQPCHSEPTRGAEPSCPQGSWAFS 120 Query: 121 VSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSPQD 180 VSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSPQD Sbjct: 121 VSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSPQD 180 Query: 181 SRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQP 240 SRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQP Sbjct: 181 SRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQP 240 Query: 241 QPEGAASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVP 300 QPEGAASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVP Sbjct: 241 QPEGAASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVP 300 Query: 301 ELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPE 360 ELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPE Sbjct: 301 ELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPE 360 Query: 361 QERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGM 420 QERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGM Sbjct: 361 QERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGM 420 Query: 421 SDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDF 480 SDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDF Sbjct: 421 SDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDF 480 Query: 481 LDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDT 540 LDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDT Sbjct: 481 LDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDT 540 Query: 541 LMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELPHNVQEILGLAPPAEP 600 LMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELPHNVQEILGLAPPAEP Sbjct: 541 LMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELPHNVQEILGLAPPAEP 600 Query: 601 HSPSPTASPLPLSPTRAPPTPPPSTDTAPQPDSSLEILPEEEDEGADS 648 HSPSPTASPLPLSPTRAPPTPPPSTDTAPQPDSSLEILPEEEDEGADS Sbjct: 601 HSPSPTASPLPLSPTRAPPTPPPSTDTAPQPDSSLEILPEEEDEGADS 648 >gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens] Length = 696 Score = 597 bits (1539), Expect = e-170 Identities = 310/609 (50%), Positives = 415/609 (68%), Gaps = 26/609 (4%) Query: 7 RVVFEKGGVYLHTSAKKYQDRDSLIAGVIRVVEKDNDVLLHWAPVEEAGDSTQILFSKKD 66 ++++E+ GVY+H+S K D+D LI+G++RV+EKD +V++ W P+++A DS+ IL+++KD Sbjct: 32 KIIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWRPLDDALDSSSILYARKD 91 Query: 67 SSGGDSCASEEEPTFDPG------YEPDWAVISTVRPQPCHSEPTRGAEPSCPQGS--WA 118 SS + G YE +W +++TV + T G PS G W+ Sbjct: 92 SSSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFK--RKPHTNGDAPSHRNGKSKWS 149 Query: 119 FSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSP 178 F SL +LKSI+++K G+ W+YLV + LPALHFH+G ++ L+ L +Y++L SP Sbjct: 150 FLFSLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKLLIESLEKYVVLCESP 209 Query: 179 QDSRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGAL 238 QD R LV + S LS SF +L D+ + ++ + +DPY+ T FS+VTN+ +L Sbjct: 210 QDKRTLLVNCQNKS-LSQSFENL--LDEPAYGLIQKIKKDPYTATMIGFSKVTNYIFDSL 266 Query: 239 Q---------PQPEGA--ASDLPP--PPDDEPEPGFEVISCVELGPRPTVERGPPVTEEE 285 + P E A SD P + + EPGFEVI+ ++LG RP V+R PV+ EE Sbjct: 267 RGSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEE 326 Query: 286 WARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTD 345 W +++ EGR+ V +K IF GGLS +LR++AWKFLLGY W+ T EE ++KTD Sbjct: 327 WTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTD 386 Query: 346 EYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILL 405 EYFRMKLQWKS+S EQE+RNS L YRSLIE+DV+RTDRTNKFYEG +NPGL LL+DIL+ Sbjct: 387 EYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILM 446 Query: 406 TYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGR 465 TYCMY FDLGYVQGMSDLLSP+LYV++NEVDAFWCF +M+ + NFEE + MK QL + Sbjct: 447 TYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQ 506 Query: 466 LLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNL 525 L LLR+LD C +L+SQDSG L FCFRWLLI FKREF F D+LRLWEV+WT LP N Sbjct: 507 LSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNF 566 Query: 526 HLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELP 585 HLL+ CAIL+ E+ +M +G NEILKHINEL+MK+ VED+L +AEA+ Q+ C ELP Sbjct: 567 HLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELP 626 Query: 586 HNVQEILGL 594 V EILGL Sbjct: 627 QAVCEILGL 635 >gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens] Length = 682 Score = 596 bits (1537), Expect = e-170 Identities = 310/608 (50%), Positives = 414/608 (68%), Gaps = 26/608 (4%) Query: 8 VVFEKGGVYLHTSAKKYQDRDSLIAGVIRVVEKDNDVLLHWAPVEEAGDSTQILFSKKDS 67 +++E+ GVY+H+S K D+D LI+G++RV+EKD +V++ W P+++A DS+ IL+++KDS Sbjct: 19 IIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWRPLDDALDSSSILYARKDS 78 Query: 68 SGGDSCASEEEPTFDPG------YEPDWAVISTVRPQPCHSEPTRGAEPSCPQGS--WAF 119 S + G YE +W +++TV + T G PS G W+F Sbjct: 79 SSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFK--RKPHTNGDAPSHRNGKSKWSF 136 Query: 120 SVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSPQ 179 SL +LKSI+++K G+ W+YLV + LPALHFH+G ++ L+ L +Y++L SPQ Sbjct: 137 LFSLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKLLIESLEKYVVLCESPQ 196 Query: 180 DSRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQ 239 D R LV + S LS SF +L D+ + ++ + +DPY+ T FS+VTN+ +L+ Sbjct: 197 DKRTLLVNCQNKS-LSQSFENL--LDEPAYGLIQKIKKDPYTATMIGFSKVTNYIFDSLR 253 Query: 240 ---------PQPEGA--ASDLPP--PPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEW 286 P E A SD P + + EPGFEVI+ ++LG RP V+R PV+ EEW Sbjct: 254 GSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEW 313 Query: 287 ARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDE 346 +++ EGR+ V +K IF GGLS +LR++AWKFLLGY W+ T EE ++KTDE Sbjct: 314 TKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDE 373 Query: 347 YFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLT 406 YFRMKLQWKS+S EQE+RNS L YRSLIE+DV+RTDRTNKFYEG +NPGL LL+DIL+T Sbjct: 374 YFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMT 433 Query: 407 YCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRL 466 YCMY FDLGYVQGMSDLLSP+LYV++NEVDAFWCF +M+ + NFEE + MK QL +L Sbjct: 434 YCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQL 493 Query: 467 LLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLH 526 LLR+LD C +L+SQDSG L FCFRWLLI FKREF F D+LRLWEV+WT LP N H Sbjct: 494 STLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFH 553 Query: 527 LLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELPH 586 LL+ CAIL+ E+ +M +G NEILKHINEL+MK+ VED+L +AEA+ Q+ C ELP Sbjct: 554 LLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQ 613 Query: 587 NVQEILGL 594 V EILGL Sbjct: 614 AVCEILGL 621 >gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens] Length = 713 Score = 586 bits (1511), Expect = e-167 Identities = 311/626 (49%), Positives = 415/626 (66%), Gaps = 43/626 (6%) Query: 7 RVVFEKGGVYLHTSAKKYQDRDSLIAGVIRVVEKDNDVLLHWAPVEEAGDSTQILFSKKD 66 ++++E+ GVY+H+S K D+D LI+G++RV+EKD +V++ W P+++A DS+ IL+++KD Sbjct: 32 KIIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEVIVDWRPLDDALDSSSILYARKD 91 Query: 67 SSGGDSCASEEEPTFDPG------YEPDWAVISTVRPQPCHSEPTRGAEPSCPQGS--WA 118 SS + G YE +W +++TV + T G PS G W+ Sbjct: 92 SSSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFK--RKPHTNGDAPSHRNGKSKWS 149 Query: 119 FSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSP 178 F SL +LKSI+++K G+ W+YLV + LPALHFH+G ++ L+ L +Y++L SP Sbjct: 150 FLFSLTDLKSIKQNKEGMGWSYLVFCLKDDVVLPALHFHQGDSKLLIESLEKYVVLCESP 209 Query: 179 QDSRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFL-----------------QDPYS 221 QD R LV + S LS SF +L D+ + ++ L +DPY+ Sbjct: 210 QDKRTLLVNCQNKS-LSQSFENL--LDEPAYGLIQAGLLDRRKLLWAIHHWKKIKKDPYT 266 Query: 222 TTFSSFSRVTNFFRGALQ---------PQPEGA--ASDLPP--PPDDEPEPGFEVISCVE 268 T FS+VTN+ +L+ P E A SD P + + EPGFEVI+ ++ Sbjct: 267 ATMIGFSKVTNYIFDSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRID 326 Query: 269 LGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLS 328 LG RP V+R PV+ EEW +++ EGR+ V +K IF GGLS +LR++AWKFLLGY Sbjct: 327 LGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFP 386 Query: 329 WEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKF 388 W+ T EE ++KTDEYFRMKLQWKS+S EQE+RNS L YRSLIE+DV+RTDRTNKF Sbjct: 387 WDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKF 446 Query: 389 YEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELV 448 YEG +NPGL LL+DIL+TYCMY FDLGYVQGMSDLLSP+LYV++NEVDAFWCF +M+ + Sbjct: 447 YEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQM 506 Query: 449 QGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPD 508 NFEE + MK QL +L LLR+LD C +L+SQDSG L FCFRWLLI FKREF F D Sbjct: 507 HQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLD 566 Query: 509 VLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVL 568 +LRLWEV+WT LP N HLL+ CAIL+ E+ +M +G NEILKHINEL+MK+ VED+L Sbjct: 567 ILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDIL 626 Query: 569 TRAEALHRQLTACPELPHNVQEILGL 594 +AEA+ Q+ C ELP V EILGL Sbjct: 627 CKAEAISLQMVKCKELPQAVCEILGL 652 >gi|33563376 TBC1 domain family, member 16 [Homo sapiens] Length = 767 Score = 201 bits (511), Expect = 2e-51 Identities = 117/348 (33%), Positives = 181/348 (52%), Gaps = 14/348 (4%) Query: 286 WARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTD 345 W H+ G++++ +L+ IF GG+ S+R E W FLL Y S E T+EE +A +K Sbjct: 401 WLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRK 460 Query: 346 EYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILL 405 EY ++ + S++PE+ R + + +++DV RTDR N+F+ G +NP + + ILL Sbjct: 461 EYSEIQQKRLSMTPEEHR--AFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILL 518 Query: 406 TYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGR 465 Y +Y+ +GY QGMSDL++PIL + +E D FWCF G M+ E M++QL Sbjct: 519 NYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLY 578 Query: 466 LLLLLRVLDPLLCDFLDS--QDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGP 523 L LLR+ L S +D + FC RWLL+ FKREFP + LR+WE W Sbjct: 579 LRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTD 638 Query: 524 NLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPE 583 HL + AI+ + D ++ ++++L H L M ++ E VL +A +L Q P Sbjct: 639 YFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPR 698 Query: 584 LPHNVQEIL----------GLAPPAEPHSPSPTASPLPLSPTRAPPTP 621 +P ++ ++ G P E P + P T P+P Sbjct: 699 IPCSLHDLCKLCGSGMWDSGSMPAVECTGHHPGSESCPYGGTVEMPSP 746 >gi|54607014 TBC1 domain family, member 25 [Homo sapiens] Length = 688 Score = 187 bits (475), Expect = 3e-47 Identities = 100/245 (40%), Positives = 144/245 (58%), Gaps = 8/245 (3%) Query: 279 PPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKA 338 PP+++ E+ ++ EG+L + EL+ RI+ GG+ PSLR+ W++LL T E Sbjct: 197 PPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMD 256 Query: 339 HIRKKTDEYFRMKLQW-KSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPEN-PG 396 ++++K+ EY ++K +W + +PE L RS + +DV RTDR + +Y GPE+ P Sbjct: 257 YMKRKSREYEQLKSEWAQRANPED------LEFIRSTVLKDVLRTDRAHPYYAGPEDGPH 310 Query: 397 LGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQ 456 L L+D+L TY + H + Y QGMSDL SPIL V+ +E AF CFCG M+ + NF Sbjct: 311 LRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDG 370 Query: 457 ETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVL 516 M + L LLLR DP +L + L FC+RWLL+ KREF F D LR+ EV Sbjct: 371 RAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVT 430 Query: 517 WTGLP 521 W+ LP Sbjct: 431 WSSLP 435 Score = 34.3 bits (77), Expect = 0.37 Identities = 25/63 (39%), Positives = 31/63 (49%), Gaps = 7/63 (11%) Query: 519 GLPGP------NLHLLVAC-AILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRA 571 GLP P N +L C AIL RD +M +G NE+ H + L K + VL RA Sbjct: 604 GLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRA 663 Query: 572 EAL 574 AL Sbjct: 664 RAL 666 >gi|23503283 TBC1 domain family, member 21 [Homo sapiens] Length = 336 Score = 120 bits (300), Expect = 5e-27 Identities = 87/312 (27%), Positives = 150/312 (48%), Gaps = 18/312 (5%) Query: 275 VERGPPVTEEEWARHVGPEGRLQQVPE-LKNRIFSGGLSPSLRREAWKFLLGYLSWEGTA 333 V+R PP+ + EW G L + + + I GL P +R EAWKFL GY SW+ + Sbjct: 21 VKRKPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHPFVRTEAWKFLTGYFSWQSSQ 80 Query: 334 EEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPE 393 +E + Y + ++ + P E + R+ I RD+ K Y+ + Sbjct: 81 DERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFTETRNNIARDIQ------KIYD--K 132 Query: 394 NPGLGLLND------ILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMEL 447 +P +L D ILL + + Y QG +++ +++++ + FW F F++ Sbjct: 133 DPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLFQFFLQK 192 Query: 448 VQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFP-F 506 + + + K L L L+ LDP+ + L + +G++ F W F+R F F Sbjct: 193 TEHSCVINIGVAKN-LDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSF 251 Query: 507 PDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVED 566 DV RLWEVL TG P N +LVA ++L M R+ ++ G ++IL N L + L ++ Sbjct: 252 DDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLACNNL-IDLDADE 310 Query: 567 VLTRAEALHRQL 578 +++ A ++ +L Sbjct: 311 LISAACVVYAEL 322 >gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sapiens] Length = 1032 Score = 118 bits (295), Expect = 2e-26 Identities = 69/203 (33%), Positives = 110/203 (54%), Gaps = 7/203 (3%) Query: 375 IERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNE 434 IE+DV R DR N +Y P N L L +I+ +Y H ++GYVQGM DLL+P+L ++ +E Sbjct: 823 IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 879 Query: 435 VDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFL-DSQDSGSLCFCF 493 AF CF M+ + NF M + L+++LD L + + + D FC+ Sbjct: 880 ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 938 Query: 494 RWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLH--LLVACAILDMERDTLMLSGFGSNEI 551 RW L+ FKRE + DV +WE +W + H L +A A++++ RD ++ + +I Sbjct: 939 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 998 Query: 552 LKHINELTMKLSVEDVLTRAEAL 574 +K NE+ + + + VL A L Sbjct: 999 IKFFNEMAERHNTKQVLKLARDL 1021 Score = 37.0 bits (84), Expect = 0.057 Identities = 19/69 (27%), Positives = 33/69 (47%), Gaps = 1/69 (1%) Query: 269 LGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLS 328 + P + G +T W +++ ++ EL I+ GG+ P +R+ W FLLG+ Sbjct: 522 VSPDLPCDAGQGLTARIWEQYLHDSTSYEE-QELLRLIYYGGIQPEIRKAVWPFLLGHYQ 580 Query: 329 WEGTAEEHK 337 + T E K Sbjct: 581 FGMTETERK 589 >gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sapiens] Length = 1093 Score = 118 bits (295), Expect = 2e-26 Identities = 69/203 (33%), Positives = 110/203 (54%), Gaps = 7/203 (3%) Query: 375 IERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNE 434 IE+DV R DR N +Y P N L L +I+ +Y H ++GYVQGM DLL+P+L ++ +E Sbjct: 884 IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 940 Query: 435 VDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFL-DSQDSGSLCFCF 493 AF CF M+ + NF M + L+++LD L + + + D FC+ Sbjct: 941 ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 999 Query: 494 RWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLH--LLVACAILDMERDTLMLSGFGSNEI 551 RW L+ FKRE + DV +WE +W + H L +A A++++ RD ++ + +I Sbjct: 1000 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1059 Query: 552 LKHINELTMKLSVEDVLTRAEAL 574 +K NE+ + + + VL A L Sbjct: 1060 IKFFNEMAERHNTKQVLKLARDL 1082 Score = 37.7 bits (86), Expect = 0.033 Identities = 26/105 (24%), Positives = 49/105 (46%), Gaps = 14/105 (13%) Query: 269 LGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLS 328 + P + G +T W +++ ++ EL I+ GG+ P +R+ W FLLG+ Sbjct: 522 VSPDLPCDAGQGLTARIWEQYLHDSTSYEE-QELLRLIYYGGIQPEIRKAVWPFLLGHYQ 580 Query: 329 WEGTAEEHKAHIRKKTDE-----YFRMKLQW---KSVSPEQERRN 365 + T E RK+ DE Y + +W +++ ++ER + Sbjct: 581 FGMTETE-----RKEVDEQIHACYAQTMAEWLGCEAIVRQRERES 620 >gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sapiens] Length = 1087 Score = 118 bits (295), Expect = 2e-26 Identities = 69/203 (33%), Positives = 110/203 (54%), Gaps = 7/203 (3%) Query: 375 IERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNE 434 IE+DV R DR N +Y P N L L +I+ +Y H ++GYVQGM DLL+P+L ++ +E Sbjct: 878 IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 934 Query: 435 VDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFL-DSQDSGSLCFCF 493 AF CF M+ + NF M + L+++LD L + + + D FC+ Sbjct: 935 ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 993 Query: 494 RWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLH--LLVACAILDMERDTLMLSGFGSNEI 551 RW L+ FKRE + DV +WE +W + H L +A A++++ RD ++ + +I Sbjct: 994 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1053 Query: 552 LKHINELTMKLSVEDVLTRAEAL 574 +K NE+ + + + VL A L Sbjct: 1054 IKFFNEMAERHNTKQVLKLARDL 1076 Score = 37.0 bits (84), Expect = 0.057 Identities = 19/69 (27%), Positives = 33/69 (47%), Gaps = 1/69 (1%) Query: 269 LGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLS 328 + P + G +T W +++ ++ EL I+ GG+ P +R+ W FLLG+ Sbjct: 577 VSPDLPCDAGQGLTARIWEQYLHDSTSYEE-QELLRLIYYGGIQPEIRKAVWPFLLGHYQ 635 Query: 329 WEGTAEEHK 337 + T E K Sbjct: 636 FGMTETERK 644 >gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sapiens] Length = 1148 Score = 118 bits (295), Expect = 2e-26 Identities = 69/203 (33%), Positives = 110/203 (54%), Gaps = 7/203 (3%) Query: 375 IERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNE 434 IE+DV R DR N +Y P N L L +I+ +Y H ++GYVQGM DLL+P+L ++ +E Sbjct: 939 IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 995 Query: 435 VDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFL-DSQDSGSLCFCF 493 AF CF M+ + NF M + L+++LD L + + + D FC+ Sbjct: 996 ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 1054 Query: 494 RWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLH--LLVACAILDMERDTLMLSGFGSNEI 551 RW L+ FKRE + DV +WE +W + H L +A A++++ RD ++ + +I Sbjct: 1055 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1114 Query: 552 LKHINELTMKLSVEDVLTRAEAL 574 +K NE+ + + + VL A L Sbjct: 1115 IKFFNEMAERHNTKQVLKLARDL 1137 Score = 37.7 bits (86), Expect = 0.033 Identities = 26/105 (24%), Positives = 49/105 (46%), Gaps = 14/105 (13%) Query: 269 LGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLS 328 + P + G +T W +++ ++ EL I+ GG+ P +R+ W FLLG+ Sbjct: 577 VSPDLPCDAGQGLTARIWEQYLHDSTSYEE-QELLRLIYYGGIQPEIRKAVWPFLLGHYQ 635 Query: 329 WEGTAEEHKAHIRKKTDE-----YFRMKLQW---KSVSPEQERRN 365 + T E RK+ DE Y + +W +++ ++ER + Sbjct: 636 FGMTETE-----RKEVDEQIHACYAQTMAEWLGCEAIVRQRERES 675 >gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo sapiens] Length = 1006 Score = 115 bits (289), Expect = 1e-25 Identities = 95/356 (26%), Positives = 154/356 (43%), Gaps = 45/356 (12%) Query: 245 AASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPP------VTEEEWARHVGPEGRLQQ 298 + DL PP +PE + P+P E GP V ++ P+ L Sbjct: 659 SVDDLEPPEPQDPE---------DSRPKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGL-- 707 Query: 299 VPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHK------AHIRKKTDEYFRMKL 352 P +N + G+ SL +G+ +G EE AH ++ + + K Sbjct: 708 -PSSRNYSVASGIQSSLDEGQ---SVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKP 763 Query: 353 QWKSVSPEQERRNSLLHGYR-----------SLIERDVSRTDRTNKFYEGPENPGLGLLN 401 Q + +E Y I++DV R DR N +Y P P L L Sbjct: 764 QAGELEAGEELAAVCAAAYTIELLDTVALNLHRIDKDVQRCDR-NYWYFTP--PNLERLR 820 Query: 402 DILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKR 461 D++ +Y H D+GYVQGM DLL+P+L + N+ A+ CF M+ + NF M Sbjct: 821 DVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNG-GAMDT 879 Query: 462 QLGRLLLLLRVLDPLLCDFL-DSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTG- 519 + L+++LD L + + + D FC+RW L+ FKRE + DV +WEV+W Sbjct: 880 HFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAAR 939 Query: 520 -LPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEAL 574 + + L +A A+++ R+ + + +I+K NE +++L A L Sbjct: 940 HISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDL 995 Score = 37.4 bits (85), Expect = 0.043 Identities = 18/89 (20%), Positives = 45/89 (50%), Gaps = 1/89 (1%) Query: 281 VTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHI 340 +T++ W+++ + +++ EL +++ GG+ +R++ W FLLG+ + + +E + Sbjct: 538 LTKDVWSKYQKDKKNYKEL-ELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVD 596 Query: 341 RKKTDEYFRMKLQWKSVSPEQERRNSLLH 369 Y ++ +WK+ +R H Sbjct: 597 AVVAARYQQVLAEWKACEVVVRQREREAH 625 >gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo sapiens] Length = 1051 Score = 115 bits (289), Expect = 1e-25 Identities = 95/356 (26%), Positives = 154/356 (43%), Gaps = 45/356 (12%) Query: 245 AASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPP------VTEEEWARHVGPEGRLQQ 298 + DL PP +PE + P+P E GP V ++ P+ L Sbjct: 704 SVDDLEPPEPQDPE---------DSRPKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGL-- 752 Query: 299 VPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHK------AHIRKKTDEYFRMKL 352 P +N + G+ SL +G+ +G EE AH ++ + + K Sbjct: 753 -PSSRNYSVASGIQSSLDEGQ---SVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKP 808 Query: 353 QWKSVSPEQERRNSLLHGYR-----------SLIERDVSRTDRTNKFYEGPENPGLGLLN 401 Q + +E Y I++DV R DR N +Y P P L L Sbjct: 809 QAGELEAGEELAAVCAAAYTIELLDTVALNLHRIDKDVQRCDR-NYWYFTP--PNLERLR 865 Query: 402 DILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKR 461 D++ +Y H D+GYVQGM DLL+P+L + N+ A+ CF M+ + NF M Sbjct: 866 DVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNG-GAMDT 924 Query: 462 QLGRLLLLLRVLDPLLCDFL-DSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTG- 519 + L+++LD L + + + D FC+RW L+ FKRE + DV +WEV+W Sbjct: 925 HFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAAR 984 Query: 520 -LPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEAL 574 + + L +A A+++ R+ + + +I+K NE +++L A L Sbjct: 985 HISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDL 1040 Score = 37.4 bits (85), Expect = 0.043 Identities = 18/89 (20%), Positives = 45/89 (50%), Gaps = 1/89 (1%) Query: 281 VTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHI 340 +T++ W+++ + +++ EL +++ GG+ +R++ W FLLG+ + + +E + Sbjct: 583 LTKDVWSKYQKDKKNYKEL-ELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVD 641 Query: 341 RKKTDEYFRMKLQWKSVSPEQERRNSLLH 369 Y ++ +WK+ +R H Sbjct: 642 AVVAARYQQVLAEWKACEVVVRQREREAH 670 >gi|40068063 TBC1 domain family, member 22B [Homo sapiens] Length = 505 Score = 76.6 bits (187), Expect = 6e-14 Identities = 63/249 (25%), Positives = 109/249 (43%), Gaps = 33/249 (13%) Query: 310 GLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLH 369 G+ +R W+ L GYL E K +++K +EYF Q+ E+ +++ Sbjct: 210 GVPREVRPITWRLLSGYLP--ANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDT--- 264 Query: 370 GYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILY 429 YR I D+ RT+ ++ P + IL + + H GYVQG++DL++P Sbjct: 265 -YRQ-IHIDIPRTNPLIPLFQQPLVQEI--FERILFIWAIRHPASGYVQGINDLVTPFFV 320 Query: 430 V---------IQN--------------EVDAFWCFCGFMELVQGNFEESQETMKRQLGRL 466 V ++N E D+FWC ++ +Q N+ +Q +++++ L Sbjct: 321 VFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKAL 380 Query: 467 LLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPG-PNL 525 L+ +D + + + L F FRW+ RE P +RLW+ + G + Sbjct: 381 EELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHF 440 Query: 526 HLLVACAIL 534 HL V A L Sbjct: 441 HLYVCAAFL 449 >gi|190014603 TBC1 domain family, member 13 [Homo sapiens] Length = 400 Score = 74.3 bits (181), Expect = 3e-13 Identities = 48/161 (29%), Positives = 78/161 (48%), Gaps = 14/161 (8%) Query: 403 ILLTYCMYHFDLGYVQGMSDLLSPILYVIQN----------EVDAFWCFCGFMELVQGNF 452 IL Y + + YVQGM++++ P+ Y E D F+CF M ++ NF Sbjct: 214 ILFIYAKLNPGIAYVQGMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNLMAEIRDNF 273 Query: 453 ----EESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPD 508 ++SQ + ++ ++ L+ D L L Q+ F FRWL + +EF PD Sbjct: 274 IKSLDDSQCGITYKMEKVYSTLKDKDVELYLKLQEQNIKPQFFAFRWLTLLLSQEFLLPD 333 Query: 509 VLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSN 549 V+R+W+ L+ + LLV CA+L + R+ L+ F N Sbjct: 334 VIRIWDSLFADDNRFDFLLLVCCAMLMLIREQLLEGDFTVN 374 >gi|22507409 TBC1 domain family, member 22A [Homo sapiens] Length = 517 Score = 70.5 bits (171), Expect = 5e-12 Identities = 66/271 (24%), Positives = 107/271 (39%), Gaps = 43/271 (15%) Query: 291 GPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRM 350 GP L+++ R+ G+ +R WK L GYL + A +++K EYF Sbjct: 207 GPNTDLEEL----RRLSWSGIPKPVRPMTWKLLSGYLP--ANVDRRPATLQRKQKEYFAF 260 Query: 351 KLQWKSVSPEQERRNSLLHG--YRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYC 408 + + RN +H YR I D+ R + + IL + Sbjct: 261 ------IEHYYDSRNDEVHQDTYRQ-IHIDIPRMSPEALILQPKVTE---IFERILFIWA 310 Query: 409 MYHFDLGYVQGMSDLLSPILYVI------------------------QNEVDAFWCFCGF 444 + H GYVQG++DL++P V E D +WC Sbjct: 311 IRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKL 370 Query: 445 MELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREF 504 ++ +Q N+ +Q ++ ++ L L+ +D + LD + L F FRW+ RE Sbjct: 371 LDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREV 430 Query: 505 PFPDVLRLWEVLWTGLPG-PNLHLLVACAIL 534 P +RLW+ + G + HL V A L Sbjct: 431 PLRCTIRLWDTYQSEPDGFSHFHLYVCAAFL 461 >gi|34147456 TBC domain-containing protein kinase-like [Homo sapiens] Length = 830 Score = 67.8 bits (164), Expect = 3e-11 Identities = 65/274 (23%), Positives = 110/274 (40%), Gaps = 26/274 (9%) Query: 375 IERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYV-IQN 433 IE D+ R + ++ PE G +L + + H DL Y QG+ L +P LY+ N Sbjct: 442 IEVDIPRCHQYDELLSSPE--GHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNN 499 Query: 434 EVDAFWCFCGFMELVQGNF--EESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCF 491 E A+ C F+ NF +++ ++ L ++ DP L + L+ + Sbjct: 500 EALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLY 559 Query: 492 CFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEI 551 W L F FP + LW+ L G + + AIL RD L+ +GF + Sbjct: 560 AIPWFLTMFTHVFPLHKIFHLWDTLLLG--NSSFPFCIGVAILQQLRDRLLANGFNECIL 617 Query: 552 L-KHINELTMKLSVEDVL-----TRAEALHRQLTACPELPHNVQEILGLAPPAEPHSPSP 605 L + E+ ++ V + + T A +RQ P+ P+ S Sbjct: 618 LFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPK-------------PSSDSSGGR 664 Query: 606 TASPLPLSPTRAPPTPPPSTDTAPQPDSSLEILP 639 +++P + PP S ++ P D E+ P Sbjct: 665 SSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSP 698 >gi|38348348 TBC1 domain family, member 10C [Homo sapiens] Length = 446 Score = 65.9 bits (159), Expect = 1e-10 Identities = 52/206 (25%), Positives = 82/206 (39%), Gaps = 24/206 (11%) Query: 310 GLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLH 369 G+ +LR W L G AH+ +K +L P+ Sbjct: 92 GIPSALRARCWPLLCG------------AHVCQKNSPGTYQELAEAPGDPQ--------- 130 Query: 370 GYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILY 429 + I RD+ R ++ + P+ G L +L Y +Y + GY Q + + +L Sbjct: 131 -WMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLM 189 Query: 430 VIQNEVDAFWCFCGFMEL-VQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGS 488 + E +AFWC E+ + G + E ++ + LLR L P + L G Sbjct: 190 HLPPE-EAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGP 248 Query: 489 LCFCFRWLLIWFKREFPFPDVLRLWE 514 L + W L F R PFP VLR+W+ Sbjct: 249 LLYLPEWFLCLFARSLPFPTVLRVWD 274 >gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] Length = 963 Score = 65.5 bits (158), Expect = 1e-10 Identities = 63/295 (21%), Positives = 115/295 (38%), Gaps = 25/295 (8%) Query: 252 PPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQV--PELKNRIFSG 309 P DDE E + ++L E T +W + + + PELKN I Sbjct: 603 PEDDEEEKLVAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNLI-RA 661 Query: 310 GLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLH 369 G+ R + WK+ + + H + T+ L K++ + Sbjct: 662 GIPHEHRSKVWKWCV---------DRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQ--- 709 Query: 370 GYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILY 429 IE D+ RT NK Y P + G+ L ++LL + + D+GY QG++ L++ L Sbjct: 710 -----IELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALL 764 Query: 430 VIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLL--LLRVLDPLLCDFLDSQDSG 487 ++ E DAFWC +E+ ++ + Q+ + + L+ P L + Sbjct: 765 YLEQE-DAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVD 823 Query: 488 SLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLM 542 F W L+ F + ++W+ GP + A A+ + + ++ Sbjct: 824 YTLITFNWFLVVFVDSVVSDILFKIWDSFL--YEGPKVIFRFALALFKYKEEEIL 876 >gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] Length = 914 Score = 65.5 bits (158), Expect = 1e-10 Identities = 63/295 (21%), Positives = 115/295 (38%), Gaps = 25/295 (8%) Query: 252 PPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQV--PELKNRIFSG 309 P DDE E + ++L E T +W + + + PELKN I Sbjct: 603 PEDDEEEKLVAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNLI-RA 661 Query: 310 GLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLH 369 G+ R + WK+ + + H + T+ L K++ + Sbjct: 662 GIPHEHRSKVWKWCV---------DRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQ--- 709 Query: 370 GYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILY 429 IE D+ RT NK Y P + G+ L ++LL + + D+GY QG++ L++ L Sbjct: 710 -----IELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALL 764 Query: 430 VIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLL--LLRVLDPLLCDFLDSQDSG 487 ++ E DAFWC +E+ ++ + Q+ + + L+ P L + Sbjct: 765 YLEQE-DAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVD 823 Query: 488 SLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLM 542 F W L+ F + ++W+ GP + A A+ + + ++ Sbjct: 824 YTLITFNWFLVVFVDSVVSDILFKIWDSFL--YEGPKVIFRFALALFKYKEEEIL 876 >gi|13994322 TBC1 domain family, member 10A [Homo sapiens] Length = 508 Score = 64.3 bits (155), Expect = 3e-10 Identities = 78/343 (22%), Positives = 133/343 (38%), Gaps = 55/343 (16%) Query: 310 GLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLH 369 G+ PSLR AW++L G K +++ ++ + + SP + Sbjct: 111 GIPPSLRGRAWQYLSG----------GKVKLQQNPGKFDELDM-----SPGDPK------ 149 Query: 370 GYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILY 429 + +IERD+ R ++ + G L +L Y +Y + GY Q + + + +L Sbjct: 150 -WLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLM 208 Query: 430 VIQNEVDAFWCFCGFME-LVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGS 488 + E AFWC E + G + E E ++ L LL+ + P+ L Q Sbjct: 209 HMPAE-QAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDP 267 Query: 489 LCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILD--MERDTLMLSGF 546 L + W + F R P+ VLR+W++ + G + V +L + + + Sbjct: 268 LLYMTEWFMCAFSRTLPWSSVLRVWDMFF--CEGVKIIFRVGLVLLKHALGSPEKVKACQ 325 Query: 547 GSNEILKHINELTMKLSVEDVLTR----AEALHRQL-------------------TACPE 583 G E ++ + L+ K+ E L + RQ+ P Sbjct: 326 GQYETIERLRSLSPKIMQEAFLVQEVVELPVTERQIEREHLIQLRRWQETRGELQCRSPP 385 Query: 584 LPHNVQEILGLAPPAEPH-SPSPTAS-PL--PLSPTRAPPTPP 622 H + IL P P PSP+ PL PL ++A P PP Sbjct: 386 RLHGAKAILDAEPGPRPALQPSPSIRLPLDAPLPGSKAKPKPP 428 >gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] Length = 828 Score = 61.2 bits (147), Expect = 3e-09 Identities = 57/235 (24%), Positives = 96/235 (40%), Gaps = 27/235 (11%) Query: 285 EWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKT 344 +W + + + + + RI+ G + LR E W LL E + Sbjct: 76 KWLKMLKGWEKYKNTEKFHRRIYKG-IPLQLRGEVWALLL----------EIPKMKEETR 124 Query: 345 DEYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDIL 404 D Y ++K + + SP+ + I+ DV+RT R + + L +L Sbjct: 125 DLYSKLKHRARGCSPDIRQ-----------IDLDVNRTFRDHIMFRDRYGVKQQSLFHVL 173 Query: 405 LTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWC----FCGFMELVQGNFEESQETMK 460 Y +Y+ ++GY QGMS ++ +L + NE DAFW F G + G F + + Sbjct: 174 AAYSIYNTEVGYCQGMSQ-ITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLL 232 Query: 461 RQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEV 515 R +L L LDSQ+ + + +W F PF LR+W++ Sbjct: 233 RFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDI 287 >gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] Length = 845 Score = 61.2 bits (147), Expect = 3e-09 Identities = 57/235 (24%), Positives = 96/235 (40%), Gaps = 27/235 (11%) Query: 285 EWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKT 344 +W + + + + + RI+ G + LR E W LL E + Sbjct: 93 KWLKMLKGWEKYKNTEKFHRRIYKG-IPLQLRGEVWALLL----------EIPKMKEETR 141 Query: 345 DEYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDIL 404 D Y ++K + + SP+ + I+ DV+RT R + + L +L Sbjct: 142 DLYSKLKHRARGCSPDIRQ-----------IDLDVNRTFRDHIMFRDRYGVKQQSLFHVL 190 Query: 405 LTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWC----FCGFMELVQGNFEESQETMK 460 Y +Y+ ++GY QGMS ++ +L + NE DAFW F G + G F + + Sbjct: 191 AAYSIYNTEVGYCQGMSQ-ITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLL 249 Query: 461 RQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEV 515 R +L L LDSQ+ + + +W F PF LR+W++ Sbjct: 250 RFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDI 304 >gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] Length = 1069 Score = 60.8 bits (146), Expect = 4e-09 Identities = 77/321 (23%), Positives = 128/321 (39%), Gaps = 55/321 (17%) Query: 240 PQPEGAASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQV 299 PQ +S +P PP+D+ E E P + V++E + + G L Sbjct: 497 PQSGSQSSVIPSPPEDDEE---------EDNDEPLLSGSGDVSKECAEKILETWGELLSK 547 Query: 300 --------PELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMK 351 P+ + + G+ +LR E W+ L G + + E+++ I K+ Sbjct: 548 WHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKE-------- 599 Query: 352 LQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYH 411 SP+ S I RD++RT + +++ G L I Y +Y Sbjct: 600 ------SPQD-----------SAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYD 642 Query: 412 FDLGYVQGMSDLLSPILYVIQNEVDAFWCFC------GFMELVQGNFEESQETMKRQLGR 465 ++GY QG S L+ +L + E AF G EL + NFE+ QL R Sbjct: 643 EEIGYCQGQS-FLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFED-LHCKFYQLER 700 Query: 466 LLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNL 525 L+ + L FLD + + +W L F +FP V + ++L G ++ Sbjct: 701 --LMQEYIPDLYNHFLDISLEAHM-YASQWFLTLFTAKFPLYMVFHIIDLLL--CEGISV 755 Query: 526 HLLVACAILDMERDTLMLSGF 546 VA +L +D L+L+ F Sbjct: 756 IFNVALGLLKTSKDDLLLTDF 776 >gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo sapiens] Length = 815 Score = 54.3 bits (129), Expect = 3e-07 Identities = 67/302 (22%), Positives = 116/302 (38%), Gaps = 41/302 (13%) Query: 252 PPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGP-EGRLQQVPELKNRIFSGG 310 P DDE E E + + G + P W +G L P+ + + G Sbjct: 481 PQDDEAEE--ESDNELSSGTGDVSKDCPEKILYSWGELLGKWHSNLGARPKGLSTLVKSG 538 Query: 311 LSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHG 370 + +LR E W+ L G + + ++ I K + + Sbjct: 539 VPEALRAEVWQLLAGCHDNQAMLDRYRILITKDSAQ------------------------ 574 Query: 371 YRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYV 430 S+I RD+ RT + +++ G L I Y +Y D+GY QG S L+ +L + Sbjct: 575 -ESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQS-FLAAVLLL 632 Query: 431 IQNEVDAFWCFC------GFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQ 484 E AF G +L + NFE+ + + +L L++ P L Sbjct: 633 HMPEEQAFCVLVKIMYDYGLRDLYRNNFED----LHCKFYQLERLMQEQLPDLHSHFSDL 688 Query: 485 DSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLS 544 + + + +W L F +FP V + ++L G N+ VA A+L ++ L+ + Sbjct: 689 NLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLL--CEGLNIIFHVALALLKTSKEDLLQA 746 Query: 545 GF 546 F Sbjct: 747 DF 748 >gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 [Homo sapiens] Length = 1168 Score = 53.9 bits (128), Expect = 4e-07 Identities = 52/220 (23%), Positives = 98/220 (44%), Gaps = 11/220 (5%) Query: 330 EGTAEEHKAHIRKKTDEYFRMKLQWKSVS-----PEQERRNSLLHGYRSLIERDVSRTDR 384 +G H+ I K E F +K Q+ S P +E L +++ D+ RT Sbjct: 799 QGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILI-DLGRTFP 857 Query: 385 TNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWC--FC 442 T+ ++ G L +IL Y + ++GY QG+S ++ IL + +E +AF F Sbjct: 858 THPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLS-FVAGILLLHMSEEEAFKMLKFL 916 Query: 443 GFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKR 502 F ++ + ++ Q+ +L LL L + L+ + G + W L F Sbjct: 917 MFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFAS 976 Query: 503 EFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLM 542 +FP V R++++++ L G + VA ++L + ++ Sbjct: 977 QFPLGFVARVFDMIF--LQGTEVIFKVALSLLGSHKPLIL 1014 >gi|229577000 ecotropic viral integration site 5-like isoform 1 [Homo sapiens] Length = 805 Score = 53.1 bits (126), Expect = 8e-07 Identities = 42/174 (24%), Positives = 80/174 (45%), Gaps = 11/174 (6%) Query: 374 LIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQN 433 LI RD++RT ++F++G ++ G +L +++ Y + ++GY QG + ++ +L + Sbjct: 153 LIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPE 212 Query: 434 EVDAFWCFCGFMELVQGN-----FEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGS 488 E FC F+ L+Q F+ S + + + +L+ P L SQ + Sbjct: 213 EE----AFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHT 268 Query: 489 LCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLM 542 + W L F FP P R++++ G + V A+L + + LM Sbjct: 269 SMYASSWFLTLFLTTFPLPVATRVFDIFM--YEGLEIVFRVGLALLQVNQAELM 320 >gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo sapiens] Length = 794 Score = 53.1 bits (126), Expect = 8e-07 Identities = 42/174 (24%), Positives = 80/174 (45%), Gaps = 11/174 (6%) Query: 374 LIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQN 433 LI RD++RT ++F++G ++ G +L +++ Y + ++GY QG + ++ +L + Sbjct: 153 LIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPE 212 Query: 434 EVDAFWCFCGFMELVQGN-----FEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGS 488 E FC F+ L+Q F+ S + + + +L+ P L SQ + Sbjct: 213 EE----AFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHT 268 Query: 489 LCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLM 542 + W L F FP P R++++ G + V A+L + + LM Sbjct: 269 SMYASSWFLTLFLTTFPLPVATRVFDIFM--YEGLEIVFRVGLALLQVNQAELM 320 >gi|68299759 ecotropic viral integration site 5 [Homo sapiens] Length = 810 Score = 53.1 bits (126), Expect = 8e-07 Identities = 42/176 (23%), Positives = 81/176 (46%), Gaps = 15/176 (8%) Query: 374 LIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQN 433 LI RD++RT + F++ ++ G +L +++ Y + ++GY QG + ++ +L + Sbjct: 201 LIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPE 260 Query: 434 EVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFL-------DSQDS 486 E FC F++L+Q +E K + L L + + ++ + L SQ Sbjct: 261 EE----AFCVFVKLMQD--YRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSF 314 Query: 487 GSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLM 542 + + W L F FP P R++++ + G + V A+L M + LM Sbjct: 315 HTSMYASSWFLTIFLTTFPLPIATRIFDIFMS--EGLEIVFRVGLALLQMNQAELM 368 >gi|167614488 TBC1 domain family, member 10B [Homo sapiens] Length = 808 Score = 53.1 bits (126), Expect = 8e-07 Identities = 51/201 (25%), Positives = 83/201 (41%), Gaps = 12/201 (5%) Query: 374 LIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQN 433 +IE+D+ R ++ + G L IL Y +Y D GY Q + + + +L + Sbjct: 402 VIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPA 461 Query: 434 EVDAFWCFCGFME-LVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFC 492 E AFWC + + G + E ++ LLR PL L Q + + Sbjct: 462 E-QAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYM 520 Query: 493 FRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTL-----MLSGFG 547 W + F R P+ VLR+W++ + G + VA +L R TL + S G Sbjct: 521 TEWFMCIFARTLPWASVLRVWDMFF--CEGVKIIFRVALVLL---RHTLGSVEKLRSCQG 575 Query: 548 SNEILKHINELTMKLSVEDVL 568 E ++ + L + ED L Sbjct: 576 MYETMEQLRNLPQQCMQEDFL 596 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.137 0.425 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 30,948,821 Number of Sequences: 37866 Number of extensions: 1815526 Number of successful extensions: 20834 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 224 Number of HSP's successfully gapped in prelim test: 454 Number of HSP's that attempted gapping in prelim test: 14005 Number of HSP's gapped (non-prelim): 5785 length of query: 648 length of database: 18,247,518 effective HSP length: 109 effective length of query: 539 effective length of database: 14,120,124 effective search space: 7610746836 effective search space used: 7610746836 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.