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Search of human proteins with 47680169
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47680169 3-phosphoinositide dependent protein kinase-1
isoform 2 [Homo sapiens]
(429 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47680169 3-phosphoinositide dependent protein kinase-1 isofor... 883 0.0
gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform... 663 0.0
gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent ... 289 4e-78
gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo ... 289 4e-78
gi|4826948 protein kinase, X-linked [Homo sapiens] 92 1e-18
gi|172073175 microtubule associated serine/threonine kinase-like... 90 4e-18
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 88 1e-17
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 85 1e-16
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 85 1e-16
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 84 2e-16
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 84 2e-16
gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens] 84 2e-16
gi|4885563 protein kinase C, epsilon [Homo sapiens] 83 4e-16
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 83 4e-16
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 81 2e-15
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 81 2e-15
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 81 2e-15
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 81 2e-15
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 81 2e-15
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 81 2e-15
gi|5453974 protein kinase N2 [Homo sapiens] 81 2e-15
gi|4506067 protein kinase C, alpha [Homo sapiens] 80 4e-15
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 79 6e-15
gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens] 79 8e-15
gi|133908623 protein kinase C, iota [Homo sapiens] 79 1e-14
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 79 1e-14
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 79 1e-14
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 78 2e-14
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 78 2e-14
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 78 2e-14
>gi|47680169 3-phosphoinositide dependent protein kinase-1 isoform 2
[Homo sapiens]
Length = 429
Score = 883 bits (2281), Expect = 0.0
Identities = 429/429 (100%), Positives = 429/429 (100%)
Query: 1 MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP 60
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP
Sbjct: 1 MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP 60
Query: 61 GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYATRANSFVGTAQ 120
GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYATRANSFVGTAQ
Sbjct: 61 GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYATRANSFVGTAQ 120
Query: 121 YVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFP 180
YVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFP
Sbjct: 121 YVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFP 180
Query: 181 KARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSE 240
KARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSE
Sbjct: 181 KARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSE 240
Query: 241 DDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELD 300
DDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELD
Sbjct: 241 DDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELD 300
Query: 301 LQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYV 360
LQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYV
Sbjct: 301 LQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYV 360
Query: 361 DPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRY 420
DPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRY
Sbjct: 361 DPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRY 420
Query: 421 QSHPDAAVQ 429
QSHPDAAVQ
Sbjct: 421 QSHPDAAVQ 429
>gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform 1
[Homo sapiens]
Length = 556
Score = 663 bits (1710), Expect = 0.0
Identities = 319/319 (100%), Positives = 319/319 (100%)
Query: 111 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 170
RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL
Sbjct: 238 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 297
Query: 171 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK 230
EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK
Sbjct: 298 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK 357
Query: 231 LTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIH 290
LTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIH
Sbjct: 358 LTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIH 417
Query: 291 DLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLL 350
DLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLL
Sbjct: 418 DLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLL 477
Query: 351 LTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCR 410
LTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCR
Sbjct: 478 LTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCR 537
Query: 411 KIQEVWRQRYQSHPDAAVQ 429
KIQEVWRQRYQSHPDAAVQ
Sbjct: 538 KIQEVWRQRYQSHPDAAVQ 556
Score = 223 bits (567), Expect = 3e-58
Identities = 109/111 (98%), Positives = 110/111 (99%)
Query: 1 MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP 60
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP
Sbjct: 1 MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP 60
Query: 61 GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYATR 111
GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYA +
Sbjct: 61 GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIK 111
>gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent
protein kinase-1 [Homo sapiens]
Length = 471
Score = 289 bits (739), Expect = 4e-78
Identities = 138/138 (100%), Positives = 138/138 (100%)
Query: 111 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 170
RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL
Sbjct: 257 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 316
Query: 171 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK 230
EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK
Sbjct: 317 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK 376
Query: 231 LTAYLPAMSEDDEDCYGN 248
LTAYLPAMSEDDEDCYGN
Sbjct: 377 LTAYLPAMSEDDEDCYGN 394
Score = 208 bits (530), Expect = 7e-54
Identities = 101/103 (98%), Positives = 102/103 (99%)
Query: 9 YDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHA 68
YDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHA
Sbjct: 28 YDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHA 87
Query: 69 QPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYATR 111
QPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYA +
Sbjct: 88 QPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIK 130
>gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo
sapiens]
Length = 396
Score = 289 bits (739), Expect = 4e-78
Identities = 138/138 (100%), Positives = 138/138 (100%)
Query: 111 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 170
RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL
Sbjct: 211 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 270
Query: 171 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK 230
EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK
Sbjct: 271 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK 330
Query: 231 LTAYLPAMSEDDEDCYGN 248
LTAYLPAMSEDDEDCYGN
Sbjct: 331 LTAYLPAMSEDDEDCYGN 348
Score = 169 bits (429), Expect = 3e-42
Identities = 82/84 (97%), Positives = 83/84 (98%)
Query: 28 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 87
MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI
Sbjct: 1 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 60
Query: 88 LGEGSFSTVVLARELATSREYATR 111
LGEGSFSTVVLARELATSREYA +
Sbjct: 61 LGEGSFSTVVLARELATSREYAIK 84
>gi|4826948 protein kinase, X-linked [Homo sapiens]
Length = 358
Score = 91.7 bits (226), Expect = 1e-18
Identities = 45/122 (36%), Positives = 75/122 (61%), Gaps = 1/122 (0%)
Query: 105 SREYATRANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIF 164
+++ R + GT +Y++PE++ K ++ D WALG +I+++++G PPF N + I+
Sbjct: 194 AKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIY 253
Query: 165 QKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLH 224
QKI+ + DFP +DL++KLLV+D T+RLG G +K H +F SV WE +
Sbjct: 254 QKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLG-NMKNGANDVKHHRWFRSVDWEAVP 312
Query: 225 QQ 226
Q+
Sbjct: 313 QR 314
>gi|172073175 microtubule associated serine/threonine kinase-like
[Homo sapiens]
Length = 878
Score = 89.7 bits (221), Expect = 4e-18
Identities = 49/134 (36%), Positives = 72/134 (53%), Gaps = 13/134 (9%)
Query: 116 VGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFP 175
+GT Y++PELL ++ + D WALG +++ + G+PPF +FQ I+K + +P
Sbjct: 738 LGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWP 797
Query: 176 ---EKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLT 232
EK A+ VE LL +D TKR G +E LK HP F V WENL QT P
Sbjct: 798 EGEEKLSDNAQSAVEILLTIDDTKRAGMKE------LKRHPLFSDVDWENLQHQTMP--- 848
Query: 233 AYLPAMSEDDEDCY 246
++P ++ + Y
Sbjct: 849 -FIPQPDDETDTSY 861
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 88.2 bits (217), Expect = 1e-17
Identities = 42/114 (36%), Positives = 66/114 (57%), Gaps = 1/114 (0%)
Query: 110 TRANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIK 169
T ++F GT +Y++PE+L ++ D W+LG ++Y ++ G PPF N KI+K
Sbjct: 248 TVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK 307
Query: 170 LEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL 223
+ + P +ARDL++KLL +A RLG + G ++AHPFF + WE L
Sbjct: 308 CKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDA-GEVQAHPFFRHINWEEL 360
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 85.1 bits (209), Expect = 1e-16
Identities = 42/116 (36%), Positives = 65/116 (56%), Gaps = 1/116 (0%)
Query: 111 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 170
R + GT +Y++PE++ K K+ D WALG +IY++ AG PPF A I++KI+
Sbjct: 195 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254
Query: 171 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 226
+ FP F +DL+ LL +D TKR G G +K H +F + W ++Q+
Sbjct: 255 KVRFPSHFSSDLKDLLRNLLQVDLTKRFG-NLKNGVSDIKTHKWFATTDWIAIYQR 309
Score = 31.6 bits (70), Expect = 1.4
Identities = 15/32 (46%), Positives = 20/32 (62%)
Query: 80 EDFKFGKILGEGSFSTVVLARELATSREYATR 111
EDF+ K LG GSF V+L + AT + YA +
Sbjct: 42 EDFERKKTLGTGSFGRVMLVKHKATEQYYAMK 73
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 85.1 bits (209), Expect = 1e-16
Identities = 42/116 (36%), Positives = 65/116 (56%), Gaps = 1/116 (0%)
Query: 111 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 170
R + GT +Y++PE++ K K+ D WALG +IY++ AG PPF A I++KI+
Sbjct: 242 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 301
Query: 171 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 226
+ FP F +DL+ LL +D TKR G G +K H +F + W ++Q+
Sbjct: 302 KVRFPSHFSSDLKDLLRNLLQVDLTKRFG-NLKNGVSDIKTHKWFATTDWIAIYQR 356
Score = 31.6 bits (70), Expect = 1.4
Identities = 15/32 (46%), Positives = 20/32 (62%)
Query: 80 EDFKFGKILGEGSFSTVVLARELATSREYATR 111
EDF+ K LG GSF V+L + AT + YA +
Sbjct: 89 EDFERKKTLGTGSFGRVMLVKHKATEQYYAMK 120
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 84.3 bits (207), Expect = 2e-16
Identities = 42/116 (36%), Positives = 65/116 (56%), Gaps = 1/116 (0%)
Query: 111 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 170
R + GT +Y++PE++ K K+ D WALG +IY++ AG PPF A I++KI+
Sbjct: 187 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 246
Query: 171 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 226
+ FP F +DL+ LL +D TKR G G +K H +F + W ++Q+
Sbjct: 247 KVRFPSHFSSDLKDLLRNLLQVDLTKRFG-NLKNGVNDIKNHKWFATTDWIAIYQR 301
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 84.3 bits (207), Expect = 2e-16
Identities = 42/116 (36%), Positives = 65/116 (56%), Gaps = 1/116 (0%)
Query: 111 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 170
R + GT +Y++PE++ K K+ D WALG +IY++ AG PPF A I++KI+
Sbjct: 195 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254
Query: 171 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 226
+ FP F +DL+ LL +D TKR G G +K H +F + W ++Q+
Sbjct: 255 KVRFPSHFSSDLKDLLRNLLQVDLTKRFG-NLKNGVNDIKNHKWFATTDWIAIYQR 309
>gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens]
Length = 590
Score = 84.0 bits (206), Expect = 2e-16
Identities = 41/112 (36%), Positives = 68/112 (60%), Gaps = 5/112 (4%)
Query: 116 VGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYL----IFQKIIKLE 171
VGT Y++PE+L + S D W LGC+IY+++ G PFR E + + +++++ E
Sbjct: 346 VGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETE 405
Query: 172 YDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL 223
+ KF +A+ + + LL DA +RLGC+E EG +K HPFF ++ ++ L
Sbjct: 406 EVYSHKFSEEAKSICKMLLTKDAKQRLGCQE-EGAAEVKRHPFFRNMNFKRL 456
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 83.2 bits (204), Expect = 4e-16
Identities = 41/114 (35%), Positives = 65/114 (57%), Gaps = 1/114 (0%)
Query: 114 SFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYD 173
+F GT Y++PE+L E S D WALG ++Y+++AG PPF A NE +F+ I+ +
Sbjct: 566 TFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVL 625
Query: 174 FPEKFFPKARDLVEKLLVLDATKRLGC-EEMEGYGPLKAHPFFESVTWENLHQQ 226
+P +A +++ + + KRLGC G +K HPFF+ + W L Q+
Sbjct: 626 YPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQK 679
Score = 29.6 bits (65), Expect = 5.5
Identities = 14/39 (35%), Positives = 22/39 (56%)
Query: 73 QPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYATR 111
Q ++ ++F F K+LG+GSF V+LA YA +
Sbjct: 399 QAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVK 437
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 83.2 bits (204), Expect = 4e-16
Identities = 46/137 (33%), Positives = 71/137 (51%), Gaps = 6/137 (4%)
Query: 111 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 170
R + GT +Y++PE++ K K+ D WALG +IY++ G PPF A I++KI+
Sbjct: 195 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSG 254
Query: 171 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTP-- 228
FP K + L+ LL +D TKR G G G +K H +F + +W ++++
Sbjct: 255 RVRFPSKLSSDLKHLLRSLLQVDLTKRFG-NLRNGVGDIKNHKWFATTSWIAIYEKKVEA 313
Query: 229 ---PKLTAYLPAMSEDD 242
PK T A + DD
Sbjct: 314 PFIPKYTGPGDASNFDD 330
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 81.3 bits (199), Expect = 2e-15
Identities = 41/125 (32%), Positives = 72/125 (57%), Gaps = 4/125 (3%)
Query: 107 EYATRANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQK 166
E+ + ++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF + N ++
Sbjct: 249 EHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDN 308
Query: 167 IIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 226
I+ AR L+E LL D TKRLG + + + +K+H FF + W++L +
Sbjct: 309 ILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLINWDDLINK 366
Query: 227 --TPP 229
TPP
Sbjct: 367 KITPP 371
Score = 39.7 bits (91), Expect = 0.005
Identities = 23/65 (35%), Positives = 30/65 (46%), Gaps = 1/65 (1%)
Query: 47 QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 106
Q P + P P + P P K P DF F K++G+GSF V+LAR A
Sbjct: 64 QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 122
Query: 107 EYATR 111
YA +
Sbjct: 123 FYAVK 127
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 81.3 bits (199), Expect = 2e-15
Identities = 41/125 (32%), Positives = 72/125 (57%), Gaps = 4/125 (3%)
Query: 107 EYATRANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQK 166
E+ + ++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF + N ++
Sbjct: 263 EHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDN 322
Query: 167 IIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 226
I+ AR L+E LL D TKRLG + + + +K+H FF + W++L +
Sbjct: 323 ILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLINWDDLINK 380
Query: 227 --TPP 229
TPP
Sbjct: 381 KITPP 385
Score = 39.7 bits (91), Expect = 0.005
Identities = 23/65 (35%), Positives = 30/65 (46%), Gaps = 1/65 (1%)
Query: 47 QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 106
Q P + P P + P P K P DF F K++G+GSF V+LAR A
Sbjct: 78 QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 136
Query: 107 EYATR 111
YA +
Sbjct: 137 FYAVK 141
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 81.3 bits (199), Expect = 2e-15
Identities = 41/125 (32%), Positives = 72/125 (57%), Gaps = 4/125 (3%)
Query: 107 EYATRANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQK 166
E+ + ++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF + N ++
Sbjct: 277 EHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDN 336
Query: 167 IIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 226
I+ AR L+E LL D TKRLG + + + +K+H FF + W++L +
Sbjct: 337 ILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLINWDDLINK 394
Query: 227 --TPP 229
TPP
Sbjct: 395 KITPP 399
Score = 39.7 bits (91), Expect = 0.005
Identities = 23/65 (35%), Positives = 30/65 (46%), Gaps = 1/65 (1%)
Query: 47 QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 106
Q P + P P + P P K P DF F K++G+GSF V+LAR A
Sbjct: 92 QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 150
Query: 107 EYATR 111
YA +
Sbjct: 151 FYAVK 155
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 81.3 bits (199), Expect = 2e-15
Identities = 41/125 (32%), Positives = 72/125 (57%), Gaps = 4/125 (3%)
Query: 107 EYATRANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQK 166
E+ + ++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF + N ++
Sbjct: 344 EHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDN 403
Query: 167 IIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 226
I+ AR L+E LL D TKRLG + + + +K+H FF + W++L +
Sbjct: 404 ILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLINWDDLINK 461
Query: 227 --TPP 229
TPP
Sbjct: 462 KITPP 466
Score = 39.7 bits (91), Expect = 0.005
Identities = 23/65 (35%), Positives = 30/65 (46%), Gaps = 1/65 (1%)
Query: 47 QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 106
Q P + P P + P P K P DF F K++G+GSF V+LAR A
Sbjct: 159 QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 217
Query: 107 EYATR 111
YA +
Sbjct: 218 FYAVK 222
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 81.3 bits (199), Expect = 2e-15
Identities = 45/143 (31%), Positives = 80/143 (55%), Gaps = 11/143 (7%)
Query: 97 VLARELATSREYAT----RANSFVGTAQYVSPELLT--EKSACKSSDLWALGCIIYQLVA 150
V+ + S+E+ RA SF GT +Y++P+++ + K+ D W+LG ++Y+L+
Sbjct: 191 VVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLT 250
Query: 151 GLPPFRAGNEYL----IFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGY 206
G PF E I ++I+K E +P++ A+DL+++LL+ D KRLGC +
Sbjct: 251 GASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDA- 309
Query: 207 GPLKAHPFFESVTWENLHQQTPP 229
+K H FF+ + W++L + P
Sbjct: 310 DEIKEHLFFQKINWDDLAAKKVP 332
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 81.3 bits (199), Expect = 2e-15
Identities = 45/143 (31%), Positives = 80/143 (55%), Gaps = 11/143 (7%)
Query: 97 VLARELATSREYAT----RANSFVGTAQYVSPELLT--EKSACKSSDLWALGCIIYQLVA 150
V+ + S+E+ RA SF GT +Y++P+++ + K+ D W+LG ++Y+L+
Sbjct: 191 VVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLT 250
Query: 151 GLPPFRAGNEYL----IFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGY 206
G PF E I ++I+K E +P++ A+DL+++LL+ D KRLGC +
Sbjct: 251 GASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDA- 309
Query: 207 GPLKAHPFFESVTWENLHQQTPP 229
+K H FF+ + W++L + P
Sbjct: 310 DEIKEHLFFQKINWDDLAAKKVP 332
Score = 57.0 bits (136), Expect = 3e-08
Identities = 59/217 (27%), Positives = 96/217 (44%), Gaps = 31/217 (14%)
Query: 118 TAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYL-------IFQKIIKL 170
T Y +PELL + +S DLW+LG I+Y +++G PF++ + L I +KI K
Sbjct: 585 TLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKG 644
Query: 171 EYDFP----EKFFPKARDLVEKLLVLDATKRLGC------EEMEGYGPLKAHPFF--ESV 218
++ F + +A+DL++ LL +D KRL E ++ L ++P + +
Sbjct: 645 DFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDIL 704
Query: 219 TWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNL----------LSQFGCMQVSSSSSSH 268
T K T + + + C N D S + SSS SSH
Sbjct: 705 GSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSH 764
Query: 269 SLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSE 305
S S+ G + + + Q + DSN+ E QFS+
Sbjct: 765 SSSSHSHG--KTTPTKTLQPSNPADSNNPETLFQFSD 799
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 80.9 bits (198), Expect = 2e-15
Identities = 39/116 (33%), Positives = 65/116 (56%), Gaps = 1/116 (0%)
Query: 108 YATRANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKI 167
Y R ++F GT ++++PE+LTE S ++ D W LG +IY+++ G PF +E +F I
Sbjct: 810 YGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSI 869
Query: 168 IKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL 223
+ E +P +A ++ +LL + +RLG E + +K HPFF + W L
Sbjct: 870 VNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDA-EDVKKHPFFRLIDWSAL 924
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 80.1 bits (196), Expect = 4e-15
Identities = 38/113 (33%), Positives = 63/113 (55%), Gaps = 1/113 (0%)
Query: 114 SFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYD 173
+F GT Y++PE++ + KS D WA G ++Y+++AG PPF +E +FQ I++
Sbjct: 497 TFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVS 556
Query: 174 FPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 226
+P+ +A + + L+ KRLGC EG ++ H FF + WE L +
Sbjct: 557 YPKSLSKEAVSICKGLMTKHPAKRLGCGP-EGERDVREHAFFRRIDWEKLENR 608
Score = 30.4 bits (67), Expect = 3.2
Identities = 16/43 (37%), Positives = 22/43 (51%)
Query: 69 QPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYATR 111
QP + + DF F +LG+GSF V+LA T YA +
Sbjct: 326 QPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIK 368
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 79.3 bits (194), Expect = 6e-15
Identities = 38/111 (34%), Positives = 64/111 (57%), Gaps = 1/111 (0%)
Query: 113 NSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEY 172
++F GT +Y++PE+L ++ D W+LG ++Y ++ G PPF A N KII+ +
Sbjct: 227 HTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKL 286
Query: 173 DFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL 223
P P ARDLV+K L + ++R+G + ++ HPFF + W++L
Sbjct: 287 ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDA-ADVQRHPFFRHMNWDDL 336
>gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens]
Length = 688
Score = 79.0 bits (193), Expect = 8e-15
Identities = 52/167 (31%), Positives = 92/167 (55%), Gaps = 11/167 (6%)
Query: 89 GEGSFSTVVLARELATSREYATRANSFVGTAQYVSPELLTEKSACKSSDLW-ALGCIIYQ 147
G S + LA + + + +A+ VGT Y++PE+L + +A SS W +LGC++++
Sbjct: 329 GHARISDLGLACDFSKKKPHAS-----VGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFK 383
Query: 148 LVAGLPPFR---AGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEME 204
L+ G PFR +++ I + + + + P+ F P+ + L+E LL D +KRLGC
Sbjct: 384 LLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHG-G 442
Query: 205 GYGPLKAHPFFESVTWENLH-QQTPPKLTAYLPAMSEDDEDCYGNYD 250
G +K H FF+ V W++++ Q+ PP L ++ D G++D
Sbjct: 443 GSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFD 489
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 78.6 bits (192), Expect = 1e-14
Identities = 40/128 (31%), Positives = 67/128 (52%), Gaps = 11/128 (8%)
Query: 113 NSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA---------GNEYLI 163
++F GT Y++PE+L + S D WALG ++++++AG PF E +
Sbjct: 411 STFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYL 470
Query: 164 FQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL 223
FQ I++ + P KA +++ L D +RLGC G+ ++ HPFF +V W+ +
Sbjct: 471 FQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMM 530
Query: 224 HQQ--TPP 229
Q+ PP
Sbjct: 531 EQKQVVPP 538
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 78.6 bits (192), Expect = 1e-14
Identities = 45/149 (30%), Positives = 78/149 (52%), Gaps = 5/149 (3%)
Query: 108 YATRANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKI 167
Y R ++F GT ++++PE+LT+ S ++ D W LG ++Y+++ G PF +E +F I
Sbjct: 774 YGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSI 833
Query: 168 IKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWEN-LHQQ 226
+ E +P +A ++ +LL + +RLG E + +K PFF ++ WE L ++
Sbjct: 834 VNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDA-EDVKKQPFFRTLGWEALLARR 892
Query: 227 TPPKLTAYLPA---MSEDDEDCYGNYDNL 252
PP L +S DE+ G L
Sbjct: 893 LPPPFVPTLSGRTDVSNFDEEFTGEAPTL 921
Score = 35.0 bits (79), Expect = 0.13
Identities = 29/87 (33%), Positives = 37/87 (42%), Gaps = 11/87 (12%)
Query: 32 QTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPP---QPRKKRP---EDFKFG 85
Q S PP P S P + TA P S P P P +K P EDFKF
Sbjct: 570 QKSSRDPPSSPS-SLSSPIQESTA----PELPSETQETPGPALCSPLRKSPLTLEDFKFL 624
Query: 86 KILGEGSFSTVVLARELATSREYATRA 112
+LG G F V+L+ + +A +A
Sbjct: 625 AVLGRGHFGKVLLSEFRPSGELFAIKA 651
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 78.6 bits (192), Expect = 1e-14
Identities = 45/149 (30%), Positives = 78/149 (52%), Gaps = 5/149 (3%)
Query: 108 YATRANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKI 167
Y R ++F GT ++++PE+LT+ S ++ D W LG ++Y+++ G PF +E +F I
Sbjct: 768 YGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSI 827
Query: 168 IKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWEN-LHQQ 226
+ E +P +A ++ +LL + +RLG E + +K PFF ++ WE L ++
Sbjct: 828 VNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDA-EDVKKQPFFRTLGWEALLARR 886
Query: 227 TPPKLTAYLPA---MSEDDEDCYGNYDNL 252
PP L +S DE+ G L
Sbjct: 887 LPPPFVPTLSGRTDVSNFDEEFTGEAPTL 915
Score = 35.0 bits (79), Expect = 0.13
Identities = 29/87 (33%), Positives = 37/87 (42%), Gaps = 11/87 (12%)
Query: 32 QTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPP---QPRKKRP---EDFKFG 85
Q S PP P S P + TA P S P P P +K P EDFKF
Sbjct: 564 QKSSRDPPSSPS-SLSSPIQESTA----PELPSETQETPGPALCSPLRKSPLTLEDFKFL 618
Query: 86 KILGEGSFSTVVLARELATSREYATRA 112
+LG G F V+L+ + +A +A
Sbjct: 619 AVLGRGHFGKVLLSEFRPSGELFAIKA 645
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 77.8 bits (190), Expect = 2e-14
Identities = 46/154 (29%), Positives = 75/154 (48%), Gaps = 18/154 (11%)
Query: 114 SFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYD 173
+F GT Y++PE++ + KS D WA G ++Y+++AG PF +E +FQ I++
Sbjct: 500 TFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVA 559
Query: 174 FPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQ---QTPPK 230
+P+ +A + + L+ KRLGC EG +K H FF + WE L + Q P K
Sbjct: 560 YPKSMSKEAVAICKGLMTKHPGKRLGCGP-EGERDIKEHAFFRYIDWEKLERKEIQPPYK 618
Query: 231 --------------LTAYLPAMSEDDEDCYGNYD 250
T + P ++ D++ N D
Sbjct: 619 PKACGRNAENFDRFFTRHPPVLTPPDQEVIRNID 652
Score = 29.6 bits (65), Expect = 5.5
Identities = 13/31 (41%), Positives = 18/31 (58%)
Query: 81 DFKFGKILGEGSFSTVVLARELATSREYATR 111
DF F +LG+GSF V+L+ T YA +
Sbjct: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVK 371
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 77.8 bits (190), Expect = 2e-14
Identities = 45/142 (31%), Positives = 78/142 (54%), Gaps = 10/142 (7%)
Query: 97 VLARELATSREYAT----RANSFVGTAQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAG 151
++ + S+E+ T R SF GT +Y++PE++ K+ K+ D W+LG ++++L+ G
Sbjct: 175 IVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTG 234
Query: 152 LPPFRAGNEYL----IFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYG 207
PF E + ++I+K FP + P A+DL+++LL D KRLG +G
Sbjct: 235 ASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGP-QGAQ 293
Query: 208 PLKAHPFFESVTWENLHQQTPP 229
++ HPFF+ + W L + P
Sbjct: 294 EVRNHPFFQGLDWVALAARKIP 315
Score = 51.2 bits (121), Expect = 2e-06
Identities = 31/99 (31%), Positives = 51/99 (51%), Gaps = 11/99 (11%)
Query: 118 TAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEY-----------LIFQK 166
T QY +PELL ++ +S DLW+LG I+Y +++G PF+ + I +
Sbjct: 566 TLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREG 625
Query: 167 IIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEG 205
L+ + + +A++LV LL +D KRL E + G
Sbjct: 626 RFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRG 664
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 77.8 bits (190), Expect = 2e-14
Identities = 45/142 (31%), Positives = 78/142 (54%), Gaps = 10/142 (7%)
Query: 97 VLARELATSREYAT----RANSFVGTAQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAG 151
++ + S+E+ T R SF GT +Y++PE++ K+ K+ D W+LG ++++L+ G
Sbjct: 175 IVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTG 234
Query: 152 LPPFRAGNEYL----IFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYG 207
PF E + ++I+K FP + P A+DL+++LL D KRLG +G
Sbjct: 235 ASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGP-QGAQ 293
Query: 208 PLKAHPFFESVTWENLHQQTPP 229
++ HPFF+ + W L + P
Sbjct: 294 EVRNHPFFQGLDWVALAARKIP 315
Score = 51.2 bits (121), Expect = 2e-06
Identities = 31/99 (31%), Positives = 51/99 (51%), Gaps = 11/99 (11%)
Query: 118 TAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEY-----------LIFQK 166
T QY +PELL ++ +S DLW+LG I+Y +++G PF+ + I +
Sbjct: 572 TLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREG 631
Query: 167 IIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEG 205
L+ + + +A++LV LL +D KRL E + G
Sbjct: 632 RFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRG 670
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,143,543
Number of Sequences: 37866
Number of extensions: 1011880
Number of successful extensions: 6405
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 408
Number of HSP's successfully gapped in prelim test: 266
Number of HSP's that attempted gapping in prelim test: 5179
Number of HSP's gapped (non-prelim): 1283
length of query: 429
length of database: 18,247,518
effective HSP length: 105
effective length of query: 324
effective length of database: 14,271,588
effective search space: 4623994512
effective search space used: 4623994512
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.