Guide to the Human Genome
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Search of human proteins with 46399198

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46399198 testis-specific bromodomain protein [Homo sapiens]
         (947 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46399200 testis-specific bromodomain protein [Homo sapiens]       1876   0.0  
gi|46399198 testis-specific bromodomain protein [Homo sapiens]       1876   0.0  
gi|164419758 bromodomain containing 2 [Homo sapiens]                  654   0.0  
gi|4826806 bromodomain containing 2 [Homo sapiens]                    654   0.0  
gi|11067749 bromodomain containing protein 3 [Homo sapiens]           647   0.0  
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ...   595   e-170
gi|7657218 bromodomain-containing protein 4 isoform short [Homo ...   586   e-167
gi|93102371 polybromo 1 isoform 2 [Homo sapiens]                       94   8e-19
gi|41281917 polybromo 1 isoform 4 [Homo sapiens]                       94   8e-19
gi|38788260 bromodomain PHD finger transcription factor isoform ...    84   6e-16
gi|38788274 bromodomain PHD finger transcription factor isoform ...    84   6e-16
gi|40805843 K(lysine) acetyltransferase 2B [Homo sapiens]              80   1e-14
gi|50345997 E1A binding protein p300 [Homo sapiens]                    77   8e-14
gi|119943102 CREB binding protein isoform b [Homo sapiens]             77   8e-14
gi|119943104 CREB binding protein isoform a [Homo sapiens]             77   8e-14
gi|47419911 transcriptional intermediary factor 1 alpha isoform ...    77   8e-14
gi|47419909 transcriptional intermediary factor 1 alpha isoform ...    77   8e-14
gi|153791535 general control of amino acid synthesis 5-like 2 [H...    75   2e-13
gi|148612882 cat eye syndrome chromosome region, candidate 2 [Ho...    74   8e-13
gi|32967605 bromodomain adjacent to zinc finger domain, 1A isofo...    73   1e-12
gi|32967603 bromodomain adjacent to zinc finger domain, 1A isofo...    73   1e-12
gi|94681063 bromodomain adjacent to zinc finger domain, 2B [Homo...    73   1e-12
gi|34996489 pleckstrin homology domain interacting protein [Homo...    67   8e-11
gi|74027251 tripartite motif-containing 33 protein isoform beta ...    65   4e-10
gi|20357588 TBP-associated factor 1 isoform 2 [Homo sapiens]           65   4e-10
gi|20357585 TBP-associated factor 1 isoform 1 [Homo sapiens]           65   4e-10
gi|91176325 bromodomain adjacent to zinc finger domain, 2A [Homo...    64   5e-10
gi|30794372 polybromo 1 isoform 1 [Homo sapiens]                       64   7e-10
gi|209977097 tripartite motif-containing 66 [Homo sapiens]             64   9e-10
gi|24429572 TBP-associated factor RNA polymerase 1-like [Homo sa...    63   1e-09

>gi|46399200 testis-specific bromodomain protein [Homo sapiens]
          Length = 947

 Score = 1876 bits (4859), Expect = 0.0
 Identities = 947/947 (100%), Positives = 947/947 (100%)

Query: 1   MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVK 60
           MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVK
Sbjct: 1   MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVK 60

Query: 61  LQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQ 120
           LQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQ
Sbjct: 61  LQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQ 120

Query: 121 ALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSV 180
           ALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSV
Sbjct: 121 ALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSV 180

Query: 181 FPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSV 240
           FPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSV
Sbjct: 181 FPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSV 240

Query: 241 ALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVD 300
           ALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVD
Sbjct: 241 ALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVD 300

Query: 301 VNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVT 360
           VNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVT
Sbjct: 301 VNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVT 360

Query: 361 MARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERV 420
           MARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERV
Sbjct: 361 MARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERV 420

Query: 421 KRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRL 480
           KRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRL
Sbjct: 421 KRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRL 480

Query: 481 KEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSR 540
           KEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSR
Sbjct: 481 KEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSR 540

Query: 541 EPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQ 600
           EPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQ
Sbjct: 541 EPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQ 600

Query: 601 ELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSS 660
           ELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSS
Sbjct: 601 ELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSS 660

Query: 661 DSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECILPEGRTGVTQIGYCVQDTTSANTTL 720
           DSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECILPEGRTGVTQIGYCVQDTTSANTTL
Sbjct: 661 DSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECILPEGRTGVTQIGYCVQDTTSANTTL 720

Query: 721 VHQTTPSHVMPPNHHQLAFNYQELEHLQTVKNISPLQILPPSGDSEQLSNGITVMHPSGD 780
           VHQTTPSHVMPPNHHQLAFNYQELEHLQTVKNISPLQILPPSGDSEQLSNGITVMHPSGD
Sbjct: 721 VHQTTPSHVMPPNHHQLAFNYQELEHLQTVKNISPLQILPPSGDSEQLSNGITVMHPSGD 780

Query: 781 SDTTMLESECQAPVQKDIKIKNADSWKSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKA 840
           SDTTMLESECQAPVQKDIKIKNADSWKSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKA
Sbjct: 781 SDTTMLESECQAPVQKDIKIKNADSWKSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKA 840

Query: 841 RTQELIRKHLEQNTKELKASQENQRDLGNGLTVESFSNKIQNKCSGEEQKEHQQSSEAQD 900
           RTQELIRKHLEQNTKELKASQENQRDLGNGLTVESFSNKIQNKCSGEEQKEHQQSSEAQD
Sbjct: 841 RTQELIRKHLEQNTKELKASQENQRDLGNGLTVESFSNKIQNKCSGEEQKEHQQSSEAQD 900

Query: 901 KSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD 947
           KSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD
Sbjct: 901 KSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD 947


>gi|46399198 testis-specific bromodomain protein [Homo sapiens]
          Length = 947

 Score = 1876 bits (4859), Expect = 0.0
 Identities = 947/947 (100%), Positives = 947/947 (100%)

Query: 1   MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVK 60
           MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVK
Sbjct: 1   MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVK 60

Query: 61  LQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQ 120
           LQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQ
Sbjct: 61  LQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQ 120

Query: 121 ALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSV 180
           ALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSV
Sbjct: 121 ALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSV 180

Query: 181 FPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSV 240
           FPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSV
Sbjct: 181 FPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSV 240

Query: 241 ALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVD 300
           ALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVD
Sbjct: 241 ALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVD 300

Query: 301 VNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVT 360
           VNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVT
Sbjct: 301 VNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVT 360

Query: 361 MARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERV 420
           MARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERV
Sbjct: 361 MARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERV 420

Query: 421 KRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRL 480
           KRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRL
Sbjct: 421 KRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRL 480

Query: 481 KEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSR 540
           KEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSR
Sbjct: 481 KEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSR 540

Query: 541 EPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQ 600
           EPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQ
Sbjct: 541 EPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQ 600

Query: 601 ELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSS 660
           ELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSS
Sbjct: 601 ELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSS 660

Query: 661 DSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECILPEGRTGVTQIGYCVQDTTSANTTL 720
           DSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECILPEGRTGVTQIGYCVQDTTSANTTL
Sbjct: 661 DSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECILPEGRTGVTQIGYCVQDTTSANTTL 720

Query: 721 VHQTTPSHVMPPNHHQLAFNYQELEHLQTVKNISPLQILPPSGDSEQLSNGITVMHPSGD 780
           VHQTTPSHVMPPNHHQLAFNYQELEHLQTVKNISPLQILPPSGDSEQLSNGITVMHPSGD
Sbjct: 721 VHQTTPSHVMPPNHHQLAFNYQELEHLQTVKNISPLQILPPSGDSEQLSNGITVMHPSGD 780

Query: 781 SDTTMLESECQAPVQKDIKIKNADSWKSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKA 840
           SDTTMLESECQAPVQKDIKIKNADSWKSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKA
Sbjct: 781 SDTTMLESECQAPVQKDIKIKNADSWKSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKA 840

Query: 841 RTQELIRKHLEQNTKELKASQENQRDLGNGLTVESFSNKIQNKCSGEEQKEHQQSSEAQD 900
           RTQELIRKHLEQNTKELKASQENQRDLGNGLTVESFSNKIQNKCSGEEQKEHQQSSEAQD
Sbjct: 841 RTQELIRKHLEQNTKELKASQENQRDLGNGLTVESFSNKIQNKCSGEEQKEHQQSSEAQD 900

Query: 901 KSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD 947
           KSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD
Sbjct: 901 KSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD 947


>gi|164419758 bromodomain containing 2 [Homo sapiens]
          Length = 801

 Score =  654 bits (1686), Expect = 0.0
 Identities = 384/745 (51%), Positives = 488/745 (65%), Gaps = 94/745 (12%)

Query: 13  NPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKN 72
           NPPPPE  N KK GR+TNQLQYL KVV+K LWKH F+WPF++PVDAVKL LPDY+ IIK 
Sbjct: 60  NPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQ 119

Query: 73  PMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQ 132
           PMD+ TIK+RLEN YY  ASEC++DFNTMF+NCY+YNKP DDIVLMAQ LEK+F+QK++ 
Sbjct: 120 PMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVAS 179

Query: 133 MPQEEQVVGV---KERIKKGTQQNI---AVSSAKEK---SSPSATEKVFKQQEIPSVF-- 181
           MPQEEQ + V   K   KKG +      +V+SA +    SS S T       EIP+    
Sbjct: 180 MPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLN 239

Query: 182 ---PKTSISPL-NVVQGASVNSSSQTAAQVT------KGVKRKADTTTPATSAVKA-SSE 230
              P    SPL   +  A     + TAA         KGVKRKADTTTP  +A+ A  S 
Sbjct: 240 IPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSP 299

Query: 231 FSP--TFTEKSVALPPIKENM------PKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKE 282
            SP  +   K+  LPP++         P+  LPDSQQQ+   K  K++EQL+HC+ ILKE
Sbjct: 300 ASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKE 359

Query: 283 MLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVR 342
           +L+KKH +YAWPFY PVD +ALGLH+Y+D++K+PMDL T+K KM+N++Y+DA +FAADVR
Sbjct: 360 LLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVR 419

Query: 343 LMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCY-------IKTDITE 395
           LMF NCYKYNPPDH+VV MAR LQDVFE  ++K+P EP+E  PL         +    +E
Sbjct: 420 LMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSE 479

Query: 396 TTGRENTNEASSEG-------------NSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQ 442
           ++  E+++E+SSE              + S DSE+ER  RLA+LQEQL+AVH+QL  LSQ
Sbjct: 480 SSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQ 539

Query: 443 VPFRKLNKKKEKSKKEKKKEK--------VNNSNENPRKMCEQMRLKEK----------- 483
            P  K  +K+EK +K+KK++          +  ++ PR        K K           
Sbjct: 540 GPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAA 599

Query: 484 -----------SKRNQPKKRKQQF-----IGLKSEDEDNAKPMNYDEKRQLSLNINKLPG 527
                      S    PKK  +        G  SE+E+ ++PM+YDEKRQLSL+INKLPG
Sbjct: 600 LGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPG 659

Query: 528 DKLGRVVHIIQSREPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPA--K 585
           +KLGRVVHIIQ+REPSL +SNP+EIEIDFETLK STLRELE+YV +CLRK+P KP    K
Sbjct: 660 EKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKK 719

Query: 586 KIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTK--SDKTQPSKAVE-NVSRLSESSS 642
            +  +KEEL  +KK+ELEKRL DV+ QLNS K+  K  ++KT+ S A +  VSRLS SSS
Sbjct: 720 PVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSS 779

Query: 643 SSSSSSESESSSSDLSSSDSSDSES 667
           SS SSS S SS    SSSD+SDS+S
Sbjct: 780 SSDSSSSSSSS----SSSDTSDSDS 800



 Score = 31.2 bits (69), Expect = 4.8
 Identities = 16/46 (34%), Positives = 23/46 (50%)

Query: 632 ENVSRLSESSSSSSSSSESESSSSDLSSSDSSDSESEMFPKFTEVK 677
           E+ S  S S SSS    E +    +   S+SSDSE E   +  E++
Sbjct: 479 ESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQ 524


>gi|4826806 bromodomain containing 2 [Homo sapiens]
          Length = 801

 Score =  654 bits (1686), Expect = 0.0
 Identities = 384/745 (51%), Positives = 488/745 (65%), Gaps = 94/745 (12%)

Query: 13  NPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKN 72
           NPPPPE  N KK GR+TNQLQYL KVV+K LWKH F+WPF++PVDAVKL LPDY+ IIK 
Sbjct: 60  NPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQ 119

Query: 73  PMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQ 132
           PMD+ TIK+RLEN YY  ASEC++DFNTMF+NCY+YNKP DDIVLMAQ LEK+F+QK++ 
Sbjct: 120 PMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVAS 179

Query: 133 MPQEEQVVGV---KERIKKGTQQNI---AVSSAKEK---SSPSATEKVFKQQEIPSVF-- 181
           MPQEEQ + V   K   KKG +      +V+SA +    SS S T       EIP+    
Sbjct: 180 MPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLN 239

Query: 182 ---PKTSISPL-NVVQGASVNSSSQTAAQVT------KGVKRKADTTTPATSAVKA-SSE 230
              P    SPL   +  A     + TAA         KGVKRKADTTTP  +A+ A  S 
Sbjct: 240 IPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSP 299

Query: 231 FSP--TFTEKSVALPPIKENM------PKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKE 282
            SP  +   K+  LPP++         P+  LPDSQQQ+   K  K++EQL+HC+ ILKE
Sbjct: 300 ASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKE 359

Query: 283 MLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVR 342
           +L+KKH +YAWPFY PVD +ALGLH+Y+D++K+PMDL T+K KM+N++Y+DA +FAADVR
Sbjct: 360 LLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVR 419

Query: 343 LMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCY-------IKTDITE 395
           LMF NCYKYNPPDH+VV MAR LQDVFE  ++K+P EP+E  PL         +    +E
Sbjct: 420 LMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSE 479

Query: 396 TTGRENTNEASSEG-------------NSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQ 442
           ++  E+++E+SSE              + S DSE+ER  RLA+LQEQL+AVH+QL  LSQ
Sbjct: 480 SSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQ 539

Query: 443 VPFRKLNKKKEKSKKEKKKEK--------VNNSNENPRKMCEQMRLKEK----------- 483
            P  K  +K+EK +K+KK++          +  ++ PR        K K           
Sbjct: 540 GPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAA 599

Query: 484 -----------SKRNQPKKRKQQF-----IGLKSEDEDNAKPMNYDEKRQLSLNINKLPG 527
                      S    PKK  +        G  SE+E+ ++PM+YDEKRQLSL+INKLPG
Sbjct: 600 LGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPG 659

Query: 528 DKLGRVVHIIQSREPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPA--K 585
           +KLGRVVHIIQ+REPSL +SNP+EIEIDFETLK STLRELE+YV +CLRK+P KP    K
Sbjct: 660 EKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKK 719

Query: 586 KIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTK--SDKTQPSKAVE-NVSRLSESSS 642
            +  +KEEL  +KK+ELEKRL DV+ QLNS K+  K  ++KT+ S A +  VSRLS SSS
Sbjct: 720 PVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSS 779

Query: 643 SSSSSSESESSSSDLSSSDSSDSES 667
           SS SSS S SS    SSSD+SDS+S
Sbjct: 780 SSDSSSSSSSS----SSSDTSDSDS 800



 Score = 31.2 bits (69), Expect = 4.8
 Identities = 16/46 (34%), Positives = 23/46 (50%)

Query: 632 ENVSRLSESSSSSSSSSESESSSSDLSSSDSSDSESEMFPKFTEVK 677
           E+ S  S S SSS    E +    +   S+SSDSE E   +  E++
Sbjct: 479 ESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQ 524


>gi|11067749 bromodomain containing protein 3 [Homo sapiens]
          Length = 726

 Score =  647 bits (1668), Expect = 0.0
 Identities = 371/716 (51%), Positives = 458/716 (63%), Gaps = 69/716 (9%)

Query: 12  VNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIK 71
           VNPPPPE  N  K GR TNQLQY+Q VV+K LWKH F+WPF +PVDA+KL LPDY+ IIK
Sbjct: 19  VNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIK 78

Query: 72  NPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLS 131
           NPMD+ TIKKRLEN YY  ASEC++DFNTMF+NCY+YNKP DDIVLMAQALEK+F+QK++
Sbjct: 79  NPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVA 138

Query: 132 QMPQEEQVV---GVKERIKK--------GTQQNIAVSSAKEKSSPSATEKVFKQQEIPSV 180
           QMPQEE  +     K + +K        GTQQ  AVSS    +   +      Q  + + 
Sbjct: 139 QMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPATPFQSVPPTVSQTPVIAA 198

Query: 181 FP----KTSISPLNVVQGASVNSSSQTAAQVT---------KGVKRKADTTTPATSAVKA 227
            P      +++ + V   A+    +     V          KGVKRKADTTTP TSA+ A
Sbjct: 199 TPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITA 258

Query: 228 S-SEFSPTFTEKSVAL---------PPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCS 277
           S SE  P  ++   A           PIK   PK  L D +   +  K  K++E LR+C 
Sbjct: 259 SRSESPPPLSDPKQAKVVARRESGGRPIKP--PKKDLEDGEVPQHAGKKGKLSEHLRYCD 316

Query: 278 EILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKF 337
            IL+EML+KKH +YAWPFY PVD  AL LH+Y+D++K+PMDL T+K KMD +EY DA  F
Sbjct: 317 SILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGF 376

Query: 338 AADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPL-CYIKTDITET 396
           AADVRLMF NCYKYNPPDHEVV MAR LQDVFE  F+K+P EPVE+  L       +++ 
Sbjct: 377 AADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAAPMVSKG 436

Query: 397 TGRENTNEASSEGNSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSK 456
                ++E SS  + S DSE+ER  RLA+LQEQLKAVH+QL  LSQ P  K  KKKEK +
Sbjct: 437 AESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKE 496

Query: 457 KEKKKEKVNNSNENPRKMCEQMR-------LKEKSKRNQPKKR---------------KQ 494
           KEKKK+      E  +   E+ +        K+  ++  P K+               KQ
Sbjct: 497 KEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKANSTTTAGRQLKKGGKQ 556

Query: 495 QFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPSLSNSNPDEIEI 554
                 SE+E+   PM+YDEKRQLSL+IN+LPG+KLGRVVHIIQSREPSL +SNPDEIEI
Sbjct: 557 ASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEI 616

Query: 555 DFETLKASTLRELEKYVSACLRKRPLKP----PAKKIMMSKEELHSQKKQELEKRLLDVN 610
           DFETLK +TLRELE+YV +CL+K+  KP      K+   SKEEL  +KK+ELEKRL DV+
Sbjct: 617 DFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKKELEKRLQDVS 676

Query: 611 NQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSSDSSDSE 666
            QL+S K+  + +K  P  A         S  SSSSSSES SSSS  SSSDSSDSE
Sbjct: 677 GQLSSSKKPARKEK--PGSAPSG----GPSRLSSSSSSESGSSSSSGSSSDSSDSE 726


>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
           sapiens]
          Length = 1362

 Score =  595 bits (1533), Expect = e-170
 Identities = 360/763 (47%), Positives = 446/763 (58%), Gaps = 138/763 (18%)

Query: 4   PSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQL 63
           P    A   NPPPPE  N  K  R TNQLQYL +VVLK LWKH F+WPFQ+PVDAVKL L
Sbjct: 35  PQPANAASTNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNL 94

Query: 64  PDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALE 123
           PDYY IIK PMD+ TIKKRLEN YY  A ECI+DFNTMF+NCY+YNKPGDDIVLMA+ALE
Sbjct: 95  PDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALE 154

Query: 124 KLFMQKLSQMPQEEQVVGVKE-------RIKKGT-----------------------QQN 153
           KLF+QK++++P EE  + + +       R + GT                       Q N
Sbjct: 155 KLFLQKINELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPN 214

Query: 154 IAVSSAKEKSSPSATEKVFKQQEIPSVFPKTSI----------------SPLNVVQGASV 197
                A     P+ T  +  Q  + +V P   +                +P  V     +
Sbjct: 215 PPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPI 274

Query: 198 NSSSQTAAQVTKGVKRKADTTTPAT-SAVKASSEFSPT-----FTEKSVALPPIKENMPK 251
            +++    +  KGVKRKADTTTP T   +       P        ++  +  P+K   PK
Sbjct: 275 IAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKP--PK 332

Query: 252 NVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYD 311
             +PDSQQ     K+ KV+EQL+ CS ILKEM AKKH +YAWPFY PVDV ALGLH+Y D
Sbjct: 333 KDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCD 392

Query: 312 VVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFET 371
           ++K+PMD+ TIK K++ +EY+DA +F ADVRLMF NCYKYNPPDHEVV MAR LQDVFE 
Sbjct: 393 IIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEM 452

Query: 372 HFSKIPIEPVE-----SMPLCYIKTD-ITETTGRENTNEASSEGNSS-DDSEDERVKRLA 424
            F+K+P EP E     S P     T  +   +  ++++++SS+ +SS DDSE+ER +RLA
Sbjct: 453 RFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLA 512

Query: 425 KLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRLKEKS 484
           +LQEQLKAVH+QL  LSQ P +   KKKEK KKEKKKEK      + RK   +   K K+
Sbjct: 513 ELQEQLKAVHEQLAALSQ-PQQNKPKKKEKDKKEKKKEK------HKRKEEVEENKKSKA 565

Query: 485 KRNQPKKRKQQFIG-------------------LKSEDEDNAKPMNYDEKRQLSLNINKL 525
           K   PKK K+                        +SE+ED  KPM+Y+EKRQLSL+INKL
Sbjct: 566 KEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKL 625

Query: 526 PGDKLGRVVHIIQSREPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAK 585
           PG+KLGRVVHIIQSREPSL NSNPDEIEIDFETLK STLRELE+YV++CLRK+  KP A+
Sbjct: 626 PGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKK-RKPQAE 684

Query: 586 KIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSS 645
           K+                    DV                           ++ SS    
Sbjct: 685 KV--------------------DV---------------------------IAGSSKMKG 697

Query: 646 SSSESESSSSDLSSSDSSDSESEMFPKFTEVKPNDSPSKENVK 688
            SS    SSS+ SSSDS DSE+EM PK    K    P +E  K
Sbjct: 698 FSSSESESSSESSSSDSEDSETEMAPK---SKKKGHPGREQKK 737



 Score =  104 bits (259), Expect = 4e-22
 Identities = 68/190 (35%), Positives = 101/190 (53%), Gaps = 21/190 (11%)

Query: 777  PSGDSDTTMLESECQAPV--QKDIKIKNADSWKSLGK--PVKPSGVMKSSDELFNQFRKA 832
            P G  D    + E + PV  +KD+KIKN  SW SL +  P  PS   KSS + F QFR+A
Sbjct: 1171 PPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSFEQFRRA 1230

Query: 833  AIEKEVKARTQELIRKHLEQNTKELKASQENQRDLGNGLTV------ESFSNKIQNKCSG 886
            A EKE + +  +   +H E+  + L+  +   R+  + L        E+   + Q +   
Sbjct: 1231 AREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQR 1290

Query: 887  EEQKEHQQSSEA-----------QDKSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQ 935
            +EQ++ QQ   A             + +  L + R+LAR++EQERRRREAM  TIDM  Q
Sbjct: 1291 QEQQQQQQQQAAAVAAAATPQAQSSQPQSMLDQQRELARKREQERRRREAMAATIDMNFQ 1350

Query: 936  SDIMTMFENN 945
            SD++++FE N
Sbjct: 1351 SDLLSIFEEN 1360


>gi|7657218 bromodomain-containing protein 4 isoform short [Homo
           sapiens]
          Length = 722

 Score =  586 bits (1510), Expect = e-167
 Identities = 352/742 (47%), Positives = 437/742 (58%), Gaps = 135/742 (18%)

Query: 4   PSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQL 63
           P    A   NPPPPE  N  K  R TNQLQYL +VVLK LWKH F+WPFQ+PVDAVKL L
Sbjct: 35  PQPANAASTNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNL 94

Query: 64  PDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALE 123
           PDYY IIK PMD+ TIKKRLEN YY  A ECI+DFNTMF+NCY+YNKPGDDIVLMA+ALE
Sbjct: 95  PDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALE 154

Query: 124 KLFMQKLSQMPQEEQVVGVKE-------RIKKGT-----------------------QQN 153
           KLF+QK++++P EE  + + +       R + GT                       Q N
Sbjct: 155 KLFLQKINELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPN 214

Query: 154 IAVSSAKEKSSPSATEKVFKQQEIPSVFPKTSI----------------SPLNVVQGASV 197
                A     P+ T  +  Q  + +V P   +                +P  V     +
Sbjct: 215 PPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPI 274

Query: 198 NSSSQTAAQVTKGVKRKADTTTPAT-SAVKASSEFSPT-----FTEKSVALPPIKENMPK 251
            +++    +  KGVKRKADTTTP T   +       P        ++  +  P+K   PK
Sbjct: 275 IAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKP--PK 332

Query: 252 NVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYD 311
             +PDSQQ     K+ KV+EQL+ CS ILKEM AKKH +YAWPFY PVDV ALGLH+Y D
Sbjct: 333 KDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCD 392

Query: 312 VVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFET 371
           ++K+PMD+ TIK K++ +EY+DA +F ADVRLMF NCYKYNPPDHEVV MAR LQDVFE 
Sbjct: 393 IIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEM 452

Query: 372 HFSKIPIEPVE-----SMPLCYIKTD-ITETTGRENTNEASSEGNSS-DDSEDERVKRLA 424
            F+K+P EP E     S P     T  +   +  ++++++SS+ +SS DDSE+ER +RLA
Sbjct: 453 RFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLA 512

Query: 425 KLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRLKEKS 484
           +LQEQLKAVH+QL  LSQ P +   KKKEK KKEKKKEK      + RK   +   K K+
Sbjct: 513 ELQEQLKAVHEQLAALSQ-PQQNKPKKKEKDKKEKKKEK------HKRKEEVEENKKSKA 565

Query: 485 KRNQPKKRKQQFIG-------------------LKSEDEDNAKPMNYDEKRQLSLNINKL 525
           K   PKK K+                        +SE+ED  KPM+Y+EKRQLSL+INKL
Sbjct: 566 KEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKL 625

Query: 526 PGDKLGRVVHIIQSREPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAK 585
           PG+KLGRVVHIIQSREPSL NSNPDEIEIDFETLK STLRELE+YV++CLRK+  KP A+
Sbjct: 626 PGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKK-RKPQAE 684

Query: 586 KIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSS 645
           K+                    DV                           ++ SS    
Sbjct: 685 KV--------------------DV---------------------------IAGSSKMKG 697

Query: 646 SSSESESSSSDLSSSDSSDSES 667
            SS    SSS+ SSSDS DSE+
Sbjct: 698 FSSSESESSSESSSSDSEDSET 719


>gi|93102371 polybromo 1 isoform 2 [Homo sapiens]
          Length = 1582

 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 77/311 (24%), Positives = 130/311 (41%), Gaps = 43/311 (13%)

Query: 60  KLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMA 119
           K+Q PDYY IIK P+DL TI +R++N  Y       +D + +  N   YN+PG  +   A
Sbjct: 214 KVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDA 273

Query: 120 QALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPS 179
            +++K+F  K +++   E     K  ++  T  N+A   A   + PS ++    ++  P+
Sbjct: 274 NSIKKIFYMKKAEIEHHEM---AKSSLRMRTPSNLA---AARLTGPSHSKGSLGEERNPT 327

Query: 180 VFPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKS 239
                       VQG  +++ +     +  G + + D    A    +  SE     +   
Sbjct: 328 ---SKYYRNKRAVQGGRLSAITMA---LQYGSESEEDAALAAARYEEGESEAESITSFMD 381

Query: 240 VALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPV 299
           V+ P               Q Y+ V         R C     +++A+       PFY+  
Sbjct: 382 VSNP-------------FYQLYDTV---------RSCRNNQGQLIAE-------PFYHLP 412

Query: 300 DVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVV 359
                   +YY  +K P+ L  I+ K+ NQEY+       D+ LMF N  +YN P+  + 
Sbjct: 413 SKKK--YPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIY 470

Query: 360 TMARMLQDVFE 370
                LQ V +
Sbjct: 471 KRVLKLQQVMQ 481



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 75/349 (21%), Positives = 129/349 (36%), Gaps = 47/349 (13%)

Query: 60  KLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMA 119
           K + PDYY  IK P+ L  I+ +L+N+ Y        D N MF N   YN P   I    
Sbjct: 414 KKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRV 473

Query: 120 QALEKLFMQKLSQMPQEEQVVGVKERI----------KKGTQQNI----------AVSSA 159
             L+++   K  ++ + + +      I          K+ +++NI           V  A
Sbjct: 474 LKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEA 533

Query: 160 KEKSSPSATEKVFKQQEIPSVFP---KTSISP--LNVVQGASVNSSSQTAAQVTKGVK-- 212
           +E  S      +F  +     +P   K  + P  L +++    N        + + +K  
Sbjct: 534 REPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLM 593

Query: 213 -RKADTTTPATSAV------------KASSEFSPTFTEKSVALPPIKENMPKNVLPDSQQ 259
            R A       S V            +   E  P   +  +A P +K +    + P   +
Sbjct: 594 FRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSK 653

Query: 260 QYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDL 319
               ++     ++L    E +K    K+    +  F      + L   +YY  +K PMD+
Sbjct: 654 YMTPMQ-----QKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELP--DYYLTIKKPMDM 706

Query: 320 GTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDV 368
             I+  M   +Y+D      D  +MF N   YN P+  +   A +L  V
Sbjct: 707 EKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKV 755



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 26/76 (34%), Positives = 38/76 (50%)

Query: 62  QLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQA 121
           +LPDYY  IK PMD+  I+  +    Y      +EDF  MF+N   YN+P   I   A  
Sbjct: 692 ELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALV 751

Query: 122 LEKLFMQKLSQMPQEE 137
           L K+ ++    +  +E
Sbjct: 752 LHKVLLETRRDLEGDE 767



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 67/330 (20%), Positives = 133/330 (40%), Gaps = 36/330 (10%)

Query: 308 NYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQD 367
           +YY ++K P+DL TI +++ N  YK  +  A D+ L+  N   YN P  +V   A  ++ 
Sbjct: 219 DYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANSIKK 278

Query: 368 VFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDD----SEDERVKRL 423
           +F  +  K  IE  E           +       T  + S+G+  ++    S+  R KR 
Sbjct: 279 IF--YMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKR- 335

Query: 424 AKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRLKEK 483
           A    +L A+   LQ  S+             + E + E + +  +      +       
Sbjct: 336 AVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFYQLYDTVRS 395

Query: 484 SKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPS 543
            + NQ +   + F  L S+     K  +Y ++ ++ +++ +            I+++  +
Sbjct: 396 CRNNQGQLIAEPFYHLPSK----KKYPDYYQQIKMPISLQQ------------IRTKLKN 439

Query: 544 LSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQELE 603
                 D +E D   +  +  R      ++ + KR LK          +++   KK+EL 
Sbjct: 440 QEYETLDHLECDLNLMFENAKR--YNVPNSAIYKRVLK---------LQQVMQAKKKELA 488

Query: 604 KR--LLDVNNQLNSRKRQTKSDKTQPSKAV 631
           +R  + D ++ ++S    T S K +  K +
Sbjct: 489 RRDDIEDGDSMISSATSDTGSAKRKSKKNI 518



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 23/62 (37%), Positives = 34/62 (54%)

Query: 308 NYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQD 367
           +YY+VV  P+DL  I++K+  +EY D     AD +L+F N   Y  PD      A  L D
Sbjct: 83  DYYEVVSQPIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWD 142

Query: 368 VF 369
           ++
Sbjct: 143 LY 144



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 29/111 (26%), Positives = 54/111 (48%), Gaps = 4/111 (3%)

Query: 64  PDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALE 123
           PDYY ++  P+DL  I+++L+ + Y   +    DF  +F+N   Y KP       A  L 
Sbjct: 82  PDYYEVVSQPIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLW 141

Query: 124 KLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQ 174
            L+++  ++  Q+ +     E   +  Q N    +  E SSP+  +++ +Q
Sbjct: 142 DLYLRTRNEFVQKGE--ADDEDDDEDGQDN--QGTVTEGSSPAYLKEILEQ 188



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 37/186 (19%), Positives = 74/186 (39%), Gaps = 3/186 (1%)

Query: 308 NYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQD 367
           +YY ++  PMDL  I+  + N +Y        D++LMF N   YN    +V   A +L+ 
Sbjct: 557 DYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEK 616

Query: 368 VFETHFSKI-PIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERVKRLAKL 426
           + +    ++ P+   + M    +K         + +   +      ++  +       K 
Sbjct: 617 LLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKR 676

Query: 427 QEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQ--MRLKEKS 484
             +L A+  +L   S++P   L  KK    ++ +   + N  ++   M E   M      
Sbjct: 677 GRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNAC 736

Query: 485 KRNQPK 490
             N+P+
Sbjct: 737 TYNEPE 742


>gi|41281917 polybromo 1 isoform 4 [Homo sapiens]
          Length = 1582

 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 77/311 (24%), Positives = 130/311 (41%), Gaps = 43/311 (13%)

Query: 60  KLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMA 119
           K+Q PDYY IIK P+DL TI +R++N  Y       +D + +  N   YN+PG  +   A
Sbjct: 214 KVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDA 273

Query: 120 QALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPS 179
            +++K+F  K +++   E     K  ++  T  N+A   A   + PS ++    ++  P+
Sbjct: 274 NSIKKIFYMKKAEIEHHEM---AKSSLRMRTPSNLA---AARLTGPSHSKGSLGEERNPT 327

Query: 180 VFPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKS 239
                       VQG  +++ +     +  G + + D    A    +  SE     +   
Sbjct: 328 ---SKYYRNKRAVQGGRLSAITMA---LQYGSESEEDAALAAARYEEGESEAESITSFMD 381

Query: 240 VALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPV 299
           V+ P               Q Y+ V         R C     +++A+       PFY+  
Sbjct: 382 VSNP-------------FYQLYDTV---------RSCRNNQGQLIAE-------PFYHLP 412

Query: 300 DVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVV 359
                   +YY  +K P+ L  I+ K+ NQEY+       D+ LMF N  +YN P+  + 
Sbjct: 413 SKKK--YPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIY 470

Query: 360 TMARMLQDVFE 370
                LQ V +
Sbjct: 471 KRVLKLQQVMQ 481



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 75/349 (21%), Positives = 129/349 (36%), Gaps = 47/349 (13%)

Query: 60  KLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMA 119
           K + PDYY  IK P+ L  I+ +L+N+ Y        D N MF N   YN P   I    
Sbjct: 414 KKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRV 473

Query: 120 QALEKLFMQKLSQMPQEEQVVGVKERI----------KKGTQQNI----------AVSSA 159
             L+++   K  ++ + + +      I          K+ +++NI           V  A
Sbjct: 474 LKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEA 533

Query: 160 KEKSSPSATEKVFKQQEIPSVFP---KTSISP--LNVVQGASVNSSSQTAAQVTKGVK-- 212
           +E  S      +F  +     +P   K  + P  L +++    N        + + +K  
Sbjct: 534 REPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLM 593

Query: 213 -RKADTTTPATSAV------------KASSEFSPTFTEKSVALPPIKENMPKNVLPDSQQ 259
            R A       S V            +   E  P   +  +A P +K +    + P   +
Sbjct: 594 FRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSK 653

Query: 260 QYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDL 319
               ++     ++L    E +K    K+    +  F      + L   +YY  +K PMD+
Sbjct: 654 YMTPMQ-----QKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELP--DYYLTIKKPMDM 706

Query: 320 GTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDV 368
             I+  M   +Y+D      D  +MF N   YN P+  +   A +L  V
Sbjct: 707 EKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKV 755



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 26/76 (34%), Positives = 38/76 (50%)

Query: 62  QLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQA 121
           +LPDYY  IK PMD+  I+  +    Y      +EDF  MF+N   YN+P   I   A  
Sbjct: 692 ELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALV 751

Query: 122 LEKLFMQKLSQMPQEE 137
           L K+ ++    +  +E
Sbjct: 752 LHKVLLETRRDLEGDE 767



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 67/330 (20%), Positives = 133/330 (40%), Gaps = 36/330 (10%)

Query: 308 NYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQD 367
           +YY ++K P+DL TI +++ N  YK  +  A D+ L+  N   YN P  +V   A  ++ 
Sbjct: 219 DYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANSIKK 278

Query: 368 VFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDD----SEDERVKRL 423
           +F  +  K  IE  E           +       T  + S+G+  ++    S+  R KR 
Sbjct: 279 IF--YMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKR- 335

Query: 424 AKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRLKEK 483
           A    +L A+   LQ  S+             + E + E + +  +      +       
Sbjct: 336 AVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFYQLYDTVRS 395

Query: 484 SKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPS 543
            + NQ +   + F  L S+     K  +Y ++ ++ +++ +            I+++  +
Sbjct: 396 CRNNQGQLIAEPFYHLPSK----KKYPDYYQQIKMPISLQQ------------IRTKLKN 439

Query: 544 LSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQELE 603
                 D +E D   +  +  R      ++ + KR LK          +++   KK+EL 
Sbjct: 440 QEYETLDHLECDLNLMFENAKR--YNVPNSAIYKRVLK---------LQQVMQAKKKELA 488

Query: 604 KR--LLDVNNQLNSRKRQTKSDKTQPSKAV 631
           +R  + D ++ ++S    T S K +  K +
Sbjct: 489 RRDDIEDGDSMISSATSDTGSAKRKSKKNI 518



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 23/62 (37%), Positives = 34/62 (54%)

Query: 308 NYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQD 367
           +YY+VV  P+DL  I++K+  +EY D     AD +L+F N   Y  PD      A  L D
Sbjct: 83  DYYEVVSQPIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWD 142

Query: 368 VF 369
           ++
Sbjct: 143 LY 144



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 29/111 (26%), Positives = 54/111 (48%), Gaps = 4/111 (3%)

Query: 64  PDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALE 123
           PDYY ++  P+DL  I+++L+ + Y   +    DF  +F+N   Y KP       A  L 
Sbjct: 82  PDYYEVVSQPIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLW 141

Query: 124 KLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQ 174
            L+++  ++  Q+ +     E   +  Q N    +  E SSP+  +++ +Q
Sbjct: 142 DLYLRTRNEFVQKGE--ADDEDDDEDGQDN--QGTVTEGSSPAYLKEILEQ 188



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 37/186 (19%), Positives = 74/186 (39%), Gaps = 3/186 (1%)

Query: 308 NYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQD 367
           +YY ++  PMDL  I+  + N +Y        D++LMF N   YN    +V   A +L+ 
Sbjct: 557 DYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEK 616

Query: 368 VFETHFSKI-PIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERVKRLAKL 426
           + +    ++ P+   + M    +K         + +   +      ++  +       K 
Sbjct: 617 LLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKR 676

Query: 427 QEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQ--MRLKEKS 484
             +L A+  +L   S++P   L  KK    ++ +   + N  ++   M E   M      
Sbjct: 677 GRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNAC 736

Query: 485 KRNQPK 490
             N+P+
Sbjct: 737 TYNEPE 742


>gi|38788260 bromodomain PHD finger transcription factor isoform 2
            [Homo sapiens]
          Length = 2903

 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 40/94 (42%), Positives = 54/94 (57%), Gaps = 2/94 (2%)

Query: 37   KVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIE 96
            K VL+ L  H  +WPF  PVD      PDYY +IK PMDL T+++R++ +YY K +E + 
Sbjct: 2794 KRVLRSLQAHKMAWPFLEPVDPN--DAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVA 2851

Query: 97   DFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKL 130
            D   +F NC  YN         A+ LE  F+QKL
Sbjct: 2852 DMTKIFDNCRYYNPSDSPFYQCAEVLESFFVQKL 2885



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 35/91 (38%), Positives = 51/91 (56%), Gaps = 5/91 (5%)

Query: 279  ILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFA 338
            +L+ + A K    AWPF  PVD N     +YY V+K PMDL T++E++  + Y+   +F 
Sbjct: 2796 VLRSLQAHK---MAWPFLEPVDPN--DAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFV 2850

Query: 339  ADVRLMFMNCYKYNPPDHEVVTMARMLQDVF 369
            AD+  +F NC  YNP D      A +L+  F
Sbjct: 2851 ADMTKIFDNCRYYNPSDSPFYQCAEVLESFF 2881



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 75/341 (21%), Positives = 134/341 (39%), Gaps = 61/341 (17%)

Query: 387  CYIKTDITETTGRENTNEASSEGNSSDDSED-ERVKRLAKLQEQLKAVHQQLQVLSQVPF 445
            C +K  +     RE+         +S + E+ E+VK+  K QE+ + + Q   V    P 
Sbjct: 955  CAVKPVVMLPIWRESLGHTRLHRMTSIEREEKEKVKKKEKKQEEEETMQQATWVKYTFPV 1014

Query: 446  RKLNKKKEKSKKEK----------KKEKV--------NNSNENPRKMCEQMR------LK 481
             K    K+K ++ +           K  V         N+N N RK  E  +      + 
Sbjct: 1015 -KHQVWKQKGEEYRVTGYGGWSWISKTHVYRFVPKLPGNTNVNYRKSLEGTKNNMDENMD 1073

Query: 482  EKSKR---NQPKKRKQQFIGLKSE--DEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHI 536
            E  KR     PKK K +    K E    D AK  + +E     ++I+K+   K   V  +
Sbjct: 1074 ESDKRKCSRSPKKIKIEPDSEKDEVKGSDAAKGADQNE-----MDISKITEKKDQDVKEL 1128

Query: 537  IQSREPSLSNSNPDEIEIDFETLKASTLRELEK----------YVSACLRKRPLKPPAKK 586
            + S         P E++ D +T      +E  +          ++    +K+        
Sbjct: 1129 LDSDSDKPCKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEGFHLRTSYKKKTKSSKLDG 1188

Query: 587  IMMSK-EELHSQKKQELEKRLLD------VNNQLNSRKRQTKSDK-TQPSKAVENVSRLS 638
            ++  + ++   ++KQ LEK  L+           NS K  ++S   T+  +  ++ S   
Sbjct: 1189 LLERRIKQFTLEEKQRLEKIKLEGGIKGIGKTSTNSSKNLSESPVITKAKEGCQSDSMRQ 1248

Query: 639  ESSSSSSSSSE-------SESSSSDLSSSDSSDSESEMFPK 672
            E S ++++          SES SS L  SD S + ++++PK
Sbjct: 1249 EQSPNANNDQPEDLIQGCSESDSSVLRMSDPSHTTNKLYPK 1289



 Score = 33.5 bits (75), Expect = 0.96
 Identities = 72/307 (23%), Positives = 118/307 (38%), Gaps = 62/307 (20%)

Query: 446  RKLNKKKEKSKKEKKKEKVNNSN-ENPRKMCEQMRLKEKSKRNQPKKRKQQFIGLKSEDE 504
            R +NK  ++ K +   +K NN N E+ +K       +   K N+PK      I LK E  
Sbjct: 1496 RPVNKCSDQIKLKNTTDKKNNENRESEKKGQRTSTFQINGKDNKPK------IYLKGE-- 1547

Query: 505  DNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPSLSNSNP--DEIEIDFETLKAS 562
                     E R +S N+                  EP ++N N    E +I   T+K S
Sbjct: 1548 ---CLKEISESRVVSGNV------------------EPKVNNINKIIPENDIKSLTVKES 1586

Query: 563  TLREL--EKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQT 620
             +R       +     +R      K  ++S  +     +  LE   L    + +S +  T
Sbjct: 1587 AIRPFINGDVIMEDFNERN-SSETKSHLLSSSDAEGNYRDSLE--TLPSTKESDSTQTTT 1643

Query: 621  KSDKTQPSKAVENVSRLSESSS------SSSSSSESESSSSD---------LSSSDSSDS 665
             S     S +V  V  +   +S      SS  +SE ES+ S+         ++ +++ + 
Sbjct: 1644 PSASCPESNSVNQVEDMEIETSEVKKVTSSPITSEEESNLSNDFIDENGLPINKNENVNG 1703

Query: 666  ESEMFPKFTEVKPNDS----PSKENVKKMKNECILPEGRTGVTQIGYCVQDT-TSANTTL 720
            ES+     TEV    S     SK  +K  K      + +T V+    C + T T+  TT+
Sbjct: 1704 ESKRKTVITEVTTMTSTVATESKTVIKVEKG-----DKQTVVSSTENCAKSTVTTTTTTV 1758

Query: 721  VHQTTPS 727
               +TPS
Sbjct: 1759 TKLSTPS 1765


>gi|38788274 bromodomain PHD finger transcription factor isoform 1
            [Homo sapiens]
          Length = 2920

 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 40/94 (42%), Positives = 54/94 (57%), Gaps = 2/94 (2%)

Query: 37   KVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIE 96
            K VL+ L  H  +WPF  PVD      PDYY +IK PMDL T+++R++ +YY K +E + 
Sbjct: 2811 KRVLRSLQAHKMAWPFLEPVDPN--DAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVA 2868

Query: 97   DFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKL 130
            D   +F NC  YN         A+ LE  F+QKL
Sbjct: 2869 DMTKIFDNCRYYNPSDSPFYQCAEVLESFFVQKL 2902



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 35/91 (38%), Positives = 51/91 (56%), Gaps = 5/91 (5%)

Query: 279  ILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFA 338
            +L+ + A K    AWPF  PVD N     +YY V+K PMDL T++E++  + Y+   +F 
Sbjct: 2813 VLRSLQAHK---MAWPFLEPVDPN--DAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFV 2867

Query: 339  ADVRLMFMNCYKYNPPDHEVVTMARMLQDVF 369
            AD+  +F NC  YNP D      A +L+  F
Sbjct: 2868 ADMTKIFDNCRYYNPSDSPFYQCAEVLESFF 2898



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 75/341 (21%), Positives = 134/341 (39%), Gaps = 61/341 (17%)

Query: 387  CYIKTDITETTGRENTNEASSEGNSSDDSED-ERVKRLAKLQEQLKAVHQQLQVLSQVPF 445
            C +K  +     RE+         +S + E+ E+VK+  K QE+ + + Q   V    P 
Sbjct: 829  CAVKPVVMLPIWRESLGHTRLHRMTSIEREEKEKVKKKEKKQEEEETMQQATWVKYTFPV 888

Query: 446  RKLNKKKEKSKKEK----------KKEKV--------NNSNENPRKMCEQMR------LK 481
             K    K+K ++ +           K  V         N+N N RK  E  +      + 
Sbjct: 889  -KHQVWKQKGEEYRVTGYGGWSWISKTHVYRFVPKLPGNTNVNYRKSLEGTKNNMDENMD 947

Query: 482  EKSKR---NQPKKRKQQFIGLKSE--DEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHI 536
            E  KR     PKK K +    K E    D AK  + +E     ++I+K+   K   V  +
Sbjct: 948  ESDKRKCSRSPKKIKIEPDSEKDEVKGSDAAKGADQNE-----MDISKITEKKDQDVKEL 1002

Query: 537  IQSREPSLSNSNPDEIEIDFETLKASTLRELEK----------YVSACLRKRPLKPPAKK 586
            + S         P E++ D +T      +E  +          ++    +K+        
Sbjct: 1003 LDSDSDKPCKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEGFHLRTSYKKKTKSSKLDG 1062

Query: 587  IMMSK-EELHSQKKQELEKRLLD------VNNQLNSRKRQTKSDK-TQPSKAVENVSRLS 638
            ++  + ++   ++KQ LEK  L+           NS K  ++S   T+  +  ++ S   
Sbjct: 1063 LLERRIKQFTLEEKQRLEKIKLEGGIKGIGKTSTNSSKNLSESPVITKAKEGCQSDSMRQ 1122

Query: 639  ESSSSSSSSSE-------SESSSSDLSSSDSSDSESEMFPK 672
            E S ++++          SES SS L  SD S + ++++PK
Sbjct: 1123 EQSPNANNDQPEDLIQGCSESDSSVLRMSDPSHTTNKLYPK 1163



 Score = 33.5 bits (75), Expect = 0.96
 Identities = 72/307 (23%), Positives = 118/307 (38%), Gaps = 62/307 (20%)

Query: 446  RKLNKKKEKSKKEKKKEKVNNSN-ENPRKMCEQMRLKEKSKRNQPKKRKQQFIGLKSEDE 504
            R +NK  ++ K +   +K NN N E+ +K       +   K N+PK      I LK E  
Sbjct: 1370 RPVNKCSDQIKLKNTTDKKNNENRESEKKGQRTSTFQINGKDNKPK------IYLKGE-- 1421

Query: 505  DNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPSLSNSNP--DEIEIDFETLKAS 562
                     E R +S N+                  EP ++N N    E +I   T+K S
Sbjct: 1422 ---CLKEISESRVVSGNV------------------EPKVNNINKIIPENDIKSLTVKES 1460

Query: 563  TLREL--EKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQT 620
             +R       +     +R      K  ++S  +     +  LE   L    + +S +  T
Sbjct: 1461 AIRPFINGDVIMEDFNERN-SSETKSHLLSSSDAEGNYRDSLE--TLPSTKESDSTQTTT 1517

Query: 621  KSDKTQPSKAVENVSRLSESSS------SSSSSSESESSSSD---------LSSSDSSDS 665
             S     S +V  V  +   +S      SS  +SE ES+ S+         ++ +++ + 
Sbjct: 1518 PSASCPESNSVNQVEDMEIETSEVKKVTSSPITSEEESNLSNDFIDENGLPINKNENVNG 1577

Query: 666  ESEMFPKFTEVKPNDS----PSKENVKKMKNECILPEGRTGVTQIGYCVQDT-TSANTTL 720
            ES+     TEV    S     SK  +K  K      + +T V+    C + T T+  TT+
Sbjct: 1578 ESKRKTVITEVTTMTSTVATESKTVIKVEKG-----DKQTVVSSTENCAKSTVTTTTTTV 1632

Query: 721  VHQTTPS 727
               +TPS
Sbjct: 1633 TKLSTPS 1639


>gi|40805843 K(lysine) acetyltransferase 2B [Homo sapiens]
          Length = 832

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 39/109 (35%), Positives = 58/109 (53%), Gaps = 2/109 (1%)

Query: 24  KNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRL 83
           K  R  +QL    K +L+ +  H  +WPF  PV   + + P YY +I+ PMDL T+ +RL
Sbjct: 720 KEPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVK--RTEAPGYYEVIRFPMDLKTMSERL 777

Query: 84  ENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQ 132
           +N+YY      + D   +F+NC  YN P  +    A  LEK F  K+ +
Sbjct: 778 KNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKE 826



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 41/99 (41%), Positives = 57/99 (57%), Gaps = 8/99 (8%)

Query: 280 LKEMLAK-KHFSYAWPFYNPVD-VNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKF 337
           LK +L + K    AWPF  PV    A G   YY+V++ PMDL T+ E++ N+ Y     F
Sbjct: 732 LKSILQQVKSHQSAWPFMEPVKRTEAPG---YYEVIRFPMDLKTMSERLKNRYYVSKKLF 788

Query: 338 AADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKI 376
            AD++ +F NC +YNPP+ E    A +L+  F   FSKI
Sbjct: 789 MADLQRVFTNCKEYNPPESEYYKCANILEKFF---FSKI 824


>gi|50345997 E1A binding protein p300 [Homo sapiens]
          Length = 2414

 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 73/279 (26%), Positives = 114/279 (40%), Gaps = 28/279 (10%)

Query: 131  SQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEI-----PSVFPKTS 185
            +Q+PQ+ Q            QQ      +   S P+ T  +   Q       P+V  +  
Sbjct: 891  TQLPQQVQPSLPAAPSADQPQQQPRSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQ 950

Query: 186  ISPLNVVQGASVNSSSQTAAQVTKGVKRKA----------DTTTPATSAVKA------SS 229
            +S         VNS +    Q ++ VK +A          DT     S  K       S+
Sbjct: 951  VSNPPSTSSTEVNSQAIAEKQPSQEVKMEAKMEVDQPEPADTQPEDISESKVEDCKMEST 1010

Query: 230  EFSPTFTEKSVALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHF 289
            E     TE    +   ++    +    S       K +   E+LR       E L ++  
Sbjct: 1011 ETEERSTELKTEIKEEEDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQD- 1069

Query: 290  SYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCY 349
              + PF  PVD   LG+ +Y+D+VK+PMDL TIK K+D  +Y++ +++  D+ LMF N +
Sbjct: 1070 PESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAW 1129

Query: 350  KYNPPDHEVVTMARMLQDVFETHFSKIPIEPV-ESMPLC 387
             YN     V      L +VFE       I+PV +S+  C
Sbjct: 1130 LYNRKTSRVYKYCSKLSEVFEQE-----IDPVMQSLGYC 1163



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 32/87 (36%), Positives = 55/87 (63%)

Query: 49   SWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLY 108
            S PF++PVD   L +PDY+ I+K+PMDL+TIK++L+   Y +  + ++D   MF+N +LY
Sbjct: 1072 SLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLY 1131

Query: 109  NKPGDDIVLMAQALEKLFMQKLSQMPQ 135
            N+    +      L ++F Q++  + Q
Sbjct: 1132 NRKTSRVYKYCSKLSEVFEQEIDPVMQ 1158



 Score = 30.4 bits (67), Expect = 8.2
 Identities = 26/113 (23%), Positives = 43/113 (38%), Gaps = 3/113 (2%)

Query: 579  PLKPPAKKIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLS 638
            PL  PA  I        S    E+  + +         K + K +  QP  A      +S
Sbjct: 939  PLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEKQPSQEVKMEAKMEVDQPEPADTQPEDIS 998

Query: 639  ES--SSSSSSSSESESSSSDLSSSDSSDSESEMFPKFTEVKPNDSPSKENVKK 689
            ES        S+E+E  S++L  ++  + E +     T+  P    SK+ + K
Sbjct: 999  ESKVEDCKMESTETEERSTEL-KTEIKEEEDQPSTSATQSSPAPGQSKKKIFK 1050


>gi|119943102 CREB binding protein isoform b [Homo sapiens]
          Length = 2404

 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 40/95 (42%), Positives = 56/95 (58%), Gaps = 6/95 (6%)

Query: 294  PFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNP 353
            PF  PVD   LG+ +Y+D+VKNPMDL TIK K+D  +Y++ +++  DV LMF N + YN 
Sbjct: 1072 PFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNR 1131

Query: 354  PDHEVVTMARMLQDVFETHFSKIPIEPV-ESMPLC 387
                V      L +VFE       I+PV +S+  C
Sbjct: 1132 KTSRVYKFCSKLAEVFEQE-----IDPVMQSLGYC 1161



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 33/87 (37%), Positives = 55/87 (63%)

Query: 49   SWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLY 108
            S PF++PVD   L +PDY+ I+KNPMDL+TIK++L+   Y +  + ++D   MF+N +LY
Sbjct: 1070 SLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLY 1129

Query: 109  NKPGDDIVLMAQALEKLFMQKLSQMPQ 135
            N+    +      L ++F Q++  + Q
Sbjct: 1130 NRKTSRVYKFCSKLAEVFEQEIDPVMQ 1156


>gi|119943104 CREB binding protein isoform a [Homo sapiens]
          Length = 2442

 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 40/95 (42%), Positives = 56/95 (58%), Gaps = 6/95 (6%)

Query: 294  PFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNP 353
            PF  PVD   LG+ +Y+D+VKNPMDL TIK K+D  +Y++ +++  DV LMF N + YN 
Sbjct: 1110 PFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNR 1169

Query: 354  PDHEVVTMARMLQDVFETHFSKIPIEPV-ESMPLC 387
                V      L +VFE       I+PV +S+  C
Sbjct: 1170 KTSRVYKFCSKLAEVFEQE-----IDPVMQSLGYC 1199



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 33/87 (37%), Positives = 55/87 (63%)

Query: 49   SWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLY 108
            S PF++PVD   L +PDY+ I+KNPMDL+TIK++L+   Y +  + ++D   MF+N +LY
Sbjct: 1108 SLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLY 1167

Query: 109  NKPGDDIVLMAQALEKLFMQKLSQMPQ 135
            N+    +      L ++F Q++  + Q
Sbjct: 1168 NRKTSRVYKFCSKLAEVFEQEIDPVMQ 1194


>gi|47419911 transcriptional intermediary factor 1 alpha isoform a
            [Homo sapiens]
          Length = 1050

 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 41/98 (41%), Positives = 57/98 (58%), Gaps = 5/98 (5%)

Query: 43   LWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKY--YAKASECIEDFNT 100
            L+ H  S  FQ PV    L +PDYY IIKNPMDL+TIKKRL+  Y  Y+K  + + DF  
Sbjct: 915  LYCHEMSLAFQDPVP---LTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRL 971

Query: 101  MFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQ 138
            +F NC  +N+P  ++      LE  F + L  +  E++
Sbjct: 972  IFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKR 1009



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 44/137 (32%), Positives = 66/137 (48%), Gaps = 16/137 (11%)

Query: 295  FYNPVDVNALGLHNYYDVVKNPMDLGTIKEKM--DNQEYKDAYKFAADVRLMFMNCYKYN 352
            F +PV    L + +YY ++KNPMDL TIK+++  D   Y     F AD RL+F NC ++N
Sbjct: 924  FQDPVP---LTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFN 980

Query: 353  PPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSS 412
             PD EV      L++ FE           E +   Y +    +   R  + +     +S 
Sbjct: 981  EPDSEVANAGIKLENYFE-----------ELLKNLYPEKRFPKPEFRNESEDNKFSDDSD 1029

Query: 413  DDSEDERVKRLAKLQEQ 429
            DD    R KRL  ++E+
Sbjct: 1030 DDFVQPRKKRLKSIEER 1046


>gi|47419909 transcriptional intermediary factor 1 alpha isoform b
           [Homo sapiens]
          Length = 1016

 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 41/98 (41%), Positives = 57/98 (58%), Gaps = 5/98 (5%)

Query: 43  LWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKY--YAKASECIEDFNT 100
           L+ H  S  FQ PV    L +PDYY IIKNPMDL+TIKKRL+  Y  Y+K  + + DF  
Sbjct: 881 LYCHEMSLAFQDPVP---LTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRL 937

Query: 101 MFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQ 138
           +F NC  +N+P  ++      LE  F + L  +  E++
Sbjct: 938 IFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKR 975



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 44/137 (32%), Positives = 66/137 (48%), Gaps = 16/137 (11%)

Query: 295  FYNPVDVNALGLHNYYDVVKNPMDLGTIKEKM--DNQEYKDAYKFAADVRLMFMNCYKYN 352
            F +PV    L + +YY ++KNPMDL TIK+++  D   Y     F AD RL+F NC ++N
Sbjct: 890  FQDPVP---LTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFN 946

Query: 353  PPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSS 412
             PD EV      L++ FE           E +   Y +    +   R  + +     +S 
Sbjct: 947  EPDSEVANAGIKLENYFE-----------ELLKNLYPEKRFPKPEFRNESEDNKFSDDSD 995

Query: 413  DDSEDERVKRLAKLQEQ 429
            DD    R KRL  ++E+
Sbjct: 996  DDFVQPRKKRLKSIEER 1012


>gi|153791535 general control of amino acid synthesis 5-like 2 [Homo
           sapiens]
          Length = 837

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 38/103 (36%), Positives = 55/103 (53%), Gaps = 2/103 (1%)

Query: 30  NQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYA 89
           +QL    K +L  +  H  +WPF  PV   K + PDYY +I+ P+DL T+ +RL ++YY 
Sbjct: 731 DQLYTTLKNLLAQIKSHPSAWPFMEPVK--KSEAPDYYEVIRFPIDLKTMTERLRSRYYV 788

Query: 90  KASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQ 132
                + D   + +NC  YN P  +    A ALEK F  KL +
Sbjct: 789 TRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFKLKE 831



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 34/91 (37%), Positives = 52/91 (57%), Gaps = 3/91 (3%)

Query: 280 LKEMLAK-KHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFA 338
           LK +LA+ K    AWPF  PV  +     +YY+V++ P+DL T+ E++ ++ Y     F 
Sbjct: 737 LKNLLAQIKSHPSAWPFMEPVKKSEAP--DYYEVIRFPIDLKTMTERLRSRYYVTRKLFV 794

Query: 339 ADVRLMFMNCYKYNPPDHEVVTMARMLQDVF 369
           AD++ +  NC +YNPPD E    A  L+  F
Sbjct: 795 ADLQRVIANCREYNPPDSEYCRCASALEKFF 825


>gi|148612882 cat eye syndrome chromosome region, candidate 2 [Homo
           sapiens]
          Length = 1484

 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 45/125 (36%), Positives = 63/125 (50%), Gaps = 5/125 (4%)

Query: 3   LPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWK-HSFSWPFQRPVDAVKL 61
           LP   + +  N P  E   TK    L +    + KV+  D+ K H  SWPF  PVD  + 
Sbjct: 411 LPPELSHLDPNSPMREEKKTKDLFELDDDFTAMYKVL--DVVKAHKDSWPFLEPVD--ES 466

Query: 62  QLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQA 121
             P+YY IIK PMD+++++K+L    Y    E + D  TMF NC  YN    +   M+  
Sbjct: 467 YAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDN 526

Query: 122 LEKLF 126
           LE+ F
Sbjct: 527 LERCF 531



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 29/84 (34%), Positives = 45/84 (53%), Gaps = 2/84 (2%)

Query: 292 AWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKY 351
           +WPF  PVD +     NYY ++K PMD+ ++++K++   Y    +F  D++ MF NC KY
Sbjct: 456 SWPFLEPVDESYAP--NYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKY 513

Query: 352 NPPDHEVVTMARMLQDVFETHFSK 375
           N    E   M+  L+  F     K
Sbjct: 514 NGESSEYTKMSDNLERCFHRAMMK 537


>gi|32967605 bromodomain adjacent to zinc finger domain, 1A isoform b
            [Homo sapiens]
          Length = 1524

 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 39/97 (40%), Positives = 60/97 (61%), Gaps = 5/97 (5%)

Query: 15   PPPEYINTKKNGRL--TNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKN 72
            P P  +  + +GR    ++L   +++V+ +L +H  SWPF + V   K+Q+PDYY IIK 
Sbjct: 1384 PSPVTLGRRSSGRQGGVHELSAFEQLVV-ELVRHDDSWPFLKLVS--KIQVPDYYDIIKK 1440

Query: 73   PMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYN 109
            P+ LN I++++    Y  ASE I+D   MFSNC+ YN
Sbjct: 1441 PIALNIIREKVNKCEYKLASEFIDDIELMFSNCFEYN 1477



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 32/92 (34%), Positives = 50/92 (54%), Gaps = 2/92 (2%)

Query: 292  AWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKY 351
            +WPF   V  + + + +YYD++K P+ L  I+EK++  EYK A +F  D+ LMF NC++Y
Sbjct: 1419 SWPFLKLV--SKIQVPDYYDIIKKPIALNIIREKVNKCEYKLASEFIDDIELMFSNCFEY 1476

Query: 352  NPPDHEVVTMARMLQDVFETHFSKIPIEPVES 383
            NP +         LQ  F     K+ +    S
Sbjct: 1477 NPRNTSEAKAGTRLQAFFHIQAQKLGLHVTPS 1508



 Score = 35.8 bits (81), Expect = 0.19
 Identities = 27/124 (21%), Positives = 63/124 (50%), Gaps = 5/124 (4%)

Query: 400 ENTNEASSEGNSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKLN-KKKEKSKKE 458
           +  N A+ +  +S  S+  + +     QE++K++  +   L +     L  KKKEK  KE
Sbjct: 287 QEDNVANKQTLASYRSKATKERDKLLKQEEMKSLAFEKAKLKREKADALEAKKKEKEDKE 346

Query: 459 KKKEKVNNSNENPR----KMCEQMRLKEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDE 514
           KK+E++    E  R    +  E+++++ + +R + ++ K++++    +     + M  D+
Sbjct: 347 KKREELKKIVEEERLKKKEEKERLKVEREKEREKLREEKRKYVEYLKQWSKPREDMECDD 406

Query: 515 KRQL 518
            ++L
Sbjct: 407 LKEL 410


>gi|32967603 bromodomain adjacent to zinc finger domain, 1A isoform a
            [Homo sapiens]
          Length = 1556

 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 39/97 (40%), Positives = 60/97 (61%), Gaps = 5/97 (5%)

Query: 15   PPPEYINTKKNGRL--TNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKN 72
            P P  +  + +GR    ++L   +++V+ +L +H  SWPF + V   K+Q+PDYY IIK 
Sbjct: 1416 PSPVTLGRRSSGRQGGVHELSAFEQLVV-ELVRHDDSWPFLKLVS--KIQVPDYYDIIKK 1472

Query: 73   PMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYN 109
            P+ LN I++++    Y  ASE I+D   MFSNC+ YN
Sbjct: 1473 PIALNIIREKVNKCEYKLASEFIDDIELMFSNCFEYN 1509



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 32/92 (34%), Positives = 50/92 (54%), Gaps = 2/92 (2%)

Query: 292  AWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKY 351
            +WPF   V  + + + +YYD++K P+ L  I+EK++  EYK A +F  D+ LMF NC++Y
Sbjct: 1451 SWPFLKLV--SKIQVPDYYDIIKKPIALNIIREKVNKCEYKLASEFIDDIELMFSNCFEY 1508

Query: 352  NPPDHEVVTMARMLQDVFETHFSKIPIEPVES 383
            NP +         LQ  F     K+ +    S
Sbjct: 1509 NPRNTSEAKAGTRLQAFFHIQAQKLGLHVTPS 1540



 Score = 35.8 bits (81), Expect = 0.19
 Identities = 27/124 (21%), Positives = 63/124 (50%), Gaps = 5/124 (4%)

Query: 400 ENTNEASSEGNSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKLN-KKKEKSKKE 458
           +  N A+ +  +S  S+  + +     QE++K++  +   L +     L  KKKEK  KE
Sbjct: 287 QEDNVANKQTLASYRSKATKERDKLLKQEEMKSLAFEKAKLKREKADALEAKKKEKEDKE 346

Query: 459 KKKEKVNNSNENPR----KMCEQMRLKEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDE 514
           KK+E++    E  R    +  E+++++ + +R + ++ K++++    +     + M  D+
Sbjct: 347 KKREELKKIVEEERLKKKEEKERLKVEREKEREKLREEKRKYVEYLKQWSKPREDMECDD 406

Query: 515 KRQL 518
            ++L
Sbjct: 407 LKEL 410


>gi|94681063 bromodomain adjacent to zinc finger domain, 2B [Homo
            sapiens]
          Length = 2168

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 55/199 (27%), Positives = 91/199 (45%), Gaps = 22/199 (11%)

Query: 178  PSVFPKTSISPLNV----VQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSP 233
            P+   K S   L +    V+G   N S +       G     D+ + ++S  + + +   
Sbjct: 1976 PACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKK 2035

Query: 234  TFTEKSVALPPIKENMPKNVLPDSQQQYNVVKTVKV--TEQLRHCSEILKEMLAKKHFSY 291
               E++ ++     N+ K      Q+ +  VK  K   ++ L  CS IL EM   +    
Sbjct: 2036 RKMEENTSI-----NLSK------QESFTSVKKPKRDDSKDLALCSMILTEMETHED--- 2081

Query: 292  AWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKY 351
            AWPF  PV++  +    Y  V+K PMD  TI+EK+ + +Y +   FA DVRL+F NC  +
Sbjct: 2082 AWPFLLPVNLKLVP--GYKKVIKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETF 2139

Query: 352  NPPDHEVVTMARMLQDVFE 370
            N  D ++      ++  FE
Sbjct: 2140 NEDDSDIGRAGHNMRKYFE 2158



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 34/111 (30%), Positives = 57/111 (51%), Gaps = 2/111 (1%)

Query: 19   YINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNT 78
            + + KK  R  ++   L  ++L ++  H  +WPF  PV+ +KL +P Y  +IK PMD +T
Sbjct: 2052 FTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVN-LKL-VPGYKKVIKKPMDFST 2109

Query: 79   IKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQK 129
            I+++L +  Y        D   +F NC  +N+   DI      + K F +K
Sbjct: 2110 IREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKK 2160



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 38/120 (31%), Positives = 55/120 (45%), Gaps = 11/120 (9%)

Query: 610 NNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSSDSSD---SE 666
           N  L++R  + K DK    KA+E     S S+S S S + S++SS  +SSSDS D    E
Sbjct: 219 NQPLDARVDKIK-DKKPRKKAME-----SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDE 272

Query: 667 SEMFPKFTEVKPNDSPSKENVKKMKNECILPEGRTGVTQIGYCVQDTTSANTTLVHQTTP 726
            E      E + +DS S+   +   N  +L  G +     G   + T  A    +HQ  P
Sbjct: 273 EEEDQSIEESEDDDSDSESEAQHKSNNQVLLHGISDPKADGQ--KATEKAQEKRIHQPLP 330



 Score = 37.0 bits (84), Expect = 0.087
 Identities = 55/245 (22%), Positives = 97/245 (39%), Gaps = 36/245 (14%)

Query: 598 KKQELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSS-----SSESES 652
           K Q L+ R+  + ++   RK+  +S     S +  +    SE  SSS S       E E 
Sbjct: 218 KNQPLDARVDKIKDK-KPRKKAMESSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEED 276

Query: 653 SSSDLSSSDSSDSESEMFPK---------FTEVKPNDSPSKENVKKMKNECILP---EGR 700
            S + S  D SDSESE   K          ++ K +   + E  ++ +    LP   E +
Sbjct: 277 QSIEESEDDDSDSESEAQHKSNNQVLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQ 336

Query: 701 TGVTQIGYCVQDTTSANTTLVHQTTPSHVMPPNHHQ-------LAFNYQELEHLQTVKNI 753
           T   Q         S     + Q++ +     N H        L  N + L  +   K  
Sbjct: 337 THSFQSQQKQPQVLSQQLPFIFQSSQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKE 396

Query: 754 SPLQILPPSGDSEQLSNGITVMHPSGDSDTTMLESECQAPVQK-----DIKIKNADSWKS 808
           + ++++ PS D  +  N  T        ++++L SE ++  ++       ++K  +S KS
Sbjct: 397 TYMKLIVPSPDVLKAGNKNT------SEESSLLTSELRSKREQYKQAFPSQLKKQESSKS 450

Query: 809 LGKPV 813
           L K +
Sbjct: 451 LKKVI 455



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 33/112 (29%), Positives = 58/112 (51%), Gaps = 25/112 (22%)

Query: 425  KLQEQLKAVHQQLQV--LSQVPFRK-LNKKKEKSKKEKKKEKVNNSNENPRKMCE-QMRL 480
            K +EQ+K + QQ ++  + Q+   K L  ++    K+KKKE+  N+     K+ E + R+
Sbjct: 933  KQKEQIKIMKQQEKIKRIQQIRMEKELRAQQILEAKKKKKEEAANA-----KLLEAEKRI 987

Query: 481  KEKSKR--------NQPKKRKQQFIGL--------KSEDEDNAKPMNYDEKR 516
            KEK  R        +Q ++R++Q + L        K+E+++  K    DEKR
Sbjct: 988  KEKEMRRQQAVLLKHQERERRRQHMMLMKAMEARKKAEEKERLKQEKRDEKR 1039



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 71/329 (21%), Positives = 127/329 (38%), Gaps = 48/329 (14%)

Query: 382 ESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERVKRLAKLQEQLKAVHQQLQVLS 441
           + +P  +  +   E +  ++T+   S G  S+      VK L+ + +  K  + +L V S
Sbjct: 352 QQLPFIFQSSQAKEESVNKHTSVIQSTGLVSN------VKPLSLVNQAKKETYMKLIVPS 405

Query: 442 QVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRLKEKSKRNQPKKRKQQFIGLKS 501
               +  NK   +       E  +   +  +    Q++ +E SK       K+    L +
Sbjct: 406 PDVLKAGNKNTSEESSLLTSELRSKREQYKQAFPSQLKKQESSK-----SLKKVIAALSN 460

Query: 502 EDEDNAKPMNYDEKRQLSLN------INKLPGDKL--GRVVHIIQSREPSLSNSNPDEIE 553
               ++ P +   K+ L  N       N L G+    G +  +IQ    +L+     + +
Sbjct: 461 PKATSSSPAH--PKQTLENNHPNPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSK 518

Query: 554 IDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEE-LHSQKKQELEKRLLDVNNQ 612
           I+ E + A++       V+     R        +M S    LHSQ K++       V+N 
Sbjct: 519 IN-ENIAAASSTPFSSPVNLSTSGRRTPGNQTPVMPSASPILHSQGKEKA------VSNN 571

Query: 613 LNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSES-------------ESSSSDLSS 659
           +N  K Q  S    P+K++    R ++S   SS  SE              E    D  S
Sbjct: 572 VNPVKTQHHS---HPAKSLVEQFRGTDSDIPSSKDSEDSNEDEEEDDEEEDEEDDEDDES 628

Query: 660 SDS---SDSESEMFPKFTEVKPNDSPSKE 685
            DS   SDS SE   + +E + +D   ++
Sbjct: 629 DDSQSESDSNSESDTEGSEEEDDDDKDQD 657



 Score = 33.5 bits (75), Expect = 0.96
 Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 9/93 (9%)

Query: 424 AKLQEQLKAVHQQLQVLSQVPFRKLNKKKE-KSKKEKKKEKVNNSNENPRKMCEQ---MR 479
           AKL  +L+A     Q       RKL K+++ +  KE KK++   + E  RK  EQ   M+
Sbjct: 883 AKLLRKLQAQEIARQAAQIKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMK 942

Query: 480 LKEKSKRNQ-----PKKRKQQFIGLKSEDEDNA 507
            +EK KR Q      + R QQ +  K + ++ A
Sbjct: 943 QQEKIKRIQQIRMEKELRAQQILEAKKKKKEEA 975


>gi|34996489 pleckstrin homology domain interacting protein [Homo
            sapiens]
          Length = 1821

 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 52/183 (28%), Positives = 83/183 (45%), Gaps = 16/183 (8%)

Query: 246  KENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALG 305
            K++ P+  L +  Q Y++    K       C E+L  +   +      PF  PVD+  L 
Sbjct: 1301 KDHQPRRRLRNRAQSYDIQAWKK------QCEELLNLIFQCEDSE---PFRQPVDL--LE 1349

Query: 306  LHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDH-EVVTMARM 364
              +Y D++  PMD  T++E ++   Y+   +   DVRL+F N   Y P     + +M+  
Sbjct: 1350 YPDYRDIIDTPMDFATVRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKRSRIYSMSLR 1409

Query: 365  LQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERVKRLA 424
            L   FE H S + +   +S    + +  IT+   R      SS  +SS  S  ER KR+ 
Sbjct: 1410 LSAFFEEHISSV-LSDYKSALRFHKRNTITK---RRKKRNRSSSVSSSAASSPERKKRIL 1465

Query: 425  KLQ 427
            K Q
Sbjct: 1466 KPQ 1468



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 56/208 (26%), Positives = 91/208 (43%), Gaps = 24/208 (11%)

Query: 49   SWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLY 108
            S PF++PVD   L+ PDY  II  PMD  T+++ LE   Y    E  +D   +FSN   Y
Sbjct: 1338 SEPFRQPVDL--LEYPDYRDIIDTPMDFATVRETLEAGNYESPMELCKDVRLIFSNSKAY 1395

Query: 109  N-KPGDDIVLMAQALEKLFMQKLSQMPQE--------EQVVGVKERIKKGTQQNIAVSSA 159
                   I  M+  L   F + +S +  +        ++    K R K+    +++ S+A
Sbjct: 1396 TPSKRSRIYSMSLRLSAFFEEHISSVLSDYKSALRFHKRNTITKRRKKRNRSSSVSSSAA 1455

Query: 160  KEKSSPSATEKVFKQQ----EIPSVF--PKTSISPLNVVQGASVNSSSQTAAQVTKGVKR 213
               SSP   +++ K Q       S F  P  SI P +    A +N  +++++ V     R
Sbjct: 1456 ---SSPERKKRILKPQLKSESSTSAFSTPTRSIPPRH--NAAQINGKTESSSVVRTRSNR 1510

Query: 214  KADTTTPATSAVKASSEFSPTFTEKSVA 241
                  P  +   ++S  + TF  K+ A
Sbjct: 1511 V--VVDPVVTEQPSTSSAAKTFITKANA 1536



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 141/660 (21%), Positives = 248/660 (37%), Gaps = 79/660 (11%)

Query: 276  CSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAY 335
            C  I+  +        A  F  PVD+ A  +  Y  VV  P DL TIK++++N+ Y+   
Sbjct: 1165 CERIVAGINQLMTLDIASAFVAPVDLQAYPM--YCTVVAYPTDLSTIKQRLENRFYRRVS 1222

Query: 336  KFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCYIKTDITE 395
                +VR +  N   +N P   +V  A+ + D+   HF K        +PL         
Sbjct: 1223 SLMWEVRYIEHNTRTFNEPGSPIVKSAKFVTDLL-LHFIK-DQTCYNIIPLYNSMKKKVL 1280

Query: 396  TTGRENTNEASSEGNSSDDSEDERVKRLAK-------LQEQLKAVHQQLQVLSQV----P 444
            +   +   +A   G S+   +D + +R  +       +Q   K   + L ++ Q     P
Sbjct: 1281 SDSEDEEKDADVPGTSTRKRKDHQPRRRLRNRAQSYDIQAWKKQCEELLNLIFQCEDSEP 1340

Query: 445  FRK-------------LNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRL-KEKSKRNQPK 490
            FR+             ++   + +   +  E  N   E+P ++C+ +RL    SK   P 
Sbjct: 1341 FRQPVDLLEYPDYRDIIDTPMDFATVRETLEAGN--YESPMELCKDVRLIFSNSKAYTPS 1398

Query: 491  KRKQQF---IGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPSLSNS 547
            KR + +   + L +  E++   +  D K  L  +       +  +     ++R  S+S+S
Sbjct: 1399 KRSRIYSMSLRLSAFFEEHISSVLSDYKSALRFHKRNTITKRRKK-----RNRSSSVSSS 1453

Query: 548  NPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQELEKRLL 607
                 E     LK     + E   SA        PP         +  S          +
Sbjct: 1454 AASSPERKKRILKPQL--KSESSTSAFSTPTRSIPPRHNAAQINGKTESSSVVRTRSNRV 1511

Query: 608  DVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSSDSSDSES 667
             V+  +  +   + + KT  +KA  N S +   +   +S   S++ ++  S   SS S  
Sbjct: 1512 VVDPVVTEQPSTSSAAKTFITKA--NASAIPGKTILENSVKHSKALNTLSSPGQSSFSHG 1569

Query: 668  EMFPKFTEVKPNDSPSKENVKKMKNECILPEGRT-----GVTQIGYCVQDTTSANTTLV- 721
                +    K N    K   +KMK+  +LP+  T      V + G C  +     T  V 
Sbjct: 1570 ---TRNNSAKENMEKEKPVKRKMKSS-VLPKASTLSKSSAVIEQGDCKNNALVPGTIQVN 1625

Query: 722  -HQTTPSHVMP--PNHH---QLAFNYQELEHLQTVKNISPLQILPPSGDSEQLSNGITVM 775
             H   PS ++   P      ++  N  E+ H +  +    LQ   P  D EQ +     +
Sbjct: 1626 GHGGQPSKLVKRGPGRKPKVEVNTNSGEIIHKKRGRKPKKLQYAKPE-DLEQNN-----V 1679

Query: 776  HPSGD----SDTTMLESECQAPVQKDIKIKNADSWKSLGKPVKPSGVMKSSDELFNQFRK 831
            HP  D    S T    SE     +  ++ KN    +   KP +     K   +L      
Sbjct: 1680 HPIRDEVLPSSTCNFLSETNNVKEDLLQKKN----RGGRKPKRKMKTQKLDADLLVPASV 1735

Query: 832  AAIEKEVKARTQELIRKHLEQNTKELKASQENQRDLGNGLTVESFSNKIQNKCSGEEQKE 891
              + +  + +  + I +  E+  +ELK S+ + R    G    +F N+     S EEQ++
Sbjct: 1736 KVLRRSNRKKIDDPIDE--EEEFEELKGSEPHMRTRNQGRRT-AFYNEDD---SEEEQRQ 1789



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 27/76 (35%), Positives = 42/76 (55%), Gaps = 2/76 (2%)

Query: 52   FQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKP 111
            F  PVD      P Y T++  P DL+TIK+RLEN++Y + S  + +   +  N   +N+P
Sbjct: 1184 FVAPVDLQAY--PMYCTVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEP 1241

Query: 112  GDDIVLMAQALEKLFM 127
            G  IV  A+ +  L +
Sbjct: 1242 GSPIVKSAKFVTDLLL 1257



 Score = 38.1 bits (87), Expect = 0.039
 Identities = 39/134 (29%), Positives = 56/134 (41%), Gaps = 8/134 (5%)

Query: 566 ELEKYVSACLRKRPLKPPAKKI-MMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTKSDK 624
           E++ Y S   RK    P   KI  +SK   H +   +L +      NQ N R R    + 
Sbjct: 747 EIKTYRSEEKRKHLTVPKENKIPTVSKNHAH-EHFLDLGESKKQQTNQHNYRTRSALEET 805

Query: 625 TQPSKAVENVSRLSESS-----SSSSSSSESESSSSDLSSSD-SSDSESEMFPKFTEVKP 678
            +PS+ +EN S  S+       S  +S  E  +  SD SSSD SSD           ++P
Sbjct: 806 PRPSEEIENGSSSSDEGEVVAVSGGTSEEEERAWHSDGSSSDYSSDYSDWTADAGINLQP 865

Query: 679 NDSPSKENVKKMKN 692
                K   KK ++
Sbjct: 866 PKKVPKNKTKKAES 879



 Score = 33.5 bits (75), Expect = 0.96
 Identities = 27/101 (26%), Positives = 44/101 (43%), Gaps = 10/101 (9%)

Query: 397 TGRENTNEASSEGNSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKS- 455
           T  E      S+G+SSD S D          +        LQ   +VP  K  K +  S 
Sbjct: 831 TSEEEERAWHSDGSSSDYSSD--------YSDWTADAGINLQPPKKVPKNKTKKAESSSD 882

Query: 456 -KKEKKKEKVNNSNENPRKMCEQMRLKEKSKRNQPKKRKQQ 495
            ++E +K+K     +  +K+ E+       K+ +PK+RKQ+
Sbjct: 883 EEEESEKQKQKQIKKEKKKVNEEKDGPISPKKKKPKERKQK 923


>gi|74027251 tripartite motif-containing 33 protein isoform beta [Homo
            sapiens]
          Length = 1110

 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 40/139 (28%), Positives = 67/139 (48%), Gaps = 8/139 (5%)

Query: 43   LWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENK---YYAKASECIEDFN 99
            L+ H  S  FQ PV A    +P+YY IIK PMDL+T+KK+L+ K   +Y    + + D  
Sbjct: 973  LYCHELSIEFQEPVPA---SIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVR 1029

Query: 100  TMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSA 159
             +F NC  +N+   ++    +A+   F  KL+++  +     + E  ++     +   S 
Sbjct: 1030 LIFKNCERFNEADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSD 1089

Query: 160  KEKSSPSATEKVFKQQEIP 178
            ++   P    K  K  E P
Sbjct: 1090 EDFIQP--RRKRLKSDERP 1106



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 32/85 (37%), Positives = 48/85 (56%), Gaps = 6/85 (7%)

Query: 295  FYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMD---NQEYKDAYKFAADVRLMFMNCYKY 351
            F  PV  +   + NYY ++K PMDL T+K+K+    +Q Y+    F ADVRL+F NC ++
Sbjct: 982  FQEPVPAS---IPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERF 1038

Query: 352  NPPDHEVVTMARMLQDVFETHFSKI 376
            N  D EV    + +   FE   ++I
Sbjct: 1039 NEADSEVAQAGKAVALYFEDKLTEI 1063


>gi|20357588 TBP-associated factor 1 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 44/153 (28%), Positives = 71/153 (46%), Gaps = 6/153 (3%)

Query: 35   LQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASEC 94
            L  +V + +     SWPF  PV+  K  +PDYY +I NPMDL TI+K +    Y      
Sbjct: 1511 LDNIVTQKMMAVPDSWPFHHPVN--KKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESF 1568

Query: 95   IEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNI 154
            ++D N + +N   YN P       AQ +  +  Q L++   +E +  +++ I   T +  
Sbjct: 1569 LDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTE--YDEHLTQLEKDI--CTAKEA 1624

Query: 155  AVSSAKEKSSPSATEKVFKQQEIPSVFPKTSIS 187
            A+  A+ +S    T   +  Q        TS+S
Sbjct: 1625 ALEEAELESLDPMTPGPYTPQPPDLYDTNTSLS 1657



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 32/94 (34%), Positives = 53/94 (56%), Gaps = 4/94 (4%)

Query: 277  SEILKEMLAKKHFSY--AWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDA 334
            S IL  ++ +K  +   +WPF++PV  N   + +YY V+ NPMDL TI++ +   +Y+  
Sbjct: 1508 SFILDNIVTQKMMAVPDSWPFHHPV--NKKFVPDYYKVIVNPMDLETIRKNISKHKYQSR 1565

Query: 335  YKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDV 368
              F  DV L+  N  KYN P+ +    A+ + +V
Sbjct: 1566 ESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV 1599



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 30/115 (26%), Positives = 60/115 (52%), Gaps = 4/115 (3%)

Query: 32   LQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKA 91
            L  + + ++ D+     ++PF  PV+A  ++  DYY II  PMDL T+++ +  + Y   
Sbjct: 1385 LSSILESIINDMRDLPNTYPFHTPVNAKVVK--DYYKIITRPMDLQTLRENVRKRLYPSR 1442

Query: 92   SECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQVVGVKERI 146
             E  E    +  N   YN P   +  ++Q++  L  +KL +  +E+++  +++ I
Sbjct: 1443 EEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKE--KEDKLARLEKAI 1495



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 27/100 (27%), Positives = 52/100 (52%), Gaps = 3/100 (3%)

Query: 270  TEQLRHCSEILKEMLAK-KHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDN 328
            T+ +   S IL+ ++   +     +PF+ PV  NA  + +YY ++  PMDL T++E +  
Sbjct: 1379 TDPMVTLSSILESIINDMRDLPNTYPFHTPV--NAKVVKDYYKIITRPMDLQTLRENVRK 1436

Query: 329  QEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDV 368
            + Y    +F   + L+  N   YN P H +  +++ + D+
Sbjct: 1437 RLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDL 1476


>gi|20357585 TBP-associated factor 1 isoform 1 [Homo sapiens]
          Length = 1893

 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 44/153 (28%), Positives = 71/153 (46%), Gaps = 6/153 (3%)

Query: 35   LQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASEC 94
            L  +V + +     SWPF  PV+  K  +PDYY +I NPMDL TI+K +    Y      
Sbjct: 1532 LDNIVTQKMMAVPDSWPFHHPVN--KKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESF 1589

Query: 95   IEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNI 154
            ++D N + +N   YN P       AQ +  +  Q L++   +E +  +++ I   T +  
Sbjct: 1590 LDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTE--YDEHLTQLEKDI--CTAKEA 1645

Query: 155  AVSSAKEKSSPSATEKVFKQQEIPSVFPKTSIS 187
            A+  A+ +S    T   +  Q        TS+S
Sbjct: 1646 ALEEAELESLDPMTPGPYTPQPPDLYDTNTSLS 1678



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 32/94 (34%), Positives = 53/94 (56%), Gaps = 4/94 (4%)

Query: 277  SEILKEMLAKKHFSY--AWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDA 334
            S IL  ++ +K  +   +WPF++PV  N   + +YY V+ NPMDL TI++ +   +Y+  
Sbjct: 1529 SFILDNIVTQKMMAVPDSWPFHHPV--NKKFVPDYYKVIVNPMDLETIRKNISKHKYQSR 1586

Query: 335  YKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDV 368
              F  DV L+  N  KYN P+ +    A+ + +V
Sbjct: 1587 ESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV 1620



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 30/115 (26%), Positives = 60/115 (52%), Gaps = 4/115 (3%)

Query: 32   LQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKA 91
            L  + + ++ D+     ++PF  PV+A  ++  DYY II  PMDL T+++ +  + Y   
Sbjct: 1406 LSSILESIINDMRDLPNTYPFHTPVNAKVVK--DYYKIITRPMDLQTLRENVRKRLYPSR 1463

Query: 92   SECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQVVGVKERI 146
             E  E    +  N   YN P   +  ++Q++  L  +KL +  +E+++  +++ I
Sbjct: 1464 EEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKE--KEDKLARLEKAI 1516



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 27/100 (27%), Positives = 52/100 (52%), Gaps = 3/100 (3%)

Query: 270  TEQLRHCSEILKEMLAK-KHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDN 328
            T+ +   S IL+ ++   +     +PF+ PV  NA  + +YY ++  PMDL T++E +  
Sbjct: 1400 TDPMVTLSSILESIINDMRDLPNTYPFHTPV--NAKVVKDYYKIITRPMDLQTLRENVRK 1457

Query: 329  QEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDV 368
            + Y    +F   + L+  N   YN P H +  +++ + D+
Sbjct: 1458 RLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDL 1497


>gi|91176325 bromodomain adjacent to zinc finger domain, 2A [Homo
            sapiens]
          Length = 1905

 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 35/103 (33%), Positives = 54/103 (52%), Gaps = 5/103 (4%)

Query: 273  LRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYK 332
            L  C  IL EM   +    AWPF  PV+   +    Y  ++KNPMD  T++E++    Y 
Sbjct: 1799 LTFCEIILMEM---ESHDAAWPFLEPVNPRLVS--GYRRIIKNPMDFSTMRERLLRGGYT 1853

Query: 333  DAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSK 375
             + +FAAD  L+F NC  +N  D EV     +++  FE+ + +
Sbjct: 1854 SSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEE 1896



 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 28/102 (27%), Positives = 51/102 (50%), Gaps = 2/102 (1%)

Query: 37   KVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIE 96
            +++L ++  H  +WPF  PV+   +    Y  IIKNPMD +T+++RL    Y  + E   
Sbjct: 1803 EIILMEMESHDAAWPFLEPVNPRLVS--GYRRIIKNPMDFSTMRERLLRGGYTSSEEFAA 1860

Query: 97   DFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQ 138
            D   +F NC  +N+   ++      + + F  +  +  Q +Q
Sbjct: 1861 DALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQ 1902



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 31/121 (25%), Positives = 63/121 (52%), Gaps = 6/121 (4%)

Query: 390 KTDITETTGRENTNEASSEGNSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKLN 449
           K  ITE   + + N    +  + +   +E   ++AK +++++   Q+ +  + +  +  N
Sbjct: 678 KVKITELLNKTD-NRPLKKLEAQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARN 736

Query: 450 KKKEKSKKEKKKE-KVNNSNENPRKMCEQMRLKEKSKRNQPKKRKQQFIGLKSEDEDNAK 508
           K+K+++K  K+KE K  +  E  +   +Q +LKEK KR + +K K +    + E+   AK
Sbjct: 737 KRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMK----EKEEVTKAK 792

Query: 509 P 509
           P
Sbjct: 793 P 793



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 29/119 (24%), Positives = 50/119 (42%), Gaps = 13/119 (10%)

Query: 822 SDELFNQFRKAAIEKEVKARTQEL------------IRKHLEQNTKELKASQENQRDLGN 869
           + E  N+  KA I K  K   Q++             R   +Q TK LK  +  ++    
Sbjct: 698 AQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAE 757

Query: 870 GLTVESFSNKIQNKCSGEE-QKEHQQSSEAQDKSKLWLLKDRDLARQKEQERRRREAMV 927
               ++   K++ K   E+ +K   +  E   K+K     D+ LA Q+  E R+R+ M+
Sbjct: 758 KEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMI 816


>gi|30794372 polybromo 1 isoform 1 [Homo sapiens]
          Length = 1602

 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 28/78 (35%), Positives = 45/78 (57%)

Query: 60  KLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMA 119
           K+Q PDYY IIK P+DL TI +R++N  Y       +D + +  N   YN+PG  +   A
Sbjct: 214 KVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDA 273

Query: 120 QALEKLFMQKLSQMPQEE 137
            +++K+F  K +++   E
Sbjct: 274 NSIKKIFYMKKAEIEHHE 291



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 75/349 (21%), Positives = 129/349 (36%), Gaps = 47/349 (13%)

Query: 60  KLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMA 119
           K + PDYY  IK P+ L  I+ +L+N+ Y        D N MF N   YN P   I    
Sbjct: 382 KKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRV 441

Query: 120 QALEKLFMQKLSQMPQEEQVVGVKERI----------KKGTQQNI----------AVSSA 159
             L+++   K  ++ + + +      I          K+ +++NI           V  A
Sbjct: 442 LKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEA 501

Query: 160 KEKSSPSATEKVFKQQEIPSVFP---KTSISP--LNVVQGASVNSSSQTAAQVTKGVK-- 212
           +E  S      +F  +     +P   K  + P  L +++    N        + + +K  
Sbjct: 502 REPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLM 561

Query: 213 -RKADTTTPATSAV------------KASSEFSPTFTEKSVALPPIKENMPKNVLPDSQQ 259
            R A       S V            +   E  P   +  +A P +K +    + P   +
Sbjct: 562 FRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSK 621

Query: 260 QYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDL 319
               ++     ++L    E +K    K+    +  F      + L   +YY  +K PMD+
Sbjct: 622 YMTPMQ-----QKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELP--DYYLTIKKPMDM 674

Query: 320 GTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDV 368
             I+  M   +Y+D      D  +MF N   YN P+  +   A +L  V
Sbjct: 675 EKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKV 723



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 26/76 (34%), Positives = 38/76 (50%)

Query: 62  QLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQA 121
           +LPDYY  IK PMD+  I+  +    Y      +EDF  MF+N   YN+P   I   A  
Sbjct: 660 ELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALV 719

Query: 122 LEKLFMQKLSQMPQEE 137
           L K+ ++    +  +E
Sbjct: 720 LHKVLLETRRDLEGDE 735



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 75/374 (20%), Positives = 132/374 (35%), Gaps = 73/374 (19%)

Query: 64  PDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALE 123
           PDYY ++  P+DL  I+++L+ + Y   +    DF  +F+N   Y KP       A  L 
Sbjct: 82  PDYYEVVSQPIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLW 141

Query: 124 KLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQ--------- 174
            L+++  ++  Q+ +     E   +  Q N    +  E SSP+  +++ +Q         
Sbjct: 142 DLYLRTRNEFVQKGE--ADDEDDDEDGQDN--QGTVTEGSSPAYLKEILEQLLEAIVVAT 197

Query: 175 -----------QEIPSVFPKTSI-----SPLNV------VQGASVNSSSQTAAQVTKGVK 212
                      Q++PS             P+++      +Q  S  S    A  +    K
Sbjct: 198 NPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAK 257

Query: 213 RKADTTTPATSAVKASSEFSPTFTEKSVALPPIKENMPKNVLPDSQQ---QYNVVKTVKV 269
                  P +   K ++     F  K   +      M K+ L  S +   Q   +  + +
Sbjct: 258 NAKTYNEPGSQVFKDANSIKKIFYMKKAEIE--HHEMAKSSLRMSNKRAVQGGRLSAITM 315

Query: 270 TEQLRHCSEILKEMLAKKH-------------FSYAWPFYNPVDVNALGLHNYYDVVKNP 316
             Q    SE    + A ++                + PFY   D      +N   ++  P
Sbjct: 316 ALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEP 375

Query: 317 --------------------MDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDH 356
                               + L  I+ K+ NQEY+       D+ LMF N  +YN P+ 
Sbjct: 376 FYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNS 435

Query: 357 EVVTMARMLQDVFE 370
            +      LQ V +
Sbjct: 436 AIYKRVLKLQQVMQ 449



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 24/72 (33%), Positives = 39/72 (54%), Gaps = 2/72 (2%)

Query: 308 NYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQD 367
           +YY ++K P+DL TI +++ N  YK  +  A D+ L+  N   YN P  +V   A  ++ 
Sbjct: 219 DYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANSIKK 278

Query: 368 VFETHFSKIPIE 379
           +F  +  K  IE
Sbjct: 279 IF--YMKKAEIE 288



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 37/186 (19%), Positives = 74/186 (39%), Gaps = 3/186 (1%)

Query: 308 NYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQD 367
           +YY ++  PMDL  I+  + N +Y        D++LMF N   YN    +V   A +L+ 
Sbjct: 525 DYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEK 584

Query: 368 VFETHFSKI-PIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERVKRLAKL 426
           + +    ++ P+   + M    +K         + +   +      ++  +       K 
Sbjct: 585 LLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKR 644

Query: 427 QEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQ--MRLKEKS 484
             +L A+  +L   S++P   L  KK    ++ +   + N  ++   M E   M      
Sbjct: 645 GRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNAC 704

Query: 485 KRNQPK 490
             N+P+
Sbjct: 705 TYNEPE 710


>gi|209977097 tripartite motif-containing 66 [Homo sapiens]
          Length = 1216

 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 34/86 (39%), Positives = 47/86 (54%), Gaps = 6/86 (6%)

Query: 294  PFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQE---YKDAYKFAADVRLMFMNCYK 350
            PF+ PV   A    +YY ++K PMDL  I+ K+  ++   Y    +  +DVRLMF NC K
Sbjct: 1065 PFHEPVSPLA---RHYYQIIKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAK 1121

Query: 351  YNPPDHEVVTMARMLQDVFETHFSKI 376
            +N PD EV    R L+  FE    +I
Sbjct: 1122 FNYPDSEVAEAGRCLEVFFEGWLKEI 1147



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 35/106 (33%), Positives = 55/106 (51%), Gaps = 7/106 (6%)

Query: 36   QKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENK---YYAKAS 92
            +K+VL  L  ++ S PF  PV  +      YY IIK PMDL+ I+++L+ K   +Y    
Sbjct: 1051 EKLVLS-LCCNNLSLPFHEPVSPLARH---YYQIIKRPMDLSIIRRKLQKKDPAHYTTPE 1106

Query: 93   ECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQ 138
            E + D   MF NC  +N P  ++    + LE  F   L ++  E++
Sbjct: 1107 EVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWLKEIYPEKR 1152


>gi|24429572 TBP-associated factor RNA polymerase 1-like [Homo
            sapiens]
          Length = 1826

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 42/153 (27%), Positives = 71/153 (46%), Gaps = 6/153 (3%)

Query: 35   LQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASEC 94
            L  +V + +     SWPF  PV+  K  +PDYY +I NP+DL TI+K +    Y      
Sbjct: 1530 LDNIVTQKMMAVPDSWPFHHPVN--KKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESF 1587

Query: 95   IEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNI 154
            ++D N + +N   YN P       AQ +  +  Q +++   +E +  +++ I   T +  
Sbjct: 1588 LDDVNLILANSVKYNGPESQYTKTAQEIVNICYQTITE--YDEHLTQLEKDI--CTAKEA 1643

Query: 155  AVSSAKEKSSPSATEKVFKQQEIPSVFPKTSIS 187
            A+  A+ +S    T   +  Q        TS+S
Sbjct: 1644 ALEEAELESLDPMTPGPYTSQPPDMYDTNTSLS 1676



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 29/94 (30%), Positives = 53/94 (56%), Gaps = 4/94 (4%)

Query: 277  SEILKEMLAKKHFSY--AWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDA 334
            S IL  ++ +K  +   +WPF++PV  N   + +YY ++ NP+DL TI++ +   +Y+  
Sbjct: 1527 SFILDNIVTQKMMAVPDSWPFHHPV--NKKFVPDYYKMIVNPVDLETIRKNISKHKYQSR 1584

Query: 335  YKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDV 368
              F  DV L+  N  KYN P+ +    A+ + ++
Sbjct: 1585 ESFLDDVNLILANSVKYNGPESQYTKTAQEIVNI 1618



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 30/115 (26%), Positives = 58/115 (50%), Gaps = 4/115 (3%)

Query: 32   LQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKA 91
            L  + + ++ D+     + PF  PV+A  ++  DYY II  PMDL T+++ +    Y   
Sbjct: 1404 LSSILESIINDMRDLPNTHPFHTPVNAKVVK--DYYKIITRPMDLQTLRENVRKCLYPSR 1461

Query: 92   SECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQVVGVKERI 146
             E  E    +  N   YN P   +  ++Q++  L  +KL +  +E+++  +++ I
Sbjct: 1462 EEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKE--KEDKLARLEKAI 1514



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 23/75 (30%), Positives = 40/75 (53%), Gaps = 2/75 (2%)

Query: 294  PFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNP 353
            PF+ PV  NA  + +YY ++  PMDL T++E +    Y    +F   + L+  N   YN 
Sbjct: 1423 PFHTPV--NAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNG 1480

Query: 354  PDHEVVTMARMLQDV 368
            P H +  +++ + D+
Sbjct: 1481 PKHSLTQISQSMLDL 1495


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.125    0.342 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,559,154
Number of Sequences: 37866
Number of extensions: 1660637
Number of successful extensions: 21549
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 324
Number of HSP's successfully gapped in prelim test: 880
Number of HSP's that attempted gapping in prelim test: 11052
Number of HSP's gapped (non-prelim): 6698
length of query: 947
length of database: 18,247,518
effective HSP length: 112
effective length of query: 835
effective length of database: 14,006,526
effective search space: 11695449210
effective search space used: 11695449210
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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