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Search of human proteins with 13236495
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13236495 crystallin, zeta isoform a [Homo sapiens]
(329 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194239674 crystallin, zeta isoform a [Homo sapiens] 647 0.0
gi|13236495 crystallin, zeta isoform a [Homo sapiens] 647 0.0
gi|194239676 crystallin, zeta isoform b [Homo sapiens] 566 e-162
gi|197927207 crystallin, zeta isoform c [Homo sapiens] 367 e-102
gi|18379349 vesicle amine transport protein 1 [Homo sapiens] 159 3e-39
gi|24308257 vesicle amine transport protein 1 homolog (T. califo... 154 8e-38
gi|22538446 tumor protein p53 inducible protein 3 [Homo sapiens] 114 9e-26
gi|22538444 tumor protein p53 inducible protein 3 [Homo sapiens] 114 9e-26
gi|47519420 reticulon 4 interacting protein 1 precursor [Homo sa... 93 4e-19
gi|41872631 fatty acid synthase [Homo sapiens] 86 3e-17
gi|67078404 trans-2-enoyl-CoA reductase, mitochondrial isoform a... 80 3e-15
gi|28557745 zinc binding alcohol dehydrogenase domain containing... 75 8e-14
gi|67078406 trans-2-enoyl-CoA reductase, mitochondrial isoform b... 75 1e-13
gi|90669511 crystallin, zeta-like 1 [Homo sapiens] 69 6e-12
gi|226059159 prostaglandin reductase 1 isoform 1 [Homo sapiens] 68 1e-11
gi|226059133 prostaglandin reductase 1 isoform 1 [Homo sapiens] 68 1e-11
gi|226056130 prostaglandin reductase 1 isoform 2 [Homo sapiens] 68 1e-11
gi|156627571 sorbitol dehydrogenase [Homo sapiens] 62 5e-10
gi|4501929 class I alcohol dehydrogenase, alpha subunit [Homo sa... 61 1e-09
gi|34577061 class I alcohol dehydrogenase, beta subunit [Homo sa... 60 3e-09
gi|71565154 class III alcohol dehydrogenase, chi subunit [Homo s... 58 1e-08
gi|4501933 class I alcohol dehydrogenase, gamma subunit [Homo sa... 57 2e-08
gi|156523966 class V alcohol dehydrogenase isoform 1 [Homo sapiens] 57 2e-08
gi|4501939 class V alcohol dehydrogenase isoform 2 [Homo sapiens] 57 2e-08
gi|71743840 class IV alcohol dehydrogenase, mu or sigma subunit ... 52 7e-07
gi|71565152 class II alcohol dehydrogenase, pi subunit [Homo sap... 42 6e-04
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 35 0.12
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens] 31 1.3
gi|40538880 aquaporin 12A [Homo sapiens] 30 3.9
gi|10863929 ribonuclease L [Homo sapiens] 28 8.6
>gi|194239674 crystallin, zeta isoform a [Homo sapiens]
Length = 329
Score = 647 bits (1670), Expect = 0.0
Identities = 329/329 (100%), Positives = 329/329 (100%)
Query: 1 MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS 60
MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS
Sbjct: 1 MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS 60
Query: 61 RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEK 120
RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEK
Sbjct: 61 RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEK 120
Query: 121 LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA 180
LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA
Sbjct: 121 LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA 180
Query: 181 GTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG 240
GTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG
Sbjct: 181 GTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG 240
Query: 241 GRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG 300
GRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG
Sbjct: 241 GRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG 300
Query: 301 SQYPLEKVAEAHENIIHGSGATGKMILLL 329
SQYPLEKVAEAHENIIHGSGATGKMILLL
Sbjct: 301 SQYPLEKVAEAHENIIHGSGATGKMILLL 329
>gi|13236495 crystallin, zeta isoform a [Homo sapiens]
Length = 329
Score = 647 bits (1670), Expect = 0.0
Identities = 329/329 (100%), Positives = 329/329 (100%)
Query: 1 MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS 60
MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS
Sbjct: 1 MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS 60
Query: 61 RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEK 120
RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEK
Sbjct: 61 RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEK 120
Query: 121 LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA 180
LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA
Sbjct: 121 LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA 180
Query: 181 GTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG 240
GTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG
Sbjct: 181 GTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG 240
Query: 241 GRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG 300
GRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG
Sbjct: 241 GRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG 300
Query: 301 SQYPLEKVAEAHENIIHGSGATGKMILLL 329
SQYPLEKVAEAHENIIHGSGATGKMILLL
Sbjct: 301 SQYPLEKVAEAHENIIHGSGATGKMILLL 329
>gi|194239676 crystallin, zeta isoform b [Homo sapiens]
Length = 295
Score = 566 bits (1459), Expect = e-162
Identities = 295/329 (89%), Positives = 295/329 (89%), Gaps = 34/329 (10%)
Query: 1 MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS 60
MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS
Sbjct: 1 MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS 60
Query: 61 RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEK 120
RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEK
Sbjct: 61 RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEK 120
Query: 121 LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA 180
LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA
Sbjct: 121 LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA 180
Query: 181 GTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG 240
GTEEGQKIVLQNGAHEVFNHREVNYIDKIK
Sbjct: 181 GTEEGQKIVLQNGAHEVFNHREVNYIDKIK------------------------------ 210
Query: 241 GRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG 300
VVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG
Sbjct: 211 ----VVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG 266
Query: 301 SQYPLEKVAEAHENIIHGSGATGKMILLL 329
SQYPLEKVAEAHENIIHGSGATGKMILLL
Sbjct: 267 SQYPLEKVAEAHENIIHGSGATGKMILLL 295
>gi|197927207 crystallin, zeta isoform c [Homo sapiens]
Length = 192
Score = 367 bits (943), Expect = e-102
Identities = 188/190 (98%), Positives = 189/190 (99%)
Query: 140 LIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFN 199
L+ SACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFN
Sbjct: 3 LLSSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFN 62
Query: 200 HREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDT 259
HREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDT
Sbjct: 63 HREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDT 122
Query: 260 MAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGS 319
MAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGS
Sbjct: 123 MAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGS 182
Query: 320 GATGKMILLL 329
GATGKMILLL
Sbjct: 183 GATGKMILLL 192
>gi|18379349 vesicle amine transport protein 1 [Homo sapiens]
Length = 393
Score = 159 bits (402), Expect = 3e-39
Identities = 111/349 (31%), Positives = 176/349 (50%), Gaps = 26/349 (7%)
Query: 2 ATGQKLMRAVRVFEFGGPEVLKLRS-DIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS 60
A L+R + + FGG + +KL+S A P P Q+ +++ ACG+N + R G Y
Sbjct: 42 AASPPLLRCLVLTGFGGYDKVKLQSRPAAPPAPGPGQLTLRLRACGLNFADLMARQGLYD 101
Query: 61 RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEK 120
R P LP TPG + AGV+ AVG+ S K GDRV + SG + E + +PE
Sbjct: 102 RLPPLPVTPGMEGAGVVIAVGEGVSDRKAGDRVMVLNR-SGMWQEEVTVPSVQTFLIPEA 160
Query: 121 LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAY-GLKILGT 179
+ F++ AA+ + Y TAY L ++ G SVLVH A+GGVG+AA Q+ R + + GT
Sbjct: 161 MTFEEAAALLVNYITAYMVLFDFGNLQPGHSVLVHMAAGGVGMAAVQLCRTVENVTVFGT 220
Query: 180 AGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSH 239
A + + + +NG ++ +Y+D+IKK + KG+DI+++ L + +K +LL
Sbjct: 221 ASASK-HEALKENGVTHPIDYHTTDYVDEIKK-ISPKGVDIVMDPLGGSDTAKGYNLLKP 278
Query: 240 GGRVIVVGSRGTIEINPRDTMA------KESSIIGVTLFSSTK--------------EEF 279
G+V+ G + R+ MA + S+ + L + + E
Sbjct: 279 MGKVVTYGMANLLTGPKRNLMALARTWWNQFSVTALQLLQANRAVCGFHLGYLDGEVELV 338
Query: 280 QQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILL 328
A L A G +KP I S +P EKVA+A + + GK++L+
Sbjct: 339 SGVVARLLALYNQGHIKPHIDSVWPFEKVADAMKQMQEKKN-VGKVLLV 386
>gi|24308257 vesicle amine transport protein 1 homolog (T.
californica)-like [Homo sapiens]
Length = 419
Score = 154 bits (390), Expect = 8e-38
Identities = 112/347 (32%), Positives = 176/347 (50%), Gaps = 37/347 (10%)
Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67
MRAV + FGG L+L A+P P+D ++ I+V ACG+N ++ +R G P P
Sbjct: 42 MRAVVLAGFGGLNKLRLFRK-AMPEPQDGELKIRVKACGLNFIDLMVRQGNIDNPPKTPL 100
Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQGA 127
PG + +G++EA+GD+ ++ GDRV + +AE VYK+P+ + F + A
Sbjct: 101 VPGFECSGIVEALGDSVKGYEIGDRVMAFVNYN-AWAEVVCTPVEFVYKIPDDMSFSEAA 159
Query: 128 AIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAY-GLKILGTAGTEEGQ 186
A + + TAY L A ++ G SVLVH A GGVG A Q+ + + GTA T + +
Sbjct: 160 AFPMNFVTAYVMLFEVANLREGMSVLVHSAGGGVGQAVAQLCSTVPNVTVFGTASTFKHE 219
Query: 187 KIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVV 246
I ++ +F+ R +Y+ ++K+ + +G+DI+++ L N K LSLL G I+
Sbjct: 220 AI--KDSVTHLFD-RNADYVQEVKR-ISAEGVDIVLDCLCGDNTGKGLSLLKPLGTYILY 275
Query: 247 GSRGTI------------------EINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQA 288
GS + ++NP + I G +L + F+Q A L
Sbjct: 276 GSSNMVTGETKSFFSFAKSWWQVEKVNPIKLYEENKVIAGFSLLNLL---FKQGRAGLIR 332
Query: 289 GME---IGW-----LKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327
G+ IG +KPV+ S + LE+V EA + IH G GK+IL
Sbjct: 333 GVVEKLIGLYNQKKIKPVVDSLWALEEVKEAMQR-IHDRGNIGKLIL 378
>gi|22538446 tumor protein p53 inducible protein 3 [Homo sapiens]
Length = 332
Score = 114 bits (286), Expect = 9e-26
Identities = 91/332 (27%), Positives = 157/332 (47%), Gaps = 12/332 (3%)
Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67
M AV + GGPE L ++ ++A P P + +VL+KV A +N + R G Y P
Sbjct: 1 MLAVHFDKPGGPENLYVK-EVAKPSPGEGEVLLKVAASALNRADLMQRQGQYDPPPGASN 59
Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQGA 127
G + +G + +G K + GG A+Y + + +PE L Q A
Sbjct: 60 ILGLEASGHVAELGPGCQGHWKIGDTAMALLPGGGQAQYVTVPEGLLMPIPEGLTLTQAA 119
Query: 128 AIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQK 187
AI + TA++ L V+AG+ VL+H GVG AA Q+ R G L TAG+++ +
Sbjct: 120 AIPEAWLTAFQLLHLVGNVQAGDYVLIHAGLSGVGTAAIQLTRMAGAIPLVTAGSQKKLQ 179
Query: 188 IVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVG 247
+ + GA FN+++ ++ + K+ G+++I++ + K+++ L+ GR ++ G
Sbjct: 180 MAEKLGAAAGFNYKKEDFSEATLKFTKGAGVNLILDCIGGSYWEKNVNCLALDGRWVLYG 239
Query: 248 SRGTIEINP---RDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGW-------LKP 297
G +IN + K S+I L S + Q A + + L P
Sbjct: 240 LMGGGDINGPLFSKLLFKRGSLITSLLRSRDNKYKQMLVNAFTEQILPHFSTEGPQRLLP 299
Query: 298 VIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329
V+ YP+ ++ EAH+ + + GK++L L
Sbjct: 300 VLDRIYPVTEIQEAHK-YMEANKNIGKIVLEL 330
>gi|22538444 tumor protein p53 inducible protein 3 [Homo sapiens]
Length = 332
Score = 114 bits (286), Expect = 9e-26
Identities = 91/332 (27%), Positives = 157/332 (47%), Gaps = 12/332 (3%)
Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67
M AV + GGPE L ++ ++A P P + +VL+KV A +N + R G Y P
Sbjct: 1 MLAVHFDKPGGPENLYVK-EVAKPSPGEGEVLLKVAASALNRADLMQRQGQYDPPPGASN 59
Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQGA 127
G + +G + +G K + GG A+Y + + +PE L Q A
Sbjct: 60 ILGLEASGHVAELGPGCQGHWKIGDTAMALLPGGGQAQYVTVPEGLLMPIPEGLTLTQAA 119
Query: 128 AIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQK 187
AI + TA++ L V+AG+ VL+H GVG AA Q+ R G L TAG+++ +
Sbjct: 120 AIPEAWLTAFQLLHLVGNVQAGDYVLIHAGLSGVGTAAIQLTRMAGAIPLVTAGSQKKLQ 179
Query: 188 IVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVG 247
+ + GA FN+++ ++ + K+ G+++I++ + K+++ L+ GR ++ G
Sbjct: 180 MAEKLGAAAGFNYKKEDFSEATLKFTKGAGVNLILDCIGGSYWEKNVNCLALDGRWVLYG 239
Query: 248 SRGTIEINP---RDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGW-------LKP 297
G +IN + K S+I L S + Q A + + L P
Sbjct: 240 LMGGGDINGPLFSKLLFKRGSLITSLLRSRDNKYKQMLVNAFTEQILPHFSTEGPQRLLP 299
Query: 298 VIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329
V+ YP+ ++ EAH+ + + GK++L L
Sbjct: 300 VLDRIYPVTEIQEAHK-YMEANKNIGKIVLEL 330
>gi|47519420 reticulon 4 interacting protein 1 precursor [Homo
sapiens]
Length = 396
Score = 92.8 bits (229), Expect = 4e-19
Identities = 90/358 (25%), Positives = 167/358 (46%), Gaps = 43/358 (12%)
Query: 7 LMRAVRVFEFGGPEVLKLRSDIAVPIPK-DHQVLIKVHACGVNPVETYIRSG------TY 59
+M A + ++G EVL+ ++ +PI ++V++KVHA VNP++ +RSG
Sbjct: 42 VMPAWVIDKYGKNEVLRFTQNMMMPIIHYPNEVIVKVHAASVNPIDVNMRSGYGATALNM 101
Query: 60 SRKPL--------LPYTPGSDVAGVIEAVGDNASAFKKGDRVFTS--STISGGYAEYALA 109
R PL P T G DV+GV+ G + FK GD V+ + G +E+ +
Sbjct: 102 KRDPLHVKIKGEEFPLTLGRDVSGVVMECGLDVKYFKPGDEVWAAVPPWKQGTLSEFVVV 161
Query: 110 ADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVK----AGESVLVHGASGGVGLAA 165
+ + V P+ L Q A++ TA+ A+ + G+ VL+ GASGGVG A
Sbjct: 162 SGNEVSHKPKSLTHTQAASLPYVALTAWSAINKVGGLNDKNCTGKRVLILGASGGVGTFA 221
Query: 166 CQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEML 225
Q+ +A+ + +++ ++V + GA +V +++ + +++K K D I++ +
Sbjct: 222 IQVMKAWDAHVTAVC-SQDASELVRKLGADDVIDYKSGSVEEQLKSL---KPFDFILDNV 277
Query: 226 --ANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEF---- 279
+ + D G + + + + ++ R +A GVT+ S + F
Sbjct: 278 GGSTETWAPDFLKKWSGATYVTLVTPFLLNMD-RLGIADGMLQTGVTVGSKALKHFWKGV 336
Query: 280 -QQYAAALQAG---------MEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327
++A + +G ++ G ++PVI +P KV EA + G A GK ++
Sbjct: 337 HYRWAFFMASGPCLDDIAELVDAGKIRPVIEQTFPFSKVPEAFLKVERGH-ARGKTVI 393
>gi|41872631 fatty acid synthase [Homo sapiens]
Length = 2511
Score = 86.3 bits (212), Expect = 3e-17
Identities = 60/235 (25%), Positives = 116/235 (49%), Gaps = 10/235 (4%)
Query: 102 GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGV 161
G A L + ++ +P ++ A++ + Y TAY AL+ V+ GE++L+H SGGV
Sbjct: 1621 GLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGV 1680
Query: 162 GLAACQIARAYGLKILGTAGTEEGQKIVL----QNGAHEVFNHREVNYIDKIKKYVGEKG 217
G AA IA + G ++ T G+ E + + Q + N R+ ++ + + G KG
Sbjct: 1681 GQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSRDTSFEQHVLWHTGGKG 1740
Query: 218 IDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINP--RDTMAKESSIIGVTL---F 272
+D+++ LA L + L+ GR + +G + +P K + GV L F
Sbjct: 1741 VDLVLNSLAEEKLQASVRCLATHGRFLEIGKFDLSQNHPLGMAIFLKNVTFHGVLLDAFF 1800
Query: 273 SSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327
+ + ++++ A +QAG+ G ++P+ + + +V +A + G GK+++
Sbjct: 1801 NESSADWREVWALVQAGIRDGVVRPLKCTVFHGAQVEDAFRYMAQGK-HIGKVVV 1854
>gi|67078404 trans-2-enoyl-CoA reductase, mitochondrial isoform a
[Homo sapiens]
Length = 373
Score = 79.7 bits (195), Expect = 3e-15
Identities = 62/268 (23%), Positives = 119/268 (44%), Gaps = 15/268 (5%)
Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67
+RA+ G P + ++ + + V +K+ A +NP + + G Y P LP
Sbjct: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPA 102
Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQGA 127
G++ + AVG N + K GD V ++ G + A+ ++ + ++P + + A
Sbjct: 103 VGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAA 162
Query: 128 AIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA-GTEEGQ 186
+G+ TAYR L+ ++ G+SV+ + ++ GVG A QIA A GL+ + + Q
Sbjct: 163 TLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQ 222
Query: 187 KI---VLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRV 243
K+ + GA V E+ + + + + + + ++ L L+ GG +
Sbjct: 223 KLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTM 282
Query: 244 IVVGSRGTIEINPRDTMAKESSIIGVTL 271
+ G MAK+ + V+L
Sbjct: 283 VTYGG-----------MAKQPVVASVSL 299
>gi|28557745 zinc binding alcohol dehydrogenase domain containing 2
[Homo sapiens]
Length = 377
Score = 75.1 bits (183), Expect = 8e-14
Identities = 59/230 (25%), Positives = 103/230 (44%), Gaps = 8/230 (3%)
Query: 20 EVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEA 79
E + L D VP+P D +L++ GVN + +G Y P+ G + G + A
Sbjct: 47 EAVTLSRDCPVPLPGDGDLLVRNRFVGVNASDINYSAGRYDPSVKPPFDIGFEGIGEVVA 106
Query: 80 VGDNASA-FKKGDRVFTSSTISGGYAEYALAADHTVYKLPE-KLDFKQGAAIGIPYFTAY 137
+G +ASA + G V + G +AEY + +P K ++ G TAY
Sbjct: 107 LGLSASARYTVGQAV--AYMAPGSFAEYTVVPASIATPVPSVKPEYLTLLVSGT---TAY 161
Query: 138 RALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEV 197
+L + G+ VLV A+GG G A Q+++ ++GT ++E + G
Sbjct: 162 ISLKELGGLSEGKKVLVTAAAGGTGQFAMQLSKKAKCHVIGTCSSDEKSAFLKSLGCDRP 221
Query: 198 FNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVG 247
N++ + + K +G+D++ E + + L+ GR+IV+G
Sbjct: 222 INYK-TEPVGTVLKQEYPEGVDVVYESVGGAMFDLAVDALATKGRLIVIG 270
>gi|67078406 trans-2-enoyl-CoA reductase, mitochondrial isoform b
[Homo sapiens]
Length = 297
Score = 74.7 bits (182), Expect = 1e-13
Identities = 56/232 (24%), Positives = 104/232 (44%), Gaps = 15/232 (6%)
Query: 44 ACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGY 103
A +NP + + G Y P LP G++ + AVG N + K GD V ++ G +
Sbjct: 3 AAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTW 62
Query: 104 AEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGL 163
A+ ++ + ++P + + A +G+ TAYR L+ ++ G+SV+ + ++ GVG
Sbjct: 63 RTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQ 122
Query: 164 AACQIARAYGLKILGTA-GTEEGQKI---VLQNGAHEVFNHREVNYIDKIKKYVGEKGID 219
A QIA A GL+ + + QK+ + GA V E+ + +
Sbjct: 123 AVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPR 182
Query: 220 IIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTL 271
+ + + + ++ L L+ GG ++ G MAK+ + V+L
Sbjct: 183 LALNCVGGKSSTELLRQLARGGTMVTYGG-----------MAKQPVVASVSL 223
>gi|90669511 crystallin, zeta-like 1 [Homo sapiens]
Length = 349
Score = 68.9 bits (167), Expect = 6e-12
Identities = 61/232 (26%), Positives = 108/232 (46%), Gaps = 20/232 (8%)
Query: 30 VPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKK 89
+P+ +D+ V ++V AC ++ + T + + +K L P G ++AG++ VG S F+
Sbjct: 25 LPVTEDNFVKLQVKACALSQINTKLLAEMKMKKDLFPV--GREIAGIVLDVGSKVSFFQP 82
Query: 90 GDRVFTSSTISG---GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACV 146
D V + G E +H + PEK+ + + A AY AL + + +
Sbjct: 83 DDEVVGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHL 142
Query: 147 KAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEV-----FNHR 201
G+SVL+ + G A Q+A G K++ TA + E K L+ + ++
Sbjct: 143 SPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLE-DKQCLERFRPPIARVIDVSNG 201
Query: 202 EVNYIDKIKKYVGEKGIDIIIEMLANVNL-SKD------LSLLSHGGRVIVV 246
+V+ + + G G+DI+++ A V L SKD L LL H +I +
Sbjct: 202 KVHVAESCLEETGGLGVDIVLD--AGVRLYSKDDEPAVKLQLLPHKHDIITL 251
>gi|226059159 prostaglandin reductase 1 isoform 1 [Homo sapiens]
Length = 329
Score = 68.2 bits (165), Expect = 1e-11
Identities = 50/187 (26%), Positives = 87/187 (46%), Gaps = 12/187 (6%)
Query: 70 GSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKL----PEKLDFKQ 125
G VA V+E+ A KG V S G+ ++++ + KL P+ +
Sbjct: 65 GQQVAKVVESKN---VALPKGTIVLASP----GWTTHSISDGKDLEKLLTEWPDTIPLSL 117
Query: 126 G-AAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEE 184
+G+P TAY L+ VK GE+V+V+ A+G VG QIA+ G K++G G++E
Sbjct: 118 ALGTVGMPGLTAYFGLLEICGVKGGETVMVNAAAGAVGSVVGQIAKLKGCKVVGAVGSDE 177
Query: 185 GQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVI 244
+ + G VFN++ V +++ K G D + + + + + GR+
Sbjct: 178 KVAYLQKLGFDVVFNYKTVESLEETLKKASPDGYDCYFDNVGGEFSNTVIGQMKKFGRIA 237
Query: 245 VVGSRGT 251
+ G+ T
Sbjct: 238 ICGAIST 244
>gi|226059133 prostaglandin reductase 1 isoform 1 [Homo sapiens]
Length = 329
Score = 68.2 bits (165), Expect = 1e-11
Identities = 50/187 (26%), Positives = 87/187 (46%), Gaps = 12/187 (6%)
Query: 70 GSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKL----PEKLDFKQ 125
G VA V+E+ A KG V S G+ ++++ + KL P+ +
Sbjct: 65 GQQVAKVVESKN---VALPKGTIVLASP----GWTTHSISDGKDLEKLLTEWPDTIPLSL 117
Query: 126 G-AAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEE 184
+G+P TAY L+ VK GE+V+V+ A+G VG QIA+ G K++G G++E
Sbjct: 118 ALGTVGMPGLTAYFGLLEICGVKGGETVMVNAAAGAVGSVVGQIAKLKGCKVVGAVGSDE 177
Query: 185 GQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVI 244
+ + G VFN++ V +++ K G D + + + + + GR+
Sbjct: 178 KVAYLQKLGFDVVFNYKTVESLEETLKKASPDGYDCYFDNVGGEFSNTVIGQMKKFGRIA 237
Query: 245 VVGSRGT 251
+ G+ T
Sbjct: 238 ICGAIST 244
>gi|226056130 prostaglandin reductase 1 isoform 2 [Homo sapiens]
Length = 301
Score = 68.2 bits (165), Expect = 1e-11
Identities = 50/187 (26%), Positives = 87/187 (46%), Gaps = 12/187 (6%)
Query: 70 GSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKL----PEKLDFKQ 125
G VA V+E+ A KG V S G+ ++++ + KL P+ +
Sbjct: 65 GQQVAKVVESKN---VALPKGTIVLASP----GWTTHSISDGKDLEKLLTEWPDTIPLSL 117
Query: 126 G-AAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEE 184
+G+P TAY L+ VK GE+V+V+ A+G VG QIA+ G K++G G++E
Sbjct: 118 ALGTVGMPGLTAYFGLLEICGVKGGETVMVNAAAGAVGSVVGQIAKLKGCKVVGAVGSDE 177
Query: 185 GQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVI 244
+ + G VFN++ V +++ K G D + + + + + GR+
Sbjct: 178 KVAYLQKLGFDVVFNYKTVESLEETLKKASPDGYDCYFDNVGGEFSNTVIGQMKKFGRIA 237
Query: 245 VVGSRGT 251
+ G+ T
Sbjct: 238 ICGAIST 244
>gi|156627571 sorbitol dehydrogenase [Homo sapiens]
Length = 357
Score = 62.4 bits (150), Expect = 5e-10
Identities = 82/339 (24%), Positives = 139/339 (41%), Gaps = 47/339 (13%)
Query: 18 GPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVET----YIRSGTYSRKPLLPYTPGSDV 73
GP L+L + +P P ++VL+++H+ G+ + Y R G + K P G +
Sbjct: 16 GPGDLRLEN-YPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKK--PMVLGHEA 72
Query: 74 AGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTV------------------- 114
+G +E VG + K GDRV E+ + +
Sbjct: 73 SGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRF 132
Query: 115 --------YKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAAC 166
YKLP+ + F++GA I P A V G VLV GA G +G+
Sbjct: 133 YKHNAAFCYKLPDNVTFEEGALIE-PLSVGIHACRRGG-VTLGHKVLVCGA-GPIGMVTL 189
Query: 167 QIARAYGL-KILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGI--DIIIE 223
+A+A G +++ T + + GA V + + + +K G+ G ++ IE
Sbjct: 190 LVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIE 249
Query: 224 ML-ANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMA-KESSIIGVTLFSSTKEEFQQ 281
A ++ + GG +++VG + P A +E I GV + +T
Sbjct: 250 CTGAEASIQAGIYATRSGGNLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNT----WP 305
Query: 282 YAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSG 320
A ++ A + +KP++ ++PLEK EA E G G
Sbjct: 306 VAISMLASKSVN-VKPLVTHRFPLEKALEAFETFKKGLG 343
>gi|4501929 class I alcohol dehydrogenase, alpha subunit [Homo
sapiens]
Length = 375
Score = 61.2 bits (147), Expect = 1e-09
Identities = 61/272 (22%), Positives = 111/272 (40%), Gaps = 54/272 (19%)
Query: 27 DIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASA 86
++ V PK H+V IK+ A G+ + ++ SGT LP G + AG++E+VG+ +
Sbjct: 26 EVEVAPPKAHEVRIKMVAVGICGTDDHVVSGTMVTP--LPVILGHEAAGIVESVGEGVTT 83
Query: 87 FKKGDRVF----------------------------TSSTISGG---------------- 102
K GD+V T+ G
Sbjct: 84 VKPGDKVIPLAIPQCGKCRICKNPESNYCLKNDVSNPQGTLQDGTSRFTCRRKPIHHFLG 143
Query: 103 ---YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASG 159
+++Y + ++ V K+ ++ IG + T Y + ++ A V G + V G G
Sbjct: 144 ISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGL-G 202
Query: 160 GVGLAACQIARAYG-LKILGTAGTEEGQKIVLQNGAHEVFNHREVNY-IDKIKKYVGEKG 217
GVGL+A +A G +I+ ++ + GA E N ++ I ++ K + + G
Sbjct: 203 GVGLSAIMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGG 262
Query: 218 IDIIIEMLANVNLSKDLSLLSHG--GRVIVVG 247
+D E++ ++ L H G ++VG
Sbjct: 263 VDFSFEVIGRLDTMMASLLCCHEACGTSVIVG 294
>gi|34577061 class I alcohol dehydrogenase, beta subunit [Homo
sapiens]
Length = 375
Score = 59.7 bits (143), Expect = 3e-09
Identities = 63/284 (22%), Positives = 114/284 (40%), Gaps = 57/284 (20%)
Query: 27 DIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASA 86
D+ V PK ++V IK+ A G+ + ++ SG LP G + AG++E+VG+ +
Sbjct: 26 DVEVAPPKAYEVRIKMVAVGICHTDDHVVSGNLVTP--LPVILGHEAAGIVESVGEGVTT 83
Query: 87 FKKGDRVFTSSTISGG-------------------------------------------- 102
K GD+V T G
Sbjct: 84 VKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLG 143
Query: 103 ---YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASG 159
+++Y + ++ V K+ ++ IG + T Y + ++ A V G + V G G
Sbjct: 144 TSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGL-G 202
Query: 160 GVGLAACQIARAYG-LKILGTAGTEEGQKIVLQNGAHEVFNHREVNY-IDKIKKYVGEKG 217
GVGL+A +A G +I+ ++ + GA E N ++ I ++ K + + G
Sbjct: 203 GVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGG 262
Query: 218 IDIIIEMLANVNLSKDLSLLSHG--GRVIVVG---SRGTIEINP 256
+D E++ ++ L H G ++VG + + INP
Sbjct: 263 VDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINP 306
>gi|71565154 class III alcohol dehydrogenase, chi subunit [Homo
sapiens]
Length = 374
Score = 57.8 bits (138), Expect = 1e-08
Identities = 68/284 (23%), Positives = 113/284 (39%), Gaps = 58/284 (20%)
Query: 9 RAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYT 68
+A +E G P ++ +I V PK H+V IK+ A V + Y SG + P
Sbjct: 9 KAAVAWEAGKPLSIE---EIEVAPPKAHEVRIKIIATAVCHTDAYTLSGA-DPEGCFPVI 64
Query: 69 PGSDVAGVIEAVGDNASAFKKGDRVF---------------------------------- 94
G + AG++E+VG+ + K GD V
Sbjct: 65 LGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMP 124
Query: 95 --TSSTISGG-----------YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALI 141
TS G ++EY + AD +V K+ + +G T Y A +
Sbjct: 125 DGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAV 184
Query: 142 HSACVKAGESVLVHGASGGVGLA---ACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVF 198
++A ++ G V G GGVGLA C++A A +I+G ++ + GA E
Sbjct: 185 NTAKLEPGSVCAVFGL-GGVGLAVIMGCKVAGA--SRIIGVDINKDKFARAKEFGATECI 241
Query: 199 NHREVNY-IDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGG 241
N ++ + I ++ + + G+D E + NV + + H G
Sbjct: 242 NPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKG 285
>gi|4501933 class I alcohol dehydrogenase, gamma subunit [Homo
sapiens]
Length = 375
Score = 57.4 bits (137), Expect = 2e-08
Identities = 65/284 (22%), Positives = 114/284 (40%), Gaps = 57/284 (20%)
Query: 27 DIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASA 86
++ V PK H+V IK+ A G+ + ++ SG LP G + AG++E+VG+ +
Sbjct: 26 EVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLVTP--LPVILGHEAAGIVESVGEGVTT 83
Query: 87 FKKGDRV---FTSS----------------------------------TISG-------- 101
K GD+V FT T SG
Sbjct: 84 VKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVG 143
Query: 102 --GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASG 159
+++Y + ++ V K+ ++ IG + T Y + + A V G + V G G
Sbjct: 144 VSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGL-G 202
Query: 160 GVGLAACQIARAYG-LKILGTAGTEEGQKIVLQNGAHEVFNHREVNY-IDKIKKYVGEKG 217
GVGL+ +A G +I+ ++ + GA E N ++ I ++ K + + G
Sbjct: 203 GVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGG 262
Query: 218 IDIIIEMLANVNLSKDLSLLSHG--GRVIVVG---SRGTIEINP 256
+D E++ ++ L H G ++VG + INP
Sbjct: 263 VDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINP 306
>gi|156523966 class V alcohol dehydrogenase isoform 1 [Homo sapiens]
Length = 375
Score = 57.0 bits (136), Expect = 2e-08
Identities = 66/277 (23%), Positives = 117/277 (42%), Gaps = 54/277 (19%)
Query: 3 TGQKLM-RAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSR 61
TGQ + +A +++ G P ++ ++ V PK +V IKV A G+ E + G+
Sbjct: 4 TGQVIRCKAAILWKPGAPFSIE---EVEVAPPKAKEVRIKVVATGLCGTEMKVL-GSKHL 59
Query: 62 KPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFT-------------------------- 95
L P G + AG++E++G+ S K GD+V T
Sbjct: 60 DLLYPTILGHEGAGIVESIGEGVSTVKPGDKVITLFLPQCGECTSCLNSEGNFCIQFKQS 119
Query: 96 -SSTISGG-------------------YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFT 135
+ +S G + EY + + +V K+ ++ I + T
Sbjct: 120 KTQLMSDGTSRFTCKGKSIYHFGNTSTFCEYTVIKEISVAKIDAVAPLEKVCLISCGFST 179
Query: 136 AYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYG-LKILGTAGTEEGQKIVLQNGA 194
+ A I++A V G + V G GGVGL+ +A G +I+G +E K + GA
Sbjct: 180 GFGAAINTAKVTPGSTCAVFGL-GGVGLSVVMGCKAAGAARIIGVDVNKEKFKKAQELGA 238
Query: 195 HEVFNHREVNY-IDKIKKYVGEKGIDIIIEMLANVNL 230
E N +++ I ++ + + GID E + N+++
Sbjct: 239 TECLNPQDLKKPIQEVLFDMTDAGIDFCFEAIGNLDV 275
>gi|4501939 class V alcohol dehydrogenase isoform 2 [Homo sapiens]
Length = 368
Score = 57.0 bits (136), Expect = 2e-08
Identities = 66/277 (23%), Positives = 117/277 (42%), Gaps = 54/277 (19%)
Query: 3 TGQKLM-RAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSR 61
TGQ + +A +++ G P ++ ++ V PK +V IKV A G+ E + G+
Sbjct: 4 TGQVIRCKAAILWKPGAPFSIE---EVEVAPPKAKEVRIKVVATGLCGTEMKVL-GSKHL 59
Query: 62 KPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFT-------------------------- 95
L P G + AG++E++G+ S K GD+V T
Sbjct: 60 DLLYPTILGHEGAGIVESIGEGVSTVKPGDKVITLFLPQCGECTSCLNSEGNFCIQFKQS 119
Query: 96 -SSTISGG-------------------YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFT 135
+ +S G + EY + + +V K+ ++ I + T
Sbjct: 120 KTQLMSDGTSRFTCKGKSIYHFGNTSTFCEYTVIKEISVAKIDAVAPLEKVCLISCGFST 179
Query: 136 AYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYG-LKILGTAGTEEGQKIVLQNGA 194
+ A I++A V G + V G GGVGL+ +A G +I+G +E K + GA
Sbjct: 180 GFGAAINTAKVTPGSTCAVFGL-GGVGLSVVMGCKAAGAARIIGVDVNKEKFKKAQELGA 238
Query: 195 HEVFNHREVNY-IDKIKKYVGEKGIDIIIEMLANVNL 230
E N +++ I ++ + + GID E + N+++
Sbjct: 239 TECLNPQDLKKPIQEVLFDMTDAGIDFCFEAIGNLDV 275
>gi|71743840 class IV alcohol dehydrogenase, mu or sigma subunit
[Homo sapiens]
Length = 386
Score = 52.0 bits (123), Expect = 7e-07
Identities = 57/271 (21%), Positives = 107/271 (39%), Gaps = 53/271 (19%)
Query: 27 DIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASA 86
+I V PK +V IK+ A G+ + ++ GT K P G + G++E++G+ +
Sbjct: 38 EIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVSK--FPVIVGHEATGIVESIGEGVTT 95
Query: 87 FKKGDRVF---------------------TSSTISG------------------------ 101
K GD+V S I+G
Sbjct: 96 VKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLADGTTRFTCKGKPVHHFMNT 155
Query: 102 -GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGG 160
+ EY + + +V K+ + ++ IG + T Y A + + VK G + +V G GG
Sbjct: 156 STFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGL-GG 214
Query: 161 VGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEVFNHRE-VNYIDKIKKYVGEKGI 218
VGL+ ++ G +I+G ++ + + GA E + ++ I ++ + +
Sbjct: 215 VGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECISPKDSTKPISEVLSEMTGNNV 274
Query: 219 DIIIEMLANVNLSKDLSLLSH--GGRVIVVG 247
E++ ++ D H G +VVG
Sbjct: 275 GYTFEVIGHLETMIDALASCHMNYGTSVVVG 305
>gi|71565152 class II alcohol dehydrogenase, pi subunit [Homo
sapiens]
Length = 380
Score = 42.4 bits (98), Expect = 6e-04
Identities = 67/322 (20%), Positives = 120/322 (37%), Gaps = 71/322 (22%)
Query: 9 RAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYT 68
+A +E G P ++ ++ V PK H+V I++ A + + + + P
Sbjct: 11 KAAIAWEAGKPLCIE---EVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEGLAF-PVI 66
Query: 69 PGSDVAGVIEAVGDNASAFKKGDRVF---------------------------------- 94
G + AG++E++G + K GD+V
Sbjct: 67 VGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLKSPASDQ 126
Query: 95 ------TSSTISGGYAEY-----------ALAADHTVYKLPEKLDFKQGAAIGIPYFTAY 137
TS G Y + +D + K+ + + ++ +G + T Y
Sbjct: 127 QLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGY 186
Query: 138 RALIHSACVKAGESVLVHGASGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHE 196
A I++A V G + V G GGVGL+A +A G +I+G E GA +
Sbjct: 187 GAAINNAKVTPGSTCAVFGL-GGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATD 245
Query: 197 VFNHREVNY-IDKIKKYVGEKGIDIIIEMLANVNLSK---DLSLLSHGGRV---IVVGSR 249
N R+++ I ++ + + G+D ++ K D + G + GS+
Sbjct: 246 CLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGVAAGSK 305
Query: 250 GTIEINPRDTMAKESSIIGVTL 271
G T+ E IIG T+
Sbjct: 306 GL-------TIFPEELIIGRTI 320
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 34.7 bits (78), Expect = 0.12
Identities = 35/107 (32%), Positives = 50/107 (46%), Gaps = 17/107 (15%)
Query: 129 IGIPYFTAYRALIHSACVK-----AGESVLVHGASGGVG-LAACQIARAYGLKIL---GT 179
+G F+ A+I + K AGE VL+ GA G+G L A Q AR + +L
Sbjct: 15 LGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINK 74
Query: 180 AGTEEGQKIVLQNGAHEVF------NHREVNY--IDKIKKYVGEKGI 218
G EE K+ + GA V + +E Y D++KK VG+ I
Sbjct: 75 EGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSI 121
>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
Length = 260
Score = 31.2 bits (69), Expect = 1.3
Identities = 15/30 (50%), Positives = 19/30 (63%)
Query: 153 LVHGASGGVGLAACQIARAYGLKILGTAGT 182
LV GASGG+G A + GLK++G A T
Sbjct: 15 LVTGASGGIGAAVARALVQQGLKVVGCART 44
>gi|40538880 aquaporin 12A [Homo sapiens]
Length = 295
Score = 29.6 bits (65), Expect = 3.9
Identities = 26/108 (24%), Positives = 50/108 (46%), Gaps = 12/108 (11%)
Query: 187 KIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVV 246
K +L GA+EVF + + ++ + G+ G D+++ +L L L+HG V +
Sbjct: 26 KALLPVGAYEVFAREAMRTLVELGPWAGDFGPDLLLTLLF-------LLFLAHG--VTLD 76
Query: 247 GSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGW 294
G+ ++ ++ + E S+ G L + + Q A L M + W
Sbjct: 77 GASANPTVSLQEFLMAEQSLPGTLLKLAAQGLGMQAACTL---MRLCW 121
>gi|10863929 ribonuclease L [Homo sapiens]
Length = 741
Score = 28.5 bits (62), Expect = 8.6
Identities = 33/115 (28%), Positives = 46/115 (40%), Gaps = 26/115 (22%)
Query: 162 GLAACQIARAYG----LKILGTAG--------TEEGQKIVLQNGAHEVFNHREVNYIDKI 209
G A A YG LK L G T+E Q+ + + GA + + E +++ +
Sbjct: 125 GFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVL 184
Query: 210 KKYVGEKGIDIII------EMLANVNLSKDLS--------LLSHGGRVIVVGSRG 250
K + E G D+ L + LS D S LL HG V V G RG
Sbjct: 185 KILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERG 239
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,559,283
Number of Sequences: 37866
Number of extensions: 484932
Number of successful extensions: 928
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 879
Number of HSP's gapped (non-prelim): 36
length of query: 329
length of database: 18,247,518
effective HSP length: 103
effective length of query: 226
effective length of database: 14,347,320
effective search space: 3242494320
effective search space used: 3242494320
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.