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Search of human proteins with 48255924
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|48255924 NADH-ubiquinone oxidoreductase flavoprotein 3
isoform a precursor [Homo sapiens]
(473 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|48255924 NADH-ubiquinone oxidoreductase flavoprotein 3 isofor... 939 0.0
gi|48255926 NADH-ubiquinone oxidoreductase flavoprotein 3 isofor... 114 2e-25
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 61 3e-09
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 50 3e-06
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 50 4e-06
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ... 49 8e-06
gi|68348716 AF4/FMR2 family, member 3 isoform 2 [Homo sapiens] 49 8e-06
gi|68348714 AF4/FMR2 family, member 3 isoform 1 [Homo sapiens] 49 8e-06
gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens] 49 8e-06
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 47 3e-05
gi|150170670 piccolo isoform 2 [Homo sapiens] 47 4e-05
gi|150378539 piccolo isoform 1 [Homo sapiens] 47 4e-05
gi|110349719 titin isoform N2-A [Homo sapiens] 47 5e-05
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 47 5e-05
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 47 5e-05
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 47 5e-05
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 46 6e-05
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 46 6e-05
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 46 6e-05
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 46 6e-05
gi|51317366 myosin XVIIIB [Homo sapiens] 46 8e-05
gi|224451082 cytospin A [Homo sapiens] 45 1e-04
gi|224451080 cytospin A [Homo sapiens] 45 1e-04
gi|27734775 hypothetical protein LOC286499 [Homo sapiens] 45 1e-04
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens] 45 2e-04
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens] 45 2e-04
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens] 45 2e-04
gi|104526627 triadin [Homo sapiens] 45 2e-04
gi|150418009 transforming, acidic coiled-coil containing protein... 44 2e-04
gi|15559211 RE1-silencing transcription factor [Homo sapiens] 44 3e-04
>gi|48255924 NADH-ubiquinone oxidoreductase flavoprotein 3 isoform a
precursor [Homo sapiens]
Length = 473
Score = 939 bits (2426), Expect = 0.0
Identities = 473/473 (100%), Positives = 473/473 (100%)
Query: 1 MAAPCLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSKKQSPPKNVVE 60
MAAPCLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSKKQSPPKNVVE
Sbjct: 1 MAAPCLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSKKQSPPKNVVE 60
Query: 61 PKERGKLLATQTAAELSKNLSSPSSYPPAVNKGRKVASPSPSGSVLFTDEGVPKFLSRKT 120
PKERGKLLATQTAAELSKNLSSPSSYPPAVNKGRKVASPSPSGSVLFTDEGVPKFLSRKT
Sbjct: 61 PKERGKLLATQTAAELSKNLSSPSSYPPAVNKGRKVASPSPSGSVLFTDEGVPKFLSRKT 120
Query: 121 LVEFPQKVLSPFRKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSK 180
LVEFPQKVLSPFRKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSK
Sbjct: 121 LVEFPQKVLSPFRKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSK 180
Query: 181 GRGGLRKPEASHSFENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGR 240
GRGGLRKPEASHSFENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGR
Sbjct: 181 GRGGLRKPEASHSFENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGR 240
Query: 241 ENARPKTTMPRSQVDEEFLKQSLKEKQLQKTFRLNEIDKESQKPFEVKGPLPVHTKSGLS 300
ENARPKTTMPRSQVDEEFLKQSLKEKQLQKTFRLNEIDKESQKPFEVKGPLPVHTKSGLS
Sbjct: 241 ENARPKTTMPRSQVDEEFLKQSLKEKQLQKTFRLNEIDKESQKPFEVKGPLPVHTKSGLS 300
Query: 301 APPKGSPAPAVLAEEARAEGQLQASPPGAAEGHLEKPVPEPQRKAAPPLPRKETSGTQGI 360
APPKGSPAPAVLAEEARAEGQLQASPPGAAEGHLEKPVPEPQRKAAPPLPRKETSGTQGI
Sbjct: 301 APPKGSPAPAVLAEEARAEGQLQASPPGAAEGHLEKPVPEPQRKAAPPLPRKETSGTQGI 360
Query: 361 EGHLKGGQAIVEDQIPPSNLETVPVENNHGFHEKTAALKLEAEGEAMEDAAAPGDDRGGT 420
EGHLKGGQAIVEDQIPPSNLETVPVENNHGFHEKTAALKLEAEGEAMEDAAAPGDDRGGT
Sbjct: 361 EGHLKGGQAIVEDQIPPSNLETVPVENNHGFHEKTAALKLEAEGEAMEDAAAPGDDRGGT 420
Query: 421 QEPAPVPAEPFDNTTYKNLQHHDYSTYTFLDLNLELSKFRMPQPSSGRESPRH 473
QEPAPVPAEPFDNTTYKNLQHHDYSTYTFLDLNLELSKFRMPQPSSGRESPRH
Sbjct: 421 QEPAPVPAEPFDNTTYKNLQHHDYSTYTFLDLNLELSKFRMPQPSSGRESPRH 473
>gi|48255926 NADH-ubiquinone oxidoreductase flavoprotein 3 isoform b
precursor [Homo sapiens]
Length = 108
Score = 114 bits (285), Expect = 2e-25
Identities = 56/84 (66%), Positives = 64/84 (76%), Gaps = 1/84 (1%)
Query: 391 FHEKTAALKLEAE-GEAMEDAAAPGDDRGGTQEPAPVPAEPFDNTTYKNLQHHDYSTYTF 449
F + + L AE G++ + + ++PAPVPAEPFDNTTYKNLQHHDYSTYTF
Sbjct: 25 FRGLASTVSLSAESGKSEKGQPQNSKKQSPPKKPAPVPAEPFDNTTYKNLQHHDYSTYTF 84
Query: 450 LDLNLELSKFRMPQPSSGRESPRH 473
LDLNLELSKFRMPQPSSGRESPRH
Sbjct: 85 LDLNLELSKFRMPQPSSGRESPRH 108
Score = 111 bits (277), Expect = 2e-24
Identities = 56/56 (100%), Positives = 56/56 (100%)
Query: 1 MAAPCLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSKKQSPPK 56
MAAPCLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSKKQSPPK
Sbjct: 1 MAAPCLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSKKQSPPK 56
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 60.8 bits (146), Expect = 3e-09
Identities = 79/390 (20%), Positives = 158/390 (40%), Gaps = 28/390 (7%)
Query: 40 KSEKGQPQNSKKQSPPKNVVEPKERGK--LLATQTAAELSKNLSSPSSYPPAVNKG---R 94
K E P+ +K SP K + E+ K + A + E +K+ + P K
Sbjct: 643 KEEAKSPEKAK--SPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKE 700
Query: 95 KVASPSPSGSVLFTDEGVPKFLSR--KTLVEFPQKVLSPFRKQGSDSEARQVGRKVTSPS 152
+ SP + S + + P+ K + P+K SP +++ E + K +
Sbjct: 701 EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLD 760
Query: 153 SSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHS---FENRAPRVTVSAKEKT 209
S + + ++ + + + + S + ++ PE + S + +AP + KE+
Sbjct: 761 VKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEE- 819
Query: 210 LLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKTTMPRSQVDEEFLKQSLKEKQLQ 269
++ P + + EKP + K K P K E + A PKT + EE K+ + +++
Sbjct: 820 -VKSP---VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVE 875
Query: 270 KTFRLNEIDKESQKPFEVKGPLPVHTKSGLSAPPKGSPAPAVLAEEARAEGQLQASPPGA 329
+ + ++K + E K K + P K +PA + E+A+ + + + +
Sbjct: 876 EK-KEPAVEKPKESKVEAKKE-EAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEP 933
Query: 330 AEGHLEKPVPEPQRKAAPPLPR--KETSGTQGIEGHLKGGQAIVEDQI---PPSNLETVP 384
+ ++P ++K A P + KE + E +A +D+ PS +
Sbjct: 934 DDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEK 993
Query: 385 VENNHGFHEKTAALKLEAEGEAMEDAAAPG 414
E + +K + + +A ED AA G
Sbjct: 994 AEKSSSTDQKDS----KPPEKATEDKAAKG 1019
Score = 48.1 bits (113), Expect = 2e-05
Identities = 58/286 (20%), Positives = 108/286 (37%), Gaps = 12/286 (4%)
Query: 147 KVTSPSSSSSSSSSDSES---DDEADVSEVTPRVVSKGRGGLRKPEASHSFENRAPRVTV 203
KV S S+ E+ +++ + ++VT V + ++ E E
Sbjct: 437 KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKE--EEGGEEEEA 494
Query: 204 SAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKTTMPRSQVDEEFLKQSL 263
E+ P + PEK + K P+E + + + P E K
Sbjct: 495 EGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPA 554
Query: 264 KEKQLQKTFRLNEIDKESQKPFEVKGPLPVHTKSGLSAPPKGSPAPAVLAEEARAEGQLQ 323
KE+ + +E++ P EVK P + + A SPA A E+A++ + +
Sbjct: 555 KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK---SPAEAKSPEKAKSPVKEE 611
Query: 324 ASPPGAAEGHLEKPVPEPQRKAAPPLPRKETSGTQGIEGHLKGGQAIVEDQIPPSNLETV 383
A P A+ +++ P +P + T + + K E+ P ++
Sbjct: 612 AKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTK--EEAKSPEKAKSPEKEEAKSPEKAKS- 668
Query: 384 PVENNHGFHEKTAALKLEAEGEAMEDAAAPGDDRGGTQEPAPVPAE 429
PV+ EK A ++AE ++ E A +P + + E A P +
Sbjct: 669 PVKAEAKSPEK-AKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVK 713
Score = 36.2 bits (82), Expect = 0.066
Identities = 39/209 (18%), Positives = 75/209 (35%), Gaps = 14/209 (6%)
Query: 37 ESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPSSYPPAVNKGRKV 96
+S E+ +PQ K + PPK E K + + + P V + ++
Sbjct: 821 KSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEP 880
Query: 97 ASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRKQGSDSEARQVG--RKVTSPSSS 154
A P S K ++K E +KV +P ++ + E ++ ++ T +
Sbjct: 881 AVEKPKES---------KVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKK 931
Query: 155 SSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENRA---PRVTVSAKEKTLL 211
+ E A+ E P +KPE E +A + K
Sbjct: 932 EPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKA 991
Query: 212 QKPHVDITDPEKPHQPKKKGSPAKPSEGR 240
+K + +K +P +K + K ++G+
Sbjct: 992 EKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 50.4 bits (119), Expect = 3e-06
Identities = 92/439 (20%), Positives = 153/439 (34%), Gaps = 52/439 (11%)
Query: 28 LASTVSLSAESGKSEKGQPQNSKKQSPP-KNVVEPKERGKLLATQTAAELSKNLSSPSSY 86
+A A S SE + + Q PP K P +R L + AA+ S++ SS S
Sbjct: 74 VAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESS 133
Query: 87 PP---------AVNKG-----------RKVASPSPSGSVLFTDEGVPKFLSRKTLVEFPQ 126
V KG K A S S S +++ PK K P
Sbjct: 134 DDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKIT---PV 190
Query: 127 KVLSPFRKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLR 186
V + + + A + SSSSSSSSS S D E + + TP +
Sbjct: 191 TVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATP----------K 240
Query: 187 KPEASHSFENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPK 246
K +AP +A T D + E+ Q KK KP P
Sbjct: 241 KTVPKKQVVAKAP--VKAATTPTRKSSSSEDSSSDEEEEQ--KKPMKNKPGPYSSVPPPS 296
Query: 247 TTMPRSQVDEEFLKQSLKEKQLQKTFRLNEIDKESQKPFEVKGPLPVHTKSGLSAPPKGS 306
P+ + + K++++++Q ++ + + +S E K P + PP
Sbjct: 297 APPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAK 356
Query: 307 PAPAVLAEEARAEGQLQASPPGAAEGHLEKPVPEPQRKAAPPLPRKETSGTQGIEGHLKG 366
A ++ + ++ P G + +P P + + Q + G
Sbjct: 357 KAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPV----GG 412
Query: 367 GQAIVEDQIPPSNLETVPVENNHGFHEKTAALKLEAEGEAMEDAA-------APGDDRGG 419
GQ ++ + S+ E E++ EKT + + +A AA AP R
Sbjct: 413 GQKLLTRKADSSSSEE---ESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDS 469
Query: 420 TQEPAPVPAEPFDNTTYKN 438
+ + +E + T K+
Sbjct: 470 SSDSDSSSSEEEEEKTSKS 488
Score = 37.4 bits (85), Expect = 0.030
Identities = 69/340 (20%), Positives = 124/340 (36%), Gaps = 50/340 (14%)
Query: 34 LSAESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPSSYP------ 87
+ + S++ + +++ PP V K K + AAE S + S S
Sbjct: 319 VESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPS 378
Query: 88 -------------------PAVNKGRKVASPSPSGSVLFT---DEGVPKFLSRKTLVEFP 125
PAV P G L T D + S + E
Sbjct: 379 KPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKT 438
Query: 126 QKVLSPFRKQGSDSEARQVGRKVT---SPSSSSSSSSSDSESDDEADVSEVTPRVVSKGR 182
+K+++ + + + A + K S SSS S SS SE ++E + K
Sbjct: 439 KKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVA 498
Query: 183 GGLRKPEASHSFENRAPRVTVSAKEKTLLQKPH-VDITDPEKPHQPKKKGSPAKPSEGRE 241
GG + + + + +A S+ + + ++ + +P PK G+ A ++ +
Sbjct: 499 GGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGK 558
Query: 242 NARPKTTMPRSQVDEEFLKQSL----KEKQLQKTFRLNEIDKESQKPFEVKGPLPVHTKS 297
A+ S+ +EE K++ K L+K + NE KE++ P K + + T +
Sbjct: 559 AAK------NSEEEEEEKKKAAVVVSKSGSLKKR-KQNEAAKEAETPQAKK--IKLQTPN 609
Query: 298 GLSAPPKG-----SPAPAVLAEEARAEGQLQASPPGAAEG 332
KG SP V EE + ++ + A G
Sbjct: 610 TFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRG 649
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 50.1 bits (118), Expect = 4e-06
Identities = 84/338 (24%), Positives = 129/338 (38%), Gaps = 46/338 (13%)
Query: 50 KKQSPPKNVVEPKERGKLLATQTAAELSKNLS---SPSSYPPAVNKGRKVASPSPSGSVL 106
K+ SP KN + KE+ K + S++ + SPS P + S SP
Sbjct: 257 KEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPS 316
Query: 107 FTDEGVPKFLSRKTLVEFPQKVLSPFRKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDD 166
P+ R+T P+++ P R + S S R+ R S S SSSSSSS S
Sbjct: 317 PRRRPSPR---RRTP---PRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSS---SRS 367
Query: 167 EADVSEVTPRVVSKGRGGLR-KPEASHSFENRAP----------RVTVSAKEKTLLQKPH 215
+ + R S R R P AS P R + + ++ +K
Sbjct: 368 RSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSR 427
Query: 216 VDITDPEKPHQPKKKGSPAKPSEGRENARP-----KTTMPRSQVDEEFLKQSLKEKQLQK 270
V ++ P + K + K +E RE+ P K + S+ D+ + Q ++
Sbjct: 428 VSVS----PGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRR 483
Query: 271 TFR----LNEIDKESQKPFEVKGPLPVHTKSG-------LSAPPKGSPAPAVLAEEARAE 319
+R + D S E + P H K+G S SP+P +E
Sbjct: 484 QYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPR 543
Query: 320 GQLQ--ASPPGAAEGHLEKPVPEPQRKAAP-PLPRKET 354
G+ + SPP P P P+R+ P P PR+ T
Sbjct: 544 GRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRT 581
Score = 47.8 bits (112), Expect = 2e-05
Identities = 100/486 (20%), Positives = 157/486 (32%), Gaps = 67/486 (13%)
Query: 24 VFRGLASTVSLSAESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSP 83
V R S+ SLS S S + ++ K+ PPK P + + L+ + ++ SP
Sbjct: 345 VRRRRRSSASLSGSSSSSSSSRSRSPPKK-PPKRTSSPPRKTRRLSPSASPPRRRHRPSP 403
Query: 84 SSYPP-------------AVNKGRKVASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLS 130
+ PP K R SP + + +G K E P
Sbjct: 404 PATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEK-------RESPSPAPK 456
Query: 131 PFRKQGSDSEARQVGRKVTSPS-------------SSSSSSSSDSESDDEADVSEVTPRV 177
P + + S+SE + G+ + S SSS S SS S D+ S V
Sbjct: 457 PRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGE 516
Query: 178 VSKGRGGLRKPEASHSFENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPS 237
V + R AS S R + + + P P + ++ SPA P
Sbjct: 517 VGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPP---------PTRRRRSPSPAPPP 567
Query: 238 EGRENARPKTTMPRSQV-DEEFLKQSLKEKQLQKTFRLNEIDKESQKPFEVKGPLPVHTK 296
R R T PR + ++S ++ + K P P +
Sbjct: 568 RRR---RTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRR 624
Query: 297 SGLSAPPK----GSPAPAVLAE---EARAEGQLQASPPGAAEGHLEKPVPEPQ-RKAAPP 348
+ S PPK SP P + + R+ G++ + PQ K P
Sbjct: 625 ASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSP 684
Query: 349 LPRKETSGTQGIEGHLKGGQAIVEDQIPPSNLETVPVENNHGFHEKTAALKLEAEGEAME 408
PR T ++ G + + + T P+ E K +
Sbjct: 685 SPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSV 744
Query: 409 DAAAPGDDRGGTQEPA----PVPAEPFDNTTYKNLQHHDYSTYTFLDLNLELSKFRMPQP 464
+ G+ EPA P P P +Q ST + ++ +K P P
Sbjct: 745 RRVSSSRSVSGSPEPAAKKPPAPPSP--------VQSQSPSTNWSPAVPVKKAKSPTPSP 796
Query: 465 SSGRES 470
S R S
Sbjct: 797 SPPRNS 802
Score = 35.8 bits (81), Expect = 0.087
Identities = 77/347 (22%), Positives = 116/347 (33%), Gaps = 61/347 (17%)
Query: 46 PQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPSSYPPAVNKGRKVASPSPSGSV 105
P + SPP P R Q S ++ PP K R ASPSP
Sbjct: 576 PPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRR--ASPSPPPKR 633
Query: 106 LFTDEGVPKFLSRKTLVEFPQKVLSPFRKQGSDSEARQVGR------------KVTSPSS 153
+ PK S + S RK S S + + R + +P +
Sbjct: 634 RVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQT 693
Query: 154 SSS------SSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENRAPRVT----V 203
SSS +SS + S R VS+ + +A+ RV+ V
Sbjct: 694 SSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSV 753
Query: 204 SAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKTTMPRSQVDEEFLKQSL 263
S + +KP P + P SPA P + ++ P + PR+ E K+
Sbjct: 754 SGSPEPAAKKPPAP-PSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKK 812
Query: 264 KEKQLQKTFRLNEIDKESQKPFEVKGPLPVHTKSGLSAPPKGSPAPAVLAEEARAEGQLQ 323
K+K DK+ +K + K + ++A + PA +A Q
Sbjct: 813 KKK-----------DKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQ-- 859
Query: 324 ASPPGAAEGHLEKPVPEPQRKAAPPLPRKET-----SGTQGIEGHLK 365
E+PV A P P+KET +E HL+
Sbjct: 860 -----------EEPV-------AAPEPKKETESEAEDNLDDLEKHLR 888
>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
sapiens]
Length = 1362
Score = 49.3 bits (116), Expect = 8e-06
Identities = 87/368 (23%), Positives = 136/368 (36%), Gaps = 49/368 (13%)
Query: 35 SAESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPSSYPPAVNKGR 94
S+ S S+K +P K + PP E +++ K ++ + +LS +++ P GR
Sbjct: 578 SSNSNVSKK-EPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKL----PGEKLGR 632
Query: 95 KV---ASPSPSGSVLFTDEGVPKF--LSRKTLVEFPQKVLSPFRK----QGSDSEARQVG 145
V S PS DE F L TL E + V S RK Q +
Sbjct: 633 VVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGS 692
Query: 146 RKVTSPSSSSSSSSSDS-ESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENRAPRVTVS 204
K+ SSS S SSS+S SD E +E+ P+ KG G + + H + +
Sbjct: 693 SKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAP 752
Query: 205 AKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKTTMPRSQVDEEFLKQSLK 264
Q+P P P P+++ P P P +MP+ + +
Sbjct: 753 VP-----QQPPPPPQQPPPPPPPQQQQQPPPPP-------PPPSMPQ--------QAAPA 792
Query: 265 EKQLQKTFRLNEID-KESQKPFEVKGPLPVHTKSGLSAP----PKGSPAPAVLAEEARAE 319
K F ++ E Q P V P+ T+ L P P P P +
Sbjct: 793 MKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLN 852
Query: 320 GQLQASPPGAAEGHLEKPVPEPQRKAA-PPLPRKETSGTQGI--------EGHLKGGQAI 370
SPP ++P R AA PP P + + + + + Q +
Sbjct: 853 QHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVL 912
Query: 371 VEDQIPPS 378
+ED+ PP+
Sbjct: 913 LEDEEPPA 920
Score = 39.3 bits (90), Expect = 0.008
Identities = 45/168 (26%), Positives = 64/168 (38%), Gaps = 44/168 (26%)
Query: 148 VTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENRAPRVTVSAKE 207
V PSSS SSS S S+SD D SE E RA R+ ++
Sbjct: 480 VAPPSSSDSSSDSSSDSDSSTDDSE----------------------EERAQRLAELQEQ 517
Query: 208 KTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKTTMPRSQVDEEFLKQSLKEKQ 267
+ + ++ P++ ++PKKK E + + K R + EE K KE
Sbjct: 518 LKAVHEQLAALSQPQQ-NKPKKK-------EKDKKEKKKEKHKRKEEVEENKKSKAKEPP 569
Query: 268 LQKTFRLNEIDKESQKPFEVKGPLPVHTKSGLSAPPKGSPAPAVLAEE 315
+KT + N + K K P AP K P P +EE
Sbjct: 570 PKKTKKNNSSNSNVSK----KEP----------APMKSKPPPTYESEE 603
>gi|68348716 AF4/FMR2 family, member 3 isoform 2 [Homo sapiens]
Length = 1251
Score = 49.3 bits (116), Expect = 8e-06
Identities = 69/269 (25%), Positives = 103/269 (38%), Gaps = 33/269 (12%)
Query: 137 SDSEA-RQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFE 195
SDS +Q + + PSS SSSSS S S + SE + S+ + E S
Sbjct: 418 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPH 477
Query: 196 NRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARP-KTTMPRSQV 254
+P ++ K L K ++ +P KP P + + SE + P K +
Sbjct: 478 FSSPEAEPASSNKWQLDK-WLNKVNPHKP--PILIQNESHGSESNQYYNPVKEDVQDCGK 534
Query: 255 DEEFLKQSLKEKQLQKTFRLNEIDKESQKPFEV-KGPLPVHTKSGLSAPPKGSPAPAVLA 313
+ + SL+EK+++ T KE Q+P K P K PA +A
Sbjct: 535 VPDVCQPSLREKEIKSTC------KEEQRPRTANKAP------GSKGVKQKSPPAAVAVA 582
Query: 314 EEARAEGQLQASPPGAAEGHLEKPVPEPQRKAAPPLPRKETSGTQGIEG---HLKGGQAI 370
A A+PP A + P P R++A P + T T +G H A
Sbjct: 583 VSA-------AAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAA 635
Query: 371 VED-----QIPPSNLETVPVENNHGFHEK 394
+ +PP +T P NN H K
Sbjct: 636 ADALGTSVVVPPEPTKTRPCGNNRASHRK 664
>gi|68348714 AF4/FMR2 family, member 3 isoform 1 [Homo sapiens]
Length = 1226
Score = 49.3 bits (116), Expect = 8e-06
Identities = 69/269 (25%), Positives = 103/269 (38%), Gaps = 33/269 (12%)
Query: 137 SDSEA-RQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFE 195
SDS +Q + + PSS SSSSS S S + SE + S+ + E S
Sbjct: 393 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPH 452
Query: 196 NRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARP-KTTMPRSQV 254
+P ++ K L K ++ +P KP P + + SE + P K +
Sbjct: 453 FSSPEAEPASSNKWQLDK-WLNKVNPHKP--PILIQNESHGSESNQYYNPVKEDVQDCGK 509
Query: 255 DEEFLKQSLKEKQLQKTFRLNEIDKESQKPFEV-KGPLPVHTKSGLSAPPKGSPAPAVLA 313
+ + SL+EK+++ T KE Q+P K P K PA +A
Sbjct: 510 VPDVCQPSLREKEIKSTC------KEEQRPRTANKAP------GSKGVKQKSPPAAVAVA 557
Query: 314 EEARAEGQLQASPPGAAEGHLEKPVPEPQRKAAPPLPRKETSGTQGIEG---HLKGGQAI 370
A A+PP A + P P R++A P + T T +G H A
Sbjct: 558 VSA-------AAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAA 610
Query: 371 VED-----QIPPSNLETVPVENNHGFHEK 394
+ +PP +T P NN H K
Sbjct: 611 ADALGTSVVVPPEPTKTRPCGNNRASHRK 639
>gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]
Length = 953
Score = 49.3 bits (116), Expect = 8e-06
Identities = 79/341 (23%), Positives = 127/341 (37%), Gaps = 46/341 (13%)
Query: 30 STVSLSAESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPSSYPPA 89
S+ S S +S P S SP + + K A K++ P+ PPA
Sbjct: 590 SSFSGSRSRSRSFSSSPSPSPTPSPHRPSIRTKGEP---APPPGKAGEKSVKKPAP-PPA 645
Query: 90 VNKGRKVASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRK-------------QG 136
+ K +P P T G P+ RK E P + P R+ G
Sbjct: 646 PPQATKTTAPVPEP----TKPGDPREARRK---ERPART-PPRRRTLSGSGSGSGSSYSG 697
Query: 137 SDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFEN 196
S S +R + S SS++SSSS + S D D+ L P +S S +
Sbjct: 698 SSSRSRSLSVSSVSSVSSATSSSSSAHSVDSEDMY-----------ADLASPVSSASSRS 746
Query: 197 RAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKTTMPRSQVDE 256
AP T KEK +K + K + AKP G ++++ +T ++ +
Sbjct: 747 PAPAQT--RKEKGKSKKEDGVKEEKRKRDSSTQPPKSAKPPAGGKSSQQPSTPQQAPPGQ 804
Query: 257 EFLKQSLKEKQLQKTFRLNEIDKESQKPFEVKGPLPVHTKSGLSAPPKGSP--APAVLAE 314
+ K+++ T DK S+K +E K S PP P +P +
Sbjct: 805 PQQGTFVAHKEIKLTLLNKAADKGSRKRYEPS------DKDRQSPPPAKRPNTSPDRGSR 858
Query: 315 EARAEGQLQASPPGAAEGHLEKPVPEPQRKAAPPLPRKETS 355
+ ++ G+L + P G K P + P+ ++S
Sbjct: 859 DRKSGGRLGSPKPERQRGQNSKAPAAPADRKRQLSPQSKSS 899
Score = 36.2 bits (82), Expect = 0.066
Identities = 63/297 (21%), Positives = 101/297 (34%), Gaps = 52/297 (17%)
Query: 82 SPSSYPPAVN-KGRKVASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRKQGSDSE 140
+PS + P++ KG P +G P + T P V P K G E
Sbjct: 611 TPSPHRPSIRTKGEPAPPPGKAGEKSVKKPAPPPAPPQATKTTAP--VPEP-TKPGDPRE 667
Query: 141 ARQVGRKVTSPS-----SSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFE 195
AR+ R +P S S S S S S + ++ VS ++HS +
Sbjct: 668 ARRKERPARTPPRRRTLSGSGSGSGSSYSGSSSRSRSLSVSSVSSVSSATSSSSSAHSVD 727
Query: 196 NRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKTTMPRSQVD 255
+ + + D+ P + SPA +E + K
Sbjct: 728 S---------------EDMYADLASPVSSASSR---SPAPAQTRKEKGKSKK-------- 761
Query: 256 EEFLKQSLKEKQLQKTFRLNEIDKESQKPFEVKGPLPVHTKSGLSAP---PKGSPAPAVL 312
+ +KE++ ++ D +Q P K P + S P P G P
Sbjct: 762 ----EDGVKEEKRKR-------DSSTQPPKSAKPPAGGKSSQQPSTPQQAPPGQPQQGTF 810
Query: 313 AEEARAEGQLQASPPGAAEGHLEKPVP-EPQRKAAPPLPRKETSGTQGIEGHLKGGQ 368
A E +L A +G ++ P + R++ PP R TS +G GG+
Sbjct: 811 V--AHKEIKLTLLNKAADKGSRKRYEPSDKDRQSPPPAKRPNTSPDRGSRDRKSGGR 865
Score = 33.9 bits (76), Expect = 0.33
Identities = 70/338 (20%), Positives = 106/338 (31%), Gaps = 46/338 (13%)
Query: 40 KSEKGQPQNSKKQSPPKNVVEPKERGKLLATQT-----------AAELSKNLSSPSSYPP 88
+ EKG+P+ Q P + PK+ Q ++ K S P
Sbjct: 477 EKEKGKPKPRSPQPPSRQAEPPKKEAATTGPQVKRADEWKDPWRRSKSPKKKLGVSVSPS 536
Query: 89 AVNKGRKVASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRKQGSDSEARQVGRKV 148
+ RK ++ S S S + SR + S R S + + R
Sbjct: 537 RARRRRKTSASSASAS------NSSRSSSRSSSYSGSGSSRSRSRSSSYSSYSSRSSRHS 590
Query: 149 TSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASH-SFENRAPRVTVSAKE 207
+ S S S S S S P + +KG +A S + AP
Sbjct: 591 SFSGSRSRSRSFSSSPSPSPTPSPHRPSIRTKGEPAPPPGKAGEKSVKKPAPPPAPPQAT 650
Query: 208 KTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKTTMPR--------SQVDEEFL 259
KT P +P KP P+ E R RP T PR S +
Sbjct: 651 KTTAPVP-----EPTKPGDPR---------EARRKERPARTPPRRRTLSGSGSGSGSSYS 696
Query: 260 KQSLKEKQL--QKTFRLNEIDKESQKPFEVKG-PLPVHTKSGLSAPPKGSPAPAVLAEEA 316
S + + L ++ S V + S +S+ SPAPA +E
Sbjct: 697 GSSSRSRSLSVSSVSSVSSATSSSSSAHSVDSEDMYADLASPVSSASSRSPAPAQTRKE- 755
Query: 317 RAEGQLQASPPGAAEGHLEKPVPEPQRKAAPPLPRKET 354
+G+ + E +P + A PP K +
Sbjct: 756 --KGKSKKEDGVKEEKRKRDSSTQPPKSAKPPAGGKSS 791
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 47.4 bits (111), Expect = 3e-05
Identities = 65/287 (22%), Positives = 104/287 (36%), Gaps = 30/287 (10%)
Query: 77 SKNLSSPSSYPPAVNKGRKVASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRKQG 136
S SS P AV K ++ S S VL + VP+ SR E SP K G
Sbjct: 1378 SSGHSSSELSPDAVEKAGMSSNQSISSPVL---DAVPRTPSR----ERSSSASSPEMKDG 1430
Query: 137 SDSEARQVGRKVTSPS--SSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSF 194
+ R +SP S + S S S + ++ PR S+GR
Sbjct: 1431 LPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDI-PRTPSRGRS----------- 1478
Query: 195 ENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKTTMPRSQV 254
S + K L Q P P P K +P + G E++ + T+ R+ +
Sbjct: 1479 -----ECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPL 1533
Query: 255 DEEFLKQSLKEKQLQKTFRLNEIDKESQKP---FEVKGPLPVHTKSGLSAPPKGSPAPAV 311
+ S +E ++ + E + P + + PL ++SG S +
Sbjct: 1534 GQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSP 1593
Query: 312 LAEEARAEGQLQASPPGAAEGHL-EKPVPEPQRKAAPPLPRKETSGT 357
+ + +++ P A PEP+ A LPR+ SG+
Sbjct: 1594 RRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGS 1640
Score = 42.7 bits (99), Expect = 7e-04
Identities = 76/323 (23%), Positives = 109/323 (33%), Gaps = 48/323 (14%)
Query: 46 PQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPSSYPPAVNKGRKVASPS-PSGS 104
P + +SP + + R L+A T S++LSS + + G S P+
Sbjct: 2442 PAQDQPRSPVPSAFSDQSRC-LIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPG 2500
Query: 105 VLFTDEGVPKFLSRKTLVEFPQKV--LSPF--RKQGSDSEARQVGRKVTSPSSSSSSSSS 160
V +D G P T + P + L P R+ S S + +S SSSSSSSS
Sbjct: 2501 VPHSDVGEPP---ASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSG 2557
Query: 161 DSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENRAPRVTVSAKEKTLLQKPHVDITD 220
S SD E V P V K R P T + KE +P
Sbjct: 2558 SSSSDSEGSSLPVQPEVALK----------------RVPSPTPAPKEAVREGRP------ 2595
Query: 221 PEKPHQPKKKGSPAKPSEGRENARPKTTMPRSQVDEEFLKQSLKEKQLQKTFRLNEIDKE 280
PE +K+ S + S ++ ++ S S
Sbjct: 2596 PEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS----------SSS 2645
Query: 281 SQKPFEVK-GPLPVHTKSGLSAPPKG---SPAPAVLAEEARAEGQLQASPPGAAEGHLEK 336
S P K GP + + PP G S +P + R L SP E
Sbjct: 2646 SSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSP---VERRRPS 2702
Query: 337 PVPEPQRKAAPPLPRKETSGTQG 359
P P P+ + + R G +G
Sbjct: 2703 PQPSPRDQQSSSSERGSRRGQRG 2725
Score = 39.7 bits (91), Expect = 0.006
Identities = 69/311 (22%), Positives = 110/311 (35%), Gaps = 54/311 (17%)
Query: 130 SPFRKQGSDSEARQVGRKVTSPSSSSSSSSS-----DSESDDEADVSEVTPRVVSKGRGG 184
SP K+ S R R ++SP S + S S S S+ PR + R G
Sbjct: 746 SPEMKKSRISSRRS--RSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPR---RSRSG 800
Query: 185 LRKPEASHSFENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENAR 244
+P+A R R + S K + P PH K G+P P +G
Sbjct: 801 SSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTP--PRQG----- 853
Query: 245 PKTTMPRSQVDEEFLKQSLKEKQLQKTFRLN---EIDKESQKPFEVKGPLPVHTKSGLSA 301
T P++ +QS+ Q + F + E+ + G P KS S
Sbjct: 854 -SITSPQAN------EQSV-TPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKS--ST 903
Query: 302 PPKGSPAPAVLAEEARAEGQLQASPPGAAEGHLEKPVPEPQRKAAPPLPR--KETSGTQG 359
PP+ SP + + + +++A H P P R + PR + S
Sbjct: 904 PPRQSP-----SRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSN 958
Query: 360 IEGHL-----KGGQAIVEDQIPPSNLETVPVENNHGFHEKTAALKLEAEGEAMEDAAAPG 414
+E L G + + ++ P ET P +++ G +K + PG
Sbjct: 959 VESRLLPRYSHSGSSSPDTKVKP---ETPPRQSHSGSISPYPKVKAQ---------TPPG 1006
Query: 415 DDRGGTQEPAP 425
G++ P P
Sbjct: 1007 PSLSGSKSPCP 1017
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 47.0 bits (110), Expect = 4e-05
Identities = 96/431 (22%), Positives = 148/431 (34%), Gaps = 68/431 (15%)
Query: 5 CLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSKKQSPPKNVV----E 60
C +++ G L + Q A + SA S S + Q + KK + PK + E
Sbjct: 640 CQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPE 699
Query: 61 PKERGKLLATQT-----AAELSKNLSSPSSYPPAVNKGRKVASPSPSGSVLFTDEGVPKF 115
PK+ L+ T +A+ + + S PA K V S V PK
Sbjct: 700 PKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKM 759
Query: 116 LSRKT-LVEFPQKVLSPFRKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVT 174
+ T LV P S Q K T P + S+ S S VS
Sbjct: 760 VKPTTDLVSSSSATTKP--DIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFD 817
Query: 175 PRVVSKGRGGLRKPEASH---SFENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKG 231
+ + + + SH S E++ + ++K +K ++ P+ +P KG
Sbjct: 818 SKAIPRPASDSKI--ISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMS-PKPDAKPMPKG 874
Query: 232 SPAKPSEGRENARPKT--TMPRSQVDEEFLKQSLKEKQLQKTFRLN-------------- 275
SP P RP T+P Q QS K ++ + F LN
Sbjct: 875 SPTPPGP-----RPTAGQTVPTPQ-------QSPKPQEQSRRFSLNLGSITDAPKSQPTT 922
Query: 276 --------------EIDKESQKPFEVKGPLPVHTKSGLSAPPKGSPAPA---VLAEEARA 318
I ++ G H++SG AP K +PAP+ ++
Sbjct: 923 PQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKS 982
Query: 319 EGQLQASPPGAAEGHLEKPVP-----EPQRKAAPPLPRKETSGTQGIEGHLKGGQAIVED 373
GQ +P + E P EP+ + AP + R ET K A +
Sbjct: 983 TGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQK 1042
Query: 374 QIPPSNLETVP 384
+ P+ LE P
Sbjct: 1043 AVLPTKLEKSP 1053
Score = 31.2 bits (69), Expect = 2.1
Identities = 84/413 (20%), Positives = 144/413 (34%), Gaps = 49/413 (11%)
Query: 27 GLASTVSLSAESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPS-S 85
GL ++ +A +G G S P + + + Q AA +S+ P S
Sbjct: 11 GLPEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGS 70
Query: 86 YPPAVNKGRKVASPSPSGSVLFTDEGVPKFLSRKTLVEFP-QKVLSPFRKQGS-DSEARQ 143
PPA + SPS PK R P Q LS R + SE +
Sbjct: 71 VPPAAAE-----SPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKL 125
Query: 144 VGRKVTSPSSSSSSSSSDSESDDEADV-----SEVTPRVVSKGRGGLRKPEASHSFENRA 198
GR ++ S S S +D + + ++ + SEV +S + K +
Sbjct: 126 PGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVN--ALSAVSSVVNKFNPFDLISDSE 183
Query: 199 PRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKTTMP-RSQVDEE 257
+ K++ ++QK PE +P + P KP PK P R + ++
Sbjct: 184 ASQEETTKKQKVVQKEQ---GKPEGIIKPPLQQQPPKPI-------PKQQGPGRDPLQQD 233
Query: 258 FLKQSLKEKQLQKTFRLNEIDKESQKPFE--VKGPLPVHTKSGL---SAPPKGSPAPAVL 312
+S+ +Q +K + + KP + + P H K L ++ P+ A V
Sbjct: 234 GTPKSISSQQPEK---IKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVR 290
Query: 313 AEEARAEGQLQASPPGAAEGHLEKPVPEPQRKAAPPLPRKETSGTQGIEGHLKGGQAIVE 372
E + + PP + P +P + + P P K + G+ L V+
Sbjct: 291 GESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVK 350
Query: 373 DQIPPSNLETVPVENNHGFHEKTAALKLEAEGEAMEDAAAPGDDRGGTQEPAP 425
+ P P + G A A G ++ +++P P
Sbjct: 351 PPVQPPGTTKPPA---------------QPLGPAKPPAQQTGSEKPSSEQPGP 388
Score = 31.2 bits (69), Expect = 2.1
Identities = 52/239 (21%), Positives = 86/239 (35%), Gaps = 12/239 (5%)
Query: 30 STVSLSAESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPSSYPPA 89
S SL +S S P + K +S + + G LL T + + L
Sbjct: 1733 SVSSLDEDSDSS----PSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKE 1788
Query: 90 VNKGRKVASPSPSGSVLFT--DEGVPKFLSRKTLVEFPQKVLSPFRKQGSDSEARQVGRK 147
K R++ S + D+ + R+ + P LSP E RQ
Sbjct: 1789 QEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEM 1848
Query: 148 VTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENRAPRVTVSAKE 207
SS S S ESD E E++P + + + + P A S + ++ KE
Sbjct: 1849 EELHRSSCSEYSPSIESDPEG--FEISPEKIIEVQKVYKLPTAV-SLYSPTDEQSIMQKE 1905
Query: 208 KTLLQKPHVDITDPEKPHQPKK-KGSPAKPSEGRENARPKTTMPRSQVDEEFLKQSLKE 265
+ + E H+ K K PA + R+ K + + E+++ +SL E
Sbjct: 1906 GSQKALKSAEEMYEEMMHKTHKYKAFPA--ANERDEVFEKEPLYGGMLIEDYIYESLVE 1962
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 47.0 bits (110), Expect = 4e-05
Identities = 96/431 (22%), Positives = 148/431 (34%), Gaps = 68/431 (15%)
Query: 5 CLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSKKQSPPKNVV----E 60
C +++ G L + Q A + SA S S + Q + KK + PK + E
Sbjct: 640 CQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPE 699
Query: 61 PKERGKLLATQT-----AAELSKNLSSPSSYPPAVNKGRKVASPSPSGSVLFTDEGVPKF 115
PK+ L+ T +A+ + + S PA K V S V PK
Sbjct: 700 PKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKM 759
Query: 116 LSRKT-LVEFPQKVLSPFRKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVT 174
+ T LV P S Q K T P + S+ S S VS
Sbjct: 760 VKPTTDLVSSSSATTKP--DIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFD 817
Query: 175 PRVVSKGRGGLRKPEASH---SFENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKG 231
+ + + + SH S E++ + ++K +K ++ P+ +P KG
Sbjct: 818 SKAIPRPASDSKI--ISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMS-PKPDAKPMPKG 874
Query: 232 SPAKPSEGRENARPKT--TMPRSQVDEEFLKQSLKEKQLQKTFRLN-------------- 275
SP P RP T+P Q QS K ++ + F LN
Sbjct: 875 SPTPPGP-----RPTAGQTVPTPQ-------QSPKPQEQSRRFSLNLGSITDAPKSQPTT 922
Query: 276 --------------EIDKESQKPFEVKGPLPVHTKSGLSAPPKGSPAPA---VLAEEARA 318
I ++ G H++SG AP K +PAP+ ++
Sbjct: 923 PQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKS 982
Query: 319 EGQLQASPPGAAEGHLEKPVP-----EPQRKAAPPLPRKETSGTQGIEGHLKGGQAIVED 373
GQ +P + E P EP+ + AP + R ET K A +
Sbjct: 983 TGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQK 1042
Query: 374 QIPPSNLETVP 384
+ P+ LE P
Sbjct: 1043 AVLPTKLEKSP 1053
Score = 31.2 bits (69), Expect = 2.1
Identities = 84/413 (20%), Positives = 144/413 (34%), Gaps = 49/413 (11%)
Query: 27 GLASTVSLSAESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPS-S 85
GL ++ +A +G G S P + + + Q AA +S+ P S
Sbjct: 11 GLPEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGS 70
Query: 86 YPPAVNKGRKVASPSPSGSVLFTDEGVPKFLSRKTLVEFP-QKVLSPFRKQGS-DSEARQ 143
PPA + SPS PK R P Q LS R + SE +
Sbjct: 71 VPPAAAE-----SPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKL 125
Query: 144 VGRKVTSPSSSSSSSSSDSESDDEADV-----SEVTPRVVSKGRGGLRKPEASHSFENRA 198
GR ++ S S S +D + + ++ + SEV +S + K +
Sbjct: 126 PGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVN--ALSAVSSVVNKFNPFDLISDSE 183
Query: 199 PRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKTTMP-RSQVDEE 257
+ K++ ++QK PE +P + P KP PK P R + ++
Sbjct: 184 ASQEETTKKQKVVQKEQ---GKPEGIIKPPLQQQPPKPI-------PKQQGPGRDPLQQD 233
Query: 258 FLKQSLKEKQLQKTFRLNEIDKESQKPFE--VKGPLPVHTKSGL---SAPPKGSPAPAVL 312
+S+ +Q +K + + KP + + P H K L ++ P+ A V
Sbjct: 234 GTPKSISSQQPEK---IKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVR 290
Query: 313 AEEARAEGQLQASPPGAAEGHLEKPVPEPQRKAAPPLPRKETSGTQGIEGHLKGGQAIVE 372
E + + PP + P +P + + P P K + G+ L V+
Sbjct: 291 GESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVK 350
Query: 373 DQIPPSNLETVPVENNHGFHEKTAALKLEAEGEAMEDAAAPGDDRGGTQEPAP 425
+ P P + G A A G ++ +++P P
Sbjct: 351 PPVQPPGTTKPPA---------------QPLGPAKPPAQQTGSEKPSSEQPGP 388
Score = 31.2 bits (69), Expect = 2.1
Identities = 52/239 (21%), Positives = 86/239 (35%), Gaps = 12/239 (5%)
Query: 30 STVSLSAESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPSSYPPA 89
S SL +S S P + K +S + + G LL T + + L
Sbjct: 1733 SVSSLDEDSDSS----PSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKE 1788
Query: 90 VNKGRKVASPSPSGSVLFT--DEGVPKFLSRKTLVEFPQKVLSPFRKQGSDSEARQVGRK 147
K R++ S + D+ + R+ + P LSP E RQ
Sbjct: 1789 QEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEM 1848
Query: 148 VTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENRAPRVTVSAKE 207
SS S S ESD E E++P + + + + P A S + ++ KE
Sbjct: 1849 EELHRSSCSEYSPSIESDPEG--FEISPEKIIEVQKVYKLPTAV-SLYSPTDEQSIMQKE 1905
Query: 208 KTLLQKPHVDITDPEKPHQPKK-KGSPAKPSEGRENARPKTTMPRSQVDEEFLKQSLKE 265
+ + E H+ K K PA + R+ K + + E+++ +SL E
Sbjct: 1906 GSQKALKSAEEMYEEMMHKTHKYKAFPA--ANERDEVFEKEPLYGGMLIEDYIYESLVE 1962
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 46.6 bits (109), Expect = 5e-05
Identities = 90/389 (23%), Positives = 135/389 (34%), Gaps = 45/389 (11%)
Query: 46 PQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPSSYPPAVNKGRKVASPSPSGSV 105
P+ K+ P K V P + + E+ K P A+ K SP P V
Sbjct: 10610 PEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPP--KPESPPPE--V 10665
Query: 106 LFTDEGVPKFLSRKTLVEFPQKVLSPFRKQGSDSEARQVGRKVTSPSSSSSSSSSDSESD 165
E V +VE P+ P V K P + + +
Sbjct: 10666 FEEPEEVALEEPPAEVVEEPEPAAPP---------QVTVPPKKPVPEKKAPAVVAKKPEL 10716
Query: 166 DEADVSEVTPRVVSKGRGGL---RKPEASHSFENRAPRVTVSAKEKTLLQKPHVDITD-P 221
V EV VV + + L +KPEA + P+ V K+ + +KP V P
Sbjct: 10717 PPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVP 10776
Query: 222 EKPHQPKKKGSPAKPSEGRENARPKTTMPRSQVDEEFLKQSLKEKQLQKTFRLNEIDKES 281
E P +P + PA P R + P +V EE EI E
Sbjct: 10777 EVPKKPVLEEKPAVPVPERAESPPP------EVYEE----------------PEEIAPEE 10814
Query: 282 QKPFEVKGPLPVHTKSGLSAPPKGSPA-PAVLAEEARAE--GQLQASPPGAAEGH--LEK 336
+ E + P+PV + PP P P + E + + +A PP E +EK
Sbjct: 10815 EIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEK 10874
Query: 337 PVPEPQRKAAPPLPRKETSGTQGIEGHLKGGQAIVEDQIPPSNLETVPVENNHGFHEKTA 396
P +P+ PP P KE + + + + E P +E P++ G +K
Sbjct: 10875 PKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGG-EKKVR 10933
Query: 397 ALKLEAEGEAMEDAAAPGDDRGGTQEPAP 425
L E + E E+ R +E P
Sbjct: 10934 KLLPERKPEPKEEVVLKSVLRKRPEEEEP 10962
Score = 43.9 bits (102), Expect = 3e-04
Identities = 81/345 (23%), Positives = 126/345 (36%), Gaps = 31/345 (8%)
Query: 54 PPKNVVEPKERGKLLATQTAAELSKNLSSPSSYPPAVNKGRKVASPSPSGSVLFTDEGVP 113
PPK VV K+ A + A K +P P +KV P P E P
Sbjct: 10500 PPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPE----KKVPVPPPK-----KPEVPP 10550
Query: 114 KFLSRKTLVEFPQKVLS---PFRKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADV 170
+ P+K + P + + E + ++V P ++ V
Sbjct: 10551 TKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVV-PEKKVPAAPPKKPEVTPVKV 10609
Query: 171 SEVTPRVVSKGRGGL---RKPEASHSFENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQP 227
E VV + + + +KPE + P+V V K+ P + PE +P
Sbjct: 10610 PEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEP 10669
Query: 228 KKKGSPAKPSEGRENARPK-----TTMPRSQVDEEFLKQSLKEKQLQKTFRLNEIDKESQ 282
++ P+E E P T P+ V E+ + +K ++ E+ KE
Sbjct: 10670 EEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVV 10729
Query: 283 KPFEVKGPLPVHTKSGLSAPPKGSP--APAVLAEEARAEGQLQASPPGAAEGHLEKPVPE 340
E K PL V K APP P V+ E+ A + PP +KPV E
Sbjct: 10730 P--EKKVPLVVPKKP--EAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLE 10785
Query: 341 PQRKAAPPLPRKETSGTQGIEGHLKGGQAIVEDQIPPSNLETVPV 385
K A P+P + S E + + + E++I P + VPV
Sbjct: 10786 --EKPAVPVPERAESPPP--EVYEEPEEIAPEEEIAPEEEKPVPV 10826
Score = 38.9 bits (89), Expect = 0.010
Identities = 53/222 (23%), Positives = 89/222 (40%), Gaps = 25/222 (11%)
Query: 214 PHVDITDPEKPHQPKKKGSPAKPSEGRENARPKTTMPRSQVDEEFLKQSLKEKQLQKTFR 273
P + + PE P +P + P ++ A P + EE + + +K+ +
Sbjct: 9944 PVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAK 10003
Query: 274 LNEIDKESQKPF-EVKGPLPVHTKSGLSAPPKGSP-APAVLAEEAR----AEGQLQASPP 327
+ E+ K KP E K P+PV K + APP P P E + A +++A P
Sbjct: 10004 VPEVPK---KPVPEEKVPVPVPKK--VEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPA 10058
Query: 328 GAAE------GHLEKPVPEPQRKAAPP--LPRKETSGTQGI-----EGHLKGGQAIVEDQ 374
E +KP P P++ APP +P+K + E L + + E++
Sbjct: 10059 KVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEE 10118
Query: 375 IPPSNLETVPVENNHGFHEKTAALKLEAEGEAMEDAAAPGDD 416
+ P E +P E E+ L E E E+ P ++
Sbjct: 10119 VLPEEEEVLP-EEEEVLPEEEEVLPEEEEIPPEEEEVPPEEE 10159
Score = 36.6 bits (83), Expect = 0.051
Identities = 86/372 (23%), Positives = 137/372 (36%), Gaps = 56/372 (15%)
Query: 46 PQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPSSYPPAVNKGRKVASPSPSGSV 105
P KK++PP V P+ + ++ + +++ SP PPAV + K P V
Sbjct: 9360 PVAKKKEAPPAKV--PEVQKGVVTEEKITIVTQREESP---PPAVPEIPKKKVPEERKPV 9414
Query: 106 LFTDEGVPKFLSRKTLVEFP---QKVLSPFRKQGSDSEARQVGRKVTSPSSSSSSSSSDS 162
+E VP L + P +KV P V +K P + S +
Sbjct: 9415 PRKEEEVPPPPKVPALPKKPVPEEKVAVPV----------PVAKKAPPPRAEVSKKTVVE 9464
Query: 163 ESDDEAD--VSEVTPRVVSKGRGGLRKPEA-SHSFENRAPRVTVSAKEKTLLQKPHVDIT 219
E A+ +S P+ V R + E S+S E ++V +E+ ++ ++T
Sbjct: 9465 EKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEERE-EEEEAEVT 9523
Query: 220 DPEKPHQPKKKGSPAKPSEGRENARPKTTMPRSQVDEEFLKQSLKEKQLQKTFRLNEIDK 279
+ E +P++ K + +V+ E + E+Q +K +I
Sbjct: 9524 EYEVMEEPEEYV-----------VEEKLHIISKRVEAE--PAEVTERQEKKIVLKPKIPA 9570
Query: 280 ESQKPFEVKGPLPVHTKSGLSAPPKGSPAPAVLAEEARAEGQLQASPPGAAEGHLEKPVP 339
+ ++P P V P K PAP E+ PP +KPVP
Sbjct: 9571 KIEEP----PPAKVPEAPKKIVPEKKVPAPVPKKEKV---------PPPKVPEEPKKPVP 9617
Query: 340 EPQR-----KAAPPLPRKETSGTQGIEGHLKGGQAIVEDQIPPSNLETVPVENNHGF-HE 393
E + K PLP K T I K A+ + + PP VP E E
Sbjct: 9618 EKKVPPKVIKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPK--ARVPEEPKRAVPEE 9675
Query: 394 KTAALKLEAEGE 405
K LK + E E
Sbjct: 9676 KVLKLKPKREEE 9687
Score = 36.2 bits (82), Expect = 0.066
Identities = 71/323 (21%), Positives = 117/323 (36%), Gaps = 41/323 (12%)
Query: 46 PQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNL-----SSPSSYPPAVNKGRKVASPS 100
P + +SPP V E E + A E K + P PPAV + K P
Sbjct: 10791 PVPERAESPPPEVYEEPEE-IAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPE 10849
Query: 101 PSGSVLFTDEGVP-KFLSRKTLVEFPQKVLSPFRKQGSDSEARQ-VGRKVTSPSSSSSSS 158
V+ E P K + ++E P+ L P + ++ V K+ +
Sbjct: 10850 KKVPVIKKPEAPPPKEPEPEKVIEKPK--LKPRPPPPPPAPPKEDVKEKIFQLKAIPKKK 10907
Query: 159 SSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENRAPRVTVSAKEKTLLQKPHVDI 218
+ E E+TP V G +RK R P K++L+K
Sbjct: 10908 VPEKPQVPEK--VELTPLKVPGGEKKVRK-----LLPERKPEPKEEVVLKSVLRK----- 10955
Query: 219 TDPEKPHQPKKKGSPAKPSEGRENARPKTTMPRSQVDEEFLKQSLKEKQLQKTFRLNEID 278
+P + + K P K + ++ A P+ P+ + E + +E+++ + ++ EI
Sbjct: 10956 ----RPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIK 11011
Query: 279 KESQKPFEVKGPLPVHTKSGLSAPPKGSPAPAVLA-----------EEARAEGQLQASPP 327
P P P + PP P P +A EA+A + A P
Sbjct: 11012 PAIPLPAPEPKPKPEAEVKTIKPPPV-EPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPK 11070
Query: 328 GAAEGHLEK---PVPEPQRKAAP 347
G +G +K P+ +RK P
Sbjct: 11071 GPIKGVPKKTPSPIEAERRKLRP 11093
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 46.6 bits (109), Expect = 5e-05
Identities = 99/468 (21%), Positives = 166/468 (35%), Gaps = 64/468 (13%)
Query: 8 RQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSKKQ---SPPKNVVEPKER 64
+ A T++ E + G +A+ G GQ +S + S + VE K
Sbjct: 159 KSAEPSANTTLVSETEE-EGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKAS 217
Query: 65 GKLLATQTAAELSKNLSSPSSYPPAVNKGRKVASPSPSGSVLFTDEGVPKFLSRKTLVEF 124
K+L + A+ +K + P K VAS + +G E + S
Sbjct: 218 EKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETP 277
Query: 125 PQKVLSPFRKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGG 184
K L + G S QVG ++S+ + S + A + P V+K + G
Sbjct: 278 AAKALLQAKASGKTS---QVG------AASAPAKESPRKGAAPAPPGKTGP-AVAKAQAG 327
Query: 185 LRKPEASHSFENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSE------ 238
R+ ++ S E A+ K + P V P+K +PA P +
Sbjct: 328 KREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAA 387
Query: 239 ----GRENARPKTTMPRSQVDEEFL--KQSLKEKQLQKTFRLNEIDKESQKPF-EVKGPL 291
G++ +++ S D E L + + K L K+ ++ P + GP+
Sbjct: 388 QVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPV 447
Query: 292 P-------------------VHTKSGLSAPPKGSPAPAVL--AEEARAEGQLQASPPGA- 329
P + S S+ P + A+E LQA P +
Sbjct: 448 PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSP 507
Query: 330 AEGHLEKPVP-EPQRKAAPPLPRKETS-------GTQGIEGHLKGGQAIVEDQIPPSNLE 381
A+G +K P Q KA P+ E+S ++ + QA +IP + +
Sbjct: 508 AKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT--K 565
Query: 382 TVPVENNHGFHEKTAALKLEAE-----GEAMEDAAAPGDDRGGTQEPA 424
P + N K A +++ + G A A + GGTQ PA
Sbjct: 566 ACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA 613
Score = 41.6 bits (96), Expect = 0.002
Identities = 68/313 (21%), Positives = 110/313 (35%), Gaps = 36/313 (11%)
Query: 133 RKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASH 192
RK+ ++ +A +K S+S SS+ E + EA+ ++ TPR+ S L +
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVL-GADLPS 119
Query: 193 SFENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPK-TTMPR 251
S + +A T A KT PH P K + R++A P T
Sbjct: 120 SMKEKAKAETEKA-GKTGNSMPH--------PATGKTVANLLSGKSPRKSAEPSANTTLV 170
Query: 252 SQVDEEFLKQSLKEKQLQKTFRLNEIDKES--------QKPFEVKGPLPVHTKSGLSAPP 303
S+ +EE + + D S + EVK + SAP
Sbjct: 171 SETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPA 230
Query: 304 KGSP----APAVLAEEARAEGQLQASPP--GAAEGHLEKPVPEPQRKAAPPLPRKETSGT 357
KG+P PA + Q +A P + E E + AA L + + SG
Sbjct: 231 KGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASG- 289
Query: 358 QGIEGHLKGGQAIVEDQIPPSNLETVPVENNHGFHEKTAALKLEAEGEAMEDAAAPGDDR 417
+ G + + P P KT +A+ E+ + +
Sbjct: 290 ---KTSQVGAASAPAKESPRKGAAPAP-------PGKTGPAVAKAQAGKREEDSQSSSEE 339
Query: 418 GGTQEPAPVPAEP 430
++E AP A+P
Sbjct: 340 SDSEEEAPAQAKP 352
Score = 33.1 bits (74), Expect = 0.56
Identities = 58/298 (19%), Positives = 111/298 (37%), Gaps = 44/298 (14%)
Query: 27 GLASTVSLSAESGKSEKG--QPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPS 84
G A + A++G E + S + + + + K GK + A +K
Sbjct: 774 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG 833
Query: 85 SYP-------PAVNKGRKVASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRKQG- 136
+ P P+ + K S +D P ++ +++ P + P R
Sbjct: 834 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG 893
Query: 137 -----SDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSE-VTPRVVSKGRGGLRKPEA 190
+ ++A RK + S++ SSSS+SE +D ++ +TP + R +
Sbjct: 894 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGI----RTNVVTMPT 949
Query: 191 SHSFENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKTTMP 250
+H AP+ +++ + K I+D +K P + S P+ ++P
Sbjct: 950 AH--PRIAPKASMAGASSS---KESSRISDGKKQEGPATQVSKKNPA----------SLP 994
Query: 251 RSQVDEEFLKQSLKEKQ--LQKTFRLNEIDKESQKPFEVKGPLPVHTKSGLSAPPKGS 306
+Q + L Q E Q + +T + +D G LP + S KG+
Sbjct: 995 LTQAALKVLAQKASEAQPPVARTQPSSGVD-------SAVGTLPATSPQSTSVQAKGT 1045
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 46.6 bits (109), Expect = 5e-05
Identities = 99/468 (21%), Positives = 166/468 (35%), Gaps = 64/468 (13%)
Query: 8 RQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSKKQ---SPPKNVVEPKER 64
+ A T++ E + G +A+ G GQ +S + S + VE K
Sbjct: 159 KSAEPSANTTLVSETEE-EGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKAS 217
Query: 65 GKLLATQTAAELSKNLSSPSSYPPAVNKGRKVASPSPSGSVLFTDEGVPKFLSRKTLVEF 124
K+L + A+ +K + P K VAS + +G E + S
Sbjct: 218 EKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETP 277
Query: 125 PQKVLSPFRKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGG 184
K L + G S QVG ++S+ + S + A + P V+K + G
Sbjct: 278 AAKALLQAKASGKTS---QVG------AASAPAKESPRKGAAPAPPGKTGP-AVAKAQAG 327
Query: 185 LRKPEASHSFENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSE------ 238
R+ ++ S E A+ K + P V P+K +PA P +
Sbjct: 328 KREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAA 387
Query: 239 ----GRENARPKTTMPRSQVDEEFL--KQSLKEKQLQKTFRLNEIDKESQKPF-EVKGPL 291
G++ +++ S D E L + + K L K+ ++ P + GP+
Sbjct: 388 QVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPV 447
Query: 292 P-------------------VHTKSGLSAPPKGSPAPAVL--AEEARAEGQLQASPPGA- 329
P + S S+ P + A+E LQA P +
Sbjct: 448 PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSP 507
Query: 330 AEGHLEKPVP-EPQRKAAPPLPRKETS-------GTQGIEGHLKGGQAIVEDQIPPSNLE 381
A+G +K P Q KA P+ E+S ++ + QA +IP + +
Sbjct: 508 AKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT--K 565
Query: 382 TVPVENNHGFHEKTAALKLEAE-----GEAMEDAAAPGDDRGGTQEPA 424
P + N K A +++ + G A A + GGTQ PA
Sbjct: 566 ACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA 613
Score = 41.6 bits (96), Expect = 0.002
Identities = 68/313 (21%), Positives = 110/313 (35%), Gaps = 36/313 (11%)
Query: 133 RKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASH 192
RK+ ++ +A +K S+S SS+ E + EA+ ++ TPR+ S L +
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVL-GADLPS 119
Query: 193 SFENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPK-TTMPR 251
S + +A T A KT PH P K + R++A P T
Sbjct: 120 SMKEKAKAETEKA-GKTGNSMPH--------PATGKTVANLLSGKSPRKSAEPSANTTLV 170
Query: 252 SQVDEEFLKQSLKEKQLQKTFRLNEIDKES--------QKPFEVKGPLPVHTKSGLSAPP 303
S+ +EE + + D S + EVK + SAP
Sbjct: 171 SETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPA 230
Query: 304 KGSP----APAVLAEEARAEGQLQASPP--GAAEGHLEKPVPEPQRKAAPPLPRKETSGT 357
KG+P PA + Q +A P + E E + AA L + + SG
Sbjct: 231 KGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASG- 289
Query: 358 QGIEGHLKGGQAIVEDQIPPSNLETVPVENNHGFHEKTAALKLEAEGEAMEDAAAPGDDR 417
+ G + + P P KT +A+ E+ + +
Sbjct: 290 ---KTSQVGAASAPAKESPRKGAAPAP-------PGKTGPAVAKAQAGKREEDSQSSSEE 339
Query: 418 GGTQEPAPVPAEP 430
++E AP A+P
Sbjct: 340 SDSEEEAPAQAKP 352
Score = 35.8 bits (81), Expect = 0.087
Identities = 70/378 (18%), Positives = 135/378 (35%), Gaps = 49/378 (12%)
Query: 27 GLASTVSLSAESGKSEKG--QPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPS 84
G A + A++G E + S + + + + K GK + A +K
Sbjct: 774 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG 833
Query: 85 SYP-------PAVNKGRKVASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRKQG- 136
+ P P+ + K S +D P ++ +++ P + P R
Sbjct: 834 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG 893
Query: 137 -----SDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSE---------------VTPR 176
+ ++A RK + S++ SSSS+SE +D ++ PR
Sbjct: 894 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR 953
Query: 177 VVSKG--RGGLRKPEASHSFENR---APRVTVSAKEKTLLQKPHVDI-TDPEKPHQPKKK 230
+ K G E+S + + P VS K L + +K + +
Sbjct: 954 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP 1013
Query: 231 GSPAKPSEGRENA-------RPKTTMPRSQVDEEFLKQSLKEKQ----LQKTFRLNEIDK 279
+ +PS G ++A P++T +++ + K L E Q ++ +E
Sbjct: 1014 VARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1073
Query: 280 ESQKPFEVKGPLPVHTKSGLSAPPKGSPAPAVLAEEA--RAEGQLQASPPGAAEGHLEKP 337
+S E G P KS + P S ++ E A +E + A G++
Sbjct: 1074 DSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPG 1133
Query: 338 VPEPQRKAAPPLPRKETS 355
+ +A+ P+ ++S
Sbjct: 1134 LTPANSQASKATPKLDSS 1151
>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
Length = 2968
Score = 46.6 bits (109), Expect = 5e-05
Identities = 50/214 (23%), Positives = 73/214 (34%), Gaps = 10/214 (4%)
Query: 35 SAESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPSSYPPAVNKGR 94
S S S G +S S + E +E G +N S+ SS
Sbjct: 2557 SESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASS--------- 2607
Query: 95 KVASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRKQGSDSEARQVGRKVTSPSSS 154
+ ASP+ S S + S + S S S + +S SSS
Sbjct: 2608 RAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2667
Query: 155 SSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENRAPRVTVSAKEKTLLQKP 214
SSSS++D +S +D E P + P + +A S +KT +P
Sbjct: 2668 SSSSTTDEDSSCSSD-DEAAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQP 2726
Query: 215 HVDITDPEKPHQPKKKGSPAKPSEGRENARPKTT 248
P +P QPK + + RE TT
Sbjct: 2727 QAPPPQPTQPLQPKAQAGAKSRPKKREGVHLPTT 2760
Score = 40.0 bits (92), Expect = 0.005
Identities = 61/283 (21%), Positives = 91/283 (32%), Gaps = 55/283 (19%)
Query: 78 KNLSSPSSYPPAVNKGRKVA----------SPSPSGSVLFTDEGVPKFLSRKTLVEFPQK 127
K+L S SYPPA A + P + F D G PK
Sbjct: 2496 KSLLSLGSYPPAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPK------------- 2542
Query: 128 VLSPFRKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRK 187
SP + Q A + +S S SSSSSSS S S E + E + G G +
Sbjct: 2543 --SPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGR 2600
Query: 188 PEASHSFENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKT 247
++ S +P + S+ + S + S ++ +
Sbjct: 2601 NCSAASSRAASPASSSSSSSSS-----------------SSSSSSSSSSSSSSSSSSSSS 2643
Query: 248 TMPRSQVDEEFLKQSLKEKQLQKTFRLNEIDKESQKPFEVKGPLPVHTKSGLSAPPKGSP 307
+ S S + + D++S + AP G
Sbjct: 2644 SSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSD---------DEAAPAPTAGPS 2694
Query: 308 APAVLAEEARAEGQLQASPPGAAEGHLEKPVPEPQRKAAPPLP 350
A A L +A + +A P + G K P PQ +A PP P
Sbjct: 2695 AQAALPTKATKQAG-KARPSAHSPG---KKTPAPQPQAPPPQP 2733
Score = 39.7 bits (91), Expect = 0.006
Identities = 49/199 (24%), Positives = 69/199 (34%), Gaps = 13/199 (6%)
Query: 61 PKERGKLLATQTAAELSKNLSSPSSYPPAVNKGRKVASPSPSGSVLFTDEGVPKF----- 115
PK K A Q AE S++ SS SS +S S SGS +E K
Sbjct: 2541 PKSPDKAQAEQDGAEESESSSSSSS-----GSSSSSSSSSSSGSETEGEEEGDKNGDGGC 2595
Query: 116 -LSRKTLVEFPQKVLSPFRKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVT 174
+ + SP S S + +S SSSSSSSSS S S + S +
Sbjct: 2596 GTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2655
Query: 175 PRVVSKGRGGLRKPEASHSFENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPA 234
S ++ ++ +A T P P K + K P+
Sbjct: 2656 SSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPT--AGPSAQAALPTKATKQAGKARPS 2713
Query: 235 KPSEGRENARPKTTMPRSQ 253
S G++ P+ P Q
Sbjct: 2714 AHSPGKKTPAPQPQAPPPQ 2732
Score = 29.6 bits (65), Expect = 6.2
Identities = 22/86 (25%), Positives = 35/86 (40%), Gaps = 9/86 (10%)
Query: 27 GLASTVSLSAESGKSEKGQPQNSKKQSPPKNVVEPKERG----KLLATQTAAELSKNLSS 82
GLA V L A+ + P++ + P + EP G L + AE+
Sbjct: 1109 GLAPDVPLPADGPERLALSPEDKPIRLSPSKITEPLREGPEEEPLAEREVKAEVEDMDEG 1168
Query: 83 PSSYPP-----AVNKGRKVASPSPSG 103
P+ PP + +A+PSP+G
Sbjct: 1169 PTELPPLESPLPLPAAEAMATPSPAG 1194
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 46.2 bits (108), Expect = 6e-05
Identities = 94/436 (21%), Positives = 158/436 (36%), Gaps = 62/436 (14%)
Query: 37 ESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPSSYPPAVNKGRKV 96
ES SE+G S++++P + K K+L + A+ +K + P K V
Sbjct: 269 ESESSEEGS--ESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326
Query: 97 ASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRKQGSDSEARQVGRKVTSPSSSSS 156
AS + +G E + S K L + G S QVG ++S+
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTS---QVG------AASAP 377
Query: 157 SSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENRAPRVTVSAKEKTLLQKPHV 216
+ S + A + P V+K + G R+ ++ S E A+ K + P V
Sbjct: 378 AKESPRKGAAPAPPGKTGP-AVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 436
Query: 217 DITDPEKPHQPKKKGSPAKPSE----------GRENARPKTTMPRSQVDEEFL--KQSLK 264
P+K +PA P + G++ +++ S D E L + +
Sbjct: 437 RAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQ 496
Query: 265 EKQLQKTFRLNEIDKESQKPF-EVKGPLP-------------------VHTKSGLSAPPK 304
K L K+ ++ P + GP+P + S S+
Sbjct: 497 VKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSS 556
Query: 305 GSPAPAVL--AEEARAEGQLQASPPGA-AEGHLEKPVP-EPQRKAAPPLPRKETS----- 355
P + A+E LQA P + A+G +K P Q KA P+ E+S
Sbjct: 557 DGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 356 --GTQGIEGHLKGGQAIVEDQIPPSNLETVPVENNHGFHEKTAALKLEAE-----GEAME 408
++ + QA +IP + + P + N K A +++ + G A
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQT--KACPKKTNTTASAKVAPVRVGTQAPRKAGTATS 674
Query: 409 DAAAPGDDRGGTQEPA 424
A + GGTQ PA
Sbjct: 675 PAGSSPAVAGGTQRPA 690
Score = 43.1 bits (100), Expect = 5e-04
Identities = 73/335 (21%), Positives = 123/335 (36%), Gaps = 41/335 (12%)
Query: 133 RKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASH 192
RK+ ++ +A +K S+S SS+ E + EA+ ++ TPR+ S L S
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
Query: 193 SFENRAPRVTVSAKEKTLLQKPHVDIT--------DPEKPHQPKKK-------------- 230
E + K + P T P K +P
Sbjct: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
Query: 231 --GSPAKP---SEGRENARPKTTMPRSQVDEEFLKQSLKEKQLQK---TFRLNEIDKESQ 282
G+ AKP S G+ ++ + T S + K S+K Q++ + + + K +
Sbjct: 181 AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP 240
Query: 283 KPFEVKGPLPVHTKSGLSAPPKGSPAPAVLAEEARAEGQLQASPPGAAEGHLEKPVPEPQ 342
P +V G + K G P K + P +E + + + P ++ Q
Sbjct: 241 APGKV-GDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQ 299
Query: 343 RKAAPPLPRKETSGTQGIEGHLKGGQAIVEDQI----PPSNLETVPVENNHGFHEKTAA- 397
+AA P K T G +G G V Q P + E+ E++ E AA
Sbjct: 300 VRAA-SAPAKGTPG-KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAK 357
Query: 398 --LKLEAEGEAMEDAAAPGDDRGGTQEPAPVPAEP 430
L+ +A G+ + AA + ++ A PA P
Sbjct: 358 ALLQAKASGKTSQVGAASAPAKESPRKGA-APAPP 391
Score = 32.3 bits (72), Expect = 0.96
Identities = 67/356 (18%), Positives = 129/356 (36%), Gaps = 42/356 (11%)
Query: 27 GLASTVSLSAESGKSEKG--QPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPS 84
G A + A++G E + S + + + + K GK + A +K
Sbjct: 851 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG 910
Query: 85 SYP-------PAVNKGRKVASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRKQG- 136
+ P P+ + K S +D P ++ +++ P + P R
Sbjct: 911 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG 970
Query: 137 -----SDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSE-VTPRVVSKGRGGLRKPEA 190
+ ++A RK + S++ SSSS+SE +D ++ +TP + R +
Sbjct: 971 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGI----RTNVVTMPT 1026
Query: 191 SHSFENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKTTMP 250
+H AP+ +++ + K I+D KK+ PA + P T+
Sbjct: 1027 AH--PRIAPKASMAGASSS---KESSRISD------GKKQEGPATQVDSAVGTLPATSPQ 1075
Query: 251 RSQVDEEFLKQSLKEK--QLQKTFRL------NEIDKESQKPFEVKGPLPVHTKSGLSAP 302
+ V + + K K ++Q+ + +E +S E G P KS +
Sbjct: 1076 STSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLV 1135
Query: 303 PKGSPAPAVLAEEARAEG---QLQASPPGAAEGHLEKPVPEPQRKAAPPLPRKETS 355
L EE AE + A G++ + +A+ P+ ++S
Sbjct: 1136 GPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSS 1191
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 46.2 bits (108), Expect = 6e-05
Identities = 94/436 (21%), Positives = 158/436 (36%), Gaps = 62/436 (14%)
Query: 37 ESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPSSYPPAVNKGRKV 96
ES SE+G S++++P + K K+L + A+ +K + P K V
Sbjct: 269 ESESSEEGS--ESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326
Query: 97 ASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRKQGSDSEARQVGRKVTSPSSSSS 156
AS + +G E + S K L + G S QVG ++S+
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTS---QVG------AASAP 377
Query: 157 SSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENRAPRVTVSAKEKTLLQKPHV 216
+ S + A + P V+K + G R+ ++ S E A+ K + P V
Sbjct: 378 AKESPRKGAAPAPPGKTGP-AVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 436
Query: 217 DITDPEKPHQPKKKGSPAKPSE----------GRENARPKTTMPRSQVDEEFL--KQSLK 264
P+K +PA P + G++ +++ S D E L + +
Sbjct: 437 RAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQ 496
Query: 265 EKQLQKTFRLNEIDKESQKPF-EVKGPLP-------------------VHTKSGLSAPPK 304
K L K+ ++ P + GP+P + S S+
Sbjct: 497 VKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSS 556
Query: 305 GSPAPAVL--AEEARAEGQLQASPPGA-AEGHLEKPVP-EPQRKAAPPLPRKETS----- 355
P + A+E LQA P + A+G +K P Q KA P+ E+S
Sbjct: 557 DGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 356 --GTQGIEGHLKGGQAIVEDQIPPSNLETVPVENNHGFHEKTAALKLEAE-----GEAME 408
++ + QA +IP + + P + N K A +++ + G A
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQT--KACPKKTNTTASAKVAPVRVGTQAPRKAGTATS 674
Query: 409 DAAAPGDDRGGTQEPA 424
A + GGTQ PA
Sbjct: 675 PAGSSPAVAGGTQRPA 690
Score = 43.1 bits (100), Expect = 5e-04
Identities = 73/335 (21%), Positives = 123/335 (36%), Gaps = 41/335 (12%)
Query: 133 RKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASH 192
RK+ ++ +A +K S+S SS+ E + EA+ ++ TPR+ S L S
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
Query: 193 SFENRAPRVTVSAKEKTLLQKPHVDIT--------DPEKPHQPKKK-------------- 230
E + K + P T P K +P
Sbjct: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
Query: 231 --GSPAKP---SEGRENARPKTTMPRSQVDEEFLKQSLKEKQLQK---TFRLNEIDKESQ 282
G+ AKP S G+ ++ + T S + K S+K Q++ + + + K +
Sbjct: 181 AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP 240
Query: 283 KPFEVKGPLPVHTKSGLSAPPKGSPAPAVLAEEARAEGQLQASPPGAAEGHLEKPVPEPQ 342
P +V G + K G P K + P +E + + + P ++ Q
Sbjct: 241 APGKV-GDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQ 299
Query: 343 RKAAPPLPRKETSGTQGIEGHLKGGQAIVEDQI----PPSNLETVPVENNHGFHEKTAA- 397
+AA P K T G +G G V Q P + E+ E++ E AA
Sbjct: 300 VRAA-SAPAKGTPG-KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAK 357
Query: 398 --LKLEAEGEAMEDAAAPGDDRGGTQEPAPVPAEP 430
L+ +A G+ + AA + ++ A PA P
Sbjct: 358 ALLQAKASGKTSQVGAASAPAKESPRKGA-APAPP 391
Score = 35.8 bits (81), Expect = 0.087
Identities = 70/378 (18%), Positives = 135/378 (35%), Gaps = 49/378 (12%)
Query: 27 GLASTVSLSAESGKSEKG--QPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPS 84
G A + A++G E + S + + + + K GK + A +K
Sbjct: 851 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG 910
Query: 85 SYP-------PAVNKGRKVASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRKQG- 136
+ P P+ + K S +D P ++ +++ P + P R
Sbjct: 911 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG 970
Query: 137 -----SDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSE---------------VTPR 176
+ ++A RK + S++ SSSS+SE +D ++ PR
Sbjct: 971 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR 1030
Query: 177 VVSKG--RGGLRKPEASHSFENR---APRVTVSAKEKTLLQKPHVDI-TDPEKPHQPKKK 230
+ K G E+S + + P VS K L + +K + +
Sbjct: 1031 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPP 1090
Query: 231 GSPAKPSEGRENA-------RPKTTMPRSQVDEEFLKQSLKEKQ----LQKTFRLNEIDK 279
+ +PS G ++A P++T +++ + K L E Q ++ +E
Sbjct: 1091 VARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1150
Query: 280 ESQKPFEVKGPLPVHTKSGLSAPPKGSPAPAVLAEEA--RAEGQLQASPPGAAEGHLEKP 337
+S E G P KS + P S ++ E A +E + A G++
Sbjct: 1151 DSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPG 1210
Query: 338 VPEPQRKAAPPLPRKETS 355
+ +A+ P+ ++S
Sbjct: 1211 LTPANSQASKATPKLDSS 1228
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 46.2 bits (108), Expect = 6e-05
Identities = 94/436 (21%), Positives = 158/436 (36%), Gaps = 62/436 (14%)
Query: 37 ESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPSSYPPAVNKGRKV 96
ES SE+G S++++P + K K+L + A+ +K + P K V
Sbjct: 269 ESESSEEGS--ESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326
Query: 97 ASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRKQGSDSEARQVGRKVTSPSSSSS 156
AS + +G E + S K L + G S QVG ++S+
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTS---QVG------AASAP 377
Query: 157 SSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENRAPRVTVSAKEKTLLQKPHV 216
+ S + A + P V+K + G R+ ++ S E A+ K + P V
Sbjct: 378 AKESPRKGAAPAPPGKTGP-AVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 436
Query: 217 DITDPEKPHQPKKKGSPAKPSE----------GRENARPKTTMPRSQVDEEFL--KQSLK 264
P+K +PA P + G++ +++ S D E L + +
Sbjct: 437 RAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQ 496
Query: 265 EKQLQKTFRLNEIDKESQKPF-EVKGPLP-------------------VHTKSGLSAPPK 304
K L K+ ++ P + GP+P + S S+
Sbjct: 497 VKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSS 556
Query: 305 GSPAPAVL--AEEARAEGQLQASPPGA-AEGHLEKPVP-EPQRKAAPPLPRKETS----- 355
P + A+E LQA P + A+G +K P Q KA P+ E+S
Sbjct: 557 DGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 356 --GTQGIEGHLKGGQAIVEDQIPPSNLETVPVENNHGFHEKTAALKLEAE-----GEAME 408
++ + QA +IP + + P + N K A +++ + G A
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQT--KACPKKTNTTASAKVAPVRVGTQAPRKAGTATS 674
Query: 409 DAAAPGDDRGGTQEPA 424
A + GGTQ PA
Sbjct: 675 PAGSSPAVAGGTQRPA 690
Score = 43.1 bits (100), Expect = 5e-04
Identities = 73/335 (21%), Positives = 123/335 (36%), Gaps = 41/335 (12%)
Query: 133 RKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASH 192
RK+ ++ +A +K S+S SS+ E + EA+ ++ TPR+ S L S
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
Query: 193 SFENRAPRVTVSAKEKTLLQKPHVDIT--------DPEKPHQPKKK-------------- 230
E + K + P T P K +P
Sbjct: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
Query: 231 --GSPAKP---SEGRENARPKTTMPRSQVDEEFLKQSLKEKQLQK---TFRLNEIDKESQ 282
G+ AKP S G+ ++ + T S + K S+K Q++ + + + K +
Sbjct: 181 AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP 240
Query: 283 KPFEVKGPLPVHTKSGLSAPPKGSPAPAVLAEEARAEGQLQASPPGAAEGHLEKPVPEPQ 342
P +V G + K G P K + P +E + + + P ++ Q
Sbjct: 241 APGKV-GDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQ 299
Query: 343 RKAAPPLPRKETSGTQGIEGHLKGGQAIVEDQI----PPSNLETVPVENNHGFHEKTAA- 397
+AA P K T G +G G V Q P + E+ E++ E AA
Sbjct: 300 VRAA-SAPAKGTPG-KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAK 357
Query: 398 --LKLEAEGEAMEDAAAPGDDRGGTQEPAPVPAEP 430
L+ +A G+ + AA + ++ A PA P
Sbjct: 358 ALLQAKASGKTSQVGAASAPAKESPRKGA-APAPP 391
Score = 35.0 bits (79), Expect = 0.15
Identities = 67/355 (18%), Positives = 132/355 (37%), Gaps = 41/355 (11%)
Query: 27 GLASTVSLSAESGKSEKG--QPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPS 84
G A + A++G E + S + + + + K GK + A +K
Sbjct: 851 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG 910
Query: 85 SYP-------PAVNKGRKVASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRKQG- 136
+ P P+ + K S +D P ++ +++ P + P R
Sbjct: 911 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG 970
Query: 137 -----SDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSE-VTPRVVSKGRGGLRKPEA 190
+ ++A RK + S++ SSSS+SE +D ++ +TP + R +
Sbjct: 971 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGI----RTNVVTMPT 1026
Query: 191 SHSFENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKTTMP 250
+H AP+ +++ + K I+D KK+ PA + P T+
Sbjct: 1027 AH--PRIAPKASMAGASSS---KESSRISD------GKKQEGPATQVDSAVGTLPATSPQ 1075
Query: 251 RSQVDEEFLKQSLKEK--QLQKTFRL------NEIDKESQKPFEVKGPLPVHTKSGLSAP 302
+ V + + K K ++Q+ + +E +S E G P KS +
Sbjct: 1076 STSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLG 1135
Query: 303 PKGSPAPAVLAEEA--RAEGQLQASPPGAAEGHLEKPVPEPQRKAAPPLPRKETS 355
P S ++ E A +E + A G++ + +A+ P+ ++S
Sbjct: 1136 PTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSS 1190
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 46.2 bits (108), Expect = 6e-05
Identities = 94/436 (21%), Positives = 158/436 (36%), Gaps = 62/436 (14%)
Query: 37 ESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPSSYPPAVNKGRKV 96
ES SE+G S++++P + K K+L + A+ +K + P K V
Sbjct: 269 ESESSEEGS--ESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326
Query: 97 ASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRKQGSDSEARQVGRKVTSPSSSSS 156
AS + +G E + S K L + G S QVG ++S+
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTS---QVG------AASAP 377
Query: 157 SSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENRAPRVTVSAKEKTLLQKPHV 216
+ S + A + P V+K + G R+ ++ S E A+ K + P V
Sbjct: 378 AKESPRKGAAPAPPGKTGP-AVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 436
Query: 217 DITDPEKPHQPKKKGSPAKPSE----------GRENARPKTTMPRSQVDEEFL--KQSLK 264
P+K +PA P + G++ +++ S D E L + +
Sbjct: 437 RAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQ 496
Query: 265 EKQLQKTFRLNEIDKESQKPF-EVKGPLP-------------------VHTKSGLSAPPK 304
K L K+ ++ P + GP+P + S S+
Sbjct: 497 VKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSS 556
Query: 305 GSPAPAVL--AEEARAEGQLQASPPGA-AEGHLEKPVP-EPQRKAAPPLPRKETS----- 355
P + A+E LQA P + A+G +K P Q KA P+ E+S
Sbjct: 557 DGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 356 --GTQGIEGHLKGGQAIVEDQIPPSNLETVPVENNHGFHEKTAALKLEAE-----GEAME 408
++ + QA +IP + + P + N K A +++ + G A
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQT--KACPKKTNTTASAKVAPVRVGTQAPRKAGTATS 674
Query: 409 DAAAPGDDRGGTQEPA 424
A + GGTQ PA
Sbjct: 675 PAGSSPAVAGGTQRPA 690
Score = 43.1 bits (100), Expect = 5e-04
Identities = 73/335 (21%), Positives = 123/335 (36%), Gaps = 41/335 (12%)
Query: 133 RKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASH 192
RK+ ++ +A +K S+S SS+ E + EA+ ++ TPR+ S L S
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
Query: 193 SFENRAPRVTVSAKEKTLLQKPHVDIT--------DPEKPHQPKKK-------------- 230
E + K + P T P K +P
Sbjct: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
Query: 231 --GSPAKP---SEGRENARPKTTMPRSQVDEEFLKQSLKEKQLQK---TFRLNEIDKESQ 282
G+ AKP S G+ ++ + T S + K S+K Q++ + + + K +
Sbjct: 181 AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP 240
Query: 283 KPFEVKGPLPVHTKSGLSAPPKGSPAPAVLAEEARAEGQLQASPPGAAEGHLEKPVPEPQ 342
P +V G + K G P K + P +E + + + P ++ Q
Sbjct: 241 APGKV-GDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQ 299
Query: 343 RKAAPPLPRKETSGTQGIEGHLKGGQAIVEDQI----PPSNLETVPVENNHGFHEKTAA- 397
+AA P K T G +G G V Q P + E+ E++ E AA
Sbjct: 300 VRAA-SAPAKGTPG-KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAK 357
Query: 398 --LKLEAEGEAMEDAAAPGDDRGGTQEPAPVPAEP 430
L+ +A G+ + AA + ++ A PA P
Sbjct: 358 ALLQAKASGKTSQVGAASAPAKESPRKGA-APAPP 391
Score = 36.6 bits (83), Expect = 0.051
Identities = 43/185 (23%), Positives = 77/185 (41%), Gaps = 20/185 (10%)
Query: 11 RAGALKTMLQEAQVFRGL-ASTVSLSAESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLA 69
+ G T+ Q V +GL S+ + + P K P V+ +++ +
Sbjct: 705 KTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSES 764
Query: 70 TQTAAELSKNLSSPSSYPPAVNKGRKVASPS----PSGSVLFTDEGVPKFLSRKTLVEFP 125
++ ++ + +SP+ +V K + A+P+ PS + G + + P
Sbjct: 765 SEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSP 824
Query: 126 QKVLSPFRK-QGSDSEAR------QVGRKV-------TSPSSSSSSSSSDSESDDEAD-V 170
KV P R Q S AR VG+ V T P S SS +S+S++EA+ +
Sbjct: 825 SKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETL 884
Query: 171 SEVTP 175
++V P
Sbjct: 885 AQVKP 889
>gi|51317366 myosin XVIIIB [Homo sapiens]
Length = 2567
Score = 45.8 bits (107), Expect = 8e-05
Identities = 89/384 (23%), Positives = 143/384 (37%), Gaps = 40/384 (10%)
Query: 16 KTMLQEAQVFRG--LASTVSLSAESGKSEKGQPQNSK--KQSPPKNVVEPKERGKLLATQ 71
KT+ + V RG L L +S K EK P ++ K SPP +++G+ T
Sbjct: 140 KTVPFKRGVRRGDVLLMVAKLDPDSAKPEKTHPHDAPPCKTSPPATDTGKEKKGETSRTP 199
Query: 72 TAAELSKNLSSPSSYPPAVNKGRKVASPSPSGSVLFTDEG------VPKFLSRKTLVEFP 125
++ S + +P + K R P + +G V K L E
Sbjct: 200 CGSQASTEILAPKA-----EKTRTGGLGDPGQGTVALKKGEEGQSIVGKGLGTPKTTELK 254
Query: 126 QKVLSPFRKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSE--------VTPRV 177
+ +QG+ +A+ G V P + + + + ++ +VS+ V P++
Sbjct: 255 EAEPQGKDRQGTRPQAQGPGEGVR-PGKAEKEGAEPTNTVEKGNVSKDVGSEGKHVRPQI 313
Query: 178 VSKGRGG-LRKPEASHSFENRAPR--VTVSAKEKTLLQKPHVDITDPEKPHQPKKK-GSP 233
+ GG L + +N+ + V +S EKT +P T EK Q + + G
Sbjct: 314 PGRKWGGFLGRRSKWDGPQNKKDKEGVLLSKAEKT--GEPQ---TQMEKTSQVQGELGDD 368
Query: 234 AKPSEGRENARPKTTMPRSQVDEEFLKQSLKEKQLQKTFRLNEIDKESQKPFEVKGPLPV 293
+ E R T + E + K+ + K+ E +++K E P V
Sbjct: 369 LRMGEKAGELRSTT----GKAGESWDKKEKMGQPQGKSGNAGEARSQTEKGCEA--PKEV 422
Query: 294 HTKSGLSAPPKGSPAPAVLAEEARAEGQLQASPPGAAEGHLEKPV-PEPQRKAAPPLPRK 352
T A P P +EA GA E LE P P ++ A P RK
Sbjct: 423 STMVESPAAPGKGGWPGSRGQEAEEPCSRAGDGAGALETELEGPSQPALEKDAERPRIRK 482
Query: 353 ETSGTQGIEGHLKGGQAIVEDQIP 376
E + KGGQ+ DQ P
Sbjct: 483 ENQDGPAPQEEGKGGQSRDSDQAP 506
Score = 32.3 bits (72), Expect = 0.96
Identities = 57/259 (22%), Positives = 87/259 (33%), Gaps = 43/259 (16%)
Query: 150 SPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENRAPRV-----TVS 204
S SSS + S S S D+ S + ++ K G R P+ + + +
Sbjct: 77 SKSSSGTRSGSQQISQDDQSSSPGSSDILGKESEGSRSPDPEQMTSINGEKAQELGSSAT 136
Query: 205 AKEKT--------------LLQKPHVDITDPEKPH---QPKKKGSPAKPSEGRENARPKT 247
+KT ++ K D PEK H P K SP G+E +
Sbjct: 137 PTKKTVPFKRGVRRGDVLLMVAKLDPDSAKPEKTHPHDAPPCKTSPPATDTGKEKKGETS 196
Query: 248 TMP-RSQVDEEFLKQSLKEKQL-------QKTFRLNEIDK---------ESQKPFEVKGP 290
P SQ E L ++ + Q T L + ++ + K E+K
Sbjct: 197 RTPCGSQASTEILAPKAEKTRTGGLGDPGQGTVALKKGEEGQSIVGKGLGTPKTTELKEA 256
Query: 291 LPVHTKSGLSAPPKGSPAPAVLAEEARAEGQLQASPPGAAE-GHLEKPVPEPQRKAAPPL 349
P + P P V +A EG A P E G++ K V + P +
Sbjct: 257 EPQGKDRQGTRPQAQGPGEGVRPGKAEKEG---AEPTNTVEKGNVSKDVGSEGKHVRPQI 313
Query: 350 PRKETSGTQGIEGHLKGGQ 368
P ++ G G G Q
Sbjct: 314 PGRKWGGFLGRRSKWDGPQ 332
>gi|224451082 cytospin A [Homo sapiens]
Length = 1117
Score = 45.4 bits (106), Expect = 1e-04
Identities = 75/323 (23%), Positives = 132/323 (40%), Gaps = 22/323 (6%)
Query: 27 GLASTVSLSAESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPSSY 86
G VS +++ +EK +P+NS S +V+P L T+++ +L ++ +
Sbjct: 9 GSVPKVSAISKTQTAEKIKPENSSSASTGGKLVKPGTAASLSKTKSSDDLLAGMAGGVTV 68
Query: 87 PPAVNKGRK----VASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRKQGSDSEAR 142
V KG+K A+PS S + T E K +S T ++ S K+ S + R
Sbjct: 69 TNGV-KGKKSTCPSAAPSASAPAMTTVENKSK-ISTGT-ASSTKRSTSTGNKESSSTRER 125
Query: 143 QVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENRAPRVT 202
R+ T + S S+ ++D A R ++ + K ++ + +RA
Sbjct: 126 L--RERTRLNQSKKLPSAGQGANDMALAKRSRSRTATECDVRMSKSKSDNQISDRA---A 180
Query: 203 VSAKEK---TLLQKPHVDITD--PEKPHQPKKKGSPAKPSEGRENARPKTTMPRSQVDEE 257
+ AK K TL + V+I E + G SEG E + +T M D E
Sbjct: 181 LEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSEGDEKSEKETIMAHQPTDVE 240
Query: 258 FLKQSLKEKQLQKTFRLNEIDKESQKPFEVKGPLPVHTKSGLSAPPK----GSPAPAVLA 313
L+E+ LN++ E++ + L + L K S +P +
Sbjct: 241 STLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITP 300
Query: 314 E-EARAEGQLQASPPGAAEGHLE 335
+ ++ G L +S G+A G +E
Sbjct: 301 DNQSDGGGTLTSSVEGSAPGSVE 323
>gi|224451080 cytospin A [Homo sapiens]
Length = 1117
Score = 45.4 bits (106), Expect = 1e-04
Identities = 75/323 (23%), Positives = 132/323 (40%), Gaps = 22/323 (6%)
Query: 27 GLASTVSLSAESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPSSY 86
G VS +++ +EK +P+NS S +V+P L T+++ +L ++ +
Sbjct: 9 GSVPKVSAISKTQTAEKIKPENSSSASTGGKLVKPGTAASLSKTKSSDDLLAGMAGGVTV 68
Query: 87 PPAVNKGRK----VASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRKQGSDSEAR 142
V KG+K A+PS S + T E K +S T ++ S K+ S + R
Sbjct: 69 TNGV-KGKKSTCPSAAPSASAPAMTTVENKSK-ISTGT-ASSTKRSTSTGNKESSSTRER 125
Query: 143 QVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENRAPRVT 202
R+ T + S S+ ++D A R ++ + K ++ + +RA
Sbjct: 126 L--RERTRLNQSKKLPSAGQGANDMALAKRSRSRTATECDVRMSKSKSDNQISDRA---A 180
Query: 203 VSAKEK---TLLQKPHVDITD--PEKPHQPKKKGSPAKPSEGRENARPKTTMPRSQVDEE 257
+ AK K TL + V+I E + G SEG E + +T M D E
Sbjct: 181 LEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSEGDEKSEKETIMAHQPTDVE 240
Query: 258 FLKQSLKEKQLQKTFRLNEIDKESQKPFEVKGPLPVHTKSGLSAPPK----GSPAPAVLA 313
L+E+ LN++ E++ + L + L K S +P +
Sbjct: 241 STLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITP 300
Query: 314 E-EARAEGQLQASPPGAAEGHLE 335
+ ++ G L +S G+A G +E
Sbjct: 301 DNQSDGGGTLTSSVEGSAPGSVE 323
>gi|27734775 hypothetical protein LOC286499 [Homo sapiens]
Length = 248
Score = 45.1 bits (105), Expect = 1e-04
Identities = 47/186 (25%), Positives = 83/186 (44%), Gaps = 14/186 (7%)
Query: 118 RKTLVEFPQKVLSPFRKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRV 177
+K L + +K+LS E ++ +K + SSSSSSSS S S +++ E
Sbjct: 70 KKELEKSREKLLSGNESSSKKRERKKKRKKKSCRSSSSSSSSDSSSSSSDSEDEE----- 124
Query: 178 VSKGRGGLRKPEASHSFENRAPRVTVS---AKEKTLLQKPHVDITDPEKPHQPKKKGSPA 234
K +G RK + + S+++ S +KE +K D T+ EK + K
Sbjct: 125 --KKQGKRRKKKKNRSYKSSQSSTHESESESKESVKKKKKSKDETEKEKDVRSLSK---- 178
Query: 235 KPSEGRENARPKTTMPRSQVDEEFLKQSLKEKQLQKTFRLNEIDKESQKPFEVKGPLPVH 294
K + + +P ++ S+ D E Q+ K+++ ++ + E K+ +K K
Sbjct: 179 KRKKSYPDDKPLSSESSSESDYEEDVQAKKKRRCEEREQAKEKVKKKKKKQHKKHSKKKK 238
Query: 295 TKSGLS 300
KSG S
Sbjct: 239 KKSGSS 244
>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
Length = 1012
Score = 44.7 bits (104), Expect = 2e-04
Identities = 63/280 (22%), Positives = 106/280 (37%), Gaps = 42/280 (15%)
Query: 138 DSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENR 197
+ + R GR SPS++S+SS+ + +V S + R+ E S
Sbjct: 49 NEDIRSSGRN--SPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEE 106
Query: 198 APRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKT---------- 247
A R T S K KT +I+ P P + + + S ++ ++ PK
Sbjct: 107 ADR-TSSKKTKTQ------EISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSP 159
Query: 248 TMPRSQVDEEFLKQSLKEKQLQKTFRLNEIDK------ESQKPFEVKGPLPVHTKSGLSA 301
++P Q +E S +++ LQ + S P + P P T S +
Sbjct: 160 SIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAV 219
Query: 302 PPKGSPAPAVLAEEARAEGQLQASPPGAAEGHLEK---------PVPEPQRKAAPPLPRK 352
PP+GSP ++A Q QA H+++ P P P +P P +
Sbjct: 220 PPQGSPT------ASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQ 273
Query: 353 ETSGTQGIEGHLKGGQAIVEDQIPPS--NLETVPVENNHG 390
+G+ G Q + Q PP +L+ P+ + G
Sbjct: 274 PLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPG 313
>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
Length = 1566
Score = 44.7 bits (104), Expect = 2e-04
Identities = 63/280 (22%), Positives = 106/280 (37%), Gaps = 42/280 (15%)
Query: 138 DSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENR 197
+ + R GR SPS++S+SS+ + +V S + R+ E S
Sbjct: 603 NEDIRSSGRN--SPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEE 660
Query: 198 APRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKT---------- 247
A R T S K KT +I+ P P + + + S ++ ++ PK
Sbjct: 661 ADR-TSSKKTKTQ------EISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSP 713
Query: 248 TMPRSQVDEEFLKQSLKEKQLQKTFRLNEIDK------ESQKPFEVKGPLPVHTKSGLSA 301
++P Q +E S +++ LQ + S P + P P T S +
Sbjct: 714 SIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAV 773
Query: 302 PPKGSPAPAVLAEEARAEGQLQASPPGAAEGHLEK---------PVPEPQRKAAPPLPRK 352
PP+GSP ++A Q QA H+++ P P P +P P +
Sbjct: 774 PPQGSPT------ASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQ 827
Query: 353 ETSGTQGIEGHLKGGQAIVEDQIPPS--NLETVPVENNHG 390
+G+ G Q + Q PP +L+ P+ + G
Sbjct: 828 PLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPG 867
>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
Length = 1566
Score = 44.7 bits (104), Expect = 2e-04
Identities = 63/280 (22%), Positives = 106/280 (37%), Gaps = 42/280 (15%)
Query: 138 DSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHSFENR 197
+ + R GR SPS++S+SS+ + +V S + R+ E S
Sbjct: 603 NEDIRSSGRN--SPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEE 660
Query: 198 APRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKT---------- 247
A R T S K KT +I+ P P + + + S ++ ++ PK
Sbjct: 661 ADR-TSSKKTKTQ------EISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSP 713
Query: 248 TMPRSQVDEEFLKQSLKEKQLQKTFRLNEIDK------ESQKPFEVKGPLPVHTKSGLSA 301
++P Q +E S +++ LQ + S P + P P T S +
Sbjct: 714 SIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAV 773
Query: 302 PPKGSPAPAVLAEEARAEGQLQASPPGAAEGHLEK---------PVPEPQRKAAPPLPRK 352
PP+GSP ++A Q QA H+++ P P P +P P +
Sbjct: 774 PPQGSPT------ASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQ 827
Query: 353 ETSGTQGIEGHLKGGQAIVEDQIPPS--NLETVPVENNHG 390
+G+ G Q + Q PP +L+ P+ + G
Sbjct: 828 PLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPG 867
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 44.7 bits (104), Expect = 2e-04
Identities = 84/387 (21%), Positives = 140/387 (36%), Gaps = 33/387 (8%)
Query: 56 KNVVEPKERGKLLATQTAAELSKNLSSPSSYPPAVNKGRKVASPSPSGSVLFTDEGVPKF 115
KN PK GK+L ++ SSP+++ + + + S V+F D K
Sbjct: 20 KNGSVPKSPGKVLKRTVTEDIVTTFSSPAAWLLVI---ALIITWSAVAIVMF-DLVDYKN 75
Query: 116 LSRKTLVEFPQKVLSPFRKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTP 175
S ++ + L R ++ G SS D + D++ D E+
Sbjct: 76 FSASSIAKIGSDPLKLVRDAMEETTDWIYGFFSLLSDIISSEDEEDDDGDEDTDKGEIDE 135
Query: 176 RVVSKGRGGLRKPEASHSFENRAPRVTVSAKEKTLLQKPHVDITDPEKP-----HQPK-- 228
+ K K E E R + V+ KEK +K + + EKP H+ K
Sbjct: 136 PPLRKKEIHKDKTEKQEKPE-RKIQTKVTHKEK---EKGKEKVREKEKPEKKATHKEKIE 191
Query: 229 KKGSPAKPSEGRENARPKTTMPRSQVDEEFLKQSLKEKQLQKTFRLNEIDKESQKPFE-- 286
KK P + +E + KT + ++ +K +EK Q ++ E+ K KP E
Sbjct: 192 KKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKE 251
Query: 287 --VKGPLPVHTKSGLSAPPKGSPAPAVLAEEARAEGQLQASPPGAAEGHLEKPVPEPQRK 344
K + H + A + + GQ A PP +P P
Sbjct: 252 DKEKAAVSKHEQKDQYAFCR--YMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTP----- 304
Query: 345 AAPPLPRKETSGTQG-----IEGHLKGGQAIVEDQIPPSNLETVPVENNHGFHEKTAALK 399
A+P L KE + E K + I + + ++ E K +K
Sbjct: 305 ASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVK 364
Query: 400 LEAEGEAMEDAAAPGDDRGGTQEPAPV 426
+ A+ A +D +D T++PA V
Sbjct: 365 IAAQAAAKKDEKK--EDSKKTKKPAEV 389
Score = 44.7 bits (104), Expect = 2e-04
Identities = 57/279 (20%), Positives = 114/279 (40%), Gaps = 36/279 (12%)
Query: 82 SPSSYPPAVNKGRKVASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRKQGSDSEA 141
SP+ PP + + + P+P+ L EG K +K E +K +K+ A
Sbjct: 287 SPAIPPPLPTE--QASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETA 344
Query: 142 RQVGRKVTSPSSSSS------SSSSDSESDDEADVSEVT--PRVVSKGRGGLRKPEASHS 193
V +K +S + ++ + ++ D++ + S+ T P V + +G ++ + H
Sbjct: 345 IDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHV 404
Query: 194 FENRAPRVTVSAKEKTLLQKPHVDITDPEKPHQPKKKGSPAKPSEGRENARPKTTMPRSQ 253
++P+ K H +D Q K K AK G + + + +
Sbjct: 405 EPAKSPK------------KEHSVPSDK----QVKAKTERAKEEIGAVSIKKAVPGKKEE 448
Query: 254 VDEEFLKQSLKEKQLQKTFRLNEIDKESQKPFEVKGPLPVHTKSGLSAPPKGSPAPAVLA 313
+ ++Q +++++ KT + + DKE K E K P + K P
Sbjct: 449 KTTKTVEQEIRKEKSGKTSSILK-DKEPIKGKEEKVPASLKEKE---------PETKKDE 498
Query: 314 EEARAEGQLQASPPGAAEGHLEKPVPEPQRKAAPPLPRK 352
+ ++A +++ PP EKP P+ +++A P + K
Sbjct: 499 KMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEK 537
Score = 38.5 bits (88), Expect = 0.013
Identities = 63/300 (21%), Positives = 108/300 (36%), Gaps = 47/300 (15%)
Query: 31 TVSLSAESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLSSPSSYPPAV 90
TV ++A++ + + ++SKK P V +PK + K + E +K+ S P
Sbjct: 362 TVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGK-KQEKKEKHVEPAKSPKKEHSVPSDK 420
Query: 91 NKGRKVASPSPSGSVLFTDEGVPKFLSRKTLVEFPQKVLSPFRKQGSDSEARQVGRKVTS 150
K + + VP KT Q++ K G S + +
Sbjct: 421 QVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRK--EKSGKTSSILKDKEPIKG 478
Query: 151 PSSSSSSSSSDSESDDEADV------SEVTPRVVSKGRGGLRKPEAS------------- 191
+S + E + + D EV P+ KPE
Sbjct: 479 KEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKV 538
Query: 192 --HSFENRAPRVTVS---AKEKTLLQKPHVDITDPEKPHQPKK----------------K 230
H + P TVS +EK L Q V I KP KK K
Sbjct: 539 QIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPK 598
Query: 231 GSPAKPSEGRENARPKTTMPRSQVDEEFLKQSLKEKQL---QKTFRLNEIDKESQKPFEV 287
+P SE E+ + KT + + E+ + L+E+++ +++ +L+ + K ++KP V
Sbjct: 599 PTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTK-AEKPARV 657
>gi|150418009 transforming, acidic coiled-coil containing protein 2
isoform a [Homo sapiens]
Length = 2948
Score = 44.3 bits (103), Expect = 2e-04
Identities = 91/394 (23%), Positives = 136/394 (34%), Gaps = 77/394 (19%)
Query: 134 KQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVSKGRGGLRKPEASHS 193
+QG++S A + + P + + SD E E P+ ++ LR S
Sbjct: 257 QQGTESSA-VLEKSPLKPMAPIPQDPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRS 315
Query: 194 FENRAPRVTVSAKEKTLLQKP------HVDITD--PEKPHQPKKKGSPAK---------- 235
AP V+A + Q+P H ++ P P+ GS +
Sbjct: 316 NSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGH 375
Query: 236 PSEGRENARPKTTM--PRSQVDEEFLKQSLKEKQLQKTFRLNEIDK-----ESQKPFEVK 288
P G +P + E L S + L T + +Q P V+
Sbjct: 376 PQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVE 435
Query: 289 GPLPVHTKSGLSAPPKGSPAPAVLAEEARAEG----QLQASPPGAAEGHLEK-----PVP 339
P + S S G P A A+E G + Q S G+ H E P P
Sbjct: 436 EP---GSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAP 492
Query: 340 EPQRKAA----------------PPLPRKETSGTQGIEGHLKGGQAIVEDQIPPSNLETV 383
PQ + PPLP++++ V+ PP L
Sbjct: 493 SPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHE--------------VQPGAPPPPLPKA 538
Query: 384 PVENNHGFHEKTAALKLEAEGE----AMEDAAAPGDDRGGTQEPAPVPAEPFDNTTYKNL 439
P E+ G T K+ + A E + +PGD GG +E AP EP D NL
Sbjct: 539 PSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEE-AP---EPPDGGDPGNL 594
Query: 440 QHHDYSTYTFLDLNLELSKFRMPQPSSGRESPRH 473
Q D ++ + E+ K + +PSS ES H
Sbjct: 595 QGEDSQAFS-SKRDPEVGKDELSKPSSDAESRDH 627
Score = 33.9 bits (76), Expect = 0.33
Identities = 108/458 (23%), Positives = 154/458 (33%), Gaps = 101/458 (22%)
Query: 27 GLASTVSLSAESGKSEKGQPQNSKKQSPPKNVVEPKERGKLLATQTAAELSKNLS----- 81
GL VS G+ +G P SP +ERG+ L T+ + E+ +
Sbjct: 467 GLERQVSDLGSKGEHPEGDPGEVPAPSP-------QERGEHLNTEQSHEVQPGVPPPPLP 519
Query: 82 -------SPSSYPPAVNKGRKVASPSPSGSVL-------FTDEGVPKFLSR--------K 119
P + PP + K ++ P G T V K SR K
Sbjct: 520 KEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGK 579
Query: 120 TLVEFPQKVLSPFRKQGSDSEARQVGRKVTSPSSSSSSSSSDSESDDEADVSEVTPRVVS 179
P P QG DS+A R S SSD+ES D P
Sbjct: 580 EEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQP--PR 637
Query: 180 KGRGGLRKPEASHSFENRAPRVTVSAKEKTLLQKPHVD-ITDPEKPHQPKKKGSPAKPS- 237
KG G S + E A + E+ + P D +P P +GS +P
Sbjct: 638 KGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKC 697
Query: 238 ----EGREN----------ARPKTTMPRSQVDEEFLKQSLKEKQLQKTFRLNEIDKES-- 281
+ RE K+ P + V E K E L+ ++ D E
Sbjct: 698 PDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGESTLE-IRKMGSCDGEGLL 756
Query: 282 QKPFEVKGPLPVHTK----SGLSAPPKGSPAPAVLAEEARAEGQLQASPP---------G 328
P + +GP ++ +G+ PP+G A L A Q Q P G
Sbjct: 757 TSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRG 816
Query: 329 AA--------EGHLEKPVPEPQ--------RKAAPPLPRKETSGTQGIEGHLKGGQAIVE 372
AA E HL+ +P+ +A PP KETS + +
Sbjct: 817 AASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSPS----------HPGFK 866
Query: 373 DQIPPSNLETVPVE----NN---HGFHEKTAALKLEAE 403
DQ S+ VPVE NN HG E+ +L+++
Sbjct: 867 DQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQ 904
>gi|15559211 RE1-silencing transcription factor [Homo sapiens]
Length = 1097
Score = 43.9 bits (102), Expect = 3e-04
Identities = 41/187 (21%), Positives = 76/187 (40%), Gaps = 25/187 (13%)
Query: 215 HVDITDPEKPHQPKKKGSPAKPSEGRENARPKTTMPRSQVDEEFLKQSLKEKQLQKTFRL 274
H + D E + KKK + +E + + + ++ +K+S K+K L+
Sbjct: 531 HGPVNDEESSTKKKKKVESKSKNNSQEVPKGDSKVEENKKQNTCMKKSTKKKTLK----- 585
Query: 275 NEIDKESQKPFEVKGPLPVHTKSGLSAPPKGSPAPAVLAEEARAEGQLQASPP---GAAE 331
N+ K+S KP + + PV S PP+ PAP ++ Q++ PP E
Sbjct: 586 NKSSKKSSKPPQKE---PVEKGSAQMDPPQMGPAPTEAVQKGPV--QVELPPPMEHAQME 640
Query: 332 GHLEKPVPE------------PQRKAAPPLPRKETSGTQGIEGHLKGGQAIVEDQIPPSN 379
G +P P+ Q++ PP+ + G Q + H++ + Q +
Sbjct: 641 GAQIRPAPDEPVQMEVVQEGPAQKELLPPVEPAQMVGAQIVLAHMELPPPMETAQTEVAQ 700
Query: 380 LETVPVE 386
+ P+E
Sbjct: 701 MGPAPME 707
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.125 0.346
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,857,502
Number of Sequences: 37866
Number of extensions: 1262520
Number of successful extensions: 8286
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 85
Number of HSP's successfully gapped in prelim test: 577
Number of HSP's that attempted gapping in prelim test: 6422
Number of HSP's gapped (non-prelim): 1655
length of query: 473
length of database: 18,247,518
effective HSP length: 106
effective length of query: 367
effective length of database: 14,233,722
effective search space: 5223775974
effective search space used: 5223775974
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.