Search of human proteins with 4826762

Search of human proteins with 4826762

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4826762 haptoglobin isoform 1 preproprotein [Homo sapiens]
         (406 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4826762 haptoglobin isoform 1 preproprotein [Homo sapiens]         852   0.0  
gi|186910296 haptoglobin isoform 2 preproprotein [Homo sapiens]       669   0.0  
gi|45580723 haptoglobin-related protein [Homo sapiens]                612   e-175
gi|66347875 complement component 1, r subcomponent [Homo sapiens]     182   6e-46
gi|4502495 complement component 1, s subcomponent precursor [Hom...   166   5e-41
gi|41393602 complement component 1, s subcomponent precursor [Ho...   166   5e-41
gi|21264357 mannan-binding lectin serine protease 1 isoform 1 pr...   159   3e-39
gi|21264359 mannan-binding lectin serine protease 1 isoform 2 pr...   159   4e-39
gi|21264363 mannan-binding lectin serine protease 2 isoform 1 pr...   144   1e-34
gi|7706083 complement component 1, r subcomponent-like precursor...   136   4e-32
gi|10518503 coagulation factor VII isoform b precursor [Homo sap...   122   4e-28
gi|4503645 coagulation factor VII isoform a precursor [Homo sapi...   122   4e-28
gi|148806900 epidermis-specific serine protease-like protein [Ho...   119   4e-27
gi|4503625 coagulation factor X preproprotein [Homo sapiens]          112   5e-25
gi|4503649 coagulation factor IX preproprotein [Homo sapiens]         106   3e-23
gi|13994276 marapsin [Homo sapiens]                                   105   1e-22
gi|4506115 protein C [Homo sapiens]                                   104   2e-22
gi|4506153 prostasin preproprotein [Homo sapiens]                     102   8e-22
gi|110578663 hypothetical protein LOC203074 [Homo sapiens]            101   1e-21
gi|4503635 coagulation factor II preproprotein [Homo sapiens]         100   4e-21
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]            99   5e-21
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]            99   7e-21
gi|4503627 coagulation factor XI precursor [Homo sapiens]              97   3e-20
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]           97   3e-20
gi|117956391 protease, serine, 33 [Homo sapiens]                       96   4e-20
gi|223942069 enterokinase precursor [Homo sapiens]                     96   8e-20
gi|40254871 transmembrane protease, serine 11E [Homo sapiens]          96   8e-20
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]           96   8e-20
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]        96   8e-20
gi|4505881 plasminogen [Homo sapiens]                                  95   1e-19

>gi|4826762 haptoglobin isoform 1 preproprotein [Homo sapiens]
          Length = 406

 Score =  852 bits (2201), Expect = 0.0
 Identities = 406/406 (100%), Positives = 406/406 (100%)

Query: 1   MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT 60
           MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT
Sbjct: 1   MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT 60

Query: 61  EGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTE 120
           EGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTE
Sbjct: 61  EGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTE 120

Query: 121 GDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV 180
           GDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV
Sbjct: 121 GDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV 180

Query: 181 SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP 240
           SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP
Sbjct: 181 SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP 240

Query: 241 NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM 300
           NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM
Sbjct: 241 NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM 300

Query: 301 LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA 360
           LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA
Sbjct: 301 LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA 360

Query: 361 VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN 406
           VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN
Sbjct: 361 VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN 406


>gi|186910296 haptoglobin isoform 2 preproprotein [Homo sapiens]
          Length = 347

 Score =  669 bits (1726), Expect = 0.0
 Identities = 319/319 (100%), Positives = 319/319 (100%)

Query: 88  ADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEA 147
           ADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEA
Sbjct: 29  ADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEA 88

Query: 148 VCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLN 207
           VCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLN
Sbjct: 89  VCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLN 148

Query: 208 HSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICL 267
           HSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICL
Sbjct: 149 HSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICL 208

Query: 268 PSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSP 327
           PSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSP
Sbjct: 209 PSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSP 268

Query: 328 VGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYG 387
           VGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYG
Sbjct: 269 VGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYG 328

Query: 388 VYVKVTSIQDWVQKTIAEN 406
           VYVKVTSIQDWVQKTIAEN
Sbjct: 329 VYVKVTSIQDWVQKTIAEN 347


>gi|45580723 haptoglobin-related protein [Homo sapiens]
          Length = 348

 Score =  612 bits (1579), Expect = e-175
 Identities = 293/319 (91%), Positives = 302/319 (94%)

Query: 88  ADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEA 147
           +DD  PKPPEIA+GYVEH  RYQCKNYY+LRTEGDGVYTLN++KQWINKAVGDKLPECEA
Sbjct: 30  SDDRFPKPPEIANGYVEHLFRYQCKNYYRLRTEGDGVYTLNDKKQWINKAVGDKLPECEA 89

Query: 148 VCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLN 207
           VCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLN
Sbjct: 90  VCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLN 149

Query: 208 HSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICL 267
           HSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNY QVDIGLIKLKQKV VNERVMPICL
Sbjct: 150 HSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYHQVDIGLIKLKQKVLVNERVMPICL 209

Query: 268 PSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSP 327
           PSK+YAEVGRVGYVSGWG++ NFK TDHLKYVMLPVADQ  CI HYEGST P+ K PKSP
Sbjct: 210 PSKNYAEVGRVGYVSGWGQSDNFKLTDHLKYVMLPVADQYDCITHYEGSTCPKWKAPKSP 269

Query: 328 VGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYG 387
           VGVQPILNEHTFC GMSKYQEDTCYGDAGSAFAVHDLEEDTWYA GILSFDKSCAVAEYG
Sbjct: 270 VGVQPILNEHTFCVGMSKYQEDTCYGDAGSAFAVHDLEEDTWYAAGILSFDKSCAVAEYG 329

Query: 388 VYVKVTSIQDWVQKTIAEN 406
           VYVKVTSIQ WVQKTIAEN
Sbjct: 330 VYVKVTSIQHWVQKTIAEN 348


>gi|66347875 complement component 1, r subcomponent [Homo sapiens]
          Length = 705

 Score =  182 bits (461), Expect = 6e-46
 Identities = 115/358 (32%), Positives = 176/358 (49%), Gaps = 57/358 (15%)

Query: 83  LPECEADDGCPKPPEIAHGYVEHS-----------VRYQCKN-YYKLRTEG------DGV 124
           +P C+  D C +P  + +G   ++           ++Y C   YYK++T         GV
Sbjct: 368 MPRCKIKD-CGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGV 426

Query: 125 YTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHN 184
           YT   +  W N+  G+K+P C  VCGKP NP    QRI+GG     G+FPWQ     H  
Sbjct: 427 YTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGR 486

Query: 185 LTTGATLINEQWLLTTAKNLF-LNHSENATAKDIAPTLTLYVGKKQLVE--------IEK 235
              G  L+ ++W+LT A  L+   H   + A     +L +++G   + E        I +
Sbjct: 487 --GGGALLGDRWILTAAHTLYPKEHEAQSNA-----SLDVFLGHTNVEELMKLGNHPIRR 539

Query: 236 VVLHPNYSQ-------VDIGLIKLKQKVSVNERVMPICLPSKD-YAEVGRVGYVSGWGRN 287
           V +HP+Y Q        DI L++L+  V++   ++PICLP  D + ++G +GYVSG+G  
Sbjct: 540 VSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVM 599

Query: 288 ANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQ 347
              K    L++V LPVA+   C     G    +            + +++ FCAG    +
Sbjct: 600 EE-KIAHDLRFVRLPVANPQACENWLRGKNRMD------------VFSQNMFCAGHPSLK 646

Query: 348 EDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAE 405
           +D C GD+G  FAV D   D W ATGI+S+   C+   YG Y KV +  DW++K + E
Sbjct: 647 QDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCS-RGYGFYTKVLNYVDWIKKEMEE 703



 Score = 34.3 bits (77), Expect = 0.21
 Identities = 19/56 (33%), Positives = 27/56 (48%), Gaps = 7/56 (12%)

Query: 48  VRYQCKN-YYKLRTEG------DGVYTLNDKKQWINKAVGDKLPECEADDGCPKPP 96
           ++Y C   YYK++T         GVYT   +  W N+  G+K+P C    G P  P
Sbjct: 402 IQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNP 457


>gi|4502495 complement component 1, s subcomponent precursor [Homo
           sapiens]
          Length = 688

 Score =  166 bits (419), Expect = 5e-41
 Identities = 119/365 (32%), Positives = 168/365 (46%), Gaps = 47/365 (12%)

Query: 67  TLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHS--------VRYQCKN-YYKL 117
           T     +W N  +     +C+  D C  P  I +G VE          +RY C+  YY +
Sbjct: 340 TCQSNGKWSNSKL-----KCQPVD-CGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYM 393

Query: 118 RTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQA 177
              G G Y       W+N+ +G +LP+C  VCG P+ P    QRI+GG      +FPWQ 
Sbjct: 394 ENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQ- 452

Query: 178 KMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVV 237
             V   N   G  LINE W+LT A ++   + E           T  + K +++  E V 
Sbjct: 453 --VFFDNPWAGGALINEYWVLTAA-HVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVF 509

Query: 238 LHPNYSQV-----------DIGLIKLKQKVSVNERVMPICLP--SKDYAEV-GRVGYVSG 283
           +HP +  +           DI L++LK  V +   V PICLP  S DY  + G +G +SG
Sbjct: 510 IHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISG 569

Query: 284 WGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQP-ILNEHTFCAG 342
           WGR         LK   LPVA   +C          E K  K     +  +   +  CAG
Sbjct: 570 WGRTEKRDRAVRLKAARLPVAPLRKC---------KEVKVEKPTADAEAYVFTPNMICAG 620

Query: 343 MSKYQEDTCYGDAGSAFAVHDLEEDT-WYATGILSFDKSCAVAEYGVYVKVTSIQDWVQK 401
             K   D+C GD+G AFAV D  + T +YA G++S+   C    YG+Y +V +  DW+ K
Sbjct: 621 GEKGM-DSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGT--YGLYTRVKNYVDWIMK 677

Query: 402 TIAEN 406
           T+ EN
Sbjct: 678 TMQEN 682



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 23/73 (31%), Positives = 33/73 (45%), Gaps = 9/73 (12%)

Query: 33  CPKPPEIAHGYVEHS--------VRYQCKN-YYKLRTEGDGVYTLNDKKQWINKAVGDKL 83
           C  P  I +G VE          +RY C+  YY +   G G Y       W+N+ +G +L
Sbjct: 359 CGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPEL 418

Query: 84  PECEADDGCPKPP 96
           P+C    G P+ P
Sbjct: 419 PKCVPVCGVPREP 431


>gi|41393602 complement component 1, s subcomponent precursor [Homo
           sapiens]
          Length = 688

 Score =  166 bits (419), Expect = 5e-41
 Identities = 119/365 (32%), Positives = 168/365 (46%), Gaps = 47/365 (12%)

Query: 67  TLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHS--------VRYQCKN-YYKL 117
           T     +W N  +     +C+  D C  P  I +G VE          +RY C+  YY +
Sbjct: 340 TCQSNGKWSNSKL-----KCQPVD-CGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYM 393

Query: 118 RTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQA 177
              G G Y       W+N+ +G +LP+C  VCG P+ P    QRI+GG      +FPWQ 
Sbjct: 394 ENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQ- 452

Query: 178 KMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVV 237
             V   N   G  LINE W+LT A ++   + E           T  + K +++  E V 
Sbjct: 453 --VFFDNPWAGGALINEYWVLTAA-HVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVF 509

Query: 238 LHPNYSQV-----------DIGLIKLKQKVSVNERVMPICLP--SKDYAEV-GRVGYVSG 283
           +HP +  +           DI L++LK  V +   V PICLP  S DY  + G +G +SG
Sbjct: 510 IHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISG 569

Query: 284 WGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQP-ILNEHTFCAG 342
           WGR         LK   LPVA   +C          E K  K     +  +   +  CAG
Sbjct: 570 WGRTEKRDRAVRLKAARLPVAPLRKC---------KEVKVEKPTADAEAYVFTPNMICAG 620

Query: 343 MSKYQEDTCYGDAGSAFAVHDLEEDT-WYATGILSFDKSCAVAEYGVYVKVTSIQDWVQK 401
             K   D+C GD+G AFAV D  + T +YA G++S+   C    YG+Y +V +  DW+ K
Sbjct: 621 GEKGM-DSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGT--YGLYTRVKNYVDWIMK 677

Query: 402 TIAEN 406
           T+ EN
Sbjct: 678 TMQEN 682



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 23/73 (31%), Positives = 33/73 (45%), Gaps = 9/73 (12%)

Query: 33  CPKPPEIAHGYVEHS--------VRYQCKN-YYKLRTEGDGVYTLNDKKQWINKAVGDKL 83
           C  P  I +G VE          +RY C+  YY +   G G Y       W+N+ +G +L
Sbjct: 359 CGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPEL 418

Query: 84  PECEADDGCPKPP 96
           P+C    G P+ P
Sbjct: 419 PKCVPVCGVPREP 431


>gi|21264357 mannan-binding lectin serine protease 1 isoform 1
           precursor [Homo sapiens]
          Length = 699

 Score =  159 bits (403), Expect = 3e-39
 Identities = 122/417 (29%), Positives = 187/417 (44%), Gaps = 64/417 (15%)

Query: 29  ADDGCPKPPEIAHGYVEHSVRYQCKNYYK---LRTEGDGVYTLNDKKQWINKAV------ 79
           A + CP+     HG +E S   Q K ++K   L +   G   L D  +     +      
Sbjct: 297 AGNECPELQPPVHGKIEPS---QAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDG 353

Query: 80  --GDKLPECEADDGCPKPPEIAHGYVEHSVR-----------YQCKN-YYKLRTEGDGVY 125
              +K+P C+  D C  P E+ HG +  S R           Y C+  YYK+     G+Y
Sbjct: 354 TWSNKIPTCKIVD-CRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIY 412

Query: 126 TLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHN- 184
           T + +  W+NK +G  LP C  VCG PK     + RI  G    KG+ PW A M+SH N 
Sbjct: 413 TCSAQGVWMNKVLGRSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIA-MLSHLNG 471

Query: 185 -LTTGATLINEQWLLTTAKNLFLN-HSENATAKD---IAPT-LTLYVGK---------KQ 229
               G +L+   W++T A  L  +   E+ T +D   ++P+   + +GK         +Q
Sbjct: 472 QPFCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQ 531

Query: 230 LVEIEKVVLHPNYS----QVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWG 285
            + ++   LHP Y     + D+ L++L +   +N  VMPICLP     E G +  VSGWG
Sbjct: 532 HLGVKHTTLHPQYDPNTFENDVALVELLESPVLNAFVMPICLPEGPQQE-GAMVIVSGWG 590

Query: 286 RNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSK 345
           +    +F + L  + +P+ D   C + Y     P KK           +     CAG  +
Sbjct: 591 KQFLQRFPETLMEIEIPIVDHSTCQKAY----APLKKK----------VTRDMICAGEKE 636

Query: 346 YQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAE-YGVYVKVTSIQDWVQK 401
             +D C GD+G      + E   WY  G +S+   C   + YGVY  +   +DW+Q+
Sbjct: 637 GGKDACAGDSGGPMVTLNRERGQWYLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQR 693


>gi|21264359 mannan-binding lectin serine protease 1 isoform 2
           precursor [Homo sapiens]
          Length = 728

 Score =  159 bits (402), Expect = 4e-39
 Identities = 125/431 (29%), Positives = 190/431 (44%), Gaps = 76/431 (17%)

Query: 29  ADDGCPKPPEIAHGYVEHSVRYQCKNYYK---LRTEGDGVYTLNDKKQWINKAV------ 79
           A + CP+     HG +E S   Q K ++K   L +   G   L D  +     +      
Sbjct: 297 AGNECPELQPPVHGKIEPS---QAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDG 353

Query: 80  --GDKLPECEADDGCPKPPEIAHGYVEHSVR-----------YQCKN-YYKLRTEGDGVY 125
              +K+P C+  D C  P E+ HG +  S R           Y C+  YYK+     G+Y
Sbjct: 354 TWSNKIPTCKIVD-CRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIY 412

Query: 126 TLNNEKQWINKAVGDKLPECEAVCGKP-KNPANPVQRILGGHLDAKGSFPWQAKMVSHHN 184
           T + +  W+NK +G  LP C   CG+P ++  + V+RI+GG     G FPWQA +V    
Sbjct: 413 TCSAQGVWMNKVLGRSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDT 472

Query: 185 LTT-------GATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVE----- 232
                        L++  W+LT A  L     +          +T+Y+G   + +     
Sbjct: 473 SRVPNDKWFGSGALLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAV 532

Query: 233 ---IEKVVLHPNYS----QVDIGLIKLKQKVSVNERVMPICLP--SKDYAEVGRVGYVSG 283
                +VVLHP+++      DI L++L++ V +   VMP+CLP    +      +G V+G
Sbjct: 533 NSSAARVVLHPDFNIQNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGPAPHMLGLVAG 592

Query: 284 WG-RNANFK-----------FTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQ 331
           WG  N N              +D L+YV LPV    +C   YE  +     T        
Sbjct: 593 WGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVT-------- 644

Query: 332 PILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSF--DKSCAVAE-YGV 388
               E+ FCAG  +  +DTC GD+G AF + D     W   G++S+   + C   + YGV
Sbjct: 645 ----ENMFCAGYYEGGKDTCLGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGV 700

Query: 389 YVKVTSIQDWV 399
           Y KV++  DWV
Sbjct: 701 YTKVSNYVDWV 711


>gi|21264363 mannan-binding lectin serine protease 2 isoform 1
           precursor [Homo sapiens]
          Length = 686

 Score =  144 bits (363), Expect = 1e-34
 Identities = 100/345 (28%), Positives = 147/345 (42%), Gaps = 39/345 (11%)

Query: 83  LPECEADDGCPKPPEIAHGYVEHS-----------VRYQCKNYYKLRTEGDGVYTLNNEK 131
           +P C   D C  P ++  G VE+            ++Y C+  +      DG Y    + 
Sbjct: 358 MPACSIVD-CGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADG 416

Query: 132 QWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATL 191
            W +      LP CE VCG          RI GG     G FPWQ  ++     T    L
Sbjct: 417 FWTSSKGEKSLPVCEPVCGLSARTTGG--RIYGGQKAKPGDFPWQVLILG--GTTAAGAL 472

Query: 192 INEQWLLTTAKNLFLNHSENATAKDIAP-TLTLYVGKKQLVEIEKVVLHPNYSQV----- 245
           + + W+LT A  ++     +A+A DI   TL            E V +H  Y+       
Sbjct: 473 LYDNWVLTAAHAVY-EQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDN 531

Query: 246 DIGLIKLKQKVSVNERVMPICLPSKD---YAEVGRVGYVSGWGRNANFKFTDHLKYVMLP 302
           DI LIKL  KV +N  + PICLP K+   +     +G  SGWG         +L YV +P
Sbjct: 532 DIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIP 591

Query: 303 VADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVH 362
           + D  +C   YE    P              +  +  CAG+    +D+C GD+G A    
Sbjct: 592 IVDHQKCTAAYEKPPYPRGS-----------VTANMLCAGLESGGKDSCRGDSGGALVFL 640

Query: 363 DLEEDTWYATGILSF-DKSCAVA-EYGVYVKVTSIQDWVQKTIAE 405
           D E + W+  GI+S+   +C  A +YGVY KV +   W++  I++
Sbjct: 641 DSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENIISD 685


>gi|7706083 complement component 1, r subcomponent-like precursor
           [Homo sapiens]
          Length = 487

 Score =  136 bits (342), Expect = 4e-32
 Identities = 89/310 (28%), Positives = 142/310 (45%), Gaps = 36/310 (11%)

Query: 107 VRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGH 166
           V+  C+  Y  +    G  T      W ++  G+++ +C  VCG+P  P    Q  LG  
Sbjct: 191 VQNHCQEPY-YQAAAAGALTCATPGTWKDRQDGEEVLQCMPVCGRPVTPIAQNQTTLGSS 249

Query: 167 LDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVG 226
               G+FPWQA    H     G  L+ ++W+LT A  ++   S +        ++ +++G
Sbjct: 250 RAKLGNFPWQAFTSIHGR--GGGALLGDRWILTAAHTVYPKDSVSLRKNQ---SVNVFLG 304

Query: 227 KKQLVE--------IEKVVLHPNYSQV-------DIGLIKLKQKVSVNERVMPICLPSKD 271
              + E        + +VV+HP+Y Q        DI L++L+  + +   V+P+CLP  +
Sbjct: 305 HTAIDEMLKLGNHPVHRVVVHPDYRQNESHNFSGDIALLELQHSIPLGPNVLPVCLPDNE 364

Query: 272 YA-EVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGV 330
                G +GYVSG+G    +  T  LKY  LPVA ++ C    +    PE          
Sbjct: 365 TLYRSGLLGYVSGFGMEMGW-LTTELKYSRLPVAPREACNAWLQKRQRPE---------- 413

Query: 331 QPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYV 390
             + +++ FC G    +   C GD+GS + V D     W ATGI+S+   C    Y  Y 
Sbjct: 414 --VFSDNMFCVGDETQRHSVCQGDSGSVYVVWDNHAHHWVATGIVSWGIGCGEG-YDFYT 470

Query: 391 KVTSIQDWVQ 400
           KV S  DW++
Sbjct: 471 KVLSYVDWIK 480


>gi|10518503 coagulation factor VII isoform b precursor [Homo
           sapiens]
          Length = 444

 Score =  122 bits (307), Expect = 4e-28
 Identities = 85/275 (30%), Positives = 133/275 (48%), Gaps = 30/275 (10%)

Query: 143 PECEAVCGK-----PKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWL 197
           P  E  CGK      +N + P  RI+GG +  KG  PWQ  ++ +     G TLIN  W+
Sbjct: 167 PTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWV 226

Query: 198 LTTAKNL-FLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNY----SQVDIGLIKL 252
           ++ A     + +  N  A      L+ + G +Q   + +V++   Y    +  DI L++L
Sbjct: 227 VSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRL 286

Query: 253 KQKVSVNERVMPICLPSKDYAE----VGRVGYVSGWGRNANFKFTD-HLKYVMLPVADQD 307
            Q V + + V+P+CLP + ++E      R   VSGWG+  +   T   L  + +P     
Sbjct: 287 HQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQ 346

Query: 308 QCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEED 367
            C++                VG  P + E+ FCAG S   +D+C GD+G   A H     
Sbjct: 347 DCLQQ------------SRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATH--YRG 392

Query: 368 TWYATGILSFDKSCA-VAEYGVYVKVTSIQDWVQK 401
           TWY TGI+S+ + CA V  +GVY +V+   +W+QK
Sbjct: 393 TWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQK 427


>gi|4503645 coagulation factor VII isoform a precursor [Homo
           sapiens]
          Length = 466

 Score =  122 bits (307), Expect = 4e-28
 Identities = 85/275 (30%), Positives = 133/275 (48%), Gaps = 30/275 (10%)

Query: 143 PECEAVCGK-----PKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWL 197
           P  E  CGK      +N + P  RI+GG +  KG  PWQ  ++ +     G TLIN  W+
Sbjct: 189 PTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWV 248

Query: 198 LTTAKNL-FLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNY----SQVDIGLIKL 252
           ++ A     + +  N  A      L+ + G +Q   + +V++   Y    +  DI L++L
Sbjct: 249 VSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRL 308

Query: 253 KQKVSVNERVMPICLPSKDYAE----VGRVGYVSGWGRNANFKFTD-HLKYVMLPVADQD 307
            Q V + + V+P+CLP + ++E      R   VSGWG+  +   T   L  + +P     
Sbjct: 309 HQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQ 368

Query: 308 QCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEED 367
            C++                VG  P + E+ FCAG S   +D+C GD+G   A H     
Sbjct: 369 DCLQQ------------SRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATH--YRG 414

Query: 368 TWYATGILSFDKSCA-VAEYGVYVKVTSIQDWVQK 401
           TWY TGI+S+ + CA V  +GVY +V+   +W+QK
Sbjct: 415 TWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQK 449


>gi|148806900 epidermis-specific serine protease-like protein [Homo
           sapiens]
          Length = 328

 Score =  119 bits (299), Expect = 4e-27
 Identities = 77/275 (28%), Positives = 136/275 (49%), Gaps = 41/275 (14%)

Query: 147 AVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFL 206
           +VCG+P   +    R++GG   A G +PWQ  +   HN   G +L++E+ +LT A     
Sbjct: 17  SVCGQPVYSS----RVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAA----- 67

Query: 207 NHSENATAKDIAPTL---TLYVG---KKQLVEIEKVVLHPNY--SQVDIGLIKLKQKVSV 258
            H    T    + T+   ++ VG   K+    + K+V+HP Y  +  D+ L+KL  +V+ 
Sbjct: 68  -HCIQPTWTTFSYTVWLGSITVGDSRKRVKYYVSKIVIHPKYQDTTADVALLKLSSQVTF 126

Query: 259 NERVMPICLPS-KDYAEVGRVGYVSGWGR---NANFKFTDHLKYVMLPVADQDQCIRHYE 314
              ++PICLPS      +    +V+GWG+   +++  +   L+   +P+ D+  C + Y 
Sbjct: 127 TSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLY- 185

Query: 315 GSTVPEKKTPKSPVGV-----QPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTW 369
                      +P+G+     +P++ E   CAG ++  +D+C GD+G   + H   +  W
Sbjct: 186 -----------NPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCH--IDGVW 232

Query: 370 YATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIA 404
             TG++S+   C  +  GVY  V   Q W+  TI+
Sbjct: 233 IQTGVVSWGLECGKSLPGVYTNVIYYQKWINATIS 267


>gi|4503625 coagulation factor X preproprotein [Homo sapiens]
          Length = 488

 Score =  112 bits (281), Expect = 5e-25
 Identities = 75/264 (28%), Positives = 129/264 (48%), Gaps = 32/264 (12%)

Query: 151 KPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLT-TGATLINEQWLLTTAKNLFLNHS 209
           +P+   N + RI+GG     G  PWQA +++  N    G T+++E ++LT A  L+    
Sbjct: 224 QPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKR 283

Query: 210 ENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQ----VDIGLIKLKQKVSVNERVMPI 265
                 D         G + + E+E V+ H  +++     DI +++LK  ++    V P 
Sbjct: 284 FKVRVGD--RNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPA 341

Query: 266 CLPSKDYAE----VGRVGYVSGWGR-NANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPE 320
           CLP +D+AE      + G VSG+GR +   + +  LK + +P  D++ C           
Sbjct: 342 CLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSC----------- 390

Query: 321 KKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKS 380
                  +    I+ ++ FCAG    QED C GD+G         +DT++ TGI+S+ + 
Sbjct: 391 ------KLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTR--FKDTYFVTGIVSWGEG 442

Query: 381 CA-VAEYGVYVKVTSIQDWVQKTI 403
           CA   +YG+Y KVT+   W+ +++
Sbjct: 443 CARKGKYGIYTKVTAFLKWIDRSM 466


>gi|4503649 coagulation factor IX preproprotein [Homo sapiens]
          Length = 461

 Score =  106 bits (265), Expect = 3e-23
 Identities = 72/265 (27%), Positives = 124/265 (46%), Gaps = 50/265 (18%)

Query: 157 NPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKD 216
           N   R++GG     G FPWQ  +    +   G +++NE+W++T A      H      K 
Sbjct: 222 NDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAA------HCVETGVK- 274

Query: 217 IAPTLTLYVGKKQLVEIE---------KVVLHPNYSQV------DIGLIKLKQKVSVNER 261
               +T+  G+  + E E         +++ H NY+        DI L++L + + +N  
Sbjct: 275 ----ITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSY 330

Query: 262 VMPICLPSKDYAEV---GRVGYVSGWGRNAN-FKFTDHLKYVMLPVADQDQCIRHYEGST 317
           V PIC+  K+Y  +      GYVSGWGR  +  +    L+Y+ +P+ D+  C+R      
Sbjct: 331 VTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLR------ 384

Query: 318 VPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSF 377
                        +  +  + FCAG  +   D+C GD+G         E T + TGI+S+
Sbjct: 385 -----------STKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTE--VEGTSFLTGIISW 431

Query: 378 DKSCAV-AEYGVYVKVTSIQDWVQK 401
            + CA+  +YG+Y KV+   +W+++
Sbjct: 432 GEECAMKGKYGIYTKVSRYVNWIKE 456


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  105 bits (261), Expect = 1e-22
 Identities = 76/284 (26%), Positives = 131/284 (46%), Gaps = 42/284 (14%)

Query: 139 GDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLL 198
           G +  +    CG+P+     + R++GG    +G +PWQ  +  + +   G +LI EQW+L
Sbjct: 16  GSQRAKAATACGRPRM----LNRMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVL 71

Query: 199 TTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVE---------IEKVVLHPNY----SQV 245
           T A + F N SE +  +       + +G +QLV+         + +V  +P Y    S  
Sbjct: 72  TAA-HCFRNTSETSLYQ-------VLLGARQLVQPGPHAMYARVRQVESNPLYQGTASSA 123

Query: 246 DIGLIKLKQKVSVNERVMPICLPSKDYA-EVGRVGYVSGWGRNANFKFTDH---LKYVML 301
           D+ L++L+  V     ++P+CLP      E G   +V+GWG  +          L+ + +
Sbjct: 124 DVALVELEAPVPFTNYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAV 183

Query: 302 PVADQDQCIRHYEGSTVPEKKTPKSPVGVQP-ILNEHTFCAGMSKYQEDTCYGDAGSAFA 360
           P+ D  +C   Y   T           G QP  +     CAG  + ++D C GD+G    
Sbjct: 184 PIIDTPKCNLLYSKDT---------EFGYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLV 234

Query: 361 VHDLEEDTWYATGILSFDKSCAVAEY-GVYVKVTSIQDWVQKTI 403
              L   +W   G++S+ + CA     GVY++VT+  +W+ + I
Sbjct: 235 C--LVGQSWLQAGVISWGEGCARQNRPGVYIRVTAHHNWIHRII 276


>gi|4506115 protein C [Homo sapiens]
          Length = 461

 Score =  104 bits (259), Expect = 2e-22
 Identities = 75/271 (27%), Positives = 127/271 (46%), Gaps = 56/271 (20%)

Query: 161 RILGGHLDAKGSFPWQAKMV-SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAP 219
           R++ G +  +G  PWQ  ++ S   L  GA LI+  W+LT A  +           D + 
Sbjct: 211 RLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCM-----------DESK 259

Query: 220 TLTLYVGKKQL---------VEIEKVVLHPNYSQV----DIGLIKLKQKVSVNERVMPIC 266
            L + +G+  L         ++I++V +HPNYS+     DI L+ L Q  ++++ ++PIC
Sbjct: 260 KLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPIC 319

Query: 267 LPSKDYAE-----VGRVGYVSGWG------RNANFKFTDHLKYVMLPVADQDQCIRHYEG 315
           LP    AE      G+   V+GWG      + A    T  L ++ +PV   ++C      
Sbjct: 320 LPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNEC------ 373

Query: 316 STVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGIL 375
           S V           +  +++E+  CAG+   ++D C GD+G           TW+  G++
Sbjct: 374 SEV-----------MSNMVSENMLCAGILGDRQDACEGDSGGPMVAS--FHGTWFLVGLV 420

Query: 376 SFDKSCAVA-EYGVYVKVTSIQDWVQKTIAE 405
           S+ + C +   YGVY KV+   DW+   I +
Sbjct: 421 SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRD 451


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  102 bits (253), Expect = 8e-22
 Identities = 78/270 (28%), Positives = 123/270 (45%), Gaps = 26/270 (9%)

Query: 146 EAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLF 205
           EA CG       P  RI GG     G +PWQ  +        G +L++EQW+L+ A    
Sbjct: 34  EAPCG-----VAPQARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFP 88

Query: 206 LNHSENA-TAKDIAPTLTLYVGKKQLVEIEKVVLHPNY----SQVDIGLIKLKQKVSVNE 260
             H + A   K  A  L  Y    ++  ++ ++ HP+Y    SQ DI L++L + ++ + 
Sbjct: 89  SEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSR 148

Query: 261 RVMPICLPSKDYA-EVGRVGYVSGWGR---NANFKFTDHLKYVMLPVADQDQCIRHYEGS 316
            + PICLP+ + +   G    V+GWG    + +      L+ + +P+  ++ C   Y   
Sbjct: 149 YIRPICLPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNID 208

Query: 317 TVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILS 376
             PE+     P  VQ    E   CAG  +  +D C GD+G   +     E  WY TGI+S
Sbjct: 209 AKPEE-----PHFVQ----EDMVCAGYVEGGKDACQGDSGGPLSCP--VEGLWYLTGIVS 257

Query: 377 FDKSCAVAEY-GVYVKVTSIQDWVQKTIAE 405
           +  +C      GVY   +S   W+Q  + E
Sbjct: 258 WGDACGARNRPGVYTLASSYASWIQSKVTE 287


>gi|110578663 hypothetical protein LOC203074 [Homo sapiens]
          Length = 352

 Score =  101 bits (251), Expect = 1e-21
 Identities = 64/250 (25%), Positives = 111/250 (44%), Gaps = 28/250 (11%)

Query: 161 RILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPT 220
           RI GG     G FPWQ  + +      G +++N+ W+LT A  L+           +  T
Sbjct: 67  RITGGMEAEVGEFPWQVSIQARSEPFCGGSILNKWWILTAAHCLYSEELFPEELSVVLGT 126

Query: 221 LTLYVGKKQLVEIEKVVLHPNYSQV----DIGLIKLKQKVSVNERVMPICLPSKDYAEVG 276
             L     ++ E+  ++LH ++ +     DI L+ L   + +++  +PICLP++      
Sbjct: 127 NDLTSPSMEIKEVASIILHKDFKRANMDNDIALLLLASPIKLDDLKVPICLPTQPGPATW 186

Query: 277 RVGYVSGWGR----NANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQP 332
           R  +V+GWG+    + N   TD +K  M+ + D ++C + +                  P
Sbjct: 187 RECWVAGWGQTNAADKNSVKTDLMKAPMV-IMDWEECSKMF------------------P 227

Query: 333 ILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEY-GVYVK 391
            L ++  CAG      D C GD+G          + WY  GI+S+ KSC      G+Y  
Sbjct: 228 KLTKNMLCAGYKNESYDACKGDSGGPLVCTPEPGEKWYQVGIISWGKSCGEKNTPGIYTS 287

Query: 392 VTSIQDWVQK 401
           + +   W++K
Sbjct: 288 LVNYNLWIEK 297


>gi|4503635 coagulation factor II preproprotein [Homo sapiens]
          Length = 622

 Score = 99.8 bits (247), Expect = 4e-21
 Identities = 78/276 (28%), Positives = 127/276 (46%), Gaps = 54/276 (19%)

Query: 161 RILGGHLDAKGSFPWQAKMV--SHHNLTTGATLINEQWLLTTAKNL-FLNHSENATAKDI 217
           RI+ G     G  PWQ  +   S   L  GA+LI+++W+LT A  L +    +N T  D 
Sbjct: 363 RIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEND- 421

Query: 218 APTLTLYVGK----------KQLVEIEKVVLHPNYS-----QVDIGLIKLKQKVSVNERV 262
              L + +GK          +++  +EK+ +HP Y+       DI L+KLK+ V+ ++ +
Sbjct: 422 ---LLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYI 478

Query: 263 MPICLPSKDYA----EVGRVGYVSGWGR-------NANFKFTDHLKYVMLPVADQDQCIR 311
            P+CLP ++ A    + G  G V+GWG        N        L+ V LP+ ++  C  
Sbjct: 479 HPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVC-- 536

Query: 312 HYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQE---DTCYGDAGSAFAVHDLEEDT 368
                        K    ++  + ++ FCAG    +    D C GD+G  F +     + 
Sbjct: 537 -------------KDSTRIR--ITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNR 581

Query: 369 WYATGILSFDKSC-AVAEYGVYVKVTSIQDWVQKTI 403
           WY  GI+S+ + C    +YG Y  V  ++ W+QK I
Sbjct: 582 WYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI 617


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score = 99.4 bits (246), Expect = 5e-21
 Identities = 84/348 (24%), Positives = 145/348 (41%), Gaps = 62/348 (17%)

Query: 85  ECEADDGCPKPPEIAHGY---VEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVG-- 139
           +C+ D  C   P++  G    +  S   QC+          G +T   E +   K     
Sbjct: 496 QCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPC-----GTFTFQCEDRSCVKKPNPQ 550

Query: 140 -DKLPECE-------AVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATL 191
            D  P+C          CG       P  RI+GG + ++G +PWQA +        G  L
Sbjct: 551 CDGRPDCRDGSDEEHCDCGLQ----GPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGAL 606

Query: 192 INEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGK---------KQLVEIEKVVLHPNY 242
           I ++W++T A + F   S  +T        T+++GK         +   ++ +++LHP +
Sbjct: 607 IADRWVITAA-HCFQEDSMASTV-----LWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYH 660

Query: 243 SQ----VDIGLIKLKQKVSVNERVMPICLPSKD-YAEVGRVGYVSGWGR-NANFKFTDHL 296
            +     D+ L++L   V  +  V P+CLP++  + E G   +++GWG        ++ L
Sbjct: 661 EEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISNAL 720

Query: 297 KYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAG 356
           + V + +  QD C   Y     P                    CAG  K ++D C GD+G
Sbjct: 721 QKVDVQLIPQDLCSEVYRYQVTP-----------------RMLCAGYRKGKKDACQGDSG 763

Query: 357 SAFAVHDLEEDTWYATGILSFDKSCAVAEY-GVYVKVTSIQDWVQKTI 403
                  L    W+  G++S+   C    Y GVY ++T +  W+Q+ +
Sbjct: 764 GPLVCKAL-SGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQQVV 810


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score = 99.0 bits (245), Expect = 7e-21
 Identities = 74/267 (27%), Positives = 118/267 (44%), Gaps = 31/267 (11%)

Query: 141 KLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTT 200
           KL EC A     K       R++GG   A G  PWQ  +        GAT++ ++WLL+ 
Sbjct: 488 KLQECGARPAMEKPT-----RVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSA 542

Query: 201 AKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYS----QVDIGLIKLKQKV 256
           A        E   A     +L    G    + + +VVLHP Y+      D+ +++L   +
Sbjct: 543 AHCFNHTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPL 602

Query: 257 SVNERVMPICLP-SKDYAEVGRVGYVSGWG--RNANFKFTDHLKYVMLPVADQDQCIRHY 313
           + N+ + P+CLP +     VGR   +SGWG  +  N    + L+   + + DQ  C   Y
Sbjct: 603 AFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLY 662

Query: 314 EGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATG 373
             S                 L +   CAG  + + D+C GD+G   A  +     +Y  G
Sbjct: 663 NFS-----------------LTDRMICAGFLEGKVDSCQGDSGGPLACEE-APGVFYLAG 704

Query: 374 ILSFDKSCA-VAEYGVYVKVTSIQDWV 399
           I+S+   CA V + GVY ++T ++ W+
Sbjct: 705 IVSWGIGCAQVKKPGVYTRITRLKGWI 731



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 69/267 (25%), Positives = 116/267 (43%), Gaps = 34/267 (12%)

Query: 146 EAVCGKPKNPA-NPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNL 204
           EA C     PA     RI+GG   + G FPWQA +  +     GA +IN +WL++ A   
Sbjct: 186 EAHCECGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAH-- 243

Query: 205 FLNHSENATAKDIAPTLTLYVGKKQL----VEIEKVVLHPNY----SQVDIGLIKLKQKV 256
             N  ++ T K +A     Y+   +      ++ ++V HP Y    +  D+ +++L   +
Sbjct: 244 CFNEFQDPT-KWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPL 302

Query: 257 SVNERVMPICLPSKDYA-EVGRVGYVSGWG--RNANFKFTDHLKYVMLPVADQDQCIRHY 313
                + P+CLP+  +     +   +SGWG  +       + L+   + + DQ  C   Y
Sbjct: 303 PFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASLY 362

Query: 314 EGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATG 373
             S                 L +   CAG    + D+C GD+G      +     ++  G
Sbjct: 363 GHS-----------------LTDRMVCAGYLDGKVDSCQGDSGGPLVCEE-PSGRFFLAG 404

Query: 374 ILSFDKSCAVAEY-GVYVKVTSIQDWV 399
           I+S+   CA A   GVY +VT ++DW+
Sbjct: 405 IVSWGIGCAEARRPGVYARVTRLRDWI 431



 Score = 82.0 bits (201), Expect = 9e-16
 Identities = 71/273 (26%), Positives = 114/273 (41%), Gaps = 34/273 (12%)

Query: 141  KLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKM-VSHHNLTTGATLINEQWLLT 199
            +LP+C         PA  + RI+GG    +G +PWQ  + +       GA L+ E+WLL+
Sbjct: 813  QLPDCGLA------PA-ALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLS 865

Query: 200  TAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYS----QVDIGLIKLKQK 255
             A + F  + +         T  L   + QL  + ++  HP Y+      D+ L++L   
Sbjct: 866  AA-HCFDVYGDPKQWAAFLGTPFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGP 924

Query: 256  VSVNERVMPICLPSK-DYAEVGRVGYVSGWGR-NANFKFTDHLKYVMLPVADQDQCIRHY 313
            V  +  V PICLP        G    ++GWG           L+   + +  +  C R Y
Sbjct: 925  VRRSRLVRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFY 984

Query: 314  EGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATG 373
                         PV +    +    CAG  +   D+C GDAG   A  +     W  TG
Sbjct: 985  -------------PVQI----SSRMLCAGFPQGGVDSCSGDAGGPLACRE-PSGRWVLTG 1026

Query: 374  ILSFDKSCAVAEY-GVYVKVTSIQDWVQKTIAE 405
            + S+   C    + GVY +V +++ W+ + I E
Sbjct: 1027 VTSWGYGCGRPHFPGVYTRVAAVRGWIGQHIQE 1059


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 72/263 (27%), Positives = 117/263 (44%), Gaps = 44/263 (16%)

Query: 161 RILGGHLDAKGSFPWQAKMVSHHNLTT-----GATLINEQWLLTTAKNLFLNHSENATAK 215
           RI+GG    +G +PWQ  +  H    T     G ++I  QW+LT A   +        + 
Sbjct: 387 RIVGGTASVRGEWPWQVTL--HTTSPTQRHLCGGSIIGNQWILTAAHCFY-----GVESP 439

Query: 216 DIAPTLTLYVGKKQLVE------IEKVVLHPNY----SQVDIGLIKLKQKVSVNERVMPI 265
            I    +  + + ++ E      ++++++H  Y    S  DI L+KL+  V+  +   PI
Sbjct: 440 KILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPI 499

Query: 266 CLPSK-DYAEVGRVGYVSGWG-RNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKT 323
           CLPSK D   +    +V+GWG R    K  + L+   +P+   ++C + Y G  +  K  
Sbjct: 500 CLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHK-- 557

Query: 324 PKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAV 383
                           CAG  +  +D C GD+G   +      + W+  GI S+ + CA 
Sbjct: 558 --------------MICAGYREGGKDACKGDSGGPLSCK--HNEVWHLVGITSWGEGCAQ 601

Query: 384 AEY-GVYVKVTSIQDWV-QKTIA 404
            E  GVY  V    DW+ +KT A
Sbjct: 602 RERPGVYTNVVEYVDWILEKTQA 624


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 70/259 (27%), Positives = 114/259 (44%), Gaps = 46/259 (17%)

Query: 160 QRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKD-IA 218
           QRILGG    +GS+PWQ  +  ++    G +LIN  W+LT A         N+  +D IA
Sbjct: 185 QRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCF----RSNSNPRDWIA 240

Query: 219 PTLTLYVGKKQLVEIEKVVLHPNYSQV----DIGLIKLKQKVSVNERVMPICLP-SKDYA 273
            +       K  + +  +++H NY       DI L++L+  V+  + +  +CLP +    
Sbjct: 241 TSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNI 300

Query: 274 EVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPI 333
             G   YV+GWG                         + Y G TVPE +  +  +    +
Sbjct: 301 PPGSTAYVTGWG------------------------AQEYAGHTVPELRQGQVRIISNDV 336

Query: 334 LN-EHTF---------CAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAV 383
            N  H++         CAG+ +   D C GD+G      D     W+  GI+S+   C +
Sbjct: 337 CNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQED-SRRLWFIVGIVSWGDQCGL 395

Query: 384 AEY-GVYVKVTSIQDWVQK 401
            +  GVY +VT+  DW+++
Sbjct: 396 PDKPGVYTRVTAYLDWIRQ 414


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score = 96.3 bits (238), Expect = 4e-20
 Identities = 77/270 (28%), Positives = 124/270 (45%), Gaps = 28/270 (10%)

Query: 147 AVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFL 206
           A CG+P+  +    RI+GG     G +PWQA +        G +LI  QW+LT A + F 
Sbjct: 26  AACGQPRMSS----RIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAA-HCFP 80

Query: 207 NHSENATAKDIAPTLTLYVGKKQL--VEIEKVVLHPNYSQ----VDIGLIKLKQKVSVNE 260
             +  A  +     L L     +   V + +V+L P+YS+     D+ L++L++ V ++ 
Sbjct: 81  RRALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALLQLRRPVPLSA 140

Query: 261 RVMPICLPSKD-YAEVGRVGYVSGWGR---NANFKFTDHLKYVMLPVADQDQCIRHYE-G 315
           RV P+CLP        G    V+GWG             L+ V +P+ D   C   Y  G
Sbjct: 141 RVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVG 200

Query: 316 STVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGIL 375
           + VP+          + I+   + CAG  +  +D C GD+G       L+  +W   G++
Sbjct: 201 ADVPQ---------AERIVLPGSLCAGYPQGHKDACQGDSGGPLTC--LQSGSWVLVGVV 249

Query: 376 SFDKSCAVAEY-GVYVKVTSIQDWVQKTIA 404
           S+ K CA+    GVY  V +   W+Q  ++
Sbjct: 250 SWGKGCALPNRPGVYTSVATYSPWIQARVS 279


>gi|223942069 enterokinase precursor [Homo sapiens]
          Length = 1019

 Score = 95.5 bits (236), Expect = 8e-20
 Identities = 76/308 (24%), Positives = 137/308 (44%), Gaps = 51/308 (16%)

Query: 114  YYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSF 173
            + KL T  DG   L   +Q +  ++  +L      CGK     +   +I+GG    +G++
Sbjct: 738  FVKLNTAPDGHLILTPSQQCLQDSL-IRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAW 796

Query: 174  PWQAKMVSHHNLTTGATLINEQWLLTTAKNLF--------------LNHSENATAKDIAP 219
            PW   +     L  GA+L++  WL++ A  ++              L+   N T+    P
Sbjct: 797  PWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVP 856

Query: 220  TLTLYVGKKQLVEIEKVVLHPNYSQ----VDIGLIKLKQKVSVNERVMPICLPSKDYA-E 274
             L           I+++V++P+Y++     DI ++ L+ KV+  + + PICLP ++    
Sbjct: 857  RL-----------IDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFP 905

Query: 275  VGRVGYVSGWGRNANFKFTDH-LKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPI 333
             GR   ++GWG       T + L+   +P+   ++C +      +PE             
Sbjct: 906  PGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQ-----MPEYN----------- 949

Query: 334  LNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEY-GVYVKV 392
            + E+  CAG  +   D+C GD+G        E + W+  G+ SF   CA+    GVY +V
Sbjct: 950  ITENMICAGYEEGGIDSCQGDSGGPLMCQ--ENNRWFLAGVTSFGYKCALPNRPGVYARV 1007

Query: 393  TSIQDWVQ 400
            +   +W+Q
Sbjct: 1008 SRFTEWIQ 1015


>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
          Length = 423

 Score = 95.5 bits (236), Expect = 8e-20
 Identities = 68/246 (27%), Positives = 105/246 (42%), Gaps = 26/246 (10%)

Query: 161 RILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPT 220
           RI+GG    +G +PWQA +    +   GATLIN  WL++ A       +          T
Sbjct: 191 RIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNPARWTASFGVT 250

Query: 221 LTLYVGKKQLVEIEKVVLHPNYSQ----VDIGLIKLKQKVSVNERVMPICLPSKDYA-EV 275
           +     K+ L    ++++H  Y       DI L +L   V     V  +CLP   Y  + 
Sbjct: 251 IKPSKMKRGL---RRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASYEFQP 307

Query: 276 GRVGYVSGWGRNANFKFT-DHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPIL 334
           G V +V+G+G   N  ++ +HL+   + + D   C                 P      +
Sbjct: 308 GDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTC---------------NEPQAYNDAI 352

Query: 335 NEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEY-GVYVKVT 393
                CAG  + + D C GD+G      D   D WY  GI+S+   CA     GVY +VT
Sbjct: 353 TPRMLCAGSLEGKTDACQGDSGGPLVSSDAR-DIWYLAGIVSWGDECAKPNKPGVYTRVT 411

Query: 394 SIQDWV 399
           +++DW+
Sbjct: 412 ALRDWI 417


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score = 95.5 bits (236), Expect = 8e-20
 Identities = 68/258 (26%), Positives = 117/258 (45%), Gaps = 31/258 (12%)

Query: 161 RILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPT 220
           RI+GG   A G +PWQA +      T G +++  +W++T A  +        ++  +   
Sbjct: 217 RIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAG 276

Query: 221 LTLY--VGKKQLVEIEKVVLHPNYS----QVDIGLIKLKQKVSVNERVMPICLPSKD-YA 273
           L  +  V   Q   +E+++ HP YS      D+ L++L+  ++ ++ V  +CLP+K+ + 
Sbjct: 277 LVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHF 336

Query: 274 EVGRVGYVSGWGRN--ANFKFTDHLKYVMLPVADQDQCIRH--YEGSTVPEKKTPKSPVG 329
             G   +VSGWG    ++   +D L+  ++P+     C     Y G+  P          
Sbjct: 337 PKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTP---------- 386

Query: 330 VQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEY-GV 388
                     CAG    + D C GD+G      D   DTW   G++S+ + CA   + GV
Sbjct: 387 -------RMLCAGYLDGRADACQGDSGGPLVCPD--GDTWRLVGVVSWGRGCAEPNHPGV 437

Query: 389 YVKVTSIQDWVQKTIAEN 406
           Y KV    DW+  T  ++
Sbjct: 438 YAKVAEFLDWIHDTAQDS 455


>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
          Length = 423

 Score = 95.5 bits (236), Expect = 8e-20
 Identities = 68/246 (27%), Positives = 105/246 (42%), Gaps = 26/246 (10%)

Query: 161 RILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPT 220
           RI+GG    +G +PWQA +    +   GATLIN  WL++ A       +          T
Sbjct: 191 RIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNPARWTASFGVT 250

Query: 221 LTLYVGKKQLVEIEKVVLHPNYSQ----VDIGLIKLKQKVSVNERVMPICLPSKDYA-EV 275
           +     K+ L    ++++H  Y       DI L +L   V     V  +CLP   Y  + 
Sbjct: 251 IKPSKMKRGL---RRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASYEFQP 307

Query: 276 GRVGYVSGWGRNANFKFT-DHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPIL 334
           G V +V+G+G   N  ++ +HL+   + + D   C                 P      +
Sbjct: 308 GDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTC---------------NEPQAYNDAI 352

Query: 335 NEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEY-GVYVKVT 393
                CAG  + + D C GD+G      D   D WY  GI+S+   CA     GVY +VT
Sbjct: 353 TPRMLCAGSLEGKTDACQGDSGGPLVSSDAR-DIWYLAGIVSWGDECAKPNKPGVYTRVT 411

Query: 394 SIQDWV 399
           +++DW+
Sbjct: 412 ALRDWI 417


>gi|4505881 plasminogen [Homo sapiens]
          Length = 810

 Score = 94.7 bits (234), Expect = 1e-19
 Identities = 77/275 (28%), Positives = 123/275 (44%), Gaps = 31/275 (11%)

Query: 142 LPECEAV---CGKPK-NPANPVQRILGGHLDAKGSFPWQAKMVSHHNLT-TGATLINEQW 196
           +P+C A    CGKP+  P     R++GG +    S+PWQ  + +   +   G TLI+ +W
Sbjct: 557 VPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEW 616

Query: 197 LLTTAKNLFLNHSENATAKDIAPTLTLYVGKK---QLVEIEKVVLHPNYSQVDIGLIKLK 253
           +LT A    L  S   ++  +       V  +   Q +E+ ++ L P  ++ DI L+KL 
Sbjct: 617 VLTAAH--CLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEP--TRKDIALLKLS 672

Query: 254 QKVSVNERVMPICLPSKDYAEVGRVG-YVSGWGRNANFKFTDHLKYVMLPVADQDQCIRH 312
               + ++V+P CLPS +Y    R   +++GWG          LK   LPV +   C R 
Sbjct: 673 SPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQLPVIENKVCNR- 731

Query: 313 YEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYAT 372
           YE      + T                CAG      D+C GD+G        E+D +   
Sbjct: 732 YEFLNGRVQST--------------ELCAGHLAGGTDSCQGDSGGPLVC--FEKDKYILQ 775

Query: 373 GILSFDKSCA-VAEYGVYVKVTSIQDWVQKTIAEN 406
           G+ S+   CA   + GVYV+V+    W++  +  N
Sbjct: 776 GVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN 810


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.134    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,122,098
Number of Sequences: 37866
Number of extensions: 831524
Number of successful extensions: 2249
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 112
Number of HSP's successfully gapped in prelim test: 88
Number of HSP's that attempted gapping in prelim test: 1746
Number of HSP's gapped (non-prelim): 278
length of query: 406
length of database: 18,247,518
effective HSP length: 105
effective length of query: 301
effective length of database: 14,271,588
effective search space: 4295747988
effective search space used: 4295747988
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.