Guide to the Human Genome
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Search of human proteins with 132566532

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|132566532 dual oxidase 2 precursor [Homo sapiens]
         (1548 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|132566532 dual oxidase 2 precursor [Homo sapiens]                 3157   0.0  
gi|20149640 dual oxidase 1 precursor [Homo sapiens]                  2435   0.0  
gi|28872751 dual oxidase 1 precursor [Homo sapiens]                  2435   0.0  
gi|20127624 NADPH oxidase, EF-hand calcium binding domain 5 [Hom...   248   3e-65
gi|11136626 NADPH oxidase 3 [Homo sapiens]                            235   2e-61
gi|6996021 cytochrome b-245 beta polypeptide [Homo sapiens]           227   8e-59
gi|148536873 NADPH oxidase 1 isoform long [Homo sapiens]              224   5e-58
gi|7669510 NADPH oxidase 1 isoform long variant [Homo sapiens]        191   5e-48
gi|126517478 peroxidasin homolog-like [Homo sapiens]                  148   3e-35
gi|109150416 peroxidasin [Homo sapiens]                               145   4e-34
gi|219842348 NADPH oxidase 4 isoform c [Homo sapiens]                 144   5e-34
gi|8393843 NADPH oxidase 4 isoform a [Homo sapiens]                   144   5e-34
gi|4503595 eosinophil peroxidase [Homo sapiens]                       124   7e-28
gi|28558982 thyroid peroxidase isoform a [Homo sapiens]               120   1e-26
gi|28558988 thyroid peroxidase isoform d [Homo sapiens]               120   1e-26
gi|231569458 lactoperoxidase isoform 3 preproprotein [Homo sapiens]   119   2e-26
gi|40549418 lactoperoxidase isoform 1 preproprotein [Homo sapiens]    117   7e-26
gi|4557759 myeloperoxidase [Homo sapiens]                             115   4e-25
gi|219842346 NADPH oxidase 4 isoform b [Homo sapiens]                  87   1e-16
gi|28558984 thyroid peroxidase isoform b [Homo sapiens]                79   3e-14
gi|40254415 guanylate cyclase activator 1A (retina) [Homo sapiens]     66   3e-10
gi|28558990 thyroid peroxidase isoform e [Homo sapiens]                65   4e-10
gi|4506025 protein phosphatase 3, regulatory subunit B, alpha is...    62   3e-09
gi|13375787 EF-hand calcium binding domain 1 isoform a [Homo sap...    60   1e-08
gi|98985795 neurocalcin delta [Homo sapiens]                           60   2e-08
gi|98985793 neurocalcin delta [Homo sapiens]                           60   2e-08
gi|98985791 neurocalcin delta [Homo sapiens]                           60   2e-08
gi|98985789 neurocalcin delta [Homo sapiens]                           60   2e-08
gi|98985787 neurocalcin delta [Homo sapiens]                           60   2e-08
gi|98985785 neurocalcin delta [Homo sapiens]                           60   2e-08

>gi|132566532 dual oxidase 2 precursor [Homo sapiens]
          Length = 1548

 Score = 3157 bits (8185), Expect = 0.0
 Identities = 1548/1548 (100%), Positives = 1548/1548 (100%)

Query: 1    MLRARPEALMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRR 60
            MLRARPEALMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRR
Sbjct: 1    MLRARPEALMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRR 60

Query: 61   VPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVE 120
            VPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVE
Sbjct: 61   VPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVE 120

Query: 121  TPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLD 180
            TPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLD
Sbjct: 121  TPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLD 180

Query: 181  GSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAF 240
            GSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAF
Sbjct: 181  GSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAF 240

Query: 241  GAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYE 300
            GAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYE
Sbjct: 241  GAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYE 300

Query: 301  WLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKG 360
            WLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKG
Sbjct: 301  WLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKG 360

Query: 361  FQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKF 420
            FQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKF
Sbjct: 361  FQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKF 420

Query: 421  SRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLS 480
            SRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLS
Sbjct: 421  SRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLS 480

Query: 481  QLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTL 540
            QLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTL
Sbjct: 481  QLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTL 540

Query: 541  RDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAI 600
            RDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAI
Sbjct: 541  RDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAI 600

Query: 601  TIIALCCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSS 660
            TIIALCCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSS
Sbjct: 601  TIIALCCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSS 660

Query: 661  PIIIQLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLF 720
            PIIIQLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLF
Sbjct: 661  PIIIQLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLF 720

Query: 721  SSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVL 780
            SSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVL
Sbjct: 721  SSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVL 780

Query: 781  DINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLS 840
            DINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLS
Sbjct: 781  DINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLS 840

Query: 841  FREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQL 900
            FREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQL
Sbjct: 841  FREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQL 900

Query: 901  AEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNI 960
            AEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNI
Sbjct: 901  AEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNI 960

Query: 961  SCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQ 1020
            SCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQ
Sbjct: 961  SCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQ 1020

Query: 1021 RGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGI 1080
            RGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGI
Sbjct: 1021 RGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGI 1080

Query: 1081 ILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAIL 1140
            ILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAIL
Sbjct: 1081 ILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAIL 1140

Query: 1141 HSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLA 1200
            HSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLA
Sbjct: 1141 HSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLA 1200

Query: 1201 IMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGD 1260
            IMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGD
Sbjct: 1201 IMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGD 1260

Query: 1261 KLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTL 1320
            KLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTL
Sbjct: 1261 KLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTL 1320

Query: 1321 TSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVS 1380
            TSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVS
Sbjct: 1321 TSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVS 1380

Query: 1381 VLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEEND 1440
            VLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEEND
Sbjct: 1381 VLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEEND 1440

Query: 1441 HQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFN 1500
            HQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFN
Sbjct: 1441 HQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFN 1500

Query: 1501 SLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF 1548
            SLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF
Sbjct: 1501 SLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF 1548


>gi|20149640 dual oxidase 1 precursor [Homo sapiens]
          Length = 1551

 Score = 2435 bits (6310), Expect = 0.0
 Identities = 1207/1551 (77%), Positives = 1331/1551 (85%), Gaps = 15/1551 (0%)

Query: 9    LMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYADG 68
            L L   LL G+  P G Q+ +S  WEVQR+DGW+NNL  H  G+ G RLQR VPA+YADG
Sbjct: 5    LALAWTLLVGAWTPLGAQNPIS--WEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADG 62

Query: 69   VYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVETPGCPAEF 128
            VYQ L EP LPNPR LSN  +RG AGL SL NRTVLGVFFGYHVLSD+VSVETPGCPAEF
Sbjct: 63   VYQPLGEPHLPNPRDLSNTISRGPAGLASLRNRTVLGVFFGYHVLSDLVSVETPGCPAEF 122

Query: 129  LNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSS 188
            LNIRIPPGDP+FDPDQRGDVVLPFQRSRWDPETGRSPSNPRD ANQVTGWLDGSAIYGSS
Sbjct: 123  LNIRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDPANQVTGWLDGSAIYGSS 182

Query: 189  HSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNRE 248
            HSWSDALRSFS GQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNRE
Sbjct: 183  HSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNRE 242

Query: 249  PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQK 308
            PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQK
Sbjct: 243  PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQK 302

Query: 309  TLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSSQALR 368
            TLPEYTGYRPFLDPSIS EFV ASEQF STMVPPGVYMRNASCHF+ V+N+    S+ALR
Sbjct: 303  TLPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSVSRALR 362

Query: 369  VCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKFSRTDYVAS 428
            VCN+YW RE+P+L S ++V+ LLLGMASQI+E ED+++VED+RD+WPGP KFSRTD++AS
Sbjct: 363  VCNSYWSREHPSLQSAEDVDALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSRTDHLAS 422

Query: 429  SIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNV---DPQVLEATAALYNQDLSQLELL 485
             +QRGRD+GLPSY++A  A GL     W D+NP +   +  VLEATAALYNQDLS LELL
Sbjct: 423  CLQRGRDLGLPSYTKARAALGLSPITRWQDINPALSRSNDTVLEATAALYNQDLSWLELL 482

Query: 486  LGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTLRDVLV 545
             GGLLESH DPGPLFS IVL+QFVRLRDGDRYWFENTRNGLFSKKEIE+IRNTTL+DVLV
Sbjct: 483  PGGLLESHRDPGPLFSTIVLEQFVRLRDGDRYWFENTRNGLFSKKEIEEIRNTTLQDVLV 542

Query: 546  AVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAITIIAL 605
            AVINIDPSALQPNVFVWHKG PCPQP+QL+T+GLP CAP  V D+FEGS  GF +TI  L
Sbjct: 543  AVINIDPSALQPNVFVWHKGDPCPQPRQLSTEGLPACAPSVVRDYFEGSGFGFGVTIGTL 602

Query: 606  CCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSSPIIIQ 665
            CC PLVSLL + +VA  R R  K+LQ + ++S+  E    G+ A+EW G KE   P+++ 
Sbjct: 603  CCFPLVSLLSAWIVARLRMRNFKRLQGQDRQSIVSEKLVGGMEALEWQGHKEPCRPVLVY 662

Query: 666  LLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLFSSEEE 725
            L   + ++V++  LTVLR +QLQP Q+VN +LS+NRG RTLLLKIPKEYDLVLLF+ EEE
Sbjct: 663  LQPGQ-IRVVDGRLTVLRTIQLQPPQKVNFVLSSNRGRRTLLLKIPKEYDLVLLFNLEEE 721

Query: 726  RGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVLDINQA 785
            R A V+ L        L +   E+ E+EL R AVT++QR  +LE FFRHLF+QVLDINQA
Sbjct: 722  RQALVENLRGALKESGLSIQEWELREQELMRAAVTREQRRHLLETFFRHLFSQVLDINQA 781

Query: 786  DAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFL 845
            DAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFL
Sbjct: 782  DAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFL 841

Query: 846  DILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVE 905
            DILVVFMKGSPE+KSRLMF MYD D NG +SKDEF  M+RSFIEISNNCLSKAQLAEVVE
Sbjct: 842  DILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVE 901

Query: 906  SMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFK------QN 959
            SMFRESGFQDKEELTWEDFHFMLRDH+SELRFTQLCVKG       I+D+ +      Q+
Sbjct: 902  SMFRESGFQDKEELTWEDFHFMLRDHNSELRFTQLCVKGVEVP-EVIKDLCRRASYISQD 960

Query: 960  ISCRVSFITRTPGERSHPQGLGPPAPEAPELGGPG--LKKRFGKKAAVPTPRLYTEALQE 1017
            + C    ++           L P   + P    P   +++RFGKK     P L+TEA +E
Sbjct: 961  MICPSPRVSARCSRSDIETELTPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHRE 1020

Query: 1018 KMQRGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTL 1077
            K QR  L Q +QQ+KRF+ENYRRHI CVA+F AI  G+F +RAYYY FA+  + I  TT 
Sbjct: 1021 KFQRSCLHQTVQQFKRFIENYRRHIGCVAVFYAIAGGLFLERAYYYAFAAHHTGITDTTR 1080

Query: 1078 VGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVL 1137
            VGIILSRGTAAS+SFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHR IA  A+VL
Sbjct: 1081 VGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRLIASTAIVL 1140

Query: 1138 AILHSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLL 1197
             +LHS GH VNVY+FS+SPLS+L+C+FP +F +DGS+LPQK+YWWFFQTVPG+TGV+LLL
Sbjct: 1141 TVLHSVGHVVNVYLFSISPLSVLSCLFPGLFHDDGSELPQKYYWWFFQTVPGLTGVVLLL 1200

Query: 1198 VLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIY 1257
            +LAIMYVFASHHFRRRSFRGFWLTHHLYILLY LLIIHGS+ALIQLP FHI+FLVPAIIY
Sbjct: 1201 ILAIMYVFASHHFRRRSFRGFWLTHHLYILLYVLLIIHGSFALIQLPRFHIFFLVPAIIY 1260

Query: 1258 GGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHP 1317
            GGDKLVSLSRKKVEISVVKAELLPSGVT+L+FQRPQGFEYKSGQWVRIACLALGTTEYHP
Sbjct: 1261 GGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHP 1320

Query: 1318 FTLTSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKF 1377
            FTLTSAPHEDTLSLHIRA GPWTTRLREIYS+P G+ CA YPKLYLDGPFGEGHQEWHKF
Sbjct: 1321 FTLTSAPHEDTLSLHIRAAGPWTTRLREIYSAPTGDRCARYPKLYLDGPFGEGHQEWHKF 1380

Query: 1378 EVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVE 1437
            EVSVLVGGGIGVTPFASILKDLVFKSS+  Q+ CKKIYFIWVTRTQRQFEWLADII+EVE
Sbjct: 1381 EVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVE 1440

Query: 1438 ENDHQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEP 1497
            ENDHQDLVSVHIY+TQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEP
Sbjct: 1441 ENDHQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEP 1500

Query: 1498 FFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF 1548
            FFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQL+NRQDR HF HHYENF
Sbjct: 1501 FFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF 1551


>gi|28872751 dual oxidase 1 precursor [Homo sapiens]
          Length = 1551

 Score = 2435 bits (6310), Expect = 0.0
 Identities = 1207/1551 (77%), Positives = 1331/1551 (85%), Gaps = 15/1551 (0%)

Query: 9    LMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYADG 68
            L L   LL G+  P G Q+ +S  WEVQR+DGW+NNL  H  G+ G RLQR VPA+YADG
Sbjct: 5    LALAWTLLVGAWTPLGAQNPIS--WEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADG 62

Query: 69   VYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVETPGCPAEF 128
            VYQ L EP LPNPR LSN  +RG AGL SL NRTVLGVFFGYHVLSD+VSVETPGCPAEF
Sbjct: 63   VYQPLGEPHLPNPRDLSNTISRGPAGLASLRNRTVLGVFFGYHVLSDLVSVETPGCPAEF 122

Query: 129  LNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSS 188
            LNIRIPPGDP+FDPDQRGDVVLPFQRSRWDPETGRSPSNPRD ANQVTGWLDGSAIYGSS
Sbjct: 123  LNIRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDPANQVTGWLDGSAIYGSS 182

Query: 189  HSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNRE 248
            HSWSDALRSFS GQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNRE
Sbjct: 183  HSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNRE 242

Query: 249  PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQK 308
            PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQK
Sbjct: 243  PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQK 302

Query: 309  TLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSSQALR 368
            TLPEYTGYRPFLDPSIS EFV ASEQF STMVPPGVYMRNASCHF+ V+N+    S+ALR
Sbjct: 303  TLPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSVSRALR 362

Query: 369  VCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKFSRTDYVAS 428
            VCN+YW RE+P+L S ++V+ LLLGMASQI+E ED+++VED+RD+WPGP KFSRTD++AS
Sbjct: 363  VCNSYWSREHPSLQSAEDVDALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSRTDHLAS 422

Query: 429  SIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNV---DPQVLEATAALYNQDLSQLELL 485
             +QRGRD+GLPSY++A  A GL     W D+NP +   +  VLEATAALYNQDLS LELL
Sbjct: 423  CLQRGRDLGLPSYTKARAALGLSPITRWQDINPALSRSNDTVLEATAALYNQDLSWLELL 482

Query: 486  LGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTLRDVLV 545
             GGLLESH DPGPLFS IVL+QFVRLRDGDRYWFENTRNGLFSKKEIE+IRNTTL+DVLV
Sbjct: 483  PGGLLESHRDPGPLFSTIVLEQFVRLRDGDRYWFENTRNGLFSKKEIEEIRNTTLQDVLV 542

Query: 546  AVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAITIIAL 605
            AVINIDPSALQPNVFVWHKG PCPQP+QL+T+GLP CAP  V D+FEGS  GF +TI  L
Sbjct: 543  AVINIDPSALQPNVFVWHKGDPCPQPRQLSTEGLPACAPSVVRDYFEGSGFGFGVTIGTL 602

Query: 606  CCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSSPIIIQ 665
            CC PLVSLL + +VA  R R  K+LQ + ++S+  E    G+ A+EW G KE   P+++ 
Sbjct: 603  CCFPLVSLLSAWIVARLRMRNFKRLQGQDRQSIVSEKLVGGMEALEWQGHKEPCRPVLVY 662

Query: 666  LLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLFSSEEE 725
            L   + ++V++  LTVLR +QLQP Q+VN +LS+NRG RTLLLKIPKEYDLVLLF+ EEE
Sbjct: 663  LQPGQ-IRVVDGRLTVLRTIQLQPPQKVNFVLSSNRGRRTLLLKIPKEYDLVLLFNLEEE 721

Query: 726  RGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVLDINQA 785
            R A V+ L        L +   E+ E+EL R AVT++QR  +LE FFRHLF+QVLDINQA
Sbjct: 722  RQALVENLRGALKESGLSIQEWELREQELMRAAVTREQRRHLLETFFRHLFSQVLDINQA 781

Query: 786  DAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFL 845
            DAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFL
Sbjct: 782  DAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFL 841

Query: 846  DILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVE 905
            DILVVFMKGSPE+KSRLMF MYD D NG +SKDEF  M+RSFIEISNNCLSKAQLAEVVE
Sbjct: 842  DILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVE 901

Query: 906  SMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFK------QN 959
            SMFRESGFQDKEELTWEDFHFMLRDH+SELRFTQLCVKG       I+D+ +      Q+
Sbjct: 902  SMFRESGFQDKEELTWEDFHFMLRDHNSELRFTQLCVKGVEVP-EVIKDLCRRASYISQD 960

Query: 960  ISCRVSFITRTPGERSHPQGLGPPAPEAPELGGPG--LKKRFGKKAAVPTPRLYTEALQE 1017
            + C    ++           L P   + P    P   +++RFGKK     P L+TEA +E
Sbjct: 961  MICPSPRVSARCSRSDIETELTPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHRE 1020

Query: 1018 KMQRGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTL 1077
            K QR  L Q +QQ+KRF+ENYRRHI CVA+F AI  G+F +RAYYY FA+  + I  TT 
Sbjct: 1021 KFQRSCLHQTVQQFKRFIENYRRHIGCVAVFYAIAGGLFLERAYYYAFAAHHTGITDTTR 1080

Query: 1078 VGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVL 1137
            VGIILSRGTAAS+SFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHR IA  A+VL
Sbjct: 1081 VGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRLIASTAIVL 1140

Query: 1138 AILHSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLL 1197
             +LHS GH VNVY+FS+SPLS+L+C+FP +F +DGS+LPQK+YWWFFQTVPG+TGV+LLL
Sbjct: 1141 TVLHSVGHVVNVYLFSISPLSVLSCLFPGLFHDDGSELPQKYYWWFFQTVPGLTGVVLLL 1200

Query: 1198 VLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIY 1257
            +LAIMYVFASHHFRRRSFRGFWLTHHLYILLY LLIIHGS+ALIQLP FHI+FLVPAIIY
Sbjct: 1201 ILAIMYVFASHHFRRRSFRGFWLTHHLYILLYVLLIIHGSFALIQLPRFHIFFLVPAIIY 1260

Query: 1258 GGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHP 1317
            GGDKLVSLSRKKVEISVVKAELLPSGVT+L+FQRPQGFEYKSGQWVRIACLALGTTEYHP
Sbjct: 1261 GGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHP 1320

Query: 1318 FTLTSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKF 1377
            FTLTSAPHEDTLSLHIRA GPWTTRLREIYS+P G+ CA YPKLYLDGPFGEGHQEWHKF
Sbjct: 1321 FTLTSAPHEDTLSLHIRAAGPWTTRLREIYSAPTGDRCARYPKLYLDGPFGEGHQEWHKF 1380

Query: 1378 EVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVE 1437
            EVSVLVGGGIGVTPFASILKDLVFKSS+  Q+ CKKIYFIWVTRTQRQFEWLADII+EVE
Sbjct: 1381 EVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVE 1440

Query: 1438 ENDHQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEP 1497
            ENDHQDLVSVHIY+TQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEP
Sbjct: 1441 ENDHQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEP 1500

Query: 1498 FFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF 1548
            FFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQL+NRQDR HF HHYENF
Sbjct: 1501 FFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF 1551


>gi|20127624 NADPH oxidase, EF-hand calcium binding domain 5 [Homo
            sapiens]
          Length = 747

 Score =  248 bits (633), Expect = 3e-65
 Identities = 213/807 (26%), Positives = 352/807 (43%), Gaps = 176/807 (21%)

Query: 805  ELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEDKSRLMF 864
            E+S  EF  +L +K +  F E  F+L D D +G ++ +E  + L + + GSP DK + +F
Sbjct: 26   EISLQEFKAALHVK-ESFFAERFFALFDSDRSGTITLQELQEALTLLIHGSPMDKLKFLF 84

Query: 865  TMYDLD---ENGFLSKDEFFT-----MMRSFIEISNNCLSKAQLAEVVESMFRESGF--- 913
             +YD+D     G  +  E+          S +   +  +   +L  V++S  RES     
Sbjct: 85   QVYDIDVCARQGASAGTEWGAGAGPHWASSPLGTGSGSIDPDELRTVLQSCLRESAISLP 144

Query: 914  -QDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNISCRVSFITRTPG 972
             +  ++LT   F     D +  + F +L            RD  +           R PG
Sbjct: 145  DEKLDQLTLALFESADADGNGAITFEEL------------RDELQ-----------RFPG 181

Query: 973  ER-----SHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQRGFLAQK 1027
                   S    L  PAP                    P PR                + 
Sbjct: 182  VMENLTISAAHWLTAPAPR-------------------PRPR----------------RP 206

Query: 1028 LQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTA 1087
             Q  + +  N+R  + C+A ++ + V +F   A      S   D+  + +V    ++G  
Sbjct: 207  RQLTRAYWHNHRSQLFCLATYAGLHVLLFGLAA------SAHRDLGASVMV----AKGCG 256

Query: 1088 ASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAILHSAGHAV 1147
              ++F  S+I + M R  +T+LR T+L + +P D  + FH+ +    V L+++H+  H V
Sbjct: 257  QCLNFDCSFIAVLMLRRCLTWLRATWLAQVLPLDQNIQFHQLMGYVVVGLSLVHTVAHTV 316

Query: 1148 NVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGM---------TGVLLLLV 1198
            N  + + +  S                 P +F+     T PG+         TGV LLL+
Sbjct: 317  NFVLQAQAEAS-----------------PFQFWELLLTTRPGIGWVHGSASPTGVALLLL 359

Query: 1199 LAIMYVFASHHFRRRS-FRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIY 1257
            L +M++ +S   RR   F  F+ TH  Y+L++ LLI HG       P F  + LVP I++
Sbjct: 360  LLLMFICSSSCIRRSGHFEVFYWTHLSYLLVWLLLIFHG-------PNFWKWLLVPGILF 412

Query: 1258 GGDKLVSLS-RKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYH 1316
              +K + L+  +   + +++  LLPS VT+L  +RP  F Y+ G ++ +    +   E+H
Sbjct: 413  FLEKAIGLAVSRMAAVCIMEVNLLPSKVTHLLIKRPPFFHYRPGDYLYLNIPTIARYEWH 472

Query: 1317 PFTLTSAPHE-DTLSLHIRAVGPWTTRLREIY--SSPKGNGCAGYP-------------- 1359
            PFT++SAP + DT+ LHIR+ G WT RL E +  S P G G                   
Sbjct: 473  PFTISSAPEQKDTIWLHIRSQGQWTNRLYESFKASDPLGRGSKRLSRSVTMRKSQRSSKG 532

Query: 1360 -------------KLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFK---- 1402
                         K Y+DGP+G   +     E +VL+G GIG+TPFASIL+ ++++    
Sbjct: 533  SEILLEKHKFCNIKCYIDGPYGTPTRRIFASEHAVLIGAGIGITPFASILQSIMYRHQKR 592

Query: 1403 ------------SSLGSQMLCKKIYFIWVTRTQRQFEWLADII-----QEVEENDHQDLV 1445
                          +   M   K+ FIW+ R QR FEW   ++      + EE  +   +
Sbjct: 593  KHTCPSCQHSWIEGVQDNMKLHKVDFIWINRDQRSFEWFVSLLTKLEMDQAEEAQYGRFL 652

Query: 1446 SVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEV 1505
             +H+Y+T    K D++   L +          +   TGL++ T  GRP +   F   Q+V
Sbjct: 653  ELHMYMTSALGKNDMKAIGLQMALDLLANKEKKDSITGLQTRTQPGRPDWSKVF---QKV 709

Query: 1506 HPQVR-KIGVFSCGPPGMTKNVEKACQ 1531
              + + K+ VF CG P + K ++  C+
Sbjct: 710  AAEKKGKVQVFFCGSPALAKVLKGHCE 736


>gi|11136626 NADPH oxidase 3 [Homo sapiens]
          Length = 568

 Score =  235 bits (600), Expect = 2e-61
 Identities = 157/526 (29%), Positives = 256/526 (48%), Gaps = 71/526 (13%)

Query: 1083 SRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVD----FHRWIAMAAVVLA 1138
            +R +A  ++F    IL+ + RNLI+F+R T +    P+   +D    FH+ +A    V A
Sbjct: 54   ARASALCLNFNCMLILIPVSRNLISFIRGTSICCRGPWRRQLDKNLRFHKLVAYGIAVNA 113

Query: 1139 ILHSAGHAVNVYIF----SVSPLSLLACIF-----PNV-FVNDGSKLPQKFYWWFFQTVP 1188
             +H   H  N+  +    S     LLA +      PN  ++N     P        +T+ 
Sbjct: 114  TIHIVAHFFNLERYHWSQSEEAQGLLAALSKLGNTPNESYLNPVRTFPTNTTTELLRTIA 173

Query: 1189 GMTGVLLLLVLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQ------ 1242
            G+TG+++ L L ++   ++   R+ S+  FW THH++I+ +  L IHG+  +++      
Sbjct: 174  GVTGLVISLALVLIMTSSTEFIRQASYELFWYTHHVFIVFFLSLAIHGTGRIVRGQTQDS 233

Query: 1243 ------------------------------LPTFHIYFLVPAIIYGGDKLVSLSRKKVEI 1272
                                           P+   + L P ++Y  ++++   R + E+
Sbjct: 234  LSLHNITFCRDRYAEWQTVAQCPVPQFSGKEPSAWKWILGPVVLYACERIIRFWRFQQEV 293

Query: 1273 SVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLH 1332
             + K    PSGV  L  ++ +GF+   GQ++ + C A+ + E+HPFTLTSAP ED  S+H
Sbjct: 294  VITKVVSHPSGVLELHMKK-RGFKMAPGQYILVQCPAISSLEWHPFTLTSAPQEDFFSVH 352

Query: 1333 IRAVGPWTTRLREIYSSPKGNGCA---GYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGV 1389
            IRA G WT  L E + + +G         P+L +DGPFG    +   + V V V  GIGV
Sbjct: 353  IRAAGDWTAALLEAFGA-EGQALQEPWSLPRLAVDGPFGTALTDVFHYPVCVCVAAGIGV 411

Query: 1390 TPFASILKDLVFK-SSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVE----ENDHQDL 1444
            TPFA++LK + +K S   + +   K+YF W+ R  R FEW AD++  +E    E      
Sbjct: 412  TPFAALLKSIWYKCSEAQTPLKLSKVYFYWICRDARAFEWFADLLLSLETRMSEQGKTHF 471

Query: 1445 VSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQE 1504
            +S HI++T   E   L   +      H+ +  N  + TGL+  T +GRP +   F  +  
Sbjct: 472  LSYHIFLTGWDENQALHIAL------HWDE--NTDVITGLKQKTFYGRPNWNNEFKQIAY 523

Query: 1505 VHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQD--RAHFMHHYENF 1548
             HP    IGVF CGP  +++ ++K C L +  D    HF ++ E+F
Sbjct: 524  NHPS-SSIGVFFCGPKALSRTLQKMCHLYSSADPRGVHFYYNKESF 568


>gi|6996021 cytochrome b-245 beta polypeptide [Homo sapiens]
          Length = 570

 Score =  227 bits (578), Expect = 8e-59
 Identities = 166/564 (29%), Positives = 269/564 (47%), Gaps = 82/564 (14%)

Query: 1053 VGVFADRAYYYGFASPPSDIAQTTLVG--IILSRGTAASVSFMFSYILLTMCRNLITFLR 1110
            + VF    YY  +  PP       L+G  + L+R  AA ++F    ILL +CRNL++FLR
Sbjct: 21   LNVFLFVWYYRVYDIPPKFFYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLR 80

Query: 1111 ------ETFLNRYVPFDAAVDFHRWIAMAAVVLAILHSAGHAVNV-------------YI 1151
                   T + R +  D  + FH+ +A    + + +H+  H  NV             Y 
Sbjct: 81   GSSACCSTRVRRQL--DRNLTFHKMVAWMIALHSAIHTIAHLFNVEWCVNARVNNSDPYS 138

Query: 1152 FSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLAIMYVFASHHFR 1211
             ++S L          F     K P+   +     + G+TGV++ L L ++   ++   R
Sbjct: 139  VALSELGDRQNESYLNFARKRIKNPEGGLYLAVTLLAGITGVVITLCLILIITSSTKTIR 198

Query: 1212 RRSFRGFWLTHHLYILLYALLIIHGSYALIQ----------------------------- 1242
            R  F  FW THHL+++ +  L IHG+  +++                             
Sbjct: 199  RSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLAVHNITVCEQKISEWGKIKECP 258

Query: 1243 LPTFH-------IYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGF 1295
            +P F         + + P  +Y  ++LV   R + ++ + K    P     LQ ++ +GF
Sbjct: 259  IPQFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKK-KGF 317

Query: 1296 EYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGC 1355
            + + GQ++ + C  +   E+HPFTLTSAP ED  S+HIR VG WT  L       K    
Sbjct: 318  KMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGDWTEGLFNACGCDKQEFQ 377

Query: 1356 AGY--PKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFK-SSLGSQMLCK 1412
              +  PK+ +DGPFG   ++   +EV +LVG GIGVTPFASILK + +K  +  + +  K
Sbjct: 378  DAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCNNATNLKLK 437

Query: 1413 KIYFIWVTRTQRQFEWLADIIQ----EVEENDHQDLVSVHIYVTQLAEKFDLRTTMLYIC 1468
            KIYF W+ R    FEW AD++Q    +++E ++   +S +IY+T   E     +   +  
Sbjct: 438  KIYFYWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYLTGWDE-----SQANHFA 492

Query: 1469 ERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEK 1528
              H ++   + + TGL+  T +GRP ++  F ++   HP  R IGVF CGP  + + + K
Sbjct: 493  VHHDEE---KDVITGLKQKTLYGRPNWDNEFKTIASQHPNTR-IGVFLCGPEALAETLSK 548

Query: 1529 ACQLVNRQDR----AHFMHHYENF 1548
              Q ++  +      HF+ + ENF
Sbjct: 549  --QSISNSESGPRGVHFIFNKENF 570


>gi|148536873 NADPH oxidase 1 isoform long [Homo sapiens]
          Length = 564

 Score =  224 bits (571), Expect = 5e-58
 Identities = 165/575 (28%), Positives = 272/575 (47%), Gaps = 74/575 (12%)

Query: 1034 FVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTAASVSFM 1093
            +V N+   ++ + ++  + V +F D    Y  A       +     +  +R +A  ++F 
Sbjct: 4    WVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCLNFN 63

Query: 1094 FSYILLTMCRNLITFLRET--FLNRYV--PFDAAVDFHRWIAMAAVVLAILHSAGHAVNV 1149
             + ILL +CRNL++FLR T  F +R +    D  + FH+ +A    +   +H   H  N 
Sbjct: 64   STLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHLFNF 123

Query: 1150 YIFSVSPLSL---LACIFPNV---------FVNDGSKLPQKFYWWFFQTVPGMTGVLLLL 1197
              +S S  +    LA I  ++         ++N          +  F ++ G+TGV++ +
Sbjct: 124  DCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVIMTI 183

Query: 1198 VLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPT------------ 1245
             L +M   A+   RR  F  FW THHL+I     L IHG   +++  T            
Sbjct: 184  ALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHPRKC 243

Query: 1246 ---FHIY----------------------FLVPAIIYGGDKLVSLSRKKVEISVVKAELL 1280
               F ++                       L P I+Y  ++++   R + ++ + K  + 
Sbjct: 244  AESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKVVMH 303

Query: 1281 PSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAVGPWT 1340
            PS V  LQ  + +GF  + GQ++ + C ++   E+HPFTLTSAP ED  S+HIRA G WT
Sbjct: 304  PSKVLELQMNK-RGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGDWT 362

Query: 1341 TRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLV 1400
              L   +        +  P++ +DGPFG   ++  ++EV+VLVG GIGVTPFASILK + 
Sbjct: 363  ENLIRAFEQQ----YSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIW 418

Query: 1401 FKSSLGSQML-CKKIYFIWVTRTQRQFEW----LADIIQEVEENDHQDLVSVHIYVTQLA 1455
            +K       L  KKIYF W+ R    F W    L  + QE+EE      ++  +++T   
Sbjct: 419  YKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLT--- 475

Query: 1456 EKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVF 1515
                  + ++     +F K  +  + TGL+  T FGRP ++  F+++   HP+   +GVF
Sbjct: 476  ---GWDSNIVGHAALNFDKATD--IVTGLKQKTSFGRPMWDNEFSTIATSHPK-SVVGVF 529

Query: 1516 SCGPPGMTKNVEKACQLVNRQD--RAHFMHHYENF 1548
             CGP  + K++ K C   +  D  +  F  + ENF
Sbjct: 530  LCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF 564


>gi|7669510 NADPH oxidase 1 isoform long variant [Homo sapiens]
          Length = 515

 Score =  191 bits (485), Expect = 5e-48
 Identities = 154/570 (27%), Positives = 248/570 (43%), Gaps = 113/570 (19%)

Query: 1034 FVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTAASVSFM 1093
            +V N+   ++ + ++  + V +F D    Y  A       +     +  +R +A  ++F 
Sbjct: 4    WVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCLNFN 63

Query: 1094 FSYILLTMCRNLITFLRET--FLNRYV--PFDAAVDFHRWIAMAAVVLAILHSAGHAVNV 1149
             + ILL +CRNL++FLR T  F +R +    D  + FH+ +A    +   +H   H  N 
Sbjct: 64   STLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHLFNF 123

Query: 1150 YIFSVSPLSL---LACIFPNV---------FVNDGSKLPQKFYWWFFQTVPGMTGVLLLL 1197
              +S S  +    LA I  ++         ++N          +  F ++ G+TGV++ +
Sbjct: 124  DCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVIMTI 183

Query: 1198 VLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPT------------ 1245
             L +M   A+   RR  F  FW THHL+I     L IHG   +++  T            
Sbjct: 184  ALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHPRKC 243

Query: 1246 ---FHIY----------------------FLVPAIIYGGDKLVSLSRKKVEISVVKAELL 1280
               F ++                       L P I+Y  ++++   R + ++ + K  + 
Sbjct: 244  AESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKVVMH 303

Query: 1281 PSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAVGPWT 1340
            PS V  LQ  + +GF  + GQ++ + C ++   E+HPFTLTSAP ED  S+HIRA G WT
Sbjct: 304  PSKVLELQMNK-RGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGDWT 362

Query: 1341 TRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLV 1400
              L   +        +  P++ +DGPFG   ++  ++EV+VLVG GIGVTPFASILK + 
Sbjct: 363  ENLIRAFEQQ----YSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIW 418

Query: 1401 FKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEENDHQDLVSVHIYVTQLAEKFDL 1460
            +K       L  K                                     V   A  FD 
Sbjct: 419  YKFQCADHNLKTK------------------------------------KVGHAALNFDK 442

Query: 1461 RTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPP 1520
             T                 + TGL+  T FGRP ++  F+++   HP+   +GVF CGP 
Sbjct: 443  AT----------------DIVTGLKQKTSFGRPMWDNEFSTIATSHPK-SVVGVFLCGPR 485

Query: 1521 GMTKNVEKACQLVNRQD--RAHFMHHYENF 1548
             + K++ K C   +  D  +  F  + ENF
Sbjct: 486  TLAKSLRKCCHRYSSLDPRKVQFYFNKENF 515


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score =  148 bits (374), Expect = 3e-35
 Identities = 155/543 (28%), Positives = 232/543 (42%), Gaps = 51/543 (9%)

Query: 38   YDGWFNNLRHHERGAVGCRLQRRVPANYADGVY--QALEEP-----QLPNPRRLSNAATR 90
            +DG  NNL+    GA      R +   Y DG+   + L  P      LP PR ++    R
Sbjct: 730  HDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPPRLVATVWAR 789

Query: 91   GIAGLPSLHNRTVLGVFFGYHVLSD----VVSVETP----GCPAEFLNIRIPPGDPV--- 139
              A  P  H+ T + + +G+ +  D    V ++ T     G P   +    PP  P+   
Sbjct: 790  AAAVTPD-HSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFPMNTR 848

Query: 140  -FDPDQRGDVVLPFQRSRWDPETGRSPSN-----PRDLANQVTGWLDGSAIYGSSHSWSD 193
              DP       + F RS     +GR  +       R+  NQ T ++DGS +YGSS   S 
Sbjct: 849  HADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVYGSSERESQ 908

Query: 194  ALR--SFSGGQLASGPDPAFP-RDSQNPLLMWAA--PDPATGQNGPRGLYAFGAERGNRE 248
            ALR  S   G L +G    FP   S  PLL ++   P     Q      +  G  R N  
Sbjct: 909  ALRDPSVPRGLLKTG----FPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHRANEH 964

Query: 249  PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL-- 306
              L A+  LWFR HN  A  L+  +P WE   ++Q ARK V A  Q+I    WLP  L  
Sbjct: 965  LALAAMHTLWFREHNRVATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKVLGD 1024

Query: 307  --QKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSS 364
               + L  Y GY P ++  I   F  A+ +F  T++ P +Y  NA+      +++G    
Sbjct: 1025 PGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATL---GEISEGHLPF 1081

Query: 365  QALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKFSRTD 424
                   +  I+E         V   L G+A++       ++  +L          +  D
Sbjct: 1082 HKALFSPSRIIKE----GGIDPVLRGLFGVAAK-WRAPSYLLSPELTQRLFSAAYSAAVD 1136

Query: 425  YVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNV-DPQVLEATAALYNQ--DLSQ 481
              A+ IQRGRD G+P Y    +   L   +N+ DL   + D ++ +    LY    D+  
Sbjct: 1137 SAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDL 1196

Query: 482  LELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTLR 541
               L+   L      GP    + + QF RLRDGDR+W+EN   G+F+  ++  ++  +L 
Sbjct: 1197 WPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENP--GVFTPAQLTQLKQASLS 1254

Query: 542  DVL 544
             VL
Sbjct: 1255 RVL 1257


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score =  145 bits (365), Expect = 4e-34
 Identities = 153/568 (26%), Positives = 241/568 (42%), Gaps = 98/568 (17%)

Query: 38   YDGWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPS 97
            +DG  NNL+H   GA     +R + + Y +G       P+  NP RL N        +P 
Sbjct: 744  HDGTCNNLQHPMWGASLTAFERLLKSVYENG----FNTPRGINPHRLYNGHA---LPMPR 796

Query: 98   LHNRTVLGV------------------FFGYHVLSDVVSVET----------------PG 123
            L + T++G                   F  + + S VV++                  P 
Sbjct: 797  LVSTTLIGTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCSNDPP 856

Query: 124  CPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSN-------PRDLANQVT 176
            C     ++ IPP D      + G   + F RS   P  G   ++       PR+  NQ+T
Sbjct: 857  C----FSVMIPPND---SRARSGARCMFFVRS--SPVCGSGMTSLLMNSVYPREQINQLT 907

Query: 177  GWLDGSAIYGSSHSWSDALRSFSG--GQLASGPDPAFPRDSQNPLLMWAAPDPAT----G 230
             ++D S +YGS+   + ++R  +   G L  G      + S  PLL +A   P       
Sbjct: 908  SYIDASNVYGSTEHEARSIRDLASHRGLLRQG----IVQRSGKPLLPFATGPPTECMRDE 963

Query: 231  QNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVI 290
               P   +  G  R N +  L ++  LWFR HN  A  L + +P W+ + ++   RK V 
Sbjct: 964  NESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVG 1023

Query: 291  ATYQNIAVYEWLPSFL----QKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYM 346
            A  Q+I    WLP  L     +TL EY GY P ++  I   F  A+ +F  T+V P +Y 
Sbjct: 1024 AEIQHITYQHWLPKILGEVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPLLYR 1083

Query: 347  RNASCHFRKV------LNKGFQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISE 400
             +   +F+ +      L+K F S    R+ N   I  +P L         L G+A ++  
Sbjct: 1084 LDE--NFQPIAQDHLPLHKAFFS--PFRIVNEGGI--DPLLRG-------LFGVAGKM-R 1129

Query: 401  LEDNIVVEDLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLN 460
            +   ++  +L +           D  A +IQRGRD G+P Y    +   L     + DL 
Sbjct: 1130 VPSQLLNTELTERLFSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLK 1189

Query: 461  PNV-DPQVLEATAALYNQDLSQLELLLGGLLES---HGDPGPLFSAIVLDQFVRLRDGDR 516
              + +P++ E    LY   L+ ++L    ++E        GP    ++  QF RLRDGDR
Sbjct: 1190 NEIKNPEIREKLKRLYGSTLN-IDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDR 1248

Query: 517  YWFENTRNGLFSKKEIEDIRNTTLRDVL 544
             W+EN   G+FS  ++  I+ T+L  +L
Sbjct: 1249 LWYENP--GVFSPAQLTQIKQTSLARIL 1274


>gi|219842348 NADPH oxidase 4 isoform c [Homo sapiens]
          Length = 554

 Score =  144 bits (364), Expect = 5e-34
 Identities = 92/319 (28%), Positives = 154/319 (48%), Gaps = 36/319 (11%)

Query: 1244 PTFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWV 1303
            P   ++   P  +Y  ++L    R    ++++     PS V  ++  + + F+ + GQ++
Sbjct: 257  PQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVISHPSDVMEIRMVK-ENFKARPGQYI 315

Query: 1304 RIACLALGTTEYHPFTLTSAPHED--TLSLHIRAVGPWTTRLREIYSSPKGNGCA----- 1356
             + C ++   E HPFTLT  P E   T  +H++ VG WT R R++   P           
Sbjct: 316  TLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFI 375

Query: 1357 ---GYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKK 1413
                YPKLY+DGPFG   +E   +EVS+ V GGIGVTPFASIL  L+           ++
Sbjct: 376  QSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLL---DDWKPYKLRR 432

Query: 1414 IYFIWVTRTQRQFEWLADII----QEVEENDHQDLVSVHIYVTQLAEKFDLRTTMLYICE 1469
            +YFIWV R  + F W AD++     +  + +  D V++ +Y++Q                
Sbjct: 433  LYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQ---------------T 477

Query: 1470 RHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKA 1529
               QK++    +  L S    GRP ++  F+ + + + + + +GVF CGP  ++K + K 
Sbjct: 478  DGIQKIIGEK-YHALNSRLFIGRPRWKLLFDEIAK-YNRGKTVGVFCCGPNSLSKTLHKL 535

Query: 1530 CQLVNRQDRAHFMHHYENF 1548
                N      F ++ E+F
Sbjct: 536  SN-QNNSYGTRFEYNKESF 553



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 54/175 (30%), Positives = 91/175 (52%), Gaps = 16/175 (9%)

Query: 1078 VGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVP-------FDAAVDFHRWI 1130
            +G+ LSR +A+ ++   S ILL MCR L+ +LR +   + VP        D +  FH   
Sbjct: 28   LGLCLSRASASVLNLNCSLILLPMCRTLLAYLRGS---QKVPSRRTRRLLDKSRTFHITC 84

Query: 1131 AMAAVVLAILHSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGM 1190
             +   + + +H A H VN   FSV+       +    + ++    P+K     F TVPG+
Sbjct: 85   GVTICIFSGVHVAAHLVNALNFSVNYSEDFVELNAARYRDED---PRKL---LFTTVPGL 138

Query: 1191 TGVLLLLVLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPT 1245
            TGV +++VL +M   +++  R  ++  FW TH+L+ + Y LL +H S  L++  T
Sbjct: 139  TGVCMVVVLFLMITASTYAIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQT 193


>gi|8393843 NADPH oxidase 4 isoform a [Homo sapiens]
          Length = 578

 Score =  144 bits (364), Expect = 5e-34
 Identities = 92/319 (28%), Positives = 154/319 (48%), Gaps = 36/319 (11%)

Query: 1244 PTFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWV 1303
            P   ++   P  +Y  ++L    R    ++++     PS V  ++  + + F+ + GQ++
Sbjct: 281  PQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVISHPSDVMEIRMVK-ENFKARPGQYI 339

Query: 1304 RIACLALGTTEYHPFTLTSAPHED--TLSLHIRAVGPWTTRLREIYSSPKGNGCA----- 1356
             + C ++   E HPFTLT  P E   T  +H++ VG WT R R++   P           
Sbjct: 340  TLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFI 399

Query: 1357 ---GYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKK 1413
                YPKLY+DGPFG   +E   +EVS+ V GGIGVTPFASIL  L+           ++
Sbjct: 400  QSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLL---DDWKPYKLRR 456

Query: 1414 IYFIWVTRTQRQFEWLADII----QEVEENDHQDLVSVHIYVTQLAEKFDLRTTMLYICE 1469
            +YFIWV R  + F W AD++     +  + +  D V++ +Y++Q                
Sbjct: 457  LYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQ---------------T 501

Query: 1470 RHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKA 1529
               QK++    +  L S    GRP ++  F+ + + + + + +GVF CGP  ++K + K 
Sbjct: 502  DGIQKIIGEK-YHALNSRLFIGRPRWKLLFDEIAK-YNRGKTVGVFCCGPNSLSKTLHKL 559

Query: 1530 CQLVNRQDRAHFMHHYENF 1548
                N      F ++ E+F
Sbjct: 560  SN-QNNSYGTRFEYNKESF 577



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 60/210 (28%), Positives = 104/210 (49%), Gaps = 16/210 (7%)

Query: 1043 VCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTAASVSFMFSYILLTMC 1102
            +C+ I+ ++ V +F      Y        + Q   +G+ LSR +A+ ++   S ILL MC
Sbjct: 17   LCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMC 76

Query: 1103 RNLITFLRETFLNRYVP-------FDAAVDFHRWIAMAAVVLAILHSAGHAVNVYIFSVS 1155
            R L+ +LR +   + VP        D +  FH    +   + + +H A H VN   FSV+
Sbjct: 77   RTLLAYLRGS---QKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHVAAHLVNALNFSVN 133

Query: 1156 PLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLAIMYVFASHHFRRRSF 1215
                   +    + ++    P+K     F TVPG+TGV +++VL +M   +++  R  ++
Sbjct: 134  YSEDFVELNAARYRDED---PRKL---LFTTVPGLTGVCMVVVLFLMITASTYAIRVSNY 187

Query: 1216 RGFWLTHHLYILLYALLIIHGSYALIQLPT 1245
              FW TH+L+ + Y LL +H S  L++  T
Sbjct: 188  DIFWYTHNLFFVFYMLLTLHVSGGLLKYQT 217


>gi|4503595 eosinophil peroxidase [Homo sapiens]
          Length = 715

 Score =  124 bits (311), Expect = 7e-28
 Identities = 149/546 (27%), Positives = 240/546 (43%), Gaps = 61/546 (11%)

Query: 40  GWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRR------LSNAATRGIA 93
           G  NN R    GA    L R +PA Y DG+  +L     P+ RR      L  A +  I 
Sbjct: 150 GRCNNKRRPLLGASNQALARWLPAEYEDGL--SLPFGWTPSRRRNGFLLPLVRAVSNQIV 207

Query: 94  GLP-----SLHNRTVLGVFFGYHVLSDV-VSVETPGCPA---------------EFLNIR 132
             P     S   R ++ + +G  +  D+  S E+P   A                   I+
Sbjct: 208 RFPNERLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFTAGVDCERTCAQLPPCFPIK 267

Query: 133 IPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWS 192
           IPP DP    +QR    +PF RS   P   ++ +  R+  N +T ++D S +YGS  S S
Sbjct: 268 IPPNDPRIK-NQRD--CIPFFRSA--PSCPQNKNRVRNQINALTSFVDASMVYGSEVSLS 322

Query: 193 DALRSFSGGQLASGPDPAFPRDSQNPLLMW--AAPDPATGQNGPRGLYAF--GAERGNRE 248
             LR+ +        +  F +D+   LL +     DP    N    +  F  G  R    
Sbjct: 323 LRLRNRTNYLGLLAINQRF-QDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSTET 381

Query: 249 PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL-- 306
           P L A+  L+ R HN  A  L R +P W  ++L+  ARK + A  Q I   ++LP  L  
Sbjct: 382 PKLAAMHTLFMREHNRLATELRRLNPRWNGDKLYNEARKIMGAMVQIITYRDFLPLVLGK 441

Query: 307 ---QKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQS 363
              ++TL  Y GY   +DP ++  F +A  +F  TM+ P ++ R  S +     N     
Sbjct: 442 ARARRTLGHYRGYCSNVDPRVANVFTLAF-RFGHTMLQPFMF-RLDSQYRASAPNSHVPL 499

Query: 364 SQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISEL--EDNIVVEDLRDYWPGPGKFS 421
           S A       W      +     ++ +L G+ +  ++L  +D ++V++LRD      +  
Sbjct: 500 SSAFFAS---W-----RIVYEGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFRQVRRI 551

Query: 422 RTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLSQ 481
             D  A ++QR RD GLP Y+      GL  PRN + L+  +  Q L             
Sbjct: 552 GLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLNLYGTPDN 611

Query: 482 LELLLGGLLE---SHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNT 538
           +++ +G + E        GPL + +  +QF R RDGDR+W++  + G+F+K++ + +   
Sbjct: 612 IDIWIGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWWQ--KRGVFTKRQRKALSRI 669

Query: 539 TLRDVL 544
           +L  ++
Sbjct: 670 SLSRII 675


>gi|28558982 thyroid peroxidase isoform a [Homo sapiens]
          Length = 933

 Score =  120 bits (300), Expect = 1e-26
 Identities = 118/430 (27%), Positives = 191/430 (44%), Gaps = 48/430 (11%)

Query: 146 GDVVLPFQRSRWDPETGR--------SPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRS 197
           G   LPF RS     TG         S +NPR   N +T +LD S +YGSS +    LR+
Sbjct: 283 GTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRN 342

Query: 198 FSGGQLASGPDPAFPRDSQNPLLMWA--------APDPATGQNGPRGLYAFGAERGNREP 249
           ++  +          RDS    L +         AP+P          +  G  R +  P
Sbjct: 343 WTSAEGLLRVHARL-RDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVP 401

Query: 250 FLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL--- 306
            L AL  LW R HN  A  L   +  W  + ++Q ARK V A +Q I + +++P  L   
Sbjct: 402 SLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPE 461

Query: 307 --QKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSS 364
             Q+ +  Y GY    +P++S  F  A+ +F    + P V   +AS          FQ  
Sbjct: 462 AFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDAS----------FQEH 511

Query: 365 QALRVCNNYWIRE---NP-NLNSTQEVNELLLGMASQISEL--EDNIVVEDLRDYWPGPG 418
             L      W+ +   +P  L     ++ L+ G+ ++ ++L  +D ++ E+L +      
Sbjct: 512 PDL---PGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLS 568

Query: 419 KFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNV-DPQVLEATAALYNQ 477
             S  D  + ++QRGRD GLP Y++     GL      +DL+  +    V +    LY  
Sbjct: 569 NSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKH 628

Query: 478 DLSQLELLLGGLLES---HGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIED 534
               +++ LGGL E+       GPLF+ ++  Q   LRDGD +W+EN+   +F+  +  +
Sbjct: 629 P-DNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSH--VFTDAQRRE 685

Query: 535 IRNTTLRDVL 544
           +   +L  V+
Sbjct: 686 LEKHSLSRVI 695


>gi|28558988 thyroid peroxidase isoform d [Homo sapiens]
          Length = 889

 Score =  120 bits (300), Expect = 1e-26
 Identities = 118/430 (27%), Positives = 191/430 (44%), Gaps = 48/430 (11%)

Query: 146 GDVVLPFQRSRWDPETGR--------SPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRS 197
           G   LPF RS     TG         S +NPR   N +T +LD S +YGSS +    LR+
Sbjct: 283 GTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRN 342

Query: 198 FSGGQLASGPDPAFPRDSQNPLLMWA--------APDPATGQNGPRGLYAFGAERGNREP 249
           ++  +          RDS    L +         AP+P          +  G  R +  P
Sbjct: 343 WTSAEGLLRVHARL-RDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVP 401

Query: 250 FLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL--- 306
            L AL  LW R HN  A  L   +  W  + ++Q ARK V A +Q I + +++P  L   
Sbjct: 402 SLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPE 461

Query: 307 --QKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSS 364
             Q+ +  Y GY    +P++S  F  A+ +F    + P V   +AS          FQ  
Sbjct: 462 AFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDAS----------FQEH 511

Query: 365 QALRVCNNYWIRE---NP-NLNSTQEVNELLLGMASQISEL--EDNIVVEDLRDYWPGPG 418
             L      W+ +   +P  L     ++ L+ G+ ++ ++L  +D ++ E+L +      
Sbjct: 512 PDL---PGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLS 568

Query: 419 KFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNV-DPQVLEATAALYNQ 477
             S  D  + ++QRGRD GLP Y++     GL      +DL+  +    V +    LY  
Sbjct: 569 NSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKH 628

Query: 478 DLSQLELLLGGLLES---HGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIED 534
               +++ LGGL E+       GPLF+ ++  Q   LRDGD +W+EN+   +F+  +  +
Sbjct: 629 P-DNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSH--VFTDAQRRE 685

Query: 535 IRNTTLRDVL 544
           +   +L  V+
Sbjct: 686 LEKHSLSRVI 695


>gi|231569458 lactoperoxidase isoform 3 preproprotein [Homo sapiens]
          Length = 629

 Score =  119 bits (298), Expect = 2e-26
 Identities = 154/594 (25%), Positives = 250/594 (42%), Gaps = 92/594 (15%)

Query: 8   ALMLLGALLTGSLGPSGNQDALSL------PWEVQRYD---------GWFNNLRHHERGA 52
           +L+LL A  + +  PS +  +LSL      P  V R D         G  NN R    GA
Sbjct: 13  SLILLQAAASTTRDPSLDLTSLSLEVGCGAPAPVVRCDPCSPYRTITGDCNNRRKPALGA 72

Query: 53  VGCRLQRRVPANYADGVY--------QALEEPQLPNPRRLSNAATRGIAGLPSL-HNRTV 103
               L R +PA Y DG+         +      LP  R +SN     +     L  NR++
Sbjct: 73  ANRALARWLPAEYEDGLSLPFGWTPGKTRNGFPLPLAREVSNKIVGYLNEEGVLDQNRSL 132

Query: 104 LGVFFGYHVLSDV-VSVETPGCPAEFLN---------------IRIPPGDPVFDPDQRGD 147
           L + +G  V  D+  + +T    +E+                 I  PP DP      +  
Sbjct: 133 LFMQWGQIVDHDLDFAPDTELGSSEYSKAQCDEYCIQGDNCFPIMFPPNDPKAGTQGK-- 190

Query: 148 VVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSG--GQLAS 205
             +PF R+ +   T    S  R+  N +T +LD S +Y S  S +  LR+ S   G +A 
Sbjct: 191 -CMPFFRAGFVCPTPPYKSLAREQINALTSFLDASFVYSSEPSLASRLRNLSSPLGLMAV 249

Query: 206 GPD------PAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWF 259
             +      P  P DS+ P     +P            +  G  R +    L     L+ 
Sbjct: 250 NQEVSDHGLPYLPYDSKKP-----SPCEFINTTARVPCFLAGDSRASEHILLATSHTLFL 304

Query: 260 RYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL----QKTLPEYTG 315
           R HN  A+ L R +P W+ E+L+Q ARK + A  Q I   ++LP  L    QK +P Y G
Sbjct: 305 REHNRLARELKRLNPQWDGEKLYQEARKILGAFVQIITFRDYLPILLGDHMQKWIPPYQG 364

Query: 316 YRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQ------SSQALRV 369
           Y   +DP IS  F  A  +F    VP  ++           L++ +Q            +
Sbjct: 365 YSESVDPRISNVFTFAF-RFGHLEVPSSMFR----------LDENYQPWGPEPELPLHTL 413

Query: 370 CNNYWIRENPNLNSTQEVNELLLGMASQISEL--EDNIVVEDLRDYWPGP-GKFSRTDYV 426
             N W      +     ++ L+ G+ ++ S+L  ++ ++  +LR+    P  +    D  
Sbjct: 414 FFNTW-----RMVKDGGIDPLVRGLLAKKSKLMKQNKMMTGELRNKLFQPTHRIHGFDLA 468

Query: 427 ASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVL-EATAALYNQDLSQLELL 485
           A + QR RD G P Y+       L  P+   +LN  +  ++L +    LY      +++ 
Sbjct: 469 AINTQRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKKLLGLYGTP-DNIDIW 527

Query: 486 LGGLLE---SHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIR 536
           +G + E     G  GPL + ++  QF ++RDGDR+W+EN   G+F+ ++ + ++
Sbjct: 528 IGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENP--GVFTNEQKDSLQ 579


>gi|40549418 lactoperoxidase isoform 1 preproprotein [Homo sapiens]
          Length = 712

 Score =  117 bits (294), Expect = 7e-26
 Identities = 153/588 (26%), Positives = 245/588 (41%), Gaps = 92/588 (15%)

Query: 14  ALLTGSLGPSGNQDALSL------PWEVQRYD---------GWFNNLRHHERGAVGCRLQ 58
           A LT    PS +  +LSL      P  V R D         G  NN R    GA    L 
Sbjct: 102 ASLTNVTDPSLDLTSLSLEVGCGAPAPVVRCDPCSPYRTITGDCNNRRKPALGAANRALA 161

Query: 59  RRVPANYADGVY--------QALEEPQLPNPRRLSNAATRGIAGLPSL-HNRTVLGVFFG 109
           R +PA Y DG+         +      LP  R +SN     +     L  NR++L + +G
Sbjct: 162 RWLPAEYEDGLSLPFGWTPGKTRNGFPLPLAREVSNKIVGYLNEEGVLDQNRSLLFMQWG 221

Query: 110 YHVLSDV-VSVETPGCPAEFLN---------------IRIPPGDPVFDPDQRGDVVLPFQ 153
             V  D+  + +T    +E+                 I  PP DP      +    +PF 
Sbjct: 222 QIVDHDLDFAPDTELGSSEYSKAQCDEYCIQGDNCFPIMFPPNDPKAGTQGK---CMPFF 278

Query: 154 RSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSG--GQLASGPD--- 208
           R+ +   T    S  R+  N +T +LD S +Y S  S +  LR+ S   G +A   +   
Sbjct: 279 RAGFVCPTPPYKSLAREQINALTSFLDASFVYSSEPSLASRLRNLSSPLGLMAVNQEVSD 338

Query: 209 ---PAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLW 265
              P  P DS+ P     +P            +  G  R +    L     L+ R HN  
Sbjct: 339 HGLPYLPYDSKKP-----SPCEFINTTARVPCFLAGDSRASEHILLATSHTLFLREHNRL 393

Query: 266 AQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL----QKTLPEYTGYRPFLD 321
           A+ L R +P W+ E+L+Q ARK + A  Q I   ++LP  L    QK +P Y GY   +D
Sbjct: 394 ARELKRLNPQWDGEKLYQEARKILGAFVQIITFRDYLPILLGDHMQKWIPPYQGYSESVD 453

Query: 322 PSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQ------SSQALRVCNNYWI 375
           P IS  F  A  +F    VP  ++           L++ +Q            +  N W 
Sbjct: 454 PRISNVFTFAF-RFGHLEVPSSMFR----------LDENYQPWGPEPELPLHTLFFNTW- 501

Query: 376 RENPNLNSTQEVNELLLGMASQISEL--EDNIVVEDLRDYWPGP-GKFSRTDYVASSIQR 432
                +     ++ L+ G+ ++ S+L  ++ ++  +LR+    P  +    D  A + QR
Sbjct: 502 ----RMVKDGGIDPLVRGLLAKKSKLMKQNKMMTGELRNKLFQPTHRIHGFDLAAINTQR 557

Query: 433 GRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVL-EATAALYNQDLSQLELLLGGLLE 491
            RD G P Y+       L  P+   +LN  +  ++L +    LY      +++ +G + E
Sbjct: 558 CRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKKLLGLYGTP-DNIDIWIGAIAE 616

Query: 492 ---SHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIR 536
                G  GPL + ++  QF ++RDGDR+W+EN   G+F+ ++ + ++
Sbjct: 617 PLVERGRVGPLLACLLGKQFQQIRDGDRFWWENP--GVFTNEQKDSLQ 662


>gi|4557759 myeloperoxidase [Homo sapiens]
          Length = 745

 Score =  115 bits (287), Expect = 4e-25
 Identities = 142/559 (25%), Positives = 232/559 (41%), Gaps = 87/559 (15%)

Query: 40  GWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRR------LSNAATRGIA 93
           G  NN R    GA      R +PA Y DG   +L     P  +R      L+ A +  I 
Sbjct: 178 GMCNNRRSPTLGASNRAFVRWLPAEYEDGF--SLPYGWTPGVKRNGFPVALARAVSNEIV 235

Query: 94  GLPSLH-----NRTVLGVFFGYHVLSDVVSVETPGCPAEFLN----------------IR 132
             P+        R+++ + +G  +  D+     P   A F+                 ++
Sbjct: 236 RFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLK 295

Query: 133 IPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWS 192
           IPP DP      + D + PF RS   P    S    R+  N +T ++D S +YGS    +
Sbjct: 296 IPPNDPRIK--NQADCI-PFFRSC--PACPGSNITIRNQINALTSFVDASMVYGSEEPLA 350

Query: 193 DALRSFSGGQLASGPDPAFPRDSQNPLLMW--AAPDPATGQNGPRGLYAF--GAERGNRE 248
             LR+ S        +  F +D+   LL +     DP    N    +  F  G  R +  
Sbjct: 351 RNLRNMSNQLGLLAVNQRF-QDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEM 409

Query: 249 PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWL-----P 303
           P L ++  L  R HN  A  L   +P W+ E L+Q ARK V A  Q I   ++L     P
Sbjct: 410 PELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGP 469

Query: 304 SFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQS 363
           + ++K LP Y  Y   +DP I+  F  A  ++  T++ P ++                  
Sbjct: 470 TAMRKYLPTYRSYNDSVDPRIANVFTNAF-RYGHTLIQPFMF------------------ 510

Query: 364 SQALRVCNNYWIRE-NPNLNSTQ------------EVNELLLGMASQISEL--EDNIVVE 408
               R+ N Y   E NP +  ++             ++ +L G+ +  ++L  ++ I V+
Sbjct: 511 ----RLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVD 566

Query: 409 DLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVL 468
           ++R+           D  A ++QR RD GLP Y+      GL  P     L   +    L
Sbjct: 567 EIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKL 626

Query: 469 EATAALYNQDLSQLELLLGGL---LESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNG 525
                      + +++ +GG+   L+  G  GPL + I+  QF +LRDGDR+W+EN   G
Sbjct: 627 ARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWEN--EG 684

Query: 526 LFSKKEIEDIRNTTLRDVL 544
           +FS ++ + +   +L  ++
Sbjct: 685 VFSMQQRQALAQISLPRII 703


>gi|219842346 NADPH oxidase 4 isoform b [Homo sapiens]
          Length = 538

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 68/319 (21%), Positives = 129/319 (40%), Gaps = 76/319 (23%)

Query: 1244 PTFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWV 1303
            P   ++   P  +Y  ++L    R    ++++     PS V  ++  + + F+ + GQ++
Sbjct: 281  PQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVISHPSDVMEIRMVK-ENFKARPGQYI 339

Query: 1304 RIACLALGTTEYHPFTLTSAPHED--TLSLHIRAVGPWTTRLREIYSSPKGNG------- 1354
             + C ++   E HPFTLT  P E   T  +H++ VG WT R R++   P           
Sbjct: 340  TLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFI 399

Query: 1355 -CAGYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKK 1413
                YPK            +W  +++                                ++
Sbjct: 400  QSRNYPK-----------DDWKPYKL--------------------------------RR 416

Query: 1414 IYFIWVTRTQRQFEWLADII----QEVEENDHQDLVSVHIYVTQLAEKFDLRTTMLYICE 1469
            +YFIWV R  + F W AD++     +  + +  D V++ +Y++Q                
Sbjct: 417  LYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQ---------------T 461

Query: 1470 RHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKA 1529
               QK++    +  L S    GRP ++  F+ + + + + + +GVF CGP  ++K + K 
Sbjct: 462  DGIQKIIGEK-YHALNSRLFIGRPRWKLLFDEIAK-YNRGKTVGVFCCGPNSLSKTLHKL 519

Query: 1530 CQLVNRQDRAHFMHHYENF 1548
                N      F ++ E+F
Sbjct: 520  SN-QNNSYGTRFEYNKESF 537



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 60/210 (28%), Positives = 104/210 (49%), Gaps = 16/210 (7%)

Query: 1043 VCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTAASVSFMFSYILLTMC 1102
            +C+ I+ ++ V +F      Y        + Q   +G+ LSR +A+ ++   S ILL MC
Sbjct: 17   LCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMC 76

Query: 1103 RNLITFLRETFLNRYVP-------FDAAVDFHRWIAMAAVVLAILHSAGHAVNVYIFSVS 1155
            R L+ +LR +   + VP        D +  FH    +   + + +H A H VN   FSV+
Sbjct: 77   RTLLAYLRGS---QKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHVAAHLVNALNFSVN 133

Query: 1156 PLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLAIMYVFASHHFRRRSF 1215
                   +    + ++    P+K     F TVPG+TGV +++VL +M   +++  R  ++
Sbjct: 134  YSEDFVELNAARYRDED---PRKL---LFTTVPGLTGVCMVVVLFLMITASTYAIRVSNY 187

Query: 1216 RGFWLTHHLYILLYALLIIHGSYALIQLPT 1245
              FW TH+L+ + Y LL +H S  L++  T
Sbjct: 188  DIFWYTHNLFFVFYMLLTLHVSGGLLKYQT 217


>gi|28558984 thyroid peroxidase isoform b [Homo sapiens]
          Length = 876

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 67/226 (29%), Positives = 98/226 (43%), Gaps = 22/226 (9%)

Query: 146 GDVVLPFQRSRWDPETGR--------SPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRS 197
           G   LPF RS     TG         S +NPR   N +T +LD S +YGSS +    LR+
Sbjct: 283 GTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRN 342

Query: 198 FSGGQLASGPDPAFPRDSQNPLLMWA--------APDPATGQNGPRGLYAFGAERGNREP 249
           ++  +          RDS    L +         AP+P          +  G  R +  P
Sbjct: 343 WTSAEGLLRVHARL-RDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVP 401

Query: 250 FLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL--- 306
            L AL  LW R HN  A  L   +  W  + ++Q ARK V A +Q I + +++P  L   
Sbjct: 402 SLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPE 461

Query: 307 --QKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNAS 350
             Q+ +  Y GY    +P++S  F  A+ +F    + P V   +AS
Sbjct: 462 AFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDAS 507


>gi|40254415 guanylate cyclase activator 1A (retina) [Homo sapiens]
          Length = 201

 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 40/125 (32%), Positives = 65/125 (52%), Gaps = 6/125 (4%)

Query: 805 ELSRAEFAESLGLK----PQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEDKS 860
           +L+  EF +  GLK        +VE MF   D + +GY+ F E++  L + +KG  E K 
Sbjct: 33  QLTLYEFRQFFGLKNLSPSASQYVEQMFETFDFNKDGYIDFMEYVAALSLVLKGKVEQKL 92

Query: 861 RLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLA-EVVESMFRESGFQDKEEL 919
           R  F +YD+D NG + +DE  T++++ I   N C      A E  +++F +       EL
Sbjct: 93  RWYFKLYDVDGNGCIDRDELLTIIQA-IRAINPCSDTTMTAEEFTDTVFSKIDVNGDGEL 151

Query: 920 TWEDF 924
           + E+F
Sbjct: 152 SLEEF 156


>gi|28558990 thyroid peroxidase isoform e [Homo sapiens]
          Length = 760

 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 65/252 (25%), Positives = 117/252 (46%), Gaps = 26/252 (10%)

Query: 303 PSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQ 362
           P   Q+ +  Y GY    +P++S  F  A+ +F    + P V   +AS          FQ
Sbjct: 287 PEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDAS----------FQ 336

Query: 363 SSQALRVCNNYWIRE---NP-NLNSTQEVNELLLGMASQISELE--DNIVVEDLRDYWPG 416
               L      W+ +   +P  L     ++ L+ G+ ++ ++L+  D ++ E+L +    
Sbjct: 337 EHPDLP---GLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFV 393

Query: 417 PGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQ-VLEATAALY 475
               S  D  + ++QRGRD GLP Y++     GL      +DL+  +  + V +    LY
Sbjct: 394 LSNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLY 453

Query: 476 NQDLSQLELLLGGLLES---HGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEI 532
                 +++ LGGL E+       GPLF+ ++  Q   LRDGD +W+EN+   +F+  + 
Sbjct: 454 KHP-DNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSH--VFTDAQR 510

Query: 533 EDIRNTTLRDVL 544
            ++   +L  V+
Sbjct: 511 RELEKHSLSRVI 522


>gi|4506025 protein phosphatase 3, regulatory subunit B, alpha
           isoform 1 [Homo sapiens]
          Length = 170

 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 37/120 (30%), Positives = 65/120 (54%), Gaps = 5/120 (4%)

Query: 806 LSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVF-MKGSPEDKSRLMF 864
           LS  EF  SL    Q+  V+ +  + D DGNG + F+EF++ +  F +KG  E K R  F
Sbjct: 38  LSVEEFM-SLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAF 96

Query: 865 TMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDF 924
            +YD+D++G++S  E F +++  +    N L   QL ++V+     +       +++E+F
Sbjct: 97  RIYDMDKDGYISNGELFQVLKMMV---GNNLKDTQLQQIVDKTIINADKDGDGRISFEEF 153


>gi|13375787 EF-hand calcium binding domain 1 isoform a [Homo
           sapiens]
          Length = 211

 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 44/142 (30%), Positives = 72/142 (50%), Gaps = 18/142 (12%)

Query: 799 REALTCELSRAEFAESLGLK---PQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGS 855
           R+ L   L R  F   L +      DM ++ +F   DKD +G ++  E++  L +F++GS
Sbjct: 41  RQGLVVGLDRNAFRNILHVTFGMTDDMIMDRVFRGFDKDNDGCVNVLEWIHGLSLFLRGS 100

Query: 856 PEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQD 915
            E+K +  F ++DL+ +GF+SK+E F M++       N L K    E       + G +D
Sbjct: 101 LEEKMKYCFEVFDLNGDGFISKEEMFHMLK-------NSLLKQPSEE-----DPDEGIKD 148

Query: 916 KEELTWEDFHFMLRDHDSELRF 937
             E+T +    M  DHD +L F
Sbjct: 149 LVEITLKK---MDHDHDGKLSF 167


>gi|98985795 neurocalcin delta [Homo sapiens]
          Length = 193

 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 8/150 (5%)

Query: 798 VREALTCELSRAEFAESLG----LKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMK 853
           +R+  +  LS  EF +  G          F E +F   D +G+G + FREF+  L V  +
Sbjct: 35  LRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALSVTSR 94

Query: 854 GSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCL----SKAQLAEVVESMFR 909
           G  E K +  F+MYDLD NG++SK E   ++++  ++ ++ +     ++   +  E +FR
Sbjct: 95  GKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFR 154

Query: 910 ESGFQDKEELTWEDFHFMLRDHDSELRFTQ 939
           +       +L+ E+F    +   S +R  Q
Sbjct: 155 QMDTNRDGKLSLEEFIRGAKSDPSIVRLLQ 184


>gi|98985793 neurocalcin delta [Homo sapiens]
          Length = 193

 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 8/150 (5%)

Query: 798 VREALTCELSRAEFAESLG----LKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMK 853
           +R+  +  LS  EF +  G          F E +F   D +G+G + FREF+  L V  +
Sbjct: 35  LRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALSVTSR 94

Query: 854 GSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCL----SKAQLAEVVESMFR 909
           G  E K +  F+MYDLD NG++SK E   ++++  ++ ++ +     ++   +  E +FR
Sbjct: 95  GKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFR 154

Query: 910 ESGFQDKEELTWEDFHFMLRDHDSELRFTQ 939
           +       +L+ E+F    +   S +R  Q
Sbjct: 155 QMDTNRDGKLSLEEFIRGAKSDPSIVRLLQ 184


>gi|98985791 neurocalcin delta [Homo sapiens]
          Length = 193

 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 8/150 (5%)

Query: 798 VREALTCELSRAEFAESLG----LKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMK 853
           +R+  +  LS  EF +  G          F E +F   D +G+G + FREF+  L V  +
Sbjct: 35  LRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALSVTSR 94

Query: 854 GSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCL----SKAQLAEVVESMFR 909
           G  E K +  F+MYDLD NG++SK E   ++++  ++ ++ +     ++   +  E +FR
Sbjct: 95  GKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFR 154

Query: 910 ESGFQDKEELTWEDFHFMLRDHDSELRFTQ 939
           +       +L+ E+F    +   S +R  Q
Sbjct: 155 QMDTNRDGKLSLEEFIRGAKSDPSIVRLLQ 184


>gi|98985789 neurocalcin delta [Homo sapiens]
          Length = 193

 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 8/150 (5%)

Query: 798 VREALTCELSRAEFAESLG----LKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMK 853
           +R+  +  LS  EF +  G          F E +F   D +G+G + FREF+  L V  +
Sbjct: 35  LRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALSVTSR 94

Query: 854 GSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCL----SKAQLAEVVESMFR 909
           G  E K +  F+MYDLD NG++SK E   ++++  ++ ++ +     ++   +  E +FR
Sbjct: 95  GKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFR 154

Query: 910 ESGFQDKEELTWEDFHFMLRDHDSELRFTQ 939
           +       +L+ E+F    +   S +R  Q
Sbjct: 155 QMDTNRDGKLSLEEFIRGAKSDPSIVRLLQ 184


>gi|98985787 neurocalcin delta [Homo sapiens]
          Length = 193

 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 8/150 (5%)

Query: 798 VREALTCELSRAEFAESLG----LKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMK 853
           +R+  +  LS  EF +  G          F E +F   D +G+G + FREF+  L V  +
Sbjct: 35  LRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALSVTSR 94

Query: 854 GSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCL----SKAQLAEVVESMFR 909
           G  E K +  F+MYDLD NG++SK E   ++++  ++ ++ +     ++   +  E +FR
Sbjct: 95  GKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFR 154

Query: 910 ESGFQDKEELTWEDFHFMLRDHDSELRFTQ 939
           +       +L+ E+F    +   S +R  Q
Sbjct: 155 QMDTNRDGKLSLEEFIRGAKSDPSIVRLLQ 184


>gi|98985785 neurocalcin delta [Homo sapiens]
          Length = 193

 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 8/150 (5%)

Query: 798 VREALTCELSRAEFAESLG----LKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMK 853
           +R+  +  LS  EF +  G          F E +F   D +G+G + FREF+  L V  +
Sbjct: 35  LRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALSVTSR 94

Query: 854 GSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCL----SKAQLAEVVESMFR 909
           G  E K +  F+MYDLD NG++SK E   ++++  ++ ++ +     ++   +  E +FR
Sbjct: 95  GKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFR 154

Query: 910 ESGFQDKEELTWEDFHFMLRDHDSELRFTQ 939
           +       +L+ E+F    +   S +R  Q
Sbjct: 155 QMDTNRDGKLSLEEFIRGAKSDPSIVRLLQ 184


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.139    0.433 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,572,378
Number of Sequences: 37866
Number of extensions: 3168351
Number of successful extensions: 9531
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 98
Number of HSP's successfully gapped in prelim test: 53
Number of HSP's that attempted gapping in prelim test: 9140
Number of HSP's gapped (non-prelim): 289
length of query: 1548
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1433
effective length of database: 13,892,928
effective search space: 19908565824
effective search space used: 19908565824
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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