Search of human proteins with 46575934

Search of human proteins with 46575934

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46575934 KIAA1680 protein isoform 2 [Homo sapiens]
         (677 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46575934 KIAA1680 protein isoform 2 [Homo sapiens]                1331   0.0  
gi|222831647 KIAA1680 protein isoform 1 [Homo sapiens]               1315   0.0  
gi|80861486 granule cell antiserum positive 14 [Homo sapiens]          80   6e-15
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    48   3e-05
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]     45   2e-04
gi|239758038 PREDICTED: mucin 3A, cell surface associated, parti...    45   2e-04
gi|60097902 filaggrin [Homo sapiens]                                   43   8e-04
gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithor...    42   0.001
gi|40068059 CBF1 interacting corepressor [Homo sapiens]                40   0.007
gi|33356174 pinin, desmosome associated protein [Homo sapiens]         40   0.009
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        40   0.009
gi|239752529 PREDICTED: similar to mucin [Homo sapiens]                39   0.021
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...    39   0.021
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...    39   0.021
gi|50962882 G patch domain containing 8 [Homo sapiens]                 38   0.027
gi|67782356 corneodesmosin precursor [Homo sapiens]                    38   0.035
gi|196114970 protein tyrosine phosphatase, non-receptor type 12 ...    37   0.046
gi|196114967 protein tyrosine phosphatase, non-receptor type 12 ...    37   0.046
gi|196114951 protein tyrosine phosphatase, non-receptor type 12 ...    37   0.046
gi|59710093 G-protein coupled receptor 112 [Homo sapiens]              37   0.046
gi|55741677 SET domain containing 1A [Homo sapiens]                    37   0.060
gi|62988361 absent in melanoma 1 [Homo sapiens]                        37   0.060
gi|21314720 Smad nuclear interacting protein [Homo sapiens]            37   0.060
gi|188497758 ubiquitin associated protein 2-like isoform a [Homo...    37   0.060
gi|188497756 ubiquitin associated protein 2-like isoform b [Homo...    37   0.060
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...    37   0.078
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                     37   0.078
gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sap...    37   0.078
gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sap...    37   0.078
gi|239743291 PREDICTED: mucin 3A, intestinal [Homo sapiens]            36   0.10 

>gi|46575934 KIAA1680 protein isoform 2 [Homo sapiens]
          Length = 677

 Score = 1331 bits (3444), Expect = 0.0
 Identities = 677/677 (100%), Positives = 677/677 (100%)

Query: 1   MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRR 60
           MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRR
Sbjct: 1   MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRR 60

Query: 61  SIFRTPSISFHHKKGSEPKQEPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFS 120
           SIFRTPSISFHHKKGSEPKQEPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFS
Sbjct: 61  SIFRTPSISFHHKKGSEPKQEPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFS 120

Query: 121 SSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL 180
           SSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL
Sbjct: 121 SSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL 180

Query: 181 LPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGS 240
           LPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGS
Sbjct: 181 LPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGS 240

Query: 241 SLQSPLLSADLTTAQTPSEFLALTEDSVSEMDAFSKSGSMASHCDNFGHNDSTSQMSLNS 300
           SLQSPLLSADLTTAQTPSEFLALTEDSVSEMDAFSKSGSMASHCDNFGHNDSTSQMSLNS
Sbjct: 241 SLQSPLLSADLTTAQTPSEFLALTEDSVSEMDAFSKSGSMASHCDNFGHNDSTSQMSLNS 300

Query: 301 AAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSV 360
           AAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSV
Sbjct: 301 AAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSV 360

Query: 361 SHSESNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIP 420
           SHSESNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIP
Sbjct: 361 SHSESNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIP 420

Query: 421 TSGDHHIFNKTSHGYEANPAKVLASSLSPFREGRFIERRLRSSSEGTAGSSRMILKPKDG 480
           TSGDHHIFNKTSHGYEANPAKVLASSLSPFREGRFIERRLRSSSEGTAGSSRMILKPKDG
Sbjct: 421 TSGDHHIFNKTSHGYEANPAKVLASSLSPFREGRFIERRLRSSSEGTAGSSRMILKPKDG 480

Query: 481 NIEEVNSLRKQRAGSSSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDS 540
           NIEEVNSLRKQRAGSSSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDS
Sbjct: 481 NIEEVNSLRKQRAGSSSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDS 540

Query: 541 YHSVVSCAAVVLTPMEPMIEMKKREEPEFPEPSKQNLSLKLTKDVDQEARCSHISRMPNS 600
           YHSVVSCAAVVLTPMEPMIEMKKREEPEFPEPSKQNLSLKLTKDVDQEARCSHISRMPNS
Sbjct: 541 YHSVVSCAAVVLTPMEPMIEMKKREEPEFPEPSKQNLSLKLTKDVDQEARCSHISRMPNS 600

Query: 601 PSADWPLQGVEENGGIDSLPFRLMLQDCTAVKTLLLKMKRVLQESADMSPASSTTSLPVS 660
           PSADWPLQGVEENGGIDSLPFRLMLQDCTAVKTLLLKMKRVLQESADMSPASSTTSLPVS
Sbjct: 601 PSADWPLQGVEENGGIDSLPFRLMLQDCTAVKTLLLKMKRVLQESADMSPASSTTSLPVS 660

Query: 661 PLTEEPVPFKTTYPREF 677
           PLTEEPVPFKTTYPREF
Sbjct: 661 PLTEEPVPFKTTYPREF 677


>gi|222831647 KIAA1680 protein isoform 1 [Homo sapiens]
          Length = 900

 Score = 1315 bits (3404), Expect = 0.0
 Identities = 670/670 (100%), Positives = 670/670 (100%)

Query: 1   MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRR 60
           MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRR
Sbjct: 1   MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRR 60

Query: 61  SIFRTPSISFHHKKGSEPKQEPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFS 120
           SIFRTPSISFHHKKGSEPKQEPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFS
Sbjct: 61  SIFRTPSISFHHKKGSEPKQEPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFS 120

Query: 121 SSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL 180
           SSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL
Sbjct: 121 SSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL 180

Query: 181 LPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGS 240
           LPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGS
Sbjct: 181 LPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGS 240

Query: 241 SLQSPLLSADLTTAQTPSEFLALTEDSVSEMDAFSKSGSMASHCDNFGHNDSTSQMSLNS 300
           SLQSPLLSADLTTAQTPSEFLALTEDSVSEMDAFSKSGSMASHCDNFGHNDSTSQMSLNS
Sbjct: 241 SLQSPLLSADLTTAQTPSEFLALTEDSVSEMDAFSKSGSMASHCDNFGHNDSTSQMSLNS 300

Query: 301 AAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSV 360
           AAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSV
Sbjct: 301 AAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSV 360

Query: 361 SHSESNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIP 420
           SHSESNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIP
Sbjct: 361 SHSESNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIP 420

Query: 421 TSGDHHIFNKTSHGYEANPAKVLASSLSPFREGRFIERRLRSSSEGTAGSSRMILKPKDG 480
           TSGDHHIFNKTSHGYEANPAKVLASSLSPFREGRFIERRLRSSSEGTAGSSRMILKPKDG
Sbjct: 421 TSGDHHIFNKTSHGYEANPAKVLASSLSPFREGRFIERRLRSSSEGTAGSSRMILKPKDG 480

Query: 481 NIEEVNSLRKQRAGSSSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDS 540
           NIEEVNSLRKQRAGSSSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDS
Sbjct: 481 NIEEVNSLRKQRAGSSSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDS 540

Query: 541 YHSVVSCAAVVLTPMEPMIEMKKREEPEFPEPSKQNLSLKLTKDVDQEARCSHISRMPNS 600
           YHSVVSCAAVVLTPMEPMIEMKKREEPEFPEPSKQNLSLKLTKDVDQEARCSHISRMPNS
Sbjct: 541 YHSVVSCAAVVLTPMEPMIEMKKREEPEFPEPSKQNLSLKLTKDVDQEARCSHISRMPNS 600

Query: 601 PSADWPLQGVEENGGIDSLPFRLMLQDCTAVKTLLLKMKRVLQESADMSPASSTTSLPVS 660
           PSADWPLQGVEENGGIDSLPFRLMLQDCTAVKTLLLKMKRVLQESADMSPASSTTSLPVS
Sbjct: 601 PSADWPLQGVEENGGIDSLPFRLMLQDCTAVKTLLLKMKRVLQESADMSPASSTTSLPVS 660

Query: 661 PLTEEPVPFK 670
           PLTEEPVPFK
Sbjct: 661 PLTEEPVPFK 670


>gi|80861486 granule cell antiserum positive 14 [Homo sapiens]
          Length = 834

 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 81/243 (33%), Positives = 107/243 (44%), Gaps = 38/243 (15%)

Query: 443 LASSLSPFREGRFIERRLRSSSEGTAGSSRMILKPKDGNIEEVNSLRKQRAGSSSSKMNS 502
           L S  + +R G   E     SS+GT       L+P  GN+  V S         SS+MNS
Sbjct: 486 LVSPDTDYRAGSSFELSPSDSSDGTYMWDEEGLEPI-GNVHPVGSYE-------SSEMNS 537

Query: 503 LDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDSYHSVVSCAAVVLTPMEPMIEMK 562
           +D+LNNL SC+L++DDLMLD++  E+  L    C  D+ +        V  P E      
Sbjct: 538 IDILNNLESCDLEDDDLMLDVDLPEDAPLENVEC--DNMNRFDRPDRNVRQPQE---GFW 592

Query: 563 KREEPEFPEPSKQNLSLKLTKDVDQEARCSHISRMPNSPSADWPLQGVEENGG------- 615
           KR    +      +LS     D       S +SR   SP  + PL   E  GG       
Sbjct: 593 KRPPQRWSGQEHYHLS---HPDHYHHHGKSDLSR--GSPYRESPLGHFESYGGMPFFQAQ 647

Query: 616 ------------IDSLPFRLMLQDCTAVKTLLLKMKRVL-QESADMSPASSTTSLPVSPL 662
                       +D +  R M+QDCTAVKT LLK+KR+L Q     S      SLP SP 
Sbjct: 648 KMFVDVPENTVILDEMTLRHMVQDCTAVKTQLLKLKRLLHQHDGSGSLHDIQLSLPSSPE 707

Query: 663 TEE 665
            E+
Sbjct: 708 PED 710


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 73/362 (20%), Positives = 138/362 (38%), Gaps = 7/362 (1%)

Query: 27   DSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQN 86
            DS  SS SS N+    SS+ S ++ SS S+    S   + S +      S       + N
Sbjct: 922  DSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSN 981

Query: 87   LS----ISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTE--DFEREKE 140
             S     S+ +    S+    S +    +    S   S S N   + + ++  D     +
Sbjct: 982  SSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSD 1041

Query: 141  HSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKLLPKSFSSHYKFSKPVLQSQS 200
             S + +   +  SS  S+  DS  + D +  S    +      S SS    S     S  
Sbjct: 1042 SSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSD 1101

Query: 201  ISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEF 260
             S    S  S + +   +       +  S S D ++ + SS  S    +  ++  + S  
Sbjct: 1102 SSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSD 1161

Query: 261  LALTEDSVSEMDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAIMS 320
             + + DS    D+   S S  S  D+   +DS+     + ++ +  +++ + +   +  S
Sbjct: 1162 SSDSSDSSDSSDSSDSSNSSDSS-DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1220

Query: 321  PGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSVSHSESNLPADSEREENIGLQ 380
                  +   S ES+   ++S ++        ++   +S S S+SN  +DS+ +   G  
Sbjct: 1221 DSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNN 1280

Query: 381  NG 382
            NG
Sbjct: 1281 NG 1282


>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
          Length = 494

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 69/302 (22%), Positives = 114/302 (37%), Gaps = 36/302 (11%)

Query: 5   GSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFR 64
           GSRR    SR     RS +R   S  S   S ++   HS S S + S S S  K RS  +
Sbjct: 178 GSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQ 237

Query: 65  TPSISFHHKKGSEPKQEPTNQNLSISNGAQPGHSNM-QKLSLEEHIKTRGRHSVGFSSSR 123
           + S S   K  S  K++  +++ S             +K+   +++      S     S+
Sbjct: 238 SRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSK 297

Query: 124 NKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKLLPK 183
           +K  +RS     E EK  S ++                         RS ++S R+   +
Sbjct: 298 SKSRSRSQERRVEEEKRGSVSRG------------------------RSQEKSLRQSRSR 333

Query: 184 SFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQ 243
           S S     S+   +S+S    +  + S E ++ + R       S         +AGSS +
Sbjct: 334 SRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKK 393

Query: 244 SPLLSADLTTAQTPSEFLALTEDSVSEMDAFSKSGSM----ASHCDNFGHNDSTSQMSLN 299
                 D + +++PS        SVS+    +KS S         +N G N  T   S +
Sbjct: 394 KKKEDTDRSQSRSPSR-------SVSKEREHAKSESSQREGRGESENAGTNQETRSRSRS 446

Query: 300 SA 301
           ++
Sbjct: 447 NS 448


>gi|239758038 PREDICTED: mucin 3A, cell surface associated, partial
           [Homo sapiens]
          Length = 909

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 69/300 (23%), Positives = 113/300 (37%), Gaps = 30/300 (10%)

Query: 13  SRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNS-SSGSTGKRRSIFRTPSISFH 71
           S  P F  SI     +  S+PS ++++    ++  ST S +S  T    +   TPS +  
Sbjct: 26  SSTPSFTSSITTTETTSHSTPSFTSSISTTETTSHSTPSFTSLITITETTSHSTPSYTTS 85

Query: 72  HKKGSEPKQEPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSL 131
                 P     +   SI+    P HS     S     +T    +  F+SS     T S 
Sbjct: 86  ITTTETPSHSTPSYTTSITTTETPSHSTPSFTSSITTTETTSHSTPSFTSSIRTTETTS- 144

Query: 132 TEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKLLPKSFSSHYKF 191
                    +ST      N ++   S    S  T   T  +   ST      SFSS    
Sbjct: 145 ---------YSTPSFTSSNTITETTSHSTPSYITSITTTETPSSST-----PSFSSSITT 190

Query: 192 SKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADL 251
           ++    S S      S  + E T +         ++PS +  +T    +S  +P  ++ +
Sbjct: 191 TETT--SHSTPGFTSSITTTETTSH---------STPSFTSSITTTETTSHDTPSFTSSI 239

Query: 252 TTAQTPSEFLALTEDSVSEMDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELT 311
           TT++TPS     +   ++     + S S  S   +    ++TS  S +S   + TTTE T
Sbjct: 240 TTSETPSHSTPSSTSLITTTK--TTSHSTPSFTSSITTTETTSH-SAHSFTSSITTTETT 296



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 82/400 (20%), Positives = 139/400 (34%), Gaps = 34/400 (8%)

Query: 16  PIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGS-TGKRRSIFRTPSISFHHKK 74
           P F  SI+    +  S+PS ++ + +  ++  ST S + S T        TPS +     
Sbjct: 46  PSFTSSISTTETTSHSTPSFTSLITITETTSHSTPSYTTSITTTETPSHSTPSYTTSITT 105

Query: 75  GSEPKQEPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRS---- 130
              P     +   SI+      HS     S     +T    +  F+SS     T S    
Sbjct: 106 TETPSHSTPSFTSSITTTETTSHSTPSFTSSIRTTETTSYSTPSFTSSNTITETTSHSTP 165

Query: 131 --LTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTE-----DQTRRSVKQSTRKLLPK 183
             +T     E   S+  +   +  ++  +     GFT      + T  S    T  +   
Sbjct: 166 SYITSITTTETPSSSTPSFSSSITTTETTSHSTPGFTSSITTTETTSHSTPSFTSSITTT 225

Query: 184 SFSSHY--KFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSS 241
             +SH    F+  +  S++ S    S  SL  T           ++PS +  +T    +S
Sbjct: 226 ETTSHDTPSFTSSITTSETPSHSTPSSTSLITTT-----KTTSHSTPSFTSSITTTETTS 280

Query: 242 LQSPLLSADLTTAQTPSEFLALTEDSVSEMDAFSKSGSMASHCDNFGHNDSTSQMSLNSA 301
             +   ++ +TT +T S        S++  +  S S +  +         S S  S +S+
Sbjct: 281 HSAHSFTSSITTTETTSHNTRSFTSSITTTETNSHSTTSFTSSITTTETTSHSTPSFSSS 340

Query: 302 AVTKTT-------TELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAE 354
             T  T       T  T   P  +       L     T S      S+      L    +
Sbjct: 341 ITTTETXXXXXXXTSETAVTPTPVTPSS---LSTDIPTTSLRTLTPSSVGTSTSLTTTTD 397

Query: 355 LPATSVSHSESNLPADSE-REENIGLQNGET--MLGTNSP 391
            P  S+    S LP  +     +  +Q+ ET  ++GT SP
Sbjct: 398 FP--SIPTDISTLPTRTHIISSSPSIQSTETSSLVGTTSP 435


>gi|60097902 filaggrin [Homo sapiens]
          Length = 4061

 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 93/431 (21%), Positives = 148/431 (34%), Gaps = 52/431 (12%)

Query: 21   SINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQ 80
            S+++  DS   S  S    G  S +   +       G R         + H       +Q
Sbjct: 3538 SVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSRHPTSHHEDRAGHGHSAESSRQ 3597

Query: 81   EPTNQNLSISNG-AQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREK 139
              T+   + S G A   H   +  + E H      H     SSR+  I         R+ 
Sbjct: 3598 SGTHHAENSSGGQAASSHEQARSSAGERH---GSHHQQSADSSRHSGIGHGQASSAVRDS 3654

Query: 140  EHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKLLPKSFSSHYKFSKPVLQSQ 199
             H           SSG    D  G +ED   +SV  S          SH + ++     +
Sbjct: 3655 GHRG---------SSGSQASDSEGHSEDSDTQSV--SAHGQAGPHQQSHQESTRGRSAGR 3703

Query: 200  SISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQT--- 256
            S    +   F  +V+ +++ E    RA PS       R   +  S   SA      T   
Sbjct: 3704 S---GRSGSFLYQVSTHEQSESAHGRAGPSTGGRQGSRHEQARDSSRHSASQEGQDTIRG 3760

Query: 257  -PSEFLALTEDSVSE--MDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGT 313
             P       + S  E  +D    SGS  SH  + G +D++   S + +A  +T  E    
Sbjct: 3761 HPGSRRGGRQGSYHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRETRNE---- 3816

Query: 314  VPCAIMSPGKYRLEG----QCSTESNSLPETSAANQKEVLLQIAELPATSVSHSESN--L 367
                  S    R  G    + ST+++S   + +   +    + +    +SVS    +   
Sbjct: 3817 ----EQSGDGSRHSGSRHHEASTQADSSRHSQSGQGESAGSRRSRRQGSSVSQDSDSEAY 3872

Query: 368  PADSEREENIGLQN------GETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIPT 421
            P DSER      +N       ++  G+  P        H+  A HV+     SDS    T
Sbjct: 3873 PEDSERRSESASRNHHGSSREQSRDGSRHPG-----SSHRDTASHVQSSPVQSDSS---T 3924

Query: 422  SGDHHIFNKTS 432
            + +H  F+  S
Sbjct: 3925 AKEHGHFSSLS 3935



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 99/469 (21%), Positives = 162/469 (34%), Gaps = 59/469 (12%)

Query: 21   SINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQ 80
            S+++  DS   S  S    G  S +   ++      G R   F     + H       +Q
Sbjct: 1269 SVSQDSDSERHSDDSERLSGSASRNHHGSSREQSRDGSRHPGFHQEDRASHGHSADSSRQ 1328

Query: 81   EPTNQNLSISNG-AQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREK 139
              T+   S S+G A   H   +    E H     RH     SSR+  I         R+ 
Sbjct: 1329 SGTHHTESSSHGQAVSSHEQARSSPGERH---GSRHQQSADSSRHSGIGHRQASSAVRDS 1385

Query: 140  EHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKLLPKSFSSHYKFSKPVLQSQ 199
             H           SSG    +  G +ED   +SV    +         H +  K   + Q
Sbjct: 1386 GHRG---------SSGSQVTNSEGHSEDSDTQSVSAHGQA------GPHQQSHKESARGQ 1430

Query: 200  S-ISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQT-- 256
            S  S  +   F  +V+ +++ E    + +PS       R   +  S   SA      T  
Sbjct: 1431 SGESSGRSRSFLYQVSSHEQSESTHGQTAPSTGGRQGSRHEQARNSSRHSASQDGQDTIR 1490

Query: 257  --PSEFLALTEDSVSE--MDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTG 312
              P       + S  E  +D    SG   SH    G +D++   S   +A  +T  E   
Sbjct: 1491 GHPGSSRGGRQGSYHEQSVDRSGHSGYHHSHTTPQGRSDASHGQSGPRSASRQTRNE--- 1547

Query: 313  TVPCAIMSPGKYRLEG----QCSTESNSLPETSAANQKEVLLQIAELPATSVS------- 361
                   S    R  G    + ST + S   +     +    + +    +SVS       
Sbjct: 1548 -----EQSGDGSRHSGSRHHEPSTRAGSSRHSQVGQGESAGSKTSRRQGSSVSQDRDSEG 1602

Query: 362  HSE-SNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIP 420
            HSE S   ++S    + G    ++  G+ +PR    +++ +A   H         ++   
Sbjct: 1603 HSEDSERRSESASRNHYGSAREQSRHGSRNPRS---HQEDRASHGH--------SAESSR 1651

Query: 421  TSGDHHIFNKTSHGYEANPAKVLASSLSPFREGRFIERRLRSSSEGTAG 469
             SG  H   +TS G +A  ++  A S    R G   ++   SS++   G
Sbjct: 1652 QSGTRHA--ETSSGGQAASSQEQARSSPGERHGSRHQQSADSSTDSGTG 1698



 Score = 34.7 bits (78), Expect = 0.30
 Identities = 103/471 (21%), Positives = 153/471 (32%), Gaps = 62/471 (13%)

Query: 21   SINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQ 80
            S+++  DS   S  S    G  S +   +       G R         + H       +Q
Sbjct: 1917 SVSQDSDSQGHSEDSERWSGSASRNHLGSAWEQSRDGSRHPGSHHEDRAGHGHSADSSRQ 1976

Query: 81   EPTNQNLSISNG-AQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREK 139
              T    S S G A   H   +  + E H       S    SSR+  I         R+ 
Sbjct: 1977 SGTRHTESSSRGQAASSHEQARSSAGERHGSHHQLQSA--DSSRHSGIGHGQASSAVRDS 2034

Query: 140  EHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKLLPKSFSSHYKFSKPVLQSQ 199
             H            SG    D  G +ED   +SV    +         H +  K   + Q
Sbjct: 2035 GHRGY---------SGSQASDSEGHSEDSDTQSVSAQGKA------GPHQQSHKESARGQ 2079

Query: 200  S-ISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQT-- 256
            S  S  +   F  +V+ +++ E    +++PS           +  S   SA      T  
Sbjct: 2080 SGESSGRSGSFLYQVSTHEQSESTHGQSAPSTGGRQGSHYDQAQDSSRHSASQEGQDTIR 2139

Query: 257  ----PSEFLALTEDSVSEMDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKT-TTELT 311
                PS            +D    SGS  SH  + G +D++   S + +A  KT   E +
Sbjct: 2140 GHPGPSRGGRQGSHQEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRKTYDKEQS 2199

Query: 312  G------------TVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATS 359
            G                A  S      +GQ S    S P  S+ +Q           + S
Sbjct: 2200 GDGSRHSGSHHHEASSWADSSRHSLVGQGQSSGPRTSRPRGSSVSQ----------DSDS 2249

Query: 360  VSHSE-SNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKI 418
              HSE S   + S    + G    ++  G+  PR       H+  A H    H    S+ 
Sbjct: 2250 EGHSEDSERRSGSASRNHHGSAQEQSRDGSRHPR-----SHHEDRAGHG---HSAESSR- 2300

Query: 419  IPTSGDHHIFNKTSHGYEANPAKVLASSLSPFREGRFIERRLRSSSEGTAG 469
               SG HH  N  S G +A  +   A S +  R G   ++   SS     G
Sbjct: 2301 --QSGTHHAEN--SSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIG 2347



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 62/300 (20%), Positives = 102/300 (34%), Gaps = 32/300 (10%)

Query: 21   SINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQ 80
            S+++  DS   S  S    G  S +   +       G R         + H       +Q
Sbjct: 2242 SVSQDSDSEGHSEDSERRSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAESSRQ 2301

Query: 81   EPTNQNLSISNG-AQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREK 139
              T+   + S G A   H   +  + E H      H     SSR+  I         R+ 
Sbjct: 2302 SGTHHAENSSGGQAASSHEQARSSAGERH---GSHHQQSADSSRHSGIGHGQASSAVRDS 2358

Query: 140  EHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKLLPKSFSSHYKFSKPVLQSQ 199
             H           SSG    D  G +ED   +SV  S          SH + ++     +
Sbjct: 2359 GHRG---------SSGSQASDSEGHSEDSDTQSV--SAHGQAGPHQQSHQESTRGRSAGR 2407

Query: 200  SISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSE 259
            S    +   F  +V+ +++ E    R   S       R GS  +    S+  +T+Q   +
Sbjct: 2408 S---GRSGSFLYQVSTHEQSESAHGRTGTSTG----GRQGSHHKQARDSSRHSTSQEGQD 2460

Query: 260  FLALTEDSVSE----------MDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTE 309
             +     S S           +D    SGS  SH  + G +D++   S + +A  +T  +
Sbjct: 2461 TIHGHPGSSSGGRQGSHYEQLVDRSGHSGSHHSHTTSQGRSDASHGHSGSRSASRQTRND 2520



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 31/122 (25%), Positives = 47/122 (38%), Gaps = 3/122 (2%)

Query: 2    GDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRS 61
            G SGSR ++  +R     R  +R   S     SS   +  HS +    +  S ++ ++ S
Sbjct: 885  GQSGSRSASRTTRNEEQSRDGSRHSGSRHHEASSHADISRHSQAGQGQSEGSRTSRRQGS 944

Query: 62   IFRTPSISFHHKKGSEPKQEPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSS 121
                 S S  H + SE      ++N   S   Q  H +    S   H + R  H     S
Sbjct: 945  SVSQDSDSEGHSEDSERWSGSASRNHRGSAQEQSRHGSRHPRS---HHEDRAGHGHSADS 1001

Query: 122  SR 123
            SR
Sbjct: 1002 SR 1003



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 47/214 (21%), Positives = 72/214 (33%), Gaps = 54/214 (25%)

Query: 2    GDSGSRRSTLVSRL-----PIFRRSINRRHDSLPSSPSSSNTVGVHSSSP---------S 47
            G SGSR ++  +R         R S++R H++   +  S ++  V   S          S
Sbjct: 3154 GQSGSRSASRTTRNEEQSGDSSRHSVSRHHEASTHADISRHSQAVQGQSEGSRRSRRQGS 3213

Query: 48   STNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQ--------------------------E 81
            S +  S S G      R    +  + +GS  +Q                          +
Sbjct: 3214 SVSQDSDSEGHSEDSERWSGSASRNHRGSVQEQSRHGSRHPRSHHEDRAGHGHSADRSRQ 3273

Query: 82   PTNQNLSISNGAQPGHSNMQKLSL--EEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREK 139
               ++   S+G Q   S+ Q  S   E H     RH     SSR+  I R       R+ 
Sbjct: 3274 SGTRHAETSSGGQAASSHEQARSSPGERH---GSRHQQSADSSRHSGIPRGQASSAVRDS 3330

Query: 140  EHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSV 173
             H           SSG    D  G +E+   +SV
Sbjct: 3331 RHWG---------SSGSQASDSEGHSEESDTQSV 3355


>gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithorax
           homolog, Drosophila); translocated to, 3 [Homo sapiens]
          Length = 568

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 68/287 (23%), Positives = 116/287 (40%), Gaps = 26/287 (9%)

Query: 28  SLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNL 87
           S  SS SSS++    SSS SS++SSS S+    S   + S S  HK   E K++P+  + 
Sbjct: 153 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSR 212

Query: 88  SISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLT--EDFEREKEHSTNK 145
              +  +    +  K S E   K +    +     + +KI   +   E     KE   + 
Sbjct: 213 EHKSAFKEPSRDHNKSSKESSKKPKENKPL-----KEEKIVPKMAFKEPKPMSKEPKPDS 267

Query: 146 NVFINCLSSGKSEGDDS-----GFTEDQTRRSVKQSTRKLLPKSFSSH----YKFSKPVL 196
           N+    ++SG+ +   S       +E+ + +  K+S+ + L KSFSS        S    
Sbjct: 268 NLL--TITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKK 325

Query: 197 QSQSISLVQQSEFSLEVTQYQEREPVLVR----ASPSCSVDVTERAGSSLQSPLLSADLT 252
           Q +  S V+  +  +E    ++++  L        P+ S DV E   S   S   S   +
Sbjct: 326 QIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDS-DVEENISSKSDSEQPSPASS 384

Query: 253 TAQTPSEFLALTEDSVSEMDAFSK---SGSMASHCDNFGHNDSTSQM 296
           ++ + S F          + +  K   S       D    ND+ S+M
Sbjct: 385 SSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDSEM 431


>gi|40068059 CBF1 interacting corepressor [Homo sapiens]
          Length = 450

 Score = 40.0 bits (92), Expect = 0.007
 Identities = 43/159 (27%), Positives = 68/159 (42%), Gaps = 15/159 (9%)

Query: 20  RSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKR--RSIFRTPSISFHHKKGSE 77
           RS +++H S  SS SSS++     +S SS+ S S +  K+  R   +    S H+   SE
Sbjct: 249 RSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSE 308

Query: 78  PKQEPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFER 137
            K +   + L         H N +K       K + R     SS  + K + S ++   R
Sbjct: 309 EKDKSKKRKL--HEELSSSHHNREK------AKEKPRFLKHESSREDSKWSHSDSDKKSR 360

Query: 138 EKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQS 176
             +HS  K        S +S G      E+++RRS  +S
Sbjct: 361 THKHSPEKRGSERKEGSSRSHG-----REERSRRSRSRS 394


>gi|33356174 pinin, desmosome associated protein [Homo sapiens]
          Length = 717

 Score = 39.7 bits (91), Expect = 0.009
 Identities = 40/161 (24%), Positives = 67/161 (41%), Gaps = 25/161 (15%)

Query: 20  RSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPK 79
           RS +R      +S S S +    SSS SST+SSSGS+                  GS   
Sbjct: 559 RSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSS---------------SSGSSSS 603

Query: 80  QEPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSR--NKKITRSLTEDFER 137
           +  ++ + S S  +    S+    S E   ++RGR   G +  R   + + R   +    
Sbjct: 604 RSSSSSSSSTSGSSSRDSSSSTSSSSESRSRSRGR---GHNRDRKHRRSVDRKRRDTSGL 660

Query: 138 EKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTR 178
           E+ H ++K       SS  ++G     +    +RS+ +S+R
Sbjct: 661 ERSHKSSKGG-----SSRDTKGSKDKNSRSDRKRSISESSR 696



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 41/155 (26%), Positives = 65/155 (41%), Gaps = 6/155 (3%)

Query: 20  RSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPK 79
           R+ N+   S   S SSS++    +SS S ++SSSGS+  R S   + S S    + S   
Sbjct: 565 RARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSS 624

Query: 80  QEPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREK 139
              ++++ S S G   GH+  +K       K R    +  S   +K  +   T+  + + 
Sbjct: 625 TSSSSESRSRSRGR--GHNRDRKHRRSVDRKRRDTSGLERSHKSSKGGSSRDTKGSKDKN 682

Query: 140 EHSTNKNVFINCLSSGK----SEGDDSGFTEDQTR 170
             S  K        SGK    SE D     +D+ R
Sbjct: 683 SRSDRKRSISESSRSGKRSSRSERDRKSDRKDKRR 717


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 39.7 bits (91), Expect = 0.009
 Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 16/136 (11%)

Query: 22  INRRHDSLPSSPSSSNTVGVH---SSSPSSTNSSSGSTGKRRSIFRTPSISFHH------ 72
           ++R   S P SP  +   G H   SSSP+S N S G   + +S   TPS           
Sbjct: 430 VSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPAT 489

Query: 73  -KKGSEPKQEPTNQNLSISNGAQPGHS-NMQKLSLEEHIKTRGR----HSVGFSSSRNKK 126
            K+G    + PT +  S S   Q   S + Q+       + RGR       G+S SRN +
Sbjct: 490 AKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQ 549

Query: 127 ITRSLTEDFEREKEHS 142
             R  +    R + HS
Sbjct: 550 -RRGRSRSARRGRSHS 564



 Score = 33.9 bits (76), Expect = 0.51
 Identities = 53/210 (25%), Positives = 80/210 (38%), Gaps = 30/210 (14%)

Query: 40   GVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSISNGAQPGHSN 99
            G HS SP+   SS  S+ +RR   RTP  S   +K S  +  P            P   +
Sbjct: 1819 GYHSRSPARQESSRTSSRRRRGRSRTPPTS---RKRSRSRTSPA-----------PWKRS 1864

Query: 100  MQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEG 159
              + S   H ++R R  +  S  R++  T  ++    R +   T +       +S  S  
Sbjct: 1865 RSRASPATHRRSRSRTPL-ISRRRSRSRTSPVSRRRSRSRTSVTRRR--SRSRASPVSRR 1921

Query: 160  DDSGFTEDQTRRSVKQSTRKLLPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQER 219
                 T   TRR  +  T     +S S     + PV + +S S          VT+ + R
Sbjct: 1922 RSRSRTPPVTRRRSRSRTPTTRRRSRSR----TPPVTRRRSRSRTP------PVTRRRSR 1971

Query: 220  ---EPVLVRASPSCSVDVTERAGSSLQSPL 246
                P+  R S S +  VT R   S  SP+
Sbjct: 1972 SRTSPITRRRSRSRTSPVTRRRSRSRTSPV 2001



 Score = 33.9 bits (76), Expect = 0.51
 Identities = 31/130 (23%), Positives = 51/130 (39%), Gaps = 12/130 (9%)

Query: 13   SRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHH 72
            S L   + +  RR  S  SS SSS++    SSS SS++ SS S  +  S+   P ++   
Sbjct: 2519 SALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKR 2578

Query: 73   ------------KKGSEPKQEPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFS 120
                        ++G  P+  P  +    S+ +    S+    S      +    S   S
Sbjct: 2579 VPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2638

Query: 121  SSRNKKITRS 130
            SS +   + S
Sbjct: 2639 SSSSSSSSSS 2648



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 21/61 (34%), Positives = 31/61 (50%)

Query: 24   RRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPT 83
            +R  S  SS SSS++    SSS SS++SSS S+    S   + S     K G +   +P 
Sbjct: 2604 KRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPA 2663

Query: 84   N 84
            +
Sbjct: 2664 S 2664



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 4/76 (5%)

Query: 19   RRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHH----KK 74
            +R       S  SS SSS++    SSS SS++SSS S+    S   +PS +        K
Sbjct: 2602 KRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPK 2661

Query: 75   GSEPKQEPTNQNLSIS 90
             + PK+ P  +  S S
Sbjct: 2662 PASPKKPPPGERRSRS 2677


>gi|239752529 PREDICTED: similar to mucin [Homo sapiens]
          Length = 594

 Score = 38.5 bits (88), Expect = 0.021
 Identities = 81/362 (22%), Positives = 126/362 (34%), Gaps = 43/362 (11%)

Query: 16  PIFRRSINRRHDSLPSSPSSSNTVGV-HSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKK 74
           P F  SI        S PS ++ +    S+S S  + +S  T    +   TPS +     
Sbjct: 103 PSFTSSIATTETPSHSPPSFTSLITTTESTSHSPLSFTSVITTTESTSHSTPSFTSSIAT 162

Query: 75  GSEPKQEPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTED 134
                  P +    I+    P HSN    SL    ++       F+S+     T  +T  
Sbjct: 163 TETTSHTPPSFTSLITTTETPSHSNPSFTSLITATESTSHSPPSFTSAI---ATTGITS- 218

Query: 135 FEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKLLPKSFSSHY--KFS 192
                 HST   +F + ++           T D T  S    T  +      SH    FS
Sbjct: 219 ------HSTP--IFTSLIA-----------TTDSTSHSTPSFTSSITSTETISHSTPSFS 259

Query: 193 KPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLT 252
             +  +++ S    S  SL  T           ++PS +  VT    +S  +P  ++ +T
Sbjct: 260 SLITATKTTSHSTPSLTSLITTTNTSH------STPSLTSLVTSTETASHSTPSFTSLIT 313

Query: 253 TAQTPSEFLALTEDSVSEMDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTT--EL 310
           T +  S        S++     S S    ++      + S S  SL SA  T  T    +
Sbjct: 314 TIEATSHSTPSLTSSITTTGTTSHSTPSFTYLTTITESTSHSTPSLTSAITTTETMSHSI 373

Query: 311 TGTVPCAI--MSPGKYRLEGQCSTESNSLPE-------TSAANQKEVLLQIAELPATSVS 361
            G  P  I   +P    L     T S+S P        T +A+     L  A     ++S
Sbjct: 374 LGFTPSIISPSTPSYISLIATTETPSHSTPSFPSSITTTQSASHSTPSLTSAISTTEAMS 433

Query: 362 HS 363
           HS
Sbjct: 434 HS 435



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 58/303 (19%), Positives = 109/303 (35%), Gaps = 22/303 (7%)

Query: 28  SLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRT--------PSISFHHKKGSEPK 79
           ++ ++ + S++  + +SS ++  ++S ST    S+  T        P+ +F         
Sbjct: 40  AITTTETRSHSPPIFTSSITTIETTSHSTPSFTSLMTTTETTSLSPPAFTFSISTTETNS 99

Query: 80  QEPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSS-----SRNKKITRSLTED 134
             P +   SI+    P HS     SL    ++     + F+S           T S T  
Sbjct: 100 HSPPSFTSSIATTETPSHSPPSFTSLITTTESTSHSPLSFTSVITTTESTSHSTPSFTSS 159

Query: 135 FEREKEHSTNKNVFINCLSSGKSEG-DDSGFTE-----DQTRRSVKQSTRKLLPKSFSSH 188
               +  S     F + +++ ++    +  FT      + T  S    T  +     +SH
Sbjct: 160 IATTETTSHTPPSFTSLITTTETPSHSNPSFTSLITATESTSHSPPSFTSAIATTGITSH 219

Query: 189 YKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLS 248
              S P+  S   +    S  +   T        +  ++PS S  +T    +S  +P L+
Sbjct: 220 ---STPIFTSLIATTDSTSHSTPSFTSSITSTETISHSTPSFSSLITATKTTSHSTPSLT 276

Query: 249 ADLTTAQTPSEFLALTEDSVSEMDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTT 308
           + +TT  T     +LT    S   A   + S  S          ++    +S   T TT+
Sbjct: 277 SLITTTNTSHSTPSLTSLVTSTETASHSTPSFTSLITTIEATSHSTPSLTSSITTTGTTS 336

Query: 309 ELT 311
             T
Sbjct: 337 HST 339


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
           [Homo sapiens]
          Length = 1481

 Score = 38.5 bits (88), Expect = 0.021
 Identities = 38/156 (24%), Positives = 60/156 (38%), Gaps = 2/156 (1%)

Query: 19  RRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEP 78
           +RS++       SS   S +    S SP     SS     +RS+ R+P  S   K     
Sbjct: 299 QRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPS--RKSMKSR 356

Query: 79  KQEPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFERE 138
            + P     S S+  +   S+  + S    ++     S+G   SR KK   +     + +
Sbjct: 357 SRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMD 416

Query: 139 KEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVK 174
            + S    VF+    +   E  DSG    +  RSVK
Sbjct: 417 GKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVK 452


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
           [Homo sapiens]
          Length = 1490

 Score = 38.5 bits (88), Expect = 0.021
 Identities = 38/156 (24%), Positives = 60/156 (38%), Gaps = 2/156 (1%)

Query: 19  RRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEP 78
           +RS++       SS   S +    S SP     SS     +RS+ R+P  S   K     
Sbjct: 299 QRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPS--RKSMKSR 356

Query: 79  KQEPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFERE 138
            + P     S S+  +   S+  + S    ++     S+G   SR KK   +     + +
Sbjct: 357 SRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMD 416

Query: 139 KEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVK 174
            + S    VF+    +   E  DSG    +  RSVK
Sbjct: 417 GKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVK 452


>gi|50962882 G patch domain containing 8 [Homo sapiens]
          Length = 1502

 Score = 38.1 bits (87), Expect = 0.027
 Identities = 60/247 (24%), Positives = 96/247 (38%), Gaps = 30/247 (12%)

Query: 3   DSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSS--PSSTNSSSGSTGKRR 60
           D   RRS     LP    S  ++ +    S S  +    H     PSS    +G+    R
Sbjct: 752 DDSQRRS-----LPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSR 806

Query: 61  SIFRTPSISFHHKKGSEPKQEPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFS 120
           S  R+   S     G E   + ++  L   + +Q      ++ S  EH ++R R     S
Sbjct: 807 SSHRSQPSS-----GDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHS 861

Query: 121 SSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDS-GFTEDQTRRSVKQS--- 176
           S R+ + + S + D   ++          +C S  +S  DDS     D++RR  K+S   
Sbjct: 862 SHRSSRRSYSSSSDASSDQ----------SCYSRQRSYSDDSYSDYSDRSRRHSKRSHDS 911

Query: 177 --TRKLLPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDV 234
             +     K  S  +K+S       S+S  Q    S   T+ + R     R+S SCS   
Sbjct: 912 DDSDYASSKHRSKRHKYSSSD-DDYSLSCSQSRSRSRSHTRERSRSRGRSRSS-SCSRSR 969

Query: 235 TERAGSS 241
           ++R   S
Sbjct: 970 SKRRSRS 976


>gi|67782356 corneodesmosin precursor [Homo sapiens]
          Length = 529

 Score = 37.7 bits (86), Expect = 0.035
 Identities = 38/100 (38%), Positives = 46/100 (46%), Gaps = 19/100 (19%)

Query: 29  LPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQN-- 86
           L SS S S + G HS S SS +SSS S       F+  S SF    GS     PTN N  
Sbjct: 134 LGSSSSHSGSSGSHSGSSSSHSSSSSS-------FQFSSSSFQVGNGS---ALPTNDNSY 183

Query: 87  LSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKK 126
             I N +QPG S+          +T G  S G S S N++
Sbjct: 184 RGILNPSQPGQSSSSS-------QTFGVSSSGQSVSSNQR 216


>gi|196114970 protein tyrosine phosphatase, non-receptor type 12
           isoform 3 [Homo sapiens]
          Length = 650

 Score = 37.4 bits (85), Expect = 0.046
 Identities = 51/233 (21%), Positives = 91/233 (39%), Gaps = 21/233 (9%)

Query: 143 TNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKLLPKSFSSHYKFSKPVLQSQSIS 202
           T++N  ++C  +  ++   +   E Q   +  +  R  L +     + F  P     +I 
Sbjct: 360 TSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGP---ENAIP 416

Query: 203 LVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLA 262
           +   SE +     YQ R+ V +  SP+  V+  +       SPL        +TP  F  
Sbjct: 417 IPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLF-------RTPLSFTN 469

Query: 263 LTEDSVSEMDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPG 322
                 S+ D  +  G++  +  N     ST+  ++++A    T+TE   T     MS  
Sbjct: 470 PLHSDDSDSDERNSDGAVTQNKTNI----STASATVSAA----TSTESISTRKVLPMSIA 521

Query: 323 KYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSVSHSESNLPADSEREE 375
           ++ + G  +T S +  +   +      L     P + V  SE N P  SE  E
Sbjct: 522 RHNIAG--TTHSGAEKDVDVSEDSPPPLP-ERTPESFVLASEHNTPVRSEWSE 571


>gi|196114967 protein tyrosine phosphatase, non-receptor type 12
           isoform 2 [Homo sapiens]
          Length = 661

 Score = 37.4 bits (85), Expect = 0.046
 Identities = 51/233 (21%), Positives = 91/233 (39%), Gaps = 21/233 (9%)

Query: 143 TNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKLLPKSFSSHYKFSKPVLQSQSIS 202
           T++N  ++C  +  ++   +   E Q   +  +  R  L +     + F  P     +I 
Sbjct: 371 TSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGP---ENAIP 427

Query: 203 LVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLA 262
           +   SE +     YQ R+ V +  SP+  V+  +       SPL        +TP  F  
Sbjct: 428 IPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLF-------RTPLSFTN 480

Query: 263 LTEDSVSEMDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPG 322
                 S+ D  +  G++  +  N     ST+  ++++A    T+TE   T     MS  
Sbjct: 481 PLHSDDSDSDERNSDGAVTQNKTNI----STASATVSAA----TSTESISTRKVLPMSIA 532

Query: 323 KYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSVSHSESNLPADSEREE 375
           ++ + G  +T S +  +   +      L     P + V  SE N P  SE  E
Sbjct: 533 RHNIAG--TTHSGAEKDVDVSEDSPPPLP-ERTPESFVLASEHNTPVRSEWSE 582


>gi|196114951 protein tyrosine phosphatase, non-receptor type 12
           isoform 1 [Homo sapiens]
          Length = 780

 Score = 37.4 bits (85), Expect = 0.046
 Identities = 51/233 (21%), Positives = 91/233 (39%), Gaps = 21/233 (9%)

Query: 143 TNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKLLPKSFSSHYKFSKPVLQSQSIS 202
           T++N  ++C  +  ++   +   E Q   +  +  R  L +     + F  P     +I 
Sbjct: 490 TSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGP---ENAIP 546

Query: 203 LVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLA 262
           +   SE +     YQ R+ V +  SP+  V+  +       SPL        +TP  F  
Sbjct: 547 IPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLF-------RTPLSFTN 599

Query: 263 LTEDSVSEMDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPG 322
                 S+ D  +  G++  +  N     ST+  ++++A    T+TE   T     MS  
Sbjct: 600 PLHSDDSDSDERNSDGAVTQNKTNI----STASATVSAA----TSTESISTRKVLPMSIA 651

Query: 323 KYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSVSHSESNLPADSEREE 375
           ++ + G  +T S +  +   +      L     P + V  SE N P  SE  E
Sbjct: 652 RHNIAG--TTHSGAEKDVDVSEDSPPPLP-ERTPESFVLASEHNTPVRSEWSE 701


>gi|59710093 G-protein coupled receptor 112 [Homo sapiens]
          Length = 3080

 Score = 37.4 bits (85), Expect = 0.046
 Identities = 53/245 (21%), Positives = 100/245 (40%), Gaps = 13/245 (5%)

Query: 140 EHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKLLPKSFSSHYKFSKPVLQSQ 199
           +H      F+ CL       ++  +  ++   +V ++ R  +P++ +      K    SQ
Sbjct: 189 DHILENEEFMKCLDGNIVSWEEDVWLVNKIIPTVDRTLRCFVPENMTIQ---EKSTTVSQ 245

Query: 200 SISLVQQSEFSLEVTQYQEREPVLVRAS-PSCSVDVTERAGSSLQSPLLSADLTTAQTPS 258
            I +   S+ +    Q       L+  S P  + D T  + S+  SP L  +  TAQ   
Sbjct: 246 QIDMTTPSQITGVKPQNTAHSSTLLSQSIPIFATDYTTISYSNTTSPPL--ETMTAQKIL 303

Query: 259 EFLALTEDSVSEMDAFSKSGSMASHCDNFGHNDSTSQMSLN---SAAVTKTT--TELTGT 313
           + L + E +   +D  S S +++    +   +++T+ M      S+  TKTT   E   T
Sbjct: 304 KTL-VDETATFAVDVLSTSSAISLPTQSISIDNTTNSMKKTKSPSSESTKTTKMVEAMAT 362

Query: 314 VPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSVSHSESNLPADSER 373
                 +P  + L     T+++ +  TSA   +  + +   L +T  S S S  P   ++
Sbjct: 363 EIFQPPTPSNF-LSTSRFTKNSVVSTTSAIKSQSAVTKTTSLFSTIESTSMSTTPCLKQK 421

Query: 374 EENIG 378
             N G
Sbjct: 422 STNTG 426


>gi|55741677 SET domain containing 1A [Homo sapiens]
          Length = 1707

 Score = 37.0 bits (84), Expect = 0.060
 Identities = 57/235 (24%), Positives = 81/235 (34%), Gaps = 41/235 (17%)

Query: 60   RSIFRTPSISFHHKKGSE--------------PKQEPTNQNLSISNGAQPGHSNMQKLSL 105
            R   R PS     K+ SE              P +E  +         +PG    +    
Sbjct: 885  RGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKR 944

Query: 106  -EEHIKTRGRHSVGF-------------SSSRNKKITRSLTEDFEREKEHSTNKNVFINC 151
             EE  KT+G+H   F             SS ++++      ED +RE+   T K      
Sbjct: 945  DEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKE--TE 1002

Query: 152  LSSGKSEGDDSGFTEDQTRRSVKQSTRKLLPKSFSSHYKFSKPVLQSQSISLVQQSEFSL 211
            +S G+ E  DS         S  ++      +S SS    S     S S S    SE S 
Sbjct: 1003 VSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSS 1062

Query: 212  EVTQYQEREPVLVRASP-----------SCSVDVTERAGSSLQSPLLSADLTTAQ 255
            E  + +ER   L  ASP              V V ER   S  +PL   + + A+
Sbjct: 1063 EDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPAR 1117


>gi|62988361 absent in melanoma 1 [Homo sapiens]
          Length = 1723

 Score = 37.0 bits (84), Expect = 0.060
 Identities = 118/556 (21%), Positives = 213/556 (38%), Gaps = 87/556 (15%)

Query: 93  AQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFI--- 149
           A+P H  +  L   +++ + G     FS   +K  T +    FE ++ +S+ ++  I   
Sbjct: 235 AKPKHVELN-LKTPKNLDSLGNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIRGQ 293

Query: 150 -NCLSSGKSEGDDSGFTEDQTRRSVKQSTRKLLPKSFSSHYKFSKPVLQSQSISLVQQSE 208
            N  +S K+    +     +  + ++Q  +K++P S              Q+  LV+++ 
Sbjct: 294 RNTPASSKTFVGRAKLNLAKKAKEMEQPEKKVMPNS-------------PQNGVLVKETA 340

Query: 209 FSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQ-SPLLSADLTT-AQTPSEFLALTED 266
              +VT  +E    ++ A+   + D +E      Q +    AD+ T A   SE +A    
Sbjct: 341 IETKVTVSEEE---ILPATRGMNGDSSENQALGPQPNQDDKADVQTDAGCLSEPVASALI 397

Query: 267 SVSEMDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPGKYRL 326
            V +     K  S A+   +    + T     ++A    TT +     P A+  P     
Sbjct: 398 PVKDHKLLEKEDSEAADSKSLVLENVT-----DTAQDIPTTVDTKDLPPTAMPKPQHTFS 452

Query: 327 EGQCSTESNSLPETSAANQ------KEVLLQ--IAELPATSVSHSESN----LPADSERE 374
           + Q   ES+  P  S +        K+  +Q  I+  P T +  SE++    LP   +  
Sbjct: 453 DSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISSFPCTDLKVSENHKGCVLPVSRQNN 512

Query: 375 ENIGLQN--GETM--LGTN-SPRKLGFYEQHKAIAEHVKGIHPISD-----SKIIPTSGD 424
           E + L    GET   L T  SP  +G     + + +    + P+       S++IP S +
Sbjct: 513 EKMPLLELGGETTPPLSTERSPEAVGSECPSRVLVQVRSFVLPVESTQDVSSQVIPESSE 572

Query: 425 -HHIFNKTSHGYEANPAKVLASSLSPFREGRFIERRLRSSSEGTAGSSRMILKPKDGNIE 483
              +   T H  E  P  V  +S +P +E          ++E  A S   ++ P     E
Sbjct: 573 VREVQLPTCHSNE--PEVVSVASCAPPQEEVLGNEHSHCTAELAAKSGPQVIPPAS---E 627

Query: 484 EVNSLRKQRAGS------SSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCR 537
           +   ++ Q  GS       SS  NS    N+L + +   D  + + +      L+ S   
Sbjct: 628 KTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLATPQRP-DQTVTNGQDSPASLLNISAGS 686

Query: 538 EDSYHSVVSCAAVVLTPMEPMIEMKKREEPEFPEPSKQNLSLKLTKDVDQEARCSHISRM 597
           +DS     S        ME   E+ K+ +     P K+  +                 RM
Sbjct: 687 DDSVFDSSS-------DMEKFTEIIKQMDSAVCMPMKRKKA-----------------RM 722

Query: 598 PNSPSADWPLQGVEEN 613
           PNSP+  + +  + E+
Sbjct: 723 PNSPAPHFAMPPIHED 738


>gi|21314720 Smad nuclear interacting protein [Homo sapiens]
          Length = 396

 Score = 37.0 bits (84), Expect = 0.060
 Identities = 31/123 (25%), Positives = 48/123 (39%), Gaps = 7/123 (5%)

Query: 40  GVHSSSPSSTNSSSGSTGKR-RSIFRTPSISFHHKKGSEPKQEPTNQNLSISNGAQPGHS 98
           G   S P+S  + SG  G R R + R+P    +   G   K   + +N S      P HS
Sbjct: 50  GGSPSPPTSEPARSGHRGNRARGVSRSPPKKKNKASGRRSKSPRSKRNRS------PHHS 103

Query: 99  NMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSE 158
            ++     E    RGR          ++  R+   D +R + HS  +        SG+ +
Sbjct: 104 TVKVKQEREDHPRRGREDRQHREPSEQEHRRARNSDRDRHRGHSHQRRTSNERPGSGQGQ 163

Query: 159 GDD 161
           G D
Sbjct: 164 GRD 166


>gi|188497758 ubiquitin associated protein 2-like isoform a [Homo
           sapiens]
          Length = 1087

 Score = 37.0 bits (84), Expect = 0.060
 Identities = 77/412 (18%), Positives = 146/412 (35%), Gaps = 47/412 (11%)

Query: 30  PSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSI 89
           PSSP  S +      SP S+++ S S    +       +    KK S   + P    L++
Sbjct: 452 PSSPLPSKSTSAPQMSPGSSDNQSSSPQPAQQ-----KLKQQKKKASLTSKIPA---LAV 503

Query: 90  SNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFI 149
                PG +++  L+L+      G   V                D+E     S + +   
Sbjct: 504 E---MPGSADISGLNLQFGALQFGSEPV--------------LSDYESTPTTSASSSQAP 546

Query: 150 NCLSSGKSEGDDSGFTEDQTRRSVKQSTRKLLPKSFSSHYKFSKPVLQSQSISLVQQSEF 209
           + L +  +    S  + +Q++ S  QS   +   +++S      P+ + +S         
Sbjct: 547 SSLYTSTASESSSTISSNQSQESGYQS-GPIQSTTYTSQNNAQGPLYEQRSTQ------- 598

Query: 210 SLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVS 269
                    R P  + +SP   +   +   SS+Q+  L    +        +     S S
Sbjct: 599 -------TRRYPSSISSSPQKDLTQAKNGFSSVQATQLQTTQSVEGATGSAVKSDSPSTS 651

Query: 270 EMDAFSKSGSMASHCDNFG-HNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPGKYRLEG 328
            +   +++ S AS       H+ S   +S +      TTT+ + T+     +       G
Sbjct: 652 SIPPLNETVSAASLLTTTNQHSSSLGGLSHSEEIPNTTTTQHSSTLSTQQNTLSSSTSSG 711

Query: 329 QCSTESNSLPETSAANQKEVLLQIAELPATSVSHSES----NLPADSEREENIGLQNGET 384
           + ST  ++L  TS  ++  +    +    TS + S      ++ +      ++GL  G  
Sbjct: 712 RTST--STLLHTSVESEANLHSSSSTFSTTSSTVSAPPPVVSVSSSLNSGSSLGLSLGSN 769

Query: 385 MLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIPTSGDHHIFNKTSHGYE 436
              T S R        KA      G+ P+  +  I   G  H +    +GY+
Sbjct: 770 STVTASTRSSVATTSGKAPPNLPPGVPPLLPNPYIMAPGLLHAYPPQVYGYD 821


>gi|188497756 ubiquitin associated protein 2-like isoform b [Homo
           sapiens]
          Length = 983

 Score = 37.0 bits (84), Expect = 0.060
 Identities = 77/412 (18%), Positives = 146/412 (35%), Gaps = 47/412 (11%)

Query: 30  PSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSI 89
           PSSP  S +      SP S+++ S S    +       +    KK S   + P    L++
Sbjct: 452 PSSPLPSKSTSAPQMSPGSSDNQSSSPQPAQQ-----KLKQQKKKASLTSKIPA---LAV 503

Query: 90  SNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFI 149
                PG +++  L+L+      G   V                D+E     S + +   
Sbjct: 504 E---MPGSADISGLNLQFGALQFGSEPV--------------LSDYESTPTTSASSSQAP 546

Query: 150 NCLSSGKSEGDDSGFTEDQTRRSVKQSTRKLLPKSFSSHYKFSKPVLQSQSISLVQQSEF 209
           + L +  +    S  + +Q++ S  QS   +   +++S      P+ + +S         
Sbjct: 547 SSLYTSTASESSSTISSNQSQESGYQS-GPIQSTTYTSQNNAQGPLYEQRSTQ------- 598

Query: 210 SLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVS 269
                    R P  + +SP   +   +   SS+Q+  L    +        +     S S
Sbjct: 599 -------TRRYPSSISSSPQKDLTQAKNGFSSVQATQLQTTQSVEGATGSAVKSDSPSTS 651

Query: 270 EMDAFSKSGSMASHCDNFG-HNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPGKYRLEG 328
            +   +++ S AS       H+ S   +S +      TTT+ + T+     +       G
Sbjct: 652 SIPPLNETVSAASLLTTTNQHSSSLGGLSHSEEIPNTTTTQHSSTLSTQQNTLSSSTSSG 711

Query: 329 QCSTESNSLPETSAANQKEVLLQIAELPATSVSHSES----NLPADSEREENIGLQNGET 384
           + ST  ++L  TS  ++  +    +    TS + S      ++ +      ++GL  G  
Sbjct: 712 RTST--STLLHTSVESEANLHSSSSTFSTTSSTVSAPPPVVSVSSSLNSGSSLGLSLGSN 769

Query: 385 MLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIPTSGDHHIFNKTSHGYE 436
              T S R        KA      G+ P+  +  I   G  H +    +GY+
Sbjct: 770 STVTASTRSSVATTSGKAPPNLPPGVPPLLPNPYIMAPGLLHAYPPQVYGYD 821


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 2542

 Score = 36.6 bits (83), Expect = 0.078
 Identities = 42/178 (23%), Positives = 71/178 (39%), Gaps = 12/178 (6%)

Query: 30   PSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSI 89
            P S +++ T+G+ ++S + TN       KR ++  TPS +  +KK    +  PT   +  
Sbjct: 1506 PPSATTTTTIGISATSATFTNVFGK---KRANVVTTPSTNRKNKKNKTKETPPTAHLILP 1562

Query: 90   SNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFI 149
                        K  +    + RG  + G S S N   T   +E     K    N   F+
Sbjct: 1563 EQHMSLAQQKADKNKING--EPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELN---FV 1617

Query: 150  NCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL----LPKSFSSHYKFSKPVLQSQSISL 203
              ++S K         E++T  +  ++  +L     P S S+ YK     L S +I L
Sbjct: 1618 MDVNSSKYPSLLLHSQEEKTSTATSKTQTRLEGEVTPNSLSTSYKTVSLPLSSPNIKL 1675


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score = 36.6 bits (83), Expect = 0.078
 Identities = 42/178 (23%), Positives = 71/178 (39%), Gaps = 12/178 (6%)

Query: 30   PSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSI 89
            P S +++ T+G+ ++S + TN       KR ++  TPS +  +KK    +  PT   +  
Sbjct: 1506 PPSATTTTTIGISATSATFTNVFGK---KRANVVTTPSTNRKNKKNKTKETPPTAHLILP 1562

Query: 90   SNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFI 149
                        K  +    + RG  + G S S N   T   +E     K    N   F+
Sbjct: 1563 EQHMSLAQQKADKNKING--EPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELN---FV 1617

Query: 150  NCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL----LPKSFSSHYKFSKPVLQSQSISL 203
              ++S K         E++T  +  ++  +L     P S S+ YK     L S +I L
Sbjct: 1618 MDVNSSKYPSLLLHSQEEKTSTATSKTQTRLEGEVTPNSLSTSYKTVSLPLSSPNIKL 1675


>gi|154146223 splicing factor, arginine/serine-rich 130 [Homo
           sapiens]
          Length = 805

 Score = 36.6 bits (83), Expect = 0.078
 Identities = 32/125 (25%), Positives = 54/125 (43%), Gaps = 13/125 (10%)

Query: 21  SINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQ 80
           S N R  S  S+ SSS+      SS +S+ SSS    KR S  R+P+I     K    + 
Sbjct: 519 SSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTI-----KARRSRS 573

Query: 81  EPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKE 140
              ++ + I        SN  ++ + +  +   R+S+     RN+  +R       R ++
Sbjct: 574 RSYSRRIKI-------ESNRARVKIRDR-RRSNRNSIERERRRNRSPSRERRRSRSRSRD 625

Query: 141 HSTNK 145
             TN+
Sbjct: 626 RRTNR 630


>gi|154146193 splicing factor, arginine/serine-rich 130 [Homo
           sapiens]
          Length = 805

 Score = 36.6 bits (83), Expect = 0.078
 Identities = 32/125 (25%), Positives = 54/125 (43%), Gaps = 13/125 (10%)

Query: 21  SINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQ 80
           S N R  S  S+ SSS+      SS +S+ SSS    KR S  R+P+I     K    + 
Sbjct: 519 SSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTI-----KARRSRS 573

Query: 81  EPTNQNLSISNGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKE 140
              ++ + I        SN  ++ + +  +   R+S+     RN+  +R       R ++
Sbjct: 574 RSYSRRIKI-------ESNRARVKIRDR-RRSNRNSIERERRRNRSPSRERRRSRSRSRD 625

Query: 141 HSTNK 145
             TN+
Sbjct: 626 RRTNR 630


>gi|239743291 PREDICTED: mucin 3A, intestinal [Homo sapiens]
          Length = 1486

 Score = 36.2 bits (82), Expect = 0.10
 Identities = 69/349 (19%), Positives = 119/349 (34%), Gaps = 42/349 (12%)

Query: 9   STLVSRLPI-FRRSINRRHDSLPSSPSS----SNTVGVHSSSPSSTNSSSGS-------- 55
           STLV+ LP    RS      + P+SP+S    S T   +S+S + T S+  S        
Sbjct: 315 STLVTTLPTTISRSTPTSETTYPTSPTSTVTDSTTKIAYSTSMTGTLSTETSLPPTSSSL 374

Query: 56  ---------------TGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSISNGAQPGHSNM 100
                          T    S   TPS S      +           SI+    P HS  
Sbjct: 375 PTTETATTPMTNLVTTTTEISSHSTPSFSSSTIYSTVTSHSTPRFTSSITTTETPSHSTP 434

Query: 101 QKLSLEEHIKTRGRHSVGFSS-----SRNKKITRSLTEDFEREKEHSTNKNVFINCLSSG 155
           +  S   + KT    S  F+S           T S T      +  S +   F + +++ 
Sbjct: 435 RFTSSFTNTKTTSHRSPSFTSLITTTETTSHSTPSFTSSITTTETTSHSARSFTSSITTT 494

Query: 156 KSEGDD-----SGFTEDQTR-RSVKQSTRKLLPKSFSSHYKFSKPVLQSQSISLVQQSEF 209
           ++   +     S  T  +T   S    T  +     +SH   S P   S   +       
Sbjct: 495 ETTSHNTRSFTSSITTTETNSHSTTSFTSSITTTETTSH---STPSFSSSITTTETPLHS 551

Query: 210 SLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVS 269
           +  +T +          +P  +  +T    +S  +P  ++ +TT +T SE       S  
Sbjct: 552 TPGLTSWVTTTKTTSHITPGLTSSITTTETTSHSTPGFTSSITTTETTSESTPSLSSSTI 611

Query: 270 EMDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAI 318
                + + ++ SH        + + ++ +S +    TT L    P ++
Sbjct: 612 YSTVSTSTTAITSHFTTSETAVTPTPVTPSSLSTDIPTTSLRTLTPSSV 660


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.124    0.341 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,106,952
Number of Sequences: 37866
Number of extensions: 1223216
Number of successful extensions: 5625
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 159
Number of HSP's that attempted gapping in prelim test: 4922
Number of HSP's gapped (non-prelim): 629
length of query: 677
length of database: 18,247,518
effective HSP length: 109
effective length of query: 568
effective length of database: 14,120,124
effective search space: 8020230432
effective search space used: 8020230432
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.