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Search of human proteins with 45597175
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45597175 TBC1 domain family, member 9B (with GRAM domain)
isoform a [Homo sapiens]
(1250 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso... 2503 0.0
gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso... 2457 0.0
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 1539 0.0
gi|156231067 TBC1 domain family, member 8 [Homo sapiens] 1090 0.0
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso... 1066 0.0
gi|38570103 TBC1 domain family, member 8B (with GRAM domain) iso... 674 0.0
gi|29648315 small G protein signaling modulator 3 [Homo sapiens] 164 4e-40
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 152 2e-36
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 139 2e-32
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 138 4e-32
gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 132 2e-30
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 127 7e-29
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 127 9e-29
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 115 3e-25
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 114 4e-25
gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 113 1e-24
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 111 4e-24
gi|68299759 ecotropic viral integration site 5 [Homo sapiens] 108 3e-23
gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 105 2e-22
gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 105 2e-22
gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 105 2e-22
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 105 2e-22
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 102 3e-21
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 102 3e-21
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 97 1e-19
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 91 9e-18
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 77 1e-13
gi|14149985 TBC1 domain family, member 3F [Homo sapiens] 73 2e-12
gi|149999613 TBC1 domain family, member 3B [Homo sapiens] 72 3e-12
gi|226693407 TBC1 domain family, member 3H [Homo sapiens] 72 3e-12
>gi|45597175 TBC1 domain family, member 9B (with GRAM domain) isoform
a [Homo sapiens]
Length = 1250
Score = 2503 bits (6486), Expect = 0.0
Identities = 1250/1250 (100%), Positives = 1250/1250 (100%)
Query: 1 MWLSPEEVLVANALWVTERANPFFVLQRRRGHGRGGGLTGLLVGTLDVVLDSSARVAPYR 60
MWLSPEEVLVANALWVTERANPFFVLQRRRGHGRGGGLTGLLVGTLDVVLDSSARVAPYR
Sbjct: 1 MWLSPEEVLVANALWVTERANPFFVLQRRRGHGRGGGLTGLLVGTLDVVLDSSARVAPYR 60
Query: 61 ILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIHGIIA 120
ILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIHGIIA
Sbjct: 61 ILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIHGIIA 120
Query: 121 EENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLYLTVN 180
EENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLYLTVN
Sbjct: 121 EENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLYLTVN 180
Query: 181 HLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGETFKL 240
HLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGETFKL
Sbjct: 181 HLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGETFKL 240
Query: 241 MEQLANLAMRQLLDSEGFLEDKALPRPIRPHRNISALKRDLDARAKNECYRATFRLPRDE 300
MEQLANLAMRQLLDSEGFLEDKALPRPIRPHRNISALKRDLDARAKNECYRATFRLPRDE
Sbjct: 241 MEQLANLAMRQLLDSEGFLEDKALPRPIRPHRNISALKRDLDARAKNECYRATFRLPRDE 300
Query: 301 RLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKADSSSV 360
RLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKADSSSV
Sbjct: 301 RLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKADSSSV 360
Query: 361 LPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIGSRKASVVDPSTESS 420
LPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIGSRKASVVDPSTESS
Sbjct: 361 LPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIGSRKASVVDPSTESS 420
Query: 421 PAPQEGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEKMKEE 480
PAPQEGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEKMKEE
Sbjct: 421 PAPQEGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEKMKEE 480
Query: 481 SWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVE 540
SWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVE
Sbjct: 481 SWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVE 540
Query: 541 KSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVT 600
KSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVT
Sbjct: 541 KSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVT 600
Query: 601 SVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDL 660
SVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDL
Sbjct: 601 SVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDL 660
Query: 661 GVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDE 720
GVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDE
Sbjct: 661 GVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDE 720
Query: 721 GEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAE 780
GEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAE
Sbjct: 721 GEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAE 780
Query: 781 DIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLASQYWGCS 840
DIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLASQYWGCS
Sbjct: 781 DIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLASQYWGCS 840
Query: 841 RTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSHTPLLAGRMFRLLDENKDSLIN 900
RTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSHTPLLAGRMFRLLDENKDSLIN
Sbjct: 841 RTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSHTPLLAGRMFRLLDENKDSLIN 900
Query: 901 FKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTEDSSSEASPLAS 960
FKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTEDSSSEASPLAS
Sbjct: 901 FKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTEDSSSEASPLAS 960
Query: 961 DLDLFLPWEAQEALPQEEQEGSGSEERGEEKGTSSPDYRHYLRMWAKEKEAQKETIKDLP 1020
DLDLFLPWEAQEALPQEEQEGSGSEERGEEKGTSSPDYRHYLRMWAKEKEAQKETIKDLP
Sbjct: 961 DLDLFLPWEAQEALPQEEQEGSGSEERGEEKGTSSPDYRHYLRMWAKEKEAQKETIKDLP 1020
Query: 1021 KMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKFSARTGRKPRDCA 1080
KMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKFSARTGRKPRDCA
Sbjct: 1021 KMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKFSARTGRKPRDCA 1080
Query: 1081 TEEDEPPAPELHQDAARELQPPAAGDPQAKAGGDTHLGKAPQESQVVVEGGSGEGQGSPS 1140
TEEDEPPAPELHQDAARELQPPAAGDPQAKAGGDTHLGKAPQESQVVVEGGSGEGQGSPS
Sbjct: 1081 TEEDEPPAPELHQDAARELQPPAAGDPQAKAGGDTHLGKAPQESQVVVEGGSGEGQGSPS 1140
Query: 1141 QLLSDDETKDDMSMSSYSVVSTGSLQCEDLADDTVLVGGEACSPTARIGGTVDTDWCISF 1200
QLLSDDETKDDMSMSSYSVVSTGSLQCEDLADDTVLVGGEACSPTARIGGTVDTDWCISF
Sbjct: 1141 QLLSDDETKDDMSMSSYSVVSTGSLQCEDLADDTVLVGGEACSPTARIGGTVDTDWCISF 1200
Query: 1201 EQILASILTESVLVNFFEKRVDIGLKIKDQKKVERQFSTASDHEQPGVSG 1250
EQILASILTESVLVNFFEKRVDIGLKIKDQKKVERQFSTASDHEQPGVSG
Sbjct: 1201 EQILASILTESVLVNFFEKRVDIGLKIKDQKKVERQFSTASDHEQPGVSG 1250
>gi|45597177 TBC1 domain family, member 9B (with GRAM domain) isoform
b [Homo sapiens]
Length = 1233
Score = 2457 bits (6369), Expect = 0.0
Identities = 1233/1250 (98%), Positives = 1233/1250 (98%), Gaps = 17/1250 (1%)
Query: 1 MWLSPEEVLVANALWVTERANPFFVLQRRRGHGRGGGLTGLLVGTLDVVLDSSARVAPYR 60
MWLSPEEVLVANALWVTERANPFFVLQRRRGHGRGGGLTGLLVGTLDVVLDSSARVAPYR
Sbjct: 1 MWLSPEEVLVANALWVTERANPFFVLQRRRGHGRGGGLTGLLVGTLDVVLDSSARVAPYR 60
Query: 61 ILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIHGIIA 120
ILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIHGIIA
Sbjct: 61 ILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIHGIIA 120
Query: 121 EENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLYLTVN 180
EENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLYLTVN
Sbjct: 121 EENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLYLTVN 180
Query: 181 HLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGETFKL 240
HLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGETFKL
Sbjct: 181 HLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGETFKL 240
Query: 241 MEQLANLAMRQLLDSEGFLEDKALPRPIRPHRNISALKRDLDARAKNECYRATFRLPRDE 300
MEQLANLAMRQLLDSEGFLEDKALPRPIRPHRNISALKRDLDARAKNECYRATFRLPRDE
Sbjct: 241 MEQLANLAMRQLLDSEGFLEDKALPRPIRPHRNISALKRDLDARAKNECYRATFRLPRDE 300
Query: 301 RLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKADSSSV 360
RLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKADSSSV
Sbjct: 301 RLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKADSSSV 360
Query: 361 LPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIGSRKASVVDPSTESS 420
LPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIGSRKASVVDPSTESS
Sbjct: 361 LPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIGSRKASVVDPSTESS 420
Query: 421 PAPQEGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEKMKEE 480
PAPQEGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEKMKEE
Sbjct: 421 PAPQEGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEKMKEE 480
Query: 481 SWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVE 540
SWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVE
Sbjct: 481 SWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVE 540
Query: 541 KSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVT 600
KSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVT
Sbjct: 541 KSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVT 600
Query: 601 SVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDL 660
SVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDL
Sbjct: 601 SVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDL 660
Query: 661 GVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDE 720
GVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDE
Sbjct: 661 GVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDE 720
Query: 721 GEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAE 780
GEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAE
Sbjct: 721 GEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAE 780
Query: 781 DIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLASQYWGCS 840
DIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLASQYWGCS
Sbjct: 781 DIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLASQYWGCS 840
Query: 841 RTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSHTPLLAGRMFRLLDENKDSLIN 900
RTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSHTPLLAGRMFRLLDENKDSLIN
Sbjct: 841 RTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSHTPLLAGRMFRLLDENKDSLIN 900
Query: 901 FKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTEDSSSEASPLAS 960
FKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTEDSSSE
Sbjct: 901 FKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTEDSSSE------ 954
Query: 961 DLDLFLPWEAQEALPQEEQEGSGSEERGEEKGTSSPDYRHYLRMWAKEKEAQKETIKDLP 1020
EALPQEEQEGSGSEERGEEKGTSSPDYRHYLRMWAKEKEAQKETIKDLP
Sbjct: 955 -----------EALPQEEQEGSGSEERGEEKGTSSPDYRHYLRMWAKEKEAQKETIKDLP 1003
Query: 1021 KMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKFSARTGRKPRDCA 1080
KMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKFSARTGRKPRDCA
Sbjct: 1004 KMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKFSARTGRKPRDCA 1063
Query: 1081 TEEDEPPAPELHQDAARELQPPAAGDPQAKAGGDTHLGKAPQESQVVVEGGSGEGQGSPS 1140
TEEDEPPAPELHQDAARELQPPAAGDPQAKAGGDTHLGKAPQESQVVVEGGSGEGQGSPS
Sbjct: 1064 TEEDEPPAPELHQDAARELQPPAAGDPQAKAGGDTHLGKAPQESQVVVEGGSGEGQGSPS 1123
Query: 1141 QLLSDDETKDDMSMSSYSVVSTGSLQCEDLADDTVLVGGEACSPTARIGGTVDTDWCISF 1200
QLLSDDETKDDMSMSSYSVVSTGSLQCEDLADDTVLVGGEACSPTARIGGTVDTDWCISF
Sbjct: 1124 QLLSDDETKDDMSMSSYSVVSTGSLQCEDLADDTVLVGGEACSPTARIGGTVDTDWCISF 1183
Query: 1201 EQILASILTESVLVNFFEKRVDIGLKIKDQKKVERQFSTASDHEQPGVSG 1250
EQILASILTESVLVNFFEKRVDIGLKIKDQKKVERQFSTASDHEQPGVSG
Sbjct: 1184 EQILASILTESVLVNFFEKRVDIGLKIKDQKKVERQFSTASDHEQPGVSG 1233
>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
sapiens]
Length = 1266
Score = 1539 bits (3984), Expect = 0.0
Identities = 801/1282 (62%), Positives = 960/1282 (74%), Gaps = 48/1282 (3%)
Query: 1 MWLSPEEVLVANALWVTERANPFFVLQRRRGH----GRGGGLTGLLVGTLDVVLDSSARV 56
MW++PEEVL+ANALW+TERANP+F+LQRR+GH G GGGL GLLVGTLDVVLDSSARV
Sbjct: 1 MWVNPEEVLLANALWITERANPYFILQRRKGHAGDGGGGGGLAGLLVGTLDVVLDSSARV 60
Query: 57 APYRILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIH 116
APYRIL+QT DS VYWT+ACG SRKEIT+HWEWLE NLLQTLSIF++E DITTFV+GKI
Sbjct: 61 APYRILYQTPDSLVYWTIACGGSRKEITEHWEWLEQNLLQTLSIFENENDITTFVRGKIQ 120
Query: 117 GIIAEENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLY 176
GIIAE NK + D+D KFKEA +K + FGMPE EKLVNYYSCSYWKG+VPRQGW+Y
Sbjct: 121 GIIAEYNKINDVKEDDDTEKFKEAIVKFHRLFGMPEEEKLVNYYSCSYWKGKVPRQGWMY 180
Query: 177 LTVNHLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGE 236
L++NHLCFYSFL+G+E LV++WVDIT+LEKNATLL P+ I+V TR E FFS+FLNI E
Sbjct: 181 LSINHLCFYSFLMGREAKLVIRWVDITQLEKNATLLLPDVIKVSTRSSEHFFSVFLNINE 240
Query: 237 TFKLMEQLANLAMRQLLDSEGFLEDKALPRPIRPH-RNISALKRDLDARAKNECYRATFR 295
TFKLMEQLAN+AMRQLLD+EGF +D++LP+ R + +SALKRDLDARAK+E YRA FR
Sbjct: 241 TFKLMEQLANIAMRQLLDNEGFEQDRSLPKLKRKSPKKVSALKRDLDARAKSERYRALFR 300
Query: 296 LPRDERLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKA 355
LP+DE+LDGHT CTLWTPFNK+HI GQMF+S NYICF SKEE+ C LIIPLREVTIVEKA
Sbjct: 301 LPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVEKA 360
Query: 356 DSSSVLPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSK---QPGSIGSRKASV 412
DSSSVLPSPLSIST+++MTFLFANLKDRDFLVQRISDFLQ+T SK GS +S
Sbjct: 361 DSSSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSKIYSDKEFAGSYNSS- 419
Query: 413 VDPSTESSPAPQEGSEQPASPASPLSSRQSFC--AQEAPTASQGLLKLFQKNSPMEDLGA 470
D S P+ S S +S + F PTA+Q L+ ++++ SP E+
Sbjct: 420 -DDEVYSRPSSLVSSSPQRSTSSDADGERQFNLNGNSVPTATQTLMTMYRRRSP-EEFNP 477
Query: 471 KGAKEKMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVT 530
K AKE +KE++W IHF EYG+G+CMYRT KTR LVLKGIPES+RGELWLL SGA NE T
Sbjct: 478 KLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKAT 537
Query: 531 HPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTI 590
HPGYY +LVEKS GKY+LATEEIERDLHRS+PEHPAFQNE+GIAALRRVLTAYAFRNP I
Sbjct: 538 HPGYYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNI 597
Query: 591 GYCQAMNIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFL 650
GYCQAMNIVTSVLLLY EEEAFWLLVALCERMLPDYYNTRVVGALVDQG+FEEL RD++
Sbjct: 598 GYCQAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQGVFEELARDYV 657
Query: 651 PQLSEKMQDLGVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDAN 710
PQL + MQDLGVIS+ISLSWFLTLFLSVMPFESAVV+VDCFFYEGIKVI Q+ALAVLDAN
Sbjct: 658 PQLYDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDAN 717
Query: 711 MEQLLGCSDEGEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVS 770
+++LL C D+GEAMT+LGRYLD+V NK S PPIPHL +LLS +P EVDIF L++ S
Sbjct: 718 VDKLLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIRTS 777
Query: 771 YEKFSSLRAEDIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAK 830
YEKF ++RA+ IEQMRFKQRLKVIQ+LEDT KR+VVR I + F+I+ELE+LY +FKA+
Sbjct: 778 YEKFGTIRADLIEQMRFKQRLKVIQTLEDTTKRNVVRTIVTETSFTIDELEELYALFKAE 837
Query: 831 HLASQYWGCSRTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSHTPLLAGRMFRL 890
HL S YWG S R DPSLPYLEQYRID QF+ +FA L PWACG+H+ +LA R+F+L
Sbjct: 838 HLTSCYWGGSSNALDRHDPSLPYLEQYRIDFEQFKGMFALLFPWACGTHSDVLASRLFQL 897
Query: 891 LDENKDSLINFKEFVTGMSGMYHGDLTEKLKVLYKLHL--PPALSPEEAESALEAAHYFT 948
LDEN DSLINF+EFV+G+S HGDLTEKLK+LYK+H+ P+ +E +SA EA YF
Sbjct: 898 LDENGDSLINFREFVSGLSAACHGDLTEKLKLLYKMHVLPEPSSDQDEPDSAFEATQYFF 957
Query: 949 EDSSSEASPLASDLDLFLPWEAQEALPQEEQEGSGSEERGEEKGTSSPDYRHYLRMWAKE 1008
ED + E + + L +++ S ++G K +S + R+YLR+W E
Sbjct: 958 EDITPECTHVVG-----LDSRSKQGADDGFVTVSLKPDKG--KRANSQENRNYLRLWTPE 1010
Query: 1009 KEAQKETIKDLPKMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKF 1068
+++ + KDLPK+NQ QFIELCKT+YNMFSEDP EQ+LYHA A V SLLL IGEVGK F
Sbjct: 1011 NKSKSKNAKDLPKLNQGQFIELCKTMYNMFSEDPNEQELYHATAAVTSLLLEIGEVGKLF 1070
Query: 1069 SARTGRKPRDCATEEDEPPAPELHQDAARELQPPAAGD-----------PQAKAGGDTHL 1117
A+ ++ + P HQ L P P + A
Sbjct: 1071 VAQPAKEGGSGGS------GPSCHQGIPGVLFPKKGPGQPYVVESVEPLPASLAPDSEEH 1124
Query: 1118 GKAPQESQVVVEGGSGEGQGS-PSQLLSDDETKDDMSMSSYSVVSTGS-----LQCEDLA 1171
Q + +E S G+ S L+SDD+TKDD SMSSYSV+S GS L CED+
Sbjct: 1125 SLGGQMEDIKLEDSSPRDNGACSSMLISDDDTKDDSSMSSYSVLSAGSHEEDKLHCEDIG 1184
Query: 1172 DDTVLVGGEACSPTARIGGTVDTDWCISFEQILASILTESVLVNFFEKRVDIGLKIKDQK 1231
+DTVLV + ++D DW I+FEQ LAS+LTE LV +F+K V + +I K
Sbjct: 1185 EDTVLVRSGQGTAALPRSTSLDRDWAITFEQFLASLLTEPALVKYFDKPVCMMARITSAK 1244
Query: 1232 KVE---RQFSTASDHEQPGVSG 1250
+ + ++ASD+E +SG
Sbjct: 1245 NIRMMGKPLTSASDYEISAMSG 1266
>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
Length = 1140
Score = 1090 bits (2818), Expect = 0.0
Identities = 577/1160 (49%), Positives = 767/1160 (66%), Gaps = 70/1160 (6%)
Query: 1 MWLSPEEVLVANAL--WVTERANPFFVLQRRRGHGRGGG-LTGLLVGTLDVVLDSSARVA 57
MWL PEEVL+ NAL WVT++++ +F+LQRRRGHG GGG LTG LVG LD VLDS+ARVA
Sbjct: 1 MWLKPEEVLLKNALKLWVTQKSSCYFILQRRRGHGEGGGRLTGRLVGALDAVLDSNARVA 60
Query: 58 PYRILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIHG 117
P+RIL Q SQVY +ACG++ +EI +HW+WLE NLL TLS+FD+++DI +FVKGK+
Sbjct: 61 PFRILLQVPGSQVYSPIACGATLEEINQHWDWLEQNLLHTLSVFDNKDDIASFVKGKVKA 120
Query: 118 IIAEENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLYL 177
+IAEE + + +E+P KF+EA +K +F PE EKLV YYSC WKGRVPRQGWLYL
Sbjct: 121 LIAEETSSRLAEQEEEPEKFREALVKFEARFNFPEAEKLVTYYSCCCWKGRVPRQGWLYL 180
Query: 178 TVNHLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGET 237
++NHLCFYSF LGKE+ LVV WVDI +LE+ + + ++IR+ T+++E FSMFLN+ E
Sbjct: 181 SINHLCFYSFFLGKELKLVVPWVDIQKLERTSNVFLTDTIRITTQNKERDFSMFLNLDEV 240
Query: 238 FKLMEQLANLAMRQLLDSEGFLEDKALPRPIRPHRNISALKRDLDARAKNECYRATFRLP 297
FK+MEQLA++ +R+LLD+E F D L P + KRDL+ARA+NE +RA FRLP
Sbjct: 241 FKVMEQLADVTLRRLLDNEVFDLDPDLQEPSQ------ITKRDLEARAQNEFFRAFFRLP 294
Query: 298 RDERLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKADS 357
R E+L C+LWTPF++ H G+MF S++YICFAS+E+ C +I+PLREV +EK +
Sbjct: 295 RKEKLHAVVDCSLWTPFSRCHTTGRMFASDSYICFASREDGCCKIILPLREVVSIEKMED 354
Query: 358 SSVLPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQP----GSIGSRKASVV 413
+S+LP P+ +S +SK+ F F L+DRD LV+ + L++ + P S AS+V
Sbjct: 355 TSLLPHPIIVSIRSKVAFQFIELRDRDSLVEALLARLKQVHANHPVHYDTSADDDMASLV 414
Query: 414 DPSTESSPAPQEGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGA 473
ST + G + S + S + P A L+ FQ+ S + ++ +
Sbjct: 415 FHSTSMCSDHRFGDLEMMSSQNSEESEKEKSPLMHPDA---LVTAFQQ-SGSQSPDSRMS 470
Query: 474 KEKMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPG 533
+E++K W+ HF EYGR VCM+RT K R LV GIPESLRG LWLLFS A ++ +HPG
Sbjct: 471 REQIKISLWNDHFVEYGRTVCMFRTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPG 530
Query: 534 YYAELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYC 593
YY LVE+S GK L TEEIERDLHRS+PEHPAFQNE GIAALRRVLTAYA RNP IGYC
Sbjct: 531 YYGNLVEESLGKCCLVTEEIERDLHRSLPEHPAFQNETGIAALRRVLTAYAHRNPKIGYC 590
Query: 594 QAMNIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQL 653
Q+MNI+TSVLLLY EEEAFWLLVA+CERMLPDY+N RV+GA VDQ +FEEL + LP+L
Sbjct: 591 QSMNILTSVLLLYTKEEEAFWLLVAVCERMLPDYFNHRVIGAQVDQSVFEELIKGHLPEL 650
Query: 654 SEKMQDLGVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQ 713
+E M DL ++S+SLSWFLTLFLS+MP ESAV +VDCFFY+GIK I Q+ LAVL+AN E
Sbjct: 651 AEHMNDLSALASVSLSWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAED 710
Query: 714 LLGCSDEGEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEK 773
L D+G+A+ +L R+LD++ N+ S PP+ A S +P DI +L++ SYEK
Sbjct: 711 LCSSKDDGQALMILSRFLDHIKNEDSPGPPVGSHHAFFSDDQEPYPVTDISDLIRDSYEK 770
Query: 774 FSSLRAEDIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLA 833
F E IE +R+K R++V+Q EDT K++V+R + ++ E+LE+LY +FK +H+
Sbjct: 771 FGDQSVEQIEHLRYKHRIRVLQGHEDTTKQNVLRVVIPEVSILPEDLEELYDLFKREHMM 830
Query: 834 SQYWGCSRTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSHTPLLAGRMFRLLDE 893
S YW R MA R DPS PY EQYRIDA QF LF ++PW CG+HT +LA R FRLLD+
Sbjct: 831 SCYWEQPRPMASRHDPSRPYAEQYRIDARQFAHLFQLVSPWTCGAHTEILAERTFRLLDD 890
Query: 894 NKDSLINFKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTEDSSS 953
N D LI FK FV+ + MY+G++ EK+K+LY+LH+PPAL TE+
Sbjct: 891 NMDQLIEFKAFVSCLDIMYNGEMNEKIKLLYRLHIPPAL---------------TENDRD 935
Query: 954 EASPLASDLDLFLPWEAQEALPQEEQEGSGSEERGEEKGTSSPDYRHYLRMWAKEKEAQK 1013
SPL + L + P + +G + DY+ L+ K+ +K
Sbjct: 936 SQSPLRNPL-------LSTSRPLVFGKPNG----------DAVDYQKQLKQMIKDLAKEK 978
Query: 1014 E-TIKDLPKMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKFSART 1072
+ T K+LPKM+Q +FI+ CKTLY+MF EDP E DLY AIATV +LLL+IGEVG++
Sbjct: 979 DKTEKELPKMSQREFIQFCKTLYSMFHEDPEENDLYQAIATVTTLLLQIGEVGQR----- 1033
Query: 1073 GRKPRDCATEEDEPPAPELHQDAARELQPPAAGDPQAKAGGDTHLGKAPQESQVVVEGGS 1132
G C+ Q+ EL+ +A P+ DT GK PQ+SQ E
Sbjct: 1034 GSSSGSCS------------QECGEELR-ASAPSPEDSVFADT--GKTPQDSQAFPEAAE 1078
Query: 1133 GEGQGSPSQLLSDDETKDDM 1152
+ S +L+ T+ +
Sbjct: 1079 RDWTVSLEHILASLLTEQSL 1098
Score = 47.0 bits (110), Expect = 1e-04
Identities = 21/39 (53%), Positives = 29/39 (74%)
Query: 1193 DTDWCISFEQILASILTESVLVNFFEKRVDIGLKIKDQK 1231
+ DW +S E ILAS+LTE LVNFFEK +D+ K+++ K
Sbjct: 1078 ERDWTVSLEHILASLLTEQSLVNFFEKPLDMKSKLENAK 1116
>gi|38570101 TBC1 domain family, member 8B (with GRAM domain) isoform
a [Homo sapiens]
Length = 1120
Score = 1066 bits (2757), Expect = 0.0
Identities = 565/1076 (52%), Positives = 737/1076 (68%), Gaps = 43/1076 (3%)
Query: 1 MWLSPEEVLVANAL--WVTERANPFFVLQRRRGHGR--GGGLTGLLVGTLDVVLDSSARV 56
MWL PEEVL+ NAL W+ ER+N +FVLQRRRG+G GGGLTGLLVGTLD VLDS+A+V
Sbjct: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV 60
Query: 57 APYRILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIH 116
AP+RILHQT DSQVY ++ACG++R+EITKHW+WLE N+++TLS+FDS EDIT FV+GKI
Sbjct: 61 APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR 120
Query: 117 GIIAEENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLY 176
G+IAEE K+ + D DP KF+EA LK K FG+PE EKLV YYSCSYWKGRVP QGWLY
Sbjct: 121 GLIAEEGKHCFAKED-DPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLY 179
Query: 177 LTVNHLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGE 236
L+ N L FYSFLLG E+ L++ W ++++LEK + ++ ESI V ++ + +FSMFL+I +
Sbjct: 180 LSTNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQ 239
Query: 237 TFKLMEQLANLAMRQLLDSEGFLEDKALPRPIRPHRNISALKRDLDARAKNECYRATFRL 296
T+ LMEQLAN A+R+L D E F D L P++ KR L+ RA +E + A FRL
Sbjct: 240 TYLLMEQLANYAIRRLFDKETFDNDPVLYNPLQ------ITKRGLENRAHSEQFNAFFRL 293
Query: 297 PRDERLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKAD 356
P+ E L C LW PF+ + G+M IS NYICFAS++ + C +IIPLREV ++K +
Sbjct: 294 PKGESLKEVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTN 353
Query: 357 SSSVLPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIGSRKASVVDPS 416
SS + IS K K F F +KD + LV ++ G+ D S
Sbjct: 354 DSS---KSVIISIKGKTAFRFHEVKDFEQLVAKLRL-----------RCGAASTQYHDIS 399
Query: 417 TESSPAPQEGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEK 476
TE + + + L+S++ C++ T + L+ +F + +E L +K KEK
Sbjct: 400 TELAISSESTEPSDNFEVQSLTSQRE-CSKTVNT--EALMTVFHPQN-LETLNSKMLKEK 455
Query: 477 MKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYA 536
MKE+SW I F E GRGV M+RT KTR LV++GIPE+LRGELW+LFSGA N+M T+P YY
Sbjct: 456 MKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYT 515
Query: 537 ELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAM 596
E+VE+S G +LATEEIERDL RS+PEHPAFQ++ GI+ALRRVLTAYA+RNP IGYCQAM
Sbjct: 516 EVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAM 575
Query: 597 NIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEK 656
NI+TSVLLLY EEEAFWLLVA+CERMLPDY+N R++GALVDQ +FEEL RD LPQL+E
Sbjct: 576 NILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQLTEH 635
Query: 657 MQDLGVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLG 716
M D+ SS+SLSWFLTLF+SV+P ESAV +VDCFFY+GIK ILQ+ LA+LD N+++LL
Sbjct: 636 MTDMTFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLT 695
Query: 717 CSDEGEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSS 776
C D+ EA+T L R+ DNV NK S P + +S VDI +L++ S EK+ +
Sbjct: 696 CKDDAEAVTALNRFFDNVTNKDSPLPSNVQQGSNVSDEKTSHTRVDITDLIRESNEKYGN 755
Query: 777 LRAEDIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLASQY 836
+R EDI MR + RL VIQ+LE+T K++V+R + D+ S++EL++LY++FK + S Y
Sbjct: 756 IRYEDIHSMRCRNRLYVIQTLEETTKQNVLRVVSQDVKLSLQELDELYVIFKKELFLSCY 815
Query: 837 WGCSRTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSHTPLLAGRMFRLLDENKD 896
W + DPSLPYLEQY+ID QFR L+ L+PWA ++ LA FRLLDEN D
Sbjct: 816 WCLGCPVLKHHDPSLPYLEQYQIDCQQFRALYHLLSPWAHSANKDSLALWTFRLLDENSD 875
Query: 897 SLINFKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTEDSSSEAS 956
LINFKEF + + MY+G TEKLK+L+KLH+PPA + +++ A + ++ S E
Sbjct: 876 CLINFKEFSSAIDIMYNGSFTEKLKLLFKLHIPPAYTEVKSKDASKG-----DELSKEEL 930
Query: 957 PLASDLDLFLPWEAQEALPQEEQEGSGSEERGEEKGTSSPDYRHYLRMWAKEKEAQKETI 1016
S L + P +EA S + EKG D + YL W E ++E I
Sbjct: 931 LYFSQLHVSKPANEKEA---------ESAKHSPEKGKGKIDIQAYLSQWQDELFKKEENI 981
Query: 1017 KDLPKMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKFSART 1072
KDLP+MNQ QFI+ KTLYN+F EDP E+ LY AIA V SLLLR+ EVG+K + T
Sbjct: 982 KDLPRMNQSQFIQFSKTLYNLFHEDPEEESLYQAIAVVTSLLLRMEEVGRKLHSPT 1037
Score = 43.5 bits (101), Expect = 0.001
Identities = 18/39 (46%), Positives = 27/39 (69%)
Query: 1193 DTDWCISFEQILASILTESVLVNFFEKRVDIGLKIKDQK 1231
+ W +FEQILAS+L E LV FFEK +D+ K+++ +
Sbjct: 1072 EPQWSFAFEQILASLLNEPALVRFFEKPIDVKAKLENAR 1110
>gi|38570103 TBC1 domain family, member 8B (with GRAM domain)
isoform b [Homo sapiens]
Length = 632
Score = 674 bits (1740), Expect = 0.0
Identities = 353/639 (55%), Positives = 455/639 (71%), Gaps = 29/639 (4%)
Query: 1 MWLSPEEVLVANAL--WVTERANPFFVLQRRRGHGR--GGGLTGLLVGTLDVVLDSSARV 56
MWL PEEVL+ NAL W+ ER+N +FVLQRRRG+G GGGLTGLLVGTLD VLDS+A+V
Sbjct: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV 60
Query: 57 APYRILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIH 116
AP+RILHQT DSQVY ++ACG++R+EITKHW+WLE N+++TLS+FDS EDIT FV+GKI
Sbjct: 61 APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR 120
Query: 117 GIIAEENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLY 176
G+IAEE K+ + D DP KF+EA LK K FG+PE EKLV YYSCSYWKGRVP QGWLY
Sbjct: 121 GLIAEEGKHCFAKED-DPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLY 179
Query: 177 LTVNHLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGE 236
L+ N L FYSFLLG E+ L++ W ++++LEK + ++ ESI V ++ + +FSMFL+I +
Sbjct: 180 LSTNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQ 239
Query: 237 TFKLMEQLANLAMRQLLDSEGFLEDKALPRPIRPHRNISALKRDLDARAKNECYRATFRL 296
T+ LMEQLAN A+R+L D E F D L P++ KR L+ RA +E + A FRL
Sbjct: 240 TYLLMEQLANYAIRRLFDKETFDNDPVLYNPLQ------ITKRGLENRAHSEQFNAFFRL 293
Query: 297 PRDERLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKAD 356
P+ E L C LW PF+ + G+M IS NYICFAS++ + C +IIPLREV ++K +
Sbjct: 294 PKGESLKEVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTN 353
Query: 357 SSSVLPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIGSRKASVVDPS 416
SS + IS K K F F +KD + LV ++ G+ D S
Sbjct: 354 DSS---KSVIISIKGKTAFRFHEVKDFEQLVAKLRL-----------RCGAASTQYHDIS 399
Query: 417 TESSPAPQEGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEK 476
TE + + + L+S++ C++ T + L+ +F + +E L +K KEK
Sbjct: 400 TELAISSESTEPSDNFEVQSLTSQRE-CSKTVNT--EALMTVFHPQN-LETLNSKMLKEK 455
Query: 477 MKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYA 536
MKE+SW I F E GRGV M+RT KTR LV++GIPE+LRGELW+LFSGA N+M T+P YY
Sbjct: 456 MKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYT 515
Query: 537 ELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAM 596
E+VE+S G +LATEEIERDL RS+PEHPAFQ++ GI+ALRRVLTAYA+RNP IGYCQAM
Sbjct: 516 EVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAM 575
Query: 597 NIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGA 635
NI+TSVLLLY EEEAFWLLVA+CERMLPDY+N R++G+
Sbjct: 576 NILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGS 614
>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
Length = 749
Score = 164 bits (416), Expect = 4e-40
Identities = 89/227 (39%), Positives = 140/227 (61%), Gaps = 4/227 (1%)
Query: 493 VCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEE 552
V + R+ K R+LVL GIP +R +LW+ SGA + Y E+V+ S+ ++A ++
Sbjct: 99 VSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQ 158
Query: 553 IERDLHRSMPEHPAFQN--ELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEE 610
IE+DL R+MP + F + +G+ LRRVL A A+ P IGYCQ +V + LLL+ EE
Sbjct: 159 IEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEE 218
Query: 611 EAFWLLVALCERMLP-DYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGV-ISSISL 668
+AFW++ A+ E +LP Y++T ++G DQ + L +LP+L + +Q+ + +S I+L
Sbjct: 219 DAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITL 278
Query: 669 SWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLL 715
WFLT F SV+ + + I D FFYEG +V+ Q+ L +L E+L+
Sbjct: 279 HWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELI 325
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 152 bits (384), Expect = 2e-36
Identities = 90/232 (38%), Positives = 135/232 (58%), Gaps = 11/232 (4%)
Query: 490 GRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLA 549
G GV RT K V KG+P R +W++ SGA +M +PGYY +L++ G+ +
Sbjct: 52 GGGVPRSRTVKR--YVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQ---GERNPR 106
Query: 550 TEE-IERDLHRSMPEHPAFQNELGIAALR---RVLTAYAFRNPTIGYCQAMNIVTSVLLL 605
E+ I DL+R+ P++ F+ R VL AY N +GYCQ MN + L+L
Sbjct: 107 LEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLIL 166
Query: 606 Y-GSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVIS 664
+EEE+FWLL AL R+LPDYY+ ++G DQ + EL R LP + M+ LGV+
Sbjct: 167 ITNNEEESFWLLDALVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLW 226
Query: 665 SISLS-WFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLL 715
++ +S WF+ LF+ ++P E+ + I DC F EG K+I +VAL ++ + E +L
Sbjct: 227 TLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELIL 278
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 139 bits (350), Expect = 2e-32
Identities = 84/252 (33%), Positives = 137/252 (54%), Gaps = 7/252 (2%)
Query: 495 MYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMV---THPGYYAELVEKSTGKYSLATE 551
M + + + L+ GIP R ++W T PG++ L++K+ K + A++
Sbjct: 649 MMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASK 708
Query: 552 EIERDLHRSMP--EHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSE 609
+IE DL R++P +H + GI LR VL A+++RNP IGYCQ +N + +V LLY +
Sbjct: 709 QIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQ 768
Query: 610 EEAFWLLVALCERMLP-DYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGV-ISSIS 667
E+AFW LV + E +P DYY ++G+ VDQ +F +L + LP+L + V + I+
Sbjct: 769 EDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLIT 828
Query: 668 LSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEGEAMTML 727
+WFL +F+ + + I D F YEG KVI + ALA+ E++L D L
Sbjct: 829 FNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYL 888
Query: 728 GRYLDNVVNKQS 739
+ +++ +S
Sbjct: 889 RYFTRTILDARS 900
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 138 bits (347), Expect = 4e-32
Identities = 82/232 (35%), Positives = 130/232 (56%), Gaps = 7/232 (3%)
Query: 495 MYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMV---THPGYYAELVEKSTGKYSLATE 551
M + + + L+ GIP R ++W T PG++ L++K+ K + A++
Sbjct: 649 MMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASK 708
Query: 552 EIERDLHRSMP--EHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSE 609
+IE DL R++P +H + GI LR VL A+++RNP IGYCQ +N + +V LLY +
Sbjct: 709 QIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQ 768
Query: 610 EEAFWLLVALCERMLP-DYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGV-ISSIS 667
E+AFW LV + E +P DYY ++G+ VDQ +F +L + LP+L + V + I+
Sbjct: 769 EDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLIT 828
Query: 668 LSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSD 719
+WFL +F+ + + I D F YEG KVI + ALA+ E++L D
Sbjct: 829 FNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQD 880
>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
Length = 446
Score = 132 bits (332), Expect = 2e-30
Identities = 83/235 (35%), Positives = 113/235 (48%), Gaps = 6/235 (2%)
Query: 476 KMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYY 535
+ +E W + + R K + KGIP +LR W L GA PG Y
Sbjct: 61 RQREMKW-VEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTY 119
Query: 536 AELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIA--ALRRVLTAYAFRNPTIGYC 593
EL E + T I RDLHR P H F + G L +VL AY P GYC
Sbjct: 120 QELAEAPGDPQWMET--IGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYC 177
Query: 594 QAMNIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQL 653
QA V +VLL++ EEAFW LV +CE LP YY + +D +F L R LP +
Sbjct: 178 QAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHV 237
Query: 654 SEKMQDLGVISSISL-SWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVL 707
+ +Q +GV + L WFL LF +PF + + + D F EG +V+ +V L ++
Sbjct: 238 HKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLV 292
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 127 bits (319), Expect = 7e-29
Identities = 84/258 (32%), Positives = 130/258 (50%), Gaps = 9/258 (3%)
Query: 476 KMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYY 535
+ +E W F + + + R K + KGIP SLR + W S + + +PG +
Sbjct: 329 RQRELKWLDMFSNWDKWLSR-RFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKF 387
Query: 536 AELVEKSTGKYSLATEEIERDLHRSMPEHPAF--QNELGIAALRRVLTAYAFRNPTIGYC 593
EL E++ G + IE+DLHR P H F + G L R+L AY P GYC
Sbjct: 388 EEL-ERAPGDPKWL-DVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYC 445
Query: 594 QAMNIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQL 653
QA V +VLL++ E+AFW LV +C++ LP YY+ + +D IF L R P
Sbjct: 446 QAQAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLA 505
Query: 654 SEKMQDLGVISSISLS-WFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLD---A 709
++ + + ++ WF+ +F +P+ S + + D FF EG+K+I +VAL +L
Sbjct: 506 HRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLG 565
Query: 710 NMEQLLGCSDEGEAMTML 727
++E+L C E M L
Sbjct: 566 SVEKLRSCQGMYETMEQL 583
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 127 bits (318), Expect = 9e-29
Identities = 92/286 (32%), Positives = 143/286 (50%), Gaps = 20/286 (6%)
Query: 469 GAKGAKEKM-------KEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLF 521
GA+GA E++ +E W + + + + K R KGIP SLRG W
Sbjct: 66 GAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAK-KHKKIRLRCQKGIPPSLRGRAWQYL 124
Query: 522 SGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAA--LRRV 579
SG ++ +PG + EL + S G + IERDLHR P H F + G L RV
Sbjct: 125 SGGKVKLQQNPGKFDEL-DMSPGDPKWL-DVIERDLHRQFPFHEMFVSRGGHGQQDLFRV 182
Query: 580 LTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQ 639
L AY P GYCQA + +VLL++ E+AFW LV +CE+ LP YY+ ++ +D
Sbjct: 183 LKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDG 242
Query: 640 GIFEELTRDFLPQLSEKMQDLGVISSISLS-WFLTLFLSVMPFESAVVIVDCFFYEGIKV 698
I L + P + + + + ++ WF+ F +P+ S + + D FF EG+K+
Sbjct: 243 EILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKI 302
Query: 699 ILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVVNKQSVSPPI 744
I +V L +L + LG ++ +A G+Y + + +S+SP I
Sbjct: 303 IFRVGLVLL----KHALGSPEKVKACQ--GQY-ETIERLRSLSPKI 341
>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
sapiens]
Length = 794
Score = 115 bits (288), Expect = 3e-25
Identities = 97/326 (29%), Positives = 157/326 (48%), Gaps = 27/326 (8%)
Query: 502 RALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSM 561
+ L+ KGIP R +W L A + V + Y+EL++ S+ L I RD+ R+
Sbjct: 109 KELIRKGIPHHFRAIVWQLLCSATDMPVKNQ--YSELLKMSSPCEKL----IRRDIARTY 162
Query: 562 PEHPAF--QNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVAL 619
PEH F Q+ LG L V+ AY+ + +GYCQ + +LL+ EEEAF + V L
Sbjct: 163 PEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRL 222
Query: 620 C-ERMLPDYYNTRV--VGALVDQGIFEELTRDFLPQLSEKMQDLGVISSI-SLSWFLTLF 675
E L + + + +G + Q FE + ++ LP L+ + +S+ + SWFLTLF
Sbjct: 223 MQEYRLRELFKPSMAELGLCIYQ--FEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLF 280
Query: 676 LSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVV 735
L+ P A + D F YEG++++ +V LA+L N +L+ EG + +Y V+
Sbjct: 281 LTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEG-----MSQYFQRVI 335
Query: 736 NKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAE---DIEQMRFKQRLK 792
Q S P + +P + L+ Y S E +I+++R + RL
Sbjct: 336 PHQFDSCPDKLVLKAYQVKYNPKK----MKRLEKEYAAMKSKEMEEQIEIKRLRTENRL- 390
Query: 793 VIQSLEDTAKRSVVRAIPVDIGFSIE 818
+ Q +E K V RA + + I+
Sbjct: 391 LKQRIETLEKGQVTRAQEAEENYVIK 416
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 114 bits (286), Expect = 4e-25
Identities = 69/205 (33%), Positives = 111/205 (54%), Gaps = 5/205 (2%)
Query: 498 TAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDL 557
+A+ + L+ G+P R +W + + PG Y EL+ + + A +IE DL
Sbjct: 615 SAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDL 674
Query: 558 HRSMPEHPAFQNELGIAA--LRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEE-AFW 614
+R+ P + F LRRVL A++++NPTIGYCQ +N + ++ LL EEE AFW
Sbjct: 675 NRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFW 734
Query: 615 LLVALCERMLP-DYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGV-ISSISLSWFL 672
LVA+ E ++P DYY + + VDQ + ++L + LP+L + V +S ++ +WFL
Sbjct: 735 CLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFL 794
Query: 673 TLFLSVMPFESAVVIVDCFFYEGIK 697
+F + + + D F YEG K
Sbjct: 795 VVFADSLISNILLRVWDAFLYEGTK 819
>gi|229577000 ecotropic viral integration site 5-like isoform 1
[Homo sapiens]
Length = 805
Score = 113 bits (282), Expect = 1e-24
Identities = 95/316 (30%), Positives = 152/316 (48%), Gaps = 27/316 (8%)
Query: 502 RALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSM 561
+ L+ KGIP R +W L A + V + Y+EL++ S+ L I RD+ R+
Sbjct: 109 KELIRKGIPHHFRAIVWQLLCSATDMPVKNQ--YSELLKMSSPCEKL----IRRDIARTY 162
Query: 562 PEHPAF--QNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVAL 619
PEH F Q+ LG L V+ AY+ + +GYCQ + +LL+ EEEAF + V L
Sbjct: 163 PEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRL 222
Query: 620 C-ERMLPDYYNTRV--VGALVDQGIFEELTRDFLPQLSEKMQDLGVISSI-SLSWFLTLF 675
E L + + + +G + Q FE + ++ LP L+ + +S+ + SWFLTLF
Sbjct: 223 MQEYRLRELFKPSMAELGLCIYQ--FEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLF 280
Query: 676 LSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVV 735
L+ P A + D F YEG++++ +V LA+L N +L+ EG + +Y V+
Sbjct: 281 LTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEG-----MSQYFQRVI 335
Query: 736 NKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAE---DIEQMRFKQRLK 792
Q S P + +P + L+ Y S E +I+++R + RL
Sbjct: 336 PHQFDSCPDKLVLKAYQVKYNPKK----MKRLEKEYAAMKSKEMEEQIEIKRLRTENRL- 390
Query: 793 VIQSLEDTAKRSVVRA 808
+ Q +E K S A
Sbjct: 391 LKQRIETLEKESAALA 406
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 111 bits (278), Expect = 4e-24
Identities = 90/305 (29%), Positives = 142/305 (46%), Gaps = 24/305 (7%)
Query: 424 QEGSEQPASPAS---PLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEKMKEE 480
+ E+P +P S P+S + +E+ K+ P + L + G E + +
Sbjct: 463 ESDKEEPVTPTSGGGPMSPQDDEAEEESDNELSSGTGDVSKDCPEKILYSWG--ELLGK- 519
Query: 481 SWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVE 540
WH + +G+ LV G+PE+LR E+W L +G + Y L+
Sbjct: 520 -WHSNLGARPKGLS--------TLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRI-LIT 569
Query: 541 KSTGKYSLATEEIERDLHRSMPEHPAFQNELGIA--ALRRVLTAYAFRNPTIGYCQAMNI 598
K + + S+ T RD+HR+ P H F++ G +L ++ AY+ + IGYCQ +
Sbjct: 570 KDSAQESVIT----RDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSF 625
Query: 599 VTSVLLLYGSEEEAFWLLVALC-ERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKM 657
+ +VLLL+ EE+AF +LV + + L D Y E L ++ LP L
Sbjct: 626 LAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHF 685
Query: 658 QDLGVISSISLS-WFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLG 716
DL + + + S WFLTLF + P I+D EG+ +I VALA+L + E LL
Sbjct: 686 SDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQ 745
Query: 717 CSDEG 721
EG
Sbjct: 746 ADFEG 750
>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
Length = 810
Score = 108 bits (270), Expect = 3e-23
Identities = 103/385 (26%), Positives = 171/385 (44%), Gaps = 48/385 (12%)
Query: 371 SKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIG---SRKAS-VVDPSTE--SSPAPQ 424
+KMT F N + ++++ L T S ++ S+ AS V PST ++ +
Sbjct: 4 NKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTSSST 63
Query: 425 EGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPME------------------ 466
S SP+SP +Q +P + L KL ++N +E
Sbjct: 64 TLSTPALSPSSP--------SQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGS 115
Query: 467 ----DLGAKGAKEKMKEESWHI--HFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLL 520
A ++E+SW + V + + + LV KGIP R +W L
Sbjct: 116 SLVSSSSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQL 175
Query: 521 FSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNE--LGIAALRR 578
A + + Y+EL++ ++ L I RD+ R+ PEH F+ + LG L
Sbjct: 176 LCSAQSMPIKDQ--YSELLKMTSPCEKL----IRRDIARTYPEHNFFKEKDSLGQEVLFN 229
Query: 579 VLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVALCERM-LPDYYNTRVVGALV 637
V+ AY+ + +GYCQ + +LL+ EEEAF + V L + L + + + +
Sbjct: 230 VMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGL 289
Query: 638 DQGIFEELTRDFLPQLSEKMQDLGVISSI-SLSWFLTLFLSVMPFESAVVIVDCFFYEGI 696
FE + ++ LP+L Q +S+ + SWFLT+FL+ P A I D F EG+
Sbjct: 290 CMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGL 349
Query: 697 KVILQVALAVLDANMEQLLGCSDEG 721
+++ +V LA+L N +L+ EG
Sbjct: 350 EIVFRVGLALLQMNQAELMQLDMEG 374
>gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 105 bits (263), Expect = 2e-22
Identities = 75/255 (29%), Positives = 128/255 (50%), Gaps = 21/255 (8%)
Query: 496 YRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVT---HPGYYAELVEKSTGKYSLATEE 552
Y K A + GIP+ R ++WL + + + E+S +
Sbjct: 74 YDALKAVARLSTGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQ 133
Query: 553 IERDLHRS-MPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLL--LYGSE 609
I +DLHR+ + + E L+RVL AYA N T+GYCQ NI+ +++L + G+E
Sbjct: 134 IVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNE 193
Query: 610 EEAFWLLVALCERMLPDYYNTRVVGAL-VDQGIFEELTRDFLPQLSEKMQDLG------- 661
+A +++ L +++LP+ Y + AL VD +F +L R LP+LS+ + L
Sbjct: 194 GDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKES 253
Query: 662 -------VISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQL 714
+ + ++ WFLTLF + +P ++ + I D F+EG ++IL+V+LA+ EQ+
Sbjct: 254 GGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQI 313
Query: 715 LGCSDEGEAMTMLGR 729
C E + +GR
Sbjct: 314 ECCETADEFYSTMGR 328
>gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 105 bits (263), Expect = 2e-22
Identities = 75/255 (29%), Positives = 128/255 (50%), Gaps = 21/255 (8%)
Query: 496 YRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVT---HPGYYAELVEKSTGKYSLATEE 552
Y K A + GIP+ R ++WL + + + E+S +
Sbjct: 74 YDALKAVARLSTGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQ 133
Query: 553 IERDLHRS-MPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLL--LYGSE 609
I +DLHR+ + + E L+RVL AYA N T+GYCQ NI+ +++L + G+E
Sbjct: 134 IVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNE 193
Query: 610 EEAFWLLVALCERMLPDYYNTRVVGAL-VDQGIFEELTRDFLPQLSEKMQDLG------- 661
+A +++ L +++LP+ Y + AL VD +F +L R LP+LS+ + L
Sbjct: 194 GDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKES 253
Query: 662 -------VISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQL 714
+ + ++ WFLTLF + +P ++ + I D F+EG ++IL+V+LA+ EQ+
Sbjct: 254 GGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQI 313
Query: 715 LGCSDEGEAMTMLGR 729
C E + +GR
Sbjct: 314 ECCETADEFYSTMGR 328
>gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 105 bits (263), Expect = 2e-22
Identities = 75/255 (29%), Positives = 128/255 (50%), Gaps = 21/255 (8%)
Query: 496 YRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVT---HPGYYAELVEKSTGKYSLATEE 552
Y K A + GIP+ R ++WL + + + E+S +
Sbjct: 74 YDALKAVARLSTGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQ 133
Query: 553 IERDLHRS-MPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLL--LYGSE 609
I +DLHR+ + + E L+RVL AYA N T+GYCQ NI+ +++L + G+E
Sbjct: 134 IVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNE 193
Query: 610 EEAFWLLVALCERMLPDYYNTRVVGAL-VDQGIFEELTRDFLPQLSEKMQDLG------- 661
+A +++ L +++LP+ Y + AL VD +F +L R LP+LS+ + L
Sbjct: 194 GDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKES 253
Query: 662 -------VISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQL 714
+ + ++ WFLTLF + +P ++ + I D F+EG ++IL+V+LA+ EQ+
Sbjct: 254 GGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQI 313
Query: 715 LGCSDEGEAMTMLGR 729
C E + +GR
Sbjct: 314 ECCETADEFYSTMGR 328
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 105 bits (263), Expect = 2e-22
Identities = 94/338 (27%), Positives = 149/338 (44%), Gaps = 34/338 (10%)
Query: 391 SDFLQKTPSKQPGSIGSRKASVVDPSTESSPAPQEGSEQPASPASPLSSRQSFCAQEAPT 450
+D L + + S R+ + PS PQ GS+ P+ P + + +
Sbjct: 468 TDTLYEVVCLESESERERRKTTASPSVR---LPQSGSQSSVIPSPPEDDEEEDNDEPLLS 524
Query: 451 ASQGLLKLFQKNSPMEDLGAKGAKEKMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIP 510
S + K + +E G +K WH++ R + +LV G+P
Sbjct: 525 GSGDVSKECAEKI-LETWGELLSK-------WHLNL--------NVRPKQLSSLVRNGVP 568
Query: 511 ESLRGELWLLFSGAWNEMVTHPGYYAELVEKST---GKYSLATEEIERDLHRSMPEHPAF 567
E+LRGE+W L +G N LVEK K S I RD++R+ P H F
Sbjct: 569 EALRGEVWQLLAGCHNN--------DHLVEKYRILITKESPQDSAITRDINRTFPAHDYF 620
Query: 568 QNELGIA--ALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVALC-ERML 624
++ G +L ++ AY+ + IGYCQ + + +VLLL+ EE+AF +LV + + L
Sbjct: 621 KDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGL 680
Query: 625 PDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSISLS-WFLTLFLSVMPFES 683
+ + E L ++++P L D+ + + + S WFLTLF + P
Sbjct: 681 RELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYM 740
Query: 684 AVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEG 721
I+D EGI VI VAL +L + + LL EG
Sbjct: 741 VFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEG 778
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 102 bits (253), Expect = 3e-21
Identities = 67/229 (29%), Positives = 116/229 (50%), Gaps = 7/229 (3%)
Query: 498 TAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDL 557
T K + KGIP LRGE+W L Y++L ++ G S +I+ D+
Sbjct: 90 TEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARG-CSPDIRQIDLDV 148
Query: 558 HRSMPEHPAFQNELGIA--ALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWL 615
+R+ +H F++ G+ +L VL AY+ N +GYCQ M+ +T++LL+Y +EE+AFW
Sbjct: 149 NRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWA 208
Query: 616 LVALC---ERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSI-SLSWF 671
LV L + + ++ L Q E++ FL +L + + + +S ++ WF
Sbjct: 209 LVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWF 268
Query: 672 LTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDE 720
FL PF + I D + +EG +V+ ++ +L + + L+ S E
Sbjct: 269 FQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKLSME 317
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 102 bits (253), Expect = 3e-21
Identities = 67/229 (29%), Positives = 116/229 (50%), Gaps = 7/229 (3%)
Query: 498 TAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDL 557
T K + KGIP LRGE+W L Y++L ++ G S +I+ D+
Sbjct: 107 TEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARG-CSPDIRQIDLDV 165
Query: 558 HRSMPEHPAFQNELGIA--ALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWL 615
+R+ +H F++ G+ +L VL AY+ N +GYCQ M+ +T++LL+Y +EE+AFW
Sbjct: 166 NRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWA 225
Query: 616 LVALC---ERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSI-SLSWF 671
LV L + + ++ L Q E++ FL +L + + + +S ++ WF
Sbjct: 226 LVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWF 285
Query: 672 LTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDE 720
FL PF + I D + +EG +V+ ++ +L + + L+ S E
Sbjct: 286 FQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKLSME 334
>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
[Homo sapiens]
Length = 1168
Score = 97.1 bits (240), Expect = 1e-19
Identities = 88/342 (25%), Positives = 143/342 (41%), Gaps = 44/342 (12%)
Query: 414 DPSTESSPAPQEGSEQPASPASPLSSRQSFCA--QEAPTASQGLLKLFQKNSPMEDLGAK 471
D S+ + G P SP P+ F +E S+ L +L+QK + L +
Sbjct: 677 DSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLR 736
Query: 472 GAKEKMKEES---------------------------WHIHFFEYGRGVCMYRTAKTRAL 504
KE K ++ W GR + K +
Sbjct: 737 MEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSA 796
Query: 505 VLKGIPESLRGELWLLFSGAWNEMVTHPGY-------YAELVEKSTGKYSLATEEIERDL 557
V +G+P RGE+W + ++ P Y EL+++ T + I DL
Sbjct: 797 VGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQ----HAILIDL 852
Query: 558 HRSMPEHPAFQNELGIA--ALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWL 615
R+ P HP F +LG +L +L AY+ + +GYCQ ++ V +LLL+ SEEEAF +
Sbjct: 853 GRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKM 912
Query: 616 LVALCERM-LPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSI-SLSWFLT 673
L L M L Y ++ + L D+ L +++ + S+ + WFLT
Sbjct: 913 LKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLT 972
Query: 674 LFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLL 715
+F S P + D F +G +VI +VAL++L ++ +L
Sbjct: 973 MFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLIL 1014
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 90.5 bits (223), Expect = 9e-18
Identities = 69/249 (27%), Positives = 117/249 (46%), Gaps = 19/249 (7%)
Query: 504 LVLKGIPESLRGELWLLFSGAW-------NEMVTHPGYYAELVEKSTGKYSLATEEIERD 556
L+ +G+P+S RGE+W + + N+ Y EL+++ T + I D
Sbjct: 914 LLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQ----HAILVD 969
Query: 557 LHRSMPEHPAFQNELGIAALR--RVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFW 614
L R+ P HP F +LG L +L AY+ + +GYCQ ++ V VLLL+ SEE+AF
Sbjct: 970 LGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFE 1029
Query: 615 LLVALCERM-LPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSI-SLSWFL 672
+L L + Y ++ + L D+ L +++ + S+ + WFL
Sbjct: 1030 MLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFL 1089
Query: 673 TLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLD 732
TLF S + D F +G +VI +VAL++L + ++ C E+ + +L
Sbjct: 1090 TLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMEC----ESFENIVEFLK 1145
Query: 733 NVVNKQSVS 741
N + + S
Sbjct: 1146 NTLPDMNTS 1154
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 77.0 bits (188), Expect = 1e-13
Identities = 67/254 (26%), Positives = 115/254 (45%), Gaps = 15/254 (5%)
Query: 505 VLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSMPEH 564
V KGIP ++RG +W + + +PG Y + E+ + S I+ D+ ++ H
Sbjct: 97 VYKGIPMNIRGPVWSVLLNIQEIKLKNPGRYQIMKERGK-RSSEHIHHIDLDVRTTLRNH 155
Query: 565 PAFQNELGIAA--LRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVALC-- 620
F++ G L +L AY+ NP +GYC+ ++ +T++ LLY EE+AFW LV L
Sbjct: 156 VFFRDRYGAKQRELFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEEDAFWALVQLLAS 215
Query: 621 -ERMLPDYY--NTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISS-ISLSWFLTLFL 676
LP ++ N V L DQ E + P+ G+ SL L +
Sbjct: 216 ERHSLPGFHSPNGGTVQGLQDQQ--EHVVPKSQPKTMWHQDKEGLCGQCASLGCLLRNLI 273
Query: 677 SVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDN-VV 735
+ + + D + EG +V++ + L ++L+ S G + ++ D +
Sbjct: 274 DGISLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRLMKTSRCGLWARLRNQFFDTWAM 333
Query: 736 NKQSVSPPIPHLRA 749
N +V + HLRA
Sbjct: 334 NDDTV---LKHLRA 344
>gi|14149985 TBC1 domain family, member 3F [Homo sapiens]
Length = 549
Score = 72.8 bits (177), Expect = 2e-12
Identities = 61/251 (24%), Positives = 108/251 (43%), Gaps = 13/251 (5%)
Query: 507 KGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPA 566
KG+P ++RG +W + + +PG Y + EK K S + I+RD+ ++ +H
Sbjct: 100 KGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGK-KSSEHIQRIDRDVSGTLRKHIF 158
Query: 567 FQNELGIAA--LRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVALC---E 621
F++ G L +L AY NP +GYC+ ++ + ++ LLY EE+AFW LV L
Sbjct: 159 FRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASER 218
Query: 622 RMLPDYY--NTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSIS-LSWFLTLFLSV 678
L ++ N V L DQ E + P+ + S L + + +
Sbjct: 219 HSLQGFHSPNGGTVQGLQDQQ--EHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDG 276
Query: 679 MPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVVNKQ 738
+ + + D + EG + ++ + ++L S G R++D +
Sbjct: 277 ISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDE 336
Query: 739 SVSPPIPHLRA 749
+ HLRA
Sbjct: 337 DT--VLKHLRA 345
>gi|149999613 TBC1 domain family, member 3B [Homo sapiens]
Length = 549
Score = 72.4 bits (176), Expect = 3e-12
Identities = 62/251 (24%), Positives = 109/251 (43%), Gaps = 13/251 (5%)
Query: 507 KGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPA 566
KG+P ++RG +W + + +PG Y + EK + S + I+RD+ ++ +H
Sbjct: 100 KGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGK-RSSEHIQRIDRDISGTLRKHMF 158
Query: 567 FQNELGIAA--LRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVALC---E 621
F++ G L +L AY NP +GYC+ ++ + ++ LLY EE+AFW LV L
Sbjct: 159 FRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASER 218
Query: 622 RMLPDYY--NTRVVGALVDQGIFEELTRDFLPQLSEKMQDL-GVISSISLSWFLTLFLSV 678
L ++ N V L DQ T + +DL G S L + + +
Sbjct: 219 HSLQGFHSPNGGTVQGLQDQQEHVVATSQSKTMGHQDKKDLCGQCS--PLGCLIRILIDG 276
Query: 679 MPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVVNKQ 738
+ + + D + EG + ++ + ++L S G R++D +
Sbjct: 277 ISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDE 336
Query: 739 SVSPPIPHLRA 749
+ HLRA
Sbjct: 337 DT--VLKHLRA 345
>gi|226693407 TBC1 domain family, member 3H [Homo sapiens]
Length = 549
Score = 72.0 bits (175), Expect = 3e-12
Identities = 60/251 (23%), Positives = 108/251 (43%), Gaps = 13/251 (5%)
Query: 507 KGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPA 566
KG+P ++RG +W + + +PG Y + EK + S + I+RD+ ++ +H
Sbjct: 100 KGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGK-RSSEHIQRIDRDISGTLRKHMF 158
Query: 567 FQNELGIAA--LRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVALC---E 621
F++ G L +L AY NP +GYC+ ++ + ++ LLY EE+AFW LV L
Sbjct: 159 FRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASER 218
Query: 622 RMLPDYY--NTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSIS-LSWFLTLFLSV 678
L ++ N V L DQ E + P+ + S L + + +
Sbjct: 219 HSLQGFHSPNGGTVQGLQDQQ--EHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDG 276
Query: 679 MPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVVNKQ 738
+ + + D + EG + ++ + ++L S G R++D +
Sbjct: 277 ISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDE 336
Query: 739 SVSPPIPHLRA 749
+ HLRA
Sbjct: 337 DT--VLKHLRA 345
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,010,566
Number of Sequences: 37866
Number of extensions: 2352808
Number of successful extensions: 11043
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 92
Number of HSP's successfully gapped in prelim test: 104
Number of HSP's that attempted gapping in prelim test: 10655
Number of HSP's gapped (non-prelim): 373
length of query: 1250
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1136
effective length of database: 13,930,794
effective search space: 15825381984
effective search space used: 15825381984
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.