BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|132566532 dual oxidase 2 precursor [Homo sapiens] (1548 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|132566532 dual oxidase 2 precursor [Homo sapiens] 3157 0.0 gi|20149640 dual oxidase 1 precursor [Homo sapiens] 2435 0.0 gi|28872751 dual oxidase 1 precursor [Homo sapiens] 2435 0.0 gi|20127624 NADPH oxidase, EF-hand calcium binding domain 5 [Hom... 248 3e-65 gi|11136626 NADPH oxidase 3 [Homo sapiens] 235 2e-61 gi|6996021 cytochrome b-245 beta polypeptide [Homo sapiens] 227 8e-59 gi|148536873 NADPH oxidase 1 isoform long [Homo sapiens] 224 5e-58 gi|7669510 NADPH oxidase 1 isoform long variant [Homo sapiens] 191 5e-48 gi|126517478 peroxidasin homolog-like [Homo sapiens] 148 3e-35 gi|109150416 peroxidasin [Homo sapiens] 145 4e-34 gi|219842348 NADPH oxidase 4 isoform c [Homo sapiens] 144 5e-34 gi|8393843 NADPH oxidase 4 isoform a [Homo sapiens] 144 5e-34 gi|4503595 eosinophil peroxidase [Homo sapiens] 124 7e-28 gi|28558982 thyroid peroxidase isoform a [Homo sapiens] 120 1e-26 gi|28558988 thyroid peroxidase isoform d [Homo sapiens] 120 1e-26 gi|231569458 lactoperoxidase isoform 3 preproprotein [Homo sapiens] 119 2e-26 gi|40549418 lactoperoxidase isoform 1 preproprotein [Homo sapiens] 117 7e-26 gi|4557759 myeloperoxidase [Homo sapiens] 115 4e-25 gi|219842346 NADPH oxidase 4 isoform b [Homo sapiens] 87 1e-16 gi|28558984 thyroid peroxidase isoform b [Homo sapiens] 79 3e-14 gi|40254415 guanylate cyclase activator 1A (retina) [Homo sapiens] 66 3e-10 gi|28558990 thyroid peroxidase isoform e [Homo sapiens] 65 4e-10 gi|4506025 protein phosphatase 3, regulatory subunit B, alpha is... 62 3e-09 gi|13375787 EF-hand calcium binding domain 1 isoform a [Homo sap... 60 1e-08 gi|98985795 neurocalcin delta [Homo sapiens] 60 2e-08 gi|98985793 neurocalcin delta [Homo sapiens] 60 2e-08 gi|98985791 neurocalcin delta [Homo sapiens] 60 2e-08 gi|98985789 neurocalcin delta [Homo sapiens] 60 2e-08 gi|98985787 neurocalcin delta [Homo sapiens] 60 2e-08 gi|98985785 neurocalcin delta [Homo sapiens] 60 2e-08 >gi|132566532 dual oxidase 2 precursor [Homo sapiens] Length = 1548 Score = 3157 bits (8185), Expect = 0.0 Identities = 1548/1548 (100%), Positives = 1548/1548 (100%) Query: 1 MLRARPEALMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRR 60 MLRARPEALMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRR Sbjct: 1 MLRARPEALMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRR 60 Query: 61 VPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVE 120 VPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVE Sbjct: 61 VPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVE 120 Query: 121 TPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLD 180 TPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLD Sbjct: 121 TPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLD 180 Query: 181 GSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAF 240 GSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAF Sbjct: 181 GSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAF 240 Query: 241 GAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYE 300 GAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYE Sbjct: 241 GAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYE 300 Query: 301 WLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKG 360 WLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKG Sbjct: 301 WLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKG 360 Query: 361 FQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKF 420 FQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKF Sbjct: 361 FQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKF 420 Query: 421 SRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLS 480 SRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLS Sbjct: 421 SRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLS 480 Query: 481 QLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTL 540 QLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTL Sbjct: 481 QLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTL 540 Query: 541 RDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAI 600 RDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAI Sbjct: 541 RDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAI 600 Query: 601 TIIALCCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSS 660 TIIALCCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSS Sbjct: 601 TIIALCCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSS 660 Query: 661 PIIIQLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLF 720 PIIIQLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLF Sbjct: 661 PIIIQLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLF 720 Query: 721 SSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVL 780 SSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVL Sbjct: 721 SSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVL 780 Query: 781 DINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLS 840 DINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLS Sbjct: 781 DINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLS 840 Query: 841 FREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQL 900 FREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQL Sbjct: 841 FREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQL 900 Query: 901 AEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNI 960 AEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNI Sbjct: 901 AEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNI 960 Query: 961 SCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQ 1020 SCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQ Sbjct: 961 SCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQ 1020 Query: 1021 RGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGI 1080 RGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGI Sbjct: 1021 RGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGI 1080 Query: 1081 ILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAIL 1140 ILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAIL Sbjct: 1081 ILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAIL 1140 Query: 1141 HSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLA 1200 HSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLA Sbjct: 1141 HSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLA 1200 Query: 1201 IMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGD 1260 IMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGD Sbjct: 1201 IMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGD 1260 Query: 1261 KLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTL 1320 KLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTL Sbjct: 1261 KLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTL 1320 Query: 1321 TSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVS 1380 TSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVS Sbjct: 1321 TSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVS 1380 Query: 1381 VLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEEND 1440 VLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEEND Sbjct: 1381 VLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEEND 1440 Query: 1441 HQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFN 1500 HQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFN Sbjct: 1441 HQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFN 1500 Query: 1501 SLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF 1548 SLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF Sbjct: 1501 SLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF 1548 >gi|20149640 dual oxidase 1 precursor [Homo sapiens] Length = 1551 Score = 2435 bits (6310), Expect = 0.0 Identities = 1207/1551 (77%), Positives = 1331/1551 (85%), Gaps = 15/1551 (0%) Query: 9 LMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYADG 68 L L LL G+ P G Q+ +S WEVQR+DGW+NNL H G+ G RLQR VPA+YADG Sbjct: 5 LALAWTLLVGAWTPLGAQNPIS--WEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADG 62 Query: 69 VYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVETPGCPAEF 128 VYQ L EP LPNPR LSN +RG AGL SL NRTVLGVFFGYHVLSD+VSVETPGCPAEF Sbjct: 63 VYQPLGEPHLPNPRDLSNTISRGPAGLASLRNRTVLGVFFGYHVLSDLVSVETPGCPAEF 122 Query: 129 LNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSS 188 LNIRIPPGDP+FDPDQRGDVVLPFQRSRWDPETGRSPSNPRD ANQVTGWLDGSAIYGSS Sbjct: 123 LNIRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDPANQVTGWLDGSAIYGSS 182 Query: 189 HSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNRE 248 HSWSDALRSFS GQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNRE Sbjct: 183 HSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNRE 242 Query: 249 PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQK 308 PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQK Sbjct: 243 PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQK 302 Query: 309 TLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSSQALR 368 TLPEYTGYRPFLDPSIS EFV ASEQF STMVPPGVYMRNASCHF+ V+N+ S+ALR Sbjct: 303 TLPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSVSRALR 362 Query: 369 VCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKFSRTDYVAS 428 VCN+YW RE+P+L S ++V+ LLLGMASQI+E ED+++VED+RD+WPGP KFSRTD++AS Sbjct: 363 VCNSYWSREHPSLQSAEDVDALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSRTDHLAS 422 Query: 429 SIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNV---DPQVLEATAALYNQDLSQLELL 485 +QRGRD+GLPSY++A A GL W D+NP + + VLEATAALYNQDLS LELL Sbjct: 423 CLQRGRDLGLPSYTKARAALGLSPITRWQDINPALSRSNDTVLEATAALYNQDLSWLELL 482 Query: 486 LGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTLRDVLV 545 GGLLESH DPGPLFS IVL+QFVRLRDGDRYWFENTRNGLFSKKEIE+IRNTTL+DVLV Sbjct: 483 PGGLLESHRDPGPLFSTIVLEQFVRLRDGDRYWFENTRNGLFSKKEIEEIRNTTLQDVLV 542 Query: 546 AVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAITIIAL 605 AVINIDPSALQPNVFVWHKG PCPQP+QL+T+GLP CAP V D+FEGS GF +TI L Sbjct: 543 AVINIDPSALQPNVFVWHKGDPCPQPRQLSTEGLPACAPSVVRDYFEGSGFGFGVTIGTL 602 Query: 606 CCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSSPIIIQ 665 CC PLVSLL + +VA R R K+LQ + ++S+ E G+ A+EW G KE P+++ Sbjct: 603 CCFPLVSLLSAWIVARLRMRNFKRLQGQDRQSIVSEKLVGGMEALEWQGHKEPCRPVLVY 662 Query: 666 LLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLFSSEEE 725 L + ++V++ LTVLR +QLQP Q+VN +LS+NRG RTLLLKIPKEYDLVLLF+ EEE Sbjct: 663 LQPGQ-IRVVDGRLTVLRTIQLQPPQKVNFVLSSNRGRRTLLLKIPKEYDLVLLFNLEEE 721 Query: 726 RGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVLDINQA 785 R A V+ L L + E+ E+EL R AVT++QR +LE FFRHLF+QVLDINQA Sbjct: 722 RQALVENLRGALKESGLSIQEWELREQELMRAAVTREQRRHLLETFFRHLFSQVLDINQA 781 Query: 786 DAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFL 845 DAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFL Sbjct: 782 DAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFL 841 Query: 846 DILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVE 905 DILVVFMKGSPE+KSRLMF MYD D NG +SKDEF M+RSFIEISNNCLSKAQLAEVVE Sbjct: 842 DILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVE 901 Query: 906 SMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFK------QN 959 SMFRESGFQDKEELTWEDFHFMLRDH+SELRFTQLCVKG I+D+ + Q+ Sbjct: 902 SMFRESGFQDKEELTWEDFHFMLRDHNSELRFTQLCVKGVEVP-EVIKDLCRRASYISQD 960 Query: 960 ISCRVSFITRTPGERSHPQGLGPPAPEAPELGGPG--LKKRFGKKAAVPTPRLYTEALQE 1017 + C ++ L P + P P +++RFGKK P L+TEA +E Sbjct: 961 MICPSPRVSARCSRSDIETELTPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHRE 1020 Query: 1018 KMQRGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTL 1077 K QR L Q +QQ+KRF+ENYRRHI CVA+F AI G+F +RAYYY FA+ + I TT Sbjct: 1021 KFQRSCLHQTVQQFKRFIENYRRHIGCVAVFYAIAGGLFLERAYYYAFAAHHTGITDTTR 1080 Query: 1078 VGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVL 1137 VGIILSRGTAAS+SFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHR IA A+VL Sbjct: 1081 VGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRLIASTAIVL 1140 Query: 1138 AILHSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLL 1197 +LHS GH VNVY+FS+SPLS+L+C+FP +F +DGS+LPQK+YWWFFQTVPG+TGV+LLL Sbjct: 1141 TVLHSVGHVVNVYLFSISPLSVLSCLFPGLFHDDGSELPQKYYWWFFQTVPGLTGVVLLL 1200 Query: 1198 VLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIY 1257 +LAIMYVFASHHFRRRSFRGFWLTHHLYILLY LLIIHGS+ALIQLP FHI+FLVPAIIY Sbjct: 1201 ILAIMYVFASHHFRRRSFRGFWLTHHLYILLYVLLIIHGSFALIQLPRFHIFFLVPAIIY 1260 Query: 1258 GGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHP 1317 GGDKLVSLSRKKVEISVVKAELLPSGVT+L+FQRPQGFEYKSGQWVRIACLALGTTEYHP Sbjct: 1261 GGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHP 1320 Query: 1318 FTLTSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKF 1377 FTLTSAPHEDTLSLHIRA GPWTTRLREIYS+P G+ CA YPKLYLDGPFGEGHQEWHKF Sbjct: 1321 FTLTSAPHEDTLSLHIRAAGPWTTRLREIYSAPTGDRCARYPKLYLDGPFGEGHQEWHKF 1380 Query: 1378 EVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVE 1437 EVSVLVGGGIGVTPFASILKDLVFKSS+ Q+ CKKIYFIWVTRTQRQFEWLADII+EVE Sbjct: 1381 EVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVE 1440 Query: 1438 ENDHQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEP 1497 ENDHQDLVSVHIY+TQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEP Sbjct: 1441 ENDHQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEP 1500 Query: 1498 FFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF 1548 FFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQL+NRQDR HF HHYENF Sbjct: 1501 FFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF 1551 >gi|28872751 dual oxidase 1 precursor [Homo sapiens] Length = 1551 Score = 2435 bits (6310), Expect = 0.0 Identities = 1207/1551 (77%), Positives = 1331/1551 (85%), Gaps = 15/1551 (0%) Query: 9 LMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYADG 68 L L LL G+ P G Q+ +S WEVQR+DGW+NNL H G+ G RLQR VPA+YADG Sbjct: 5 LALAWTLLVGAWTPLGAQNPIS--WEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADG 62 Query: 69 VYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVETPGCPAEF 128 VYQ L EP LPNPR LSN +RG AGL SL NRTVLGVFFGYHVLSD+VSVETPGCPAEF Sbjct: 63 VYQPLGEPHLPNPRDLSNTISRGPAGLASLRNRTVLGVFFGYHVLSDLVSVETPGCPAEF 122 Query: 129 LNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSS 188 LNIRIPPGDP+FDPDQRGDVVLPFQRSRWDPETGRSPSNPRD ANQVTGWLDGSAIYGSS Sbjct: 123 LNIRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDPANQVTGWLDGSAIYGSS 182 Query: 189 HSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNRE 248 HSWSDALRSFS GQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNRE Sbjct: 183 HSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNRE 242 Query: 249 PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQK 308 PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQK Sbjct: 243 PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQK 302 Query: 309 TLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSSQALR 368 TLPEYTGYRPFLDPSIS EFV ASEQF STMVPPGVYMRNASCHF+ V+N+ S+ALR Sbjct: 303 TLPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSVSRALR 362 Query: 369 VCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKFSRTDYVAS 428 VCN+YW RE+P+L S ++V+ LLLGMASQI+E ED+++VED+RD+WPGP KFSRTD++AS Sbjct: 363 VCNSYWSREHPSLQSAEDVDALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSRTDHLAS 422 Query: 429 SIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNV---DPQVLEATAALYNQDLSQLELL 485 +QRGRD+GLPSY++A A GL W D+NP + + VLEATAALYNQDLS LELL Sbjct: 423 CLQRGRDLGLPSYTKARAALGLSPITRWQDINPALSRSNDTVLEATAALYNQDLSWLELL 482 Query: 486 LGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTLRDVLV 545 GGLLESH DPGPLFS IVL+QFVRLRDGDRYWFENTRNGLFSKKEIE+IRNTTL+DVLV Sbjct: 483 PGGLLESHRDPGPLFSTIVLEQFVRLRDGDRYWFENTRNGLFSKKEIEEIRNTTLQDVLV 542 Query: 546 AVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAITIIAL 605 AVINIDPSALQPNVFVWHKG PCPQP+QL+T+GLP CAP V D+FEGS GF +TI L Sbjct: 543 AVINIDPSALQPNVFVWHKGDPCPQPRQLSTEGLPACAPSVVRDYFEGSGFGFGVTIGTL 602 Query: 606 CCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSSPIIIQ 665 CC PLVSLL + +VA R R K+LQ + ++S+ E G+ A+EW G KE P+++ Sbjct: 603 CCFPLVSLLSAWIVARLRMRNFKRLQGQDRQSIVSEKLVGGMEALEWQGHKEPCRPVLVY 662 Query: 666 LLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLFSSEEE 725 L + ++V++ LTVLR +QLQP Q+VN +LS+NRG RTLLLKIPKEYDLVLLF+ EEE Sbjct: 663 LQPGQ-IRVVDGRLTVLRTIQLQPPQKVNFVLSSNRGRRTLLLKIPKEYDLVLLFNLEEE 721 Query: 726 RGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVLDINQA 785 R A V+ L L + E+ E+EL R AVT++QR +LE FFRHLF+QVLDINQA Sbjct: 722 RQALVENLRGALKESGLSIQEWELREQELMRAAVTREQRRHLLETFFRHLFSQVLDINQA 781 Query: 786 DAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFL 845 DAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFL Sbjct: 782 DAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFL 841 Query: 846 DILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVE 905 DILVVFMKGSPE+KSRLMF MYD D NG +SKDEF M+RSFIEISNNCLSKAQLAEVVE Sbjct: 842 DILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVE 901 Query: 906 SMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFK------QN 959 SMFRESGFQDKEELTWEDFHFMLRDH+SELRFTQLCVKG I+D+ + Q+ Sbjct: 902 SMFRESGFQDKEELTWEDFHFMLRDHNSELRFTQLCVKGVEVP-EVIKDLCRRASYISQD 960 Query: 960 ISCRVSFITRTPGERSHPQGLGPPAPEAPELGGPG--LKKRFGKKAAVPTPRLYTEALQE 1017 + C ++ L P + P P +++RFGKK P L+TEA +E Sbjct: 961 MICPSPRVSARCSRSDIETELTPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHRE 1020 Query: 1018 KMQRGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTL 1077 K QR L Q +QQ+KRF+ENYRRHI CVA+F AI G+F +RAYYY FA+ + I TT Sbjct: 1021 KFQRSCLHQTVQQFKRFIENYRRHIGCVAVFYAIAGGLFLERAYYYAFAAHHTGITDTTR 1080 Query: 1078 VGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVL 1137 VGIILSRGTAAS+SFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHR IA A+VL Sbjct: 1081 VGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRLIASTAIVL 1140 Query: 1138 AILHSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLL 1197 +LHS GH VNVY+FS+SPLS+L+C+FP +F +DGS+LPQK+YWWFFQTVPG+TGV+LLL Sbjct: 1141 TVLHSVGHVVNVYLFSISPLSVLSCLFPGLFHDDGSELPQKYYWWFFQTVPGLTGVVLLL 1200 Query: 1198 VLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIY 1257 +LAIMYVFASHHFRRRSFRGFWLTHHLYILLY LLIIHGS+ALIQLP FHI+FLVPAIIY Sbjct: 1201 ILAIMYVFASHHFRRRSFRGFWLTHHLYILLYVLLIIHGSFALIQLPRFHIFFLVPAIIY 1260 Query: 1258 GGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHP 1317 GGDKLVSLSRKKVEISVVKAELLPSGVT+L+FQRPQGFEYKSGQWVRIACLALGTTEYHP Sbjct: 1261 GGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHP 1320 Query: 1318 FTLTSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKF 1377 FTLTSAPHEDTLSLHIRA GPWTTRLREIYS+P G+ CA YPKLYLDGPFGEGHQEWHKF Sbjct: 1321 FTLTSAPHEDTLSLHIRAAGPWTTRLREIYSAPTGDRCARYPKLYLDGPFGEGHQEWHKF 1380 Query: 1378 EVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVE 1437 EVSVLVGGGIGVTPFASILKDLVFKSS+ Q+ CKKIYFIWVTRTQRQFEWLADII+EVE Sbjct: 1381 EVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVE 1440 Query: 1438 ENDHQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEP 1497 ENDHQDLVSVHIY+TQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEP Sbjct: 1441 ENDHQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEP 1500 Query: 1498 FFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF 1548 FFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQL+NRQDR HF HHYENF Sbjct: 1501 FFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF 1551 >gi|20127624 NADPH oxidase, EF-hand calcium binding domain 5 [Homo sapiens] Length = 747 Score = 248 bits (633), Expect = 3e-65 Identities = 213/807 (26%), Positives = 352/807 (43%), Gaps = 176/807 (21%) Query: 805 ELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEDKSRLMF 864 E+S EF +L +K + F E F+L D D +G ++ +E + L + + GSP DK + +F Sbjct: 26 EISLQEFKAALHVK-ESFFAERFFALFDSDRSGTITLQELQEALTLLIHGSPMDKLKFLF 84 Query: 865 TMYDLD---ENGFLSKDEFFT-----MMRSFIEISNNCLSKAQLAEVVESMFRESGF--- 913 +YD+D G + E+ S + + + +L V++S RES Sbjct: 85 QVYDIDVCARQGASAGTEWGAGAGPHWASSPLGTGSGSIDPDELRTVLQSCLRESAISLP 144 Query: 914 -QDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNISCRVSFITRTPG 972 + ++LT F D + + F +L RD + R PG Sbjct: 145 DEKLDQLTLALFESADADGNGAITFEEL------------RDELQ-----------RFPG 181 Query: 973 ER-----SHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQRGFLAQK 1027 S L PAP P PR + Sbjct: 182 VMENLTISAAHWLTAPAPR-------------------PRPR----------------RP 206 Query: 1028 LQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTA 1087 Q + + N+R + C+A ++ + V +F A S D+ + +V ++G Sbjct: 207 RQLTRAYWHNHRSQLFCLATYAGLHVLLFGLAA------SAHRDLGASVMV----AKGCG 256 Query: 1088 ASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAILHSAGHAV 1147 ++F S+I + M R +T+LR T+L + +P D + FH+ + V L+++H+ H V Sbjct: 257 QCLNFDCSFIAVLMLRRCLTWLRATWLAQVLPLDQNIQFHQLMGYVVVGLSLVHTVAHTV 316 Query: 1148 NVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGM---------TGVLLLLV 1198 N + + + S P +F+ T PG+ TGV LLL+ Sbjct: 317 NFVLQAQAEAS-----------------PFQFWELLLTTRPGIGWVHGSASPTGVALLLL 359 Query: 1199 LAIMYVFASHHFRRRS-FRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIY 1257 L +M++ +S RR F F+ TH Y+L++ LLI HG P F + LVP I++ Sbjct: 360 LLLMFICSSSCIRRSGHFEVFYWTHLSYLLVWLLLIFHG-------PNFWKWLLVPGILF 412 Query: 1258 GGDKLVSLS-RKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYH 1316 +K + L+ + + +++ LLPS VT+L +RP F Y+ G ++ + + E+H Sbjct: 413 FLEKAIGLAVSRMAAVCIMEVNLLPSKVTHLLIKRPPFFHYRPGDYLYLNIPTIARYEWH 472 Query: 1317 PFTLTSAPHE-DTLSLHIRAVGPWTTRLREIY--SSPKGNGCAGYP-------------- 1359 PFT++SAP + DT+ LHIR+ G WT RL E + S P G G Sbjct: 473 PFTISSAPEQKDTIWLHIRSQGQWTNRLYESFKASDPLGRGSKRLSRSVTMRKSQRSSKG 532 Query: 1360 -------------KLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFK---- 1402 K Y+DGP+G + E +VL+G GIG+TPFASIL+ ++++ Sbjct: 533 SEILLEKHKFCNIKCYIDGPYGTPTRRIFASEHAVLIGAGIGITPFASILQSIMYRHQKR 592 Query: 1403 ------------SSLGSQMLCKKIYFIWVTRTQRQFEWLADII-----QEVEENDHQDLV 1445 + M K+ FIW+ R QR FEW ++ + EE + + Sbjct: 593 KHTCPSCQHSWIEGVQDNMKLHKVDFIWINRDQRSFEWFVSLLTKLEMDQAEEAQYGRFL 652 Query: 1446 SVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEV 1505 +H+Y+T K D++ L + + TGL++ T GRP + F Q+V Sbjct: 653 ELHMYMTSALGKNDMKAIGLQMALDLLANKEKKDSITGLQTRTQPGRPDWSKVF---QKV 709 Query: 1506 HPQVR-KIGVFSCGPPGMTKNVEKACQ 1531 + + K+ VF CG P + K ++ C+ Sbjct: 710 AAEKKGKVQVFFCGSPALAKVLKGHCE 736 >gi|11136626 NADPH oxidase 3 [Homo sapiens] Length = 568 Score = 235 bits (600), Expect = 2e-61 Identities = 157/526 (29%), Positives = 256/526 (48%), Gaps = 71/526 (13%) Query: 1083 SRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVD----FHRWIAMAAVVLA 1138 +R +A ++F IL+ + RNLI+F+R T + P+ +D FH+ +A V A Sbjct: 54 ARASALCLNFNCMLILIPVSRNLISFIRGTSICCRGPWRRQLDKNLRFHKLVAYGIAVNA 113 Query: 1139 ILHSAGHAVNVYIF----SVSPLSLLACIF-----PNV-FVNDGSKLPQKFYWWFFQTVP 1188 +H H N+ + S LLA + PN ++N P +T+ Sbjct: 114 TIHIVAHFFNLERYHWSQSEEAQGLLAALSKLGNTPNESYLNPVRTFPTNTTTELLRTIA 173 Query: 1189 GMTGVLLLLVLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQ------ 1242 G+TG+++ L L ++ ++ R+ S+ FW THH++I+ + L IHG+ +++ Sbjct: 174 GVTGLVISLALVLIMTSSTEFIRQASYELFWYTHHVFIVFFLSLAIHGTGRIVRGQTQDS 233 Query: 1243 ------------------------------LPTFHIYFLVPAIIYGGDKLVSLSRKKVEI 1272 P+ + L P ++Y ++++ R + E+ Sbjct: 234 LSLHNITFCRDRYAEWQTVAQCPVPQFSGKEPSAWKWILGPVVLYACERIIRFWRFQQEV 293 Query: 1273 SVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLH 1332 + K PSGV L ++ +GF+ GQ++ + C A+ + E+HPFTLTSAP ED S+H Sbjct: 294 VITKVVSHPSGVLELHMKK-RGFKMAPGQYILVQCPAISSLEWHPFTLTSAPQEDFFSVH 352 Query: 1333 IRAVGPWTTRLREIYSSPKGNGCA---GYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGV 1389 IRA G WT L E + + +G P+L +DGPFG + + V V V GIGV Sbjct: 353 IRAAGDWTAALLEAFGA-EGQALQEPWSLPRLAVDGPFGTALTDVFHYPVCVCVAAGIGV 411 Query: 1390 TPFASILKDLVFK-SSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVE----ENDHQDL 1444 TPFA++LK + +K S + + K+YF W+ R R FEW AD++ +E E Sbjct: 412 TPFAALLKSIWYKCSEAQTPLKLSKVYFYWICRDARAFEWFADLLLSLETRMSEQGKTHF 471 Query: 1445 VSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQE 1504 +S HI++T E L + H+ + N + TGL+ T +GRP + F + Sbjct: 472 LSYHIFLTGWDENQALHIAL------HWDE--NTDVITGLKQKTFYGRPNWNNEFKQIAY 523 Query: 1505 VHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQD--RAHFMHHYENF 1548 HP IGVF CGP +++ ++K C L + D HF ++ E+F Sbjct: 524 NHPS-SSIGVFFCGPKALSRTLQKMCHLYSSADPRGVHFYYNKESF 568 >gi|6996021 cytochrome b-245 beta polypeptide [Homo sapiens] Length = 570 Score = 227 bits (578), Expect = 8e-59 Identities = 166/564 (29%), Positives = 269/564 (47%), Gaps = 82/564 (14%) Query: 1053 VGVFADRAYYYGFASPPSDIAQTTLVG--IILSRGTAASVSFMFSYILLTMCRNLITFLR 1110 + VF YY + PP L+G + L+R AA ++F ILL +CRNL++FLR Sbjct: 21 LNVFLFVWYYRVYDIPPKFFYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLR 80 Query: 1111 ------ETFLNRYVPFDAAVDFHRWIAMAAVVLAILHSAGHAVNV-------------YI 1151 T + R + D + FH+ +A + + +H+ H NV Y Sbjct: 81 GSSACCSTRVRRQL--DRNLTFHKMVAWMIALHSAIHTIAHLFNVEWCVNARVNNSDPYS 138 Query: 1152 FSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLAIMYVFASHHFR 1211 ++S L F K P+ + + G+TGV++ L L ++ ++ R Sbjct: 139 VALSELGDRQNESYLNFARKRIKNPEGGLYLAVTLLAGITGVVITLCLILIITSSTKTIR 198 Query: 1212 RRSFRGFWLTHHLYILLYALLIIHGSYALIQ----------------------------- 1242 R F FW THHL+++ + L IHG+ +++ Sbjct: 199 RSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLAVHNITVCEQKISEWGKIKECP 258 Query: 1243 LPTFH-------IYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGF 1295 +P F + + P +Y ++LV R + ++ + K P LQ ++ +GF Sbjct: 259 IPQFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKK-KGF 317 Query: 1296 EYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGC 1355 + + GQ++ + C + E+HPFTLTSAP ED S+HIR VG WT L K Sbjct: 318 KMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGDWTEGLFNACGCDKQEFQ 377 Query: 1356 AGY--PKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFK-SSLGSQMLCK 1412 + PK+ +DGPFG ++ +EV +LVG GIGVTPFASILK + +K + + + K Sbjct: 378 DAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCNNATNLKLK 437 Query: 1413 KIYFIWVTRTQRQFEWLADIIQ----EVEENDHQDLVSVHIYVTQLAEKFDLRTTMLYIC 1468 KIYF W+ R FEW AD++Q +++E ++ +S +IY+T E + + Sbjct: 438 KIYFYWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYLTGWDE-----SQANHFA 492 Query: 1469 ERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEK 1528 H ++ + + TGL+ T +GRP ++ F ++ HP R IGVF CGP + + + K Sbjct: 493 VHHDEE---KDVITGLKQKTLYGRPNWDNEFKTIASQHPNTR-IGVFLCGPEALAETLSK 548 Query: 1529 ACQLVNRQDR----AHFMHHYENF 1548 Q ++ + HF+ + ENF Sbjct: 549 --QSISNSESGPRGVHFIFNKENF 570 >gi|148536873 NADPH oxidase 1 isoform long [Homo sapiens] Length = 564 Score = 224 bits (571), Expect = 5e-58 Identities = 165/575 (28%), Positives = 272/575 (47%), Gaps = 74/575 (12%) Query: 1034 FVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTAASVSFM 1093 +V N+ ++ + ++ + V +F D Y A + + +R +A ++F Sbjct: 4 WVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCLNFN 63 Query: 1094 FSYILLTMCRNLITFLRET--FLNRYV--PFDAAVDFHRWIAMAAVVLAILHSAGHAVNV 1149 + ILL +CRNL++FLR T F +R + D + FH+ +A + +H H N Sbjct: 64 STLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHLFNF 123 Query: 1150 YIFSVSPLSL---LACIFPNV---------FVNDGSKLPQKFYWWFFQTVPGMTGVLLLL 1197 +S S + LA I ++ ++N + F ++ G+TGV++ + Sbjct: 124 DCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVIMTI 183 Query: 1198 VLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPT------------ 1245 L +M A+ RR F FW THHL+I L IHG +++ T Sbjct: 184 ALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHPRKC 243 Query: 1246 ---FHIY----------------------FLVPAIIYGGDKLVSLSRKKVEISVVKAELL 1280 F ++ L P I+Y ++++ R + ++ + K + Sbjct: 244 AESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKVVMH 303 Query: 1281 PSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAVGPWT 1340 PS V LQ + +GF + GQ++ + C ++ E+HPFTLTSAP ED S+HIRA G WT Sbjct: 304 PSKVLELQMNK-RGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGDWT 362 Query: 1341 TRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLV 1400 L + + P++ +DGPFG ++ ++EV+VLVG GIGVTPFASILK + Sbjct: 363 ENLIRAFEQQ----YSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIW 418 Query: 1401 FKSSLGSQML-CKKIYFIWVTRTQRQFEW----LADIIQEVEENDHQDLVSVHIYVTQLA 1455 +K L KKIYF W+ R F W L + QE+EE ++ +++T Sbjct: 419 YKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLT--- 475 Query: 1456 EKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVF 1515 + ++ +F K + + TGL+ T FGRP ++ F+++ HP+ +GVF Sbjct: 476 ---GWDSNIVGHAALNFDKATD--IVTGLKQKTSFGRPMWDNEFSTIATSHPK-SVVGVF 529 Query: 1516 SCGPPGMTKNVEKACQLVNRQD--RAHFMHHYENF 1548 CGP + K++ K C + D + F + ENF Sbjct: 530 LCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF 564 >gi|7669510 NADPH oxidase 1 isoform long variant [Homo sapiens] Length = 515 Score = 191 bits (485), Expect = 5e-48 Identities = 154/570 (27%), Positives = 248/570 (43%), Gaps = 113/570 (19%) Query: 1034 FVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTAASVSFM 1093 +V N+ ++ + ++ + V +F D Y A + + +R +A ++F Sbjct: 4 WVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCLNFN 63 Query: 1094 FSYILLTMCRNLITFLRET--FLNRYV--PFDAAVDFHRWIAMAAVVLAILHSAGHAVNV 1149 + ILL +CRNL++FLR T F +R + D + FH+ +A + +H H N Sbjct: 64 STLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHLFNF 123 Query: 1150 YIFSVSPLSL---LACIFPNV---------FVNDGSKLPQKFYWWFFQTVPGMTGVLLLL 1197 +S S + LA I ++ ++N + F ++ G+TGV++ + Sbjct: 124 DCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVIMTI 183 Query: 1198 VLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPT------------ 1245 L +M A+ RR F FW THHL+I L IHG +++ T Sbjct: 184 ALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHPRKC 243 Query: 1246 ---FHIY----------------------FLVPAIIYGGDKLVSLSRKKVEISVVKAELL 1280 F ++ L P I+Y ++++ R + ++ + K + Sbjct: 244 AESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKVVMH 303 Query: 1281 PSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAVGPWT 1340 PS V LQ + +GF + GQ++ + C ++ E+HPFTLTSAP ED S+HIRA G WT Sbjct: 304 PSKVLELQMNK-RGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGDWT 362 Query: 1341 TRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLV 1400 L + + P++ +DGPFG ++ ++EV+VLVG GIGVTPFASILK + Sbjct: 363 ENLIRAFEQQ----YSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIW 418 Query: 1401 FKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEENDHQDLVSVHIYVTQLAEKFDL 1460 +K L K V A FD Sbjct: 419 YKFQCADHNLKTK------------------------------------KVGHAALNFDK 442 Query: 1461 RTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPP 1520 T + TGL+ T FGRP ++ F+++ HP+ +GVF CGP Sbjct: 443 AT----------------DIVTGLKQKTSFGRPMWDNEFSTIATSHPK-SVVGVFLCGPR 485 Query: 1521 GMTKNVEKACQLVNRQD--RAHFMHHYENF 1548 + K++ K C + D + F + ENF Sbjct: 486 TLAKSLRKCCHRYSSLDPRKVQFYFNKENF 515 >gi|126517478 peroxidasin homolog-like [Homo sapiens] Length = 1463 Score = 148 bits (374), Expect = 3e-35 Identities = 155/543 (28%), Positives = 232/543 (42%), Gaps = 51/543 (9%) Query: 38 YDGWFNNLRHHERGAVGCRLQRRVPANYADGVY--QALEEP-----QLPNPRRLSNAATR 90 +DG NNL+ GA R + Y DG+ + L P LP PR ++ R Sbjct: 730 HDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPPRLVATVWAR 789 Query: 91 GIAGLPSLHNRTVLGVFFGYHVLSD----VVSVETP----GCPAEFLNIRIPPGDPV--- 139 A P H+ T + + +G+ + D V ++ T G P + PP P+ Sbjct: 790 AAAVTPD-HSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFPMNTR 848 Query: 140 -FDPDQRGDVVLPFQRSRWDPETGRSPSN-----PRDLANQVTGWLDGSAIYGSSHSWSD 193 DP + F RS +GR + R+ NQ T ++DGS +YGSS S Sbjct: 849 HADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVYGSSERESQ 908 Query: 194 ALR--SFSGGQLASGPDPAFP-RDSQNPLLMWAA--PDPATGQNGPRGLYAFGAERGNRE 248 ALR S G L +G FP S PLL ++ P Q + G R N Sbjct: 909 ALRDPSVPRGLLKTG----FPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHRANEH 964 Query: 249 PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL-- 306 L A+ LWFR HN A L+ +P WE ++Q ARK V A Q+I WLP L Sbjct: 965 LALAAMHTLWFREHNRVATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKVLGD 1024 Query: 307 --QKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSS 364 + L Y GY P ++ I F A+ +F T++ P +Y NA+ +++G Sbjct: 1025 PGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATL---GEISEGHLPF 1081 Query: 365 QALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKFSRTD 424 + I+E V L G+A++ ++ +L + D Sbjct: 1082 HKALFSPSRIIKE----GGIDPVLRGLFGVAAK-WRAPSYLLSPELTQRLFSAAYSAAVD 1136 Query: 425 YVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNV-DPQVLEATAALYNQ--DLSQ 481 A+ IQRGRD G+P Y + L +N+ DL + D ++ + LY D+ Sbjct: 1137 SAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDL 1196 Query: 482 LELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTLR 541 L+ L GP + + QF RLRDGDR+W+EN G+F+ ++ ++ +L Sbjct: 1197 WPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENP--GVFTPAQLTQLKQASLS 1254 Query: 542 DVL 544 VL Sbjct: 1255 RVL 1257 >gi|109150416 peroxidasin [Homo sapiens] Length = 1479 Score = 145 bits (365), Expect = 4e-34 Identities = 153/568 (26%), Positives = 241/568 (42%), Gaps = 98/568 (17%) Query: 38 YDGWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPS 97 +DG NNL+H GA +R + + Y +G P+ NP RL N +P Sbjct: 744 HDGTCNNLQHPMWGASLTAFERLLKSVYENG----FNTPRGINPHRLYNGHA---LPMPR 796 Query: 98 LHNRTVLGV------------------FFGYHVLSDVVSVET----------------PG 123 L + T++G F + + S VV++ P Sbjct: 797 LVSTTLIGTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCSNDPP 856 Query: 124 CPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSN-------PRDLANQVT 176 C ++ IPP D + G + F RS P G ++ PR+ NQ+T Sbjct: 857 C----FSVMIPPND---SRARSGARCMFFVRS--SPVCGSGMTSLLMNSVYPREQINQLT 907 Query: 177 GWLDGSAIYGSSHSWSDALRSFSG--GQLASGPDPAFPRDSQNPLLMWAAPDPAT----G 230 ++D S +YGS+ + ++R + G L G + S PLL +A P Sbjct: 908 SYIDASNVYGSTEHEARSIRDLASHRGLLRQG----IVQRSGKPLLPFATGPPTECMRDE 963 Query: 231 QNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVI 290 P + G R N + L ++ LWFR HN A L + +P W+ + ++ RK V Sbjct: 964 NESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVG 1023 Query: 291 ATYQNIAVYEWLPSFL----QKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYM 346 A Q+I WLP L +TL EY GY P ++ I F A+ +F T+V P +Y Sbjct: 1024 AEIQHITYQHWLPKILGEVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPLLYR 1083 Query: 347 RNASCHFRKV------LNKGFQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISE 400 + +F+ + L+K F S R+ N I +P L L G+A ++ Sbjct: 1084 LDE--NFQPIAQDHLPLHKAFFS--PFRIVNEGGI--DPLLRG-------LFGVAGKM-R 1129 Query: 401 LEDNIVVEDLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLN 460 + ++ +L + D A +IQRGRD G+P Y + L + DL Sbjct: 1130 VPSQLLNTELTERLFSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLK 1189 Query: 461 PNV-DPQVLEATAALYNQDLSQLELLLGGLLES---HGDPGPLFSAIVLDQFVRLRDGDR 516 + +P++ E LY L+ ++L ++E GP ++ QF RLRDGDR Sbjct: 1190 NEIKNPEIREKLKRLYGSTLN-IDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDR 1248 Query: 517 YWFENTRNGLFSKKEIEDIRNTTLRDVL 544 W+EN G+FS ++ I+ T+L +L Sbjct: 1249 LWYENP--GVFSPAQLTQIKQTSLARIL 1274 >gi|219842348 NADPH oxidase 4 isoform c [Homo sapiens] Length = 554 Score = 144 bits (364), Expect = 5e-34 Identities = 92/319 (28%), Positives = 154/319 (48%), Gaps = 36/319 (11%) Query: 1244 PTFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWV 1303 P ++ P +Y ++L R ++++ PS V ++ + + F+ + GQ++ Sbjct: 257 PQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVISHPSDVMEIRMVK-ENFKARPGQYI 315 Query: 1304 RIACLALGTTEYHPFTLTSAPHED--TLSLHIRAVGPWTTRLREIYSSPKGNGCA----- 1356 + C ++ E HPFTLT P E T +H++ VG WT R R++ P Sbjct: 316 TLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFI 375 Query: 1357 ---GYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKK 1413 YPKLY+DGPFG +E +EVS+ V GGIGVTPFASIL L+ ++ Sbjct: 376 QSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLL---DDWKPYKLRR 432 Query: 1414 IYFIWVTRTQRQFEWLADII----QEVEENDHQDLVSVHIYVTQLAEKFDLRTTMLYICE 1469 +YFIWV R + F W AD++ + + + D V++ +Y++Q Sbjct: 433 LYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQ---------------T 477 Query: 1470 RHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKA 1529 QK++ + L S GRP ++ F+ + + + + + +GVF CGP ++K + K Sbjct: 478 DGIQKIIGEK-YHALNSRLFIGRPRWKLLFDEIAK-YNRGKTVGVFCCGPNSLSKTLHKL 535 Query: 1530 CQLVNRQDRAHFMHHYENF 1548 N F ++ E+F Sbjct: 536 SN-QNNSYGTRFEYNKESF 553 Score = 79.0 bits (193), Expect = 3e-14 Identities = 54/175 (30%), Positives = 91/175 (52%), Gaps = 16/175 (9%) Query: 1078 VGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVP-------FDAAVDFHRWI 1130 +G+ LSR +A+ ++ S ILL MCR L+ +LR + + VP D + FH Sbjct: 28 LGLCLSRASASVLNLNCSLILLPMCRTLLAYLRGS---QKVPSRRTRRLLDKSRTFHITC 84 Query: 1131 AMAAVVLAILHSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGM 1190 + + + +H A H VN FSV+ + + ++ P+K F TVPG+ Sbjct: 85 GVTICIFSGVHVAAHLVNALNFSVNYSEDFVELNAARYRDED---PRKL---LFTTVPGL 138 Query: 1191 TGVLLLLVLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPT 1245 TGV +++VL +M +++ R ++ FW TH+L+ + Y LL +H S L++ T Sbjct: 139 TGVCMVVVLFLMITASTYAIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQT 193 >gi|8393843 NADPH oxidase 4 isoform a [Homo sapiens] Length = 578 Score = 144 bits (364), Expect = 5e-34 Identities = 92/319 (28%), Positives = 154/319 (48%), Gaps = 36/319 (11%) Query: 1244 PTFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWV 1303 P ++ P +Y ++L R ++++ PS V ++ + + F+ + GQ++ Sbjct: 281 PQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVISHPSDVMEIRMVK-ENFKARPGQYI 339 Query: 1304 RIACLALGTTEYHPFTLTSAPHED--TLSLHIRAVGPWTTRLREIYSSPKGNGCA----- 1356 + C ++ E HPFTLT P E T +H++ VG WT R R++ P Sbjct: 340 TLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFI 399 Query: 1357 ---GYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKK 1413 YPKLY+DGPFG +E +EVS+ V GGIGVTPFASIL L+ ++ Sbjct: 400 QSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLL---DDWKPYKLRR 456 Query: 1414 IYFIWVTRTQRQFEWLADII----QEVEENDHQDLVSVHIYVTQLAEKFDLRTTMLYICE 1469 +YFIWV R + F W AD++ + + + D V++ +Y++Q Sbjct: 457 LYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQ---------------T 501 Query: 1470 RHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKA 1529 QK++ + L S GRP ++ F+ + + + + + +GVF CGP ++K + K Sbjct: 502 DGIQKIIGEK-YHALNSRLFIGRPRWKLLFDEIAK-YNRGKTVGVFCCGPNSLSKTLHKL 559 Query: 1530 CQLVNRQDRAHFMHHYENF 1548 N F ++ E+F Sbjct: 560 SN-QNNSYGTRFEYNKESF 577 Score = 80.1 bits (196), Expect = 2e-14 Identities = 60/210 (28%), Positives = 104/210 (49%), Gaps = 16/210 (7%) Query: 1043 VCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTAASVSFMFSYILLTMC 1102 +C+ I+ ++ V +F Y + Q +G+ LSR +A+ ++ S ILL MC Sbjct: 17 LCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMC 76 Query: 1103 RNLITFLRETFLNRYVP-------FDAAVDFHRWIAMAAVVLAILHSAGHAVNVYIFSVS 1155 R L+ +LR + + VP D + FH + + + +H A H VN FSV+ Sbjct: 77 RTLLAYLRGS---QKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHVAAHLVNALNFSVN 133 Query: 1156 PLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLAIMYVFASHHFRRRSF 1215 + + ++ P+K F TVPG+TGV +++VL +M +++ R ++ Sbjct: 134 YSEDFVELNAARYRDED---PRKL---LFTTVPGLTGVCMVVVLFLMITASTYAIRVSNY 187 Query: 1216 RGFWLTHHLYILLYALLIIHGSYALIQLPT 1245 FW TH+L+ + Y LL +H S L++ T Sbjct: 188 DIFWYTHNLFFVFYMLLTLHVSGGLLKYQT 217 >gi|4503595 eosinophil peroxidase [Homo sapiens] Length = 715 Score = 124 bits (311), Expect = 7e-28 Identities = 149/546 (27%), Positives = 240/546 (43%), Gaps = 61/546 (11%) Query: 40 GWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRR------LSNAATRGIA 93 G NN R GA L R +PA Y DG+ +L P+ RR L A + I Sbjct: 150 GRCNNKRRPLLGASNQALARWLPAEYEDGL--SLPFGWTPSRRRNGFLLPLVRAVSNQIV 207 Query: 94 GLP-----SLHNRTVLGVFFGYHVLSDV-VSVETPGCPA---------------EFLNIR 132 P S R ++ + +G + D+ S E+P A I+ Sbjct: 208 RFPNERLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFTAGVDCERTCAQLPPCFPIK 267 Query: 133 IPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWS 192 IPP DP +QR +PF RS P ++ + R+ N +T ++D S +YGS S S Sbjct: 268 IPPNDPRIK-NQRD--CIPFFRSA--PSCPQNKNRVRNQINALTSFVDASMVYGSEVSLS 322 Query: 193 DALRSFSGGQLASGPDPAFPRDSQNPLLMW--AAPDPATGQNGPRGLYAF--GAERGNRE 248 LR+ + + F +D+ LL + DP N + F G R Sbjct: 323 LRLRNRTNYLGLLAINQRF-QDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSTET 381 Query: 249 PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL-- 306 P L A+ L+ R HN A L R +P W ++L+ ARK + A Q I ++LP L Sbjct: 382 PKLAAMHTLFMREHNRLATELRRLNPRWNGDKLYNEARKIMGAMVQIITYRDFLPLVLGK 441 Query: 307 ---QKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQS 363 ++TL Y GY +DP ++ F +A +F TM+ P ++ R S + N Sbjct: 442 ARARRTLGHYRGYCSNVDPRVANVFTLAF-RFGHTMLQPFMF-RLDSQYRASAPNSHVPL 499 Query: 364 SQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISEL--EDNIVVEDLRDYWPGPGKFS 421 S A W + ++ +L G+ + ++L +D ++V++LRD + Sbjct: 500 SSAFFAS---W-----RIVYEGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFRQVRRI 551 Query: 422 RTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLSQ 481 D A ++QR RD GLP Y+ GL PRN + L+ + Q L Sbjct: 552 GLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLNLYGTPDN 611 Query: 482 LELLLGGLLE---SHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNT 538 +++ +G + E GPL + + +QF R RDGDR+W++ + G+F+K++ + + Sbjct: 612 IDIWIGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWWQ--KRGVFTKRQRKALSRI 669 Query: 539 TLRDVL 544 +L ++ Sbjct: 670 SLSRII 675 >gi|28558982 thyroid peroxidase isoform a [Homo sapiens] Length = 933 Score = 120 bits (300), Expect = 1e-26 Identities = 118/430 (27%), Positives = 191/430 (44%), Gaps = 48/430 (11%) Query: 146 GDVVLPFQRSRWDPETGR--------SPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRS 197 G LPF RS TG S +NPR N +T +LD S +YGSS + LR+ Sbjct: 283 GTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRN 342 Query: 198 FSGGQLASGPDPAFPRDSQNPLLMWA--------APDPATGQNGPRGLYAFGAERGNREP 249 ++ + RDS L + AP+P + G R + P Sbjct: 343 WTSAEGLLRVHARL-RDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVP 401 Query: 250 FLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL--- 306 L AL LW R HN A L + W + ++Q ARK V A +Q I + +++P L Sbjct: 402 SLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPE 461 Query: 307 --QKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSS 364 Q+ + Y GY +P++S F A+ +F + P V +AS FQ Sbjct: 462 AFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDAS----------FQEH 511 Query: 365 QALRVCNNYWIRE---NP-NLNSTQEVNELLLGMASQISEL--EDNIVVEDLRDYWPGPG 418 L W+ + +P L ++ L+ G+ ++ ++L +D ++ E+L + Sbjct: 512 PDL---PGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLS 568 Query: 419 KFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNV-DPQVLEATAALYNQ 477 S D + ++QRGRD GLP Y++ GL +DL+ + V + LY Sbjct: 569 NSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKH 628 Query: 478 DLSQLELLLGGLLES---HGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIED 534 +++ LGGL E+ GPLF+ ++ Q LRDGD +W+EN+ +F+ + + Sbjct: 629 P-DNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSH--VFTDAQRRE 685 Query: 535 IRNTTLRDVL 544 + +L V+ Sbjct: 686 LEKHSLSRVI 695 >gi|28558988 thyroid peroxidase isoform d [Homo sapiens] Length = 889 Score = 120 bits (300), Expect = 1e-26 Identities = 118/430 (27%), Positives = 191/430 (44%), Gaps = 48/430 (11%) Query: 146 GDVVLPFQRSRWDPETGR--------SPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRS 197 G LPF RS TG S +NPR N +T +LD S +YGSS + LR+ Sbjct: 283 GTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRN 342 Query: 198 FSGGQLASGPDPAFPRDSQNPLLMWA--------APDPATGQNGPRGLYAFGAERGNREP 249 ++ + RDS L + AP+P + G R + P Sbjct: 343 WTSAEGLLRVHARL-RDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVP 401 Query: 250 FLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL--- 306 L AL LW R HN A L + W + ++Q ARK V A +Q I + +++P L Sbjct: 402 SLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPE 461 Query: 307 --QKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSS 364 Q+ + Y GY +P++S F A+ +F + P V +AS FQ Sbjct: 462 AFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDAS----------FQEH 511 Query: 365 QALRVCNNYWIRE---NP-NLNSTQEVNELLLGMASQISEL--EDNIVVEDLRDYWPGPG 418 L W+ + +P L ++ L+ G+ ++ ++L +D ++ E+L + Sbjct: 512 PDL---PGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLS 568 Query: 419 KFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNV-DPQVLEATAALYNQ 477 S D + ++QRGRD GLP Y++ GL +DL+ + V + LY Sbjct: 569 NSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKH 628 Query: 478 DLSQLELLLGGLLES---HGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIED 534 +++ LGGL E+ GPLF+ ++ Q LRDGD +W+EN+ +F+ + + Sbjct: 629 P-DNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSH--VFTDAQRRE 685 Query: 535 IRNTTLRDVL 544 + +L V+ Sbjct: 686 LEKHSLSRVI 695 >gi|231569458 lactoperoxidase isoform 3 preproprotein [Homo sapiens] Length = 629 Score = 119 bits (298), Expect = 2e-26 Identities = 154/594 (25%), Positives = 250/594 (42%), Gaps = 92/594 (15%) Query: 8 ALMLLGALLTGSLGPSGNQDALSL------PWEVQRYD---------GWFNNLRHHERGA 52 +L+LL A + + PS + +LSL P V R D G NN R GA Sbjct: 13 SLILLQAAASTTRDPSLDLTSLSLEVGCGAPAPVVRCDPCSPYRTITGDCNNRRKPALGA 72 Query: 53 VGCRLQRRVPANYADGVY--------QALEEPQLPNPRRLSNAATRGIAGLPSL-HNRTV 103 L R +PA Y DG+ + LP R +SN + L NR++ Sbjct: 73 ANRALARWLPAEYEDGLSLPFGWTPGKTRNGFPLPLAREVSNKIVGYLNEEGVLDQNRSL 132 Query: 104 LGVFFGYHVLSDV-VSVETPGCPAEFLN---------------IRIPPGDPVFDPDQRGD 147 L + +G V D+ + +T +E+ I PP DP + Sbjct: 133 LFMQWGQIVDHDLDFAPDTELGSSEYSKAQCDEYCIQGDNCFPIMFPPNDPKAGTQGK-- 190 Query: 148 VVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSG--GQLAS 205 +PF R+ + T S R+ N +T +LD S +Y S S + LR+ S G +A Sbjct: 191 -CMPFFRAGFVCPTPPYKSLAREQINALTSFLDASFVYSSEPSLASRLRNLSSPLGLMAV 249 Query: 206 GPD------PAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWF 259 + P P DS+ P +P + G R + L L+ Sbjct: 250 NQEVSDHGLPYLPYDSKKP-----SPCEFINTTARVPCFLAGDSRASEHILLATSHTLFL 304 Query: 260 RYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL----QKTLPEYTG 315 R HN A+ L R +P W+ E+L+Q ARK + A Q I ++LP L QK +P Y G Sbjct: 305 REHNRLARELKRLNPQWDGEKLYQEARKILGAFVQIITFRDYLPILLGDHMQKWIPPYQG 364 Query: 316 YRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQ------SSQALRV 369 Y +DP IS F A +F VP ++ L++ +Q + Sbjct: 365 YSESVDPRISNVFTFAF-RFGHLEVPSSMFR----------LDENYQPWGPEPELPLHTL 413 Query: 370 CNNYWIRENPNLNSTQEVNELLLGMASQISEL--EDNIVVEDLRDYWPGP-GKFSRTDYV 426 N W + ++ L+ G+ ++ S+L ++ ++ +LR+ P + D Sbjct: 414 FFNTW-----RMVKDGGIDPLVRGLLAKKSKLMKQNKMMTGELRNKLFQPTHRIHGFDLA 468 Query: 427 ASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVL-EATAALYNQDLSQLELL 485 A + QR RD G P Y+ L P+ +LN + ++L + LY +++ Sbjct: 469 AINTQRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKKLLGLYGTP-DNIDIW 527 Query: 486 LGGLLE---SHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIR 536 +G + E G GPL + ++ QF ++RDGDR+W+EN G+F+ ++ + ++ Sbjct: 528 IGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENP--GVFTNEQKDSLQ 579 >gi|40549418 lactoperoxidase isoform 1 preproprotein [Homo sapiens] Length = 712 Score = 117 bits (294), Expect = 7e-26 Identities = 153/588 (26%), Positives = 245/588 (41%), Gaps = 92/588 (15%) Query: 14 ALLTGSLGPSGNQDALSL------PWEVQRYD---------GWFNNLRHHERGAVGCRLQ 58 A LT PS + +LSL P V R D G NN R GA L Sbjct: 102 ASLTNVTDPSLDLTSLSLEVGCGAPAPVVRCDPCSPYRTITGDCNNRRKPALGAANRALA 161 Query: 59 RRVPANYADGVY--------QALEEPQLPNPRRLSNAATRGIAGLPSL-HNRTVLGVFFG 109 R +PA Y DG+ + LP R +SN + L NR++L + +G Sbjct: 162 RWLPAEYEDGLSLPFGWTPGKTRNGFPLPLAREVSNKIVGYLNEEGVLDQNRSLLFMQWG 221 Query: 110 YHVLSDV-VSVETPGCPAEFLN---------------IRIPPGDPVFDPDQRGDVVLPFQ 153 V D+ + +T +E+ I PP DP + +PF Sbjct: 222 QIVDHDLDFAPDTELGSSEYSKAQCDEYCIQGDNCFPIMFPPNDPKAGTQGK---CMPFF 278 Query: 154 RSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSG--GQLASGPD--- 208 R+ + T S R+ N +T +LD S +Y S S + LR+ S G +A + Sbjct: 279 RAGFVCPTPPYKSLAREQINALTSFLDASFVYSSEPSLASRLRNLSSPLGLMAVNQEVSD 338 Query: 209 ---PAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLW 265 P P DS+ P +P + G R + L L+ R HN Sbjct: 339 HGLPYLPYDSKKP-----SPCEFINTTARVPCFLAGDSRASEHILLATSHTLFLREHNRL 393 Query: 266 AQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL----QKTLPEYTGYRPFLD 321 A+ L R +P W+ E+L+Q ARK + A Q I ++LP L QK +P Y GY +D Sbjct: 394 ARELKRLNPQWDGEKLYQEARKILGAFVQIITFRDYLPILLGDHMQKWIPPYQGYSESVD 453 Query: 322 PSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQ------SSQALRVCNNYWI 375 P IS F A +F VP ++ L++ +Q + N W Sbjct: 454 PRISNVFTFAF-RFGHLEVPSSMFR----------LDENYQPWGPEPELPLHTLFFNTW- 501 Query: 376 RENPNLNSTQEVNELLLGMASQISEL--EDNIVVEDLRDYWPGP-GKFSRTDYVASSIQR 432 + ++ L+ G+ ++ S+L ++ ++ +LR+ P + D A + QR Sbjct: 502 ----RMVKDGGIDPLVRGLLAKKSKLMKQNKMMTGELRNKLFQPTHRIHGFDLAAINTQR 557 Query: 433 GRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVL-EATAALYNQDLSQLELLLGGLLE 491 RD G P Y+ L P+ +LN + ++L + LY +++ +G + E Sbjct: 558 CRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKKLLGLYGTP-DNIDIWIGAIAE 616 Query: 492 ---SHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIR 536 G GPL + ++ QF ++RDGDR+W+EN G+F+ ++ + ++ Sbjct: 617 PLVERGRVGPLLACLLGKQFQQIRDGDRFWWENP--GVFTNEQKDSLQ 662 >gi|4557759 myeloperoxidase [Homo sapiens] Length = 745 Score = 115 bits (287), Expect = 4e-25 Identities = 142/559 (25%), Positives = 232/559 (41%), Gaps = 87/559 (15%) Query: 40 GWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRR------LSNAATRGIA 93 G NN R GA R +PA Y DG +L P +R L+ A + I Sbjct: 178 GMCNNRRSPTLGASNRAFVRWLPAEYEDGF--SLPYGWTPGVKRNGFPVALARAVSNEIV 235 Query: 94 GLPSLH-----NRTVLGVFFGYHVLSDVVSVETPGCPAEFLN----------------IR 132 P+ R+++ + +G + D+ P A F+ ++ Sbjct: 236 RFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLK 295 Query: 133 IPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWS 192 IPP DP + D + PF RS P S R+ N +T ++D S +YGS + Sbjct: 296 IPPNDPRIK--NQADCI-PFFRSC--PACPGSNITIRNQINALTSFVDASMVYGSEEPLA 350 Query: 193 DALRSFSGGQLASGPDPAFPRDSQNPLLMW--AAPDPATGQNGPRGLYAF--GAERGNRE 248 LR+ S + F +D+ LL + DP N + F G R + Sbjct: 351 RNLRNMSNQLGLLAVNQRF-QDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEM 409 Query: 249 PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWL-----P 303 P L ++ L R HN A L +P W+ E L+Q ARK V A Q I ++L P Sbjct: 410 PELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGP 469 Query: 304 SFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQS 363 + ++K LP Y Y +DP I+ F A ++ T++ P ++ Sbjct: 470 TAMRKYLPTYRSYNDSVDPRIANVFTNAF-RYGHTLIQPFMF------------------ 510 Query: 364 SQALRVCNNYWIRE-NPNLNSTQ------------EVNELLLGMASQISEL--EDNIVVE 408 R+ N Y E NP + ++ ++ +L G+ + ++L ++ I V+ Sbjct: 511 ----RLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVD 566 Query: 409 DLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVL 468 ++R+ D A ++QR RD GLP Y+ GL P L + L Sbjct: 567 EIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKL 626 Query: 469 EATAALYNQDLSQLELLLGGL---LESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNG 525 + +++ +GG+ L+ G GPL + I+ QF +LRDGDR+W+EN G Sbjct: 627 ARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWEN--EG 684 Query: 526 LFSKKEIEDIRNTTLRDVL 544 +FS ++ + + +L ++ Sbjct: 685 VFSMQQRQALAQISLPRII 703 >gi|219842346 NADPH oxidase 4 isoform b [Homo sapiens] Length = 538 Score = 87.0 bits (214), Expect = 1e-16 Identities = 68/319 (21%), Positives = 129/319 (40%), Gaps = 76/319 (23%) Query: 1244 PTFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWV 1303 P ++ P +Y ++L R ++++ PS V ++ + + F+ + GQ++ Sbjct: 281 PQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVISHPSDVMEIRMVK-ENFKARPGQYI 339 Query: 1304 RIACLALGTTEYHPFTLTSAPHED--TLSLHIRAVGPWTTRLREIYSSPKGNG------- 1354 + C ++ E HPFTLT P E T +H++ VG WT R R++ P Sbjct: 340 TLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFI 399 Query: 1355 -CAGYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKK 1413 YPK +W +++ ++ Sbjct: 400 QSRNYPK-----------DDWKPYKL--------------------------------RR 416 Query: 1414 IYFIWVTRTQRQFEWLADII----QEVEENDHQDLVSVHIYVTQLAEKFDLRTTMLYICE 1469 +YFIWV R + F W AD++ + + + D V++ +Y++Q Sbjct: 417 LYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQ---------------T 461 Query: 1470 RHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKA 1529 QK++ + L S GRP ++ F+ + + + + + +GVF CGP ++K + K Sbjct: 462 DGIQKIIGEK-YHALNSRLFIGRPRWKLLFDEIAK-YNRGKTVGVFCCGPNSLSKTLHKL 519 Query: 1530 CQLVNRQDRAHFMHHYENF 1548 N F ++ E+F Sbjct: 520 SN-QNNSYGTRFEYNKESF 537 Score = 80.1 bits (196), Expect = 2e-14 Identities = 60/210 (28%), Positives = 104/210 (49%), Gaps = 16/210 (7%) Query: 1043 VCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTAASVSFMFSYILLTMC 1102 +C+ I+ ++ V +F Y + Q +G+ LSR +A+ ++ S ILL MC Sbjct: 17 LCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMC 76 Query: 1103 RNLITFLRETFLNRYVP-------FDAAVDFHRWIAMAAVVLAILHSAGHAVNVYIFSVS 1155 R L+ +LR + + VP D + FH + + + +H A H VN FSV+ Sbjct: 77 RTLLAYLRGS---QKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHVAAHLVNALNFSVN 133 Query: 1156 PLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLAIMYVFASHHFRRRSF 1215 + + ++ P+K F TVPG+TGV +++VL +M +++ R ++ Sbjct: 134 YSEDFVELNAARYRDED---PRKL---LFTTVPGLTGVCMVVVLFLMITASTYAIRVSNY 187 Query: 1216 RGFWLTHHLYILLYALLIIHGSYALIQLPT 1245 FW TH+L+ + Y LL +H S L++ T Sbjct: 188 DIFWYTHNLFFVFYMLLTLHVSGGLLKYQT 217 >gi|28558984 thyroid peroxidase isoform b [Homo sapiens] Length = 876 Score = 79.3 bits (194), Expect = 3e-14 Identities = 67/226 (29%), Positives = 98/226 (43%), Gaps = 22/226 (9%) Query: 146 GDVVLPFQRSRWDPETGR--------SPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRS 197 G LPF RS TG S +NPR N +T +LD S +YGSS + LR+ Sbjct: 283 GTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRN 342 Query: 198 FSGGQLASGPDPAFPRDSQNPLLMWA--------APDPATGQNGPRGLYAFGAERGNREP 249 ++ + RDS L + AP+P + G R + P Sbjct: 343 WTSAEGLLRVHARL-RDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVP 401 Query: 250 FLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL--- 306 L AL LW R HN A L + W + ++Q ARK V A +Q I + +++P L Sbjct: 402 SLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPE 461 Query: 307 --QKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNAS 350 Q+ + Y GY +P++S F A+ +F + P V +AS Sbjct: 462 AFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDAS 507 >gi|40254415 guanylate cyclase activator 1A (retina) [Homo sapiens] Length = 201 Score = 65.9 bits (159), Expect = 3e-10 Identities = 40/125 (32%), Positives = 65/125 (52%), Gaps = 6/125 (4%) Query: 805 ELSRAEFAESLGLK----PQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEDKS 860 +L+ EF + GLK +VE MF D + +GY+ F E++ L + +KG E K Sbjct: 33 QLTLYEFRQFFGLKNLSPSASQYVEQMFETFDFNKDGYIDFMEYVAALSLVLKGKVEQKL 92 Query: 861 RLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLA-EVVESMFRESGFQDKEEL 919 R F +YD+D NG + +DE T++++ I N C A E +++F + EL Sbjct: 93 RWYFKLYDVDGNGCIDRDELLTIIQA-IRAINPCSDTTMTAEEFTDTVFSKIDVNGDGEL 151 Query: 920 TWEDF 924 + E+F Sbjct: 152 SLEEF 156 >gi|28558990 thyroid peroxidase isoform e [Homo sapiens] Length = 760 Score = 65.5 bits (158), Expect = 4e-10 Identities = 65/252 (25%), Positives = 117/252 (46%), Gaps = 26/252 (10%) Query: 303 PSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQ 362 P Q+ + Y GY +P++S F A+ +F + P V +AS FQ Sbjct: 287 PEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDAS----------FQ 336 Query: 363 SSQALRVCNNYWIRE---NP-NLNSTQEVNELLLGMASQISELE--DNIVVEDLRDYWPG 416 L W+ + +P L ++ L+ G+ ++ ++L+ D ++ E+L + Sbjct: 337 EHPDLP---GLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFV 393 Query: 417 PGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQ-VLEATAALY 475 S D + ++QRGRD GLP Y++ GL +DL+ + + V + LY Sbjct: 394 LSNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLY 453 Query: 476 NQDLSQLELLLGGLLES---HGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEI 532 +++ LGGL E+ GPLF+ ++ Q LRDGD +W+EN+ +F+ + Sbjct: 454 KHP-DNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSH--VFTDAQR 510 Query: 533 EDIRNTTLRDVL 544 ++ +L V+ Sbjct: 511 RELEKHSLSRVI 522 >gi|4506025 protein phosphatase 3, regulatory subunit B, alpha isoform 1 [Homo sapiens] Length = 170 Score = 62.4 bits (150), Expect = 3e-09 Identities = 37/120 (30%), Positives = 65/120 (54%), Gaps = 5/120 (4%) Query: 806 LSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVF-MKGSPEDKSRLMF 864 LS EF SL Q+ V+ + + D DGNG + F+EF++ + F +KG E K R F Sbjct: 38 LSVEEFM-SLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAF 96 Query: 865 TMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDF 924 +YD+D++G++S E F +++ + N L QL ++V+ + +++E+F Sbjct: 97 RIYDMDKDGYISNGELFQVLKMMV---GNNLKDTQLQQIVDKTIINADKDGDGRISFEEF 153 >gi|13375787 EF-hand calcium binding domain 1 isoform a [Homo sapiens] Length = 211 Score = 60.5 bits (145), Expect = 1e-08 Identities = 44/142 (30%), Positives = 72/142 (50%), Gaps = 18/142 (12%) Query: 799 REALTCELSRAEFAESLGLK---PQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGS 855 R+ L L R F L + DM ++ +F DKD +G ++ E++ L +F++GS Sbjct: 41 RQGLVVGLDRNAFRNILHVTFGMTDDMIMDRVFRGFDKDNDGCVNVLEWIHGLSLFLRGS 100 Query: 856 PEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQD 915 E+K + F ++DL+ +GF+SK+E F M++ N L K E + G +D Sbjct: 101 LEEKMKYCFEVFDLNGDGFISKEEMFHMLK-------NSLLKQPSEE-----DPDEGIKD 148 Query: 916 KEELTWEDFHFMLRDHDSELRF 937 E+T + M DHD +L F Sbjct: 149 LVEITLKK---MDHDHDGKLSF 167 >gi|98985795 neurocalcin delta [Homo sapiens] Length = 193 Score = 60.1 bits (144), Expect = 2e-08 Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 8/150 (5%) Query: 798 VREALTCELSRAEFAESLG----LKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMK 853 +R+ + LS EF + G F E +F D +G+G + FREF+ L V + Sbjct: 35 LRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALSVTSR 94 Query: 854 GSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCL----SKAQLAEVVESMFR 909 G E K + F+MYDLD NG++SK E ++++ ++ ++ + ++ + E +FR Sbjct: 95 GKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFR 154 Query: 910 ESGFQDKEELTWEDFHFMLRDHDSELRFTQ 939 + +L+ E+F + S +R Q Sbjct: 155 QMDTNRDGKLSLEEFIRGAKSDPSIVRLLQ 184 >gi|98985793 neurocalcin delta [Homo sapiens] Length = 193 Score = 60.1 bits (144), Expect = 2e-08 Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 8/150 (5%) Query: 798 VREALTCELSRAEFAESLG----LKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMK 853 +R+ + LS EF + G F E +F D +G+G + FREF+ L V + Sbjct: 35 LRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALSVTSR 94 Query: 854 GSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCL----SKAQLAEVVESMFR 909 G E K + F+MYDLD NG++SK E ++++ ++ ++ + ++ + E +FR Sbjct: 95 GKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFR 154 Query: 910 ESGFQDKEELTWEDFHFMLRDHDSELRFTQ 939 + +L+ E+F + S +R Q Sbjct: 155 QMDTNRDGKLSLEEFIRGAKSDPSIVRLLQ 184 >gi|98985791 neurocalcin delta [Homo sapiens] Length = 193 Score = 60.1 bits (144), Expect = 2e-08 Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 8/150 (5%) Query: 798 VREALTCELSRAEFAESLG----LKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMK 853 +R+ + LS EF + G F E +F D +G+G + FREF+ L V + Sbjct: 35 LRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALSVTSR 94 Query: 854 GSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCL----SKAQLAEVVESMFR 909 G E K + F+MYDLD NG++SK E ++++ ++ ++ + ++ + E +FR Sbjct: 95 GKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFR 154 Query: 910 ESGFQDKEELTWEDFHFMLRDHDSELRFTQ 939 + +L+ E+F + S +R Q Sbjct: 155 QMDTNRDGKLSLEEFIRGAKSDPSIVRLLQ 184 >gi|98985789 neurocalcin delta [Homo sapiens] Length = 193 Score = 60.1 bits (144), Expect = 2e-08 Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 8/150 (5%) Query: 798 VREALTCELSRAEFAESLG----LKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMK 853 +R+ + LS EF + G F E +F D +G+G + FREF+ L V + Sbjct: 35 LRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALSVTSR 94 Query: 854 GSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCL----SKAQLAEVVESMFR 909 G E K + F+MYDLD NG++SK E ++++ ++ ++ + ++ + E +FR Sbjct: 95 GKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFR 154 Query: 910 ESGFQDKEELTWEDFHFMLRDHDSELRFTQ 939 + +L+ E+F + S +R Q Sbjct: 155 QMDTNRDGKLSLEEFIRGAKSDPSIVRLLQ 184 >gi|98985787 neurocalcin delta [Homo sapiens] Length = 193 Score = 60.1 bits (144), Expect = 2e-08 Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 8/150 (5%) Query: 798 VREALTCELSRAEFAESLG----LKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMK 853 +R+ + LS EF + G F E +F D +G+G + FREF+ L V + Sbjct: 35 LRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALSVTSR 94 Query: 854 GSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCL----SKAQLAEVVESMFR 909 G E K + F+MYDLD NG++SK E ++++ ++ ++ + ++ + E +FR Sbjct: 95 GKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFR 154 Query: 910 ESGFQDKEELTWEDFHFMLRDHDSELRFTQ 939 + +L+ E+F + S +R Q Sbjct: 155 QMDTNRDGKLSLEEFIRGAKSDPSIVRLLQ 184 >gi|98985785 neurocalcin delta [Homo sapiens] Length = 193 Score = 60.1 bits (144), Expect = 2e-08 Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 8/150 (5%) Query: 798 VREALTCELSRAEFAESLG----LKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMK 853 +R+ + LS EF + G F E +F D +G+G + FREF+ L V + Sbjct: 35 LRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALSVTSR 94 Query: 854 GSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCL----SKAQLAEVVESMFR 909 G E K + F+MYDLD NG++SK E ++++ ++ ++ + ++ + E +FR Sbjct: 95 GKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFR 154 Query: 910 ESGFQDKEELTWEDFHFMLRDHDSELRFTQ 939 + +L+ E+F + S +R Q Sbjct: 155 QMDTNRDGKLSLEEFIRGAKSDPSIVRLLQ 184 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.323 0.139 0.433 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 63,572,378 Number of Sequences: 37866 Number of extensions: 3168351 Number of successful extensions: 9531 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 98 Number of HSP's successfully gapped in prelim test: 53 Number of HSP's that attempted gapping in prelim test: 9140 Number of HSP's gapped (non-prelim): 289 length of query: 1548 length of database: 18,247,518 effective HSP length: 115 effective length of query: 1433 effective length of database: 13,892,928 effective search space: 19908565824 effective search space used: 19908565824 T: 11 A: 40 X1: 16 ( 7.5 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (22.0 bits) S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.