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Search of human proteins with 4557389
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557389 complement component 8, alpha polypeptide precursor
[Homo sapiens]
(584 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557389 complement component 8, alpha polypeptide precursor [... 1226 0.0
gi|4557391 complement component 8, beta polypeptide preproprotei... 340 2e-93
gi|189242612 complement component 6 precursor [Homo sapiens] 307 2e-83
gi|169636415 complement component 6 precursor [Homo sapiens] 307 2e-83
gi|45580688 complement component 7 precursor [Homo sapiens] 274 2e-73
gi|4502511 complement component 9 precursor [Homo sapiens] 261 2e-69
gi|133908621 perforin 1 precursor [Homo sapiens] 67 6e-11
gi|40254808 perforin 1 precursor [Homo sapiens] 67 6e-11
gi|16933525 unc5C [Homo sapiens] 62 1e-09
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 62 1e-09
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 62 1e-09
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 62 2e-09
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 61 3e-09
gi|40317628 thrombospondin 2 precursor [Homo sapiens] 59 9e-09
gi|118572606 hemicentin 1 [Homo sapiens] 58 3e-08
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 58 3e-08
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 57 4e-08
gi|209977117 unc-5 homolog D [Homo sapiens] 57 5e-08
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 57 6e-08
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 57 6e-08
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 57 6e-08
gi|32261318 unc-5 homolog B [Homo sapiens] 57 6e-08
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 57 6e-08
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 57 6e-08
gi|62243567 netrin receptor Unc5h1 [Homo sapiens] 57 6e-08
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 56 8e-08
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 56 8e-08
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 56 8e-08
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 56 8e-08
gi|40317626 thrombospondin 1 precursor [Homo sapiens] 55 1e-07
>gi|4557389 complement component 8, alpha polypeptide precursor
[Homo sapiens]
Length = 584
Score = 1226 bits (3173), Expect = 0.0
Identities = 584/584 (100%), Positives = 584/584 (100%)
Query: 1 MFAVVFFILSLMTCQPGVTAQEKVNQRVRRAATPAAVTCQLSNWSEWTDCFPCQDKKYRH 60
MFAVVFFILSLMTCQPGVTAQEKVNQRVRRAATPAAVTCQLSNWSEWTDCFPCQDKKYRH
Sbjct: 1 MFAVVFFILSLMTCQPGVTAQEKVNQRVRRAATPAAVTCQLSNWSEWTDCFPCQDKKYRH 60
Query: 61 RSLLQPNKFGGTICSGDIWDQASCSSSTTCVRQAQCGQDFQCKETGRCLKRHLVCNGDQD 120
RSLLQPNKFGGTICSGDIWDQASCSSSTTCVRQAQCGQDFQCKETGRCLKRHLVCNGDQD
Sbjct: 61 RSLLQPNKFGGTICSGDIWDQASCSSSTTCVRQAQCGQDFQCKETGRCLKRHLVCNGDQD 120
Query: 121 CLDGSDEDDCEDVRAIDEDCSQYEPIPGSQKAALGYNILTQEDAQSVYDASYYGGQCETV 180
CLDGSDEDDCEDVRAIDEDCSQYEPIPGSQKAALGYNILTQEDAQSVYDASYYGGQCETV
Sbjct: 121 CLDGSDEDDCEDVRAIDEDCSQYEPIPGSQKAALGYNILTQEDAQSVYDASYYGGQCETV 180
Query: 181 YNGEWRELRYDSTCERLYYGDDEKYFRKPYNFLKYHFEALADTGISSEFYDNANDLLSKV 240
YNGEWRELRYDSTCERLYYGDDEKYFRKPYNFLKYHFEALADTGISSEFYDNANDLLSKV
Sbjct: 181 YNGEWRELRYDSTCERLYYGDDEKYFRKPYNFLKYHFEALADTGISSEFYDNANDLLSKV 240
Query: 241 KKDKSDSFGVTIGIGPAGSPLLVGVGVSHSQDTSFLNELNKYNEKKFIFTRIFTKVQTAH 300
KKDKSDSFGVTIGIGPAGSPLLVGVGVSHSQDTSFLNELNKYNEKKFIFTRIFTKVQTAH
Sbjct: 241 KKDKSDSFGVTIGIGPAGSPLLVGVGVSHSQDTSFLNELNKYNEKKFIFTRIFTKVQTAH 300
Query: 301 FKMRKDDIMLDEGMLQSLMELPDQYNYGMYAKFINDYGTHYITSGSMGGIYEYILVIDKA 360
FKMRKDDIMLDEGMLQSLMELPDQYNYGMYAKFINDYGTHYITSGSMGGIYEYILVIDKA
Sbjct: 301 FKMRKDDIMLDEGMLQSLMELPDQYNYGMYAKFINDYGTHYITSGSMGGIYEYILVIDKA 360
Query: 361 KMESLGITSRDITTCFGGSLGIQYEDKINVGGGLSGDHCKKFGGGKTERARKAMAVEDII 420
KMESLGITSRDITTCFGGSLGIQYEDKINVGGGLSGDHCKKFGGGKTERARKAMAVEDII
Sbjct: 361 KMESLGITSRDITTCFGGSLGIQYEDKINVGGGLSGDHCKKFGGGKTERARKAMAVEDII 420
Query: 421 SRVRGGSSGWSGGLAQNRSTITYRSWGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKR 480
SRVRGGSSGWSGGLAQNRSTITYRSWGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKR
Sbjct: 421 SRVRGGSSGWSGGLAQNRSTITYRSWGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKR 480
Query: 481 QNLRRALDQYLMEFNACRCGPCFNNGVPILEGTSCRCQCRLGSLGAACEQTQTEGAKADG 540
QNLRRALDQYLMEFNACRCGPCFNNGVPILEGTSCRCQCRLGSLGAACEQTQTEGAKADG
Sbjct: 481 QNLRRALDQYLMEFNACRCGPCFNNGVPILEGTSCRCQCRLGSLGAACEQTQTEGAKADG 540
Query: 541 SWSCWSSWSVCRAGIQERRRECDNPAPQNGGASCPGRKVQTQAC 584
SWSCWSSWSVCRAGIQERRRECDNPAPQNGGASCPGRKVQTQAC
Sbjct: 541 SWSCWSSWSVCRAGIQERRRECDNPAPQNGGASCPGRKVQTQAC 584
>gi|4557391 complement component 8, beta polypeptide preproprotein
[Homo sapiens]
Length = 591
Score = 340 bits (872), Expect = 2e-93
Identities = 184/559 (32%), Positives = 286/559 (51%), Gaps = 42/559 (7%)
Query: 37 VTCQLSNWSEWTDCFPCQDKKYRHRSLLQPNKFGGTICSGDIWDQASCSSSTTCVRQAQC 96
+ C+LS+WS WT C PCQ K+YR+ LLQP++F G C+ + C ++ C Q +C
Sbjct: 63 IDCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCNFSDKEVEDCVTNRPCGSQVRC 122
Query: 97 GQDFQCKETGRCLKRHLVCNGDQDCLDGSDEDDCEDV-RAIDEDCSQYEPIPGSQKAALG 155
+ F C +TGRC+ R L+CNGD DC D SDE +C + + + QY G A G
Sbjct: 123 -EGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKCQHEMDQYW---GIGSLASG 178
Query: 156 YNILTQEDAQSVYDASYYGGQCETVYNGEWRELRYDSTCERLYYGDDEKYFRKPYNFLKY 215
N+ T V D YY G C Y R FRKPYN Y
Sbjct: 179 INLFTNSFEGPVLDHRYYAGGCSPHYILNTR-------------------FRKPYNVESY 219
Query: 216 HFEALADTGISSEFYDNANDLLSKVKKDKSDSFGVTIGIGPAGSPLLVGVGVSHSQDTS- 274
+ + Y++ +D V + + G + G G + +G+S D
Sbjct: 220 TPQTQGKYEFILKEYESYSDFERNVTEKMASKSGFSFGFKIPG---IFELGISSQSDRGK 276
Query: 275 -FLNELNKYNEKKFIFTRIFTKVQTAHFKMRKDDIMLDEGMLQSLMELPDQYNYGMYAKF 333
++ +++ K +F + ++ AH+K++ +ML LQ + LP +Y+YG Y
Sbjct: 277 HYIRRTKRFSHTKSVFLHARSDLEVAHYKLKPRSLMLHYEFLQRVKRLPLEYSYGEYRDL 336
Query: 334 INDYGTHYITSGSMGGIYEYILVIDKAKMESLGITSRDITTC------FGGSLGIQYEDK 387
D+GTHYIT +GGIYEY LV++K ME T ++ C GG++ ++
Sbjct: 337 FRDFGTHYITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHACAKNDFKIGGAI-----EE 391
Query: 388 INVGGGLSGDHCKKFGGGKTERARKAMAVEDIISRVRGGSSGWSGGLAQNR--STITYRS 445
+ V G+S C+ +R ++ VED++ VRGG+S LA + +
Sbjct: 392 VYVSLGVSVGKCRGILNEIKDRNKRDTMVEDLVVLVRGGASEHITTLAYQELPTADLMQE 451
Query: 446 WGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALDQYLMEFNACRCGPCFNN 505
WG +++YNP +I +++P++E++ T RQN+++AL+++ E ++C C PC N
Sbjct: 452 WGDAVQYNPAIIKVKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCHCAPCQGN 511
Query: 506 GVPILEGTSCRCQCRLGSLGAACEQTQTEGAKADGSWSCWSSWSVCRAGIQERRRECDNP 565
GVP+L+G+ C C C +GS G ACE + + DG W+CWS+WS C + R+R+C+NP
Sbjct: 512 GVPVLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCSGRRKTRQRQCNNP 571
Query: 566 APQNGGASCPGRKVQTQAC 584
PQNGG+ C G +T C
Sbjct: 572 PPQNGGSPCSGPASETLDC 590
>gi|189242612 complement component 6 precursor [Homo sapiens]
Length = 934
Score = 307 bits (787), Expect = 2e-83
Identities = 183/566 (32%), Positives = 281/566 (49%), Gaps = 52/566 (9%)
Query: 37 VTCQLSNWSEWTDCFPCQDKKYRHRSLLQPNKFGGTICSGDIWDQASCSSSTTC-VRQAQ 95
+ C L ++ W+DC PC +K+ + RS+L+P++FGG C+ + C S C + +A
Sbjct: 80 INCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCKIEEAD 139
Query: 96 CGQDFQCKETGRCLKRHLVCNGDQDCLDGSDEDDCEDVRAIDEDCSQ-YEPIPGSQKAAL 154
C F+C ++GRC+ R L CNG+ DC D SDE DC +A+ C++ Y PIP Q
Sbjct: 140 CKNKFRC-DSGRCIARKLECNGENDCGDNSDERDCGRTKAV---CTRKYNPIPSVQLMGN 195
Query: 155 GYNILTQEDAQSVYDASYYGGQCETVYNGEWRELRYDSTCERLYYGDDEKYFRKPYNFLK 214
G++ L E V D S+ GG C+TV + +R P N
Sbjct: 196 GFHFLAGEPRGEVLDNSFTGGICKTVKSSR-----------------TSNPYRVPANLEN 238
Query: 215 YHFEA-LADTGISSEFYDNANDLLSKVKKDKS------DSFGVTIGIGPAGSPLLVGVGV 267
FE A+ + ++FY + L + S SF V I S +
Sbjct: 239 VGFEVQTAEDDLKTDFYKDLTSLGHNENQQGSFSSQGGSSFSVPIFYSSKRSE-----NI 293
Query: 268 SHSQDTSFLNELNKYNEKKFIFTRIFTKVQTAHFKMRKDDIMLDEGMLQSLMELPDQYNY 327
+H+ ++F + ++K F RI ++ +F + D+ L + L++L LP +YN
Sbjct: 294 NHN--SAFKQAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNS 351
Query: 328 GMYAKFINDYGTHYITSGSMGGIYEYILVIDKAKMESLGITSRDITTCFGGSLGIQYEDK 387
+Y++ +D+GTHY TSGS+GG+Y+ + ++++ G+T + C + I+ + +
Sbjct: 352 ALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHC----VRIETKKR 407
Query: 388 INVGGGLSGDH-CKKFGGGKTERARKAMAVEDIISRVRGGSSGWSGGLAQNRSTI----- 441
+ +H C + E IS +RGG S + LA + +
Sbjct: 408 VLFAKKTKVEHRCTTNKLSEKHEGSFIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEK 467
Query: 442 TYRSWGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALDQYLMEFNACRCGP 501
T+ W S+K NP VIDFE+ PI +++R+ KR NLR+AL +Y +F+ C+C P
Sbjct: 468 TFSEWLESVKENPAVIDFELAPIVDLVRNIPCA--VTKRNNLRKALQEYAAKFDPCQCAP 525
Query: 502 CFNNGVPILEGTSCRCQCRLGSLGAACEQTQTE--GAKADGSWSCWSSWSVCRAGI-QER 558
C NNG P L GT C C C+ G+ G CE+ + DG W CWSSWS C A + R
Sbjct: 526 CPNNGRPTLSGTECLCVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSR 585
Query: 559 RRECDNPAPQNGGASCPGRKVQTQAC 584
REC+NPAPQ GG C G K Q + C
Sbjct: 586 TRECNNPAPQRGGKRCEGEKRQEEDC 611
>gi|169636415 complement component 6 precursor [Homo sapiens]
Length = 934
Score = 307 bits (787), Expect = 2e-83
Identities = 183/566 (32%), Positives = 281/566 (49%), Gaps = 52/566 (9%)
Query: 37 VTCQLSNWSEWTDCFPCQDKKYRHRSLLQPNKFGGTICSGDIWDQASCSSSTTC-VRQAQ 95
+ C L ++ W+DC PC +K+ + RS+L+P++FGG C+ + C S C + +A
Sbjct: 80 INCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCKIEEAD 139
Query: 96 CGQDFQCKETGRCLKRHLVCNGDQDCLDGSDEDDCEDVRAIDEDCSQ-YEPIPGSQKAAL 154
C F+C ++GRC+ R L CNG+ DC D SDE DC +A+ C++ Y PIP Q
Sbjct: 140 CKNKFRC-DSGRCIARKLECNGENDCGDNSDERDCGRTKAV---CTRKYNPIPSVQLMGN 195
Query: 155 GYNILTQEDAQSVYDASYYGGQCETVYNGEWRELRYDSTCERLYYGDDEKYFRKPYNFLK 214
G++ L E V D S+ GG C+TV + +R P N
Sbjct: 196 GFHFLAGEPRGEVLDNSFTGGICKTVKSSR-----------------TSNPYRVPANLEN 238
Query: 215 YHFEA-LADTGISSEFYDNANDLLSKVKKDKS------DSFGVTIGIGPAGSPLLVGVGV 267
FE A+ + ++FY + L + S SF V I S +
Sbjct: 239 VGFEVQTAEDDLKTDFYKDLTSLGHNENQQGSFSSQGGSSFSVPIFYSSKRSE-----NI 293
Query: 268 SHSQDTSFLNELNKYNEKKFIFTRIFTKVQTAHFKMRKDDIMLDEGMLQSLMELPDQYNY 327
+H+ ++F + ++K F RI ++ +F + D+ L + L++L LP +YN
Sbjct: 294 NHN--SAFKQAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNS 351
Query: 328 GMYAKFINDYGTHYITSGSMGGIYEYILVIDKAKMESLGITSRDITTCFGGSLGIQYEDK 387
+Y++ +D+GTHY TSGS+GG+Y+ + ++++ G+T + C + I+ + +
Sbjct: 352 ALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHC----VRIETKKR 407
Query: 388 INVGGGLSGDH-CKKFGGGKTERARKAMAVEDIISRVRGGSSGWSGGLAQNRSTI----- 441
+ +H C + E IS +RGG S + LA + +
Sbjct: 408 VLFAKKTKVEHRCTTNKLSEKHEGSFIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEK 467
Query: 442 TYRSWGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALDQYLMEFNACRCGP 501
T+ W S+K NP VIDFE+ PI +++R+ KR NLR+AL +Y +F+ C+C P
Sbjct: 468 TFSEWLESVKENPAVIDFELAPIVDLVRNIPCA--VTKRNNLRKALQEYAAKFDPCQCAP 525
Query: 502 CFNNGVPILEGTSCRCQCRLGSLGAACEQTQTE--GAKADGSWSCWSSWSVCRAGI-QER 558
C NNG P L GT C C C+ G+ G CE+ + DG W CWSSWS C A + R
Sbjct: 526 CPNNGRPTLSGTECLCVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSR 585
Query: 559 RRECDNPAPQNGGASCPGRKVQTQAC 584
REC+NPAPQ GG C G K Q + C
Sbjct: 586 TRECNNPAPQRGGKRCEGEKRQEEDC 611
>gi|45580688 complement component 7 precursor [Homo sapiens]
Length = 843
Score = 274 bits (700), Expect = 2e-73
Identities = 170/565 (30%), Positives = 264/565 (46%), Gaps = 50/565 (8%)
Query: 31 AATPAAVTCQLSNWSEWTDCFPCQDKKYRHRSLLQPNKFGGTICSGDIWDQASCSSSTTC 90
++ + V CQ ++ W++C C + R RS+ ++GG C G+ ++ SC + C
Sbjct: 20 SSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCEPTRGC 79
Query: 91 VRQAQCGQDFQCKETGRCLKRHLVCNGDQDC-LDGSDEDDCEDVRAIDEDCSQYEPIPGS 149
+ CG+ F+C +G+C+ + LVCNGD DC D +DED CED C +P P
Sbjct: 80 PTEEGCGERFRCF-SGQCISKSLVCNGDSDCDEDSADEDRCEDSER-RPSCDIDKPPPNI 137
Query: 150 QKAALGYNILTQEDAQSVYDASYYGGQCETVYNGEWRELRYDSTCERLYYGDDEKYFRKP 209
+ GYN LT + V + +GGQC V++G D + ++R
Sbjct: 138 ELTGNGYNELTGQFRNRVINTKSFGGQCRKVFSG-----------------DGKDFYRLS 180
Query: 210 YNFLKYHFEALADTGISSEFYDNANDLLSKVKKDKSDSFGVTIGIGPAGSPLLVGVGVSH 269
N L Y F+ + + EFY++ + + + S + S S
Sbjct: 181 GNVLSYTFQVKINNDFNYEFYNSTWSYVKHTSTEHTSSSRKRSFFRSSSS--------SS 232
Query: 270 SQDTSFLNELNKYNEKKFIFTRIFTKVQTAHFKMRKDDIM-LDEGMLQSLMELPDQYNYG 328
TS NE++K K + + V+ A F + + L E + L LP Y+Y
Sbjct: 233 RSYTSHTNEIHK--GKSYQLLVVENTVEVAQFINNNPEFLQLAEPFWKELSHLPSLYDYS 290
Query: 329 MYAKFINDYGTHYITSGSMGGIYEYILVIDKAKMESLGITSRDITTCFGGSLGIQYEDKI 388
Y + I+ YGTHY+ SGS+GG Y + +D K++ S + C S G + K
Sbjct: 291 AYRRLIDQYGTHYLQSGSLGGEYRVLFYVDSEKLKQNDFNSVEEKKC--KSSGWHFVVKF 348
Query: 389 NVGGGLSGDHCKKFGGGKTERARKAMAVEDIISRVRGGSSGWSGGLAQNR------STIT 442
+ G ++ K G + +RGG +G+ GL+ +
Sbjct: 349 SSHGCKELENALKAASGTQNNVLRGEPF------IRGGGAGFISGLSYLELDNPAGNKRR 402
Query: 443 YRSWGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALDQYLMEFNACRCGPC 502
Y +W S+ P VI ++ P++E+++ + K+ L+ AL++YL EF+ C C PC
Sbjct: 403 YSAWAESVTNLPQVIKQKLTPLYELVKEVPCASV--KKLYLKWALEEYLDEFDPCHCRPC 460
Query: 503 FNNGVPILEGTSCRCQCRLGSLGAACEQTQTEGAKA---DGSWSCWSSWSVCRAGIQERR 559
N G+ +EGT C C C+ + GAACEQ G +A DG WSCWSSWS C G + R
Sbjct: 461 QNGGLATVEGTHCLCHCKPYTFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCVQGKKTRS 520
Query: 560 RECDNPAPQNGGASCPGRKVQTQAC 584
REC+NP P GG SC G ++ C
Sbjct: 521 RECNNPPPSGGGRSCVGETTESTQC 545
>gi|4502511 complement component 9 precursor [Homo sapiens]
Length = 559
Score = 261 bits (666), Expect = 2e-69
Identities = 168/568 (29%), Positives = 269/568 (47%), Gaps = 53/568 (9%)
Query: 2 FAVVFFIL--SLMTCQPGVTAQEKVNQRVRRAATPAAVTCQLSNWSEWTDCFPCQDKKYR 59
FAV IL S++T Q + ++ + + + + + C++S WSEW+ C PC + +R
Sbjct: 7 FAVAICILEISILTAQYTTSYDPELTES---SGSASHIDCRMSPWSEWSQCDPCLRQMFR 63
Query: 60 HRSLLQPNKFGGTICSGDIWDQASCSSSTTCV-RQAQCGQDFQCKETGRCLKRHLVCNGD 118
RS+ +F G C+ + D+ C + C + CG DFQC TGRC+K L CNGD
Sbjct: 64 SRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDDCGNDFQCS-TGRCIKMRLRCNGD 122
Query: 119 QDCLDGSDEDDCEDVRAIDEDCSQYEPIPGSQKAALGYNILTQEDAQSVYDASYYGGQCE 178
DC D SDEDDCE E ++ A G NIL + + +D +Y G
Sbjct: 123 NDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNG--- 179
Query: 179 TVYNGEWRELRYDSTCERLYYGDDEKYFRKPYNFLKYHFEALADTGISSEFYDNANDLLS 238
C R G+ Y+R+P+N +E + +E Y+ +
Sbjct: 180 --------------LCNRDRDGNTLTYYRRPWNVASLIYETKGEKNFRTEHYEEQIEAFK 225
Query: 239 KVKKDKSDSFGVTIGIG---------------PAGSPLLVGVG---VSHSQDTSFLNELN 280
+ ++K+ +F I + A S L G G S+S++ ++ L+
Sbjct: 226 SIIQEKTSNFNAAISLKFTPTETNKAEQCCEETASSISLHGKGSFRFSYSKNETYQLFLS 285
Query: 281 KYNEKKFIFTRIFTKVQTAHFKMRKDDIMLDEGMLQSLMELPDQYNYGMYAKFINDYGTH 340
++K+ +F + ++ F MR D++L + + LP Y G Y F+ YGTH
Sbjct: 286 YSSKKEKMFLHVKGEIHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEYFAFLETYGTH 345
Query: 341 YITSGSMGGIYEYILVIDKAKMESLGITSRDITTCFGGSLGIQYE-DKINVGGGLSGDHC 399
Y +SGS+GG+YE I V+DKA M+ G+ +DI C G L + +I+VG + D C
Sbjct: 346 YSSSGSLGGLYELIYVLDKASMKRKGVELKDIKRCLGYHLDVSLAFSEISVGAEFNKDDC 405
Query: 400 KKFGGGKTERARKAMAVEDIISRVRGGSSGWSGGLAQN--RSTI----TYRSWGRSLKYN 453
K G G+ ++D++S +RGG+ ++ L + R T+ + +W S+
Sbjct: 406 VKRGEGRAVNITSENLIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTDFVNWASSINDA 465
Query: 454 PVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALDQYLMEFNACRCGPCFNNGVPILEGT 513
PV+I ++ PI+ ++ + K+QNL RA++ Y+ EF+ +C C N G IL
Sbjct: 466 PVLISQKLSPIYNLV-PVKMKNAHLKKQNLERAIEDYINEFSVRKCHTCQNGGTVILMDG 524
Query: 514 SCRCQCRLGSLGAACE---QTQTEGAKA 538
C C C G ACE Q +EG A
Sbjct: 525 KCLCACPFKFEGIACEISKQKISEGLPA 552
>gi|133908621 perforin 1 precursor [Homo sapiens]
Length = 555
Score = 66.6 bits (161), Expect = 6e-11
Identities = 68/305 (22%), Positives = 121/305 (39%), Gaps = 37/305 (12%)
Query: 263 VGVGVSHSQDTSFLNELNKYNEKKFIFTRIFTKVQTAHFKMRKDDIMLDEGMLQSLMELP 322
V V SHSQ +F + ++ F + + + H L ++L +LP
Sbjct: 145 VSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPP---LHPDFKRALGDLP 201
Query: 323 DQYNYGM---YAKFINDYGTHYITSGSMGGIYEYILVIDKAKMESLGITSRDITTCFGGS 379
+N Y + I++YGTH+I + +GG + + ++ G+T ++ C
Sbjct: 202 HHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDC---- 257
Query: 380 LGIQYEDKINVGGGLSGD----------HCKKFGGGKTERARKAMAVEDIISRVRGGSSG 429
L ++ + I + G +S + H +T R R + V + + G
Sbjct: 258 LTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFG 317
Query: 430 WSGGLAQNRSTITYRSWGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALDQ 489
G Q Y +W SL +P ++D+ ++P+H + L + +R+ LRRAL Q
Sbjct: 318 IQAGPEQ------YSAWVNSLPGSPGLVDYTLEPLHVL-----LDSQDPRREALRRALSQ 366
Query: 490 YLMEFNACR-CGPCFNNGVPILEGTSCRCQCRLGSLGAA-CEQTQTEGAKAD----GSWS 543
YL + R C G C+C C ++ C Q A+ + +W
Sbjct: 367 YLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWG 426
Query: 544 CWSSW 548
W W
Sbjct: 427 LWGDW 431
>gi|40254808 perforin 1 precursor [Homo sapiens]
Length = 555
Score = 66.6 bits (161), Expect = 6e-11
Identities = 68/305 (22%), Positives = 121/305 (39%), Gaps = 37/305 (12%)
Query: 263 VGVGVSHSQDTSFLNELNKYNEKKFIFTRIFTKVQTAHFKMRKDDIMLDEGMLQSLMELP 322
V V SHSQ +F + ++ F + + + H L ++L +LP
Sbjct: 145 VSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPP---LHPDFKRALGDLP 201
Query: 323 DQYNYGM---YAKFINDYGTHYITSGSMGGIYEYILVIDKAKMESLGITSRDITTCFGGS 379
+N Y + I++YGTH+I + +GG + + ++ G+T ++ C
Sbjct: 202 HHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDC---- 257
Query: 380 LGIQYEDKINVGGGLSGD----------HCKKFGGGKTERARKAMAVEDIISRVRGGSSG 429
L ++ + I + G +S + H +T R R + V + + G
Sbjct: 258 LTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFG 317
Query: 430 WSGGLAQNRSTITYRSWGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALDQ 489
G Q Y +W SL +P ++D+ ++P+H + L + +R+ LRRAL Q
Sbjct: 318 IQAGPEQ------YSAWVNSLPGSPGLVDYTLEPLHVL-----LDSQDPRREALRRALSQ 366
Query: 490 YLMEFNACR-CGPCFNNGVPILEGTSCRCQCRLGSLGAA-CEQTQTEGAKAD----GSWS 543
YL + R C G C+C C ++ C Q A+ + +W
Sbjct: 367 YLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWG 426
Query: 544 CWSSW 548
W W
Sbjct: 427 LWGDW 431
>gi|16933525 unc5C [Homo sapiens]
Length = 931
Score = 62.4 bits (150), Expect = 1e-09
Identities = 29/58 (50%), Positives = 34/58 (58%), Gaps = 4/58 (6%)
Query: 531 TQTEGAKADGSWSCWSSWSVCRA----GIQERRRECDNPAPQNGGASCPGRKVQTQAC 584
T T +G WS W+ WSVC + G Q+R R C NPAP NGGA C G+ VQ AC
Sbjct: 252 TATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIAC 309
Score = 54.7 bits (130), Expect = 2e-07
Identities = 36/102 (35%), Positives = 45/102 (44%), Gaps = 17/102 (16%)
Query: 493 EFNAC--RCGPCFN-------NGVPILEGTSCRCQCRLGSLGAACEQTQTEGAKADGSWS 543
E++ C RCG + N P+ G C Q AC T DG W+
Sbjct: 268 EWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQ---SVQKIAC----TTLCPVDGRWT 320
Query: 544 CWSSWSVCRAGIQE-RRRECDNPAPQNGGASCPGRKVQTQAC 584
WS WS C RRREC PAP+NGG C G +Q++ C
Sbjct: 321 PWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNC 362
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
motif, 17 preproprotein [Homo sapiens]
Length = 1095
Score = 62.4 bits (150), Expect = 1e-09
Identities = 32/83 (38%), Positives = 39/83 (46%), Gaps = 10/83 (12%)
Query: 508 PILEGTSCRCQ--CRLGSLGAACEQTQTEGAKADGSWSCWSSWSVCR----AGIQERRRE 561
P L+GT C CR G C DG WS W +WS+C G + R+R+
Sbjct: 514 PPLDGTECGADKWCRAGE----CVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRK 569
Query: 562 CDNPAPQNGGASCPGRKVQTQAC 584
CDNP P GG CPG V+ C
Sbjct: 570 CDNPPPGPGGTHCPGASVEHAVC 592
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 62.4 bits (150), Expect = 1e-09
Identities = 33/87 (37%), Positives = 44/87 (50%), Gaps = 7/87 (8%)
Query: 504 NNGVPILEGTSCRCQCRLGSLGAACEQTQTEGAK--ADGSWSCWSSWS----VCRAGIQE 557
N +P +GT C L S G+ + + E K ADG W+ W W C G+Q
Sbjct: 490 NGSLPWADGTPCG-PGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQF 548
Query: 558 RRRECDNPAPQNGGASCPGRKVQTQAC 584
REC +P PQNGG C GR+ + Q+C
Sbjct: 549 SHRECKDPEPQNGGRYCLGRRAKYQSC 575
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 61.6 bits (148), Expect = 2e-09
Identities = 31/89 (34%), Positives = 43/89 (48%), Gaps = 10/89 (11%)
Query: 502 CFNNGVPILEGTSCR--CQCRLGSLGAACEQTQTEGAKADGSWSCWSSWS----VCRAGI 555
CF VP +GT C CR G C +TE +G W W +S C GI
Sbjct: 521 CFTQHVPPADGTDCGPGMHCRHG----LCVNKETETRPVNGEWGPWEPYSSCSRTCGGGI 576
Query: 556 QERRRECDNPAPQNGGASCPGRKVQTQAC 584
+ R C+ P P+NGG C GR+++ ++C
Sbjct: 577 ESATRRCNRPEPRNGGNYCVGRRMKFRSC 605
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 60.8 bits (146), Expect = 3e-09
Identities = 31/87 (35%), Positives = 44/87 (50%), Gaps = 5/87 (5%)
Query: 502 CFNNGVPILEGTSCRCQCRLGSLGAACEQTQTEGAKADGSWSCWSSWS----VCRAGIQE 557
C P +GTSC + +L GA E+ + DGSW+ W + C G+Q
Sbjct: 480 CQTRHFPWADGTSCG-EGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQL 538
Query: 558 RRRECDNPAPQNGGASCPGRKVQTQAC 584
RR+C NP P NGG C G +V+ ++C
Sbjct: 539 ARRQCTNPTPANGGKYCEGVRVKYRSC 565
>gi|40317628 thrombospondin 2 precursor [Homo sapiens]
Length = 1172
Score = 59.3 bits (142), Expect = 9e-09
Identities = 33/87 (37%), Positives = 44/87 (50%), Gaps = 14/87 (16%)
Query: 504 NNGVPILEGTSCRCQCRLGSLGAACEQTQTEGAKA--DGSWSCWSSWSVCRA----GIQE 557
N+ VP + G +C+ G+ E +GA DG WS WS WS C GI+E
Sbjct: 465 NSPVPQMGGKNCK--------GSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRE 516
Query: 558 RRRECDNPAPQNGGASCPGRKVQTQAC 584
R R C++P PQ GG +C G + Q C
Sbjct: 517 RTRVCNSPEPQYGGKACVGDVQERQMC 543
Score = 51.6 bits (122), Expect = 2e-06
Identities = 34/101 (33%), Positives = 43/101 (42%), Gaps = 24/101 (23%)
Query: 508 PILEGTSCRCQCRLGSL--GAACEQT---------QTEGA---------KADGSWSCWSS 547
P E T C C G+ G +C+ T QT + DG WS WS
Sbjct: 386 PWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSP 445
Query: 548 WS----VCRAGIQERRRECDNPAPQNGGASCPGRKVQTQAC 584
WS C G R R C++P PQ GG +C G +T+AC
Sbjct: 446 WSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKAC 486
Score = 35.8 bits (81), Expect = 0.11
Identities = 17/47 (36%), Positives = 25/47 (53%), Gaps = 9/47 (19%)
Query: 542 WSCWSSWS----VCRAGIQERRRECDNPAPQNGGASCPGRKVQTQAC 584
WS W+ W+ C +G Q+R R CD + +C G +QT+AC
Sbjct: 384 WSPWAEWTQCSVTCGSGTQQRGRSCDVTS-----NTCLGPSIQTRAC 425
Score = 30.0 bits (66), Expect = 6.1
Identities = 19/75 (25%), Positives = 31/75 (41%), Gaps = 12/75 (16%)
Query: 34 PAAVTCQLSNWSEWTDCFPCQDKKYRHRSLLQPN---KFGGTICSGDIWDQASCSS---- 86
P + + S WS W+ C R R+ + + ++GG C GD+ ++ C+
Sbjct: 490 PCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCP 549
Query: 87 -----STTCVRQAQC 96
S C AQC
Sbjct: 550 VDGCLSNPCFPGAQC 564
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 57.8 bits (138), Expect = 3e-08
Identities = 30/85 (35%), Positives = 39/85 (45%), Gaps = 10/85 (11%)
Query: 504 NNGVPILEGTSCRCQCRLGSLGAACEQTQTEGAKADGSWSCWSSWSVCRA----GIQERR 559
+N P G +C G + ++ T+ DGSW W SWS C A G + R+
Sbjct: 4785 DNPPPSNGGRAC------GGPDSQIQRCNTDMCPVDGSWGSWHSWSQCSASCGGGEKTRK 4838
Query: 560 RECDNPAPQNGGASCPGRKVQTQAC 584
R CD+P P GG CPG Q C
Sbjct: 4839 RLCDHPVPVKGGRPCPGDTTQVTRC 4863
Score = 53.5 bits (127), Expect = 5e-07
Identities = 28/71 (39%), Positives = 33/71 (46%), Gaps = 11/71 (15%)
Query: 525 GAACE--QTQTEGAKAD-----GSWSCWSSWSVC----RAGIQERRRECDNPAPQNGGAS 573
G CE Q++ +D G+WS WS W C G R R CDNP P NGG +
Sbjct: 4736 GRKCEGSDVQSDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRA 4795
Query: 574 CPGRKVQTQAC 584
C G Q Q C
Sbjct: 4796 CGGPDSQIQRC 4806
Score = 52.8 bits (125), Expect = 9e-07
Identities = 24/71 (33%), Positives = 34/71 (47%), Gaps = 11/71 (15%)
Query: 525 GAACEQTQTE-------GAKADGSWSCWSSWSVCRA----GIQERRRECDNPAPQNGGAS 573
G+ C+ +T+ G W+ W+SWS C G ++R R C +P PQ GG
Sbjct: 4679 GSYCDGAETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRK 4738
Query: 574 CPGRKVQTQAC 584
C G VQ+ C
Sbjct: 4739 CEGSDVQSDFC 4749
Score = 50.8 bits (120), Expect = 3e-06
Identities = 24/57 (42%), Positives = 29/57 (50%), Gaps = 4/57 (7%)
Query: 532 QTEGAKADGSWSCWSSWSVCRA----GIQERRRECDNPAPQNGGASCPGRKVQTQAC 584
Q + DGSWS WS W C G Q R R C+NP+ Q+GG C G V+ C
Sbjct: 4579 QNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMC 4635
Score = 50.1 bits (118), Expect = 6e-06
Identities = 21/49 (42%), Positives = 25/49 (51%), Gaps = 4/49 (8%)
Query: 540 GSWSCWSSWSVCRA----GIQERRRECDNPAPQNGGASCPGRKVQTQAC 584
G+WS W W C G Q R R C+NP P GG+ C G + Q Q C
Sbjct: 4644 GAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVC 4692
Score = 46.6 bits (109), Expect = 6e-05
Identities = 20/49 (40%), Positives = 27/49 (55%), Gaps = 4/49 (8%)
Query: 540 GSWSCWSSWSVCRA----GIQERRRECDNPAPQNGGASCPGRKVQTQAC 584
G +S WS+W C GIQ+R R C+ P P NGG C G ++ + C
Sbjct: 4530 GGFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNC 4578
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 57.8 bits (138), Expect = 3e-08
Identities = 28/89 (31%), Positives = 45/89 (50%), Gaps = 7/89 (7%)
Query: 502 CFNNGVPILEGTSCRCQCRLGSLGAACEQTQTE--GAKADGSWSCWSSWSVCR----AGI 555
C +P +EGT C + R+ G ++T+ + + G+W W SW C G+
Sbjct: 529 CLTKKLPAVEGTPCG-KGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGV 587
Query: 556 QERRRECDNPAPQNGGASCPGRKVQTQAC 584
Q R C+NPAP+N G C G++ ++C
Sbjct: 588 QFAYRHCNNPAPRNNGRYCTGKRAIYRSC 616
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 57.4 bits (137), Expect = 4e-08
Identities = 30/89 (33%), Positives = 42/89 (47%), Gaps = 7/89 (7%)
Query: 502 CFNNGVPILEGTSCRCQCRLGSLGAACEQTQTE--GAKADGSWSCWSSWS----VCRAGI 555
C P +GTSC + + G +T + GSW W W C G+
Sbjct: 521 CQTKHFPWADGTSCG-EGKWCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGV 579
Query: 556 QERRRECDNPAPQNGGASCPGRKVQTQAC 584
Q RECDNP P+NGG C G++V+ ++C
Sbjct: 580 QYTMRECDNPVPKNGGKYCEGKRVRYRSC 608
>gi|209977117 unc-5 homolog D [Homo sapiens]
Length = 953
Score = 57.0 bits (136), Expect = 5e-08
Identities = 25/50 (50%), Positives = 28/50 (56%), Gaps = 4/50 (8%)
Query: 539 DGSWSCWSSWSVCRA----GIQERRRECDNPAPQNGGASCPGRKVQTQAC 584
+G WS W+ WS C G Q+R R C NPAP NGGA C G VQ C
Sbjct: 252 NGGWSSWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKITC 301
Score = 55.8 bits (133), Expect = 1e-07
Identities = 41/123 (33%), Positives = 54/123 (43%), Gaps = 22/123 (17%)
Query: 478 AKRQNLRRALDQYL-------MEFNAC--RCGPCFNNGVPILEGTSCRCQCRLGSLGAAC 528
AKR++L + Y+ E++AC RCG + +C L GA C
Sbjct: 238 AKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQK-----RSRTCTNPAPLNG-GAFC 291
Query: 529 EQ------TQTEGAKADGSWSCWSSWSVCRAGIQERR-RECDNPAPQNGGASCPGRKVQT 581
E T T DGSW WS WSVC + R REC P P+NGG C G ++
Sbjct: 292 EGMSVQKITCTSLCPVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQES 351
Query: 582 QAC 584
+ C
Sbjct: 352 ENC 354
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 56.6 bits (135), Expect = 6e-08
Identities = 31/84 (36%), Positives = 41/84 (48%), Gaps = 8/84 (9%)
Query: 507 VPILEGTSCRCQ--CRLGSLGAACEQTQTEGAKADGSWSCWSSWSVCR----AGIQERRR 560
VP+L+GT C + C G + E T A G WS W S C G+ RRR
Sbjct: 321 VPLLDGTECGVEKWCSKGRCRSLVELTPI--AAVHGRWSSWGPRSPCSRSCGGGVVTRRR 378
Query: 561 ECDNPAPQNGGASCPGRKVQTQAC 584
+C+NP P GG +C G +Q + C
Sbjct: 379 QCNNPRPAFGGRACVGADLQAEMC 402
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 56.6 bits (135), Expect = 6e-08
Identities = 31/84 (36%), Positives = 41/84 (48%), Gaps = 8/84 (9%)
Query: 507 VPILEGTSCRCQ--CRLGSLGAACEQTQTEGAKADGSWSCWSSWSVCR----AGIQERRR 560
VP+L+GT C + C G + E T A G WS W S C G+ RRR
Sbjct: 352 VPLLDGTECGVEKWCSKGRCRSLVELTPI--AAVHGRWSSWGPRSPCSRSCGGGVVTRRR 409
Query: 561 ECDNPAPQNGGASCPGRKVQTQAC 584
+C+NP P GG +C G +Q + C
Sbjct: 410 QCNNPRPAFGGRACVGADLQAEMC 433
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 56.6 bits (135), Expect = 6e-08
Identities = 31/84 (36%), Positives = 41/84 (48%), Gaps = 8/84 (9%)
Query: 507 VPILEGTSCRCQ--CRLGSLGAACEQTQTEGAKADGSWSCWSSWSVCR----AGIQERRR 560
VP+L+GT C + C G + E T A G WS W S C G+ RRR
Sbjct: 352 VPLLDGTECGVEKWCSKGRCRSLVELTPI--AAVHGRWSSWGPRSPCSRSCGGGVVTRRR 409
Query: 561 ECDNPAPQNGGASCPGRKVQTQAC 584
+C+NP P GG +C G +Q + C
Sbjct: 410 QCNNPRPAFGGRACVGADLQAEMC 433
>gi|32261318 unc-5 homolog B [Homo sapiens]
Length = 945
Score = 56.6 bits (135), Expect = 6e-08
Identities = 27/58 (46%), Positives = 31/58 (53%), Gaps = 4/58 (6%)
Query: 531 TQTEGAKADGSWSCWSSWSVCR----AGIQERRRECDNPAPQNGGASCPGRKVQTQAC 584
T T +G WS W+ WS C G Q+R R C NPAP NGGA C G+ Q AC
Sbjct: 238 TATVIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTAC 295
Score = 50.8 bits (120), Expect = 3e-06
Identities = 29/82 (35%), Positives = 37/82 (45%), Gaps = 10/82 (12%)
Query: 505 NGVPILEGTSCRCQCRLGSLGAACEQTQ-TEGAKADGSWSCWSSWSVCRAGIQE-RRREC 562
N P+ G C G A ++T T DG+W+ WS WS C R REC
Sbjct: 275 NPAPLNGGAFCE--------GQAFQKTACTTICPVDGAWTEWSKWSACSTECAHWRSREC 326
Query: 563 DNPAPQNGGASCPGRKVQTQAC 584
P PQNGG C G + ++ C
Sbjct: 327 MAPPPQNGGRDCSGTLLDSKNC 348
Score = 33.9 bits (76), Expect = 0.43
Identities = 16/64 (25%), Positives = 28/64 (43%), Gaps = 6/64 (9%)
Query: 29 RRAATPAAVTCQLSNWSEWTDCFPCQDK-----KYRHRSLLQPNKF-GGTICSGDIWDQA 82
RR+ T + WS W + PC ++ + R R+ P GG C G + +
Sbjct: 234 RRSTTATVIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKT 293
Query: 83 SCSS 86
+C++
Sbjct: 294 ACTT 297
Score = 29.6 bits (65), Expect = 8.0
Identities = 14/45 (31%), Positives = 22/45 (48%), Gaps = 3/45 (6%)
Query: 44 WSEWTDCFPCQDKKYRHRS---LLQPNKFGGTICSGDIWDQASCS 85
W+EW+ C + RS + P + GG CSG + D +C+
Sbjct: 305 WTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCT 349
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 56.6 bits (135), Expect = 6e-08
Identities = 33/90 (36%), Positives = 40/90 (44%), Gaps = 11/90 (12%)
Query: 502 CFNNGVPILEGTSCRCQ--CRLGSLGAACEQTQTEGAKA-DGSWSCWSSWS----VCRAG 554
C +P EGT C CR G C + G + G WS WS WS C G
Sbjct: 553 CETKFMPAAEGTVCGLSMWCRQGQ----CVKFGELGPRPIHGQWSAWSKWSECSRTCGGG 608
Query: 555 IQERRRECDNPAPQNGGASCPGRKVQTQAC 584
++ + R C+NP PQ GG CPG Q C
Sbjct: 609 VKFQERHCNNPKPQYGGLFCPGSSRIYQLC 638
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif,
3 proprotein [Homo sapiens]
Length = 1205
Score = 56.6 bits (135), Expect = 6e-08
Identities = 30/89 (33%), Positives = 39/89 (43%), Gaps = 10/89 (11%)
Query: 502 CFNNGVPILEGTSCRCQ--CRLGSLGAACEQTQTEGAKADGSWSCWSSWS----VCRAGI 555
C P L+GT C C G C K DG+W W+ + C G+
Sbjct: 516 CKTKKGPPLDGTECAAGKWCYKGH----CMWKNANQQKQDGNWGSWTKFGSCSRTCGTGV 571
Query: 556 QERRRECDNPAPQNGGASCPGRKVQTQAC 584
+ R R+C+NP P NGG CPG + Q C
Sbjct: 572 RFRTRQCNNPMPINGGQDCPGVNFEYQLC 600
>gi|62243567 netrin receptor Unc5h1 [Homo sapiens]
Length = 842
Score = 56.6 bits (135), Expect = 6e-08
Identities = 24/47 (51%), Positives = 28/47 (59%), Gaps = 1/47 (2%)
Query: 539 DGSWSCWSSWSVCRAGIQE-RRRECDNPAPQNGGASCPGRKVQTQAC 584
DGSWS WS WS C R REC +PAP+NGG C G + T+ C
Sbjct: 242 DGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNC 288
Score = 30.8 bits (68), Expect = 3.6
Identities = 22/74 (29%), Positives = 32/74 (43%), Gaps = 4/74 (5%)
Query: 29 RRAATPAAVTCQLSNWSEWTDCFPC--QDKKYRHRSLLQP-NKFGGTICSGDIWDQASCS 85
RR+A+ A + +WS W+ C +R R P + GG C G D +C+
Sbjct: 230 RRSASAAVIVYVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCT 289
Query: 86 SSTTCVRQAQCGQD 99
S CV A +D
Sbjct: 290 SD-LCVHTASGPED 302
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif,
9 preproprotein [Homo sapiens]
Length = 1935
Score = 56.2 bits (134), Expect = 8e-08
Identities = 29/89 (32%), Positives = 42/89 (47%), Gaps = 10/89 (11%)
Query: 502 CFNNGVPILEGTSCRC--QCRLGSLGAACEQTQTEGAKADGSWSCWSSWSVCR----AGI 555
C P +GT C C+ G C + + DGSW WS + C GI
Sbjct: 553 CRTQHTPWADGTECEPGKHCKYGF----CVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGI 608
Query: 556 QERRRECDNPAPQNGGASCPGRKVQTQAC 584
+ REC+ P P+NGG C GR+++ ++C
Sbjct: 609 KTAIRECNRPEPKNGGKYCVGRRMKFKSC 637
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1
motif, 16 preproprotein [Homo sapiens]
Length = 1224
Score = 56.2 bits (134), Expect = 8e-08
Identities = 34/90 (37%), Positives = 39/90 (43%), Gaps = 11/90 (12%)
Query: 502 CFNNGVPILEGTSCRCQ--CRLGSLGAACEQTQTEGAK-ADGSWSCWSSWS----VCRAG 554
C +P EGT C CR G C + EG K G WS WSSWS C G
Sbjct: 550 CETKFMPAAEGTICGHDMWCR----GGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGG 605
Query: 555 IQERRRECDNPAPQNGGASCPGRKVQTQAC 584
+ R R C NP P +GG C G + C
Sbjct: 606 VSHRSRLCTNPKPSHGGKFCEGSTRTLKLC 635
Score = 32.3 bits (72), Expect = 1.2
Identities = 22/77 (28%), Positives = 29/77 (37%), Gaps = 8/77 (10%)
Query: 42 SNWSEWTDCFPCQDKKYRHRSLLQPN---KFGGTICSGD-----IWDQASCSSSTTCVRQ 93
S+WS W+ C HRS L N GG C G + + C + R
Sbjct: 590 SDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRA 649
Query: 94 AQCGQDFQCKETGRCLK 110
AQC + + GR K
Sbjct: 650 AQCAEHNSRRFRGRHYK 666
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 56.2 bits (134), Expect = 8e-08
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 5/86 (5%)
Query: 504 NNGVPILEGTSCRC-QCRLGSLGAACEQTQTEGAKADGSWSCWSSWSVCRA----GIQER 558
N+G + SC + R G L +G+W+ WSSW++C G Q R
Sbjct: 628 NSGSCLCRARSCDSPRPRCGGLDCLGPAIHIANCSRNGAWTPWSSWALCSTSCGIGFQVR 687
Query: 559 RRECDNPAPQNGGASCPGRKVQTQAC 584
+R C NPAP++GG C G+ + + C
Sbjct: 688 QRSCSNPAPRHGGRICVGKSREERFC 713
Score = 49.3 bits (116), Expect = 1e-05
Identities = 20/49 (40%), Positives = 25/49 (51%), Gaps = 4/49 (8%)
Query: 540 GSWSCWSSWSVC----RAGIQERRRECDNPAPQNGGASCPGRKVQTQAC 584
G W+ W WS C G + R+R C NP P+NGG C G + Q C
Sbjct: 854 GGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDC 902
Score = 48.1 bits (113), Expect = 2e-05
Identities = 24/54 (44%), Positives = 29/54 (53%), Gaps = 9/54 (16%)
Query: 540 GSWSCWSSWSVCRA----GIQERRRECDNPAPQNGGASCPGRKVQ-----TQAC 584
G+WSCW+SWS C A G +R R C +PAP G C G + TQAC
Sbjct: 911 GAWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCATQAC 964
Score = 39.7 bits (91), Expect = 0.008
Identities = 21/62 (33%), Positives = 27/62 (43%), Gaps = 3/62 (4%)
Query: 524 LGAACEQTQTEGAKADGSWSCWSSWSVCR-AGIQERRRECDNPAPQNGGASCPGRKVQTQ 582
LG E+ WS WS WS C G Q R R C+ P G ++C G Q++
Sbjct: 950 LGLHTEEALCATQACPEGWSPWSEWSKCTDDGAQSRSRHCEELLP--GSSACAGNSSQSR 1007
Query: 583 AC 584
C
Sbjct: 1008 PC 1009
Score = 38.5 bits (88), Expect = 0.017
Identities = 19/47 (40%), Positives = 25/47 (53%), Gaps = 10/47 (21%)
Query: 542 WSCWSSWSVCRA----GIQERRRECDNPAPQNGGASCPGRKVQTQAC 584
W+ W SWS C + G+Q RRR C+N G SC G V+ + C
Sbjct: 725 WASWGSWSKCSSNCGGGMQSRRRACEN------GNSCLGCGVEFKTC 765
Score = 35.8 bits (81), Expect = 0.11
Identities = 17/53 (32%), Positives = 21/53 (39%), Gaps = 7/53 (13%)
Query: 539 DGSWSCWSSWSVCR-------AGIQERRRECDNPAPQNGGASCPGRKVQTQAC 584
DG + WS W C R R CD+P P+ GG C G + C
Sbjct: 609 DGGFGPWSPWQPCEHLDGDNSGSCLCRARSCDSPRPRCGGLDCLGPAIHIANC 661
Score = 31.2 bits (69), Expect = 2.8
Identities = 28/105 (26%), Positives = 38/105 (36%), Gaps = 14/105 (13%)
Query: 44 WSEWTDCFPCQDKKY--RHRSLLQPN-KFGGTICSGDIWDQASCSSSTTC---VRQAQCG 97
WS W C + R RS P + GG IC G ++ C+ +T C + A G
Sbjct: 670 WSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCPVPIFWASWG 729
Query: 98 QDFQCKET--GRCLKRHLVCNGDQDCLDGSDE------DDCEDVR 134
+C G R C CL E + C +VR
Sbjct: 730 SWSKCSSNCGGGMQSRRRACENGNSCLGCGVEFKTCNPEGCPEVR 774
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif,
6 preproprotein [Homo sapiens]
Length = 1117
Score = 56.2 bits (134), Expect = 8e-08
Identities = 30/93 (32%), Positives = 38/93 (40%), Gaps = 14/93 (15%)
Query: 502 CFNNGVPILEGTSCRCQ------CRLGSLGAACEQTQTEGAKADGSWSCWSSWS----VC 551
C N +P EGT C+ C G C T DG W WS W C
Sbjct: 519 CVTNSIPAAEGTLCQTGNIEKGWCYQGD----CVPFGTWPQSIDGGWGPWSLWGECSRTC 574
Query: 552 RAGIQERRRECDNPAPQNGGASCPGRKVQTQAC 584
G+ R CD+PAP GG C G + + ++C
Sbjct: 575 GGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSC 607
>gi|40317626 thrombospondin 1 precursor [Homo sapiens]
Length = 1170
Score = 55.5 bits (132), Expect = 1e-07
Identities = 28/85 (32%), Positives = 40/85 (47%), Gaps = 10/85 (11%)
Query: 504 NNGVPILEGTSCRCQCRLGSLGAACEQTQTEGAKADGSWSCWSSWSVCRA----GIQERR 559
N+ P + G C + R AC++ + +G W WS W +C G+Q+R
Sbjct: 463 NSPSPQMNGKPCEGEARETK---ACKK---DACPINGGWGPWSPWDICSVTCGGGVQKRS 516
Query: 560 RECDNPAPQNGGASCPGRKVQTQAC 584
R C+NP PQ GG C G + Q C
Sbjct: 517 RLCNNPTPQFGGKDCVGDVTENQIC 541
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/101 (36%), Positives = 45/101 (44%), Gaps = 24/101 (23%)
Query: 508 PILEGTSCRCQCRLG---------SLGAACE----QTQT-------EGAKADGSWSCWSS 547
P E TSC C G SL CE QT+T + K DG WS WS
Sbjct: 384 PWSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSP 443
Query: 548 WSVCRA----GIQERRRECDNPAPQNGGASCPGRKVQTQAC 584
WS C G+ R R C++P+PQ G C G +T+AC
Sbjct: 444 WSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKAC 484
Score = 43.5 bits (101), Expect = 5e-04
Identities = 32/100 (32%), Positives = 40/100 (40%), Gaps = 14/100 (14%)
Query: 493 EFNACRCGPCF-NNGVPILEGTSCR---CQCRLGSLGAACEQTQTEGAKADGSWSCWSSW 548
E+ C C N V I + SC C G C + + DG WS WS W
Sbjct: 330 EWTVDSCTECHCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDG-WSPWSEW 388
Query: 549 SVCRA----GIQERRRECDNPAPQNGGASCPGRKVQTQAC 584
+ C GIQ+R R CD+ C G VQT+ C
Sbjct: 389 TSCSTSCGNGIQQRGRSCDSL-----NNRCEGSSVQTRTC 423
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,995,075
Number of Sequences: 37866
Number of extensions: 1142259
Number of successful extensions: 3801
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 109
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 2928
Number of HSP's gapped (non-prelim): 792
length of query: 584
length of database: 18,247,518
effective HSP length: 108
effective length of query: 476
effective length of database: 14,157,990
effective search space: 6739203240
effective search space used: 6739203240
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.