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Search of human proteins with 13375646
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13375646 leucine rich repeat and fibronectin type III domain
containing 3 [Homo sapiens]
(628 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13375646 leucine rich repeat and fibronectin type III domain ... 1273 0.0
gi|149773484 leucine rich repeat and fibronectin type III domain... 643 0.0
gi|55741571 leucine rich repeat and fibronectin type III domain ... 607 e-173
gi|27363458 leucine rich repeat and fibronectin type III domain ... 593 e-169
gi|31542244 leucine rich repeat and fibronectin type III domain ... 592 e-169
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 150 3e-36
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 145 8e-35
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 136 7e-32
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 135 9e-32
gi|126517478 peroxidasin homolog-like [Homo sapiens] 134 3e-31
gi|51317373 netrin-G1 ligand [Homo sapiens] 132 7e-31
gi|229089140 leucine rich repeat containing 24 [Homo sapiens] 131 2e-30
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 129 8e-30
gi|109150416 peroxidasin [Homo sapiens] 127 4e-29
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 124 2e-28
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 124 2e-28
gi|194306623 immunoglobulin superfamily containing leucine-rich ... 123 6e-28
gi|194306621 immunoglobulin superfamily containing leucine-rich ... 123 6e-28
gi|39930401 immunoglobulin superfamily containing leucine-rich r... 123 6e-28
gi|194306618 immunoglobulin superfamily containing leucine-rich ... 123 6e-28
gi|193083136 leucine-rich repeat, immunoglobulin-like and transm... 117 3e-26
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 108 1e-23
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 108 1e-23
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 108 1e-23
gi|41582239 immunoglobulin superfamily containing leucine-rich r... 107 3e-23
gi|5031809 immunoglobulin superfamily containing leucine-rich re... 107 3e-23
gi|188528675 slit homolog 1 [Homo sapiens] 106 6e-23
gi|14149694 retina specific protein PAL [Homo sapiens] 106 7e-23
gi|11321571 slit homolog 3 [Homo sapiens] 102 1e-21
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 101 2e-21
>gi|13375646 leucine rich repeat and fibronectin type III domain
containing 3 [Homo sapiens]
Length = 628
Score = 1273 bits (3294), Expect = 0.0
Identities = 628/628 (100%), Positives = 628/628 (100%)
Query: 1 MAILPLLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRR 60
MAILPLLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRR
Sbjct: 1 MAILPLLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRR 60
Query: 61 AAELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLT 120
AAELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLT
Sbjct: 61 AAELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLT 120
Query: 121 SLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLG 180
SLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLG
Sbjct: 121 SLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLG 180
Query: 181 NVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPAS 240
NVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPAS
Sbjct: 181 NVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPAS 240
Query: 241 ALVLAFGGNPLHCNCELVWLRRLAREDDLEACASPPALGGRYFWAVGEEEFVCEPPVVTH 300
ALVLAFGGNPLHCNCELVWLRRLAREDDLEACASPPALGGRYFWAVGEEEFVCEPPVVTH
Sbjct: 241 ALVLAFGGNPLHCNCELVWLRRLAREDDLEACASPPALGGRYFWAVGEEEFVCEPPVVTH 300
Query: 301 RSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGTLELLVTEPGD 360
RSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGTLELLVTEPGD
Sbjct: 301 RSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGTLELLVTEPGD 360
Query: 361 GGIFTCIAANAAGEATAAVELTVGPPPPPQLANSTSCDPPRDGDPDALTPPSAASASAKV 420
GGIFTCIAANAAGEATAAVELTVGPPPPPQLANSTSCDPPRDGDPDALTPPSAASASAKV
Sbjct: 361 GGIFTCIAANAAGEATAAVELTVGPPPPPQLANSTSCDPPRDGDPDALTPPSAASASAKV 420
Query: 421 ADTGPPTDRGVQVTEHGATAALVQWPDQRPIPGIRMYQIQYNSSADDILVYRMIPAESRS 480
ADTGPPTDRGVQVTEHGATAALVQWPDQRPIPGIRMYQIQYNSSADDILVYRMIPAESRS
Sbjct: 421 ADTGPPTDRGVQVTEHGATAALVQWPDQRPIPGIRMYQIQYNSSADDILVYRMIPAESRS 480
Query: 481 FLLTDLASGRTYDLCVLAVYEDSATGLTATRPVGCARFSTEPALRPCGAPHAPFLGGTMI 540
FLLTDLASGRTYDLCVLAVYEDSATGLTATRPVGCARFSTEPALRPCGAPHAPFLGGTMI
Sbjct: 481 FLLTDLASGRTYDLCVLAVYEDSATGLTATRPVGCARFSTEPALRPCGAPHAPFLGGTMI 540
Query: 541 IALGGVIVASVLVFIFVLLMRYKVHGGQPPGKAKIPAPVSSVCSQTNGALGPTPTPAPPA 600
IALGGVIVASVLVFIFVLLMRYKVHGGQPPGKAKIPAPVSSVCSQTNGALGPTPTPAPPA
Sbjct: 541 IALGGVIVASVLVFIFVLLMRYKVHGGQPPGKAKIPAPVSSVCSQTNGALGPTPTPAPPA 600
Query: 601 PEPAALRAHTVVQLDCEPWGPGHEPVGP 628
PEPAALRAHTVVQLDCEPWGPGHEPVGP
Sbjct: 601 PEPAALRAHTVVQLDCEPWGPGHEPVGP 628
>gi|149773484 leucine rich repeat and fibronectin type III domain
containing 1 [Homo sapiens]
Length = 771
Score = 643 bits (1659), Expect = 0.0
Identities = 349/609 (57%), Positives = 421/609 (69%), Gaps = 41/609 (6%)
Query: 18 SPPQSATP------------SPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELR 65
SPP +A P PCP RC CQ + L++LC GLLFVPP++DRR ELR
Sbjct: 12 SPPPAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELR 71
Query: 66 LADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEG 125
L DNFIA+VRRRD ANMT L+HL+LSRNTI VAAGAFADLRALRALHLD NRL +
Sbjct: 72 LTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGD 131
Query: 126 QLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTL 185
QLRGL NLRHLIL NNQ+ + + A D T+EDLDLSYNNLE LPWEA+G++ N+NTL
Sbjct: 132 QLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTL 191
Query: 186 GLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRG-SPASALVL 244
LDHNL+ + G F +LHKL RLDMTSNRL +PPD LF R ++ G P + L +
Sbjct: 192 TLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLR----SQGTGPKPPTPLTV 247
Query: 245 AFGGNPLHCNCELVWLRRLAREDDLEACASPPALGGRYFWAVGEEEFVCEPPVVTHRSPP 304
+FGGNPLHCNCEL+WLRRL REDDLE CA+P L RYFW++ EEEF+CEPP++T ++
Sbjct: 248 SFGGNPLHCNCELLWLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGG 307
Query: 305 LA-VPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGTLELLVTEPGDGGI 363
A V G+ +LRCRAVGDPEP V WV+P GRLLGNSSR R +GTL++ +T D G
Sbjct: 308 RALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTLRDSGT 367
Query: 364 FTCIAANAAGEATAAVELTVGPPP---PPQLANSTSCDPPRDGDPDALTP--PSAASASA 418
FTCIA+NAAGEATA VE+ V P P PP A +P G D TP P A ++A
Sbjct: 368 FTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEP---GSSDIATPGRPGANDSAA 424
Query: 419 KVADTGPPTDRGVQVTEHGATAALVQWPDQRPIPGIRMYQIQYNSSADDILVYRMIPAES 478
+R + E + + L++WP QRP+PGIRMYQ+QYNSS DD LVYRMIP+ S
Sbjct: 425 ---------ERRLVAAELTSNSVLIRWPAQRPVPGIRMYQVQYNSSVDDSLVYRMIPSTS 475
Query: 479 RSFLLTDLASGRTYDLCVLAVYEDSATGLTATRPVGCARFSTEPALRPCGAPHAPFLGGT 538
++FL+ DLA+GR YDLCVLAVY+D AT L ATR VGC +F+T PC A FLGGT
Sbjct: 476 QTFLVNDLAAGRAYDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGT 535
Query: 539 MIIALGGVIVASVLVFIFVLLMRYKVHGG----QPPGKAKIPAPVSSVCSQTNGA-LGPT 593
MIIA+GGVIVASVLVFI +L++RYKV+G + G +P VS VCSQTNGA G
Sbjct: 536 MIIAIGGVIVASVLVFIVLLMIRYKVYGDGDSRRVKGSRSLPR-VSHVCSQTNGAGTGAA 594
Query: 594 PTPAPPAPE 602
PA PA +
Sbjct: 595 QAPALPAQD 603
>gi|55741571 leucine rich repeat and fibronectin type III domain
containing 2 [Homo sapiens]
Length = 789
Score = 607 bits (1564), Expect = e-173
Identities = 310/585 (52%), Positives = 398/585 (68%), Gaps = 8/585 (1%)
Query: 23 ATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIASVRRRDLANM 82
A CP+ C CQ S L LCP GLLFVPP +DRR ELRL NFI + R+D ANM
Sbjct: 16 AVVDACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANM 75
Query: 83 TGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQ 142
TGL+ L+LSRNTI H+ +F DL +LR+LHLD NRL SLGE LRGLVNL+HLI++NNQ
Sbjct: 76 TGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQ 135
Query: 143 LAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSR 202
L +A A +D TLEDLDLSYNNL LPW+++ R+ N++ L LDHNLL + G F+
Sbjct: 136 LGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFAD 195
Query: 203 LHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRR 262
L KLARLD+TSNRL +PPDP+F+R A A L +FGGNPLHCNCEL+WLRR
Sbjct: 196 LQKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFGGNPLHCNCELLWLRR 255
Query: 263 LAREDDLEACASPPALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAVGD 322
L R+DDLE C SP L GRYFW V EEEFVCEPP++T + L V G+ A L+C+A+GD
Sbjct: 256 LERDDDLETCGSPGGLKGRYFWHVREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGD 315
Query: 323 PEPRVRWVSPQGRLLGNSSRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELT 382
P P + WV+P RL+GNSSR + NGTL++ +T D G FTCIAANAAGEATA VE++
Sbjct: 316 PSPLIHWVAPDDRLVGNSSRTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVS 375
Query: 383 VGPPPPPQLANSTSCDPPRDGDPDALTPPSAASASAKVADTG----PPTDRGVQVTEHGA 438
+ P L+NSTS P +T S S + G P +R V V+E
Sbjct: 376 I--VQLPHLSNSTSRTAPPKSRLSDITGSSKTSRGGGGSGGGEPPKSPPERAVLVSEVTT 433
Query: 439 TAALVQWPDQRPIPGIRMYQIQYNSSADDILVYRMIPAESRSFLLTDLASGRTYDLCVLA 498
T+ALV+W + P ++MYQ+QYN S D++L+YRMIPA +++F++ +L SG YDLCVLA
Sbjct: 434 TSALVKWSVSKSAPRVKMYQLQYNCSDDEVLIYRMIPASNKAFVVNNLVSGTGYDLCVLA 493
Query: 499 VYEDSATGLTATRPVGCARFSTEPALRPCGAPHAPFLGGTMIIALGGVIVASVLVFIFVL 558
+++D+AT LTAT VGCA+F T+ C + H+ LGGTMI+ +GG+IVA++LVFI +L
Sbjct: 494 MWDDTATTLTATNIVGCAQFFTKADYPQCQSMHSQILGGTMILVIGGIIVATLLVFIVIL 553
Query: 559 LMRYKVHGGQPPGKAKIPAPVSSVCSQTNGALGPTPTPAPPAPEP 603
++RYKV + P +K+ A VS+V SQTNGA P P+ AP P
Sbjct: 554 MVRYKVCNHEAP--SKMAAAVSNVYSQTNGAQPPPPSSAPAGAPP 596
>gi|27363458 leucine rich repeat and fibronectin type III domain
containing 4 [Homo sapiens]
Length = 635
Score = 593 bits (1530), Expect = e-169
Identities = 327/603 (54%), Positives = 396/603 (65%), Gaps = 33/603 (5%)
Query: 5 PLLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAEL 64
PLLL LL A+ CP C CQ S LS LC GLLFVPP++DRR EL
Sbjct: 4 PLLLLLLASGAAA----------CPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVEL 53
Query: 65 RLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGE 124
RLADNFI ++ D NMTGL+ L+LSRN I + A AF DL +LR+LHLDGNRL LG
Sbjct: 54 RLADNFIQALGPPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGT 113
Query: 125 GQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNT 184
G LRG VNL+HLILS NQL +A GA DD E+LEDLDLSYNNL Q+PW +G + ++T
Sbjct: 114 GSLRGPVNLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHT 173
Query: 185 LGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVL 244
L LDHNL+ ++P GAF++L +L+RLD+TSNRL T+ PDPLFSR R + + LVL
Sbjct: 174 LNLDHNLIDALPPGAFAQLGQLSRLDLTSNRLATLAPDPLFSR----GRDAEASPAPLVL 229
Query: 245 AFGGNPLHCNCELVWLRRLAREDDLEACASPPALGGRYFWAVGEEEFVCEPPVVTHRSPP 304
+F GNPLHCNCEL+WLRRLAR DDLE CASPP L GRYFWAV E EF CEPP++ +
Sbjct: 230 SFSGNPLHCNCELLWLRRLARPDDLETCASPPGLAGRYFWAVPEGEFSCEPPLIARHTQR 289
Query: 305 LAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGTLELLVTEPGDGGIF 364
L V G+ A LRCRA+GDP P + WV P RL+GNSSRARAFPNGTLE+ VT GD G +
Sbjct: 290 LWVLEGQRATLRCRALGDPAPTMHWVGPDDRLVGNSSRARAFPNGTLEIGVTGAGDAGGY 349
Query: 365 TCIAANAAGEATAAVELTVGPPPPPQLANSTSCDPPRDGDPDALTPPSAASASAKVADTG 424
TCIA N AGEATA VEL V P ++S + R G PS +ASA+ A G
Sbjct: 350 TCIATNPAGEATARVELRVLALPH---GGNSSAEGGRPG-------PSDIAASARTAAEG 399
Query: 425 PPT---DRGVQVTEHGATAALVQWPDQRPIPGIRMYQIQYNSSADDILVYRMIPAESRSF 481
T + VQVTE AT+ LV W RP + M+QIQYNSS D+ L+YR++PA S F
Sbjct: 400 EGTLESEPAVQVTEVTATSGLVSWGPGRPADPVWMFQIQYNSSEDETLIYRIVPASSHHF 459
Query: 482 LLTDLASGRTYDLCVLAVYEDSA-TGLTATRPVGCARFSTEPALRPCGAPHAPFLGGTMI 540
LL L G YDLC+LA+ + + LTATR +GCA FST PA C A A LGGT+
Sbjct: 460 LLKHLVPGADYDLCLLALSPAAGPSDLTATRLLGCAHFSTLPASPLCHALQAHVLGGTLT 519
Query: 541 IALGGVIVASVLVFIFVLLMRYKVHGGQPPGKAKIPAPVSSVCSQTNGALGPTPTPAPPA 600
+A+GGV+VA++LVF LL+R G+ G ++P +S V SQTNG PTP PP
Sbjct: 520 VAVGGVLVAALLVFTVALLVR-----GRGAGNGRLPLKLSHVQSQTNGGPSPTPKAHPPR 574
Query: 601 PEP 603
P
Sbjct: 575 SPP 577
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 592 bits (1525), Expect = e-169
Identities = 304/564 (53%), Positives = 398/564 (70%), Gaps = 9/564 (1%)
Query: 28 CPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIASVRRRDLANMTGLLH 87
CP+RC CQ S L+ LC GLLFVPP++DRR ELRLADNF+ +++R+D ANMT L+
Sbjct: 20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVD 79
Query: 88 LSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALA 147
L+LSRNTI + AFADLR LRALHL+ NRLT + GL NL HLIL+NNQL ++
Sbjct: 80 LTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLIS 139
Query: 148 AGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLA 207
+ A DD LE+LDLSYNNLE +PW+A+ ++ +++TL LDHN++ ++P G FS LHK+
Sbjct: 140 STAFDDVF-ALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMT 198
Query: 208 RLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLARED 267
RLD+TSN+L +PPDPLF R +LA S L+FGGNPLHCNCEL+WLRRL+RED
Sbjct: 199 RLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSRED 258
Query: 268 DLEACASPPALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAVGDPEPRV 327
DLE CASPP L GRYFW++ EEEF+CEPP++T + + V G+ A LRC+A GDPEP +
Sbjct: 259 DLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAI 318
Query: 328 RWVSPQGRLLGNSSRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPP 387
W+SP+G+L+ N++R+ + NGTL++L+T D G FTCIA+N AGEAT V+L +
Sbjct: 319 HWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHI--IK 376
Query: 388 PPQLANSTS-CDPPRDGDPDALT-PPSAASASAKVADTGPPTDRGVQVTEHGATAALVQW 445
P L NST+ P G D T S ++ S+ DT D+ + V E ++ AL+++
Sbjct: 377 LPHLLNSTNHIHEPDPGSSDISTSTKSGSNTSSSNGDTKLSQDK-IVVAEATSSTALLKF 435
Query: 446 PDQRPIPGIRMYQIQYNSSADDILVYRMIPAESRSFLLTDLASGRTYDLCVLAVYEDSAT 505
QR IPGIRM+QIQYN + DD LVYRMIP S++FL+ +LA+G YDLCVLA+Y+D T
Sbjct: 436 NFQRNIPGIRMFQIQYNGTYDDTLVYRMIPPTSKTFLVNNLAAGTMYDLCVLAIYDDGIT 495
Query: 506 GLTATRPVGCARFSTEPALRPCGAPHAPFLGGTMIIALGGVIVASVLVFIFVLLMRYKVH 565
LTATR VGC +F+TE C + FLGGTMII +GG+IVASVLVFI +L++RYKV
Sbjct: 496 SLTATRVVGCIQFTTEQDYVRCHFMQSQFLGGTMIIIIGGIIVASVLVFIIILMIRYKVC 555
Query: 566 GGQPPGKAKIPAPVSSVCSQTNGA 589
G+ K+ VS+V SQTNGA
Sbjct: 556 NNN--GQHKV-TKVSNVYSQTNGA 576
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 150 bits (380), Expect = 3e-36
Identities = 113/349 (32%), Positives = 161/349 (46%), Gaps = 27/349 (7%)
Query: 64 LRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLG 123
L + DN + V RR A + L L+L R + ++ + LR+L AL L + SL
Sbjct: 155 LEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLE 214
Query: 124 EGQLRGLVNLRHLILSN-NQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNV 182
+ R L L HL + N L +AAG+L L L +++ N+ +P AL ++
Sbjct: 215 DQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGL--NLTSLSVTHTNITAVPAAALRHQAHL 272
Query: 183 NTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFS-RLPLLARPRGSPASA 241
L L HN +++VP G+F L +L L + L + P R L + S
Sbjct: 273 TCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLST 332
Query: 242 L------------VLAFGGNPLHCNCELVWL----RRLAREDDLEACASPPALGGRYFWA 285
L L GNPL C+C L+W+ + L + L ACA+P + G
Sbjct: 333 LEESTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLPACATPAEVRGDALRN 392
Query: 286 VGE----EEFVCEPPVVTHRS-PPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNS 340
+ + E FVC P + R + AG CRA G+P P V WV+PQ R + +
Sbjct: 393 LPDSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTAT 452
Query: 341 S--RARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPP 387
S RAR P GTLE+ P D G +TC+A+NA G T LTV P P
Sbjct: 453 SAGRARVLPGGTLEIQDARPQDSGTYTCVASNAGGNDTYFATLTVRPEP 501
Score = 95.1 bits (235), Expect = 2e-19
Identities = 80/234 (34%), Positives = 100/234 (42%), Gaps = 32/234 (13%)
Query: 1 MAILPLLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRR 60
+ +L L L LLP AP PP CP RC C Q+ +V C L VP +
Sbjct: 5 LCVLSLPLLLLPAAP---PPAGG----CPARCECTVQTR--AVACTRRRLTAVPDGIPAE 55
Query: 61 AAELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLT 120
L L+ N I + DLA + L L LS N I HV GAFA+L LR L L GN+L
Sbjct: 56 TRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLK 115
Query: 121 SLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAE-----------------------T 157
+ G L NL L LS N+L L D
Sbjct: 116 LIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLA 175
Query: 158 LEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDM 211
LE+L L NL L E+LG L ++ L L H +AS+ F RL L L++
Sbjct: 176 LEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEI 229
Score = 48.9 bits (115), Expect = 1e-05
Identities = 37/110 (33%), Positives = 53/110 (48%), Gaps = 4/110 (3%)
Query: 110 RALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLE 169
RA+ RLT++ +G R L LS N++ L G L LE+LDLS N +
Sbjct: 36 RAVACTRRRLTAVPDGIP---AETRLLELSRNRIRCLNPGDLA-ALPALEELDLSENAIA 91
Query: 170 QLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTI 219
+ A L + L L N L +P G F+RL L LD++ N+L +
Sbjct: 92 HVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVIL 141
Score = 38.5 bits (88), Expect = 0.019
Identities = 26/68 (38%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 161 LDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIP 220
L+LS N + L L L + L L N +A V GAF+ L +L L + N+L IP
Sbjct: 59 LELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIP 118
Query: 221 PDPLFSRL 228
P +F+RL
Sbjct: 119 PG-VFTRL 125
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 145 bits (367), Expect = 8e-35
Identities = 123/430 (28%), Positives = 179/430 (41%), Gaps = 73/430 (16%)
Query: 14 APASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIAS 73
A SPP ++ CP C C Q+ V+C L VP S+ L L +N I
Sbjct: 47 AGGGSPPATS----CPVACSCSNQAS--RVICTRRDLAEVPASIPVNTRYLNLQENGIQV 100
Query: 74 VRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNL 133
+R ++ L L LS+N +R + GAF L +L L L NRLT++ L L
Sbjct: 101 IRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKL 160
Query: 134 RHLILSNNQLAALAAGALD--------DCAET---------------------------- 157
R L L NN + ++ + A + D E
Sbjct: 161 RELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLK 220
Query: 158 ----------LEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLA 207
LE+L+LS N L+ + + L ++ L L H +A++ AF L L
Sbjct: 221 DIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLE 280
Query: 208 RLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLARE- 266
L+++ N L ++P D LF+ L L R + NP HCNC+++WL +E
Sbjct: 281 ELNLSHNNLMSLPHD-LFTPLHRLER----------VHLNHNPWHCNCDVLWLSWWLKET 329
Query: 267 --DDLEACA---SPPALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAVG 321
+ CA +P L GRY + + F C PV+ L V G A L+CR G
Sbjct: 330 VPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCR-TG 388
Query: 322 DPEPRVRWVSPQGRLLGNSS---RARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAA 378
V W++P G L+ + S R +GTL D G +TC+ N+AG TA+
Sbjct: 389 TSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTAS 448
Query: 379 VELTVGPPPP 388
L V P
Sbjct: 449 ATLNVSAVDP 458
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 136 bits (342), Expect = 7e-32
Identities = 113/362 (31%), Positives = 156/362 (43%), Gaps = 32/362 (8%)
Query: 63 ELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSL 122
+L + DN + V A + L L+L R + V A A L AL AL L + L
Sbjct: 160 KLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRL 219
Query: 123 GEGQLRGLVNLRHLILSN-NQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGN 181
G LRGL L+ L + L AL G+L L L ++ NL +P++AL L
Sbjct: 220 PAGALRGLGQLKELEIHLWPSLEALDPGSL--VGLNLSSLAITRCNLSSVPFQALYHLSF 277
Query: 182 VNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPP---------------DPLFS 226
+ L L N ++++PA S L +L L ++ LT+I D
Sbjct: 278 LRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQ 337
Query: 227 RLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLAREDDL----EACASPPALGGRY 282
L A P SP + L GNPL C+C L+WL RL R D ACA P + G+
Sbjct: 338 TLEETAFP--SPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQGKS 395
Query: 283 FWAVGE----EEFVCEPPVVTHRSPPLAVPA-GRPAALRCRAVGDPEPRVRWVSPQGRLL 337
+ F C+P ++ P + G A C GDP P V W+ P G L
Sbjct: 396 LKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWL 455
Query: 338 GNSSRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPPPPQLANSTSC 397
G + R R +GTLE+ + D G + C+ +N AG + L V PP N T
Sbjct: 456 GRAGRVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPP---NGTLS 512
Query: 398 DP 399
DP
Sbjct: 513 DP 514
Score = 79.7 bits (195), Expect = 7e-15
Identities = 69/219 (31%), Positives = 101/219 (46%), Gaps = 12/219 (5%)
Query: 6 LLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELR 65
L L LLP S CP C C +Q P +VLC L VP L L
Sbjct: 18 LFLLLLPGGSGGS---------CPAVCDCTSQ--PQAVLCGHRQLEAVPGGLPLDTELLD 66
Query: 66 LADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEG 125
L+ N + +++ L+ ++ L L LS N + + GAF L++L L L GNRL +G G
Sbjct: 67 LSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPG 126
Query: 126 QLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTL 185
GL L L L NQ+ GA + +L+ L++ N+L + A L ++TL
Sbjct: 127 VFSGLSALTLLDLRLNQIVLFLDGAFGELG-SLQKLEVGDNHLVFVAPGAFAGLAKLSTL 185
Query: 186 GLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPL 224
L+ L++VP A +RL L L + + +P L
Sbjct: 186 TLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGAL 224
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 135 bits (341), Expect = 9e-32
Identities = 116/432 (26%), Positives = 178/432 (41%), Gaps = 75/432 (17%)
Query: 7 LLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRL 66
+LC A AS+ PQ+ CP C C Q V+C GL VP + L L
Sbjct: 30 ILCAAIAAAASAGPQN-----CPSVCSCSNQFS--KVVCTRRGLSEVPQGIPSNTRYLNL 82
Query: 67 ADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQ 126
+N I ++ ++ L L L RN+IR + GAF L +L L L N LT + G
Sbjct: 83 MENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGA 142
Query: 127 LRGLVNLRHLILSNNQLAALAAGALD--------DCAET--------------------- 157
L LR L L NN + ++ + A + D E
Sbjct: 143 FEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLN 202
Query: 158 -----------------LEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAF 200
LE+L++S N+ ++ + L ++ L + ++ ++ + AF
Sbjct: 203 LGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAF 262
Query: 201 SRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWL 260
L L L++ N L+++P D LF+ L L L NP +C+C+++WL
Sbjct: 263 DGLASLVELNLAHNNLSSLPHD-LFTPLRYLVE----------LHLHHNPWNCDCDILWL 311
Query: 261 RRLARE------DDLEACASPPALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAA 314
RE C +P + GRY V + F C P + L + GR A
Sbjct: 312 AWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAE 371
Query: 315 LRCRAVGDPEPRVRWVSPQGRLLGNSS---RARAFPNGTLELLVTEPGDGGIFTCIAANA 371
L+CR P V+W+ P G +L ++S R +GTL D G++TC+ N
Sbjct: 372 LKCRT--PPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNV 429
Query: 372 AGEATAAVELTV 383
AG + A+ L V
Sbjct: 430 AGNSNASAYLNV 441
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 134 bits (336), Expect = 3e-31
Identities = 94/296 (31%), Positives = 133/296 (44%), Gaps = 44/296 (14%)
Query: 88 LSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALA 147
L L N IR + AF L+ L L L+ N + + GL NL +L L N++ AL
Sbjct: 55 LDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALD 114
Query: 148 AGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLA 207
+LE L + +N LE L E G L + L L +N L+ +PAG+FS L L
Sbjct: 115 KQTFKGLI-SLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLK 173
Query: 208 RLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRL---- 263
RL + SN L C+C+L+WL L
Sbjct: 174 RLRLDSNALV-----------------------------------CDCDLMWLGELLQGF 198
Query: 264 AREDDLEA---CASPPALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAV 320
A+ +A C P L GR +V EEF C+ P +T + VP+G CRA
Sbjct: 199 AQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAE 258
Query: 321 GDPEPRVRWVSPQGRL-LGNSSRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEA 375
G+P+P + W+ L L + +R F +GTL + T D G++ C+A N+AGEA
Sbjct: 259 GNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEA 314
Score = 85.5 bits (210), Expect = 1e-16
Identities = 106/412 (25%), Positives = 153/412 (37%), Gaps = 66/412 (16%)
Query: 27 PCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIASVRRRDLANMTGLL 86
PCP RC C ++ L +L P + ++ L L N I + + L
Sbjct: 23 PCPSRCLCFKSTVRCMHL-----MLDHIPQVPQQTTVLDLRFNRIREIPGSAFKKLKNLN 77
Query: 87 HLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAAL 146
L L+ N IR ++ AF L L L+L N + +L + +GL++L HL + NQL L
Sbjct: 78 TLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEML 137
Query: 147 AAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLL-------------- 192
D LE L L N L ++P + L ++ L LD N L
Sbjct: 138 QPETFGDLLR-LERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQ 196
Query: 193 ---------ASVPAGAFSRLHKLARLDMT-------SNRLTTIPPD---PLFSRLPLLAR 233
A+ RLH A +T S R+T P D P + + R
Sbjct: 197 GFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCR 256
Query: 234 PRGSPASALVLAFGGNPLHCNCEL--------VWLRRLAREDD--LEACASPPALGG--- 280
G+P ++ + L + + R RE D + C + + G
Sbjct: 257 AEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKT 316
Query: 281 -----RYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGR 335
RY + FV +P V G L C A G P P + W G
Sbjct: 317 QSAMLRYSSLPAKPSFVIQPQ-------DTEVLIGTSTTLECMATGHPHPLITWTRDNGL 369
Query: 336 LLGNSSRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPP 387
L + SR A +G +T+ D G FTC A N+ G AA + V PP
Sbjct: 370 EL-DGSRHVATSSGLYLQNITQR-DHGRFTCHANNSHGTVQAAANIIVQAPP 419
Score = 41.2 bits (95), Expect = 0.003
Identities = 25/87 (28%), Positives = 40/87 (45%), Gaps = 1/87 (1%)
Query: 297 VVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGTLELLVT 356
V T +V G+ + C A G+P+P + W + +G + S + GTL +
Sbjct: 512 VFTQLPQDTSVEVGKNINISCHAQGEPQPIITW-NKEGVQITESGKFHVDDEGTLTIYDA 570
Query: 357 EPGDGGIFTCIAANAAGEATAAVELTV 383
D G + C+A N+ G A + LTV
Sbjct: 571 GFPDQGRYECVARNSFGLAVTNMFLTV 597
Score = 35.8 bits (81), Expect = 0.12
Identities = 21/69 (30%), Positives = 31/69 (44%), Gaps = 1/69 (1%)
Query: 317 CRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEAT 376
C A G+P P + W G+L +GTL + D G + C A ++ G
Sbjct: 440 CEADGNPPPVIVWTKTGGQLPVEGQHT-VLSSGTLRIDRAAQHDQGQYECQAVSSLGVKK 498
Query: 377 AAVELTVGP 385
+V+LTV P
Sbjct: 499 VSVQLTVKP 507
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 132 bits (333), Expect = 7e-31
Identities = 111/411 (27%), Positives = 170/411 (41%), Gaps = 69/411 (16%)
Query: 28 CPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIASVRRRDLANMTGLLH 87
CP C C Q V+C L VP + L L +N I ++ ++ L
Sbjct: 47 CPSVCSCSNQFS--KVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEI 104
Query: 88 LSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNN------ 141
L LSRN IR + GAF L L L L NRLT++ G L L+ L L NN
Sbjct: 105 LQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIP 164
Query: 142 -------------------QLAALAAGALDDCAET---------------------LEDL 161
+L+ ++ GA + + L++L
Sbjct: 165 SYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDEL 224
Query: 162 DLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPP 221
DLS N+L + + L ++ L + + + + AF L L +++ N LT +P
Sbjct: 225 DLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPH 284
Query: 222 DPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLARE---DDLEACA---SP 275
D LF+ L L R + NP +CNC+++WL ++ + CA +P
Sbjct: 285 D-LFTPLHHLER----------IHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTP 333
Query: 276 PALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGR 335
P L GRY + + F C PV+ L V G A L+CRA V W++P G
Sbjct: 334 PNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRA-STSLTSVSWITPNGT 392
Query: 336 LLGNSS---RARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTV 383
++ + + R +GTL D G++TC+ +N+ G TA+ L V
Sbjct: 393 VMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNV 443
>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
Length = 513
Score = 131 bits (330), Expect = 2e-30
Identities = 140/467 (29%), Positives = 181/467 (38%), Gaps = 87/467 (18%)
Query: 2 AILPLLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRA 61
A+LPLLL LLPL A CP CRC + + V C L VP +
Sbjct: 7 ALLPLLLLLLPLRAAG----------CPAACRCYSAT----VECGALRLRVVPLGIPPGT 52
Query: 62 AELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTS 121
L L DN IA + LA + L L L N++R + AGAF L L L NRL
Sbjct: 53 QTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRG 112
Query: 122 LGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGN 181
L G GL LR L L+ NQLA L LD ++ +L +L
Sbjct: 113 LRSGAFVGLAQLRVLYLAGNQLARL--------------LDFTFLHLPRL---------- 148
Query: 182 VNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASA 241
L L N + + A + L LA LD++ N+L TI + L PL AS
Sbjct: 149 -QELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREAL---QPL--------ASL 196
Query: 242 LVLAFGGNPLHCNCELVWL---------RRLAREDDLEACASPPALGGRYFWAVGEEEFV 292
VL NP C+C L WL R L D CA PP L + V +
Sbjct: 197 QVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLI 256
Query: 293 CEPPVVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRW--------------VSPQGRLLG 338
C PP V + L G + C+A G P+P V W +G LLG
Sbjct: 257 CIPPSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLG 316
Query: 339 -NSSRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPPPPQLANSTSC 397
A +G L L G + C A+NA G A L L N++
Sbjct: 317 LGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRL---------LVNASRQ 367
Query: 398 DPPRDGDPDALTPPSAASASAKV-ADTGPPTDRGVQVTEHGATAALV 443
P + P PP+A A ++ + G R + V A AA +
Sbjct: 368 QPQQPAQP---PPPAARPAGSEPRPEAGSMAFRALGVATQTAIAAAI 411
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 129 bits (324), Expect = 8e-30
Identities = 102/347 (29%), Positives = 159/347 (45%), Gaps = 31/347 (8%)
Query: 64 LRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLG 123
L + DN + + R + + L L+L + + V A + LR+L +LHL + ++
Sbjct: 158 LEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMP 217
Query: 124 EGQLRGLVNLRHLILSNNQLA-ALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNV 182
+ L +L+HL + L + A +L L L ++ NL +P+ A L +
Sbjct: 218 VYAFKRLFHLKHLEIDYWPLLDMMPANSLYGL--NLTSLSVTNTNLSTVPFLAFKHLVYL 275
Query: 183 NTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPL----FSRL---------P 229
L L +N ++++ AG FS L +L L + +L TI P F R+
Sbjct: 276 THLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLET 335
Query: 230 LLARPRGSPASALVLAFGGNPLHCNCELVWLRRLAREDDLE------ACASPPALGGRYF 283
L SP + VL+ NPL C+C L+W+ L R+ L+ CA P + R F
Sbjct: 336 LEENVFSSPRALEVLSINNNPLACDCRLLWI--LQRQPTLQFGGQQPMCAGPDTIRERSF 393
Query: 284 WAVGEEE----FVCEPPVVTHRS-PPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLG 338
F C+ P + + L V G+ L C A GDP+P + WV+P+ R +
Sbjct: 394 KDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFIT 453
Query: 339 NSSRARA--FPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTV 383
S RA +GTLE+ + D G++ CIA+NAAG T LTV
Sbjct: 454 TKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTV 500
Score = 82.8 bits (203), Expect = 9e-16
Identities = 61/193 (31%), Positives = 89/193 (46%), Gaps = 3/193 (1%)
Query: 28 CPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIASVRRRDLANMTGLLH 87
CP RC C Q+ SV C L+ +P + L L+ N + SV + + L
Sbjct: 28 CPARCECSAQNK--SVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEE 85
Query: 88 LSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALA 147
+ LS N I +V GAF +L LR+L L GNRL + G GL NL L +S N++ L
Sbjct: 86 IDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILL 145
Query: 148 AGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLA 207
D L+ L++ N+L + A L ++ L L+ L +VP A S L L
Sbjct: 146 DYMFQD-LHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLI 204
Query: 208 RLDMTSNRLTTIP 220
L + + +P
Sbjct: 205 SLHLKHLNINNMP 217
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 127 bits (318), Expect = 4e-29
Identities = 87/271 (32%), Positives = 131/271 (48%), Gaps = 20/271 (7%)
Query: 112 LHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQL 171
L L NR+ + G R L NL L+L+NNQ+ + +GA +D E L+ L L N ++ +
Sbjct: 67 LDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDL-ENLKYLYLYKNEIQSI 125
Query: 172 PWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLL 231
+A L ++ L L N + ++ +F L KL RL + +NR+T + P F+ L +
Sbjct: 126 DRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGT-FNHLESM 184
Query: 232 ARPRGSPASALVLAFGGNPLHCNCELVWLRRL----AREDDLEA---CASPPALGGRYFW 284
R L N LHC+CE++WL L A + +A C P + GR
Sbjct: 185 KR----------LRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVA 234
Query: 285 AVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRL-LGNSSRA 343
+ EE CE P +T V +G CRA G+P+P + W+ L + SR
Sbjct: 235 TITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRL 294
Query: 344 RAFPNGTLELLVTEPGDGGIFTCIAANAAGE 374
+GTL + T+ D GI+ C+A N AGE
Sbjct: 295 NLLDDGTLMIQNTQETDQGIYQCMAKNVAGE 325
Score = 82.8 bits (203), Expect = 9e-16
Identities = 94/380 (24%), Positives = 132/380 (34%), Gaps = 93/380 (24%)
Query: 88 LSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALA 147
L L N IR + GAF LR L L L+ N++ + G L NL++L L N++ ++
Sbjct: 67 LDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSID 126
Query: 148 AGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLA 207
A A +LE L L +N +E L ++ L + L L +N + + G F+ L +
Sbjct: 127 RQAFKGLA-SLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMK 185
Query: 208 RLDMTSNRL---------------------------------------TTIPPDPLFSRL 228
RL + SN L TI P+ L
Sbjct: 186 RLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCER 245
Query: 229 PLLARPRGSPASALVLAFGGNPLHCNC--------ELVWLR-----------RLAREDD- 268
P R P A V + GN ++ C E++WLR RL DD
Sbjct: 246 P---RITSEPQDADVTS--GNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG 300
Query: 269 -------------LEACASPPALGG--------RYFWAVGEEEFVCEPPVVTHRSPPLAV 307
+ C + G RYF + FV +P V
Sbjct: 301 TLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTE-------V 353
Query: 308 PAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGTLELLVTEPGDGGIFTCI 367
G L C A G P PR+ W L R P+G L + GD G + C
Sbjct: 354 LVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACS 413
Query: 368 AANAAGEATAAVELTVGPPP 387
A N A + V P
Sbjct: 414 ATNNIDSVHATAFIIVQALP 433
Score = 51.6 bits (122), Expect = 2e-06
Identities = 33/114 (28%), Positives = 47/114 (41%), Gaps = 12/114 (10%)
Query: 296 PVVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGTLELLV 355
PV V G L C + G+PEP + W + G + S + P G L +
Sbjct: 525 PVFASIPSDTTVEVGANVQLPCSSQGEPEPAITW-NKDGVQVTESGKFHISPEGFLTIND 583
Query: 356 TEPGDGGIFTCIAANAAGEATAAVELTVGPPPPPQLANSTSCDPPRDGDPDALT 409
P D G + C+A N G A+ ++ L+V P D R+GDP T
Sbjct: 584 VGPADAGRYECVARNTIGSASVSMVLSVNVP-----------DVSRNGDPFVAT 626
Score = 43.5 bits (101), Expect = 6e-04
Identities = 37/134 (27%), Positives = 47/134 (35%), Gaps = 17/134 (12%)
Query: 310 GRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGTLELLVTEPGDGGIFTCIAA 369
G+ +C A G+P P + W G L R +GTL + D G + C A
Sbjct: 447 GQTVDFQCEAKGNPPPVIAWTKG-GSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAV 505
Query: 370 NAAGEATAAVELTVGPPPPPQLANSTSCDPPRDGDPDALTPPSAASASAKVADTGPP--- 426
N G LTV P P A+ P T A+ + G P
Sbjct: 506 NIIGSQKVVAHLTVQPRVTPVFASI----------PSDTTVEVGANVQLPCSSQGEPEPA 555
Query: 427 ---TDRGVQVTEHG 437
GVQVTE G
Sbjct: 556 ITWNKDGVQVTESG 569
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 124 bits (312), Expect = 2e-28
Identities = 109/373 (29%), Positives = 162/373 (43%), Gaps = 53/373 (14%)
Query: 63 ELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSL 122
EL L N + + R + ++ LL L L+ N +R + + F L L L + GN++ ++
Sbjct: 145 ELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAI 204
Query: 123 GEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNV 182
+ R L NLR L+L+ L ++ AL+ ++LE L N L ++P AL ++ +
Sbjct: 205 LDMNFRPLANLRSLVLAGMNLREISDYALEG-LQSLESLSFYDNQLARVPRRALEQVPGL 263
Query: 183 NTLGLDHNLLASVPAGAFS-------------------------RLHKLARLDMTSN-RL 216
L L+ N L V G F+ L +L +LD+T+N RL
Sbjct: 264 KFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRL 323
Query: 217 TTIPPDPLFSRLPLL--ARPRGSPASAL------------VLAFGGNPLHCNCELVWLRR 262
+ I P F LP + + SAL + GNP+ C+C + W
Sbjct: 324 SFIHP-RAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANA 382
Query: 263 LAR-----EDDLEACASPPALGGRYFWAVGEEEFV--CEPPVVTHRSPP-LAVPAGRPAA 314
E CA PP L V E C P + PP L V +G
Sbjct: 383 TGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESMV 442
Query: 315 LRCRAVGDPEPRVRWVSPQGRLLGNS---SRARAFPNGTLELLVTEPGDGGIFTCIAANA 371
L CRA+ +PEP + WV+P G L + R R +P GTLEL + G++TC+A N
Sbjct: 443 LHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNL 502
Query: 372 AGEATAAVELTVG 384
G T V + VG
Sbjct: 503 VGADTKTVSVVVG 515
Score = 72.0 bits (175), Expect = 2e-12
Identities = 67/230 (29%), Positives = 98/230 (42%), Gaps = 15/230 (6%)
Query: 1 MAILPLLLCLLPLAPASSPPQSATP--SPCPRRCRCQTQSL---------PLSVLCPGAG 49
+ + PLLL + A A+ P P PCP +C CQ + +V C
Sbjct: 3 LLVAPLLLAWVAGATAAVP---VVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLF 59
Query: 50 LLFVPPSLDRRAAELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRAL 109
L VPP+L L L N I V + +L + L L LS+N+ F L L
Sbjct: 60 LTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQL 119
Query: 110 RALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLE 169
+LHL+ N+LT L + GL +L+ L L++NQL +A A + L L L+ N L
Sbjct: 120 LSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLR-LHLNSNLLR 178
Query: 170 QLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTI 219
+ L N+ L + N + ++ F L L L + L I
Sbjct: 179 AIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREI 228
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 124 bits (312), Expect = 2e-28
Identities = 109/373 (29%), Positives = 162/373 (43%), Gaps = 53/373 (14%)
Query: 63 ELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSL 122
EL L N + + R + ++ LL L L+ N +R + + F L L L + GN++ ++
Sbjct: 145 ELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAI 204
Query: 123 GEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNV 182
+ R L NLR L+L+ L ++ AL+ ++LE L N L ++P AL ++ +
Sbjct: 205 LDMNFRPLANLRSLVLAGMNLREISDYALEG-LQSLESLSFYDNQLARVPRRALEQVPGL 263
Query: 183 NTLGLDHNLLASVPAGAFS-------------------------RLHKLARLDMTSN-RL 216
L L+ N L V G F+ L +L +LD+T+N RL
Sbjct: 264 KFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRL 323
Query: 217 TTIPPDPLFSRLPLL--ARPRGSPASAL------------VLAFGGNPLHCNCELVWLRR 262
+ I P F LP + + SAL + GNP+ C+C + W
Sbjct: 324 SFIHP-RAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANA 382
Query: 263 LAR-----EDDLEACASPPALGGRYFWAVGEEEFV--CEPPVVTHRSPP-LAVPAGRPAA 314
E CA PP L V E C P + PP L V +G
Sbjct: 383 TGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESMV 442
Query: 315 LRCRAVGDPEPRVRWVSPQGRLLGNS---SRARAFPNGTLELLVTEPGDGGIFTCIAANA 371
L CRA+ +PEP + WV+P G L + R R +P GTLEL + G++TC+A N
Sbjct: 443 LHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNL 502
Query: 372 AGEATAAVELTVG 384
G T V + VG
Sbjct: 503 VGADTKTVSVVVG 515
Score = 72.0 bits (175), Expect = 2e-12
Identities = 67/230 (29%), Positives = 98/230 (42%), Gaps = 15/230 (6%)
Query: 1 MAILPLLLCLLPLAPASSPPQSATP--SPCPRRCRCQTQSL---------PLSVLCPGAG 49
+ + PLLL + A A+ P P PCP +C CQ + +V C
Sbjct: 3 LLVAPLLLAWVAGATAAVP---VVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLF 59
Query: 50 LLFVPPSLDRRAAELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRAL 109
L VPP+L L L N I V + +L + L L LS+N+ F L L
Sbjct: 60 LTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQL 119
Query: 110 RALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLE 169
+LHL+ N+LT L + GL +L+ L L++NQL +A A + L L L+ N L
Sbjct: 120 LSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLR-LHLNSNLLR 178
Query: 170 QLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTI 219
+ L N+ L + N + ++ F L L L + L I
Sbjct: 179 AIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREI 228
>gi|194306623 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 123 bits (308), Expect = 6e-28
Identities = 111/384 (28%), Positives = 158/384 (41%), Gaps = 82/384 (21%)
Query: 95 IRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDC 154
+R V G A++ L L N++T L G + + L L++N++ + GAL
Sbjct: 42 LREVPEGLPANVTTLS---LSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVL 98
Query: 155 AETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSN 214
++ L++LDLS+N + PW L L + L ++HN L S+P A L L L + +N
Sbjct: 99 SQ-LKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNN 157
Query: 215 RLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLAR-------ED 267
RL T+ P F L L+ L NP HC C LVWL+ A E
Sbjct: 158 RLRTLAPG-TFDALSALSH----------LQLYHNPFHCGCGLVWLQAWAASTRVSLPEP 206
Query: 268 DLEACASPPALGGRYFWAVGEEEFVCEPPVV-THRSPPLAVP-----AGRPAALRCRAVG 321
D ACASPPAL G + + C PP V PPL P AG L C A G
Sbjct: 207 DSIACASPPALQGVPVYRL--PALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADG 264
Query: 322 DPEPRVRW----------VSP-------------------QGRLLGNSS----------- 341
P PR++W + P G LL +
Sbjct: 265 HPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQTPTPAPAWP 324
Query: 342 ------RARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPPPPQLANST 395
R A NG+L + + + G++TC A N G + ++ + V PP+ A
Sbjct: 325 APPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATGPPKHA--- 381
Query: 396 SCDPPRDGDPDALTPPSAASASAK 419
P G+PD P S ++AK
Sbjct: 382 ---PGAGGEPDGQAPTSERKSTAK 402
>gi|194306621 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 123 bits (308), Expect = 6e-28
Identities = 111/384 (28%), Positives = 158/384 (41%), Gaps = 82/384 (21%)
Query: 95 IRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDC 154
+R V G A++ L L N++T L G + + L L++N++ + GAL
Sbjct: 42 LREVPEGLPANVTTLS---LSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVL 98
Query: 155 AETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSN 214
++ L++LDLS+N + PW L L + L ++HN L S+P A L L L + +N
Sbjct: 99 SQ-LKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNN 157
Query: 215 RLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLAR-------ED 267
RL T+ P F L L+ L NP HC C LVWL+ A E
Sbjct: 158 RLRTLAPG-TFDALSALSH----------LQLYHNPFHCGCGLVWLQAWAASTRVSLPEP 206
Query: 268 DLEACASPPALGGRYFWAVGEEEFVCEPPVV-THRSPPLAVP-----AGRPAALRCRAVG 321
D ACASPPAL G + + C PP V PPL P AG L C A G
Sbjct: 207 DSIACASPPALQGVPVYRL--PALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADG 264
Query: 322 DPEPRVRW----------VSP-------------------QGRLLGNSS----------- 341
P PR++W + P G LL +
Sbjct: 265 HPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQTPTPAPAWP 324
Query: 342 ------RARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPPPPQLANST 395
R A NG+L + + + G++TC A N G + ++ + V PP+ A
Sbjct: 325 APPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATGPPKHA--- 381
Query: 396 SCDPPRDGDPDALTPPSAASASAK 419
P G+PD P S ++AK
Sbjct: 382 ---PGAGGEPDGQAPTSERKSTAK 402
>gi|39930401 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 123 bits (308), Expect = 6e-28
Identities = 111/384 (28%), Positives = 158/384 (41%), Gaps = 82/384 (21%)
Query: 95 IRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDC 154
+R V G A++ L L N++T L G + + L L++N++ + GAL
Sbjct: 42 LREVPEGLPANVTTLS---LSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVL 98
Query: 155 AETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSN 214
++ L++LDLS+N + PW L L + L ++HN L S+P A L L L + +N
Sbjct: 99 SQ-LKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNN 157
Query: 215 RLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLAR-------ED 267
RL T+ P F L L+ L NP HC C LVWL+ A E
Sbjct: 158 RLRTLAPG-TFDALSALSH----------LQLYHNPFHCGCGLVWLQAWAASTRVSLPEP 206
Query: 268 DLEACASPPALGGRYFWAVGEEEFVCEPPVV-THRSPPLAVP-----AGRPAALRCRAVG 321
D ACASPPAL G + + C PP V PPL P AG L C A G
Sbjct: 207 DSIACASPPALQGVPVYRL--PALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADG 264
Query: 322 DPEPRVRW----------VSP-------------------QGRLLGNSS----------- 341
P PR++W + P G LL +
Sbjct: 265 HPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQTPTPAPAWP 324
Query: 342 ------RARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPPPPQLANST 395
R A NG+L + + + G++TC A N G + ++ + V PP+ A
Sbjct: 325 APPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATGPPKHA--- 381
Query: 396 SCDPPRDGDPDALTPPSAASASAK 419
P G+PD P S ++AK
Sbjct: 382 ---PGAGGEPDGQAPTSERKSTAK 402
>gi|194306618 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 123 bits (308), Expect = 6e-28
Identities = 111/384 (28%), Positives = 158/384 (41%), Gaps = 82/384 (21%)
Query: 95 IRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDC 154
+R V G A++ L L N++T L G + + L L++N++ + GAL
Sbjct: 42 LREVPEGLPANVTTLS---LSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVL 98
Query: 155 AETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSN 214
++ L++LDLS+N + PW L L + L ++HN L S+P A L L L + +N
Sbjct: 99 SQ-LKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNN 157
Query: 215 RLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLAR-------ED 267
RL T+ P F L L+ L NP HC C LVWL+ A E
Sbjct: 158 RLRTLAPG-TFDALSALSH----------LQLYHNPFHCGCGLVWLQAWAASTRVSLPEP 206
Query: 268 DLEACASPPALGGRYFWAVGEEEFVCEPPVV-THRSPPLAVP-----AGRPAALRCRAVG 321
D ACASPPAL G + + C PP V PPL P AG L C A G
Sbjct: 207 DSIACASPPALQGVPVYRL--PALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADG 264
Query: 322 DPEPRVRW----------VSP-------------------QGRLLGNSS----------- 341
P PR++W + P G LL +
Sbjct: 265 HPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQTPTPAPAWP 324
Query: 342 ------RARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPPPPQLANST 395
R A NG+L + + + G++TC A N G + ++ + V PP+ A
Sbjct: 325 APPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATGPPKHA--- 381
Query: 396 SCDPPRDGDPDALTPPSAASASAK 419
P G+PD P S ++AK
Sbjct: 382 ---PGAGGEPDGQAPTSERKSTAK 402
>gi|193083136 leucine-rich repeat, immunoglobulin-like and
transmembrane domains 3 [Homo sapiens]
Length = 634
Score = 117 bits (293), Expect = 3e-26
Identities = 97/309 (31%), Positives = 143/309 (46%), Gaps = 24/309 (7%)
Query: 130 LVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDH 189
LV L++L ++ N +A++ + + + L +L L N+L PW +L + + TL L +
Sbjct: 35 LVELQYLWVTYNSVASIDPSSFYNLKQ-LHELRLDGNSLAAFPWASLLDMPLLRTLDLHN 93
Query: 190 NLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRG----SPASALVLA 245
N + SVP A L LA LD++SNRLTT+PPD L S L++ P G SP S ++L
Sbjct: 94 NKITSVPNEALRYLKNLAYLDLSSNRLTTLPPDFLESWTHLVSTPSGVLDLSP-SRIILG 152
Query: 246 FGGNPLHCNCELVWLRRLARE--------DDLEACASPPALGGRYFWAVGEEEFVCEPPV 297
NP C+C + + L++ D L C+ P L G F E E +P V
Sbjct: 153 LQDNPWFCDCHISKMIELSKVVDPAIVLLDPLMTCSEPERLTGILFQR-AELEHCLKPSV 211
Query: 298 VTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWV----SPQGRLLGNSSRARAFPNGTLEL 353
+T + ++ G LRC A G P P++ W SP + S + L
Sbjct: 212 MTSATKIMSA-LGSNVLLRCDATGFPTPQITWTRSDSSPVNYTVIQESPEEGVRWSIMSL 270
Query: 354 LVTEPGDGGIFTCIAANAAGEATAAVELTV----GPPPPPQLANSTSCDPPRDGDPDALT 409
D G + C A N AG + A V +TV P PP + T P D P +
Sbjct: 271 TGISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIPPDTSERTGDHPEWDVQPGSGR 330
Query: 410 PPSAASASA 418
S +SAS+
Sbjct: 331 STSVSSASS 339
Score = 45.8 bits (107), Expect = 1e-04
Identities = 35/113 (30%), Positives = 52/113 (46%), Gaps = 8/113 (7%)
Query: 69 NFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLR 128
N +AS+ N+ L L L N++ + D+ LR L L N++TS+ LR
Sbjct: 46 NSVASIDPSSFYNLKQLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALR 105
Query: 129 GLVNLRHLILSNNQLAALAAGALDDCAETLED----LDLSYN----NLEQLPW 173
L NL +L LS+N+L L L+ + LDLS + L+ PW
Sbjct: 106 YLKNLAYLDLSSNRLTTLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPW 158
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 108 bits (271), Expect = 1e-23
Identities = 103/394 (26%), Positives = 167/394 (42%), Gaps = 79/394 (20%)
Query: 66 LADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSL--- 122
L +N + + + L+ ++ L L ++ N + ++ GAF L L LHL+ NRL +
Sbjct: 123 LEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSK 182
Query: 123 -------------GEGQL--------RGLVNLRHLILSNNQLAALAAGALDDCAETLEDL 161
GE + + L+NLR L+++ L + AL E LE +
Sbjct: 183 WFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGL-ENLESI 241
Query: 162 DLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSR------------------- 202
N L ++P AL ++ N+ L L+ N + + G FS
Sbjct: 242 SFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISID 301
Query: 203 ------LHKLARLDMTSN-RLTTIPPDPLFSRLPLLARP--RGSPASALV---------- 243
L L +++ T+N RL+ I P+ F RLP L + SAL
Sbjct: 302 SLAVDNLPDLRKIEATNNPRLSYIHPNAFF-RLPKLESLMLNSNALSALYHGTIESLPNL 360
Query: 244 --LAFGGNPLHCNCELVWLR------RLAREDDLEACASPPALGGRYFWAVGEEEF--VC 293
++ NP+ C+C + W+ R D L C PP G+ V + +C
Sbjct: 361 KEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSL-FCVDPPEFQGQNVRQVHFRDMMEIC 419
Query: 294 EPPVVTHRSPP-LAVPAGRPAALRCRAVGDPEPRVRWVSPQG-RLLGNSSRARAF--PNG 349
P + P L V AG + CRA +P+P + W++P G +LL N+ + + G
Sbjct: 420 LPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEG 479
Query: 350 TLELLVTEPGDGGIFTCIAANAAGEATAAVELTV 383
TL++ P +GG++TCIA N G +V + V
Sbjct: 480 TLDINGVTPKEGGLYTCIATNLVGADLKSVMIKV 513
Score = 62.8 bits (151), Expect = 9e-10
Identities = 60/208 (28%), Positives = 90/208 (43%), Gaps = 15/208 (7%)
Query: 28 CPRRCRCQTQS--LPLSVL-------CPGAGLLFVPPSLDRRAAELRLADNFIASVRRRD 78
CPR C C+ + P S+ C GLL P L L L N IA +
Sbjct: 29 CPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
Query: 79 --LANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHL 136
N+TGL LS+N + V + L +++L+ N+LT L E L L NL+ L
Sbjct: 89 DFPVNLTGL---DLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQEL 145
Query: 137 ILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVP 196
+++N L+ ++ GA L L L+ N L+ + + L N+ L + N + +
Sbjct: 146 YINHNLLSTISPGAFIGLHNLLR-LHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIK 204
Query: 197 AGAFSRLHKLARLDMTSNRLTTIPPDPL 224
F L L L + LT IP + L
Sbjct: 205 DMNFKPLINLRSLVIAGINLTEIPDNAL 232
Score = 58.2 bits (139), Expect = 2e-08
Identities = 43/121 (35%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 131 VNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHN 190
VNL L LS N L+++ + + L + L N L +LP + L L N+ L ++HN
Sbjct: 92 VNLTGLDLSQNNLSSVTNINVKKMPQLLS-VYLEENKLTELPEKCLSELSNLQELYINHN 150
Query: 191 LLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNP 250
LL+++ GAF LH L RL + SNRL I F LP L +L G NP
Sbjct: 151 LLSTISPGAFIGLHNLLRLHLNSNRLQMI-NSKWFDALPNLE----------ILMIGENP 199
Query: 251 L 251
+
Sbjct: 200 I 200
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 108 bits (271), Expect = 1e-23
Identities = 103/394 (26%), Positives = 167/394 (42%), Gaps = 79/394 (20%)
Query: 66 LADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSL--- 122
L +N + + + L+ ++ L L ++ N + ++ GAF L L LHL+ NRL +
Sbjct: 123 LEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSK 182
Query: 123 -------------GEGQL--------RGLVNLRHLILSNNQLAALAAGALDDCAETLEDL 161
GE + + L+NLR L+++ L + AL E LE +
Sbjct: 183 WFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGL-ENLESI 241
Query: 162 DLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSR------------------- 202
N L ++P AL ++ N+ L L+ N + + G FS
Sbjct: 242 SFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISID 301
Query: 203 ------LHKLARLDMTSN-RLTTIPPDPLFSRLPLLARP--RGSPASALV---------- 243
L L +++ T+N RL+ I P+ F RLP L + SAL
Sbjct: 302 SLAVDNLPDLRKIEATNNPRLSYIHPNAFF-RLPKLESLMLNSNALSALYHGTIESLPNL 360
Query: 244 --LAFGGNPLHCNCELVWLR------RLAREDDLEACASPPALGGRYFWAVGEEEF--VC 293
++ NP+ C+C + W+ R D L C PP G+ V + +C
Sbjct: 361 KEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSL-FCVDPPEFQGQNVRQVHFRDMMEIC 419
Query: 294 EPPVVTHRSPP-LAVPAGRPAALRCRAVGDPEPRVRWVSPQG-RLLGNSSRARAF--PNG 349
P + P L V AG + CRA +P+P + W++P G +LL N+ + + G
Sbjct: 420 LPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEG 479
Query: 350 TLELLVTEPGDGGIFTCIAANAAGEATAAVELTV 383
TL++ P +GG++TCIA N G +V + V
Sbjct: 480 TLDINGVTPKEGGLYTCIATNLVGADLKSVMIKV 513
Score = 62.8 bits (151), Expect = 9e-10
Identities = 60/208 (28%), Positives = 90/208 (43%), Gaps = 15/208 (7%)
Query: 28 CPRRCRCQTQS--LPLSVL-------CPGAGLLFVPPSLDRRAAELRLADNFIASVRRRD 78
CPR C C+ + P S+ C GLL P L L L N IA +
Sbjct: 29 CPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
Query: 79 --LANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHL 136
N+TGL LS+N + V + L +++L+ N+LT L E L L NL+ L
Sbjct: 89 DFPVNLTGL---DLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQEL 145
Query: 137 ILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVP 196
+++N L+ ++ GA L L L+ N L+ + + L N+ L + N + +
Sbjct: 146 YINHNLLSTISPGAFIGLHNLLR-LHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIK 204
Query: 197 AGAFSRLHKLARLDMTSNRLTTIPPDPL 224
F L L L + LT IP + L
Sbjct: 205 DMNFKPLINLRSLVIAGINLTEIPDNAL 232
Score = 58.2 bits (139), Expect = 2e-08
Identities = 43/121 (35%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 131 VNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHN 190
VNL L LS N L+++ + + L + L N L +LP + L L N+ L ++HN
Sbjct: 92 VNLTGLDLSQNNLSSVTNINVKKMPQLLS-VYLEENKLTELPEKCLSELSNLQELYINHN 150
Query: 191 LLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNP 250
LL+++ GAF LH L RL + SNRL I F LP L +L G NP
Sbjct: 151 LLSTISPGAFIGLHNLLRLHLNSNRLQMI-NSKWFDALPNLE----------ILMIGENP 199
Query: 251 L 251
+
Sbjct: 200 I 200
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 108 bits (271), Expect = 1e-23
Identities = 103/394 (26%), Positives = 167/394 (42%), Gaps = 79/394 (20%)
Query: 66 LADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSL--- 122
L +N + + + L+ ++ L L ++ N + ++ GAF L L LHL+ NRL +
Sbjct: 123 LEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSK 182
Query: 123 -------------GEGQL--------RGLVNLRHLILSNNQLAALAAGALDDCAETLEDL 161
GE + + L+NLR L+++ L + AL E LE +
Sbjct: 183 WFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGL-ENLESI 241
Query: 162 DLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSR------------------- 202
N L ++P AL ++ N+ L L+ N + + G FS
Sbjct: 242 SFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISID 301
Query: 203 ------LHKLARLDMTSN-RLTTIPPDPLFSRLPLLARP--RGSPASALV---------- 243
L L +++ T+N RL+ I P+ F RLP L + SAL
Sbjct: 302 SLAVDNLPDLRKIEATNNPRLSYIHPNAFF-RLPKLESLMLNSNALSALYHGTIESLPNL 360
Query: 244 --LAFGGNPLHCNCELVWLR------RLAREDDLEACASPPALGGRYFWAVGEEEF--VC 293
++ NP+ C+C + W+ R D L C PP G+ V + +C
Sbjct: 361 KEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSL-FCVDPPEFQGQNVRQVHFRDMMEIC 419
Query: 294 EPPVVTHRSPP-LAVPAGRPAALRCRAVGDPEPRVRWVSPQG-RLLGNSSRARAF--PNG 349
P + P L V AG + CRA +P+P + W++P G +LL N+ + + G
Sbjct: 420 LPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEG 479
Query: 350 TLELLVTEPGDGGIFTCIAANAAGEATAAVELTV 383
TL++ P +GG++TCIA N G +V + V
Sbjct: 480 TLDINGVTPKEGGLYTCIATNLVGADLKSVMIKV 513
Score = 62.8 bits (151), Expect = 9e-10
Identities = 60/208 (28%), Positives = 90/208 (43%), Gaps = 15/208 (7%)
Query: 28 CPRRCRCQTQS--LPLSVL-------CPGAGLLFVPPSLDRRAAELRLADNFIASVRRRD 78
CPR C C+ + P S+ C GLL P L L L N IA +
Sbjct: 29 CPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
Query: 79 --LANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHL 136
N+TGL LS+N + V + L +++L+ N+LT L E L L NL+ L
Sbjct: 89 DFPVNLTGL---DLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQEL 145
Query: 137 ILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVP 196
+++N L+ ++ GA L L L+ N L+ + + L N+ L + N + +
Sbjct: 146 YINHNLLSTISPGAFIGLHNLLR-LHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIK 204
Query: 197 AGAFSRLHKLARLDMTSNRLTTIPPDPL 224
F L L L + LT IP + L
Sbjct: 205 DMNFKPLINLRSLVIAGINLTEIPDNAL 232
Score = 58.2 bits (139), Expect = 2e-08
Identities = 43/121 (35%), Positives = 60/121 (49%), Gaps = 12/121 (9%)
Query: 131 VNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHN 190
VNL L LS N L+++ + + L + L N L +LP + L L N+ L ++HN
Sbjct: 92 VNLTGLDLSQNNLSSVTNINVKKMPQLLS-VYLEENKLTELPEKCLSELSNLQELYINHN 150
Query: 191 LLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNP 250
LL+++ GAF LH L RL + SNRL I F LP L +L G NP
Sbjct: 151 LLSTISPGAFIGLHNLLRLHLNSNRLQMI-NSKWFDALPNLE----------ILMIGENP 199
Query: 251 L 251
+
Sbjct: 200 I 200
>gi|41582239 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
Length = 428
Score = 107 bits (268), Expect = 3e-23
Identities = 93/308 (30%), Positives = 129/308 (41%), Gaps = 48/308 (15%)
Query: 112 LHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQL 171
L L NRL L EG R + L+ L L++N++ +AAGAL + L+ LDLS+N +
Sbjct: 55 LSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSH-LKSLDLSHNLISDF 113
Query: 172 PWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLL 231
W L L + L +D N L +P AF L L L + NRL T L
Sbjct: 114 AWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHT------------L 161
Query: 232 ARPRGSPASALV-LAFGGNPLHCNCELVWLRRLA-------REDDLEACASPPALGGRYF 283
A +P +AL L NP C C +VWL+ A E D AC SP L G
Sbjct: 162 AEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPL 221
Query: 284 WAVGEEEFVCEPPVVTHRSPP----LAVPAGRPAALRCRAVGDPEPRVRW---------- 329
+ C P V P + G AL C G P P++ W
Sbjct: 222 SRL--PPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVE 279
Query: 330 -----VSPQGRLL------GNSSRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAA 378
V GR L + R +AF NG+L + + G ++C+A N G A ++
Sbjct: 280 ITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESS 339
Query: 379 VELTVGPP 386
V++ + P
Sbjct: 340 VDVALATP 347
Score = 52.4 bits (124), Expect = 1e-06
Identities = 30/78 (38%), Positives = 42/78 (53%)
Query: 64 LRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLG 123
L L+ N I+ DL N++ L L + N + + AF LRALR+L L+ NRL +L
Sbjct: 103 LDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLA 162
Query: 124 EGQLRGLVNLRHLILSNN 141
EG L L HL ++ N
Sbjct: 163 EGTFTPLTALSHLQINEN 180
>gi|5031809 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
Length = 428
Score = 107 bits (268), Expect = 3e-23
Identities = 93/308 (30%), Positives = 129/308 (41%), Gaps = 48/308 (15%)
Query: 112 LHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQL 171
L L NRL L EG R + L+ L L++N++ +AAGAL + L+ LDLS+N +
Sbjct: 55 LSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSH-LKSLDLSHNLISDF 113
Query: 172 PWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLL 231
W L L + L +D N L +P AF L L L + NRL T L
Sbjct: 114 AWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHT------------L 161
Query: 232 ARPRGSPASALV-LAFGGNPLHCNCELVWLRRLA-------REDDLEACASPPALGGRYF 283
A +P +AL L NP C C +VWL+ A E D AC SP L G
Sbjct: 162 AEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPL 221
Query: 284 WAVGEEEFVCEPPVVTHRSPP----LAVPAGRPAALRCRAVGDPEPRVRW---------- 329
+ C P V P + G AL C G P P++ W
Sbjct: 222 SRL--PPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVE 279
Query: 330 -----VSPQGRLL------GNSSRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAA 378
V GR L + R +AF NG+L + + G ++C+A N G A ++
Sbjct: 280 ITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESS 339
Query: 379 VELTVGPP 386
V++ + P
Sbjct: 340 VDVALATP 347
Score = 52.4 bits (124), Expect = 1e-06
Identities = 30/78 (38%), Positives = 42/78 (53%)
Query: 64 LRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLG 123
L L+ N I+ DL N++ L L + N + + AF LRALR+L L+ NRL +L
Sbjct: 103 LDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLA 162
Query: 124 EGQLRGLVNLRHLILSNN 141
EG L L HL ++ N
Sbjct: 163 EGTFTPLTALSHLQINEN 180
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 106 bits (265), Expect = 6e-23
Identities = 87/297 (29%), Positives = 122/297 (41%), Gaps = 45/297 (15%)
Query: 26 SPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIASVRRRDLANMTGL 85
S CP C C ++ C G GL +P ++ R L L N I + + D A + L
Sbjct: 32 SACPALCTCTGTTVD----CHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQL 87
Query: 86 LHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAA 145
L L N I V GAF D++ L L L+ N+L L E L+ NNQ
Sbjct: 88 RVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPE-----------LLFQNNQ--- 133
Query: 146 LAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHK 205
L LDLS N ++ +P +A ++ L LD N ++ + GAF L
Sbjct: 134 -----------ALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRG 182
Query: 206 LARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLAR 265
L L + +N +TTIP F+ +P L R N L C+C L WL + R
Sbjct: 183 LEVLTLNNNNITTIPVSS-FNHMPKLRTFR----------LHSNHLFCDCHLAWLSQWLR 231
Query: 266 EDD----LEACASPPALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGR-PAALRC 317
+ C+ P +L G V + EF C R P + +G PA C
Sbjct: 232 QRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTC 288
Score = 82.0 bits (201), Expect = 1e-15
Identities = 70/272 (25%), Positives = 108/272 (39%), Gaps = 69/272 (25%)
Query: 28 CPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIASVRRRDL-ANMTGLL 86
CP +CRC+ V C L +P + + AELRL +N I+ + + +T L
Sbjct: 513 CPHKCRCEANV----VECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLK 568
Query: 87 HLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAAL 146
++LS N + + GAF ++ LHL N+L S+ G RGL LR L+L NN+++ +
Sbjct: 569 KINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCI 628
Query: 147 AAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKL 206
+N ++ L NV L L N + +V GAF L L
Sbjct: 629 ------------------HN-------DSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSL 663
Query: 207 ARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLARE 266
+ L++ + NP +CNC+L WL R+
Sbjct: 664 STLNLLA-----------------------------------NPFNCNCQLAWLGGWLRK 688
Query: 267 DDL----EACASPPALGGRYFWAVGEEEFVCE 294
+ C +P L V +F CE
Sbjct: 689 RKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCE 720
Score = 81.6 bits (200), Expect = 2e-15
Identities = 69/279 (24%), Positives = 103/279 (36%), Gaps = 68/279 (24%)
Query: 19 PPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIASVRRRD 78
P + + CP C C + C G GL +P +L E+RL N I S+
Sbjct: 273 PTCTLSSGSCPAMCTCSNGIVD----CRGKGLTAIPANLPETMTEIRLELNGIKSIPPGA 328
Query: 79 LANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLIL 138
+ L + LS N I +A AF LR+L +L L GN++T L G GL L+ L+L
Sbjct: 329 FSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLL 388
Query: 139 SNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAG 198
+ N++ + A D L N++ L L N + S+ G
Sbjct: 389 NANKINCIRPDAFQD-------------------------LQNLSLLSLYDNKIQSLAKG 423
Query: 199 AFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELV 258
F+ L + L + NP C+C L
Sbjct: 424 TFTSLRAIQTLHLAQ-----------------------------------NPFICDCNLK 448
Query: 259 WLRRLAREDDLEA----CASPPALGGRYFWAVGEEEFVC 293
WL R + +E CASP L + + ++F C
Sbjct: 449 WLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRC 487
Score = 68.2 bits (165), Expect = 2e-11
Identities = 59/202 (29%), Positives = 91/202 (45%), Gaps = 47/202 (23%)
Query: 112 LHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQL 171
L+LDGN+ T L GQL L+ + LSNN++++L+ + S+ N+ QL
Sbjct: 766 LYLDGNQFT-LVPGQLSTFKYLQLVDLSNNKISSLS--------------NSSFTNMSQL 810
Query: 172 PWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLL 231
TL L +N L +P AF L L L + N ++T+ + +F+ + L
Sbjct: 811 -----------TTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQ-EGIFADVTSL 858
Query: 232 ARPRGSPASALVLAFGGNPLHCNCELVWLRRLA----REDDLEACASPPALGGRYFWAVG 287
+ LA G NPL+C+C L WL +E + CA P + G+
Sbjct: 859 SH----------LAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTP 908
Query: 288 EEEFVCEPPVVTHRSPPLAVPA 309
++F C+ P P LAV A
Sbjct: 909 AKKFECQGP------PTLAVQA 924
Score = 53.9 bits (128), Expect = 4e-07
Identities = 42/143 (29%), Positives = 61/143 (42%), Gaps = 28/143 (19%)
Query: 25 PSP-CPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRL----------------- 66
P P CP+ C C L V C L +P + + EL L
Sbjct: 730 PRPQCPQECAC----LDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKY 785
Query: 67 ------ADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLT 120
++N I+S+ NM+ L L LS N ++ + AF LR+LR L L GN ++
Sbjct: 786 LQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDIS 845
Query: 121 SLGEGQLRGLVNLRHLILSNNQL 143
+L EG + +L HL + N L
Sbjct: 846 TLQEGIFADVTSLSHLAIGANPL 868
>gi|14149694 retina specific protein PAL [Homo sapiens]
Length = 623
Score = 106 bits (264), Expect = 7e-23
Identities = 114/400 (28%), Positives = 149/400 (37%), Gaps = 75/400 (18%)
Query: 8 LCLLPLAPASSPPQSATPSPCPRRCRCQTQ-----SLPLSVLCPGAGLLFVPPSLDRRAA 62
L +L L + PPQ+ CP +C C S +V+C + P S+ +
Sbjct: 5 LGMLWLLALAWPPQAR--GFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTS 62
Query: 63 ELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSL 122
LRL R IR V AF L L L L N L+ L
Sbjct: 63 RLRL------------------------ERTAIRRVPGEAFRPLGRLEQLWLPYNALSEL 98
Query: 123 GEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNV 182
LRGL LR L L N+LAA PW AL +
Sbjct: 99 NALMLRGLRRLRELRLPGNRLAAF-------------------------PWAALRDAPKL 133
Query: 183 NTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPL---LARPRGSPA 239
L L N L++VPA A L L LD++SN+L +P + + S L + P P
Sbjct: 134 RLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHHPR 193
Query: 240 SALVLAFGGNPLHCNCELV--------WLRRLAREDDLEACASPPALGGRYFWAVGEEEF 291
VL NP C+C L W LA + CASP +L G F + E
Sbjct: 194 R--VLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAFSQL--ELR 249
Query: 292 VCEPPVVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGTL 351
C+ P + + G A LRC A G P P + W GR L + +GT
Sbjct: 250 KCQGPELHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTS 309
Query: 352 ELLVTEPG----DGGIFTCIAANAAGEATAAVELTVGPPP 387
L+ P D G + C A N G + + L V PP
Sbjct: 310 WTLLGLPAVSHLDSGDYICQAKNFLGASETVISLIVTEPP 349
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 102 bits (253), Expect = 1e-21
Identities = 87/303 (28%), Positives = 123/303 (40%), Gaps = 51/303 (16%)
Query: 6 LLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELR 65
L L L + S PP A CP +C C S+ C G GL VP + R A L
Sbjct: 16 LALALALASVLSGPPAVA----CPTKCTCSAASVD----CHGLGLRAVPRGIPRNAERLD 67
Query: 66 LADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEG 125
L N I + + D A + L L L N + + GAF DL+ L L L+ N+L L E
Sbjct: 68 LDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPE- 126
Query: 126 QLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTL 185
L L LDLS N ++ +P +A + +V L
Sbjct: 127 ------------------------LLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNL 162
Query: 186 GLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLA 245
LD+N ++ + GAF L L L + +N ++ I F+ +P + L
Sbjct: 163 QLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTS-FNHMPKIR----------TLR 211
Query: 246 FGGNPLHCNCELVWLRRLARE----DDLEACASPPALGGRYFWAVGEEEFVCEPPVVTHR 301
N L+C+C L WL R+ C +P L G V ++E+VC P H
Sbjct: 212 LHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAP---HS 268
Query: 302 SPP 304
PP
Sbjct: 269 EPP 271
Score = 89.7 bits (221), Expect = 7e-18
Identities = 70/285 (24%), Positives = 111/285 (38%), Gaps = 69/285 (24%)
Query: 14 APASSPPQ-SATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIA 72
AP S PP +A CP C C + C G GL+ +P +L E+RL N I
Sbjct: 265 APHSEPPSCNANSISCPSPCTCSNNIVD----CRGKGLMEIPANLPEGIVEIRLEQNSIK 320
Query: 73 SVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVN 132
++ L + +S+N I +A AF L++L +L L GN++T + +G GLV+
Sbjct: 321 AIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVS 380
Query: 133 LRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLL 192
L+ L+L+ N++ L D L N+N L L N L
Sbjct: 381 LQLLLLNANKINCLRVNTFQD-------------------------LQNLNLLSLYDNKL 415
Query: 193 ASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLH 252
++ G F+ L + L + NP
Sbjct: 416 QTISKGLFAPLQSIQTLHLAQ-----------------------------------NPFV 440
Query: 253 CNCELVWLRRLAREDDLEA----CASPPALGGRYFWAVGEEEFVC 293
C+C L WL +++ +E C+SP L + + ++F C
Sbjct: 441 CDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRC 485
Score = 71.2 bits (173), Expect = 3e-12
Identities = 55/190 (28%), Positives = 83/190 (43%), Gaps = 41/190 (21%)
Query: 112 LHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQL 171
L+L+GN LT++ R L LRHL L +DLS N++ L
Sbjct: 757 LYLEGNHLTAVP----RELSALRHLTL----------------------IDLSNNSISML 790
Query: 172 PWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLL 231
+ +++TL L +N L +P AF+ L L L + N ++++ P+ F+ L L
Sbjct: 791 TNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSV-PEGSFNDLTSL 849
Query: 232 ARPRGSPASALVLAFGGNPLHCNCELVWLRRLA----REDDLEACASPPALGGRYFWAVG 287
+ LA G NPLHC+C L WL +E + C+SP + R
Sbjct: 850 SH----------LALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTP 899
Query: 288 EEEFVCEPPV 297
F C+ PV
Sbjct: 900 THRFQCKGPV 909
Score = 69.7 bits (169), Expect = 8e-12
Identities = 68/271 (25%), Positives = 104/271 (38%), Gaps = 67/271 (24%)
Query: 28 CPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIASVRRRDLANMTGLLH 87
CP +CRC+ + C L+ +P L +LRL DN ++ +
Sbjct: 505 CPEKCRCEGTIVD----CSNQKLVRIPSHLPEYVTDLRLNDNEVSVLE------------ 548
Query: 88 LSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALA 147
A G F + L NLR + LSNN++ +
Sbjct: 549 -----------ATGIF------------------------KKLPNLRKINLSNNKIKEVR 573
Query: 148 AGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLA 207
GA D A ++++L L+ N LE + L + TL L NL+ V F+ L +
Sbjct: 574 EGAFDGAA-SVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVR 632
Query: 208 RLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLARED 267
L + NR+TTI P F+ L S + NP +CNC L WL + R+
Sbjct: 633 LLSLYDNRITTITPG-AFTTL----------VSLSTINLLSNPFNCNCHLAWLGKWLRKR 681
Query: 268 DLEA----CASPPALGGRYFWAVGEEEFVCE 294
+ + C P L V ++F C+
Sbjct: 682 RIVSGNPRCQKPFFLKEIPIQDVAIQDFTCD 712
Score = 60.5 bits (145), Expect = 5e-09
Identities = 43/139 (30%), Positives = 59/139 (42%), Gaps = 27/139 (19%)
Query: 28 CPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIASVRRR---------- 77
CP +C C + V C GL +P + + EL L N + +V R
Sbjct: 725 CPEQCTC----METVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLI 780
Query: 78 -------------DLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGE 124
+NM+ L L LS N +R + AF LR+LR L L GN ++S+ E
Sbjct: 781 DLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPE 840
Query: 125 GQLRGLVNLRHLILSNNQL 143
G L +L HL L N L
Sbjct: 841 GSFNDLTSLSHLALGTNPL 859
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 101 bits (251), Expect = 2e-21
Identities = 99/347 (28%), Positives = 148/347 (42%), Gaps = 27/347 (7%)
Query: 63 ELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDG-NRLTS 121
+L L + S+ L+++ GL+ L L I + +F L L+ L + L +
Sbjct: 195 QLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDT 254
Query: 122 LGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGN 181
+ L GL NL L +++ L A+ A+ L L+LSYN + + L L
Sbjct: 255 MTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVY-LRFLNLSYNPISTIEGSMLHELLR 312
Query: 182 VNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASA 241
+ + L LA V AF L+ L L+++ N+LTT+ S +
Sbjct: 313 LQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHS-----------VGNL 361
Query: 242 LVLAFGGNPLHCNCELVWLRR----LAREDDLEACASPPALGGRYFWAVGE----EEFVC 293
L NPL C+C L+W+ R L CA+P + G+ F + F C
Sbjct: 362 ETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTC 421
Query: 294 EPPVVTHR-SPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRAR--AFPNGT 350
+ R + + V G CRA GDP P + W+SP+ L+ S R FP+GT
Sbjct: 422 RRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGT 481
Query: 351 LELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPPP--PQLANST 395
LE+ + D G + CIAANA G + L V P P N T
Sbjct: 482 LEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKT 528
Score = 85.1 bits (209), Expect = 2e-16
Identities = 71/225 (31%), Positives = 99/225 (44%), Gaps = 5/225 (2%)
Query: 5 PLLLCLLP-LAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAE 63
PLL C P L S + + CP RC C Q +VLC + VP +
Sbjct: 18 PLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDR--AVLCHRKRFVAVPEGIPTETRL 75
Query: 64 LRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLG 123
L L N I ++ + + A+ L L L+ N + V GAF +L LR L L NRL +
Sbjct: 76 LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIP 135
Query: 124 EGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVN 183
G GL NL L +S N++ L D L+ L++ N+L + A L ++
Sbjct: 136 LGVFTGLSNLTKLDISENKIVILLDYMFQD-LYNLKSLEVGDNDLVYISHRAFSGLNSLE 194
Query: 184 TLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRL 228
L L+ L S+P A S LH L L + + I D F RL
Sbjct: 195 QLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAI-RDYSFKRL 238
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,155,570
Number of Sequences: 37866
Number of extensions: 1775268
Number of successful extensions: 17454
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 375
Number of HSP's successfully gapped in prelim test: 340
Number of HSP's that attempted gapping in prelim test: 12136
Number of HSP's gapped (non-prelim): 3788
length of query: 628
length of database: 18,247,518
effective HSP length: 108
effective length of query: 520
effective length of database: 14,157,990
effective search space: 7362154800
effective search space used: 7362154800
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.