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Search of human proteins with 47778925
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47778925 SMAD, mothers against DPP homolog 5 [Homo sapiens]
(465 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47778931 SMAD, mothers against DPP homolog 5 [Homo sapiens] 982 0.0
gi|47778929 SMAD, mothers against DPP homolog 5 [Homo sapiens] 982 0.0
gi|47778925 SMAD, mothers against DPP homolog 5 [Homo sapiens] 982 0.0
gi|51173727 Sma- and Mad-related protein 1 [Homo sapiens] 875 0.0
gi|5174509 Sma- and Mad-related protein 1 [Homo sapiens] 875 0.0
gi|187828357 SMAD family member 9 isoform a [Homo sapiens] 765 0.0
gi|5174519 SMAD family member 9 isoform b [Homo sapiens] 736 0.0
gi|5174513 mothers against decapentaplegic homolog 3 isoform 1 [... 563 e-160
gi|209693426 Sma- and Mad-related protein 2 isoform 2 [Homo sapi... 560 e-159
gi|51173730 Sma- and Mad-related protein 2 isoform 1 [Homo sapiens] 544 e-155
gi|5174511 Sma- and Mad-related protein 2 isoform 1 [Homo sapiens] 544 e-155
gi|223029442 mothers against decapentaplegic homolog 3 isoform 3... 488 e-138
gi|223029440 mothers against decapentaplegic homolog 3 isoform 2... 413 e-115
gi|223029444 mothers against decapentaplegic homolog 3 isoform 4... 345 5e-95
gi|4885457 mothers against decapentaplegic homolog 4 [Homo sapiens] 267 2e-71
gi|218749837 SMAD family member 6 isoform 2 [Homo sapiens] 96 9e-20
gi|92859871 SMAD family member 6 isoform 1 [Homo sapiens] 95 1e-19
gi|5174517 SMAD family member 7 [Homo sapiens] 92 1e-18
gi|193083157 nuclear assembly factor 1 homolog isoform a [Homo s... 46 8e-05
gi|157168329 formin 1 [Homo sapiens] 43 5e-04
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor... 42 0.002
gi|4557317 annexin A11 [Homo sapiens] 42 0.002
gi|22165433 annexin A11 [Homo sapiens] 42 0.002
gi|22165431 annexin A11 [Homo sapiens] 42 0.002
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 41 0.003
gi|126090663 zinc finger homeodomain 4 [Homo sapiens] 41 0.003
gi|47132519 Ras association and pleckstrin homology domains 1 is... 41 0.003
gi|150170670 piccolo isoform 2 [Homo sapiens] 41 0.003
gi|150378539 piccolo isoform 1 [Homo sapiens] 41 0.003
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo... 40 0.003
>gi|47778931 SMAD, mothers against DPP homolog 5 [Homo sapiens]
Length = 465
Score = 982 bits (2538), Expect = 0.0
Identities = 465/465 (100%), Positives = 465/465 (100%)
Query: 1 MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG 60
MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG
Sbjct: 1 MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG 60
Query: 61 QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKE 120
QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKE
Sbjct: 61 QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKE 120
Query: 121 VCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQP 180
VCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQP
Sbjct: 121 VCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQP 180
Query: 181 NNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQP 240
NNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQP
Sbjct: 181 NNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQP 240
Query: 241 MDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300
MDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
Sbjct: 241 MDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300
Query: 301 DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360
DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
Sbjct: 301 DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360
Query: 361 NFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGW 420
NFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGW
Sbjct: 361 NFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGW 420
Query: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS 465
GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS
Sbjct: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS 465
>gi|47778929 SMAD, mothers against DPP homolog 5 [Homo sapiens]
Length = 465
Score = 982 bits (2538), Expect = 0.0
Identities = 465/465 (100%), Positives = 465/465 (100%)
Query: 1 MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG 60
MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG
Sbjct: 1 MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG 60
Query: 61 QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKE 120
QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKE
Sbjct: 61 QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKE 120
Query: 121 VCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQP 180
VCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQP
Sbjct: 121 VCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQP 180
Query: 181 NNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQP 240
NNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQP
Sbjct: 181 NNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQP 240
Query: 241 MDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300
MDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
Sbjct: 241 MDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300
Query: 301 DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360
DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
Sbjct: 301 DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360
Query: 361 NFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGW 420
NFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGW
Sbjct: 361 NFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGW 420
Query: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS 465
GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS
Sbjct: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS 465
>gi|47778925 SMAD, mothers against DPP homolog 5 [Homo sapiens]
Length = 465
Score = 982 bits (2538), Expect = 0.0
Identities = 465/465 (100%), Positives = 465/465 (100%)
Query: 1 MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG 60
MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG
Sbjct: 1 MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG 60
Query: 61 QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKE 120
QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKE
Sbjct: 61 QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKE 120
Query: 121 VCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQP 180
VCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQP
Sbjct: 121 VCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQP 180
Query: 181 NNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQP 240
NNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQP
Sbjct: 181 NNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQP 240
Query: 241 MDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300
MDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
Sbjct: 241 MDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300
Query: 301 DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360
DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
Sbjct: 301 DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360
Query: 361 NFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGW 420
NFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGW
Sbjct: 361 NFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGW 420
Query: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS 465
GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS
Sbjct: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS 465
>gi|51173727 Sma- and Mad-related protein 1 [Homo sapiens]
Length = 465
Score = 875 bits (2262), Expect = 0.0
Identities = 417/465 (89%), Positives = 432/465 (92%), Gaps = 3/465 (0%)
Query: 3 SMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQP 62
++ SLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALS PGQP
Sbjct: 2 NVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQP 61
Query: 63 SKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVC 122
S CVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPL+ CEFPFGSKQKEVC
Sbjct: 62 SNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVC 121
Query: 123 INPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNN 182
INPYHYKRVESPVLPPVLVPRH+E+NPQHSLL QFRNL NEPHMP NATFPDSF QPN+
Sbjct: 122 INPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNS 181
Query: 183 TPFPLSPNSPYPPSP--ASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQP 240
PFP SPNS YP SP +SSTYP+SP SS PGSPFQ+PADTPPPAY+PP+D M QD SQP
Sbjct: 182 HPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQP 241
Query: 241 MDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300
MDT N M P + I+ DVQ VAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
Sbjct: 242 MDT-NMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300
Query: 301 DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360
DPSNNK+RFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
Sbjct: 301 DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360
Query: 361 NFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGW 420
N+HHGFHPTTVCKIPS CSLKIFNNQEFAQLLAQSVNHGFE VYELTKMCTIRMSFVKGW
Sbjct: 361 NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW 420
Query: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS 465
GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSP NPISSVS
Sbjct: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465
>gi|5174509 Sma- and Mad-related protein 1 [Homo sapiens]
Length = 465
Score = 875 bits (2262), Expect = 0.0
Identities = 417/465 (89%), Positives = 432/465 (92%), Gaps = 3/465 (0%)
Query: 3 SMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQP 62
++ SLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALS PGQP
Sbjct: 2 NVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQP 61
Query: 63 SKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVC 122
S CVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPL+ CEFPFGSKQKEVC
Sbjct: 62 SNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVC 121
Query: 123 INPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNN 182
INPYHYKRVESPVLPPVLVPRH+E+NPQHSLL QFRNL NEPHMP NATFPDSF QPN+
Sbjct: 122 INPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNS 181
Query: 183 TPFPLSPNSPYPPSP--ASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQP 240
PFP SPNS YP SP +SSTYP+SP SS PGSPFQ+PADTPPPAY+PP+D M QD SQP
Sbjct: 182 HPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQP 241
Query: 241 MDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300
MDT N M P + I+ DVQ VAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
Sbjct: 242 MDT-NMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300
Query: 301 DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360
DPSNNK+RFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
Sbjct: 301 DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360
Query: 361 NFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGW 420
N+HHGFHPTTVCKIPS CSLKIFNNQEFAQLLAQSVNHGFE VYELTKMCTIRMSFVKGW
Sbjct: 361 NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW 420
Query: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS 465
GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSP NPISSVS
Sbjct: 421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465
>gi|187828357 SMAD family member 9 isoform a [Homo sapiens]
Length = 467
Score = 765 bits (1976), Expect = 0.0
Identities = 367/466 (78%), Positives = 407/466 (87%), Gaps = 5/466 (1%)
Query: 2 TSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQ 61
T ++SLFSFTSPAVKRLLGWKQGDEEEKWAEKAVD+LVKKLKKKKGAM+ELE+ALS PGQ
Sbjct: 5 TPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPGQ 64
Query: 62 PSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEV 121
PSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPL+ CEFPFGSKQKEV
Sbjct: 65 PSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV 124
Query: 122 CINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLS-HNEPHMPQNATFPDSFHQP 180
CINPYHY+RVE+PVLPPVLVPRH+E+NPQ SLL +FR+ S H+EP MP NAT+PDSF QP
Sbjct: 125 CINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQP 184
Query: 181 NNTPFPLSPNSPYPPSPASSTYPNSPAS-SGPGSPFQLPADTPPPAYMPPDDQMGQDNSQ 239
+ P SP+ + SP +++YP+SP S S P SP+Q DTPP Y + Q + Q
Sbjct: 185 PCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQ-SGQ 243
Query: 240 PMDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGF 299
P+D + + ++ SI + D +PV YEEP+HWCS+ YYELNNRVGE F ASS SVL+DGF
Sbjct: 244 PVDATADR--HVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDGF 301
Query: 300 TDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRN 359
TDPSNN++RFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAEC+SDSSIFVQSRN
Sbjct: 302 TDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRN 361
Query: 360 CNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKG 419
CN+ HGFHP TVCKIPS CSLK+FNNQ FAQLLAQSV+HGFE VYELTKMCTIRMSFVKG
Sbjct: 362 CNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKG 421
Query: 420 WGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS 465
WGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSP NPISSVS
Sbjct: 422 WGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 467
>gi|5174519 SMAD family member 9 isoform b [Homo sapiens]
Length = 430
Score = 736 bits (1901), Expect = 0.0
Identities = 356/466 (76%), Positives = 388/466 (83%), Gaps = 42/466 (9%)
Query: 2 TSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQ 61
T ++SLFSFTSPAVKRLLGWKQGDEEEKWAEKAVD+LVKKLKKKKGAM+ELE+ALS PGQ
Sbjct: 5 TPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPGQ 64
Query: 62 PSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEV 121
PSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPL+ CEFPFGSKQKEV
Sbjct: 65 PSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV 124
Query: 122 CINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLS-HNEPHMPQNATFPDSFHQP 180
CINPYHY+RVE+PVLPPVLVPRH+E+NPQ SLL +FR+ S H+EP MP NAT+PDSF QP
Sbjct: 125 CINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQP 184
Query: 181 NNTPFPLSPNSPYPPSPASSTYPNSPAS-SGPGSPFQLPADTPPPAYMPPDDQMGQDNSQ 239
+ P SP+ + SP +++YP+SP S S P SP+Q
Sbjct: 185 PCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQ----------------------- 221
Query: 240 PMDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGF 299
D +PV YEEP+HWCS+ YYELNNRVGE F ASS SVL+DGF
Sbjct: 222 -----------------HSDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDGF 264
Query: 300 TDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRN 359
TDPSNN++RFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAEC+SDSSIFVQSRN
Sbjct: 265 TDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRN 324
Query: 360 CNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKG 419
CN+ HGFHP TVCKIPS CSLK+FNNQ FAQLLAQSV+HGFE VYELTKMCTIRMSFVKG
Sbjct: 325 CNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKG 384
Query: 420 WGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS 465
WGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSP NPISSVS
Sbjct: 385 WGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 430
>gi|5174513 mothers against decapentaplegic homolog 3 isoform 1
[Homo sapiens]
Length = 425
Score = 563 bits (1451), Expect = e-160
Identities = 284/468 (60%), Positives = 336/468 (71%), Gaps = 49/468 (10%)
Query: 4 MASLFSFTSPAVKRLLGWKQGDE---EEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG 60
M+S+ FT P VKRLLGWK+G++ EEKW EKAV +LVKKLKK G ++ELEKA+++
Sbjct: 1 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKT-GQLDELEKAITTQN 59
Query: 61 QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKE 120
+KC+TIPRSLDGRLQVSHRKGLPHVIYCR+WRWPDL SHHEL+ +++CEF F K+ E
Sbjct: 60 VNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDE 119
Query: 121 VCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQP 180
VC+NPYHY+RVE+PVLPPVLVPRH E + +F L +P+N FP
Sbjct: 120 VCVNPYHYQRVETPVLPPVLVPRHTE------IPAEFPPLDDYSHSIPENTNFPAGIEPQ 173
Query: 181 NNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDN-SQ 239
+N P +TPPP Y+ D + +
Sbjct: 174 SNIP-----------------------------------ETPPPGYLSEDGETSDHQMNH 198
Query: 240 PMDT-SNNMIPQIM-PSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVD 297
MD S N+ P M P+ ++ D+QPV Y EP WCSI YYELN RVGE FHAS S+ VD
Sbjct: 199 SMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVD 258
Query: 298 GFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQS 357
GFTDPSN++ RFCLGLLSNVNRN+ +E TRRHIG+GV LYY+GGEV+AECLSDS+IFVQS
Sbjct: 259 GFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQS 317
Query: 358 RNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFV 417
NCN +G+HP TVCKIP C+LKIFNNQEFA LLAQSVN GFEAVY+LT+MCTIRMSFV
Sbjct: 318 PNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFV 377
Query: 418 KGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS 465
KGWGAEY RQ VTSTPCWIE+HL+GPLQWLDKVLTQMGSP SSVS
Sbjct: 378 KGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 425
>gi|209693426 Sma- and Mad-related protein 2 isoform 2 [Homo
sapiens]
Length = 437
Score = 560 bits (1442), Expect = e-159
Identities = 287/479 (59%), Positives = 337/479 (70%), Gaps = 59/479 (12%)
Query: 4 MASLFSFTSPAVKRLLGWK-------------QGDEEEKWAEKAVDALVKKLKKKKGAME 50
M+S+ FT P VKRLLGWK Q +EEKW EKAV +LVKKLKK G ++
Sbjct: 1 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKT-GRLD 59
Query: 51 ELEKALSSPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDIC 110
ELEKA+++ +KCVTIPRSLDGRLQVSHRKGLPHVIYCR+WRWPDL SHHELK ++ C
Sbjct: 60 ELEKAITTQNCNTKCVTIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENC 119
Query: 111 EFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQN 170
E+ F K+ EVC+NPYHY+RVE+PVLPPVLVPRH E +L + L +P+N
Sbjct: 120 EYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTE------ILTELPPLDDYTHSIPEN 173
Query: 171 ATFPDSFHQPNNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPD 230
FP + P S Y P +TPPP Y+ D
Sbjct: 174 TNFPAG----------IEPQSNYIP------------------------ETPPPGYISED 199
Query: 231 DQMG-QDNSQPMDTSN--NMIPQIMPSIS-SRDVQPVAYEEPKHWCSIVYYELNNRVGEA 286
+ Q +Q MDT + + P + ++ S D+QPV Y EP WCSI YYELN RVGE
Sbjct: 200 GETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGET 259
Query: 287 FHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAE 346
FHAS S+ VDGFTDPSN++ RFCLGLLSNVNRN+T+E TRRHIG+GV LYY+GGEV+AE
Sbjct: 260 FHASQPSLTVDGFTDPSNSE-RFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAE 318
Query: 347 CLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYEL 406
CLSDS+IFVQS NCN +G+HP TVCKIP C+LKIFNNQEFA LLAQSVN GFEAVY+L
Sbjct: 319 CLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQL 378
Query: 407 TKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS 465
T+MCTIRMSFVKGWGAEY RQ VTSTPCWIE+HL+GPLQWLDKVLTQMGSP SS+S
Sbjct: 379 TRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 437
>gi|51173730 Sma- and Mad-related protein 2 isoform 1 [Homo sapiens]
Length = 467
Score = 544 bits (1401), Expect = e-155
Identities = 287/509 (56%), Positives = 337/509 (66%), Gaps = 89/509 (17%)
Query: 4 MASLFSFTSPAVKRLLGWK-------------QGDEEEKWAEKAVDALVKKLKKKKGAME 50
M+S+ FT P VKRLLGWK Q +EEKW EKAV +LVKKLKK G ++
Sbjct: 1 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKT-GRLD 59
Query: 51 ELEKALSSPGQPSKCVTIP------------------------------RSLDGRLQVSH 80
ELEKA+++ +KCVTIP RSLDGRLQVSH
Sbjct: 60 ELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSH 119
Query: 81 RKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVESPVLPPVL 140
RKGLPHVIYCR+WRWPDL SHHELK ++ CE+ F K+ EVC+NPYHY+RVE+PVLPPVL
Sbjct: 120 RKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVL 179
Query: 141 VPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSPNSPYPPSPASS 200
VPRH E +L + L +P+N FP + P S Y P
Sbjct: 180 VPRHTE------ILTELPPLDDYTHSIPENTNFPAG----------IEPQSNYIP----- 218
Query: 201 TYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMG-QDNSQPMDTSN--NMIPQIMPSIS- 256
+TPPP Y+ D + Q +Q MDT + + P + ++
Sbjct: 219 -------------------ETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNH 259
Query: 257 SRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSN 316
S D+QPV Y EP WCSI YYELN RVGE FHAS S+ VDGFTDPSN++ RFCLGLLSN
Sbjct: 260 SLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSE-RFCLGLLSN 318
Query: 317 VNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPS 376
VNRN+T+E TRRHIG+GV LYY+GGEV+AECLSDS+IFVQS NCN +G+HP TVCKIP
Sbjct: 319 VNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPP 378
Query: 377 SCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWI 436
C+LKIFNNQEFA LLAQSVN GFEAVY+LT+MCTIRMSFVKGWGAEY RQ VTSTPCWI
Sbjct: 379 GCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWI 438
Query: 437 EIHLHGPLQWLDKVLTQMGSPLNPISSVS 465
E+HL+GPLQWLDKVLTQMGSP SS+S
Sbjct: 439 ELHLNGPLQWLDKVLTQMGSPSVRCSSMS 467
>gi|5174511 Sma- and Mad-related protein 2 isoform 1 [Homo sapiens]
Length = 467
Score = 544 bits (1401), Expect = e-155
Identities = 287/509 (56%), Positives = 337/509 (66%), Gaps = 89/509 (17%)
Query: 4 MASLFSFTSPAVKRLLGWK-------------QGDEEEKWAEKAVDALVKKLKKKKGAME 50
M+S+ FT P VKRLLGWK Q +EEKW EKAV +LVKKLKK G ++
Sbjct: 1 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKT-GRLD 59
Query: 51 ELEKALSSPGQPSKCVTIP------------------------------RSLDGRLQVSH 80
ELEKA+++ +KCVTIP RSLDGRLQVSH
Sbjct: 60 ELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSH 119
Query: 81 RKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVESPVLPPVL 140
RKGLPHVIYCR+WRWPDL SHHELK ++ CE+ F K+ EVC+NPYHY+RVE+PVLPPVL
Sbjct: 120 RKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVL 179
Query: 141 VPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSPNSPYPPSPASS 200
VPRH E +L + L +P+N FP + P S Y P
Sbjct: 180 VPRHTE------ILTELPPLDDYTHSIPENTNFPAG----------IEPQSNYIP----- 218
Query: 201 TYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMG-QDNSQPMDTSN--NMIPQIMPSIS- 256
+TPPP Y+ D + Q +Q MDT + + P + ++
Sbjct: 219 -------------------ETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNH 259
Query: 257 SRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSN 316
S D+QPV Y EP WCSI YYELN RVGE FHAS S+ VDGFTDPSN++ RFCLGLLSN
Sbjct: 260 SLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSE-RFCLGLLSN 318
Query: 317 VNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPS 376
VNRN+T+E TRRHIG+GV LYY+GGEV+AECLSDS+IFVQS NCN +G+HP TVCKIP
Sbjct: 319 VNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPP 378
Query: 377 SCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWI 436
C+LKIFNNQEFA LLAQSVN GFEAVY+LT+MCTIRMSFVKGWGAEY RQ VTSTPCWI
Sbjct: 379 GCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWI 438
Query: 437 EIHLHGPLQWLDKVLTQMGSPLNPISSVS 465
E+HL+GPLQWLDKVLTQMGSP SS+S
Sbjct: 439 ELHLNGPLQWLDKVLTQMGSPSVRCSSMS 467
>gi|223029442 mothers against decapentaplegic homolog 3 isoform 3
[Homo sapiens]
Length = 381
Score = 488 bits (1255), Expect = e-138
Identities = 244/399 (61%), Positives = 283/399 (70%), Gaps = 45/399 (11%)
Query: 70 RSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYK 129
RSLDGRLQVSHRKGLPHVIYCR+WRWPDL SHHEL+ +++CEF F K+ EVC+NPYHY+
Sbjct: 25 RSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQ 84
Query: 130 RVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSP 189
RVE+PVLPPVLVPRH E + +F L +P+N FP +N P
Sbjct: 85 RVETPVLPPVLVPRHTE------IPAEFPPLDDYSHSIPENTNFPAGIEPQSNIP----- 133
Query: 190 NSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDN-SQPMDT-SNNM 247
+TPPP Y+ D + + MD S N+
Sbjct: 134 ------------------------------ETPPPGYLSEDGETSDHQMNHSMDAGSPNL 163
Query: 248 IPQIM-PSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNK 306
P M P+ ++ D+QPV Y EP WCSI YYELN RVGE FHAS S+ VDGFTDPSN++
Sbjct: 164 SPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSE 223
Query: 307 SRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGF 366
RFCLGLLSNVNRN+ +E TRRHIG+GV LYY+GGEV+AECLSDS+IFVQS NCN +G+
Sbjct: 224 -RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGW 282
Query: 367 HPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHR 426
HP TVCKIP C+LKIFNNQEFA LLAQSVN GFEAVY+LT+MCTIRMSFVKGWGAEY R
Sbjct: 283 HPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRR 342
Query: 427 QDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS 465
Q VTSTPCWIE+HL+GPLQWLDKVLTQMGSP SSVS
Sbjct: 343 QTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 381
>gi|223029440 mothers against decapentaplegic homolog 3 isoform 2
[Homo sapiens]
Length = 320
Score = 413 bits (1061), Expect = e-115
Identities = 211/362 (58%), Positives = 248/362 (68%), Gaps = 45/362 (12%)
Query: 107 LDICEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPH 166
+++CEF F K+ EVC+NPYHY+RVE+PVLPPVLVPRH E + +F L
Sbjct: 1 MELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTE------IPAEFPPLDDYSHS 54
Query: 167 MPQNATFPDSFHQPNNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAY 226
+P+N FP +N P +TPPP Y
Sbjct: 55 IPENTNFPAGIEPQSNIP-----------------------------------ETPPPGY 79
Query: 227 MPPDDQMGQDN-SQPMDT-SNNMIPQIM-PSISSRDVQPVAYEEPKHWCSIVYYELNNRV 283
+ D + + MD S N+ P M P+ ++ D+QPV Y EP WCSI YYELN RV
Sbjct: 80 LSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRV 139
Query: 284 GEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEV 343
GE FHAS S+ VDGFTDPSN++ RFCLGLLSNVNRN+ +E TRRHIG+GV LYY+GGEV
Sbjct: 140 GETFHASQPSMTVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEV 198
Query: 344 YAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAV 403
+AECLSDS+IFVQS NCN +G+HP TVCKIP C+LKIFNNQEFA LLAQSVN GFEAV
Sbjct: 199 FAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAV 258
Query: 404 YELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISS 463
Y+LT+MCTIRMSFVKGWGAEY RQ VTSTPCWIE+HL+GPLQWLDKVLTQMGSP SS
Sbjct: 259 YQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSS 318
Query: 464 VS 465
VS
Sbjct: 319 VS 320
>gi|223029444 mothers against decapentaplegic homolog 3 isoform 4
[Homo sapiens]
Length = 230
Score = 345 bits (885), Expect = 5e-95
Identities = 167/223 (74%), Positives = 188/223 (84%), Gaps = 2/223 (0%)
Query: 244 SNNMIPQIM-PSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDP 302
S N+ P M P+ ++ D+QPV Y EP WCSI YYELN RVGE FHAS S+ VDGFTDP
Sbjct: 9 SPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDP 68
Query: 303 SNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNF 362
SN++ RFCLGLLSNVNRN+ +E TRRHIG+GV LYY+GGEV+AECLSDS+IFVQS NCN
Sbjct: 69 SNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQ 127
Query: 363 HHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGA 422
+G+HP TVCKIP C+LKIFNNQEFA LLAQSVN GFEAVY+LT+MCTIRMSFVKGWGA
Sbjct: 128 RYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGA 187
Query: 423 EYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS 465
EY RQ VTSTPCWIE+HL+GPLQWLDKVLTQMGSP SSVS
Sbjct: 188 EYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 230
>gi|4885457 mothers against decapentaplegic homolog 4 [Homo sapiens]
Length = 552
Score = 267 bits (682), Expect = 2e-71
Identities = 194/536 (36%), Positives = 268/536 (50%), Gaps = 108/536 (20%)
Query: 15 VKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG-QPSKCVTIPRSLD 73
V L+ +QG E E +A++A+++LVKKLK+KK ++ L A+++ G PSKCVTI R+LD
Sbjct: 20 VHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLD 79
Query: 74 GRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVES 133
GRLQV+ RKG PHVIY R+WRWPDL +ELK + C++ F K VC+NPYHY+RV S
Sbjct: 80 GRLQVAGRKGFPHVIYARLWRWPDLHK-NELKHVKYCQYAFDLKCDSVCVNPYHYERVVS 138
Query: 134 PVL-----------PPVLVPRH---NEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQ 179
P + P ++ + ++F Q SL + ++ + H P N +++
Sbjct: 139 PGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGHSIQTIQ-HPPSNRASTETY-- 195
Query: 180 PNNTPFPLSPN-------SPYPPSPASSTYPNSPAS--------------SGPGSPFQLP 218
+TP L+P+ + +P P +ST + PAS SGP Q
Sbjct: 196 --STPALLAPSESNATSTANFPNIPVAST--SQPASILGGSHSEGLLQIASGPQPGQQQN 251
Query: 219 ADTPPPA-----------------YMP--PDDQMGQ-DNSQPMDTSNNMIPQIMPSISSR 258
T PA Y P P Q G + PM P +
Sbjct: 252 GFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPG---HYWPVHNEL 308
Query: 259 DVQPVA--YEEPKHWCSIVYYELNNRVGEAFHASSTS--VLVDGFTDPSNNKSRFCLGLL 314
QP + P++WCSI Y+E++ +VGE F S+ V VDG+ DPS RFCLG L
Sbjct: 309 AFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGG-DRFCLGQL 367
Query: 315 SNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAECLSDSSIFVQSRNCNFHHGFHP-TTVC 372
SNV+R IE R HIGKGV L G G+V+ CLSD ++FVQS + G P V
Sbjct: 368 SNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVH 427
Query: 373 KIPSSCSLKIFNNQEFAQLLAQSVNHGFEA------------------------------ 402
KI S +K+F+ ++ + + Q A
Sbjct: 428 KIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAA 487
Query: 403 ----VYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQM 454
V +L ++C +RMSFVKGWG +Y RQ + TPCWIEIHLH LQ LD+VL M
Sbjct: 488 AGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTM 543
>gi|218749837 SMAD family member 6 isoform 2 [Homo sapiens]
Length = 235
Score = 95.5 bits (236), Expect = 9e-20
Identities = 74/244 (30%), Positives = 111/244 (45%), Gaps = 26/244 (10%)
Query: 212 GSPFQLPADTPPP-AYMPPDDQMGQDNSQPMDTSN-----------NMIPQIMPSISSRD 259
G P + PPP + + P D+ +P+D S+ N + S
Sbjct: 5 GKPIETQKSPPPPYSRLSPRDEY-----KPLDLSDSTLSYTETEATNSLITAPGEFSDAS 59
Query: 260 VQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNR 319
+ P A +P HWCS+ Y+E RVG + +V + F D S FCLG L+ R
Sbjct: 60 MSPDA-TKPSHWCSVAYWEHRTRVGRLYAVYDQAVSI--FYDLPQG-SGFCLGQLNLEQR 115
Query: 320 NSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCS 379
+ ++ TR IG G+ L V+A + IFV S + G V K+P S
Sbjct: 116 SESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGG-RALVVRKVPPGYS 174
Query: 380 LKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIH 439
+K+F+ + A + + Y+ ++R+SF KGWG Y RQ +TS PCW+EI
Sbjct: 175 IKVFDFERSGLQHAPEPDAA-DGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEIL 230
Query: 440 LHGP 443
L+ P
Sbjct: 231 LNNP 234
>gi|92859871 SMAD family member 6 isoform 1 [Homo sapiens]
Length = 496
Score = 95.1 bits (235), Expect = 1e-19
Identities = 76/262 (29%), Positives = 118/262 (45%), Gaps = 24/262 (9%)
Query: 197 PASSTYPNSPASSGPG---SPFQLPADTPPPAYMPPDDQMG-QDNSQPMDTSN------- 245
P + + A+ GP +P+ P + PP ++ +D +P+D S+
Sbjct: 243 PLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPRDEYKPLDLSDSTLSYTE 302
Query: 246 ----NMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTD 301
N + S + P A +P HWCS+ Y+E RVG + +V + F D
Sbjct: 303 TEATNSLITAPGEFSDASMSPDA-TKPSHWCSVAYWEHRTRVGRLYAVYDQAVSI--FYD 359
Query: 302 PSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCN 361
S FCLG L+ R+ ++ TR IG G+ L V+A + IFV S +
Sbjct: 360 LPQG-SGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLD 418
Query: 362 FHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWG 421
G V K+P S+K+F+ + A + + Y+ ++R+SF KGWG
Sbjct: 419 APGG-RALVVRKVPPGYSIKVFDFERSGLQHAPEPDAA-DGPYDPN---SVRISFAKGWG 473
Query: 422 AEYHRQDVTSTPCWIEIHLHGP 443
Y RQ +TS PCW+EI L+ P
Sbjct: 474 PCYSRQFITSCPCWLEILLNNP 495
Score = 68.2 bits (165), Expect = 2e-11
Identities = 49/157 (31%), Positives = 79/157 (50%), Gaps = 8/157 (5%)
Query: 37 ALVKKLKKKKGAMEELEKALSSPGQ-PSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRW 95
+L+K+LK++ +++ L +A+ S G P CV +PR+ L++ + P ++ R++RW
Sbjct: 178 SLLKRLKER--SLDTLLEAVESRGGVPGGCVLVPRA---DLRLGGQPAPPQLLLGRLFRW 232
Query: 96 PDLQSHHELKPLDIC-EFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLL 154
PDLQ ELKPL C F + VC NPYH+ R+ P PP R + + L
Sbjct: 233 PDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPRDEYKPLD 292
Query: 155 VQFRNLSHNEPHMPQN-ATFPDSFHQPNNTPFPLSPN 190
+ LS+ E + T P F + +P P+
Sbjct: 293 LSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPS 329
>gi|5174517 SMAD family member 7 [Homo sapiens]
Length = 426
Score = 91.7 bits (226), Expect = 1e-18
Identities = 108/415 (26%), Positives = 170/415 (40%), Gaps = 104/415 (25%)
Query: 37 ALVKKLKKKKGAMEELEKALSSPGQP-SKCVTIPRSLDGRL-----------QVSHRKGL 84
+++KKLK+++ +E L +A+ S G + C+ +P LD RL Q L
Sbjct: 98 SVLKKLKERQ--LELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPAGAQPAQPPSSYSL 155
Query: 85 PHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRH 144
P ++ C+V+RWPDL+ E+K L CE + VC
Sbjct: 156 P-LLLCKVFRWPDLRHSSEVKRLCCCESYGKINPELVCC--------------------- 193
Query: 145 NEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSPNSPYPPSPASSTYPN 204
NP H L E P + +P F L P + P + SS
Sbjct: 194 ---NPHH-----LSRLCELESPPPPYSRYPMDF---------LKPTADCPDAVPSS---- 232
Query: 205 SPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQPMDTSNNMIPQIMPSISSRDVQPVA 264
A+T Y+ P G +SQ + ++P
Sbjct: 233 --------------AETGGTNYLAPG---GLSDSQLL------------------LEP-- 255
Query: 265 YEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTD-PSNNKSRFCLGLLSNVNRNSTI 323
+ HWC + Y+E RVG + S+ D F D P N FCLG L++ N++ +
Sbjct: 256 -GDRSHWCVVAYWEEKTRVGRLYCVQEPSL--DIFYDLPQGNG--FCLGQLNSDNKSQLV 310
Query: 324 ENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCSLKIF 383
+ R IG G+ L V+ S IF++S + + V K+ S+K F
Sbjct: 311 QKVRSKIGCGIQLTREVDGVWVYNRSSYPIFIKSATLD-NPDSRTLLVHKVFPGFSIKAF 369
Query: 384 NNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEI 438
+ ++ A L + +H F + + T+++SFVKGWG Y RQ ++S PCW+E+
Sbjct: 370 DYEK-AYSLQRPNDHEF--MQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEV 421
>gi|193083157 nuclear assembly factor 1 homolog isoform a [Homo
sapiens]
Length = 494
Score = 45.8 bits (107), Expect = 8e-05
Identities = 34/102 (33%), Positives = 45/102 (44%), Gaps = 9/102 (8%)
Query: 142 PRHNEFNPQHSLLVQ---FRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSPNSPYPPSPA 198
P + +N +H + + F + N P MPQ FP +N FPL P P PP P
Sbjct: 391 PPQHFYNSEHMVSQETSGFPSQRQNNPIMPQYP-FPLPVFDMHN--FPLRPPPPPPPPPV 447
Query: 199 SSTY--PNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNS 238
+ + PN A P+ LP PPP +PP G NS
Sbjct: 448 NMGWATPNMAAHPLLNLPYSLPPPPPPPP-LPPPPSSGDSNS 488
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 43.1 bits (100), Expect = 5e-04
Identities = 31/93 (33%), Positives = 36/93 (38%), Gaps = 9/93 (9%)
Query: 137 PPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSPNSPYPPS 196
PP +P P L +LS P P +A P P P P ++ PP
Sbjct: 648 PPASIP------PPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPPPPPPLPPPSSAGPPPP 701
Query: 197 PASSTYPNSPASSGPGSPFQLPADTPPPAYMPP 229
P PNSPA PG P P PPP PP
Sbjct: 702 PPPPPLPNSPAPPNPGGP---PPAPPPPGLAPP 731
Score = 35.8 bits (81), Expect = 0.085
Identities = 33/119 (27%), Positives = 43/119 (36%), Gaps = 8/119 (6%)
Query: 113 PFGSKQKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNAT 172
P S+ K N K++ L + P N+ H+ L ++ N+ Q A
Sbjct: 592 PCESESKTTRSNQLVPKKLNISSLSQLSPP--NDHKDIHAALQPMEGMASNQ----QKAL 645
Query: 173 FPDSFHQPNNTPFP--LSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPP 229
P P P P L SP PP P S P P P P P+ PP PP
Sbjct: 646 PPPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPPPPPPLPPPSSAGPPPPPPP 704
Score = 32.7 bits (73), Expect = 0.72
Identities = 32/109 (29%), Positives = 41/109 (37%), Gaps = 14/109 (12%)
Query: 165 PHMPQNATFPDSFHQPNNTPFPLSPNSPYPPSPASSTYPNSPASSG------PGSPFQLP 218
P P P S P P P PNSP PP+P P +P G PG F L
Sbjct: 684 PPPPPPLPPPSSAGPPPPPPPPPLPNSPAPPNPGGP--PPAPPPPGLAPPPPPGLFFGLG 741
Query: 219 ADTP----PPAYMP--PDDQMGQDNSQPMDTSNNMIPQIMPSISSRDVQ 261
+ + PA P P + Q D S N P + S+ D++
Sbjct: 742 SSSSQCPRKPAIEPSCPMKPLYWTRIQISDRSQNATPTLWDSLEEPDIR 790
>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
preproprotein [Homo sapiens]
Length = 863
Score = 41.6 bits (96), Expect = 0.002
Identities = 33/111 (29%), Positives = 41/111 (36%), Gaps = 15/111 (13%)
Query: 165 PHMPQNATFPDSFHQPNNTPFPLSPNSPYPPSPAS-------STYPNSPASSGPGSPF-- 215
P PQ A Q + FP P+ P PP P S + PN P P P
Sbjct: 746 PGPPQRALLARGTKQASALSFPAPPSRPLPPDPVSKRLQAELADRPNPPTRPLPADPVVR 805
Query: 216 ----QLPADTPPPAYMPPDDQMGQDNSQPMDTSNNMIPQIMPSISSRDVQP 262
Q PA PPP P D G+ S + IP ++ + SR P
Sbjct: 806 SPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAGIPPLV--VPSRPAPP 854
>gi|4557317 annexin A11 [Homo sapiens]
Length = 505
Score = 41.6 bits (96), Expect = 0.002
Identities = 26/69 (37%), Positives = 31/69 (44%), Gaps = 7/69 (10%)
Query: 174 PDSFHQPNNTPFPLSPNSPYPP---SPASS--TYPNSPASSGPGSPFQLPADTPPPAY-- 226
P F QP + P+ P YPP +P S +YP P + PG P P PP AY
Sbjct: 87 PGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPSYPPYPGAPVPGQPMPPPGQQPPGAYPG 146
Query: 227 MPPDDQMGQ 235
PP GQ
Sbjct: 147 QPPVTYPGQ 155
>gi|22165433 annexin A11 [Homo sapiens]
Length = 505
Score = 41.6 bits (96), Expect = 0.002
Identities = 26/69 (37%), Positives = 31/69 (44%), Gaps = 7/69 (10%)
Query: 174 PDSFHQPNNTPFPLSPNSPYPP---SPASS--TYPNSPASSGPGSPFQLPADTPPPAY-- 226
P F QP + P+ P YPP +P S +YP P + PG P P PP AY
Sbjct: 87 PGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPSYPPYPGAPVPGQPMPPPGQQPPGAYPG 146
Query: 227 MPPDDQMGQ 235
PP GQ
Sbjct: 147 QPPVTYPGQ 155
>gi|22165431 annexin A11 [Homo sapiens]
Length = 505
Score = 41.6 bits (96), Expect = 0.002
Identities = 26/69 (37%), Positives = 31/69 (44%), Gaps = 7/69 (10%)
Query: 174 PDSFHQPNNTPFPLSPNSPYPP---SPASS--TYPNSPASSGPGSPFQLPADTPPPAY-- 226
P F QP + P+ P YPP +P S +YP P + PG P P PP AY
Sbjct: 87 PGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPSYPPYPGAPVPGQPMPPPGQQPPGAYPG 146
Query: 227 MPPDDQMGQ 235
PP GQ
Sbjct: 147 QPPVTYPGQ 155
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 1124
Score = 40.8 bits (94), Expect = 0.003
Identities = 27/65 (41%), Positives = 33/65 (50%), Gaps = 6/65 (9%)
Query: 168 PQNATFPDSFHQPNNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYM 227
P AT P S P TP PL+P SP P P+ T P+ PA+ +P P+ T PP
Sbjct: 326 PLPATLPPS--PPLATPLPLAPPSPSAP-PSLQTLPSPPATPPSQAP---PSMTTPPMQA 379
Query: 228 PPDDQ 232
PP Q
Sbjct: 380 PPSLQ 384
Score = 37.0 bits (84), Expect = 0.038
Identities = 36/137 (26%), Positives = 51/137 (37%), Gaps = 16/137 (11%)
Query: 133 SPVLPPVLVPRHNEFNPQ--HSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSPN 190
SP L P+ P +PQ ++L V + P P F P + P S
Sbjct: 639 SPPLSPLATP-----SPQAPNALAVHLLQAPFSPPPSPPVQA---PFSPPASPPVSPSAT 690
Query: 191 SPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPP------DDQMGQDNSQPMDTS 244
P P+ + P S P SP P+ TPPP PP S PM S
Sbjct: 691 PPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPS 750
Query: 245 NNMIPQIMPSISSRDVQ 261
P++ P +++ +Q
Sbjct: 751 ATPPPRVPPLLAAPPLQ 767
Score = 34.7 bits (78), Expect = 0.19
Identities = 37/141 (26%), Positives = 56/141 (39%), Gaps = 13/141 (9%)
Query: 131 VESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNTPF--PLS 188
+++P PP P F+P S V + S P + P + P P+S
Sbjct: 661 LQAPFSPPPSPPVQAPFSPPASPPV---SPSATPPSQAPPSLAAPPLQVPPSPPASPPMS 717
Query: 189 PNS---PYPPSPASST---YPNSPASSGPGSPFQLPADTPPPAYMPPDDQM--GQDNSQP 240
P++ P P P ++ P SP +S P SP P PP P Q+ S P
Sbjct: 718 PSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLP 777
Query: 241 MDTSNNMIPQIMPSISSRDVQ 261
M PQ P++++ +Q
Sbjct: 778 MSPLAKPPPQAPPALATPPLQ 798
Score = 32.3 bits (72), Expect = 0.94
Identities = 33/136 (24%), Positives = 48/136 (35%), Gaps = 13/136 (9%)
Query: 131 VESPVLPPV-----LVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNTPF 185
+ S ++PP+ L P + P NL P Q A+ P + P
Sbjct: 504 LSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPC 563
Query: 186 PLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQPMDTSN 245
P PPSP ++ P +P+S P PA PP P S P+
Sbjct: 564 PAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLP--------SPPLSPLA 615
Query: 246 NMIPQIMPSISSRDVQ 261
PQ P ++ +Q
Sbjct: 616 TPPPQAPPXLALPPLQ 631
Score = 31.2 bits (69), Expect = 2.1
Identities = 35/131 (26%), Positives = 45/131 (34%), Gaps = 12/131 (9%)
Query: 133 SPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSPNSP 192
SP + P P P + +Q P M +AT P P P +P
Sbjct: 713 SPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPP-----PRVPPLLAAPPLQ 767
Query: 193 YPPSPASSTYPNSPASSGPGSPFQLPADTP------PPAYMPPDDQMGQDNSQPMDTSNN 246
PPSP +S P SP + P A P PPA P S PM
Sbjct: 768 VPPSPPAS-LPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLAT 826
Query: 247 MIPQIMPSISS 257
PQ P +++
Sbjct: 827 PPPQAPPVLAA 837
Score = 30.0 bits (66), Expect = 4.7
Identities = 25/96 (26%), Positives = 33/96 (34%), Gaps = 12/96 (12%)
Query: 134 PVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSPNSPY 193
P +PP+L + P + L+ P P P PL P
Sbjct: 755 PRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATP-----------PLQA-LPS 802
Query: 194 PPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPP 229
PP+ P SP++S P SP P PP P
Sbjct: 803 PPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAP 838
>gi|126090663 zinc finger homeodomain 4 [Homo sapiens]
Length = 3571
Score = 40.8 bits (94), Expect = 0.003
Identities = 23/69 (33%), Positives = 31/69 (44%), Gaps = 12/69 (17%)
Query: 173 FPDSFHQPNNTPFPLSPNSPY-----PPSPASSTYPNSPASSGP-------GSPFQLPAD 220
F + + + +P+SP+SP PP P P P+S GP +P Q P
Sbjct: 1936 FARQYREAYDKLYPISPSSPETPPPPPPPPPLPPAPPQPSSMGPVKIPNTVSTPLQAPPP 1995
Query: 221 TPPPAYMPP 229
TPPP PP
Sbjct: 1996 TPPPPPPPP 2004
Score = 32.3 bits (72), Expect = 0.94
Identities = 25/70 (35%), Positives = 32/70 (45%), Gaps = 10/70 (14%)
Query: 180 PNNTP-FPLSPNSPYPPSPASSTYP----NSPA---SSGPGSPF-QLPADTPPPAYMPPD 230
P++ P FP + N+ PP +P +SPA SS P P Q P PPP PP
Sbjct: 3070 PSSLPGFPQNSNTLTPPGAGMLGFPTSATSSPALSLSSAPTKPLLQTPPPPPPPPPPPPS 3129
Query: 231 DQM-GQDNSQ 239
+ GQ Q
Sbjct: 3130 SSLSGQQTEQ 3139
Score = 30.0 bits (66), Expect = 4.7
Identities = 18/58 (31%), Positives = 22/58 (37%), Gaps = 2/58 (3%)
Query: 174 PDSFHQPNNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTP--PPAYMPP 229
P++ P P P P P PP P P P S+ P + D P P M P
Sbjct: 1983 PNTVSTPLQAPPPTPPPPPPPPPPPPPPPPPPPPSAPPQVQLPVSLDLPLFPSIMMQP 2040
Score = 30.0 bits (66), Expect = 4.7
Identities = 27/91 (29%), Positives = 32/91 (35%), Gaps = 11/91 (12%)
Query: 180 PNNTPFPLSPNSPYP--------PSPAS-STYPNSPASSGPGSPFQLPADTPPPAYMPPD 230
P P SP YP PSP S T P P +S P Q P P PP
Sbjct: 2350 PKPEPEKTSPKPEYPAEKPKQSDPSPPSQGTKPALPLASTSSDPPQASTAQPQPQPQPP- 2408
Query: 231 DQMGQDNSQPMDTSNNMIPQIMPSISSRDVQ 261
+ Q +P S +P IS +Q
Sbjct: 2409 -KQPQLIGRPPSASQTPVPSSPLQISMTSLQ 2438
>gi|47132519 Ras association and pleckstrin homology domains 1
isoform 1 [Homo sapiens]
Length = 1250
Score = 40.8 bits (94), Expect = 0.003
Identities = 23/67 (34%), Positives = 31/67 (46%), Gaps = 6/67 (8%)
Query: 179 QPNNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNS 238
QP++ P P SP+ P PP +S +P P SP P PPP P D+ G
Sbjct: 905 QPSSIPVP-SPDFPPPPPESSLVFPPPPP-----SPVPAPPPPPPPTASPTPDKSGSPGK 958
Query: 239 QPMDTSN 245
+ TS+
Sbjct: 959 KTSKTSS 965
Score = 37.7 bits (86), Expect = 0.022
Identities = 23/85 (27%), Positives = 36/85 (42%), Gaps = 9/85 (10%)
Query: 188 SPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQPMDTSNNM 247
+P +P PP P + P PAS P SP P PPP + P+ ++
Sbjct: 802 APPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSV 861
Query: 248 IPQIM---------PSISSRDVQPV 263
+ QI P++ S+ ++PV
Sbjct: 862 VKQIASQFPPPPTPPAMESQPLKPV 886
Score = 32.7 bits (73), Expect = 0.72
Identities = 27/101 (26%), Positives = 38/101 (37%), Gaps = 12/101 (11%)
Query: 134 PVLPPVLVPRHNEFNP---QHSLLVQFRNLSHNE--------PHMPQNATFPDSFHQPNN 182
P LP P P ++S + + +N S + P + Q+ + P N
Sbjct: 647 PPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPN 706
Query: 183 TPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPP 223
P P P PP+P S+ PA P P Q A PP
Sbjct: 707 GVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLP-QFSAPPPP 746
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 40.8 bits (94), Expect = 0.003
Identities = 28/103 (27%), Positives = 40/103 (38%), Gaps = 12/103 (11%)
Query: 184 PFPLSPNSPYPPSPASSTYPNSPASSGPGSPF-QLPADTPPPAYMP-----------PDD 231
P P P S PPS + P GP P Q P T PP+ P P
Sbjct: 489 PPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAK 548
Query: 232 QMGQDNSQPMDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSI 274
Q +++P+ + + P P++S QP + PK C +
Sbjct: 549 PSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPL 591
Score = 33.5 bits (75), Expect = 0.42
Identities = 33/111 (29%), Positives = 41/111 (36%), Gaps = 13/111 (11%)
Query: 133 SPVLPPVLVPRHNEFNPQHSLL-VQFRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSPNS 191
+P PP P H + P + Q L+ +P Q T P T P P
Sbjct: 310 TPGKPPAQQPGHEKSQPGPAKPPAQPSGLT--KPLAQQPGTVKPPVQPPGTTKPPAQPLG 367
Query: 192 PYPPSPASSTYPNSPASSGPGSPF--------QLPADTPPPAYMPPDDQMG 234
P P PA T P+S PG + PA P PA PP Q+G
Sbjct: 368 PAKP-PAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPA-KPPTQQVG 416
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 40.8 bits (94), Expect = 0.003
Identities = 28/103 (27%), Positives = 40/103 (38%), Gaps = 12/103 (11%)
Query: 184 PFPLSPNSPYPPSPASSTYPNSPASSGPGSPF-QLPADTPPPAYMP-----------PDD 231
P P P S PPS + P GP P Q P T PP+ P P
Sbjct: 489 PPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAK 548
Query: 232 QMGQDNSQPMDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSI 274
Q +++P+ + + P P++S QP + PK C +
Sbjct: 549 PSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPL 591
Score = 33.5 bits (75), Expect = 0.42
Identities = 33/111 (29%), Positives = 41/111 (36%), Gaps = 13/111 (11%)
Query: 133 SPVLPPVLVPRHNEFNPQHSLL-VQFRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSPNS 191
+P PP P H + P + Q L+ +P Q T P T P P
Sbjct: 310 TPGKPPAQQPGHEKSQPGPAKPPAQPSGLT--KPLAQQPGTVKPPVQPPGTTKPPAQPLG 367
Query: 192 PYPPSPASSTYPNSPASSGPGSPF--------QLPADTPPPAYMPPDDQMG 234
P P PA T P+S PG + PA P PA PP Q+G
Sbjct: 368 PAKP-PAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPA-KPPTQQVG 416
>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 40.4 bits (93), Expect = 0.003
Identities = 26/85 (30%), Positives = 40/85 (47%), Gaps = 5/85 (5%)
Query: 180 PNNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDD--QMGQDN 237
P+ + P++P+ +P S + P P + P +P+ + PP MP Q+
Sbjct: 738 PSQSQPPVTPSQSHPQVMPSQSQP--PVTPSQSQPRVMPSQSQPPV-MPSQSHPQLTPSQ 794
Query: 238 SQPMDTSNNMIPQIMPSISSRDVQP 262
SQP T + PQ+MPS S V P
Sbjct: 795 SQPPVTPSQRQPQLMPSQSQPPVTP 819
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,105,120
Number of Sequences: 37866
Number of extensions: 1248179
Number of successful extensions: 12045
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 161
Number of HSP's successfully gapped in prelim test: 572
Number of HSP's that attempted gapping in prelim test: 8748
Number of HSP's gapped (non-prelim): 2911
length of query: 465
length of database: 18,247,518
effective HSP length: 106
effective length of query: 359
effective length of database: 14,233,722
effective search space: 5109906198
effective search space used: 5109906198
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.